Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_status	validation_method	validation_tumor_sample	validation_alt_allele
TTLL10	254173	broad.mit.edu	37	1	1117566	1117566	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:1117566delG	uc001acy.2	+						uc001acx.1_5'Flank|TTLL10_uc010nyg.1_Intron|TTLL10_uc001acz.1_Intron	NM_001130045	NP_001123517			tubulin tyrosine ligase-like family, member 10						protein modification process		ATP binding|tubulin-tyrosine ligase activity			large_intestine(1)	1	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;4.75e-36)|OV - Ovarian serous cystadenocarcinoma(86;5.82e-22)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)														---	---	---	---
KIAA1751	85452	broad.mit.edu	37	1	1920308	1920308	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:1920308delC	uc001aim.1	-						KIAA1751_uc009vkz.1_Intron|KIAA1751_uc001ain.1_Intron	NM_001080484	NP_001073953			hypothetical protein LOC85452											pancreas(1)	1	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;8.79e-39)|OV - Ovarian serous cystadenocarcinoma(86;9.61e-25)|GBM - Glioblastoma multiforme(42;1.2e-07)|Colorectal(212;4.84e-05)|COAD - Colon adenocarcinoma(227;0.000214)|Kidney(185;0.00254)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)														---	---	---	---
KIAA0562	9731	broad.mit.edu	37	1	3769130	3769130	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:3769130delT	uc001aky.2	-						KIAA0562_uc010nzm.1_Intron|KIAA0562_uc001akz.2_Intron	NM_014704	NP_055519			glycine-, glutamate-,							centriole	binding				0	all_cancers(77;0.0395)|Ovarian(185;0.0634)|all_lung(157;0.222)|Lung NSC(156;0.227)	all_epithelial(116;3.96e-21)|all_lung(118;2.74e-08)|Lung NSC(185;6.4e-06)|Breast(487;0.00066)|Renal(390;0.00121)|Hepatocellular(190;0.00335)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.031)|Lung SC(97;0.0548)|Medulloblastoma(700;0.212)		Epithelial(90;6.85e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.59e-22)|GBM - Glioblastoma multiforme(42;3.16e-16)|Colorectal(212;2.01e-05)|COAD - Colon adenocarcinoma(227;7.99e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000389)|Kidney(185;0.000513)|STAD - Stomach adenocarcinoma(132;0.00709)|KIRC - Kidney renal clear cell carcinoma(229;0.00714)|Lung(427;0.137)														---	---	---	---
RPL22	6146	broad.mit.edu	37	1	6257785	6257785	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:6257785delT	uc001amd.2	-	2	90	c.44delA	c.(43-45)AAGfs	p.K15fs	RPL22_uc001ame.2_Frame_Shift_Del_p.K15fs	NM_000983	NP_000974	P35268	RL22_HUMAN	ribosomal protein L22 proprotein	15					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	heparin binding|RNA binding|structural constituent of ribosome				0	Ovarian(185;0.0634)	all_cancers(23;2.78e-38)|all_epithelial(116;8.88e-22)|all_lung(118;7.95e-08)|Lung NSC(185;1.6e-06)|all_neural(13;3.18e-06)|all_hematologic(16;8.99e-06)|Acute lymphoblastic leukemia(12;0.000365)|Breast(487;0.000496)|Renal(390;0.0007)|Colorectal(325;0.00104)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)|Medulloblastoma(700;0.211)		Epithelial(90;4.53e-38)|GBM - Glioblastoma multiforme(13;3.33e-32)|OV - Ovarian serous cystadenocarcinoma(86;2.8e-19)|Colorectal(212;6.8e-08)|COAD - Colon adenocarcinoma(227;8.04e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00311)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.182)				T	RUNX1	AML|CML								---	---	---	---
TAS1R1	80835	broad.mit.edu	37	1	6634522	6634522	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:6634522delC	uc001ant.2	+						TAS1R1_uc001anu.2_Intron|TAS1R1_uc001anv.2_Intron|TAS1R1_uc001anw.2_Intron	NM_138697	NP_619642			sweet taste receptor T1r isoform b						sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)														---	---	---	---
CAMTA1	23261	broad.mit.edu	37	1	6894337	6894337	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:6894337delT	uc001aoi.2	+						CAMTA1_uc001aoh.2_Intron	NM_015215	NP_056030			calmodulin-binding transcription activator 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)														---	---	---	---
PARK7	11315	broad.mit.edu	37	1	8029588	8029588	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:8029588delA	uc001aou.3	+						PARK7_uc001aow.3_Intron|PARK7_uc001aox.3_Intron|PARK7_uc001aov.3_Intron	NM_001123377	NP_001116849			Parkinson disease protein 7						autophagy|cell death|cellular response to hydrogen peroxide|inflammatory response|mitochondrion organization|negative regulation of cell death|negative regulation of protein binding|neuroprotection|protein stabilization|regulation of androgen receptor signaling pathway|regulation of inflammatory response|single fertilization	mitochondrion|nucleus	mRNA binding|peptidase activity|peroxidase activity|protein homodimerization activity				0	Ovarian(185;0.06)|all_lung(157;0.151)	all_epithelial(116;1.76e-16)|all_lung(118;3.66e-05)|Lung NSC(185;0.000163)|Renal(390;0.000469)|Colorectal(325;0.0033)|Breast(348;0.0044)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;1.28e-70)|GBM - Glioblastoma multiforme(8;3.05e-36)|Colorectal(212;6.83e-08)|COAD - Colon adenocarcinoma(227;7.51e-06)|Kidney(185;5.22e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000414)|KIRC - Kidney renal clear cell carcinoma(229;0.000967)|STAD - Stomach adenocarcinoma(132;0.00102)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
RERE	473	broad.mit.edu	37	1	8420552	8420552	+	Frame_Shift_Del	DEL	G	-	-	rs143760887	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:8420552delG	uc001ape.2	-	19	3825	c.3015delC	c.(3013-3015)CCCfs	p.P1005fs	RERE_uc001apf.2_Frame_Shift_Del_p.P1005fs|RERE_uc010nzx.1_Frame_Shift_Del_p.P737fs|RERE_uc001apd.2_Frame_Shift_Del_p.P451fs	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	1005	Pro-rich.				multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)														---	---	---	---
ENO1	2023	broad.mit.edu	37	1	8926311	8926311	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:8926311delG	uc001apj.1	-						ENO1_uc001api.1_Intron|ENO1_uc001apk.1_Intron|ENO1_uc001apl.1_Intron|ENO1_uc009vmi.1_Intron|ENO1_uc009vmj.1_Intron|ENO1_uc009vmk.1_Intron|ENO1_uc009vml.1_Intron	NM_001428	NP_001419			enolase 1						gluconeogenesis|glycolysis|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|response to virus	phosphopyruvate hydratase complex|plasma membrane|sarcomere	DNA binding|magnesium ion binding|phosphopyruvate hydratase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)|kidney(1)|central_nervous_system(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;2.54e-20)|all_lung(118;2.99e-06)|Lung NSC(185;6.25e-06)|Renal(390;0.000147)|Breast(348;0.00086)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.42e-07)|COAD - Colon adenocarcinoma(227;2.78e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)														---	---	---	---
SLC2A7	155184	broad.mit.edu	37	1	9075048	9075048	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:9075048delC	uc009vmo.1	-							NM_207420	NP_997303			intestinal facilitative glucose transporter 7							integral to membrane|plasma membrane	sugar transmembrane transporter activity				0	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.04e-07)|COAD - Colon adenocarcinoma(227;7.66e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)														---	---	---	---
Unknown	0	broad.mit.edu	37	1	10956094	10956095	+	IGR	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:10956094_10956095insT								CASZ1 (99387 upstream) : C1orf127 (50438 downstream)																																			---	---	---	---
MTOR	2475	broad.mit.edu	37	1	11187619	11187619	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:11187619delT	uc001asd.2	-						MTOR_uc001asc.2_Intron	NM_004958	NP_004949			FK506 binding protein 12-rapamycin associated						cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29																		---	---	---	---
VPS13D	55187	broad.mit.edu	37	1	12463778	12463778	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:12463778delT	uc001atv.2	+						VPS13D_uc001atw.2_Intron|VPS13D_uc001atx.2_Intron|VPS13D_uc009vnl.2_Intron	NM_015378	NP_056193			vacuolar protein sorting 13D isoform 1						protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)														---	---	---	---
NECAP2	55707	broad.mit.edu	37	1	16785155	16785155	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:16785155delA	uc001ayo.2	+						NECAP2_uc001ayp.3_Intron|NECAP2_uc010ocd.1_Intron|NECAP2_uc001ayq.2_Intron	NM_018090	NP_060560			NECAP endocytosis associated 2 isoform 1						endocytosis|protein transport	clathrin vesicle coat|coated pit|plasma membrane					0		Colorectal(325;0.000147)|Renal(390;0.00145)|Lung NSC(340;0.00215)|Breast(348;0.00224)|all_lung(284;0.00351)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(227;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|Kidney(64;0.000181)|KIRC - Kidney renal clear cell carcinoma(64;0.00268)|STAD - Stomach adenocarcinoma(196;0.012)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
MST1P9	11223	broad.mit.edu	37	1	17083584	17083584	+	3'UTR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:17083584delA	uc010ock.1	-	15					CROCC_uc009voy.1_Intron|MST1P9_uc001azp.3_3'UTR	NR_002729				SubName: Full=Hepatocyte growth factor-like protein homolog;												0																		---	---	---	---
UBR4	23352	broad.mit.edu	37	1	19464226	19464226	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:19464226delT	uc001bbi.2	-						UBR4_uc001bbk.1_Intron	NM_020765	NP_065816			retinoblastoma-associated factor 600						interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)														---	---	---	---
UBR4	23352	broad.mit.edu	37	1	19474752	19474753	+	Intron	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:19474752_19474753delAA	uc001bbi.2	-						UBR4_uc001bbk.1_Intron	NM_020765	NP_065816			retinoblastoma-associated factor 600						interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)														---	---	---	---
KIAA0090	23065	broad.mit.edu	37	1	19571589	19571589	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:19571589delA	uc001bbo.2	-						KIAA0090_uc001bbp.2_Intron|KIAA0090_uc001bbq.2_Intron|KIAA0090_uc001bbr.2_Intron	NM_015047	NP_055862			hypothetical protein LOC23065 precursor							integral to membrane	protein binding			ovary(1)	1		Colorectal(325;0.000147)|Renal(390;0.000469)|Breast(348;0.00366)|all_lung(284;0.00519)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00492)|BRCA - Breast invasive adenocarcinoma(304;3.84e-05)|Kidney(64;0.000191)|KIRC - Kidney renal clear cell carcinoma(64;0.00274)|GBM - Glioblastoma multiforme(114;0.005)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0656)														---	---	---	---
MUL1	79594	broad.mit.edu	37	1	20829880	20829880	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:20829880delA	uc001bdi.3	-							NM_024544	NP_078820			mitochondrial ubiquitin ligase activator of NFKB						activation of caspase activity|activation of JUN kinase activity|induction of apoptosis|mitochondrial fission|mitochondrion localization|negative regulation of cell growth|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to mitochondrial outer membrane|nucleus|peroxisome	identical protein binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding				0		Colorectal(325;0.000147)|Renal(390;0.000469)|Lung NSC(340;0.00412)|all_lung(284;0.00419)|Breast(348;0.00748)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000137)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.00124)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)														---	---	---	---
KIF17	57576	broad.mit.edu	37	1	21014538	21014538	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:21014538delT	uc001bdr.3	-						KIF17_uc001bdp.3_5'Flank|KIF17_uc001bdq.3_5'Flank|KIF17_uc009vpx.2_Intron|KIF17_uc001bds.3_Intron	NM_020816	NP_065867			kinesin family member 17 isoform a						microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			ovary(3)|skin(1)	4		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)														---	---	---	---
CELA3B	23436	broad.mit.edu	37	1	22312893	22312893	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:22312893delA	uc001bfk.2	+						CELA3B_uc009vqf.2_Intron	NM_007352	NP_031378			elastase 3B, pancreatic preproprotein						cholesterol metabolic process|proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)	1																		---	---	---	---
ZBTB40	9923	broad.mit.edu	37	1	22835835	22835835	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:22835835delT	uc001bft.2	+						ZBTB40_uc001bfu.2_Intron|ZBTB40_uc009vqi.1_Intron|ZBTB40_uc001bfv.1_Intron	NM_001083621	NP_001077090			zinc finger and BTB domain containing 40						bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)														---	---	---	---
Unknown	0	broad.mit.edu	37	1	23571841	23571841	+	IGR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:23571841delA								HTR1D (50619 upstream) : HNRNPR (64436 downstream)																																			---	---	---	---
C1orf213	148898	broad.mit.edu	37	1	23697711	23697711	+	3'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:23697711delT	uc001bgw.2	+	1					ZNF436_uc001bgt.2_5'Flank|ZNF436_uc001bgu.2_5'Flank|C1orf213_uc001bgv.2_Intron	NM_138479	NP_612488			hypothetical protein LOC148898 isoform 1												0		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;4.97e-26)|Colorectal(126;4.8e-08)|COAD - Colon adenocarcinoma(152;2.83e-06)|GBM - Glioblastoma multiforme(114;5.23e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|KIRC - Kidney renal clear cell carcinoma(1967;0.00314)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0827)|LUSC - Lung squamous cell carcinoma(448;0.184)														---	---	---	---
FUCA1	2517	broad.mit.edu	37	1	24175456	24175457	+	Intron	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:24175456_24175457delTT	uc001bie.2	-							NM_000147	NP_000138			fucosidase, alpha-L-1, tissue precursor						fucose metabolic process|glycosaminoglycan catabolic process	lysosome	alpha-L-fucosidase activity|cation binding			breast(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.00957)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-24)|Colorectal(126;5.69e-08)|COAD - Colon adenocarcinoma(152;3.15e-06)|GBM - Glioblastoma multiforme(114;9.04e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000986)|KIRC - Kidney renal clear cell carcinoma(1967;0.00342)|STAD - Stomach adenocarcinoma(196;0.0128)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.144)														---	---	---	---
SRRM1	10250	broad.mit.edu	37	1	24978984	24978984	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:24978984delA	uc001bjm.2	+	7	1009	c.785delA	c.(784-786)GAAfs	p.E262fs	SRRM1_uc010oel.1_Frame_Shift_Del_p.E262fs|SRRM1_uc009vrh.1_Frame_Shift_Del_p.E223fs|SRRM1_uc009vri.1_Frame_Shift_Del_p.E179fs|SRRM1_uc010oem.1_RNA	NM_005839	NP_005830	Q8IYB3	SRRM1_HUMAN	serine/arginine repetitive matrix 1	262	Pro-rich.|Arg-rich.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nuclear matrix|nuclear speck	DNA binding|protein binding|RNA binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00125)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0422)|OV - Ovarian serous cystadenocarcinoma(117;1.01e-24)|Colorectal(126;5.95e-08)|COAD - Colon adenocarcinoma(152;3.24e-06)|GBM - Glioblastoma multiforme(114;0.000148)|BRCA - Breast invasive adenocarcinoma(304;0.00177)|KIRC - Kidney renal clear cell carcinoma(1967;0.00348)|STAD - Stomach adenocarcinoma(196;0.00483)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.138)														---	---	---	---
SYF2	25949	broad.mit.edu	37	1	25554441	25554441	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:25554441delT	uc001bjt.1	-						SYF2_uc001bju.1_Intron|SYF2_uc010oeo.1_Intron	NM_015484	NP_056299			SYF2 homolog, RNA splicing factor isoform 1							catalytic step 2 spliceosome					0		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.5e-26)|Colorectal(126;2.54e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000455)|STAD - Stomach adenocarcinoma(196;0.000766)|KIRC - Kidney renal clear cell carcinoma(1967;0.00145)|GBM - Glioblastoma multiforme(114;0.00443)|READ - Rectum adenocarcinoma(331;0.0936)|Lung(427;0.201)														---	---	---	---
LOC653566	653566	broad.mit.edu	37	1	28422755	28422756	+	Frame_Shift_Del	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:28422755_28422756delAA	uc010ofv.1	-	1	314_315	c.178_179delTT	c.(178-180)TTGfs	p.L60fs		NM_014752	NP_055567			signal peptidase complex subunit 2 homolog												0																		---	---	---	---
YTHDF2	51441	broad.mit.edu	37	1	29095640	29095640	+	3'UTR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:29095640delA	uc001brc.2	+	5					YTHDF2_uc001brd.2_3'UTR|YTHDF2_uc010ofx.1_3'UTR|YTHDF2_uc001bre.2_3'UTR	NM_016258	NP_057342			high glucose-regulated protein 8						humoral immune response					ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;0.000601)|all_lung(284;0.000771)|Breast(348;0.00502)|Renal(390;0.00758)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;5.46e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
SFRS4	6429	broad.mit.edu	37	1	29481429	29481429	+	Intron	DEL	A	-	-	rs66504457		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:29481429delA	uc001bro.2	-						SFRS4_uc010ofy.1_Intron|SFRS4_uc009vtp.2_Intron	NM_005626	NP_005617			splicing factor, arginine/serine-rich 4						mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|RNA binding				0		Colorectal(325;0.00161)|Breast(348;0.0364)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0529)|Lung NSC(340;0.0654)|all_lung(284;0.074)|Ovarian(437;0.104)|Medulloblastoma(700;0.151)		Colorectal(126;1.01e-07)|COAD - Colon adenocarcinoma(152;6.21e-06)|STAD - Stomach adenocarcinoma(196;0.0196)|BRCA - Breast invasive adenocarcinoma(304;0.0531)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.138)														---	---	---	---
DCDC2B	149069	broad.mit.edu	37	1	32680712	32680714	+	Intron	DEL	AAA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:32680712_32680714delAAA	uc001bun.2	+						C1orf91_uc001buo.3_Intron|C1orf91_uc001bup.3_Intron	NM_001099434	NP_001092904			doublecortin domain containing 2B						intracellular signal transduction						0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)																---	---	---	---
LCK	3932	broad.mit.edu	37	1	32745227	32745227	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:32745227delC	uc001bux.2	+						LCK_uc001buy.2_Intron|LCK_uc001buz.2_Frame_Shift_Del_p.S337fs|LCK_uc010ohc.1_Intron|LCK_uc001bva.2_Intron	NM_005356	NP_005347			lymphocyte-specific protein tyrosine kinase						activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			lung(3)|central_nervous_system(2)|ovary(1)	6		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)			T	TRB@	T-ALL								---	---	---	---
ZMYM6	9204	broad.mit.edu	37	1	35485090	35485090	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:35485090delT	uc001byh.2	-	4	520	c.292delA	c.(292-294)ATGfs	p.M98fs	ZMYM6_uc001byf.1_Frame_Shift_Del_p.M98fs|ZMYM6_uc010oht.1_Frame_Shift_Del_p.M1fs|ZMYM6_uc009vup.2_Intron|ZMYM6_uc009vuq.1_Frame_Shift_Del_p.M98fs|ZMYM6_uc009vur.1_Intron|ZMYM6_uc001byj.2_Frame_Shift_Del_p.M98fs|ZMYM6_uc001byi.2_Frame_Shift_Del_p.M98fs|ZMYM6_uc001byk.2_Frame_Shift_Del_p.M98fs	NM_007167	NP_009098	O95789	ZMYM6_HUMAN	zinc finger protein 258	98					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)																---	---	---	---
ZMYM6	9204	broad.mit.edu	37	1	35485262	35485263	+	Intron	DEL	TC	-	-	rs11577748		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:35485262_35485263delTC	uc001byh.2	-						ZMYM6_uc001byf.1_Intron|ZMYM6_uc010oht.1_Intron|ZMYM6_uc009vup.2_Intron|ZMYM6_uc009vuq.1_Intron|ZMYM6_uc009vur.1_Intron|ZMYM6_uc001byj.2_Intron|ZMYM6_uc001byi.2_Intron|ZMYM6_uc001byk.2_Intron	NM_007167	NP_009098			zinc finger protein 258						multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)																---	---	---	---
CLSPN	63967	broad.mit.edu	37	1	36203711	36203724	+	Intron	DEL	AAAAATATATATAT	-	-	rs59268543	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:36203711_36203724delAAAAATATATATAT	uc001bzi.2	-						CLSPN_uc009vux.2_Intron	NM_022111	NP_071394			claspin						activation of protein kinase activity|cell cycle|cellular component disassembly involved in apoptosis|DNA repair|DNA replication|G2/M transition DNA damage checkpoint|mitotic cell cycle DNA replication checkpoint|peptidyl-serine phosphorylation	nucleoplasm	anaphase-promoting complex binding|DNA binding			breast(2)|ovary(2)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)	8		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)																---	---	---	---
CDCA8	55143	broad.mit.edu	37	1	38170966	38170966	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:38170966delT	uc001cbr.2	+						CDCA8_uc001cbs.2_Intron|CDCA8_uc010oih.1_Intron	NM_018101	NP_060571			cell division cycle associated 8						cell division|chromosome organization|mitotic metaphase|mitotic prometaphase	chromosome passenger complex|chromosome, centromeric region|cytosol|nucleolus|spindle	protein binding			central_nervous_system(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)																---	---	---	---
AKIRIN1	79647	broad.mit.edu	37	1	39466956	39466963	+	Intron	DEL	TTTTTTTT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:39466956_39466963delTTTTTTTT	uc001ccw.2	+						AKIRIN1_uc010oip.1_Intron|AKIRIN1_uc010oiq.1_Intron	NM_024595	NP_078871			akirin 1 isoform 1							nucleus					0																		---	---	---	---
MACF1	23499	broad.mit.edu	37	1	39889627	39889628	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:39889627_39889628insT	uc010oiu.1	+						MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron	NM_033044	NP_149033			microfilament and actin filament cross-linker						cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)															---	---	---	---
PABPC4	8761	broad.mit.edu	37	1	40038263	40038264	+	Intron	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:40038263_40038264delAA	uc010oiv.1	-						PABPC4_uc001cdl.2_Intron|PABPC4_uc001cdm.2_Intron	NM_003819	NP_003810			poly A binding protein, cytoplasmic 4 isoform 2						blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding				0	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)															---	---	---	---
HPCAL4	51440	broad.mit.edu	37	1	40148562	40148562	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:40148562delT	uc001cdr.2	-						HPCAL4_uc010oix.1_Intron	NM_016257	NP_057341			hippocalcin-like protein 4						central nervous system development	intracellular	calcium ion binding			central_nervous_system(1)	1	all_cancers(7;4.65e-13)|Lung NSC(20;2.88e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)															---	---	---	---
BMP8B	656	broad.mit.edu	37	1	40229212	40229212	+	Intron	DEL	A	-	-	rs113575841		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:40229212delA	uc001cdz.1	-						PPIE_uc001cdv.2_Intron|PPIE_uc001cdw.2_Intron	NM_001720	NP_001711			bone morphogenetic protein 8B preproprotein						cartilage development|cell differentiation|growth|ossification	extracellular space	cytokine activity|growth factor activity				0	all_cancers(7;5.56e-14)|all_lung(5;3.88e-17)|all_epithelial(6;3.78e-16)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;1.92e-17)|all cancers(16;4.03e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)															---	---	---	---
COL9A2	1298	broad.mit.edu	37	1	40775459	40775460	+	Intron	DEL	AC	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:40775459_40775460delAC	uc001cfh.1	-						COL9A2_uc001cfi.1_Intron	NM_001852	NP_001843			alpha 2 type IX collagen precursor						axon guidance|skeletal system development	collagen type IX				ovary(2)	2	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.08e-17)															---	---	---	---
CCDC30	728621	broad.mit.edu	37	1	43021760	43021760	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:43021760delT	uc009vwk.1	+						CCDC30_uc001chm.2_Intron|CCDC30_uc001chn.2_Intron|CCDC30_uc010oju.1_Intron|CCDC30_uc001chp.2_Intron	NM_001080850	NP_001074319			coiled-coil domain containing 30												0																		---	---	---	---
ST3GAL3	6487	broad.mit.edu	37	1	44280549	44280550	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:44280549_44280550insT	uc001ckc.2	+						ST3GAL3_uc009vwu.1_Intron|ST3GAL3_uc010okj.1_Intron|ST3GAL3_uc001cjz.2_Intron|ST3GAL3_uc001cka.2_Intron|ST3GAL3_uc001ckb.2_Intron|ST3GAL3_uc001ckd.2_Intron|ST3GAL3_uc001cke.2_Intron|ST3GAL3_uc001ckf.2_Intron|ST3GAL3_uc001ckg.2_Intron|ST3GAL3_uc001ckh.2_Intron|ST3GAL3_uc001cki.2_Intron|ST3GAL3_uc009vwv.2_Intron|ST3GAL3_uc001ckj.2_Intron|ST3GAL3_uc009vww.2_Intron|ST3GAL3_uc001ckk.2_Intron|ST3GAL3_uc009vwy.2_Intron|ST3GAL3_uc009vwx.2_Intron|ST3GAL3_uc001ckm.2_Intron|ST3GAL3_uc001ckl.2_Intron|ST3GAL3_uc009vwz.2_Intron|ST3GAL3_uc001ckn.2_Intron|ST3GAL3_uc001ckp.2_Intron|ST3GAL3_uc001cko.2_Intron|ST3GAL3_uc009vxa.2_Intron|ST3GAL3_uc001ckq.2_Intron|ST3GAL3_uc001ckr.2_Intron|ST3GAL3_uc009vxb.2_Intron	NM_006279	NP_006270			sialyltransferase 6 isoform j						protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	N-acetyllactosaminide alpha-2,3-sialyltransferase activity			ovary(3)	3	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0518)																---	---	---	---
PLK3	1263	broad.mit.edu	37	1	45268997	45268997	+	Frame_Shift_Del	DEL	C	-	-	rs112574988		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:45268997delC	uc001cmn.2	+	8	1106	c.1006delC	c.(1006-1008)CCCfs	p.P336fs	PLK3_uc001cmo.2_RNA	NM_004073	NP_004064	Q9H4B4	PLK3_HUMAN	polo-like kinase 3	336						membrane	ATP binding|protein binding|protein serine/threonine kinase activity				0	Acute lymphoblastic leukemia(166;0.155)																	---	---	---	---
MUTYH	4595	broad.mit.edu	37	1	45798756	45798756	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:45798756delC	uc001cnm.2	-						MUTYH_uc009vxn.2_Intron|MUTYH_uc001cnf.2_Intron|MUTYH_uc009vxo.2_Intron|MUTYH_uc001cng.2_Intron|MUTYH_uc001cnj.2_Intron|MUTYH_uc001cni.2_Intron|MUTYH_uc001cnh.2_Intron|MUTYH_uc001cno.2_Intron|MUTYH_uc001cnk.2_Intron|MUTYH_uc010oll.1_Intron|MUTYH_uc001cnl.2_Intron|MUTYH_uc009vxp.2_Intron|MUTYH_uc001cnn.2_Intron	NM_012222	NP_036354			mutY homolog isoform 1						depurination|mismatch repair	nucleoplasm	4 iron, 4 sulfur cluster binding|DNA N-glycosylase activity|endonuclease activity|metal ion binding|MutSalpha complex binding				0	Acute lymphoblastic leukemia(166;0.155)							Mis			colorectal		BER_DNA_glycosylases	MUTYH-associated_polyposis				---	---	---	---
TESK2	10420	broad.mit.edu	37	1	45851464	45851464	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:45851464delT	uc001cns.1	-						TESK2_uc009vxr.1_Intron|TESK2_uc010olo.1_Intron|TESK2_uc009vxs.1_Intron	NM_007170	NP_009101			testis-specific protein kinase 2						actin cytoskeleton organization|focal adhesion assembly|spermatogenesis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(2)|breast(2)|pancreas(1)	5	Acute lymphoblastic leukemia(166;0.155)																	---	---	---	---
GPBP1L1	60313	broad.mit.edu	37	1	46095127	46095130	+	Intron	DEL	CCCC	-	-	rs74074404		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:46095127_46095130delCCCC	uc001coq.2	-						GPBP1L1_uc001coo.2_Intron	NM_021639	NP_067652			GC-rich promoter binding protein 1-like 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)																	---	---	---	---
GPBP1L1	60313	broad.mit.edu	37	1	46096014	46096014	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:46096014delG	uc001coq.2	-						GPBP1L1_uc001coo.2_Intron	NM_021639	NP_067652			GC-rich promoter binding protein 1-like 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)																	---	---	---	---
IPP	3652	broad.mit.edu	37	1	46179806	46179806	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:46179806delA	uc001cou.2	-						IPP_uc001cos.3_Intron	NM_005897	NP_005888			intracisternal A particle-promoted polypeptide							actin cytoskeleton|cytoplasm	actin binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)																	---	---	---	---
PIK3R3	8503	broad.mit.edu	37	1	46511446	46511446	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:46511446delT	uc001cpb.3	-						PIK3R3_uc009vyb.2_Intron|PIK3R3_uc009vyc.2_Intron|PIK3R3_uc001cpc.3_Intron|PIK3R3_uc010olw.1_Intron|PIK3R3_uc010olv.1_Intron	NM_003629	NP_003620			phosphoinositide-3-kinase, regulatory subunit 3						insulin receptor signaling pathway|platelet activation|T cell costimulation		1-phosphatidylinositol-3-kinase activity|protein binding				0	Acute lymphoblastic leukemia(166;0.155)																	---	---	---	---
PIK3R3	8503	broad.mit.edu	37	1	46546081	46546081	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:46546081delT	uc001cpb.3	-						PIK3R3_uc009vyb.2_Intron|PIK3R3_uc009vyc.2_Intron|PIK3R3_uc001cpc.3_Intron|PIK3R3_uc010olw.1_Intron	NM_003629	NP_003620			phosphoinositide-3-kinase, regulatory subunit 3						insulin receptor signaling pathway|platelet activation|T cell costimulation		1-phosphatidylinositol-3-kinase activity|protein binding				0	Acute lymphoblastic leukemia(166;0.155)																	---	---	---	---
Unknown	0	broad.mit.edu	37	1	46782478	46782479	+	IGR	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:46782478_46782479delTT								UQCRH (33 upstream) : NSUN4 (23911 downstream)																																			---	---	---	---
CYP4X1	260293	broad.mit.edu	37	1	47489621	47489621	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:47489621delC	uc001cqt.2	+	1	382	c.132delC	c.(130-132)CGCfs	p.R44fs	CYP4X1_uc001cqr.2_Intron|CYP4X1_uc001cqs.2_Intron	NM_178033	NP_828847	Q8N118	CP4X1_HUMAN	cytochrome P450, family 4, subfamily X,	44						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)|skin(1)	2																		---	---	---	---
SPATA6	54558	broad.mit.edu	37	1	48764290	48764291	+	3'UTR	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:48764290_48764291insT	uc001crr.1	-	13					SPATA6_uc001crs.1_3'UTR|SPATA6_uc010omv.1_3'UTR	NM_019073	NP_061946			spermatogenesis associated 6 precursor						cell differentiation|multicellular organismal development|spermatogenesis	extracellular region				ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	1	50865017	50865018	+	IGR	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:50865017_50865018delTT								ELAVL4 (197477 upstream) : DMRTA2 (18211 downstream)																																			---	---	---	---
FAF1	11124	broad.mit.edu	37	1	51180667	51180667	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:51180667delA	uc009vyx.1	-						FAF1_uc009vyw.1_Intron|FAF1_uc001cse.1_Intron	NM_007051	NP_008982			FAS-associated factor 1						apoptosis|cytoplasmic sequestering of NF-kappaB|positive regulation of apoptosis|positive regulation of protein complex assembly|proteasomal ubiquitin-dependent protein catabolic process|regulation of protein catabolic process	CD95 death-inducing signaling complex|cytosol|perinuclear region of cytoplasm	heat shock protein binding|NF-kappaB binding|protein kinase binding|protein kinase regulator activity	p.0?(1)		ovary(1)|pancreas(1)	2				GBM - Glioblastoma multiforme(3;3.18e-11)|all cancers(3;0.00526)														---	---	---	---
TXNDC12	51060	broad.mit.edu	37	1	52520880	52520880	+	5'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:52520880delT	uc001cti.2	-	1					BTF3L4_uc001ctk.2_5'Flank|BTF3L4_uc001ctl.2_5'Flank|BTF3L4_uc010onh.1_5'Flank	NM_015913	NP_056997			thioredoxin domain containing 12 precursor						activation of caspase activity|apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytosol|mitochondrial inner membrane|mitochondrial intermembrane space|nucleus|perinuclear region of cytoplasm	DNA binding|electron carrier activity|flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			ovary(1)	1																		---	---	---	---
ZCCHC11	23318	broad.mit.edu	37	1	52923972	52923972	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:52923972delA	uc001ctx.2	-						ZCCHC11_uc001cty.2_Intron|ZCCHC11_uc001ctz.2_Intron|ZCCHC11_uc009vze.1_Intron|ZCCHC11_uc009vzf.1_Intron|ZCCHC11_uc001cua.1_Intron	NM_015269	NP_056084			zinc finger, CCHC domain containing 11 isoform						miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)|skin(1)	3																		---	---	---	---
ZCCHC11	23318	broad.mit.edu	37	1	52956483	52956483	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:52956483delA	uc001ctx.2	-						ZCCHC11_uc001cty.2_Intron|ZCCHC11_uc001ctz.2_Intron|ZCCHC11_uc009vze.1_Intron|ZCCHC11_uc009vzf.1_Intron|ZCCHC11_uc001cub.2_Intron|ZCCHC11_uc001cuc.2_Intron	NM_015269	NP_056084			zinc finger, CCHC domain containing 11 isoform						miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)|skin(1)	3																		---	---	---	---
ZCCHC11	23318	broad.mit.edu	37	1	52959246	52959246	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:52959246delA	uc001ctx.2	-						ZCCHC11_uc001cty.2_Intron|ZCCHC11_uc001ctz.2_Intron|ZCCHC11_uc009vze.1_Intron|ZCCHC11_uc009vzf.1_Intron|ZCCHC11_uc001cub.2_Intron|ZCCHC11_uc001cuc.2_Intron	NM_015269	NP_056084			zinc finger, CCHC domain containing 11 isoform						miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)|skin(1)	3																		---	---	---	---
ZYG11B	79699	broad.mit.edu	37	1	53238351	53238352	+	Intron	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:53238351_53238352delTT	uc001cuj.2	+						ZYG11B_uc009vzg.2_Intron|ZYG11B_uc010onj.1_Intron	NM_024646	NP_078922			zyg-11 homolog B								protein binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4																		---	---	---	---
LRP8	7804	broad.mit.edu	37	1	53722847	53722847	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:53722847delC	uc001cvi.1	-						LRP8_uc001cvh.1_Intron|LRP8_uc001cvk.1_Intron|LRP8_uc001cvj.1_Intron|LRP8_uc001cvl.1_Intron|LRP8_uc001cvm.1_Intron	NM_004631	NP_004622			low density lipoprotein receptor-related protein						cytokine-mediated signaling pathway|endocytosis|lipid metabolic process|platelet activation|proteolysis	caveola	calcium ion binding|very-low-density lipoprotein particle receptor activity				0																		---	---	---	---
ACOT11	26027	broad.mit.edu	37	1	55082006	55082007	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:55082006_55082007insT	uc001cxm.1	+						FAM151A_uc001cxn.2_Intron	NM_015547	NP_056362			thioesterase, adipose associated isoform BFIT1						fatty acid metabolic process|intracellular signal transduction|response to cold		acyl-CoA thioesterase activity|carboxylesterase activity			central_nervous_system(1)	1																		---	---	---	---
PRKAA2	5563	broad.mit.edu	37	1	57158313	57158313	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:57158313delT	uc001cyk.3	+							NM_006252	NP_006243			AMP-activated protein kinase alpha 2 catalytic						carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(4)|ovary(1)|stomach(1)	6																		---	---	---	---
MYSM1	114803	broad.mit.edu	37	1	59137432	59137432	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:59137432delT	uc009wab.1	-						MYSM1_uc009waa.1_5'Flank|MYSM1_uc001czc.2_Intron	NM_001085487	NP_001078956			Myb-like, SWIRM and MPN domains 1						histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin remodeling complex	DNA binding|histone binding|metal ion binding|metallopeptidase activity|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(1)	1	all_cancers(7;9.36e-06)																	---	---	---	---
FGGY	55277	broad.mit.edu	37	1	59977913	59977913	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:59977913delA	uc001czi.3	+						FGGY_uc001czg.2_Intron|FGGY_uc001czh.2_Intron|FGGY_uc009wac.2_Intron|FGGY_uc001czj.3_Intron|FGGY_uc001czk.3_Intron|FGGY_uc001czl.3_Intron	NM_018291	NP_060761			FGGY carbohydrate kinase domain containing						carbohydrate metabolic process|cell death|neuron homeostasis		kinase activity|phosphotransferase activity, alcohol group as acceptor			ovary(1)	1	all_cancers(7;7.36e-05)																	---	---	---	---
INADL	10207	broad.mit.edu	37	1	62271345	62271345	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:62271345delT	uc001dab.2	+						INADL_uc009waf.1_Intron|INADL_uc001daa.2_Intron|INADL_uc001dad.3_Intron|INADL_uc001dac.2_Intron	NM_176877	NP_795352			InaD-like						intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4																		---	---	---	---
INADL	10207	broad.mit.edu	37	1	62613787	62613788	+	Intron	DEL	TG	-	-	rs66743140		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:62613787_62613788delTG	uc001dab.2	+						INADL_uc001dac.2_Intron|INADL_uc009wag.2_Intron	NM_176877	NP_795352			InaD-like						intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4																		---	---	---	---
DOCK7	85440	broad.mit.edu	37	1	63069564	63069564	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:63069564delA	uc001daq.2	-						DOCK7_uc001dan.2_Intron|DOCK7_uc001dao.2_Intron|DOCK7_uc001dap.2_Intron|DOCK7_uc009wah.1_Intron|ANGPTL3_uc001das.1_Intron	NM_033407	NP_212132			dedicator of cytokinesis 7						activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2																		---	---	---	---
DOCK7	85440	broad.mit.edu	37	1	63084720	63084720	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:63084720delA	uc001daq.2	-						DOCK7_uc001dan.2_Intron|DOCK7_uc001dao.2_Intron|DOCK7_uc001dap.2_Intron|DOCK7_uc009wah.1_Intron	NM_033407	NP_212132			dedicator of cytokinesis 7						activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2																		---	---	---	---
ALG6	29929	broad.mit.edu	37	1	63885020	63885021	+	Intron	INS	-	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:63885020_63885021insC	uc010oow.1	+						ALG6_uc001daz.2_Intron|ALG6_uc009waj.2_Intron|ALG6_uc010oox.1_Intron	NM_013339	NP_037471			dolichyl pyrophosphate Man9GlcNAc2						dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity				0																		---	---	---	---
ROR1	4919	broad.mit.edu	37	1	64603302	64603302	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:64603302delA	uc001dbj.2	+						ROR1_uc001dbi.3_Intron|uc001dbl.2_Intron	NM_005012	NP_005003			receptor tyrosine kinase-like orphan receptor 1						transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			ovary(6)|large_intestine(3)|breast(3)|stomach(2)|lung(2)|central_nervous_system(1)|skin(1)|kidney(1)	19																		---	---	---	---
LEPR	3953	broad.mit.edu	37	1	66042478	66042478	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:66042478delT	uc001dci.2	+						LEPR_uc001dcg.2_Intron|LEPR_uc001dch.2_Intron|LEPR_uc009waq.2_Intron|LEPR_uc001dcj.2_Intron|LEPR_uc001dck.2_Intron	NM_002303	NP_002294			leptin receptor isoform 1						energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)														---	---	---	---
LEPR	3953	broad.mit.edu	37	1	66062116	66062116	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:66062116delT	uc001dci.2	+						LEPR_uc001dcg.2_Intron|LEPR_uc001dch.2_Intron|LEPR_uc009waq.2_Intron|LEPR_uc001dcj.2_Intron|LEPR_uc001dck.2_Intron	NM_002303	NP_002294			leptin receptor isoform 1						energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)														---	---	---	---
ZRANB2	9406	broad.mit.edu	37	1	71542334	71542334	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:71542334delA	uc001dft.2	-						ZRANB2_uc001dfs.2_Intron	NM_203350	NP_976225			zinc finger protein 265 isoform 1						mRNA processing|RNA splicing	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2																		---	---	---	---
ZRANB2	9406	broad.mit.edu	37	1	71542440	71542440	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:71542440delA	uc001dft.2	-						ZRANB2_uc001dfs.2_Intron	NM_203350	NP_976225			zinc finger protein 265 isoform 1						mRNA processing|RNA splicing	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2																		---	---	---	---
LHX8	431707	broad.mit.edu	37	1	75606525	75606525	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:75606525delA	uc001dgo.2	+						LHX8_uc001dgq.2_Intron	NM_001001933	NP_001001933			LIM homeobox 8							nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3																		---	---	---	---
RABGGTB	5876	broad.mit.edu	37	1	76253300	76253300	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:76253300delT	uc001dgy.1	+						RABGGTB_uc009wbt.1_Intron|RABGGTB_uc001dha.1_Intron|SNORD45A_uc009wbu.1_5'Flank|SNORD45B_uc009wbv.1_5'Flank	NM_004582	NP_004573			RAB geranylgeranyltransferase, beta subunit						protein modification process|visual perception		metal ion binding|protein binding|Rab geranylgeranyltransferase activity			ovary(1)	1																		---	---	---	---
MSH4	4438	broad.mit.edu	37	1	76269318	76269318	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:76269318delA	uc001dhd.1	+							NM_002440	NP_002431			mutS homolog 4						chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			lung(3)|ovary(2)	5													MMR					---	---	---	---
AK5	26289	broad.mit.edu	37	1	77952225	77952225	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:77952225delA	uc001dhn.2	+						AK5_uc001dho.2_Intron	NM_174858	NP_777283			adenylate kinase 5 isoform 1						ADP biosynthetic process|ATP metabolic process|dADP biosynthetic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine ribonucleotide biosynthetic process|signal transduction	centrosome|cytosol	adenylate kinase activity|ATP binding|cAMP-dependent protein kinase regulator activity|nucleoside kinase activity			skin(1)	1																		---	---	---	---
USP33	23032	broad.mit.edu	37	1	78178976	78178976	+	Intron	DEL	T	-	-	rs6603958	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:78178976delT	uc001dht.2	-						USP33_uc001dhs.2_Intron|USP33_uc001dhu.2_Intron|USP33_uc001dhv.2_Intron|USP33_uc001dhw.2_Intron	NM_015017	NP_055832			ubiquitin specific protease 33 isoform 1						axon guidance|cell migration|endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|VCB complex	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(2)|ovary(1)	3																		---	---	---	---
USP33	23032	broad.mit.edu	37	1	78188044	78188044	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:78188044delA	uc001dht.2	-						USP33_uc001dhs.2_Intron|USP33_uc001dhu.2_Intron|USP33_uc001dhv.2_Intron|USP33_uc001dhw.2_Intron	NM_015017	NP_055832			ubiquitin specific protease 33 isoform 1						axon guidance|cell migration|endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|VCB complex	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(2)|ovary(1)	3																		---	---	---	---
USP33	23032	broad.mit.edu	37	1	78204691	78204692	+	Intron	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:78204691_78204692delAA	uc001dht.2	-						USP33_uc001dhu.2_Intron|USP33_uc001dhv.2_Intron|USP33_uc001dhw.2_Intron	NM_015017	NP_055832			ubiquitin specific protease 33 isoform 1						axon guidance|cell migration|endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|VCB complex	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(2)|ovary(1)	3																		---	---	---	---
FAM73A	374986	broad.mit.edu	37	1	78325075	78325075	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:78325075delT	uc001dhx.2	+						FAM73A_uc010ork.1_Intron|FAM73A_uc010orl.1_Intron|FAM73A_uc001dhy.1_3'UTR	NM_198549	NP_940951			hypothetical protein LOC374986							integral to membrane				ovary(1)	1				Colorectal(170;0.226)														---	---	---	---
NEXN	91624	broad.mit.edu	37	1	78383789	78383789	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:78383789delT	uc001dic.3	+						NEXN_uc001dia.3_Intron|NEXN_uc009wcb.1_Intron|NEXN_uc001dib.3_Intron|NEXN_uc001did.1_Intron|NEXN_uc001dif.1_5'Flank	NM_144573	NP_653174			nexilin (F actin binding protein)						regulation of cell migration|regulation of cytoskeleton organization	cytoskeleton|Z disc	actin filament binding|structural constituent of muscle			ovary(2)	2				Colorectal(170;0.114)														---	---	---	---
PTGFR	5737	broad.mit.edu	37	1	78958519	78958519	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:78958519delT	uc001din.2	+	2	357	c.91delT	c.(91-93)TTTfs	p.F31fs	PTGFR_uc001dim.2_Frame_Shift_Del_p.F31fs	NM_000959	NP_000950	P43088	PF2R_HUMAN	prostaglandin F receptor isoform a precursor	31	Extracellular (Potential).				parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			ovary(3)|breast(2)|skin(1)	6				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)													---	---	---	---
Unknown	0	broad.mit.edu	37	1	79132207	79132207	+	IGR	DEL	A	-	-	rs149208484		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:79132207delA								IFI44 (2446 upstream) : ELTD1 (223244 downstream)																																			---	---	---	---
ELTD1	64123	broad.mit.edu	37	1	79387244	79387245	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:79387244_79387245insA	uc001diq.3	-							NM_022159	NP_071442			EGF, latrophilin and seven transmembrane domain						neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)														---	---	---	---
LPHN2	23266	broad.mit.edu	37	1	82187977	82187977	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:82187977delA	uc001dit.3	+						LPHN2_uc001dis.2_Intron	NM_012302	NP_036434			latrophilin 2 precursor						neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)														---	---	---	---
LPHN2	23266	broad.mit.edu	37	1	82302485	82302486	+	Intron	DEL	GA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:82302485_82302486delGA	uc001dit.3	+						LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Intron|LPHN2_uc001div.2_Intron|LPHN2_uc009wcd.2_Intron	NM_012302	NP_036434			latrophilin 2 precursor						neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)														---	---	---	---
SSX2IP	117178	broad.mit.edu	37	1	85115559	85115559	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:85115559delT	uc001dkh.2	-						SSX2IP_uc001dkf.2_Intron|SSX2IP_uc001dkg.2_RNA|SSX2IP_uc010orz.1_Intron|SSX2IP_uc001dki.2_Intron|SSX2IP_uc010osa.1_Intron|SSX2IP_uc001dkj.2_Intron|SSX2IP_uc009wci.2_3'UTR	NM_014021	NP_054740			synovial sarcoma, X breakpoint 2 interacting						cell adhesion	nucleus|protein complex				ovary(2)	2				all cancers(265;0.0053)|Epithelial(280;0.0214)|OV - Ovarian serous cystadenocarcinoma(397;0.173)														---	---	---	---
SH3GLB1	51100	broad.mit.edu	37	1	87185124	87185124	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:87185124delA	uc001dlw.2	+						SH3GLB1_uc001dlx.2_Intron|SH3GLB1_uc001dly.2_Intron|SH3GLB1_uc001dlz.2_Intron	NM_016009	NP_057093			SH3-containing protein SH3GLB1						anti-apoptosis|filopodium assembly|signal transduction	Golgi membrane|mitochondrial outer membrane	cytoskeletal adaptor activity|protein homodimerization activity|SH3 domain binding				0		Lung NSC(277;0.209)		all cancers(265;0.0136)|Epithelial(280;0.0414)														---	---	---	---
ZNF644	84146	broad.mit.edu	37	1	91382293	91382293	+	3'UTR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:91382293delA	uc001dnw.2	-	6					ZNF644_uc001dnv.2_3'UTR|ZNF644_uc001dnx.2_3'UTR	NM_201269	NP_958357			zinc finger protein 644 isoform 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)														---	---	---	---
HFM1	164045	broad.mit.edu	37	1	91790375	91790376	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:91790375_91790376insT	uc001doa.3	-						HFM1_uc009wdb.2_Intron|HFM1_uc010osu.1_Intron|HFM1_uc001dob.3_Intron|HFM1_uc010osv.1_Intron	NM_001017975	NP_001017975			HFM1 protein								ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)														---	---	---	---
HFM1	164045	broad.mit.edu	37	1	91851004	91851005	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:91851004_91851005insA	uc001doa.3	-						HFM1_uc010osu.1_Intron|HFM1_uc010osv.1_Intron|HFM1_uc001doc.1_Intron	NM_001017975	NP_001017975			HFM1 protein								ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)														---	---	---	---
BRDT	676	broad.mit.edu	37	1	92428533	92428533	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:92428533delA	uc001dok.3	+						BRDT_uc001dol.3_Intron|BRDT_uc010osz.1_Intron|BRDT_uc009wdf.2_Intron|BRDT_uc010ota.1_Intron|BRDT_uc010otb.1_Intron|BRDT_uc001dom.3_Intron	NM_207189	NP_997072			testis-specific bromodomain protein						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			stomach(2)|ovary(1)|lung(1)	4		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)														---	---	---	---
GLMN	11146	broad.mit.edu	37	1	92735195	92735199	+	Intron	DEL	AAAGA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:92735195_92735199delAAAGA	uc001dor.2	-						GLMN_uc009wdg.2_Intron|GLMN_uc001dos.2_Intron	NM_053274	NP_444504			glomulin						muscle cell differentiation|negative regulation of T cell proliferation|positive regulation of cytokine secretion|positive regulation of interleukin-2 biosynthetic process|positive regulation of phosphorylation|regulation of gene expression, epigenetic|vasculogenesis	intracellular	hepatocyte growth factor receptor binding			skin(1)	1		all_lung(203;0.00827)|Lung NSC(277;0.0295)		all cancers(265;0.00702)|GBM - Glioblastoma multiforme(16;0.0381)|Epithelial(280;0.0989)										Multiple_Glomus_Tumors_(of_the_Skin)_Familial				---	---	---	---
MTF2	22823	broad.mit.edu	37	1	93599773	93599773	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:93599773delT	uc009wdj.2	+						MTF2_uc010oth.1_Intron|MTF2_uc009wdk.2_Intron|MTF2_uc001dpi.3_Intron|MTF2_uc010oti.1_Intron|MTF2_uc001dpj.3_Intron|MTF2_uc001dpl.3_Intron|MTF2_uc001dpm.3_Intron	NM_007358	NP_031384			metal response element binding transcription							nucleus	DNA binding|zinc ion binding			ovary(2)	2		all_lung(203;0.00196)|Lung NSC(277;0.00902)|Melanoma(281;0.099)|Ovarian(761;0.109)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00076)|GBM - Glioblastoma multiforme(16;0.00157)|Epithelial(280;0.0886)														---	---	---	---
CCDC18	343099	broad.mit.edu	37	1	93722149	93722149	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:93722149delT	uc001dpq.2	+						CCDC18_uc001dpr.1_Intron	NM_206886	NP_996769			sarcoma antigen NY-SAR-41											ovary(2)|breast(2)|pancreas(1)	5		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)														---	---	---	---
DR1	1810	broad.mit.edu	37	1	93826024	93826024	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:93826024delT	uc001dpu.2	+						DR1_uc010otj.1_Intron	NM_001938	NP_001929			down-regulator of transcription 1						histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Ada2/Gcn5/Ada3 transcription activator complex	sequence-specific DNA binding|TBP-class protein binding|transcription corepressor activity				0		all_lung(203;0.00252)|Lung NSC(277;0.011)|Melanoma(281;0.155)		all cancers(265;0.0032)|GBM - Glioblastoma multiforme(16;0.0165)|Epithelial(280;0.0977)														---	---	---	---
Unknown	0	broad.mit.edu	37	1	96914049	96914049	+	IGR	DEL	C	-	-	rs1931180	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:96914049delC								None (None upstream) : PTBP2 (273126 downstream)																																			---	---	---	---
PTBP2	58155	broad.mit.edu	37	1	97243528	97243528	+	Intron	DEL	T	-	-	rs35880836		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:97243528delT	uc001drq.2	+						PTBP2_uc001drn.2_Intron|PTBP2_uc001dro.2_Intron|PTBP2_uc010otz.1_Intron|PTBP2_uc001drp.2_Intron|PTBP2_uc009wdw.2_Intron|PTBP2_uc001drr.2_Intron|PTBP2_uc010oua.1_Intron|PTBP2_uc001dru.2_Intron	NM_021190	NP_067013			polypyrimidine tract binding protein 2								nucleotide binding				0		all_epithelial(167;2.95e-05)|all_lung(203;0.000396)|Lung NSC(277;0.00171)		all cancers(265;0.0582)|Epithelial(280;0.0716)|Colorectal(170;0.0879)|KIRC - Kidney renal clear cell carcinoma(1967;0.202)														---	---	---	---
SASS6	163786	broad.mit.edu	37	1	100584676	100584676	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:100584676delT	uc001dsu.2	-	7	708	c.567delA	c.(565-567)AAAfs	p.K189fs	SASS6_uc009wdz.2_Frame_Shift_Del_p.K22fs	NM_194292	NP_919268	Q6UVJ0	SAS6_HUMAN	spindle assembly abnormal protein 6	189	Potential.				centriole replication	centriole				upper_aerodigestive_tract(1)|ovary(1)	2		all_epithelial(167;4.58e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.085)|all cancers(265;0.139)|COAD - Colon adenocarcinoma(174;0.15)|Lung(183;0.197)														---	---	---	---
CCDC76	54482	broad.mit.edu	37	1	100614483	100614483	+	3'UTR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:100614483delA	uc001dsv.2	+	11					CCDC76_uc010ouf.1_RNA|CCDC76_uc009wea.2_3'UTR|LRRC39_uc001dsw.1_3'UTR|LRRC39_uc001dsx.1_3'UTR|LRRC39_uc001dsy.1_3'UTR|LRRC39_uc001dsz.1_3'UTR	NM_019083	NP_061956			coiled-coil domain containing 76						tRNA processing		metal ion binding|methyltransferase activity			ovary(1)	1		all_epithelial(167;0.000542)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0814)|all cancers(265;0.133)|COAD - Colon adenocarcinoma(174;0.146)|Lung(183;0.194)														---	---	---	---
EXTL2	2135	broad.mit.edu	37	1	101354290	101354290	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:101354290delA	uc001dtk.1	-						EXTL2_uc001dtl.1_Intron|EXTL2_uc010ouk.1_Intron|EXTL2_uc001dtm.1_Intron	NM_001439	NP_001430			exostoses-like 2						N-acetylglucosamine metabolic process|UDP-N-acetylgalactosamine metabolic process	extracellular region|integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,4-N-acetylgalactosaminyltransferase activity|glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding			skin(1)	1		all_epithelial(167;2.48e-06)|all_lung(203;0.000414)|Lung NSC(277;0.000946)		Epithelial(280;0.0425)|all cancers(265;0.0628)|COAD - Colon adenocarcinoma(174;0.148)|Colorectal(144;0.167)|Lung(183;0.195)														---	---	---	---
COL11A1	1301	broad.mit.edu	37	1	103473926	103473926	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:103473926delA	uc001dul.2	-						COL11A1_uc001duk.2_Intron|COL11A1_uc001dum.2_Intron|COL11A1_uc001dun.2_Intron|COL11A1_uc009weh.2_Intron	NM_001854	NP_001845			alpha 1 type XI collagen isoform A						collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)														---	---	---	---
KIAA1324	57535	broad.mit.edu	37	1	109706947	109706947	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:109706947delT	uc001dwq.2	+						KIAA1324_uc009wex.1_Intron|KIAA1324_uc009wey.2_Intron|KIAA1324_uc010ovg.1_Intron	NM_020775	NP_065826			hypothetical protein LOC57535 precursor						macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	5		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)														---	---	---	---
GSTM2	2946	broad.mit.edu	37	1	110217357	110217357	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:110217357delC	uc001dyi.2	+						GSTM2_uc001dyj.2_Intron|GSTM2_uc010ovt.1_Intron|GSTM2_uc009wfk.2_Intron	NM_000848	NP_000839			glutathione S-transferase mu 2 isoform 1						glutathione metabolic process|xenobiotic catabolic process	cytoplasm	glutathione transferase activity				0		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		all cancers(265;0.0122)|Colorectal(144;0.0129)|Epithelial(280;0.0146)|Lung(183;0.0422)|COAD - Colon adenocarcinoma(174;0.047)|LUSC - Lung squamous cell carcinoma(189;0.227)	Glutathione(DB00143)													---	---	---	---
FAM40A	85369	broad.mit.edu	37	1	110589510	110589511	+	Intron	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:110589510_110589511delAA	uc001dza.1	+						FAM40A_uc001dyz.1_Intron|FAM40A_uc009wfp.1_Intron	NM_033088	NP_149079			hypothetical protein LOC85369							nucleus	protein binding			ovary(3)|large_intestine(1)	4		all_cancers(81;8.51e-05)|all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0154)|all cancers(265;0.0732)|Epithelial(280;0.0781)|Colorectal(144;0.115)|LUSC - Lung squamous cell carcinoma(189;0.137)														---	---	---	---
RBM15	64783	broad.mit.edu	37	1	110889132	110889132	+	3'UTR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:110889132delA	uc001dzl.1	+	3					RBM15_uc001dzm.1_3'UTR|uc001dzn.1_5'Flank	NM_022768	NP_073605			RNA binding motif protein 15						interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)				T	MKL1	acute megakaryocytic leukemia								---	---	---	---
DRAM2	128338	broad.mit.edu	37	1	111667640	111667641	+	Intron	DEL	AA	-	-	rs146295738		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:111667640_111667641delAA	uc001ead.3	-						DRAM2_uc001eae.3_Intron|DRAM2_uc009wfy.2_Intron|DRAM2_uc001eaf.3_Intron	NM_178454	NP_848549			transmembrane protein 77						apoptosis|induction of apoptosis	Golgi apparatus|integral to membrane|lysosomal membrane					0																		---	---	---	---
CEPT1	10390	broad.mit.edu	37	1	111690320	111690320	+	5'UTR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:111690320delA	uc001eah.1	+	2					CEPT1_uc001eag.2_5'UTR|CEPT1_uc001eai.1_5'UTR|CEPT1_uc001eaj.1_5'UTR	NM_001007794	NP_001007795			choline/ethanolaminephosphotransferase							endoplasmic reticulum membrane|integral to membrane|nuclear membrane	diacylglycerol cholinephosphotransferase activity|ethanolaminephosphotransferase activity|metal ion binding				0		all_cancers(81;2.27e-05)|all_epithelial(167;7.36e-06)|all_lung(203;0.00018)|Lung NSC(277;0.000359)		Lung(183;0.0173)|Colorectal(144;0.0375)|all cancers(265;0.0701)|LUSC - Lung squamous cell carcinoma(189;0.0888)|Epithelial(280;0.103)|COAD - Colon adenocarcinoma(174;0.141)	Choline(DB00122)													---	---	---	---
WDR77	79084	broad.mit.edu	37	1	111989532	111989532	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:111989532delA	uc001ebb.2	-						WDR77_uc010owd.1_Intron|WDR77_uc010owe.1_Intron|ATP5F1_uc009wgf.1_5'Flank|ATP5F1_uc001ebc.2_5'Flank|ATP5F1_uc001ebd.3_5'Flank	NM_024102	NP_077007			WD repeat domain 77						ncRNA metabolic process|spliceosomal snRNP assembly	cytosol|nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding				0		all_cancers(81;0.000902)|all_epithelial(167;0.00056)|all_lung(203;0.00277)|Lung NSC(277;0.0043)		Lung(183;0.0238)|Colorectal(144;0.0296)|all cancers(265;0.0488)|Epithelial(280;0.0732)|COAD - Colon adenocarcinoma(174;0.114)|LUSC - Lung squamous cell carcinoma(189;0.135)														---	---	---	---
LRIG2	9860	broad.mit.edu	37	1	113635953	113635953	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:113635953delT	uc001edf.1	+						LRIG2_uc009wgn.1_Intron	NM_014813	NP_055628			leucine-rich repeats and immunoglobulin-like							cytoplasm|integral to membrane|plasma membrane				ovary(3)	3	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)														---	---	---	---
PTPN22	26191	broad.mit.edu	37	1	114400511	114400511	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:114400511delT	uc001eds.2	-						uc001edv.1_Intron|PTPN22_uc009wgq.2_Intron|PTPN22_uc010owo.1_Intron|PTPN22_uc001edt.2_Intron|PTPN22_uc009wgr.2_Intron|PTPN22_uc009wgs.2_Intron|PTPN22_uc001edu.2_Intron	NM_015967	NP_057051			protein tyrosine phosphatase, non-receptor type						negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			kidney(2)|lung(1)|skin(1)	4	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)														---	---	---	---
TRIM33	51592	broad.mit.edu	37	1	114969991	114969991	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:114969991delA	uc001eew.2	-						TRIM33_uc010owr.1_Intron|TRIM33_uc010ows.1_Intron|TRIM33_uc001eex.2_Intron	NM_015906	NP_056990			tripartite motif-containing 33 protein isoform						negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	nucleus	co-SMAD binding|DNA binding|ligase activity|R-SMAD binding|zinc ion binding			lung(4)|central_nervous_system(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	11	all_epithelial(7;0.000132)|all_lung(7;0.00106)|Lung SC(450;0.184)	all_cancers(81;3.03e-08)|all_epithelial(167;3.24e-08)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)				T	RET	papillary thyroid								---	---	---	---
DENND2C	163259	broad.mit.edu	37	1	115142747	115142747	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:115142747delA	uc001efd.1	-						DENND2C_uc001eez.2_Intron|DENND2C_uc001efc.1_Intron	NM_198459	NP_940861			DENN/MADD domain containing 2C											skin(3)	3	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)														---	---	---	---
CSDE1	7812	broad.mit.edu	37	1	115279333	115279334	+	Intron	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:115279333_115279334delAA	uc001efk.2	-						CSDE1_uc001efi.2_Intron|CSDE1_uc001efj.2_Intron|CSDE1_uc001efl.2_Intron|CSDE1_uc001efm.2_Intron|CSDE1_uc009wgv.2_Intron|CSDE1_uc001efn.2_Intron	NM_001007553	NP_001007554			upstream of NRAS isoform 1						male gonad development|regulation of transcription, DNA-dependent	cytoplasm	DNA binding|protein binding|RNA binding			ovary(1)	1	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;2.21e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)														---	---	---	---
CSDE1	7812	broad.mit.edu	37	1	115279937	115279938	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:115279937_115279938insT	uc001efk.2	-						CSDE1_uc001efi.2_Intron|CSDE1_uc001efj.2_Intron|CSDE1_uc001efl.2_Intron|CSDE1_uc001efm.2_Intron|CSDE1_uc009wgv.2_Intron|CSDE1_uc001efn.2_Intron	NM_001007553	NP_001007554			upstream of NRAS isoform 1						male gonad development|regulation of transcription, DNA-dependent	cytoplasm	DNA binding|protein binding|RNA binding			ovary(1)	1	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;2.21e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)														---	---	---	---
SLC22A15	55356	broad.mit.edu	37	1	116570251	116570251	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:116570251delT	uc001egb.3	+						SLC22A15_uc001ega.2_Intron	NM_018420	NP_060890			solute carrier family 22, member 15						ion transport	integral to membrane	transmembrane transporter activity			large_intestine(2)	2	Lung SC(450;0.184)	all_cancers(81;3.17e-06)|all_epithelial(167;2.32e-06)|all_lung(203;9.81e-06)|Lung NSC(69;5.94e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)														---	---	---	---
TTF2	8458	broad.mit.edu	37	1	117644387	117644387	+	3'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:117644387delT	uc001egy.2	+	23						NM_003594	NP_003585			transcription termination factor, RNA polymerase						mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|termination of RNA polymerase II transcription	cytoplasm|spliceosomal complex|transcription elongation factor complex	ATP binding|ATP-dependent helicase activity|DNA binding|DNA-dependent ATPase activity|protein binding|zinc ion binding			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;4.23e-06)|all_epithelial(167;3.65e-07)|all_lung(203;2.81e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0553)|Colorectal(144;0.179)|LUSC - Lung squamous cell carcinoma(189;0.19)														---	---	---	---
WDR3	10885	broad.mit.edu	37	1	118496253	118496253	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:118496253delT	uc010oxe.1	+						WDR3_uc001ehi.2_Intron	NM_006784	NP_006775			WD repeat-containing protein 3							nuclear membrane|nucleolus				upper_aerodigestive_tract(1)	1	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)														---	---	---	---
SPAG17	200162	broad.mit.edu	37	1	118537093	118537093	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:118537093delT	uc001ehk.2	-	35	5182	c.5114delA	c.(5113-5115)AAGfs	p.K1705fs		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1705						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)														---	---	---	---
PDZK1	5174	broad.mit.edu	37	1	145762320	145762320	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:145762320delA	uc001eon.1	+	9	1594	c.1497delA	c.(1495-1497)GCAfs	p.A499fs	NBPF10_uc001emp.3_Intron|PDZK1_uc001eoo.1_Frame_Shift_Del_p.A499fs|PDZK1_uc010oza.1_Frame_Shift_Del_p.A388fs	NM_002614	NP_002605	Q5T2W1	NHRF3_HUMAN	PDZ domain containing 1	499					carnitine transport|cell proliferation|drug transport|positive regulation of ion transmembrane transport	brush border membrane|cytoplasm	PDZ domain binding|transporter activity				0	all_hematologic(18;0.00473)|Acute lymphoblastic leukemia(18;0.0786)		KIRC - Kidney renal clear cell carcinoma(6;0.0764)|Kidney(552;0.118)|Colorectal(543;0.229)															---	---	---	---
CHD1L	9557	broad.mit.edu	37	1	146731281	146731281	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:146731281delA	uc001epm.3	+						uc001epp.2_RNA|CHD1L_uc001epn.3_Intron|CHD1L_uc010ozo.1_Intron|CHD1L_uc009wjg.2_Intron|CHD1L_uc009wjh.2_Intron|CHD1L_uc010ozp.1_Intron|CHD1L_uc001epo.3_Intron	NM_004284	NP_004275			chromodomain helicase DNA binding protein						chromatin remodeling|DNA repair	cytoplasm|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(3)|lung(2)|upper_aerodigestive_tract(1)	6	all_hematologic(923;0.0487)																	---	---	---	---
SV2A	9900	broad.mit.edu	37	1	149884981	149884981	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:149884981delC	uc001etg.2	-	2	903	c.412delG	c.(412-414)GAGfs	p.E138fs	SV2A_uc001eth.2_Frame_Shift_Del_p.E138fs	NM_014849	NP_055664	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2	138	Cytoplasmic (Potential).				neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(6)|pancreas(1)	7	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)													---	---	---	---
ANP32E	81611	broad.mit.edu	37	1	150195337	150195337	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:150195337delA	uc001etw.2	-						ANP32E_uc010pbt.1_Intron|ANP32E_uc010pbu.1_Intron|ANP32E_uc010pbv.1_Intron|ANP32E_uc001etv.3_Intron	NM_030920	NP_112182			acidic (leucine-rich) nuclear phosphoprotein 32							cytoplasmic membrane-bounded vesicle|nucleus	phosphatase inhibitor activity				0	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)															---	---	---	---
ADAMTSL4	54507	broad.mit.edu	37	1	150526845	150526846	+	Frame_Shift_Ins	INS	-	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:150526845_150526846insC	uc001eux.2	+	7	1372_1373	c.1136_1137insC	c.(1135-1137)TGCfs	p.C379fs	ADAMTSL4_uc001euw.2_Frame_Shift_Ins_p.C379fs|ADAMTSL4_uc009wlw.2_Frame_Shift_Ins_p.C379fs|ADAMTSL4_uc010pcg.1_Frame_Shift_Ins_p.C379fs	NM_019032	NP_061905	Q6UY14	ATL4_HUMAN	thrombospondin repeat containing 1 isoform 1	379					apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			ovary(1)|skin(1)	2	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)															---	---	---	---
PRUNE	58497	broad.mit.edu	37	1	150990220	150990220	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:150990220delA	uc001ewh.1	+						PRUNE_uc001ewi.1_Intron|PRUNE_uc010pco.1_Intron|PRUNE_uc001ewj.1_Intron	NM_021222	NP_067045			prune							cytoplasm|focal adhesion|nucleus	inorganic diphosphatase activity|manganese ion binding|protein binding			ovary(1)	1	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)															---	---	---	---
POGZ	23126	broad.mit.edu	37	1	151380627	151380628	+	Frame_Shift_Del	DEL	AG	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:151380627_151380628delAG	uc001eyd.1	-	15	2629_2630	c.2323_2324delCT	c.(2323-2325)CTGfs	p.L775fs	POGZ_uc001eye.1_Frame_Shift_Del_p.L722fs|POGZ_uc010pdb.1_Frame_Shift_Del_p.L766fs|POGZ_uc001eyf.1_Frame_Shift_Del_p.L731fs|POGZ_uc010pdc.1_Frame_Shift_Del_p.L713fs|POGZ_uc009wmv.1_Frame_Shift_Del_p.L680fs|POGZ_uc010pdd.1_Frame_Shift_Del_p.L266fs	NM_015100	NP_055915	Q7Z3K3	POGZ_HUMAN	pogo transposable element with ZNF domain	775	C2H2-type 8.				cell division|kinetochore assembly|mitotic sister chromatid cohesion|regulation of transcription, DNA-dependent	cytoplasm|nuclear chromatin	DNA binding|protein binding|zinc ion binding			ovary(3)	3	Lung SC(34;0.00471)|Ovarian(49;0.00672)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)															---	---	---	---
S100A11	6282	broad.mit.edu	37	1	152009330	152009330	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:152009330delT	uc001ezn.2	-						uc001ezm.1_Intron	NM_005620	NP_005611			S100 calcium binding protein A11						negative regulation of cell proliferation|negative regulation of DNA replication|signal transduction	cytoplasm|nucleus|ruffle	calcium ion binding|calcium-dependent protein binding|protein homodimerization activity|S100 beta binding				0	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)															---	---	---	---
LCE1C	353133	broad.mit.edu	37	1	152777650	152777650	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:152777650delC	uc001fap.1	-	2	356	c.305delG	c.(304-306)GGCfs	p.G102fs		NM_178351	NP_848128	Q5T751	LCE1C_HUMAN	late cornified envelope 1C	102	Gly-rich.				keratinization						0	Lung NSC(65;9.06e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)															---	---	---	---
NUP210L	91181	broad.mit.edu	37	1	154090060	154090061	+	Intron	INS	-	A	A	rs79748906		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:154090060_154090061insA	uc001fdw.2	-						NUP210L_uc009woq.2_Intron|NUP210L_uc010peh.1_Intron	NM_207308	NP_997191			nucleoporin 210kDa-like isoform 1							integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)															---	---	---	---
UBAP2L	9898	broad.mit.edu	37	1	154215938	154215938	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:154215938delT	uc001fep.3	+						UBAP2L_uc009wot.2_Intron|UBAP2L_uc010pek.1_Intron|UBAP2L_uc010pel.1_Intron|UBAP2L_uc010pen.1_Intron	NM_014847	NP_055662			ubiquitin associated protein 2-like isoform a						binding of sperm to zona pellucida		protein binding			ovary(1)|central_nervous_system(1)	2	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)															---	---	---	---
PBXIP1	57326	broad.mit.edu	37	1	154924035	154924035	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:154924035delA	uc001ffr.2	-						PBXIP1_uc001ffs.2_Intron|PBXIP1_uc010pep.1_Intron|PBXIP1_uc009woy.1_Intron	NM_020524	NP_065385			pre-B-cell leukemia homeobox interacting protein						cell differentiation|multicellular organismal development|negative regulation of transcription, DNA-dependent	cytosol|microtubule|nucleus	protein binding|transcription corepressor activity			large_intestine(1)	1	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)															---	---	---	---
FAM189B	10712	broad.mit.edu	37	1	155220390	155220390	+	Frame_Shift_Del	DEL	G	-	-	rs74953707	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:155220390delG	uc001fjm.2	-	9	1793	c.1187delC	c.(1186-1188)CCAfs	p.P396fs	RAG1AP1_uc010pey.1_Intron|FAM189B_uc009wql.2_Frame_Shift_Del_p.P198fs|FAM189B_uc001fjn.2_Frame_Shift_Del_p.P300fs|FAM189B_uc001fjo.2_Frame_Shift_Del_p.P378fs|FAM189B_uc001fjp.2_Intron	NM_006589	NP_006580	P81408	F189B_HUMAN	hypothetical protein LOC10712 isoform a	396						integral to membrane	WW domain binding			ovary(1)|breast(1)	2																		---	---	---	---
PKLR	5313	broad.mit.edu	37	1	155269709	155269710	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:155269709_155269710insT	uc001fkb.3	-						RAG1AP1_uc010pey.1_Intron|PKLR_uc001fka.3_Intron|PKLR_uc010pga.1_Intron	NM_000298	NP_000289			pyruvate kinase, liver and RBC isoform 1						endocrine pancreas development|energy reserve metabolic process|glycolysis|positive regulation of cellular metabolic process	cytosol	ATP binding|magnesium ion binding|potassium ion binding|pyruvate kinase activity			skin(4)|ovary(1)	5	all_lung(78;6.99e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;3.18e-10)|all cancers(21;7.9e-10)|BRCA - Breast invasive adenocarcinoma(34;0.00116)|LUSC - Lung squamous cell carcinoma(543;0.127)		Pyruvic acid(DB00119)													---	---	---	---
DAP3	7818	broad.mit.edu	37	1	155697260	155697262	+	Intron	DEL	AAA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:155697260_155697262delAAA	uc001flq.2	+						DAP3_uc001flr.2_Intron|DAP3_uc001fls.2_Intron|DAP3_uc010pgl.1_Intron|DAP3_uc001flt.2_Intron|DAP3_uc001flu.2_Intron|DAP3_uc010pgm.1_Intron	NM_033657	NP_387506			death-associated protein 3						induction of apoptosis by extracellular signals	mitochondrial ribosome|nucleolus|small ribosomal subunit	protein binding			ovary(1)	1	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)																	---	---	---	---
DAP3	7818	broad.mit.edu	37	1	155701653	155701653	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:155701653delA	uc001flq.2	+						DAP3_uc001flr.2_Intron|DAP3_uc001fls.2_Intron|DAP3_uc010pgl.1_Intron|DAP3_uc001flt.2_Intron|DAP3_uc001flu.2_Intron|DAP3_uc010pgm.1_Intron	NM_033657	NP_387506			death-associated protein 3						induction of apoptosis by extracellular signals	mitochondrial ribosome|nucleolus|small ribosomal subunit	protein binding			ovary(1)	1	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)																	---	---	---	---
GON4L	54856	broad.mit.edu	37	1	155822905	155822905	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:155822905delA	uc001flz.2	-						GON4L_uc001fly.1_Intron|GON4L_uc009wrh.1_Intron|GON4L_uc001fma.1_Intron|GON4L_uc001fmc.2_Intron|GON4L_uc001fmd.3_Intron|GON4L_uc009wri.2_Intron	NM_001037533	NP_001032622			gon-4-like isoform a						regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(3)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)																	---	---	---	---
C1orf66	51093	broad.mit.edu	37	1	156702951	156702952	+	Intron	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156702951_156702952delTT	uc001fpu.2	+						C1orf66_uc001fpv.2_Intron	NM_015997	NP_057081			hypothetical protein LOC51093 isoform 1							integral to membrane	rRNA (adenine-N6,N6-)-dimethyltransferase activity				0	all_hematologic(923;0.088)|Hepatocellular(266;0.158)																	---	---	---	---
FCRL3	115352	broad.mit.edu	37	1	157666960	157666960	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:157666960delT	uc001frb.2	-	6	1106	c.814delA	c.(814-816)AGGfs	p.R272fs	FCRL3_uc001fqx.3_RNA|FCRL3_uc001fqy.3_RNA|FCRL3_uc001fqz.3_Frame_Shift_Del_p.R272fs|FCRL3_uc009wsn.2_Intron|FCRL3_uc009wso.2_RNA|FCRL3_uc001fra.2_5'UTR|FCRL3_uc001frc.1_Frame_Shift_Del_p.R272fs	NM_052939	NP_443171	Q96P31	FCRL3_HUMAN	Fc receptor-like 3 precursor	272	Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(1)	4	all_hematologic(112;0.0378)																	---	---	---	---
Unknown	0	broad.mit.edu	37	1	158146153	158146153	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:158146153delT								KIRREL (80311 upstream) : CD1D (3584 downstream)																																			---	---	---	---
OR10T2	128360	broad.mit.edu	37	1	158369265	158369267	+	5'Flank	DEL	CTT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:158369265_158369267delCTT	uc010pih.1	-							NM_001004475	NP_001004475			olfactory receptor, family 10, subfamily T,						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	all_hematologic(112;0.0378)																	---	---	---	---
CCDC19	25790	broad.mit.edu	37	1	159856131	159856131	+	Intron	DEL	A	-	-	rs113465282		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:159856131delA	uc001fui.2	-						CCDC19_uc009wtb.2_Intron|CCDC19_uc001fuj.2_Intron|CCDC19_uc001fuk.2_Intron|CCDC19_uc001ful.2_Intron|CCDC19_uc009wtc.1_Intron	NM_012337	NP_036469			nasopharyngeal epithelium specific protein 1							mitochondrion|soluble fraction				ovary(1)	1	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)															---	---	---	---
KLHDC9	126823	broad.mit.edu	37	1	161069611	161069611	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:161069611delG	uc001fxr.2	+						KLHDC9_uc001fxq.2_Intron|KLHDC9_uc001fxs.2_Intron	NM_152366	NP_689579			kelch/ankyrin repeat containing cyclin A1												0	all_cancers(52;1.28e-19)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)															---	---	---	---
FCRLB	127943	broad.mit.edu	37	1	161697453	161697453	+	3'UTR	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:161697453delG	uc001gbh.2	+	8					FCRLB_uc009wus.2_3'UTR|FCRLB_uc001gbj.2_3'UTR|FCRLB_uc001gbk.2_3'UTR|FCRLB_uc001gbl.2_3'UTR|FCRLB_uc001gbm.2_3'UTR|FCRLB_uc001gbi.2_3'UTR|FCRLB_uc001gbn.3_3'UTR	NM_001002901	NP_001002901			Fc receptor-like B							endoplasmic reticulum					0	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)															---	---	---	---
HSD17B7	51478	broad.mit.edu	37	1	162782018	162782018	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:162782018delT	uc001gci.2	+						HSD17B7_uc009wuv.2_Intron	NM_016371	NP_057455			hydroxysteroid (17-beta) dehydrogenase 7						cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	3-keto sterol reductase activity|estradiol 17-beta-dehydrogenase activity			ovary(1)	1	all_hematologic(112;0.115)				NADH(DB00157)													---	---	---	---
UCK2	7371	broad.mit.edu	37	1	165877195	165877195	+	3'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:165877195delT	uc001gdp.2	+	7					UCK2_uc010plb.1_3'UTR	NM_012474	NP_036606			uridine-cytidine kinase 2						pyrimidine base metabolic process|pyrimidine nucleoside salvage	cytosol	ATP binding|phosphotransferase activity, alcohol group as acceptor|uridine kinase activity			ovary(1)	1	all_hematologic(923;0.048)|Acute lymphoblastic leukemia(8;0.155)																	---	---	---	---
ILDR2	387597	broad.mit.edu	37	1	166944274	166944279	+	Intron	DEL	CACACA	-	-	rs67253020		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:166944274_166944279delCACACA	uc001gdx.1	-							NM_199351	NP_955383			immunoglobulin-like domain containing receptor							integral to membrane				ovary(1)	1																		---	---	---	---
RCSD1	92241	broad.mit.edu	37	1	167666290	167666290	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:167666290delT	uc001gem.2	+						RCSD1_uc010pli.1_Intron	NM_052862	NP_443094			RCSD domain containing 1											ovary(2)|central_nervous_system(2)|skin(1)	5	all_hematologic(923;0.215)																	---	---	---	---
ADCY10	55811	broad.mit.edu	37	1	167791383	167791384	+	Intron	DEL	AG	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:167791383_167791384delAG	uc001ger.2	-						ADCY10_uc009wvj.2_Intron|ADCY10_uc009wvk.2_Intron|ADCY10_uc010plj.1_Intron	NM_018417	NP_060887			adenylate cyclase 10						intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3																		---	---	---	---
TBX19	9095	broad.mit.edu	37	1	168215647	168215647	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:168215647delT	uc001gfj.3	+						ANKRD36BP1_uc010plo.1_RNA|uc001gfk.1_5'Flank	NM_005149	NP_005140			T-box 19						anatomical structure morphogenesis	nucleus	DNA binding				0	all_hematologic(923;0.215)																	---	---	---	---
ATP1B1	481	broad.mit.edu	37	1	169080508	169080508	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:169080508delG	uc001gfs.1	+											Synthetic construct DNA, clone: pF1KB8186, Homo sapiens ATP1B1 gene for ATPase, Na+/K+ transporting, beta 1 polypeptide, without stop codon, in Flexi system.						ATP biosynthetic process|blood coagulation|leukocyte migration	sodium:potassium-exchanging ATPase complex	protein binding|sodium:potassium-exchanging ATPase activity			ovary(1)	1	all_hematologic(923;0.208)																	---	---	---	---
F5	2153	broad.mit.edu	37	1	169484870	169484870	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:169484870delA	uc001ggg.1	-							NM_000130	NP_000121			coagulation factor V precursor						cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)													---	---	---	---
SCYL3	57147	broad.mit.edu	37	1	169822809	169822809	+	3'UTR	DEL	A	-	-	rs35116293		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:169822809delA	uc001ggs.2	-	14					SCYL3_uc010plw.1_3'UTR|SCYL3_uc001ggt.2_3'UTR|SCYL3_uc001ggu.2_RNA	NM_181093	NP_851607			SCY1-like 3 isoform 2						cell migration	Golgi apparatus|lamellipodium	ATP binding|protein binding|protein kinase activity			ovary(1)|skin(1)	2	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)																	---	---	---	---
SCYL3	57147	broad.mit.edu	37	1	169823174	169823174	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:169823174delT	uc001ggs.2	-						SCYL3_uc010plw.1_Intron|SCYL3_uc001ggt.2_Intron|SCYL3_uc001ggu.2_Intron	NM_181093	NP_851607			SCY1-like 3 isoform 2						cell migration	Golgi apparatus|lamellipodium	ATP binding|protein binding|protein kinase activity			ovary(1)|skin(1)	2	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)																	---	---	---	---
KIFAP3	22920	broad.mit.edu	37	1	169930005	169930006	+	Intron	INS	-	A	A	rs140237252	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:169930005_169930006insA	uc001ggv.2	-						KIFAP3_uc010plx.1_Intron	NM_014970	NP_055785			kinesin-associated protein 3						blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)																	---	---	---	---
VAMP4	8674	broad.mit.edu	37	1	171697649	171697650	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:171697649_171697650insA	uc001ghx.1	-						VAMP4_uc001ghw.1_Intron|VAMP4_uc001ghy.1_Intron	NM_003762	NP_003753			vesicle-associated membrane protein 4						vesicle-mediated transport	endosome|Golgi membrane|integral to membrane|lysosome					0	all_cancers(6;1.42e-10)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)																	---	---	---	---
DARS2	55157	broad.mit.edu	37	1	173807553	173807553	+	Intron	DEL	T	-	-	rs111398321		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:173807553delT	uc001gjh.1	+							NM_018122	NP_060592			aspartyl-tRNA synthetase 2, mitochondrial						tRNA aminoacylation for protein translation	mitochondrial matrix|nucleus	aspartate-tRNA ligase activity|ATP binding|nucleic acid binding			central_nervous_system(2)	2					L-Aspartic Acid(DB00128)													---	---	---	---
GPR52	9293	broad.mit.edu	37	1	174418476	174418476	+	3'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:174418476delT	uc001gka.1	+	1					RABGAP1L_uc001gjw.2_Intron|RABGAP1L_uc001gjx.2_Intron|RABGAP1L_uc001gjy.2_Intron|RABGAP1L_uc001gjz.2_Intron|uc010pmu.1_5'Flank	NM_005684	NP_005675			G protein-coupled receptor 52							integral to plasma membrane	G-protein coupled receptor activity			skin(1)	1																		---	---	---	---
RABGAP1L	9910	broad.mit.edu	37	1	174606695	174606695	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:174606695delT	uc001gjx.2	+							NM_014857	NP_055672			RAB GTPase activating protein 1-like isoform A						regulation of protein localization	early endosome|Golgi apparatus|nucleus	Rab GTPase activator activity			ovary(2)|lung(1)|kidney(1)	4																		---	---	---	---
RFWD2	64326	broad.mit.edu	37	1	175958359	175958360	+	Intron	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:175958359_175958360delAA	uc001gku.1	-						RFWD2_uc001gkv.1_Intron|RFWD2_uc001gkw.1_Intron|RFWD2_uc009wwv.2_Intron|RFWD2_uc001gkt.1_Intron	NM_022457	NP_071902			ring finger and WD repeat domain 2 isoform a						DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	centrosome|cytosol|focal adhesion|nuclear speck	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0																		---	---	---	---
PAPPA2	60676	broad.mit.edu	37	1	176708639	176708639	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:176708639delA	uc001gkz.2	+						PAPPA2_uc009www.2_Intron	NM_020318	NP_064714			pappalysin 2 isoform 1						cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16																		---	---	---	---
PAPPA2	60676	broad.mit.edu	37	1	176762724	176762724	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:176762724delC	uc001gkz.2	+	20	6213	c.5049delC	c.(5047-5049)ATCfs	p.I1683fs	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1683	Sushi 5.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16																		---	---	---	---
RASAL2	9462	broad.mit.edu	37	1	178411757	178411757	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:178411757delT	uc001glr.2	+						RASAL2_uc001glq.2_Intron	NM_004841	NP_004832			RAS protein activator like 2 isoform 1						negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			ovary(2)|breast(2)|large_intestine(1)	5																		---	---	---	---
RALGPS2	55103	broad.mit.edu	37	1	178746076	178746076	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:178746076delT	uc001glz.2	+						RALGPS2_uc001gly.1_Intron|RALGPS2_uc010pnb.1_Intron	NM_152663	NP_689876			Ral GEF with PH domain and SH3 binding motif 2						small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity|protein binding				0																		---	---	---	---
RALGPS2	55103	broad.mit.edu	37	1	178790728	178790728	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:178790728delT	uc001glz.2	+						RALGPS2_uc001gly.1_Intron|RALGPS2_uc010pnb.1_Intron	NM_152663	NP_689876			Ral GEF with PH domain and SH3 binding motif 2						small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity|protein binding				0																		---	---	---	---
CEP350	9857	broad.mit.edu	37	1	179961369	179961369	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:179961369delA	uc001gnt.2	+						CEP350_uc001gnr.1_Intron|CEP350_uc009wxl.2_Intron	NM_014810	NP_055625			centrosome-associated protein 350							centrosome|nucleus|spindle				ovary(4)	4																		---	---	---	---
CEP350	9857	broad.mit.edu	37	1	179984861	179984861	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:179984861delA	uc001gnt.2	+						CEP350_uc009wxl.2_Intron|CEP350_uc001gnu.2_Intron	NM_014810	NP_055625			centrosome-associated protein 350							centrosome|nucleus|spindle				ovary(4)	4																		---	---	---	---
XPR1	9213	broad.mit.edu	37	1	180805950	180805950	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:180805950delT	uc001goi.2	+						XPR1_uc009wxn.2_Intron	NM_004736	NP_004727			xenotropic and polytropic retrovirus receptor							integral to plasma membrane	G-protein coupled receptor activity				0																		---	---	---	---
HMCN1	83872	broad.mit.edu	37	1	186083133	186083133	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:186083133delC	uc001grq.1	+	73	11383	c.11154delC	c.(11152-11154)GGCfs	p.G3718fs		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	3718	Ig-like C2-type 36.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23																		---	---	---	---
PRG4	10216	broad.mit.edu	37	1	186278399	186278399	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:186278399delT	uc001gru.3	+						PRG4_uc001grt.3_Intron|PRG4_uc009wyl.2_Intron|PRG4_uc009wym.2_Intron|PRG4_uc010poo.1_Intron	NM_005807	NP_005798			proteoglycan 4 isoform A						cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1																		---	---	---	---
C1orf27	54953	broad.mit.edu	37	1	186357524	186357525	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:186357524_186357525insT	uc001grw.2	+						C1orf27_uc010poq.1_Intron|C1orf27_uc010por.1_Intron	NM_017847	NP_060317			odorant response abnormal 4 isoform 1							integral to membrane	oxidoreductase activity|zinc ion binding			ovary(1)	1																		---	---	---	---
PDC	5132	broad.mit.edu	37	1	186415429	186415429	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:186415429delT	uc001gsa.2	-						PDC_uc001grz.2_Intron	NM_002597	NP_002588			phosducin isoform a						G-protein coupled receptor protein signaling pathway|phototransduction|visual perception	actin cytoskeleton|cytosol|nucleus|photoreceptor inner segment|photoreceptor outer segment	phospholipase inhibitor activity			skin(1)	1		Breast(1374;1.53e-05)		KIRC - Kidney renal clear cell carcinoma(1967;3.23e-08)|Colorectal(1306;0.0129)														---	---	---	---
PLA2G4A	5321	broad.mit.edu	37	1	186862228	186862228	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:186862228delA	uc001gsc.2	+	4	406	c.201delA	c.(199-201)ATAfs	p.I67fs	PLA2G4A_uc010pos.1_Frame_Shift_Del_p.I67fs	NM_024420	NP_077734	P47712	PA24A_HUMAN	cytosolic phospholipase A2, group IVA	67	C2.|Phospholipid binding (Probable).				phospholipid catabolic process|platelet activating factor biosynthetic process|platelet activation	cytosol|endoplasmic reticulum membrane	calcium ion binding|calcium-dependent phospholipid binding|lysophospholipase activity			lung(2)|breast(1)	3					Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Medrysone(DB00253)|Quinacrine(DB01103)													---	---	---	---
PLA2G4A	5321	broad.mit.edu	37	1	186862505	186862506	+	Intron	INS	-	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:186862505_186862506insC	uc001gsc.2	+						PLA2G4A_uc010pos.1_Intron	NM_024420	NP_077734			cytosolic phospholipase A2, group IVA						phospholipid catabolic process|platelet activating factor biosynthetic process|platelet activation	cytosol|endoplasmic reticulum membrane	calcium ion binding|calcium-dependent phospholipid binding|lysophospholipase activity			lung(2)|breast(1)	3					Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Medrysone(DB00253)|Quinacrine(DB01103)													---	---	---	---
Unknown	0	broad.mit.edu	37	1	189223023	189223026	+	IGR	DEL	TTTT	-	-	rs113290842		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:189223023_189223026delTTTT								None (None upstream) : FAM5C (843771 downstream)																																			---	---	---	---
RGS18	64407	broad.mit.edu	37	1	192128012	192128012	+	Intron	DEL	A	-	-	rs28417375		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:192128012delA	uc001gsg.2	+							NM_130782	NP_570138			regulator of G-protein signalling 18						negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)	3																		---	---	---	---
RGS13	6003	broad.mit.edu	37	1	192613357	192613357	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:192613357delT	uc001gsj.2	+						RGS13_uc001gsk.2_Intron	NM_002927	NP_002918			regulator of G-protein signalling 13							plasma membrane	GTPase activator activity|signal transducer activity				0																		---	---	---	---
TROVE2	6738	broad.mit.edu	37	1	193051443	193051443	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:193051443delT	uc001gss.2	+						TROVE2_uc001gst.1_Intron|TROVE2_uc001gsu.1_Intron|TROVE2_uc001gsv.1_Intron|TROVE2_uc001gsw.2_Intron|TROVE2_uc009wyp.2_Intron|TROVE2_uc009wyq.2_Intron|TROVE2_uc001gsx.1_Intron	NM_004600	NP_004591			TROVE domain family, member 2 isoform 2						transcription from RNA polymerase III promoter	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|RNA binding				0																		---	---	---	---
KCNT2	343450	broad.mit.edu	37	1	196274286	196274286	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:196274286delT	uc001gtd.1	-						KCNT2_uc009wyt.1_Intron|KCNT2_uc001gte.1_Intron|KCNT2_uc001gtf.1_Intron|KCNT2_uc001gtg.1_Intron|KCNT2_uc009wyu.2_Intron|KCNT2_uc001gth.1_Intron	NM_198503	NP_940905			potassium channel, subfamily T, member 2							voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7																		---	---	---	---
CFH	3075	broad.mit.edu	37	1	196658525	196658526	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:196658525_196658526insT	uc001gtj.3	+						CFH_uc001gti.3_Intron|CFH_uc009wyw.2_Intron|CFH_uc009wyx.2_Intron	NM_000186	NP_000177			complement factor H isoform a precursor						complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6																		---	---	---	---
CRB1	23418	broad.mit.edu	37	1	197192530	197192530	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:197192530delT	uc010poz.1	+							NM_201253	NP_957705			crumbs homolog 1 precursor						cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9																		---	---	---	---
DENND1B	163486	broad.mit.edu	37	1	197480840	197480840	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:197480840delA	uc010ppe.1	-						DENND1B_uc010ppf.1_Intron	NM_001142795	NP_001136267			DENN/MADD domain containing 1B isoform 1							clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity				0																		---	---	---	---
DENND1B	163486	broad.mit.edu	37	1	197704547	197704547	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:197704547delA	uc001guf.3	-						DENND1B_uc010ppe.1_Intron|DENND1B_uc010ppf.1_Intron|DENND1B_uc001gue.3_Intron	NM_144977	NP_659414			DENN/MADD domain containing 1B isoform 2							clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity				0																		---	---	---	---
KIF14	9928	broad.mit.edu	37	1	200573204	200573204	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:200573204delT	uc010ppk.1	-						KIF14_uc010ppj.1_Intron	NM_014875	NP_055690			kinesin family member 14						microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			breast(3)|ovary(2)|skin(2)	7																		---	---	---	---
KIF14	9928	broad.mit.edu	37	1	200574276	200574276	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:200574276delA	uc010ppk.1	-						KIF14_uc010ppj.1_Intron	NM_014875	NP_055690			kinesin family member 14						microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			breast(3)|ovary(2)|skin(2)	7																		---	---	---	---
KIF21B	23046	broad.mit.edu	37	1	200978299	200978300	+	Intron	DEL	TA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:200978299_200978300delTA	uc001gvs.1	-						KIF21B_uc001gvr.1_Intron|KIF21B_uc009wzl.1_Intron|KIF21B_uc010ppn.1_Intron	NM_017596	NP_060066			kinesin family member 21B						microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6																		---	---	---	---
TIMM17A	10440	broad.mit.edu	37	1	201938497	201938497	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:201938497delT	uc001gxc.2	+							NM_006335	NP_006326			translocase of inner mitochondrial membrane 17						protein targeting to mitochondrion	integral to membrane|mitochondrial inner membrane presequence translocase complex	P-P-bond-hydrolysis-driven protein transmembrane transporter activity				0																		---	---	---	---
UBE2T	29089	broad.mit.edu	37	1	202300886	202300886	+	3'UTR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:202300886delA	uc001gxx.3	-	7						NM_014176	NP_054895			ubiquitin-conjugating enzyme E2T						DNA repair|protein K11-linked ubiquitination|protein K27-linked ubiquitination|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K6-linked ubiquitination|protein K63-linked ubiquitination	nucleoplasm	ATP binding|ubiquitin-protein ligase activity				0																		---	---	---	---
ELK4	2005	broad.mit.edu	37	1	205592607	205592607	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:205592607delT	uc001hcy.1	-						ELK4_uc001hcz.2_Intron	NM_001973	NP_001964			ELK4 protein isoform a							cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity				0	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)					T	SLC45A3	prostate								---	---	---	---
LGTN	1939	broad.mit.edu	37	1	206766800	206766803	+	Intron	DEL	GAGA	-	-	rs71570017		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:206766800_206766803delGAGA	uc001heh.2	-						LGTN_uc009xbw.2_Intron	NM_006893	NP_008824			ligatin						intracellular protein transport	cytoplasm	protein binding|receptor activity|translation initiation factor activity				0	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)															---	---	---	---
CR1L	1379	broad.mit.edu	37	1	207851488	207851488	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:207851488delA	uc001hga.3	+						CR1L_uc001hfz.2_Intron|CR1L_uc001hgb.1_Intron	NM_175710	NP_783641			complement component (3b/4b) receptor 1-like							cytoplasm|extracellular region|membrane					0																		---	---	---	---
CR1L	1379	broad.mit.edu	37	1	207890710	207890710	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:207890710delA	uc001hga.3	+						CR1L_uc001hfz.2_Intron|CR1L_uc001hgb.1_Intron	NM_175710	NP_783641			complement component (3b/4b) receptor 1-like							cytoplasm|extracellular region|membrane					0																		---	---	---	---
CD46	4179	broad.mit.edu	37	1	207933081	207933082	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:207933081_207933082insT	uc001hgc.2	+						CD46_uc001hgd.2_Intron|CD46_uc001hge.2_Intron|CD46_uc001hgf.2_Intron|CD46_uc001hgg.2_Intron|CD46_uc001hgh.2_Intron|CD46_uc001hgi.2_Intron|CD46_uc001hgj.2_Intron|CD46_uc001hgk.2_Intron|CD46_uc001hgl.2_Intron|CD46_uc001hgm.2_Intron|CD46_uc001hgn.2_Intron|CD46_uc001hgo.2_Intron|CD46_uc001hgp.2_Intron	NM_002389	NP_002380			CD46 antigen, complement regulatory protein						complement activation, classical pathway|innate immune response|interspecies interaction between organisms|single fertilization	inner acrosomal membrane|integral to plasma membrane	protein binding|receptor activity			large_intestine(2)|lung(1)|central_nervous_system(1)	4																		---	---	---	---
INTS7	25896	broad.mit.edu	37	1	212155942	212155942	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:212155942delA	uc001hiw.1	-						INTS7_uc009xdb.1_Intron|INTS7_uc001hix.1_Intron|INTS7_uc001hiy.1_Intron|INTS7_uc010pta.1_Intron	NM_015434	NP_056249			integrator complex subunit 7						snRNA processing	integrator complex	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)														---	---	---	---
NENF	29937	broad.mit.edu	37	1	212619002	212619002	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:212619002delC	uc001hjd.2	+						NENF_uc010ptf.1_Intron	NM_013349	NP_037481			neuron derived neurotrophic factor precursor							extracellular space	heme binding				0				all cancers(67;0.00967)|OV - Ovarian serous cystadenocarcinoma(81;0.0108)|GBM - Glioblastoma multiforme(131;0.0325)|Epithelial(68;0.132)														---	---	---	---
KCTD3	51133	broad.mit.edu	37	1	215759740	215759741	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:215759740_215759741insT	uc001hks.2	+						KCTD3_uc001hkt.2_Intron|KCTD3_uc010pub.1_Intron|KCTD3_uc009xdn.2_Intron	NM_016121	NP_057205			potassium channel tetramerisation domain							voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			ovary(3)	3				all cancers(67;0.0164)|OV - Ovarian serous cystadenocarcinoma(81;0.019)|GBM - Glioblastoma multiforme(131;0.0862)|Epithelial(68;0.13)														---	---	---	---
USH2A	7399	broad.mit.edu	37	1	215814143	215814144	+	Intron	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:215814143_215814144delAA	uc001hku.1	-							NM_206933	NP_996816			usherin isoform B						maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)											HNSCC(13;0.011)			---	---	---	---
Unknown	0	broad.mit.edu	37	1	219785370	219785370	+	IGR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:219785370delA								LYPLAL1 (399164 upstream) : SLC30A10 (73399 downstream)																																			---	---	---	---
EPRS	2058	broad.mit.edu	37	1	220207066	220207066	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:220207066delA	uc001hly.1	-						EPRS_uc010puf.1_Intron|EPRS_uc001hlz.1_Intron|EPRS_uc009xdt.1_Intron	NM_004446	NP_004437			glutamyl-prolyl tRNA synthetase						glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)													---	---	---	---
Unknown	0	broad.mit.edu	37	1	222435119	222435119	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:222435119delT								DUSP10 (519658 upstream) : HHIPL2 (260483 downstream)																																			---	---	---	---
DISP1	84976	broad.mit.edu	37	1	223165177	223165177	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:223165177delT	uc001hnu.1	+							NM_032890	NP_116279			dispatched A						diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)														---	---	---	---
DISP1	84976	broad.mit.edu	37	1	223168053	223168053	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:223168053delT	uc001hnu.1	+							NM_032890	NP_116279			dispatched A						diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)														---	---	---	---
TP53BP2	7159	broad.mit.edu	37	1	223972167	223972167	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:223972167delG	uc010pvb.1	-						TP53BP2_uc001hod.2_Intron|TP53BP2_uc010puz.1_Intron|TP53BP2_uc010pva.1_Intron	NM_001031685	NP_001026855			tumor protein p53 binding protein, 2 isoform 1						apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(2)|lung(1)	3				GBM - Glioblastoma multiforme(131;0.0958)														---	---	---	---
NVL	4931	broad.mit.edu	37	1	224499610	224499610	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:224499610delA	uc001hok.2	-						NVL_uc001hol.2_Intron|NVL_uc010pvd.1_Intron|NVL_uc010pve.1_Intron|NVL_uc010pvf.1_Intron	NM_002533	NP_002524			nuclear VCP-like isoform 1							aggresome|cytoplasm|nucleolus	ATP binding|nucleoside-triphosphatase activity			skin(2)	2				GBM - Glioblastoma multiforme(131;0.00501)														---	---	---	---
SRP9	6726	broad.mit.edu	37	1	225970839	225970839	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:225970839delT	uc001hpg.2	+						SRP9_uc001hpf.3_Intron|SRP9_uc001hph.2_Intron|SRP9_uc001hpi.3_Intron|SRP9_uc001hpj.1_Intron	NM_003133	NP_003124			signal recognition particle 9kDa isoform 2						negative regulation of translational elongation|SRP-dependent cotranslational protein targeting to membrane	cytosol|signal recognition particle receptor complex|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding|signal recognition particle binding				0																		---	---	---	---
LIN9	286826	broad.mit.edu	37	1	226438518	226438518	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:226438518delA	uc001hqa.2	-						LIN9_uc001hqb.2_Intron|LIN9_uc001hqc.2_Intron|LIN9_uc009xel.1_Intron	NM_173083	NP_775106			lin-9 homolog						cell cycle|DNA replication	nucleoplasm					0	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.131)														---	---	---	---
COG2	22796	broad.mit.edu	37	1	230828978	230828980	+	Intron	DEL	TTC	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:230828978_230828980delTTC	uc001htw.2	+						COG2_uc001htx.2_Intron|COG2_uc010pwc.1_Intron	NM_007357	NP_031383			component of oligomeric golgi complex 2 isoform						Golgi organization|intra-Golgi vesicle-mediated transport|intracellular protein transport|oligosaccharide biosynthetic process|protein glycosylation	Golgi membrane|Golgi stack|Golgi transport complex	protein binding|protein transporter activity				0	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)																---	---	---	---
DISC1	27185	broad.mit.edu	37	1	231931137	231931137	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:231931137delA	uc001huz.2	+						TSNAX-DISC1_uc010pwg.1_Intron|TSNAX-DISC1_uc010pwh.1_Intron|TSNAX-DISC1_uc010pwi.1_Intron|TSNAX-DISC1_uc010pwj.1_Intron|TSNAX-DISC1_uc010pwk.1_Intron|TSNAX-DISC1_uc010pwl.1_Intron|DISC1_uc010pwr.1_Intron|DISC1_uc010pws.1_Intron|DISC1_uc010pwt.1_Intron|DISC1_uc010pwu.1_Intron|DISC1_uc010pwv.1_Intron|DISC1_uc010pww.1_Intron|DISC1_uc010pwx.1_Intron|DISC1_uc010pwy.1_Intron|DISC1_uc010pwz.1_Intron|DISC1_uc010pxa.1_Intron|DISC1_uc001huy.2_Intron|DISC1_uc010pxb.1_Intron|DISC1_uc010pxc.1_Intron|DISC1_uc010pxd.1_Intron|DISC1_uc010pxe.1_Intron|DISC1_uc009xfr.2_Intron|DISC1_uc010pxf.1_Intron|DISC1_uc010pxg.1_Intron|DISC1_uc010pxh.1_Intron|DISC1_uc010pxi.1_Intron|DISC1_uc010pxj.1_Intron|DISC1_uc010pxk.1_Intron|DISC1_uc010pxl.1_Intron|DISC1_uc010pxm.1_Intron|DISC1_uc010pxn.1_Intron|DISC1_uc001hva.2_Intron	NM_018662	NP_061132			disrupted in schizophrenia 1 isoform L						microtubule cytoskeleton organization|neuron migration|positive regulation of neuroblast proliferation|positive regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	centrosome|microtubule	protein binding			skin(1)	1		all_cancers(173;0.0208)|Prostate(94;0.0975)																---	---	---	---
KCNK1	3775	broad.mit.edu	37	1	233806748	233806748	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:233806748delT	uc010pxo.1	+						KCNK1_uc001hvw.2_Intron|KCNK1_uc001hvx.2_Intron	NM_002245	NP_002236			potassium channel, subfamily K, member 1							voltage-gated potassium channel complex	inward rectifier potassium channel activity			central_nervous_system(1)	1		all_cancers(173;0.00217)|all_epithelial(177;0.121)|Prostate(94;0.122)|Acute lymphoblastic leukemia(190;0.175)			Ibutilide(DB00308)|Quinidine(DB00908)													---	---	---	---
KCNK1	3775	broad.mit.edu	37	1	233807425	233807425	+	3'UTR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:233807425delA	uc010pxo.1	+	3					KCNK1_uc001hvw.2_RNA|KCNK1_uc001hvx.2_RNA	NM_002245	NP_002236			potassium channel, subfamily K, member 1							voltage-gated potassium channel complex	inward rectifier potassium channel activity			central_nervous_system(1)	1		all_cancers(173;0.00217)|all_epithelial(177;0.121)|Prostate(94;0.122)|Acute lymphoblastic leukemia(190;0.175)			Ibutilide(DB00308)|Quinidine(DB00908)													---	---	---	---
ARID4B	51742	broad.mit.edu	37	1	235357134	235357134	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:235357134delA	uc001hwq.2	-						ARID4B_uc001hwr.2_Intron|ARID4B_uc001hws.3_Intron|ARID4B_uc001hwp.2_Intron|ARID4B_uc001hwt.3_Intron	NM_016374	NP_057458			AT rich interactive domain 4B isoform 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			ovary(2)|lung(1)	3	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)															---	---	---	---
LYST	1130	broad.mit.edu	37	1	235827365	235827365	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:235827365delA	uc001hxj.2	-						LYST_uc001hxi.2_Intron	NM_000081	NP_000072			lysosomal trafficking regulator						defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)											Chediak-Higashi_syndrome				---	---	---	---
NID1	4811	broad.mit.edu	37	1	236228100	236228100	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:236228100delC	uc001hxo.2	-						NID1_uc009xgd.2_Intron|uc001hxp.1_Frame_Shift_Del_p.P81fs	NM_002508	NP_002499			nidogen 1 precursor						cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)													---	---	---	---
GREM2	64388	broad.mit.edu	37	1	240656842	240656843	+	Intron	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:240656842_240656843delTT	uc001hys.2	-							NM_022469	NP_071914			gremlin 2 precursor						BMP signaling pathway	extracellular space	cytokine activity				0		all_cancers(173;0.0196)	OV - Ovarian serous cystadenocarcinoma(106;0.0123)															---	---	---	---
EXO1	9156	broad.mit.edu	37	1	242045337	242045337	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:242045337delT	uc001hzh.2	+						EXO1_uc001hzi.2_Intron|EXO1_uc001hzj.2_Intron|EXO1_uc009xgq.2_Intron	NM_130398	NP_569082			exonuclease 1 isoform b						meiosis|mismatch repair	nucleus	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|flap endonuclease activity|metal ion binding|protein binding|protein binding|ribonuclease H activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity			ovary(2)|lung(2)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;0.0555)	OV - Ovarian serous cystadenocarcinoma(106;0.0107)										Direct_reversal_of_damage|Editing_and_processing_nucleases					---	---	---	---
HNRNPU	3192	broad.mit.edu	37	1	245019932	245019932	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:245019932delA	uc001iaz.1	-						HNRNPU_uc001iaw.1_Intron|HNRNPU_uc001iax.1_Intron|HNRNPU_uc001iay.1_Intron|HNRNPU_uc001iba.1_Intron|HNRNPU_uc001ibb.1_Intron	NM_031844	NP_114032			heterogeneous nuclear ribonucleoprotein U						CRD-mediated mRNA stabilization	catalytic step 2 spliceosome|cell surface|CRD-mediated mRNA stability complex|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	ATP binding|DNA binding|protein binding|RNA binding				0	all_cancers(71;6.97e-06)|all_epithelial(71;0.000104)|all_neural(11;0.0269)|Breast(184;0.0545)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0989)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.00868)															---	---	---	---
TFB2M	64216	broad.mit.edu	37	1	246711788	246711789	+	Intron	DEL	AT	-	-	rs12087297	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:246711788_246711789delAT	uc001ibn.2	-							NM_022366	NP_071761			transcription factor B2, mitochondrial						positive regulation of transcription, DNA-dependent|transcription initiation from mitochondrial promoter	mitochondrial nucleoid	protein binding|rRNA (adenine-N6,N6-)-dimethyltransferase activity|transcription cofactor activity			ovary(1)	1	all_cancers(71;4.25e-05)|all_epithelial(71;4.92e-06)|Ovarian(71;0.0254)|all_lung(81;0.0272)|Breast(184;0.0318)|Lung NSC(105;0.0376)		OV - Ovarian serous cystadenocarcinoma(106;0.00358)															---	---	---	---
OR2L13	284521	broad.mit.edu	37	1	248262524	248262524	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:248262524delA	uc001ids.2	+							NM_175911	NP_787107			olfactory receptor, family 2, subfamily L,						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)															---	---	---	---
ZNF692	55657	broad.mit.edu	37	1	249150856	249150856	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:249150856delT	uc001ifc.1	-						ZNF692_uc001iez.1_5'Flank|ZNF692_uc001ifa.1_Intron|ZNF692_uc001ifb.1_Intron|ZNF692_uc001ifd.1_Intron|ZNF692_uc001ife.1_Intron|ZNF692_uc001iff.1_Intron|ZNF692_uc010pzr.1_Intron	NM_017865	NP_060335			zinc finger protein 692 isoform 2						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)															---	---	---	---
FAM150B	285016	broad.mit.edu	37	2	279919	279920	+	3'UTR	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:279919_279920delTT	uc002qwi.3	-	6						NM_001002919	NP_001002919			hypothetical protein LOC285016 precursor							extracellular region					0	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.00175)|Lung NSC(108;0.216)|all_epithelial(98;0.236)		all cancers(51;0.00091)|Epithelial(75;0.00656)|OV - Ovarian serous cystadenocarcinoma(76;0.00954)|GBM - Glioblastoma multiforme(21;0.128)														---	---	---	---
Unknown	0	broad.mit.edu	37	2	8743629	8743629	+	IGR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:8743629delA								LOC339788 (626652 upstream) : ID2 (75711 downstream)																																			---	---	---	---
ASAP2	8853	broad.mit.edu	37	2	9515236	9515242	+	Intron	DEL	AAAAAAA	-	-	rs112747713		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:9515236_9515242delAAAAAAA	uc002qzh.2	+						ASAP2_uc002qzi.2_Intron	NM_003887	NP_003878			ArfGAP with SH3 domain, ankyrin repeat and PH						regulation of ARF GTPase activity	Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|protein binding|zinc ion binding				0																		---	---	---	---
GRHL1	29841	broad.mit.edu	37	2	10101687	10101687	+	Intron	DEL	T	-	-	rs138724700		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:10101687delT	uc002raa.2	+						GRHL1_uc002rab.2_Intron|GRHL1_uc002rad.2_Intron|GRHL1_uc010yjb.1_Intron	NM_198182	NP_937825			grainyhead-like 1						cellular lipid metabolic process|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding			pancreas(1)|skin(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.246)														---	---	---	---
NOL10	79954	broad.mit.edu	37	2	10747254	10747254	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:10747254delA	uc002raq.2	-						NOL10_uc010yje.1_Intron|NOL10_uc010yjf.1_Intron|NOL10_uc002rap.2_Intron	NM_024894	NP_079170			nucleolar protein 10							nucleolus					0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.207)														---	---	---	---
TRIB2	28951	broad.mit.edu	37	2	12858399	12858399	+	5'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:12858399delT	uc002rbv.3	+	1					TRIB2_uc010yjp.1_Intron	NM_021643	NP_067675			tribbles homolog 2						negative regulation of fat cell differentiation|negative regulation of interleukin-10 biosynthetic process|negative regulation of protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of MAP kinase activity	cytoplasm|cytoskeleton|nucleus	ATP binding|protein kinase activity|protein kinase inhibitor activity|transcription factor binding|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			stomach(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)															OREG0014450	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
NBAS	51594	broad.mit.edu	37	2	15555630	15555630	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:15555630delA	uc002rcc.1	-						NBAS_uc010exl.1_Intron|NBAS_uc002rcd.1_Intron	NM_015909	NP_056993			neuroblastoma-amplified protein											ovary(2)|liver(1)|skin(1)	4																		---	---	---	---
SMC6	79677	broad.mit.edu	37	2	17851653	17851653	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:17851653delA	uc002rco.2	-						SMC6_uc010exo.2_Intron|SMC6_uc002rcn.2_Intron	NM_001142286	NP_001135758			SMC6 protein						DNA recombination|DNA repair	chromosome|nucleus	ATP binding			breast(4)|upper_aerodigestive_tract(1)|kidney(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)																	---	---	---	---
SMC6	79677	broad.mit.edu	37	2	17961872	17961872	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:17961872delT	uc010exo.2	-						GEN1_uc002rct.2_Intron|GEN1_uc010yjs.1_Intron|GEN1_uc002rcu.2_Intron	NM_024624	NP_078900			SMC6 protein						DNA recombination|DNA repair	chromosome|nucleus	ATP binding			breast(4)|upper_aerodigestive_tract(1)|kidney(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)																	---	---	---	---
PUM2	23369	broad.mit.edu	37	2	20451242	20451242	+	3'UTR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:20451242delA	uc002rds.1	-	20					PUM2_uc002rdq.1_3'UTR|PUM2_uc002rdt.1_3'UTR|PUM2_uc002rdr.2_3'UTR|PUM2_uc010yjy.1_3'UTR|PUM2_uc002rdu.1_3'UTR|PUM2_uc010yjz.1_3'UTR	NM_015317	NP_056132			pumilio homolog 2						regulation of translation	perinuclear region of cytoplasm|stress granule	protein binding|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
PUM2	23369	broad.mit.edu	37	2	20511470	20511470	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:20511470delA	uc002rds.1	-						PUM2_uc002rdt.1_Intron|PUM2_uc002rdr.2_Intron|PUM2_uc010yjy.1_Intron|PUM2_uc002rdu.1_Intron|PUM2_uc010yjz.1_Intron	NM_015317	NP_056132			pumilio homolog 2						regulation of translation	perinuclear region of cytoplasm|stress granule	protein binding|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
C2orf43	60526	broad.mit.edu	37	2	20939618	20939618	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:20939618delA	uc002rec.2	-						C2orf43_uc002rea.1_Intron|C2orf43_uc002reb.1_Intron|C2orf43_uc010yka.1_Intron|C2orf43_uc010ykb.1_Intron|C2orf43_uc010ykc.1_Intron|C2orf43_uc010ykd.1_Intron|C2orf43_uc010yke.1_Intron|C2orf43_uc010ykf.1_Intron	NM_021925	NP_068744			hypothetical protein LOC60526												0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
Unknown	0	broad.mit.edu	37	2	23621414	23621415	+	IGR	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:23621414_23621415insA								None (None upstream) : KLHL29 (134040 downstream)																																			---	---	---	---
ATAD2B	54454	broad.mit.edu	37	2	23977774	23977774	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:23977774delT	uc002rek.3	-						ATAD2B_uc010yki.1_Intron|ATAD2B_uc002rei.3_Intron|ATAD2B_uc002rej.3_Intron	NM_017552	NP_060022			ATPase family, AAA domain containing 2B								ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
DTNB	1838	broad.mit.edu	37	2	25642422	25642422	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:25642422delA	uc002rgh.2	-						DTNB_uc002rgg.2_Intron|DTNB_uc010yko.1_Intron|DTNB_uc010ykp.1_Intron|DTNB_uc002rgo.2_Intron|DTNB_uc002rgi.2_Intron|DTNB_uc002rgj.2_Intron|DTNB_uc002rgk.2_Intron|DTNB_uc002rgl.2_Intron|DTNB_uc002rgq.2_Intron|DTNB_uc002rgm.2_Intron|DTNB_uc002rgn.2_Intron|DTNB_uc002rgr.1_Intron|DTNB_uc002rgp.1_Intron	NM_021907	NP_068707			dystrobrevin, beta isoform 1							cytoplasm	calcium ion binding|zinc ion binding			large_intestine(2)|ovary(2)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
Unknown	0	broad.mit.edu	37	2	26363043	26363043	+	IGR	DEL	A	-	-	rs112696641		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:26363043delA								RAB10 (2721 upstream) : HADHA (50462 downstream)																																			---	---	---	---
HADHA	3030	broad.mit.edu	37	2	26423952	26423952	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:26423952delA	uc002rgy.2	-						HADHA_uc010yks.1_Intron	NM_000182	NP_000173			mitochondrial trifunctional protein, alpha						fatty acid beta-oxidation	fatty acid beta-oxidation multienzyme complex|mitochondrial nucleoid|nucleolus	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acetyltransferase activity|coenzyme binding|enoyl-CoA hydratase activity|long-chain-3-hydroxyacyl-CoA dehydrogenase activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				NADH(DB00157)													---	---	---	---
C2orf39	92749	broad.mit.edu	37	2	26654480	26654480	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:26654480delT	uc002rhg.2	+						C2orf39_uc010eym.1_Intron	NM_145038	NP_659475			hypothetical protein LOC92749												0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
CIB4	130106	broad.mit.edu	37	2	26863928	26863928	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:26863928delT	uc002rhm.2	-							NM_001029881	NP_001025052			calcium and integrin binding family member 4								calcium ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
C2orf18	54978	broad.mit.edu	37	2	26997841	26997841	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:26997841delA	uc002rhp.1	+						C2orf18_uc002rhq.1_Intron|C2orf18_uc010eyo.1_Intron|C2orf18_uc010ylc.1_Intron	NM_017877	NP_060347			ANT2-binding protein precursor							integral to membrane|lysosomal membrane					0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
AGBL5	60509	broad.mit.edu	37	2	27292719	27292719	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27292719delT	uc002rie.2	+						AGBL5_uc002rif.2_Intron	NM_021831	NP_068603			ATP/GTP binding protein-like 5 isoform 1						protein branching point deglutamylation|proteolysis	cytosol|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
PPM1G	5496	broad.mit.edu	37	2	27606807	27606807	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27606807delT	uc002rkl.2	-						PPM1G_uc002rkm.2_Intron	NM_002707	NP_002698			protein phosphatase 1G						cell cycle arrest|protein dephosphorylation	cytoplasm|nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
IFT172	26160	broad.mit.edu	37	2	27678580	27678580	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27678580delA	uc002rku.2	-						IFT172_uc010ezb.2_5'Flank	NM_015662	NP_056477			selective LIM binding factor homolog						cilium assembly	cilium	binding			large_intestine(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
SLC30A6	55676	broad.mit.edu	37	2	32400336	32400336	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:32400336delT	uc002roe.1	+						SLC30A6_uc002rof.1_Intron|SLC30A6_uc010ymw.1_Intron|SLC30A6_uc010ezr.1_Intron|SLC30A6_uc002rog.1_Intron|SLC30A6_uc010ezs.1_Intron|SLC30A6_uc002roh.1_Intron	NM_017964	NP_060434			solute carrier family 30 (zinc transporter),							Golgi membrane|integral to membrane	zinc ion transmembrane transporter activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)																	---	---	---	---
BIRC6	57448	broad.mit.edu	37	2	32666376	32666378	+	Intron	DEL	ATT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:32666376_32666378delATT	uc010ezu.2	+							NM_016252	NP_057336			baculoviral IAP repeat-containing 6						anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
BIRC6	57448	broad.mit.edu	37	2	32820253	32820253	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:32820253delT	uc010ezu.2	+							NM_016252	NP_057336			baculoviral IAP repeat-containing 6						anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
TTC27	55622	broad.mit.edu	37	2	33042664	33042664	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:33042664delA	uc002rom.2	+						TTC27_uc010ymx.1_Intron|TTC27_uc002ron.2_Intron	NM_017735	NP_060205			tetratricopeptide repeat domain 27								protein binding			central_nervous_system(1)	1																		---	---	---	---
LTBP1	4052	broad.mit.edu	37	2	33484825	33484825	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:33484825delA	uc002ros.2	+						LTBP1_uc002rot.2_Intron|LTBP1_uc002rou.2_Intron|LTBP1_uc002rov.2_Intron|LTBP1_uc010ymz.1_Intron|LTBP1_uc010yna.1_Intron	NM_206943	NP_996826			latent transforming growth factor beta binding						negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)																---	---	---	---
HEATR5B	54497	broad.mit.edu	37	2	37306514	37306514	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:37306514delT	uc002rpp.1	-							NM_019024	NP_061897			HEAT repeat containing 5B								binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)																---	---	---	---
C2orf56	55471	broad.mit.edu	37	2	37469699	37469699	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:37469699delT	uc002rqa.3	+						C2orf56_uc010ynj.1_Intron|C2orf56_uc002rqc.3_Intron|C2orf56_uc010ynk.1_Intron|C2orf56_uc010ynl.1_Intron|C2orf56_uc010fah.2_Intron	NM_144736	NP_653337			hypothetical protein LOC55471 isoform 1						mitochondrial respiratory chain complex I assembly	mitochondrion	enzyme binding|methyltransferase activity			central_nervous_system(1)	1		all_hematologic(82;0.21)																---	---	---	---
C2orf56	55471	broad.mit.edu	37	2	37469850	37469850	+	Intron	DEL	A	-	-	rs142499241	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:37469850delA	uc002rqa.3	+						C2orf56_uc010ynj.1_Intron|C2orf56_uc002rqc.3_Intron|C2orf56_uc010ynk.1_Intron|C2orf56_uc010ynl.1_Intron|C2orf56_uc010fah.2_Intron	NM_144736	NP_653337			hypothetical protein LOC55471 isoform 1						mitochondrial respiratory chain complex I assembly	mitochondrion	enzyme binding|methyltransferase activity			central_nervous_system(1)	1		all_hematologic(82;0.21)																---	---	---	---
CDC42EP3	10602	broad.mit.edu	37	2	37872789	37872789	+	3'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:37872789delT	uc002rqi.1	-	2						NM_006449	NP_006440			Cdc42 effector protein 3						regulation of cell shape|signal transduction	actin cytoskeleton|cytoplasm|endomembrane system|membrane	cytoskeletal regulatory protein binding				0		all_hematologic(82;0.172)																---	---	---	---
FAM82A1	151393	broad.mit.edu	37	2	38201322	38201323	+	Frame_Shift_Del	DEL	GA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:38201322_38201323delGA	uc002rql.2	+	3	715_716	c.592_593delGA	c.(592-594)GAGfs	p.E198fs	FAM82A1_uc002rqn.1_Frame_Shift_Del_p.E376fs|FAM82A1_uc002rqk.1_Frame_Shift_Del_p.E53fs|FAM82A1_uc002rqm.2_Frame_Shift_Del_p.E53fs	NM_144713	NP_653314	Q96LZ7	RMD2_HUMAN	family with sequence similarity 82, member A1	198						cytoplasm|integral to membrane|microtubule|spindle pole	binding			ovary(1)	1																		---	---	---	---
MAP4K3	8491	broad.mit.edu	37	2	39507284	39507284	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:39507284delA	uc002rro.2	-						MAP4K3_uc002rrp.2_Intron|MAP4K3_uc010yns.1_Intron	NM_003618	NP_003609			mitogen-activated protein kinase kinase kinase						JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(3)|lung(3)|stomach(1)|pancreas(1)	8		all_hematologic(82;0.211)																---	---	---	---
EML4	27436	broad.mit.edu	37	2	42515472	42515473	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:42515472_42515473insA	uc002rsi.2	+						EML4_uc010fap.2_Intron|EML4_uc002rsj.2_Intron	NM_019063	NP_061936			echinoderm microtubule associated protein like 4						microtubule-based process|mitosis	cytoplasm|microtubule	protein binding		EML4/ALK(246)	lung(246)|ovary(2)|central_nervous_system(1)|skin(1)	250								T	ALK	NSCLC								---	---	---	---
MTA3	57504	broad.mit.edu	37	2	42922775	42922782	+	Intron	DEL	AAAAAAAA	-	-	rs72441397		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:42922775_42922782delAAAAAAAA	uc002rso.1	+						MTA3_uc002rsp.1_Intron|MTA3_uc002rsq.2_Intron|MTA3_uc002rsr.2_Intron	NM_020744	NP_065795			metastasis associated 1 family, member 3							nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2																		---	---	---	---
THADA	63892	broad.mit.edu	37	2	43513973	43513973	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:43513973delT	uc002rsw.3	-						THADA_uc010far.2_Intron|THADA_uc002rsx.3_Intron|THADA_uc002rsy.3_Intron	NM_001083953	NP_001077422			thyroid adenoma associated								binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)																---	---	---	---
DYNC2LI1	51626	broad.mit.edu	37	2	44021481	44021481	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:44021481delT	uc002rtk.2	+						DYNC2LI1_uc002rth.2_Intron|DYNC2LI1_uc002rti.2_3'UTR|DYNC2LI1_uc002rtj.2_Intron|DYNC2LI1_uc002rtl.2_Intron|DYNC2LI1_uc010ynz.1_Intron	NM_016008	NP_057092			dynein 2 light intermediate chain isoform 1							apical part of cell|axonemal dynein complex|cilium axoneme|cytoplasm|microtubule|motile primary cilium	motor activity			ovary(1)	1		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)																---	---	---	---
LRPPRC	10128	broad.mit.edu	37	2	44139391	44139392	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:44139391_44139392insT	uc002rtr.2	-						LRPPRC_uc010yob.1_Intron	NM_133259	NP_573566			leucine-rich PPR motif-containing protein						mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			ovary(2)|skin(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)																---	---	---	---
PREPL	9581	broad.mit.edu	37	2	44555979	44555979	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:44555979delA	uc002ruf.2	-						PREPL_uc002rug.2_Intron|PREPL_uc002ruh.2_Intron|PREPL_uc010fax.2_Intron|PREPL_uc002rui.3_Intron|PREPL_uc002ruj.1_Intron|PREPL_uc002ruk.1_Intron	NM_006036	NP_006027			prolyl endopeptidase-like isoform C						proteolysis	cytosol	serine-type endopeptidase activity			ovary(1)	1		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)																---	---	---	---
Unknown	0	broad.mit.edu	37	2	47959043	47959054	+	IGR	DEL	AAAAAAAAAAAA	-	-	rs12992211		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:47959043_47959054delAAAAAAAAAAAA								MSH2 (52535 upstream) : MSH6 (51167 downstream)																																			---	---	---	---
MSH6	2956	broad.mit.edu	37	2	48025233	48025233	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:48025233delT	uc002rwd.3	+						MSH6_uc002rwc.2_Intron|MSH6_uc010fbj.2_Intron|MSH6_uc010yoi.1_Intron|MSH6_uc010yoj.1_Intron	NM_000179	NP_000170			mutS homolog 6						determination of adult lifespan|DNA damage response, signal transduction resulting in induction of apoptosis|isotype switching|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|response to UV|somatic hypermutation of immunoglobulin genes	MutSalpha complex	ATP binding|DNA-dependent ATPase activity|protein binding			large_intestine(53)|central_nervous_system(28)|endometrium(28)|stomach(22)|haematopoietic_and_lymphoid_tissue(9)|lung(7)|skin(6)|urinary_tract(5)|breast(5)|ovary(3)|thyroid(1)|upper_aerodigestive_tract(1)	168		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)					Mis|N|F|S		colorectal	colorectal|endometrial|ovarian		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				---	---	---	---
FOXN2	3344	broad.mit.edu	37	2	48601923	48601923	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:48601923delA	uc002rwh.1	+							NM_002158	NP_002149			T-cell leukemia virus enhancer factor						embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.0272)|LUSC - Lung squamous cell carcinoma(58;0.036)															---	---	---	---
FOXN2	3344	broad.mit.edu	37	2	48602092	48602092	+	Frame_Shift_Del	DEL	A	-	-	rs149269949		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:48602092delA	uc002rwh.1	+	7	1121	c.806delA	c.(805-807)CAAfs	p.Q269fs		NM_002158	NP_002149	P32314	FOXN2_HUMAN	T-cell leukemia virus enhancer factor	269					embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.0272)|LUSC - Lung squamous cell carcinoma(58;0.036)															---	---	---	---
ASB3	51130	broad.mit.edu	37	2	54041564	54041564	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:54041564delT	uc002rxi.3	-						ERLEC1_uc002rxl.2_Intron|ERLEC1_uc002rxm.2_Intron|ERLEC1_uc002rxn.2_Intron	NM_001164165	NP_001157637			hypothetical protein LOC100302652						intracellular signal transduction					ovary(1)|kidney(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)															---	---	---	---
PSME4	23198	broad.mit.edu	37	2	54114940	54114940	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:54114940delA	uc002rxp.2	-						PSME4_uc010yop.1_Intron|PSME4_uc010yoq.1_Intron|PSME4_uc010fbu.1_Intron|PSME4_uc010fbv.1_Intron|PSME4_uc010fbt.1_5'Flank	NM_014614	NP_055429			proteasome (prosome, macropain) activator						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			ovary(2)|breast(2)|pancreas(1)	5			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)															---	---	---	---
PSME4	23198	broad.mit.edu	37	2	54163841	54163841	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:54163841delG	uc002rxp.2	-						PSME4_uc010yop.1_Intron|PSME4_uc010yoq.1_Intron|PSME4_uc010fbu.1_Intron|PSME4_uc010fbv.1_Intron	NM_014614	NP_055429			proteasome (prosome, macropain) activator						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			ovary(2)|breast(2)|pancreas(1)	5			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)															---	---	---	---
Unknown	0	broad.mit.edu	37	2	58687298	58687298	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:58687298delT								FANCL (218783 upstream) : None (None downstream)																																			---	---	---	---
REL	5966	broad.mit.edu	37	2	61118739	61118739	+	Intron	DEL	A	-	-	rs10185028	byFrequency;by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:61118739delA	uc002sam.1	+						REL_uc002san.1_Intron	NM_002908	NP_002899			v-rel reticuloendotheliosis viral oncogene						positive regulation of I-kappaB kinase/NF-kappaB cascade	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3	all_hematologic(2;0.0797)	Ovarian(717;0.0728)	LUSC - Lung squamous cell carcinoma(5;6.2e-08)|Lung(5;1.65e-06)|Epithelial(17;0.064)|all cancers(80;0.221)					A		Hodgkin Lymphoma								---	---	---	---
KIAA1841	84542	broad.mit.edu	37	2	61336286	61336286	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:61336286delA	uc002saw.3	+						KIAA1841_uc002sax.3_Intron|KIAA1841_uc002say.2_Intron	NM_001129993	NP_001123465			KIAA1841 protein isoform a												0			Epithelial(17;0.193)															---	---	---	---
USP34	9736	broad.mit.edu	37	2	61510243	61510243	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:61510243delA	uc002sbe.2	-						USP34_uc002sbf.2_5'Flank	NM_014709	NP_055524			ubiquitin specific protease 34						positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)															---	---	---	---
XPO1	7514	broad.mit.edu	37	2	61729469	61729469	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:61729469delA	uc002sbj.2	-						XPO1_uc010fcl.2_Intron|XPO1_uc010ypn.1_Intron|XPO1_uc002sbk.2_Intron	NM_003400	NP_003391			exportin 1						intracellular protein transport|mitotic prometaphase|mRNA metabolic process|mRNA transport|viral genome transport in host cell|viral infectious cycle	annulate lamellae|Cajal body|cytosol|kinetochore|nuclear envelope|nucleolus|ribonucleoprotein complex	protein binding|protein transporter activity|RNA binding			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	4			LUSC - Lung squamous cell carcinoma(7;5.71e-05)|Epithelial(17;0.0662)|all cancers(80;0.226)															---	---	---	---
PELI1	57162	broad.mit.edu	37	2	64323400	64323401	+	Frame_Shift_Ins	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:64323400_64323401insA	uc002scs.3	-	5	4587_4588	c.548_549insT	c.(547-549)TTGfs	p.L183fs	PELI1_uc002sct.3_Frame_Shift_Ins_p.L183fs|PELI1_uc002scr.3_Frame_Shift_Ins_p.L4fs	NM_020651	NP_065702	Q96FA3	PELI1_HUMAN	pellino protein	183					innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol				ovary(1)	1																		---	---	---	---
PELI1	57162	broad.mit.edu	37	2	64327506	64327506	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:64327506delA	uc002scs.3	-						PELI1_uc002sct.3_Intron|PELI1_uc002scr.3_5'Flank	NM_020651	NP_065702			pellino protein						innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol				ovary(1)	1																		---	---	---	---
RAB1A	5861	broad.mit.edu	37	2	65316354	65316354	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:65316354delT	uc002sdm.2	-						RAB1A_uc002sdn.2_Intron|RAB1A_uc010yqe.1_Intron|RAB1A_uc002sdo.2_Intron	NM_004161	NP_004152			RAB1A, member RAS oncogene family isoform 1						protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	endoplasmic reticulum|Golgi apparatus	GTP binding|GTPase activity				0																		---	---	---	---
FBXO48	554251	broad.mit.edu	37	2	68691370	68691370	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:68691370delC	uc002seo.2	-	4	847	c.439delG	c.(439-441)GAAfs	p.E147fs		NM_001024680	NP_001019851	Q5FWF7	FBX48_HUMAN	F-box protein 48	147											0																		---	---	---	---
C2orf42	54980	broad.mit.edu	37	2	70403125	70403125	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:70403125delA	uc002sgh.2	-							NM_017880	NP_060350			hypothetical protein LOC54980												0																		---	---	---	---
MIR1285-2	100302268	broad.mit.edu	37	2	70480799	70480799	+	5'Flank	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:70480799delT	hsa-mir-1285-2|MI0006347	-																							0																		---	---	---	---
ZNF638	27332	broad.mit.edu	37	2	71626818	71626818	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:71626818delT	uc002shx.2	+						ZNF638_uc010yqw.1_Intron|ZNF638_uc002shy.2_Intron|ZNF638_uc002shz.2_Intron|ZNF638_uc002sia.2_Intron|ZNF638_uc002sib.1_Intron|ZNF638_uc010fed.2_Intron|ZNF638_uc002sic.2_Intron	NM_014497	NP_055312			zinc finger protein 638						RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4																		---	---	---	---
DYSF	8291	broad.mit.edu	37	2	71801279	71801279	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:71801279delC	uc002sie.2	+						DYSF_uc010feg.2_Intron|DYSF_uc010feh.2_Intron|DYSF_uc002sig.3_Intron|DYSF_uc010yqx.1_Intron|DYSF_uc010fee.2_Intron|DYSF_uc010fef.2_Intron|DYSF_uc010fei.2_Intron|DYSF_uc010fek.2_Intron|DYSF_uc010fej.2_Intron|DYSF_uc010fel.2_Intron|DYSF_uc010feo.2_Intron|DYSF_uc010fem.2_Intron|DYSF_uc010fen.2_Intron|DYSF_uc002sif.2_Intron|DYSF_uc010yqy.1_5'Flank	NM_003494	NP_003485			dysferlin isoform 8							cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7																		---	---	---	---
EXOC6B	23233	broad.mit.edu	37	2	72968233	72968233	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:72968233delA	uc010fep.2	-						EXOC6B_uc002sij.2_Intron	NM_015189	NP_056004			SEC15-like 2						protein transport|vesicle docking involved in exocytosis	exocyst				central_nervous_system(2)	2																		---	---	---	---
ALMS1	7840	broad.mit.edu	37	2	73827831	73827831	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:73827831delA	uc002sje.1	+	20	11809	c.11698delA	c.(11698-11700)AAAfs	p.K3900fs	ALMS1_uc002sjf.1_Frame_Shift_Del_p.K3856fs|ALMS1_uc002sjh.1_Frame_Shift_Del_p.K3286fs	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	3898					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9																		---	---	---	---
ALMS1	7840	broad.mit.edu	37	2	73836533	73836533	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:73836533delT	uc002sje.1	+						ALMS1_uc002sjf.1_Intron	NM_015120	NP_055935			Alstrom syndrome 1						G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9																		---	---	---	---
DUSP11	8446	broad.mit.edu	37	2	74000856	74000857	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:74000856_74000857insA	uc002sjp.2	-						DUSP11_uc002sjq.3_Intron	NM_003584	NP_003575			dual specificity phosphatase 11						RNA processing	nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity|RNA binding			skin(1)	1																		---	---	---	---
MOBKL1B	55233	broad.mit.edu	37	2	74394389	74394389	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:74394389delT	uc002skh.3	-						MOBKL1B_uc002ski.2_Intron	NM_018221	NP_060691			Mob4B protein						hippo signaling cascade		metal ion binding|protein binding				0																		---	---	---	---
RTKN	6242	broad.mit.edu	37	2	74654423	74654424	+	Intron	INS	-	AG	AG			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:74654423_74654424insAG	uc002sle.2	-						RTKN_uc002slc.2_Intron|RTKN_uc002sld.2_Intron	NM_001015055	NP_001015055			rhotekin isoform a						apoptosis|regulation of anti-apoptosis|Rho protein signal transduction	intracellular	GTP binding|GTP-Rho binding|GTPase inhibitor activity			skin(1)	1																		---	---	---	---
C2orf3	6936	broad.mit.edu	37	2	75917275	75917275	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:75917275delT	uc002sno.2	-						C2orf3_uc010ffs.2_Intron|C2orf3_uc002snn.2_Intron|C2orf3_uc010fft.2_Intron	NM_003203	NP_003194			hypothetical protein LOC6936						negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
SUCLG1	8802	broad.mit.edu	37	2	84676708	84676708	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:84676708delA	uc002son.2	-						SUCLG1_uc010ysk.1_Intron	NM_003849	NP_003840			succinate-CoA ligase, GDP-forming alpha subunit						tricarboxylic acid cycle		ATP citrate synthase activity|GTP binding|succinate-CoA ligase (GDP-forming) activity				0					Succinic acid(DB00139)													---	---	---	---
DNAH6	1768	broad.mit.edu	37	2	84811047	84811047	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:84811047delG	uc010fgb.2	+						DNAH6_uc002soo.2_Intron|DNAH6_uc002sop.2_Intron	NM_001370	NP_001361			dynein, axonemal, heavy polypeptide 6						microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			central_nervous_system(1)	1																		---	---	---	---
ELMOD3	84173	broad.mit.edu	37	2	85587802	85587802	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:85587802delT	uc002spf.3	+						ELMOD3_uc010fgg.2_Intron|ELMOD3_uc002spg.3_Intron|ELMOD3_uc002sph.3_Intron|ELMOD3_uc010ysn.1_Intron|ELMOD3_uc010yso.1_Intron|ELMOD3_uc010ysp.1_Intron	NM_001135021	NP_001128493			ELMO/CED-12 domain containing 3 isoform b						phagocytosis	cytoskeleton				ovary(2)	2																		---	---	---	---
MAT2A	4144	broad.mit.edu	37	2	85769177	85769177	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:85769177delA	uc002spr.2	+						MAT2A_uc010ysr.1_Intron|MAT2A_uc010fgk.2_Intron|MAT2A_uc010fgl.2_Intron|MAT2A_uc010fgm.1_3'UTR	NM_005911	NP_005902			methionine adenosyltransferase II, alpha						methylation|xenobiotic metabolic process	cytosol	ATP binding|metal ion binding|methionine adenosyltransferase activity				0					L-Methionine(DB00134)|S-Adenosylmethionine(DB00118)													---	---	---	---
PTCD3	55037	broad.mit.edu	37	2	86358372	86358372	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:86358372delT	uc002sqw.2	+						PTCD3_uc002sqx.1_Intron	NM_017952	NP_060422			pentatricopeptide repeat domain 3 precursor							mitochondrion	protein binding			ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	2	91685551	91685551	+	IGR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:91685551delA								None (None upstream) : LOC654342 (119641 downstream)																																			---	---	---	---
LOC654342	654342	broad.mit.edu	37	2	91843055	91843056	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:91843055_91843056insA	uc002sts.3	-						LOC654342_uc002stt.2_Intron|LOC654342_uc010yub.1_Intron					Homo sapiens cDNA clone IMAGE:4801360.												0																		---	---	---	---
ANKRD20B	729171	broad.mit.edu	37	2	95484478	95484478	+	5'Flank	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:95484478delA	uc010fhq.1	-						ANKRD20B_uc010fhp.2_Intron	NM_001012421	NP_001012421			ankyrin repeat domain 20 family, member A2												0																		---	---	---	---
MRPS5	64969	broad.mit.edu	37	2	95773809	95773810	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:95773809_95773810insT	uc002sub.2	-						MRPS5_uc002suc.2_Intron|MRPS5_uc010yud.1_Intron	NM_031902	NP_114108			mitochondrial ribosomal protein S5						translation	mitochondrion|ribosome	protein binding|RNA binding|structural constituent of ribosome			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
ANKRD23	200539	broad.mit.edu	37	2	97509550	97509550	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:97509550delA	uc002sxa.2	-						ANKRD23_uc002sxb.2_Intron|ANKRD23_uc002sxc.2_Intron	NM_144994	NP_659431			diabetes related ankyrin repeat protein							nucleus				ovary(1)	1																		---	---	---	---
TMEM131	23505	broad.mit.edu	37	2	98543876	98543876	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:98543876delA	uc002syh.3	-						TMEM131_uc010yvg.1_Intron|TMEM131_uc002syi.2_Frame_Shift_Del_p.*88fs	NM_015348	NP_056163			RW1 protein							integral to membrane				ovary(4)|central_nervous_system(2)	6																		---	---	---	---
EIF5B	9669	broad.mit.edu	37	2	99995647	99995647	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:99995647delA	uc002tab.2	+							NM_015904	NP_056988			eukaryotic translation initiation factor 5B						regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			ovary(2)|pancreas(1)	3																		---	---	---	---
Unknown	0	broad.mit.edu	37	2	101042568	101042568	+	IGR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:101042568delA								CHST10 (8477 upstream) : NMS (44376 downstream)																																			---	---	---	---
TBC1D8	11138	broad.mit.edu	37	2	101653935	101653936	+	Intron	INS	-	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:101653935_101653936insC	uc010fiv.2	-						TBC1D8_uc010yvw.1_Intron|TBC1D8_uc002tau.3_Intron	NM_001102426	NP_001095896			TBC1 domain family, member 8						blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			ovary(3)	3																		---	---	---	---
IL18RAP	8807	broad.mit.edu	37	2	103067258	103067258	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:103067258delA	uc002tbx.2	+						IL18RAP_uc010fiz.2_Intron	NM_003853	NP_003844			interleukin 18 receptor accessory protein						cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			skin(3)|ovary(2)	5																		---	---	---	---
Unknown	0	broad.mit.edu	37	2	106863863	106863863	+	IGR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:106863863delA								UXS1 (53068 upstream) : PLGLA (138906 downstream)																																			---	---	---	---
RANBP2	5903	broad.mit.edu	37	2	109345680	109345681	+	Intron	INS	-	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:109345680_109345681insC	uc002tem.3	+							NM_006267	NP_006258			RAN binding protein 2						carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18																		---	---	---	---
DPP10	57628	broad.mit.edu	37	2	116067054	116067054	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:116067054delA	uc002tla.1	+						DPP10_uc002tlb.1_Intron|DPP10_uc002tlc.1_Intron|DPP10_uc002tle.2_Intron|DPP10_uc002tlf.1_Intron	NM_020868	NP_065919			dipeptidyl peptidase 10 isoform long						proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10																		---	---	---	---
DPP10	57628	broad.mit.edu	37	2	116283455	116283455	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:116283455delT	uc002tla.1	+						DPP10_uc002tlb.1_Intron|DPP10_uc002tlc.1_Intron|DPP10_uc002tle.2_Intron|DPP10_uc002tlf.1_Intron	NM_020868	NP_065919			dipeptidyl peptidase 10 isoform long						proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10																		---	---	---	---
CNTNAP5	129684	broad.mit.edu	37	2	124783422	124783422	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:124783422delA	uc002tno.2	+						CNTNAP5_uc010flu.2_Intron	NM_130773	NP_570129			contactin associated protein-like 5 precursor						cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)														---	---	---	---
CNTNAP5	129684	broad.mit.edu	37	2	125285066	125285066	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:125285066delC	uc002tno.2	+						CNTNAP5_uc010flu.2_Intron	NM_130773	NP_570129			contactin associated protein-like 5 precursor						cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)														---	---	---	---
MAP3K2	10746	broad.mit.edu	37	2	128095443	128095443	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:128095443delT	uc002toj.1	-						MAP3K2_uc010flz.1_Intron	NM_006609	NP_006600			mitogen-activated protein kinase kinase kinase						activation of JUN kinase activity|cellular response to mechanical stimulus	nucleus	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein kinase binding			lung(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0706)														---	---	---	---
MAP3K2	10746	broad.mit.edu	37	2	128096511	128096511	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:128096511delT	uc002toj.1	-	2	185	c.120delA	c.(118-120)AAAfs	p.K40fs	MAP3K2_uc010flz.1_Frame_Shift_Del_p.K40fs	NM_006609	NP_006600	Q9Y2U5	M3K2_HUMAN	mitogen-activated protein kinase kinase kinase	40					activation of JUN kinase activity|cellular response to mechanical stimulus	nucleus	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein kinase binding			lung(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0706)														---	---	---	---
Unknown	0	broad.mit.edu	37	2	129098917	129098919	+	IGR	DEL	GTG	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:129098917_129098919delGTG								HS6ST1 (22746 upstream) : None (None downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	2	132383788	132383788	+	IGR	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:132383788delC								CCDC74A (92551 upstream) : C2orf27A (96276 downstream)																																			---	---	---	---
NCKAP5	344148	broad.mit.edu	37	2	133531631	133531631	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:133531631delT	uc002ttp.2	-						NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246			Nck-associated protein 5 isoform 1								protein binding				0																		---	---	---	---
CXCR4	7852	broad.mit.edu	37	2	136873550	136873550	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:136873550delT	uc002tuz.2	-						CXCR4_uc002tuy.2_5'UTR|CXCR4_uc010fnk.2_Intron	NM_003467	NP_003458			chemokine (C-X-C motif) receptor 4 isoform b						activation of MAPK activity|apoptosis|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|entry into host cell|inflammatory response|initiation of viral infection|regulation of chemotaxis|response to hypoxia|response to virus	cell leading edge|cell surface|cytoplasmic membrane-bounded vesicle|integral to membrane|plasma membrane	actin binding|C-X-C chemokine receptor activity|coreceptor activity|myosin light chain binding|ubiquitin binding|ubiquitin protein ligase binding			upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.155)	Framycetin(DB00452)													---	---	---	---
THSD7B	80731	broad.mit.edu	37	2	138033617	138033617	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:138033617delT	uc002tva.1	+						THSD7B_uc010zbj.1_Intron|THSD7B_uc002tvb.2_Intron	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)														---	---	---	---
THSD7B	80731	broad.mit.edu	37	2	138163483	138163484	+	Intron	DEL	CT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:138163483_138163484delCT	uc002tva.1	+						THSD7B_uc010zbj.1_Intron|THSD7B_uc002tvb.2_Intron	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)														---	---	---	---
THSD7B	80731	broad.mit.edu	37	2	138295915	138295915	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:138295915delA	uc002tva.1	+						THSD7B_uc010zbj.1_Intron	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)														---	---	---	---
LRP1B	53353	broad.mit.edu	37	2	141232977	141232977	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:141232977delT	uc002tvj.1	-							NM_018557	NP_061027			low density lipoprotein-related protein 1B						protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)											TSP Lung(27;0.18)			---	---	---	---
LRP1B	53353	broad.mit.edu	37	2	141474543	141474543	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:141474543delA	uc002tvj.1	-							NM_018557	NP_061027			low density lipoprotein-related protein 1B						protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)											TSP Lung(27;0.18)			---	---	---	---
LRP1B	53353	broad.mit.edu	37	2	141598364	141598364	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:141598364delT	uc002tvj.1	-							NM_018557	NP_061027			low density lipoprotein-related protein 1B						protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)											TSP Lung(27;0.18)			---	---	---	---
ACVR2A	92	broad.mit.edu	37	2	148680776	148680776	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:148680776delT	uc002twg.2	+						ACVR2A_uc010zbn.1_Intron|ACVR2A_uc002twh.2_Intron	NM_001616	NP_001607			activin A receptor, type IIA precursor						activin receptor signaling pathway|BMP signaling pathway|positive regulation of activin receptor signaling pathway|positive regulation of bone mineralization|positive regulation of erythrocyte differentiation|positive regulation of osteoblast differentiation|positive regulation of protein phosphorylation	cytoplasm|inhibin-betaglycan-ActRII complex|integral to plasma membrane	ATP binding|coreceptor activity|inhibin beta-A binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|transforming growth factor beta receptor activity			stomach(8)|large_intestine(2)|lung(1)|breast(1)|kidney(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.0969)														---	---	---	---
ACVR2A	92	broad.mit.edu	37	2	148683686	148683686	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:148683686delA	uc002twg.2	+	11	1572	c.1303delA	c.(1303-1305)AAAfs	p.K435fs	ACVR2A_uc010zbn.1_Frame_Shift_Del_p.K327fs|ACVR2A_uc002twh.2_Frame_Shift_Del_p.K435fs	NM_001616	NP_001607	P27037	AVR2A_HUMAN	activin A receptor, type IIA precursor	435	Cytoplasmic (Potential).|Protein kinase.				activin receptor signaling pathway|BMP signaling pathway|positive regulation of activin receptor signaling pathway|positive regulation of bone mineralization|positive regulation of erythrocyte differentiation|positive regulation of osteoblast differentiation|positive regulation of protein phosphorylation	cytoplasm|inhibin-betaglycan-ActRII complex|integral to plasma membrane	ATP binding|coreceptor activity|inhibin beta-A binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|transforming growth factor beta receptor activity			stomach(8)|large_intestine(2)|lung(1)|breast(1)|kidney(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.0969)														---	---	---	---
KIF5C	3800	broad.mit.edu	37	2	149861973	149861973	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:149861973delA	uc010zbu.1	+	22	2808	c.2440delA	c.(2440-2442)AAAfs	p.K814fs	KIF5C_uc002tws.1_RNA|KIF5C_uc002twu.1_Frame_Shift_Del_p.K96fs	NM_004522	NP_004513	O60282	KIF5C_HUMAN	kinesin family member 5C	814					microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.108)														---	---	---	---
Unknown	0	broad.mit.edu	37	2	152043190	152043190	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:152043190delT								RND3 (699010 upstream) : RBM43 (61539 downstream)																																			---	---	---	---
RIF1	55183	broad.mit.edu	37	2	152319553	152319553	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:152319553delA	uc002txm.2	+	30	3649	c.3519delA	c.(3517-3519)AGAfs	p.R1173fs	RIF1_uc002txl.2_Frame_Shift_Del_p.R1173fs|RIF1_uc002txn.2_Frame_Shift_Del_p.R1173fs|RIF1_uc002txo.2_Frame_Shift_Del_p.R1173fs|RIF1_uc002txp.2_RNA	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	1173					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)														---	---	---	---
NEB	4703	broad.mit.edu	37	2	152417500	152417500	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:152417500delA	uc010fnx.2	-						NEB_uc002txr.2_Intron	NM_004543	NP_004534			nebulin isoform 3						muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)														---	---	---	---
NEB	4703	broad.mit.edu	37	2	152423668	152423669	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:152423668_152423669insA	uc010fnx.2	-						NEB_uc002txr.2_Intron	NM_004543	NP_004534			nebulin isoform 3						muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)														---	---	---	---
NEB	4703	broad.mit.edu	37	2	152426974	152426974	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:152426974delA	uc010fnx.2	-						NEB_uc002txr.2_Intron	NM_004543	NP_004534			nebulin isoform 3						muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)														---	---	---	---
NEB	4703	broad.mit.edu	37	2	152492862	152492862	+	Intron	DEL	A	-	-	rs79875240	byFrequency;by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:152492862delA	uc010fnx.2	-						NEB_uc002txu.2_Intron	NM_004543	NP_004534			nebulin isoform 3						muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)														---	---	---	---
NEB	4703	broad.mit.edu	37	2	152523033	152523033	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:152523033delT	uc010fnx.2	-							NM_004543	NP_004534			nebulin isoform 3						muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)														---	---	---	---
NEB	4703	broad.mit.edu	37	2	152524209	152524209	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:152524209delT	uc010fnx.2	-							NM_004543	NP_004534			nebulin isoform 3						muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)														---	---	---	---
NEB	4703	broad.mit.edu	37	2	152589616	152589616	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:152589616delT	uc010fnx.2	-							NM_004543	NP_004534			nebulin isoform 3						muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)														---	---	---	---
CACNB4	785	broad.mit.edu	37	2	152709943	152709943	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:152709943delA	uc002tya.2	-						CACNB4_uc002txy.2_Intron|CACNB4_uc002txz.2_Intron|CACNB4_uc010fnz.2_Intron	NM_000726	NP_000717			calcium channel, voltage-dependent, beta 4						axon guidance|membrane depolarization|synaptic transmission	cytosol|internal side of plasma membrane|plasma membrane|synapse|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.156)	Verapamil(DB00661)													---	---	---	---
PRPF40A	55660	broad.mit.edu	37	2	153512706	153512706	+	3'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:153512706delT	uc002tyh.3	-	26					PRPF40A_uc002tyg.3_3'UTR	NM_017892	NP_060362			formin binding protein 3						mRNA processing|RNA splicing	nuclear matrix|nuclear speck	protein binding				0																		---	---	---	---
PRPF40A	55660	broad.mit.edu	37	2	153527901	153527901	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:153527901delA	uc002tyh.3	-						PRPF40A_uc002tyg.3_5'Flank|PRPF40A_uc010zcd.1_Intron	NM_017892	NP_060362			formin binding protein 3						mRNA processing|RNA splicing	nuclear matrix|nuclear speck	protein binding				0																		---	---	---	---
PRPF40A	55660	broad.mit.edu	37	2	153529199	153529199	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:153529199delA	uc002tyi.2	-						PRPF40A_uc002tyg.3_5'Flank|PRPF40A_uc002tyh.3_Intron|PRPF40A_uc010zcd.1_Intron|PRPF40A_uc002tyj.2_Intron	NM_017892	NP_060362			formin binding protein 3						mRNA processing|RNA splicing	nuclear matrix|nuclear speck	protein binding				0																		---	---	---	---
PRPF40A	55660	broad.mit.edu	37	2	153535752	153535752	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:153535752delA	uc002tyi.2	-						PRPF40A_uc002tyh.3_Intron|PRPF40A_uc010zcd.1_Intron|PRPF40A_uc002tyj.2_Intron|PRPF40A_uc002tyl.1_Intron	NM_017892	NP_060362			formin binding protein 3						mRNA processing|RNA splicing	nuclear matrix|nuclear speck	protein binding				0																		---	---	---	---
TANC1	85461	broad.mit.edu	37	2	159954483	159954483	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:159954483delT	uc002uag.2	+						TANC1_uc010fol.1_Intron|TANC1_uc010zcm.1_Intron|TANC1_uc010fom.1_Intron	NM_033394	NP_203752			tetratricopeptide repeat, ankyrin repeat and							cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
BAZ2B	29994	broad.mit.edu	37	2	160335070	160335070	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:160335070delA	uc002uao.2	-						BAZ2B_uc002uap.2_Intron|BAZ2B_uc002uas.1_Intron|BAZ2B_uc002uau.1_Intron|BAZ2B_uc002uat.3_Intron|BAZ2B_uc010fop.1_Intron	NM_013450	NP_038478			bromodomain adjacent to zinc finger domain, 2B						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4																		---	---	---	---
KCNH7	90134	broad.mit.edu	37	2	163292254	163292254	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:163292254delT	uc002uch.1	-						KCNH7_uc002uci.2_Intron	NM_033272	NP_150375			potassium voltage-gated channel, subfamily H,						regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)													---	---	---	---
COBLL1	22837	broad.mit.edu	37	2	165544246	165544246	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:165544246delC	uc010zcw.1	-						COBLL1_uc002ucp.2_Intron|COBLL1_uc002ucq.2_Intron|COBLL1_uc010zcx.1_Intron|COBLL1_uc002ucn.2_Intron|COBLL1_uc002uco.2_Intron	NM_014900	NP_055715			COBL-like 1											ovary(2)|pancreas(1)	3																		---	---	---	---
SCN3A	6328	broad.mit.edu	37	2	165997164	165997165	+	Frame_Shift_Ins	INS	-	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:165997164_165997165insG	uc002ucx.2	-	13	2507_2508	c.2015_2016insC	c.(2014-2016)CCAfs	p.P672fs	SCN3A_uc002ucy.2_Intron|SCN3A_uc002ucz.2_Intron|SCN3A_uc002uda.1_Intron|SCN3A_uc002udb.1_Intron	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	672						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)													---	---	---	---
SCN9A	6335	broad.mit.edu	37	2	167055359	167055359	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:167055359delT	uc010fpl.2	-	27	6098	c.5757delA	c.(5755-5757)AAAfs	p.K1919fs	uc002udp.2_Intron	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	1930						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)													---	---	---	---
DHRS9	10170	broad.mit.edu	37	2	169938083	169938083	+	5'UTR	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:169938083delG	uc002uep.2	+	5					DHRS9_uc002ueq.2_5'UTR|DHRS9_uc010zdc.1_Frame_Shift_Del_p.G58fs|DHRS9_uc002uer.1_5'UTR|DHRS9_uc010zdd.1_5'UTR|DHRS9_uc010zde.1_5'UTR	NM_005771	NP_005762			NADP-dependent retinol dehydrogenase/reductase						9-cis-retinoic acid biosynthetic process|androgen metabolic process|epithelial cell differentiation|progesterone metabolic process|retinol metabolic process	integral to endoplasmic reticulum membrane|microsome	alcohol dehydrogenase (NAD) activity|binding|racemase and epimerase activity|retinol dehydrogenase activity|testosterone dehydrogenase (NAD+) activity				0																		---	---	---	---
MYO3B	140469	broad.mit.edu	37	2	171458221	171458221	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:171458221delT	uc002ufy.2	+						MYO3B_uc002ufz.2_Intron|MYO3B_uc002ufw.2_Intron|MYO3B_uc002ufx.2_Intron|MYO3B_uc002ugb.2_Intron	NM_138995	NP_620482			myosin IIIB isoform 2						response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			lung(8)|ovary(6)|skin(4)|central_nervous_system(1)	19																		---	---	---	---
TLK1	9874	broad.mit.edu	37	2	171850598	171850598	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:171850598delA	uc002ugn.2	-						TLK1_uc002ugo.2_Intron|TLK1_uc002ugp.2_Intron|TLK1_uc010zdn.1_Intron	NM_012290	NP_036422			tousled-like kinase 1 isoform 1						cell cycle|chromatin modification|intracellular protein transport|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)	1																		---	---	---	---
TLK1	9874	broad.mit.edu	37	2	171853274	171853274	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:171853274delA	uc002ugn.2	-						TLK1_uc002ugo.2_Intron|TLK1_uc002ugp.2_Intron|TLK1_uc002ugq.2_Intron|TLK1_uc010zdn.1_Intron	NM_012290	NP_036422			tousled-like kinase 1 isoform 1						cell cycle|chromatin modification|intracellular protein transport|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)	1																		---	---	---	---
METTL8	79828	broad.mit.edu	37	2	172231362	172231362	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:172231362delT	uc010zdo.1	-						METTL8_uc002ugu.3_Intron|METTL8_uc002ugv.3_Intron|METTL8_uc002ugt.3_Intron|METTL8_uc002ugs.3_Intron|METTL8_uc010zdp.1_Intron	NM_024770	NP_079046			methyltransferase like 8								methyltransferase activity			ovary(1)	1																		---	---	---	---
DYNC1I2	1781	broad.mit.edu	37	2	172584624	172584625	+	Intron	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:172584624_172584625delTT	uc002uha.1	+						DYNC1I2_uc002uhc.2_Intron|DYNC1I2_uc002uhb.1_Intron|DYNC1I2_uc010zds.1_Intron|DYNC1I2_uc002uhe.1_Intron|DYNC1I2_uc002uhf.1_Intron|DYNC1I2_uc010zdt.1_Intron|DYNC1I2_uc002uhg.1_Intron|DYNC1I2_uc010zdu.1_Intron	NM_001378	NP_001369			dynein, cytoplasmic 1, intermediate chain 2						G2/M transition of mitotic cell cycle|interspecies interaction between organisms|microtubule-based movement|transport	centrosome|cytosol|dynein complex|microtubule|vesicle	microtubule motor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.198)															---	---	---	---
HAT1	8520	broad.mit.edu	37	2	172847964	172847964	+	Intron	DEL	A	-	-	rs78900975		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:172847964delA	uc002uhi.2	+						HAT1_uc002uhj.2_Intron	NM_003642	NP_003633			histone acetyltransferase 1						chromatin silencing at telomere|DNA packaging	cytoplasm|nuclear matrix|nucleoplasm	histone acetyltransferase activity|protein binding			large_intestine(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.216)															---	---	---	---
ITGA6	3655	broad.mit.edu	37	2	173337681	173337681	+	Intron	DEL	G	-	-	rs16860498	byFrequency;by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:173337681delG	uc002uhp.1	+						ITGA6_uc010fqk.1_Intron|ITGA6_uc010zdy.1_Intron|ITGA6_uc002uho.1_Intron|ITGA6_uc010fqm.1_5'Flank	NM_001079818	NP_001073286			integrin alpha chain, alpha 6 isoform a						blood coagulation|cell adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter	integrin complex	protein binding|receptor activity			ovary(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0979)															---	---	---	---
RAPGEF4	11069	broad.mit.edu	37	2	173662239	173662239	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:173662239delT	uc002uhv.3	+						RAPGEF4_uc002uhu.2_Intron|RAPGEF4_uc010fqn.2_Intron	NM_007023	NP_008954			Rap guanine nucleotide exchange factor (GEF) 4						blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.194)															---	---	---	---
RAPGEF4	11069	broad.mit.edu	37	2	173891538	173891538	+	Intron	DEL	T	-	-	rs75328884		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:173891538delT	uc002uhv.3	+						RAPGEF4_uc002uhw.3_Intron	NM_007023	NP_008954			Rap guanine nucleotide exchange factor (GEF) 4						blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.194)															---	---	---	---
OLA1	29789	broad.mit.edu	37	2	174946801	174946801	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:174946801delA	uc002uih.2	-						OLA1_uc002uii.2_Intron|OLA1_uc010fqq.2_Intron|OLA1_uc002uij.2_Intron|OLA1_uc002uik.2_Intron|OLA1_uc010fqr.2_Intron	NM_013341	NP_037473			Obg-like ATPase 1 isoform 1						ATP catabolic process	cytoplasm	ATP binding|GTP binding|hydrolase activity|protein binding			ovary(1)|breast(1)	2																		---	---	---	---
GPR155	151556	broad.mit.edu	37	2	175306646	175306647	+	Intron	DEL	TT	-	-	rs113036023		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:175306646_175306647delTT	uc002uit.2	-						GPR155_uc002uiu.2_Intron|GPR155_uc002uiv.2_Intron|GPR155_uc010fqs.2_Intron	NM_001033045	NP_001028217			G protein-coupled receptor 155 isoform 9						intracellular signal transduction|transmembrane transport	integral to membrane				ovary(1)	1																		---	---	---	---
OSBPL6	114880	broad.mit.edu	37	2	179258982	179258982	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179258982delT	uc002ulx.2	+						OSBPL6_uc002uly.2_Intron|OSBPL6_uc010zfe.1_Intron|OSBPL6_uc002ulz.2_Intron|OSBPL6_uc002uma.2_Intron	NM_032523	NP_115912			oxysterol-binding protein-like protein 6 isoform						lipid transport		lipid binding			pancreas(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.00578)|Epithelial(96;0.00847)|all cancers(119;0.0335)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179467331	179467331	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179467331delA	uc010zfg.1	-						uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron	NM_133378	NP_596869			titin isoform N2-A								ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179558767	179558767	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179558767delT	uc010zfg.1	-						TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron|TTN_uc010fre.1_Intron	NM_133378	NP_596869			titin isoform N2-A								ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
SESTD1	91404	broad.mit.edu	37	2	179986628	179986628	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179986628delT	uc002uni.3	-	13	1461	c.1311delA	c.(1309-1311)AAAfs	p.K437fs	SESTD1_uc002unh.3_5'UTR	NM_178123	NP_835224	Q86VW0	SESD1_HUMAN	SEC14 and spectrin domains 1	437	Spectrin 2.				regulation of calcium ion transport via voltage-gated calcium channel activity		phosphatidic acid binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding|protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0344)|Epithelial(96;0.0531)|all cancers(119;0.147)															---	---	---	---
ITGA4	3676	broad.mit.edu	37	2	182388861	182388861	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:182388861delT	uc002unu.2	+						ITGA4_uc010frj.1_Intron|ITGA4_uc002unv.2_Intron	NM_000885	NP_000876			integrin alpha 4 precursor						blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)													---	---	---	---
DNAJC10	54431	broad.mit.edu	37	2	183593883	183593884	+	Intron	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:183593883_183593884delTT	uc002uow.1	+						DNAJC10_uc002uox.1_Intron|DNAJC10_uc002uoy.1_Intron|DNAJC10_uc002uoz.1_Intron|DNAJC10_uc010fro.1_Intron	NM_018981	NP_061854			DnaJ (Hsp40) homolog, subfamily C, member 10						apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|ER-associated protein catabolic process|glycerol ether metabolic process|negative regulation of protein phosphorylation|protein folding|response to endoplasmic reticulum stress	endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|extracellular region	ATPase activator activity|ATPase binding|chaperone binding|electron carrier activity|heat shock protein binding|misfolded protein binding|protein disulfide oxidoreductase activity|unfolded protein binding			ovary(1)|large_intestine(1)|breast(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)															---	---	---	---
CALCRL	10203	broad.mit.edu	37	2	188224010	188224010	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:188224010delA	uc002upv.3	-						CALCRL_uc010frt.2_Intron	NM_005795	NP_005786			calcitonin receptor-like precursor							integral to plasma membrane				lung(3)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(96;0.227)															---	---	---	---
GULP1	51454	broad.mit.edu	37	2	189393930	189393930	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:189393930delT	uc010fru.2	+						GULP1_uc002uqc.3_Intron|GULP1_uc002uqd.2_Intron|GULP1_uc010zfw.1_Intron|GULP1_uc002uqe.2_Intron|GULP1_uc002uqf.2_Intron|GULP1_uc002uqg.2_Intron	NM_016315	NP_057399			GULP, engulfment adaptor PTB domain containing						apoptosis|lipid transport|phagocytosis, engulfment	cytoplasm|intracellular membrane-bounded organelle	signal transducer activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0423)|Epithelial(96;0.158)															---	---	---	---
DIRC1	116093	broad.mit.edu	37	2	189599261	189599261	+	3'UTR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:189599261delA	uc002uqi.1	-	2						NM_052952	NP_443184			disrupted in renal carcinoma 1												0			OV - Ovarian serous cystadenocarcinoma(117;0.00842)|Epithelial(96;0.102)															---	---	---	---
WDR75	84128	broad.mit.edu	37	2	190321968	190321968	+	Intron	DEL	A	-	-	rs77994114		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:190321968delA	uc002uql.1	+						WDR75_uc002uqm.1_Intron|WDR75_uc002uqn.1_Intron|WDR75_uc002uqo.1_5'Flank	NM_032168	NP_115544			WD repeat domain 75							nucleolus				ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.00105)|Epithelial(96;0.0129)|all cancers(119;0.0456)															---	---	---	---
GLS	2744	broad.mit.edu	37	2	191795353	191795353	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:191795353delT	uc002usf.2	+						GLS_uc002use.2_Intron|GLS_uc002usg.1_Intron|GLS_uc002ush.2_Intron|GLS_uc010zgi.1_Intron|GLS_uc010zgj.1_Intron	NM_014905	NP_055720			glutaminase precursor						cellular amino acid biosynthetic process|glutamate secretion|glutamine catabolic process|neurotransmitter secretion	mitochondrial matrix	glutaminase activity			ovary(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.00625)|Epithelial(96;0.0744)|all cancers(119;0.181)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)													---	---	---	---
STAT4	6775	broad.mit.edu	37	2	191940750	191940750	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:191940750delT	uc002usm.1	-						STAT4_uc002usn.1_Intron|STAT4_uc002uso.2_Intron	NM_003151	NP_003142			signal transducer and activator of transcription						JAK-STAT cascade	cytoplasm|nucleus	calcium ion binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(3)|skin(2)|lung(1)|ovary(1)|prostate(1)|pancreas(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.0864)|all cancers(119;0.204)															---	---	---	---
Unknown	0	broad.mit.edu	37	2	192746875	192746877	+	IGR	DEL	CTC	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:192746875_192746877delCTC								SDPR (34894 upstream) : TMEFF2 (67872 downstream)																																			---	---	---	---
SLC39A10	57181	broad.mit.edu	37	2	196583212	196583212	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:196583212delA	uc002utg.3	+						SLC39A10_uc002uth.3_Intron|SLC39A10_uc010zgp.1_Intron	NM_001127257	NP_001120729			solute carrier family 39 (zinc transporter),						zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			pancreas(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.221)															---	---	---	---
DNAH7	56171	broad.mit.edu	37	2	196602560	196602560	+	3'UTR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:196602560delA	uc002utj.3	-	65					DNAH7_uc002uti.3_3'UTR	NM_018897	NP_061720			dynein, axonemal, heavy chain 7						ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12																		---	---	---	---
CCDC150	284992	broad.mit.edu	37	2	197541991	197541991	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:197541991delT	uc002utp.1	+						CCDC150_uc010zgq.1_Intron|CCDC150_uc010zgr.1_Intron|CCDC150_uc010zgs.1_Intron	NM_001080539	NP_001074008			coiled-coil domain containing 150												0																		---	---	---	---
PGAP1	80055	broad.mit.edu	37	2	197755507	197755508	+	Intron	DEL	AC	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:197755507_197755508delAC	uc002utw.2	-						PGAP1_uc002utx.2_Intron|PGAP1_uc002uty.1_Intron|PGAP1_uc010zgv.1_Intron	NM_024989	NP_079265			GPI deacylase						attachment of GPI anchor to protein|C-terminal protein lipidation|intracellular protein transport|myo-inositol transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	nuclease activity|phosphoric ester hydrolase activity			ovary(3)|central_nervous_system(1)	4																		---	---	---	---
SF3B1	23451	broad.mit.edu	37	2	198281334	198281334	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:198281334delA	uc002uue.2	-							NM_012433	NP_036565			splicing factor 3b, subunit 1 isoform 1						nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)															---	---	---	---
SGOL2	151246	broad.mit.edu	37	2	201397676	201397676	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:201397676delT	uc002uvw.2	+						SGOL2_uc002uvv.3_Intron|SGOL2_uc010zhd.1_Intron|SGOL2_uc010zhe.1_Intron	NM_152524	NP_689737			shugoshin-like 2 isoform 1						cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			ovary(2)|skin(2)	4																		---	---	---	---
AOX1	316	broad.mit.edu	37	2	201469483	201469483	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:201469483delC	uc002uvx.2	+	9	835	c.734delC	c.(733-735)TCCfs	p.S245fs		NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	245	FAD-binding PCMH-type.				inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)													---	---	---	---
AOX1	316	broad.mit.edu	37	2	201477410	201477410	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:201477410delT	uc002uvx.2	+	14	1443	c.1342delT	c.(1342-1344)TTTfs	p.F448fs	AOX1_uc010zhf.1_Frame_Shift_Del_p.F4fs|AOX1_uc010fsu.2_5'UTR	NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	448					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)													---	---	---	---
ICA1L	130026	broad.mit.edu	37	2	203676526	203676526	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:203676526delA	uc002uzh.1	-						ICA1L_uc002uzi.1_Intron	NM_138468	NP_612477			islet cell autoantigen 1,69kDa-like isoform 1												0																		---	---	---	---
ABI2	10152	broad.mit.edu	37	2	204231587	204231587	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:204231587delT	uc002vaa.2	+						ABI2_uc010zig.1_Intron|ABI2_uc002uzz.2_Intron|ABI2_uc010zih.1_Intron|ABI2_uc010zii.1_Intron|ABI2_uc010zij.1_Intron|ABI2_uc002vab.2_5'Flank	NM_005759	NP_005750			abl interactor 2						actin polymerization or depolymerization|cell migration|peptidyl-tyrosine phosphorylation	cytoskeleton|cytosol|filopodium|lamellipodium	cytoskeletal adaptor activity|DNA binding|kinase binding|proline-rich region binding|SH3 domain binding|ubiquitin protein ligase binding				0																		---	---	---	---
NDUFS1	4719	broad.mit.edu	37	2	207009827	207009827	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:207009827delT	uc002vbe.2	-						NDUFS1_uc010ziq.1_Intron|NDUFS1_uc010zir.1_Intron|NDUFS1_uc010zis.1_Intron|NDUFS1_uc010zit.1_Intron|NDUFS1_uc010ziu.1_Intron	NM_005006	NP_004997			NADH dehydrogenase (ubiquinone) Fe-S protein 1,						apoptosis|ATP metabolic process|mitochondrial electron transport, NADH to ubiquinone|reactive oxygen species metabolic process|regulation of mitochondrial membrane potential|transport	mitochondrial intermembrane space|mitochondrial respiratory chain complex I	2 iron, 2 sulfur cluster binding|4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NADH dehydrogenase (ubiquinone) activity|protein binding			ovary(1)	1					NADH(DB00157)													---	---	---	---
CCNYL1	151195	broad.mit.edu	37	2	208591550	208591550	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:208591550delT	uc002vci.2	+						CCNYL1_uc002vch.2_Intron	NM_001142300	NP_001135772			cyclin Y-like 1 isoform 1						regulation of cyclin-dependent protein kinase activity		protein kinase binding				0				LUSC - Lung squamous cell carcinoma(261;0.0731)|Epithelial(149;0.139)|Lung(261;0.14)														---	---	---	---
PTH2R	5746	broad.mit.edu	37	2	209353918	209353918	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:209353918delT	uc002vdb.2	+						PTH2R_uc010zjb.1_Intron|PTH2R_uc010fuo.1_Intron	NM_005048	NP_005039			parathyroid hormone 2 receptor precursor							integral to plasma membrane	parathyroid hormone receptor activity			ovary(1)|breast(1)|skin(1)	3				Epithelial(149;0.0684)|Lung(261;0.0785)|LUSC - Lung squamous cell carcinoma(261;0.0836)														---	---	---	---
SMARCAL1	50485	broad.mit.edu	37	2	217297241	217297242	+	Intron	DEL	TC	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:217297241_217297242delTC	uc002vgc.3	+						SMARCAL1_uc010fvf.2_Intron|SMARCAL1_uc002vgd.3_Intron|SMARCAL1_uc010fvg.2_Intron	NM_014140	NP_054859			SWI/SNF-related matrix-associated						chromatin modification|DNA metabolic process|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity			ovary(3)|breast(3)|skin(1)	7		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)										Schimke_Immuno-Osseous_Dysplasia				---	---	---	---
RQCD1	9125	broad.mit.edu	37	2	219452151	219452151	+	Intron	DEL	T	-	-	rs139839364		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:219452151delT	uc010zkh.1	+						RQCD1_uc002vih.1_Intron|RQCD1_uc010zki.1_Intron	NM_005444	NP_005435			RCD1 required for cell differentiation1 homolog						nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|sex differentiation|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(1)|skin(1)	2		Renal(207;0.0915)		Epithelial(149;1.13e-06)|all cancers(144;0.000192)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)														---	---	---	---
PRKAG3	53632	broad.mit.edu	37	2	219689199	219689199	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:219689199delC	uc002vjb.1	-							NM_017431	NP_059127			AMP-activated protein kinase, non-catalytic						cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|intracellular protein kinase cascade|regulation of fatty acid oxidation	cytosol	AMP-activated protein kinase activity|protein kinase binding			ovary(1)|lung(1)	2		Renal(207;0.0474)		Epithelial(149;4.35e-07)|all cancers(144;8.96e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)														---	---	---	---
SLC23A3	151295	broad.mit.edu	37	2	220034745	220034746	+	5'UTR	DEL	CA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:220034745_220034746delCA	uc010zks.1	-	1					NHEJ1_uc002vjq.3_RNA|SLC23A3_uc010zkr.1_5'UTR|SLC23A3_uc010fwb.2_5'UTR|SLC23A3_uc002vjs.1_5'Flank|SLC23A3_uc002vjt.1_5'Flank	NM_001144889	NP_001138361			solute carrier family 23 (nucleobase						transmembrane transport	integral to membrane	protein binding|transporter activity				0		Renal(207;0.0474)		Epithelial(149;9.27e-07)|all cancers(144;0.000156)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)														---	---	---	---
PAX3	5077	broad.mit.edu	37	2	223066912	223066912	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:223066912delA	uc010fwo.2	-						PAX3_uc002vmt.1_Intron|PAX3_uc002vmy.1_Intron|PAX3_uc002vmv.1_Intron|PAX3_uc002vmw.1_Intron|PAX3_uc002vmx.1_Intron	NM_181457	NP_852122			paired box 3 isoform PAX3						apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX3/FOXO1(749)|PAX3/NCOA1(8)|PAX3/NCOA2(4)	soft_tissue(761)|ovary(4)|skin(1)	766		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)				T	FOXO1A|NCOA1	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome						---	---	---	---
FARSB	10056	broad.mit.edu	37	2	223488453	223488453	+	Intron	DEL	A	-	-	rs111567015	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:223488453delA	uc002vne.1	-						FARSB_uc010zlq.1_Intron|FARSB_uc002vnf.1_Intron	NM_005687	NP_005678			phenylalanyl-tRNA synthetase, beta subunit						phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|RNA binding			ovary(1)	1		Renal(207;0.0183)		Epithelial(121;3.47e-10)|all cancers(144;1.86e-07)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.011)	L-Phenylalanine(DB00120)													---	---	---	---
FARSB	10056	broad.mit.edu	37	2	223505480	223505480	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:223505480delA	uc002vne.1	-						FARSB_uc010zlq.1_Intron|FARSB_uc002vnf.1_Intron	NM_005687	NP_005678			phenylalanyl-tRNA synthetase, beta subunit						phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|RNA binding			ovary(1)	1		Renal(207;0.0183)		Epithelial(121;3.47e-10)|all cancers(144;1.86e-07)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.011)	L-Phenylalanine(DB00120)													---	---	---	---
DOCK10	55619	broad.mit.edu	37	2	225664836	225664836	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:225664836delT	uc010fwz.1	-						DOCK10_uc002vob.2_Intron|DOCK10_uc002voa.2_Intron|DOCK10_uc002voc.2_Intron	NM_014689	NP_055504			dedicator of cytokinesis 10								GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)														---	---	---	---
COL4A3	1285	broad.mit.edu	37	2	228159417	228159417	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:228159417delA	uc002vom.1	+						COL4A3_uc002von.1_Intron|COL4A3_uc002voo.1_Intron|COL4A3_uc002vop.1_Intron|uc002voq.1_Intron|uc002vor.1_Intron	NM_000091	NP_000082			alpha 3 type IV collagen isoform 1 precursor						activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)														---	---	---	---
SPHKAP	80309	broad.mit.edu	37	2	228880881	228880881	+	Intron	DEL	T	-	-	rs113826244		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:228880881delT	uc002vpq.2	-						SPHKAP_uc002vpp.2_Intron|SPHKAP_uc010zlx.1_Intron	NM_001142644	NP_001136116			sphingosine kinase type 1-interacting protein							cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)														---	---	---	---
TRIP12	9320	broad.mit.edu	37	2	230634174	230634174	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:230634174delA	uc002vpw.1	-						TRIP12_uc002vpx.1_Intron|TRIP12_uc002vpy.1_Intron	NM_004238	NP_004229			thyroid hormone receptor interactor 12						protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)														---	---	---	---
TRIP12	9320	broad.mit.edu	37	2	230639110	230639110	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:230639110delT	uc002vpw.1	-						TRIP12_uc002vpx.1_Intron|TRIP12_uc002vpy.1_Intron	NM_004238	NP_004229			thyroid hormone receptor interactor 12						protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)														---	---	---	---
TRIP12	9320	broad.mit.edu	37	2	230679966	230679966	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:230679966delA	uc002vpw.1	-						TRIP12_uc002vpx.1_Intron|TRIP12_uc002vpy.1_Intron|TRIP12_uc010zlz.1_Intron|TRIP12_uc010fxh.1_Intron	NM_004238	NP_004229			thyroid hormone receptor interactor 12						protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)														---	---	---	---
SP140	11262	broad.mit.edu	37	2	231112389	231112389	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:231112389delT	uc002vql.2	+						SP140_uc010zma.1_Intron|SP140_uc002vqk.2_Intron|SP140_uc002vqn.2_Intron|SP140_uc002vqm.2_Intron|SP140_uc010fxl.2_Intron	NM_007237	NP_009168			SP140 nuclear body protein isoform 1						defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)														---	---	---	---
HTR2B	3357	broad.mit.edu	37	2	231988611	231988611	+	5'UTR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:231988611delA	uc002vro.2	-	2					PSMD1_uc002vrm.1_Intron|PSMD1_uc010fxu.1_Intron|PSMD1_uc002vrn.1_Intron|HTR2B_uc010fxv.2_5'UTR	NM_000867	NP_000858			5-hydroxytryptamine (serotonin) receptor 2B						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cardiac muscle hypertrophy|cellular response to calcium ion|cellular response to temperature stimulus|cGMP biosynthetic process|embryonic morphogenesis|ERK1 and ERK2 cascade|G-protein coupled receptor internalization|heart morphogenesis|intestine smooth muscle contraction|negative regulation of apoptosis|negative regulation of autophagy|neural crest cell migration|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|phosphorylation|positive regulation of cell division|positive regulation of cytokine production|positive regulation of cytokine secretion|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAP kinase activity|positive regulation of nitric-oxide synthase activity|protein kinase C signaling cascade|regulation of behavior|release of sequestered calcium ion into cytosol|response to drug|vasoconstriction	cytoplasm|integral to membrane|plasma membrane	calcium channel activity|drug binding|G-protein alpha-subunit binding|phosphatidylinositol phospholipase C activity|Ras GTPase activator activity|serotonin binding|serotonin receptor activity				0		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)|Medulloblastoma(418;0.232)		Epithelial(121;4.48e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0141)	Chlorprothixene(DB01239)|Eletriptan(DB00216)|Fenfluramine(DB00574)|Methotrimeprazine(DB01403)|Minaprine(DB00805)|Quetiapine(DB01224)|Sumatriptan(DB00669)|Tegaserod(DB01079)|Triflupromazine(DB00508)													---	---	---	---
GIGYF2	26058	broad.mit.edu	37	2	233660685	233660685	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:233660685delA	uc002vti.3	+						GIGYF2_uc010zmj.1_Intron|GIGYF2_uc002vtg.2_Intron|GIGYF2_uc002vtj.3_Intron|GIGYF2_uc002vtk.3_Intron|GIGYF2_uc002vth.3_Intron|GIGYF2_uc010zmk.1_Intron|GIGYF2_uc010zml.1_Intron	NM_015575	NP_056390			GRB10 interacting GYF protein 2 isoform b						cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)														---	---	---	---
DGKD	8527	broad.mit.edu	37	2	234359865	234359873	+	Intron	DEL	TTAAAAACA	-	-	rs78850147	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:234359865_234359873delTTAAAAACA	uc002vui.1	+						DGKD_uc002vuj.1_Intron|DGKD_uc010fyh.1_Intron|DGKD_uc010fyi.1_Intron	NM_152879	NP_690618			diacylglycerol kinase, delta 130kDa isoform 2						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|pancreas(1)|lung(1)|skin(1)	5		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)													---	---	---	---
UGT1A5	54579	broad.mit.edu	37	2	234656369	234656369	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:234656369delT	uc002vuw.2	+						UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Intron|UGT1A3_uc002vuy.2_Intron|UGT1A9_uc002vva.2_5'Flank	NM_019078	NP_061951			UDP glycosyltransferase 1 family, polypeptide A5						xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;4.51e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000523)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.00645)														---	---	---	---
COL6A3	1293	broad.mit.edu	37	2	238287016	238287016	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:238287016delA	uc002vwl.2	-						COL6A3_uc002vwo.2_Intron|COL6A3_uc010znj.1_Intron|COL6A3_uc002vwq.2_Intron|COL6A3_uc002vwr.2_Intron|COL6A3_uc010znk.1_Intron	NM_004369	NP_004360			alpha 3 type VI collagen isoform 1 precursor						axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)														---	---	---	---
PER2	8864	broad.mit.edu	37	2	239168597	239168597	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:239168597delT	uc002vyc.2	-						PER2_uc010znv.1_Intron	NM_022817	NP_073728			period 2						circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			upper_aerodigestive_tract(1)|breast(1)	2		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)														---	---	---	---
PER2	8864	broad.mit.edu	37	2	239181576	239181576	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:239181576delT	uc002vyc.2	-						PER2_uc010znv.1_Intron|PER2_uc010znw.1_Intron|PER2_uc010fyx.1_Intron	NM_022817	NP_073728			period 2						circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			upper_aerodigestive_tract(1)|breast(1)	2		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)														---	---	---	---
PRR21	643905	broad.mit.edu	37	2	240982117	240982144	+	Frame_Shift_Del	DEL	GTGGGTGAAGAGGCATGGATGAAGGACT	-	-	rs147066740	byFrequency;by1000genomes;byFrequency;byFrequency;by1000genomes;byFrequency;by1000genomes;byFrequency;by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:240982117_240982144delGTGGGTGAAGAGGCATGGATGAAGGACT	uc010zod.1	-	1	256_283	c.256_283delAGTCCTTCATCCATGCCTCTTCACCCAC	c.(256-285)AGTCCTTCATCCATGCCTCTTCACCCACGGfs	p.S86fs		NM_001080835	NP_001074304	Q8WXC7	PRR21_HUMAN	proline rich 21	86_95	Pro-rich.									ovary(1)|skin(1)	2																		---	---	---	---
GPR35	2859	broad.mit.edu	37	2	241556159	241556166	+	Intron	DEL	AAAAAAAA	-	-	rs67521970		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:241556159_241556166delAAAAAAAA	uc010fzh.1	+						GPR35_uc010fzi.1_Intron|CAPN10_uc002vzq.1_Intron	NM_005301	NP_005292			G protein-coupled receptor 35							integral to plasma membrane	G-protein coupled receptor activity			skin(2)|pancreas(1)	3		all_epithelial(40;7.49e-12)|Breast(86;0.000148)|Renal(207;0.00571)|Ovarian(221;0.104)|all_neural(83;0.107)|all_hematologic(139;0.182)|all_lung(227;0.186)|Melanoma(123;0.238)		Epithelial(32;5.29e-32)|all cancers(36;1.38e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.02e-06)|Lung(119;0.00163)|Colorectal(34;0.00463)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.031)														---	---	---	---
Unknown	0	broad.mit.edu	37	2	242523790	242523790	+	IGR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:242523790delA								BOK (10239 upstream) : THAP4 (31 downstream)																																			---	---	---	---
D2HGDH	728294	broad.mit.edu	37	2	242680356	242680356	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:242680356delA	uc002wce.1	+						D2HGDH_uc010zpc.1_Intron|D2HGDH_uc010fzq.1_Intron|D2HGDH_uc002wcg.1_Intron	NM_152783	NP_689996			D-2-hydroxyglutarate dehydrogenase precursor						2-oxoglutarate metabolic process|cellular protein metabolic process|response to cobalt ion|response to manganese ion|response to zinc ion	mitochondrial matrix	(R)-2-hydroxyglutarate dehydrogenase activity|flavin adenine dinucleotide binding|protein binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)														---	---	---	---
ARL8B	55207	broad.mit.edu	37	3	5212424	5212424	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:5212424delT	uc003bqg.2	+						ARL8B_uc011asx.1_Intron|ARL8B_uc011asy.1_Intron	NM_018184	NP_060654			ADP-ribosylation factor-like 10C						cell cycle|cell division|chromosome segregation|small GTPase mediated signal transduction	late endosome membrane|lysosomal membrane|midbody|spindle midzone	alpha-tubulin binding|beta-tubulin binding|GDP binding|GTP binding|GTPase activity				0				OV - Ovarian serous cystadenocarcinoma(96;0.0717)|Epithelial(13;0.0777)														---	---	---	---
GRM7	2917	broad.mit.edu	37	3	7456626	7456626	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:7456626delA	uc003bqm.2	+						GRM7_uc011ata.1_Intron|GRM7_uc011atb.1_Intron|GRM7_uc010hcf.2_Intron|GRM7_uc011atc.1_Intron|GRM7_uc010hcg.2_Intron|GRM7_uc003bql.2_Intron|GRM7_uc003bqn.1_Intron	NM_000844	NP_000835			glutamate receptor, metabotropic 7 isoform a						negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)													---	---	---	---
THUMPD3	25917	broad.mit.edu	37	3	9425697	9425697	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:9425697delA	uc003bro.3	+						LOC440944_uc003brm.2_Intron|THUMPD3_uc003brn.3_Intron	NM_001114092	NP_001107564			THUMP domain containing 3								methyltransferase activity|protein binding|RNA binding			ovary(1)	1	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.101)														---	---	---	---
CPNE9	151835	broad.mit.edu	37	3	9745863	9745863	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:9745863delA	uc003bsd.2	+							NM_153635	NP_705899			copine-like protein											ovary(2)	2	Medulloblastoma(99;0.227)																	---	---	---	---
BRPF1	7862	broad.mit.edu	37	3	9785886	9785888	+	Intron	DEL	CTT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:9785886_9785888delCTT	uc003bse.2	+						BRPF1_uc003bsf.2_Intron|BRPF1_uc003bsg.2_Intron|BRPF1_uc011ati.1_Intron	NM_004634	NP_004625			bromodomain and PHD finger-containing protein 1						histone H3 acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|MOZ/MORF histone acetyltransferase complex|plasma membrane	DNA binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Medulloblastoma(99;0.227)																	---	---	---	---
OGG1	4968	broad.mit.edu	37	3	9797996	9797996	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:9797996delA	uc003bsi.2	+						OGG1_uc003bsh.2_Intron|OGG1_uc003bsj.2_Intron|OGG1_uc003bsk.2_Intron|OGG1_uc003bsl.2_Intron|OGG1_uc003bsm.2_Intron|OGG1_uc003bsn.2_Intron|OGG1_uc003bso.2_Intron|OGG1_uc003bsp.1_Intron|OGG1_uc010hcm.1_Intron|OGG1_uc003bsq.1_Intron|OGG1_uc003bsr.1_Intron	NM_002542	NP_002533			8-oxoguanine DNA-glycosylase 1 isoform 1a						depurination|nucleotide-excision repair|regulation of protein import into nucleus, translocation|regulation of transcription, DNA-dependent|response to oxidative stress|response to radiation	mitochondrion|nuclear matrix|nuclear speck	damaged DNA binding|endonuclease activity|oxidized purine base lesion DNA N-glycosylase activity|protein binding				0	Medulloblastoma(99;0.227)												BER_DNA_glycosylases					---	---	---	---
TTLL3	26140	broad.mit.edu	37	3	9842117	9842117	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:9842117delT	uc003btd.3	+						ARPC4_uc003bsz.1_Intron|ARPC4_uc003bta.1_Intron|ARPC4_uc003btb.1_Intron|ARPC4_uc003btc.1_Intron					RecName: Full=Tubulin--tyrosine ligase-like protein 3; AltName: Full=HOTTL;						axoneme assembly|cilium assembly|protein polyglycylation	cilium axoneme|cytoplasm|microtubule	protein-glycine ligase activity, initiating|tubulin-tyrosine ligase activity			large_intestine(2)	2	Medulloblastoma(99;0.227)																	---	---	---	---
IL17RE	132014	broad.mit.edu	37	3	9953492	9953492	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:9953492delT	uc003btu.2	+						CIDEC_uc003bto.2_Intron|IL17RE_uc003btw.2_Intron|IL17RE_uc003btx.2_Intron|IL17RE_uc010hcq.2_Intron|IL17RE_uc003bty.2_Intron	NM_153483	NP_705616			interleukin 17 receptor E isoform 1							cytoplasm|extracellular region|integral to membrane	receptor activity			central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(96;5.34e-64)														---	---	---	---
PRRT3	285368	broad.mit.edu	37	3	9991859	9991859	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:9991859delA	uc003bul.2	-						CIDEC_uc003bto.2_Intron|PRRT3_uc003buk.2_Intron|PRRT3_uc003bum.2_Intron	NM_207351	NP_997234			proline-rich transmembrane protein 3 precursor							integral to membrane					0																		---	---	---	---
TMEM40	55287	broad.mit.edu	37	3	12791467	12791467	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:12791467delA	uc003bxg.1	-						TMEM40_uc003bxh.1_Intron|TMEM40_uc003bxi.1_Intron|TMEM40_uc011auv.1_Intron	NM_018306	NP_060776			transmembrane protein 40							integral to membrane					0																		---	---	---	---
TMEM43	79188	broad.mit.edu	37	3	14183281	14183281	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:14183281delA	uc003byk.2	+	12	1443	c.1189delA	c.(1189-1191)AAAfs	p.K397fs		NM_024334	NP_077310	Q9BTV4	TMM43_HUMAN	transmembrane protein 43	397	Nuclear (Potential).					endoplasmic reticulum|Golgi apparatus|integral to membrane|nuclear inner membrane				ovary(1)	1																		---	---	---	---
LSM3	27258	broad.mit.edu	37	3	14239433	14239433	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:14239433delT	uc003byn.2	+						uc003byo.1_5'Flank	NM_014463	NP_055278			Lsm3 protein						exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	catalytic step 2 spliceosome|cytosol	protein binding|RNA binding			ovary(1)	1																		---	---	---	---
ZFYVE20	64145	broad.mit.edu	37	3	15122530	15122530	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:15122530delT	uc003bzm.1	-						ZFYVE20_uc010hek.1_Intron|ZFYVE20_uc011avn.1_Intron	NM_022340	NP_071735			FYVE-finger-containing Rab5 effector protein						blood coagulation|endosome transport|protein transport	early endosome membrane|plasma membrane	protein binding|zinc ion binding			skin(2)	2																		---	---	---	---
KCNH8	131096	broad.mit.edu	37	3	19246134	19246134	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:19246134delA	uc003cbk.1	+						KCNH8_uc011awe.1_Intron|KCNH8_uc010hex.1_Intron	NM_144633	NP_653234			potassium voltage-gated channel, subfamily H,							integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5																		---	---	---	---
EFHB	151651	broad.mit.edu	37	3	19962069	19962069	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:19962069delA	uc003cbl.3	-						EFHB_uc003cbm.2_Intron	NM_144715	NP_653316			EF hand domain family, member B						signal transduction	proteinaceous extracellular matrix	calcium ion binding				0																		---	---	---	---
NEK10	152110	broad.mit.edu	37	3	27161156	27161157	+	Intron	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:27161156_27161157delAA	uc010hfk.2	-						NEK10_uc010hfj.2_Intron					RecName: Full=Serine/threonine-protein kinase Nek10;          EC=2.7.11.1; AltName: Full=NimA-related protein kinase 10;								ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(5)|stomach(2)|central_nervous_system(2)|lung(2)|skin(1)|pancreas(1)	13																		---	---	---	---
EOMES	8320	broad.mit.edu	37	3	27761564	27761564	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:27761564delA	uc003cdx.2	-						EOMES_uc003cdy.3_Intron|EOMES_uc010hfn.2_Intron|EOMES_uc011axc.1_Intron	NM_005442	NP_005433			eomesodermin						CD8-positive, alpha-beta T cell differentiation involved in immune response|cell differentiation involved in embryonic placenta development|endoderm formation|mesoderm formation|mesodermal to mesenchymal transition involved in gastrulation|positive regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|breast(1)	4																		---	---	---	---
AZI2	64343	broad.mit.edu	37	3	28373932	28373932	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:28373932delA	uc003ceb.2	-						AZI2_uc003cec.2_Intron|AZI2_uc003ced.2_Intron|AZI2_uc003cee.3_Intron|AZI2_uc003ceg.2_Intron|AZI2_uc011axd.1_Intron|AZI2_uc003cef.2_Intron	NM_022461	NP_071906			5-azacytidine induced 2 isoform a							mitochondrion|plasma membrane				ovary(2)	2																		---	---	---	---
ZCWPW2	152098	broad.mit.edu	37	3	28489611	28489611	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:28489611delA	uc003ceh.2	+						ZCWPW2_uc003cei.2_Intron|ZCWPW2_uc010hfo.2_Intron	NM_001040432	NP_001035522			zinc finger, CW type with PWWP domain 2								zinc ion binding			ovary(2)	2																		---	---	---	---
ZCWPW2	152098	broad.mit.edu	37	3	28562316	28562318	+	Intron	DEL	ATA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:28562316_28562318delATA	uc003ceh.2	+						ZCWPW2_uc003cei.2_Intron|ZCWPW2_uc010hfo.2_Intron	NM_001040432	NP_001035522			zinc finger, CW type with PWWP domain 2								zinc ion binding			ovary(2)	2																		---	---	---	---
RBMS3	27303	broad.mit.edu	37	3	29941481	29941482	+	Intron	DEL	GA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:29941481_29941482delGA	uc003cel.2	+						RBMS3_uc003cek.2_Intron|RBMS3_uc010hfq.2_Intron|RBMS3_uc003cem.2_Intron|RBMS3_uc010hfr.2_Intron	NM_001003793	NP_001003793			RNA binding motif, single stranded interacting							cytoplasm	nucleotide binding|RNA binding			central_nervous_system(1)	1		Ovarian(412;0.0956)																---	---	---	---
CMTM8	152189	broad.mit.edu	37	3	32301786	32301786	+	Intron	DEL	A	-	-	rs6796318	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:32301786delA	uc003cex.2	+						CMTM8_uc010hfu.2_Intron	NM_178868	NP_849199			CKLF-like MARVEL transmembrane domain containing						chemotaxis	extracellular space|integral to membrane	cytokine activity				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	3	32827947	32827948	+	IGR	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:32827947_32827948insA								CNOT10 (12593 upstream) : TRIM71 (31562 downstream)																																			---	---	---	---
CLASP2	23122	broad.mit.edu	37	3	33586494	33586494	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:33586494delA	uc003cfu.2	-						CLASP2_uc003cfs.2_Intron|CLASP2_uc003cft.2_Intron|CLASP2_uc010hgb.2_Intron|CLASP2_uc011axt.1_Intron	NM_015097	NP_055912			CLIP-associating protein 2											ovary(3)|central_nervous_system(1)	4																		---	---	---	---
PDCD6IP	10015	broad.mit.edu	37	3	33866811	33866811	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:33866811delT	uc003cfx.2	+	5	750	c.595delT	c.(595-597)TTTfs	p.F199fs	PDCD6IP_uc011axv.1_Frame_Shift_Del_p.F199fs|PDCD6IP_uc003cfy.2_Frame_Shift_Del_p.F199fs	NM_013374	NP_037506	Q8WUM4	PDC6I_HUMAN	programmed cell death 6 interacting protein	199	Interaction with EIAV p9.|Interaction with CHMP4A, CHMP4B and CHMP4C.|BRO1.			F->D: Abolishes interaction with CHMP4B and abolishes rescue of PTAP-type L domain-deficient HIV-1 p6.	apoptosis|cell cycle|cell division|interspecies interaction between organisms|protein transport	cytosol|melanosome|microtubule organizing center	calcium-dependent protein binding			ovary(1)|skin(1)	2																		---	---	---	---
MLH1	4292	broad.mit.edu	37	3	37042349	37042349	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:37042349delT	uc003cgl.2	+						MLH1_uc011aye.1_Intron|MLH1_uc011ayb.1_Intron|MLH1_uc010hge.2_Intron|MLH1_uc003cgn.3_Intron|MLH1_uc011ayc.1_Intron|MLH1_uc011ayd.1_Intron|MLH1_uc003cgo.2_Intron	NM_000249	NP_000240			MutL protein homolog 1						mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding			large_intestine(40)|haematopoietic_and_lymphoid_tissue(8)|ovary(6)|pancreas(5)|stomach(3)|central_nervous_system(3)|endometrium(3)|breast(3)|prostate(3)|skin(2)|NS(1)	77							1	D|Mis|N|F|S		colorectal|endometrial|ovarian|CNS	colorectal|endometrial|ovarian|CNS		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				---	---	---	---
GOLGA4	2803	broad.mit.edu	37	3	37317786	37317786	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:37317786delA	uc003cgv.2	+						GOLGA4_uc010hgr.1_Intron|GOLGA4_uc003cgw.2_Intron|GOLGA4_uc010hgs.2_Intron|GOLGA4_uc003cgu.1_Intron	NM_002078	NP_002069			golgi autoantigen, golgin subfamily a, 4						Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4																		---	---	---	---
GOLGA4	2803	broad.mit.edu	37	3	37330703	37330703	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:37330703delT	uc003cgv.2	+						GOLGA4_uc010hgr.1_Intron|GOLGA4_uc003cgw.2_Intron|GOLGA4_uc010hgs.2_Intron|GOLGA4_uc003cgx.2_Intron|GOLGA4_uc003cgu.1_Intron	NM_002078	NP_002069			golgi autoantigen, golgin subfamily a, 4						Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4																		---	---	---	---
CSRNP1	64651	broad.mit.edu	37	3	39186123	39186124	+	Intron	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:39186123_39186124delAA	uc003cjg.2	-						CSRNP1_uc003cjh.2_Intron	NM_033027	NP_149016			AXIN1 up-regulated 1						apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(4)|skin(1)	5																		---	---	---	---
ULK4	54986	broad.mit.edu	37	3	41973526	41973526	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:41973526delA	uc003ckv.3	-						ULK4_uc003ckw.2_Intron|ULK4_uc003ckx.1_Intron	NM_017886	NP_060356			unc-51-like kinase 4								ATP binding|protein serine/threonine kinase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.214)														---	---	---	---
NKTR	4820	broad.mit.edu	37	3	42681445	42681446	+	Intron	INS	-	CT	CT	rs150466796	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:42681445_42681446insCT	uc003clo.2	+						NKTR_uc003clp.2_Intron|NKTR_uc011azp.1_Intron|NKTR_uc003cls.2_Intron	NM_005385	NP_005376			natural killer-tumor recognition sequence						protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)														---	---	---	---
C3orf23	285343	broad.mit.edu	37	3	44399534	44399534	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:44399534delT	uc010him.2	+						C3orf23_uc003cnd.3_Intron|C3orf23_uc003cne.3_Intron|C3orf23_uc003cnb.3_Intron|C3orf23_uc003cnc.3_Intron	NM_173826	NP_776187			hypothetical protein LOC285343 isoform 1							mitochondrion				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(197;0.0468)|Kidney(197;0.0585)														---	---	---	---
ZNF197	10168	broad.mit.edu	37	3	44674311	44674312	+	Intron	INS	-	GT	GT	rs138347455	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:44674311_44674312insGT	uc003cnm.2	+						ZNF197_uc003cnn.2_Intron|ZNF197_uc003cno.2_Intron|ZNF197_uc003cnp.2_Intron	NM_006991	NP_008922			zinc finger protein 197 isoform 1						viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|skin(1)	4				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)														---	---	---	---
KIF15	56992	broad.mit.edu	37	3	44826565	44826565	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:44826565delA	uc003cnx.3	+						KIF15_uc010hiq.2_Intron	NM_020242	NP_064627			kinesin family member 15						blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)														---	---	---	---
KIF15	56992	broad.mit.edu	37	3	44836026	44836026	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:44836026delG	uc003cnx.3	+						KIF15_uc010hiq.2_Intron	NM_020242	NP_064627			kinesin family member 15						blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)														---	---	---	---
LRRC2	79442	broad.mit.edu	37	3	46560368	46560368	+	3'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:46560368delT	uc010hji.2	-	9					LRRC2_uc003cpu.3_3'UTR	NM_024512	NP_078788			leucine rich repeat containing 2											ovary(1)	1		Ovarian(412;0.0563)		OV - Ovarian serous cystadenocarcinoma(275;6.37e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00133)|KIRC - Kidney renal clear cell carcinoma(197;0.0214)|Kidney(197;0.0254)														---	---	---	---
LRRC2	79442	broad.mit.edu	37	3	46620407	46620407	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:46620407delT	uc003cpu.3	-						TDGF1_uc003cpv.2_Intron	NM_024750	NP_079026			leucine rich repeat containing 2											ovary(1)	1		Ovarian(412;0.0563)		OV - Ovarian serous cystadenocarcinoma(275;6.37e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00133)|KIRC - Kidney renal clear cell carcinoma(197;0.0214)|Kidney(197;0.0254)														---	---	---	---
KLHL18	23276	broad.mit.edu	37	3	47361081	47361082	+	Intron	DEL	TG	-	-	rs2302278	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:47361081_47361082delTG	uc003crd.2	+						KLHL18_uc003crc.2_Intron|KLHL18_uc011bav.1_Intron	NM_025010	NP_079286			kelch-like 18												0		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00645)|Kidney(197;0.00741)														---	---	---	---
SCAP	22937	broad.mit.edu	37	3	47476328	47476328	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:47476328delA	uc003crh.1	-						SCAP_uc011baz.1_Intron|SCAP_uc003crg.2_Intron	NM_012235	NP_036367			SREBF chaperone protein						cholesterol metabolic process|negative regulation of cholesterol biosynthetic process|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane	unfolded protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.00592)|Kidney(197;0.00679)														---	---	---	---
SMARCC1	6599	broad.mit.edu	37	3	47734801	47734801	+	Intron	DEL	A	-	-	rs145838606		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:47734801delA	uc003crq.2	-						SMARCC1_uc011bbd.1_Intron	NM_003074	NP_003065			SWI/SNF-related matrix-associated						chromatin remodeling|nervous system development|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex|WINAC complex	DNA binding|protein N-terminus binding|transcription coactivator activity			skin(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;7.47e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)														---	---	---	---
CELSR3	1951	broad.mit.edu	37	3	48686113	48686113	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:48686113delG	uc003cul.2	-						CELSR3_uc003cuf.1_Intron|CELSR3_uc010hkg.2_Intron	NM_001407	NP_001398			cadherin EGF LAG seven-pass G-type receptor 3						homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)														---	---	---	---
QARS	5859	broad.mit.edu	37	3	49135228	49135228	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49135228delA	uc003cvx.2	-						QARS_uc011bcc.1_Intron|QARS_uc011bcd.1_Intron|QARS_uc003cvy.2_Intron|QARS_uc011bce.1_Intron	NM_005051	NP_005042			glutaminyl-tRNA synthetase						glutaminyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|glutamine-tRNA ligase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)	L-Glutamine(DB00130)													---	---	---	---
QARS	5859	broad.mit.edu	37	3	49138212	49138212	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49138212delT	uc003cvx.2	-						QARS_uc011bcc.1_5'Flank|QARS_uc011bcd.1_Intron|QARS_uc003cvy.2_Intron|QARS_uc011bce.1_Intron|QARS_uc011bcf.1_Intron	NM_005051	NP_005042			glutaminyl-tRNA synthetase						glutaminyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|glutamine-tRNA ligase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)	L-Glutamine(DB00130)													---	---	---	---
USP4	7375	broad.mit.edu	37	3	49373143	49373143	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49373143delA	uc003cwq.2	-						USP4_uc003cwr.2_Intron	NM_003363	NP_003354			ubiquitin specific protease 4 isoform a						negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|urinary_tract(1)|lung(1)	4		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)														---	---	---	---
AMT	275	broad.mit.edu	37	3	49457336	49457336	+	Intron	DEL	A	-	-	rs34568346		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49457336delA	uc003cww.2	-						AMT_uc011bcn.1_Intron|AMT_uc003cwx.2_Intron|AMT_uc011bco.1_Intron|AMT_uc003cwy.2_Intron|AMT_uc011bcp.1_Intron|AMT_uc011bcq.1_Intron	NM_000481	NP_000472			aminomethyltransferase isoform 1 precursor						glycine catabolic process	mitochondrion	aminomethyltransferase activity|transaminase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)													---	---	---	---
RNF123	63891	broad.mit.edu	37	3	49757836	49757836	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49757836delG	uc003cxh.2	+						RNF123_uc003cxi.2_Intron|AMIGO3_uc003cxj.2_5'Flank	NM_022064	NP_071347			ring finger protein 123							cytoplasm	ligase activity|protein binding|zinc ion binding			kidney(3)|ovary(1)|lung(1)|breast(1)|skin(1)	7				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)														---	---	---	---
CACNA2D2	9254	broad.mit.edu	37	3	50403404	50403404	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:50403404delC	uc003daq.2	-						CACNA2D2_uc003dap.2_Intron|CACNA2D2_uc003dao.2_5'Flank	NM_006030	NP_006021			calcium channel, voltage-dependent, alpha						energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000365)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)	Gabapentin(DB00996)													---	---	---	---
DOCK3	1795	broad.mit.edu	37	3	50915118	50915118	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:50915118delT	uc011bds.1	+							NM_004947	NP_004938			dedicator of cytokinesis 3							cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)														---	---	---	---
RBM15B	29890	broad.mit.edu	37	3	51430740	51430742	+	In_Frame_Del	DEL	AGG	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:51430740_51430742delAGG	uc003dbd.2	+	1	2010_2012	c.1910_1912delAGG	c.(1909-1914)AAGGAG>AAG	p.E638del		NM_013286	NP_037418	Q8NDT2	RB15B_HUMAN	RNA binding motif protein 15B	638					interspecies interaction between organisms|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nucleoplasm	nucleotide binding|protein binding|RNA binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000224)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)														---	---	---	---
PCBP4	57060	broad.mit.edu	37	3	51991946	51991946	+	3'UTR	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:51991946delG	uc003dcd.1	-	12					PCBP4_uc003dcb.1_3'UTR|PCBP4_uc003dcc.1_3'UTR|PCBP4_uc003dce.1_3'UTR|PCBP4_uc003dcf.1_3'UTR|PCBP4_uc003dcg.1_3'UTR|PCBP4_uc003dch.1_3'UTR|PCBP4_uc003dci.1_3'UTR|PCBP4_uc003dcj.1_3'UTR|PCBP4_uc003dck.1_3'UTR|PCBP4_uc003dcl.1_3'UTR	NM_033010	NP_127503			poly(rC) binding protein 4 isoform c							cytoplasm|ribonucleoprotein complex	DNA binding|RNA binding				0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)														---	---	---	---
STAB1	23166	broad.mit.edu	37	3	52551288	52551288	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52551288delG	uc003dej.2	+						STAB1_uc003dek.1_5'Flank	NM_015136	NP_055951			stabilin 1 precursor						cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)														---	---	---	---
GLT8D1	55830	broad.mit.edu	37	3	52731828	52731828	+	Frame_Shift_Del	DEL	C	-	-	rs115960994	byFrequency;by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52731828delC	uc003dfi.3	-	4	377	c.238delG	c.(238-240)GCCfs	p.A80fs	GLT8D1_uc003dfj.2_Frame_Shift_Del_p.A80fs|GLT8D1_uc003dfk.2_Frame_Shift_Del_p.A80fs|GLT8D1_uc003dfl.2_Frame_Shift_Del_p.A80fs|GLT8D1_uc003dfm.2_Frame_Shift_Del_p.A80fs|GLT8D1_uc003dfn.2_Frame_Shift_Del_p.A80fs|GLT8D1_uc003dfo.1_Frame_Shift_Del_p.A80fs	NM_152932	NP_690909	Q68CQ7	GL8D1_HUMAN	glycosyltransferase 8 domain containing 1	80	Lumenal (Potential).					integral to membrane|mitochondrion	transferase activity, transferring glycosyl groups				0				BRCA - Breast invasive adenocarcinoma(193;6.78e-05)|Kidney(197;0.000618)|KIRC - Kidney renal clear cell carcinoma(197;0.000779)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)														---	---	---	---
NEK4	6787	broad.mit.edu	37	3	52768925	52768925	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52768925delA	uc003dfq.3	-						NEK4_uc011bej.1_Intron	NM_003157	NP_003148			NIMA-related kinase 4						cell division|mitosis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(1)	1				BRCA - Breast invasive adenocarcinoma(193;7.44e-05)|Kidney(197;0.000711)|KIRC - Kidney renal clear cell carcinoma(197;0.00086)|OV - Ovarian serous cystadenocarcinoma(275;0.0513)														---	---	---	---
CCDC66	285331	broad.mit.edu	37	3	56597857	56597857	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:56597857delA	uc003dhz.2	+	4	335	c.248delA	c.(247-249)GAAfs	p.E83fs	CCDC66_uc003dhy.2_5'UTR|CCDC66_uc003dhu.2_Frame_Shift_Del_p.E49fs|CCDC66_uc003dhx.2_RNA|CCDC66_uc003dhv.2_RNA|CCDC66_uc003dhw.2_Frame_Shift_Del_p.E83fs	NM_001141947	NP_001135419	A2RUB6	CCD66_HUMAN	coiled-coil domain containing 66 isoform 1	83										breast(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0478)|Kidney(284;0.0597)|OV - Ovarian serous cystadenocarcinoma(275;0.233)														---	---	---	---
C3orf63	23272	broad.mit.edu	37	3	56662794	56662795	+	Intron	DEL	TT	-	-	rs35779948		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:56662794_56662795delTT	uc003did.3	-						C3orf63_uc003dib.3_Intron|C3orf63_uc003dic.3_Intron|C3orf63_uc003die.3_Intron	NM_015224	NP_056039			retinoblastoma-associated protein 140 isoform b											ovary(3)|kidney(1)|central_nervous_system(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.0126)|Kidney(284;0.0147)														---	---	---	---
DNAH12	201625	broad.mit.edu	37	3	57528532	57528532	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:57528532delG	uc003dit.2	-	2	247	c.66delC	c.(64-66)CCCfs	p.P22fs	DNAH12_uc003diu.2_Frame_Shift_Del_p.P22fs	NM_178504	NP_848599	Q6ZR08	DYH12_HUMAN	dynein heavy chain domain 2 isoform 1	22	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			pancreas(1)|skin(1)	2																		---	---	---	---
ABHD6	57406	broad.mit.edu	37	3	58256869	58256869	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:58256869delT	uc003djs.3	+						ABHD6_uc003djr.2_Intron|ABHD6_uc003djt.3_Intron	NM_020676	NP_065727			abhydrolase domain containing 6							integral to membrane	acylglycerol lipase activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(55;0.000225)|KIRC - Kidney renal clear cell carcinoma(284;0.0471)|Kidney(284;0.0589)|OV - Ovarian serous cystadenocarcinoma(275;0.209)														---	---	---	---
C3orf67	200844	broad.mit.edu	37	3	58852557	58852557	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:58852557delT	uc003dkt.1	-						C3orf67_uc003dks.1_Intron|uc003dku.1_Intron|C3orf67_uc003dkv.1_Intron|C3orf67_uc003dkw.2_Intron	NM_198463	NP_940865			hypothetical protein LOC200844												0		all_cancers(2;0.000156)|all_epithelial(2;0.000493)|Breast(2;0.00446)|all_lung(2;0.074)|Lung NSC(2;0.248)		BRCA - Breast invasive adenocarcinoma(55;5.93e-06)|Kidney(10;0.00155)|KIRC - Kidney renal clear cell carcinoma(10;0.00172)|OV - Ovarian serous cystadenocarcinoma(275;0.23)														---	---	---	---
PRICKLE2	166336	broad.mit.edu	37	3	64160718	64160718	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:64160718delA	uc003dmf.2	-							NM_198859	NP_942559			prickle-like 2							cytoplasm|nuclear membrane	zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)														---	---	---	---
LRIG1	26018	broad.mit.edu	37	3	66463219	66463220	+	Intron	INS	-	CA	CA			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:66463219_66463220insCA	uc003dmx.2	-						LRIG1_uc010hnz.2_Intron|LRIG1_uc010hoa.2_Intron	NM_015541	NP_056356			leucine-rich repeats and immunoglobulin-like							integral to membrane				skin(3)|ovary(2)	5		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)														---	---	---	---
Unknown	0	broad.mit.edu	37	3	66687519	66687519	+	IGR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:66687519delA								LRIG1 (136674 upstream) : KBTBD8 (361208 downstream)																																			---	---	---	---
FRMD4B	23150	broad.mit.edu	37	3	69336796	69336796	+	Intron	DEL	T	-	-	rs78688753		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:69336796delT	uc003dnv.2	-						FRMD4B_uc003dnw.2_Intron|FRMD4B_uc003dnx.1_Intron	NM_015123	NP_055938			FERM domain containing 4B							cytoplasm|cytoskeleton	binding			ovary(3)|central_nervous_system(1)	4		Lung NSC(201;0.0138)|Prostate(884;0.11)		BRCA - Breast invasive adenocarcinoma(55;0.000201)|Epithelial(33;0.00141)|LUSC - Lung squamous cell carcinoma(21;0.00999)|Lung(16;0.0182)														---	---	---	---
ROBO2	6092	broad.mit.edu	37	3	77571803	77571804	+	Intron	DEL	TG	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:77571803_77571804delTG	uc003dpy.3	+						ROBO2_uc003dpz.2_Intron|ROBO2_uc011bgj.1_Intron|ROBO2_uc011bgk.1_Intron	NM_002942	NP_002933			roundabout, axon guidance receptor, homolog 2						apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)														---	---	---	---
ROBO1	6091	broad.mit.edu	37	3	78710235	78710235	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:78710235delA	uc003dqe.2	-	16	2473	c.2265delT	c.(2263-2265)TTTfs	p.F755fs	ROBO1_uc003dqb.2_Frame_Shift_Del_p.F716fs|ROBO1_uc003dqc.2_Frame_Shift_Del_p.F719fs|ROBO1_uc003dqd.2_Frame_Shift_Del_p.F719fs|ROBO1_uc010hoh.2_5'UTR|ROBO1_uc011bgl.1_Frame_Shift_Del_p.F327fs|ROBO1_uc003dqf.1_Frame_Shift_Del_p.F434fs	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	755	Extracellular (Potential).|Fibronectin type-III 2.				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)														---	---	---	---
ROBO1	6091	broad.mit.edu	37	3	78767037	78767037	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:78767037delA	uc003dqe.2	-						ROBO1_uc003dqb.2_Intron|ROBO1_uc003dqc.2_Intron|ROBO1_uc003dqd.2_Intron|ROBO1_uc003dqf.1_5'Flank	NM_002941	NP_002932			roundabout 1 isoform a						activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)														---	---	---	---
ARL13B	200894	broad.mit.edu	37	3	93707631	93707633	+	Intron	DEL	TTT	-	-	rs144136221		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:93707631_93707633delTTT	uc003drc.2	+						ARL13B_uc010hop.2_Intron|ARL13B_uc003drd.2_Intron|ARL13B_uc003dre.2_Intron|ARL13B_uc003drf.2_Intron|ARL13B_uc003drg.2_Intron	NM_182896	NP_878899			ADP-ribosylation factor-like 2-like 1 isoform 1								GTP binding				0																		---	---	---	---
ARL6	84100	broad.mit.edu	37	3	97486848	97486848	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:97486848delT	uc003drv.2	+						ARL6_uc003drw.2_Intron|ARL6_uc003dru.2_Intron|ARL6_uc010hoy.2_Intron	NM_177976	NP_816931			ADP-ribosylation factor-like 6						cilium assembly|determination of left/right symmetry|melanosome transport|protein polymerization|protein targeting to membrane|small GTPase mediated signal transduction|visual perception|Wnt receptor signaling pathway	axonemal microtubule|cilium axoneme|cilium membrane|membrane coat|microtubule basal body	GTP binding|metal ion binding|phospholipid binding|protein binding				0		Lung NSC(201;0.0193)|Prostate(884;0.174)		LUSC - Lung squamous cell carcinoma(29;0.0118)|Lung(72;0.0189)										Bardet-Biedl_syndrome				---	---	---	---
CRYBG3	131544	broad.mit.edu	37	3	97617958	97617959	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:97617958_97617959insT	uc003drx.2	+							NM_153605	NP_705833			beta-gamma crystallin domain containing 3												0																		---	---	---	---
OR5K2	402135	broad.mit.edu	37	3	98216757	98216757	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:98216757delC	uc011bgx.1	+	1	233	c.233delC	c.(232-234)ACCfs	p.T78fs		NM_001004737	NP_001004737	Q8NHB8	OR5K2_HUMAN	olfactory receptor, family 5, subfamily K,	78	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2																		---	---	---	---
ABI3BP	25890	broad.mit.edu	37	3	100581129	100581129	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:100581129delT	uc003dun.2	-						ABI3BP_uc003duo.2_Intron	NM_015429	NP_056244			ABI gene family, member 3 (NESH) binding protein							extracellular space				ovary(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)	4																		---	---	---	---
IMPG2	50939	broad.mit.edu	37	3	101038230	101038230	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:101038230delA	uc003duq.1	-						IMPG2_uc011bhe.1_Intron	NM_016247	NP_057331			interphotoreceptor matrix proteoglycan 2						visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3																		---	---	---	---
PCNP	57092	broad.mit.edu	37	3	101311692	101311692	+	3'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:101311692delT	uc003dva.2	+	5					PCNP_uc003dvb.2_RNA|PCNP_uc003dvc.2_RNA|PCNP_uc003dvd.2_3'UTR	NM_020357	NP_065090			PEST proteolytic signal containing nuclear						cell cycle|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	nucleus	protein binding				0																		---	---	---	---
HHLA2	11148	broad.mit.edu	37	3	108044959	108044959	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:108044959delT	uc003dwy.3	+						HHLA2_uc011bhl.1_Intron|HHLA2_uc010hpu.2_Intron|HHLA2_uc003dwz.2_Intron	NM_007072	NP_009003			HERV-H LTR-associating 2 precursor							integral to membrane				ovary(1)	1																		---	---	---	---
KIAA1524	57650	broad.mit.edu	37	3	108300479	108300479	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:108300479delA	uc003dxb.3	-						KIAA1524_uc003dxc.1_Intron|KIAA1524_uc010hpw.1_Intron	NM_020890	NP_065941			p90 autoantigen							cytoplasm|integral to membrane	protein binding			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
MORC1	27136	broad.mit.edu	37	3	108819090	108819090	+	Intron	DEL	A	-	-	rs78907417		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:108819090delA	uc003dxl.2	-						MORC1_uc011bhn.1_Intron	NM_014429	NP_055244			MORC family CW-type zinc finger 1						cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8																		---	---	---	---
PHLDB2	90102	broad.mit.edu	37	3	111671328	111671328	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:111671328delT	uc010hqa.2	+						PHLDB2_uc003dyc.2_Intron|PHLDB2_uc003dyd.2_Intron|PHLDB2_uc003dyg.2_Intron|PHLDB2_uc003dyh.2_Intron|PHLDB2_uc003dyi.2_Intron	NM_001134438	NP_001127910			pleckstrin homology-like domain, family B,							cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6																		---	---	---	---
GCET2	257144	broad.mit.edu	37	3	111846844	111846844	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:111846844delA	uc003dys.1	-						C3orf52_uc011bht.1_Intron|C3orf52_uc003dyr.1_Intron|GCET2_uc003dyt.1_Intron	NM_152785	NP_689998			germinal center expressed transcript 2 isoform							mitochondrion					0																		---	---	---	---
C3orf17	25871	broad.mit.edu	37	3	112736131	112736131	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:112736131delA	uc003dzr.2	-						C3orf17_uc011bhz.1_Intron|C3orf17_uc010hqh.2_Intron|C3orf17_uc003dzt.2_Intron|C3orf17_uc003dzs.2_Intron|C3orf17_uc010hqg.2_Intron|C3orf17_uc011bia.1_Intron|C3orf17_uc003dzu.2_Intron|C3orf17_uc011bib.1_Intron|C3orf17_uc011bic.1_Intron|C3orf17_uc011bid.1_Intron	NM_015412	NP_056227			hypothetical protein LOC25871							integral to membrane					0																		---	---	---	---
NAA50	80218	broad.mit.edu	37	3	113459588	113459589	+	Intron	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:113459588_113459589delTT	uc003ean.1	-						NAA50_uc010hqm.1_5'Flank|NAA50_uc011bij.1_Intron	NM_025146	NP_079422			N-acetyltransferase 13						N-terminal protein amino acid acetylation	cytoplasm	N-acetyltransferase activity|protein binding				0																		---	---	---	---
QTRTD1	79691	broad.mit.edu	37	3	113784381	113784381	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:113784381delT	uc003eay.2	+						QTRTD1_uc003eaz.2_Intron|QTRTD1_uc011biq.1_Intron|QTRTD1_uc011bir.1_Intron|QTRTD1_uc003eba.2_5'Flank	NM_024638	NP_078914			queuine tRNA-ribosyltransferase domain						queuosine biosynthetic process	mitochondrion	metal ion binding|queuine tRNA-ribosyltransferase activity			central_nervous_system(1)|skin(1)	2																		---	---	---	---
ZBTB20	26137	broad.mit.edu	37	3	114058003	114058003	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:114058003delG	uc003ebi.2	-	5	2255	c.2075delC	c.(2074-2076)CCTfs	p.P692fs	ZBTB20_uc003ebj.2_Frame_Shift_Del_p.P619fs|ZBTB20_uc010hqp.2_Frame_Shift_Del_p.P619fs|ZBTB20_uc003ebk.2_Frame_Shift_Del_p.P619fs|ZBTB20_uc003ebl.2_Frame_Shift_Del_p.P619fs|ZBTB20_uc003ebm.2_Frame_Shift_Del_p.P619fs|ZBTB20_uc003ebn.2_Frame_Shift_Del_p.P619fs	NM_015642	NP_056457	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20 isoform	692					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)														---	---	---	---
GAP43	2596	broad.mit.edu	37	3	115342811	115342811	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:115342811delT	uc003ebq.2	+						GAP43_uc003ebr.2_Intron	NM_002045	NP_002036			growth associated protein 43 isoform 2						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell differentiation|nervous system development|regulation of filopodium assembly|regulation of growth|response to wounding	cell junction|filopodium membrane|growth cone membrane|synapse	calmodulin binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.164)														---	---	---	---
POLQ	10721	broad.mit.edu	37	3	121192140	121192141	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:121192140_121192141insA	uc003eee.3	-						POLQ_uc003eed.2_Intron	NM_199420	NP_955452			DNA polymerase theta						DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)									DNA_polymerases_(catalytic_subunits)					---	---	---	---
POLQ	10721	broad.mit.edu	37	3	121252061	121252061	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:121252061delA	uc003eee.3	-							NM_199420	NP_955452			DNA polymerase theta						DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)									DNA_polymerases_(catalytic_subunits)					---	---	---	---
HSPBAP1	79663	broad.mit.edu	37	3	122474338	122474340	+	Intron	DEL	GAA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:122474338_122474340delGAA	uc003efu.1	-						HSPBAP1_uc003efv.1_Intron	NM_024610	NP_078886			Hspb associated protein 1							cytoplasm				ovary(1)|lung(1)	2				GBM - Glioblastoma multiforme(114;0.0531)														---	---	---	---
PDIA5	10954	broad.mit.edu	37	3	122843200	122843201	+	Intron	DEL	GT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:122843200_122843201delGT	uc003egc.1	+						PDIA5_uc003egd.1_Intron	NM_006810	NP_006801			protein disulfide isomerase A5 precursor						cell redox homeostasis|glycerol ether metabolic process|protein folding|response to stress	endoplasmic reticulum lumen	electron carrier activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.0427)														---	---	---	---
CCDC14	64770	broad.mit.edu	37	3	123671343	123671343	+	Intron	DEL	T	-	-	rs2682197	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:123671343delT	uc011bjx.1	-						CCDC14_uc003egv.3_Intron|CCDC14_uc003egx.3_Intron|CCDC14_uc010hrt.2_Intron|CCDC14_uc003egy.3_Intron|CCDC14_uc003egz.2_Intron	NM_022757	NP_073594			coiled-coil domain containing 14							centrosome					0		Lung NSC(201;0.0371)|Prostate(884;0.0405)|Myeloproliferative disorder(1037;0.205)		Lung(219;0.00942)|GBM - Glioblastoma multiforme(114;0.159)														---	---	---	---
SNX4	8723	broad.mit.edu	37	3	125176041	125176044	+	Intron	DEL	GAGT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:125176041_125176044delGAGT	uc003eib.2	-						SNX4_uc011bkf.1_Intron	NM_003794	NP_003785			sorting nexin 4						cell communication|endocytic recycling|endocytosis|protein transport	cytoplasmic dynein complex|early endosome membrane	phosphatidylinositol binding|protein binding			breast(2)|ovary(1)|central_nervous_system(1)	4																		---	---	---	---
SNX4	8723	broad.mit.edu	37	3	125223328	125223328	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:125223328delA	uc003eib.2	-						SNX4_uc011bkf.1_Intron	NM_003794	NP_003785			sorting nexin 4						cell communication|endocytic recycling|endocytosis|protein transport	cytoplasmic dynein complex|early endosome membrane	phosphatidylinositol binding|protein binding			breast(2)|ovary(1)|central_nervous_system(1)	4																		---	---	---	---
MCM2	4171	broad.mit.edu	37	3	127338244	127338244	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:127338244delA	uc003ejp.2	+						MCM2_uc011bkm.1_Intron|MCM2_uc010hsl.2_Intron|MCM2_uc011bkn.1_Intron	NM_004526	NP_004517			minichromosome maintenance complex component 2						cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|helicase activity|metal ion binding			ovary(3)|skin(1)	4																		---	---	---	---
KIAA1257	57501	broad.mit.edu	37	3	128697246	128697246	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:128697246delA	uc003elj.3	-						KIAA1257_uc003elg.1_Intron|KIAA1257_uc003eli.3_Intron	NM_020741	NP_065792			hypothetical protein LOC57501												0																		---	---	---	---
COPG	22820	broad.mit.edu	37	3	128974023	128974023	+	Intron	DEL	T	-	-	rs63166061		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:128974023delT	uc003els.2	+						COPG_uc010htb.2_Intron	NM_016128	NP_057212			coatomer protein complex, subunit gamma 1						COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(3)|breast(1)	4																		---	---	---	---
COL6A6	131873	broad.mit.edu	37	3	130381353	130381353	+	Intron	DEL	T	-	-	rs146981165		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:130381353delT	uc010htl.2	+						COL6A6_uc003eni.3_Intron	NM_001102608	NP_001096078			collagen type VI alpha 6 precursor						axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8																		---	---	---	---
TMEM108	66000	broad.mit.edu	37	3	133108760	133108761	+	Intron	INS	-	TGA	TGA	rs150571153	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:133108760_133108761insTGA	uc003eph.2	+						TMEM108_uc003epi.2_Intron|TMEM108_uc003epk.2_Intron|TMEM108_uc003epm.2_Intron	NM_023943	NP_076432			transmembrane protein 108 precursor							integral to membrane				ovary(2)|skin(2)	4																		---	---	---	---
TOPBP1	11073	broad.mit.edu	37	3	133342879	133342879	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:133342879delA	uc003eps.2	-						TOPBP1_uc003ept.1_Intron	NM_007027	NP_008958			topoisomerase (DNA) II binding protein 1						DNA repair|response to ionizing radiation	microtubule organizing center|PML body|spindle pole	DNA binding|protein C-terminus binding			ovary(2)|kidney(2)|skin(1)|lung(1)|pancreas(1)	7													Other_conserved_DNA_damage_response_genes					---	---	---	---
TOPBP1	11073	broad.mit.edu	37	3	133361872	133361872	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:133361872delT	uc003eps.2	-							NM_007027	NP_008958			topoisomerase (DNA) II binding protein 1						DNA repair|response to ionizing radiation	microtubule organizing center|PML body|spindle pole	DNA binding|protein C-terminus binding			ovary(2)|kidney(2)|skin(1)|lung(1)|pancreas(1)	7													Other_conserved_DNA_damage_response_genes					---	---	---	---
TF	7018	broad.mit.edu	37	3	133423292	133423292	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:133423292delA	uc003epu.1	+							NM_001063	NP_001054			transferrin precursor						cellular iron ion homeostasis|platelet activation|platelet degranulation|transferrin transport|transmembrane transport	apical plasma membrane|basal plasma membrane|coated pit|early endosome|endocytic vesicle|endosome membrane|extracellular region|late endosome|perinuclear region of cytoplasm|recycling endosome|stored secretory granule	ferric iron binding			ovary(1)|skin(1)	2					Aluminium(DB01370)|Bismuth(DB01402)|Iron Dextran(DB00893)													---	---	---	---
TF	7018	broad.mit.edu	37	3	133465342	133465342	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:133465342delG	uc003epu.1	+						TF_uc011bls.1_Intron|TF_uc011blt.1_Intron|TF_uc003epw.1_Intron|TF_uc010htv.1_Intron|TF_uc003epv.1_Intron	NM_001063	NP_001054			transferrin precursor						cellular iron ion homeostasis|platelet activation|platelet degranulation|transferrin transport|transmembrane transport	apical plasma membrane|basal plasma membrane|coated pit|early endosome|endocytic vesicle|endosome membrane|extracellular region|late endosome|perinuclear region of cytoplasm|recycling endosome|stored secretory granule	ferric iron binding			ovary(1)|skin(1)	2					Aluminium(DB01370)|Bismuth(DB01402)|Iron Dextran(DB00893)													---	---	---	---
TF	7018	broad.mit.edu	37	3	133483648	133483648	+	Intron	DEL	A	-	-	rs58479550	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:133483648delA	uc003epu.1	+						TF_uc011blt.1_Intron|TF_uc003epw.1_Intron|TF_uc003epv.1_Intron	NM_001063	NP_001054			transferrin precursor						cellular iron ion homeostasis|platelet activation|platelet degranulation|transferrin transport|transmembrane transport	apical plasma membrane|basal plasma membrane|coated pit|early endosome|endocytic vesicle|endosome membrane|extracellular region|late endosome|perinuclear region of cytoplasm|recycling endosome|stored secretory granule	ferric iron binding			ovary(1)|skin(1)	2					Aluminium(DB01370)|Bismuth(DB01402)|Iron Dextran(DB00893)													---	---	---	---
STAG1	10274	broad.mit.edu	37	3	136196265	136196265	+	Intron	DEL	A	-	-	rs77697102		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:136196265delA	uc003era.1	-						STAG1_uc003erb.1_Intron|STAG1_uc003erc.1_Intron|STAG1_uc010hua.1_Intron	NM_005862	NP_005853			stromal antigen 1						cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(2)	2																		---	---	---	---
NCK1	4690	broad.mit.edu	37	3	136618589	136618589	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:136618589delT	uc003erh.2	+							NM_006153	NP_006144			NCK adaptor protein 1						axon guidance|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of translation|signal complex assembly|T cell activation|T cell receptor signaling pathway	cytosol|endoplasmic reticulum|nucleus	cytoskeletal adaptor activity|receptor binding|receptor signaling complex scaffold activity			pancreas(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	3	138497083	138497083	+	IGR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:138497083delA								PIK3CB (18898 upstream) : FOXL2 (165984 downstream)																																			---	---	---	---
CLSTN2	64084	broad.mit.edu	37	3	140251449	140251449	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:140251449delA	uc003etn.2	+						CLSTN2_uc003etm.2_Intron	NM_022131	NP_071414			calsyntenin 2 precursor						homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7															HNSCC(16;0.037)			---	---	---	---
XRN1	54464	broad.mit.edu	37	3	142051517	142051517	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:142051517delA	uc003eus.2	-						XRN1_uc010huu.2_Intron|XRN1_uc003eut.2_Intron|XRN1_uc003euu.2_Intron	NM_019001	NP_061874			5'-3' exoribonuclease 1 isoform a						exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3																		---	---	---	---
XRN1	54464	broad.mit.edu	37	3	142142409	142142409	+	Frame_Shift_Del	DEL	T	-	-	rs139790121		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:142142409delT	uc003eus.2	-	6	770	c.703delA	c.(703-705)ACAfs	p.T235fs	XRN1_uc003eut.2_Frame_Shift_Del_p.T235fs|XRN1_uc003euu.2_Frame_Shift_Del_p.T235fs|XRN1_uc003euv.1_Frame_Shift_Del_p.T96fs|XRN1_uc003euw.2_Frame_Shift_Del_p.T235fs|XRN1_uc011bnh.1_Frame_Shift_Del_p.T25fs	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a	235					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3																		---	---	---	---
ATR	545	broad.mit.edu	37	3	142266538	142266538	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:142266538delA	uc003eux.3	-							NM_001184	NP_001175			ataxia telangiectasia and Rad3 related protein						cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20													Other_conserved_DNA_damage_response_genes					---	---	---	---
PLS1	5357	broad.mit.edu	37	3	142402698	142402700	+	Intron	DEL	TTT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:142402698_142402700delTTT	uc010huv.2	+						PLS1_uc003euz.2_Intron|PLS1_uc003eva.2_Intron	NM_001145319	NP_001138791			plastin 1							cytoplasm	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(1)	1																		---	---	---	---
SLC9A9	285195	broad.mit.edu	37	3	143186041	143186041	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:143186041delA	uc003evn.2	-							NM_173653	NP_775924			solute carrier family 9 (sodium/hydrogen						regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			ovary(2)|skin(1)	3																		---	---	---	---
HPS3	84343	broad.mit.edu	37	3	148871545	148871545	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:148871545delT	uc003ewu.1	+						HPS3_uc003ewt.1_3'UTR|HPS3_uc011bnq.1_Intron	NM_032383	NP_115759			Hermansky-Pudlak syndrome 3 protein							cytoplasm				ovary(5)|large_intestine(1)	6			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)											Hermansky-Pudlak_syndrome				---	---	---	---
CP	1356	broad.mit.edu	37	3	148923939	148923939	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:148923939delT	uc003ewy.3	-						CP_uc011bnr.1_Intron|CP_uc003ewx.3_Intron|CP_uc003ewz.2_Intron|CP_uc010hvf.1_Intron	NM_000096	NP_000087			ceruloplasmin precursor						cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			ovary(1)	1		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)													---	---	---	---
CP	1356	broad.mit.edu	37	3	148926960	148926960	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:148926960delA	uc003ewy.3	-						CP_uc011bnr.1_Intron|CP_uc003ewx.3_Intron|CP_uc003ewz.2_Intron|CP_uc010hvf.1_5'Flank	NM_000096	NP_000087			ceruloplasmin precursor						cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			ovary(1)	1		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)													---	---	---	---
TM4SF18	116441	broad.mit.edu	37	3	149048097	149048097	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:149048097delA	uc003exa.2	-							NM_138786	NP_620141			transmembrane 4 L six family member 18							integral to membrane				ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)															---	---	---	---
RNF13	11342	broad.mit.edu	37	3	149638898	149638898	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:149638898delT	uc003exn.3	+						RNF13_uc003exp.3_Intron|RNF13_uc010hvh.2_Intron	NM_007282	NP_009213			ring finger protein 13						protein autoubiquitination	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane|nuclear inner membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		all_neural(597;0.0138)|Myeloproliferative disorder(1037;0.0255)	LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)															---	---	---	---
EIF2A	83939	broad.mit.edu	37	3	150285470	150285470	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:150285470delT	uc003eya.2	+						SERP1_uc003exz.2_Intron|EIF2A_uc003eyb.2_Intron|EIF2A_uc003eyc.2_Intron|EIF2A_uc011bnv.1_Intron|EIF2A_uc011bnw.1_Intron|EIF2A_uc003eyd.2_Intron|uc003eye.1_Intron	NM_032025	NP_114414			eukaryotic translation initiation factor 2A						regulation of translation|ribosome assembly	eukaryotic translation initiation factor 2 complex	ribosome binding|translation initiation factor activity|tRNA binding				0		Melanoma(1037;0.0575)	LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)															---	---	---	---
FAM194A	131831	broad.mit.edu	37	3	150396154	150396154	+	Intron	DEL	T	-	-	rs72451674		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:150396154delT	uc003eyg.2	-						FAM194A_uc003eyh.2_Intron	NM_152394	NP_689607			hypothetical protein LOC131831											skin(2)|ovary(1)	3																		---	---	---	---
MED12L	116931	broad.mit.edu	37	3	151086138	151086138	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:151086138delT	uc003eyp.2	+						MED12L_uc011bnz.1_Intron|P2RY12_uc011boa.1_Intron|P2RY12_uc003eyx.1_Intron|MED12L_uc003eyy.1_Intron	NM_053002	NP_443728			mediator of RNA polymerase II transcription,						regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)															---	---	---	---
PLCH1	23007	broad.mit.edu	37	3	155211803	155211804	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:155211803_155211804insA	uc011bok.1	-						PLCH1_uc011boj.1_Intron|PLCH1_uc011bol.1_Intron	NM_001130960	NP_001124432			phospholipase C eta 1 isoform a						lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)															---	---	---	---
C3orf33	285315	broad.mit.edu	37	3	155485190	155485190	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:155485190delA	uc003fal.1	-						C3orf33_uc003fam.1_Intron	NM_173657	NP_775928			hypothetical protein LOC285315								hydrolase activity, acting on ester bonds|nucleic acid binding				0			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)															---	---	---	---
TIPARP	25976	broad.mit.edu	37	3	156421055	156421055	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:156421055delT	uc003fav.2	+						TIPARP_uc003faw.2_Intron	NM_015508	NP_056323			TCDD-inducible poly(ADP-ribose) polymerase								NAD+ ADP-ribosyltransferase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)|breast(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)															---	---	---	---
CCNL1	57018	broad.mit.edu	37	3	156865888	156865889	+	3'UTR	DEL	TG	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:156865888_156865889delTG	uc003fbf.2	-	11					CCNL1_uc003fbd.1_Intron|CCNL1_uc003fbe.2_3'UTR|CCNL1_uc003fbg.2_RNA|CCNL1_uc011bor.1_RNA	NM_020307	NP_064703			cyclin L1						regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			lung(3)|breast(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(72;0.0295)|Lung(72;0.0308)															---	---	---	---
C3orf55	152078	broad.mit.edu	37	3	157295938	157295939	+	Intron	DEL	TT	-	-	rs11412238		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:157295938_157295939delTT	uc003fbp.3	+						C3orf55_uc003fbo.2_Intron|C3orf55_uc011bot.1_Intron|C3orf55_uc010hvv.2_Intron	NM_001130002	NP_001123474			hypothetical protein LOC152078 isoform 1												0			Lung(72;0.0215)|LUSC - Lung squamous cell carcinoma(72;0.037)															---	---	---	---
SHOX2	6474	broad.mit.edu	37	3	157818118	157818118	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:157818118delA	uc003fbr.2	-						SHOX2_uc003fbs.2_Intron|SHOX2_uc010hvw.2_Intron	NM_006884	NP_006875			short stature homeobox 2 isoform a						nervous system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			Lung(72;0.00318)|LUSC - Lung squamous cell carcinoma(72;0.0043)															---	---	---	---
MLF1	4291	broad.mit.edu	37	3	158317975	158317975	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:158317975delA	uc003fcb.2	+						MLF1_uc003fbz.2_Intron|MLF1_uc003fca.2_Intron|MLF1_uc003fbx.2_Intron|MLF1_uc003fcc.2_Intron|MLF1_uc003fby.2_Intron|MLF1_uc010hvx.2_Intron	NM_022443	NP_071888			myeloid leukemia factor 1 isoform 1						cell cycle arrest|myeloid progenitor cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein domain specific binding				0		Melanoma(1037;0.000458)|Prostate(884;0.0235)|all_neural(597;0.0299)	Lung(72;0.00199)|LUSC - Lung squamous cell carcinoma(72;0.00256)					T	NPM1	AML								---	---	---	---
MFSD1	64747	broad.mit.edu	37	3	158531731	158531731	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:158531731delT	uc003fcl.1	+						MFSD1_uc003fcm.1_Intron|MFSD1_uc003fcn.1_Intron|MFSD1_uc011bow.1_Intron|MFSD1_uc011box.1_Intron	NM_022736	NP_073573			major facilitator superfamily domain containing						transmembrane transport	integral to membrane					0			Lung(72;0.00372)|LUSC - Lung squamous cell carcinoma(72;0.00523)															---	---	---	---
SERPINI2	5276	broad.mit.edu	37	3	167189546	167189546	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:167189546delT	uc003fer.1	-	1	135	c.77delA	c.(76-78)AATfs	p.N26fs	SERPINI2_uc003fes.1_Frame_Shift_Del_p.N36fs|SERPINI2_uc003fet.1_Frame_Shift_Del_p.N26fs	NM_006217	NP_006208	O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin),	26					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			skin(2)|urinary_tract(1)	3																		---	---	---	---
PHC3	80012	broad.mit.edu	37	3	169847482	169847482	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:169847482delA	uc010hws.1	-						PHC3_uc003fgl.2_Intron|PHC3_uc011bpq.1_Intron|PHC3_uc011bpr.1_Intron	NM_024947	NP_079223			polyhomeotic like 3						multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_cancers(22;2.67e-22)|all_epithelial(15;4.73e-27)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)															---	---	---	---
PRKCI	5584	broad.mit.edu	37	3	169985594	169985594	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:169985594delT	uc003fgs.2	+							NM_002740	NP_002731			protein kinase C, iota						anti-apoptosis|cellular membrane organization|cellular response to insulin stimulus|establishment or maintenance of epithelial cell apical/basal polarity|intracellular signal transduction|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|protein targeting to membrane|secretion|tight junction assembly|vesicle-mediated transport	cytosol|endosome|nucleus|polarisome	ATP binding|phospholipid binding|protein binding|protein kinase C activity|zinc ion binding			lung(2)|ovary(1)|breast(1)|skin(1)	5	all_cancers(22;6.45e-23)|all_epithelial(15;8.52e-28)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)															---	---	---	---
EIF5A2	56648	broad.mit.edu	37	3	170611037	170611037	+	3'UTR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:170611037delA	uc003fhd.2	-	5						NM_020390	NP_065123			eIF-5A2 protein						mRNA transport|peptidyl-lysine modification to hypusine|polyamine homeostasis|positive regulation of cell proliferation|positive regulation of translational elongation|positive regulation of translational termination|post-translational protein modification|protein transport|spermatogenesis|translational frameshifting|transmembrane transport	cytosol|endoplasmic reticulum membrane|nuclear pore	protein binding|ribosome binding|translation elongation factor activity				0	all_cancers(22;1.61e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;9.8e-16)|Lung(28;4.28e-15)															---	---	---	---
EIF5A2	56648	broad.mit.edu	37	3	170625513	170625513	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:170625513delT	uc003fhd.2	-	2	213	c.83delA	c.(82-84)AACfs	p.N28fs		NM_020390	NP_065123	Q9GZV4	IF5A2_HUMAN	eIF-5A2 protein	28					mRNA transport|peptidyl-lysine modification to hypusine|polyamine homeostasis|positive regulation of cell proliferation|positive regulation of translational elongation|positive regulation of translational termination|post-translational protein modification|protein transport|spermatogenesis|translational frameshifting|transmembrane transport	cytosol|endoplasmic reticulum membrane|nuclear pore	protein binding|ribosome binding|translation elongation factor activity				0	all_cancers(22;1.61e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;9.8e-16)|Lung(28;4.28e-15)															---	---	---	---
TNIK	23043	broad.mit.edu	37	3	170824317	170824318	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:170824317_170824318insA	uc003fhh.2	-						TNIK_uc003fhi.2_Intron|TNIK_uc003fhj.2_Intron|TNIK_uc003fhk.2_Intron|TNIK_uc003fhl.2_Intron|TNIK_uc003fhm.2_Intron|TNIK_uc003fhn.2_Intron|TNIK_uc003fho.2_Intron	NM_015028	NP_055843			TRAF2 and NCK interacting kinase isoform 1						actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)															---	---	---	---
TNIK	23043	broad.mit.edu	37	3	170846677	170846683	+	Intron	DEL	AAAAAAA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:170846677_170846683delAAAAAAA	uc003fhh.2	-						TNIK_uc003fhi.2_Intron|TNIK_uc003fhj.2_Intron|TNIK_uc003fhk.2_Intron|TNIK_uc003fhl.2_Intron|TNIK_uc003fhm.2_Intron|TNIK_uc003fhn.2_Intron|TNIK_uc003fho.2_Intron	NM_015028	NP_055843			TRAF2 and NCK interacting kinase isoform 1						actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)															---	---	---	---
Unknown	0	broad.mit.edu	37	3	172144038	172144038	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:172144038delT								FNDC3B (25548 upstream) : GHSR (18913 downstream)																																			---	---	---	---
NAALADL2	254827	broad.mit.edu	37	3	175472857	175472857	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:175472857delA	uc003fit.2	+							NM_207015	NP_996898			N-acetylated alpha-linked acidic dipeptidase 2						proteolysis	integral to membrane	peptidase activity			pancreas(1)	1	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)														---	---	---	---
TBL1XR1	79718	broad.mit.edu	37	3	176769342	176769342	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:176769342delT	uc003fiw.3	-	5	637	c.377delA	c.(376-378)AATfs	p.N126fs	TBL1XR1_uc003fix.3_Frame_Shift_Del_p.N126fs|TBL1XR1_uc011bpz.1_Translation_Start_Site|TBL1XR1_uc003fiy.2_Frame_Shift_Del_p.N126fs	NM_024665	NP_078941	Q9BZK7	TBL1R_HUMAN	transducin (beta)-like 1 X-linked receptor 1	126					canonical Wnt receptor signaling pathway|cellular lipid metabolic process|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein N-terminus binding|transcription corepressor activity|transcription regulatory region DNA binding			ovary(1)	1	all_cancers(143;1.44e-17)|Ovarian(172;0.00163)|Breast(254;0.214)	Acute lymphoblastic leukemia(1;0.00599)|all_hematologic(1;0.0632)|Prostate(884;0.215)	OV - Ovarian serous cystadenocarcinoma(80;9.83e-31)															---	---	---	---
CCDC39	339829	broad.mit.edu	37	3	180337574	180337575	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:180337574_180337575insA	uc010hxe.2	-						CCDC39_uc003fkn.2_Intron	NM_181426	NP_852091			coiled-coil domain containing 39						axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				ovary(4)	4	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)															---	---	---	---
CCDC39	339829	broad.mit.edu	37	3	180379570	180379570	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:180379570delA	uc010hxe.2	-						CCDC39_uc003fkn.2_Intron	NM_181426	NP_852091			coiled-coil domain containing 39						axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				ovary(4)	4	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)															---	---	---	---
FXR1	8087	broad.mit.edu	37	3	180671370	180671370	+	Intron	DEL	T	-	-	rs75916673		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:180671370delT	uc003fkq.2	+						FXR1_uc003fkp.2_Intron|FXR1_uc003fkr.2_Intron|FXR1_uc011bqj.1_Intron|FXR1_uc003fks.2_Intron|FXR1_uc011bqk.1_Intron|FXR1_uc011bql.1_Intron	NM_005087	NP_005078			fragile X mental retardation-related protein 1						apoptosis|cell differentiation|muscle organ development	nucleolus|polysome				breast(1)	1	all_cancers(143;6.07e-14)|Ovarian(172;0.0212)		Epithelial(37;3.05e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.4e-22)															---	---	---	---
ATP11B	23200	broad.mit.edu	37	3	182587000	182587000	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:182587000delT	uc003flb.2	+						ATP11B_uc003flc.2_Intron	NM_014616	NP_055431			ATPase, class VI, type 11B						aminophospholipid transport|ATP biosynthetic process	integral to membrane|nuclear inner membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;1.2e-42)|Epithelial(37;2.77e-36)|LUSC - Lung squamous cell carcinoma(7;7.58e-24)|Lung(8;4.66e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.35e-20)															---	---	---	---
YEATS2	55689	broad.mit.edu	37	3	183436187	183436187	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:183436187delT	uc003fly.2	+							NM_018023	NP_060493			YEATS domain containing 2						histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			ovary(3)|large_intestine(1)	4	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)															---	---	---	---
ABCC5	10057	broad.mit.edu	37	3	183685490	183685490	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:183685490delA	uc003fmg.2	-	12	1991	c.1826delT	c.(1825-1827)TTAfs	p.L609fs	ABCC5_uc011bqt.1_Frame_Shift_Del_p.L137fs|ABCC5_uc010hxl.2_Frame_Shift_Del_p.L609fs	NM_005688	NP_005679	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C, member 5	609	Helical; (Potential).|ABC transporter 1.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)															---	---	---	---
HTR3E	285242	broad.mit.edu	37	3	183821908	183821908	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:183821908delT	uc010hxq.2	+						HTR3E_uc003fml.3_Intron|HTR3E_uc003fmm.2_Intron|HTR3E_uc010hxr.2_Intron|HTR3E_uc003fmn.2_Intron	NM_182589	NP_872395			5-hydroxytryptamine receptor 3 subunit E							integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)															---	---	---	---
VPS8	23355	broad.mit.edu	37	3	184742112	184742112	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:184742112delT	uc003fpb.1	+						VPS8_uc010hyd.1_Intron|VPS8_uc010hye.1_Intron	NM_015303	NP_056118			vacuolar protein sorting 8 homolog isoform b								zinc ion binding			ovary(1)	1	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)															---	---	---	---
TMEM41A	90407	broad.mit.edu	37	3	185212517	185212518	+	Frame_Shift_Ins	INS	-	A	A	rs150885877	byFrequency	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:185212517_185212518insA	uc003fpj.2	-	4	563_564	c.467_468insT	c.(466-468)TTCfs	p.F156fs	TMEM41A_uc003fpk.2_Intron|TMEM41A_uc003fpl.2_3'UTR	NM_080652	NP_542383	Q96HV5	TM41A_HUMAN	transmembrane protein 41A precursor	156	Helical; (Potential).					integral to membrane					0	all_cancers(143;7.78e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)															---	---	---	---
Unknown	0	broad.mit.edu	37	3	186544793	186544793	+	IGR	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:186544793delC								RFC4 (20309 upstream) : ADIPOQ (15670 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	3	187141216	187141216	+	IGR	DEL	A	-	-	rs80024997		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:187141216delA								RTP4 (51849 upstream) : SST (245480 downstream)																																			---	---	---	---
RTP2	344892	broad.mit.edu	37	3	187416873	187416873	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:187416873delA	uc003fro.1	-							NM_001004312	NP_001004312			receptor transporting protein 2						protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding				0	all_cancers(143;4.06e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0515)														---	---	---	---
UTS2D	257313	broad.mit.edu	37	3	190992906	190992906	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:190992906delT	uc003fsu.2	-							NM_198152	NP_937795			urotensin 2 domain containing precursor							extracellular region	hormone activity				0	all_cancers(143;1.77e-09)|Ovarian(172;0.103)		LUSC - Lung squamous cell carcinoma(58;2.42e-06)|Lung(62;2.86e-06)	GBM - Glioblastoma multiforme(46;0.000214)														---	---	---	---
OPA1	4976	broad.mit.edu	37	3	193354931	193354931	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:193354931delT	uc003ftm.2	+						OPA1_uc003ftg.2_Intron|OPA1_uc003fth.2_Intron|OPA1_uc003fti.2_Intron|OPA1_uc003ftj.2_Intron|OPA1_uc003ftk.2_Intron|OPA1_uc003ftl.2_Intron|OPA1_uc003ftn.2_Intron	NM_015560	NP_056375			optic atrophy 1 isoform 1						apoptosis|axon transport of mitochondrion|inner mitochondrial membrane organization|mitochondrial fission|mitochondrial fusion|positive regulation of anti-apoptosis|response to stimulus|visual perception	dendrite|integral to membrane|mitochondrial crista|mitochondrial intermembrane space|mitochondrial outer membrane	GTP binding|GTPase activity|magnesium ion binding|protein binding				0	all_cancers(143;9.56e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;9.19e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000162)														---	---	---	---
OPA1	4976	broad.mit.edu	37	3	193360958	193360958	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:193360958delA	uc003ftm.2	+						OPA1_uc003ftg.2_Intron|OPA1_uc003fth.2_Intron|OPA1_uc003fti.2_Intron|OPA1_uc003ftj.2_Intron|OPA1_uc003ftk.2_Intron|OPA1_uc003ftl.2_Intron|OPA1_uc003ftn.2_Intron	NM_015560	NP_056375			optic atrophy 1 isoform 1						apoptosis|axon transport of mitochondrion|inner mitochondrial membrane organization|mitochondrial fission|mitochondrial fusion|positive regulation of anti-apoptosis|response to stimulus|visual perception	dendrite|integral to membrane|mitochondrial crista|mitochondrial intermembrane space|mitochondrial outer membrane	GTP binding|GTPase activity|magnesium ion binding|protein binding				0	all_cancers(143;9.56e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;9.19e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000162)														---	---	---	---
C3orf21	152002	broad.mit.edu	37	3	194947599	194947599	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:194947599delA	uc003fum.3	-						C3orf21_uc011bsw.1_Intron	NM_152531	NP_689744			hypothetical protein LOC152002							integral to membrane	transferase activity, transferring glycosyl groups				0	all_cancers(143;9.33e-09)|Ovarian(172;0.0634)		Epithelial(36;1.73e-20)|all cancers(36;1.42e-18)|OV - Ovarian serous cystadenocarcinoma(49;1.56e-17)|Lung(62;0.000117)|LUSC - Lung squamous cell carcinoma(58;0.000146)	GBM - Glioblastoma multiforme(46;1.36e-05)														---	---	---	---
SDHAP1	255812	broad.mit.edu	37	3	195709193	195709193	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:195709193delA	uc011btq.1	-						SDHAP1_uc003fvx.3_Intron|SDHAP1_uc011btp.1_Intron					SubName: Full=cDNA FLJ56858, highly similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial (EC 1.3.5.1);												0																		---	---	---	---
Unknown	0	broad.mit.edu	37	3	195772161	195772161	+	IGR	DEL	A	-	-	rs76518526		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:195772161delA								SDHAP1 (55011 upstream) : TFRC (3995 downstream)																																			---	---	---	---
TFRC	7037	broad.mit.edu	37	3	195802438	195802438	+	Intron	DEL	T	-	-	rs71949472		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:195802438delT	uc003fvz.3	-						TFRC_uc003fwa.3_Intron|TFRC_uc010hzy.2_Intron|TFRC_uc011btr.1_Intron	NM_003234	NP_003225			transferrin receptor						cellular iron ion homeostasis|endocytosis|interspecies interaction between organisms|proteolysis|transferrin transport|transmembrane transport	coated pit|endosome|integral to plasma membrane|melanosome	peptidase activity|transferrin receptor activity			ovary(3)	3	all_cancers(143;1.94e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.36e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.17e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00233)				T	BCL6	NHL								---	---	---	---
DLG1	1739	broad.mit.edu	37	3	196857450	196857450	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:196857450delT	uc003fxo.3	-	12	1402	c.1212delA	c.(1210-1212)AAAfs	p.K404fs	DLG1_uc011bub.1_Frame_Shift_Del_p.K288fs|DLG1_uc011buc.1_Frame_Shift_Del_p.K288fs|DLG1_uc011bud.1_Frame_Shift_Del_p.K87fs|DLG1_uc003fxn.3_Frame_Shift_Del_p.K404fs|DLG1_uc011bue.1_Frame_Shift_Del_p.K371fs|DLG1_uc010ial.2_Frame_Shift_Del_p.K404fs|DLG1_uc011buf.1_RNA|DLG1_uc003fxp.2_RNA|DLG1_uc010iam.1_Frame_Shift_Del_p.K371fs|DLG1_uc010ian.2_Frame_Shift_Del_p.K271fs	NM_001098424	NP_001091894	Q12959	DLG1_HUMAN	discs, large homolog 1 isoform 1	404	PDZ 2.				actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			ovary(3)	3	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)														---	---	---	---
ZNF732	654254	broad.mit.edu	37	4	264215	264226	+	Intron	DEL	AAAAAAAAAAAA	-	-	rs13110246		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:264215_264226delAAAAAAAAAAAA	uc010ibb.1	-											Homo sapiens chromosome 4 isolate HA_003619 mRNA sequence.						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
PDE6B	5158	broad.mit.edu	37	4	654084	654084	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:654084delG	uc003gap.2	+						PDE6B_uc003gao.3_Intron|PDE6B_uc011buy.1_Intron	NM_000283	NP_000274			phosphodiesterase 6B isoform 1						cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding				0																		---	---	---	---
WHSC1	7468	broad.mit.edu	37	4	1940129	1940129	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:1940129delT	uc003gdz.3	+						WHSC1_uc003geb.3_Intron|WHSC1_uc003gec.3_Intron|WHSC1_uc003ged.3_Intron|WHSC1_uc003gee.3_Intron|WHSC1_uc003gef.3_Intron|WHSC1_uc003gei.3_5'Flank|WHSC1_uc003gdy.1_Intron|WHSC1_uc010icd.1_Intron|WHSC1_uc003gea.1_Intron|WHSC1_uc010ice.1_Intron|WHSC1_uc003geh.1_Intron	NM_001042424	NP_001035889			Wolf-Hirschhorn syndrome candidate 1 protein						anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)				T	IGH@	MM								---	---	---	---
OTOP1	133060	broad.mit.edu	37	4	4199303	4199303	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:4199303delG	uc003ghp.1	-	5	1288	c.1258delC	c.(1258-1260)CGCfs	p.R420fs		NM_177998	NP_819056	Q7RTM1	OTOP1_HUMAN	otopetrin 1	420					biomineral tissue development	extracellular space|integral to membrane				ovary(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)														---	---	---	---
D4S234E	27065	broad.mit.edu	37	4	4411238	4411239	+	Intron	DEL	GT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:4411238_4411239delGT	uc011bvz.1	+						D4S234E_uc011bwa.1_Intron|D4S234E_uc003ghz.2_Intron|D4S234E_uc003gia.2_Intron|D4S234E_uc003gib.2_Intron	NM_014392	NP_055207			brain neuron cytoplasmic protein 1						dopamine receptor signaling pathway	Golgi membrane|integral to membrane|nucleus	dopamine receptor binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.166)														---	---	---	---
EVC	2121	broad.mit.edu	37	4	5750156	5750156	+	Intron	DEL	A	-	-	rs13143108	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:5750156delA	uc003gil.1	+						EVC_uc003gim.1_Intron|CRMP1_uc003gin.1_Intron	NM_153717	NP_714928			Ellis van Creveld syndrome protein						muscle organ development	integral to membrane				ovary(1)|skin(1)	2		Myeloproliferative disorder(84;0.117)																---	---	---	---
CRMP1	1400	broad.mit.edu	37	4	5830500	5830501	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:5830500_5830501insT	uc003gip.2	-						EVC_uc003gim.1_RNA|CRMP1_uc003gin.1_Intron|CRMP1_uc003giq.2_Intron|CRMP1_uc003gir.2_Intron|CRMP1_uc003gis.2_Intron	NM_001313	NP_001304			collapsin response mediator protein 1 isoform 2						axon guidance|pyrimidine base catabolic process	cytosol|microtubule organizing center|spindle	dihydropyrimidinase activity|protein binding			ovary(2)	2				Colorectal(103;0.0721)														---	---	---	---
MRFAP1L1	114932	broad.mit.edu	37	4	6711494	6711494	+	5'UTR	DEL	T	-	-	rs71695362		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:6711494delT	uc003gjn.2	-	1					MRFAP1L1_uc003gjo.2_5'UTR	NM_203462	NP_982287			Morf4 family associated protein 1-like 1												0																		---	---	---	---
CLNK	116449	broad.mit.edu	37	4	10543504	10543504	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:10543504delT	uc003gmo.3	-						CLNK_uc003gmp.2_Intron	NM_052964	NP_443196			mast cell immunoreceptor signal transducer						immune response|intracellular signal transduction	intracellular	SH3/SH2 adaptor activity			ovary(1)	1																		---	---	---	---
FBXL5	26234	broad.mit.edu	37	4	15628685	15628685	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:15628685delA	uc003goc.1	-						FBXL5_uc010idw.1_Intron|FBXL5_uc003gob.1_Intron|FBXL5_uc010idx.1_Intron|FBXL5_uc003god.1_Intron|FBXL5_uc010idy.1_Intron	NM_012161	NP_036293			F-box and leucine-rich repeat protein 5 isoform						iron ion homeostasis|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|SCF ubiquitin ligase complex	iron ion binding|protein binding|ubiquitin-protein ligase activity				0																		---	---	---	---
BST1	683	broad.mit.edu	37	4	15717242	15717242	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:15717242delT	uc003goh.3	+						BST1_uc003goi.2_Intron	NM_004334	NP_004325			bone marrow stromal cell antigen 1 precursor						humoral immune response|multicellular organismal development	anchored to membrane|extrinsic to membrane|plasma membrane	binding|NAD+ nucleosidase activity			central_nervous_system(1)	1																		---	---	---	---
LAP3	51056	broad.mit.edu	37	4	17585226	17585226	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:17585226delA	uc003gph.1	+	5	662	c.500delA	c.(499-501)CAAfs	p.Q167fs	LAP3_uc010ieg.2_3'UTR	NM_015907	NP_056991	P28838	AMPL_HUMAN	leucine aminopeptidase 3	167					proteolysis	nucleus	aminopeptidase activity|magnesium ion binding|manganese ion binding|metalloexopeptidase activity|zinc ion binding				0																		---	---	---	---
NCAPG	64151	broad.mit.edu	37	4	17842015	17842015	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:17842015delT	uc003gpp.2	+						NCAPG_uc011bxj.1_Intron	NM_022346	NP_071741			chromosome condensation protein G						cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	protein binding			large_intestine(1)	1				STAD - Stomach adenocarcinoma(129;0.18)														---	---	---	---
GPR125	166647	broad.mit.edu	37	4	22422868	22422868	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:22422868delA	uc003gqm.1	-						GPR125_uc010ieo.1_Intron|GPR125_uc003gqn.1_Intron|GPR125_uc003gqo.2_Intron	NM_145290	NP_660333			G protein-coupled receptor 125 precursor						neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			skin(1)	1		Breast(46;0.198)																---	---	---	---
GBA3	57733	broad.mit.edu	37	4	22750449	22750449	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:22750449delT	uc003gqp.3	+						GBA3_uc010iep.2_Intron|GBA3_uc011bxo.1_Intron	NM_020973	NP_066024			cytosolic beta-glucosidase isoform a						glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity				0																		---	---	---	---
GBA3	57733	broad.mit.edu	37	4	22820326	22820326	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:22820326delT	uc003gqp.3	+						GBA3_uc010iep.2_Intron|GBA3_uc011bxo.1_Intron	NM_020973	NP_066024			cytosolic beta-glucosidase isoform a						glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity				0																		---	---	---	---
SEL1L3	23231	broad.mit.edu	37	4	25804213	25804213	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:25804213delT	uc003gru.3	-						SEL1L3_uc003grv.2_Intron	NM_015187	NP_056002			sel-1 suppressor of lin-12-like 3							integral to membrane	binding				0																		---	---	---	---
TBC1D19	55296	broad.mit.edu	37	4	26719531	26719531	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:26719531delT	uc003gsf.3	+						TBC1D19_uc010iew.2_Intron|TBC1D19_uc011bxu.1_Intron	NM_018317	NP_060787			TBC1 domain family, member 19							intracellular	Rab GTPase activator activity			breast(1)	1		Breast(46;0.0503)																---	---	---	---
FAM114A1	92689	broad.mit.edu	37	4	38907608	38907608	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:38907608delT	uc003gtn.2	+						FAM114A1_uc011byh.1_Intron	NM_138389	NP_612398			hypothetical protein LOC92689							cytoplasm				ovary(1)	1																		---	---	---	---
RFC1	5981	broad.mit.edu	37	4	39352874	39352894	+	Intron	DEL	AAAAAAAAAAAAAAAAAAAAA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:39352874_39352894delAAAAAAAAAAAAAAAAAAAAA	uc003gty.1	-						RFC1_uc003gtx.1_Intron|RFC1_uc003gtz.1_Intron	NM_002913	NP_002904			replication factor C large subunit						DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|telomere maintenance via telomerase|transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4																		---	---	---	---
SLC30A9	10463	broad.mit.edu	37	4	42077874	42077874	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:42077874delT	uc003gwl.2	+						SLC30A9_uc011byx.1_Intron	NM_006345	NP_006336			solute carrier family 30 (zinc transporter),						nucleotide-excision repair|zinc ion transport	cytoskeleton|integral to membrane|nucleus	cation transmembrane transporter activity|nucleotide binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)	3																		---	---	---	---
SLC30A9	10463	broad.mit.edu	37	4	42080153	42080154	+	Intron	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:42080153_42080154delTT	uc003gwl.2	+						SLC30A9_uc011byx.1_Intron	NM_006345	NP_006336			solute carrier family 30 (zinc transporter),						nucleotide-excision repair|zinc ion transport	cytoskeleton|integral to membrane|nucleus	cation transmembrane transporter activity|nucleotide binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)	3																		---	---	---	---
ATP8A1	10396	broad.mit.edu	37	4	42557888	42557889	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:42557888_42557889insA	uc003gwr.2	-						ATP8A1_uc003gws.2_Intron|ATP8A1_uc011byz.1_Intron	NM_006095	NP_006086			ATPase, aminophospholipid transporter (APLT),						ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			skin(2)|central_nervous_system(1)	3					Phosphatidylserine(DB00144)													---	---	---	---
GABRG1	2565	broad.mit.edu	37	4	46060735	46060735	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:46060735delT	uc003gxb.2	-							NM_173536	NP_775807			gamma-aminobutyric acid A receptor, gamma 1						gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)														---	---	---	---
CORIN	10699	broad.mit.edu	37	4	47644240	47644240	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:47644240delA	uc003gxm.2	-						CORIN_uc011bzf.1_Intron|CORIN_uc011bzg.1_Intron	NM_006587	NP_006578			corin						peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
FRYL	285527	broad.mit.edu	37	4	48564874	48564874	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:48564874delA	uc003gyh.1	-						FRYL_uc003gyk.2_Intron|FRYL_uc003gyi.1_Intron	NM_015030	NP_055845			furry-like						regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1																		---	---	---	---
FRYL	285527	broad.mit.edu	37	4	48578246	48578246	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:48578246delA	uc003gyh.1	-						FRYL_uc003gyk.2_Intron	NM_015030	NP_055845			furry-like						regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1																		---	---	---	---
FRYL	285527	broad.mit.edu	37	4	48597771	48597771	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:48597771delA	uc003gyh.1	-						FRYL_uc003gyk.2_Intron	NM_015030	NP_055845			furry-like						regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1																		---	---	---	---
FRYL	285527	broad.mit.edu	37	4	48625212	48625213	+	Intron	DEL	AC	-	-	rs776579	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:48625212_48625213delAC	uc003gyh.1	-						FRYL_uc003gyk.2_Intron|FRYL_uc003gyl.1_Intron|FRYL_uc003gym.1_Intron	NM_015030	NP_055845			furry-like						regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1																		---	---	---	---
DCUN1D4	23142	broad.mit.edu	37	4	52757912	52757912	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:52757912delT	uc003gze.2	+						DCUN1D4_uc003gzf.2_Intron|DCUN1D4_uc011bzn.1_Intron|DCUN1D4_uc003gzg.2_Intron|DCUN1D4_uc003gzh.2_Intron|DCUN1D4_uc011bzo.1_Intron	NM_001040402	NP_001035492			DCN1, defective in cullin neddylation 1, domain											ovary(2)	2			GBM - Glioblastoma multiforme(4;1.93e-11)|LUSC - Lung squamous cell carcinoma(32;0.00654)															---	---	---	---
SRD5A3	79644	broad.mit.edu	37	4	56217825	56217826	+	Intron	DEL	AA	-	-	rs34820507		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:56217825_56217826delAA	uc003hau.2	+							NM_024592	NP_078868			steroid 5 alpha-reductase 3						androgen biosynthetic process|dolichol metabolic process|dolichol-linked oligosaccharide biosynthetic process|polyprenol catabolic process	endoplasmic reticulum membrane|integral to membrane	3-oxo-5-alpha-steroid 4-dehydrogenase activity|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor				0	all_cancers(7;0.0308)|all_lung(4;0.00195)|Lung NSC(11;0.00431)|all_epithelial(27;0.0425)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.0179)															---	---	---	---
PPAT	5471	broad.mit.edu	37	4	57267248	57267248	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:57267248delA	uc003hbr.2	-							NM_002703	NP_002694			phosphoribosyl pyrophosphate amidotransferase						glutamine metabolic process|nucleoside metabolic process|purine base biosynthetic process|purine ribonucleoside monophosphate biosynthetic process	cytosol	4 iron, 4 sulfur cluster binding|amidophosphoribosyltransferase activity|metal ion binding				0	Glioma(25;0.08)|all_neural(26;0.101)				L-Glutamine(DB00130)|Thioguanine(DB00352)													---	---	---	---
Unknown	0	broad.mit.edu	37	4	57500223	57500223	+	IGR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:57500223delA								ARL9 (110165 upstream) : HOPX (13931 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	4	57576161	57576161	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:57576161delT								HOPX (28289 upstream) : SPINK2 (99873 downstream)																																			---	---	---	---
EPHA5	2044	broad.mit.edu	37	4	66440080	66440080	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:66440080delA	uc003hcy.2	-						EPHA5_uc003hcx.2_Intron|EPHA5_uc003hcz.2_Intron|EPHA5_uc011cah.1_Intron|EPHA5_uc011cai.1_Intron|EPHA5_uc003hda.2_Intron	NM_004439	NP_004430			ephrin receptor EphA5 isoform a precursor						cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24															TSP Lung(17;0.13)			---	---	---	---
TMPRSS11D	9407	broad.mit.edu	37	4	68691613	68691613	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:68691613delA	uc003hdq.2	-						LOC550112_uc003hdl.3_Intron|TMPRSS11D_uc003hdp.2_Intron|TMPRSS11D_uc011caj.1_Intron	NM_004262	NP_004253			transmembrane protease, serine 11D						proteolysis|respiratory gaseous exchange	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1																		---	---	---	---
TMPRSS11D	9407	broad.mit.edu	37	4	68691790	68691790	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:68691790delT	uc003hdq.2	-						LOC550112_uc003hdl.3_Intron|TMPRSS11D_uc003hdp.2_Intron|TMPRSS11D_uc011caj.1_Intron	NM_004262	NP_004253			transmembrane protease, serine 11D						proteolysis|respiratory gaseous exchange	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1																		---	---	---	---
YTHDC1	91746	broad.mit.edu	37	4	69198691	69198692	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:69198691_69198692insA	uc003hdx.2	-						YTHDC1_uc003hdy.2_Intron	NM_001031732	NP_001026902			splicing factor YT521-B isoform 1											upper_aerodigestive_tract(1)|ovary(1)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	4	69433562	69433562	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:69433562delT								YTHDC1 (217738 upstream) : UGT2B15 (78754 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	4	69444612	69444612	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:69444612delT								YTHDC1 (228788 upstream) : UGT2B15 (67704 downstream)																																			---	---	---	---
UGT2B15	7366	broad.mit.edu	37	4	69520703	69520703	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:69520703delT	uc011cal.1	-							NM_001076	NP_001067			UDP glycosyltransferase 2B15 precursor						steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity				0																		---	---	---	---
RUFY3	22902	broad.mit.edu	37	4	71656792	71656792	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:71656792delT	uc003hfq.2	+						RUFY3_uc011cax.1_Intron|RUFY3_uc003hfr.2_Intron|RUFY3_uc011cay.1_Intron	NM_014961	NP_055776			RUN and FYVE domain containing 3 isoform 2						negative regulation of axonogenesis	filopodium|growth cone					0		all_hematologic(202;0.248)	Lung(101;0.235)															---	---	---	---
SLC4A4	8671	broad.mit.edu	37	4	72352882	72352882	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:72352882delA	uc003hfy.2	+						SLC4A4_uc010iic.2_Intron|SLC4A4_uc010iib.2_Intron|SLC4A4_uc003hfz.2_Intron|SLC4A4_uc003hgc.3_Intron|SLC4A4_uc010iid.2_Intron	NM_001098484	NP_001091954			solute carrier family 4, sodium bicarbonate							basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)															---	---	---	---
ADAMTS3	9508	broad.mit.edu	37	4	73184484	73184484	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:73184484delA	uc003hgk.1	-							NM_014243	NP_055058			ADAM metallopeptidase with thrombospondin type 1						collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)															---	---	---	---
ANKRD17	26057	broad.mit.edu	37	4	73963152	73963155	+	Intron	DEL	TTTT	-	-	rs55834843		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:73963152_73963155delTTTT	uc003hgp.2	-						ANKRD17_uc003hgo.2_Intron|ANKRD17_uc003hgq.2_Intron|ANKRD17_uc003hgr.2_Intron	NM_032217	NP_115593			ankyrin repeat domain protein 17 isoform a						interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)															---	---	---	---
ANKRD17	26057	broad.mit.edu	37	4	74010431	74010431	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:74010431delA	uc003hgp.2	-						ANKRD17_uc003hgo.2_Intron|ANKRD17_uc003hgq.2_Intron|ANKRD17_uc003hgr.2_Intron|ANKRD17_uc011cbd.1_Intron	NM_032217	NP_115593			ankyrin repeat domain protein 17 isoform a						interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)															---	---	---	---
ALB	213	broad.mit.edu	37	4	74270303	74270305	+	Intron	DEL	AAA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:74270303_74270305delAAA	uc003hgs.3	+						ALB_uc003hgw.3_Intron|ALB_uc011cbe.1_Intron|ALB_uc003hgt.3_Intron|ALB_uc010iii.2_Intron|ALB_uc003hgu.3_Intron|ALB_uc003hgv.3_Intron|ALB_uc011cbf.1_5'Flank	NM_000477	NP_000468			albumin preproprotein						bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			ovary(3)|skin(3)	6	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin(DB00096)|Serum albumin iodonated(DB00064)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)													---	---	---	---
MTHFD2L	441024	broad.mit.edu	37	4	75167397	75167397	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:75167397delT	uc011cbk.1	+						MTHFD2L_uc003hhu.2_Intron|uc003hhv.1_Intron	NM_001144978	NP_001138450			methylenetetrahydrofolate dehydrogenase 2-like						folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process		binding|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NAD+) activity			ovary(1)|central_nervous_system(1)	2			all cancers(17;0.0101)|Lung(101;0.196)															---	---	---	---
PARM1	25849	broad.mit.edu	37	4	75959192	75959192	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:75959192delA	uc003hih.1	+							NM_015393	NP_056208			prostatic androgen-repressed message-1						positive regulation of telomerase activity	early endosome|endosome membrane|Golgi membrane|integral to membrane|late endosome|plasma membrane				ovary(1)	1																		---	---	---	---
USO1	8615	broad.mit.edu	37	4	76734267	76734267	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:76734267delA	uc003hiu.2	+						USO1_uc003hiv.2_Intron|USO1_uc003hiw.2_Intron	NM_003715	NP_003706			USO1 homolog, vesicle docking protein						intracellular protein transport|vesicle fusion with Golgi apparatus	cytosol|Golgi membrane	protein binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)															---	---	---	---
ART3	419	broad.mit.edu	37	4	76956982	76956982	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:76956982delA	uc003hjk.2	+						ART3_uc003hji.2_Intron|ART3_uc003hjj.2_Intron|CXCL11_uc003hjm.2_Intron	NM_001130017	NP_001123489			ADP-ribosyltransferase 3 isoform c						protein ADP-ribosylation	anchored to membrane|integral to plasma membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity			ovary(2)	2			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)															---	---	---	---
CCNI	10983	broad.mit.edu	37	4	77969240	77969240	+	3'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:77969240delT	uc003hkm.2	-	7					CCNI_uc011ccb.1_3'UTR	NM_006835	NP_006826			cyclin I						spermatogenesis					ovary(1)	1																		---	---	---	---
ANTXR2	118429	broad.mit.edu	37	4	80905931	80905932	+	Intron	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:80905931_80905932delAA	uc003hlz.3	-						ANTXR2_uc003hly.3_Intron|ANTXR2_uc003hlx.1_Intron|ANTXR2_uc010ijn.2_Intron	NM_001145794	NP_001139266			anthrax toxin receptor 2 isoform 2							endoplasmic reticulum membrane|extracellular region|integral to membrane|plasma membrane	metal ion binding|protein binding|receptor activity			ovary(1)	1														Juvenile_Hyaline_Fibromatosis				---	---	---	---
SEC31A	22872	broad.mit.edu	37	4	83784550	83784550	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:83784550delA	uc003hnf.2	-						SEC31A_uc003hne.2_Intron|SEC31A_uc011ccl.1_Intron|SEC31A_uc003hnl.2_Intron|SEC31A_uc003hng.2_Intron|SEC31A_uc003hnh.2_Intron|SEC31A_uc003hni.2_Intron|SEC31A_uc003hnj.2_Intron|SEC31A_uc011ccm.1_Intron|SEC31A_uc011ccn.1_Intron|SEC31A_uc003hnk.2_Intron|SEC31A_uc003hnm.2_Intron|SEC31A_uc003hnn.1_Intron|SEC31A_uc003hno.2_Intron	NM_001077207	NP_001070675			SEC31 homolog A isoform 1						COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/JAK2(4)|SEC31A/ALK(3)	haematopoietic_and_lymphoid_tissue(4)|soft_tissue(3)|breast(1)	8		Hepatocellular(203;0.114)																---	---	---	---
SEC31A	22872	broad.mit.edu	37	4	83785801	83785801	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:83785801delA	uc003hnf.2	-						SEC31A_uc003hne.2_Intron|SEC31A_uc011ccl.1_Intron|SEC31A_uc003hnl.2_Intron|SEC31A_uc003hng.2_Intron|SEC31A_uc003hnh.2_Intron|SEC31A_uc003hni.2_Intron|SEC31A_uc003hnj.2_Intron|SEC31A_uc011ccm.1_Intron|SEC31A_uc011ccn.1_Intron|SEC31A_uc003hnk.2_Intron|SEC31A_uc003hnm.2_Intron|SEC31A_uc003hnn.1_Intron|SEC31A_uc003hno.2_Intron	NM_001077207	NP_001070675			SEC31 homolog A isoform 1						COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/JAK2(4)|SEC31A/ALK(3)	haematopoietic_and_lymphoid_tissue(4)|soft_tissue(3)|breast(1)	8		Hepatocellular(203;0.114)																---	---	---	---
SEC31A	22872	broad.mit.edu	37	4	83792991	83792991	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:83792991delA	uc003hnf.2	-						SEC31A_uc003hne.2_5'UTR|SEC31A_uc011ccl.1_Intron|SEC31A_uc003hnl.2_Intron|SEC31A_uc003hng.2_Intron|SEC31A_uc003hnh.2_Intron|SEC31A_uc003hni.2_Intron|SEC31A_uc003hnj.2_Intron|SEC31A_uc011ccm.1_Intron|SEC31A_uc011ccn.1_Intron|SEC31A_uc003hnk.2_Intron|SEC31A_uc003hnm.2_Intron|SEC31A_uc003hnn.1_Intron|SEC31A_uc003hno.2_Intron	NM_001077207	NP_001070675			SEC31 homolog A isoform 1						COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/JAK2(4)|SEC31A/ALK(3)	haematopoietic_and_lymphoid_tissue(4)|soft_tissue(3)|breast(1)	8		Hepatocellular(203;0.114)																---	---	---	---
COPS4	51138	broad.mit.edu	37	4	83996434	83996434	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:83996434delT	uc003hoa.2	+						COPS4_uc003hob.2_Intron|COPS4_uc010ijw.2_Intron|COPS4_uc010ijx.2_Intron	NM_016129	NP_057213			COP9 signalosome subunit 4						cullin deneddylation	cytoplasm|signalosome	protein binding			kidney(1)	1		Hepatocellular(203;0.114)																---	---	---	---
WDFY3	23001	broad.mit.edu	37	4	85625435	85625435	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:85625435delT	uc003hpd.2	-						WDFY3_uc003hpe.1_Intron	NM_014991	NP_055806			WD repeat and FYVE domain containing 3 isoform							cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)														---	---	---	---
WDFY3	23001	broad.mit.edu	37	4	85630309	85630309	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:85630309delT	uc003hpd.2	-						WDFY3_uc003hpe.1_Intron	NM_014991	NP_055806			WD repeat and FYVE domain containing 3 isoform							cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)														---	---	---	---
WDFY3	23001	broad.mit.edu	37	4	85663139	85663139	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:85663139delA	uc003hpd.2	-							NM_014991	NP_055806			WD repeat and FYVE domain containing 3 isoform							cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)														---	---	---	---
WDFY3	23001	broad.mit.edu	37	4	85718011	85718011	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:85718011delT	uc003hpd.2	-							NM_014991	NP_055806			WD repeat and FYVE domain containing 3 isoform							cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)														---	---	---	---
PTPN13	5783	broad.mit.edu	37	4	87656211	87656212	+	Intron	INS	-	T	T	rs142916492	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:87656211_87656212insT	uc003hpz.2	+						PTPN13_uc003hpy.2_Intron|PTPN13_uc003hqa.2_Intron|PTPN13_uc003hqb.2_Intron	NM_080683	NP_542414			protein tyrosine phosphatase, non-receptor type							cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)														---	---	---	---
PTPN13	5783	broad.mit.edu	37	4	87691032	87691032	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:87691032delA	uc003hpz.2	+	29	5080	c.4600delA	c.(4600-4602)AAAfs	p.K1534fs	PTPN13_uc003hpy.2_Frame_Shift_Del_p.K1539fs|PTPN13_uc003hqa.2_Frame_Shift_Del_p.K1515fs|PTPN13_uc003hqb.2_Frame_Shift_Del_p.K1343fs|PTPN13_uc003hqc.1_5'UTR	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	1534	PDZ 3.					cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)														---	---	---	---
AFF1	4299	broad.mit.edu	37	4	87967812	87967812	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:87967812delT	uc003hqj.3	+						AFF1_uc011ccx.1_Intron|AFF1_uc003hqh.1_Intron|AFF1_uc011ccy.1_Intron|AFF1_uc011ccz.1_Intron|AFF1_uc003hqk.3_Intron|AFF1_uc011cda.1_Intron	NM_005935	NP_005926			myeloid/lymphoid or mixed-lineage leukemia							nucleus	sequence-specific DNA binding transcription factor activity			breast(1)	1		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)														---	---	---	---
AFF1	4299	broad.mit.edu	37	4	88048902	88048902	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:88048902delA	uc003hqj.3	+						AFF1_uc011ccz.1_Intron|AFF1_uc003hqk.3_Intron|AFF1_uc011cda.1_Intron	NM_005935	NP_005926			myeloid/lymphoid or mixed-lineage leukemia							nucleus	sequence-specific DNA binding transcription factor activity			breast(1)	1		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)														---	---	---	---
ABCG2	9429	broad.mit.edu	37	4	89028439	89028439	+	Intron	DEL	A	-	-	rs34485575		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:89028439delA	uc003hrg.2	-						ABCG2_uc003hrh.2_Intron|ABCG2_uc003hrf.2_Intron	NM_004827	NP_004818			ATP-binding cassette, sub-family G, member 2						cellular iron ion homeostasis|urate metabolic process	integral to membrane|plasma membrane	ATP binding|heme transporter activity|protein homodimerization activity|xenobiotic-transporting ATPase activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;7.02e-05)	Imatinib(DB00619)|Mitoxantrone(DB01204)|Nicardipine(DB00622)|Nitrendipine(DB01054)|Rosuvastatin(DB01098)|Saquinavir(DB01232)|Topotecan(DB01030)													---	---	---	---
HERC5	51191	broad.mit.edu	37	4	89389304	89389305	+	Intron	DEL	TA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:89389304_89389305delTA	uc003hrt.2	+						HERC5_uc011cdm.1_Intron	NM_016323	NP_057407			hect domain and RLD 5						innate immune response|ISG15-protein conjugation|negative regulation of type I interferon production|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cyclin-dependent protein kinase activity|regulation of defense response to virus|response to virus	cytosol|perinuclear region of cytoplasm	ISG15 ligase activity|protein binding|ubiquitin-protein ligase activity			ovary(4)|lung(3)|skin(2)	9		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000209)														---	---	---	---
HERC5	51191	broad.mit.edu	37	4	89397280	89397280	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:89397280delT	uc003hrt.2	+						HERC5_uc011cdm.1_Intron	NM_016323	NP_057407			hect domain and RLD 5						innate immune response|ISG15-protein conjugation|negative regulation of type I interferon production|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cyclin-dependent protein kinase activity|regulation of defense response to virus|response to virus	cytosol|perinuclear region of cytoplasm	ISG15 ligase activity|protein binding|ubiquitin-protein ligase activity			ovary(4)|lung(3)|skin(2)	9		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000209)														---	---	---	---
PDLIM5	10611	broad.mit.edu	37	4	95578859	95578859	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:95578859delT	uc003hti.2	+						PDLIM5_uc011cdx.1_Intron|PDLIM5_uc003hth.2_Intron|PDLIM5_uc003htj.2_Intron|PDLIM5_uc003htk.2_Intron|PDLIM5_uc011cdy.1_Intron|PDLIM5_uc003htl.2_Intron	NM_006457	NP_006448			PDZ and LIM domain 5 isoform a						regulation of dendritic spine morphogenesis|regulation of synaptogenesis	actin cytoskeleton|cell junction|cytosol|postsynaptic density|postsynaptic membrane|synaptosome	actin binding|actinin binding|protein kinase C binding|zinc ion binding			ovary(1)|skin(1)	2		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.84e-09)														---	---	---	---
UNC5C	8633	broad.mit.edu	37	4	96199633	96199633	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:96199633delT	uc003htp.1	-						UNC5C_uc010ilc.1_Intron|UNC5C_uc003htq.2_Intron	NM_003728	NP_003719			unc5C precursor						apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)														---	---	---	---
TSPAN5	10098	broad.mit.edu	37	4	99393485	99393485	+	3'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:99393485delT	uc003hub.2	-	8					TSPAN5_uc011cdz.1_3'UTR	NM_005723	NP_005714			transmembrane 4 superfamily member 9							integral to membrane					0				OV - Ovarian serous cystadenocarcinoma(123;1.89e-07)														---	---	---	---
ADH5	128	broad.mit.edu	37	4	100009952	100009953	+	5'Flank	INS	-	G	G	rs145470085	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:100009952_100009953insG	uc003hui.2	-						ADH5_uc003huk.1_5'Flank|uc003hum.1_5'Flank|uc003hul.1_5'Flank	NM_000671	NP_000662			class III alcohol dehydrogenase, chi subunit						ethanol oxidation|response to redox state		alcohol dehydrogenase (NAD) activity|electron carrier activity|fatty acid binding|formaldehyde dehydrogenase activity|S-(hydroxymethyl)glutathione dehydrogenase activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;2.5e-07)	NADH(DB00157)													---	---	---	---
ADH6	130	broad.mit.edu	37	4	100128480	100128480	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:100128480delA	uc003hup.3	-						uc003hum.1_Intron|ADH6_uc003huo.2_Intron|ADH6_uc011cef.1_Intron|ADH6_uc010ile.2_Intron	NM_000672	NP_000663			class V alcohol dehydrogenase isoform 2						ethanol oxidation|response to ethanol|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|electron carrier activity|zinc ion binding			ovary(1)|kidney(1)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(123;3.58e-08)	Abacavir(DB01048)|NADH(DB00157)													---	---	---	---
ADH6	130	broad.mit.edu	37	4	100137214	100137214	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:100137214delT	uc003hup.3	-						uc003hum.1_Intron|ADH6_uc003huo.2_Intron|ADH6_uc011cef.1_Intron|ADH6_uc010ile.2_Intron	NM_000672	NP_000663			class V alcohol dehydrogenase isoform 2						ethanol oxidation|response to ethanol|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|electron carrier activity|zinc ion binding			ovary(1)|kidney(1)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(123;3.58e-08)	Abacavir(DB01048)|NADH(DB00157)													---	---	---	---
ADH1A	124	broad.mit.edu	37	4	100200890	100200890	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:100200890delA	uc003hur.1	-						uc003hum.1_Intron|ADH1A_uc011ceg.1_Intron	NM_000667	NP_000658			class I alcohol dehydrogenase, alpha subunit						ethanol oxidation|transcription, DNA-dependent|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|protein binding|zinc ion binding			large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(123;9.56e-08)	Fomepizole(DB01213)|NADH(DB00157)													---	---	---	---
C4orf17	84103	broad.mit.edu	37	4	100443633	100443633	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:100443633delT	uc003huw.2	+						C4orf17_uc003hux.2_Intron	NM_032149	NP_115525			hypothetical protein LOC84103												0				OV - Ovarian serous cystadenocarcinoma(123;2.08e-08)														---	---	---	---
PPP3CA	5530	broad.mit.edu	37	4	101984180	101984180	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:101984180delT	uc011cen.1	-						PPP3CA_uc003hvu.2_Intron|PPP3CA_uc010ilj.2_Intron|PPP3CA_uc003hvt.2_Intron|PPP3CA_uc003hvs.2_Intron|PPP3CA_uc010ilk.2_Intron	NM_000944	NP_000935			protein phosphatase 3, catalytic subunit, alpha						protein dephosphorylation	calcineurin complex|cytosol|nucleus	calcium ion binding|calmodulin binding			ovary(1)|skin(1)	2				OV - Ovarian serous cystadenocarcinoma(123;6.79e-08)														---	---	---	---
BANK1	55024	broad.mit.edu	37	4	102981170	102981170	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:102981170delT	uc003hvy.3	+						BANK1_uc003hvx.3_Intron|BANK1_uc010ill.2_Intron|BANK1_uc003hvz.3_Intron	NM_017935	NP_060405			B-cell scaffold protein with ankyrin repeats 1						B cell activation					ovary(2)|skin(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)														---	---	---	---
MANBA	4126	broad.mit.edu	37	4	103645126	103645127	+	Splice_Site	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:103645126_103645127insA	uc003hwg.2	-	3	373	c.273_splice	c.e3-1	p.S91_splice	MANBA_uc011ces.1_Splice_Site_p.S91_splice	NM_005908	NP_005899			mannosidase, beta A, lysosomal precursor						carbohydrate metabolic process|protein modification process	lysosome	beta-mannosidase activity|cation binding			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;4.44e-08)														---	---	---	---
PPA2	27068	broad.mit.edu	37	4	106317313	106317313	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:106317313delA	uc003hxl.2	-						PPA2_uc003hxm.2_Intron|PPA2_uc003hxn.2_Intron|PPA2_uc003hxo.2_Intron|PPA2_uc003hxp.2_Intron|PPA2_uc003hxq.2_Intron|PPA2_uc003hxr.2_Intron	NM_176869	NP_789845			inorganic pyrophosphatase 2 isoform 1 precursor						diphosphate metabolic process|tRNA aminoacylation for protein translation	mitochondrial matrix	inorganic diphosphatase activity|magnesium ion binding			pancreas(1)	1		Myeloproliferative disorder(5;0.0255)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.03e-07)														---	---	---	---
ARHGEF38	54848	broad.mit.edu	37	4	106552376	106552376	+	3'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:106552376delT	uc003hxu.2	+	4						NM_017700	NP_060170			hypothetical protein LOC54848						regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|breast(1)	3																		---	---	---	---
TBCK	93627	broad.mit.edu	37	4	107037554	107037555	+	Intron	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:107037554_107037555delAA	uc010ilv.2	-						TBCK_uc003hyb.2_Intron|TBCK_uc003hye.2_Intron|TBCK_uc003hyc.2_Intron|TBCK_uc003hyd.2_Intron|TBCK_uc003hyf.2_Intron	NM_001163435	NP_001156907			TBC domain-containing protein kinase-like							intracellular	Rab GTPase activator activity			large_intestine(2)|upper_aerodigestive_tract(1)|stomach(1)|ovary(1)	5																		---	---	---	---
Unknown	0	broad.mit.edu	37	4	113451679	113451680	+	IGR	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:113451679_113451680insT								NEUROG2 (14351 upstream) : C4orf21 (8810 downstream)																																			---	---	---	---
LARP7	51574	broad.mit.edu	37	4	113570754	113570754	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:113570754delA	uc003iay.2	+	9	1484	c.1206delA	c.(1204-1206)TTAfs	p.L402fs	LARP7_uc003iaz.2_Frame_Shift_Del_p.L409fs|LARP7_uc003iba.2_Frame_Shift_Del_p.L323fs|LARP7_uc003ibb.2_Frame_Shift_Del_p.L402fs|uc011cfy.1_5'Flank|MIR367_hsa-mir-367|MI0000775_5'Flank|MIR302D_hsa-mir-302d|MI0000774_5'Flank|uc011cfz.1_5'Flank|MIR302A_hsa-mir-302a|MI0000738_5'Flank|MIR302C_hsa-mir-302c|MI0000773_5'Flank|MIR302B_hsa-mir-302b|MI0000772_5'Flank|uc011cga.1_5'Flank	NM_016648	NP_057732	Q4G0J3	LARP7_HUMAN	La ribonucleoprotein domain family, member 7	402					RNA processing	nucleoplasm|ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(3)	3		Ovarian(17;0.0443)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000603)														---	---	---	---
ANK2	287	broad.mit.edu	37	4	114117645	114117646	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:114117645_114117646insT	uc003ibe.3	+						ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc003ibc.2_Intron|ANK2_uc011cgb.1_Intron	NM_001148	NP_001139			ankyrin 2 isoform 1						axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)														---	---	---	---
ANK2	287	broad.mit.edu	37	4	114199851	114199851	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:114199851delT	uc003ibe.3	+						ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc003ibc.2_Intron|ANK2_uc011cgb.1_Intron	NM_001148	NP_001139			ankyrin 2 isoform 1						axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)												OREG0016024	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
ANK2	287	broad.mit.edu	37	4	114289147	114289147	+	Intron	DEL	A	-	-	rs55966162	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:114289147delA	uc003ibe.3	+						ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Intron	NM_001148	NP_001139			ankyrin 2 isoform 1						axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)														---	---	---	---
NDST4	64579	broad.mit.edu	37	4	115858465	115858466	+	Intron	DEL	TG	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:115858465_115858466delTG	uc003ibu.2	-						NDST4_uc010imw.2_Intron	NM_022569	NP_072091			heparan sulfate N-deacetylase/N-sulfotransferase							Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)														---	---	---	---
METTL14	57721	broad.mit.edu	37	4	119621927	119621927	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:119621927delA	uc003icf.2	+						METTL14_uc003icg.2_Intron	NM_020961	NP_066012			methyltransferase like 14							nucleus	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity				0																		---	---	---	---
MAD2L1	4085	broad.mit.edu	37	4	120981111	120981111	+	3'UTR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:120981111delA	uc003idl.2	-	5					MAD2L1_uc003idm.2_3'UTR	NM_002358	NP_002349			MAD2-like 1						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of apoptosis|negative regulation of mitotic anaphase-promoting complex activity|positive regulation of mitotic cell cycle spindle assembly checkpoint	condensed chromosome kinetochore|cytosol|nucleus|perinuclear region of cytoplasm	protein homodimerization activity				0																		---	---	---	---
PRDM5	11107	broad.mit.edu	37	4	121742611	121742611	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:121742611delT	uc003idn.2	-						PRDM5_uc003ido.2_Intron|PRDM5_uc010ine.2_Intron|PRDM5_uc010inf.2_Intron	NM_018699	NP_061169			PR domain containing 5						histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2																		---	---	---	---
BBS7	55212	broad.mit.edu	37	4	122765171	122765171	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:122765171delA	uc003ied.2	-						BBS7_uc003iee.1_Intron	NM_176824	NP_789794			Bardet-Biedl syndrome 7 protein isoform a						cilium morphogenesis|digestive tract morphogenesis|fat cell differentiation|heart looping|melanosome transport|pigment granule aggregation in cell center|response to stimulus|visual perception	BBSome|centrosome|cilium membrane	protein binding			ovary(1)	1														Bardet-Biedl_syndrome				---	---	---	---
SPATA5	166378	broad.mit.edu	37	4	124235282	124235282	+	3'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:124235282delT	uc003iez.3	+	16						NM_145207	NP_660208			spermatogenesis associated 5						cell differentiation|multicellular organismal development|spermatogenesis	mitochondrion	ATP binding|nucleoside-triphosphatase activity				0																		---	---	---	---
ELF2	1998	broad.mit.edu	37	4	139983329	139983330	+	Intron	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:139983329_139983330delTT	uc003ihp.1	-						ELF2_uc003ihm.1_Intron|ELF2_uc003ihn.1_Intron|ELF2_uc003iho.1_Intron|ELF2_uc011chc.1_5'UTR	NM_201999	NP_973728			E74-like factor 2 (ets domain transcription						negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2	all_hematologic(180;0.162)																	---	---	---	---
TBC1D9	23158	broad.mit.edu	37	4	141545667	141545667	+	Intron	DEL	A	-	-	rs11307081		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:141545667delA	uc010ioj.2	-							NM_015130	NP_055945			TBC1 domain family, member 9 (with GRAM domain)							intracellular	calcium ion binding|Rab GTPase activator activity			ovary(1)	1	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)																---	---	---	---
GAB1	2549	broad.mit.edu	37	4	144381841	144381841	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:144381841delA	uc003ije.2	+						GAB1_uc003ijd.2_Intron|GAB1_uc011chq.1_Intron	NM_002039	NP_002030			GRB2-associated binding protein 1 isoform b						cell proliferation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			breast(2)|lung(1)|skin(1)	4	all_hematologic(180;0.158)																	---	---	---	---
ZNF827	152485	broad.mit.edu	37	4	146700596	146700596	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:146700596delA	uc003ikn.2	-	9	2499	c.2451delT	c.(2449-2451)TTTfs	p.F817fs	ZNF827_uc003ikm.2_Frame_Shift_Del_p.F817fs|ZNF827_uc010iox.2_Frame_Shift_Del_p.F467fs|ZNF827_uc003ikl.2_5'UTR	NM_178835	NP_849157	Q17R98	ZN827_HUMAN	zinc finger protein 827	817	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_hematologic(180;0.151)																	---	---	---	---
TMEM184C	55751	broad.mit.edu	37	4	148553970	148553970	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:148553970delT	uc003ila.3	+							NM_018241	NP_060711			transmembrane protein 184C							integral to membrane					0																		---	---	---	---
PRMT10	90826	broad.mit.edu	37	4	148564097	148564097	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:148564097delA	uc003ilc.2	-						PRMT10_uc003ilb.2_Intron|PRMT10_uc003ild.2_Intron	NM_138364	NP_612373			protein arginine methyltransferase 10							cytoplasm	binding|protein methyltransferase activity			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
PRMT10	90826	broad.mit.edu	37	4	148578868	148578868	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:148578868delT	uc003ilc.2	-						PRMT10_uc003ilb.2_Intron|PRMT10_uc003ild.2_Intron	NM_138364	NP_612373			protein arginine methyltransferase 10							cytoplasm	binding|protein methyltransferase activity			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
NR3C2	4306	broad.mit.edu	37	4	149356231	149356231	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:149356231delA	uc003ilj.3	-						NR3C2_uc003ilk.3_Intron|NR3C2_uc010iph.2_Intron	NM_000901	NP_000892			nuclear receptor subfamily 3, group C, member 2						regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			large_intestine(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)													---	---	---	---
SH3D19	152503	broad.mit.edu	37	4	152048936	152048936	+	Intron	DEL	A	-	-	rs11099782	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:152048936delA	uc010ipl.1	-						SH3D19_uc003imb.2_Intron|SH3D19_uc003imc.2_Intron|SH3D19_uc003ime.2_Intron|SH3D19_uc010ipm.2_Intron	NM_001009555	NP_001009555			SH3 domain containing 19 isoform a						cellular membrane organization|positive regulation of membrane protein ectodomain proteolysis|post-Golgi vesicle-mediated transport	cytosol|Golgi apparatus|nucleus|plasma membrane	proline-rich region binding			ovary(1)|skin(1)	2	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.138)																---	---	---	---
GLRB	2743	broad.mit.edu	37	4	158064828	158064828	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:158064828delT	uc003ipj.2	+							NM_000824	NP_000815			glycine receptor, beta isoform A precursor						nervous system development|neuropeptide signaling pathway|startle response	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|protein binding|receptor activity			skin(2)	2	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0564)|COAD - Colon adenocarcinoma(41;0.0642)|Kidney(143;0.0707)	Glycine(DB00145)													---	---	---	---
RAPGEF2	9693	broad.mit.edu	37	4	160251233	160251234	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:160251233_160251234insT	uc003iqg.3	+							NM_014247	NP_055062			Rap guanine nucleotide exchange factor 2						cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			lung(2)|upper_aerodigestive_tract(1)|skin(1)	4	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)														---	---	---	---
RAPGEF2	9693	broad.mit.edu	37	4	160251797	160251797	+	Intron	DEL	A	-	-	rs78225051		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:160251797delA	uc003iqg.3	+							NM_014247	NP_055062			Rap guanine nucleotide exchange factor 2						cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			lung(2)|upper_aerodigestive_tract(1)|skin(1)	4	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)														---	---	---	---
C4orf43	55319	broad.mit.edu	37	4	164435265	164435265	+	Frame_Shift_Del	DEL	A	-	-	rs2304802	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:164435265delA	uc003iqq.3	+	4	475	c.194delA	c.(193-195)CAAfs	p.Q65fs		NM_018352	NP_060822	Q96EY4	CD043_HUMAN	hypothetical protein LOC55319	65											0																		---	---	---	---
CPE	1363	broad.mit.edu	37	4	166405464	166405464	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:166405464delA	uc003irg.3	+							NM_001873	NP_001864			carboxypeptidase E preproprotein						cardiac left ventricle morphogenesis|neuropeptide signaling pathway|protein modification process	extracellular region|nucleus|plasma membrane	metallocarboxypeptidase activity|protein binding|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3	all_hematologic(180;0.221)	Prostate(90;0.0962)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.137)	Glucagon recombinant(DB00040)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)													---	---	---	---
TLL1	7092	broad.mit.edu	37	4	166987166	166987166	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:166987166delT	uc003irh.1	+						TLL1_uc011cjn.1_Intron|TLL1_uc011cjo.1_Intron	NM_012464	NP_036596			tolloid-like 1 precursor						cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)														---	---	---	---
SPOCK3	50859	broad.mit.edu	37	4	167983738	167983738	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:167983738delA	uc003iri.1	-						SPOCK3_uc011cjp.1_Intron|SPOCK3_uc011cjq.1_Intron|SPOCK3_uc011cjr.1_Intron|SPOCK3_uc003irj.1_Intron|SPOCK3_uc011cjs.1_Intron|SPOCK3_uc011cjt.1_Intron|SPOCK3_uc011cju.1_Intron|SPOCK3_uc011cjv.1_Intron|SPOCK3_uc003irk.3_Intron|SPOCK3_uc011cjw.1_Intron	NM_016950	NP_058646			testican 3 isoform 2						signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)														---	---	---	---
DDX60	55601	broad.mit.edu	37	4	169142737	169142737	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:169142737delA	uc003irp.2	-						DDX60_uc003iro.2_Intron	NM_017631	NP_060101			DEAD (Asp-Glu-Ala-Asp) box polypeptide 60								ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)														---	---	---	---
WWC2	80014	broad.mit.edu	37	4	184114633	184114633	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:184114633delT	uc010irx.2	+						WWC2_uc003ivk.3_5'Flank	NM_024949	NP_079225			WW and C2 domain containing 2											ovary(2)|lung(1)	3		all_lung(41;5.28e-14)|Lung NSC(41;1.35e-13)|Colorectal(36;0.00681)|Hepatocellular(41;0.00886)|Renal(120;0.00992)|Prostate(90;0.0237)|all_hematologic(60;0.0592)|Esophageal squamous(56;0.179)|all_neural(102;0.202)		all cancers(43;3.38e-24)|Epithelial(43;1.4e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.09e-09)|GBM - Glioblastoma multiforme(59;3.33e-05)|Colorectal(24;3.58e-05)|STAD - Stomach adenocarcinoma(60;4.21e-05)|COAD - Colon adenocarcinoma(29;0.000171)|LUSC - Lung squamous cell carcinoma(40;0.0145)|READ - Rectum adenocarcinoma(43;0.242)														---	---	---	---
RWDD4A	201965	broad.mit.edu	37	4	184562626	184562626	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:184562626delA	uc003ivt.1	-							NM_152682	NP_689895			RWD domain containing 4A												0		all_lung(41;4.4e-14)|Lung NSC(41;1.03e-13)|Colorectal(36;0.00139)|all_hematologic(60;0.00756)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.202)		all cancers(43;7.35e-27)|Epithelial(43;1.49e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.76e-10)|GBM - Glioblastoma multiforme(59;5.54e-06)|Colorectal(24;7.92e-06)|STAD - Stomach adenocarcinoma(60;2.35e-05)|COAD - Colon adenocarcinoma(29;6.26e-05)|LUSC - Lung squamous cell carcinoma(40;0.00935)|READ - Rectum adenocarcinoma(43;0.166)														---	---	---	---
CCDC111	201973	broad.mit.edu	37	4	185599680	185599685	+	Intron	DEL	TTTTTT	-	-	rs34520412		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:185599680_185599685delTTTTTT	uc003iwk.2	+						CCDC111_uc003iwj.2_Intron|CCDC111_uc003iwl.2_Intron|CCDC111_uc003iwm.2_Intron|CCDC111_uc003iwn.2_Intron	NM_152683	NP_689896			coiled-coil domain containing 111						DNA replication, synthesis of RNA primer		DNA primase activity			central_nervous_system(1)	1		all_lung(41;9.65e-12)|Lung NSC(41;1.64e-11)|Colorectal(36;0.00531)|Hepatocellular(41;0.00932)|Renal(120;0.0246)|Prostate(90;0.0283)|all_hematologic(60;0.0749)|all_neural(102;0.131)		all cancers(43;5.84e-27)|Epithelial(43;2.2e-23)|OV - Ovarian serous cystadenocarcinoma(60;4.28e-11)|STAD - Stomach adenocarcinoma(60;2.66e-05)|GBM - Glioblastoma multiforme(59;3.03e-05)|Colorectal(24;7.57e-05)|BRCA - Breast invasive adenocarcinoma(30;0.000249)|COAD - Colon adenocarcinoma(29;0.000502)|LUSC - Lung squamous cell carcinoma(40;0.00995)|READ - Rectum adenocarcinoma(43;0.173)														---	---	---	---
ACSL1	2180	broad.mit.edu	37	4	185689743	185689743	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:185689743delA	uc003iww.2	-						ACSL1_uc011ckm.1_Intron|ACSL1_uc003iwt.1_Intron|ACSL1_uc003iwu.1_Intron|ACSL1_uc011ckn.1_Intron|ACSL1_uc003iwv.1_Intron|ACSL1_uc003iws.1_5'Flank|ACSL1_uc010ise.1_Intron	NM_001995	NP_001986			acyl-CoA synthetase long-chain family member 1						digestion|fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|regulation of fatty acid oxidation|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			ovary(2)	2		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00172)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0315)|all_neural(102;0.107)|Medulloblastoma(177;0.146)		all cancers(43;1.33e-28)|Epithelial(43;5.3e-25)|OV - Ovarian serous cystadenocarcinoma(60;4.88e-11)|Colorectal(24;3.59e-06)|STAD - Stomach adenocarcinoma(60;2.72e-05)|GBM - Glioblastoma multiforme(59;2.83e-05)|BRCA - Breast invasive adenocarcinoma(30;7.66e-05)|COAD - Colon adenocarcinoma(29;0.000538)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.0419)	Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)													---	---	---	---
SNX25	83891	broad.mit.edu	37	4	186283364	186283364	+	Intron	DEL	A	-	-	rs78356496		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:186283364delA	uc003ixh.2	+						SNX25_uc010ish.2_Intron|SNX25_uc003ixi.2_Intron	NM_031953	NP_114159			sorting nexin 25						cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			ovary(2)|breast(2)|pancreas(1)	5		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)														---	---	---	---
UFSP2	55325	broad.mit.edu	37	4	186336370	186336370	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:186336370delT	uc003ixo.2	-	6	740	c.623delA	c.(622-624)AATfs	p.N208fs	UFSP2_uc003ixn.2_Frame_Shift_Del_p.N98fs|UFSP2_uc003ixq.2_Frame_Shift_Del_p.N98fs|UFSP2_uc003ixp.2_RNA	NM_018359	NP_060829	Q9NUQ7	UFSP2_HUMAN	UFM1-specific peptidase 2	208						endoplasmic reticulum|nucleus	small conjugating protein-specific protease activity				0		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;0.00109)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;3.4e-25)|Epithelial(43;2.23e-22)|OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;8.1e-05)|GBM - Glioblastoma multiforme(59;0.000148)|STAD - Stomach adenocarcinoma(60;0.000782)|LUSC - Lung squamous cell carcinoma(40;0.00939)|COAD - Colon adenocarcinoma(29;0.0108)|READ - Rectum adenocarcinoma(43;0.166)														---	---	---	---
SORBS2	8470	broad.mit.edu	37	4	186515044	186515044	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:186515044delC	uc003iyl.2	-	19	3988	c.3130delG	c.(3130-3132)GAAfs	p.E1044fs	SORBS2_uc003iyh.2_Frame_Shift_Del_p.E768fs|SORBS2_uc011ckw.1_Frame_Shift_Del_p.E605fs|SORBS2_uc003iyi.2_Frame_Shift_Del_p.E675fs|SORBS2_uc011ckx.1_Frame_Shift_Del_p.E610fs|SORBS2_uc003iyk.2_Frame_Shift_Del_p.E588fs|SORBS2_uc003iym.2_Frame_Shift_Del_p.E1144fs|SORBS2_uc003iyn.1_Frame_Shift_Del_p.E635fs|SORBS2_uc011cku.1_Frame_Shift_Del_p.E436fs|SORBS2_uc011ckv.1_Frame_Shift_Del_p.E948fs|SORBS2_uc003iyd.2_Frame_Shift_Del_p.E743fs|SORBS2_uc003iye.2_Frame_Shift_Del_p.E617fs|SORBS2_uc003iya.2_Frame_Shift_Del_p.E564fs|SORBS2_uc003iyb.2_Frame_Shift_Del_p.E517fs|SORBS2_uc003iyc.2_Frame_Shift_Del_p.E497fs|SORBS2_uc003iyg.2_Frame_Shift_Del_p.E1158fs|SORBS2_uc003iyf.2_Frame_Shift_Del_p.E580fs	NM_021069	NP_066547	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2 isoform 2	1044	SH3 3.					actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)														---	---	---	---
TLR3	7098	broad.mit.edu	37	4	187005786	187005786	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:187005786delT	uc003iyq.2	+						TLR3_uc011ckz.1_Intron|TLR3_uc003iyr.2_Intron	NM_003265	NP_003256			toll-like receptor 3 precursor						activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			ovary(2)|prostate(1)|lung(1)|breast(1)	5		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)														---	---	---	---
FAT1	2195	broad.mit.edu	37	4	187530579	187530579	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:187530579delT	uc003izf.2	-							NM_005245	NP_005236			FAT tumor suppressor 1 precursor						actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12															HNSCC(5;0.00058)			---	---	---	---
Unknown	0	broad.mit.edu	37	4	189309990	189309990	+	IGR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:189309990delA								TRIML1 (241341 upstream) : None (None downstream)																																			---	---	---	---
PLEKHG4B	153478	broad.mit.edu	37	5	171386	171386	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:171386delG	uc003jak.2	+	14	2859	c.2809delG	c.(2809-2811)GTGfs	p.V937fs		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	937	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)														---	---	---	---
LRRC14B	389257	broad.mit.edu	37	5	191707	191707	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:191707delC	uc003jal.1	+	1	82	c.54delC	c.(52-54)CACfs	p.H18fs		NM_001080478	NP_001073947	A6NHZ5	LR14B_HUMAN	leucine rich repeat containing 14B	18										skin(1)	1																		---	---	---	---
KIAA0947	23379	broad.mit.edu	37	5	5476216	5476216	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:5476216delT	uc003jdm.3	+							NM_015325	NP_056140			hypothetical protein LOC23379											ovary(1)|central_nervous_system(1)	2																		---	---	---	---
NSUN2	54888	broad.mit.edu	37	5	6625789	6625789	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:6625789delA	uc003jdu.2	-						NSUN2_uc011cmk.1_Intron|NSUN2_uc003jdv.2_Intron	NM_017755	NP_060225			NOL1/NOP2/Sun domain family, member 2							cytoplasm|nucleolus	tRNA (cytosine-5-)-methyltransferase activity|tRNA binding			ovary(1)	1																		---	---	---	---
FASTKD3	79072	broad.mit.edu	37	5	7861239	7861239	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:7861239delA	uc003jeb.2	-						FASTKD3_uc011cmp.1_Intron|FASTKD3_uc003jec.2_Intron	NM_024091	NP_076996			FAST kinase domains 3						apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(2)|breast(1)|pancreas(1)	4																		---	---	---	---
MTRR	4552	broad.mit.edu	37	5	7885676	7885676	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:7885676delT	uc003jed.2	+						MTRR_uc010itn.1_Intron|MTRR_uc003jee.3_Intron|MTRR_uc003jef.3_Intron|MTRR_uc003jeg.3_Intron|MTRR_uc010ito.2_Intron	NM_024010	NP_076915			methionine synthase reductase isoform 2						methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			ovary(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)													---	---	---	---
CTNND2	1501	broad.mit.edu	37	5	11384949	11384949	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:11384949delG	uc003jfa.1	-	7	1150	c.1005delC	c.(1003-1005)CCCfs	p.P335fs	CTNND2_uc010itt.2_Frame_Shift_Del_p.P244fs|CTNND2_uc011cmy.1_Intron|CTNND2_uc011cmz.1_Intron|CTNND2_uc010itu.1_Intron|CTNND2_uc011cmx.1_5'UTR	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	335					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8																		---	---	---	---
DNAH5	1767	broad.mit.edu	37	5	13708058	13708059	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:13708058_13708059insA	uc003jfd.2	-						DNAH5_uc003jfc.2_Intron	NM_001369	NP_001360			dynein, axonemal, heavy chain 5						microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)													Kartagener_syndrome				---	---	---	---
Unknown	0	broad.mit.edu	37	5	17333068	17333068	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:17333068delT								BASP1 (56133 upstream) : None (None downstream)																																			---	---	---	---
RNASEN	29102	broad.mit.edu	37	5	31508943	31508945	+	Intron	DEL	TTC	-	-	rs72531140	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:31508943_31508945delTTC	uc003jhg.2	-						RNASEN_uc003jhh.2_Intron|RNASEN_uc003jhi.2_Intron|RNASEN_uc010iui.1_Intron	NM_013235	NP_037367			ribonuclease III, nuclear isoform 1						gene silencing by RNA|ribosome biogenesis|RNA processing	nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity				0																		---	---	---	---
MTMR12	54545	broad.mit.edu	37	5	32235098	32235100	+	In_Frame_Del	DEL	GAA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:32235098_32235100delGAA	uc003jhq.2	-	14	1650_1652	c.1480_1482delTTC	c.(1480-1482)TTCdel	p.F494del	MTMR12_uc010iuk.2_In_Frame_Del_p.F494del|MTMR12_uc010iul.2_Intron	NM_001040446	NP_001035536	Q9C0I1	MTMRC_HUMAN	myotubularin related protein 12	494	Myotubularin phosphatase.|Interaction with MTM1.					cytoplasm	phosphatase activity			ovary(1)	1																		---	---	---	---
IL7R	3575	broad.mit.edu	37	5	35867541	35867541	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:35867541delA	uc003jjs.2	+	3	444	c.355delA	c.(355-357)AAAfs	p.K119fs	IL7R_uc011coo.1_Frame_Shift_Del_p.K119fs|IL7R_uc011cop.1_RNA	NM_002185	NP_002176	P16871	IL7RA_HUMAN	interleukin 7 receptor precursor	119	Extracellular (Potential).				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			ovary(3)|breast(1)|skin(1)	5	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)															---	---	---	---
UGT3A2	167127	broad.mit.edu	37	5	36049529	36049530	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:36049529_36049530insA	uc003jjz.1	-						UGT3A2_uc011cos.1_Intron|UGT3A2_uc011cot.1_Intron	NM_174914	NP_777574			UDP glycosyltransferase 3 family, polypeptide A2							integral to membrane	glucuronosyltransferase activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)															---	---	---	---
C5orf42	65250	broad.mit.edu	37	5	37180363	37180363	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:37180363delT	uc011cpa.1	-						C5orf42_uc011coy.1_Intron|C5orf42_uc003jks.2_Intron|C5orf42_uc011coz.1_Intron	NM_023073	NP_075561			hypothetical protein LOC65250											ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)															---	---	---	---
NUP155	9631	broad.mit.edu	37	5	37342847	37342847	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:37342847delT	uc003jku.1	-						NUP155_uc003jkt.1_Intron|NUP155_uc010iuz.1_Intron	NM_153485	NP_705618			nucleoporin 155kDa isoform 1						carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			ovary(1)	1	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)															---	---	---	---
WDR70	55100	broad.mit.edu	37	5	37701133	37701133	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:37701133delT	uc003jkv.2	+							NM_018034	NP_060504			WD repeat domain 70											ovary(1)|central_nervous_system(1)	2	all_lung(31;0.000285)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)															---	---	---	---
OSMR	9180	broad.mit.edu	37	5	38903971	38903971	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:38903971delT	uc003jln.1	+							NM_003999	NP_003990			oncostatin M receptor precursor						cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_lung(31;0.000365)																	---	---	---	---
OSMR	9180	broad.mit.edu	37	5	38904310	38904310	+	Intron	DEL	T	-	-	rs111373045		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:38904310delT	uc003jln.1	+							NM_003999	NP_003990			oncostatin M receptor precursor						cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_lung(31;0.000365)																	---	---	---	---
HEATR7B2	133558	broad.mit.edu	37	5	41039052	41039052	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:41039052delT	uc003jmj.3	-						HEATR7B2_uc003jmi.3_Intron	NM_173489	NP_775760			HEAT repeat family member 7B2								binding			ovary(6)|central_nervous_system(2)	8																		---	---	---	---
GHR	2690	broad.mit.edu	37	5	42699752	42699752	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:42699752delA	uc003jmt.2	+						GHR_uc011cpq.1_Intron	NM_000163	NP_000154			growth hormone receptor precursor						2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			lung(4)|kidney(1)|skin(1)	6		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)													---	---	---	---
CCDC152	100129792	broad.mit.edu	37	5	42800579	42800579	+	3'UTR	DEL	A	-	-	rs71793261		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:42800579delA	uc003jmx.3	+	9					CCDC152_uc011cpr.1_3'UTR|SEPP1_uc011cps.1_RNA|SEPP1_uc011cpt.1_RNA|SEPP1_uc011cpu.1_RNA|SEPP1_uc011cpv.1_RNA|SEPP1_uc003jna.2_RNA	NM_001134848	NP_001128320			coiled-coil domain containing 152												0																		---	---	---	---
MGC42105	167359	broad.mit.edu	37	5	43232226	43232226	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:43232226delG	uc003jno.2	+							NM_153361	NP_699192			serine/threonine-protein kinase NIM1								ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|stomach(1)|large_intestine(1)|breast(1)	9																		---	---	---	---
PARP8	79668	broad.mit.edu	37	5	49963703	49963703	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:49963703delG	uc003jon.3	+						PARP8_uc011cpz.1_Intron|PARP8_uc003joo.2_Intron|PARP8_uc003jop.2_Intron	NM_024615	NP_078891			poly (ADP-ribose) polymerase family, member 8							intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)																---	---	---	---
PARP8	79668	broad.mit.edu	37	5	50045918	50045918	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:50045918delT	uc003jon.3	+						PARP8_uc011cpz.1_Intron|PARP8_uc003joo.2_Intron|PARP8_uc003jop.2_Intron	NM_024615	NP_078891			poly (ADP-ribose) polymerase family, member 8							intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)																---	---	---	---
ITGA1	3672	broad.mit.edu	37	5	52206388	52206389	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:52206388_52206389insT	uc003jou.2	+						ITGA1_uc003jov.2_Intron|ITGA1_uc003jow.2_Intron	NM_181501	NP_852478			integrin, alpha 1 precursor						axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|muscle contraction	integrin complex	collagen binding|receptor activity			ovary(2)|lung(1)	3		Lung NSC(810;5.05e-05)|Breast(144;0.0851)																---	---	---	---
GZMA	3001	broad.mit.edu	37	5	54398401	54398401	+	5'Flank	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:54398401delA	uc003jpm.2	+							NM_006144	NP_006135			granzyme A precursor						cleavage of lamin|cytolysis|immune response|negative regulation of DNA binding|negative regulation of endodeoxyribonuclease activity|negative regulation of oxidoreductase activity|positive regulation of apoptosis	extracellular region|immunological synapse|nucleus	protein homodimerization activity|serine-type endopeptidase activity			ovary(2)|pancreas(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.183)																---	---	---	---
CDC20B	166979	broad.mit.edu	37	5	54456702	54456702	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:54456702delA	uc003jpo.1	-						CDC20B_uc003jpn.1_Intron|CDC20B_uc010ivu.1_Intron|CDC20B_uc010ivv.1_Intron|CDC20B_uc003jpp.2_Intron|GPX8_uc003jpq.2_Intron|GPX8_uc003jpr.2_Intron|GPX8_uc003jps.2_Intron|GPX8_uc003jpt.2_Intron	NM_152623	NP_689836			CDC20 cell division cycle 20 homolog B isoform												0		Lung NSC(810;0.000744)|Breast(144;0.159)|Prostate(74;0.194)	LUSC - Lung squamous cell carcinoma(15;0.225)															---	---	---	---
SKIV2L2	23517	broad.mit.edu	37	5	54641102	54641102	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:54641102delT	uc003jpy.3	+						SKIV2L2_uc011cqi.1_Intron	NM_015360	NP_056175			superkiller viralicidic activity 2-like 2						maturation of 5.8S rRNA	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(1)|skin(1)	2		Lung NSC(810;0.000744)|Breast(144;0.181)|Prostate(74;0.194)																---	---	---	---
SLC38A9	153129	broad.mit.edu	37	5	54944946	54944946	+	Intron	DEL	A	-	-	rs35843566		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:54944946delA	uc003jqf.2	-						SLC38A9_uc003jqd.2_Intron|SLC38A9_uc010ivx.2_Intron|SLC38A9_uc003jqe.2_Intron|SLC38A9_uc010ivy.2_Intron	NM_173514	NP_775785			solute carrier family 38, member 9						amino acid transport|sodium ion transport	integral to membrane					0		Lung NSC(810;0.00122)|Prostate(74;0.0376)|Breast(144;0.181)																---	---	---	---
ACTBL2	345651	broad.mit.edu	37	5	56778450	56778450	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:56778450delG	uc003jrm.2	-	1	187	c.85delC	c.(85-87)CGGfs	p.R29fs		NM_001017992	NP_001017992	Q562R1	ACTBL_HUMAN	actin, beta-like 2	29						cytoplasm|cytoskeleton	ATP binding			ovary(3)	3		Lung NSC(810;0.000135)|Prostate(74;0.055)|Breast(144;0.0707)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;4.24e-37)														---	---	---	---
ERCC8	1161	broad.mit.edu	37	5	60195752	60195752	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:60195752delA	uc003jsm.3	-						ERCC8_uc003jsk.2_Intron|ERCC8_uc003jsl.3_Intron|ERCC8_uc011cqp.1_Intron	NM_000082	NP_000073			excision repair cross-complementing rodent						positive regulation of DNA repair|proteasomal ubiquitin-dependent protein catabolic process|protein autoubiquitination|protein polyubiquitination|response to oxidative stress|response to UV|response to UV|transcription-coupled nucleotide-excision repair	Cul4A-RING ubiquitin ligase complex|nuclear matrix|nucleoplasm|nucleotide-excision repair complex|soluble fraction	protein binding|protein complex binding				0		Lung NSC(810;1.51e-06)|Prostate(74;0.0322)|Ovarian(174;0.0481)|Breast(144;0.077)											Direct_reversal_of_damage|NER					---	---	---	---
ISCA1P1	389293	broad.mit.edu	37	5	62072505	62072505	+	3'UTR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:62072505delA	uc003jtf.2	-	2						NM_001080540	NP_001074009			iron-sulfur cluster assembly 1 homolog (S.												0																		---	---	---	---
SFRS12IP1	285672	broad.mit.edu	37	5	64023941	64023941	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:64023941delT	uc003jtk.2	-	4	423	c.271delA	c.(271-273)AGGfs	p.R91fs		NM_173829	NP_776190	Q8N9Q2	SR1IP_HUMAN	P18SRP protein	91	Lys-rich.				mRNA processing|RNA splicing		nucleic acid binding|zinc ion binding				0		Lung NSC(167;1.66e-05)|Prostate(74;0.0138)|Ovarian(174;0.0545)|Colorectal(97;0.234)		Lung(70;0.119)														---	---	---	---
PPWD1	23398	broad.mit.edu	37	5	64865337	64865338	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:64865337_64865338insT	uc003jtv.3	+						PPWD1_uc011cqv.1_Intron|PPWD1_uc011cqw.1_Intron	NM_015342	NP_056157			peptidylprolyl isomerase domain and WD repeat						protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity			ovary(1)	1		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		Lung(70;0.00451)														---	---	---	---
NLN	57486	broad.mit.edu	37	5	65029555	65029556	+	Intron	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:65029555_65029556delTT	uc003juf.2	+						NLN_uc003jue.2_Intron	NM_020726	NP_065777			neurolysin precursor						proteolysis	mitochondrial intermembrane space	metal ion binding|metalloendopeptidase activity			central_nervous_system(1)	1		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0743)|Lung(70;0.00616)														---	---	---	---
SLC30A5	64924	broad.mit.edu	37	5	68417499	68417499	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:68417499delT	uc003jvh.2	+						SLC30A5_uc003jvj.2_Intron|SLC30A5_uc003jvk.2_Intron|SLC30A5_uc003jvi.2_Intron	NM_022902	NP_075053			solute carrier family 30 (zinc transporter),						cellular zinc ion homeostasis|cobalt ion transport|regulation of proton transport|response to zinc ion	apical plasma membrane|Golgi apparatus|integral to plasma membrane|membrane fraction|secretory granule membrane	zinc ion binding|zinc ion transmembrane transporter activity			central_nervous_system(1)	1		Lung NSC(167;0.000986)|Prostate(74;0.00809)|Colorectal(97;0.0508)|Ovarian(174;0.16)		OV - Ovarian serous cystadenocarcinoma(47;1.24e-56)|Epithelial(20;1.12e-52)|all cancers(19;2.63e-48)|Lung(70;0.0177)														---	---	---	---
GTF2H2C	728340	broad.mit.edu	37	5	68875827	68875827	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:68875827delA	uc003jwx.3	+						GTF2H2C_uc003jww.1_3'UTR|GTF2H2C_uc003jwz.3_Intron|GTF2H2C_uc011cre.1_Intron|GTF2H2C_uc003jwy.3_Intron|GTF2H2C_uc003jxa.1_5'Flank	NM_001098728	NP_001092198			general transcription factor IIH, polypeptide						DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding				0																		---	---	---	---
SMN2	6607	broad.mit.edu	37	5	70247737	70247737	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:70247737delT	uc003kak.2	+						uc010iyh.1_Intron|uc003jzx.2_Intron|SMN1_uc011crr.1_Intron|SMN2_uc003kal.2_Intron|SMN2_uc003kam.2_Intron|SMN2_uc003kan.2_Intron|SMN2_uc003kap.1_Intron	NM_017411	NP_059107			survival of motor neuron 2, centromeric isoform						cell death|ncRNA metabolic process|spliceosomal snRNP assembly|spliceosome assembly	Cajal body|cytosol|spliceosomal complex	protein binding|protein binding|RNA binding				0		Lung NSC(167;4.15e-05)|Prostate(74;0.00996)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;3.04e-60)|Epithelial(20;7.09e-58)|all cancers(19;1.13e-53)|Lung(70;0.0174)														---	---	---	---
MRPS27	23107	broad.mit.edu	37	5	71533661	71533661	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:71533661delT	uc003kbz.3	-						MRPS27_uc003kca.3_Intron|MRPS27_uc011cse.1_Intron|MRPS27_uc010iza.2_Intron|MRPS27_uc010iyz.1_Intron	NM_015084	NP_055899			mitochondrial ribosomal protein S27							mitochondrion|ribosome					0		Lung NSC(167;0.00237)|Ovarian(174;0.0175)|Prostate(461;0.141)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.46e-53)														---	---	---	---
FAM169A	26049	broad.mit.edu	37	5	74135799	74135799	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:74135799delA	uc003kdm.2	-						FAM169A_uc010izm.2_Intron|FAM169A_uc003kdl.2_Intron	NM_015566	NP_056381			hypothetical protein LOC26049												0																		---	---	---	---
AP3B1	8546	broad.mit.edu	37	5	77458455	77458455	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:77458455delA	uc003kfj.2	-							NM_003664	NP_003655			adaptor-related protein complex 3, beta 1						endocytosis|melanosome organization	clathrin coated vesicle membrane|Golgi apparatus|membrane coat	protein phosphatase binding|protein transporter activity			central_nervous_system(1)	1		all_lung(232;0.000397)|Lung NSC(167;0.00106)|Ovarian(174;0.0105)|Prostate(461;0.215)		OV - Ovarian serous cystadenocarcinoma(54;8.23e-47)|Epithelial(54;2.74e-41)|all cancers(79;4.8e-36)										Hermansky-Pudlak_syndrome				---	---	---	---
FAM151B	167555	broad.mit.edu	37	5	79809324	79809324	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:79809324delT	uc003kgv.1	+						FAM151B_uc010jal.1_Intron	NM_205548	NP_991111			hypothetical protein LOC167555												0		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;8.21e-47)|Epithelial(54;8.3e-42)|all cancers(79;1.97e-36)														---	---	---	---
MSH3	4437	broad.mit.edu	37	5	80021182	80021182	+	Intron	DEL	T	-	-	rs79974413		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:80021182delT	uc003kgz.2	+							NM_002439	NP_002430			mutS homolog 3						maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			lung(2)|ovary(1)|breast(1)	4		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)									MMR					---	---	---	---
RASGRF2	5924	broad.mit.edu	37	5	80419682	80419682	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:80419682delT	uc003kha.1	+						RASGRF2_uc011ctn.1_Intron	NM_006909	NP_008840			Ras protein-specific guanine						apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			breast(5)|ovary(3)|large_intestine(2)|central_nervous_system(1)|skin(1)	12		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)														---	---	---	---
CCNH	902	broad.mit.edu	37	5	86705190	86705190	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:86705190delA	uc003kjb.2	-						CCNH_uc003kiy.1_5'Flank|CCNH_uc003kiz.1_Intron|CCNH_uc003kja.2_Intron	NM_001239	NP_001230			cyclin H						G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	cyclin-dependent protein kinase activating kinase holoenzyme complex|holo TFIIH complex	protein kinase binding			ovary(2)|kidney(1)	3		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;9.01e-39)|Epithelial(54;5.08e-33)|all cancers(79;4.28e-28)									Direct_reversal_of_damage|NER					---	---	---	---
TMEM161B	153396	broad.mit.edu	37	5	87491918	87491918	+	3'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:87491918delT	uc003kjc.2	-	12					TMEM161B_uc011cty.1_3'UTR|TMEM161B_uc010jax.2_RNA|TMEM161B_uc011ctx.1_3'UTR	NM_153354	NP_699185			transmembrane protein 161B							integral to membrane				skin(2)	2		all_cancers(142;0.000275)|Lung NSC(167;0.00901)|all_lung(232;0.0111)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;6.24e-36)|Epithelial(54;6.8e-31)|all cancers(79;1.07e-26)														---	---	---	---
TMEM161B	153396	broad.mit.edu	37	5	87492365	87492366	+	Intron	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:87492365_87492366delAA	uc003kjc.2	-						TMEM161B_uc011cty.1_Intron|TMEM161B_uc010jax.2_Intron|TMEM161B_uc011ctx.1_Intron	NM_153354	NP_699185			transmembrane protein 161B							integral to membrane				skin(2)	2		all_cancers(142;0.000275)|Lung NSC(167;0.00901)|all_lung(232;0.0111)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;6.24e-36)|Epithelial(54;6.8e-31)|all cancers(79;1.07e-26)														---	---	---	---
Unknown	0	broad.mit.edu	37	5	88952908	88952908	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:88952908delT								MEF2C (753039 upstream) : CETN3 (736623 downstream)																																			---	---	---	---
LYSMD3	116068	broad.mit.edu	37	5	89814745	89814748	+	Frame_Shift_Del	DEL	TCTC	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:89814745_89814748delTCTC	uc003kjr.2	-	3	957_960	c.809_812delGAGA	c.(808-813)AGAGAAfs	p.R270fs	LYSMD3_uc010jaz.1_Frame_Shift_Del_p.E112fs|LYSMD3_uc003kjs.1_3'UTR	NM_198273	NP_938014	Q7Z3D4	LYSM3_HUMAN	LysM, putative peptidoglycan-binding, domain	270_271	Cytoplasmic (Potential).				cell wall macromolecule catabolic process	integral to membrane					0		all_cancers(142;5.03e-09)|all_epithelial(76;1.23e-11)|Lung NSC(167;2.46e-05)|all_lung(232;3.25e-05)|Ovarian(174;0.00832)|Colorectal(57;0.122)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(54;1.94e-31)|Epithelial(54;5.22e-26)|all cancers(79;2.42e-22)														---	---	---	---
GPR98	84059	broad.mit.edu	37	5	89939932	89939932	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:89939932delT	uc003kju.2	+						GPR98_uc003kjt.2_Intron	NM_032119	NP_115495			G protein-coupled receptor 98 precursor						cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)														---	---	---	---
TTC37	9652	broad.mit.edu	37	5	94826831	94826831	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:94826831delA	uc003klb.2	-							NM_014639	NP_055454			tetratricopeptide repeat domain 37								binding			ovary(3)|pancreas(1)	4																		---	---	---	---
PAM	5066	broad.mit.edu	37	5	102295563	102295563	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:102295563delT	uc003knw.2	+						PAM_uc003kns.2_Intron|PAM_uc003knt.2_Intron|PAM_uc003knu.2_Intron|PAM_uc003knv.2_Intron|PAM_uc011cuz.1_Intron|PAM_uc003knx.1_5'Flank	NM_000919	NP_000910			peptidylglycine alpha-amidating monooxygenase						peptide metabolic process|protein modification process	extracellular region|integral to membrane|stored secretory granule	L-ascorbic acid binding|peptidylamidoglycolate lyase activity|peptidylglycine monooxygenase activity|protein binding				0		all_cancers(142;3.12e-07)|all_epithelial(76;3.48e-10)|Prostate(80;0.00914)|Lung NSC(167;0.0213)|Ovarian(225;0.024)|Colorectal(57;0.0251)|all_lung(232;0.0284)		Epithelial(69;1.1e-13)|COAD - Colon adenocarcinoma(37;0.0127)	Vitamin C(DB00126)													---	---	---	---
PPIP5K2	23262	broad.mit.edu	37	5	102491492	102491492	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:102491492delT	uc003kod.3	+						PPIP5K2_uc011cva.1_Intron|PPIP5K2_uc003koe.2_Intron|PPIP5K2_uc010jbo.1_Intron	NM_015216	NP_056031			Histidine acid phosphatase domain containing 1						inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			ovary(1)|skin(1)	2																		---	---	---	---
FER	2241	broad.mit.edu	37	5	108294833	108294834	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:108294833_108294834insT	uc003kop.1	+						FER_uc011cvf.1_Intron|FER_uc011cvg.1_Intron	NM_005246	NP_005237			fer (fps/fes related) tyrosine kinase						intracellular signal transduction|peptidyl-tyrosine phosphorylation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|kidney(1)	5		all_cancers(142;2.86e-06)|all_epithelial(76;9.81e-08)|Prostate(80;0.00972)|Lung NSC(167;0.039)|Ovarian(225;0.0448)|all_lung(232;0.0496)|Colorectal(57;0.0986)|Breast(839;0.152)		OV - Ovarian serous cystadenocarcinoma(64;6.77e-10)|Epithelial(69;4.13e-08)|COAD - Colon adenocarcinoma(37;0.0174)														---	---	---	---
TMEM232	642987	broad.mit.edu	37	5	109877943	109877943	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:109877943delT	uc011cvh.1	-						TMEM232_uc003kow.1_Intron|TMEM232_uc003kox.2_Intron|TMEM232_uc010jbs.2_Intron|TMEM232_uc003koy.3_Intron					SubName: Full=cDNA FLJ54480;							integral to membrane					0																		---	---	---	---
CAMK4	814	broad.mit.edu	37	5	110712764	110712764	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:110712764delA	uc011cvj.1	+						CAMK4_uc003kpf.2_Intron|CAMK4_uc010jbv.2_Intron	NM_001744	NP_001735			calcium/calmodulin-dependent protein kinase IV						activation of phospholipase C activity|nerve growth factor receptor signaling pathway|synaptic transmission	cytosol|nucleoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(3)|lung(2)	5		all_cancers(142;1.49e-05)|all_epithelial(76;1.82e-07)|Prostate(80;0.00964)|all_lung(232;0.0181)|Lung NSC(167;0.0298)|Ovarian(225;0.0446)|Colorectal(57;0.0478)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;3.79e-08)|Epithelial(69;5.29e-08)|all cancers(49;1.1e-05)|COAD - Colon adenocarcinoma(37;0.109)														---	---	---	---
EPB41L4A	64097	broad.mit.edu	37	5	111545530	111545530	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:111545530delA	uc003kpv.1	-						EPB41L4A_uc003kpp.1_Intron	NM_022140	NP_071423			erythrocyte protein band 4.1-like 4							cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			ovary(1)	1		all_cancers(142;4.93e-06)|all_epithelial(76;2.28e-08)|Prostate(80;0.000244)|Colorectal(10;0.000788)|Ovarian(225;0.0448)|Lung NSC(167;0.126)|all_lung(232;0.135)		OV - Ovarian serous cystadenocarcinoma(64;6.24e-09)|Epithelial(69;1.43e-07)|all cancers(49;2.78e-05)|COAD - Colon adenocarcinoma(37;0.0467)|Colorectal(14;0.0791)														---	---	---	---
APC	324	broad.mit.edu	37	5	112176242	112176243	+	Frame_Shift_Del	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:112176242_112176243delTT	uc010jby.2	+	16	5331_5332	c.4951_4952delTT	c.(4951-4953)TTTfs	p.F1651fs	APC_uc011cvt.1_Frame_Shift_Del_p.F1633fs|APC_uc003kpz.3_Frame_Shift_Del_p.F1651fs|APC_uc003kpy.3_Frame_Shift_Del_p.F1651fs|APC_uc010jbz.2_Frame_Shift_Del_p.F1368fs|APC_uc010jca.2_Frame_Shift_Del_p.F951fs	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	1651	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.K1192fs*3(1)|p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)			12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			---	---	---	---
DCP2	167227	broad.mit.edu	37	5	112328171	112328171	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:112328171delT	uc003kqh.2	+						DCP2_uc011cwa.1_Intron|DCP2_uc010jcc.2_Intron	NM_152624	NP_689837			DCP2 decapping enzyme						exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasmic mRNA processing body|cytosol|nucleus|RNA-induced silencing complex	exoribonuclease activity, producing 5'-phosphomonoesters|manganese ion binding|protein binding|protein binding|RNA binding				0		all_cancers(142;4.41e-05)|all_epithelial(76;3.65e-07)|Colorectal(10;0.00115)|Prostate(80;0.00133)|Ovarian(225;0.0443)		OV - Ovarian serous cystadenocarcinoma(64;6.98e-08)|Epithelial(69;7.87e-08)|all cancers(49;1.06e-05)|COAD - Colon adenocarcinoma(37;0.0123)|Colorectal(14;0.0171)														---	---	---	---
Unknown	0	broad.mit.edu	37	5	115106723	115106723	+	IGR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:115106723delA								TMED7-TICAM2 (144853 upstream) : CDO1 (33709 downstream)																																			---	---	---	---
ATG12	9140	broad.mit.edu	37	5	115168246	115168246	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:115168246delA	uc003krh.2	-						ATG12_uc003kri.2_Intron|ATG12_uc003krj.2_Intron	NM_004707	NP_004698			APG12 autophagy 12-like						autophagic vacuole assembly|negative regulation of type I interferon production	pre-autophagosomal structure membrane	protein binding				0		all_cancers(142;0.00377)|all_epithelial(76;0.000129)|Prostate(80;0.0132)|Ovarian(225;0.0776)|Lung NSC(810;0.245)		OV - Ovarian serous cystadenocarcinoma(64;7.59e-08)|Epithelial(69;7.05e-07)|all cancers(49;3.11e-05)														---	---	---	---
HSD17B4	3295	broad.mit.edu	37	5	118866876	118866876	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:118866876delT	uc003ksj.2	+						HSD17B4_uc011cwg.1_Intron|HSD17B4_uc011cwh.1_Intron|HSD17B4_uc011cwi.1_Intron|HSD17B4_uc003ksk.3_Intron|HSD17B4_uc011cwj.1_Intron|HSD17B4_uc010jcn.1_Intron|HSD17B4_uc010jco.1_Intron	NM_000414	NP_000405			hydroxysteroid (17-beta) dehydrogenase 4						bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3-hydroxyacyl-CoA dehydrogenase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity|estradiol 17-beta-dehydrogenase activity|isomerase activity|long-chain-enoyl-CoA hydratase activity|protein binding|sterol binding|sterol transporter activity			ovary(1)|pancreas(1)	2		all_cancers(142;0.0206)|Prostate(80;0.0322)		OV - Ovarian serous cystadenocarcinoma(64;0.000247)|Epithelial(69;0.000849)|all cancers(49;0.0122)	NADH(DB00157)													---	---	---	---
Unknown	0	broad.mit.edu	37	5	120952552	120952552	+	IGR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:120952552delA								PRR16 (929590 upstream) : FTMT (235098 downstream)																																			---	---	---	---
SNX24	28966	broad.mit.edu	37	5	122343344	122343344	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:122343344delT	uc011cwo.1	+						SNX24_uc010jcy.2_Intron	NM_014035	NP_054754			SBBI31 protein						cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding				0		Prostate(80;0.0387)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	OV - Ovarian serous cystadenocarcinoma(64;0.000654)|Epithelial(69;0.0016)|all cancers(49;0.0139)														---	---	---	---
Unknown	0	broad.mit.edu	37	5	123556070	123556073	+	IGR	DEL	AAAA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:123556070_123556073delAAAA								CSNK1G3 (603608 upstream) : ZNF608 (416537 downstream)																																			---	---	---	---
ALDH7A1	501	broad.mit.edu	37	5	125918482	125918482	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:125918482delT	uc003ktx.2	-						ALDH7A1_uc003kty.2_Intron|ALDH7A1_uc011cxa.1_Intron|ALDH7A1_uc003ktz.2_Intron	NM_001182	NP_001173			aldehyde dehydrogenase 7 family, member A1						cellular aldehyde metabolic process|lysine catabolic process|sensory perception of sound	cytosol|mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity|betaine-aldehyde dehydrogenase activity|L-aminoadipate-semialdehyde dehydrogenase activity			kidney(2)|ovary(1)	3		all_cancers(142;0.24)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.0584)|Kidney(363;0.0934)	Epithelial(69;0.0417)|OV - Ovarian serous cystadenocarcinoma(64;0.068)|all cancers(49;0.109)	NADH(DB00157)|Pyridoxine(DB00165)													---	---	---	---
FBN2	2201	broad.mit.edu	37	5	127782405	127782405	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:127782405delT	uc003kuu.2	-						FBN2_uc003kuv.2_Intron|FBN2_uc003kuw.3_Intron|FBN2_uc003kux.1_Intron	NM_001999	NP_001990			fibrillin 2 precursor						bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)														---	---	---	---
Unknown	0	broad.mit.edu	37	5	130344290	130344290	+	IGR	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:130344290delG								CHSY3 (821964 upstream) : HINT1 (150585 downstream)																																			---	---	---	---
KIF3A	11127	broad.mit.edu	37	5	132069870	132069870	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:132069870delT	uc003kxo.2	-						KIF3A_uc003kxn.2_Intron|KIF3A_uc011cxf.1_Intron|KIF3A_uc003kxp.2_Intron	NM_007054	NP_008985			kinesin family member 3A						blood coagulation|organelle organization|plus-end-directed vesicle transport along microtubule	centrosome|cytosol|kinesin II complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|protein binding			pancreas(1)	1		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)															---	---	---	---
BRD8	10902	broad.mit.edu	37	5	137496760	137496760	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:137496760delA	uc003lcf.1	-						BRD8_uc003lcc.1_Intron|BRD8_uc011cyl.1_Intron|BRD8_uc003lcg.2_Intron|BRD8_uc003lci.2_Intron|BRD8_uc003lch.2_Intron|BRD8_uc011cym.1_Intron|BRD8_uc010jer.1_Intron|BRD8_uc011cyn.1_Intron	NM_139199	NP_631938			bromodomain containing 8 isoform 2						cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)															---	---	---	---
CDC23	8697	broad.mit.edu	37	5	137527901	137527901	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:137527901delA	uc003lcl.2	-							NM_004661	NP_004652			cell division cycle protein 23						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G1 phase of mitotic cell cycle|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase plate congression|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of exit from mitosis	anaphase-promoting complex|cytosol|nucleoplasm	binding|ubiquitin-protein ligase activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)															---	---	---	---
CDC23	8697	broad.mit.edu	37	5	137528539	137528539	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:137528539delA	uc003lcl.2	-							NM_004661	NP_004652			cell division cycle protein 23						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G1 phase of mitotic cell cycle|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase plate congression|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of exit from mitosis	anaphase-promoting complex|cytosol|nucleoplasm	binding|ubiquitin-protein ligase activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)															---	---	---	---
ETF1	2107	broad.mit.edu	37	5	137853409	137853409	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:137853409delT	uc003ldc.3	-						ETF1_uc011cyv.1_Intron|ETF1_uc010jex.2_Intron|ETF1_uc003ldd.3_Intron|ETF1_uc010jey.1_5'Flank	NM_004730	NP_004721			eukaryotic translation termination factor 1						nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|protein methylation|regulation of translational termination	cytoplasm	protein binding|ribosome binding|translation release factor activity, codon specific			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)															---	---	---	---
SIL1	64374	broad.mit.edu	37	5	138378134	138378134	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:138378134delT	uc003ldm.2	-						SIL1_uc003ldn.2_Intron|SIL1_uc003ldo.2_Intron|SIL1_uc003ldp.2_Intron|SIL1_uc003ldq.1_Intron	NM_022464	NP_071909			SIL1 protein precursor						intracellular protein transport|protein folding|transmembrane transport	endoplasmic reticulum lumen	unfolded protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)											Marinesco-Sj_gren_syndrome				---	---	---	---
PCDHB14	56122	broad.mit.edu	37	5	140604247	140604247	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140604247delT	uc003ljb.2	+	1	1170	c.1170delT	c.(1168-1170)CCTfs	p.P390fs	PCDHB14_uc011dal.1_Frame_Shift_Del_p.P237fs	NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	protocadherin beta 14 precursor	390	Cadherin 4.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)															---	---	---	---
FCHSD1	89848	broad.mit.edu	37	5	141030071	141030071	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:141030071delG	uc003llk.2	-						FCHSD1_uc010jgg.2_5'Flank|FCHSD1_uc003llj.2_Intron	NM_033449	NP_258260			FCH and double SH3 domains 1										FCHSD1/BRAF(2)	skin(2)|ovary(1)|central_nervous_system(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDH1	5097	broad.mit.edu	37	5	141242815	141242815	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:141242815delG	uc003llq.2	-	3	3198	c.3081delC	c.(3079-3081)CCCfs	p.P1027fs	PCDH1_uc003llp.2_Frame_Shift_Del_p.P1027fs|PCDH1_uc011dbf.1_Frame_Shift_Del_p.P1005fs	NM_002587	NP_002578	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 1 precursor	1027	Cytoplasmic (Potential).				cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)														---	---	---	---
NDFIP1	80762	broad.mit.edu	37	5	141511617	141511618	+	Intron	INS	-	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:141511617_141511618insC	uc003lmi.3	+						NDFIP1_uc003lmj.1_Intron	NM_030571	NP_085048			Nedd4 family interacting protein 1						cellular iron ion homeostasis|negative regulation of gene expression|negative regulation of protein transport|negative regulation of transporter activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of protein ubiquitination	endosome membrane|extracellular region|Golgi membrane|integral to membrane|perinuclear region of cytoplasm	signal transducer activity				0		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
RBM27	54439	broad.mit.edu	37	5	145649280	145649280	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:145649280delA	uc003lnz.3	+							NM_018989	NP_061862			RNA binding motif protein 27						mRNA processing	cytoplasm|nuclear speck	nucleotide binding|RNA binding|zinc ion binding			central_nervous_system(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)															---	---	---	---
TCERG1	10915	broad.mit.edu	37	5	145843206	145843206	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:145843206delG	uc003lob.2	+	5	1025	c.985delG	c.(985-987)GTGfs	p.V329fs	TCERG1_uc003loc.2_Frame_Shift_Del_p.V329fs|TCERG1_uc011dbt.1_Frame_Shift_Del_p.V329fs	NM_006706	NP_006697	O14776	TCRG1_HUMAN	transcription elongation regulator 1 isoform 1	329	Pro-rich.|Thr-rich.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			ovary(1)|skin(1)	2		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)															---	---	---	---
JAKMIP2	9832	broad.mit.edu	37	5	147117721	147117721	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:147117721delT	uc003loq.1	-						JAKMIP2_uc011dbx.1_Intron|JAKMIP2_uc003lor.1_Intron	NM_014790	NP_055605			janus kinase and microtubule interacting protein							Golgi apparatus				large_intestine(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
SPINK5	11005	broad.mit.edu	37	5	147505129	147505129	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:147505129delT	uc003lox.2	+						SPINK5_uc003loy.2_Frame_Shift_Del_p.F928fs	NM_006846	NP_006837			serine peptidase inhibitor, Kazal type 5 isoform						anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)|breast(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
GRPEL2	134266	broad.mit.edu	37	5	148730613	148730613	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:148730613delT	uc003lqj.2	+	4	572	c.446delT	c.(445-447)CTTfs	p.L149fs	GRPEL2_uc011dca.1_Frame_Shift_Del_p.F122fs	NM_152407	NP_689620	Q8TAA5	GRPE2_HUMAN	GrpE-like 2, mitochondrial precursor	149					protein folding	mitochondrial matrix	adenyl-nucleotide exchange factor activity|chaperone binding|protein homodimerization activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
NDST1	3340	broad.mit.edu	37	5	149919109	149919109	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:149919109delT	uc003lsk.3	+						NDST1_uc011dcj.1_Intron|NDST1_uc003lsl.2_3'UTR	NM_001543	NP_001534			N-deacetylase/N-sulfotransferase (heparan						heparan sulfate proteoglycan biosynthetic process|inflammatory response	Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			breast(1)|skin(1)	2		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)															---	---	---	---
DCTN4	51164	broad.mit.edu	37	5	150102363	150102363	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:150102363delT	uc003lsv.2	-						DCTN4_uc003lsu.2_Intron|DCTN4_uc010jhi.2_Intron	NM_016221	NP_057305			dynactin 4 (p62) isoform b							centrosome|nucleus	protein N-terminus binding			central_nervous_system(1)	1		Medulloblastoma(196;0.167)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)															---	---	---	---
DCTN4	51164	broad.mit.edu	37	5	150111159	150111159	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:150111159delA	uc003lsv.2	-						DCTN4_uc003lsu.2_Intron|DCTN4_uc010jhi.2_Intron|DCTN4_uc010jhj.2_Intron|DCTN4_uc011dck.1_Intron	NM_016221	NP_057305			dynactin 4 (p62) isoform b							centrosome|nucleus	protein N-terminus binding			central_nervous_system(1)	1		Medulloblastoma(196;0.167)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)															---	---	---	---
GALNT10	55568	broad.mit.edu	37	5	153718077	153718077	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:153718077delT	uc003lvh.2	+						GALNT10_uc003lvg.1_Intron|GALNT10_uc010jic.2_Intron|GALNT10_uc010jid.2_Intron	NM_198321	NP_938080			GalNAc transferase 10 isoform a							Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)|all_hematologic(541;0.21)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)															---	---	---	---
GEMIN5	25929	broad.mit.edu	37	5	154305380	154305380	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:154305380delA	uc003lvx.3	-						GEMIN5_uc011ddk.1_Intron	NM_015465	NP_056280			gemin 5						ncRNA metabolic process|protein complex assembly|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding|snRNA binding			skin(2)|ovary(1)	3	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)															---	---	---	---
SGCD	6444	broad.mit.edu	37	5	156021886	156021887	+	Intron	DEL	TC	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:156021886_156021887delTC	uc003lwd.3	+						SGCD_uc003lwa.1_Intron|SGCD_uc003lwb.2_Intron|SGCD_uc003lwc.3_Intron	NM_001128209	NP_001121681			delta-sarcoglycan isoform 3						cytoskeleton organization|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma					0	Renal(175;0.00488)	Medulloblastoma(196;0.0378)|all_neural(177;0.106)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)															---	---	---	---
TIMD4	91937	broad.mit.edu	37	5	156381896	156381896	+	Intron	DEL	T	-	-	rs71922795		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:156381896delT	uc003lwh.2	-						TIMD4_uc010jii.2_Intron	NM_138379	NP_612388			T-cell immunoglobulin and mucin domain							integral to membrane				ovary(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)															---	---	---	---
ITK	3702	broad.mit.edu	37	5	156649831	156649831	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:156649831delT	uc003lwo.1	+							NM_005546	NP_005537			IL2-inducible T-cell kinase						cellular defense response|intracellular signal transduction|T cell receptor signaling pathway	cytosol|plasma membrane	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(12)|ovary(8)|skin(4)|stomach(1)|central_nervous_system(1)	26	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.1)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)					T	SYK	peripheral T-cell lymphoma								---	---	---	---
EBF1	1879	broad.mit.edu	37	5	158526597	158526597	+	5'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:158526597delT	uc010jip.2	-	1					EBF1_uc011ddw.1_5'Flank|EBF1_uc011ddx.1_5'UTR|EBF1_uc003lxl.3_5'UTR|uc003lxm.1_5'Flank	NM_024007	NP_076870			early B-cell factor						multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	soft_tissue(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)					T	HMGA2	lipoma								---	---	---	---
RNF145	153830	broad.mit.edu	37	5	158634513	158634513	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:158634513delA	uc003lxp.2	-						RNF145_uc011ddy.1_5'UTR|RNF145_uc003lxo.1_Intron|RNF145_uc011ddz.1_Intron|RNF145_uc010jiq.1_Intron|RNF145_uc011dea.1_Intron	NM_144726	NP_653327			ring finger protein 145							integral to membrane	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0523)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)															---	---	---	---
GABRA6	2559	broad.mit.edu	37	5	161116981	161116981	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:161116981delT	uc003lyu.2	+						GABRA6_uc003lyv.2_5'UTR	NM_000811	NP_000802			gamma-aminobutyric acid A receptor, alpha 6						gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)										TCGA Ovarian(5;0.080)			---	---	---	---
RARS	5917	broad.mit.edu	37	5	167944139	167944139	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:167944139delT	uc003lzx.2	+						RARS_uc011deo.1_Intron	NM_002887	NP_002878			arginyl-tRNA synthetase						arginyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	arginine-tRNA ligase activity|ATP binding|protein binding			ovary(2)|skin(1)	3	Renal(175;0.000159)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0208)|all_neural(177;0.0227)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0693)|Epithelial(171;0.131)|OV - Ovarian serous cystadenocarcinoma(192;0.156)														---	---	---	---
CCDC99	54908	broad.mit.edu	37	5	169015404	169015404	+	5'UTR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:169015404delA	uc003mae.3	+	2					CCDC99_uc010jjj.2_5'UTR|CCDC99_uc011deq.1_5'UTR|CCDC99_uc010jjk.2_5'UTR	NM_017785	NP_060255			coiled-coil domain containing 99						cell division|establishment of mitotic spindle orientation|mitotic metaphase plate congression|mitotic prometaphase|protein localization to kinetochore	condensed chromosome outer kinetochore|cytosol|microtubule organizing center|nucleus|spindle pole	kinetochore binding|protein binding			ovary(1)|liver(1)	2	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)															---	---	---	---
KCNIP1	30820	broad.mit.edu	37	5	170139727	170139728	+	Intron	DEL	GA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:170139727_170139728delGA	uc003mas.2	+						KCNIP1_uc003map.2_Intron|KCNIP1_uc003mat.2_Intron|KCNIP1_uc010jjp.2_Intron|KCNIP1_uc010jjq.2_Intron	NM_001034837	NP_001030009			Kv channel interacting protein 1 isoform 1						detection of calcium ion|signal transduction|synaptic transmission	plasma membrane	potassium channel activity|voltage-gated ion channel activity			skin(2)	2	Renal(175;0.000159)|Lung NSC(126;0.0191)|all_lung(126;0.0297)	Medulloblastoma(196;0.0109)|all_neural(177;0.0177)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)															---	---	---	---
GABRP	2568	broad.mit.edu	37	5	170221219	170221219	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:170221219delT	uc003mau.2	+						GABRP_uc011dev.1_Intron	NM_014211	NP_055026			gamma-aminobutyric acid (GABA) A receptor, pi							cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)															---	---	---	---
NPM1	4869	broad.mit.edu	37	5	170819655	170819655	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:170819655delT	uc011dex.1	+						NPM1_uc003mbh.2_Intron|NPM1_uc003mbi.2_Intron|NPM1_uc003mbj.2_Intron	NM_002520	NP_002511			nucleophosmin 1 isoform 1						anti-apoptosis|cell aging|CenH3-containing nucleosome assembly at centromere|centrosome cycle|DNA repair|interspecies interaction between organisms|intracellular protein transport|negative regulation of cell proliferation|negative regulation of centrosome duplication|nucleocytoplasmic transport|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|regulation of endodeoxyribonuclease activity|regulation of endoribonuclease activity|ribosome assembly|signal transduction	nucleolus|nucleoplasm|ribonucleoprotein complex|spindle pole centrosome	histone binding|NF-kappaB binding|protein binding|protein heterodimerization activity|protein homodimerization activity|ribosomal large subunit binding|ribosomal small subunit binding|RNA binding|Tat protein binding|transcription coactivator activity|unfolded protein binding		NPM1/ALK(632)	haematopoietic_and_lymphoid_tissue(3109)|skin(1)	3110	Renal(175;0.000159)|Lung NSC(126;0.00576)|all_lung(126;0.00963)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)					T|F 	ALK|RARA|MLF1	NHL|APL|AML								---	---	---	---
Unknown	0	broad.mit.edu	37	5	174350981	174350981	+	IGR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:174350981delA								MSX2 (193080 upstream) : DRD1 (516695 downstream)																																			---	---	---	---
C5orf25	375484	broad.mit.edu	37	5	175751795	175751796	+	Intron	INS	-	A	A	rs142932031	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:175751795_175751796insA	uc003mds.3	+						C5orf25_uc003mdt.3_Intron|C5orf25_uc003mdr.3_Intron|C5orf25_uc003mdv.2_Intron					RecName: Full=Uncharacterized protein C5orf25;												0	all_cancers(89;0.00381)|Renal(175;0.000269)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.119)														---	---	---	---
TSPAN17	26262	broad.mit.edu	37	5	176082910	176082912	+	Intron	DEL	AAC	-	-	rs6897431	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:176082910_176082912delAAC	uc003met.2	+						TSPAN17_uc003mes.3_Intron|TSPAN17_uc003meu.2_Intron|TSPAN17_uc003mev.2_Intron|TSPAN17_uc003mew.2_Intron	NM_012171	NP_036303			transmembrane 4 superfamily member 17 isoform a							integral to membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity				0	all_cancers(89;0.00141)|Renal(175;0.000269)|Lung NSC(126;0.00814)|all_lung(126;0.0133)	Medulloblastoma(196;0.00498)|all_neural(177;0.0212)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)															---	---	---	---
UIMC1	51720	broad.mit.edu	37	5	176395374	176395375	+	Intron	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:176395374_176395375delAA	uc011dfp.1	-						UIMC1_uc003mfc.1_Intron|UIMC1_uc003mfd.1_Intron|UIMC1_uc003mfg.1_Intron|UIMC1_uc003mff.1_Intron	NM_016290	NP_057374			ubiquitin interaction motif containing 1						double-strand break repair|G2/M transition DNA damage checkpoint|histone H2A K63-linked deubiquitination|negative regulation of transcription, DNA-dependent|positive regulation of DNA repair|response to ionizing radiation|transcription, DNA-dependent	BRCA1-A complex	histone binding|K63-linked polyubiquitin binding			ovary(3)|skin(1)	4	all_cancers(89;7.96e-05)|Renal(175;0.000269)|Lung NSC(126;0.00476)|all_lung(126;0.00806)	Medulloblastoma(196;0.0145)|all_neural(177;0.0325)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)															---	---	---	---
LMAN2	10960	broad.mit.edu	37	5	176773463	176773463	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:176773463delT	uc003mge.2	-						LMAN2_uc003mgd.2_Intron	NM_006816	NP_006807			lectin, mannose-binding 2 precursor						protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	metal ion binding|sugar binding				0	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)															---	---	---	---
CANX	821	broad.mit.edu	37	5	179135170	179135170	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:179135170delT	uc003mkk.2	+						CANX_uc011dgp.1_Intron|CANX_uc010jlb.1_Intron|CANX_uc003mkl.2_Intron|CANX_uc011dgq.1_Intron	NM_001746	NP_001737			calnexin precursor						post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein secretion	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane|melanosome	calcium ion binding|sugar binding|unfolded protein binding				0	all_cancers(89;0.000129)|all_epithelial(37;5.59e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0413)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
SQSTM1	8878	broad.mit.edu	37	5	179250925	179250925	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:179250925delC	uc003mkw.3	+	3	464	c.369delC	c.(367-369)CACfs	p.H123fs	SQSTM1_uc011dgr.1_Frame_Shift_Del_p.H39fs|SQSTM1_uc011dgs.1_Frame_Shift_Del_p.H39fs|SQSTM1_uc003mkv.3_Frame_Shift_Del_p.H123fs|SQSTM1_uc003mkx.2_Frame_Shift_Del_p.H39fs	NM_003900	NP_003891	Q13501	SQSTM_HUMAN	sequestosome 1 isoform 1	123	ZZ-type.|Interaction with GABRR3 (By similarity).				anti-apoptosis|apoptosis|cell differentiation|endosome transport|induction of apoptosis by extracellular signals|intracellular signal transduction|macroautophagy|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein localization|regulation of I-kappaB kinase/NF-kappaB cascade|ubiquitin-dependent protein catabolic process	cytosol|late endosome|nucleoplasm	protein kinase C binding|receptor tyrosine kinase binding|SH2 domain binding|ubiquitin binding|zinc ion binding		SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(2)|ovary(1)	3	all_cancers(89;0.000205)|all_epithelial(37;7.15e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0395)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)											Paget_Disease_of_Bone				---	---	---	---
WRNIP1	56897	broad.mit.edu	37	6	2785016	2785016	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:2785016delA	uc003mtz.2	+						WRNIP1_uc003mua.2_Intron	NM_020135	NP_064520			Werner helicase interacting protein isoform 1						DNA replication|DNA synthesis involved in DNA repair|regulation of DNA-dependent DNA replication initiation	mitochondrion|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|DNA binding|metal ion binding|protein binding			ovary(1)|pancreas(1)	2	Ovarian(93;0.0412)	all_hematologic(90;0.0895)																---	---	---	---
SERPINB9	5272	broad.mit.edu	37	6	2893821	2893821	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:2893821delT	uc003mug.2	-						uc003mue.2_Intron|SERPINB9_uc003muf.2_5'Flank	NM_004155	NP_004146			serpin peptidase inhibitor, clade B, member 9						anti-apoptosis|cellular response to estrogen stimulus|immune response|mast cell mediated immunity|regulation of proteolysis	cytosol|extracellular space|nucleus	caspase inhibitor activity|protease binding|serine-type endopeptidase inhibitor activity				0	Ovarian(93;0.0412)	all_hematologic(90;0.108)																---	---	---	---
PRPF4B	8899	broad.mit.edu	37	6	4042845	4042846	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:4042845_4042846insT	uc003mvv.2	+						PRPF4B_uc003mvw.2_Intron|PRPF4B_uc011dhv.1_Intron	NM_003913	NP_003904			serine/threonine-protein kinase PRP4K							catalytic step 2 spliceosome	ATP binding|protein binding|protein serine/threonine kinase activity			breast(5)	5	Ovarian(93;0.0925)	all_hematologic(90;0.0895)																---	---	---	---
HIVEP1	3096	broad.mit.edu	37	6	12164716	12164716	+	3'UTR	DEL	T	-	-	rs76772048		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:12164716delT	uc003nac.2	+	9					HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105			human immunodeficiency virus type I enhancer						transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)																---	---	---	---
SIRT5	23408	broad.mit.edu	37	6	13584591	13584591	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:13584591delT	uc003nay.2	+						SIRT5_uc003naw.2_Intron|SIRT5_uc003nax.2_Intron|SIRT5_uc011dit.1_Intron	NM_012241	NP_036373			sirtuin 5 isoform 1						chromatin silencing|protein ADP-ribosylation|protein deacetylation	mitochondrial intermembrane space|mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|zinc ion binding			skin(2)|upper_aerodigestive_tract(1)	3	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.176)		Suramin(DB04786)													---	---	---	---
KDM1B	221656	broad.mit.edu	37	6	18222307	18222307	+	3'UTR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:18222307delA	uc003nco.1	+	15					KDM1B_uc003ncn.1_3'UTR|KDM1B_uc003ncp.1_3'UTR|KDM1B_uc003ncq.1_Frame_Shift_Del_p.K203fs	NM_153042	NP_694587			amine oxidase (flavin containing) domain 1						multicellular organismal development|regulation of DNA methylation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-monomethyl-K4 specific)|oxidoreductase activity|zinc ion binding			skin(1)	1																		---	---	---	---
DEK	7913	broad.mit.edu	37	6	18263751	18263751	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:18263751delA	uc003ncr.1	-						DEK_uc011djf.1_Intron|DEK_uc011djg.1_Intron	NM_003472	NP_003463			DEK oncogene isoform 1						chromatin modification|regulation of transcription from RNA polymerase II promoter|signal transduction|transcription from RNA polymerase II promoter|viral genome replication	nucleus	DNA binding|histone binding			kidney(1)	1	Ovarian(93;0.00769)|Breast(50;0.0495)	all_hematologic(90;0.053)	OV - Ovarian serous cystadenocarcinoma(7;0.00291)|all cancers(50;0.031)|Epithelial(50;0.0332)					T	NUP214	AML								---	---	---	---
E2F3	1871	broad.mit.edu	37	6	20483287	20483288	+	Intron	DEL	TG	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:20483287_20483288delTG	uc003nda.2	+							NM_001949	NP_001940			E2F transcription factor 3						G1 phase of mitotic cell cycle|G2 phase of mitotic cell cycle|transcription initiation from RNA polymerase II promoter	transcription factor complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(1)	1	all_cancers(95;0.154)|all_epithelial(95;0.0585)|Breast(50;0.146)|Ovarian(93;0.148)		OV - Ovarian serous cystadenocarcinoma(7;0.0068)|all cancers(50;0.0148)|Epithelial(50;0.0562)															---	---	---	---
MRS2	57380	broad.mit.edu	37	6	24418490	24418491	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:24418490_24418491insT	uc003neb.2	+						MRS2_uc003nea.2_Intron|MRS2_uc011djl.1_Intron|MRS2_uc011djm.1_Intron|MRS2_uc011djn.1_Intron|MRS2_uc003nec.2_Intron	NM_020662	NP_065713			MRS2-like, magnesium homeostasis factor						ion transport	integral to membrane|mitochondrial inner membrane					0																		---	---	---	---
BTN1A1	696	broad.mit.edu	37	6	26509183	26509183	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:26509183delC	uc003nif.3	+	7	1382	c.1362delC	c.(1360-1362)GGCfs	p.G454fs		NM_001732	NP_001723	Q13410	BT1A1_HUMAN	butyrophilin, subfamily 1, member A1 precursor	454	B30.2/SPRY.|Cytoplasmic (Potential).					extracellular region|integral to plasma membrane	receptor activity			ovary(1)|skin(1)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	6	27178954	27178954	+	IGR	DEL	A	-	-	rs12206886		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:27178954delA								HIST1H2AH (63609 upstream) : PRSS16 (36554 downstream)																																			---	---	---	---
ZNF184	7738	broad.mit.edu	37	6	27424714	27424714	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:27424714delA	uc003njj.2	-						ZNF184_uc010jqv.2_Intron|ZNF184_uc003nji.2_Intron	NM_007149	NP_009080			zinc finger protein 184						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1																		---	---	---	---
HIST1H4K	8362	broad.mit.edu	37	6	27799470	27799470	+	5'Flank	DEL	A	-	-	rs71559051		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:27799470delA	uc003njr.2	-							NM_003541	NP_003532			histone cluster 1, H4k						CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding				0																		---	---	---	---
HIST1H1B	3009	broad.mit.edu	37	6	27835239	27835241	+	In_Frame_Del	DEL	CTT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:27835239_27835241delCTT	uc003njx.2	-	1	119_121	c.67_69delAAG	c.(67-69)AAGdel	p.K23del		NM_005322	NP_005313	P16401	H15_HUMAN	histone cluster 1, H1b	23					nucleosome assembly	nucleosome|nucleus	DNA binding			large_intestine(2)|lung(1)	3																		---	---	---	---
Unknown	0	broad.mit.edu	37	6	28700477	28700477	+	IGR	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:28700477delG								SCAND3 (145365 upstream) : TRIM27 (170303 downstream)																																			---	---	---	---
TRIM10	10107	broad.mit.edu	37	6	30128035	30128035	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:30128035delA	uc003npo.3	-						TRIM10_uc003npn.2_Intron|TRIM15_uc010jrx.2_5'Flank	NM_006778	NP_006769			tripartite motif-containing 10 isoform 1							cytoplasm	zinc ion binding				0																		---	---	---	---
VARS2	57176	broad.mit.edu	37	6	30893244	30893244	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:30893244delC	uc003nsc.1	+						VARS2_uc011dmx.1_Intron|VARS2_uc011dmy.1_Intron|VARS2_uc011dmz.1_Intron|VARS2_uc011dna.1_Intron|VARS2_uc011dnb.1_Intron|VARS2_uc011dnc.1_Intron|VARS2_uc011dnd.1_Intron|VARS2_uc010jsg.1_Intron|VARS2_uc010jsh.1_Intron	NM_020442	NP_065175			valyl-tRNA synthetase 2, mitochondrial						valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			ovary(3)|central_nervous_system(1)	4																		---	---	---	---
MICA	4276	broad.mit.edu	37	6	31379126	31379128	+	In_Frame_Del	DEL	GAG	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:31379126_31379128delGAG	uc003ntk.1	+	3	642_644	c.603_605delGAG	c.(601-606)CTGAGG>CTG	p.R203del	MICA_uc003rxz.1_In_Frame_Del_p.R65del					RecName: Full=MHC class I polypeptide-related sequence A;          Short=MIC-A; Flags: Precursor;												0		Ovarian(999;0.0253)																---	---	---	---
BAT2	7916	broad.mit.edu	37	6	31593996	31593996	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:31593996delA	uc003nvb.3	+						BAT2_uc011dnv.1_Intron|BAT2_uc003nvc.3_Intron|BAT2_uc003nve.2_3'UTR	NM_080686	NP_542417			HLA-B associated transcript-2							cytoplasm|nucleus	protein binding				0																		---	---	---	---
BAT3	7917	broad.mit.edu	37	6	31610030	31610031	+	Frame_Shift_Ins	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:31610030_31610031insA	uc003nvg.3	-	15	2417_2418	c.2103_2104insT	c.(2101-2106)TTTACCfs	p.F701fs	BAT3_uc003nvf.3_Frame_Shift_Ins_p.F695fs|BAT3_uc003nvh.3_Frame_Shift_Ins_p.F695fs|BAT3_uc003nvi.3_Frame_Shift_Ins_p.F695fs|BAT3_uc011dnw.1_Frame_Shift_Ins_p.F695fs|BAT3_uc011dnx.1_Frame_Shift_Ins_p.F569fs	NM_004639	NP_004630	P46379	BAG6_HUMAN	HLA-B associated transcript-3 isoform a	701_702					apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding				0																		---	---	---	---
VARS	7407	broad.mit.edu	37	6	31749968	31749970	+	Intron	DEL	GGA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:31749968_31749970delGGA	uc003nxe.2	-						VARS_uc003nxf.1_5'Flank|VARS_uc011doi.1_Intron	NM_006295	NP_006286			valyl-tRNA synthetase						translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3					L-Valine(DB00161)													---	---	---	---
CYP21A2	1589	broad.mit.edu	37	6	32006625	32006625	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:32006625delT	uc003nze.1	+						CYP21A2_uc003nzf.1_Intron	NM_000500	NP_000491			cytochrome P450, family 21, subfamily A,						glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|steroid 21-monooxygenase activity|steroid binding				0																		---	---	---	---
TAP1	6890	broad.mit.edu	37	6	32819684	32819685	+	Intron	INS	-	TG	TG	rs141273059	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:32819684_32819685insTG	uc003ocg.2	-						TAP1_uc011dqi.1_Intron|PSMB9_uc011dqj.1_5'Flank|PSMB9_uc003sga.2_5'Flank	NM_000593	NP_000584			transporter 1, ATP-binding cassette, sub-family						antigen processing and presentation of endogenous peptide antigen via MHC class I|cytosol to ER transport|intracellular transport of viral proteins in host cell|positive regulation of T cell mediated cytotoxicity	cytosol|plasma membrane|TAP complex	ADP binding|ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding			skin(1)	1																		---	---	---	---
HLA-DPB1	3115	broad.mit.edu	37	6	33052581	33052592	+	Intron	DEL	AAAGAAAGAATG	-	-	rs9280308		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:33052581_33052592delAAAGAAAGAATG	uc003ocu.1	+						HLA-DPB1_uc011dqo.1_Intron|HLA-DPB1_uc011dqp.1_Intron|HLA-DPB1_uc011dqq.1_Intron	NM_002121	NP_002112			major histocompatibility complex, class II, DP						antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to membrane|lysosomal membrane|MHC class II protein complex				ovary(1)	1																		---	---	---	---
VPS52	6293	broad.mit.edu	37	6	33219119	33219119	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:33219119delA	uc003odm.1	-						VPS52_uc003odn.1_Intron	NM_022553	NP_072047			vacuolar protein sorting 52						protein transport	endosome membrane|Golgi apparatus				ovary(4)|skin(1)	5																		---	---	---	---
RPL10A	4736	broad.mit.edu	37	6	35438232	35438232	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:35438232delT	uc003okp.1	+						RPL10A_uc003okq.1_Intron|RPL10A_uc003okr.1_Intron|RPL10A_uc003oks.1_Intron	NM_007104	NP_009035			ribosomal protein L10a						anatomical structure morphogenesis|endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|large ribosomal subunit	RNA binding|structural constituent of ribosome			ovary(1)	1																		---	---	---	---
FKBP5	2289	broad.mit.edu	37	6	35554625	35554625	+	Intron	DEL	T	-	-	rs112376611		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:35554625delT	uc011dte.1	-						FKBP5_uc003okx.2_Intron|FKBP5_uc011dtf.1_Intron|FKBP5_uc003oky.2_Intron|FKBP5_uc003okz.2_3'UTR	NM_001145776	NP_001139248			FK506 binding protein 5 isoform 1						protein folding	cytoplasm|membrane|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity			ovary(1)	1																		---	---	---	---
SLC26A8	116369	broad.mit.edu	37	6	35959378	35959378	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:35959378delT	uc003olm.2	-						SLC26A8_uc003oln.2_Intron|SLC26A8_uc003oll.2_Intron	NM_052961	NP_443193			solute carrier family 26, member 8 isoform a						cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			ovary(2)	2																		---	---	---	---
ETV7	51513	broad.mit.edu	37	6	36355210	36355210	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:36355210delA	uc003omb.2	-						ETV7_uc003olz.1_Intron|ETV7_uc003oma.1_Intron|ETV7_uc010jwg.2_Intron|ETV7_uc003omc.2_Intron|ETV7_uc010jwj.2_Intron|ETV7_uc010jwh.2_Intron|ETV7_uc010jwi.2_Intron|ETV7_uc011dtl.1_Intron	NM_016135	NP_057219			ets variant 7						organ morphogenesis|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2																		---	---	---	---
KCTD20	222658	broad.mit.edu	37	6	36442433	36442433	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:36442433delT	uc003ome.2	+						KCTD20_uc011dtm.1_Intron|KCTD20_uc011dtn.1_Intron|KCTD20_uc010jwk.2_Intron|KCTD20_uc011dto.1_Intron	NM_173562	NP_775833			potassium channel tetramerisation domain							voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)	2																		---	---	---	---
TBC1D22B	55633	broad.mit.edu	37	6	37254720	37254721	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:37254720_37254721insA	uc003onn.2	+						TBC1D22B_uc010jwt.2_Intron	NM_017772	NP_060242			TBC1 domain family, member 22B							intracellular	Rab GTPase activator activity				0			OV - Ovarian serous cystadenocarcinoma(102;0.241)															---	---	---	---
DNAH8	1769	broad.mit.edu	37	6	38770842	38770842	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:38770842delT	uc003ooe.1	+							NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21																		---	---	---	---
UNC5CL	222643	broad.mit.edu	37	6	41028896	41028907	+	Intron	DEL	TTTTTTTTTTTT	-	-	rs35586672		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:41028896_41028907delTTTTTTTTTTTT	uc010jxe.1	-						APOBEC2_uc003opl.2_Intron|APOBEC2_uc010jxf.2_Intron	NM_173561	NP_775832			unc-5 homolog C-like						signal transduction	cytoplasm|integral to membrane				ovary(2)	2	Ovarian(28;0.0418)|Colorectal(47;0.196)																	---	---	---	---
TREML3	340206	broad.mit.edu	37	6	41185829	41185829	+	5'Flank	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:41185829delT	uc003oqb.2	-							NR_027256				Homo sapiens TREM-like transcript 3 (TLT3) mRNA, partial cds.												0																		---	---	---	---
TRERF1	55809	broad.mit.edu	37	6	42233562	42233562	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:42233562delA	uc003osd.2	-						TRERF1_uc011duq.1_Intron|TRERF1_uc003osb.2_Intron|TRERF1_uc003osc.2_Intron|TRERF1_uc003ose.2_Intron	NM_033502	NP_277037			transcriptional regulating factor 1						cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)															---	---	---	---
UBR2	23304	broad.mit.edu	37	6	42643695	42643695	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:42643695delA	uc011dur.1	+						UBR2_uc011dus.1_Intron|UBR2_uc003osh.2_Intron|UBR2_uc011dut.1_Intron	NM_015255	NP_056070			ubiquitin protein ligase E3 component n-recognin						cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			ovary(3)|pancreas(1)	4	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)															---	---	---	---
UBR2	23304	broad.mit.edu	37	6	42652345	42652345	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:42652345delA	uc011dur.1	+						UBR2_uc011dus.1_Intron|UBR2_uc003osh.2_Intron|UBR2_uc011dut.1_Intron|UBR2_uc011duu.1_5'Flank	NM_015255	NP_056070			ubiquitin protein ligase E3 component n-recognin						cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			ovary(3)|pancreas(1)	4	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)															---	---	---	---
XPO5	57510	broad.mit.edu	37	6	43498260	43498260	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:43498260delT	uc003ovp.2	-							NM_020750	NP_065801			exportin 5						gene silencing by RNA	cytosol|nucleoplasm	protein binding|tRNA binding			skin(2)|breast(1)|kidney(1)	4	all_cancers(18;2.08e-05)|Lung NSC(15;0.000907)|all_lung(25;0.00243)		all cancers(41;0.000321)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0524)															---	---	---	---
CAPN11	11131	broad.mit.edu	37	6	44145055	44145057	+	In_Frame_Del	DEL	TGT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:44145055_44145057delTGT	uc003owt.1	+	12	1352_1354	c.1314_1316delTGT	c.(1312-1317)AATGTT>AAT	p.V441del	CAPN11_uc011dvn.1_In_Frame_Del_p.V95del	NM_007058	NP_008989	Q9UMQ6	CAN11_HUMAN	calpain 11	441	Domain III.				proteolysis	acrosomal vesicle	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			ovary(1)|breast(1)	2	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)															---	---	---	---
CDC5L	988	broad.mit.edu	37	6	44361410	44361410	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:44361410delT	uc003oxl.2	+							NM_001253	NP_001244			CDC5-like						cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|cytoplasm|nuclear speck|nucleolus	DNA binding|RNA binding			lung(3)|ovary(1)|kidney(1)|skin(1)	6	all_lung(25;0.00433)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)															---	---	---	---
SUPT3H	8464	broad.mit.edu	37	6	45296016	45296016	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:45296016delA	uc003oxo.2	-						SUPT3H_uc003oxn.1_Intron|SUPT3H_uc011dvv.1_Intron|SUPT3H_uc003oxp.2_Intron|RUNX2_uc011dvx.1_5'Flank|RUNX2_uc011dvy.1_5'Flank|RUNX2_uc003oxs.1_5'Flank	NM_181356	NP_852001			suppressor of Ty 3 homolog isoform 2						histone deubiquitination|histone H3 acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	STAGA complex|transcription factor TFTC complex	DNA binding|transcription coactivator activity			ovary(2)|breast(1)	3																		---	---	---	---
RUNX2	860	broad.mit.edu	37	6	45479855	45479856	+	Intron	DEL	TA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:45479855_45479856delTA	uc011dvx.1	+						RUNX2_uc011dvy.1_Intron|RUNX2_uc003oxt.2_Intron	NM_001024630	NP_001019801			runt-related transcription factor 2 isoform a						negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3																		---	---	---	---
ENPP5	59084	broad.mit.edu	37	6	46135796	46135796	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:46135796delA	uc003oxz.1	-	2	412	c.204delT	c.(202-204)TTTfs	p.F68fs	ENPP5_uc003oya.1_Frame_Shift_Del_p.F68fs|ENPP5_uc011dvz.1_Intron|ENPP5_uc010jzc.1_Frame_Shift_Del_p.F68fs	NM_021572	NP_067547	Q9UJA9	ENPP5_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	68						extracellular region|integral to membrane	hydrolase activity				0																		---	---	---	---
CD2AP	23607	broad.mit.edu	37	6	47512554	47512554	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:47512554delA	uc003oyw.2	+							NM_012120	NP_036252			CD2-associated protein						cell division|mitosis|protein complex assembly|signal transduction|substrate-dependent cell migration, cell extension	cytoplasm|filamentous actin|nucleolus|plasma membrane|ruffle	SH3 domain binding|structural constituent of cytoskeleton			ovary(1)|skin(1)	2			Lung(136;0.105)|LUSC - Lung squamous cell carcinoma(51;0.138)															---	---	---	---
MUT	4594	broad.mit.edu	37	6	49408202	49408202	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:49408202delT	uc003ozg.3	-							NM_000255	NP_000246			methylmalonyl Coenzyme A mutase precursor						fatty acid beta-oxidation	mitochondrial matrix	cobalamin binding|metal ion binding|methylmalonyl-CoA mutase activity				0	Lung NSC(77;0.0376)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)													---	---	---	---
IL17A	3605	broad.mit.edu	37	6	52053677	52053678	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:52053677_52053678insA	uc003pak.1	+							NM_002190	NP_002181			interleukin 17A precursor						apoptosis|cell-cell signaling|fibroblast activation|immune response|inflammatory response|positive regulation of interleukin-23 production|positive regulation of osteoclast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein glycosylation	extracellular space	cytokine activity				0	Lung NSC(77;0.116)																	---	---	---	---
Unknown	0	broad.mit.edu	37	6	52677321	52677321	+	IGR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:52677321delA								GSTA1 (8657 upstream) : GSTA5 (19220 downstream)																																			---	---	---	---
GSTA3	2940	broad.mit.edu	37	6	52765063	52765064	+	Intron	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:52765063_52765064delTT	uc003pbb.2	-						GSTA3_uc010jzq.2_Intron	NM_000847	NP_000838			glutathione S-transferase alpha 3						glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity				0	Lung NSC(77;0.0912)				Glutathione(DB00143)													---	---	---	---
KLHL31	401265	broad.mit.edu	37	6	53520114	53520114	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:53520114delA	uc003pcb.3	-							NM_001003760	NP_001003760			kelch repeat and BTB (POZ) domain containing 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent					ovary(1)	1	Lung NSC(77;0.0158)																	---	---	---	---
COL21A1	81578	broad.mit.edu	37	6	55934015	55934015	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:55934015delA	uc003pcs.2	-						COL21A1_uc010jzz.2_Intron|COL21A1_uc011dxg.1_Intron|COL21A1_uc011dxh.1_Intron|COL21A1_uc003pcr.2_Intron	NM_030820	NP_110447			collagen, type XXI, alpha 1 precursor						cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(2)	2	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)															---	---	---	---
DST	667	broad.mit.edu	37	6	56765014	56765015	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:56765014_56765015insT	uc003pdf.2	-							NM_001144769	NP_001138241			dystonin isoform 2						cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)															---	---	---	---
BEND6	221336	broad.mit.edu	37	6	56869465	56869465	+	Intron	DEL	A	-	-	rs113372809		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:56869465delA	uc010kab.2	+						BEND6_uc003pdg.2_Intron	NM_152731	NP_689944			BEN domain containing 6												0																		---	---	---	---
RAB23	51715	broad.mit.edu	37	6	57074850	57074850	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:57074850delA	uc003pds.2	-						RAB23_uc003pdt.2_Intron|RAB23_uc010kac.2_Intron|RAB23_uc010kad.2_Intron	NM_183227	NP_899050			Ras-related protein Rab-23						protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			skin(1)	1	Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)															---	---	---	---
Unknown	0	broad.mit.edu	37	6	64326153	64326153	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:64326153delT								PTP4A1 (32665 upstream) : PHF3 (19572 downstream)																																			---	---	---	---
PHF3	23469	broad.mit.edu	37	6	64413280	64413280	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:64413280delA	uc003pep.1	+						PHF3_uc010kah.1_Intron|PHF3_uc003pen.2_Intron|PHF3_uc011dxs.1_Intron	NM_015153	NP_055968			PHD finger protein 3						multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)															---	---	---	---
COL9A1	1297	broad.mit.edu	37	6	70972893	70972893	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:70972893delA	uc003pfg.3	-						COL9A1_uc003pfe.3_Intron|COL9A1_uc003pff.3_Intron	NM_001851	NP_001842			alpha 1 type IX collagen isoform 1 precursor						axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			ovary(4)	4																		---	---	---	---
COL9A1	1297	broad.mit.edu	37	6	71011893	71011893	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:71011893delT	uc003pfg.3	-							NM_001851	NP_001842			alpha 1 type IX collagen isoform 1 precursor						axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			ovary(4)	4																		---	---	---	---
FAM135A	57579	broad.mit.edu	37	6	71162046	71162046	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:71162046delT	uc003pfj.2	+						FAM135A_uc003pfi.2_Intron|FAM135A_uc003pfh.2_Intron|FAM135A_uc003pfk.2_Intron|FAM135A_uc003pfl.2_Intron	NM_001162529	NP_001156001			hypothetical protein LOC57579 isoform c											central_nervous_system(1)	1																		---	---	---	---
FAM135A	57579	broad.mit.edu	37	6	71235557	71235558	+	Frame_Shift_Ins	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:71235557_71235558insT	uc003pfj.2	+	13	2903_2904	c.2770_2771insT	c.(2770-2772)GTTfs	p.V924fs	FAM135A_uc003pfi.2_Frame_Shift_Ins_p.V728fs|FAM135A_uc003pfh.2_Frame_Shift_Ins_p.V711fs|FAM135A_uc003pfl.2_Frame_Shift_Ins_p.V591fs|FAM135A_uc003pfn.2_Intron|FAM135A_uc003pfo.1_Frame_Shift_Ins_p.V295fs|FAM135A_uc010kan.1_5'Flank	NM_001162529	NP_001156001	Q9P2D6	F135A_HUMAN	hypothetical protein LOC57579 isoform c	924										central_nervous_system(1)	1																		---	---	---	---
SMAP1	60682	broad.mit.edu	37	6	71508370	71508370	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:71508370delA	uc003pfr.2	+	6	754	c.506delA	c.(505-507)GAAfs	p.E169fs	SMAP1_uc011dxy.1_RNA|SMAP1_uc003pfs.2_Frame_Shift_Del_p.E142fs|SMAP1_uc010kao.2_Frame_Shift_Del_p.E142fs|SMAP1_uc010kap.2_Frame_Shift_Del_p.E159fs	NM_001044305	NP_001037770	Q8IYB5	SMAP1_HUMAN	stromal membrane-associated GTPase-activating	169					regulation of ARF GTPase activity	plasma membrane	ARF GTPase activator activity|zinc ion binding				0																		---	---	---	---
COL12A1	1303	broad.mit.edu	37	6	75851597	75851598	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:75851597_75851598insA	uc003phs.2	-						COL12A1_uc003pht.2_Intron	NM_004370	NP_004361			collagen, type XII, alpha 1 long isoform						cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9																		---	---	---	---
FILIP1	27145	broad.mit.edu	37	6	76072773	76072773	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:76072773delT	uc003pia.2	-						FILIP1_uc003phy.1_Intron|FILIP1_uc003phz.2_5'Flank|FILIP1_uc010kbe.2_Intron	NM_015687	NP_056502			filamin A interacting protein 1											skin(3)|ovary(1)	4																		---	---	---	---
SENP6	26054	broad.mit.edu	37	6	76343130	76343130	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:76343130delA	uc003pid.3	+						SENP6_uc003pie.3_Intron|SENP6_uc003pic.2_Intron|SENP6_uc003pif.1_5'Flank	NM_015571	NP_056386			SUMO1/sentrin specific peptidase 6 isoform 1						proteolysis	cytoplasm|nucleus	cysteine-type peptidase activity			breast(2)|urinary_tract(1)|ovary(1)|lung(1)|skin(1)	6		all_hematologic(105;0.189)																---	---	---	---
MYO6	4646	broad.mit.edu	37	6	76542706	76542706	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:76542706delT	uc003pih.1	+						MYO6_uc003pig.1_Intron|MYO6_uc003pii.1_Intron	NM_004999	NP_004990			myosin VI						actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			kidney(1)|pancreas(1)	2		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)														---	---	---	---
MYO6	4646	broad.mit.edu	37	6	76576840	76576840	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:76576840delT	uc003pih.1	+						MYO6_uc003pig.1_Intron|MYO6_uc003pii.1_Intron	NM_004999	NP_004990			myosin VI						actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			kidney(1)|pancreas(1)	2		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)														---	---	---	---
IMPG1	3617	broad.mit.edu	37	6	76751759	76751760	+	Frame_Shift_Ins	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:76751759_76751760insT	uc003pik.1	-	2	281_282	c.151_152insA	c.(151-153)ATGfs	p.M51fs		NM_001563	NP_001554	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	51					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)																---	---	---	---
PHIP	55023	broad.mit.edu	37	6	79679504	79679504	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:79679504delA	uc003pir.2	-						PHIP_uc003piq.2_Intron|PHIP_uc011dyp.1_Intron	NM_017934	NP_060404			pleckstrin homology domain interacting protein						insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	6		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)														---	---	---	---
PHIP	55023	broad.mit.edu	37	6	79708254	79708254	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:79708254delA	uc003pir.2	-						PHIP_uc011dyp.1_Intron	NM_017934	NP_060404			pleckstrin homology domain interacting protein						insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	6		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)														---	---	---	---
PHIP	55023	broad.mit.edu	37	6	79735062	79735062	+	Intron	DEL	A	-	-	rs75034739		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:79735062delA	uc003pir.2	-						PHIP_uc011dyp.1_Intron	NM_017934	NP_060404			pleckstrin homology domain interacting protein						insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	6		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)														---	---	---	---
BCKDHB	594	broad.mit.edu	37	6	80880979	80880979	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:80880979delA	uc003pjd.2	+						BCKDHB_uc003pje.2_Intron	NM_000056	NP_000047			branched chain keto acid dehydrogenase E1 beta						branched chain family amino acid catabolic process	mitochondrial alpha-ketoglutarate dehydrogenase complex	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|carboxy-lyase activity|protein binding				0		all_cancers(76;1.38e-05)|Acute lymphoblastic leukemia(125;1.15e-05)|all_hematologic(105;0.00118)|all_epithelial(107;0.0149)		BRCA - Breast invasive adenocarcinoma(397;0.0291)														---	---	---	---
IBTK	25998	broad.mit.edu	37	6	82925973	82925973	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:82925973delA	uc003pjl.1	-						IBTK_uc011dyv.1_Intron|IBTK_uc011dyw.1_Intron|IBTK_uc010kbi.1_Intron|IBTK_uc003pjm.2_Intron	NM_015525	NP_056340			inhibitor of Bruton's tyrosine kinase						negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity			ovary(2)|central_nervous_system(2)	4		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)														---	---	---	---
NT5E	4907	broad.mit.edu	37	6	86200696	86200696	+	Intron	DEL	T	-	-	rs78785302		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:86200696delT	uc003pko.3	+						NT5E_uc010kbr.2_Intron	NM_002526	NP_002517			5' nucleotidase, ecto precursor						DNA metabolic process|purine base metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	anchored to membrane|cytoplasm|membrane fraction|plasma membrane	5'-nucleotidase activity|nucleotide binding			ovary(3)|central_nervous_system(1)	4		all_cancers(76;0.000215)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0427)		BRCA - Breast invasive adenocarcinoma(108;0.0417)	Pentoxifylline(DB00806)													---	---	---	---
C6orf165	154313	broad.mit.edu	37	6	88125702	88125703	+	Intron	DEL	AA	-	-	rs34892535		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:88125702_88125703delAA	uc003plv.2	+						C6orf165_uc003plw.2_Intron|C6orf165_uc010kbv.1_Intron|C6orf165_uc003plu.1_Intron	NM_001031743	NP_001026913			hypothetical protein LOC154313 isoform 1											central_nervous_system(1)	1		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)														---	---	---	---
SLC35A1	10559	broad.mit.edu	37	6	88220956	88220957	+	Intron	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:88220956_88220957delTT	uc011dzj.1	+						SLC35A1_uc003plx.2_Intron|SLC35A1_uc010kbw.2_Intron|SLC35A1_uc003plz.2_Intron|SLC35A1_uc011dzi.1_Intron|SLC35A1_uc003ply.2_Intron|SLC35A1_uc010kbx.2_Intron|SLC35A1_uc010kby.2_Intron	NM_006416	NP_006407			solute carrier family 35 (CMP-sialic acid						carbohydrate metabolic process|protein modification process	Golgi membrane|integral to plasma membrane	CMP-N-acetylneuraminate transmembrane transporter activity|sugar:hydrogen symporter activity				0		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0429)														---	---	---	---
RNGTT	8732	broad.mit.edu	37	6	89614294	89614294	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:89614294delT	uc003pmr.2	-						RNGTT_uc003pms.2_Intron|RNGTT_uc011dzu.1_Intron|RNGTT_uc003pmt.2_Intron	NM_003800	NP_003791			RNA guanylyltransferase and 5'-phosphatase						interspecies interaction between organisms|mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	GTP binding|mRNA guanylyltransferase activity|polynucleotide 5'-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			upper_aerodigestive_tract(1)	1		all_cancers(76;4.07e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;6.86e-05)		BRCA - Breast invasive adenocarcinoma(108;0.151)														---	---	---	---
GABRR1	2569	broad.mit.edu	37	6	89888937	89888937	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:89888937delT	uc003pna.2	-						GABRR1_uc011dzv.1_Intron	NM_002042	NP_002033			gamma-aminobutyric acid (GABA) receptor, rho 1						gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			pancreas(1)	1		all_cancers(76;9.49e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.46e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00917)	Picrotoxin(DB00466)													---	---	---	---
GABRR1	2569	broad.mit.edu	37	6	89912986	89912986	+	Intron	DEL	G	-	-	rs4457138	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:89912986delG	uc003pna.2	-						GABRR1_uc011dzv.1_Intron	NM_002042	NP_002033			gamma-aminobutyric acid (GABA) receptor, rho 1						gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			pancreas(1)	1		all_cancers(76;9.49e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.46e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00917)	Picrotoxin(DB00466)													---	---	---	---
UBE2J1	51465	broad.mit.edu	37	6	90039279	90039279	+	3'UTR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:90039279delA	uc010kcb.2	-	9					UBE2J1_uc003pnc.2_3'UTR	NM_016021	NP_057105			ubiquitin-conjugating enzyme E2, J1							endoplasmic reticulum membrane|integral to membrane	ATP binding|ubiquitin-protein ligase activity				0		all_cancers(76;1.65e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;2.5e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0139)														---	---	---	---
MDN1	23195	broad.mit.edu	37	6	90374456	90374456	+	Intron	DEL	A	-	-	rs3818133	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:90374456delA	uc003pnn.1	-							NM_014611	NP_055426			MDN1, midasin homolog						protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)														---	---	---	---
CASP8AP2	9994	broad.mit.edu	37	6	90571823	90571823	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:90571823delT	uc003pnr.2	+						CASP8AP2_uc003pns.2_Intron|CASP8AP2_uc003pnt.2_Intron|CASP8AP2_uc011dzz.1_Intron	NM_001137667	NP_001131139			caspase 8 associated protein 2						cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			ovary(2)	2		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)														---	---	---	---
CASP8AP2	9994	broad.mit.edu	37	6	90583371	90583372	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:90583371_90583372insT	uc003pnr.2	+						CASP8AP2_uc003pnt.2_Intron|CASP8AP2_uc011dzz.1_Intron	NM_001137667	NP_001131139			caspase 8 associated protein 2						cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			ovary(2)	2		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)														---	---	---	---
FHL5	9457	broad.mit.edu	37	6	97051249	97051249	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:97051249delT	uc003pos.1	+						FHL5_uc003pot.1_Intron	NM_020482	NP_065228			activator of cAMP-responsive element modulator							nucleus	zinc ion binding			ovary(2)	2		all_cancers(76;1.57e-07)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00266)|Colorectal(196;0.0341)|Lung NSC(302;0.204)		BRCA - Breast invasive adenocarcinoma(108;0.0948)														---	---	---	---
C6orf167	253714	broad.mit.edu	37	6	97715988	97715988	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:97715988delT	uc003ppb.2	-						C6orf167_uc011eaf.1_Intron|C6orf167_uc010kcn.1_Intron|C6orf167_uc010kco.1_Intron|C6orf167_uc003ppc.2_Intron	NM_198468	NP_940870			hypothetical protein LOC253714						double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding				0		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.148)|Colorectal(196;0.198)		BRCA - Breast invasive adenocarcinoma(108;0.0457)														---	---	---	---
USP45	85015	broad.mit.edu	37	6	99893659	99893659	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:99893659delA	uc003ppx.2	-						USP45_uc003ppv.2_Intron|USP45_uc003ppw.2_Intron	NM_001080481	NP_001073950			ubiquitin specific peptidase 45						ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|breast(1)	2		all_cancers(76;0.000208)|Acute lymphoblastic leukemia(125;8.41e-11)|all_hematologic(75;2.56e-07)|all_epithelial(107;0.122)|Colorectal(196;0.133)		BRCA - Breast invasive adenocarcinoma(108;0.0718)														---	---	---	---
ASCC3	10973	broad.mit.edu	37	6	101100773	101100773	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:101100773delA	uc003pqk.2	-						ASCC3_uc011eai.1_Intron	NM_006828	NP_006819			activating signal cointegrator 1 complex subunit						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)														---	---	---	---
HACE1	57531	broad.mit.edu	37	6	105281214	105281214	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:105281214delT	uc003pqu.1	-						HACE1_uc010kcy.1_Intron|HACE1_uc010kcz.1_Intron	NM_020771	NP_065822			HECT domain and ankyrin repeat containing, E3						protein ubiquitination involved in ubiquitin-dependent protein catabolic process	endoplasmic reticulum	ubiquitin-protein ligase activity			ovary(5)|lung(2)	7		all_cancers(87;6.89e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0216)|Colorectal(196;0.202)		BRCA - Breast invasive adenocarcinoma(108;0.122)|Epithelial(106;0.204)														---	---	---	---
ATG5	9474	broad.mit.edu	37	6	106764250	106764250	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:106764250delA	uc003prf.2	-						ATG5_uc010kdb.2_Intron|ATG5_uc003prg.2_Intron|ATG5_uc010kdc.2_Intron	NM_004849	NP_004840			APG5 autophagy 5-like						apoptosis|autophagic vacuole assembly|negative regulation of type I interferon production|post-translational protein modification	autophagic vacuole|pre-autophagosomal structure membrane	protein binding			large_intestine(1)	1	Breast(9;0.0296)	all_cancers(87;0.000301)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.0612)|Lung NSC(302;0.216)	BRCA - Breast invasive adenocarcinoma(8;0.00802)	OV - Ovarian serous cystadenocarcinoma(136;0.128)|Epithelial(106;0.159)|all cancers(137;0.18)														---	---	---	---
PDSS2	57107	broad.mit.edu	37	6	107780431	107780431	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:107780431delG	uc003prt.2	-	1	349	c.59delC	c.(58-60)CCGfs	p.P20fs	PDSS2_uc011eak.1_Intron|PDSS2_uc011eal.1_Frame_Shift_Del_p.P20fs|PDSS2_uc003pru.2_Frame_Shift_Del_p.P20fs|PDSS2_uc003prv.2_Frame_Shift_Del_p.P20fs	NM_020381	NP_065114	Q86YH6	DLP1_HUMAN	prenyl diphosphate synthase, subunit 2	20					isoprenoid biosynthetic process|ubiquinone biosynthetic process	mitochondrion	protein heterodimerization activity			ovary(2)	2	Breast(9;0.0127)	all_cancers(87;3.63e-05)|Acute lymphoblastic leukemia(125;2.86e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.0108)|Colorectal(196;0.156)|Lung NSC(302;0.211)	BRCA - Breast invasive adenocarcinoma(8;0.0101)|all cancers(7;0.243)	BRCA - Breast invasive adenocarcinoma(108;0.112)|OV - Ovarian serous cystadenocarcinoma(136;0.173)|all cancers(137;0.191)												OREG0017595	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
FOXO3	2309	broad.mit.edu	37	6	108985249	108985249	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:108985249delG	uc003psk.2	+	3	1529	c.1213delG	c.(1213-1215)GGGfs	p.G405fs	FOXO3_uc003psn.2_Intron|FOXO3_uc003psm.2_Frame_Shift_Del_p.G405fs|FOXO3_uc011ean.1_Frame_Shift_Del_p.G185fs|FOXO3_uc010kdj.1_Frame_Shift_Del_p.G185fs	NM_201559	NP_963853	O43524	FOXO3_HUMAN	forkhead box O3A	405					antral ovarian follicle growth|apoptosis|embryo development|glucose homeostasis|induction of apoptosis|initiation of primordial ovarian follicle growth|insulin receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|oocyte maturation|ovulation from ovarian follicle|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			central_nervous_system(4)|lung(2)	6		all_cancers(87;1.78e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;3.88e-05)|Colorectal(196;0.0294)|all_lung(197;0.0487)|Lung SC(18;0.152)		Epithelial(106;0.000759)|all cancers(137;0.00121)|BRCA - Breast invasive adenocarcinoma(108;0.00163)|OV - Ovarian serous cystadenocarcinoma(136;0.00718)														---	---	---	---
SESN1	27244	broad.mit.edu	37	6	109309010	109309011	+	Intron	DEL	TT	-	-	rs35465901		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:109309010_109309011delTT	uc003pst.3	-						SESN1_uc003psu.2_Intron	NM_014454	NP_055269			sestrin 1						cell cycle arrest|negative regulation of cell proliferation|response to DNA damage stimulus	nucleus				ovary(1)	1		all_cancers(87;6.45e-05)|Acute lymphoblastic leukemia(125;3.55e-10)|all_hematologic(75;1.68e-07)|all_epithelial(87;0.0106)|Colorectal(196;0.0637)		Epithelial(106;0.0014)|BRCA - Breast invasive adenocarcinoma(108;0.00146)|all cancers(137;0.0031)|OV - Ovarian serous cystadenocarcinoma(136;0.0117)														---	---	---	---
C6orf182	285753	broad.mit.edu	37	6	109476974	109476975	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:109476974_109476975insT	uc010kdk.2	+						C6orf182_uc003psv.3_Intron|C6orf182_uc003psw.3_Intron|C6orf182_uc003psx.3_Intron|C6orf182_uc010kdl.2_Intron|C6orf182_uc003psy.3_Intron	NM_001083535	NP_001077004			hypothetical protein LOC285753							microtubule|microtubule organizing center					0		all_cancers(87;4.45e-07)|Acute lymphoblastic leukemia(125;2.15e-10)|all_hematologic(75;3.25e-08)|all_epithelial(87;0.000254)|Colorectal(196;0.0293)|all_lung(197;0.11)		BRCA - Breast invasive adenocarcinoma(108;0.00123)|Epithelial(106;0.0022)|all cancers(137;0.00405)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)														---	---	---	---
FIG4	9896	broad.mit.edu	37	6	110086430	110086431	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:110086430_110086431insT	uc003ptt.2	+						FIG4_uc011eau.1_Intron	NM_014845	NP_055660			Sac domain-containing inositol phosphatase 3						cell death	endosome membrane	protein binding			ovary(1)	1		all_cancers(87;8.63e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000124)|all_lung(197;0.0187)|Colorectal(196;0.0492)|Lung SC(18;0.0548)		OV - Ovarian serous cystadenocarcinoma(136;0.0355)|Epithelial(106;0.038)|all cancers(137;0.0425)|BRCA - Breast invasive adenocarcinoma(108;0.079)														---	---	---	---
WASF1	8936	broad.mit.edu	37	6	110423574	110423575	+	Intron	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:110423574_110423575delAA	uc003ptv.1	-						WASF1_uc003ptw.1_Intron|WASF1_uc003ptx.1_Intron|WASF1_uc003pty.1_Intron	NM_003931	NP_003922			Wiskott-Aldrich syndrome protein family member						actin filament polymerization|cellular component movement	actin cytoskeleton	actin binding				0		all_cancers(87;1.18e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		OV - Ovarian serous cystadenocarcinoma(136;0.0364)|Epithelial(106;0.051)|all cancers(137;0.0687)														---	---	---	---
CDC40	51362	broad.mit.edu	37	6	110538710	110538710	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:110538710delA	uc003pua.2	+							NM_015891	NP_056975			cell division cycle 40 homolog						mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm					0		all_cancers(87;6.23e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		Epithelial(106;0.0221)|all cancers(137;0.0314)|OV - Ovarian serous cystadenocarcinoma(136;0.034)														---	---	---	---
AMD1	262	broad.mit.edu	37	6	111211425	111211425	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:111211425delT	uc003puk.1	+						AMD1_uc011eay.1_Intron|AMD1_uc011eaz.1_Intron|AMD1_uc011eba.1_Intron|AMD1_uc003pul.1_Intron	NM_001634	NP_001625			adenosylmethionine decarboxylase 1 isoform 1						spermidine biosynthetic process|spermine biosynthetic process	cytosol	adenosylmethionine decarboxylase activity			upper_aerodigestive_tract(1)	1		all_cancers(87;3.83e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0209)		OV - Ovarian serous cystadenocarcinoma(136;0.0522)|Epithelial(106;0.111)|all cancers(137;0.143)	S-Adenosylmethionine(DB00118)													---	---	---	---
KIAA1919	91749	broad.mit.edu	37	6	111583373	111583373	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:111583373delT	uc003puv.3	+							NM_153369	NP_699200			sodium-dependent glucose transporter 1						carbohydrate transport|sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			ovary(3)	3		all_cancers(87;2.35e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.0209)		OV - Ovarian serous cystadenocarcinoma(136;0.055)|all cancers(137;0.0871)|Epithelial(106;0.0884)														---	---	---	---
TRAF3IP2	10758	broad.mit.edu	37	6	111888900	111888900	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:111888900delA	uc011ebc.1	-						TRAF3IP2_uc011ebb.1_5'Flank|TRAF3IP2_uc003pvd.2_Intron|TRAF3IP2_uc003pvg.2_Intron|TRAF3IP2_uc003pvf.2_Intron|TRAF3IP2_uc010kdw.2_Intron	NM_147686	NP_679211			TRAF3 interacting protein 2 isoform 2						intracellular signal transduction|positive regulation of I-kappaB kinase/NF-kappaB cascade	intracellular				ovary(2)|central_nervous_system(1)	3		all_cancers(87;7.87e-06)|Acute lymphoblastic leukemia(125;3.61e-09)|all_hematologic(75;2.63e-07)|all_epithelial(87;0.0024)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.033)|all cancers(137;0.0412)|Epithelial(106;0.0732)														---	---	---	---
TUBE1	51175	broad.mit.edu	37	6	112395885	112395885	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:112395885delA	uc003pvq.2	-						TUBE1_uc003pvr.2_Intron	NM_016262	NP_057346			tubulin, epsilon 1						centrosome cycle|microtubule-based movement|protein polymerization	microtubule|pericentriolar material	GTP binding|GTPase activity|structural constituent of cytoskeleton			ovary(1)	1		all_cancers(87;0.0101)|all_hematologic(75;0.000258)|Colorectal(196;0.0466)|all_epithelial(87;0.1)		all cancers(137;0.0217)|OV - Ovarian serous cystadenocarcinoma(136;0.0613)|Epithelial(106;0.0636)|GBM - Glioblastoma multiforme(226;0.0972)|BRCA - Breast invasive adenocarcinoma(108;0.246)														---	---	---	---
LAMA4	3910	broad.mit.edu	37	6	112450391	112450392	+	Intron	DEL	TG	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:112450391_112450392delTG	uc003pvu.2	-						LAMA4_uc003pvv.2_Intron|LAMA4_uc003pvt.2_Intron	NM_001105206	NP_001098676			laminin, alpha 4 isoform 1 precursor						cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)														---	---	---	---
LAMA4	3910	broad.mit.edu	37	6	112521478	112521478	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:112521478delA	uc003pvu.2	-						LAMA4_uc003pvv.2_Intron|LAMA4_uc003pvt.2_Intron	NM_001105206	NP_001098676			laminin, alpha 4 isoform 1 precursor						cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)														---	---	---	---
Unknown	0	broad.mit.edu	37	6	112937975	112937975	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:112937975delT								RFPL4B (265477 upstream) : None (None downstream)																																			---	---	---	---
GOPC	57120	broad.mit.edu	37	6	117894999	117894999	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:117894999delA	uc003pxu.2	-						GOPC_uc003pxq.1_5'Flank|GOPC_uc003pxv.2_Intron	NM_020399	NP_065132			golgi associated PDZ and coiled-coil motif						apical protein localization|cytoplasmic sequestering of CFTR protein|ER to Golgi vesicle-mediated transport|Golgi to plasma membrane transport|protein homooligomerization|protein transport	cell junction|dendrite|Golgi membrane|postsynaptic density|postsynaptic membrane|trans-Golgi network transport vesicle	cystic fibrosis transmembrane conductance regulator binding			ovary(1)	1		all_cancers(87;0.00844)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0363)|OV - Ovarian serous cystadenocarcinoma(136;0.0821)|all cancers(137;0.0976)				O	ROS1	glioblastoma								---	---	---	---
MCM9	254394	broad.mit.edu	37	6	119245493	119245493	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:119245493delT	uc003pyh.2	-							NM_153255	NP_694987			minichromosome maintenance complex component 9						DNA replication		ATP binding|DNA binding|nucleoside-triphosphatase activity			ovary(1)	1		all_cancers(87;0.122)|all_epithelial(87;0.179)		GBM - Glioblastoma multiforme(226;0.0676)|OV - Ovarian serous cystadenocarcinoma(136;0.194)														---	---	---	---
CLVS2	134829	broad.mit.edu	37	6	123376954	123376954	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:123376954delT	uc003pzi.1	+	5	1548	c.679delT	c.(679-681)TTTfs	p.F227fs		NM_001010852	NP_001010852	Q5SYC1	CLVS2_HUMAN	retinaldehyde binding protein 1-like 2	227	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5																		---	---	---	---
TRDN	10345	broad.mit.edu	37	6	123786033	123786033	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:123786033delA	uc003pzj.1	-						TRDN_uc003pzk.1_Intron|TRDN_uc003pzl.1_Intron|TRDN_uc010ken.2_Frame_Shift_Del_p.S297fs|uc003pzm.1_Intron	NM_006073	NP_006064			triadin						muscle contraction	integral to membrane|plasma membrane|sarcoplasmic reticulum membrane	receptor binding			ovary(1)	1				GBM - Glioblastoma multiforme(226;0.184)														---	---	---	---
NKAIN2	154215	broad.mit.edu	37	6	124979215	124979215	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:124979215delA	uc003pzo.2	+						NKAIN2_uc003pzn.1_Intron|NKAIN2_uc003pzp.2_Intron|NKAIN2_uc010keq.2_Intron|NKAIN2_uc010ker.2_Intron	NM_001040214	NP_001035304			T-cell lymphoma breakpoint-associated target 1							integral to membrane|plasma membrane					0				GBM - Glioblastoma multiforme(226;0.104)														---	---	---	---
PTPRK	5796	broad.mit.edu	37	6	128291226	128291226	+	3'UTR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:128291226delA	uc003qbk.2	-	30					PTPRK_uc003qbj.2_3'UTR|PTPRK_uc010kfc.2_3'UTR|PTPRK_uc011ebu.1_3'UTR	NM_002844	NP_002835			protein tyrosine phosphatase, receptor type, K						cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)														---	---	---	---
PTPRK	5796	broad.mit.edu	37	6	128306818	128306818	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:128306818delA	uc003qbk.2	-						PTPRK_uc003qbj.2_Intron|PTPRK_uc010kfc.2_Intron|PTPRK_uc011ebu.1_Intron	NM_002844	NP_002835			protein tyrosine phosphatase, receptor type, K						cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)														---	---	---	---
LAMA2	3908	broad.mit.edu	37	6	129774121	129774121	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:129774121delT	uc003qbn.2	+						LAMA2_uc003qbo.2_Intron	NM_000426	NP_000417			laminin alpha 2 subunit isoform a precursor						cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)														---	---	---	---
LAMA2	3908	broad.mit.edu	37	6	129813416	129813416	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:129813416delA	uc003qbn.2	+						LAMA2_uc003qbo.2_Intron|uc003qbq.2_Intron	NM_000426	NP_000417			laminin alpha 2 subunit isoform a precursor						cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)														---	---	---	---
EPB41L2	2037	broad.mit.edu	37	6	131191315	131191315	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:131191315delA	uc003qch.2	-						EPB41L2_uc003qce.1_Intron|EPB41L2_uc003qcf.1_Intron|EPB41L2_uc003qcg.1_Intron|EPB41L2_uc011eby.1_Intron|EPB41L2_uc003qci.2_Intron|EPB41L2_uc010kfk.2_Intron|EPB41L2_uc010kfl.1_Intron|EPB41L2_uc003qcd.1_5'Flank|EPB41L2_uc003qcj.1_Intron	NM_001431	NP_001422			erythrocyte membrane protein band 4.1-like 2						cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			central_nervous_system(1)|skin(1)	2	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)														---	---	---	---
EPB41L2	2037	broad.mit.edu	37	6	131199420	131199420	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:131199420delA	uc003qch.2	-						EPB41L2_uc003qce.1_Intron|EPB41L2_uc003qcf.1_Intron|EPB41L2_uc003qcg.1_Intron|EPB41L2_uc011eby.1_Intron|EPB41L2_uc003qci.2_Intron|EPB41L2_uc010kfk.2_Intron|EPB41L2_uc010kfl.1_Intron|EPB41L2_uc003qcj.1_5'Flank	NM_001431	NP_001422			erythrocyte membrane protein band 4.1-like 2						cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			central_nervous_system(1)|skin(1)	2	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)														---	---	---	---
C6orf192	116843	broad.mit.edu	37	6	133092454	133092455	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:133092454_133092455insT	uc003qdw.1	-						C6orf192_uc010kgd.1_Intron	NM_052831	NP_439896			hypothetical protein LOC116843						transmembrane transport	integral to membrane				ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(155;0.00303)|GBM - Glioblastoma multiforme(226;0.0265)														---	---	---	---
EYA4	2070	broad.mit.edu	37	6	133846386	133846386	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:133846386delA	uc003qec.3	+	19	2291	c.1833delA	c.(1831-1833)GCAfs	p.A611fs	EYA4_uc011ecq.1_Intron|EYA4_uc011ecr.1_Intron|EYA4_uc003qed.3_Intron|EYA4_uc003qee.3_Frame_Shift_Del_p.A588fs|EYA4_uc011ecs.1_Frame_Shift_Del_p.A617fs|uc003qeg.1_Intron	NM_004100	NP_004091	O95677	EYA4_HUMAN	eyes absent 4 isoform a	611					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			large_intestine(2)	2	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)														---	---	---	---
MAP7	9053	broad.mit.edu	37	6	136684017	136684017	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:136684017delA	uc003qgz.2	-						MAP7_uc011edf.1_Intron|MAP7_uc011edg.1_Intron|MAP7_uc010kgu.2_Intron|MAP7_uc011edh.1_Intron|MAP7_uc010kgv.2_Intron|MAP7_uc010kgs.2_Intron|MAP7_uc011edi.1_Intron|MAP7_uc010kgq.1_Intron|MAP7_uc003qha.1_Intron	NM_003980	NP_003971			microtubule-associated protein 7						establishment or maintenance of cell polarity|microtubule cytoskeleton organization|protein localization in plasma membrane|response to osmotic stress	basolateral plasma membrane|microtubule|microtubule associated complex|nucleus|perinuclear region of cytoplasm	receptor binding|structural molecule activity				0	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00199)|OV - Ovarian serous cystadenocarcinoma(155;0.00643)														---	---	---	---
MAP7	9053	broad.mit.edu	37	6	136732878	136732878	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:136732878delA	uc003qgz.2	-						MAP7_uc011edf.1_Intron|MAP7_uc011edg.1_Intron|MAP7_uc010kgu.2_Intron|MAP7_uc011edh.1_Intron|MAP7_uc010kgv.2_Intron|MAP7_uc010kgs.2_Intron|MAP7_uc011edi.1_Intron|MAP7_uc010kgq.1_Intron|MAP7_uc003qha.1_Intron|MAP7_uc010kgr.2_Intron|MAP7_uc010kgt.2_Intron	NM_003980	NP_003971			microtubule-associated protein 7						establishment or maintenance of cell polarity|microtubule cytoskeleton organization|protein localization in plasma membrane|response to osmotic stress	basolateral plasma membrane|microtubule|microtubule associated complex|nucleus|perinuclear region of cytoplasm	receptor binding|structural molecule activity				0	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00199)|OV - Ovarian serous cystadenocarcinoma(155;0.00643)														---	---	---	---
C6orf115	58527	broad.mit.edu	37	6	139355276	139355276	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:139355276delT	uc003qil.2	+						C6orf115_uc003qim.2_Intron	NM_021243	NP_067066			hypothetical protein LOC58527												0				GBM - Glioblastoma multiforme(68;0.000278)|OV - Ovarian serous cystadenocarcinoma(155;0.000413)														---	---	---	---
GPR126	57211	broad.mit.edu	37	6	142630883	142630884	+	Intron	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:142630883_142630884delTT	uc010khc.2	+						GPR126_uc010khd.2_Intron|GPR126_uc010khe.2_Intron|GPR126_uc010khf.2_Intron|GPR126_uc003qix.2_Intron	NM_020455	NP_065188			G protein-coupled receptor 126 alpha 1						neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)														---	---	---	---
PEX3	8504	broad.mit.edu	37	6	143800376	143800376	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:143800376delA	uc003qjl.2	+							NM_003630	NP_003621			peroxisomal biogenesis factor 3						protein import into peroxisome membrane|transmembrane transport	integral to peroxisomal membrane	protein binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(155;5.73e-06)|GBM - Glioblastoma multiforme(68;0.0117)														---	---	---	---
PHACTR2	9749	broad.mit.edu	37	6	144109707	144109707	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:144109707delT	uc003qjq.3	+						PHACTR2_uc010khh.2_Intron|PHACTR2_uc010khi.2_Intron|PHACTR2_uc003qjr.3_Intron	NM_014721	NP_055536			phosphatase and actin regulator 2 isoform 3								actin binding|protein phosphatase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(155;1.58e-05)|GBM - Glioblastoma multiforme(68;0.0386)														---	---	---	---
LTV1	84946	broad.mit.edu	37	6	144181842	144181842	+	Intron	DEL	A	-	-	rs138724144	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:144181842delA	uc003qjs.2	+						LTV1_uc003qju.1_Intron|C6orf94_uc010khj.2_Intron	NM_032860	NP_116249			LTV1 homolog											ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(155;2.72e-06)|GBM - Glioblastoma multiforme(68;0.0372)														---	---	---	---
UTRN	7402	broad.mit.edu	37	6	145124398	145124398	+	Intron	DEL	T	-	-	rs71673559		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:145124398delT	uc003qkt.2	+							NM_007124	NP_009055			utrophin						muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)														---	---	---	---
SHPRH	257218	broad.mit.edu	37	6	146244956	146244956	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:146244956delT	uc003qlf.2	-						SHPRH_uc003qld.2_Intron|SHPRH_uc003qle.2_Intron|SHPRH_uc003qlg.1_Intron|SHPRH_uc003qlh.2_Intron|SHPRH_uc003qli.1_Intron	NM_001042683	NP_001036148			SNF2 histone linker PHD RING helicase isoform a						DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)														---	---	---	---
RAET1K	646024	broad.mit.edu	37	6	150321860	150321860	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:150321860delC	uc003qnq.2	-							NR_024045				Homo sapiens RAET1K mRNA, partial sequence.												0																		---	---	---	---
C6orf211	79624	broad.mit.edu	37	6	151773568	151773568	+	5'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:151773568delT	uc003qok.1	+	1					C6orf211_uc011ees.1_5'UTR|RMND1_uc003qoi.2_5'Flank	NM_024573	NP_078849			hypothetical protein LOC79624								protein binding				0			BRCA - Breast invasive adenocarcinoma(37;0.183)	OV - Ovarian serous cystadenocarcinoma(155;5.27e-11)														---	---	---	---
SYNE1	23345	broad.mit.edu	37	6	152642258	152642258	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:152642258delT	uc010kiw.2	-						SYNE1_uc010kiv.2_5'Flank|SYNE1_uc003qos.3_5'Flank|SYNE1_uc003qot.3_Intron|SYNE1_uc003qou.3_Intron|SYNE1_uc010kiz.2_Intron	NM_182961	NP_892006			spectrin repeat containing, nuclear envelope 1						cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)											HNSCC(10;0.0054)			---	---	---	---
TFB1M	51106	broad.mit.edu	37	6	155632541	155632541	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:155632541delA	uc003qqj.3	-						TFB1M_uc003qqk.2_Intron	NM_016020	NP_057104			transcription factor B1, mitochondrial						regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial nucleoid	DNA binding|protein binding|rRNA (adenine-N6,N6-)-dimethyltransferase activity			skin(1)	1		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;1.48e-12)|BRCA - Breast invasive adenocarcinoma(81;0.0131)														---	---	---	---
RSPH3	83861	broad.mit.edu	37	6	159399331	159399331	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:159399331delT	uc003qrx.2	-	7	1523	c.1333delA	c.(1333-1335)ACCfs	p.T445fs	RSPH3_uc010kju.2_Frame_Shift_Del_p.T349fs	NM_031924	NP_114130	Q86UC2	RSPH3_HUMAN	radial spoke 3 homolog	445										ovary(1)|skin(1)	2		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;2.36e-16)|BRCA - Breast invasive adenocarcinoma(81;5.92e-06)														---	---	---	---
MAP3K4	4216	broad.mit.edu	37	6	161469523	161469523	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:161469523delT	uc003qtn.2	+						MAP3K4_uc010kkc.1_Intron|MAP3K4_uc003qto.2_Intron|MAP3K4_uc011efz.1_Intron|MAP3K4_uc011ega.1_Intron	NM_005922	NP_005913			mitogen-activated protein kinase kinase kinase 4						activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			ovary(3)|lung(3)|skin(2)|stomach(1)	9		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)														---	---	---	---
RPS6KA2	6196	broad.mit.edu	37	6	167184290	167184290	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:167184290delA	uc003qvd.1	-						RPS6KA2_uc003qvc.1_Intron	NM_021135	NP_066958			ribosomal protein S6 kinase, 90kDa, polypeptide						axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|skin(2)|large_intestine(1)|central_nervous_system(1)	8		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)														---	---	---	---
CCR6	1235	broad.mit.edu	37	6	167417716	167417716	+	5'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:167417716delT	uc003qvl.2	+	3					FGFR1OP_uc011egp.1_Intron|FGFR1OP_uc003qvj.2_Intron|FGFR1OP_uc003qvk.2_Intron	NM_031409	NP_113597			chemokine (C-C motif) receptor 6						cellular defense response|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|humoral immune response	integral to plasma membrane	C-C chemokine receptor activity			ovary(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;8.21e-20)|BRCA - Breast invasive adenocarcinoma(81;4.55e-06)|GBM - Glioblastoma multiforme(31;0.00507)														---	---	---	---
FGFR1OP	11116	broad.mit.edu	37	6	167446008	167446008	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:167446008delT	uc003qvj.2	+						CCR6_uc003qvl.2_Intron|FGFR1OP_uc011egp.1_Intron|FGFR1OP_uc003qvk.2_Intron	NM_007045	NP_008976			FGFR1 oncogene partner isoform a						G2/M transition of mitotic cell cycle|microtubule anchoring|positive regulation of cell growth|positive regulation of cell migration|positive regulation of cell proliferation	centrosome|cytosol|nucleus|perinuclear region of cytoplasm	protein homodimerization activity|protein kinase binding|protein tyrosine kinase inhibitor activity			ovary(1)	1		Breast(66;1.48e-05)|Ovarian(120;0.0607)		OV - Ovarian serous cystadenocarcinoma(33;1.73e-19)|BRCA - Breast invasive adenocarcinoma(81;5.1e-06)|GBM - Glioblastoma multiforme(31;0.00231)				T	FGFR1	MPD|NHL								---	---	---	---
UNC93A	54346	broad.mit.edu	37	6	167719047	167719047	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:167719047delT	uc003qvq.2	+						UNC93A_uc003qvr.2_Intron	NM_018974	NP_061847			unc-93 homolog A isoform 1							integral to membrane|plasma membrane					0		Breast(66;7.62e-05)|Ovarian(120;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)														---	---	---	---
SMOC2	64094	broad.mit.edu	37	6	168949946	168949946	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:168949946delT	uc003qws.1	+						SMOC2_uc003qwr.1_Intron	NM_022138	NP_071421			SPARC related modular calcium binding 2						signal transduction	basement membrane	calcium ion binding			ovary(1)	1		Breast(66;0.000141)|Esophageal squamous(34;0.222)|Ovarian(120;0.231)		OV - Ovarian serous cystadenocarcinoma(33;1.31e-19)|BRCA - Breast invasive adenocarcinoma(81;3.06e-06)|GBM - Glioblastoma multiforme(31;0.00109)														---	---	---	---
C7orf50	84310	broad.mit.edu	37	7	1049694	1049694	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:1049694delT	uc003sju.2	-	3	285	c.215delA	c.(214-216)AAGfs	p.K72fs	C7orf50_uc003sjs.2_RNA|C7orf50_uc011jvt.1_Frame_Shift_Del_p.K72fs|C7orf50_uc011jvu.1_Frame_Shift_Del_p.K72fs	NM_032350	NP_115726	Q9BRJ6	CG050_HUMAN	hypothetical protein LOC84310	72							protein binding				0		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0216)|OV - Ovarian serous cystadenocarcinoma(56;1.3e-15)														---	---	---	---
C7orf50	84310	broad.mit.edu	37	7	1167118	1167120	+	Intron	DEL	AAA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:1167118_1167120delAAA	uc003sju.2	-						C7orf50_uc011jvt.1_Intron|C7orf50_uc011jvu.1_Intron	NM_032350	NP_115726			hypothetical protein LOC84310								protein binding				0		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0216)|OV - Ovarian serous cystadenocarcinoma(56;1.3e-15)														---	---	---	---
MICALL2	79778	broad.mit.edu	37	7	1488150	1488150	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:1488150delG	uc003skj.3	-							NM_182924	NP_891554			MICAL-like 2 isoform 1							cytoplasm|cytoskeleton	zinc ion binding			central_nervous_system(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;6.01e-15)														---	---	---	---
SNX8	29886	broad.mit.edu	37	7	2317696	2317696	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:2317696delC	uc003slw.2	-							NM_013321	NP_037453			sorting nexin 8						cell communication|early endosome to Golgi transport|intracellular protein transport	early endosome membrane	phosphatidylinositol binding|protein binding			large_intestine(1)|ovary(1)	2		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0853)|OV - Ovarian serous cystadenocarcinoma(56;3.79e-14)														---	---	---	---
EIF3B	8662	broad.mit.edu	37	7	2413963	2413963	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:2413963delT	uc003slx.2	+						EIF3B_uc003sly.2_Intron|EIF3B_uc003sma.2_Intron|EIF3B_uc003smb.2_5'Flank	NM_003751	NP_003742			eukaryotic translation initiation factor 3,						regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity				0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)														---	---	---	---
FOXK1	221937	broad.mit.edu	37	7	4796967	4796967	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:4796967delA	uc003snc.1	+						FOXK1_uc003sna.1_Intron	NM_001037165	NP_001032242			forkhead box K1						cell differentiation|embryo development|muscle organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			upper_aerodigestive_tract(1)|skin(1)	2		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;7.43e-15)														---	---	---	---
TNRC18	84629	broad.mit.edu	37	7	5391519	5391519	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:5391519delA	uc003soi.3	-	17	5750	c.5401delT	c.(5401-5403)TGTfs	p.C1801fs	TNRC18_uc003soj.2_Frame_Shift_Del_p.C183fs	NM_001080495	NP_001073964	O15417	TNC18_HUMAN	trinucleotide repeat containing 18	1801							DNA binding				0		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)														---	---	---	---
C7orf28A	51622	broad.mit.edu	37	7	5959840	5959841	+	Intron	INS	-	T	T	rs66913770		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:5959840_5959841insT	uc003spf.2	+							NM_015622	NP_056437			hypothetical protein LOC51622							lysosomal membrane					0		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0974)|OV - Ovarian serous cystadenocarcinoma(56;7.91e-15)														---	---	---	---
USP42	84132	broad.mit.edu	37	7	6187259	6187259	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:6187259delT	uc011jwo.1	+						USP42_uc010kth.1_Intron|USP42_uc011jwp.1_Intron|USP42_uc011jwq.1_Intron|USP42_uc011jwr.1_Intron	NM_032172	NP_115548			ubiquitin specific peptidase 42						cell differentiation|protein deubiquitination|spermatogenesis|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			skin(2)|ovary(1)|pancreas(1)|breast(1)	5		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.108)|OV - Ovarian serous cystadenocarcinoma(56;5.77e-14)														---	---	---	---
PMS2CL	441194	broad.mit.edu	37	7	6775133	6775133	+	Intron	DEL	T	-	-	rs138405905		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:6775133delT	uc011jxb.1	+						PMS2CL_uc003squ.2_Intron|PMS2CL_uc003sqv.1_Intron					SubName: Full=cDNA FLJ60281, highly similar to PMS1 protein homolog 2;												0																		---	---	---	---
MIOS	54468	broad.mit.edu	37	7	7625047	7625048	+	Intron	DEL	CT	-	-	rs66677224	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:7625047_7625048delCT	uc003srf.2	+						MIOS_uc003srg.2_Intron|MIOS_uc010ktq.2_5'Flank	NM_019005	NP_061878			missing oocyte, meiosis regulator, homolog												0																		---	---	---	---
THSD7A	221981	broad.mit.edu	37	7	11452108	11452108	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:11452108delA	uc003ssf.3	-							NM_015204	NP_056019			thrombospondin, type I, domain containing 7A							integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)											HNSCC(18;0.044)			---	---	---	---
MACC1	346389	broad.mit.edu	37	7	20180359	20180360	+	3'UTR	INS	-	A	A	rs138359838	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:20180359_20180360insA	uc003sus.3	-	7					MACC1_uc010kug.2_3'UTR	NM_182762	NP_877439			putative binding protein 7a5						positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			ovary(2)|skin(1)	3																		---	---	---	---
RAPGEF5	9771	broad.mit.edu	37	7	22330863	22330865	+	Intron	DEL	AAA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:22330863_22330865delAAA	uc003svg.2	-							NM_012294	NP_036426			Rap guanine nucleotide exchange factor (GEF) 5						nervous system development|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	nucleus	GTP-dependent protein binding|Rap guanyl-nucleotide exchange factor activity			ovary(1)	1																		---	---	---	---
STK31	56164	broad.mit.edu	37	7	23768536	23768537	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:23768536_23768537insT	uc003sws.3	+						STK31_uc003swt.3_Intron|STK31_uc011jze.1_Intron|STK31_uc010kuq.2_Intron	NM_031414	NP_113602			serine/threonine kinase 31 isoform a								ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9																		---	---	---	---
GARS	2617	broad.mit.edu	37	7	30662267	30662267	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:30662267delT	uc003tbm.2	+							NM_002047	NP_002038			glycyl-tRNA synthetase						cell death|diadenosine tetraphosphate biosynthetic process|glycyl-tRNA aminoacylation	cytosol|mitochondrial matrix|soluble fraction	ATP binding|glycine-tRNA ligase activity|protein dimerization activity			ovary(1)	1					Glycine(DB00145)													---	---	---	---
CRHR2	1395	broad.mit.edu	37	7	30694783	30694783	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:30694783delG	uc003tbn.2	-						CRHR2_uc010kvw.1_Intron|CRHR2_uc010kvx.1_Intron|CRHR2_uc010kvy.1_Intron|CRHR2_uc003tbo.2_Intron|CRHR2_uc003tbp.2_Intron	NM_001883	NP_001874			corticotropin releasing hormone receptor 2						G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			lung(2)|ovary(1)|skin(1)	4																		---	---	---	---
AVL9	23080	broad.mit.edu	37	7	32867251	32867251	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:32867251delT	uc011kai.1	+						uc003tda.1_Intron	NM_015060	NP_055875			AVL9 homolog (S. cerevisiase)							integral to membrane					0																		---	---	---	---
BMPER	168667	broad.mit.edu	37	7	34118338	34118338	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:34118338delT	uc011kap.1	+							NM_133468	NP_597725			BMP-binding endothelial regulator precursor						blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3																		---	---	---	---
SEPT7	989	broad.mit.edu	37	7	35944037	35944038	+	3'UTR	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:35944037_35944038delTT	uc010kxc.2	+	13					SEPT7_uc011kat.1_3'UTR|SEPT7_uc011kau.1_3'UTR|SEPT7_uc011kav.1_3'UTR|SEPT7_uc003tey.2_3'UTR	NM_001788	NP_001779			cell division cycle 10 isoform 1						cilium morphogenesis|cytokinesis|mitosis|protein heterooligomerization|regulation of embryonic cell shape	cilium axoneme|cleavage furrow|condensed chromosome kinetochore|midbody|nucleus|septin complex|spindle|stress fiber	GTP binding|protein binding|structural molecule activity				0																		---	---	---	---
ANLN	54443	broad.mit.edu	37	7	36466799	36466802	+	Intron	DEL	TTTT	-	-	rs66486276		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:36466799_36466802delTTTT	uc003tff.2	+						ANLN_uc011kaz.1_Intron|ANLN_uc003tfg.2_Intron|ANLN_uc010kxe.2_Intron	NM_018685	NP_061155			anillin, actin binding protein						cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			ovary(2)|skin(1)	3																		---	---	---	---
POU6F2	11281	broad.mit.edu	37	7	39246850	39246850	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:39246850delT	uc003thb.1	+						POU6F2_uc010kxo.2_Intron	NM_007252	NP_009183			POU class 6 homeobox 2 isoform 1						central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1																		---	---	---	---
GLI3	2737	broad.mit.edu	37	7	42006987	42006987	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:42006987delT	uc011kbh.1	-						GLI3_uc011kbg.1_Intron	NM_000168	NP_000159			GLI-Kruppel family member GLI3						negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19														Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				---	---	---	---
SPDYE1	285955	broad.mit.edu	37	7	44043625	44043625	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:44043625delT	uc003tjf.2	+						POLR2J4_uc003tjc.2_Intron|POLR2J4_uc003tjd.2_Intron|POLR2J4_uc010kxw.2_Intron|POLR2J4_uc003tje.3_Intron	NM_175064	NP_778234			Williams Beuren syndrome chromosome region 19											ovary(1)	1																		---	---	---	---
SUN3	256979	broad.mit.edu	37	7	48047096	48047096	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:48047096delA	uc003tof.2	-						SUN3_uc010kyq.2_Intron|SUN3_uc003tog.2_Intron|SUN3_uc011kcf.1_Intron	NM_152782	NP_689995			Sad1 and UNC84 domain containing 1							integral to membrane				central_nervous_system(1)	1																		---	---	---	---
ABCA13	154664	broad.mit.edu	37	7	48266654	48266654	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:48266654delA	uc003toq.2	+						ABCA13_uc003top.2_Intron|ABCA13_uc010kyr.2_Intron	NM_152701	NP_689914			ATP binding cassette, sub-family A (ABC1),						transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10																		---	---	---	---
ABCA13	154664	broad.mit.edu	37	7	48308448	48308454	+	Intron	DEL	TTTTTTT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:48308448_48308454delTTTTTTT	uc003toq.2	+						ABCA13_uc010kyr.2_Intron	NM_152701	NP_689914			ATP binding cassette, sub-family A (ABC1),						transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10																		---	---	---	---
GRB10	2887	broad.mit.edu	37	7	50683852	50683852	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:50683852delG	uc003tpi.2	-						GRB10_uc003tph.3_Intron|GRB10_uc003tpj.2_Intron|GRB10_uc003tpk.2_Intron|GRB10_uc010kzb.2_Intron|GRB10_uc003tpl.2_Intron|GRB10_uc003tpm.2_Intron|GRB10_uc003tpn.2_Intron	NM_005311	NP_005302			growth factor receptor-bound protein 10 isoform						insulin receptor signaling pathway|insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway	cytosol|plasma membrane	insulin receptor binding|insulin receptor binding|SH3/SH2 adaptor activity			lung(3)|ovary(2)|upper_aerodigestive_tract(1)	6	Glioma(55;0.08)|all_neural(89;0.245)													Russell-Silver_syndrome				---	---	---	---
Unknown	0	broad.mit.edu	37	7	65083820	65083821	+	IGR	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:65083820_65083821insT								ZNF92 (217823 upstream) : INTS4L2 (28956 downstream)																																			---	---	---	---
ASL	435	broad.mit.edu	37	7	65554524	65554525	+	Intron	INS	-	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:65554524_65554525insG	uc003tuo.2	+						ASL_uc003tup.2_Intron|ASL_uc003tur.2_Intron|ASL_uc003tuq.2_Intron	NM_000048	NP_000039			argininosuccinate lyase isoform 1						arginine biosynthetic process via ornithine|arginine catabolic process|urea cycle	cytosol	argininosuccinate lyase activity			breast(2)	2					L-Arginine(DB00125)													---	---	---	---
Unknown	0	broad.mit.edu	37	7	66321905	66321908	+	IGR	DEL	TTTT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:66321905_66321908delTTTT								LOC729156 (12092 upstream) : C7orf42 (64295 downstream)																																			---	---	---	---
TYW1B	441250	broad.mit.edu	37	7	72286071	72286071	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:72286071delA	uc011kej.1	-						TYW1B_uc011keh.1_Intron|TYW1B_uc011kek.1_Intron	NM_001145440	NP_001138912			tRNA-yW synthesizing protein 1 homolog B isoform						tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity				0																		---	---	---	---
NSUN5	55695	broad.mit.edu	37	7	72718102	72718104	+	Intron	DEL	GAG	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:72718102_72718104delGAG	uc003txw.2	-						FKBP6_uc003twz.2_Intron|NSUN5_uc003txv.2_Intron|NSUN5_uc003txx.2_Intron|NSUN5_uc011kev.1_Intron	NM_018044	NP_060514			NOL1/NOP2/Sun domain family, member 5 isoform 2								methyltransferase activity				0		Lung NSC(55;0.163)																---	---	---	---
TRIM50	135892	broad.mit.edu	37	7	72729267	72729267	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:72729267delA	uc010lbd.1	-						FKBP6_uc003twz.2_Intron|TRIM50_uc003txy.1_Intron|TRIM50_uc003txz.1_Intron	NM_178125	NP_835226			tripartite motif protein 50A							cytoplasm|intracellular membrane-bounded organelle	ligase activity|zinc ion binding			skin(1)	1																		---	---	---	---
EIF4H	7458	broad.mit.edu	37	7	73601779	73601779	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:73601779delT	uc003uad.1	+						RFC2_uc011kfa.1_Intron|EIF4H_uc011kfg.1_Intron|EIF4H_uc010lbm.2_Intron|EIF4H_uc003uae.1_Intron|EIF4H_uc003uaf.1_Intron	NM_022170	NP_071496			eukaryotic translation initiation factor 4H						interspecies interaction between organisms|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex|perinuclear region of cytoplasm	nucleotide binding|protein binding|translation initiation factor activity				0																		---	---	---	---
GTF2I	2969	broad.mit.edu	37	7	74105135	74105135	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:74105135delT	uc003uau.2	+						GTF2I_uc003uat.2_Intron|GTF2I_uc003uav.2_Intron|GTF2I_uc003uaw.2_Intron|GTF2I_uc003uay.2_Intron|GTF2I_uc003uax.2_Intron	NM_032999	NP_127492			general transcription factor IIi isoform 1						negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0																		---	---	---	---
GTF2I	2969	broad.mit.edu	37	7	74129370	74129371	+	Intron	INS	-	T	T	rs140756201	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:74129370_74129371insT	uc003uau.2	+						GTF2I_uc003uat.2_Intron|GTF2I_uc003uav.2_Intron|GTF2I_uc003uaw.2_Intron|GTF2I_uc003uay.2_Intron|GTF2I_uc003uax.2_Intron|uc003uaz.2_Intron	NM_032999	NP_127492			general transcription factor IIi isoform 1						negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0																		---	---	---	---
GTF2I	2969	broad.mit.edu	37	7	74160435	74160436	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:74160435_74160436insT	uc003uau.2	+						GTF2I_uc003uav.2_Intron|GTF2I_uc003uaw.2_Intron|GTF2I_uc003uay.2_Intron|GTF2I_uc003uax.2_Intron|GTF2I_uc003uba.2_5'Flank	NM_032999	NP_127492			general transcription factor IIi isoform 1						negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0																		---	---	---	---
GTF2I	2969	broad.mit.edu	37	7	74160446	74160447	+	Intron	DEL	TA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:74160446_74160447delTA	uc003uau.2	+						GTF2I_uc003uav.2_Intron|GTF2I_uc003uaw.2_Intron|GTF2I_uc003uay.2_Intron|GTF2I_uc003uax.2_Intron|GTF2I_uc003uba.2_5'Flank	NM_032999	NP_127492			general transcription factor IIi isoform 1						negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0																		---	---	---	---
GTF2I	2969	broad.mit.edu	37	7	74160628	74160629	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:74160628_74160629insT	uc003uau.2	+						GTF2I_uc003uav.2_Intron|GTF2I_uc003uaw.2_Intron|GTF2I_uc003uay.2_Intron|GTF2I_uc003uax.2_Intron|GTF2I_uc003uba.2_5'Flank	NM_032999	NP_127492			general transcription factor IIi isoform 1						negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0																		---	---	---	---
GTF2I	2969	broad.mit.edu	37	7	74172387	74172388	+	Intron	INS	-	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:74172387_74172388insC	uc003uau.2	+						GTF2I_uc003uav.2_Intron|GTF2I_uc003uaw.2_Intron|GTF2I_uc003uay.2_Intron|GTF2I_uc003uax.2_Intron|GTF2I_uc003uba.2_Intron	NM_032999	NP_127492			general transcription factor IIi isoform 1						negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0																		---	---	---	---
PION	54103	broad.mit.edu	37	7	76985105	76985111	+	Intron	DEL	TTTTTTT	-	-	rs148300900		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:76985105_76985111delTTTTTTT	uc003ugf.2	-						PION_uc003ugg.1_Intron	NM_017439	NP_059135			pigeon homolog						beta-amyloid formation|regulation of proteolysis	trans-Golgi network	beta-amyloid binding			central_nervous_system(1)	1																		---	---	---	---
MAGI2	9863	broad.mit.edu	37	7	77807188	77807188	+	Intron	DEL	A	-	-	rs113984102		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:77807188delA	uc003ugx.2	-						MAGI2_uc003ugy.2_Intron|MAGI2_uc010ldx.1_Intron	NM_012301	NP_036433			membrane associated guanylate kinase, WW and PDZ							cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)																---	---	---	---
DBF4	10926	broad.mit.edu	37	7	87525778	87525778	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:87525778delT	uc003ujf.1	+						DBF4_uc003ujh.1_Intron|DBF4_uc003ujg.1_Intron|DBF4_uc011khf.1_Intron	NM_006716	NP_006707			activator of S phase kinase						cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	enzyme activator activity|nucleic acid binding|protein binding|zinc ion binding			lung(2)	2	Esophageal squamous(14;0.00202)	Breast(660;0.0334)																---	---	---	---
CCDC132	55610	broad.mit.edu	37	7	92883251	92883251	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:92883251delA	uc003umo.2	+						CCDC132_uc003umq.2_Intron|CCDC132_uc003ump.2_Intron|CCDC132_uc003umr.2_Intron|CCDC132_uc011khz.1_Intron|CCDC132_uc003umn.2_Intron	NM_017667	NP_060137			coiled-coil domain containing 132 isoform a												0	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)															---	---	---	---
SHFM1	7979	broad.mit.edu	37	7	96318421	96318422	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:96318421_96318422insA	uc003uoi.2	-						SHFM1_uc010lfn.1_Intron	NM_006304	NP_006295			split hand/foot malformation type 1						proteolysis	proteasome complex	peptidase activity|protein binding				0	all_cancers(62;4.24e-09)|all_epithelial(64;5.59e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0353)|Lung NSC(181;0.0987)												Direct_reversal_of_damage|Homologous_recombination					---	---	---	---
ASNS	440	broad.mit.edu	37	7	97493436	97493437	+	Intron	INS	-	A	A	rs2302088	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:97493436_97493437insA	uc003uot.3	-						ASNS_uc011kin.1_Intron|ASNS_uc003uou.3_Intron|ASNS_uc003uov.3_Intron|ASNS_uc011kio.1_Intron|ASNS_uc003uow.3_Intron|ASNS_uc003uox.3_Intron	NM_133436	NP_597680			asparagine synthetase						cellular response to glucose starvation|glutamine metabolic process|negative regulation of apoptosis|positive regulation of mitotic cell cycle	cytosol|soluble fraction	asparagine synthase (glutamine-hydrolyzing) activity|ATP binding			ovary(1)	1	all_cancers(62;6.64e-09)|all_epithelial(64;1.58e-09)|Esophageal squamous(72;0.00448)|Lung NSC(181;0.0342)|all_lung(186;0.0369)				Adenosine triphosphate(DB00171)|L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)													---	---	---	---
ARPC1B	10095	broad.mit.edu	37	7	98985652	98985652	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:98985652delC	uc003upz.2	+						ARPC1A_uc011kit.1_Intron|ARPC1B_uc003uqa.2_Intron|ARPC1B_uc003uqb.2_Intron|ARPC1B_uc003uqc.2_Intron|ARPC1B_uc003uqd.2_5'Flank	NM_005720	NP_005711			actin related protein 2/3 complex subunit 1B						cellular component movement|regulation of actin filament polymerization	Arp2/3 protein complex|cytoplasm	actin binding|structural constituent of cytoskeleton				0	all_cancers(62;3.49e-09)|all_epithelial(64;2.57e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)															---	---	---	---
ZKSCAN5	23660	broad.mit.edu	37	7	99118040	99118040	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99118040delT	uc003uqv.2	+						ZKSCAN5_uc010lfx.2_Intron|ZKSCAN5_uc003uqw.2_Intron|ZKSCAN5_uc003uqx.2_Intron|ZKSCAN5_uc003uqy.2_Intron	NM_145102	NP_659570			zinc finger with KRAB and SCAN domains 5						viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)																	---	---	---	---
Unknown	0	broad.mit.edu	37	7	99581179	99581179	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99581179delC	uc003usi.2	+											RecName: Full=Putative zinc-alpha-2-glycoprotein-like 2; Flags: Precursor;																														---	---	---	---
ZSCAN21	7589	broad.mit.edu	37	7	99661218	99661218	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99661218delA	uc003uso.2	+						ZSCAN21_uc003usn.1_Intron	NM_145914	NP_666019			zinc finger protein 38						positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)															---	---	---	---
GIGYF1	64599	broad.mit.edu	37	7	100279327	100279327	+	3'UTR	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100279327delG	uc003uwg.1	-	24						NM_022574	NP_072096			PERQ amino acid rich, with GYF domain 1											large_intestine(1)|central_nervous_system(1)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)																	---	---	---	---
PMPCB	9512	broad.mit.edu	37	7	102940906	102940906	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:102940906delT	uc003vbl.2	+						PMPCB_uc010liu.1_Intron|PMPCB_uc003vbk.1_Intron|PMPCB_uc003vbm.2_Intron|PMPCB_uc010liv.2_Intron|PMPCB_uc010liw.2_Intron|PMPCB_uc011kll.1_Intron|PMPCB_uc011klm.1_Intron	NM_004279	NP_004270			mitochondrial processing peptidase beta subunit						proteolysis	mitochondrial matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)	4																		---	---	---	---
DNAJC2	27000	broad.mit.edu	37	7	102978263	102978263	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:102978263delA	uc003vbo.2	-						DNAJC2_uc003vbn.2_Intron|DNAJC2_uc010lix.2_Intron|DNAJC2_uc003vbp.2_Intron|DNAJC2_uc003vbq.1_Intron|DNAJC2_uc003vbr.1_Intron	NM_014377	NP_055192			DnaJ (Hsp40) homolog, subfamily C, member 2						'de novo' cotranslational protein folding|chromatin modification|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nuclear membrane	chromatin binding|DNA binding|histone binding|Hsp70 protein binding|ubiquitin binding			kidney(1)	1																		---	---	---	---
PUS7	54517	broad.mit.edu	37	7	105102889	105102889	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:105102889delA	uc003vcx.2	-						PUS7_uc010lji.2_Intron|PUS7_uc003vcy.2_Intron|PUS7_uc003vcz.1_Intron	NM_019042	NP_061915			pseudouridylate synthase 7 homolog						pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)	1																		---	---	---	---
NAMPT	10135	broad.mit.edu	37	7	105908966	105908966	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:105908966delT	uc003vdq.2	-	6	995	c.687delA	c.(685-687)AAAfs	p.K229fs	NAMPT_uc003vdr.1_Frame_Shift_Del_p.K229fs|NAMPT_uc011klu.1_Frame_Shift_Del_p.K142fs	NM_005746	NP_005737	P43490	NAMPT_HUMAN	nicotinamide phosphoribosyltransferase	229					cell-cell signaling|NAD biosynthetic process|nicotinamide metabolic process|positive regulation of cell proliferation|positive regulation of nitric-oxide synthase biosynthetic process|signal transduction|water-soluble vitamin metabolic process	cytosol	cytokine activity|nicotinamide phosphoribosyltransferase activity|nicotinate phosphoribosyltransferase activity|nicotinate-nucleotide diphosphorylase (carboxylating) activity			large_intestine(1)	1																		---	---	---	---
NAMPT	10135	broad.mit.edu	37	7	105917290	105917290	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:105917290delA	uc003vdq.2	-						NAMPT_uc003vdr.1_Intron|NAMPT_uc011klu.1_Intron	NM_005746	NP_005737			nicotinamide phosphoribosyltransferase						cell-cell signaling|NAD biosynthetic process|nicotinamide metabolic process|positive regulation of cell proliferation|positive regulation of nitric-oxide synthase biosynthetic process|signal transduction|water-soluble vitamin metabolic process	cytosol	cytokine activity|nicotinamide phosphoribosyltransferase activity|nicotinate phosphoribosyltransferase activity|nicotinate-nucleotide diphosphorylase (carboxylating) activity			large_intestine(1)	1																		---	---	---	---
LAMB4	22798	broad.mit.edu	37	7	107698419	107698419	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:107698419delA	uc010ljo.1	-						LAMB4_uc003vey.2_Intron|LAMB4_uc010ljp.1_Intron	NM_007356	NP_031382			laminin, beta 4 precursor						cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8																		---	---	---	---
LAMB4	22798	broad.mit.edu	37	7	107745286	107745286	+	Intron	DEL	T	-	-	rs138912987		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:107745286delT	uc010ljo.1	-						LAMB4_uc003vey.2_Intron	NM_007356	NP_031382			laminin, beta 4 precursor						cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8																		---	---	---	---
LAMB4	22798	broad.mit.edu	37	7	107749452	107749452	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:107749452delT	uc010ljo.1	-						LAMB4_uc003vey.2_Intron	NM_007356	NP_031382			laminin, beta 4 precursor						cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8																		---	---	---	---
ASZ1	136991	broad.mit.edu	37	7	117003505	117003505	+	3'UTR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:117003505delA	uc003vjb.2	-	13					ASZ1_uc011kno.1_3'UTR|ASZ1_uc011knp.1_3'UTR	NM_130768	NP_570124			ankyrin repeat, SAM and basic leucine zipper						cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(10;0.00156)|all_lung(10;0.00175)		STAD - Stomach adenocarcinoma(10;0.000512)															---	---	---	---
CTTNBP2	83992	broad.mit.edu	37	7	117431024	117431024	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:117431024delA	uc003vjf.2	-							NM_033427	NP_219499			cortactin binding protein 2											ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)														---	---	---	---
Unknown	0	broad.mit.edu	37	7	121081380	121081380	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:121081380delT								FAM3C (44958 upstream) : PTPRZ1 (431779 downstream)																																			---	---	---	---
PTPRZ1	5803	broad.mit.edu	37	7	121636765	121636765	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:121636765delA	uc003vjy.2	+						PTPRZ1_uc003vjz.2_Intron	NM_002851	NP_002842			protein tyrosine phosphatase, receptor-type,						central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9																		---	---	---	---
AASS	10157	broad.mit.edu	37	7	121753991	121753992	+	Intron	INS	-	G	G	rs141362875	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:121753991_121753992insG	uc003vka.2	-						AASS_uc011knu.1_Intron|AASS_uc011knv.1_Intron|AASS_uc003vkb.2_Intron|AASS_uc011knw.1_Intron	NM_005763	NP_005754			aminoadipate-semialdehyde synthase precursor						protein tetramerization	mitochondrial matrix	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity			upper_aerodigestive_tract(1)|ovary(1)	2					L-Glutamic Acid(DB00142)|NADH(DB00157)													---	---	---	---
CADPS2	93664	broad.mit.edu	37	7	122269208	122269208	+	Intron	DEL	T	-	-	rs78099125		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:122269208delT	uc010lkp.2	-						CADPS2_uc010lkq.2_Intron	NM_017954	NP_060424			Ca2+-dependent activator protein for secretion 2						exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
IQUB	154865	broad.mit.edu	37	7	123152550	123152550	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:123152550delA	uc003vkn.2	-						IQUB_uc003vko.2_Intron|IQUB_uc010lkt.2_Intron|IQUB_uc003vkp.1_Intron|IQUB_uc003vkq.2_Intron	NM_178827	NP_849149			IQ motif and ubiquitin domain containing											ovary(3)|large_intestine(1)	4																		---	---	---	---
RBM28	55131	broad.mit.edu	37	7	127979090	127979090	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:127979090delA	uc003vmp.2	-						RBM28_uc011koj.1_Intron|RBM28_uc011kok.1_Intron	NM_018077	NP_060547			RNA binding motif protein 28						mRNA processing|RNA splicing	Golgi apparatus|nucleolus|spliceosomal complex	nucleotide binding|RNA binding			ovary(2)	2																		---	---	---	---
TNPO3	23534	broad.mit.edu	37	7	128630316	128630316	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:128630316delA	uc003vol.1	-						TNPO3_uc003vom.1_Intron|TNPO3_uc010lly.1_Intron|TNPO3_uc010llz.1_Intron	NM_012470	NP_036602			transportin 3						splicing factor protein import into nucleus	cytoplasm|nucleus	protein binding|receptor activity			ovary(2)|skin(2)|lung(1)	5																		---	---	---	---
UBE2H	7328	broad.mit.edu	37	7	129497297	129497297	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:129497297delT	uc003vpf.1	-						UBE2H_uc003vpg.1_Intron	NM_003344	NP_003335			ubiquitin-conjugating enzyme E2H isoform 1						protein K11-linked ubiquitination|protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process		ATP binding|ubiquitin-protein ligase activity			skin(1)	1	Melanoma(18;0.0435)																	---	---	---	---
MEST	4232	broad.mit.edu	37	7	130142761	130142761	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:130142761delA	uc003vqg.2	+						MEST_uc003vqc.2_Intron|MEST_uc003vqd.2_Intron|MEST_uc003vqf.2_Intron|MEST_uc011kph.1_Intron|MEST_uc010lmg.2_Intron	NM_002402	NP_002393			mesoderm specific transcript isoform a						mesoderm development	endoplasmic reticulum membrane|integral to membrane	hydrolase activity|protein binding			ovary(2)	2	Melanoma(18;0.0435)																	---	---	---	---
COPG2	26958	broad.mit.edu	37	7	130289682	130289682	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:130289682delT	uc003vqh.1	-							NM_012133	NP_036265			coatomer protein complex, subunit gamma 2						intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat	protein binding|structural molecule activity				0	Melanoma(18;0.0435)																	---	---	---	---
Unknown	0	broad.mit.edu	37	7	130507893	130507894	+	IGR	INS	-	T	T	rs75086098	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:130507893_130507894insT								KLF14 (89033 upstream) : MIR29A (53612 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	7	131438392	131438394	+	IGR	DEL	TTT	-	-	rs144638874		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:131438392_131438394delTTT								PODXL (197016 upstream) : PLXNA4 (369698 downstream)																																			---	---	---	---
CHCHD3	54927	broad.mit.edu	37	7	132470338	132470338	+	3'UTR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:132470338delA	uc003vre.2	-	8					CHCHD3_uc010lmi.2_RNA|CHCHD3_uc003vrf.2_3'UTR|CHCHD3_uc010lmj.2_Frame_Shift_Del_p.F111fs	NM_017812	NP_060282			coiled-coil-helix-coiled-coil-helix domain						inner mitochondrial membrane organization|mitochondrial fusion	mitochondrial inner membrane	protein complex scaffold				0																		---	---	---	---
WDR91	29062	broad.mit.edu	37	7	134874036	134874036	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:134874036delA	uc003vsp.2	-						WDR91_uc010lmq.2_Intron|WDR91_uc010lmr.2_Intron	NM_014149	NP_054868			WD repeat domain 91											breast(2)|ovary(1)|skin(1)	4																		---	---	---	---
DGKI	9162	broad.mit.edu	37	7	137092353	137092353	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:137092353delA	uc003vtt.2	-						DGKI_uc003vtu.2_Intron	NM_004717	NP_004708			diacylglycerol kinase, iota						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3																		---	---	---	---
DGKI	9162	broad.mit.edu	37	7	137339354	137339354	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:137339354delA	uc003vtt.2	-						DGKI_uc003vtu.2_Intron	NM_004717	NP_004708			diacylglycerol kinase, iota						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3																		---	---	---	---
TRIM24	8805	broad.mit.edu	37	7	138262411	138262411	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:138262411delT	uc003vuc.2	+						TRIM24_uc003vub.2_Intron	NM_015905	NP_056989			transcriptional intermediary factor 1 alpha						cellular response to estrogen stimulus|protein catabolic process|regulation of apoptosis|regulation of protein stability|transcription from RNA polymerase II promoter	cytoplasm	chromatin binding|estrogen response element binding|histone acetyl-lysine binding|p53 binding|transcription coactivator activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(3)|ovary(2)|stomach(1)|breast(1)|skin(1)	8																		---	---	---	---
ATP6V0A4	50617	broad.mit.edu	37	7	138406842	138406842	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:138406842delA	uc003vuf.2	-						ATP6V0A4_uc003vug.2_Intron|ATP6V0A4_uc003vuh.2_Intron	NM_130841	NP_570856			ATPase, H+ transporting, lysosomal V0 subunit						cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			pancreas(1)	1																		---	---	---	---
KIAA1549	57670	broad.mit.edu	37	7	138588599	138588604	+	Intron	DEL	GCGCGC	-	-	rs76062855		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:138588599_138588604delGCGCGC	uc011kql.1	-						KIAA1549_uc003vuk.3_Intron|KIAA1549_uc011kqj.1_Intron	NM_020910	NP_065961			hypothetical protein LOC57670 isoform 1							integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230								O	BRAF	pilocytic astrocytoma								---	---	---	---
UBN2	254048	broad.mit.edu	37	7	138969521	138969521	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:138969521delT	uc011kqr.1	+							NM_173569	NP_775840			ubinuclein 2											ovary(1)|skin(1)	2																		---	---	---	---
BRAF	673	broad.mit.edu	37	7	140476994	140476995	+	Intron	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:140476994_140476995delTT	uc003vwc.3	-							NM_004333	NP_004324			B-Raf						activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)		61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				---	---	---	---
FAM115C	285966	broad.mit.edu	37	7	143343624	143343624	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:143343624delA	uc003wdf.2	+						FAM115C_uc003wdg.2_Intron|FAM115C_uc011ktk.1_Intron|FAM115C_uc003wdh.2_Intron|FAM115C_uc011ktm.1_Intron|uc011ktn.1_Intron|uc011kto.1_Intron|uc011ktp.1_Intron|LOC154761_uc011ktq.1_Intron|LOC154761_uc011ktr.1_Intron|LOC154761_uc011kts.1_Intron	NM_001130025	NP_001123497			hypothetical protein LOC285966 isoform A												0																		---	---	---	---
FAM115C	285966	broad.mit.edu	37	7	143417881	143417881	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:143417881delT	uc003wdf.2	+						FAM115C_uc003wdg.2_Intron|FAM115C_uc011ktk.1_Intron|FAM115C_uc003wdh.2_Intron|FAM115C_uc011ktm.1_Intron|uc011ktn.1_Intron|uc011kto.1_Intron|uc011ktp.1_Intron|LOC154761_uc011ktq.1_Intron|LOC154761_uc011ktr.1_Intron|LOC154761_uc011kts.1_Intron|FAM115C_uc011ktt.1_Intron|FAM115C_uc003wdi.1_Intron	NM_001130025	NP_001123497			hypothetical protein LOC285966 isoform A												0																		---	---	---	---
OR2A9P	441295	broad.mit.edu	37	7	143975332	143975332	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:143975332delA	uc003wec.1	-						OR2A7_uc003wef.2_5'Flank					SubName: Full=Seven transmembrane helix receptor;												0																		---	---	---	---
Unknown	0	broad.mit.edu	37	7	148751396	148751396	+	IGR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:148751396delA								PDIA4 (25614 upstream) : ZNF786 (15337 downstream)																																			---	---	---	---
AGAP3	116988	broad.mit.edu	37	7	150813747	150813747	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:150813747delG	uc003wjg.1	+						AGAP3_uc003wje.1_Intron|AGAP3_uc003wjf.1_Intron|AGAP3_uc010lpy.1_Intron|AGAP3_uc003wjh.1_Intron	NM_031946	NP_114152			centaurin, gamma 3 isoform a						regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3																		---	---	---	---
MLL3	58508	broad.mit.edu	37	7	151876745	151876750	+	Intron	DEL	GGGGGG	-	-	rs72296975		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:151876745_151876750delGGGGGG	uc003wla.2	-						MLL3_uc003wkz.2_Intron|MLL3_uc003wky.2_5'Flank	NM_170606	NP_733751			myeloid/lymphoid or mixed-lineage leukemia 3						intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)				N		medulloblastoma								---	---	---	---
MLL3	58508	broad.mit.edu	37	7	151880259	151880259	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:151880259delA	uc003wla.2	-						MLL3_uc003wkz.2_Intron	NM_170606	NP_733751			myeloid/lymphoid or mixed-lineage leukemia 3						intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)				N		medulloblastoma								---	---	---	---
MLL3	58508	broad.mit.edu	37	7	151921130	151921132	+	In_Frame_Del	DEL	TCT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:151921130_151921132delTCT	uc003wla.2	-	20	3510_3512	c.3291_3293delAGA	c.(3289-3294)GAAGAT>GAT	p.E1097del	MLL3_uc003wkz.2_In_Frame_Del_p.E158del	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1097	PHD-type 6.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)				N		medulloblastoma								---	---	---	---
INSIG1	3638	broad.mit.edu	37	7	155095436	155095436	+	Intron	DEL	C	-	-	rs9768687	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:155095436delC	uc003wly.2	+						INSIG1_uc011kvu.1_Intron|INSIG1_uc003wlz.2_Intron	NM_005542	NP_005533			insulin induced gene 1 isoform 1						cell proliferation|ER-nuclear sterol response pathway	endoplasmic reticulum membrane|integral to membrane	protein binding				0	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)														---	---	---	---
LMBR1	64327	broad.mit.edu	37	7	156556614	156556615	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:156556614_156556615insA	uc003wmw.3	-						LMBR1_uc003wmv.3_Intron|LMBR1_uc003wmx.3_Intron|LMBR1_uc010lqn.2_Intron|LMBR1_uc011kvx.1_Intron	NM_022458	NP_071903			limb region 1 protein							integral to membrane	receptor activity				0	Ovarian(565;0.218)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.208)														---	---	---	---
PTPRN2	5799	broad.mit.edu	37	7	157449254	157449254	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:157449254delG	uc003wno.2	-						PTPRN2_uc003wnp.2_Intron|PTPRN2_uc003wnq.2_Intron|PTPRN2_uc003wnr.2_Intron|PTPRN2_uc011kwa.1_Intron	NM_002847	NP_002838			protein tyrosine phosphatase, receptor type, N							integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)														---	---	---	---
WDR60	55112	broad.mit.edu	37	7	158706914	158706914	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:158706914delT	uc003woe.3	+						WDR60_uc010lqv.2_Intron|WDR60_uc010lqw.2_Intron	NM_018051	NP_060521			WD repeat domain 60											ovary(2)|breast(1)|central_nervous_system(1)	4	Ovarian(565;0.152)	all_cancers(7;1.25e-09)|all_epithelial(9;0.000894)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)|STAD - Stomach adenocarcinoma(7;0.18)														---	---	---	---
CSMD1	64478	broad.mit.edu	37	8	2967875	2967875	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:2967875delA	uc011kwk.1	-						CSMD1_uc011kwj.1_Intron|CSMD1_uc010lrg.2_Intron	NM_033225	NP_150094			CUB and Sushi multiple domains 1 precursor							integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)														---	---	---	---
XKR5	389610	broad.mit.edu	37	8	6673270	6673271	+	Intron	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:6673270_6673271delAA	uc003wqp.2	-						XKR5_uc003wqq.2_Intron|XKR5_uc003wqr.1_Intron	NM_207411	NP_997294			XK-related protein 5a							integral to membrane					0			STAD - Stomach adenocarcinoma(24;0.0984)	READ - Rectum adenocarcinoma(644;0.137)|COAD - Colon adenocarcinoma(149;0.166)												OREG0018511	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
XKR5	389610	broad.mit.edu	37	8	6679301	6679302	+	Intron	DEL	CA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:6679301_6679302delCA	uc003wqp.2	-						XKR5_uc003wqq.2_Intron|XKR5_uc003wqr.1_Intron	NM_207411	NP_997294			XK-related protein 5a							integral to membrane					0			STAD - Stomach adenocarcinoma(24;0.0984)	READ - Rectum adenocarcinoma(644;0.137)|COAD - Colon adenocarcinoma(149;0.166)														---	---	---	---
SOX7	83595	broad.mit.edu	37	8	10583646	10583646	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:10583646delG	uc003wtf.2	-	2	848	c.769delC	c.(769-771)CTGfs	p.L257fs	SOX7_uc011kwz.1_Frame_Shift_Del_p.L309fs	NM_031439	NP_113627	Q9BT81	SOX7_HUMAN	SRY-box 7	257					endoderm formation|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of caspase activity|regulation of canonical Wnt receptor signaling pathway	cytoplasm|nucleus	transcription regulatory region DNA binding			breast(1)	1				COAD - Colon adenocarcinoma(149;0.0732)														---	---	---	---
LONRF1	91694	broad.mit.edu	37	8	12598161	12598161	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:12598161delA	uc003wwd.1	-						LONRF1_uc010lsp.1_Intron	NM_152271	NP_689484			LON peptidase N-terminal domain and ring finger						proteolysis		ATP-dependent peptidase activity|zinc ion binding			ovary(1)	1				READ - Rectum adenocarcinoma(644;0.236)														---	---	---	---
PCM1	5108	broad.mit.edu	37	8	17826953	17826953	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:17826953delT	uc003wyi.3	+						PCM1_uc011kyh.1_Intron|PCM1_uc003wyj.3_Intron|PCM1_uc011kyi.1_5'Flank|PCM1_uc011kyj.1_5'Flank|PCM1_uc003wyk.3_5'Flank	NM_006197	NP_006188			pericentriolar material 1						centrosome organization|cilium assembly|G2/M transition of mitotic cell cycle|interkinetic nuclear migration|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome	centriolar satellite|cytosol|nuclear membrane|pericentriolar material	identical protein binding		PCM1/JAK2(30)	haematopoietic_and_lymphoid_tissue(30)|breast(4)|ovary(2)	36				Colorectal(111;0.0789)				T	RET|JAK2	papillary thyroid|CML|MPD								---	---	---	---
ADAM28	10863	broad.mit.edu	37	8	24187195	24187195	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:24187195delA	uc003xdy.2	+						ADAM28_uc003xdx.2_Intron|ADAM28_uc011kzz.1_Intron|ADAM28_uc011laa.1_Intron|ADAM28_uc010lua.2_Intron	NM_014265	NP_055080			ADAM metallopeptidase domain 28 isoform 1						proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|lung(1)|central_nervous_system(1)	5		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)														---	---	---	---
DOCK5	80005	broad.mit.edu	37	8	25240127	25240127	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:25240127delT	uc003xeg.2	+						PPP2R2A_uc003xek.2_Intron|DOCK5_uc003xei.2_Intron|DOCK5_uc003xej.2_Intron	NM_024940	NP_079216			dedicator of cytokinesis 5							cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)														---	---	---	---
DPYSL2	1808	broad.mit.edu	37	8	26513013	26513013	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:26513013delA	uc003xfb.1	+						DPYSL2_uc003xfa.2_Intron|DPYSL2_uc010luk.1_Intron|DPYSL2_uc011lah.1_Intron	NM_001386	NP_001377			dihydropyrimidinase-like 2						axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	dihydropyrimidinase activity|protein binding			large_intestine(1)	1		all_cancers(63;0.121)|Ovarian(32;2.68e-05)|all_epithelial(46;0.116)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;3.33e-10)|Colorectal(74;0.183)														---	---	---	---
PBK	55872	broad.mit.edu	37	8	27698158	27698158	+	5'Flank	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:27698158delA	uc003xgi.2	-						PBK_uc011lap.1_5'Flank	NM_018492	NP_060962			PDZ binding kinase						mitosis		ATP binding|protein binding|protein serine/threonine kinase activity				0		Ovarian(32;0.000953)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0213)|KIRC - Kidney renal clear cell carcinoma(542;0.101)|Kidney(114;0.121)|Colorectal(74;0.141)														---	---	---	---
C8orf80	389643	broad.mit.edu	37	8	27884280	27884282	+	Intron	DEL	TCA	-	-	rs142016219		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:27884280_27884282delTCA	uc003xgm.3	-							NM_001010906	NP_001010906			speckled-like pattern in the germinal center							nucleus	GTP binding|GTPase activity			ovary(1)|central_nervous_system(1)	2		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|KIRC - Kidney renal clear cell carcinoma(542;0.126)|Kidney(114;0.15)|Colorectal(74;0.181)														---	---	---	---
WRN	7486	broad.mit.edu	37	8	30942985	30942985	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:30942985delT	uc003xio.3	+						WRN_uc011lbe.1_Intron|WRN_uc010lvk.2_5'Flank	NM_000553	NP_000544			Werner syndrome protein						base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			ovary(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	7		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)				Mis|N|F|S			osteosarcoma|meningioma|others		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Werner_syndrome				---	---	---	---
C8orf41	80185	broad.mit.edu	37	8	33367554	33367554	+	Intron	DEL	A	-	-	rs79956819		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:33367554delA	uc003xjl.3	-						C8orf41_uc003xjk.3_Intron|C8orf41_uc010lvv.2_Intron|C8orf41_uc003xjm.3_Intron|C8orf41_uc003xjn.1_Intron	NM_025115	NP_079391			hypothetical protein LOC80185								binding				0				KIRC - Kidney renal clear cell carcinoma(67;0.0923)|Kidney(114;0.111)														---	---	---	---
ASH2L	9070	broad.mit.edu	37	8	37968486	37968486	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:37968486delT	uc003xkt.3	+						ASH2L_uc011lbk.1_Intron|ASH2L_uc003xku.3_Intron|ASH2L_uc010lwa.2_Intron	NM_004674	NP_004665			ash2-like isoform a						hemopoiesis|histone H3-K4 methylation|positive regulation of cell proliferation|regulation of transcription, DNA-dependent|response to estrogen stimulus|transcription from RNA polymerase II promoter	Set1C/COMPASS complex	metal ion binding|protein binding|transcription regulatory region DNA binding			ovary(1)|lung(1)	2	Colorectal(12;0.000501)	Lung NSC(58;0.0295)|all_lung(54;0.0413)																---	---	---	---
DDHD2	23259	broad.mit.edu	37	8	38099572	38099572	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:38099572delA	uc003xlb.2	+						DDHD2_uc003xlc.2_Intron|DDHD2_uc011lbl.1_Intron	NM_015214	NP_056029			DDHD domain containing 2 isoform 1						lipid catabolic process	centrosome	hydrolase activity|metal ion binding			large_intestine(1)|ovary(1)	2	Colorectal(12;0.000442)	all_lung(54;0.0657)|Lung NSC(58;0.175)	BRCA - Breast invasive adenocarcinoma(5;3.76e-25)|COAD - Colon adenocarcinoma(9;0.0977)															---	---	---	---
WHSC1L1	54904	broad.mit.edu	37	8	38195854	38195854	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:38195854delA	uc003xli.2	-						WHSC1L1_uc011lbm.1_Intron|WHSC1L1_uc010lwe.2_Intron|WHSC1L1_uc003xlj.2_Intron	NM_023034	NP_075447			WHSC1L1 protein isoform long						cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)	1	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)					T	NUP98	AML								---	---	---	---
ADAM32	203102	broad.mit.edu	37	8	39141291	39141297	+	Intron	DEL	TTTTTTT	-	-	rs67530415		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:39141291_39141297delTTTTTTT	uc003xmt.3	+						ADAM32_uc011lch.1_Intron|ADAM32_uc003xmu.3_Intron|ADAM32_uc003xmv.2_Intron	NM_145004	NP_659441			a disintegrin and metalloprotease domain 32						proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)|kidney(1)	3		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)															---	---	---	---
ADAM18	8749	broad.mit.edu	37	8	39467896	39467897	+	Intron	INS	-	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:39467896_39467897insC	uc003xni.2	+						ADAM18_uc003xnh.2_Intron|ADAM18_uc010lww.2_Intron|ADAM18_uc010lwx.2_Intron	NM_014237	NP_055052			a disintegrin and metalloprotease domain 18						cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)|kidney(1)|skin(1)	6		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)															---	---	---	---
SGK196	84197	broad.mit.edu	37	8	42978201	42978202	+	3'UTR	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:42978201_42978202delTT	uc003xpw.2	+	5						NM_032237	NP_115613			protein kinase-like protein SgK196							integral to membrane	ATP binding|protein kinase activity				0																		---	---	---	---
KIAA0146	23514	broad.mit.edu	37	8	48586205	48586205	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:48586205delT	uc003xqd.2	+						KIAA0146_uc011ldb.1_Intron|KIAA0146_uc010lxs.2_Intron|KIAA0146_uc011ldc.1_Intron|KIAA0146_uc011ldd.1_Intron|KIAA0146_uc003xqe.2_Intron|KIAA0146_uc003xqf.2_Intron|KIAA0146_uc011lde.1_Intron|KIAA0146_uc010lxt.2_Intron|KIAA0146_uc011ldf.1_Intron|KIAA0146_uc011ldg.1_5'UTR|KIAA0146_uc010lxv.1_Intron	NM_001080394	NP_001073863			hypothetical protein LOC23514												0		Lung NSC(58;0.175)																---	---	---	---
PRKDC	5591	broad.mit.edu	37	8	48812834	48812834	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:48812834delA	uc003xqi.2	-						PRKDC_uc003xqj.2_Intron|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835			protein kinase, DNA-activated, catalytic						cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)											NHEJ					---	---	---	---
EFCAB1	79645	broad.mit.edu	37	8	49642082	49642083	+	Intron	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:49642082_49642083delAA	uc003xqo.2	-						EFCAB1_uc003xqn.3_Intron|EFCAB1_uc011ldj.1_Intron|EFCAB1_uc010lxx.2_Intron|EFCAB1_uc011ldk.1_Intron	NM_024593	NP_078869			EF-hand calcium binding domain 1 isoform a								calcium ion binding				0		all_epithelial(80;0.0134)|Lung NSC(129;0.0207)|all_lung(136;0.0464)																---	---	---	---
EFCAB1	79645	broad.mit.edu	37	8	49643852	49643852	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:49643852delT	uc003xqo.2	-						EFCAB1_uc003xqn.3_Intron|EFCAB1_uc011ldj.1_Intron|EFCAB1_uc010lxx.2_Intron|EFCAB1_uc011ldk.1_Intron	NM_024593	NP_078869			EF-hand calcium binding domain 1 isoform a								calcium ion binding				0		all_epithelial(80;0.0134)|Lung NSC(129;0.0207)|all_lung(136;0.0464)																---	---	---	---
SNTG1	54212	broad.mit.edu	37	8	51362183	51362183	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:51362183delT	uc010lxy.1	+						SNTG1_uc003xqs.1_Intron|SNTG1_uc010lxz.1_Intron|SNTG1_uc011ldl.1_Intron	NM_018967	NP_061840			syntrophin, gamma 1						cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)																---	---	---	---
LYN	4067	broad.mit.edu	37	8	56866222	56866222	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:56866222delA	uc003xsk.3	+						LYN_uc003xsl.3_Intron	NM_002350	NP_002341			Yamaguchi sarcoma viral (v-yes-1) oncogene						erythrocyte differentiation|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of cellular component movement|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of tyrosine phosphorylation of STAT protein|response to DNA damage stimulus|T cell costimulation	cytosol|Golgi apparatus|membrane raft|nucleus|perinuclear region of cytoplasm	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|receptor signaling protein tyrosine kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3		all_lung(136;0.0555)|Lung NSC(129;0.0726)|all_epithelial(80;0.0772)	Epithelial(17;0.000834)|all cancers(17;0.00598)															---	---	---	---
CYP7A1	1581	broad.mit.edu	37	8	59412826	59412826	+	5'Flank	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:59412826delA	uc003xtm.3	-							NM_000780	NP_000771			cytochrome P450, family 7, subfamily A,						bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			ovary(1)	1		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)												Neonatal_Giant_Cell_Hepatitis				---	---	---	---
CHD7	55636	broad.mit.edu	37	8	61714076	61714076	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:61714076delT	uc003xue.2	+							NM_017780	NP_060250			chromodomain helicase DNA binding protein 7						central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity	p.556_871dup(1)		ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)															---	---	---	---
CLVS1	157807	broad.mit.edu	37	8	62412295	62412295	+	3'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:62412295delT	uc003xuh.2	+	6					CLVS1_uc003xui.2_RNA|CLVS1_uc010lyp.2_3'UTR	NM_173519	NP_775790			retinaldehyde binding protein 1-like 1						lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			skin(4)|ovary(1)	5																		---	---	---	---
YTHDF3	253943	broad.mit.edu	37	8	64081982	64081982	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:64081982delT	uc003xuy.2	+						YTHDF3_uc010lys.2_Intron|YTHDF3_uc003xuz.2_Intron|YTHDF3_uc003xva.2_Intron|YTHDF3_uc011len.1_Intron	NM_152758	NP_689971			YTH domain family, member 3												0	Breast(64;0.0716)	all_cancers(86;0.169)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.146)	BRCA - Breast invasive adenocarcinoma(89;0.161)															---	---	---	---
CSPP1	79848	broad.mit.edu	37	8	68062340	68062340	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:68062340delA	uc003xxi.2	+						CSPP1_uc003xxg.1_Intron|CSPP1_uc003xxh.1_Intron|CSPP1_uc003xxj.2_Intron|CSPP1_uc003xxk.2_Intron	NM_001077204	NP_001070672			centrosome spindle pole associated protein 1							centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)															---	---	---	---
CPA6	57094	broad.mit.edu	37	8	68396310	68396310	+	Intron	DEL	T	-	-	rs71554608		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:68396310delT	uc003xxq.3	-						CPA6_uc003xxr.3_Intron|CPA6_uc003xxs.2_Intron	NM_020361	NP_065094			carboxypeptidase A6 isoform 1 precursor						proteolysis	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2			Epithelial(68;0.04)|OV - Ovarian serous cystadenocarcinoma(28;0.0593)|all cancers(69;0.136)															---	---	---	---
UBE2W	55284	broad.mit.edu	37	8	74737352	74737352	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:74737352delA	uc003xzv.2	-						UBE2W_uc003xzt.2_Intron|UBE2W_uc003xzu.2_Intron|UBE2W_uc003xzw.2_Intron	NM_018299	NP_060769			ubiquitin-conjugating enzyme E2W (putative)						protein K11-linked ubiquitination|protein monoubiquitination		ATP binding|protein binding|ubiquitin-protein ligase activity				0	Breast(64;0.0311)		Epithelial(68;0.0235)|all cancers(69;0.0687)|BRCA - Breast invasive adenocarcinoma(89;0.069)															---	---	---	---
CRISPLD1	83690	broad.mit.edu	37	8	75929747	75929747	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:75929747delT	uc003yan.2	+						CRISPLD1_uc011lfk.1_Intron|CRISPLD1_uc011lfl.1_Intron	NM_031461	NP_113649			cysteine-rich secretory protein LCCL domain							extracellular region				ovary(1)|central_nervous_system(1)	2	Breast(64;0.0799)		Epithelial(68;0.155)|BRCA - Breast invasive adenocarcinoma(89;0.161)															---	---	---	---
Unknown	0	broad.mit.edu	37	8	81472059	81472059	+	IGR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:81472059delA								ZBTB10 (37451 upstream) : ZNF704 (78710 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	8	82530375	82530375	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:82530375delT								FABP12 (86825 upstream) : IMPA1 (38776 downstream)																																			---	---	---	---
OSGIN2	734	broad.mit.edu	37	8	90921779	90921780	+	Intron	DEL	TT	-	-	rs73696834	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:90921779_90921780delTT	uc003yeg.2	+						OSGIN2_uc003yeh.2_Intron	NM_004337	NP_004328			oxidative stress induced growth inhibitor family						germ cell development|meiosis						0			BRCA - Breast invasive adenocarcinoma(11;0.0344)															---	---	---	---
OSGIN2	734	broad.mit.edu	37	8	90936586	90936586	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:90936586delT	uc003yeg.2	+						OSGIN2_uc003yeh.2_Intron	NM_004337	NP_004328			oxidative stress induced growth inhibitor family						germ cell development|meiosis						0			BRCA - Breast invasive adenocarcinoma(11;0.0344)															---	---	---	---
RUNX1T1	862	broad.mit.edu	37	8	93088475	93088475	+	5'Flank	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:93088475delA	uc003yfd.2	-						RUNX1T1_uc003yfe.1_Intron|RUNX1T1_uc010mao.2_Intron|RUNX1T1_uc011lgi.1_Intron|RUNX1T1_uc003yfh.1_Intron	NM_175634	NP_783552			acute myelogenous leukemia 1 translocation 1						generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)															---	---	---	---
Unknown	0	broad.mit.edu	37	8	94969529	94969529	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:94969529delT								PDP1 (31235 upstream) : CDH17 (169865 downstream)																																			---	---	---	---
KIAA1429	25962	broad.mit.edu	37	8	95541687	95541687	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:95541687delA	uc003ygo.1	-						KIAA1429_uc003ygp.2_Intron|KIAA1429_uc010maz.1_5'Flank	NM_015496	NP_056311			hypothetical protein LOC25962 isoform 1						mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)															---	---	---	---
KIAA1429	25962	broad.mit.edu	37	8	95549547	95549547	+	Intron	DEL	A	-	-	rs2304765	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:95549547delA	uc003ygo.1	-						KIAA1429_uc003ygp.2_Intron	NM_015496	NP_056311			hypothetical protein LOC25962 isoform 1						mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)															---	---	---	---
C8orf38	137682	broad.mit.edu	37	8	96060797	96060797	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:96060797delT	uc003yhj.2	+						C8orf38_uc003yhe.1_RNA|C8orf38_uc003yhf.2_Intron|C8orf38_uc011lgs.1_Intron|C8orf38_uc003yhi.2_Intron|C8orf38_uc003yhk.2_Intron|C8orf38_uc003yhl.2_Intron	NM_152416	NP_689629			hypothetical protein LOC137682 precursor						biosynthetic process	mitochondrion	transferase activity				0	Breast(36;3.32e-06)																	---	---	---	---
GDF6	392255	broad.mit.edu	37	8	97172304	97172304	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:97172304delG	uc003yhp.2	-							NM_001001557	NP_001001557			growth differentiation factor 6 precursor						activin receptor signaling pathway|BMP signaling pathway|growth|pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(1)|breast(1)|pancreas(1)	3	Breast(36;2.67e-05)																	---	---	---	---
MTDH	92140	broad.mit.edu	37	8	98698791	98698791	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:98698791delT	uc003yhz.2	+							NM_178812	NP_848927			metadherin						lipopolysaccharide-mediated signaling pathway|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of angiogenesis|positive regulation of autophagy|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein kinase B signaling cascade	apical plasma membrane|endoplasmic reticulum membrane|integral to membrane|intercellular canaliculus|nuclear body|nuclear membrane|nucleolus|perinuclear region of cytoplasm|tight junction	NF-kappaB binding|RNA polymerase II transcription factor binding|transcription coactivator activity			liver(1)|central_nervous_system(1)	2	Breast(36;2.56e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.178)															---	---	---	---
POP1	10940	broad.mit.edu	37	8	99148630	99148630	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:99148630delA	uc003yij.3	+						POP1_uc011lgv.1_Intron|POP1_uc003yik.2_Intron	NM_001145860	NP_001139332			processing of precursor 1						tRNA 5'-leader removal|tRNA catabolic process	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease MRP activity|ribonuclease P activity			ovary(1)|breast(1)	2	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.145)															---	---	---	---
OSR2	116039	broad.mit.edu	37	8	99962748	99962748	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:99962748delA	uc003yir.2	+						OSR2_uc010mbn.2_Intron|OSR2_uc003yiq.2_Intron|OSR2_uc011lgx.1_Intron	NM_001142462	NP_001135934			odd-skipped related 2 isoform a						bone morphogenesis|chondrocyte differentiation|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic leg joint morphogenesis|embryonic skeletal joint morphogenesis|eyelid development in camera-type eye|head development|mesonephros development|metanephros development|middle ear morphogenesis|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|osteoblast proliferation|palate development|positive regulation of bone mineralization|positive regulation of epithelial cell proliferation|positive regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|zinc ion binding			central_nervous_system(1)	1	Breast(36;4.14e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.0136)															---	---	---	---
VPS13B	157680	broad.mit.edu	37	8	100832521	100832521	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:100832521delT	uc003yiv.2	+						VPS13B_uc003yiw.2_Intron	NM_017890	NP_060360			vacuolar protein sorting 13B isoform 5						protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)															---	---	---	---
UBR5	51366	broad.mit.edu	37	8	103311358	103311358	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:103311358delT	uc003ykr.1	-						UBR5_uc003yks.1_Intron	NM_015902	NP_056986			ubiquitin protein ligase E3 component n-recognin						cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)															---	---	---	---
DCAF13	25879	broad.mit.edu	37	8	104439487	104439487	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:104439487delT	uc003yln.2	+						DCAF13_uc003ylm.1_Intron|DCAF13_uc003ylo.2_Intron	NM_015420	NP_056235			WD repeats and SOF1 domain containing						rRNA processing	CUL4 RING ubiquitin ligase complex|nucleolus|ribonucleoprotein complex				breast(1)	1																		---	---	---	---
ANGPT1	284	broad.mit.edu	37	8	108359001	108359001	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:108359001delA	uc003ymn.2	-						ANGPT1_uc003ymo.2_Intron	NM_001146	NP_001137			angiopoietin 1 precursor						activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|blood coagulation|cell differentiation|heparin biosynthetic process|leukocyte migration|negative regulation of cell adhesion|negative regulation of endothelial cell apoptosis|negative regulation of vascular permeability|positive chemotaxis|positive regulation of blood vessel endothelial cell migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|positive regulation of receptor internalization|protein localization at cell surface|regulation of satellite cell proliferation|sprouting angiogenesis|Tie receptor signaling pathway	extracellular space|membrane raft|microvillus|plasma membrane	receptor tyrosine kinase binding			ovary(3)|skin(3)|upper_aerodigestive_tract(1)	7	Breast(1;5.06e-08)		OV - Ovarian serous cystadenocarcinoma(57;5.53e-09)															---	---	---	---
PKHD1L1	93035	broad.mit.edu	37	8	110460747	110460747	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:110460747delT	uc003yne.2	+							NM_177531	NP_803875			fibrocystin L precursor						immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)												HNSCC(38;0.096)			---	---	---	---
CSMD3	114788	broad.mit.edu	37	8	113694474	113694474	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:113694474delA	uc003ynu.2	-						CSMD3_uc003yns.2_Intron|CSMD3_uc003ynt.2_Intron|CSMD3_uc011lhx.1_Intron	NM_198123	NP_937756			CUB and Sushi multiple domains 3 isoform 1							integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63															HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			---	---	---	---
RAD21	5885	broad.mit.edu	37	8	117869182	117869182	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:117869182delA	uc003yod.2	-							NM_006265	NP_006256			RAD21 homolog						apoptosis|cell division|chromosome segregation|double-strand break repair|mitotic metaphase/anaphase transition|mitotic prometaphase|protein localization to chromatin|reciprocal meiotic recombination|regulation of transcription from RNA polymerase II promoter	chromosome, centromeric region|cohesin complex|nuclear chromosome|nucleoplasm	protein binding			lung(1)|skin(1)	2	all_cancers(13;1.21e-21)|Lung NSC(37;0.000134)|Ovarian(258;0.0172)																	---	---	---	---
ENPP2	5168	broad.mit.edu	37	8	120613134	120613134	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:120613134delT	uc003yot.1	-						ENPP2_uc003yos.1_Intron|ENPP2_uc010mdd.1_Intron	NM_001040092	NP_001035181			autotaxin isoform 2 preproprotein						cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)|kidney(1)	7	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)															---	---	---	---
SNTB1	6641	broad.mit.edu	37	8	121823372	121823372	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:121823372delC	uc010mdg.2	-						SNTB1_uc003ype.2_Intron	NM_021021	NP_066301			basic beta 1 syntrophin						muscle contraction	cell junction|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|calmodulin binding			skin(5)	5	Lung NSC(37;4.46e-09)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)		STAD - Stomach adenocarcinoma(47;0.00503)															---	---	---	---
TMEM71	137835	broad.mit.edu	37	8	133770855	133770855	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:133770855delA	uc003ytp.2	-						TMEM71_uc003ytn.2_Intron|TMEM71_uc003yto.2_Intron	NM_144649	NP_653250			transmembrane protein 71 isoform 1							integral to membrane				ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)															---	---	---	---
TG	7038	broad.mit.edu	37	8	133879441	133879441	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:133879441delT	uc003ytw.2	+							NM_003235	NP_003226			thyroglobulin precursor						hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)														---	---	---	---
PTK2	5747	broad.mit.edu	37	8	141810338	141810338	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:141810338delT	uc003yvu.2	-						PTK2_uc011ljq.1_Intron|PTK2_uc003yvp.2_Intron|PTK2_uc003yvq.2_Intron|PTK2_uc003yvr.2_Intron|PTK2_uc003yvs.2_Intron|PTK2_uc003yvt.2_Intron|PTK2_uc003yvv.2_Intron|PTK2_uc011ljr.1_Intron	NM_153831	NP_722560			PTK2 protein tyrosine kinase 2 isoform a						axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)															---	---	---	---
PTK2	5747	broad.mit.edu	37	8	141843275	141843275	+	Intron	DEL	A	-	-	rs141534503		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:141843275delA	uc003yvu.2	-						PTK2_uc003yvq.2_Intron|PTK2_uc003yvr.2_Intron|PTK2_uc003yvs.2_Intron|PTK2_uc003yvt.2_Intron|PTK2_uc003yvv.2_Intron|PTK2_uc011ljr.1_Intron	NM_153831	NP_722560			PTK2 protein tyrosine kinase 2 isoform a						axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)															---	---	---	---
SLC45A4	57210	broad.mit.edu	37	8	142229177	142229177	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:142229177delG	uc003ywd.1	-						SLC45A4_uc003ywc.1_Intron|SLC45A4_uc010meq.1_Intron	NM_001080431	NP_001073900			solute carrier family 45, member 4						transport	integral to membrane				ovary(2)	2	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)															---	---	---	---
RECQL4	9401	broad.mit.edu	37	8	145738582	145738584	+	Intron	DEL	GGG	-	-	rs67678060		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145738582_145738584delGGG	uc003zdj.2	-							NM_004260	NP_004251			RecQ protein-like 4						DNA duplex unwinding|DNA recombination|DNA repair	cytoplasm|nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|DNA strand annealing activity|zinc ion binding			breast(2)|lung(1)|skin(1)	4	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)					N|F|S			osteosarcoma|skin basal and sqamous cell		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	RAPADILINO_syndrome|Rothmund-Thomson_syndrome|Baller-Gerold_syndrome				---	---	---	---
SMARCA2	6595	broad.mit.edu	37	9	2101629	2101629	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:2101629delT	uc003zhc.2	+						SMARCA2_uc003zhd.2_Intron|SMARCA2_uc010mha.2_Intron	NM_003070	NP_003061			SWI/SNF-related matrix-associated						chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)														---	---	---	---
SMARCA2	6595	broad.mit.edu	37	9	2161562	2161562	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:2161562delT	uc003zhc.2	+						SMARCA2_uc003zhd.2_Intron|SMARCA2_uc010mha.2_Intron|SMARCA2_uc011llw.1_Intron|SMARCA2_uc003zhf.2_Intron|SMARCA2_uc011llx.1_Intron|SMARCA2_uc003zhe.2_Intron|SMARCA2_uc003zhg.2_Intron|SMARCA2_uc010mhb.2_Intron	NM_003070	NP_003061			SWI/SNF-related matrix-associated						chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)														---	---	---	---
GLIS3	169792	broad.mit.edu	37	9	3856308	3856308	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:3856308delA	uc003zhw.1	-						GLIS3_uc003zhx.1_Intron|GLIS3_uc010mhf.1_Intron|GLIS3_uc003zhv.1_Intron|GLIS3_uc003zhy.1_Intron	NM_152629	NP_689842			GLIS family zinc finger 3 isoform b						negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)														---	---	---	---
GLIS3	169792	broad.mit.edu	37	9	4126054	4126054	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:4126054delT	uc003zhw.1	-						GLIS3_uc003zhx.1_Intron|GLIS3_uc003zic.1_Intron|GLIS3_uc003zie.1_Intron|GLIS3_uc010mhh.1_Intron|GLIS3_uc003zid.1_Intron|GLIS3_uc010mhi.1_Intron|GLIS3_uc003zif.1_Intron|GLIS3_uc003zig.1_Intron|GLIS3_uc003zih.1_Intron|GLIS3_uc003zib.1_Intron|GLIS3_uc010mhg.1_Intron	NM_152629	NP_689842			GLIS family zinc finger 3 isoform b						negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)														---	---	---	---
SLC1A1	6505	broad.mit.edu	37	9	4567618	4567618	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:4567618delA	uc003zij.1	+						C9orf68_uc003zik.2_Intron	NM_004170	NP_004161			solute carrier family 1, member 1						D-aspartate import|L-glutamate import|synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity				0		Acute lymphoblastic leukemia(2;0.0359)|Breast(48;0.0457)		GBM - Glioblastoma multiforme(50;0.0124)|Lung(218;0.183)	L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)													---	---	---	---
RCL1	10171	broad.mit.edu	37	9	4841040	4841040	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:4841040delT	uc003zis.2	+						RCL1_uc003zit.2_Intron|RCL1_uc010mhk.1_Intron|RCL1_uc010mhl.1_Intron	NM_005772	NP_005763			RNA terminal phosphate cyclase-like 1						ribosome biogenesis|RNA processing	nucleolus	RNA-3'-phosphate cyclase activity				0	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0206)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0244)														---	---	---	---
KIAA1432	57589	broad.mit.edu	37	9	5756539	5756539	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:5756539delA	uc003zji.2	+						KIAA1432_uc003zjh.2_Intron|KIAA1432_uc003zjl.3_Intron|KIAA1432_uc003zjj.1_Intron	NM_020829	NP_065880			connexin 43-interacting protein 150 isoform a							integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)														---	---	---	---
IL33	90865	broad.mit.edu	37	9	6254567	6254568	+	Intron	DEL	AT	-	-	rs60420792		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:6254567_6254568delAT	uc003zjt.2	+						IL33_uc011lmg.1_Intron|IL33_uc011lmh.1_Intron|IL33_uc003zju.1_Intron	NM_033439	NP_254274			interleukin 33 precursor						positive regulation of chemokine secretion|positive regulation of inflammatory response|positive regulation of macrophage activation|positive regulation of transcription from RNA polymerase II promoter	extracellular space	cytokine activity				0		Acute lymphoblastic leukemia(23;0.158)|Prostate(43;0.167)		GBM - Glioblastoma multiforme(50;0.0161)|Lung(218;0.105)														---	---	---	---
UHRF2	115426	broad.mit.edu	37	9	6497190	6497190	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:6497190delT	uc003zjy.2	+						UHRF2_uc003zjz.2_Intron|UHRF2_uc003zkb.2_Intron	NM_152896	NP_690856			ubiquitin-like with PHD and ring finger domains						cell cycle|cell differentiation|cell proliferation|protein autoubiquitination|regulation of cell cycle|ubiquitin-dependent protein catabolic process	nucleus	DNA binding|histone binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0392)|Lung(218;0.129)														---	---	---	---
PTPRD	5789	broad.mit.edu	37	9	8501114	8501114	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:8501114delA	uc003zkk.2	-						PTPRD_uc003zkp.2_Intron|PTPRD_uc003zkq.2_Intron|PTPRD_uc003zkr.2_Intron|PTPRD_uc003zks.2_Intron|PTPRD_uc003zkl.2_Intron|PTPRD_uc003zkm.2_Intron|PTPRD_uc003zkn.2_Intron|PTPRD_uc003zko.2_Intron	NM_002839	NP_002830			protein tyrosine phosphatase, receptor type, D						transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)											TSP Lung(15;0.13)			---	---	---	---
PSIP1	11168	broad.mit.edu	37	9	15487004	15487004	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:15487004delT	uc003zlv.3	-						PSIP1_uc003zlw.3_Intron|PSIP1_uc003zlz.3_Intron|PSIP1_uc003zma.3_Intron|PSIP1_uc003zly.2_Intron	NM_033222	NP_150091			PC4 and SFRS1 interacting protein 1 isoform 2						initiation of viral infection|interspecies interaction between organisms|nuclear mRNA 5'-splice site recognition|provirus integration|regulation of transcription, DNA-dependent|response to heat|response to oxidative stress|transcription, DNA-dependent	cytosol|nuclear heterochromatin|nuclear periphery|nucleoplasm|nucleoplasm|transcriptionally active chromatin	activating transcription factor binding|chromatin binding|DNA secondary structure binding|RNA polymerase II transcription coactivator activity			breast(1)	1				GBM - Glioblastoma multiforme(50;2.38e-06)														---	---	---	---
HAUS6	54801	broad.mit.edu	37	9	19063047	19063047	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:19063047delT	uc003znk.2	-	14	1841	c.1588delA	c.(1588-1590)AGTfs	p.S530fs	HAUS6_uc011lmz.1_Frame_Shift_Del_p.S250fs|HAUS6_uc003znl.1_Frame_Shift_Del_p.S394fs|HAUS6_uc003znm.1_Frame_Shift_Del_p.S285fs	NM_017645	NP_060115	Q7Z4H7	HAUS6_HUMAN	HAUS augmin-like complex, subunit 6	530					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|nucleus|spindle				ovary(2)	2																		---	---	---	---
HAUS6	54801	broad.mit.edu	37	9	19082750	19082750	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:19082750delA	uc003znk.2	-						HAUS6_uc011lmz.1_Intron|HAUS6_uc003znl.1_Intron|HAUS6_uc003znm.1_Intron	NM_017645	NP_060115			HAUS augmin-like complex, subunit 6						cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|nucleus|spindle				ovary(2)	2																		---	---	---	---
DENND4C	55667	broad.mit.edu	37	9	19336564	19336565	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:19336564_19336565insT	uc003znq.2	+						DENND4C_uc011lnc.1_Intron|DENND4C_uc011lnd.1_5'Flank	NM_017925	NP_060395			DENN/MADD domain containing 4C							integral to membrane				ovary(1)|skin(1)	2																		---	---	---	---
DENND4C	55667	broad.mit.edu	37	9	19350680	19350680	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:19350680delT	uc003znq.2	+						DENND4C_uc011lnc.1_Intron|DENND4C_uc011lnd.1_Intron|DENND4C_uc003znr.2_Intron|DENND4C_uc003zns.2_Intron|DENND4C_uc003znt.2_Intron	NM_017925	NP_060395			DENN/MADD domain containing 4C							integral to membrane				ovary(1)|skin(1)	2																		---	---	---	---
KIAA1797	54914	broad.mit.edu	37	9	20917058	20917058	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:20917058delT	uc003zog.1	+						KIAA1797_uc003zoh.1_Intron	NM_017794	NP_060264			hypothetical protein LOC54914							integral to membrane	binding			ovary(8)|breast(1)|kidney(1)	10				GBM - Glioblastoma multiforme(3;2.1e-125)|Lung(42;2.76e-14)|LUSC - Lung squamous cell carcinoma(42;1.99e-11)														---	---	---	---
ELAVL2	1993	broad.mit.edu	37	9	23731001	23731001	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:23731001delA	uc003zpu.2	-						ELAVL2_uc003zps.2_Intron|ELAVL2_uc003zpt.2_Intron|ELAVL2_uc003zpv.2_Intron|ELAVL2_uc003zpw.2_Intron	NM_004432	NP_004423			ELAV (embryonic lethal, abnormal vision,						regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)														---	---	---	---
CHMP5	51510	broad.mit.edu	37	9	33270523	33270523	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:33270523delT	uc003zsl.3	+						SUGT1P1_uc010mjq.1_Intron|CHMP5_uc003zsm.3_Intron|CHMP5_uc011lnv.1_Intron|CHMP5_uc003zsn.2_5'Flank	NM_016410	NP_057494			chromatin modifying protein 5						cellular membrane organization|protein transport	cytosol|endosome membrane	protein binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.00506)															---	---	---	---
DNAI1	27019	broad.mit.edu	37	9	34512304	34512304	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:34512304delC	uc003zum.2	+							NM_012144	NP_036276			dynein, axonemal, intermediate chain 1						cell projection organization	cilium axoneme|cytoplasm|dynein complex|microtubule	motor activity				0	all_epithelial(49;0.244)		LUSC - Lung squamous cell carcinoma(29;0.0107)|STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.0222)										Kartagener_syndrome				---	---	---	---
CA9	768	broad.mit.edu	37	9	35677613	35677613	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:35677613delA	uc003zxo.3	+						C9orf100_uc003zxl.2_5'Flank|CA9_uc003zxp.3_Intron	NM_001216	NP_001207			carbonic anhydrase IX precursor						one-carbon metabolic process	integral to membrane|microvillus membrane|nucleolus	carbonate dehydratase activity|zinc ion binding			ovary(4)|skin(1)	5	all_epithelial(49;0.217)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)															---	---	---	---
OR2S2	56656	broad.mit.edu	37	9	35957386	35957386	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:35957386delT	uc011lpi.1	-	1	766	c.710delA	c.(709-711)AAGfs	p.K237fs		NM_019897	NP_063950	Q9NQN1	OR2S1_HUMAN	olfactory receptor, family 2, subfamily S,	237	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00613)|STAD - Stomach adenocarcinoma(86;0.194)															---	---	---	---
RECK	8434	broad.mit.edu	37	9	36091373	36091374	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:36091373_36091374insT	uc003zyv.2	+						RECK_uc003zyw.2_Intron|RECK_uc003zyx.2_Intron	NM_021111	NP_066934			RECK protein precursor							anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)	3			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)															---	---	---	---
RNF38	152006	broad.mit.edu	37	9	36339947	36339948	+	Intron	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:36339947_36339948delTT	uc003zzh.2	-						RNF38_uc003zzi.2_Intron|RNF38_uc003zzj.2_Intron|RNF38_uc003zzk.2_Intron|RNF38_uc003zzl.2_Intron|RNF38_uc003zzm.2_Intron	NM_022781	NP_073618			ring finger protein 38 isoform 1								zinc ion binding			central_nervous_system(1)	1			STAD - Stomach adenocarcinoma(86;0.228)															---	---	---	---
MELK	9833	broad.mit.edu	37	9	36671220	36671220	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:36671220delT	uc003zzn.2	+						MELK_uc011lpm.1_Intron|MELK_uc011lpn.1_Intron|MELK_uc011lpo.1_Intron|MELK_uc010mll.2_Intron|MELK_uc011lpp.1_Intron|MELK_uc010mlm.2_Intron|MELK_uc011lpq.1_Intron|MELK_uc011lpr.1_Intron|MELK_uc011lps.1_Intron	NM_014791	NP_055606			maternal embryonic leucine zipper kinase							cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6		Acute lymphoblastic leukemia(2;1.09e-08)|all_hematologic(2;8.15e-06)	STAD - Stomach adenocarcinoma(86;0.228)															---	---	---	---
ZCCHC7	84186	broad.mit.edu	37	9	37305523	37305524	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:37305523_37305524insT	uc003zzq.2	+						ZCCHC7_uc011lqh.1_Intron|ZCCHC7_uc011lqi.1_Intron|ZCCHC7_uc010mlt.2_Intron	NM_032226	NP_115602			zinc finger, CCHC domain containing 7								nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(29;0.0137)														---	---	---	---
Unknown	0	broad.mit.edu	37	9	39817161	39817161	+	IGR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:39817161delA								LOC653501 (308273 upstream) : FAM74A1 (83039 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	9	66960593	66960594	+	IGR	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:66960593_66960594insT								LOC442421 (457566 upstream) : AQP7P1 (293673 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	9	67029287	67029287	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:67029287delA	uc004aek.1	-											Homo sapiens cDNA FLJ23618 fis, clone ADSE00670.																														---	---	---	---
ANKRD20A3	441425	broad.mit.edu	37	9	67964992	67964993	+	Intron	INS	-	CTTA	CTTA			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:67964992_67964993insCTTA	uc004aeu.2	+						ANKRD20A3_uc010mnn.2_Intron	NM_001012419	NP_001012419			ankyrin repeat domain 20 family, member A3												0																		---	---	---	---
ANKRD20A3	441425	broad.mit.edu	37	9	67966645	67966645	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:67966645delA	uc004aeu.2	+	14	1481	c.1369delA	c.(1369-1371)AAAfs	p.K457fs	ANKRD20A3_uc010mnn.2_Frame_Shift_Del_p.K456fs	NM_001012419	NP_001012419	Q5VUR7	A20A3_HUMAN	ankyrin repeat domain 20 family, member A3	457	Potential.										0																		---	---	---	---
TMC1	117531	broad.mit.edu	37	9	75404223	75404223	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:75404223delA	uc004aiz.1	+	15	1754	c.1214delA	c.(1213-1215)GAAfs	p.E405fs	TMC1_uc010moz.1_Frame_Shift_Del_p.E363fs|TMC1_uc004aja.1_RNA|TMC1_uc004ajb.1_RNA|TMC1_uc004ajc.1_Frame_Shift_Del_p.E259fs|TMC1_uc010mpa.1_Frame_Shift_Del_p.E259fs	NM_138691	NP_619636	Q8TDI8	TMC1_HUMAN	transmembrane channel-like 1	405	Extracellular (Potential).				sensory perception of sound	integral to membrane				ovary(1)	1																		---	---	---	---
PCSK5	5125	broad.mit.edu	37	9	78547258	78547258	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:78547258delT	uc004ajz.2	+						PCSK5_uc004ajy.2_Intron|PCSK5_uc004aka.2_Intron	NM_006200	NP_006191			proprotein convertase subtilisin/kexin type 5						anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3																		---	---	---	---
PCSK5	5125	broad.mit.edu	37	9	78794417	78794417	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:78794417delA	uc004ajz.2	+						PCSK5_uc004aka.2_Intron|PCSK5_uc004akb.2_5'Flank	NM_006200	NP_006191			proprotein convertase subtilisin/kexin type 5						anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3																		---	---	---	---
PCSK5	5125	broad.mit.edu	37	9	78803334	78803334	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:78803334delA	uc004ajz.2	+						PCSK5_uc004aka.2_Intron|PCSK5_uc004akb.2_Intron	NM_006200	NP_006191			proprotein convertase subtilisin/kexin type 5						anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3																		---	---	---	---
TLE4	7091	broad.mit.edu	37	9	82269146	82269148	+	Intron	DEL	TTT	-	-	rs35639126		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:82269146_82269148delTTT	uc004ald.2	+						TLE4_uc004alc.2_Intron|TLE4_uc010mpr.2_Intron|TLE4_uc004ale.2_Intron|TLE4_uc011lsq.1_Intron|TLE4_uc010mps.2_Intron|TLE4_uc004alf.2_Intron	NM_007005	NP_008936			transducin-like enhancer protein 4											lung(2)|ovary(1)|breast(1)|skin(1)	5																		---	---	---	---
TLE1	7088	broad.mit.edu	37	9	84248346	84248346	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:84248346delA	uc004aly.2	-						TLE1_uc004alz.2_Intron|TLE1_uc011lsr.1_Intron|TLE1_uc004ama.1_Intron|TLE1_uc011lss.1_Intron	NM_005077	NP_005068			transducin-like enhancer protein 1						negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			ovary(1)|skin(1)	2																		---	---	---	---
NTRK2	4915	broad.mit.edu	37	9	87636093	87636093	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:87636093delT	uc004aoa.1	+						NTRK2_uc004anz.1_Intron	NM_001018064	NP_001018074			neurotrophic tyrosine kinase, receptor, type 2						activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			lung(11)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|liver(1)	16															TSP Lung(25;0.17)			---	---	---	---
Unknown	0	broad.mit.edu	37	9	88370966	88370966	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:88370966delT								AGTPBP1 (14022 upstream) : NAA35 (185091 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	9	88437680	88437680	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:88437680delA	uc004aog.1	+						uc004aoh.1_Intron					Homo sapiens cDNA FLJ42532 fis, clone BRACE3003004.																														---	---	---	---
NAA35	60560	broad.mit.edu	37	9	88576799	88576799	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:88576799delT	uc004aoi.3	+						NAA35_uc004aoj.3_Intron|NAA35_uc004aok.1_Intron	NM_024635	NP_078911			corneal wound healing-related protein						smooth muscle cell proliferation	cytoplasm|nucleus|plasma membrane				skin(2)|central_nervous_system(1)	3																		---	---	---	---
ZCCHC6	79670	broad.mit.edu	37	9	88938961	88938961	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:88938961delA	uc004aoq.2	-						ZCCHC6_uc011ltf.1_Intron|ZCCHC6_uc004aor.2_Intron|ZCCHC6_uc004aos.2_Intron|ZCCHC6_uc004aot.2_Intron|ZCCHC6_uc004aou.2_Intron	NM_024617	NP_078893			zinc finger, CCHC domain containing 6						RNA 3'-end processing		nucleic acid binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)	2																		---	---	---	---
DAPK1	1612	broad.mit.edu	37	9	90219825	90219825	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:90219825delT	uc004apc.2	+						DAPK1_uc004ape.2_Intron|DAPK1_uc004apd.2_Intron|DAPK1_uc011ltg.1_Intron|DAPK1_uc011lth.1_Intron	NM_004938	NP_004929			death-associated protein kinase 1						apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			ovary(1)|breast(1)	2														Chronic_Lymphocytic_Leukemia_Familial_Clustering_of				---	---	---	---
SHC3	53358	broad.mit.edu	37	9	91653328	91653328	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:91653328delA	uc004aqg.2	-							NM_016848	NP_058544			src homology 2 domain-containing transforming						central nervous system development|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	protein binding|signal transducer activity			lung(3)|skin(1)	4																		---	---	---	---
ROR2	4920	broad.mit.edu	37	9	94488677	94488677	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:94488677delA	uc004arj.1	-						ROR2_uc004ari.1_Intron	NM_004560	NP_004551			receptor tyrosine kinase-like orphan receptor 2						negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			lung(8)|central_nervous_system(5)|ovary(3)|large_intestine(2)|stomach(1)|breast(1)	20																		---	---	---	---
IARS	3376	broad.mit.edu	37	9	95003101	95003101	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:95003101delA	uc004art.1	-						IARS_uc004ars.1_Intron|IARS_uc004aru.3_Intron|IARS_uc010mqr.2_Intron|IARS_uc010mqt.2_Intron	NM_013417	NP_038203			isoleucine tRNA synthetase						isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			ovary(1)|skin(1)	2					L-Isoleucine(DB00167)													---	---	---	---
ECM2	1842	broad.mit.edu	37	9	95262904	95262904	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:95262904delT	uc004ash.2	-						CENPP_uc004arz.2_Intron|CENPP_uc010mqx.2_Intron|ECM2_uc004asf.3_Intron|ECM2_uc011lty.1_Intron|ECM2_uc004asg.2_Intron|ECM2_uc010mqz.1_Intron	NM_001393	NP_001384			extracellular matrix protein 2 precursor						cell-matrix adhesion		integrin binding			ovary(1)|skin(1)	2																		---	---	---	---
PHF2	5253	broad.mit.edu	37	9	96422612	96422612	+	Frame_Shift_Del	DEL	A	-	-	rs76832193		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:96422612delA	uc004aub.2	+	12	1615	c.1468delA	c.(1468-1470)AAAfs	p.K490fs	PHF2_uc011lug.1_Frame_Shift_Del_p.K373fs|PHF2_uc004auc.2_5'Flank	NM_005392	NP_005383	O75151	PHF2_HUMAN	PHD finger protein 2	490	Pro-rich.|Lys-rich.				liver development|negative regulation of chromatin silencing at rDNA|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K9 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;9.11e-28)														---	---	---	---
HIATL1	84641	broad.mit.edu	37	9	97218372	97218373	+	Intron	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:97218372_97218373delAA	uc004aur.2	+						HIATL1_uc011luh.1_Intron	NM_032558	NP_115947			hippocampus abundant transcript-like 1						transmembrane transport	integral to membrane|plasma membrane	protein binding|transporter activity			ovary(2)	2		Acute lymphoblastic leukemia(62;0.136)																---	---	---	---
HIATL2	84278	broad.mit.edu	37	9	99721302	99721302	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:99721302delA	uc004aws.2	-						HIATL2_uc004awr.1_Intron	NR_002894				RecName: Full=Hippocampus abundant transcript-like protein 2;												0																		---	---	---	---
KIAA1529	57653	broad.mit.edu	37	9	100126013	100126014	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:100126013_100126014insT	uc011lut.1	+						KIAA1529_uc004axe.1_Intron|KIAA1529_uc004axg.1_Intron|KIAA1529_uc004axh.1_Intron|KIAA1529_uc011luw.1_Intron|MIR1302-8_hsa-mir-1302-8|MI0006369_5'Flank	NM_020893	NP_065944			hypothetical protein LOC57653											ovary(4)|large_intestine(2)|skin(1)	7		Acute lymphoblastic leukemia(62;0.154)																---	---	---	---
HEMGN	55363	broad.mit.edu	37	9	100700506	100700506	+	5'UTR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:100700506delA	uc004axy.2	-	1					HEMGN_uc004axz.2_Intron	NM_197978	NP_932095			hemogen						cell differentiation|multicellular organismal development					ovary(1)	1		Acute lymphoblastic leukemia(62;0.0559)																---	---	---	---
TMEFF1	8577	broad.mit.edu	37	9	103323993	103323993	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:103323993delT	uc004baz.1	+						TMEFF1_uc004bay.1_Intron	NM_003692	NP_003683			transmembrane protein with EGF-like and two						multicellular organismal development	integral to membrane|plasma membrane					0		Acute lymphoblastic leukemia(62;0.0452)																---	---	---	---
MRPL50	54534	broad.mit.edu	37	9	104152596	104152596	+	3'UTR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:104152596delA	uc004bbe.2	-	2					MRPL50_uc011lvj.1_Intron	NM_019051	NP_061924			mitochondrial ribosomal protein L50							mitochondrion|ribosome					0		Acute lymphoblastic leukemia(62;0.0559)																---	---	---	---
SMC2	10592	broad.mit.edu	37	9	106901627	106901627	+	3'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:106901627delT	uc004bbv.2	+	25					SMC2_uc004bbw.2_3'UTR|SMC2_uc011lvl.1_3'UTR|SMC2_uc004bbx.2_3'UTR|SMC2_uc004bby.2_RNA	NM_001042551	NP_001036016			structural maintenance of chromosomes 2						cell division|mitotic chromosome condensation|symbiosis, encompassing mutualism through parasitism	condensin complex|cytoplasm|nuclear chromosome	ATP binding|protein heterodimerization activity			ovary(4)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|breast(1)	9																		---	---	---	---
ZNF462	58499	broad.mit.edu	37	9	109736291	109736291	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:109736291delT	uc004bcz.2	+						ZNF462_uc010mto.2_Intron|ZNF462_uc004bda.2_Intron|ZNF462_uc011lvz.1_Intron|ZNF462_uc004bdb.1_Intron	NM_021224	NP_067047			zinc finger protein 462						transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5																		---	---	---	---
IKBKAP	8518	broad.mit.edu	37	9	111665955	111665955	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:111665955delA	uc004bdm.3	-						IKBKAP_uc004bdl.2_Intron|IKBKAP_uc011lwc.1_Intron|IKBKAP_uc010mtq.2_Intron	NM_003640	NP_003631			inhibitor of kappa light polypeptide gene						immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	7																		---	---	---	---
ROD1	9991	broad.mit.edu	37	9	115013192	115013192	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:115013192delA	uc004bfw.2	-						ROD1_uc004bfv.2_Intron|ROD1_uc004bfx.2_Intron|ROD1_uc011lwu.1_Intron|ROD1_uc004bfy.2_Intron|ROD1_uc004bfz.2_Intron	NM_005156	NP_005147			ROD1 regulator of differentiation 1 isoform 1						anatomical structure morphogenesis|mRNA processing	nucleus	nucleotide binding|RNA binding			skin(1)	1																		---	---	---	---
ZNF618	114991	broad.mit.edu	37	9	116812587	116812587	+	3'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:116812587delT	uc004bid.2	+	15					ZNF618_uc004bic.2_3'UTR|ZNF618_uc011lxi.1_3'UTR|ZNF618_uc011lxj.1_3'UTR|ZNF618_uc010mvb.2_3'UTR	NM_133374	NP_588615			zinc finger protein 618						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	9	121526363	121526363	+	IGR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:121526363delA								None (None upstream) : DBC1 (402545 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	9	123007117	123007117	+	IGR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:123007117delA								DBC1 (875378 upstream) : MIR147 (140 downstream)																																			---	---	---	---
MEGF9	1955	broad.mit.edu	37	9	123421596	123421596	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:123421596delT	uc004bkj.1	-						MEGF9_uc011lyb.1_Intron|MEGF9_uc004bkk.3_3'UTR	NM_001080497	NP_001073966			multiple EGF-like-domains 9							integral to membrane	calcium ion binding				0																		---	---	---	---
STOM	2040	broad.mit.edu	37	9	124111280	124111280	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:124111280delA	uc004blh.2	-						STOM_uc011lyk.1_Intron|STOM_uc004bli.2_Intron	NM_004099	NP_004090			stomatin isoform a						protein homooligomerization	cytoskeleton|integral to plasma membrane|melanosome|membrane raft	protein binding				0				OV - Ovarian serous cystadenocarcinoma(323;0.00107)|GBM - Glioblastoma multiforme(294;0.0137)														---	---	---	---
Unknown	0	broad.mit.edu	37	9	124281959	124281959	+	IGR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:124281959delA								GGTA1 (19653 upstream) : DAB2IP (47440 downstream)																																			---	---	---	---
RABGAP1	23637	broad.mit.edu	37	9	125759385	125759386	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:125759385_125759386insT	uc011lzh.1	+						RABGAP1_uc004bnl.3_Intron	NM_012197	NP_036329			RAB GTPase activating protein 1						cell cycle	centrosome|cytosol|microtubule associated complex	Rab GTPase activator activity|tubulin binding			ovary(3)|kidney(2)	5																		---	---	---	---
LHX2	9355	broad.mit.edu	37	9	126776447	126776447	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:126776447delC	uc004boe.1	+						LHX2_uc010mwi.1_Intron	NM_004789	NP_004780			LIM homeobox protein 2							nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding				0																		---	---	---	---
GOLGA1	2800	broad.mit.edu	37	9	127689148	127689148	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:127689148delA	uc004bpc.2	-						GOLGA1_uc010mws.2_Intron|GOLGA1_uc010mwt.1_Intron	NM_002077	NP_002068			golgin 97							Golgi cisterna membrane				ovary(1)	1																		---	---	---	---
GARNL3	84253	broad.mit.edu	37	9	130076035	130076035	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:130076035delA	uc011mae.1	+						GARNL3_uc011mad.1_Intron	NM_032293	NP_115669			GTPase activating Rap/RanGAP domain-like 3						regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			ovary(1)|central_nervous_system(1)|skin(1)	3																		---	---	---	---
SPTAN1	6709	broad.mit.edu	37	9	131353673	131353674	+	Intron	DEL	GT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131353673_131353674delGT	uc004bvl.3	+						SPTAN1_uc011mbg.1_Intron|SPTAN1_uc011mbh.1_Intron|SPTAN1_uc004bvm.3_Intron|SPTAN1_uc004bvn.3_Intron	NM_003127	NP_003118			spectrin, alpha, non-erythrocytic 1						actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10																		---	---	---	---
PHYHD1	254295	broad.mit.edu	37	9	131689650	131689650	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131689650delT	uc004bwo.2	+						PHYHD1_uc004bwn.2_Intron|PHYHD1_uc004bwm.2_Intron|PHYHD1_uc004bwp.2_Intron	NM_001100876	NP_001094346			phytanoyl-CoA dioxygenase domain containing 1								metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0																OREG0019526	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
FAM73B	84895	broad.mit.edu	37	9	131825435	131825435	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131825435delC	uc004bxa.2	+						FAM73B_uc004bwy.2_Intron|FAM73B_uc004bwz.2_Intron|FAM73B_uc011mbn.1_Intron	NM_032809	NP_116198			hypothetical protein LOC84895							integral to membrane				skin(1)	1																		---	---	---	---
USP20	10868	broad.mit.edu	37	9	132623004	132623004	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:132623004delA	uc004bys.2	+						USP20_uc004byr.2_Intron|USP20_uc004byt.1_Intron	NM_001110303	NP_001103773			ubiquitin specific protease 20						endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|ubiquitin thiolesterase activity|zinc ion binding			lung(1)|breast(1)	2		Ovarian(14;0.00556)																---	---	---	---
FNBP1	23048	broad.mit.edu	37	9	132678318	132678318	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:132678318delA	uc004byw.1	-						FNBP1_uc011mbv.1_Intron|FNBP1_uc011mbw.1_Intron|FNBP1_uc004bza.2_Intron|FNBP1_uc004byz.1_Intron|FNBP1_uc011mbu.1_Intron|FNBP1_uc004byx.1_Intron|FNBP1_uc004byy.1_Intron	NM_015033	NP_055848			formin binding protein 1						endocytosis	cell cortex|cytoplasmic membrane-bounded vesicle|cytoskeleton|lysosome|plasma membrane	identical protein binding|lipid binding				0		Ovarian(14;0.000536)		GBM - Glioblastoma multiforme(294;0.0378)				T	MLL	AML								---	---	---	---
EXOSC2	23404	broad.mit.edu	37	9	133576061	133576062	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:133576061_133576062insA	uc004bzu.2	+						EXOSC2_uc011mbz.1_Intron|EXOSC2_uc011mca.1_Intron	NM_014285	NP_055100			exosome component 2						exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|positive regulation of cell growth|rRNA processing	cytosol|exosome (RNase complex)|nucleolus	3'-5'-exoribonuclease activity|7S RNA binding|protein binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0508)|all_hematologic(13;0.0588)		OV - Ovarian serous cystadenocarcinoma(145;0.000324)												OREG0019548	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
MED27	9442	broad.mit.edu	37	9	134889604	134889604	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:134889604delA	uc004cbe.1	-						MED27_uc004cbf.1_Intron|MED27_uc011mco.1_Intron|MED27_uc004cbg.3_Intron	NM_004269	NP_004260			mediator complex subunit 27						regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleolus|transcription factor complex	protein binding|transcription coactivator activity			skin(1)	1		Myeloproliferative disorder(178;0.206)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000193)														---	---	---	---
COL5A1	1289	broad.mit.edu	37	9	137600270	137600270	+	Intron	DEL	T	-	-	rs4841925	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:137600270delT	uc004cfe.2	+							NM_000093	NP_000084			alpha 1 type V collagen preproprotein						axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)														---	---	---	---
KCNT1	57582	broad.mit.edu	37	9	138671198	138671198	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:138671198delC	uc011mdq.1	+						KCNT1_uc011mdr.1_Intron|KCNT1_uc010nbf.2_Intron|KCNT1_uc004cgo.1_Intron	NM_020822	NP_065873			potassium channel, subfamily T, member 1							membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)														---	---	---	---
NOTCH1	4851	broad.mit.edu	37	9	139397578	139397578	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139397578delG	uc004chz.2	-						NOTCH1_uc004cia.1_Frame_Shift_Del_p.P971fs	NM_017617	NP_060087			notch1 preproprotein						aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)				T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			---	---	---	---
FBXW5	54461	broad.mit.edu	37	9	139837701	139837702	+	Intron	DEL	CC	-	-	rs11339872		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139837701_139837702delCC	uc004cjx.2	-						FBXW5_uc010nbx.2_5'Flank|FBXW5_uc004cjy.2_Intron|FBXW5_uc004cjz.2_Intron|C8G_uc004cka.2_5'Flank	NM_018998	NP_061871			F-box and WD repeat domain containing 5								catalytic activity|protein binding				0	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;7.8e-06)|Epithelial(140;0.000106)														---	---	---	---
SLC34A3	142680	broad.mit.edu	37	9	140127408	140127408	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:140127408delG	uc004cmf.1	+						SLC34A3_uc004cmc.1_Intron|SLC34A3_uc004cmd.1_Intron|SLC34A3_uc011met.1_Intron	NM_080877	NP_543153			solute carrier family 34 (sodium phosphate),						cellular phosphate ion homeostasis	apical plasma membrane|integral to membrane	sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)														---	---	---	---
PNPLA7	375775	broad.mit.edu	37	9	140396079	140396079	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:140396079delC	uc004cnf.2	-						C9orf167_uc011mew.1_Intron|PNPLA7_uc011mfa.1_Intron|PNPLA7_uc010ncj.1_Intron	NM_152286	NP_689499			patatin-like phospholipase domain containing 7						lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			skin(1)	1	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)														---	---	---	---
WDR85	92715	broad.mit.edu	37	9	140468517	140468517	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:140468517delA	uc004cnk.1	-						WDR85_uc004cnl.1_Intron|WDR85_uc004cnm.1_Intron|WDR85_uc004cnn.1_Intron	NM_138778	NP_620133			WD repeat domain 85						peptidyl-diphthamide biosynthetic process from peptidyl-histidine						0	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.00029)|Epithelial(140;0.000509)														---	---	---	---
WDR37	22884	broad.mit.edu	37	10	1142283	1142283	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:1142283delC	uc001igf.1	+						WDR37_uc001ige.2_3'UTR|WDR37_uc009xhm.1_Intron|WDR37_uc009xhn.1_Intron|WDR37_uc001igg.1_Intron	NM_014023	NP_054742			WD repeat domain 37												0		all_epithelial(10;0.0449)|Colorectal(49;0.142)		Epithelial(11;0.134)														---	---	---	---
AKR1C2	1646	broad.mit.edu	37	10	5045397	5045398	+	Intron	DEL	TT	-	-	rs71929051		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:5045397_5045398delTT	uc010qan.1	-						AKR1E2_uc001ihl.1_Intron|AKR1C3_uc001ihr.2_Intron|AKR1C2_uc009xhy.2_Intron|AKR1C2_uc001ihs.2_Intron|AKR1C2_uc001iht.2_Intron|AKR1C2_uc010qao.1_Intron	NM_205845	NP_995317			aldo-keto reductase family 1, member C2						digestion|prostaglandin metabolic process|steroid metabolic process	cytoplasm	androsterone dehydrogenase (A-specific) activity|bile acid binding|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity				0					NADH(DB00157)|Ursodeoxycholic acid(DB01586)													---	---	---	---
FBXO18	84893	broad.mit.edu	37	10	5967638	5967638	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:5967638delA	uc001iis.2	+						FBXO18_uc001iir.2_Intron|FBXO18_uc009xig.2_Intron|FBXO18_uc001iit.2_Intron	NM_178150	NP_835363			F-box only protein, helicase, 18 isoform 2						DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(2)|skin(1)	3																		---	---	---	---
KIN	22944	broad.mit.edu	37	10	7816627	7816628	+	Intron	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:7816627_7816628delAA	uc001ijt.2	-						KIN_uc010qaz.1_Intron|KIN_uc009xip.2_Intron|KIN_uc010qba.1_Intron	NM_012311	NP_036443			HsKin17 protein						DNA recombination|DNA repair|DNA replication|interspecies interaction between organisms|mRNA processing	cytoplasm|nuclear matrix	double-stranded DNA binding|RNA binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3																		---	---	---	---
UPF2	26019	broad.mit.edu	37	10	12046454	12046454	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:12046454delT	uc001ila.2	-						UPF2_uc001ilb.2_Intron|UPF2_uc001ilc.2_Intron|UPF2_uc009xiz.1_Intron	NM_080599	NP_542166			UPF2 regulator of nonsense transcripts homolog						mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			central_nervous_system(2)|ovary(1)	3		Renal(717;0.228)																---	---	---	---
OPTN	10133	broad.mit.edu	37	10	13150911	13150912	+	Intron	DEL	CA	-	-	rs71386156	byFrequency	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:13150911_13150912delCA	uc001ilu.1	+						OPTN_uc001ilv.1_Intron|OPTN_uc001ilw.1_Intron|OPTN_uc001ilx.1_Intron|OPTN_uc001ily.1_Intron|OPTN_uc010qbr.1_Intron|OPTN_uc001ilz.1_Intron	NM_001008213	NP_001008214			optineurin						cell death|Golgi ribbon formation|Golgi to plasma membrane protein transport|protein targeting to Golgi|signal transduction	perinuclear region of cytoplasm|trans-Golgi network	protein C-terminus binding			ovary(2)	2																		---	---	---	---
OPTN	10133	broad.mit.edu	37	10	13151192	13151192	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:13151192delC	uc001ilu.1	+	4	508	c.70delC	c.(70-72)CCCfs	p.P24fs	OPTN_uc001ilv.1_Frame_Shift_Del_p.P24fs|OPTN_uc001ilw.1_Frame_Shift_Del_p.P24fs|OPTN_uc001ilx.1_Frame_Shift_Del_p.P24fs|OPTN_uc001ily.1_Frame_Shift_Del_p.P24fs|OPTN_uc010qbr.1_5'UTR|OPTN_uc001ilz.1_Frame_Shift_Del_p.P24fs	NM_001008213	NP_001008214	Q96CV9	OPTN_HUMAN	optineurin	24					cell death|Golgi ribbon formation|Golgi to plasma membrane protein transport|protein targeting to Golgi|signal transduction	perinuclear region of cytoplasm|trans-Golgi network	protein C-terminus binding			ovary(2)	2																		---	---	---	---
FRMD4A	55691	broad.mit.edu	37	10	13696452	13696452	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:13696452delG	uc001ims.2	-	23	3366	c.3014delC	c.(3013-3015)CCAfs	p.P1005fs	PRPF18_uc001imq.2_Intron|FRMD4A_uc009xjf.1_Frame_Shift_Del_p.P1005fs	NM_018027	NP_060497	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	1005	Ser-rich.					cytoplasm|cytoskeleton	binding			ovary(1)|skin(1)|pancreas(1)	3																		---	---	---	---
FRMD4A	55691	broad.mit.edu	37	10	13804730	13804730	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:13804730delT	uc001ims.2	-						FRMD4A_uc009xjf.1_Intron|FRMD4A_uc001imt.1_Intron|FRMD4A_uc001imu.1_Intron	NM_018027	NP_060497			FERM domain containing 4A							cytoplasm|cytoskeleton	binding			ovary(1)|skin(1)|pancreas(1)	3																		---	---	---	---
HSPA14	51182	broad.mit.edu	37	10	14908967	14908968	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:14908967_14908968insT	uc001inf.2	+							NM_016299	NP_057383			heat shock 70kDa protein 14 isoform 1						'de novo' cotranslational protein folding	cytosol	ATP binding|protein binding			ovary(2)|breast(2)|lung(1)	5																		---	---	---	---
RPP38	10557	broad.mit.edu	37	10	15145272	15145273	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:15145272_15145273insT	uc001iny.3	+						RPP38_uc009xjm.2_Intron|RPP38_uc001inx.3_Intron	NM_183005	NP_892117			ribonuclease P/MRP 38 subunit						tRNA processing	nucleolar ribonuclease P complex	protein binding|ribonuclease P activity			ovary(1)	1																		---	---	---	---
FAM171A1	221061	broad.mit.edu	37	10	15257899	15257899	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:15257899delA	uc001iob.2	-							NM_001010924	NP_001010924			hypothetical protein LOC221061 precursor							integral to membrane				ovary(2)|breast(1)|skin(1)	4																		---	---	---	---
FAM188A	80013	broad.mit.edu	37	10	15831328	15831328	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:15831328delA	uc001iod.1	-						FAM188A_uc001ioe.1_Intron|FAM188A_uc001iof.1_Intron	NM_024948	NP_079224			chromosome 10 open reading frame 97						apoptosis	nucleus	calcium ion binding			ovary(1)	1																		---	---	---	---
CUBN	8029	broad.mit.edu	37	10	16867091	16867091	+	Intron	DEL	A	-	-	rs76258142		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:16867091delA	uc001ioo.2	-							NM_001081	NP_001072			cubilin precursor						cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)													---	---	---	---
CUBN	8029	broad.mit.edu	37	10	16961935	16961935	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:16961935delA	uc001ioo.2	-							NM_001081	NP_001072			cubilin precursor						cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)													---	---	---	---
VIM	7431	broad.mit.edu	37	10	17276623	17276623	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:17276623delT	uc001iou.2	+						VIM_uc001iov.1_Intron|VIM_uc001iow.1_Intron|VIM_uc001iox.1_Intron|VIM_uc001ioy.1_Intron|VIM_uc001ioz.1_Intron|VIM_uc001ipb.1_Intron|VIM_uc009xjv.1_Intron|VIM_uc001ipc.1_Intron	NM_003380	NP_003371			vimentin						cellular component disassembly involved in apoptosis|cellular component movement|interspecies interaction between organisms|muscle filament sliding	cytosol|intermediate filament	protein C-terminus binding|structural constituent of cytoskeleton			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4																		---	---	---	---
STAM	8027	broad.mit.edu	37	10	17726665	17726665	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:17726665delT	uc001ipj.1	+						STAM_uc010qcf.1_Intron	NM_003473	NP_003464			signal transducing adaptor molecule 1						cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	SH3/SH2 adaptor activity			large_intestine(1)|ovary(1)	2																		---	---	---	---
MRC1	4360	broad.mit.edu	37	10	17865318	17865318	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:17865318delA	uc001ipk.2	+	2	410	c.307delA	c.(307-309)AAAfs	p.K103fs		NM_002438	NP_002429	P22897	MRC1_HUMAN	mannose receptor C type 1 precursor	103	Extracellular (Potential).|Ricin B-type lectin.				receptor-mediated endocytosis	endosome membrane|integral to plasma membrane	mannose binding|receptor activity				0																		---	---	---	---
PLXDC2	84898	broad.mit.edu	37	10	20465916	20465916	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:20465916delT	uc001iqg.1	+						PLXDC2_uc001iqh.1_Intron|PLXDC2_uc009xkc.1_Intron	NM_032812	NP_116201			plexin domain containing 2 precursor							integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4																		---	---	---	---
YME1L1	10730	broad.mit.edu	37	10	27409239	27409239	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:27409239delA	uc001iti.2	-						YME1L1_uc001itj.2_Intron|YME1L1_uc010qdl.1_Intron|YME1L1_uc009xkv.2_Intron	NM_139312	NP_647473			YME1-like 1 isoform 1						protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			ovary(1)	1																		---	---	---	---
MASTL	84930	broad.mit.edu	37	10	27470152	27470152	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:27470152delA	uc001itm.2	+						MASTL_uc001itl.2_Intron|MASTL_uc009xkw.1_Intron|MASTL_uc009xkx.1_Intron	NM_032844	NP_116233			microtubule associated serine/threonine						cell division|G2/M transition of mitotic cell cycle|mitosis|negative regulation of protein phosphatase type 2A activity|regulation of cell cycle|response to DNA damage stimulus	centrosome|cleavage furrow|nucleus	ATP binding|protein phosphatase 2A binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3																		---	---	---	---
RAB18	22931	broad.mit.edu	37	10	27822484	27822484	+	Intron	DEL	A	-	-	rs5784015		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:27822484delA	uc001itv.2	+						RAB18_uc001itw.2_Intron|RAB18_uc010qdq.1_Intron|RAB18_uc010qdr.1_Intron	NM_021252	NP_067075			RAB18, member RAS oncogene family						endocytosis|protein transport|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction	intracellular|plasma membrane	ATP binding|GTP binding|GTPase activity|transcription factor binding				0																		---	---	---	---
SVIL	6840	broad.mit.edu	37	10	29760116	29760116	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:29760116delC	uc001iut.1	-	31	6339	c.5586delG	c.(5584-5586)GGGfs	p.G1862fs	LOC387647_uc001iup.2_Intron|LOC387647_uc001iuq.1_Intron|SVIL_uc010qdw.1_Frame_Shift_Del_p.G776fs|SVIL_uc001iuu.1_Frame_Shift_Del_p.G1436fs	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	1862	Gelsolin-like 3.				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)																---	---	---	---
NRP1	8829	broad.mit.edu	37	10	33510802	33510802	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:33510802delA	uc001iwx.3	-						NRP1_uc001iwv.3_Intron|NRP1_uc009xlz.2_Intron|NRP1_uc001iww.3_Intron|NRP1_uc001iwy.3_Intron|NRP1_uc001iwz.2_Intron|NRP1_uc001ixa.2_Intron|NRP1_uc001ixb.1_Intron|NRP1_uc001ixc.1_Intron	NM_003873	NP_003864			neuropilin 1 isoform a						axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4					Palifermin(DB00039)|Pegaptanib(DB04895)													---	---	---	---
PARD3	56288	broad.mit.edu	37	10	34635479	34635479	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:34635479delA	uc010qej.1	-						PARD3_uc010qek.1_Intron|PARD3_uc010qel.1_Intron|PARD3_uc010qem.1_Intron|PARD3_uc010qen.1_Intron|PARD3_uc010qeo.1_Intron|PARD3_uc010qep.1_Intron|PARD3_uc010qeq.1_Intron|PARD3_uc001ixo.1_Intron|PARD3_uc001ixp.1_Intron|PARD3_uc001ixq.1_Intron|PARD3_uc001ixr.1_Intron|PARD3_uc001ixt.1_Intron|PARD3_uc001ixu.1_Intron|PARD3_uc001ixs.1_Intron	NM_019619	NP_062565			partitioning-defective protein 3 homolog						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)																---	---	---	---
CUL2	8453	broad.mit.edu	37	10	35302598	35302598	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:35302598delA	uc001ixv.2	-						CUL2_uc009xma.2_Intron|CUL2_uc010qer.1_Intron|CUL2_uc001ixw.2_Intron	NM_003591	NP_003582			cullin 2						cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex	ubiquitin protein ligase binding			ovary(3)	3																		---	---	---	---
Unknown	0	broad.mit.edu	37	10	38184684	38184684	+	IGR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:38184684delA								ZNF248 (37672 upstream) : ZNF25 (54111 downstream)																																			---	---	---	---
BMS1	9790	broad.mit.edu	37	10	43312697	43312697	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:43312697delA	uc001jaj.2	+							NM_014753	NP_055568			BMS1-like, ribosome assembly protein						ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			ovary(2)|upper_aerodigestive_tract(1)	3																		---	---	---	---
C10orf25	220979	broad.mit.edu	37	10	45496243	45496243	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:45496243delG	uc001jbv.1	-	1	94	c.65delC	c.(64-66)CCAfs	p.P22fs	C10orf25_uc010qff.1_RNA|ZNF22_uc001jbw.2_5'Flank	NM_001039380	NP_001034469	Q5T742	CJ025_HUMAN	hypothetical protein LOC220979 precursor	22						extracellular region					0																		---	---	---	---
FAM21C	253725	broad.mit.edu	37	10	46249748	46249748	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:46249748delA	uc001jcu.2	+						FAM21C_uc001jcs.1_Intron|FAM21C_uc001jct.2_Intron|FAM21C_uc010qfi.1_Intron|FAM21C_uc010qfj.1_Intron|FAM21C_uc010qfk.1_5'Flank	NM_015262	NP_056077			hypothetical protein LOC253725											ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	10	47965440	47965441	+	IGR	INS	-	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:47965440_47965441insC								FAM21B (16024 upstream) : ZNF488 (389648 downstream)																																			---	---	---	---
PARG	8505	broad.mit.edu	37	10	51580462	51580462	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:51580462delC	uc001jih.2	-						uc010qha.1_Intron|uc001jin.2_Intron|uc010qhb.1_Intron|uc010qhc.1_Intron|NCOA4_uc009xon.2_Intron|NCOA4_uc010qhd.1_Intron|NCOA4_uc001jis.3_Intron|NCOA4_uc010qhe.1_Intron|NCOA4_uc010qhf.1_Intron|NCOA4_uc001jit.2_Intron|NCOA4_uc009xoo.2_Intron	NM_003631	NP_003622			poly (ADP-ribose) glycohydrolase						carbohydrate metabolic process	nucleus	poly(ADP-ribose) glycohydrolase activity			ovary(2)	2				Epithelial(53;0.213)														---	---	---	---
PARG	8505	broad.mit.edu	37	10	51581255	51581255	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:51581255delT	uc001jih.2	-						uc010qha.1_Intron|uc001jin.2_Intron|uc010qhb.1_Intron|uc010qhc.1_Intron|NCOA4_uc009xon.2_Intron|NCOA4_uc010qhd.1_Intron|NCOA4_uc001jis.3_Intron|NCOA4_uc010qhe.1_Intron|NCOA4_uc010qhf.1_Intron|NCOA4_uc001jit.2_Intron|NCOA4_uc009xoo.2_Intron	NM_003631	NP_003622			poly (ADP-ribose) glycohydrolase						carbohydrate metabolic process	nucleus	poly(ADP-ribose) glycohydrolase activity			ovary(2)	2				Epithelial(53;0.213)														---	---	---	---
Unknown	0	broad.mit.edu	37	10	52024834	52024834	+	IGR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:52024834delA								ASAH2 (16464 upstream) : SGMS1 (40512 downstream)																																			---	---	---	---
PRKG1	5592	broad.mit.edu	37	10	54053522	54053522	+	Intron	DEL	A	-	-	rs68171603		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:54053522delA	uc001jjm.2	+						PRKG1_uc001jjo.2_Intron|PRKG1_uc009xow.1_Intron|uc001jjq.1_Intron	NM_001098512	NP_001091982			protein kinase, cGMP-dependent, type I isoform						actin cytoskeleton organization|platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			lung(2)|stomach(1)|ovary(1)|central_nervous_system(1)|skin(1)	6		all_cancers(4;2.13e-08)|all_epithelial(4;2.44e-08)|all_lung(4;0.000173)		all cancers(4;1.18e-05)|GBM - Glioblastoma multiforme(4;0.000359)|Epithelial(53;0.00532)|Lung(62;0.0606)														---	---	---	---
Unknown	0	broad.mit.edu	37	10	54172961	54172962	+	IGR	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:54172961_54172962insA								DKK1 (95545 upstream) : MBL2 (352179 downstream)																																			---	---	---	---
IPMK	253430	broad.mit.edu	37	10	59959206	59959206	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:59959206delA	uc001jkb.2	-							NM_152230	NP_689416			inositol polyphosphate multikinase							nucleus	ATP binding|inositol trisphosphate 6-kinase activity			ovary(1)	1																		---	---	---	---
ANK3	288	broad.mit.edu	37	10	61835708	61835708	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:61835708delG	uc001jky.2	-	37	5123	c.4931delC	c.(4930-4932)CCTfs	p.P1644fs	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	1644	Ser-rich.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19																		---	---	---	---
ANK3	288	broad.mit.edu	37	10	61848192	61848192	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:61848192delT	uc001jky.2	-						ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jla.1_Intron|ANK3_uc001jlb.1_Intron	NM_020987	NP_066267			ankyrin 3 isoform 1						establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19																		---	---	---	---
ANK3	288	broad.mit.edu	37	10	61893945	61893945	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:61893945delT	uc001jky.2	-						ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jla.1_Intron|ANK3_uc001jlb.1_Intron	NM_020987	NP_066267			ankyrin 3 isoform 1						establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19																		---	---	---	---
LRRTM3	347731	broad.mit.edu	37	10	68688300	68688301	+	Intron	INS	-	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:68688300_68688301insC	uc001jmz.1	+						CTNNA3_uc009xpn.1_Intron|CTNNA3_uc001jmw.2_Intron|CTNNA3_uc001jmx.3_Intron|CTNNA3_uc009xpo.1_Intron|LRRTM3_uc001jmy.2_3'UTR	NM_178011	NP_821079			leucine rich repeat transmembrane neuronal 3							integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3																		---	---	---	---
SIRT1	23411	broad.mit.edu	37	10	69668900	69668900	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:69668900delT	uc001jnd.2	+						SIRT1_uc010qis.1_Intron|SIRT1_uc009xpp.2_Intron|SIRT1_uc001jne.2_Intron	NM_012238	NP_036370			sirtuin 1 isoform a						apoptosis|cell aging|cellular response to hydrogen peroxide|cellular response to starvation|chromatin silencing at rDNA|DNA repair|DNA replication|establishment of chromatin silencing|histone H3 deacetylation|interspecies interaction between organisms|maintenance of chromatin silencing|muscle organ development|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of fat cell differentiation|negative regulation of helicase activity|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|peptidyl-lysine acetylation|peptidyl-lysine deacetylation|positive regulation of anti-apoptosis|positive regulation of chromatin silencing|positive regulation of DNA repair|regulation of apoptosis|regulation of cell proliferation|regulation of endodeoxyribonuclease activity|regulation of protein import into nucleus, translocation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|rRNA processing|transcription, DNA-dependent|triglyceride mobilization|white fat cell differentiation	chromatin silencing complex|cytoplasm|nuclear euchromatin|nuclear heterochromatin|nuclear inner membrane|nucleolus|PML body|rDNA heterochromatin	bHLH transcription factor binding|histone binding|HLH domain binding|identical protein binding|mitogen-activated protein kinase binding|NAD+ binding|NAD-dependent histone deacetylase activity (H3-K9 specific)|p53 binding|protein C-terminus binding|transcription corepressor activity|zinc ion binding				0																		---	---	---	---
RUFY2	55680	broad.mit.edu	37	10	70136913	70136913	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:70136913delT	uc001job.2	-						RUFY2_uc001jnz.1_Intron|RUFY2_uc001joa.2_5'UTR	NM_017987	NP_060457			RUN and FYVE domain-containing 2 isoform a							nucleus	metal ion binding			ovary(1)	1																		---	---	---	---
DNA2	1763	broad.mit.edu	37	10	70228199	70228199	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:70228199delA	uc001jof.2	-						DNA2_uc001jog.1_Intron|DNA2_uc001joh.1_Intron	NM_001080449	NP_001073918			DNA replication helicase 2 homolog						base-excision repair|DNA replication, removal of RNA primer|mitochondrial DNA repair|mitochondrial DNA replication|positive regulation of DNA replication|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	mitochondrial nucleoid|nucleoplasm	5'-flap endonuclease activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|site-specific endodeoxyribonuclease activity, specific for altered base				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	10	70304123	70304124	+	IGR	DEL	TT	-	-	rs71716010		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:70304123_70304124delTT								SLC25A16 (16539 upstream) : TET1 (15993 downstream)																																			---	---	---	---
TET1	80312	broad.mit.edu	37	10	70392271	70392271	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:70392271delT	uc001jok.3	+							NM_030625	NP_085128			CXXC finger 6						DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9																		---	---	---	---
CCAR1	55749	broad.mit.edu	37	10	70507396	70507396	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:70507396delA	uc001joo.2	+						CCAR1_uc001jol.1_Intron|CCAR1_uc001jom.1_Intron|CCAR1_uc009xpx.1_Intron|CCAR1_uc001jon.1_Intron|CCAR1_uc010qiz.1_Intron|CCAR1_uc010qja.1_Intron|CCAR1_uc010qjb.1_Intron	NM_018237	NP_060707			cell-cycle and apoptosis regulatory protein 1						apoptosis|cell cycle|nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm|perinuclear region of cytoplasm	calcium ion binding|nucleic acid binding|protein binding			ovary(6)|large_intestine(1)	7																		---	---	---	---
DDX21	9188	broad.mit.edu	37	10	70731843	70731844	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:70731843_70731844insT	uc001jov.1	+						DDX21_uc001jow.1_Intron	NM_004728	NP_004719			DEAD (Asp-Glu-Ala-Asp) box polypeptide 21							nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)	3																		---	---	---	---
PRF1	5551	broad.mit.edu	37	10	72360093	72360093	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:72360093delC	uc009xqg.2	-						PRF1_uc001jrf.3_Intron	NM_001083116	NP_001076585			perforin 1 precursor						apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3								M			various leukaemia|lymphoma	Type 2 familial hemophagocytic lymphohistiocytosis		Familial_Hemophagocytic_Lymphohistiocytosis				---	---	---	---
SGPL1	8879	broad.mit.edu	37	10	72619117	72619117	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:72619117delT	uc001jrm.2	+							NM_003901	NP_003892			sphingosine-1-phosphate lyase 1						apoptosis|carboxylic acid metabolic process|ceramide metabolic process|sphingolipid catabolic process	integral to endoplasmic reticulum membrane	carboxy-lyase activity|pyridoxal phosphate binding|sphinganine-1-phosphate aldolase activity				0					Pyridoxal Phosphate(DB00114)													---	---	---	---
PCBD1	5092	broad.mit.edu	37	10	72644720	72644720	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:72644720delT	uc001jrn.1	-							NM_000281	NP_000272			pterin-4 alpha-carbinolamine						L-phenylalanine catabolic process|regulation of transcription, DNA-dependent|tetrahydrobiopterin biosynthetic process|transcription, DNA-dependent	cytosol|nucleus	4-alpha-hydroxytetrahydrobiopterin dehydratase activity|identical protein binding|transcription coactivator activity				0																		---	---	---	---
SLC29A3	55315	broad.mit.edu	37	10	73104126	73104126	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:73104126delT	uc001jrr.3	+						SLC29A3_uc001jrs.3_Intron|SLC29A3_uc010qjq.1_Intron|SLC29A3_uc001jrt.3_Intron|SLC29A3_uc001jru.3_Intron	NM_018344	NP_060814			solute carrier family 29 (nucleoside						nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|late endosome membrane|lysosomal membrane	nucleoside transmembrane transporter activity				0																		---	---	---	---
ASCC1	51008	broad.mit.edu	37	10	73887716	73887716	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:73887716delA	uc001jst.1	-						ASCC1_uc001jsr.1_Intron|ASCC1_uc001jss.1_Intron|ASCC1_uc001jsu.1_Intron|ASCC1_uc010qju.1_Intron					RecName: Full=Activating signal cointegrator 1 complex subunit 1; AltName: Full=ASC-1 complex subunit p50; AltName: Full=Trip4 complex subunit p50;						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	RNA binding				0																		---	---	---	---
CCDC109A	90550	broad.mit.edu	37	10	74628310	74628313	+	Intron	DEL	AAAA	-	-	rs78503891		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:74628310_74628313delAAAA	uc001jtc.2	+						CCDC109A_uc009xqp.1_Intron|CCDC109A_uc009xqq.1_Intron|CCDC109A_uc010qjy.1_Intron|CCDC109A_uc009xqr.2_Intron|CCDC109A_uc001jtd.2_Intron	NM_138357	NP_612366			coiled-coil domain containing 109A						elevation of mitochondrial calcium ion concentration|mitochondrial calcium ion transport|protein complex oligomerization	integral to membrane|mitochondrial inner membrane	protein binding				0	Prostate(51;0.0198)																	---	---	---	---
VCL	7414	broad.mit.edu	37	10	75860952	75860952	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:75860952delA	uc001jwd.2	+						VCL_uc009xrr.2_Intron|VCL_uc010qky.1_Intron|VCL_uc001jwe.2_Intron|VCL_uc010qkz.1_Intron	NM_014000	NP_054706			vinculin isoform meta-VCL						adherens junction assembly|apical junction assembly|cell-matrix adhesion|cellular component movement|epithelial cell-cell adhesion|lamellipodium assembly|morphogenesis of an epithelium|muscle contraction|negative regulation of cell migration|platelet activation|platelet degranulation|protein localization at cell surface	costamere|cytosol|extracellular region|focal adhesion	actin binding|alpha-catenin binding|beta-catenin binding|beta-dystroglycan binding|cadherin binding|structural molecule activity		VCL/ALK(4)	kidney(4)|ovary(1)|central_nervous_system(1)	6	Prostate(51;0.0112)																	---	---	---	---
SAMD8	142891	broad.mit.edu	37	10	76928537	76928537	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:76928537delA	uc001jwx.1	+						SAMD8_uc001jwy.1_Intron	NM_144660	NP_653261			sterile alpha motif domain containing 8						sphingomyelin biosynthetic process	integral to membrane					0	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)																	---	---	---	---
SFTPA1	653509	broad.mit.edu	37	10	81373244	81373245	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:81373244_81373245insT	uc001kap.2	+						SFTPA1_uc001kaq.2_Intron|SFTPA1_uc009xry.2_Intron|SFTPA1_uc001kar.2_Intron|SFTPA1_uc010qlt.1_Intron|SFTPA1_uc009xrz.2_Intron|SFTPA1_uc009xsa.2_Intron|SFTPA1_uc009xsf.2_5'Flank	NM_005411	NP_005402			surfactant protein A1 isoform 1						cell junction assembly|respiratory gaseous exchange	collagen|extracellular space	lipid transporter activity|sugar binding				0	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)															---	---	---	---
Unknown	0	broad.mit.edu	37	10	82057637	82057637	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:82057637delT								MAT1A (8203 upstream) : DYDC1 (38227 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	10	82095804	82095804	+	IGR	DEL	A	-	-	rs72815321	byFrequency;by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:82095804delA								MAT1A (46370 upstream) : DYDC1 (60 downstream)																																			---	---	---	---
GHITM	27069	broad.mit.edu	37	10	85903586	85903586	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:85903586delT	uc001kcs.1	+						GHITM_uc010qma.1_Intron|GHITM_uc010qmb.1_Intron	NM_014394	NP_055209			growth hormone inducible transmembrane protein						apoptosis	integral to membrane|mitochondrial inner membrane					0																		---	---	---	---
GLUD1	2746	broad.mit.edu	37	10	88820205	88820206	+	Intron	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:88820205_88820206delTT	uc001keh.2	-						GLUD1_uc001keg.2_Intron|GLUD1_uc010qmp.1_Intron	NM_005271	NP_005262			glutamate dehydrogenase 1 precursor						glutamate biosynthetic process|glutamate catabolic process|positive regulation of insulin secretion	mitochondrial matrix	ADP binding|ATP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|identical protein binding|leucine binding|NAD+ binding				0					L-Glutamic Acid(DB00142)|NADH(DB00157)													---	---	---	---
BTAF1	9044	broad.mit.edu	37	10	93713640	93713640	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:93713640delT	uc001khr.2	+						BTAF1_uc009xua.1_Intron|BTAF1_uc001khs.1_5'Flank	NM_003972	NP_003963			BTAF1 RNA polymerase II, B-TFIID transcription						negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)																---	---	---	---
IDE	3416	broad.mit.edu	37	10	94223288	94223288	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:94223288delA	uc001kia.2	-						IDE_uc010qnp.1_Intron|IDE_uc001khz.2_Intron	NM_004969	NP_004960			insulin-degrading enzyme isoform 1 precursor						beta-amyloid metabolic process|bradykinin catabolic process|interspecies interaction between organisms|sex differentiation	cell surface|extracellular space|soluble fraction	ATP binding|metalloendopeptidase activity|protein homodimerization activity|signal transducer activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3					Bacitracin(DB00626)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)													---	---	---	---
KIF11	3832	broad.mit.edu	37	10	94388745	94388746	+	Intron	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:94388745_94388746delTT	uc001kic.2	+						KIF11_uc010qnq.1_Intron	NM_004523	NP_004514			kinesin family member 11						blood coagulation|cell division|microtubule-based movement|spindle assembly involved in mitosis	chromatin remodeling complex|cytosol|kinesin complex|microtubule|spindle pole	ATP binding|microtubule motor activity|protein kinase binding			skin(1)	1																		---	---	---	---
EXOC6	54536	broad.mit.edu	37	10	94675708	94675709	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:94675708_94675709insT	uc001kig.2	+						EXOC6_uc010qnr.1_Intron|EXOC6_uc001kie.2_Intron|EXOC6_uc009xub.2_Intron|EXOC6_uc009xuc.2_Intron	NM_019053	NP_061926			SEC15-like 1 isoform a						protein transport|vesicle docking involved in exocytosis	exocyst				skin(1)	1		Colorectal(252;0.123)																---	---	---	---
MYOF	26509	broad.mit.edu	37	10	95095461	95095462	+	Intron	INS	-	TTTCC	TTTCC	rs148769270	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:95095461_95095462insTTTCC	uc001kin.2	-						MYOF_uc001kio.2_Intron|MYOF_uc009xue.2_Intron	NM_013451	NP_038479			myoferlin isoform a						blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4																		---	---	---	---
CEP55	55165	broad.mit.edu	37	10	95259630	95259630	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:95259630delA	uc009xug.2	+						CEP55_uc001kiq.3_Intron	NM_001127182	NP_001120654			centrosomal protein 55kDa						cell division|mitosis	centriole|cleavage furrow|midbody					0		Colorectal(252;0.207)																---	---	---	---
PLCE1	51196	broad.mit.edu	37	10	95792051	95792051	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:95792051delT	uc001kjk.2	+						PLCE1_uc010qnx.1_Intron	NM_016341	NP_057425			phospholipase C, epsilon 1 isoform 1						activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)																---	---	---	---
HELLS	3070	broad.mit.edu	37	10	96313731	96313731	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:96313731delT	uc001kjt.2	+						HELLS_uc001kjs.2_Intron|HELLS_uc009xul.2_Intron|HELLS_uc009xum.2_Intron|HELLS_uc009xun.2_Intron|HELLS_uc009xuo.2_Intron|HELLS_uc001kju.2_Intron|HELLS_uc009xup.2_Intron|HELLS_uc009xuq.2_Intron|HELLS_uc009xur.2_Intron	NM_018063	NP_060533			helicase, lymphoid-specific						cell division|centromeric heterochromatin formation|lymphocyte proliferation|maintenance of DNA methylation|methylation-dependent chromatin silencing|mitosis|transcription, DNA-dependent	centromeric heterochromatin|nucleus	ATP binding|DNA binding|helicase activity			ovary(1)|kidney(1)	2		Colorectal(252;0.0429)		all cancers(201;2.13e-05)														---	---	---	---
HELLS	3070	broad.mit.edu	37	10	96322556	96322556	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:96322556delT	uc001kjt.2	+						HELLS_uc001kjs.2_Intron|HELLS_uc009xul.2_Intron|HELLS_uc009xum.2_Intron|HELLS_uc009xun.2_Intron|HELLS_uc009xuo.2_Intron|HELLS_uc001kju.2_Intron|HELLS_uc009xup.2_Intron|HELLS_uc009xuq.2_Intron|HELLS_uc009xur.2_Intron	NM_018063	NP_060533			helicase, lymphoid-specific						cell division|centromeric heterochromatin formation|lymphocyte proliferation|maintenance of DNA methylation|methylation-dependent chromatin silencing|mitosis|transcription, DNA-dependent	centromeric heterochromatin|nucleus	ATP binding|DNA binding|helicase activity			ovary(1)|kidney(1)	2		Colorectal(252;0.0429)		all cancers(201;2.13e-05)														---	---	---	---
HELLS	3070	broad.mit.edu	37	10	96347838	96347838	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:96347838delA	uc001kjt.2	+						HELLS_uc001kjs.2_Intron|HELLS_uc009xul.2_Intron|HELLS_uc009xum.2_Intron|HELLS_uc009xun.2_Intron|HELLS_uc009xuo.2_Intron|HELLS_uc001kju.2_Intron|HELLS_uc009xup.2_Intron|HELLS_uc009xuq.2_Intron|HELLS_uc009xur.2_Intron	NM_018063	NP_060533			helicase, lymphoid-specific						cell division|centromeric heterochromatin formation|lymphocyte proliferation|maintenance of DNA methylation|methylation-dependent chromatin silencing|mitosis|transcription, DNA-dependent	centromeric heterochromatin|nucleus	ATP binding|DNA binding|helicase activity			ovary(1)|kidney(1)	2		Colorectal(252;0.0429)		all cancers(201;2.13e-05)														---	---	---	---
DNTT	1791	broad.mit.edu	37	10	98082516	98082516	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:98082516delT	uc001kmf.2	+						DNTT_uc001kmg.2_Intron	NM_004088	NP_004079			terminal deoxynucleotidyltransferase isoform 1						DNA modification	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			ovary(1)	1		Colorectal(252;0.0815)|all_hematologic(284;0.224)		Epithelial(162;7.97e-08)|all cancers(201;1.89e-06)														---	---	---	---
SLIT1	6585	broad.mit.edu	37	10	98781316	98781320	+	Intron	DEL	TTTTT	-	-	rs11303965		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:98781316_98781320delTTTTT	uc001kmw.2	-							NM_003061	NP_003052			slit homolog 1 precursor						axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			ovary(4)	4		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)														---	---	---	---
HPSE2	60495	broad.mit.edu	37	10	100995724	100995727	+	5'Flank	DEL	CTCG	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:100995724_100995727delCTCG	uc001kpn.1	-						HPSE2_uc009xwc.1_5'Flank|HPSE2_uc001kpo.1_5'Flank|HPSE2_uc009xwd.1_5'Flank	NM_021828	NP_068600			heparanase 2						carbohydrate metabolic process	intracellular|membrane	cation binding|heparanase activity			ovary(1)	1				Epithelial(162;1.8e-09)|all cancers(201;4.72e-07)														---	---	---	---
ENTPD7	57089	broad.mit.edu	37	10	101439083	101439085	+	In_Frame_Del	DEL	TTG	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:101439083_101439085delTTG	uc001kqa.3	+	4	435_437	c.257_259delTTG	c.(256-261)CTTGTT>CTT	p.V88del	ENTPD7_uc009xwl.2_In_Frame_Del_p.V90del	NM_020354	NP_065087	Q9NQZ7	ENTP7_HUMAN	ectonucleoside triphosphate diphosphohydrolase	88	Vesicular (Potential).					cytoplasmic vesicle membrane|integral to membrane	hydrolase activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;4.72e-10)|all cancers(201;3.75e-08)														---	---	---	---
FAM178A	55719	broad.mit.edu	37	10	102697366	102697366	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:102697366delT	uc001krt.3	+						FAM178A_uc001krs.2_Intron	NM_018121	NP_060591			hypothetical protein LOC55719 isoform 1												0																		---	---	---	---
FGF8	2253	broad.mit.edu	37	10	103530412	103530412	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:103530412delC	uc001ktp.1	-						FGF8_uc001ktq.1_Intron|FGF8_uc001ktr.1_Intron|FGF8_uc001kts.1_Intron|FGF8_uc009xwr.1_Intron	NM_033164	NP_149354			fibroblast growth factor 8 isoform E precursor						bone development|dopaminergic neuron differentiation|fibroblast growth factor receptor signaling pathway|gastrulation|gonad development|insulin receptor signaling pathway|mesonephros development|metanephros development|negative regulation of cardiac muscle tissue development|neuroepithelial cell differentiation|odontogenesis|positive regulation of cell division|positive regulation of cell proliferation	extracellular region|extracellular space	growth factor activity|growth factor activity|type 1 fibroblast growth factor receptor binding|type 2 fibroblast growth factor receptor binding				0		Colorectal(252;0.122)		Epithelial(162;3.94e-09)|all cancers(201;2.13e-07)														---	---	---	---
C10orf76	79591	broad.mit.edu	37	10	103717568	103717568	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:103717568delA	uc009xwy.1	-						C10orf76_uc009xwx.1_Intron	NM_024541	NP_078817			hypothetical protein LOC79591							integral to membrane					0		Colorectal(252;0.123)		Epithelial(162;2.41e-08)|all cancers(201;6.41e-07)														---	---	---	---
NFKB2	4791	broad.mit.edu	37	10	104155917	104155917	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:104155917delG	uc001kvb.2	+						NFKB2_uc001kva.2_Intron|NFKB2_uc010qqk.1_Intron|NFKB2_uc001kvd.2_Intron|NFKB2_uc009xxc.2_Intron	NM_001077494	NP_001070962			nuclear factor of kappa light polypeptide gene						innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	Bcl3/NF-kappaB2 complex|cytosol|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			lung(3)	3		Colorectal(252;0.00957)		Epithelial(162;3.4e-08)|all cancers(201;6.41e-07)				T	IGH@	B-NHL								---	---	---	---
NFKB2	4791	broad.mit.edu	37	10	104158163	104158163	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:104158163delC	uc001kvb.2	+	11	1139	c.874delC	c.(874-876)CCCfs	p.P292fs	NFKB2_uc001kva.2_Frame_Shift_Del_p.P292fs|NFKB2_uc010qqk.1_Frame_Shift_Del_p.P292fs|NFKB2_uc001kvd.2_Frame_Shift_Del_p.P292fs|NFKB2_uc009xxc.2_Frame_Shift_Del_p.P292fs	NM_001077494	NP_001070962	Q00653	NFKB2_HUMAN	nuclear factor of kappa light polypeptide gene	292	RHD.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	Bcl3/NF-kappaB2 complex|cytosol|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			lung(3)	3		Colorectal(252;0.00957)		Epithelial(162;3.4e-08)|all cancers(201;6.41e-07)				T	IGH@	B-NHL								---	---	---	---
SLK	9748	broad.mit.edu	37	10	105778499	105778499	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:105778499delA	uc001kxo.1	+						SLK_uc001kxp.1_Intron	NM_014720	NP_055535			serine/threonine kinase 2						apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			ovary(2)|stomach(2)|skin(2)|lung(1)|kidney(1)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)														---	---	---	---
CCDC147	159686	broad.mit.edu	37	10	106152248	106152248	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:106152248delA	uc001kyh.2	+							NM_001008723	NP_001008723			coiled-coil domain containing 147											ovary(2)|central_nervous_system(2)|skin(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)														---	---	---	---
SORCS3	22986	broad.mit.edu	37	10	106865213	106865213	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:106865213delT	uc001kyi.1	+	7	1379	c.1152delT	c.(1150-1152)CCTfs	p.P384fs		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	384	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity	p.P384L(1)		ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)														---	---	---	---
SORCS1	114815	broad.mit.edu	37	10	108458821	108458821	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:108458821delA	uc001kym.2	-						SORCS1_uc001kyl.2_Intron|SORCS1_uc009xxs.2_Intron|SORCS1_uc001kyn.1_Intron|SORCS1_uc001kyo.2_Intron	NM_052918	NP_443150			SORCS receptor 1 isoform a							integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)														---	---	---	---
PDCD4	27250	broad.mit.edu	37	10	112649148	112649148	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:112649148delT	uc001kzh.2	+						PDCD4_uc001kzg.2_Intron|PDCD4_uc010qre.1_Intron	NM_014456	NP_055271			programmed cell death 4 isoform 1						apoptosis|cell aging|negative regulation of cell cycle|negative regulation of JUN kinase activity|negative regulation of transcription, DNA-dependent	cytosol|nucleus	protein binding|RNA binding			ovary(1)|breast(1)|skin(1)	3		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.000526)|all cancers(201;0.00794)|BRCA - Breast invasive adenocarcinoma(275;0.125)														---	---	---	---
VTI1A	143187	broad.mit.edu	37	10	114297977	114297977	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:114297977delT	uc001kzy.2	+						VTI1A_uc001kzz.2_Intron	NM_145206	NP_660207			SNARE Vti1a-beta protein						intracellular protein transport|retrograde transport, endosome to Golgi	SNARE complex	protein transporter activity|SNAP receptor activity			ovary(1)	1		Colorectal(252;0.0314)|Breast(234;0.183)		Epithelial(162;0.0126)|all cancers(201;0.0487)														---	---	---	---
HABP2	3026	broad.mit.edu	37	10	115338240	115338240	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:115338240delT	uc001lai.3	+						HABP2_uc010qrz.1_Intron|HABP2_uc010qry.1_Intron	NM_004132	NP_004123			hyaluronan binding protein 2 preproprotein						cell adhesion|proteolysis	extracellular space	glycosaminoglycan binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3		Colorectal(252;0.0233)|Breast(234;0.0672)		Epithelial(162;0.00319)|all cancers(201;0.0112)														---	---	---	---
CASP7	840	broad.mit.edu	37	10	115481532	115481532	+	Frame_Shift_Del	DEL	A	-	-	rs72431166		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:115481532delA	uc001lan.2	+	4	544	c.370delA	c.(370-372)AAAfs	p.K124fs	CASP7_uc001lam.2_Frame_Shift_Del_p.K124fs|CASP7_uc001lao.2_Frame_Shift_Del_p.K157fs|CASP7_uc001lap.2_Frame_Shift_Del_p.K124fs|CASP7_uc001laq.2_Frame_Shift_Del_p.K124fs|CASP7_uc010qsa.1_Frame_Shift_Del_p.K209fs|CASP7_uc010qsb.1_Frame_Shift_Del_p.K99fs	NM_033339	NP_203125	P55210	CASP7_HUMAN	caspase 7 isoform alpha	124					activation of caspase activity by cytochrome c|cellular component disassembly involved in apoptosis|induction of apoptosis by intracellular signals|proteolysis	cytosol|endoplasmic reticulum membrane|mitochondrial membrane|nucleoplasm	cysteine-type endopeptidase activity|protein binding			ovary(1)	1		Colorectal(252;0.0946)|Breast(234;0.188)		Epithelial(162;0.012)|all cancers(201;0.014)														---	---	---	---
C10orf81	79949	broad.mit.edu	37	10	115535768	115535768	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:115535768delA	uc001lat.1	+						C10orf81_uc001lar.1_Intron|C10orf81_uc009xyc.1_Intron|C10orf81_uc001las.1_Intron|C10orf81_uc001lau.1_Intron	NM_024889	NP_079165			hypothetical protein LOC79949											central_nervous_system(1)	1		Colorectal(252;0.175)		Epithelial(162;0.0181)|all cancers(201;0.0204)														---	---	---	---
FAM160B1	57700	broad.mit.edu	37	10	116590564	116590565	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:116590564_116590565insT	uc001lcb.2	+						FAM160B1_uc001lcc.2_Intron	NM_020940	NP_065991			hypothetical protein LOC57700 isoform a											lung(1)	1																		---	---	---	---
ATRNL1	26033	broad.mit.edu	37	10	117024917	117024917	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:117024917delT	uc001lcg.2	+							NM_207303	NP_997186			attractin-like 1 precursor							integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)														---	---	---	---
PNLIP	5406	broad.mit.edu	37	10	118313457	118313459	+	Intron	DEL	AAA	-	-	rs72574709		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:118313457_118313459delAAA	uc001lcm.2	+							NM_000936	NP_000927			pancreatic lipase precursor						lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|skin(1)	3				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)													---	---	---	---
PNLIPRP2	5408	broad.mit.edu	37	10	118396279	118396279	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:118396279delT	uc001lcq.2	+						PNLIPRP2_uc009xyv.1_Intron	NM_005396	NP_005387			pancreatic lipase-related protein 2						galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			large_intestine(1)	1				all cancers(201;0.015)														---	---	---	---
Unknown	0	broad.mit.edu	37	10	118969993	118969993	+	IGR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:118969993delA								KCNK18 (184 upstream) : SLC18A2 (30723 downstream)																																			---	---	---	---
EIF3A	8661	broad.mit.edu	37	10	120833461	120833463	+	Intron	DEL	AGA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:120833461_120833463delAGA	uc001ldu.2	-						EIF3A_uc010qsu.1_Intron	NM_003750	NP_003741			eukaryotic translation initiation factor 3,						formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity				0		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)														---	---	---	---
RGS10	6001	broad.mit.edu	37	10	121285672	121285672	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:121285672delA	uc001lee.2	-						RGS10_uc001lef.2_Intron|RGS10_uc001leg.2_Intron	NM_002925	NP_002916			regulator of G-protein signaling 10 isoform b						negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|protein binding|signal transducer activity				0		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.00105)|GBM - Glioblastoma multiforme(135;0.195)														---	---	---	---
TIAL1	7073	broad.mit.edu	37	10	121335157	121335157	+	3'UTR	DEL	T	-	-	rs73366847	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:121335157delT	uc001lei.1	-	12					TIAL1_uc001leh.1_3'UTR|TIAL1_uc001lej.1_3'UTR|TIAL1_uc001lek.1_3'UTR|TIAL1_uc009xzi.1_3'UTR	NM_003252	NP_003243			TIA-1 related protein isoform 1						apoptosis|defense response|induction of apoptosis|regulation of transcription from RNA polymerase II promoter	lysosome|nucleus|stress granule	nucleotide binding|RNA binding			ovary(1)	1		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.00239)|BRCA - Breast invasive adenocarcinoma(275;0.0932)														---	---	---	---
FGFR2	2263	broad.mit.edu	37	10	123310734	123310734	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:123310734delA	uc010qtk.1	-						FGFR2_uc010qtg.1_Intron|FGFR2_uc010qth.1_Intron|FGFR2_uc010qti.1_Intron|FGFR2_uc010qtj.1_Intron|FGFR2_uc010qtl.1_Intron|FGFR2_uc010qtm.1_Intron|FGFR2_uc001lfl.3_Intron|FGFR2_uc001lfm.2_Intron|FGFR2_uc001lfn.3_Intron|FGFR2_uc010qtn.1_Intron|FGFR2_uc010qto.1_Intron|FGFR2_uc001lfo.1_Intron|FGFR2_uc010qtp.1_Intron|FGFR2_uc010qtq.1_Intron	NM_000141	NP_000132			fibroblast growth factor receptor 2 isoform 1						angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			endometrium(44)|skin(28)|lung(11)|ovary(4)|cervix(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|soft_tissue(1)|central_nervous_system(1)	96		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)		5	Mis		gastric. NSCLC|endometrial		Crouzon|Pfeiffer|and Apert syndromes		Apert_syndrome|Saethre-Chotzen_syndrome				---	---	---	---
BTBD16	118663	broad.mit.edu	37	10	124034363	124034363	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:124034363delA	uc001lgc.1	+						BTBD16_uc001lgd.1_Intron	NM_144587	NP_653188			BTB (POZ) domain containing 16											skin(1)	1		all_neural(114;0.107)|Lung NSC(174;0.175)|all_lung(145;0.222)|Breast(234;0.238)																---	---	---	---
C10orf88	80007	broad.mit.edu	37	10	124711352	124711352	+	Intron	DEL	A	-	-	rs75488600		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:124711352delA	uc001lgw.2	-						C10orf88_uc001lgx.2_Intron	NM_024942	NP_079218			hypothetical protein LOC80007												0		all_neural(114;0.0765)|Lung NSC(174;0.163)|all_lung(145;0.205)		Colorectal(40;0.0686)|COAD - Colon adenocarcinoma(40;0.0735)														---	---	---	---
CHST15	51363	broad.mit.edu	37	10	125805497	125805498	+	Frame_Shift_Ins	INS	-	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:125805497_125805498insC	uc001lhl.2	-	1	744_745	c.231_232insG	c.(229-234)GGGAAGfs	p.G77fs	CHST15_uc001lhm.2_Frame_Shift_Ins_p.G77fs|CHST15_uc001lhn.2_Frame_Shift_Ins_p.G77fs|CHST15_uc010que.1_Frame_Shift_Ins_p.G77fs|CHST15_uc001lho.2_Frame_Shift_Ins_p.G77fs	NM_015892	NP_056976	Q7LFX5	CHSTF_HUMAN	B cell RAG associated protein	77_78	Cytoplasmic (Potential).				hexose biosynthetic process	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity			ovary(1)	1																		---	---	---	---
OAT	4942	broad.mit.edu	37	10	126086392	126086392	+	3'UTR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:126086392delA	uc001lhp.2	-	10					OAT_uc001lhq.2_RNA|OAT_uc001lhr.2_3'UTR	NM_000274	NP_000265			ornithine aminotransferase precursor						cellular amino acid biosynthetic process|visual perception	mitochondrial matrix	ornithine-oxo-acid transaminase activity|protein binding|pyridoxal phosphate binding				0		all_lung(145;0.0271)|Lung NSC(174;0.0436)|Colorectal(57;0.102)|all_neural(114;0.116)			L-Ornithine(DB00129)|Pyridoxal Phosphate(DB00114)													---	---	---	---
DHX32	55760	broad.mit.edu	37	10	127542779	127542779	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:127542779delA	uc001ljf.1	-						DHX32_uc001lje.1_5'UTR|DHX32_uc001ljg.1_Intron|DHX32_uc009yam.1_Intron	NM_018180	NP_060650			DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 32							mitochondrion|nucleus	ATP binding|helicase activity			breast(2)|ovary(1)|lung(1)	4		all_lung(145;0.00751)|Lung NSC(174;0.0115)|Colorectal(57;0.0846)|all_neural(114;0.0936)																---	---	---	---
DOCK1	1793	broad.mit.edu	37	10	128768952	128768952	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:128768952delT	uc001ljt.2	+						DOCK1_uc010qun.1_Intron	NM_001380	NP_001371			dedicator of cytokinesis 1						apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)														---	---	---	---
EBF3	253738	broad.mit.edu	37	10	131760494	131760495	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:131760494_131760495insA	uc001lki.1	-						EBF3_uc010qur.1_3'UTR	NM_001005463	NP_001005463			early B-cell factor 3						multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|pancreas(1)	2		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)														---	---	---	---
DRD4	1815	broad.mit.edu	37	11	639374	639374	+	Intron	DEL	C	-	-	rs71738587		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:639374delC	uc001lqp.1	+							NM_000797	NP_000788			dopamine receptor D4						activation of MAPK activity|adult locomotory behavior|arachidonic acid secretion|behavioral fear response|behavioral response to cocaine|behavioral response to ethanol|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cAMP biosynthetic process|negative regulation of protein secretion|positive regulation of sodium:hydrogen antiporter activity|regulation of dopamine metabolic process|regulation of inhibitory postsynaptic membrane potential|response to amphetamine|response to histamine|social behavior	integral to plasma membrane	dopamine D4 receptor activity|drug binding|potassium channel regulator activity|SH3 domain binding				0		all_cancers(49;1.69e-08)|all_epithelial(84;1.65e-05)|Breast(177;0.000231)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.36e-28)|Epithelial(43;2.59e-27)|OV - Ovarian serous cystadenocarcinoma(40;3.53e-21)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Apomorphine(DB00714)|Clozapine(DB00363)|Olanzapine(DB00334)|Pramipexole(DB00413)|Promazine(DB00420)|Propiomazine(DB00777)|Ropinirole(DB00268)|Thiethylperazine(DB00372)|Ziprasidone(DB00246)													---	---	---	---
MUC6	4588	broad.mit.edu	37	11	1032056	1032057	+	Intron	DEL	AC	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:1032056_1032057delAC	uc001lsw.2	-							NM_005961	NP_005952			mucin 6, gastric						maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)														---	---	---	---
MUC2	4583	broad.mit.edu	37	11	1077547	1077547	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:1077547delG	uc001lsx.1	+							NM_002457	NP_002448			mucin 2 precursor							inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)													---	---	---	---
KRTAP5-5	439915	broad.mit.edu	37	11	1651497	1651497	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:1651497delG	uc001lty.2	+	1	465	c.427delG	c.(427-429)GGGfs	p.G143fs		NM_001001480	NP_001001480	Q701N2	KRA55_HUMAN	keratin associated protein 5-5	143	8 X 4 AA repeats of C-C-X-P.					keratin filament				lung(1)	1		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)														---	---	---	---
MRPL23	6150	broad.mit.edu	37	11	1973987	1973987	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:1973987delT	uc001lux.2	+							NM_021134	NP_066957			mitochondrial ribosomal protein L23						translation	mitochondrial large ribosomal subunit	nucleotide binding|RNA binding|structural constituent of ribosome			large_intestine(2)|ovary(1)	3		all_epithelial(84;6.24e-05)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.0026)|Lung(200;0.0171)|LUSC - Lung squamous cell carcinoma(625;0.0842)												OREG0020673	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
TRPM5	29850	broad.mit.edu	37	11	2441272	2441286	+	Intron	DEL	CCCAGGCCCCCACGG	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:2441272_2441286delCCCAGGCCCCCACGG	uc001lwm.3	-						TRPM5_uc010qxl.1_Intron|TRPM5_uc009ydn.2_Intron	NM_014555	NP_055370			transient receptor potential cation channel,							integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)														---	---	---	---
KCNQ1	3784	broad.mit.edu	37	11	2798337	2798338	+	Intron	INS	-	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:2798337_2798338insC	uc001lwn.2	+						KCNQ1_uc009ydp.1_Intron|KCNQ1_uc001lwo.2_Intron	NM_000218	NP_000209			potassium voltage-gated channel, KQT-like						blood circulation|membrane depolarization|muscle contraction|sensory perception of sound		delayed rectifier potassium channel activity|protein binding			ovary(1)	1		all_epithelial(84;3.26e-05)|Breast(177;0.001)|Medulloblastoma(188;0.00111)|Ovarian(85;0.00158)|all_neural(188;0.00725)|all_lung(207;0.11)|Lung NSC(207;0.159)		BRCA - Breast invasive adenocarcinoma(625;0.00251)|Lung(200;0.131)	Bepridil(DB01244)|Indapamide(DB00808)													---	---	---	---
OR52A5	390054	broad.mit.edu	37	11	5153679	5153679	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:5153679delA	uc010qyx.1	-	1	194	c.194delT	c.(193-195)TTGfs	p.L65fs		NM_001005160	NP_001005160	Q9H2C5	O52A5_HUMAN	olfactory receptor, family 52, subfamily A,	65	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|lung(1)|central_nervous_system(1)	4		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)														---	---	---	---
OR51B5	282763	broad.mit.edu	37	11	5511098	5511099	+	Intron	INS	-	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:5511098_5511099insC	uc001maq.1	-						HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron	NM_001005567	NP_001005567			olfactory receptor, family 51, subfamily B,						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.05e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)														---	---	---	---
TRIM5	85363	broad.mit.edu	37	11	5701141	5701141	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:5701141delC	uc001mbm.1	-	2	524	c.267delG	c.(265-267)GGGfs	p.G89fs	TRIM5_uc001mbq.1_Frame_Shift_Del_p.G89fs|TRIM5_uc001mbl.1_RNA|TRIM5_uc001mbn.2_Frame_Shift_Del_p.G89fs|TRIM5_uc001mbo.2_Frame_Shift_Del_p.G89fs|TRIM5_uc001mbp.2_Frame_Shift_Del_p.G89fs	NM_033034	NP_149023	Q9C035	TRIM5_HUMAN	tripartite motif protein TRIM5 isoform alpha	89					interspecies interaction between organisms|protein trimerization|response to virus	cytoplasm|cytoplasmic mRNA processing body	ligase activity|protein binding|protein homodimerization activity|zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)|Lung NSC(207;0.138)|all_lung(207;0.221)		Epithelial(150;7.21e-09)|BRCA - Breast invasive adenocarcinoma(625;0.139)														---	---	---	---
Unknown	0	broad.mit.edu	37	11	6067272	6067272	+	IGR	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:6067272delC								OR56A1 (18338 upstream) : OR56B4 (61737 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	11	6067831	6067831	+	IGR	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:6067831delG								OR56A1 (18897 upstream) : OR56B4 (61178 downstream)																																			---	---	---	---
TRIM3	10612	broad.mit.edu	37	11	6472757	6472757	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:6472757delC	uc001mdh.2	-						TRIM3_uc001mdi.2_Intron|TRIM3_uc010raj.1_Intron|TRIM3_uc009yfd.2_Intron|TRIM3_uc010rak.1_Intron	NM_006458	NP_006449			tripartite motif-containing 3						nervous system development|protein transport	early endosome	protein C-terminus binding|zinc ion binding			central_nervous_system(2)|large_intestine(1)|ovary(1)|skin(1)	5		all_lung(207;9.97e-06)|Lung NSC(207;1.74e-05)|Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;9.34e-10)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.133)|BRCA - Breast invasive adenocarcinoma(625;0.135)														---	---	---	---
TMEM9B	56674	broad.mit.edu	37	11	8969711	8969711	+	3'UTR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:8969711delA	uc001mhe.1	-	5					TMEM9B_uc001mhf.1_3'UTR|TMEM9B_uc010rbt.1_3'UTR	NM_020644	NP_065695			TMEM9 domain family, member B precursor						positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	signal transducer activity				0				Epithelial(150;4.39e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0237)														---	---	---	---
NRIP3	56675	broad.mit.edu	37	11	9005478	9005478	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:9005478delC	uc001mhg.2	-	6	768	c.654delG	c.(652-654)GGGfs	p.G218fs	NRIP3_uc010rbu.1_3'UTR	NM_020645	NP_065696	Q9NQ35	NRIP3_HUMAN	nuclear receptor interacting protein 3	218					proteolysis		aspartic-type endopeptidase activity				0				Epithelial(150;4.77e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0241)														---	---	---	---
C11orf58	10944	broad.mit.edu	37	11	16766136	16766136	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:16766136delT	uc001mmk.2	+						C11orf58_uc010rct.1_Intron	NM_014267	NP_055082			small acidic protein isoform a												0																		---	---	---	---
PIK3C2A	5286	broad.mit.edu	37	11	17135716	17135716	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:17135716delT	uc001mmq.3	-						PIK3C2A_uc009ygu.1_Intron|PIK3C2A_uc010rcw.1_Intron|PIK3C2A_uc001mmr.3_Intron	NM_002645	NP_002636			phosphoinositide-3-kinase, class 2 alpha						cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(4)|central_nervous_system(4)|stomach(1)|ovary(1)	10					Phosphatidylserine(DB00144)													---	---	---	---
PIK3C2A	5286	broad.mit.edu	37	11	17190949	17190949	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:17190949delT	uc001mmq.3	-	1	406	c.340delA	c.(340-342)ACAfs	p.T114fs	PIK3C2A_uc009ygu.1_Intron|PIK3C2A_uc010rcw.1_Intron|PIK3C2A_uc001mmr.3_RNA|PIK3C2A_uc010rcx.1_Frame_Shift_Del_p.T114fs|PIK3C2A_uc009ygv.1_Frame_Shift_Del_p.T114fs	NM_002645	NP_002636	O00443	P3C2A_HUMAN	phosphoinositide-3-kinase, class 2 alpha	114	Interaction with clathrin.				cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(4)|central_nervous_system(4)|stomach(1)|ovary(1)	10					Phosphatidylserine(DB00144)													---	---	---	---
TPH1	7166	broad.mit.edu	37	11	18062087	18062087	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:18062087delT	uc001mnp.2	-						TPH1_uc009yhe.2_Intron	NM_004179	NP_004170			tryptophan hydroxylase 1						aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity				0					L-Tryptophan(DB00150)|Tetrahydrobiopterin(DB00360)													---	---	---	---
SPTY2D1	144108	broad.mit.edu	37	11	18636367	18636367	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:18636367delG	uc001moy.2	-	3	1670	c.1454delC	c.(1453-1455)CCGfs	p.P485fs	SPTY2D1_uc010rdi.1_Frame_Shift_Del_p.P485fs	NM_194285	NP_919261	Q68D10	SPT2_HUMAN	SPT2, Suppressor of Ty, domain containing 1	485	Ser-rich.									breast(1)	1																		---	---	---	---
ZDHHC13	54503	broad.mit.edu	37	11	19197720	19197720	+	3'UTR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:19197720delA	uc001mpi.2	+	17					ZDHHC13_uc001mpj.2_3'UTR	NM_019028	NP_061901			zinc finger, DHHC domain containing 13 isoform						positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi-associated vesicle membrane|integral to membrane	magnesium ion transmembrane transporter activity|palmitoyltransferase activity|signal transducer activity|zinc ion binding				0																		---	---	---	---
NAV2	89797	broad.mit.edu	37	11	19735105	19735105	+	5'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:19735105delT	uc010rdm.1	+	1					NAV2_uc001mpp.2_Intron|NAV2_uc001mpr.3_5'UTR|LOC100126784_uc010rdl.1_3'UTR	NM_145117	NP_660093			neuron navigator 2 isoform 2							nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6																		---	---	---	---
PRMT3	10196	broad.mit.edu	37	11	20414413	20414413	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:20414413delA	uc001mqb.2	+						PRMT3_uc001mqc.2_Intron|PRMT3_uc010rdn.1_Intron	NM_005788	NP_005779			protein arginine methyltransferase 3 isoform 1								zinc ion binding				0																		---	---	---	---
ANO5	203859	broad.mit.edu	37	11	22247514	22247514	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:22247514delT	uc001mqi.2	+						ANO5_uc001mqj.2_Intron	NM_213599	NP_998764			anoctamin 5 isoform a							chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4																		---	---	---	---
MUC15	143662	broad.mit.edu	37	11	26587427	26587427	+	5'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:26587427delT	uc001mqx.2	-	2					ANO3_uc010rdr.1_Intron|ANO3_uc001mqt.3_Intron|ANO3_uc010rds.1_Intron|ANO3_uc010rdt.1_Intron|MUC15_uc001mqw.2_Frame_Shift_Del_p.K20fs|MUC15_uc001mqy.2_Frame_Shift_Del_p.K20fs	NM_145650	NP_663625			mucin 15 isoform b							extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3																		---	---	---	---
CAT	847	broad.mit.edu	37	11	34493186	34493186	+	3'UTR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:34493186delA	uc001mvm.2	+	13					CAT_uc001mvn.2_3'UTR	NM_001752	NP_001743			catalase						hydrogen peroxide catabolic process|negative regulation of apoptosis|positive regulation of cell division|protein tetramerization|purine base metabolic process|purine nucleotide catabolic process|UV protection	peroxisomal matrix|peroxisomal membrane	catalase activity|heme binding|NADP binding|protein homodimerization activity			ovary(2)|pancreas(1)	3		Lung NSC(402;2.76e-08)|Acute lymphoblastic leukemia(5;0.00143)|all_hematologic(20;0.0116)|Melanoma(852;0.027)		BRCA - Breast invasive adenocarcinoma(625;0.000995)	Fomepizole(DB01213)													---	---	---	---
CD44	960	broad.mit.edu	37	11	35243397	35243399	+	Intron	DEL	TTG	-	-	rs55821315		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:35243397_35243399delTTG	uc001mvu.2	+						CD44_uc001mvv.2_Intron|CD44_uc001mvw.2_Intron|CD44_uc001mvx.2_Intron|CD44_uc001mvy.2_Intron|CD44_uc001mwc.3_Intron|CD44_uc010rer.1_Intron|CD44_uc009ykh.2_Intron	NM_000610	NP_000601			CD44 antigen isoform 1 precursor						cell-cell adhesion|cell-matrix adhesion|interferon-gamma-mediated signaling pathway|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation	cell surface|Golgi apparatus|integral to plasma membrane	collagen binding|hyaluronic acid binding|receptor activity			pancreas(1)	1	all_cancers(35;0.212)|all_lung(20;0.0874)|all_epithelial(35;0.112)	all_hematologic(20;0.107)	STAD - Stomach adenocarcinoma(6;0.00731)		Hyaluronidase(DB00070)													---	---	---	---
COMMD9	29099	broad.mit.edu	37	11	36299820	36299820	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:36299820delA	uc001mwn.3	-						COMMD9_uc009ykj.2_Intron|COMMD9_uc010rfb.1_Intron	NM_014186	NP_054905			COMM domain containing 9 isoform 1											ovary(1)	1	all_lung(20;0.211)	all_hematologic(20;0.107)																---	---	---	---
LRRC4C	57689	broad.mit.edu	37	11	40135879	40135879	+	3'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:40135879delT	uc001mxa.1	-	2					LRRC4C_uc001mxc.1_3'UTR|LRRC4C_uc001mxd.1_3'UTR|LRRC4C_uc001mxb.1_3'UTR	NM_020929	NP_065980			netrin-G1 ligand precursor						regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)																---	---	---	---
PHF21A	51317	broad.mit.edu	37	11	45955388	45955389	+	3'UTR	DEL	TC	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:45955388_45955389delTC	uc001ncc.3	-	18					PHF21A_uc001ncb.3_3'UTR|PHF21A_uc009ykx.2_3'UTR|PHF21A_uc001nca.1_3'UTR	NM_001101802	NP_001095272			BRAF35/HDAC2 complex isoform a						blood coagulation|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2																		---	---	---	---
CKAP5	9793	broad.mit.edu	37	11	46786930	46786930	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:46786930delA	uc001ndi.1	-						CKAP5_uc009ylg.1_Intron|CKAP5_uc001ndj.1_Intron|CKAP5_uc001ndh.1_Intron|SNORD67_uc001ndk.2_5'Flank	NM_001008938	NP_001008938			colonic and hepatic tumor over-expressed protein						cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2																		---	---	---	---
ARFGAP2	84364	broad.mit.edu	37	11	47189417	47189417	+	Intron	DEL	A	-	-	rs34204386		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:47189417delA	uc001ndt.2	-						ARFGAP2_uc010rha.1_Intron|ARFGAP2_uc010rhb.1_Intron|ARFGAP2_uc001ndu.2_Intron|ARFGAP2_uc010rhc.1_Intron	NM_032389	NP_115765			ADP-ribosylation factor GTPase activating						protein transport|regulation of ARF GTPase activity|vesicle-mediated transport	Golgi membrane|nucleolus|plasma membrane	ARF GTPase activator activity|zinc ion binding			ovary(1)	1																		---	---	---	---
NDUFS3	4722	broad.mit.edu	37	11	47602712	47602712	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:47602712delT	uc001nga.2	+						NDUFS3_uc001nft.3_Intron|KBTBD4_uc001nfw.1_5'Flank|KBTBD4_uc001nfx.2_5'Flank|KBTBD4_uc001nfz.2_5'Flank|KBTBD4_uc001nfy.2_5'Flank|NDUFS3_uc010rhn.1_3'UTR	NM_004551	NP_004542			NADH dehydrogenase (ubiquinone) Fe-S protein 3						induction of apoptosis|mitochondrial electron transport, NADH to ubiquinone|negative regulation of cell growth|reactive oxygen species metabolic process|transport	mitochondrial respiratory chain complex I	electron carrier activity|NADH dehydrogenase (ubiquinone) activity|protein binding				0					NADH(DB00157)													---	---	---	---
FNBP4	23360	broad.mit.edu	37	11	47786589	47786589	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:47786589delA	uc009ylv.2	-						FNBP4_uc001ngj.2_Intron|FNBP4_uc001ngl.2_Intron	NM_015308	NP_056123			formin binding protein 4											ovary(1)	1																		---	---	---	---
NUP160	23279	broad.mit.edu	37	11	47839594	47839594	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:47839594delT	uc001ngm.2	-						NUP160_uc009ylw.2_Intron	NM_015231	NP_056046			nucleoporin 160kDa						carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7																		---	---	---	---
NUP160	23279	broad.mit.edu	37	11	47841147	47841147	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:47841147delT	uc001ngm.2	-						NUP160_uc009ylw.2_Intron	NM_015231	NP_056046			nucleoporin 160kDa						carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7																		---	---	---	---
NUP160	23279	broad.mit.edu	37	11	47843814	47843815	+	Intron	DEL	TT	-	-	rs71875671		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:47843814_47843815delTT	uc001ngm.2	-						NUP160_uc009ylw.2_Intron	NM_015231	NP_056046			nucleoporin 160kDa						carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7																		---	---	---	---
PTPRJ	5795	broad.mit.edu	37	11	48171566	48171567	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:48171566_48171567insT	uc001ngp.3	+							NM_002843	NP_002834			protein tyrosine phosphatase, receptor type, J						contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|kidney(3)|ovary(1)|skin(1)	8																		---	---	---	---
Unknown	0	broad.mit.edu	37	11	49860159	49860159	+	IGR	DEL	T	-	-	rs112842155		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:49860159delT								LOC440040 (28192 upstream) : OR4C13 (113816 downstream)																																			---	---	---	---
OR5D18	219438	broad.mit.edu	37	11	55587636	55587638	+	In_Frame_Del	DEL	CTT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55587636_55587638delCTT	uc010rin.1	+	1	531_533	c.531_533delCTT	c.(529-534)CACTTC>CAC	p.F179del		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	179	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)																---	---	---	---
OR8I2	120586	broad.mit.edu	37	11	55861672	55861672	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55861672delA	uc010rix.1	+	1	889	c.889delA	c.(889-891)AAAfs	p.K297fs		NM_001003750	NP_001003750	Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I,	297	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1	Esophageal squamous(21;0.00693)																	---	---	---	---
TNKS1BP1	85456	broad.mit.edu	37	11	57078042	57078042	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:57078042delA	uc001njr.2	-						TNKS1BP1_uc001njs.2_Intron|TNKS1BP1_uc009ymd.1_Intron	NM_033396	NP_203754			tankyrase 1-binding protein 1						nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)																---	---	---	---
SLC43A1	8501	broad.mit.edu	37	11	57252398	57252399	+	3'UTR	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:57252398_57252399delTT	uc001nkk.2	-	15					SLC43A1_uc001nkl.2_3'UTR	NM_003627	NP_003618			solute carrier family 43, member 1						cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	neutral amino acid transmembrane transporter activity				0																		---	---	---	---
MED19	219541	broad.mit.edu	37	11	57472387	57472387	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:57472387delA	uc001nla.1	-						MED19_uc001nlb.2_Intron	NM_153450	NP_703151			mediator complex subunit 19						regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(2)	2																		---	---	---	---
CTNND1	1500	broad.mit.edu	37	11	57571337	57571339	+	Intron	DEL	AAA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:57571337_57571339delAAA	uc001nmc.3	+						CTNND1_uc001nlh.1_Intron|CTNND1_uc001nlu.3_Intron|CTNND1_uc001nlt.3_Intron|CTNND1_uc001nls.3_Intron|CTNND1_uc001nlw.3_Intron|CTNND1_uc001nmf.3_Intron|CTNND1_uc001nmd.3_Intron|CTNND1_uc001nlk.3_Intron|CTNND1_uc001nme.3_Intron|CTNND1_uc001nll.3_Intron|CTNND1_uc001nmg.3_Intron|CTNND1_uc001nlj.3_Intron|CTNND1_uc001nlr.3_Intron|CTNND1_uc001nlp.3_Intron|CTNND1_uc001nlx.3_Intron|CTNND1_uc001nlz.3_Intron|CTNND1_uc009ymn.2_Intron|CTNND1_uc001nlm.3_Intron|CTNND1_uc001nly.3_Intron|CTNND1_uc001nmb.3_Intron|CTNND1_uc001nma.3_Intron|CTNND1_uc001nmi.3_Intron|CTNND1_uc001nmh.3_Intron|CTNND1_uc001nlq.3_Intron|CTNND1_uc001nln.3_Intron|CTNND1_uc001nli.3_Intron|CTNND1_uc001nlo.3_Intron|CTNND1_uc001nlv.3_Intron	NM_001085458	NP_001078927			catenin, delta 1 isoform 1ABC						adherens junction organization|cell junction assembly|negative regulation of canonical Wnt receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytosol|midbody|nucleus	cadherin binding|protein binding|receptor binding			breast(4)|ovary(1)|kidney(1)	6		all_epithelial(135;0.155)																---	---	---	---
GIF	2694	broad.mit.edu	37	11	59599272	59599272	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:59599272delA	uc001noi.2	-							NM_005142	NP_005133			gastric intrinsic factor (vitamin B synthesis)						cobalamin metabolic process|cobalamin transport|cobalt ion transport	apical plasma membrane|endosome|extracellular space|microvillus	cobalamin binding			ovary(1)|liver(1)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	11	59845041	59845041	+	IGR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:59845041delA								MS4A3 (6454 upstream) : MS4A2 (11096 downstream)																																			---	---	---	---
MS4A6A	64231	broad.mit.edu	37	11	59945973	59945973	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:59945973delA	uc001nor.2	-						MS4A6A_uc001noq.2_Intron|MS4A6A_uc001nos.3_Intron|MS4A6A_uc009ymv.2_Intron|MS4A6A_uc001not.2_Intron|MS4A6A_uc010rla.1_Intron|MS4A6A_uc010rlb.1_Intron	NM_152852	NP_690591			membrane-spanning 4-domains, subfamily A, member							integral to membrane	receptor activity				0																		---	---	---	---
MS4A4A	51338	broad.mit.edu	37	11	60068559	60068559	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:60068559delA	uc001noz.2	+						MS4A4A_uc001npa.2_Intron|MS4A4A_uc001npb.2_Intron|MS4A4A_uc001npc.2_Intron	NM_148975	NP_683876			membrane-spanning 4-domains, subfamily A, member							integral to membrane	receptor activity				0																		---	---	---	---
C11orf9	745	broad.mit.edu	37	11	61545815	61545815	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:61545815delC	uc001nsc.1	+						C11orf9_uc001nse.1_Intron|C11orf9_uc010rll.1_Intron	NM_001127392	NP_001120864			myelin gene regulatory factor isoform 2						central nervous system myelination|positive regulation of myelination|positive regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1																		---	---	---	---
INTS5	80789	broad.mit.edu	37	11	62414351	62414351	+	3'UTR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62414351delA	uc001nud.2	-	2					GANAB_uc001nua.2_5'Flank|GANAB_uc001nub.2_5'Flank|GANAB_uc001nuc.2_5'Flank|GANAB_uc010rma.1_5'Flank|GANAB_uc010rmb.1_5'Flank	NM_030628	NP_085131			integrator complex subunit 5						snRNA processing	integral to membrane|integrator complex	protein binding			ovary(2)	2																		---	---	---	---
NXF1	10482	broad.mit.edu	37	11	62561638	62561638	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62561638delA	uc001nvf.1	-						TMEM223_uc001nve.2_5'Flank|NXF1_uc001nvg.1_Intron	NM_006362	NP_006353			nuclear RNA export factor 1 isoform 1						gene expression|interspecies interaction between organisms	cytosol|nuclear speck	nucleotide binding|protein binding			skin(3)	3																		---	---	---	---
Unknown	0	broad.mit.edu	37	11	62799908	62799908	+	IGR	DEL	T	-	-	rs114064409	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62799908delT								SLC22A8 (16597 upstream) : SLC22A24 (47506 downstream)																																			---	---	---	---
RTN3	10313	broad.mit.edu	37	11	63525788	63525788	+	3'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:63525788delT	uc001nxq.2	+	9					RTN3_uc001nxo.2_3'UTR|RTN3_uc001nxm.2_3'UTR|RTN3_uc001nxn.2_3'UTR|RTN3_uc001nxp.2_3'UTR|RTN3_uc009yov.2_3'UTR|RTN3_uc010rmt.1_RNA|RTN3_uc010rmu.1_Frame_Shift_Del_p.A190fs	NM_201428	NP_958831			reticulon 3 isoform b						apoptosis|endoplasmic reticulum tubular network organization|interspecies interaction between organisms|response to stress|vesicle-mediated transport	endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane				ovary(1)	1																		---	---	---	---
VEGFB	7423	broad.mit.edu	37	11	64003843	64003843	+	Intron	DEL	G	-	-	rs11603042	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:64003843delG	uc001nyw.2	+						VEGFB_uc001nyx.2_Intron	NM_003377	NP_003368			vascular endothelial growth factor B precursor						anti-apoptosis|induction of positive chemotaxis|negative regulation of gene expression|negative regulation of neuron apoptosis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of endothelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of mast cell chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of vascular wound healing|vascular endothelial growth factor receptor signaling pathway	extracellular region|extracellular space|membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity|heparin binding|vascular endothelial growth factor receptor 1 binding				0																		---	---	---	---
SF1	7536	broad.mit.edu	37	11	64541002	64541002	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:64541002delA	uc001obb.1	-						SF1_uc010rnn.1_Intron|SF1_uc001oaz.1_Intron|SF1_uc001oba.1_Intron|SF1_uc001obc.1_Intron|SF1_uc001obd.1_Intron|SF1_uc001obe.1_Intron|SF1_uc010rno.1_Intron	NM_004630	NP_004621			splicing factor 1 isoform 1						nuclear mRNA 3'-splice site recognition|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ribosome|spliceosomal complex	protein binding|RNA binding|transcription corepressor activity|zinc ion binding			ovary(1)|breast(1)|skin(1)	3																		---	---	---	---
MEN1	4221	broad.mit.edu	37	11	64573491	64573491	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:64573491delA	uc001obj.2	-						MAP4K2_uc001obh.2_5'Flank|MAP4K2_uc001obi.2_5'Flank|MAP4K2_uc010rnp.1_5'Flank|MEN1_uc001obk.2_Intron|MEN1_uc001obl.2_Intron|MEN1_uc001obm.2_Intron|MEN1_uc001obn.2_Intron|MEN1_uc001obo.2_Intron|MEN1_uc001obp.2_Intron|MEN1_uc001obq.2_Intron|MEN1_uc001obr.2_Intron	NM_130800	NP_570712			menin isoform 1						DNA repair|histone lysine methylation|MAPKKK cascade|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of JNK cascade|negative regulation of osteoblast differentiation|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of telomerase activity|negative regulation of transcription from RNA polymerase II promoter|osteoblast development|positive regulation of protein binding|positive regulation of transforming growth factor beta receptor signaling pathway|response to gamma radiation|response to UV|transcription, DNA-dependent	chromatin|cleavage furrow|cytosol|histone methyltransferase complex|nuclear matrix|soluble fraction	double-stranded DNA binding|four-way junction DNA binding|protein binding, bridging|protein N-terminus binding|R-SMAD binding|transcription regulatory region DNA binding|Y-form DNA binding			parathyroid(105)|pancreas(64)|gastrointestinal_tract_(site_indeterminate)(15)|small_intestine(13)|lung(9)|pituitary(7)|NS(7)|adrenal_gland(5)|soft_tissue(4)|central_nervous_system(4)|thymus(2)|stomach(1)|retroperitoneum(1)|skin(1)	238								D|Mis|N|F|S		parathyroid tumors|Pancreatic neuroendocrine tumors	parathyroid adenoma|pituitary adenoma|pancreatic islet cell|carcinoid			Hyperparathyroidism_Familial_Isolated|Multiple_Endocrine_Neoplasia_type_1				---	---	---	---
MALAT1	378938	broad.mit.edu	37	11	65268925	65268925	+	RNA	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65268925delC	uc010roh.1	+	1		c.3693delC			uc001ody.2_RNA|MALAT1_uc001odz.2_5'Flank	NR_002819				Homo sapiens clone alpha1 mRNA sequence.												0																		---	---	---	---
LTBP3	4054	broad.mit.edu	37	11	65315174	65315174	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65315174delC	uc001oej.2	-	13	2234	c.1965delG	c.(1963-1965)GGGfs	p.G655fs	LTBP3_uc001oeg.2_5'Flank|LTBP3_uc001oeh.2_Frame_Shift_Del_p.G85fs|LTBP3_uc010roi.1_Frame_Shift_Del_p.G538fs|LTBP3_uc001oei.2_Frame_Shift_Del_p.G655fs|LTBP3_uc010roj.1_Frame_Shift_Del_p.G356fs|LTBP3_uc010rok.1_Frame_Shift_Del_p.G566fs	NM_001130144	NP_001123616	Q9NS15	LTBP3_HUMAN	latent transforming growth factor beta binding	655	EGF-like 4; calcium-binding (Potential).|Cys-rich.					extracellular region	calcium ion binding|growth factor binding			central_nervous_system(2)|lung(1)	3																		---	---	---	---
MAP3K11	4296	broad.mit.edu	37	11	65365835	65365835	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65365835delC	uc001oew.2	-	10	2964	c.2471delG	c.(2470-2472)GGCfs	p.G824fs	KCNK7_uc001oeq.2_5'Flank|KCNK7_uc001oer.2_5'Flank|KCNK7_uc001oes.2_5'Flank|KCNK7_uc001oeu.2_5'Flank|MAP3K11_uc001oev.2_Frame_Shift_Del_p.G240fs|MAP3K11_uc010rol.1_Frame_Shift_Del_p.G567fs|MAP3K11_uc001oex.1_Frame_Shift_Del_p.G313fs	NM_002419	NP_002410	Q16584	M3K11_HUMAN	mitogen-activated protein kinase kinase kinase	824	Pro-rich.				activation of JUN kinase activity|cell proliferation|G1 phase of mitotic cell cycle|microtubule-based process|positive regulation of JNK cascade|protein autophosphorylation	centrosome|microtubule	ATP binding|JUN kinase kinase kinase activity|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity			breast(3)|lung(1)|central_nervous_system(1)|skin(1)	6																		---	---	---	---
DRAP1	10589	broad.mit.edu	37	11	65688997	65688997	+	3'UTR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65688997delA	uc001ogj.1	+	7					C11orf68_uc009yqv.2_5'Flank|C11orf68_uc001ogi.2_5'Flank	NM_006442	NP_006433			DR1-associated protein 1						negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0				READ - Rectum adenocarcinoma(159;0.166)														---	---	---	---
CATSPER1	117144	broad.mit.edu	37	11	65784658	65784658	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65784658delG	uc001ogt.2	-							NM_053054	NP_444282			sperm-associated cation channel 1						cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			ovary(2)	2																		---	---	---	---
SF3B2	10992	broad.mit.edu	37	11	65822610	65822610	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65822610delC	uc001ogy.1	+	4	362	c.322delC	c.(322-324)CCCfs	p.P108fs	SF3B2_uc001ogx.1_Frame_Shift_Del_p.P108fs	NM_006842	NP_006833	Q13435	SF3B2_HUMAN	splicing factor 3B subunit 2	108	Poly-Pro.				interspecies interaction between organisms	catalytic step 2 spliceosome|nucleoplasm|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(2)|breast(1)	3																		---	---	---	---
NPAS4	266743	broad.mit.edu	37	11	66193413	66193416	+	Intron	DEL	TCTA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66193413_66193416delTCTA	uc001ohx.1	+						NPAS4_uc010rpc.1_Intron	NM_178864	NP_849195			neuronal PAS domain protein 4						transcription, DNA-dependent		DNA binding|signal transducer activity				0																		---	---	---	---
BBS1	582	broad.mit.edu	37	11	66282291	66282291	+	Intron	DEL	T	-	-	rs72050815		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66282291delT	uc001oij.1	+						BBS1_uc001oii.1_Intron|BBS1_uc010rpf.1_Intron|BBS1_uc010rpg.1_Intron|BBS1_uc001oik.1_Intron|BBS1_uc001oil.1_Intron	NM_024649	NP_078925			Bardet-Biedl syndrome 1						nonmotile primary cilium assembly|photoreceptor cell maintenance|response to stimulus|retina homeostasis	BBSome|cilium membrane|cytoplasm	protein binding			ovary(1)	1														Bardet-Biedl_syndrome				---	---	---	---
RBM4B	83759	broad.mit.edu	37	11	66436819	66436821	+	Intron	DEL	CTC	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66436819_66436821delCTC	uc001oja.2	-						RBM4B_uc001ojb.2_Intron	NM_031492	NP_113680			RNA binding motif protein 4B						circadian regulation of gene expression|entrainment of circadian clock by photoperiod|mRNA processing|RNA splicing	nucleolus	nucleotide binding|RNA binding|zinc ion binding				0																		---	---	---	---
C11orf80	79703	broad.mit.edu	37	11	66529499	66529499	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66529499delT	uc001ojf.2	+						C11orf80_uc001ojg.2_Intron|C11orf80_uc001ojh.2_Intron|C11orf80_uc001oji.2_Intron|C11orf80_uc010rpk.1_Intron	NM_024650	NP_078926			hypothetical protein LOC79703												0																		---	---	---	---
CHKA	1119	broad.mit.edu	37	11	67829387	67829388	+	Intron	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:67829387_67829388delAA	uc001onj.2	-						CHKA_uc001onk.2_Intron|uc001onl.1_5'Flank	NM_001277	NP_001268			choline kinase alpha isoform a						lipid transport|phosphatidylethanolamine biosynthetic process	cytoplasm	ATP binding|choline kinase activity|drug binding|ethanolamine kinase activity|signal transducer activity			ovary(1)|central_nervous_system(1)	2					Choline(DB00122)													---	---	---	---
LRP5	4041	broad.mit.edu	37	11	68131124	68131125	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:68131124_68131125insA	uc001ont.2	+						LRP5_uc009ysg.2_Intron	NM_002335	NP_002326			low density lipoprotein receptor-related protein						adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7																		---	---	---	---
PPFIA1	8500	broad.mit.edu	37	11	70170435	70170436	+	Intron	DEL	TG	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:70170435_70170436delTG	uc001opo.2	+						PPFIA1_uc001opn.1_Intron|PPFIA1_uc001opp.2_Intron|PPFIA1_uc001opq.1_5'Flank	NM_003626	NP_003617			PTPRF interacting protein alpha 1 isoform b						cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)															---	---	---	---
NUMA1	4926	broad.mit.edu	37	11	71716312	71716313	+	Frame_Shift_Ins	INS	-	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:71716312_71716313insG	uc001orl.1	-	23	5967_5968	c.5795_5796insC	c.(5794-5796)CCAfs	p.P1932fs	IL18BP_uc009ysu.1_Intron|NUMA1_uc001orj.2_Frame_Shift_Ins_p.P114fs|NUMA1_uc009ysw.1_Frame_Shift_Ins_p.P1499fs|NUMA1_uc001ork.1_Frame_Shift_Ins_p.P796fs|NUMA1_uc001orm.1_Frame_Shift_Ins_p.P1918fs	NM_006185	NP_006176	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	1932					G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			ovary(3)|lung(2)|skin(2)|central_nervous_system(1)	8								T	RARA	APL								---	---	---	---
CLPB	81570	broad.mit.edu	37	11	72091550	72091550	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:72091550delA	uc001osj.2	-						CLPB_uc010rqx.1_Intron|CLPB_uc010rqy.1_Intron|CLPB_uc001osk.2_Intron|CLPB_uc009ytg.2_Intron|CLPB_uc010rqz.1_Intron	NM_030813	NP_110440			caseinolytic peptidase B						cellular response to heat		ATP binding|nucleoside-triphosphatase activity|protein binding			pancreas(1)	1																		---	---	---	---
PDE2A	5138	broad.mit.edu	37	11	72307501	72307508	+	Intron	DEL	ATCTCTCT	-	-	rs145397044		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:72307501_72307508delATCTCTCT	uc010rrc.1	-						PDE2A_uc001oso.2_Intron|PDE2A_uc010rra.1_Intron|PDE2A_uc001osn.2_Intron|PDE2A_uc010rrb.1_Intron|PDE2A_uc010rrd.1_Intron	NM_002599	NP_002590			phosphodiesterase 2A isoform 1						platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(2)|breast(1)|skin(1)	4			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)													---	---	---	---
MRPL48	51642	broad.mit.edu	37	11	73519351	73519353	+	Intron	DEL	CTT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:73519351_73519353delCTT	uc001ouh.3	+						MRPL48_uc009ytt.2_Intron|MRPL48_uc010rri.1_Intron|MRPL48_uc009ytu.2_Intron	NM_016055	NP_057139			mitochondrial ribosomal protein L48 precursor						translation	mitochondrial ribosome	protein binding|structural constituent of ribosome				0																		---	---	---	---
C2CD3	26005	broad.mit.edu	37	11	73765451	73765452	+	Intron	DEL	AT	-	-	rs826089	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:73765451_73765452delAT	uc001ouu.2	-						C2CD3_uc001out.2_Intron	NM_015531	NP_056346			C2 calcium-dependent domain containing 3							centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)																	---	---	---	---
SPCS2	9789	broad.mit.edu	37	11	74677007	74677008	+	Intron	INS	-	T	T	rs117854160	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:74677007_74677008insT	uc001ovu.2	+							NM_014752	NP_055567			signal peptidase complex subunit 2 homolog						energy reserve metabolic process|regulation of insulin secretion|signal peptide processing	integral to membrane|microsome|signal peptidase complex	peptidase activity			breast(1)	1																		---	---	---	---
SLCO2B1	11309	broad.mit.edu	37	11	74862486	74862486	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:74862486delG	uc001owb.2	+						SLCO2B1_uc010rrp.1_Intron|SLCO2B1_uc010rrq.1_Intron|SLCO2B1_uc010rrr.1_Intron|SLCO2B1_uc010rrs.1_Intron|SLCO2B1_uc001owc.2_Intron	NM_007256	NP_009187			solute carrier organic anion transporter family,						sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			ovary(1)|breast(1)	2					Ergoloid mesylate(DB01049)													---	---	---	---
PAK1	5058	broad.mit.edu	37	11	77060170	77060173	+	Intron	DEL	AAAA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:77060170_77060173delAAAA	uc001oyh.3	-						PAK1_uc010rso.1_Intron|PAK1_uc001oyg.3_Intron|PAK1_uc001oyi.1_Intron|PAK1_uc010rsn.1_Intron	NM_002576	NP_002567			p21-activated kinase 1 isoform 2						apoptosis|axon guidance|cytoskeleton organization|ER-nucleus signaling pathway|positive regulation of JUN kinase activity|positive regulation of peptidyl-serine phosphorylation|protein autophosphorylation|T cell costimulation|T cell receptor signaling pathway	cytosol|focal adhesion|Golgi apparatus	ATP binding|collagen binding|protein binding|protein serine/threonine kinase activity			skin(2)|stomach(1)|lung(1)	4	all_cancers(14;1.75e-18)																	---	---	---	---
RSF1	51773	broad.mit.edu	37	11	77394602	77394602	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:77394602delA	uc001oyn.2	-						RSF1_uc001oym.2_Intron	NM_016578	NP_057662			remodeling and spacing factor 1						CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)															---	---	---	---
RSF1	51773	broad.mit.edu	37	11	77524322	77524322	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:77524322delT	uc001oyn.2	-						RSF1_uc001oyo.1_Intron	NM_016578	NP_057662			remodeling and spacing factor 1						CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)															---	---	---	---
C11orf82	220042	broad.mit.edu	37	11	82641183	82641183	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:82641183delT	uc001ozt.2	+						C11orf82_uc010rsr.1_Intron|C11orf82_uc010rss.1_Intron|C11orf82_uc009yvd.2_Intron	NM_145018	NP_659455			nitric oxide-inducible gene protein						apoptosis|cell cycle arrest	cytoplasm|nucleus				ovary(2)	2																		---	---	---	---
ANKRD42	338699	broad.mit.edu	37	11	82923946	82923946	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:82923946delT	uc001ozz.1	+						ANKRD42_uc009yvi.1_3'UTR|ANKRD42_uc010rsv.1_Intron|ANKRD42_uc001paa.2_Intron|ANKRD42_uc001pab.1_Intron	NM_182603	NP_872409			ankyrin repeat domain 42											skin(1)	1																		---	---	---	---
CCDC90B	60492	broad.mit.edu	37	11	82976819	82976819	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:82976819delT	uc001pae.2	-						CCDC90B_uc001pac.2_Intron|CCDC90B_uc001pad.2_Intron|CCDC90B_uc001paf.2_Intron	NM_021825	NP_068597			coiled-coil domain containing 90B precursor							integral to membrane|mitochondrion|mitochondrion					0		Acute lymphoblastic leukemia(157;0.103)																---	---	---	---
DLG2	1740	broad.mit.edu	37	11	83195297	83195297	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:83195297delA	uc001paj.2	-						DLG2_uc001pai.2_Intron|DLG2_uc010rsy.1_Intron|DLG2_uc010rsz.1_Intron|DLG2_uc010rta.1_Intron|DLG2_uc001pak.2_Intron|DLG2_uc010rtb.1_Intron|DLG2_uc010rsw.1_Intron|DLG2_uc010rsx.1_Intron	NM_001364	NP_001355			chapsyn-110 isoform 2							cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)																---	---	---	---
KIAA1731	85459	broad.mit.edu	37	11	93454921	93454921	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:93454921delG	uc009ywb.1	+						KIAA1731_uc001pdu.1_Intron|SCARNA9_uc001pdv.2_RNA|KIAA1731_uc001pdw.1_5'Flank	NM_033395	NP_203753			hypothetical protein LOC85459							centrosome					0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)																---	---	---	---
SNORA8	654320	broad.mit.edu	37	11	93465067	93465067	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:93465067delA	uc001pec.2	-						TAF1D_uc001pdz.2_Intron|SNORA25_uc001pdy.3_5'Flank|SNORA32_uc009ywc.1_5'Flank|TAF1D_uc001pea.1_Intron|SNORD6_uc001peb.2_5'Flank					Homo sapiens cDNA: FLJ23363 fis, clone HEP15507.												0																		---	---	---	---
TAF1D	79101	broad.mit.edu	37	11	93468345	93468345	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:93468345delT	uc001pdz.2	-						SNORA8_uc001pec.2_RNA|TAF1D_uc001pea.1_Intron|SNORA8_uc009ywe.2_5'Flank|SNORD5_uc009ywf.1_5'Flank|SNORA18_uc009ywg.1_5'Flank|MIR1304_hsa-mir-1304|MI0006371_5'Flank|SNORA40_uc009ywh.2_RNA	NM_024116				TATA box binding protein (TBP)-associated						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding				0																		---	---	---	---
MED17	9440	broad.mit.edu	37	11	93535276	93535278	+	Intron	DEL	TTT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:93535276_93535278delTTT	uc001pem.3	+							NM_004268	NP_004259			mediator complex subunit 17						androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)																---	---	---	---
HEPHL1	341208	broad.mit.edu	37	11	93796646	93796647	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:93796646_93796647insT	uc001pep.2	+							NM_001098672	NP_001092142			hephaestin-like 1 precursor						copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)																---	---	---	---
AMOTL1	154810	broad.mit.edu	37	11	94602310	94602310	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:94602310delA	uc001pfb.2	+						AMOTL1_uc001pfc.2_Intron	NM_130847	NP_570899			angiomotin like 1							cytoplasm|tight junction	identical protein binding			ovary(1)|breast(1)	2		Acute lymphoblastic leukemia(157;2.38e-05)|all_hematologic(158;0.00824)																---	---	---	---
MTMR2	8898	broad.mit.edu	37	11	95578044	95578044	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:95578044delA	uc001pfu.2	-						MTMR2_uc001pfv.2_Intron|MTMR2_uc001pfs.2_Intron|MTMR2_uc001pft.2_Intron	NM_016156	NP_057240			myotubularin-related protein 2 isoform 1							nucleus	inositol or phosphatidylinositol phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			pancreas(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)																---	---	---	---
CNTN5	53942	broad.mit.edu	37	11	100170134	100170134	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:100170134delT	uc001pga.2	+						CNTN5_uc001pfz.2_Intron|CNTN5_uc001pgb.2_Intron|CNTN5_uc010ruk.1_Intron	NM_014361	NP_055176			contactin 5 isoform long						cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)														---	---	---	---
DCUN1D5	84259	broad.mit.edu	37	11	102953515	102953515	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:102953515delA	uc001phm.2	-	4	571	c.303delT	c.(301-303)TTTfs	p.F101fs	DCUN1D5_uc010ruw.1_Frame_Shift_Del_p.F32fs	NM_032299	NP_115675	Q9BTE7	DCNL5_HUMAN	DCN1, defective in cullin neddylation 1, domain	101	DCUN1.										0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.00032)|Epithelial(105;0.0689)|all cancers(92;0.186)														---	---	---	---
CASP5	838	broad.mit.edu	37	11	104874011	104874011	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:104874011delT	uc010rva.1	-	4	565	c.533delA	c.(532-534)AATfs	p.N178fs	CASP5_uc010ruz.1_Frame_Shift_Del_p.N191fs|CASP5_uc010rvb.1_Frame_Shift_Del_p.N120fs|CASP5_uc010rvc.1_Frame_Shift_Del_p.N36fs|CASP5_uc009yxh.2_Intron|CASP5_uc010rvd.1_Intron	NM_004347	NP_004338	P51878	CASP5_HUMAN	caspase 5 isoform a precursor	178					apoptosis|cellular response to mechanical stimulus|proteolysis|regulation of apoptosis	intracellular	cysteine-type endopeptidase activity|protein binding			ovary(2)|lung(1)	3		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000943)|Epithelial(105;0.0104)|all cancers(92;0.042)														---	---	---	---
GRIA4	2893	broad.mit.edu	37	11	105781021	105781021	+	Intron	DEL	T	-	-	rs113570660		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:105781021delT	uc001pix.2	+						GRIA4_uc001piu.1_Intron|GRIA4_uc001piw.2_Intron|GRIA4_uc009yxk.1_Intron	NM_000829	NP_000820			glutamate receptor, ionotrophic, AMPA 4 isoform						glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)													---	---	---	---
KBTBD3	143879	broad.mit.edu	37	11	105929470	105929470	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:105929470delT	uc001pja.2	-						KBTBD3_uc001pjb.2_Intron|KBTBD3_uc009yxm.2_Intron	NM_198439	NP_940841			BTB and kelch domain containing 3											ovary(1)|central_nervous_system(1)	2		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.43e-05)|Epithelial(105;0.00418)|all cancers(92;0.0299)														---	---	---	---
CWF19L2	143884	broad.mit.edu	37	11	107274881	107274881	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:107274881delT	uc010rvp.1	-						CWF19L2_uc001pjh.3_Intron|CWF19L2_uc009yxo.2_Intron	NM_152434	NP_689647			CWF19-like 2, cell cycle control								catalytic activity				0		Melanoma(852;1.75e-05)|all_epithelial(67;6.27e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0258)		Epithelial(105;7.18e-06)|BRCA - Breast invasive adenocarcinoma(274;1.65e-05)|all cancers(92;1.76e-05)														---	---	---	---
CUL5	8065	broad.mit.edu	37	11	107940724	107940724	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:107940724delT	uc001pjv.2	+						CUL5_uc001pju.2_Intron	NM_003478	NP_003469			Vasopressin-activated calcium-mobilizing						cell cycle arrest|cell proliferation|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process|viral reproduction	cullin-RING ubiquitin ligase complex|cytosol	calcium channel activity|receptor activity|ubiquitin protein ligase binding			ovary(1)	1		all_cancers(61;7.09e-10)|all_epithelial(67;2.97e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|Melanoma(852;4.48e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;3.58e-05)|Epithelial(105;4.68e-05)|all cancers(92;0.00122)|OV - Ovarian serous cystadenocarcinoma(223;0.217)														---	---	---	---
NPAT	4863	broad.mit.edu	37	11	108040773	108040773	+	Intron	DEL	A	-	-	rs35747263		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:108040773delA	uc001pjz.3	-						NPAT_uc010rvv.1_5'UTR	NM_002519	NP_002510			nuclear protein,  ataxia-telangiectasia locus						positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	protein C-terminus binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			ovary(2)	2		all_cancers(61;2.31e-10)|all_epithelial(67;1.11e-06)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;1.05e-05)|Epithelial(105;3.01e-05)|all cancers(92;0.000816)|Colorectal(284;0.116)														---	---	---	---
ATM	472	broad.mit.edu	37	11	108153393	108153393	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:108153393delT	uc001pkb.1	+						ATM_uc009yxr.1_Intron	NM_000051	NP_000042			ataxia telangiectasia mutated isoform 1						cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)				D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			---	---	---	---
ATM	472	broad.mit.edu	37	11	108203633	108203633	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:108203633delT	uc001pkb.1	+						ATM_uc009yxr.1_Intron|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_Intron|ATM_uc001pke.1_Intron|ATM_uc001pkg.1_Intron	NM_000051	NP_000042			ataxia telangiectasia mutated isoform 1						cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)				D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			---	---	---	---
LAYN	143903	broad.mit.edu	37	11	111425991	111425991	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:111425991delA	uc001plr.1	+	6	994	c.658delA	c.(658-660)AAAfs	p.K220fs	LAYN_uc001plp.1_Frame_Shift_Del_p.K212fs|LAYN_uc001plq.1_Frame_Shift_Del_p.K220fs|LAYN_uc001pls.1_Frame_Shift_Del_p.K212fs|LAYN_uc010rwg.1_Frame_Shift_Del_p.K67fs|LAYN_uc010rwh.1_Frame_Shift_Del_p.K68fs	NM_178834	NP_849156	Q6UX15	LAYN_HUMAN	layilin	220	Extracellular (Potential).					cell surface|integral to membrane|ruffle	hyaluronic acid binding|sugar binding				0		all_cancers(61;9.06e-10)|all_epithelial(67;1.34e-05)|Melanoma(852;1.74e-05)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Breast(348;0.086)		Epithelial(105;1.5e-06)|BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|all cancers(92;2.45e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0476)														---	---	---	---
SDHD	6392	broad.mit.edu	37	11	111958933	111958933	+	Intron	DEL	T	-	-	rs113282959		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:111958933delT	uc001pmz.2	+						TIMM8B_uc001pmx.2_5'Flank|TIMM8B_uc001pmy.2_5'Flank	NM_003002	NP_002993			succinate dehydrogenase complex, subunit D						respiratory electron transport chain|transport|tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain complex II	electron carrier activity|heme binding|succinate dehydrogenase activity|ubiquinone binding				0		all_cancers(61;5.7e-14)|all_epithelial(67;3.4e-08)|Melanoma(852;8.81e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;6.13e-07)|BRCA - Breast invasive adenocarcinoma(274;6.17e-07)|all cancers(92;1.05e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0515)	Succinic acid(DB00139)			Mis|N|F|S			paraganglioma|pheochromocytoma			Familial_Paragangliomas|Carney-Stratakis_syndrome|Cowden_syndrome				---	---	---	---
ANKK1	255239	broad.mit.edu	37	11	113266217	113266217	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:113266217delG	uc001pny.2	+							NM_178510	NP_848605			ankyrin repeat and kinase domain containing 1								ATP binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|ovary(1)|breast(1)	8		all_cancers(61;1.53e-11)|all_epithelial(67;3e-06)|Melanoma(852;4.04e-05)|all_hematologic(158;0.000315)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0461)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Prostate(24;0.194)		BRCA - Breast invasive adenocarcinoma(274;4.82e-06)|Epithelial(105;5.41e-05)|all cancers(92;0.000442)|OV - Ovarian serous cystadenocarcinoma(223;0.238)														---	---	---	---
FAM55D	54827	broad.mit.edu	37	11	114450759	114450759	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:114450759delA	uc001ppc.2	-						FAM55D_uc001ppd.2_Intron	NM_001077639	NP_001071107			hypothetical protein LOC54827 isoform 1							extracellular region				ovary(2)|skin(2)	4		all_cancers(61;8.53e-16)|all_epithelial(67;1.71e-08)|all_hematologic(158;3.05e-05)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0194)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;2.82e-06)|Epithelial(105;0.000129)|all cancers(92;0.000938)														---	---	---	---
ZNF259	8882	broad.mit.edu	37	11	116650308	116650308	+	Intron	DEL	A	-	-	rs36064778		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:116650308delA	uc001ppp.2	-						ZNF259_uc009yzd.2_Intron|ZNF259_uc001ppq.2_Intron	NM_003904	NP_003895			zinc finger protein 259						cell proliferation|signal transduction	cytoplasm|nucleolus					0	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.61e-06)|all cancers(92;0.000139)|OV - Ovarian serous cystadenocarcinoma(223;0.153)														---	---	---	---
SIK3	23387	broad.mit.edu	37	11	116906807	116906807	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:116906807delT	uc001ppy.2	-						SIK3_uc001ppz.2_Intron|SIK3_uc001pqa.2_Intron	NM_025164	NP_079440			serine/threonine-protein kinase QSK							cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|breast(3)|stomach(2)|lung(1)|skin(1)|kidney(1)	12																		---	---	---	---
RNF214	257160	broad.mit.edu	37	11	117110765	117110766	+	Intron	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:117110765_117110766delAA	uc001pqt.2	+						RNF214_uc001pqu.2_Intron|RNF214_uc010rxf.1_Intron	NM_207343	NP_997226			ring finger protein 214								zinc ion binding				0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.88e-05)|Epithelial(105;0.000397)|all cancers(92;0.00258)														---	---	---	---
DSCAML1	57453	broad.mit.edu	37	11	117298912	117298913	+	3'UTR	INS	-	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:117298912_117298913insG	uc001prh.1	-	33						NM_020693	NP_065744			Down syndrome cell adhesion molecule like 1						axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)														---	---	---	---
TMPRSS4	56649	broad.mit.edu	37	11	117975314	117975314	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:117975314delG	uc010rxo.1	+						TMPRSS4_uc010rxp.1_Intron|TMPRSS4_uc010rxq.1_Intron|TMPRSS4_uc010rxr.1_Intron|TMPRSS4_uc010rxs.1_Intron|TMPRSS4_uc009yzu.2_Intron|TMPRSS4_uc010rxt.1_Intron	NM_019894	NP_063947			transmembrane protease, serine 4 isoform 1						proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0431)|all_hematologic(192;0.164)|Breast(348;0.183)|all_neural(223;0.238)		BRCA - Breast invasive adenocarcinoma(274;4.16e-05)|Epithelial(105;0.00204)														---	---	---	---
TMPRSS4	56649	broad.mit.edu	37	11	117988220	117988220	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:117988220delG	uc010rxo.1	+						TMPRSS4_uc010rxp.1_Intron|TMPRSS4_uc010rxq.1_Intron|TMPRSS4_uc010rxr.1_Intron|TMPRSS4_uc010rxs.1_Intron|TMPRSS4_uc009yzu.2_Intron|TMPRSS4_uc010rxt.1_Intron	NM_019894	NP_063947			transmembrane protease, serine 4 isoform 1						proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0431)|all_hematologic(192;0.164)|Breast(348;0.183)|all_neural(223;0.238)		BRCA - Breast invasive adenocarcinoma(274;4.16e-05)|Epithelial(105;0.00204)														---	---	---	---
CD3E	916	broad.mit.edu	37	11	118185008	118185008	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118185008delA	uc001psq.3	+							NM_000733	NP_000724			CD3E antigen, epsilon polypeptide precursor						G-protein coupled receptor protein signaling pathway|signal complex assembly|T cell costimulation|T cell receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway	external side of plasma membrane|integral to plasma membrane	protein heterodimerization activity|protein kinase binding|receptor signaling complex scaffold activity|receptor signaling protein activity|SH3 domain binding|T cell receptor binding|transmembrane receptor activity			ovary(2)	2	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.09e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0251)	Muromonab(DB00075)													---	---	---	---
UBE4A	9354	broad.mit.edu	37	11	118252002	118252002	+	Intron	DEL	T	-	-	rs139803253	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118252002delT	uc001psw.2	+						UBE4A_uc001psv.2_Intron	NM_004788	NP_004779			ubiquitination factor E4A						ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	5	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)														---	---	---	---
CCDC84	338657	broad.mit.edu	37	11	118873663	118873663	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118873663delT	uc001pul.2	+						CCDC84_uc010ryk.1_Intron|CCDC84_uc010ryl.1_Intron|CCDC84_uc010rym.1_Intron	NM_198489	NP_940891			coiled-coil domain containing 84											ovary(1)	1	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_neural(223;0.224)|all_hematologic(192;0.243)		BRCA - Breast invasive adenocarcinoma(274;7.72e-05)														---	---	---	---
TECTA	7007	broad.mit.edu	37	11	120973343	120973343	+	5'Flank	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:120973343delT	uc010rzo.1	+							NM_005422	NP_005413			tectorin alpha precursor						cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)														---	---	---	---
TECTA	7007	broad.mit.edu	37	11	121036077	121036077	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:121036077delC	uc010rzo.1	+	16	5368	c.5368delC	c.(5368-5370)CCCfs	p.P1790fs		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	1790					cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)														---	---	---	---
TECTA	7007	broad.mit.edu	37	11	121039318	121039318	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:121039318delA	uc010rzo.1	+							NM_005422	NP_005413			tectorin alpha precursor						cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)														---	---	---	---
UBASH3B	84959	broad.mit.edu	37	11	122526825	122526825	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:122526825delC	uc001pyi.3	+	1	428	c.68delC	c.(67-69)ACCfs	p.T23fs		NM_032873	NP_116262	Q8TF42	UBS3B_HUMAN	ubiquitin associated and SH3 domain containing,	23						cytoplasm|nucleus	protein tyrosine phosphatase activity			central_nervous_system(1)	1		Breast(109;0.00254)|Medulloblastoma(222;0.00877)|Lung NSC(97;0.0183)|all_lung(97;0.0186)|all_neural(223;0.0381)|all_hematologic(192;0.104)		BRCA - Breast invasive adenocarcinoma(274;1.37e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0463)														---	---	---	---
CRTAM	56253	broad.mit.edu	37	11	122741787	122741787	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:122741787delA	uc001pyj.2	+						CRTAM_uc001pyk.2_Intron	NM_019604	NP_062550			class-I MHC-restricted T cell associated						cell recognition|detection of tumor cell|positive regulation of cytokine secretion|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	integral to membrane|plasma membrane	receptor binding			ovary(1)	1		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.28e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0308)														---	---	---	---
C11orf63	79864	broad.mit.edu	37	11	122811560	122811561	+	Intron	DEL	TC	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:122811560_122811561delTC	uc001pym.2	+							NM_024806	NP_079082			hypothetical protein LOC79864 isoform 1											ovary(3)	3		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)														---	---	---	---
C11orf63	79864	broad.mit.edu	37	11	122828409	122828410	+	Intron	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:122828409_122828410delAA	uc001pym.2	+							NM_024806	NP_079082			hypothetical protein LOC79864 isoform 1											ovary(3)	3		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)														---	---	---	---
VWA5A	4013	broad.mit.edu	37	11	123994642	123994642	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:123994642delA	uc001pzu.2	+						VWA5A_uc001pzr.2_Intron|VWA5A_uc001pzs.2_Intron|VWA5A_uc010sae.1_Intron|VWA5A_uc001pzt.2_Intron	NM_001130142	NP_001123614			BCSC-1 isoform 1											upper_aerodigestive_tract(1)|ovary(1)	2																		---	---	---	---
VWA5A	4013	broad.mit.edu	37	11	124013490	124013490	+	Intron	DEL	T	-	-	rs111751268		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:124013490delT	uc001pzu.2	+						VWA5A_uc001pzt.2_Intron	NM_001130142	NP_001123614			BCSC-1 isoform 1											upper_aerodigestive_tract(1)|ovary(1)	2																		---	---	---	---
NTM	50863	broad.mit.edu	37	11	132177538	132177538	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:132177538delT	uc001qgp.2	+						NTM_uc001qgm.2_Intron|NTM_uc010sch.1_Intron|NTM_uc010sci.1_Intron|NTM_uc010scj.1_Intron|NTM_uc001qgo.2_Intron|NTM_uc001qgq.2_Intron|NTM_uc001qgr.2_Intron	NM_016522	NP_057606			neurotrimin isoform 1						cell adhesion|neuron recognition	anchored to membrane|plasma membrane				ovary(4)|central_nervous_system(1)|skin(1)	6																		---	---	---	---
NCAPD3	23310	broad.mit.edu	37	11	134086631	134086631	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:134086631delA	uc001qhd.1	-						NCAPD3_uc010scm.1_Intron|NCAPD3_uc009zda.1_Intron	NM_015261	NP_056076			non-SMC condensin II complex, subunit D3						cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	5	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)														---	---	---	---
CCDC77	84318	broad.mit.edu	37	12	518377	518378	+	Intron	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:518377_518378delAA	uc001qig.2	+						CCDC77_uc009zdk.2_Intron|CCDC77_uc010sdp.1_Intron|CCDC77_uc010sdq.1_Intron	NM_032358	NP_115734			coiled-coil domain containing 77 isoform a							centrosome				ovary(1)	1	all_cancers(10;0.0149)|all_epithelial(11;0.035)|all_lung(10;0.111)|Ovarian(42;0.142)|Lung NSC(10;0.156)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.033)															---	---	---	---
DYRK4	8798	broad.mit.edu	37	12	4711468	4711468	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:4711468delT	uc001qmx.2	+						DYRK4_uc009zeh.1_Intron|DYRK4_uc001qmy.1_Intron|DYRK4_uc001qmz.1_5'Flank|DYRK4_uc001qna.1_5'Flank|DYRK4_uc010ser.1_5'Flank	NM_003845	NP_003836			dual-specificity tyrosine-(Y)-phosphorylation							Golgi apparatus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(2)|skin(1)	3			Colorectal(7;0.103)															---	---	---	---
NDUFA9	4704	broad.mit.edu	37	12	4791632	4791632	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:4791632delA	uc001qnc.2	+						NDUFA9_uc010ses.1_Intron	NM_005002	NP_004993			NADH dehydrogenase (ubiquinone) 1 alpha						mitochondrial electron transport, NADH to ubiquinone|sodium ion transport	mitochondrial matrix|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity|protein binding			ovary(1)	1					NADH(DB00157)													---	---	---	---
VWF	7450	broad.mit.edu	37	12	6138254	6138255	+	Intron	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:6138254_6138255delAA	uc001qnn.1	-						VWF_uc010set.1_Intron	NM_000552	NP_000543			von Willebrand factor preproprotein						blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)													---	---	---	---
LTBR	4055	broad.mit.edu	37	12	6497628	6497630	+	In_Frame_Del	DEL	CTC	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:6497628_6497630delCTC	uc001qny.1	+	7	900_902	c.732_734delCTC	c.(730-735)TTCTCC>TTC	p.S245del	LTBR_uc010sfc.1_In_Frame_Del_p.S226del|LTBR_uc001qnz.1_In_Frame_Del_p.S240del	NM_002342	NP_002333	P36941	TNR3_HUMAN	lymphotoxin beta receptor precursor	245	Helical; (Potential).				apoptosis|cellular response to mechanical stimulus|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	protein binding|receptor activity			lung(2)	2																		---	---	---	---
PHB2	11331	broad.mit.edu	37	12	7074883	7074883	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:7074883delA	uc001qsd.2	-						PHB2_uc001qse.1_Intron|PHB2_uc001qsf.1_Intron|PHB2_uc009zfn.1_Intron	NM_001144831	NP_001138303			prohibitin 2 isoform 1						negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial inner membrane|nucleus	estrogen receptor binding|receptor activity			ovary(2)|pancreas(1)	3																OREG0021644	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
CLEC6A	93978	broad.mit.edu	37	12	8613879	8613879	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:8613879delA	uc001qum.1	+							NM_001007033	NP_001007034			dectin-2						defense response to fungus|innate immune response|positive regulation of cytokine secretion|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	sugar binding			breast(1)	1	Lung SC(5;0.184)																	---	---	---	---
LOC642846	642846	broad.mit.edu	37	12	9464826	9464826	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:9464826delC	uc010sgp.1	+							NR_024374				Homo sapiens cDNA FLJ60280 complete cds, highly similar to Probable ATP-dependent RNA helicase DDX11 (EC 3.6.1.-).												0																		---	---	---	---
DDX12	440081	broad.mit.edu	37	12	9595963	9595963	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:9595963delA	uc010sgs.1	-							NM_004400	NP_004391			DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12												0																		---	---	---	---
CLEC2D	29121	broad.mit.edu	37	12	9833434	9833434	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:9833434delA	uc001qwg.1	+						CLEC2D_uc001qwf.1_Intron|CLEC2D_uc009zgs.1_Intron|CLEC2D_uc001qwh.1_Intron|CLEC2D_uc009zgt.1_Intron|CLEC2D_uc009zgu.1_5'Flank	NM_013269	NP_037401			osteoclast inhibitory lectin isoform 1						cell surface receptor linked signaling pathway	cell surface|endoplasmic reticulum|integral to plasma membrane|membrane fraction	sugar binding|transmembrane receptor activity				0																		---	---	---	---
KLRF1	51348	broad.mit.edu	37	12	9994747	9994748	+	Intron	DEL	TG	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:9994747_9994748delTG	uc010sgw.1	+						KLRF1_uc009zgw.2_Intron|KLRF1_uc009zgx.2_Intron|KLRF1_uc001qwm.2_Intron|KLRF1_uc009zgy.2_Intron|KLRF1_uc009zgz.2_Intron|KLRF1_uc009zha.2_Intron	NM_016523	NP_057607			killer cell lectin-like receptor subfamily F,						cell surface receptor linked signaling pathway	integral to plasma membrane	MHC class I receptor activity|sugar binding			large_intestine(1)	1																		---	---	---	---
CLEC12B	387837	broad.mit.edu	37	12	10167705	10167705	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:10167705delT	uc001qwz.2	+						CLEC12B_uc001qwx.1_Intron|CLEC12B_uc001qwy.1_Intron|CLEC12B_uc009zhe.2_Intron	NM_001129998	NP_001123470			C-type lectin domain family 12, member B isoform							integral to membrane|plasma membrane	receptor activity|sugar binding				0																		---	---	---	---
CLEC7A	64581	broad.mit.edu	37	12	10279790	10279790	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:10279790delA	uc001qxg.2	-						CLEC7A_uc001qxe.3_Intron|CLEC7A_uc001qxf.2_Intron|CLEC7A_uc001qxh.2_Intron|CLEC7A_uc001qxi.2_Intron|CLEC7A_uc001qxj.2_Intron|CLEC7A_uc009zhg.1_Intron|CLEC7A_uc001qxk.1_Intron|CLEC7A_uc001qxl.1_Intron|CLEC7A_uc010sgy.1_Intron|CLEC7A_uc001qxm.1_Intron	NM_197947	NP_922938			dendritic cell-associated C-type lectin 1						carbohydrate mediated signaling|defense response to protozoan|inflammatory response|innate immune response|phagocytosis, recognition|T cell activation	cytoplasm|integral to membrane	metal ion binding|MHC protein binding|sugar binding			central_nervous_system(1)	1																		---	---	---	---
STYK1	55359	broad.mit.edu	37	12	10783476	10783476	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:10783476delA	uc001qys.2	-							NM_018423	NP_060893			serine/threonine/tyrosine kinase 1							integral to membrane|plasma membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(3)|ovary(2)|lung(2)|breast(1)	8															HNSCC(73;0.22)			---	---	---	---
HTR7P1	93164	broad.mit.edu	37	12	13155743	13155743	+	RNA	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:13155743delA	uc010shq.1	+	1		c.2368delA			HEBP1_uc001rbd.2_5'Flank|HEBP1_uc001rbf.2_5'Flank|HTR7P1_uc001rbh.2_Intron	NR_002774				Homo sapiens 5-hydroxytryptamine (serotonin) receptor 7 pseudogene (HTR7P), non-coding RNA.												0																		---	---	---	---
PDE6H	5149	broad.mit.edu	37	12	15130881	15130881	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:15130881delT	uc001rcr.2	+							NM_006205	NP_006196			phosphodiesterase 6H						visual perception		3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|enzyme inhibitor activity			ovary(1)|skin(1)	2																		---	---	---	---
PIK3C2G	5288	broad.mit.edu	37	12	18690984	18690984	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:18690984delA	uc001rdt.2	+						PIK3C2G_uc010sia.1_Intron|PIK3C2G_uc010sib.1_Intron|PIK3C2G_uc010sic.1_Intron	NM_004570	NP_004561			phosphoinositide-3-kinase, class 2 gamma						cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)																---	---	---	---
PYROXD1	79912	broad.mit.edu	37	12	21593418	21593419	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:21593418_21593419insA	uc001rew.2	+						PYROXD1_uc009ziq.2_Intron|PYROXD1_uc009zir.2_Intron	NM_024854	NP_079130			pyridine nucleotide-disulphide oxidoreductase								oxidoreductase activity			ovary(1)	1																		---	---	---	---
GYS2	2998	broad.mit.edu	37	12	21715633	21715641	+	Intron	DEL	AAAAAAAAA	-	-	rs144048267		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:21715633_21715641delAAAAAAAAA	uc001rfb.2	-							NM_021957	NP_068776			glycogen synthase 2						glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			lung(1)|skin(1)	2																		---	---	---	---
LDHB	3945	broad.mit.edu	37	12	21794870	21794870	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:21794870delT	uc001rfc.2	-						LDHB_uc001rfd.2_Intron|LDHB_uc001rfe.2_Intron	NM_002300	NP_002291			L-lactate dehydrogenase B						glycolysis|pyruvate metabolic process	cytosol	L-lactate dehydrogenase activity			breast(2)|ovary(1)	3					NADH(DB00157)													---	---	---	---
CMAS	55907	broad.mit.edu	37	12	22211430	22211430	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:22211430delT	uc001rfm.2	+						CMAS_uc001rfn.2_Intron	NM_018686	NP_061156			cytidine monophospho-N-acetylneuraminic acid						lipopolysaccharide biosynthetic process	nucleus	N-acylneuraminate cytidylyltransferase activity			ovary(1)|pancreas(1)|skin(1)	3																		---	---	---	---
KIAA0528	9847	broad.mit.edu	37	12	22659571	22659571	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:22659571delA	uc001rfq.2	-						KIAA0528_uc010sir.1_Intron|KIAA0528_uc010sis.1_Intron|KIAA0528_uc010sit.1_Intron|KIAA0528_uc010siu.1_Intron|KIAA0528_uc001rfr.2_Intron|KIAA0528_uc009ziy.1_Intron	NM_014802	NP_055617			hypothetical protein LOC9847								protein binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4																		---	---	---	---
BCAT1	586	broad.mit.edu	37	12	24989606	24989606	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:24989606delA	uc001rgd.3	-						BCAT1_uc001rgc.2_Intron|BCAT1_uc010six.1_Intron|BCAT1_uc010siy.1_Intron|BCAT1_uc001rge.3_Intron	NM_005504	NP_005495			branched chain aminotransferase 1, cytosolic						branched chain family amino acid biosynthetic process|branched chain family amino acid catabolic process|cell proliferation|G1/S transition of mitotic cell cycle	cytosol	L-isoleucine transaminase activity|L-leucine transaminase activity|L-valine transaminase activity			lung(1)|breast(1)	2	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Ovarian(17;0.107)|Colorectal(261;0.196)				Gabapentin(DB00996)|L-Glutamic Acid(DB00142)|L-Isoleucine(DB00167)|L-Leucine(DB00149)|L-Valine(DB00161)|Pyridoxal Phosphate(DB00114)													---	---	---	---
TM7SF3	51768	broad.mit.edu	37	12	27152717	27152717	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:27152717delA	uc010sjl.1	-							NM_016551	NP_057635			transmembrane 7 superfamily member 3 precursor							integral to membrane|plasma membrane				upper_aerodigestive_tract(2)	2	Colorectal(261;0.0847)																	---	---	---	---
PPFIBP1	8496	broad.mit.edu	37	12	27786283	27786284	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:27786283_27786284insT	uc001ric.1	+						PPFIBP1_uc001rhy.1_Intron|PPFIBP1_uc001rhz.1_Intron|PPFIBP1_uc010sjr.1_Intron|PPFIBP1_uc001rib.1_Intron|PPFIBP1_uc001ria.2_Intron|PPFIBP1_uc001rid.1_Intron	NM_003622	NP_003613			PTPRF interacting protein binding protein 1						cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	soft_tissue(3)|kidney(1)|skin(1)	5	Lung SC(9;0.0873)																	---	---	---	---
TMTC1	83857	broad.mit.edu	37	12	29673736	29673736	+	Intron	DEL	A	-	-	rs113588704		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:29673736delA	uc001rjb.2	-						TMTC1_uc001riz.2_Intron|TMTC1_uc001rja.2_Intron|TMTC1_uc001riy.2_5'Flank	NM_175861	NP_787057			transmembrane and tetratricopeptide repeat							integral to membrane	binding				0	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)																	---	---	---	---
DENND5B	160518	broad.mit.edu	37	12	31648701	31648701	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:31648701delA	uc001rki.1	-						DENND5B_uc001rkh.1_Intron|DENND5B_uc001rkj.2_Intron|DENND5B_uc001rkk.1_Intron	NM_144973	NP_659410			DENN/MADD domain containing 5B							integral to membrane				ovary(1)|central_nervous_system(1)	2																		---	---	---	---
AMN1	196394	broad.mit.edu	37	12	31842162	31842162	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:31842162delA	uc001rkq.3	-						AMN1_uc001rko.3_Intron|AMN1_uc010skc.1_Intron|AMN1_uc001rkp.3_Intron|AMN1_uc009zjs.2_Intron|AMN1_uc009zjt.1_Intron	NM_001113402	NP_001106873			antagonist of mitotic exit network 1 homolog												0	all_cancers(9;7.41e-12)|all_epithelial(9;1.18e-11)|all_lung(12;1.14e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.162)		OV - Ovarian serous cystadenocarcinoma(6;0.0014)															---	---	---	---
ALG10	84920	broad.mit.edu	37	12	34179326	34179326	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:34179326delT	uc001rlm.2	+	3	1217	c.898delT	c.(898-900)TTTfs	p.F300fs		NM_032834	NP_116223	Q5BKT4	AG10A_HUMAN	asparagine-linked glycosylation 10 homolog	300	Helical; (Potential).				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			skin(1)	1	Lung NSC(5;3.82e-05)|Acute lymphoblastic leukemia(23;0.0142)|all_hematologic(23;0.0429)	Lung NSC(34;0.204)|all_lung(34;0.235)																---	---	---	---
CPNE8	144402	broad.mit.edu	37	12	39124250	39124250	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:39124250delA	uc001rls.1	-							NM_153634	NP_705898			copine VIII											pancreas(1)	1	Esophageal squamous(101;0.187)	Lung NSC(34;0.137)|Melanoma(24;0.152)|all_lung(34;0.157)																---	---	---	---
SLC2A13	114134	broad.mit.edu	37	12	40258794	40258794	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:40258794delA	uc010skm.1	-						C12orf40_uc009zjv.1_Intron|SLC2A13_uc001rme.1_Intron	NM_052885	NP_443117			solute carrier family 2 (facilitated glucose							integral to membrane|plasma membrane	myo-inositol:hydrogen symporter activity			ovary(1)	1		Lung NSC(34;0.105)|all_lung(34;0.123)													HNSCC(50;0.14)			---	---	---	---
ADAMTS20	80070	broad.mit.edu	37	12	43826376	43826376	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:43826376delT	uc010skx.1	-						ADAMTS20_uc001rno.1_Intron|ADAMTS20_uc001rnp.1_Intron	NM_025003	NP_079279			a disintegrin-like and metalloprotease with							proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)														---	---	---	---
ADAMTS20	80070	broad.mit.edu	37	12	43886223	43886223	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:43886223delA	uc010skx.1	-							NM_025003	NP_079279			a disintegrin-like and metalloprotease with							proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)														---	---	---	---
SFRS2IP	9169	broad.mit.edu	37	12	46358030	46358030	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:46358030delA	uc001rox.2	-						SFRS2IP_uc001roy.1_Intron|SFRS2IP_uc009zki.1_Intron|SFRS2IP_uc001roz.2_Intron	NM_004719	NP_004710			splicing factor, arginine/serine-rich 2,						spliceosome assembly	nucleus	protein binding|zinc ion binding				0	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.209)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.1)														---	---	---	---
SLC38A1	81539	broad.mit.edu	37	12	46582675	46582677	+	3'UTR	DEL	AAG	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:46582675_46582677delAAG	uc001rpa.2	-	17					SLC38A1_uc001rpb.2_3'UTR|SLC38A1_uc001rpc.2_3'UTR|SLC38A1_uc001rpd.2_3'UTR|SLC38A1_uc001rpe.2_3'UTR	NM_030674	NP_109599			amino acid transporter system A1						cellular nitrogen compound metabolic process|neurotransmitter uptake	integral to membrane|plasma membrane	sodium:amino acid symporter activity			ovary(2)|skin(2)|central_nervous_system(1)	5	Lung SC(27;0.137)|Renal(347;0.236)		all cancers(1;0.00805)|OV - Ovarian serous cystadenocarcinoma(5;0.0106)|Epithelial(2;0.0344)															---	---	---	---
RPAP3	79657	broad.mit.edu	37	12	48073181	48073181	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:48073181delA	uc001rpr.2	-						RPAP3_uc010slk.1_Intron|RPAP3_uc001rps.2_Intron	NM_024604	NP_078880			RNA polymerase II associated protein 3 isoform								binding			ovary(1)	1	Lung SC(27;0.192)																	---	---	---	---
VDR	7421	broad.mit.edu	37	12	48249317	48249317	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:48249317delA	uc001rqm.2	-						VDR_uc001rql.2_Intron|VDR_uc001rqn.2_Intron|VDR_uc010slq.1_Intron	NM_001017535	NP_001017535			vitamin D (1,25-dihydroxyvitamin D3) receptor						decidualization|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of vitamin D 24-hydroxylase activity|regulation of calcidiol 1-monooxygenase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid X receptor binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|vitamin D3 receptor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Acute lymphoblastic leukemia(13;0.109)|all_hematologic(14;0.214)		GBM - Glioblastoma multiforme(48;0.17)	Calcidiol(DB00146)|Calcipotriol(DB02300)|Calcitriol(DB00136)|Dihydrotachysterol(DB01070)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)													---	---	---	---
PRKAG1	5571	broad.mit.edu	37	12	49412460	49412461	+	Intron	INS	-	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49412460_49412461insG	uc001rsy.2	-						uc001rsw.2_3'UTR|PRKAG1_uc010smd.1_5'UTR|PRKAG1_uc001rsx.2_Intron|PRKAG1_uc001rsz.2_Intron|PRKAG1_uc009zlb.2_Intron|PRKAG1_uc010sme.1_Intron	NM_002733	NP_002724			AMP-activated protein kinase, noncatalytic						cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|positive regulation of protein kinase activity|regulation of fatty acid oxidation|regulation of glycolysis|spermatogenesis	cytosol	cAMP-dependent protein kinase activity|cAMP-dependent protein kinase regulator activity|protein kinase binding			kidney(1)	1																		---	---	---	---
DHH	50846	broad.mit.edu	37	12	49487847	49487847	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49487847delT	uc001rtf.2	-							NM_021044	NP_066382			desert hedgehog preproprotein						cell-cell signaling|proteolysis	extracellular space|plasma membrane	calcium ion binding|peptidase activity|zinc ion binding			lung(1)|breast(1)	2																		---	---	---	---
TUBA1A	7846	broad.mit.edu	37	12	49580268	49580268	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49580268delG	uc009zlf.2	-						TUBA1B_uc001rto.2_Intron|TUBA1A_uc001rtp.2_Intron|TUBA1A_uc001rtq.2_Intron|TUBA1A_uc001rtr.2_Intron|TUBA1A_uc009zlg.2_Intron	NM_006009	NP_006000			tubulin, alpha 1a						'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|structural molecule activity				0																		---	---	---	---
KCNH3	23416	broad.mit.edu	37	12	49943832	49943832	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49943832delC	uc001ruh.1	+						KCNH3_uc010smj.1_Intron	NM_012284	NP_036416			potassium voltage-gated channel, subfamily H						regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity				0																		---	---	---	---
FAM186B	84070	broad.mit.edu	37	12	49989085	49989085	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49989085delA	uc001ruo.2	-						FAM186B_uc010smk.1_Intron	NM_032130	NP_115506			hypothetical protein LOC84070							protein complex				ovary(1)	1																		---	---	---	---
ACCN2	41	broad.mit.edu	37	12	50473914	50473914	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:50473914delG	uc001rvw.2	+						ACCN2_uc001rvv.2_Intron|ACCN2_uc009zln.2_Intron|ACCN2_uc009zlo.2_Intron	NM_001095	NP_001086			amiloride-sensitive cation channel 2, neuronal						calcium ion transport|response to pH|signal transduction	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(1)	1					Amiloride(DB00594)													---	---	---	---
BIN2	51411	broad.mit.edu	37	12	51686210	51686210	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:51686210delA	uc001ryg.2	-						BIN2_uc009zlz.2_Intron|BIN2_uc001ryh.2_Intron|BIN2_uc010sng.1_Intron	NM_016293	NP_057377			bridging integrator 2							cytoplasm	protein binding			ovary(1)	1																		---	---	---	---
SLC4A8	9498	broad.mit.edu	37	12	51854858	51854859	+	Intron	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:51854858_51854859delTT	uc001rys.1	+						SLC4A8_uc010sni.1_Intron|SLC4A8_uc001rym.2_Intron|SLC4A8_uc001ryn.2_Intron|SLC4A8_uc001ryo.2_Intron|SLC4A8_uc001ryp.1_Intron|SLC4A8_uc010snj.1_Intron|SLC4A8_uc001ryq.3_Intron|SLC4A8_uc001ryr.2_Intron|SLC4A8_uc010snk.1_Intron	NM_001039960	NP_001035049			solute carrier family 4, sodium bicarbonate						bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			ovary(3)|pancreas(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.15)														---	---	---	---
KRT82	3888	broad.mit.edu	37	12	52797240	52797241	+	Intron	INS	-	AG	AG			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:52797240_52797241insAG	uc001sai.1	-							NM_033033	NP_149022			keratin 82							keratin filament	protein binding|structural constituent of epidermis			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.193)														---	---	---	---
KRT3	3850	broad.mit.edu	37	12	53188985	53188986	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:53188985_53188986insT	uc001say.2	-							NM_057088	NP_476429			keratin 3						epithelial cell differentiation|intermediate filament cytoskeleton organization	keratin filament	structural molecule activity				0																		---	---	---	---
KRT8	3856	broad.mit.edu	37	12	53292788	53292788	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:53292788delC	uc001sbd.2	-						KRT8_uc009zmj.2_Intron|KRT8_uc009zmk.1_Intron|KRT8_uc009zml.1_Intron|KRT8_uc009zmm.1_Intron	NM_002273	NP_002264			keratin 8						cytoskeleton organization|interspecies interaction between organisms	cytoplasm|keratin filament|nuclear matrix|nucleoplasm	protein binding|structural molecule activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.108)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
COPZ1	22818	broad.mit.edu	37	12	54739315	54739315	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:54739315delT	uc001sfs.1	+						COPZ1_uc001sft.2_Intron|COPZ1_uc009znm.1_Intron|COPZ1_uc010sot.1_Intron	NM_016057	NP_057141			coatomer protein complex, subunit zeta 1						COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol					0																		---	---	---	---
GTSF1	121355	broad.mit.edu	37	12	54859084	54859084	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:54859084delA	uc001sgb.2	-							NM_144594	NP_653195			gametocyte specific factor 1								metal ion binding				0		Myeloproliferative disorder(1001;0.00452)																---	---	---	---
DCD	117159	broad.mit.edu	37	12	55038760	55038760	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:55038760delA	uc001sgj.2	-						DCD_uc009znt.2_Intron|DCD_uc009znu.2_Intron	NM_053283	NP_444513			dermcidin preproprotein						defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular region	protein binding			ovary(1)	1		Myeloproliferative disorder(1001;0.0255)																---	---	---	---
OR6C74	254783	broad.mit.edu	37	12	55641767	55641767	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:55641767delA	uc010spg.1	+	1	696	c.696delA	c.(694-696)AGAfs	p.R232fs		NM_001005490	NP_001005490	A6NCV1	O6C74_HUMAN	olfactory receptor, family 6, subfamily C,	232	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	12	55771206	55771206	+	IGR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:55771206delA								OR6C75 (11374 upstream) : OR6C65 (23107 downstream)																																			---	---	---	---
ERBB3	2065	broad.mit.edu	37	12	56492761	56492762	+	Intron	DEL	AG	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56492761_56492762delAG	uc001sjh.2	+						ERBB3_uc009zoj.2_Intron|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Intron|ERBB3_uc009zok.2_Intron|ERBB3_uc001sjk.2_Intron|ERBB3_uc001sjl.2_Intron	NM_001982	NP_001973			erbB-3 isoform 1 precursor						cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)															---	---	---	---
RPL41	6171	broad.mit.edu	37	12	56510923	56510929	+	Intron	DEL	TTTTTTT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56510923_56510929delTTTTTTT	uc001sjn.2	+						RPL41_uc001sjo.2_Intron|ZC3H10_uc001sjp.1_5'Flank	NM_021104				ribosomal protein L41						endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0			OV - Ovarian serous cystadenocarcinoma(18;0.12)															---	---	---	---
ANKRD52	283373	broad.mit.edu	37	12	56639080	56639081	+	Intron	INS	-	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56639080_56639081insC	uc001skm.3	-							NM_173595	NP_775866			ankyrin repeat domain 52								protein binding			ovary(2)	2																		---	---	---	---
STAC3	246329	broad.mit.edu	37	12	57639159	57639161	+	Intron	DEL	TTT	-	-	rs77875185		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57639159_57639161delTTT	uc001snp.2	-						STAC3_uc009zpl.2_Intron|STAC3_uc001snq.2_Intron|STAC3_uc010srm.1_Intron	NM_145064	NP_659501			SH3 and cysteine rich domain 3						intracellular signal transduction		identical protein binding|metal ion binding			ovary(2)|skin(1)	3																		---	---	---	---
OS9	10956	broad.mit.edu	37	12	58113738	58113738	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:58113738delT	uc001spj.2	+						OS9_uc010srx.1_Intron|OS9_uc001spk.2_Intron|OS9_uc001spl.2_Intron|OS9_uc001spm.2_Intron|OS9_uc001spn.2_Intron|OS9_uc010sry.1_Intron|OS9_uc010srz.1_Intron	NM_006812	NP_006803			osteosarcoma amplified 9, endoplasmic reticulum						ER-associated protein catabolic process|protein retention in ER lumen|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to endoplasmic reticulum stress	endoplasmic reticulum lumen|Hrd1p ubiquitin ligase complex	glycoprotein binding|protein binding|sugar binding			ovary(1)	1	all_neural(12;0.00548)|Glioma(12;0.0126)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)															---	---	---	---
XPOT	11260	broad.mit.edu	37	12	64825692	64825692	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:64825692delT	uc001ssb.2	+							NM_007235	NP_009166			tRNA exportin						intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(28;0.0404)														---	---	---	---
HMGA2	8091	broad.mit.edu	37	12	66221759	66221759	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:66221759delT	uc001ssx.2	+						RPSAP52_uc001sso.2_5'Flank|HMGA2_uc001ssw.1_Intron|HMGA2_uc001ssp.1_Intron|HMGA2_uc010ssv.1_Intron|HMGA2_uc001sss.1_Intron|HMGA2_uc001sst.1_Intron|HMGA2_uc001ssu.1_Intron|HMGA2_uc001ssv.2_Intron	NM_003483	NP_003474			high mobility group AT-hook 2 isoform a						cell division|chromatin organization|mitosis|multicellular organismal development|regulation of growth|transcription, DNA-dependent	chromatin	AT DNA binding		HMGA2/LPP(161)|HMGA2/WIF1_ENST00000286574(14)|HMGA2/RAD51B(11)|HMGA2/NFIB_ENST00000397581(8)|HMGA2/FHIT_ENST00000476844(4)|HMGA2/CCNB1IP1(2)|HMGA2/ALDH2_ENST00000261733(2)|HMGA2/EBF1(2)|HMGA2/LHFP(2)|HMGA2/COX6C(2)	soft_tissue(159)|bone(27)|salivary_gland(22)	208	all_cancers(1;5.78e-46)		GBM - Glioblastoma multiforme(1;0.00179)|LUSC - Lung squamous cell carcinoma(43;0.156)	GBM - Glioblastoma multiforme(28;0.0386)				T	 LHFP|RAD51L1|LPP|HEI10|COX6C|CMKOR1|NFIB|ALDH2|CCNB1IP1|EBF1|WIF1|FHIT	lipoma|leiomyoma|pleiomorphic salivary gland adenoma								---	---	---	---
TMBIM4	51643	broad.mit.edu	37	12	66545941	66545941	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:66545941delA	uc001stc.2	-						LLPH_uc010ssx.1_Intron|TMBIM4_uc001std.2_Intron|TMBIM4_uc009zqr.2_Intron|TMBIM4_uc001ste.2_Intron|TMBIM4_uc001stf.2_Intron|TMBIM4_uc009zqs.2_Intron	NM_016056	NP_057140			transmembrane BAX inhibitor motif containing 4							integral to membrane	protein binding			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(28;0.0745)														---	---	---	---
GRIP1	23426	broad.mit.edu	37	12	66909107	66909107	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:66909107delA	uc001stk.2	-						GRIP1_uc010sta.1_Intron|GRIP1_uc001stl.1_Intron|GRIP1_uc001stm.2_Intron	NM_021150	NP_066973			glutamate receptor interacting protein 1						androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			ovary(2)	2			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)														---	---	---	---
NUP107	57122	broad.mit.edu	37	12	69103190	69103190	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:69103190delT	uc001suf.2	+						NUP107_uc001sug.2_Intron|NUP107_uc010stj.1_Intron	NM_020401	NP_065134			nucleoporin 107kDa						carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			skin(1)	1	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)															---	---	---	---
MDM2	4193	broad.mit.edu	37	12	69229771	69229771	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:69229771delT	uc001sui.2	+						MDM2_uc009zri.2_Intron|MDM2_uc009zqx.2_Intron|MDM2_uc009zqw.2_Intron|MDM2_uc001suk.2_Intron|MDM2_uc001sun.3_Intron|MDM2_uc009zqz.2_Intron|MDM2_uc009zra.2_Intron|MDM2_uc001sum.1_Intron|MDM2_uc009zrd.2_Intron|MDM2_uc009zrc.2_Intron|MDM2_uc009zre.2_Intron|MDM2_uc009zrf.2_Intron|MDM2_uc001suo.2_Intron|MDM2_uc009zrg.2_Intron|MDM2_uc009zrh.2_Intron	NM_002392	NP_002383			mouse double minute 2 homolog isoform MDM2						cellular response to hypoxia|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|establishment of protein localization|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell cycle arrest|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein complex assembly|protein destabilization|protein localization to nucleus|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to antibiotic|synaptic transmission	cytosol|endocytic vesicle membrane|insoluble fraction|nucleolus|nucleoplasm|plasma membrane|protein complex	enzyme binding|identical protein binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|central_nervous_system(1)	3	all_cancers(1;8.46e-121)|all_epithelial(5;3.21e-36)|Lung NSC(4;2.16e-33)|all_lung(4;3.03e-31)|Glioma(1;1.9e-09)|Breast(13;1.59e-06)|all_neural(1;1.03e-05)|Melanoma(1;0.0171)|Renal(347;0.0684)		all cancers(2;8.67e-65)|GBM - Glioblastoma multiforme(2;8.89e-62)|BRCA - Breast invasive adenocarcinoma(5;2.43e-08)|Lung(24;1.5e-05)|LUAD - Lung adenocarcinoma(15;8.5e-05)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)					A		sarcoma|glioma|colorectal|other								---	---	---	---
LYZ	4069	broad.mit.edu	37	12	69744010	69744010	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:69744010delA	uc001suw.2	+	2	314	c.259delA	c.(259-261)AAAfs	p.K87fs		NM_000239	NP_000230	P61626	LYSC_HUMAN	lysozyme precursor	87					cell wall macromolecule catabolic process|cytolysis|defense response to bacterium|inflammatory response	extracellular space	lysozyme activity|protein binding				0	all_epithelial(5;2.98e-35)|Lung NSC(4;9.93e-33)|all_lung(4;5.66e-31)|Breast(13;2.56e-06)|Esophageal squamous(21;0.187)		Epithelial(6;8.26e-19)|BRCA - Breast invasive adenocarcinoma(5;8.5e-10)|Lung(24;9.68e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00503)|OV - Ovarian serous cystadenocarcinoma(12;0.00691)|LUSC - Lung squamous cell carcinoma(43;0.24)|Kidney(9;0.241)															---	---	---	---
CNOT2	4848	broad.mit.edu	37	12	70739865	70739865	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:70739865delT	uc001svv.2	+						CNOT2_uc009zro.2_Intron|CNOT2_uc009zrp.2_Intron|CNOT2_uc009zrq.2_Intron	NM_014515	NP_055330			CCR4-NOT transcription complex, subunit 2						nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	protein binding|RNA polymerase II transcription cofactor activity				0	Renal(347;0.236)		GBM - Glioblastoma multiforme(1;4.77e-09)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00243)|STAD - Stomach adenocarcinoma(21;0.0118)															---	---	---	---
RAB21	23011	broad.mit.edu	37	12	72176339	72176339	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:72176339delT	uc001swt.2	+							NM_014999	NP_055814			RAB21, member RAS oncogene family						protein transport|small GTPase mediated signal transduction	cleavage furrow|cytoplasmic vesicle membrane|early endosome membrane|endoplasmic reticulum membrane|Golgi membrane	GDP binding|GTP binding|GTPase activity|protein binding				0																		---	---	---	---
CAPS2	84698	broad.mit.edu	37	12	75693815	75693815	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:75693815delA	uc001sxk.3	-						CAPS2_uc001sxm.3_Intron|CAPS2_uc009zsa.2_Intron|CAPS2_uc001sxi.3_Intron|CAPS2_uc001sxj.3_Intron|CAPS2_uc001sxl.3_Intron	NM_032606	NP_115995			calcyphosine 2								calcium ion binding			ovary(2)	2																		---	---	---	---
KRR1	11103	broad.mit.edu	37	12	75893593	75893593	+	Frame_Shift_Del	DEL	T	-	-	rs140273898	byFrequency	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:75893593delT	uc001sxt.2	-	10	1183	c.1142delA	c.(1141-1143)AAGfs	p.K381fs	GLIPR1_uc001sxs.2_3'UTR|KRR1_uc009zsc.2_Frame_Shift_Del_p.K324fs	NM_007043	NP_008974	Q13601	KRR1_HUMAN	HIV-1 rev binding protein 2	381	Lys-rich.				rRNA processing	nucleolus|ribonucleoprotein complex	RNA binding			ovary(1)|pancreas(1)	2																		---	---	---	---
NAP1L1	4673	broad.mit.edu	37	12	76468043	76468043	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:76468043delA	uc001sxw.2	-						NAP1L1_uc001sxz.2_Intron|NAP1L1_uc001sxx.2_Intron|NAP1L1_uc001sxy.2_Intron|NAP1L1_uc010sty.1_Intron|NAP1L1_uc010stz.1_Intron|NAP1L1_uc010sua.1_Intron|NAP1L1_uc001syb.2_Intron|NAP1L1_uc001sya.2_Intron|NAP1L1_uc001syc.2_Intron	NM_139207	NP_631946			nucleosome assembly protein 1-like 1						DNA replication|nucleosome assembly|positive regulation of cell proliferation	chromatin assembly complex|melanosome	protein binding			ovary(1)|skin(1)	2		Colorectal(145;0.09)																---	---	---	---
NAV3	89795	broad.mit.edu	37	12	78334768	78334768	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:78334768delT	uc001syp.2	+						NAV3_uc001syo.2_Intron	NM_014903	NP_055718			neuron navigator 3							nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17															HNSCC(70;0.22)			---	---	---	---
NAV3	89795	broad.mit.edu	37	12	78594419	78594419	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:78594419delA	uc001syp.2	+						NAV3_uc001syo.2_Intron|NAV3_uc010sub.1_Intron|NAV3_uc009zsf.2_Intron	NM_014903	NP_055718			neuron navigator 3							nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17															HNSCC(70;0.22)			---	---	---	---
Unknown	0	broad.mit.edu	37	12	80730562	80730562	+	IGR	DEL	T	-	-	rs11300714		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:80730562delT								PPP1R12A (401327 upstream) : PTPRQ (107564 downstream)																																			---	---	---	---
LIN7A	8825	broad.mit.edu	37	12	81283156	81283156	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:81283156delA	uc001szj.1	-						LIN7A_uc001szk.1_Intron	NM_004664	NP_004655			lin-7 homolog A						exocytosis|protein complex assembly|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	L27 domain binding			ovary(1)|skin(1)	2																		---	---	---	---
PPFIA2	8499	broad.mit.edu	37	12	81839361	81839364	+	Frame_Shift_Del	DEL	CAAA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:81839361_81839364delCAAA	uc001szo.1	-	6	702_705	c.541_544delTTTG	c.(541-546)TTTGAGfs	p.F181fs	PPFIA2_uc010sue.1_Frame_Shift_Del_p.F81fs|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	107_108										ovary(3)|lung(2)|pancreas(1)	6																		---	---	---	---
TMTC2	160335	broad.mit.edu	37	12	83424451	83424451	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:83424451delA	uc001szt.2	+						TMTC2_uc010suk.1_Intron	NM_152588	NP_689801			transmembrane and tetratricopeptide repeat							endoplasmic reticulum|integral to membrane	binding			ovary(2)	2																		---	---	---	---
CEP290	80184	broad.mit.edu	37	12	88448067	88448067	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:88448067delT	uc001tar.2	-						CEP290_uc001taq.2_Intron|uc001tas.2_5'Flank	NM_025114	NP_079390			centrosomal protein 290kDa						cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			ovary(5)|breast(1)|pancreas(1)	7																		---	---	---	---
CEP290	80184	broad.mit.edu	37	12	88502987	88502987	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:88502987delA	uc001tar.2	-						CEP290_uc001tat.2_Intron	NM_025114	NP_079390			centrosomal protein 290kDa						cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			ovary(5)|breast(1)|pancreas(1)	7																		---	---	---	---
KITLG	4254	broad.mit.edu	37	12	88926063	88926063	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:88926063delA	uc001tav.2	-						KITLG_uc001taw.2_Intron|KITLG_uc009zso.1_Intron	NM_000899	NP_000890			KIT ligand isoform b precursor						cell adhesion|cell proliferation|hemopoiesis|male gonad development|positive regulation of DNA replication|signal transduction	cytoplasm|cytoskeleton|integral to membrane|plasma membrane	growth factor activity|identical protein binding|stem cell factor receptor binding			ovary(1)	1														Testicular_Cancer_Familial_Clustering_of				---	---	---	---
DCN	1634	broad.mit.edu	37	12	91540101	91540101	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:91540101delT	uc001tbs.2	-						DCN_uc001tbo.2_Intron|DCN_uc001tbp.2_Intron|DCN_uc001tbq.2_Intron|DCN_uc001tbr.2_Intron|DCN_uc001tbt.2_Intron|DCN_uc001tbu.2_Intron	NM_133503	NP_598010			decorin isoform a preproprotein						organ morphogenesis	extracellular space				central_nervous_system(2)|ovary(1)|lung(1)	4																		---	---	---	---
EEA1	8411	broad.mit.edu	37	12	93192931	93192931	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:93192931delA	uc001tck.2	-							NM_003566	NP_003557			early endosome antigen 1, 162kD						early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			ovary(2)|skin(1)	3																		---	---	---	---
EEA1	8411	broad.mit.edu	37	12	93195481	93195481	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:93195481delA	uc001tck.2	-							NM_003566	NP_003557			early endosome antigen 1, 162kD						early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			ovary(2)|skin(1)	3																		---	---	---	---
EEA1	8411	broad.mit.edu	37	12	93251373	93251373	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:93251373delA	uc001tck.2	-							NM_003566	NP_003557			early endosome antigen 1, 162kD						early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			ovary(2)|skin(1)	3																		---	---	---	---
NR2C1	7181	broad.mit.edu	37	12	95422409	95422410	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:95422409_95422410insT	uc001tdm.3	-						NR2C1_uc010suu.1_Intron	NM_003297	NP_003288			nuclear receptor subfamily 2, group C, member 1						regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	PML body	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1																		---	---	---	---
SNRPF	6636	broad.mit.edu	37	12	96259866	96259866	+	3'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:96259866delT	uc001tej.2	+	4						NM_003095	NP_003086			small nuclear ribonucleoprotein polypeptide F						histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	protein binding|RNA binding				0																		---	---	---	---
CCDC38	120935	broad.mit.edu	37	12	96284755	96284755	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:96284755delA	uc001tek.1	-							NM_182496	NP_872302			coiled-coil domain containing 38											skin(1)	1																		---	---	---	---
LTA4H	4048	broad.mit.edu	37	12	96407086	96407086	+	Intron	DEL	A	-	-	rs12319438	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:96407086delA	uc001ten.1	-						LTA4H_uc010suy.1_Intron|LTA4H_uc010suz.1_Intron|LTA4H_uc010sva.1_Intron|LTA4H_uc009ztj.2_Intron	NM_000895	NP_000886			leukotriene A4 hydrolase						hormone biosynthetic process|inflammatory response|leukotriene biosynthetic process|peptide catabolic process|prostanoid metabolic process|proteolysis	cytosol|nucleus	aminopeptidase activity|epoxide hydrolase activity|leukotriene-A4 hydrolase activity|metallopeptidase activity|protein binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)	1																		---	---	---	---
CDK17	5128	broad.mit.edu	37	12	96691710	96691714	+	Intron	DEL	AAAAA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:96691710_96691714delAAAAA	uc001tep.1	-						CDK17_uc009ztk.2_Intron|CDK17_uc010svb.1_Intron	NM_002595	NP_002586			PCTAIRE protein kinase 2								ATP binding|cyclin-dependent protein kinase activity			ovary(3)|lung(2)|kidney(1)|central_nervous_system(1)	7																		---	---	---	---
C12orf63	374467	broad.mit.edu	37	12	97082938	97082939	+	Intron	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:97082938_97082939delTT	uc001tet.1	+							NM_198520	NP_940922			hypothetical protein LOC374467											skin(6)|ovary(1)	7																		---	---	---	---
IKBIP	121457	broad.mit.edu	37	12	99008211	99008211	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:99008211delT	uc001tfv.2	-						IKBIP_uc001tfw.2_Intron	NM_201612	NP_963906			IKK interacting protein isoform 2						induction of apoptosis|response to X-ray	endoplasmic reticulum membrane|integral to membrane	protein binding				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	12	100402758	100402758	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:100402758delT								ANKS1B (24326 upstream) : UHRF1BP1L (28107 downstream)																																			---	---	---	---
ACTR6	64431	broad.mit.edu	37	12	100606439	100606439	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:100606439delA	uc001thb.1	+						ACTR6_uc001thc.1_Intron|ACTR6_uc001thd.1_Intron|ACTR6_uc009ztu.1_Intron|ACTR6_uc001the.1_Intron|ACTR6_uc001thf.1_Intron|uc001thg.1_Intron	NM_022496	NP_071941			ARP6 actin-related protein 6 homolog							cytoplasm|cytoskeleton				ovary(1)	1																		---	---	---	---
DEPDC4	120863	broad.mit.edu	37	12	100649780	100649781	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:100649780_100649781insA	uc001thi.2	-						DEPDC4_uc001thh.1_Intron|DEPDC4_uc001thj.1_Intron|DEPDC4_uc009ztv.1_Intron|DEPDC4_uc001thk.1_Intron|DEPDC4_uc001thl.1_Intron	NM_152317	NP_689530			DEP domain containing 4						intracellular signal transduction						0																		---	---	---	---
DEPDC4	120863	broad.mit.edu	37	12	100657163	100657163	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:100657163delT	uc001thi.2	-						DEPDC4_uc001thh.1_Intron|DEPDC4_uc001thj.1_Intron|DEPDC4_uc009ztv.1_Intron|DEPDC4_uc001thk.1_Intron|DEPDC4_uc001thl.1_Intron	NM_152317	NP_689530			DEP domain containing 4						intracellular signal transduction						0																		---	---	---	---
SLC17A8	246213	broad.mit.edu	37	12	100774908	100774915	+	Intron	DEL	CATCTCAG	-	-	rs68046331		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:100774908_100774915delCATCTCAG	uc010svi.1	+						SLC17A8_uc009ztx.2_Intron	NM_139319	NP_647480			solute carrier family 17 (sodium-dependent						neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)	3																		---	---	---	---
CCDC53	51019	broad.mit.edu	37	12	102406982	102406983	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:102406982_102406983insA	uc010svw.1	-						CCDC53_uc010svx.1_Intron|CCDC53_uc010svy.1_Intron|CCDC53_uc010svz.1_Intron	NM_016053	NP_057137			coiled-coil domain containing 53							WASH complex	protein binding				0																		---	---	---	---
IGF1	3479	broad.mit.edu	37	12	102811349	102811350	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:102811349_102811350insT	uc001tjm.2	-						IGF1_uc001tjn.2_Intron|IGF1_uc001tjo.2_Intron	NM_001111283	NP_001104753			insulin-like growth factor 1 isoform 1						anti-apoptosis|bone mineralization involved in bone maturation|cellular component movement|DNA replication|glycolate metabolic process|muscle hypertrophy|myoblast differentiation|myoblast proliferation|myotube cell development|negative regulation of smooth muscle cell apoptosis|phosphatidylinositol-mediated signaling|platelet activation|platelet degranulation|positive regulation of activated T cell proliferation|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|positive regulation of fibroblast proliferation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis|positive regulation of osteoblast differentiation|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of Ras protein signal transduction|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tyrosine phosphorylation of Stat5 protein|Ras protein signal transduction|regulation of multicellular organism growth|satellite cell maintenance involved in skeletal muscle regeneration	platelet alpha granule lumen	growth factor activity|hormone activity|insulin receptor binding|insulin-like growth factor receptor binding|integrin binding			central_nervous_system(1)|pancreas(1)	2																		---	---	---	---
C12orf42	374470	broad.mit.edu	37	12	103696459	103696462	+	Intron	DEL	AAAA	-	-	rs74761823		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:103696459_103696462delAAAA	uc001tjt.2	-						C12orf42_uc001tjs.2_Intron|C12orf42_uc009zuf.1_Intron|C12orf42_uc001tju.2_Intron	NM_198521	NP_940923			hypothetical protein LOC374470											ovary(1)|central_nervous_system(1)	2																		---	---	---	---
NT5DC3	51559	broad.mit.edu	37	12	104171949	104171949	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:104171949delA	uc010swe.1	-						NT5DC3_uc010swd.1_5'Flank	NM_001031701	NP_001026871			5'-nucleotidase domain containing 3								hydrolase activity|metal ion binding			ovary(2)|skin(1)	3																		---	---	---	---
NFYB	4801	broad.mit.edu	37	12	104519628	104519641	+	Intron	DEL	AAAAAAAAAAAAAA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:104519628_104519641delAAAAAAAAAAAAAA	uc001tkl.1	-						NFYB_uc001tkk.1_Intron	NM_006166	NP_006157			nuclear transcription factor Y, beta							CCAAT-binding factor complex	repressing transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)	1																		---	---	---	---
KIAA1033	23325	broad.mit.edu	37	12	105540512	105540513	+	Intron	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:105540512_105540513delTT	uc001tld.2	+						KIAA1033_uc010swr.1_Intron|KIAA1033_uc010sws.1_Intron	NM_015275	NP_056090			hypothetical protein LOC23325						endosome transport	WASH complex				kidney(1)|central_nervous_system(1)	2																		---	---	---	---
KIAA1033	23325	broad.mit.edu	37	12	105553918	105553918	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:105553918delC	uc001tld.2	+	29	3139	c.3052delC	c.(3052-3054)CCCfs	p.P1018fs	KIAA1033_uc010swr.1_Frame_Shift_Del_p.P1019fs|KIAA1033_uc010sws.1_Frame_Shift_Del_p.P830fs	NM_015275	NP_056090	Q2M389	WAHS7_HUMAN	hypothetical protein LOC23325	1018					endosome transport	WASH complex				kidney(1)|central_nervous_system(1)	2																		---	---	---	---
APPL2	55198	broad.mit.edu	37	12	105583943	105583943	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:105583943delA	uc001tlf.1	-						APPL2_uc010swt.1_Intron|APPL2_uc001tlg.1_Intron|APPL2_uc010swu.1_Intron|APPL2_uc009zuq.2_Intron	NM_018171	NP_060641			adaptor protein, phosphotyrosine interaction, PH						cell cycle|cell proliferation|signal transduction	early endosome membrane|nucleus	protein binding			upper_aerodigestive_tract(1)	1																		---	---	---	---
RFX4	5992	broad.mit.edu	37	12	106977064	106977064	+	5'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:106977064delT	uc001tlr.2	+	1						NM_213594	NP_998759			regulatory factor X4 isoform c						transcription, DNA-dependent	nucleus	DNA binding			upper_aerodigestive_tract(1)	1																		---	---	---	---
C12orf23	90488	broad.mit.edu	37	12	107361045	107361045	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:107361045delT	uc001tmb.2	+						C12orf23_uc001tmc.2_Intron|C12orf23_uc001tmd.2_Intron	NM_152261	NP_689474			hypothetical protein LOC90488							integral to membrane					0																		---	---	---	---
ASCL4	121549	broad.mit.edu	37	12	108169097	108169097	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:108169097delC	uc001tmr.2	+	1	936	c.105delC	c.(103-105)GACfs	p.D35fs		NM_203436	NP_982260	Q6XD76	ASCL4_HUMAN	achaete-scute complex-like 4	34					regulation of transcription from RNA polymerase II promoter|skin development|transcription, DNA-dependent	nucleus	DNA binding			central_nervous_system(1)	1																		---	---	---	---
ISCU	23479	broad.mit.edu	37	12	108960896	108960896	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:108960896delT	uc010sxc.1	+						ISCU_uc010sxa.1_Intron|ISCU_uc010sxb.1_Intron|ISCU_uc001tnc.3_Intron|ISCU_uc009zuy.2_Intron|ISCU_uc010sxd.1_Intron	NM_213595	NP_998760			iron-sulfur cluster assembly enzyme isoform						iron-sulfur cluster assembly|nitrogen fixation	cytosol|mitochondrion|nucleus	iron ion binding|iron-sulfur cluster binding|protein complex scaffold				0																		---	---	---	---
MYO1H	283446	broad.mit.edu	37	12	109838879	109838879	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:109838879delT	uc010sxn.1	+							NM_001101421	NP_001094891			myosin 1H							myosin complex	motor activity				0																		---	---	---	---
GIT2	9815	broad.mit.edu	37	12	110403696	110403696	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:110403696delA	uc001tps.2	-						GIT2_uc001tpq.2_Intron|GIT2_uc001tpv.2_Intron|GIT2_uc001tpu.2_Intron|GIT2_uc001tpt.2_Intron|GIT2_uc010sxu.1_Intron|GIT2_uc001tpw.2_Intron|GIT2_uc010sxv.1_Intron	NM_057169	NP_476510			G protein-coupled receptor kinase interacting						regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	nucleoplasm	ARF GTPase activator activity|protein binding|zinc ion binding			central_nervous_system(1)	1																		---	---	---	---
ARPC3	10094	broad.mit.edu	37	12	110878360	110878360	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:110878360delT	uc001tqq.2	-							NM_005719	NP_005710			actin related protein 2/3 complex subunit 3						cellular component movement|regulation of actin filament polymerization	Arp2/3 protein complex|cytoplasm	actin binding|structural constituent of cytoskeleton			ovary(1)	1																		---	---	---	---
TCTN1	79600	broad.mit.edu	37	12	111066555	111066555	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:111066555delT	uc009zvs.2	+						TCTN1_uc010syb.1_Intron|TCTN1_uc009zvr.1_Intron|TCTN1_uc001trl.2_Intron|TCTN1_uc001trm.2_Intron|TCTN1_uc010syc.1_Intron|TCTN1_uc001tro.2_Intron|TCTN1_uc001trp.3_Intron|TCTN1_uc001trn.3_Intron|TCTN1_uc001tri.2_Intron|TCTN1_uc001trj.1_Intron|TCTN1_uc001trk.3_Intron|HVCN1_uc001trq.1_Intron	NM_001082537	NP_001076006			tectonic family member 1 isoform 2						multicellular organismal development	extracellular region					0																		---	---	---	---
Unknown	0	broad.mit.edu	37	12	111820000	111820001	+	IGR	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:111820000_111820001insA								FAM109A (13075 upstream) : SH2B3 (23751 downstream)																																			---	---	---	---
BRAP	8315	broad.mit.edu	37	12	112117150	112117150	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:112117150delA	uc001tsn.3	-						BRAP_uc010syh.1_Intron|BRAP_uc009zvv.2_Intron	NM_006768	NP_006759			BRCA1 associated protein						MAPKKK cascade|negative regulation of signal transduction|Ras protein signal transduction	cytoplasm|ubiquitin ligase complex	identical protein binding|nuclear localization sequence binding|nucleotide binding|ubiquitin-protein ligase activity|zinc ion binding			lung(1)	1																		---	---	---	---
TPCN1	53373	broad.mit.edu	37	12	113698206	113698206	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:113698206delC	uc001tuw.2	+	3	443	c.146delC	c.(145-147)GCCfs	p.A49fs	TPCN1_uc001tux.2_Frame_Shift_Del_p.A121fs|TPCN1_uc010syt.1_5'UTR	NM_017901	NP_060371	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1 isoform 2	49	Cytoplasmic (Potential).					endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			skin(2)|ovary(1)	3																		---	---	---	---
TBX3	6926	broad.mit.edu	37	12	115121113	115121113	+	5'UTR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:115121113delA	uc001tvt.1	-	1					TBX3_uc001tvu.1_5'UTR|TBX3_uc010syw.1_5'UTR	NM_016569	NP_057653			T-box 3 protein isoform 2						anterior/posterior axis specification, embryo|anti-apoptosis|cell aging|embryonic arm morphogenesis|embryonic digit morphogenesis|female genitalia development|follicle-stimulating hormone secretion|luteinizing hormone secretion|male genitalia development|mesoderm morphogenesis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter|skeletal system development	nucleus	sequence-specific DNA binding			ovary(2)|skin(1)	3	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0574)												OREG0022153	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
MED13L	23389	broad.mit.edu	37	12	116406919	116406919	+	Intron	DEL	A	-	-	rs35517594		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:116406919delA	uc001tvw.2	-							NM_015335	NP_056150			mediator complex subunit 13-like						regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)														---	---	---	---
FBXW8	26259	broad.mit.edu	37	12	117383019	117383019	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:117383019delT	uc001twg.1	+						FBXW8_uc001twf.1_Intron|FBXW8_uc009zwp.1_Intron	NM_153348	NP_699179			F-box and WD repeat domain containing 8 isoform								protein binding			ovary(2)|pancreas(1)	3	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0353)														---	---	---	---
FBXO21	23014	broad.mit.edu	37	12	117603476	117603477	+	Intron	DEL	CT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:117603476_117603477delCT	uc001twk.2	-						FBXO21_uc001twj.2_Intron|FBXO21_uc009zwq.2_Intron|FBXO21_uc001twl.1_Intron	NM_033624	NP_296373			F-box only protein 21 isoform 1						ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			kidney(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0291)														---	---	---	---
FBXO21	23014	broad.mit.edu	37	12	117611951	117611951	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:117611951delA	uc001twk.2	-						FBXO21_uc001twj.2_Intron|FBXO21_uc009zwq.2_Intron	NM_033624	NP_296373			F-box only protein 21 isoform 1						ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			kidney(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0291)														---	---	---	---
FBXO21	23014	broad.mit.edu	37	12	117612801	117612801	+	Intron	DEL	A	-	-	rs138433024		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:117612801delA	uc001twk.2	-						FBXO21_uc001twj.2_Intron|FBXO21_uc009zwq.2_Intron	NM_033624	NP_296373			F-box only protein 21 isoform 1						ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			kidney(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0291)														---	---	---	---
GCN1L1	10985	broad.mit.edu	37	12	120587530	120587530	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:120587530delG	uc001txo.2	-							NM_006836	NP_006827			GCN1 general control of amino-acid synthesis						regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)																	---	---	---	---
PXN	5829	broad.mit.edu	37	12	120654813	120654813	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:120654813delG	uc001txt.2	-						PXN_uc001txu.2_5'UTR|PXN_uc001txv.2_Intron|PXN_uc001txx.2_Intron|PXN_uc001txy.2_Intron|PXN_uc001txz.2_RNA	NM_001080855	NP_001074324			paxillin isoform 1						cell junction assembly|cell-matrix adhesion|cellular response to reactive oxygen species|epidermal growth factor receptor signaling pathway|growth hormone receptor signaling pathway|muscle contraction|signal complex assembly	cytoplasm|focal adhesion|lamellipodium|microtubule associated complex	beta-catenin binding|vinculin binding|zinc ion binding			ovary(1)|breast(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)																	---	---	---	---
COQ5	84274	broad.mit.edu	37	12	120960838	120960838	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:120960838delA	uc001tyn.2	-						COQ5_uc001tyo.2_Intron|COQ5_uc010szj.1_Intron	NM_032314	NP_115690			coenzyme Q5 homolog, methyltransferase						ubiquinone biosynthetic process	mitochondrion	methyltransferase activity			ovary(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)																	---	---	---	---
RNF34	80196	broad.mit.edu	37	12	121840361	121840361	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:121840361delA	uc001ual.1	+						RNF34_uc010szw.1_Intron|RNF34_uc001uak.1_Intron|RNF34_uc001uam.1_Intron	NM_025126	NP_079402			ring finger protein 34 isoform 2						apoptosis	endomembrane system|membrane|nuclear speck	ligase activity|zinc ion binding				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000432)|Epithelial(86;0.00233)														---	---	---	---
MORN3	283385	broad.mit.edu	37	12	122091342	122091342	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:122091342delA	uc001uax.2	-						MORN3_uc001uay.2_Intron	NM_173855	NP_776254			MORN repeat containing 3												0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000409)|Epithelial(86;0.00145)														---	---	---	---
MORN3	283385	broad.mit.edu	37	12	122097296	122097296	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:122097296delG	uc001uax.2	-						MORN3_uc001uay.2_Intron	NM_173855	NP_776254			MORN repeat containing 3												0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000409)|Epithelial(86;0.00145)														---	---	---	---
KNTC1	9735	broad.mit.edu	37	12	123032139	123032139	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:123032139delT	uc001ucv.2	+						KNTC1_uc010taf.1_Intron	NM_014708	NP_055523			Rough Deal homolog, centromere/kinetochore						cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)														---	---	---	---
CCDC62	84660	broad.mit.edu	37	12	123307941	123307941	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:123307941delA	uc001udc.2	+	12	2175	c.2030delA	c.(2029-2031)CAAfs	p.Q677fs	CCDC62_uc010tah.1_Intron|CCDC62_uc001udf.2_Intron|CCDC62_uc001ude.2_Frame_Shift_Del_p.Q438fs	NM_201435	NP_958843	Q6P9F0	CCD62_HUMAN	coiled-coil domain containing 62 isoform b	677						cytoplasm|nucleus				ovary(2)|large_intestine(1)|pancreas(1)|skin(1)	5	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.51e-06)|Epithelial(86;2.65e-05)|BRCA - Breast invasive adenocarcinoma(302;0.206)														---	---	---	---
DNAH10	196385	broad.mit.edu	37	12	124293175	124293175	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:124293175delA	uc001uft.3	+						DNAH10_uc010tav.1_Intron|DNAH10_uc010taw.1_Intron	NM_207437	NP_997320			dynein, axonemal, heavy chain 10						microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)														---	---	---	---
Unknown	0	broad.mit.edu	37	12	129498825	129498825	+	IGR	DEL	T	-	-	rs112833376		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:129498825delT								GLT1D1 (29316 upstream) : TMEM132D (57446 downstream)																																			---	---	---	---
RAN	5901	broad.mit.edu	37	12	131357782	131357782	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:131357782delA	uc001uir.2	+						RAN_uc010tbk.1_Intron|RAN_uc010tbl.1_Intron|RAN_uc001uis.2_Intron	NM_006325	NP_006316			ras-related nuclear protein						androgen receptor signaling pathway|cell division|DNA metabolic process|mitosis|mitotic spindle organization|positive regulation of transcription, DNA-dependent|protein export from nucleus|RNA export from nucleus|viral genome transport in host cell|viral infectious cycle	cytosol|melanosome|nuclear pore|nucleoplasm	androgen receptor binding|chromatin binding|GTP binding|GTPase activity|transcription coactivator activity				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	Lung NSC(355;7.46e-07)|all_epithelial(31;7.36e-06)		OV - Ovarian serous cystadenocarcinoma(86;9.18e-49)|Epithelial(86;1.42e-45)|all cancers(50;6.28e-40)														---	---	---	---
LOC100101938	100101938	broad.mit.edu	37	13	19868888	19868888	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:19868888delA	uc010tck.1	-							NR_027248				Homo sapiens cDNA clone IMAGE:5265638.												0																		---	---	---	---
TPTE2	93492	broad.mit.edu	37	13	20000829	20000830	+	Intron	INS	-	TG	TG			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:20000829_20000830insTG	uc001umd.2	-						TPTE2_uc009zzk.2_Intron|TPTE2_uc009zzl.2_Intron|TPTE2_uc001ume.2_Intron|TPTE2_uc009zzm.2_Intron|TPTE2_uc010tcm.1_Intron|TPTE2_uc010tcl.1_Intron	NM_199254	NP_954863			TPTE and PTEN homologous inositol lipid							endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)														---	---	---	---
TPTE2	93492	broad.mit.edu	37	13	20041394	20041394	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:20041394delA	uc001umd.2	-	8	694	c.483delT	c.(481-483)TTTfs	p.F161fs	TPTE2_uc009zzk.2_Intron|TPTE2_uc009zzl.2_Intron|TPTE2_uc001ume.2_Intron|TPTE2_uc009zzm.2_Intron|TPTE2_uc010tcm.1_RNA	NM_199254	NP_954863	Q6XPS3	TPTE2_HUMAN	TPTE and PTEN homologous inositol lipid	161	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)														---	---	---	---
TPTE2	93492	broad.mit.edu	37	13	20137716	20137717	+	5'Flank	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:20137716_20137717insT	uc010tcm.1	-											Homo sapiens mRNA for TPIP alpha lipid phosphatase (TPIP gene).							endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)														---	---	---	---
XPO4	64328	broad.mit.edu	37	13	21381918	21381918	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:21381918delA	uc001unq.3	-							NM_022459	NP_071904			exportin 4						protein transport	cytoplasm|nucleus	protein binding			large_intestine(1)|ovary(1)|kidney(1)	3		all_cancers(29;5.05e-24)|all_epithelial(30;5.56e-20)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000521)|Epithelial(112;0.000892)|OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Lung(94;0.0189)|LUSC - Lung squamous cell carcinoma(192;0.0548)														---	---	---	---
MIPEP	4285	broad.mit.edu	37	13	24448962	24448962	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:24448962delA	uc001uox.3	-							NM_005932	NP_005923			mitochondrial intermediate peptidase precursor						protein processing involved in protein targeting to mitochondrion|proteolysis	mitochondrial matrix	metal ion binding|metalloendopeptidase activity			central_nervous_system(1)	1		all_cancers(29;1.83e-22)|all_epithelial(30;8.75e-19)|all_lung(29;9.17e-18)|Lung SC(185;0.0225)|Breast(139;0.14)		all cancers(112;0.00389)|Epithelial(112;0.0266)|OV - Ovarian serous cystadenocarcinoma(117;0.0717)|Lung(94;0.207)|GBM - Glioblastoma multiforme(144;0.232)														---	---	---	---
ATP8A2	51761	broad.mit.edu	37	13	26116337	26116338	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:26116337_26116338insA	uc001uqk.2	+						ATP8A2_uc010tdi.1_Intron|ATP8A2_uc010tdj.1_Intron|ATP8A2_uc001uql.1_Intron	NM_016529	NP_057613			ATPase, aminophospholipid transporter-like,						ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)														---	---	---	---
CDK8	1024	broad.mit.edu	37	13	26923154	26923154	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:26923154delT	uc001uqr.1	+						CDK8_uc001uqs.1_Intron|CDK8_uc001uqt.1_Intron	NM_001260	NP_001251			cyclin-dependent kinase 8						regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|large_intestine(1)|ovary(1)|skin(1)	5	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0384)|Epithelial(112;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.188)														---	---	---	---
Unknown	0	broad.mit.edu	37	13	28270838	28270838	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:28270838delT								POLR1D (29291 upstream) : GSX1 (95942 downstream)																																			---	---	---	---
ATP5EP2	432369	broad.mit.edu	37	13	28519324	28519324	+	5'Flank	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:28519324delA	uc001uru.2	+							NR_002162				Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit pseudogene 2 (ATP5EP2), transcript variant 6, non-coding RNA.											ovary(1)	1																		---	---	---	---
UBL3	5412	broad.mit.edu	37	13	30346153	30346153	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:30346153delT	uc001usp.2	-							NM_007106	NP_009037			ubiquitin-like 3 precursor							intracellular|plasma membrane					0		Lung SC(185;0.0281)		all cancers(112;0.0598)|GBM - Glioblastoma multiforme(144;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.147)														---	---	---	---
RXFP2	122042	broad.mit.edu	37	13	32313942	32313942	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:32313942delA	uc001utt.2	+						RXFP2_uc010aba.2_Intron	NM_130806	NP_570718			relaxin/insulin-like family peptide receptor 2							integral to membrane|plasma membrane					0		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)														---	---	---	---
DCLK1	9201	broad.mit.edu	37	13	36521334	36521334	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:36521334delA	uc001uvf.2	-							NM_004734	NP_004725			doublecortin-like kinase 1						cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			stomach(6)|ovary(2)|skin(1)	9		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)														---	---	---	---
C13orf23	80209	broad.mit.edu	37	13	39600600	39600600	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:39600600delA	uc001uwy.2	-						C13orf23_uc001uwz.2_Intron	NM_025138	NP_079414			hypothetical protein LOC80209 isoform 1											ovary(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)	5		Lung NSC(96;6.01e-07)|Breast(139;0.00394)|Prostate(109;0.00676)|Lung SC(185;0.0548)|Hepatocellular(188;0.114)		all cancers(112;3.7e-08)|Epithelial(112;4.28e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00114)|BRCA - Breast invasive adenocarcinoma(63;0.00366)|GBM - Glioblastoma multiforme(144;0.0146)														---	---	---	---
COG6	57511	broad.mit.edu	37	13	40256199	40256199	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:40256199delT	uc001uxh.2	+						COG6_uc001uxi.2_Intron|COG6_uc010acb.2_Intron	NM_020751	NP_065802			component of oligomeric golgi complex 6 isoform						protein transport	Golgi membrane|Golgi transport complex				kidney(1)|skin(1)	2		Lung NSC(96;0.000124)|Breast(139;0.0199)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.03e-09)|Epithelial(112;7e-07)|OV - Ovarian serous cystadenocarcinoma(117;0.00015)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.0168)														---	---	---	---
MRPS31	10240	broad.mit.edu	37	13	41323465	41323465	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:41323465delT	uc001uxm.3	-							NM_005830	NP_005821			mitochondrial ribosomal protein S31 precursor							mitochondrion|ribosome	protein domain specific binding				0		Lung NSC(96;3.55e-06)|Breast(139;0.00394)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(188;0.194)		all cancers(112;1.52e-08)|Epithelial(112;7.63e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000192)|GBM - Glioblastoma multiforme(144;0.00233)|BRCA - Breast invasive adenocarcinoma(63;0.0706)														---	---	---	---
MTRF1	9617	broad.mit.edu	37	13	41826691	41826691	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:41826691delA	uc001uxx.2	-						MTRF1_uc001uxy.2_Intron|MTRF1_uc001uxz.2_Intron|MTRF1_uc010tff.1_Intron|MTRF1_uc001uyc.1_Intron	NM_004294	NP_004285			mitochondrial translational release factor 1						regulation of translational termination	mitochondrion	translation release factor activity, codon specific				0		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)|Ovarian(182;0.125)		OV - Ovarian serous cystadenocarcinoma(117;4.24e-10)|all cancers(112;2.05e-09)|Epithelial(112;2.48e-09)|GBM - Glioblastoma multiforme(144;0.00115)|BRCA - Breast invasive adenocarcinoma(63;0.0721)|KIRC - Kidney renal clear cell carcinoma(186;0.248)														---	---	---	---
DGKH	160851	broad.mit.edu	37	13	42788583	42788583	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:42788583delA	uc001uyl.1	+						DGKH_uc010tfh.1_Intron|DGKH_uc001uym.1_Intron|DGKH_uc010tfi.1_Intron|DGKH_uc010tfj.1_Intron|DGKH_uc001uyn.1_Intron|DGKH_uc001uyo.1_Intron|DGKH_uc001uyp.2_Intron	NM_178009	NP_821077			diacylglycerol kinase, eta isoform 2						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation|protein oligomerization	endosome|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(2)	2		Lung NSC(96;1.02e-05)|Prostate(109;0.0168)|Lung SC(185;0.0262)|Breast(139;0.0709)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;5.88e-05)|GBM - Glioblastoma multiforme(144;0.000935)|BRCA - Breast invasive adenocarcinoma(63;0.109)														---	---	---	---
C13orf31	144811	broad.mit.edu	37	13	44455757	44455757	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:44455757delT	uc010acg.2	+						CCDC122_uc010acf.2_5'Flank|C13orf31_uc001uzf.3_Intron	NM_001128303	NP_001121775			hypothetical protein LOC144811												0		Lung NSC(96;0.000163)|all_hematologic(4;0.0127)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Breast(139;0.0364)|Lung SC(185;0.0367)|Acute lymphoblastic leukemia(4;0.138)		GBM - Glioblastoma multiforme(144;0.000573)|BRCA - Breast invasive adenocarcinoma(63;0.121)														---	---	---	---
TSC22D1	8848	broad.mit.edu	37	13	45090339	45090339	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:45090339delA	uc001uzn.3	-						TSC22D1_uc001uzo.1_Intron	NM_183422	NP_904358			TSC22 domain family, member 1 isoform 1						transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity				0		all_hematologic(4;8.74e-08)|Acute lymphoblastic leukemia(4;1.78e-07)|Lung NSC(96;2.21e-05)|Breast(139;0.000625)|Prostate(109;0.000947)|Hepatocellular(98;0.0202)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;0.000522)|BRCA - Breast invasive adenocarcinoma(63;0.118)														---	---	---	---
LRCH1	23143	broad.mit.edu	37	13	47269177	47269177	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:47269177delT	uc001vbj.2	+						LRCH1_uc010acp.2_Intron|LRCH1_uc001vbk.2_Intron|LRCH1_uc001vbl.3_Intron	NM_015116	NP_055931			leucine-rich repeats and calponin homology (CH)											ovary(1)|central_nervous_system(1)	2		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)														---	---	---	---
RB1	5925	broad.mit.edu	37	13	48954093	48954094	+	Intron	INS	-	A	A	rs35427721		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:48954093_48954094insA	uc001vcb.2	+							NM_000321	NP_000312			retinoblastoma 1						androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(7)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			---	---	---	---
FNDC3A	22862	broad.mit.edu	37	13	49649272	49649272	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:49649272delT	uc001vcm.2	+						FNDC3A_uc001vcl.1_Intron|FNDC3A_uc001vcn.2_Intron|FNDC3A_uc001vco.2_Intron	NM_001079673	NP_001073141			fibronectin type III domain containing 3A							Golgi membrane|integral to membrane				lung(2)	2		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)														---	---	---	---
FNDC3A	22862	broad.mit.edu	37	13	49742591	49742591	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:49742591delT	uc001vcm.2	+						FNDC3A_uc001vcn.2_Intron|FNDC3A_uc001vco.2_Intron|FNDC3A_uc001vcp.1_Intron|FNDC3A_uc001vcq.2_Intron	NM_001079673	NP_001073141			fibronectin type III domain containing 3A							Golgi membrane|integral to membrane				lung(2)	2		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)														---	---	---	---
FNDC3A	22862	broad.mit.edu	37	13	49761480	49761480	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:49761480delT	uc001vcm.2	+						FNDC3A_uc001vcn.2_Intron|FNDC3A_uc001vco.2_Intron|FNDC3A_uc001vcp.1_Intron|FNDC3A_uc001vcq.2_Intron	NM_001079673	NP_001073141			fibronectin type III domain containing 3A							Golgi membrane|integral to membrane				lung(2)	2		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)														---	---	---	---
FNDC3A	22862	broad.mit.edu	37	13	49761878	49761878	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:49761878delT	uc001vcm.2	+						FNDC3A_uc001vcn.2_Intron|FNDC3A_uc001vco.2_Intron|FNDC3A_uc001vcp.1_Intron|FNDC3A_uc001vcq.2_Intron	NM_001079673	NP_001073141			fibronectin type III domain containing 3A							Golgi membrane|integral to membrane				lung(2)	2		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)														---	---	---	---
RNASEH2B	79621	broad.mit.edu	37	13	51503561	51503562	+	Intron	DEL	TG	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:51503561_51503562delTG	uc001vfa.3	+						RNASEH2B_uc001vfb.3_Intron	NM_024570	NP_078846			ribonuclease H2, subunit B isoform 1						RNA catabolic process	nucleus|ribonuclease H2 complex					0		Acute lymphoblastic leukemia(7;1.03e-07)|Breast(56;0.00122)|Lung NSC(96;0.00143)|Prostate(109;0.0047)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;9e-08)														---	---	---	---
RNASEH2B	79621	broad.mit.edu	37	13	51527972	51527972	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:51527972delT	uc001vfa.3	+						RNASEH2B_uc001vfb.3_Intron	NM_024570	NP_078846			ribonuclease H2, subunit B isoform 1						RNA catabolic process	nucleus|ribonuclease H2 complex					0		Acute lymphoblastic leukemia(7;1.03e-07)|Breast(56;0.00122)|Lung NSC(96;0.00143)|Prostate(109;0.0047)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;9e-08)														---	---	---	---
NEK5	341676	broad.mit.edu	37	13	52661712	52661712	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:52661712delT	uc001vge.2	-							NM_199289	NP_954983			NIMA-related kinase 5								ATP binding|metal ion binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)	1		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)														---	---	---	---
SUGT1	10910	broad.mit.edu	37	13	53254127	53254129	+	In_Frame_Del	DEL	CAT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:53254127_53254129delCAT	uc001vhc.2	+	13	1058_1060	c.833_835delCAT	c.(832-837)CCATCA>CCA	p.S281del	SUGT1_uc001vha.2_RNA|SUGT1_uc001vhb.2_In_Frame_Del_p.S249del|SUGT1_uc010thb.1_In_Frame_Del_p.S193del|SUGT1_uc001vhd.2_In_Frame_Del_p.S138del	NM_001130912	NP_001124384	Q9Y2Z0	SUGT1_HUMAN	suppressor of G2 allele of SKP1 isoform a	281	SGS.				mitosis	kinetochore|ubiquitin ligase complex	binding				0		Lung NSC(96;0.00212)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.25e-08)														---	---	---	---
DIAPH3	81624	broad.mit.edu	37	13	60240695	60240695	+	3'UTR	DEL	T	-	-	rs111915155	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:60240695delT	uc001vht.2	-	28					DIAPH3_uc001vhs.2_RNA	NM_001042517	NP_001035982			diaphanous homolog 3 isoform a						actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)														---	---	---	---
TDRD3	81550	broad.mit.edu	37	13	61057789	61057789	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:61057789delT	uc001via.2	+						TDRD3_uc010aef.2_Intron|TDRD3_uc001vhz.3_Intron|TDRD3_uc010aeg.2_Intron|TDRD3_uc001vib.3_Intron	NM_030794	NP_110421			tudor domain containing 3 isoform 2						chromatin modification	cytoplasm|nucleus	chromatin binding|methylated histone residue binding|nucleic acid binding|transcription coactivator activity			upper_aerodigestive_tract(1)|skin(1)	2		Prostate(109;0.173)|Breast(118;0.174)		GBM - Glioblastoma multiforme(99;0.000291)														---	---	---	---
Unknown	0	broad.mit.edu	37	13	77562830	77562830	+	IGR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:77562830delA								BTF3L1 (59607 upstream) : CLN5 (3229 downstream)																																			---	---	---	---
MYCBP2	23077	broad.mit.edu	37	13	77644557	77644557	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:77644557delT	uc001vkf.2	-						MYCBP2_uc010aev.2_Intron|MYCBP2_uc001vke.2_Intron	NM_015057	NP_055872			MYC binding protein 2						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)														---	---	---	---
MYCBP2	23077	broad.mit.edu	37	13	77725048	77725048	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:77725048delT	uc001vkf.2	-	48	6929	c.6838delA	c.(6838-6840)ATGfs	p.M2280fs	MYCBP2_uc010aev.2_Frame_Shift_Del_p.M1684fs	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	2280					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)														---	---	---	---
MYCBP2	23077	broad.mit.edu	37	13	77780725	77780725	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:77780725delA	uc001vkf.2	-						MYCBP2_uc010aev.2_Intron	NM_015057	NP_055872			MYC binding protein 2						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)														---	---	---	---
SLAIN1	122060	broad.mit.edu	37	13	78320722	78320722	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:78320722delA	uc010thy.1	+	4	541	c.498delA	c.(496-498)GGAfs	p.G166fs	SLAIN1_uc001vkk.1_Frame_Shift_Del_p.G89fs|SLAIN1_uc001vkl.1_Frame_Shift_Del_p.G45fs|SLAIN1_uc010thz.1_Frame_Shift_Del_p.G44fs|SLAIN1_uc010aex.1_Intron|SLAIN1_uc010aey.1_Intron|SLAIN1_uc001vkm.2_Frame_Shift_Del_p.G45fs	NM_144595	NP_653196	Q8ND83	SLAI1_HUMAN	SLAIN motif family, member 1 B	308										ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0853)														---	---	---	---
RBM26	64062	broad.mit.edu	37	13	79919065	79919067	+	Intron	DEL	ATA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:79919065_79919067delATA	uc001vkz.2	-						RBM26_uc001vky.2_Intron|RBM26_uc001vla.2_Intron|RBM26_uc010tia.1_Intron|RBM26_uc001vkx.2_Intron	NM_022118	NP_071401			RNA binding motif protein 26						mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)														---	---	---	---
GPR180	160897	broad.mit.edu	37	13	95279495	95279495	+	3'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:95279495delT	uc001vly.2	+	9					GPR180_uc001vlz.2_3'UTR|GPR180_uc010afi.2_3'UTR	NM_180989	NP_851320			G protein-coupled receptor 180 precursor							integral to membrane				breast(1)	1	all_neural(89;0.0684)|Medulloblastoma(90;0.163)																	---	---	---	---
DOCK9	23348	broad.mit.edu	37	13	99540398	99540398	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:99540398delA	uc001vnt.2	-						DOCK9_uc001vnw.2_Intron|DOCK9_uc001vnv.1_Intron|DOCK9_uc010tir.1_Intron|DOCK9_uc010tis.1_Intron|DOCK9_uc010tit.1_Intron|DOCK9_uc010afu.1_Intron	NM_015296	NP_056111			dedicator of cytokinesis 9 isoform a						blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)																	---	---	---	---
CLYBL	171425	broad.mit.edu	37	13	100543841	100543841	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:100543841delA	uc001vok.2	+							NM_206808	NP_996531			citrate lyase beta like precursor						cellular aromatic compound metabolic process	citrate lyase complex|mitochondrion	citrate (pro-3S)-lyase activity|metal ion binding				0	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)																	---	---	---	---
TPP2	7174	broad.mit.edu	37	13	103303828	103303828	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:103303828delT	uc001vpi.3	+							NM_003291	NP_003282			tripeptidyl peptidase II						proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)																	---	---	---	---
TNFSF13B	10673	broad.mit.edu	37	13	108955486	108955486	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:108955486delT	uc001vqr.2	+						TNFSF13B_uc010agj.2_Intron|TNFSF13B_uc001vqs.1_Intron	NM_006573	NP_006564			tumor necrosis factor superfamily, member 13b						cell proliferation|immune response|signal transduction	extracellular space|integral to membrane|plasma membrane|soluble fraction	cytokine activity|tumor necrosis factor receptor binding				0	all_lung(23;0.000396)|all_neural(89;0.00256)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00902)|Lung SC(71;0.104)		all cancers(43;0.184)|BRCA - Breast invasive adenocarcinoma(86;0.19)															---	---	---	---
ANKRD10	55608	broad.mit.edu	37	13	111532562	111532562	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:111532562delT	uc001vrn.2	-						ANKRD10_uc001vrm.2_Intron|ANKRD10_uc001vrl.2_RNA	NM_017664	NP_060134			ankyrin repeat domain 10											central_nervous_system(1)	1	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		all cancers(43;0.0882)|BRCA - Breast invasive adenocarcinoma(86;0.188)|Lung(89;0.208)															---	---	---	---
TFDP1	7027	broad.mit.edu	37	13	114288674	114288674	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:114288674delA	uc001vtw.2	+						TFDP1_uc010tkd.1_Intron|TFDP1_uc010tke.1_Intron|TFDP1_uc001vty.3_Intron|TFDP1_uc001vtx.2_Intron	NM_007111	NP_009042			transcription factor Dp-1						cell proliferation|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|regulation of transcription from RNA polymerase II promoter	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			lung(4)|ovary(2)|skin(1)	7	Lung NSC(43;0.0113)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.132)|all_epithelial(44;0.0731)|all_lung(25;0.149)|Breast(118;0.153)	all cancers(43;0.0576)												TSP Lung(29;0.18)			---	---	---	---
PARP2	10038	broad.mit.edu	37	14	20822890	20822890	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:20822890delT	uc001vxc.2	+						PARP2_uc001vxd.2_Intron|PARP2_uc001vxb.1_Intron|PARP2_uc010tle.1_Intron	NM_005484	NP_005475			poly (ADP-ribose) polymerase family, member 2						protein ADP-ribosylation	nucleolus|nucleoplasm	DNA binding|NAD+ ADP-ribosyltransferase activity			ovary(1)|pancreas(1)	2	all_cancers(95;0.00092)	all_lung(585;0.235)	Epithelial(56;5.34e-07)|all cancers(55;3.7e-06)	GBM - Glioblastoma multiforme(265;0.00888)|READ - Rectum adenocarcinoma(17;0.0649)									Direct_reversal_of_damage|PARP_enzymes_that_bind_to_DNA					---	---	---	---
PARP2	10038	broad.mit.edu	37	14	20824816	20824817	+	Frame_Shift_Ins	INS	-	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:20824816_20824817insC	uc001vxc.2	+	13	1364_1365	c.1336_1337insC	c.(1336-1338)GCCfs	p.A446fs	PARP2_uc001vxd.2_Frame_Shift_Ins_p.A433fs|PARP2_uc001vxb.1_Frame_Shift_Ins_p.A446fs|PARP2_uc010tle.1_Frame_Shift_Ins_p.A196fs	NM_005484	NP_005475	Q9UGN5	PARP2_HUMAN	poly (ADP-ribose) polymerase family, member 2	446	PARP catalytic.				protein ADP-ribosylation	nucleolus|nucleoplasm	DNA binding|NAD+ ADP-ribosyltransferase activity			ovary(1)|pancreas(1)	2	all_cancers(95;0.00092)	all_lung(585;0.235)	Epithelial(56;5.34e-07)|all cancers(55;3.7e-06)	GBM - Glioblastoma multiforme(265;0.00888)|READ - Rectum adenocarcinoma(17;0.0649)									Direct_reversal_of_damage|PARP_enzymes_that_bind_to_DNA					---	---	---	---
METT11D1	64745	broad.mit.edu	37	14	21460882	21460882	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:21460882delT	uc001vyn.2	+						METT11D1_uc010tlk.1_3'UTR|METT11D1_uc001vym.2_Intron|METT11D1_uc001vyo.2_Intron|METT11D1_uc001vyp.2_Intron|METT11D1_uc001vyq.2_Intron	NM_022734	NP_073571			methyltransferase 11 domain containing 1 isoform						translation	mitochondrion|ribosome	copper ion binding|methyltransferase activity				0	all_cancers(95;0.00267)		OV - Ovarian serous cystadenocarcinoma(11;1.34e-10)|Epithelial(56;1.57e-08)|all cancers(55;7.45e-08)	GBM - Glioblastoma multiforme(265;0.0191)														---	---	---	---
RPGRIP1	57096	broad.mit.edu	37	14	21788458	21788458	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:21788458delT	uc001wag.2	+						RPGRIP1_uc001wah.2_Intron|RPGRIP1_uc001wai.2_Intron|RPGRIP1_uc001waj.1_5'Flank|RPGRIP1_uc001wak.2_5'Flank|RPGRIP1_uc010aim.2_5'Flank|RPGRIP1_uc001wal.2_5'Flank	NM_020366	NP_065099			retinitis pigmentosa GTPase regulator						response to stimulus|visual perception	cilium				ovary(4)|breast(2)|pancreas(1)	7	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)														---	---	---	---
SUPT16H	11198	broad.mit.edu	37	14	21825642	21825642	+	Intron	DEL	T	-	-	rs77960204	byFrequency;by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:21825642delT	uc001wao.2	-						SUPT16H_uc001wan.2_Intron	NM_007192	NP_009123			chromatin-specific transcription elongation						DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding				0	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)														---	---	---	---
SUPT16H	11198	broad.mit.edu	37	14	21838337	21838337	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:21838337delA	uc001wao.2	-							NM_007192	NP_009123			chromatin-specific transcription elongation						DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding				0	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)														---	---	---	---
TOX4	9878	broad.mit.edu	37	14	21967125	21967127	+	3'UTR	DEL	AAT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:21967125_21967127delAAT	uc001waz.2	+	9					TOX4_uc001wba.2_RNA|TOX4_uc010tlu.1_3'UTR|TOX4_uc010tlv.1_3'UTR|METTL3_uc001wbb.2_Intron|METTL3_uc001wbc.2_Intron	NM_014828	NP_055643			epidermal Langerhans cell protein LCP1							chromatin|nucleus|PTW/PP1 phosphatase complex	DNA binding|protein binding			ovary(1)	1	all_cancers(95;0.000465)		Epithelial(56;6.61e-06)|all cancers(55;5.15e-05)	GBM - Glioblastoma multiforme(265;0.0149)														---	---	---	---
HOMEZ	57594	broad.mit.edu	37	14	23764328	23764329	+	Intron	DEL	AC	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:23764328_23764329delAC	uc001wjb.2	-							NM_020834	NP_065885			homeodomain leucine zipper protein							nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(95;5.54e-06)			GBM - Glioblastoma multiforme(265;0.00643)														---	---	---	---
HOMEZ	57594	broad.mit.edu	37	14	23764733	23764733	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:23764733delA	uc001wjb.2	-							NM_020834	NP_065885			homeodomain leucine zipper protein							nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(95;5.54e-06)			GBM - Glioblastoma multiforme(265;0.00643)														---	---	---	---
AP1G2	8906	broad.mit.edu	37	14	24031937	24031937	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:24031937delC	uc001wkl.2	-						AP1G2_uc001wkj.2_Intron|AP1G2_uc001wkk.3_Intron|AP1G2_uc001wkn.2_Intron|uc001wko.1_Intron|AP1G2_uc001wkp.1_RNA	NM_003917	NP_003908			adaptor-related protein complex 1, gamma 2						interspecies interaction between organisms|intracellular protein transport|vesicle-mediated transport	AP-1 adaptor complex|endosome membrane	protein binding|protein transporter activity			ovary(1)	1	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00672)												OREG0022605	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
LRRC16B	90668	broad.mit.edu	37	14	24535368	24535368	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:24535368delT	uc001wlj.2	+						LRRC16B_uc001wlk.2_Intron	NM_138360	NP_612369			leucine rich repeat containing 16B											ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(265;0.019)														---	---	---	---
CBLN3	643866	broad.mit.edu	37	14	24898055	24898055	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:24898055delG	uc001wpg.3	-	1	677	c.206delC	c.(205-207)CCTfs	p.P69fs	KHNYN_uc010tpc.1_5'Flank|KHNYN_uc001wph.3_5'Flank|KHNYN_uc010alw.2_5'Flank	NM_001039771	NP_001034860	Q6UW01	CBLN3_HUMAN	cerebellin 3 precursor	69	C1q.					cell junction|extracellular region|synapse				central_nervous_system(1)	1				GBM - Glioblastoma multiforme(265;0.00159)														---	---	---	---
G2E3	55632	broad.mit.edu	37	14	31066424	31066424	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:31066424delT	uc001wqk.2	+						G2E3_uc010tpe.1_Intron|G2E3_uc010tpf.1_Intron	NM_017769	NP_060239			G2/M-phase specific E3 ubiquitin ligase						apoptosis|multicellular organismal development|protein modification process	Golgi apparatus|nucleolus	acid-amino acid ligase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3																		---	---	---	---
SCFD1	23256	broad.mit.edu	37	14	31177400	31177400	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:31177400delT	uc001wqm.1	+						SCFD1_uc001wqn.1_Intron|SCFD1_uc010tpg.1_Intron|SCFD1_uc010tph.1_Intron|SCFD1_uc010amf.1_Intron|SCFD1_uc010tpi.1_Intron|SCFD1_uc010amd.1_Intron|SCFD1_uc010ame.1_Intron	NM_016106	NP_057190			vesicle transport-related protein isoform a						post-Golgi vesicle-mediated transport|protein transport|regulation of ER to Golgi vesicle-mediated transport|response to toxin|retrograde vesicle-mediated transport, Golgi to ER|vesicle docking involved in exocytosis	cis-Golgi network|endoplasmic reticulum membrane|Golgi cisterna membrane|Golgi-associated vesicle|plasma membrane	syntaxin-5 binding				0	Hepatocellular(127;0.0877)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)	GBM - Glioblastoma multiforme(265;0.0181)														---	---	---	---
SNX6	58533	broad.mit.edu	37	14	35078687	35078697	+	Intron	DEL	AAAAAAAAAAA	-	-	rs72407029		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:35078687_35078697delAAAAAAAAAAA	uc001wsf.1	-						SNX6_uc001wse.1_Intron|SNX6_uc010tpm.1_Intron|SNX6_uc010amm.1_Intron	NM_152233	NP_689419			sorting nexin 6 isoform b						cell communication|intracellular protein transport|negative regulation of epidermal growth factor receptor activity|negative regulation of transcription, DNA-dependent|negative regulation of transforming growth factor beta receptor signaling pathway|retrograde transport, endosome to Golgi	cytoplasmic vesicle membrane|early endosome membrane|nucleus	phosphatidylinositol binding|protein homodimerization activity				0	Breast(36;0.0473)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00199)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.0245)														---	---	---	---
RALGAPA1	253959	broad.mit.edu	37	14	36039810	36039810	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:36039810delA	uc001wti.2	-						RALGAPA1_uc010amp.2_Intron|RALGAPA1_uc001wtj.2_Intron|RALGAPA1_uc010tpv.1_Intron|RALGAPA1_uc010tpw.1_Intron	NM_014990	NP_055805			Ral GTPase activating protein, alpha subunit 1						activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4																		---	---	---	---
NKX2-1	7080	broad.mit.edu	37	14	36988636	36988636	+	5'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:36988636delT	uc001wtt.2	-	1					SFTA3_uc001wts.2_Intron|NKX2-1_uc001wtu.2_Intron|NKX2-1_uc001wtv.2_Intron|uc001wtw.1_RNA	NM_003317	NP_003308			thyroid transcription factor 1 isoform 2						epithelial tube branching involved in lung morphogenesis|globus pallidus development|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|thyroid gland development		protein binding|transcription regulatory region DNA binding			skin(1)	1	all_cancers(3;4.47e-51)|Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)|Breast(36;0.165)		Lung(8;1.8e-08)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.014)|all cancers(34;0.0366)|LUSC - Lung squamous cell carcinoma(13;0.132)	GBM - Glioblastoma multiforme(112;0.0171)				A		NSCLC								---	---	---	---
MIPOL1	145282	broad.mit.edu	37	14	38016070	38016070	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:38016070delT	uc001wuc.2	+						MIPOL1_uc001wud.2_Intron|MIPOL1_uc010ams.2_Intron|MIPOL1_uc001wue.2_Intron|MIPOL1_uc010amt.2_Intron	NM_138731	NP_620059			mirror-image polydactyly 1											ovary(1)|central_nervous_system(1)	2	Breast(36;0.119)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;6.03e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.047)|all cancers(34;0.0953)|LUSC - Lung squamous cell carcinoma(13;0.0975)|BRCA - Breast invasive adenocarcinoma(188;0.196)	GBM - Glioblastoma multiforme(112;0.0358)														---	---	---	---
Unknown	0	broad.mit.edu	37	14	38311298	38311298	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:38311298delA	uc001wug.2	+						uc001wuh.2_Intron|uc001wui.2_Intron|uc001wuj.2_Intron					Homo sapiens chromosome 14 open reading frame 25, mRNA (cDNA clone IMAGE:5268731), partial cds.																														---	---	---	---
LRFN5	145581	broad.mit.edu	37	14	42373608	42373608	+	3'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:42373608delT	uc001wvm.2	+	6					LRFN5_uc010ana.2_3'UTR	NM_152447	NP_689660			leucine rich repeat and fibronectin type III							integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)											HNSCC(30;0.082)			---	---	---	---
C14orf106	55320	broad.mit.edu	37	14	45686483	45686484	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:45686483_45686484insA	uc001wwf.2	-							NM_018353	NP_060823			chromosome 14 open reading frame 106						cell division|CenH3-containing nucleosome assembly at centromere|mitosis	chromosome, centromeric region|nucleoplasm	DNA binding				0																		---	---	---	---
C14orf138	79609	broad.mit.edu	37	14	50576439	50576439	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:50576439delA	uc001wxo.1	-						C14orf138_uc001wxn.1_Intron|C14orf138_uc001wxp.1_Intron|C14orf138_uc001wxq.1_Intron	NM_024558	NP_078834			hypothetical protein LOC79609 isoform a								methyltransferase activity				0	all_epithelial(31;0.000822)|Breast(41;0.0065)																	---	---	---	---
CDKL1	8814	broad.mit.edu	37	14	50802640	50802640	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:50802640delA	uc001wxz.2	-							NM_004196	NP_004187			cyclin-dependent kinase-like 1							cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			ovary(1)|stomach(1)	2	all_epithelial(31;0.000746)|Breast(41;0.0102)																	---	---	---	---
ATL1	51062	broad.mit.edu	37	14	51088550	51088550	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:51088550delT	uc001wyf.3	+						ATL1_uc001wyd.3_Intron|ATL1_uc001wye.3_Intron	NM_015915	NP_056999			atlastin GTPase 1 isoform a						axonogenesis|cell death|endoplasmic reticulum organization|protein homooligomerization	axon|endoplasmic reticulum membrane|Golgi cis cisterna|Golgi membrane|integral to membrane|microsome	GTP binding|GTPase activity|identical protein binding			skin(3)|central_nervous_system(1)	4																		---	---	---	---
ERO1L	30001	broad.mit.edu	37	14	53119713	53119713	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:53119713delA	uc001wzv.2	-						ERO1L_uc001wzw.2_Intron|ERO1L_uc010aof.2_Intron	NM_014584	NP_055399			ERO1-like precursor						chaperone mediated protein folding requiring cofactor|electron transport chain|protein thiol-disulfide exchange|response to temperature stimulus|transport	endoplasmic reticulum lumen|endoplasmic reticulum membrane|microsome	disulfide oxidoreductase activity|flavin adenine dinucleotide binding|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor				0	Breast(41;0.226)																	---	---	---	---
DDHD1	80821	broad.mit.edu	37	14	53513330	53513330	+	3'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:53513330delT	uc001xai.2	-	13					DDHD1_uc001xaj.2_3'UTR|DDHD1_uc001xah.2_3'UTR|DDHD1_uc001xag.2_3'UTR	NM_001160148	NP_001153620			DDHD domain containing 1 isoform c						lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			ovary(2)	2	Breast(41;0.037)																	---	---	---	---
DDHD1	80821	broad.mit.edu	37	14	53558734	53558734	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:53558734delA	uc001xai.2	-						DDHD1_uc001xaj.2_Intron|DDHD1_uc001xah.2_Intron|DDHD1_uc001xag.2_5'UTR	NM_001160148	NP_001153620			DDHD domain containing 1 isoform c						lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			ovary(2)	2	Breast(41;0.037)																	---	---	---	---
CDKN3	1033	broad.mit.edu	37	14	54868069	54868069	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:54868069delT	uc001xap.2	+						CDKN3_uc001xar.2_Intron|CDKN3_uc001xaq.2_Intron|CDKN3_uc010aoi.1_Intron|CDKN3_uc001xas.1_Intron|CDKN3_uc010aoj.1_Intron	NM_005192	NP_005183			cyclin-dependent kinase inhibitor 3 isoform 1						cell cycle arrest|G1/S transition of mitotic cell cycle|negative regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity	perinuclear region of cytoplasm	protein binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	14	55404820	55404820	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:55404820delT								GCH1 (35278 upstream) : WDHD1 (2122 downstream)																																			---	---	---	---
PSMA3	5684	broad.mit.edu	37	14	58718839	58718839	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:58718839delC	uc001xdj.1	+	3	153	c.107delC	c.(106-108)ACAfs	p.T36fs	C14orf37_uc010tro.1_Intron|PSMA3_uc001xdk.1_Frame_Shift_Del_p.T36fs	NM_002788	NP_002779	P25788	PSA3_HUMAN	proteasome alpha 3 subunit isoform 1	36					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	protein binding|threonine-type endopeptidase activity				0																		---	---	---	---
C14orf37	145407	broad.mit.edu	37	14	58727860	58727861	+	Intron	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:58727860_58727861delTT	uc010tro.1	-						PSMA3_uc001xdj.1_Intron|PSMA3_uc001xdk.1_Intron	NM_001001872	NP_001001872			hypothetical protein LOC145407 precursor							integral to membrane	binding				0																		---	---	---	---
RTN1	6252	broad.mit.edu	37	14	60072086	60072086	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:60072086delT	uc001xen.1	-	5	2321	c.2112delA	c.(2110-2112)AAAfs	p.K704fs	RTN1_uc001xem.1_Frame_Shift_Del_p.K284fs|RTN1_uc001xek.1_Frame_Shift_Del_p.K136fs|RTN1_uc001xel.1_RNA|RTN1_uc010apl.1_Frame_Shift_Del_p.K121fs	NM_021136	NP_066959	Q16799	RTN1_HUMAN	reticulon 1 isoform A	704	Reticulon.				neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0968)														---	---	---	---
MTHFD1	4522	broad.mit.edu	37	14	64867679	64867679	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:64867679delT	uc001xhb.2	+						MTHFD1_uc010aqe.2_Intron|MTHFD1_uc010aqf.2_Intron	NM_005956	NP_005947			methylenetetrahydrofolate dehydrogenase 1						folic acid metabolic process|folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process	cytosol|mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|methylenetetrahydrofolate dehydrogenase|protein binding			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(108;8.7e-12)|all cancers(60;3.29e-11)|BRCA - Breast invasive adenocarcinoma(234;0.0488)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)													---	---	---	---
C14orf50	145376	broad.mit.edu	37	14	65055769	65055770	+	Intron	INS	-	AC	AC			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:65055769_65055770insAC	uc001xhl.1	+						C14orf50_uc001xhm.1_Intron	NM_172365	NP_758953			hypothetical protein LOC145376											skin(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.00382)|all cancers(60;0.00427)|BRCA - Breast invasive adenocarcinoma(234;0.0488)														---	---	---	---
MAX	4149	broad.mit.edu	37	14	65551115	65551116	+	Intron	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:65551115_65551116delAA	uc001xif.1	-						MAX_uc001xic.1_Intron|MAX_uc001xie.1_Intron|MAX_uc010aql.1_Intron|MAX_uc001xig.1_Intron|MAX_uc001xih.1_Intron|MAX_uc001xii.1_Intron|MAX_uc001xij.1_Intron|MAX_uc001xik.2_Intron	NM_002382	NP_002373			MAX protein isoform a						transcription from RNA polymerase II promoter	cytoplasm|MLL1 complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			lung(1)	1				all cancers(60;0.000776)|OV - Ovarian serous cystadenocarcinoma(108;0.00359)|BRCA - Breast invasive adenocarcinoma(234;0.00999)														---	---	---	---
FUT8	2530	broad.mit.edu	37	14	66096358	66096358	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:66096358delA	uc001xin.2	+						FUT8_uc001xio.2_Intron|FUT8_uc010tsp.1_Intron|FUT8_uc001xir.3_Intron|FUT8_uc001xip.2_Intron|FUT8_uc001xiq.2_Intron	NM_178155	NP_835368			fucosyltransferase 8 isoform a						in utero embryonic development|L-fucose catabolic process|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in Golgi|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	glycoprotein 6-alpha-L-fucosyltransferase activity|SH3 domain binding			ovary(1)	1				all cancers(60;0.00109)|OV - Ovarian serous cystadenocarcinoma(108;0.00242)|BRCA - Breast invasive adenocarcinoma(234;0.0114)														---	---	---	---
ZFYVE26	23503	broad.mit.edu	37	14	68222413	68222413	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:68222413delT	uc001xka.2	-						ZFYVE26_uc010tsz.1_Intron|ZFYVE26_uc001xkb.2_Intron	NM_015346	NP_056161			zinc finger, FYVE domain containing 26						cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)														---	---	---	---
SLC39A9	55334	broad.mit.edu	37	14	69890833	69890833	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:69890833delT	uc001xle.2	+	2	799	c.119delT	c.(118-120)GTTfs	p.V40fs	SLC39A9_uc001xld.3_RNA|SLC39A9_uc010aqx.2_Frame_Shift_Del_p.V40fs|SLC39A9_uc001xlf.3_Frame_Shift_Del_p.V40fs|SLC39A9_uc001xlg.3_RNA	NM_018375	NP_060845	Q9NUM3	S39A9_HUMAN	solute carrier family 39 (zinc transporter),	40	Helical; (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity				0				all cancers(60;0.00299)|BRCA - Breast invasive adenocarcinoma(234;0.0145)|OV - Ovarian serous cystadenocarcinoma(108;0.0373)														---	---	---	---
PCNX	22990	broad.mit.edu	37	14	71502647	71502647	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:71502647delT	uc001xmo.2	+						PCNX_uc010are.1_Intron|PCNX_uc010arf.1_Intron	NM_014982	NP_055797			pecanex-like 1							integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)														---	---	---	---
NUMB	8650	broad.mit.edu	37	14	73789849	73789849	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:73789849delT	uc001xny.1	-	5	510	c.190delA	c.(190-192)AGAfs	p.R64fs	NUMB_uc010aro.1_Frame_Shift_Del_p.R64fs|NUMB_uc010arp.1_Frame_Shift_Del_p.R64fs|NUMB_uc010arq.1_Frame_Shift_Del_p.R64fs|NUMB_uc010arr.1_Frame_Shift_Del_p.R64fs|NUMB_uc001xoa.1_Frame_Shift_Del_p.R64fs|NUMB_uc001xnz.1_Frame_Shift_Del_p.R64fs|NUMB_uc001xob.1_Frame_Shift_Del_p.R64fs|NUMB_uc001xod.1_Frame_Shift_Del_p.R64fs|NUMB_uc001xoc.1_Frame_Shift_Del_p.R64fs|NUMB_uc010ars.1_Frame_Shift_Del_p.R64fs|NUMB_uc001xof.1_Intron|NUMB_uc001xog.2_Frame_Shift_Del_p.R64fs|NUMB_uc001xoh.1_Frame_Shift_Del_p.R64fs	NM_001005743	NP_001005743	P49757	NUMB_HUMAN	numb homolog isoform 1	64	PID.				axon guidance|lateral ventricle development|neuroblast division in subventricular zone|positive regulation of neurogenesis	integral to plasma membrane				ovary(2)|central_nervous_system(1)|skin(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00471)|OV - Ovarian serous cystadenocarcinoma(108;0.161)														---	---	---	---
ACOT4	122970	broad.mit.edu	37	14	74060211	74060211	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:74060211delA	uc001xoo.2	+							NM_152331	NP_689544			acyl-CoA thioesterase 4						acyl-CoA metabolic process|dicarboxylic acid metabolic process|long-chain fatty acid metabolic process|saturated monocarboxylic acid metabolic process|short-chain fatty acid metabolic process|succinyl-CoA metabolic process|unsaturated monocarboxylic acid metabolic process|very long-chain fatty acid metabolic process	peroxisome	carboxylesterase activity|palmitoyl-CoA hydrolase activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00331)														---	---	---	---
ACOT6	641372	broad.mit.edu	37	14	74085840	74085841	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:74085840_74085841insA	uc001xop.2	+							NM_001037162	NP_001032239			acyl-CoA thioesterase 6							cytosol	carboxylesterase activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00331)														---	---	---	---
KIAA0317	9870	broad.mit.edu	37	14	75131486	75131486	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:75131486delT	uc001xqb.2	-						KIAA0317_uc010tut.1_Intron	NM_001039479	NP_001034568			hypothetical protein LOC9870						protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane|intracellular	ubiquitin-protein ligase activity			ovary(2)|kidney(1)|central_nervous_system(1)|pancreas(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00404)														---	---	---	---
PROX2	283571	broad.mit.edu	37	14	75323918	75323918	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:75323918delT	uc001xqr.1	-						PROX2_uc001xqq.1_Intron	NM_001080408	NP_001073877			prospero homeobox 2						multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00652)														---	---	---	---
NEK9	91754	broad.mit.edu	37	14	75581161	75581161	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:75581161delA	uc001xrl.2	-						NEK9_uc001xrk.2_Intron	NM_033116	NP_149107			NIMA-related kinase 9						cell division|mitosis	mitochondrion|nucleus	ATP binding|metal ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(2)|stomach(2)|ovary(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00718)														---	---	---	---
NEK9	91754	broad.mit.edu	37	14	75585642	75585642	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:75585642delA	uc001xrl.2	-						NEK9_uc001xrk.2_5'Flank	NM_033116	NP_149107			NIMA-related kinase 9						cell division|mitosis	mitochondrion|nucleus	ATP binding|metal ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(2)|stomach(2)|ovary(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00718)														---	---	---	---
TTLL5	23093	broad.mit.edu	37	14	76224332	76224332	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:76224332delA	uc001xrx.2	+						TTLL5_uc010ask.1_Intron|TTLL5_uc001xrz.2_Intron|TTLL5_uc001xry.1_Intron	NM_015072	NP_055887			tubulin tyrosine ligase-like family, member 5						protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.029)														---	---	---	---
TMEM63C	57156	broad.mit.edu	37	14	77709477	77709477	+	Intron	DEL	A	-	-	rs409306	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:77709477delA	uc001xtf.2	+						TMEM63C_uc010asq.1_Intron	NM_020431	NP_065164			transmembrane protein 63C							integral to membrane					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0342)														---	---	---	---
SEL1L	6400	broad.mit.edu	37	14	81951796	81951797	+	Intron	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:81951796_81951797delTT	uc010tvv.1	-							NM_005065	NP_005056			sel-1 suppressor of lin-12-like precursor						Notch signaling pathway	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0299)														---	---	---	---
GALC	2581	broad.mit.edu	37	14	88434638	88434638	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:88434638delT	uc001xvt.2	-						GALC_uc010tvw.1_Intron|GALC_uc010tvx.1_Intron|GALC_uc010tvy.1_Intron|GALC_uc010tvz.1_Intron|GALC_uc001xvu.1_Intron	NM_000153	NP_000144			galactosylceramidase isoform a precursor						carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity				0																		---	---	---	---
PTPN21	11099	broad.mit.edu	37	14	88971527	88971527	+	Intron	DEL	T	-	-	rs80302635		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:88971527delT	uc001xwv.3	-						PTPN21_uc010twc.1_Intron|PTPN21_uc010atf.1_Intron	NM_007039	NP_008970			protein tyrosine phosphatase, non-receptor type							cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4																		---	---	---	---
PTPN21	11099	broad.mit.edu	37	14	88983754	88983754	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:88983754delA	uc001xwv.3	-						PTPN21_uc010twc.1_Intron|PTPN21_uc010atf.1_Intron	NM_007039	NP_008970			protein tyrosine phosphatase, non-receptor type							cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4																		---	---	---	---
FOXN3	1112	broad.mit.edu	37	14	89656891	89656891	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:89656891delA	uc001xxo.3	-						FOXN3_uc001xxn.3_Intron|FOXN3_uc010atk.2_Intron	NM_001085471	NP_001078940			checkpoint suppressor 1 isoform 1						DNA damage checkpoint|embryo development|G2 phase of mitotic cell cycle|negative regulation of transcription, DNA-dependent|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein C-terminus binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(2)|ovary(1)	3																		---	---	---	---
CPSF2	53981	broad.mit.edu	37	14	92623949	92623949	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:92623949delT	uc001yah.1	+							NM_017437	NP_059133			cleavage and polyadenylation specific factor 2						histone mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	hydrolase activity|protein binding|RNA binding			ovary(2)	2		all_cancers(154;0.0766)		COAD - Colon adenocarcinoma(157;0.222)														---	---	---	---
BTBD7	55727	broad.mit.edu	37	14	93760502	93760502	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:93760502delA	uc001ybo.2	-	3	1190	c.864delT	c.(862-864)TTTfs	p.F288fs	BTBD7_uc010aur.2_5'UTR|BTBD7_uc010two.1_Frame_Shift_Del_p.F203fs|BTBD7_uc001ybp.2_Intron|BTBD7_uc001ybq.3_Frame_Shift_Del_p.F203fs|BTBD7_uc001ybr.2_Frame_Shift_Del_p.F288fs	NM_001002860	NP_001002860	Q9P203	BTBD7_HUMAN	BTB (POZ) domain containing 7 isoform 1	288	BTB 2.									pancreas(1)	1		all_cancers(154;0.08)		Epithelial(152;0.196)|COAD - Colon adenocarcinoma(157;0.212)|all cancers(159;0.223)														---	---	---	---
KIAA1409	57578	broad.mit.edu	37	14	94087521	94087522	+	Intron	DEL	TA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:94087521_94087522delTA	uc001ybv.1	+						KIAA1409_uc001ybs.1_Intron	NM_020818	NP_065869			hypothetical protein LOC57578							integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)														---	---	---	---
CLMN	79789	broad.mit.edu	37	14	95670828	95670829	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:95670828_95670829insA	uc001yef.2	-							NM_024734	NP_079010			calmin							integral to membrane	actin binding				0				Epithelial(152;0.193)														---	---	---	---
CLMN	79789	broad.mit.edu	37	14	95676982	95676983	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:95676982_95676983insA	uc001yef.2	-							NM_024734	NP_079010			calmin							integral to membrane	actin binding				0				Epithelial(152;0.193)														---	---	---	---
ATG2B	55102	broad.mit.edu	37	14	96784253	96784253	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:96784253delA	uc001yfi.2	-							NM_018036	NP_060506			ATG2 autophagy related 2 homolog B											ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)														---	---	---	---
AK7	122481	broad.mit.edu	37	14	96953557	96953559	+	Intron	DEL	AAA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:96953557_96953559delAAA	uc001yfn.2	+							NM_152327	NP_689540			adenylate kinase 7						cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			ovary(1)	1		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)														---	---	---	---
PAPOLA	10914	broad.mit.edu	37	14	96998599	96998599	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:96998599delT	uc001yfq.2	+						PAPOLA_uc001yfp.2_Intron|PAPOLA_uc001yfr.2_Intron|PAPOLA_uc010twv.1_Intron|PAPOLA_uc010avp.2_Intron	NM_032632	NP_116021			poly(A) polymerase alpha						mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|RNA binding				0		all_cancers(154;0.0555)|all_epithelial(191;0.149)|Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.213)														---	---	---	---
SETD3	84193	broad.mit.edu	37	14	99872775	99872775	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:99872775delT	uc001ygc.2	-							NM_032233	NP_115609			SET domain containing 3 isoform a						peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|peptidyl-lysine trimethylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone methyltransferase activity (H3-K36 specific)|transcription coactivator activity				0		all_cancers(154;0.224)|all_epithelial(191;0.0644)|Melanoma(154;0.0866)																---	---	---	---
YY1	7528	broad.mit.edu	37	14	100744094	100744094	+	3'UTR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:100744094delA	uc001ygy.1	+	5					uc001ygz.1_5'Flank	NM_003403	NP_003394			YY1 transcription factor						cell differentiation|cellular response to UV|double-strand break repair via homologous recombination|negative regulation of transcription from RNA polymerase II promoter|response to UV-C|spermatogenesis	Ino80 complex|nuclear matrix|plasma membrane	four-way junction DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding				0		Melanoma(154;0.152)																---	---	---	---
WARS	7453	broad.mit.edu	37	14	100833386	100833386	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:100833386delA	uc001yhf.1	-						WARS_uc001yhg.1_Intron|WARS_uc001yhh.1_Intron|WARS_uc001yhi.1_Intron|WARS_uc001yhj.1_Intron|WARS_uc001yhk.1_Intron|WARS_uc001yhl.1_Intron|WARS_uc010twz.1_Intron	NM_173701	NP_776049			tryptophanyl-tRNA synthetase isoform a						angiogenesis|negative regulation of cell proliferation|regulation of angiogenesis|tryptophanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|protein binding|tryptophan-tRNA ligase activity			breast(1)	1		all_cancers(154;0.00223)|all_lung(585;2.48e-06)|all_epithelial(191;0.000564)|Melanoma(154;0.152)			L-Tryptophan(DB00150)													---	---	---	---
PPP2R5C	5527	broad.mit.edu	37	14	102384071	102384071	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:102384071delG	uc001yko.2	+						PPP2R5C_uc010txr.1_Intron|PPP2R5C_uc001ykk.2_Intron|PPP2R5C_uc001ykp.2_Intron	NM_002719	NP_002710			gamma isoform of regulatory subunit B56, protein						DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|negative regulation of cell proliferation|proteasomal ubiquitin-dependent protein catabolic process|signal transduction	chromosome, centromeric region|nucleus|protein phosphatase type 2A complex	protein binding|protein binding|protein phosphatase type 2A regulator activity|protein phosphatase type 2A regulator activity			ovary(1)|breast(1)	2																		---	---	---	---
DYNC1H1	1778	broad.mit.edu	37	14	102472436	102472436	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:102472436delC	uc001yks.2	+	27	5809	c.5645delC	c.(5644-5646)ACCfs	p.T1882fs		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	1882	AAA 1 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10																		---	---	---	---
DYNC1H1	1778	broad.mit.edu	37	14	102489436	102489437	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:102489436_102489437insA	uc001yks.2	+						DYNC1H1_uc001ykt.1_3'UTR	NM_001376	NP_001367			cytoplasmic dynein 1 heavy chain 1						cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10																		---	---	---	---
HSP90AA1	3320	broad.mit.edu	37	14	102548312	102548312	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:102548312delA	uc001yku.3	-						HSP90AA1_uc001ykv.3_Intron	NM_005348	NP_005339			heat shock 90kDa protein 1, alpha isoform 2						axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			ovary(2)|central_nervous_system(2)|prostate(1)|lung(1)|breast(1)	7					Rifabutin(DB00615)													---	---	---	---
RCOR1	23186	broad.mit.edu	37	14	103177354	103177354	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:103177354delT	uc001ymb.2	+							NM_015156	NP_055971			REST corepressor 1						blood coagulation|histone H4 deacetylation|interspecies interaction between organisms	transcriptional repressor complex	protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription regulatory region DNA binding			ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	14	103615778	103615778	+	IGR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:103615778delA								TNFAIP2 (12002 upstream) : EIF5 (184715 downstream)																																			---	---	---	---
EIF5	1983	broad.mit.edu	37	14	103804651	103804651	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:103804651delT	uc001ymq.2	+						EIF5_uc001ymr.2_Intron|EIF5_uc001yms.2_Intron|EIF5_uc001ymt.2_Intron|EIF5_uc001ymu.2_Intron	NM_001969	NP_001960			eukaryotic translation initiation factor 5						regulation of translational initiation|RNA metabolic process	cytosol	GTP binding|GTPase activity|translation initiation factor activity			pancreas(1)|breast(1)|skin(1)	3		Melanoma(154;0.155)	Epithelial(46;0.182)															---	---	---	---
AHNAK2	113146	broad.mit.edu	37	14	105406621	105406621	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:105406621delC	uc010axc.1	-	7	15287	c.15167delG	c.(15166-15168)GGTfs	p.G5056fs	AHNAK2_uc001ypx.2_Frame_Shift_Del_p.G4956fs	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	5056						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)															---	---	---	---
AHNAK2	113146	broad.mit.edu	37	14	105419812	105419812	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:105419812delT	uc010axc.1	-	7	2096	c.1976delA	c.(1975-1977)AAGfs	p.K659fs	AHNAK2_uc001ypx.2_Frame_Shift_Del_p.K559fs	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	659						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)															---	---	---	---
JAG2	3714	broad.mit.edu	37	14	105618263	105618263	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:105618263delC	uc001yqg.2	-						JAG2_uc001yqf.2_5'Flank|JAG2_uc001yqh.2_Intron	NM_002226	NP_002217			jagged 2 isoform a precursor						auditory receptor cell fate commitment|cell communication|cell cycle|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation|spermatogenesis|thymic T cell selection	integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding			lung(3)|breast(2)	5		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)														---	---	---	---
PACS2	23241	broad.mit.edu	37	14	105818792	105818794	+	In_Frame_Del	DEL	CTT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:105818792_105818794delCTT	uc001yqt.2	+	3	460_462	c.285_287delCTT	c.(283-288)ACCTTC>ACC	p.F96del	PACS2_uc001yqs.2_In_Frame_Del_p.F29del|PACS2_uc001yqv.2_In_Frame_Del_p.F96del|PACS2_uc001yqu.2_In_Frame_Del_p.F96del	NM_015197	NP_056012	Q86VP3	PACS2_HUMAN	phosphofurin acidic cluster sorting protein 2	96					apoptosis|interspecies interaction between organisms	endoplasmic reticulum lumen|mitochondrion				pancreas(1)	1		all_cancers(154;0.0351)|all_epithelial(191;0.153)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)|Epithelial(46;0.036)	Epithelial(152;0.138)												OREG0022968	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
Unknown	0	broad.mit.edu	37	15	20476715	20476715	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:20476715delT								None (None upstream) : GOLGA6L6 (260379 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	15	20710570	20710570	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:20710570delA	uc001ytg.2	-						uc010tyx.1_Intron|uc001yth.3_Intron					RecName: Full=Putative HERC2-like protein 3;																														---	---	---	---
NF1P1	440225	broad.mit.edu	37	15	22146339	22146340	+	5'Flank	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:22146339_22146340insT	uc010tzs.1	-											Human NF1-related locus DNA in A9 mouse DNA background.												0																		---	---	---	---
TUBGCP5	114791	broad.mit.edu	37	15	22848452	22848452	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:22848452delA	uc001yur.3	+						TUBGCP5_uc001yuq.2_Intron|TUBGCP5_uc010axz.1_5'Flank	NM_052903	NP_443135			tubulin, gamma complex associated protein 5						G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			skin(1)	1		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)														---	---	---	---
HERC2P2	400322	broad.mit.edu	37	15	23331163	23331164	+	Intron	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:23331163_23331164delAA	uc001yvr.2	-						HERC2P2_uc010ayf.1_Intron					RecName: Full=Putative HERC2-like protein 3;												0																		---	---	---	---
SNRPN	6638	broad.mit.edu	37	15	25207157	25207157	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:25207157delA	uc001ywp.1	+						SNRPN_uc001ywq.1_Intron|SNRPN_uc001ywr.1_Intron|SNRPN_uc001yws.1_Intron|SNRPN_uc001ywt.1_Intron|SNURF_uc001ywu.2_Intron|SNRPN_uc001ywv.1_Intron|SNRPN_uc001yww.1_Intron|SNRPN_uc001ywx.1_Intron|SNRPN_uc001ywz.1_Intron|PAR-SN_uc001yxa.1_Intron|SNRPN_uc001ywy.1_Intron	NM_022807	NP_073718			small nuclear ribonucleoprotein polypeptide N						RNA splicing	small nuclear ribonucleoprotein complex|spliceosomal complex	identical protein binding|RNA binding			ovary(1)	1		all_cancers(20;9.33e-22)|Breast(32;0.000625)		all cancers(64;3.38e-08)|Epithelial(43;3.45e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000207)|GBM - Glioblastoma multiforme(186;0.125)										Prader-Willi_syndrome				---	---	---	---
SNRPN	6638	broad.mit.edu	37	15	25222784	25222784	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:25222784delA	uc001ywp.1	+						SNRPN_uc001ywq.1_Intron|SNRPN_uc001ywr.1_Intron|SNRPN_uc001yws.1_Intron|SNRPN_uc001ywt.1_Intron|SNRPN_uc001ywv.1_Intron|SNRPN_uc001yww.1_Intron|SNRPN_uc001ywx.1_Intron|SNRPN_uc001ywz.1_Intron|PAR-SN_uc001yxa.1_Intron|SNRPN_uc001ywy.1_Intron	NM_022807	NP_073718			small nuclear ribonucleoprotein polypeptide N						RNA splicing	small nuclear ribonucleoprotein complex|spliceosomal complex	identical protein binding|RNA binding			ovary(1)	1		all_cancers(20;9.33e-22)|Breast(32;0.000625)		all cancers(64;3.38e-08)|Epithelial(43;3.45e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000207)|GBM - Glioblastoma multiforme(186;0.125)										Prader-Willi_syndrome				---	---	---	---
SNORD116-4	100033416	broad.mit.edu	37	15	25310193	25310193	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:25310193delA	uc001yxh.1	+						SNORD116-4_uc001yxm.1_Intron|IPW_uc001yxn.3_Intron|SNORD116-2_uc001yxp.2_RNA|SNORD116-5_uc001yxq.2_5'Flank					Homo sapiens clone kid4 SNURF-SNRPN mRNA, downstream untranslated exons, alternatively spliced.												0																		---	---	---	---
Unknown	0	broad.mit.edu	37	15	25483319	25483319	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:25483319delG	uc001zae.2	+						SNORD115-38_uc001zag.1_5'Flank					Homo sapiens clone Rt-16 SNURF-SNRPN mRNA, downstream untranslated exons, alternatively spliced.																														---	---	---	---
OCA2	4948	broad.mit.edu	37	15	28228736	28228737	+	Intron	DEL	CA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:28228736_28228737delCA	uc001zbh.3	-						OCA2_uc010ayv.2_Intron	NM_000275	NP_000266			oculocutaneous albinism II						eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)										Oculocutaneous_Albinism				---	---	---	---
Unknown	0	broad.mit.edu	37	15	28751705	28751706	+	IGR	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:28751705_28751706delTT								GOLGA8G (114534 upstream) : WHAMML2 (231023 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	15	29078591	29078591	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:29078591delT	uc001zcj.2	+											Homo sapiens, Similar to hect domain and RLD 2, clone IMAGE:4581928, mRNA.																														---	---	---	---
ARHGAP11A	9824	broad.mit.edu	37	15	32915923	32915923	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:32915923delT	uc001zgy.1	+						ARHGAP11A_uc010ubw.1_Intron|ARHGAP11A_uc001zgw.2_Intron|ARHGAP11A_uc001zgx.2_Intron|ARHGAP11A_uc010ubx.1_Intron	NM_014783	NP_055598			Rho GTPase activating protein 11A isoform 1						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			skin(3)|breast(2)|urinary_tract(1)	6		all_lung(180;1.3e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)														---	---	---	---
FMN1	342184	broad.mit.edu	37	15	33066565	33066565	+	Intron	DEL	A	-	-	rs76684755		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:33066565delA	uc001zhf.3	-							NM_001103184	NP_001096654			formin 1						actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			ovary(1)	1		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)														---	---	---	---
RYR3	6263	broad.mit.edu	37	15	33895220	33895221	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:33895220_33895221insT	uc001zhi.2	+						RYR3_uc010bar.2_Intron	NM_001036	NP_001027			ryanodine receptor 3						cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)														---	---	---	---
RYR3	6263	broad.mit.edu	37	15	33923503	33923503	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:33923503delT	uc001zhi.2	+						RYR3_uc010bar.2_Intron	NM_001036	NP_001027			ryanodine receptor 3						cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)														---	---	---	---
C15orf29	79768	broad.mit.edu	37	15	34445168	34445168	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:34445168delT	uc001zhp.2	-	4	421	c.261delA	c.(259-261)AAAfs	p.K87fs	C15orf29_uc010ubz.1_5'UTR|C15orf29_uc010uca.1_Frame_Shift_Del_p.K87fs	NM_024713	NP_078989	Q9H079	CO029_HUMAN	hypothetical protein LOC79768	87						nucleolus				ovary(1)	1		all_lung(180;1.86e-06)		all cancers(64;5.49e-18)|GBM - Glioblastoma multiforme(113;8.91e-07)|BRCA - Breast invasive adenocarcinoma(123;0.026)|Lung(196;0.229)														---	---	---	---
MEIS2	4212	broad.mit.edu	37	15	37188776	37188778	+	Intron	DEL	TGA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:37188776_37188778delTGA	uc001zjr.2	-						MEIS2_uc001zjl.2_Intron|MEIS2_uc010ucj.1_Intron|MEIS2_uc001zjm.2_Intron|MEIS2_uc001zjn.2_Intron|MEIS2_uc001zjo.2_Intron|MEIS2_uc001zjp.2_Intron|MEIS2_uc001zjs.2_Intron|MEIS2_uc001zju.2_Intron|MEIS2_uc001zjt.2_Intron|MEIS2_uc001zjj.2_Intron|MEIS2_uc001zjk.2_Intron	NM_170675	NP_733775			Meis homeobox 2 isoform c						negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)	2		all_epithelial(112;9.77e-14)|Lung NSC(122;1.42e-09)|all_lung(180;2.2e-08)|Ovarian(310;0.134)|Melanoma(134;0.155)		all cancers(64;9.33e-21)|GBM - Glioblastoma multiforme(113;1.71e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0288)														---	---	---	---
BUB1B	701	broad.mit.edu	37	15	40477243	40477243	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:40477243delT	uc001zkx.3	+						BUB1B_uc010ucl.1_Intron	NM_001211	NP_001202			budding uninhibited by benzimidazoles 1 beta						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|kidney(1)	4		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)				Mis|N|F|S			rhabdomyosarcoma			Mosaic_Variegated_Aneuploidy_Syndrome				---	---	---	---
Unknown	0	broad.mit.edu	37	15	41026744	41026744	+	IGR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:41026744delA								RAD51 (2390 upstream) : FAM82A2 (1342 downstream)																																			---	---	---	---
SPINT1	6692	broad.mit.edu	37	15	41137333	41137333	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:41137333delT	uc001zna.2	+						SPINT1_uc001znb.2_Intron|SPINT1_uc001znc.2_Intron|SPINT1_uc010ucs.1_Intron	NM_181642	NP_857593			serine peptidase inhibitor, Kunitz type 1							extracellular region|membrane fraction	protein binding|serine-type endopeptidase inhibitor activity			ovary(1)	1		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.91e-05)|COAD - Colon adenocarcinoma(120;0.153)|BRCA - Breast invasive adenocarcinoma(123;0.166)														---	---	---	---
SPINT1	6692	broad.mit.edu	37	15	41148082	41148082	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:41148082delC	uc001zna.2	+						SPINT1_uc001znb.2_Intron|SPINT1_uc001znc.2_Intron|SPINT1_uc010ucs.1_Intron	NM_181642	NP_857593			serine peptidase inhibitor, Kunitz type 1							extracellular region|membrane fraction	protein binding|serine-type endopeptidase inhibitor activity			ovary(1)	1		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.91e-05)|COAD - Colon adenocarcinoma(120;0.153)|BRCA - Breast invasive adenocarcinoma(123;0.166)														---	---	---	---
EXD1	161829	broad.mit.edu	37	15	41508186	41508186	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:41508186delT	uc001znk.2	-						EXD1_uc010ucv.1_Intron	NM_152596	NP_689809			exonuclease 3'-5' domain containing 1						nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			ovary(1)	1																		---	---	---	---
RTF1	23168	broad.mit.edu	37	15	41770764	41770764	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:41770764delA	uc001zny.2	+	15	1771	c.1759delA	c.(1759-1761)AAAfs	p.K587fs		NM_015138	NP_055953	Q92541	RTF1_HUMAN	Paf1/RNA polymerase II complex component	587					histone modification|regulation of transcription, DNA-dependent|transcription initiation, DNA-dependent	nucleoplasm	protein binding|single-stranded DNA binding			ovary(2)	2		all_cancers(109;1.79e-19)|all_epithelial(112;8.18e-17)|Lung NSC(122;3.16e-11)|all_lung(180;8.14e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;1.15e-16)|GBM - Glioblastoma multiforme(113;1.81e-06)|BRCA - Breast invasive adenocarcinoma(123;0.119)														---	---	---	---
SPTBN5	51332	broad.mit.edu	37	15	42144977	42144979	+	Intron	DEL	GGC	-	-	rs111432071		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:42144977_42144979delGGC	uc001zos.2	-							NM_016642	NP_057726			spectrin, beta, non-erythrocytic 5						actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)														---	---	---	---
SPTBN5	51332	broad.mit.edu	37	15	42168855	42168855	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:42168855delG	uc001zos.2	-							NM_016642	NP_057726			spectrin, beta, non-erythrocytic 5						actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)														---	---	---	---
MAP1A	4130	broad.mit.edu	37	15	43819801	43819801	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:43819801delC	uc001zrt.2	+	4	6597	c.6130delC	c.(6130-6132)CCCfs	p.P2044fs		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2044						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)													---	---	---	---
Unknown	0	broad.mit.edu	37	15	44023811	44023811	+	5'Flank	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:44023811delT	uc010uec.1	-											Homo sapiens cDNA FLJ16411 fis, clone BRACE2016362.																														---	---	---	---
WDR76	79968	broad.mit.edu	37	15	44143247	44143247	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:44143247delT	uc001zti.1	+							NM_024908	NP_079184			WD repeat domain 76												0		all_cancers(109;3.26e-11)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.61e-06)|all_lung(180;1.5e-05)|Melanoma(134;0.0417)		all cancers(107;3.78e-21)|GBM - Glioblastoma multiforme(94;5.04e-07)														---	---	---	---
CTDSPL2	51496	broad.mit.edu	37	15	44811330	44811330	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:44811330delT	uc001ztr.2	+						CTDSPL2_uc001zts.2_Intron|CTDSPL2_uc001ztt.2_Intron|CTDSPL2_uc010bdv.2_Intron	NM_016396	NP_057480			CTD (carboxy-terminal domain, RNA polymerase II,								phosphoprotein phosphatase activity				0		all_cancers(109;4.36e-14)|all_epithelial(112;9.8e-12)|Lung NSC(122;1.66e-07)|all_lung(180;1.47e-06)|Melanoma(134;0.0122)		all cancers(107;1.02e-20)|GBM - Glioblastoma multiforme(94;1.49e-06)|COAD - Colon adenocarcinoma(120;0.0857)|Colorectal(105;0.0905)														---	---	---	---
SPG11	80208	broad.mit.edu	37	15	44898345	44898345	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:44898345delA	uc001ztx.2	-						SPG11_uc010ueh.1_Intron|SPG11_uc010uei.1_Intron	NM_025137	NP_079413			spatacsin isoform 1						cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)														---	---	---	---
SPG11	80208	broad.mit.edu	37	15	44949207	44949207	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:44949207delA	uc001ztx.2	-						SPG11_uc010ueh.1_Intron|SPG11_uc010uei.1_Intron|SPG11_uc001zua.1_Intron	NM_025137	NP_079413			spatacsin isoform 1						cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)														---	---	---	---
SLC28A2	9153	broad.mit.edu	37	15	45561372	45561372	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:45561372delA	uc001zva.2	+							NM_004212	NP_004203			solute carrier family 28 (sodium-coupled						nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding|nucleoside:sodium symporter activity|purine nucleoside transmembrane transporter activity			ovary(4)	4		all_cancers(109;8.53e-07)|all_epithelial(112;1.39e-05)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.77e-16)|GBM - Glioblastoma multiforme(94;2.71e-06)														---	---	---	---
SQRDL	58472	broad.mit.edu	37	15	45981075	45981075	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:45981075delT	uc001zvt.2	+						SQRDL_uc001zvu.2_Intron|SQRDL_uc001zvv.2_Intron	NM_021199	NP_067022			sulfide dehydrogenase like precursor								oxidoreductase activity			ovary(1)	1		Lung NSC(122;0.000117)|all_lung(180;0.000737)|Melanoma(134;0.0417)		all cancers(107;5.89e-18)|GBM - Glioblastoma multiforme(94;1.21e-06)|COAD - Colon adenocarcinoma(120;0.17)|Colorectal(133;0.188)														---	---	---	---
DUT	1854	broad.mit.edu	37	15	48634180	48634180	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:48634180delA	uc001zws.2	+						DUT_uc001zwt.2_Intron|DUT_uc001zwu.2_Intron|DUT_uc001zwv.2_3'UTR|DUT_uc001zww.2_Intron	NM_001025248	NP_001020419			deoxyuridine triphosphatase isoform 1 precursor						DNA replication|dUTP metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside biosynthetic process	mitochondrion|nucleoplasm	dUTP diphosphatase activity|protein binding				0		all_lung(180;0.00265)		all cancers(107;2.66e-09)|GBM - Glioblastoma multiforme(94;6.76e-07)									Modulation_of_nucleotide_pools					---	---	---	---
CEP152	22995	broad.mit.edu	37	15	49059021	49059021	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:49059021delA	uc001zwy.2	-						CEP152_uc001zwz.2_Intron|CEP152_uc001zxa.1_Intron	NM_014985	NP_055800			centrosomal protein 152kDa						centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			lung(2)	2		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)														---	---	---	---
C15orf33	196951	broad.mit.edu	37	15	49658246	49658246	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:49658246delT	uc001zxl.2	-							NM_152647	NP_689860			hypothetical protein LOC196951											ovary(1)	1		all_lung(180;0.00187)		all cancers(107;3.45e-08)|GBM - Glioblastoma multiforme(94;0.000124)														---	---	---	---
USP8	9101	broad.mit.edu	37	15	50769444	50769444	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:50769444delA	uc001zym.3	+						USP8_uc001zyk.1_Intron|USP8_uc001zyl.3_Intron|USP8_uc001zyn.3_Intron|USP8_uc010ufh.1_Intron|USP8_uc010bev.1_Intron	NM_001128611	NP_001122083			ubiquitin specific peptidase 8						cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)|central_nervous_system(1)	2				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)														---	---	---	---
DMXL2	23312	broad.mit.edu	37	15	51829108	51829108	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:51829108delA	uc002abf.2	-						DMXL2_uc010ufy.1_Intron|DMXL2_uc010bfa.2_Intron	NM_015263	NP_056078			Dmx-like 2							cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)														---	---	---	---
LEO1	123169	broad.mit.edu	37	15	52239785	52239785	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:52239785delT	uc002abo.2	-						LEO1_uc010bfd.2_Intron	NM_138792	NP_620147			Leo1, Paf1/RNA polymerase II complex component,						histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding				0				all cancers(107;0.00264)														---	---	---	---
WDR72	256764	broad.mit.edu	37	15	53889664	53889664	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:53889664delT	uc002acj.2	-							NM_182758	NP_877435			WD repeat domain 72											lung(1)|skin(1)	2				all cancers(107;0.0511)														---	---	---	---
WDR72	256764	broad.mit.edu	37	15	54003203	54003203	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:54003203delT	uc002acj.2	-						WDR72_uc010bfi.1_Intron	NM_182758	NP_877435			WD repeat domain 72											lung(1)|skin(1)	2				all cancers(107;0.0511)														---	---	---	---
PRTG	283659	broad.mit.edu	37	15	55930705	55930705	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:55930705delT	uc002adg.2	-							NM_173814	NP_776175			protogenin precursor						multicellular organismal development	integral to membrane				large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)														---	---	---	---
FAM81A	145773	broad.mit.edu	37	15	59806474	59806474	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:59806474delT	uc002agc.2	+							NM_152450	NP_689663			hypothetical protein LOC145773											ovary(1)	1																		---	---	---	---
BNIP2	663	broad.mit.edu	37	15	59963289	59963289	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:59963289delA	uc010uhc.1	-						BNIP2_uc002agi.3_5'Flank|BNIP2_uc010uhb.1_Intron	NM_004330	NP_004321			BCL2/adenovirus E1B 19kD interacting protein 2						anti-apoptosis|apoptosis|positive regulation of muscle cell differentiation	nuclear envelope|perinuclear region of cytoplasm	calcium ion binding|GTPase activator activity|protein binding			ovary(1)	1																		---	---	---	---
VPS13C	54832	broad.mit.edu	37	15	62265442	62265443	+	Intron	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:62265442_62265443delAA	uc002agz.2	-						VPS13C_uc002aha.2_Intron|VPS13C_uc002ahb.1_Intron|VPS13C_uc002ahc.1_Intron	NM_020821	NP_065872			vacuolar protein sorting 13C protein isoform 2A						protein localization					ovary(2)	2																		---	---	---	---
HERC1	8925	broad.mit.edu	37	15	64015557	64015557	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:64015557delA	uc002amp.2	-						HERC1_uc010uil.1_Intron	NM_003922	NP_003913			hect domain and RCC1-like domain 1						protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19																		---	---	---	---
SNX1	6642	broad.mit.edu	37	15	64419305	64419306	+	Intron	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:64419305_64419306delAA	uc002amv.2	+						SNX1_uc010bgv.2_Intron|SNX1_uc010uio.1_Intron|SNX1_uc002amw.2_Intron|SNX1_uc002amx.2_Intron|SNX1_uc002amy.2_Intron|SNX1_uc010bgw.2_Intron	NM_003099	NP_003090			sorting nexin 1 isoform a						cell communication|early endosome to Golgi transport|endocytosis|intracellular protein transport	early endosome membrane|Golgi apparatus	phosphatidylinositol binding|protein binding|protein transporter activity				0																		---	---	---	---
TRIP4	9325	broad.mit.edu	37	15	64702168	64702168	+	Intron	DEL	G	-	-	rs10468032	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:64702168delG	uc002anm.2	+							NM_016213	NP_057297			thyroid hormone receptor interactor 4						positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	ligand-dependent nuclear receptor binding|transcription coactivator activity|zinc ion binding			ovary(1)|kidney(1)|skin(1)	3																		---	---	---	---
IGDCC3	9543	broad.mit.edu	37	15	65621335	65621335	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:65621335delG	uc002aos.2	-	14	2609	c.2357delC	c.(2356-2358)CCAfs	p.P786fs	IGDCC3_uc002aor.1_Frame_Shift_Del_p.P72fs	NM_004884	NP_004875	Q8IVU1	IGDC3_HUMAN	putative neuronal cell adhesion molecule	786	Poly-Pro.|Cytoplasmic (Potential).									ovary(3)	3																		---	---	---	---
DENND4A	10260	broad.mit.edu	37	15	65957481	65957481	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:65957481delA	uc002aph.2	-						DENND4A_uc002api.2_Intron	NM_005848	NP_005839			DENN/MADD domain containing 4A isoform 2						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4																		---	---	---	---
LCTL	197021	broad.mit.edu	37	15	66840638	66840639	+	3'UTR	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:66840638_66840639delTT	uc002aqc.2	-	13					LCTL_uc002aqd.3_3'UTR|LCTL_uc010bhw.2_3'UTR|ZWILCH_uc002aqb.2_Intron|ZWILCH_uc002aqa.2_Intron|ZWILCH_uc010bhv.2_Intron	NM_207338	NP_997221			lactase-like precursor						carbohydrate metabolic process	endoplasmic reticulum membrane|integral to membrane	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(2)	2																		---	---	---	---
AAGAB	79719	broad.mit.edu	37	15	67528577	67528577	+	Intron	DEL	A	-	-	rs35008448		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:67528577delA	uc002aqk.3	-						AAGAB_uc002aql.2_Intron|AAGAB_uc010uju.1_Intron	NM_024666	NP_078942			alpha- and gamma-adaptin-binding protein p34						protein transport	cytoplasm					0																		---	---	---	---
IQCH	64799	broad.mit.edu	37	15	67709169	67709169	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:67709169delT	uc002aqo.1	+						IQCH_uc002aqq.1_Intron|IQCH_uc002aqp.1_Intron|uc002aqr.1_Intron	NM_001031715	NP_001026885			IQ motif containing H isoform 1											skin(3)|ovary(1)	4				Colorectal(3;0.0856)														---	---	---	---
PIAS1	8554	broad.mit.edu	37	15	68469011	68469011	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:68469011delA	uc002aqz.2	+						PIAS1_uc002ara.2_Intron	NM_016166	NP_057250			protein inhibitor of activated STAT, 1						androgen receptor signaling pathway|interferon-gamma-mediated signaling pathway|JAK-STAT cascade|positive regulation of protein sumoylation|positive regulation of transcription, DNA-dependent|regulation of interferon-gamma-mediated signaling pathway|transcription, DNA-dependent	nuclear speck	androgen receptor binding|DNA binding|enzyme binding|SUMO ligase activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)	2																		---	---	---	---
NOX5	79400	broad.mit.edu	37	15	69320455	69320455	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:69320455delC	uc002ars.1	+						NOX5_uc002arp.1_Intron|NOX5_uc002arq.1_Intron|NOX5_uc010bid.1_Intron|NOX5_uc002arr.1_Intron|NOX5_uc010bie.1_Intron	NM_024505	NP_078781			NADPH oxidase, EF-hand calcium binding domain 5						angiogenesis|angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(1)|pancreas(1)	2																		---	---	---	---
THSD4	79875	broad.mit.edu	37	15	72041049	72041049	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:72041049delA	uc002atb.1	+						THSD4_uc002ate.2_Intron	NM_024817	NP_079093			thrombospondin, type I, domain containing 4							proteinaceous extracellular matrix	metalloendopeptidase activity			ovary(2)	2																		---	---	---	---
MYO9A	4649	broad.mit.edu	37	15	72141155	72141155	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:72141155delT	uc002atl.3	-						MYO9A_uc002atj.2_Intron|MYO9A_uc002atk.2_Intron	NM_006901	NP_008832			myosin IXA						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3																		---	---	---	---
CD276	80381	broad.mit.edu	37	15	74005152	74005153	+	Intron	DEL	CA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:74005152_74005153delCA	uc002avv.1	+						CD276_uc002avw.1_Intron|CD276_uc010ulb.1_Intron|CD276_uc002avx.2_Intron	NM_001024736	NP_001019907			CD276 antigen isoform a						cell proliferation|immune response|positive regulation of interferon-gamma biosynthetic process|positive regulation of T cell proliferation|regulation of immune response|T cell activation	external side of plasma membrane|integral to membrane	receptor binding			skin(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	15	75541371	75541372	+	IGR	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:75541371_75541372delTT								C15orf39 (36863 upstream) : GOLGA6C (9527 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	15	75541854	75541854	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:75541854delT								C15orf39 (37346 upstream) : GOLGA6C (9045 downstream)																																			---	---	---	---
SIN3A	25942	broad.mit.edu	37	15	75676898	75676898	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:75676898delG	uc002bai.2	-						SIN3A_uc002baj.2_Intron|SIN3A_uc010uml.1_Intron	NM_015477	NP_056292			transcriptional co-repressor Sin3A						blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			skin(3)|ovary(1)|lung(1)	5																		---	---	---	---
SCAPER	49855	broad.mit.edu	37	15	77096991	77096991	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:77096991delA	uc002bby.2	-						SCAPER_uc002bbx.2_Intron|SCAPER_uc002bbz.1_Intron|SCAPER_uc002bca.1_Intron|SCAPER_uc002bcb.1_Intron|SCAPER_uc002bcc.1_Intron	NM_020843	NP_065894			S-phase cyclin A-associated protein in the ER							endoplasmic reticulum|nucleus	zinc ion binding			large_intestine(1)|lung(1)|ovary(1)	3																		---	---	---	---
CIB2	10518	broad.mit.edu	37	15	78397504	78397504	+	3'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:78397504delT	uc002bdb.1	-	6					CIB2_uc002bdc.1_3'UTR	NM_006383	NP_006374			DNA-dependent protein kinase catalytic								calcium ion binding				0																		---	---	---	---
ACSBG1	23205	broad.mit.edu	37	15	78470819	78470819	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:78470819delT	uc002bdh.2	-						ACSBG1_uc010umw.1_Intron|ACSBG1_uc010umx.1_Intron	NM_015162	NP_055977			lipidosin						long-chain fatty acid metabolic process|myelination|very long-chain fatty acid metabolic process	cytoplasmic membrane-bounded vesicle|endoplasmic reticulum|microsome	ATP binding|long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity			ovary(1)	1																		---	---	---	---
IREB2	3658	broad.mit.edu	37	15	78758544	78758544	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:78758544delT	uc002bdr.2	+						IREB2_uc010unb.1_Intron|IREB2_uc002bdq.2_Intron	NM_004136	NP_004127			iron-responsive element binding protein 2								4 iron, 4 sulfur cluster binding|metal ion binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (272;0.232)														---	---	---	---
AP3B2	8120	broad.mit.edu	37	15	83360356	83360356	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:83360356delA	uc010uoh.1	-						AP3B2_uc010uoi.1_Intron|AP3B2_uc010uoj.1_Intron|AP3B2_uc010uok.1_Intron	NM_004644	NP_004635			adaptor-related protein complex 3, beta 2						endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			ovary(3)|breast(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.229)															---	---	---	---
C15orf40	123207	broad.mit.edu	37	15	83658583	83658583	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:83658583delT	uc010uon.1	-						FAM103A1_uc002bjl.1_Intron	NM_001160116	NP_001153588			hypothetical protein LOC123207 isoform e											skin(1)	1																		---	---	---	---
ADAMTSL3	57188	broad.mit.edu	37	15	84651007	84651007	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:84651007delT	uc002bjz.3	+						ADAMTSL3_uc010bmt.1_Intron|ADAMTSL3_uc010bmu.1_Intron	NM_207517	NP_997400			ADAMTS-like 3 precursor							proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)															---	---	---	---
Unknown	0	broad.mit.edu	37	15	84773625	84773625	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:84773625delT								ADAMTSL3 (65034 upstream) : LOC388152 (93975 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	15	85785266	85785266	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:85785266delT	uc010upj.1	+							NM_198181	NP_937824			golgi autoantigen, golgin subfamily a, 6D-like																														---	---	---	---
AGBL1	123624	broad.mit.edu	37	15	87089453	87089454	+	Intron	DEL	TT	-	-	rs66611676		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:87089453_87089454delTT	uc002blz.1	+							NM_152336	NP_689549			ATP/GTP binding protein-like 1						C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0																		---	---	---	---
NTRK3	4916	broad.mit.edu	37	15	88423337	88423337	+	Intron	DEL	T	-	-	rs71851481		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:88423337delT	uc002bme.1	-						NTRK3_uc002bmh.2_Intron|NTRK3_uc002bmf.1_Intron	NM_001012338	NP_001012338			neurotrophic tyrosine kinase, receptor, type 3						transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)					T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			---	---	---	---
ABHD2	11057	broad.mit.edu	37	15	89679670	89679670	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:89679670delA	uc002bnj.2	+						ABHD2_uc002bnk.2_Intron	NM_007011	NP_008942			alpha/beta hydrolase domain containing protein							integral to membrane	carboxylesterase activity			ovary(1)|lung(1)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)																	---	---	---	---
FANCI	55215	broad.mit.edu	37	15	89805157	89805157	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:89805157delA	uc010bnp.1	+						FANCI_uc002bnm.1_Intron|FANCI_uc002bnn.1_Intron|FANCI_uc002bno.2_Intron|FANCI_uc002bnp.1_5'Flank	NM_001113378	NP_001106849			Fanconi anemia, complementation group I isoform						cell cycle|DNA repair	nucleoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)												Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				---	---	---	---
Unknown	0	broad.mit.edu	37	15	90825347	90825347	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:90825347delT								TTLL13 (9904 upstream) : GABARAPL3 (64418 downstream)																																			---	---	---	---
CRTC3	64784	broad.mit.edu	37	15	91161098	91161098	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:91161098delT	uc002bpp.2	+						CRTC3_uc002bpo.2_Intron	NM_022769	NP_073606			transducer of regulated CREB protein 3 isoform						interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus			CRTC3/MAML2(26)	salivary_gland(26)|ovary(1)	27	Melanoma(11;0.00551)|Lung NSC(78;0.0931)|all_lung(78;0.163)		BRCA - Breast invasive adenocarcinoma(143;0.0745)					T	MAML2	salivary gland mucoepidermoid								---	---	---	---
BLM	641	broad.mit.edu	37	15	91308328	91308328	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:91308328delT	uc002bpr.2	+						BLM_uc010uqh.1_Intron|BLM_uc010uqi.1_Intron|BLM_uc010bnx.2_Intron|BLM_uc002bps.1_Intron	NM_000057	NP_000048			Bloom syndrome protein						double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			ovary(3)|skin(2)|breast(1)	6	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)					Mis|N|F			leukemia|lymphoma|skin squamous cell |other cancers		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Bloom_syndrome				---	---	---	---
LRRC28	123355	broad.mit.edu	37	15	99903128	99903128	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:99903128delA	uc002bva.1	+						LRRC28_uc010urs.1_Intron|LRRC28_uc002bvb.1_Intron|LRRC28_uc010urt.1_Intron|LRRC28_uc002bvc.1_Intron|LRRC28_uc010uru.1_Intron|LRRC28_uc002bvd.1_Intron	NM_144598	NP_653199			leucine rich repeat containing 28												0	Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00778)|Medulloblastoma(229;0.163)		OV - Ovarian serous cystadenocarcinoma(32;0.00106)															---	---	---	---
ALDH1A3	220	broad.mit.edu	37	15	101432912	101432912	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:101432912delC	uc002bwn.3	+						ALDH1A3_uc010bpb.2_Intron	NM_000693	NP_000684			aldehyde dehydrogenase 1A3						retinal metabolic process	cytoplasm	aldehyde dehydrogenase|protein homodimerization activity			central_nervous_system(2)|lung(1)|pancreas(1)	4	Lung NSC(78;0.00144)|all_lung(78;0.0018)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)		NADH(DB00157)|Vitamin A(DB00162)													---	---	---	---
LUC7L	55692	broad.mit.edu	37	16	240581	240581	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:240581delA	uc002cgc.1	-						LUC7L_uc002cga.1_Intron|LUC7L_uc002cgd.1_Intron|LUC7L_uc002cge.1_Intron|LUC7L_uc002cgb.1_Intron	NM_201412	NP_958815			LUC7-like isoform b								metal ion binding			central_nervous_system(1)	1		all_cancers(16;1.1e-06)|all_epithelial(16;2.71e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.0138)|all_lung(18;0.0306)																---	---	---	---
TMEM8A	58986	broad.mit.edu	37	16	426284	426285	+	Frame_Shift_Ins	INS	-	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:426284_426285insC	uc002cgu.3	-	6	1204_1205	c.1075_1076insG	c.(1075-1077)GAGfs	p.E359fs	TMEM8A_uc002cgv.3_Frame_Shift_Ins_p.E166fs	NM_021259	NP_067082	Q9HCN3	TMM8A_HUMAN	transmembrane protein 8 (five membrane-spanning	359	Extracellular (Potential).				cell adhesion	integral to plasma membrane				central_nervous_system(2)|pancreas(1)	3																		---	---	---	---
CCDC78	124093	broad.mit.edu	37	16	774189	774189	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:774189delG	uc002cjg.2	-	10	1076	c.970delC	c.(970-972)CAAfs	p.Q324fs	CCDC78_uc002cjf.2_Frame_Shift_Del_p.Q173fs|CCDC78_uc002cji.3_3'UTR|CCDC78_uc002cjj.3_3'UTR|CCDC78_uc002cjh.2_Frame_Shift_Del_p.Q83fs|HAGHL_uc002cjl.1_5'Flank|HAGHL_uc002cjm.1_5'Flank|HAGHL_uc002cjn.1_5'Flank	NM_001031737	NP_001026907	A2IDD5	CCD78_HUMAN	coiled-coil domain containing 78	324										central_nervous_system(1)	1		Hepatocellular(780;0.0218)																---	---	---	---
IGFALS	3483	broad.mit.edu	37	16	1842147	1842147	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:1842147delG	uc002cmy.2	-	2	353	c.272delC	c.(271-273)CCGfs	p.P91fs	IGFALS_uc010uvn.1_Frame_Shift_Del_p.P129fs|IGFALS_uc010uvo.1_5'UTR	NM_004970	NP_004961	P35858	ALS_HUMAN	insulin-like growth factor binding protein, acid	91	LRR 1.				cell adhesion|signal transduction	soluble fraction	insulin-like growth factor binding				0																		---	---	---	---
ABCA3	21	broad.mit.edu	37	16	2382818	2382818	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2382818delT	uc002cpy.1	-						ABCA3_uc010bsk.1_Intron|ABCA3_uc010bsl.1_Intron|ABCA3_uc002cpz.1_5'Flank	NM_001089	NP_001080			ATP-binding cassette, sub-family A member 3						response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)																---	---	---	---
SRRM2	23524	broad.mit.edu	37	16	2821014	2821014	+	3'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2821014delT	uc002crk.2	+	15						NM_016333	NP_057417			splicing coactivator subunit SRm300							Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4																		---	---	---	---
ZNF213	7760	broad.mit.edu	37	16	3188482	3188482	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3188482delC	uc010uws.1	+	3	910	c.463delC	c.(463-465)CCCfs	p.P155fs	ZNF213_uc002cud.2_RNA|ZNF213_uc010btf.2_3'UTR|ZNF213_uc010bth.2_Frame_Shift_Del_p.P155fs|ZNF213_uc010uwt.1_Frame_Shift_Del_p.P155fs	NM_004220	NP_004211	O14771	ZN213_HUMAN	zinc finger protein 213	155					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0																		---	---	---	---
ABAT	18	broad.mit.edu	37	16	8862471	8862471	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:8862471delA	uc002czc.3	+						ABAT_uc002czd.3_Intron|ABAT_uc010buh.2_Intron|ABAT_uc010bui.2_Intron	NM_020686	NP_065737			4-aminobutyrate aminotransferase precursor						behavioral response to cocaine|gamma-aminobutyric acid catabolic process|neurotransmitter catabolic process|neurotransmitter secretion	4-aminobutyrate transaminase complex|mitochondrial matrix	(S)-3-amino-2-methylpropionate transaminase activity|4-aminobutyrate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding|succinate-semialdehyde dehydrogenase binding			upper_aerodigestive_tract(1)	1					Divalproex sodium(DB00510)|Isoniazid(DB00951)|L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)|Tiagabine(DB00906)|Valproic Acid(DB00313)|Vigabatrin(DB01080)													---	---	---	---
PMM2	5373	broad.mit.edu	37	16	8906663	8906663	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:8906663delA	uc002czf.3	+						PMM2_uc010uyf.1_Intron|PMM2_uc010uyg.1_Intron|PMM2_uc010uyh.1_Intron|PMM2_uc010buj.2_Intron|PMM2_uc010uyi.1_Intron	NM_000303	NP_000294			phosphomannomutase 2						dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	phosphomannomutase activity			ovary(1)	1																		---	---	---	---
FAM18A	780776	broad.mit.edu	37	16	10867203	10867203	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:10867203delA	uc010buo.1	-	5	691	c.420delT	c.(418-420)TTTfs	p.F140fs	FAM18A_uc010uyr.1_RNA|FAM18A_uc010uys.1_RNA|FAM18A_uc010uyt.1_RNA|FAM18A_uc010bun.2_RNA|FAM18A_uc010uyu.1_RNA|FAM18A_uc002dad.3_RNA|FAM18A_uc002daf.1_RNA|FAM18A_uc002dae.1_Frame_Shift_Del_p.F76fs	NM_001079512	NP_001072980	A6NH52	FA18A_HUMAN	hypothetical protein LOC780776	140	Helical; (Potential).					integral to membrane					0																		---	---	---	---
Unknown	0	broad.mit.edu	37	16	12021657	12021657	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:12021657delT								GSPT1 (11138 upstream) : TNFRSF17 (37307 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	16	13552554	13552554	+	IGR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:13552554delA								SHISA9 (218282 upstream) : ERCC4 (461460 downstream)																																			---	---	---	---
PARN	5073	broad.mit.edu	37	16	14700252	14700252	+	Intron	DEL	G	-	-	rs62037478		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:14700252delG	uc010uzd.1	-						PARN_uc010uzc.1_Intron|PARN_uc010uze.1_Intron|PARN_uc010uzf.1_Intron|PARN_uc010uzg.1_Intron	NM_002582	NP_002573			poly(A)-specific ribonuclease (deadenylation						female gamete generation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|RNA modification	cytosol|nucleolus	metal ion binding|mRNA 3'-UTR binding|nucleotide binding|poly(A)-specific ribonuclease activity|protein binding			ovary(2)	2																		---	---	---	---
ABCC6P2	730013	broad.mit.edu	37	16	14916839	14916839	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:14916839delG	uc002dcu.2	-	2	156	c.123delC	c.(121-123)CCCfs	p.P41fs		NR_023387				SubName: Full=ATP-binding cassette, sub-family C (CFTR/MRP), member 6; SubName: Full=Up-regulated gene 7;												0																		---	---	---	---
RRN3	54700	broad.mit.edu	37	16	15164886	15164886	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:15164886delA	uc002dde.2	-						PDXDC1_uc002ddc.2_Intron|RRN3_uc010uzp.1_Intron|RRN3_uc010uzq.1_Intron	NM_018427	NP_060897			RRN3 RNA polymerase I transcription factor						regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm				ovary(1)	1																		---	---	---	---
SMG1	23049	broad.mit.edu	37	16	18857147	18857147	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:18857147delT	uc002dfm.2	-						SMG1_uc010bwb.2_Intron|SMG1_uc010bwa.2_Intron|SMG1_uc002dfo.3_Intron	NM_015092	NP_055907			PI-3-kinase-related kinase SMG-1						DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16																		---	---	---	---
SMG1	23049	broad.mit.edu	37	16	18895522	18895522	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:18895522delG	uc002dfm.2	-						SMG1_uc010bwb.2_Intron	NM_015092	NP_055907			PI-3-kinase-related kinase SMG-1						DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16																		---	---	---	---
TMC5	79838	broad.mit.edu	37	16	19455699	19455699	+	Intron	DEL	G	-	-	rs4782248	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:19455699delG	uc002dgc.3	+						TMC5_uc010vaq.1_Intron|TMC5_uc002dgb.3_Intron|TMC5_uc010var.1_Intron	NM_001105248	NP_001098718			transmembrane channel-like 5 isoform a							integral to membrane				skin(1)	1																		---	---	---	---
GPRC5B	51704	broad.mit.edu	37	16	19873331	19873331	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:19873331delA	uc002dgt.2	-						GPRC5B_uc010vav.1_Intron	NM_016235	NP_057319			G protein-coupled receptor, family C, group 5,											lung(1)|breast(1)|skin(1)	3																		---	---	---	---
Unknown	0	broad.mit.edu	37	16	21599051	21599052	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:21599051_21599052insT	uc002diq.3	+											Homo sapiens cDNA FLJ59829 complete cds.																														---	---	---	---
RRN3P1	730092	broad.mit.edu	37	16	21817398	21817399	+	Intron	INS	-	A	A	rs144931984	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:21817398_21817399insA	uc010vbl.1	-						uc002diq.3_Intron	NR_003370				SubName: Full=Putative uncharacterized protein ENSP00000219758;												0																		---	---	---	---
EARS2	124454	broad.mit.edu	37	16	23544150	23544150	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:23544150delT	uc002dlt.3	-						EARS2_uc002dlr.3_Intron|EARS2_uc002dls.3_Intron|EARS2_uc002dlu.2_Intron	NM_001083614	NP_001077083			glutamyl-tRNA synthetase 2 precursor						glutamyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|glutamate-tRNA ligase activity|RNA binding				0				GBM - Glioblastoma multiforme(48;0.0353)	L-Glutamic Acid(DB00142)													---	---	---	---
ERN2	10595	broad.mit.edu	37	16	23712222	23712223	+	Intron	DEL	CA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:23712222_23712223delCA	uc002dma.3	-						ERN2_uc010bxp.2_Intron|ERN2_uc010bxq.1_3'UTR	NM_033266	NP_150296			endoplasmic reticulum to nucleus signalling 2						apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)														---	---	---	---
RABEP2	79874	broad.mit.edu	37	16	28925916	28925916	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:28925916delG	uc002drq.2	-						uc010vct.1_Intron|RABEP2_uc010vdf.1_Intron|RABEP2_uc010byn.2_Intron|RABEP2_uc002drr.2_Intron	NM_024816	NP_079092			rabaptin, RAB GTPase binding effector protein 2						endocytosis|protein transport	early endosome	growth factor activity|GTPase activator activity			ovary(1)|breast(1)|skin(1)	3																		---	---	---	---
SEZ6L2	26470	broad.mit.edu	37	16	29910432	29910440	+	5'UTR	DEL	TTTTTTTTT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:29910432_29910440delTTTTTTTTT	uc002duq.3	-	1					uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_5'UTR|SEZ6L2_uc002dur.3_5'UTR|SEZ6L2_uc002dus.3_5'UTR|SEZ6L2_uc010vec.1_5'UTR|SEZ6L2_uc010ved.1_5'UTR|ASPHD1_uc002dut.2_5'Flank|ASPHD1_uc002duu.3_5'Flank|ASPHD1_uc010bzi.2_5'Flank	NM_201575	NP_963869			seizure related 6 homolog (mouse)-like 2 isoform							endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2																		---	---	---	---
FAM57B	83723	broad.mit.edu	37	16	30041821	30041821	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:30041821delC	uc002dvt.2	-	1	366	c.28delG	c.(28-30)GTGfs	p.V10fs	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|FAM57B_uc002dvu.2_5'Flank	NM_031478	NP_113666	Q71RH2	FA57B_HUMAN	hypothetical protein LOC83723	10						endoplasmic reticulum|integral to membrane					0																		---	---	---	---
RNF40	9810	broad.mit.edu	37	16	30779458	30779458	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:30779458delC	uc002dzq.2	+	13	1709	c.1586delC	c.(1585-1587)ACCfs	p.T529fs	RNF40_uc010caa.2_Frame_Shift_Del_p.T529fs|RNF40_uc010cab.2_Frame_Shift_Del_p.T429fs|RNF40_uc010vfa.1_Intron|RNF40_uc002dzr.2_Frame_Shift_Del_p.T529fs|RNF40_uc010vfb.1_Frame_Shift_Del_p.T221fs|RNF40_uc010vfc.1_5'Flank	NM_014771	NP_055586	O75150	BRE1B_HUMAN	ring finger protein 40	529					histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)	1			Colorectal(24;0.198)															---	---	---	---
ZNF629	23361	broad.mit.edu	37	16	30792971	30792971	+	3'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:30792971delT	uc002dzs.1	-	3						NM_001080417	NP_001073886			zinc finger protein 629						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			Colorectal(24;0.198)															---	---	---	---
FBXL19	54620	broad.mit.edu	37	16	30941646	30941646	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:30941646delG	uc002eab.2	+	7	1260	c.1102delG	c.(1102-1104)GGGfs	p.G368fs	FBXL19_uc002dzz.1_Frame_Shift_Del_p.G56fs|FBXL19_uc002eaa.1_Frame_Shift_Del_p.G267fs	NM_001099784	NP_001093254	Q6PCT2	FXL19_HUMAN	F-box and leucine-rich repeat protein 19	368							DNA binding|zinc ion binding			ovary(2)|lung(1)|breast(1)	4																		---	---	---	---
PRSS36	146547	broad.mit.edu	37	16	31151511	31151511	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:31151511delA	uc002ebd.2	-						PRSS36_uc010vff.1_Intron|PRSS36_uc010vfg.1_Intron|PRSS36_uc010vfh.1_Intron	NM_173502	NP_775773			protease, serine, 36 precursor						proteolysis	cytoplasm|proteinaceous extracellular matrix	serine-type endopeptidase activity			ovary(1)	1																		---	---	---	---
ZNF267	10308	broad.mit.edu	37	16	31896060	31896060	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:31896060delA	uc002ecs.3	+							NM_003414	NP_003405			zinc finger protein 267						multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)|skin(1)	4																		---	---	---	---
ZNF267	10308	broad.mit.edu	37	16	31896410	31896410	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:31896410delA	uc002ecs.3	+							NM_003414	NP_003405			zinc finger protein 267						multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)|skin(1)	4																		---	---	---	---
LOC283914	283914	broad.mit.edu	37	16	34624055	34624055	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:34624055delT	uc010vgc.1	+						LOC283914_uc002edw.2_Intron	NR_027080				Homo sapiens cDNA clone IMAGE:5271062.												0																		---	---	---	---
LONP2	83752	broad.mit.edu	37	16	48311580	48311580	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:48311580delT	uc002efi.1	+						LONP2_uc010vgm.1_Intron|LONP2_uc002efj.1_Intron	NM_031490	NP_113678			peroxisomal LON protease-like						misfolded or incompletely synthesized protein catabolic process|protein targeting to peroxisome|signal peptide processing	nucleoid|peroxisomal matrix	ATP binding|ATP-dependent peptidase activity|enzyme binding|sequence-specific DNA binding|serine-type endopeptidase activity				0																		---	---	---	---
HEATR3	55027	broad.mit.edu	37	16	50128484	50128484	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:50128484delT	uc002efw.2	+						HEATR3_uc002efx.2_Intron	NM_182922	NP_891552			HEAT repeat containing 3								binding			ovary(1)|skin(1)	2																		---	---	---	---
FTO	79068	broad.mit.edu	37	16	53967799	53967799	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:53967799delA	uc002ehr.2	+						FTO_uc010vha.1_Intron|FTO_uc010cbz.2_Intron|FTO_uc002ehs.2_5'Flank	NM_001080432	NP_001073901			fat mass and obesity associated						DNA dealkylation involved in DNA repair|oxidative single-stranded DNA demethylation|oxidative single-stranded RNA demethylation|RNA repair	nucleus	DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|oxidative DNA demethylase activity|oxidative RNA demethylase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0																		---	---	---	---
IRX3	79191	broad.mit.edu	37	16	54317567	54317567	+	3'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:54317567delT	uc002eht.1	-	4						NM_024336	NP_077312			iroquois homeobox 3						multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0																		---	---	---	---
MMP2	4313	broad.mit.edu	37	16	55527106	55527106	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:55527106delC	uc002ehz.3	+	9	1684	c.1373delC	c.(1372-1374)ACCfs	p.T458fs	MMP2_uc010vhd.1_Frame_Shift_Del_p.T382fs|MMP2_uc010ccc.2_Frame_Shift_Del_p.T408fs|MMP2_uc002eia.3_5'UTR	NM_004530	NP_004521	P08253	MMP2_HUMAN	matrix metalloproteinase 2 isoform a	458	Required for inhibitor TIMP2 binding.|Collagenase-like 2.				angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			large_intestine(3)|ovary(3)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	11		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)													---	---	---	---
CES1	1066	broad.mit.edu	37	16	55844240	55844240	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:55844240delT	uc002eim.2	-						CES1_uc010ccf.2_Intron|CES1_uc002eil.2_Intron|CES1_uc002ein.2_Intron	NM_001025194	NP_001020365			carboxylesterase 1 isoform b precursor						response to toxin	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0				all cancers(182;0.13)|Epithelial(162;0.137)	Aminoglutethimide(DB00357)|Bezafibrate(DB01393)|Cholestyramine(DB01432)|Moexipril(DB00691)													---	---	---	---
SLC12A3	6559	broad.mit.edu	37	16	56904753	56904753	+	Intron	DEL	T	-	-	rs71882529		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:56904753delT	uc010ccm.2	+						SLC12A3_uc002ekd.3_Intron|SLC12A3_uc010ccn.2_Intron	NM_001126108	NP_001119580			solute carrier family 12, member 3 isoform 3						sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			ovary(2)|breast(1)	3					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)													---	---	---	---
RSPRY1	89970	broad.mit.edu	37	16	57250733	57250733	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:57250733delC	uc002elb.2	+						RSPRY1_uc002elc.2_Intron|RSPRY1_uc002eld.2_Intron	NM_133368	NP_588609			ring finger and SPRY domain containing 1							extracellular region	zinc ion binding			ovary(1)	1																		---	---	---	---
CIAPIN1	57019	broad.mit.edu	37	16	57464912	57464913	+	Intron	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:57464912_57464913delTT	uc002ell.1	-						CIAPIN1_uc002elk.1_Intron|CIAPIN1_uc002elm.1_Intron|CIAPIN1_uc002eln.1_Intron|CIAPIN1_uc010cda.1_Intron|CIAPIN1_uc002elo.1_Intron	NM_020313	NP_064709			cytokine induced apoptosis inhibitor 1						anti-apoptosis|apoptosis	cytoplasm|nucleolus					0																		---	---	---	---
C16orf57	79650	broad.mit.edu	37	16	58054315	58054316	+	3'UTR	DEL	TC	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:58054315_58054316delTC	uc002emz.2	+	7					C16orf57_uc010vib.1_3'UTR	NM_024598	NP_078874			hypothetical protein LOC79650												0																OREG0023839	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
CDH16	1014	broad.mit.edu	37	16	66943698	66943699	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:66943698_66943699insA	uc002eql.2	-						CDH16_uc010cdy.2_Intron|CDH16_uc002eqm.2_Intron	NM_004062	NP_004053			cadherin 16 precursor						homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|upper_aerodigestive_tract(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)														---	---	---	---
CBFB	865	broad.mit.edu	37	16	67132464	67132464	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67132464delT	uc002era.2	+						CBFB_uc002erb.2_Intron|CBFB_uc010vja.1_Intron	NM_001755	NP_001746			core-binding factor, beta subunit isoform 2						transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)	2		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00189)|Epithelial(162;0.00755)|all cancers(182;0.066)				T	MYH11	AML								---	---	---	---
KCTD19	146212	broad.mit.edu	37	16	67325776	67325776	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67325776delA	uc002esu.2	-						KCTD19_uc002est.2_Intron|KCTD19_uc010vjj.1_Intron	NM_001100915	NP_001094385			potassium channel tetramerisation domain							voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)														---	---	---	---
KCTD19	146212	broad.mit.edu	37	16	67331704	67331704	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67331704delT	uc002esu.2	-						KCTD19_uc002est.2_Intron|KCTD19_uc010vjj.1_Intron	NM_001100915	NP_001094385			potassium channel tetramerisation domain							voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)														---	---	---	---
TMCO7	79613	broad.mit.edu	37	16	68911927	68911927	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:68911927delT	uc002ewi.3	+							NM_024562	NP_078838			transmembrane and coiled-coil domains 7							integral to membrane	binding				0		Ovarian(137;0.0568)		OV - Ovarian serous cystadenocarcinoma(108;0.0446)|Epithelial(162;0.198)														---	---	---	---
TMCO7	79613	broad.mit.edu	37	16	69059840	69059840	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:69059840delA	uc002ewi.3	+							NM_024562	NP_078838			transmembrane and coiled-coil domains 7							integral to membrane	binding				0		Ovarian(137;0.0568)		OV - Ovarian serous cystadenocarcinoma(108;0.0446)|Epithelial(162;0.198)														---	---	---	---
CIRH1A	84916	broad.mit.edu	37	16	69197164	69197164	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:69197164delT	uc002ews.3	+						CIRH1A_uc002ewr.2_Intron|CIRH1A_uc002ewt.3_Intron|CIRH1A_uc010cfi.2_Intron	NM_032830	NP_116219			cirhin							nucleolus	protein binding				0				OV - Ovarian serous cystadenocarcinoma(108;0.125)														---	---	---	---
NOB1	28987	broad.mit.edu	37	16	69783588	69783588	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:69783588delT	uc002exs.2	-							NM_014062	NP_054781			nin one binding protein							nucleus	metal ion binding|protein binding				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	16	70260603	70260603	+	5'Flank	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:70260603delT	uc002eyl.1	-											Homo sapiens cDNA FLJ46379 fis, clone THYMU2003803, moderately similar to Homo sapiens PI-3-kinase-related kinase SMG-1 (SMG1).																														---	---	---	---
IL34	146433	broad.mit.edu	37	16	70690422	70690422	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:70690422delA	uc002ezh.1	+						IL34_uc002ezi.1_Intron	NM_152456	NP_689669			interleukin 34 precursor						positive regulation of cell proliferation|positive regulation of protein phosphorylation	extracellular space	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding			central_nervous_system(1)|skin(1)	2																		---	---	---	---
MTSS1L	92154	broad.mit.edu	37	16	70714812	70714813	+	Intron	DEL	GG	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:70714812_70714813delGG	uc002ezj.2	-						MTSS1L_uc002ezk.1_5'Flank	NM_138383	NP_612392			metastasis suppressor 1-like						filopodium assembly|signal transduction		actin binding|cytoskeletal adaptor activity|SH3 domain binding			central_nervous_system(1)	1																		---	---	---	---
HYDIN	54768	broad.mit.edu	37	16	70935161	70935161	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:70935161delT	uc002ezr.2	-							NM_032821	NP_116210			hydrocephalus inducing isoform a											ovary(1)|skin(1)	2		Ovarian(137;0.0654)																---	---	---	---
TAT	6898	broad.mit.edu	37	16	71607537	71607537	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:71607537delT	uc002fap.2	-							NM_000353	NP_000344			tyrosine aminotransferase						2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-tyrosine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			ovary(2)	2		Ovarian(137;0.125)		Kidney(780;0.0157)	L-Glutamic Acid(DB00142)|L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Pyridoxal Phosphate(DB00114)													---	---	---	---
MARVELD3	91862	broad.mit.edu	37	16	71668085	71668085	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:71668085delT	uc002fat.2	+						MARVELD3_uc002fau.2_Intron|MARVELD3_uc010cge.2_Intron	NM_052858	NP_443090			MARVEL domain containing 3 isoform 2							integral to membrane				skin(1)	1		Ovarian(137;0.125)																---	---	---	---
AP1G1	164	broad.mit.edu	37	16	71803440	71803440	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:71803440delA	uc010cgg.2	-						AP1G1_uc002fba.2_Intron|AP1G1_uc002fbb.2_Intron|AP1G1_uc010vmg.1_Intron|AP1G1_uc010vmh.1_Intron	NM_001128	NP_001119			adaptor-related protein complex 1, gamma 1						endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity			ovary(2)	2		Ovarian(137;0.125)																---	---	---	---
CNTNAP4	85445	broad.mit.edu	37	16	76513582	76513582	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:76513582delA	uc002feu.1	+						CNTNAP4_uc002fev.1_Intron|CNTNAP4_uc010chb.1_Intron|CNTNAP4_uc002fex.1_Intron|CNTNAP4_uc002few.2_Intron	NM_033401	NP_207837			cell recognition protein CASPR4 isoform 1						cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2																		---	---	---	---
CENPN	55839	broad.mit.edu	37	16	81051343	81051343	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:81051343delT	uc002ffx.2	+						CENPN_uc002ffw.3_Intron|CENPN_uc010vnl.1_Intron|CENPN_uc010vnm.1_Intron|CENPN_uc002ffy.3_Intron	NM_001100624	NP_001094094			centromere protein N isoform 2						CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm					0																		---	---	---	---
PKD1L2	114780	broad.mit.edu	37	16	81134589	81134589	+	3'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:81134589delT	uc002fgh.1	-	45					PKD1L2_uc002fgf.1_3'UTR|PKD1L2_uc002fgg.1_RNA	NM_052892	NP_443124			polycystin 1-like 2 isoform a						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3																		---	---	---	---
SLC38A8	146167	broad.mit.edu	37	16	84066667	84066668	+	Intron	DEL	TC	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:84066667_84066668delTC	uc002fhg.1	-							NM_001080442	NP_001073911			solute carrier family 38, member 8						amino acid transport|sodium ion transport	integral to membrane					0																		---	---	---	---
MBTPS1	8720	broad.mit.edu	37	16	84094451	84094452	+	Intron	DEL	TT	-	-	rs71920773		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:84094451_84094452delTT	uc002fhi.2	-						MBTPS1_uc002fhh.2_Intron	NM_003791	NP_003782			membrane-bound transcription factor site-1						cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			ovary(2)	2																		---	---	---	---
KCNG4	93107	broad.mit.edu	37	16	84270891	84270892	+	Frame_Shift_Ins	INS	-	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:84270891_84270892insC	uc010voc.1	-	2	321_322	c.200_201insG	c.(199-201)GGCfs	p.G67fs	KCNG4_uc002fhu.1_Frame_Shift_Ins_p.G67fs	NM_172347	NP_758857	Q8TDN1	KCNG4_HUMAN	potassium voltage-gated channel, subfamily G,	67	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)	3																		---	---	---	---
ZCCHC14	23174	broad.mit.edu	37	16	87445883	87445883	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:87445883delG	uc002fjz.1	-	12	2060	c.2033delC	c.(2032-2034)ACAfs	p.T678fs	ZCCHC14_uc002fka.1_RNA|ZCCHC14_uc002fkb.2_Frame_Shift_Del_p.T454fs	NM_015144	NP_055959	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	678					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			upper_aerodigestive_tract(1)|breast(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0285)														---	---	---	---
ZC3H18	124245	broad.mit.edu	37	16	88691141	88691141	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:88691141delC	uc002fky.2	+	12	2230	c.2030delC	c.(2029-2031)ACCfs	p.T677fs	ZC3H18_uc010voz.1_Frame_Shift_Del_p.T701fs|ZC3H18_uc010chw.2_RNA|ZC3H18_uc002fkz.2_5'Flank	NM_144604	NP_653205	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	677	Ser-rich.					nucleus	nucleic acid binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0542)														---	---	---	---
CTU2	348180	broad.mit.edu	37	16	88779686	88779687	+	Intron	INS	-	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:88779686_88779687insC	uc002flm.2	+						CTU2_uc002fln.2_Intron|CTU2_uc010chz.2_Intron|CTU2_uc010cia.2_Intron	NM_001012759	NP_001012777			cytoplasmic tRNA 2-thiolation protein 2 isoform						tRNA thio-modification|tRNA wobble uridine modification	cytoplasm|protein complex|soluble fraction	protein binding			skin(1)	1																		---	---	---	---
PITPNA	5306	broad.mit.edu	37	17	1451693	1451693	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:1451693delA	uc002fst.3	-						PITPNA_uc010cjt.2_Intron|PITPNA_uc010cju.2_Intron|PITPNA_uc010vqn.1_Intron	NM_006224	NP_006215			phosphatidylinositol transfer protein, alpha						axon guidance|lipid metabolic process|visual perception	cytoplasm	phosphatidylcholine transmembrane transporter activity|phosphatidylinositol transporter activity|protein binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0845)														---	---	---	---
PAFAH1B1	5048	broad.mit.edu	37	17	2568632	2568632	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:2568632delT	uc002fuw.3	+						PAFAH1B1_uc010ckb.1_Intron	NM_000430	NP_000421			platelet-activating factor acetylhydrolase,						acrosome assembly|actin cytoskeleton organization|adult locomotory behavior|brain morphogenesis|corpus callosum morphogenesis|establishment of mitotic spindle orientation|G2/M transition of mitotic cell cycle|hippocampus development|layer formation in cerebral cortex|learning or memory|lipid catabolic process|microtubule organizing center organization|mitotic prometaphase|neuroblast proliferation|neuromuscular process controlling balance|neuron migration|platelet activating factor metabolic process|regulation of Rho GTPase activity|retrograde axon cargo transport|synaptic transmission|vesicle transport along microtubule	astral microtubule|cell cortex|centrosome|cytosol|kinetochore|motile primary cilium|nuclear membrane|perinuclear region of cytoplasm	dynactin binding|heparin binding|microtubule binding|phospholipase binding|phosphoprotein binding|protein homodimerization activity			skin(1)	1																		---	---	---	---
KIAA0664	23277	broad.mit.edu	37	17	2597582	2597582	+	Intron	DEL	C	-	-	rs115326538	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:2597582delC	uc002fuy.1	-						KIAA0664_uc002fux.1_Intron|KIAA0664_uc010ckc.1_Intron	NM_015229	NP_056044			hypothetical protein LOC23277								binding			breast(2)	2																		---	---	---	---
ITGAE	3682	broad.mit.edu	37	17	3623753	3623754	+	Intron	DEL	TG	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:3623753_3623754delTG	uc002fwo.3	-						ITGAE_uc002fwn.3_Intron	NM_002208	NP_002199			integrin, alpha E precursor						cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			large_intestine(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)														---	---	---	---
ITGAE	3682	broad.mit.edu	37	17	3704547	3704548	+	5'Flank	DEL	CA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:3704547_3704548delCA	uc002fwo.3	-							NM_002208	NP_002199			integrin, alpha E precursor						cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			large_intestine(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)														---	---	---	---
DLG4	1742	broad.mit.edu	37	17	7094784	7094784	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7094784delA	uc002get.3	-						DLG4_uc010vtm.1_Intron|DLG4_uc010vtn.1_Intron|DLG4_uc010cly.2_Intron|DLG4_uc010vto.1_Intron	NM_001365	NP_001356			post-synaptic density protein 95 isoform 1						axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding			ovary(1)|breast(1)	2																		---	---	---	---
DULLARD	23399	broad.mit.edu	37	17	7150790	7150792	+	Intron	DEL	TTT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7150790_7150792delTTT	uc002gfd.2	-						DULLARD_uc002gfe.2_Intron|DULLARD_uc002gff.2_Intron|DULLARD_uc002gfc.2_Intron	NM_001143775	NP_001137247			dullard homolog						nuclear envelope organization|protein dephosphorylation	endoplasmic reticulum membrane|integral to membrane|nuclear membrane	protein serine/threonine phosphatase activity				0																		---	---	---	---
SPEM1	374768	broad.mit.edu	37	17	7323934	7323935	+	Intron	INS	-	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7323934_7323935insC	uc002ggv.2	+						FGF11_uc010vtw.1_Intron	NM_199339	NP_955371			spermatid maturation 1						cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|integral to membrane					0		Prostate(122;0.173)																---	---	---	---
POLR2A	5430	broad.mit.edu	37	17	7415710	7415710	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7415710delG	uc002ghf.3	+							NM_000937	NP_000928			DNA-directed RNA polymerase II A						mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			pancreas(1)	1		Prostate(122;0.173)																---	---	---	---
WRAP53	55135	broad.mit.edu	37	17	7603866	7603867	+	Intron	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7603866_7603867delAA	uc010vuh.1	+						WRAP53_uc010vui.1_Intron|WRAP53_uc002gip.2_Intron|WRAP53_uc002gir.2_Intron|WRAP53_uc002giq.2_Intron|WRAP53_uc010cnl.2_Intron|WRAP53_uc010vuj.1_5'Flank	NM_001143990	NP_001137462			WD repeat domain 79 isoform 2						positive regulation of telomerase activity|telomere formation via telomerase	Cajal body|cytoplasm|telomerase holoenzyme complex	protein binding|RNA binding				0																		---	---	---	---
TMEM107	84314	broad.mit.edu	37	17	8079373	8079373	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:8079373delA	uc002gkg.3	-						TMEM107_uc002gkh.3_Intron|TMEM107_uc002gki.3_Intron|TMEM107_uc002gkj.3_Intron|TMEM107_uc002gkk.2_Intron	NM_183065	NP_898888			transmembrane protein 107 isoform 2							integral to membrane					0																		---	---	---	---
STX8	9482	broad.mit.edu	37	17	9282137	9282137	+	Intron	DEL	A	-	-	rs139246965	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:9282137delA	uc002glx.2	-							NM_004853	NP_004844			syntaxin 8						transport	endoplasmic reticulum|integral to plasma membrane				central_nervous_system(1)	1																		---	---	---	---
MYH13	8735	broad.mit.edu	37	17	10216089	10216089	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:10216089delT	uc002gmk.1	-							NM_003802	NP_003793			myosin, heavy polypeptide 13, skeletal muscle						muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6																		---	---	---	---
Unknown	0	broad.mit.edu	37	17	14608345	14608345	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:14608345delT								HS3ST3B1 (358853 upstream) : PMP22 (524752 downstream)																																			---	---	---	---
NCOR1	9611	broad.mit.edu	37	17	15943963	15943963	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:15943963delT	uc002gpo.2	-						NCOR1_uc002gpn.2_Intron|NCOR1_uc002gpl.2_Intron|NCOR1_uc002gpm.2_Intron|NCOR1_uc010vwb.1_Intron|NCOR1_uc010coy.2_Intron	NM_006311	NP_006302			nuclear receptor co-repressor 1						cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)														---	---	---	---
NCOR1	9611	broad.mit.edu	37	17	15984055	15984055	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:15984055delA	uc002gpo.2	-						NCOR1_uc002gpn.2_Intron|NCOR1_uc002gpp.1_Intron|NCOR1_uc010vwb.1_5'Flank|NCOR1_uc010coy.2_5'Flank|NCOR1_uc010vwc.1_5'Flank	NM_006311	NP_006302			nuclear receptor co-repressor 1						cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)														---	---	---	---
NCOR1	9611	broad.mit.edu	37	17	16011664	16011664	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:16011664delT	uc002gpo.2	-						NCOR1_uc002gpn.2_Intron|NCOR1_uc002gpp.1_Intron|NCOR1_uc002gpr.2_Intron	NM_006311	NP_006302			nuclear receptor co-repressor 1						cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)														---	---	---	---
SREBF1	6720	broad.mit.edu	37	17	17720837	17720838	+	Intron	INS	-	G	G	rs2282180	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:17720837_17720838insG	uc002gru.1	-						SREBF1_uc002grp.1_Intron|SREBF1_uc002grq.1_Intron|SREBF1_uc002grr.1_Intron|SREBF1_uc002grs.1_Intron|SREBF1_uc002grt.1_Intron	NM_004176	NP_004167			sterol regulatory element binding transcription						cellular response to starvation|cholesterol metabolic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleus	protein binding|protein binding|sequence-specific DNA binding transcription factor activity|sterol response element binding			skin(1)	1																		---	---	---	---
CCDC144B	284047	broad.mit.edu	37	17	18498498	18498498	+	Intron	DEL	A	-	-	rs71844421		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:18498498delA	uc002gub.1	-						CCDC144B_uc002gua.3_Intron|CCDC144B_uc010vyc.1_Intron	NM_182568	NP_872374			coiled-coil domain containing 144B											ovary(1)|skin(1)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	17	18988562	18988562	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:18988562delT								GRAP (38226 upstream) : GRAPL (42220 downstream)																																			---	---	---	---
CYTSB	92521	broad.mit.edu	37	17	20108263	20108263	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:20108263delA	uc002gwq.2	+	4	1046	c.901delA	c.(901-903)AAAfs	p.K301fs	CYTSB_uc010cqx.2_Frame_Shift_Del_p.K301fs|CYTSB_uc002gwr.2_Frame_Shift_Del_p.K301fs|CYTSB_uc002gws.2_Frame_Shift_Del_p.K301fs|CYTSB_uc002gwv.2_Frame_Shift_Del_p.K220fs|CYTSB_uc010vzf.1_Intron|CYTSB_uc002gww.2_Frame_Shift_Del_p.K77fs|CYTSB_uc002gwt.2_Frame_Shift_Del_p.K220fs|CYTSB_uc002gwu.2_Frame_Shift_Del_p.K220fs	NM_001033553	NP_001028725	Q5M775	CYTSB_HUMAN	spectrin domain with coiled-coils 1 NSP5b3b	301	Ser-rich.					nucleus					0																		---	---	---	---
CYTSB	92521	broad.mit.edu	37	17	20209172	20209172	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:20209172delT	uc002gwq.2	+						CYTSB_uc002gws.2_Intron|CYTSB_uc002gwv.2_Intron|CYTSB_uc010vzf.1_Intron|CYTSB_uc002gww.2_Intron	NM_001033553	NP_001028725			spectrin domain with coiled-coils 1 NSP5b3b							nucleus					0																		---	---	---	---
KSR1	8844	broad.mit.edu	37	17	25853478	25853478	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:25853478delT	uc010crg.2	+						KSR1_uc002gzj.1_Intron	NM_014238	NP_055053			kinase suppressor of ras						Ras protein signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|central_nervous_system(1)	4	Lung NSC(42;0.00836)		BRCA - Breast invasive adenocarcinoma(3;0.00122)	UCEC - Uterine corpus endometrioid carcinoma (53;0.168)														---	---	---	---
NLK	51701	broad.mit.edu	37	17	26459626	26459627	+	Intron	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:26459626_26459627delTT	uc010crj.2	+						NLK_uc010cri.1_Intron	NM_016231	NP_057315			nemo like kinase						intracellular protein kinase cascade|negative regulation of Wnt receptor signaling pathway|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|serine phosphorylation of STAT3 protein|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|nucleus	ATP binding|magnesium ion binding|MAP kinase activity|SH2 domain binding|transcription factor binding|ubiquitin protein ligase binding			ovary(1)|lung(1)|central_nervous_system(1)	3	all_lung(13;0.000343)|Lung NSC(42;0.00184)			UCEC - Uterine corpus endometrioid carcinoma (53;0.168)														---	---	---	---
NLK	51701	broad.mit.edu	37	17	26512302	26512302	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:26512302delT	uc010crj.2	+						NLK_uc010cri.1_Intron	NM_016231	NP_057315			nemo like kinase						intracellular protein kinase cascade|negative regulation of Wnt receptor signaling pathway|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|serine phosphorylation of STAT3 protein|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|nucleus	ATP binding|magnesium ion binding|MAP kinase activity|SH2 domain binding|transcription factor binding|ubiquitin protein ligase binding			ovary(1)|lung(1)|central_nervous_system(1)	3	all_lung(13;0.000343)|Lung NSC(42;0.00184)			UCEC - Uterine corpus endometrioid carcinoma (53;0.168)														---	---	---	---
KIAA0100	9703	broad.mit.edu	37	17	26946487	26946488	+	Intron	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:26946487_26946488delAA	uc002hbu.2	-						KIAA0100_uc002hbt.2_Intron	NM_014680	NP_055495			hypothetical protein LOC9703 precursor							extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)																	---	---	---	---
KIAA0100	9703	broad.mit.edu	37	17	26947118	26947118	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:26947118delG	uc002hbu.2	-						KIAA0100_uc002hbt.2_Intron	NM_014680	NP_055495			hypothetical protein LOC9703 precursor							extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)																	---	---	---	---
CRYBA1	1411	broad.mit.edu	37	17	27580574	27580575	+	Intron	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:27580574_27580575delAA	uc002hdw.2	+							NM_005208	NP_005199			crystallin, beta A3						visual perception	soluble fraction	structural constituent of eye lens				0			BRCA - Breast invasive adenocarcinoma(11;3.3e-05)|Colorectal(6;0.0178)|COAD - Colon adenocarcinoma(6;0.0551)															---	---	---	---
EFCAB5	374786	broad.mit.edu	37	17	28396072	28396072	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:28396072delA	uc002het.2	+						EFCAB5_uc010wbj.1_Intron|EFCAB5_uc010wbk.1_Intron|EFCAB5_uc010csd.2_Intron|EFCAB5_uc010cse.2_Intron|EFCAB5_uc010csf.2_Intron	NM_198529	NP_940931			EF-hand calcium binding domain 5 isoform a								calcium ion binding			ovary(1)|skin(1)	2																		---	---	---	---
TBC1D29	26083	broad.mit.edu	37	17	28885004	28885005	+	5'Flank	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:28885004_28885005insA	uc002hfh.2	+						uc002hfg.1_5'Flank|TBC1D29_uc002hfi.2_5'Flank	NM_015594	NP_056409			TBC1 domain family, member 29							intracellular	Rab GTPase activator activity				0		Myeloproliferative disorder(56;0.0255)																---	---	---	---
CRLF3	51379	broad.mit.edu	37	17	29112800	29112800	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:29112800delA	uc002hfr.3	-						CRLF3_uc010wbr.1_Intron	NM_015986	NP_057070			cytokine receptor-like factor 3						negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|positive regulation of cell cycle arrest|positive regulation of JAK-STAT cascade|positive regulation of transcription from RNA polymerase II promoter	cytoplasm					0		all_hematologic(16;0.014)|Acute lymphoblastic leukemia(14;0.0236)|Myeloproliferative disorder(56;0.0255)																---	---	---	---
ATAD5	79915	broad.mit.edu	37	17	29157882	29157882	+	5'Flank	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:29157882delA	uc002hfs.1	+							NM_024857	NP_079133			ATPase family, AAA domain containing 5						response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)																---	---	---	---
LRRC37B	114659	broad.mit.edu	37	17	30362358	30362358	+	Intron	DEL	A	-	-	rs76777694		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:30362358delA	uc002hgu.2	+						LRRC37B_uc010wbx.1_Intron|LRRC37B_uc010csu.2_Intron	NM_052888	NP_443120			leucine rich repeat containing 37B precursor							integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)																---	---	---	---
RHOT1	55288	broad.mit.edu	37	17	30500730	30500730	+	Intron	DEL	A	-	-	rs79743579		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:30500730delA	uc002hgz.2	+						RHOT1_uc002hgw.2_Intron|RHOT1_uc002hgy.2_Intron|RHOT1_uc002hha.2_Intron|RHOT1_uc010csv.2_Intron|RHOT1_uc002hgx.2_Intron|RHOT1_uc010wby.1_Intron|RHOT1_uc002hhb.2_Intron|RHOT1_uc002hgv.2_Intron	NM_018307	NP_060777			ras homolog gene family, member T1 isoform 3						apoptosis|cellular homeostasis|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to mitochondrial outer membrane|plasma membrane	calcium ion binding|GTP binding|GTPase activity|protein binding			ovary(3)|central_nervous_system(1)	4		Myeloproliferative disorder(56;0.0255)|Breast(31;0.116)|Ovarian(249;0.182)																---	---	---	---
RHBDL3	162494	broad.mit.edu	37	17	30648240	30648240	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:30648240delC	uc002hhe.1	+	9	1221	c.1207delC	c.(1207-1209)CCCfs	p.P403fs	RHBDL3_uc010csw.1_Frame_Shift_Del_p.P395fs|RHBDL3_uc010csx.1_Frame_Shift_Del_p.S369fs|RHBDL3_uc010csy.1_Frame_Shift_Del_p.P305fs|RHBDL3_uc002hhf.1_Frame_Shift_Del_p.P305fs	NM_138328	NP_612201	P58872	RHBL3_HUMAN	rhomboid protease 3	403					proteolysis	integral to membrane	calcium ion binding|serine-type endopeptidase activity			ovary(1)	1		Breast(31;0.116)|Ovarian(249;0.182)																---	---	---	---
PSMD11	5717	broad.mit.edu	37	17	30773801	30773801	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:30773801delT	uc010cta.1	+						PSMD11_uc010wbz.1_Intron|PSMD11_uc002hhm.2_Intron	NM_002815	NP_002806			proteasome 26S non-ATPase subunit 11						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding			ovary(1)	1		Breast(31;0.159)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.109)															---	---	---	---
NLE1	54475	broad.mit.edu	37	17	33466212	33466212	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:33466212delA	uc002hiy.1	-						NLE1_uc010ctn.1_Intron|NLE1_uc002hiz.1_Intron	NM_018096	NP_060566			Notchless gene homolog isoform a							nucleolus				breast(3)|ovary(1)	4		Ovarian(249;0.17)																---	---	---	---
UNC45B	146862	broad.mit.edu	37	17	33501478	33501478	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:33501478delG	uc002hja.2	+						UNC45B_uc002hjb.2_Intron|UNC45B_uc002hjc.2_Intron|UNC45B_uc010cto.2_Intron	NM_173167	NP_775259			cardiomyopathy associated 4 isoform 1						cell differentiation|muscle organ development	cytosol	binding			ovary(3)|central_nervous_system(2)|breast(1)	6		Ovarian(249;0.17)																---	---	---	---
AP2B1	163	broad.mit.edu	37	17	34036426	34036426	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:34036426delA	uc002hjr.2	+						AP2B1_uc002hjq.2_Intron|AP2B1_uc010wci.1_Intron|AP2B1_uc002hjs.2_Intron|AP2B1_uc002hjt.2_Intron|AP2B1_uc010ctv.2_Intron|AP2B1_uc010wcj.1_Intron	NM_001282	NP_001273			adaptor-related protein complex 2, beta 1						axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|coated pit|cytosol|endocytic vesicle membrane|plasma membrane	clathrin binding|protein transporter activity			ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)														---	---	---	---
CCL23	6368	broad.mit.edu	37	17	34340465	34340465	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:34340465delT	uc002hkt.1	-						CCL23_uc002hks.1_Intron	NM_145898	NP_665905			small inducible cytokine A23 isoform CKbeta8						cell-cell signaling|cellular calcium ion homeostasis|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response|negative regulation of cell proliferation	extracellular space	chemokine activity|heparin binding				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)	Treprostinil(DB00374)													---	---	---	---
GGNBP2	79893	broad.mit.edu	37	17	34942126	34942126	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:34942126delA	uc002hnb.2	+						GGNBP2_uc002hna.2_3'UTR|GGNBP2_uc002hnc.1_Intron	NM_024835	NP_079111			zinc finger protein 403						cell differentiation|multicellular organismal development|spermatogenesis	cytoplasmic membrane-bounded vesicle				ovary(2)	2		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)														---	---	---	---
LHX1	3975	broad.mit.edu	37	17	35300395	35300395	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:35300395delC	uc002hnh.1	+	5	2184	c.1188delC	c.(1186-1188)CACfs	p.H396fs		NM_005568	NP_005559	P48742	LHX1_HUMAN	LIM homeobox protein 1	396					cerebellar Purkinje cell differentiation|cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation|cervix development|comma-shaped body morphogenesis|dorsal/ventral pattern formation|ectoderm formation|embryonic pattern specification|embryonic retina morphogenesis in camera-type eye|embryonic viscerocranium morphogenesis|endoderm formation|forebrain regionalization|head development|motor axon guidance|negative regulation of transcription, DNA-dependent|nephric duct morphogenesis|nephron tubule epithelial cell differentiation|neuron migration|oviduct epithelium development|paramesonephric duct development|positive regulation of anterior head development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of transcription, DNA-dependent|post-embryonic development|primitive streak formation|renal vesicle morphogenesis|retina layer formation|S-shaped body morphogenesis|spinal cord association neuron differentiation|transcription from RNA polymerase II promoter|ureteric bud development|uterine epithelium development|vagina development	nucleus|protein complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(25;0.00607)																---	---	---	---
TADA2A	6871	broad.mit.edu	37	17	35787142	35787142	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:35787142delT	uc002hnt.2	+						TADA2A_uc002hnu.1_Intron|TADA2A_uc002hnv.2_Intron|TADA2A_uc010wdd.1_Intron|TADA2A_uc002hnw.2_Intron	NM_001488	NP_001479			transcriptional adaptor 2A isoform a						histone H3 acetylation|transcription from RNA polymerase II promoter	chromosome|PCAF complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|zinc ion binding			breast(3)|skin(1)	4																		---	---	---	---
CDK12	51755	broad.mit.edu	37	17	37682639	37682639	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:37682639delT	uc010cvv.2	+						CDK12_uc002hrw.3_Intron	NM_016507	NP_057591			Cdc2-related kinase, arginine/serine-rich						mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			ovary(10)|lung(4)|breast(2)|skin(2)|large_intestine(1)	19															TCGA Ovarian(9;0.13)			---	---	---	---
ERBB2	2064	broad.mit.edu	37	17	37864524	37864524	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:37864524delG	uc002hso.2	+						ERBB2_uc002hsm.2_Intron|ERBB2_uc010cwa.2_Intron|ERBB2_uc002hsp.2_Intron|ERBB2_uc010cwb.2_Intron|ERBB2_uc010wek.1_Intron|ERBB2_uc002hsl.2_Intron|ERBB2_uc002hsn.1_Intron	NM_004448	NP_004439			erbB-2 isoform a						cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			---	---	---	---
CASC3	22794	broad.mit.edu	37	17	38319330	38319330	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:38319330delA	uc010cwt.1	+						CASC3_uc010cws.1_Intron|CASC3_uc002hue.2_Intron	NM_007359	NP_031385			metastatic lymph node 51						mRNA processing|mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translation|response to stress|RNA splicing	exon-exon junction complex|nuclear speck|perinuclear region of cytoplasm	identical protein binding|RNA binding|ubiquitin protein ligase binding			ovary(1)	1																		---	---	---	---
TOP2A	7153	broad.mit.edu	37	17	38546381	38546381	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:38546381delT	uc002huq.2	-	34	4429	c.4303delA	c.(4303-4305)AGGfs	p.R1435fs		NM_001067	NP_001058	P11388	TOP2A_HUMAN	DNA topoisomerase II, alpha isozyme	1435					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)													---	---	---	---
TOP2A	7153	broad.mit.edu	37	17	38562532	38562532	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:38562532delT	uc002huq.2	-							NM_001067	NP_001058			DNA topoisomerase II, alpha isozyme						apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)													---	---	---	---
TTC25	83538	broad.mit.edu	37	17	40104749	40104749	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40104749delT	uc002hyj.3	+						TTC25_uc010cxt.2_Intron	NM_031421	NP_113609			tetratricopeptide repeat domain 25							cytoplasm	protein binding			ovary(1)	1		all_cancers(22;8.16e-06)|Breast(137;0.000143)|all_epithelial(22;0.000236)																---	---	---	---
NKIRAS2	28511	broad.mit.edu	37	17	40174474	40174474	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40174474delG	uc002hyq.2	+	3	217	c.152delG	c.(151-153)CGGfs	p.R51fs	NKIRAS2_uc010wgd.1_Frame_Shift_Del_p.R51fs|NKIRAS2_uc002hyr.2_Frame_Shift_Del_p.R51fs|NKIRAS2_uc002hys.2_Frame_Shift_Del_p.R51fs|NKIRAS2_uc010wge.1_Frame_Shift_Del_p.R51fs|NKIRAS2_uc002hyt.2_Frame_Shift_Del_p.R51fs	NM_001001349	NP_001001349	Q9NYR9	KBRS2_HUMAN	NFKB inhibitor interacting Ras-like 2 isoform a	51	Small GTPase-like.				I-kappaB kinase/NF-kappaB cascade|small GTPase mediated signal transduction	cytoplasm	GTP binding|GTPase activity			ovary(1)	1		all_cancers(22;1.1e-05)|Breast(137;0.000143)|all_epithelial(22;0.000319)																---	---	---	---
AARSD1	80755	broad.mit.edu	37	17	41102792	41102792	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:41102792delA	uc002icc.2	-						AARSD1_uc002icd.2_Intron|AARSD1_uc002ice.2_Intron|AARSD1_uc002icf.2_Intron|AARSD1_uc010whg.1_Intron	NM_025267	NP_079543			alanyl-tRNA synthetase domain containing 1						alanyl-tRNA aminoacylation	cytoplasm	alanine-tRNA ligase activity|ATP binding|metal ion binding|nucleic acid binding				0		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.161)														---	---	---	---
RPL27	6155	broad.mit.edu	37	17	41154524	41154524	+	Intron	DEL	A	-	-	rs76067241		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:41154524delA	uc002icj.2	+						RPL27_uc002ick.2_Intron	NM_000988	NP_000979			ribosomal protein L27						endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	structural constituent of ribosome				0		Breast(137;0.000717)|Ovarian(249;0.0776)		BRCA - Breast invasive adenocarcinoma(366;0.157)														---	---	---	---
TMEM106A	113277	broad.mit.edu	37	17	41370074	41370074	+	3'UTR	DEL	T	-	-	rs34981932	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:41370074delT	uc002idn.1	+	9					TMEM106A_uc010why.1_3'UTR|TMEM106A_uc010cze.1_3'UTR|TMEM106A_uc010whz.1_3'UTR	NM_145041	NP_659478			transmembrane protein 106A							integral to membrane					0		Breast(137;0.0164)		BRCA - Breast invasive adenocarcinoma(366;0.0917)														---	---	---	---
ETV4	2118	broad.mit.edu	37	17	41606334	41606334	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:41606334delT	uc002idw.2	-						ETV4_uc002idv.2_Intron|ETV4_uc010wih.1_Intron|ETV4_uc010czh.2_Intron|ETV4_uc010wii.1_Intron|ETV4_uc002idx.2_Intron|ETV4_uc010wij.1_Intron	NM_001986	NP_001977			ets variant gene 4 (E1A enhancer binding						positive regulation of transcription, DNA-dependent	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/ETV4(6)	bone(4)|soft_tissue(2)|ovary(1)	7		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.0798)				T	EWSR1|TMPRSS2|DDX5|KLK2|CANT1	Ewing sarcoma|Prostate carcinoma								---	---	---	---
G6PC3	92579	broad.mit.edu	37	17	42151308	42151308	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:42151308delA	uc002iex.2	+						G6PC3_uc002iey.2_Intron|G6PC3_uc010czo.2_Intron|G6PC3_uc002iez.2_Intron|G6PC3_uc002ifb.2_5'Flank|G6PC3_uc002ifc.2_5'Flank	NM_138387	NP_612396			glucose-6-phosphatase catalytic subunit 3						gluconeogenesis|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphatase activity			skin(1)	1		Breast(137;0.00637)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.113)														---	---	---	---
FAM171A2	284069	broad.mit.edu	37	17	42443067	42443068	+	5'Flank	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:42443067_42443068insT	uc002igs.2	-							NM_198475	NP_940877			family with sequence similarity 171, member A2							integral to membrane					0																		---	---	---	---
EFTUD2	9343	broad.mit.edu	37	17	42963797	42963797	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:42963797delA	uc002ihn.2	-						EFTUD2_uc010wje.1_Intron|EFTUD2_uc010wjf.1_Intron	NM_004247	NP_004238			elongation factor Tu GTP binding domain							Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			ovary(1)	1		Prostate(33;0.109)																---	---	---	---
CDC27	996	broad.mit.edu	37	17	45236511	45236511	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:45236511delT	uc002ild.3	-						CDC27_uc002ile.3_Intron|CDC27_uc002ilf.3_Intron|CDC27_uc010wkp.1_Intron|CDC27_uc010wkq.1_Intron	NM_001256	NP_001247			cell division cycle protein 27 isoform 2						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			lung(2)|breast(2)|ovary(1)	5																		---	---	---	---
C17orf57	124989	broad.mit.edu	37	17	45455421	45455422	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:45455421_45455422insA	uc002iln.2	+						C17orf57_uc002ilm.2_Intron|C17orf57_uc010daz.1_Intron	NM_152347	NP_689560			hypothetical protein LOC124989								calcium ion binding			breast(1)|central_nervous_system(1)|skin(1)	3																		---	---	---	---
C17orf57	124989	broad.mit.edu	37	17	45471364	45471364	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:45471364delA	uc002iln.2	+						C17orf57_uc002ilm.2_Intron	NM_152347	NP_689560			hypothetical protein LOC124989								calcium ion binding			breast(1)|central_nervous_system(1)|skin(1)	3																		---	---	---	---
LRRC46	90506	broad.mit.edu	37	17	45914099	45914099	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:45914099delC	uc002ima.2	+						LRRC46_uc002imb.2_Intron	NM_033413	NP_219481			leucine rich repeat containing 46											ovary(1)	1																		---	---	---	---
SKAP1	8631	broad.mit.edu	37	17	46248024	46248024	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:46248024delG	uc002ini.1	-						SKAP1_uc002inj.1_Intron|SKAP1_uc010dbd.1_Intron|SKAP1_uc010dbe.1_Intron	NM_003726	NP_003717			src kinase associated phosphoprotein 1 isoform						positive regulation of transcription from RNA polymerase II promoter|T cell receptor signaling pathway	cytoplasm|nucleus|plasma membrane	antigen binding|protein kinase binding|SH2 domain binding				0																		---	---	---	---
ABI3	51225	broad.mit.edu	37	17	47295005	47295005	+	Intron	DEL	C	-	-	rs113223751		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:47295005delC	uc002iop.1	+						ABI3_uc002ioq.1_Intron	NM_016428	NP_057512			NESH protein isoform 1						cellular component movement|regulation of cell migration	cytoplasm|lamellipodium	protein binding				0			Epithelial(5;6.37e-06)|all cancers(6;6.36e-05)												HNSCC(55;0.14)			---	---	---	---
COL1A1	1277	broad.mit.edu	37	17	48276750	48276750	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:48276750delC	uc002iqm.2	-							NM_000088	NP_000079			alpha 1 type I collagen preproprotein						axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(372)	soft_tissue(372)|central_nervous_system(7)|skin(1)|breast(1)|pancreas(1)	382					Collagenase(DB00048)|Palifermin(DB00039)			T	PDGFB|USP6	dermatofibrosarcoma protuberans|aneurysmal bone cyst 		Osteogenesis imperfecta						---	---	---	---
Unknown	0	broad.mit.edu	37	17	51834303	51834303	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:51834303delT								None (None upstream) : KIF2B (65936 downstream)																																			---	---	---	---
TOM1L1	10040	broad.mit.edu	37	17	52981023	52981023	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:52981023delT	uc002iud.2	+						TOM1L1_uc002iub.2_Intron|TOM1L1_uc002iuc.2_Intron|TOM1L1_uc010dca.1_Intron|TOM1L1_uc010wnb.1_Intron|TOM1L1_uc010wnc.1_Intron|TOM1L1_uc010dbz.2_Intron|TOM1L1_uc010wnd.1_Intron	NM_005486	NP_005477			target of myb1-like 1						intracellular protein transport|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	cytosol|endosome membrane|Golgi stack|lysosome	SH3 domain binding|ubiquitin binding			ovary(1)	1																		---	---	---	---
STXBP4	252983	broad.mit.edu	37	17	53076905	53076905	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:53076905delT	uc002iuf.1	+						STXBP4_uc010dcc.1_Intron|STXBP4_uc010dcd.1_Intron	NM_178509	NP_848604			syntaxin binding protein 4							cytoplasm	calcium ion binding			ovary(1)	1																		---	---	---	---
MMD	23531	broad.mit.edu	37	17	53485194	53485194	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:53485194delA	uc002iui.2	-							NM_012329	NP_036461			monocyte to macrophage						cytolysis	integral to plasma membrane|late endosome membrane|lysosomal membrane|membrane fraction	receptor activity				0																		---	---	---	---
PCTP	58488	broad.mit.edu	37	17	53852255	53852255	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:53852255delG	uc002iul.3	+						PCTP_uc002ium.3_Intron|PCTP_uc010dcg.2_Intron|PCTP_uc010dch.2_Intron	NM_021213	NP_067036			phosphatidylcholine transfer protein isoform 1							cytosol	phosphatidylcholine binding|phosphatidylcholine transmembrane transporter activity			lung(1)	1			BRCA - Breast invasive adenocarcinoma(1;0.00207)															---	---	---	---
DGKE	8526	broad.mit.edu	37	17	54926518	54926518	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:54926518delT	uc002iur.2	+						DGKE_uc002ius.1_Intron	NM_003647	NP_003638			diacylglycerol kinase epsilon						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|phospholipid biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding|protein binding			breast(2)	2	Breast(9;3.59e-07)																	---	---	---	---
MSI2	124540	broad.mit.edu	37	17	55334367	55334367	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:55334367delC	uc002iuz.1	+						MSI2_uc010wnm.1_Intron|MSI2_uc002iva.2_5'Flank	NM_138962	NP_620412			musashi 2 isoform a							cytoplasm	nucleotide binding|RNA binding			central_nervous_system(1)|pancreas(1)	2	Breast(9;1.78e-08)			GBM - Glioblastoma multiforme(1;0.0025)				T	HOXA9	CML								---	---	---	---
RNF43	54894	broad.mit.edu	37	17	56435161	56435161	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:56435161delC	uc002iwf.2	-	8	3932	c.1976delG	c.(1975-1977)GGTfs	p.G659fs	RNF43_uc010wnv.1_Frame_Shift_Del_p.G618fs|RNF43_uc002iwh.3_Frame_Shift_Del_p.G659fs|RNF43_uc002iwg.3_Frame_Shift_Del_p.G659fs|RNF43_uc010dcw.2_Frame_Shift_Del_p.G532fs	NM_017763	NP_060233	Q68DV7	RNF43_HUMAN	ring finger protein 43 precursor	659	Pro-rich.|Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			ovary(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)																	---	---	---	---
HSF5	124535	broad.mit.edu	37	17	56554230	56554231	+	Intron	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:56554230_56554231delTT	uc002iwi.1	-							NM_001080439	NP_001073908			heat shock transcription factor family member 5							nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)																	---	---	---	---
TRIM37	4591	broad.mit.edu	37	17	57126492	57126492	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:57126492delT	uc002iwy.3	-						TRIM37_uc002iwz.3_Intron|TRIM37_uc002ixa.3_Intron|TRIM37_uc010woc.1_Intron	NM_001005207	NP_001005207			tripartite motif-containing 37 protein							perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			lung(2)|pancreas(2)|ovary(1)|skin(1)|breast(1)	7	Medulloblastoma(34;0.0922)|all_neural(34;0.101)													Mulibrey_Nanism				---	---	---	---
TRIM37	4591	broad.mit.edu	37	17	57139823	57139823	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:57139823delA	uc002iwy.3	-						TRIM37_uc002iwz.3_Intron|TRIM37_uc002ixa.3_Intron|TRIM37_uc010woc.1_Intron	NM_001005207	NP_001005207			tripartite motif-containing 37 protein							perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			lung(2)|pancreas(2)|ovary(1)|skin(1)|breast(1)	7	Medulloblastoma(34;0.0922)|all_neural(34;0.101)													Mulibrey_Nanism				---	---	---	---
SKA2	348235	broad.mit.edu	37	17	57208610	57208610	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:57208610delT	uc002ixd.2	-						SKA2_uc002ixc.2_Intron|SKA2_uc010dde.1_Intron|SKA2_uc002ixe.2_Intron	NM_182620	NP_872426			spindle and KT associated 2 isoform 1						cell division|chromosome segregation|mitotic anaphase|mitotic prometaphase|regulation of microtubule polymerization or depolymerization	condensed chromosome outer kinetochore|cytosol|spindle microtubule	microtubule binding				0																		---	---	---	---
CLTC	1213	broad.mit.edu	37	17	57725154	57725154	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:57725154delT	uc002ixq.1	+						CLTC_uc002ixp.2_Intron|CLTC_uc002ixr.1_Intron	NM_004859	NP_004850			clathrin heavy chain 1						axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	haematopoietic_and_lymphoid_tissue(33)|soft_tissue(11)|kidney(2)|ovary(1)|breast(1)	48	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)							T	ALK|TFE3	ALCL|renal 								---	---	---	---
RPS6KB1	6198	broad.mit.edu	37	17	57991981	57991981	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:57991981delT	uc002ixy.2	+						RPS6KB1_uc010ddj.1_Intron|RPS6KB1_uc010wom.1_Intron|RPS6KB1_uc010won.1_Intron|RPS6KB1_uc010woo.1_Intron	NM_003161	NP_003152			ribosomal protein S6 kinase, 70kDa, polypeptide						apoptosis|G1/S transition of mitotic cell cycle|insulin receptor signaling pathway|negative regulation of apoptosis|phosphatidylinositol-mediated signaling|positive regulation of mitotic cell cycle|positive regulation of translational initiation|TOR signaling cascade	cell junction|cytoplasm|cytosol|mitochondrial outer membrane|nucleus|nucleus|synapse|synaptosome	ATP binding|protein binding|protein kinase activity			large_intestine(1)	1	all_cancers(5;1.63e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.57e-12)|all cancers(12;6.41e-11)															---	---	---	---
HEATR6	63897	broad.mit.edu	37	17	58137628	58137628	+	Intron	DEL	A	-	-	rs67240321		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:58137628delA	uc002iyk.1	-						HEATR6_uc010ddk.1_Intron|HEATR6_uc010wos.1_Intron	NM_022070	NP_071353			HEAT repeat containing 6								binding			ovary(1)|skin(1)	2	all_cancers(5;2.25e-13)|Breast(5;4.84e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		BRCA - Breast invasive adenocarcinoma(1;5.93e-19)|Epithelial(12;7.59e-12)|all cancers(12;1.26e-10)															---	---	---	---
USP32	84669	broad.mit.edu	37	17	58297180	58297180	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:58297180delA	uc002iyo.1	-						USP32_uc002iyn.1_Intron	NM_032582	NP_115971			ubiquitin specific protease 32						protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)															---	---	---	---
BCAS3	54828	broad.mit.edu	37	17	59115099	59115100	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:59115099_59115100insA	uc002iyv.3	+						BCAS3_uc010wow.1_Intron|BCAS3_uc002iyu.3_Intron|BCAS3_uc002iyw.3_Intron|BCAS3_uc002iyy.3_Intron|BCAS3_uc002iyz.3_Intron|BCAS3_uc002iza.3_Intron	NM_001099432	NP_001092902			breast carcinoma amplified sequence 3 isoform 1							nucleus				ovary(2)|central_nervous_system(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)															---	---	---	---
BRIP1	83990	broad.mit.edu	37	17	59760492	59760492	+	3'UTR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:59760492delA	uc002izk.1	-	20						NM_032043	NP_114432			BRCA1 interacting protein C-terminal helicase 1						DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(1)	1								F|N|Mis			AML|leukemia|breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				---	---	---	---
INTS2	57508	broad.mit.edu	37	17	59974795	59974795	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:59974795delT	uc002izn.2	-						INTS2_uc002izm.2_Intron	NM_020748	NP_065799			integrator complex subunit 2						snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			ovary(1)|lung(1)|pancreas(1)	3																		---	---	---	---
HELZ	9931	broad.mit.edu	37	17	65105425	65105425	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:65105425delA	uc010wqk.1	-	29	4486	c.4299delT	c.(4297-4299)TTTfs	p.F1433fs	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Frame_Shift_Del_p.F1432fs|HELZ_uc010der.2_5'UTR	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)																	---	---	---	---
HELZ	9931	broad.mit.edu	37	17	65156366	65156366	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:65156366delA	uc010wqk.1	-						HELZ_uc002jfv.3_Intron|HELZ_uc002jfx.3_Intron	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)																	---	---	---	---
BPTF	2186	broad.mit.edu	37	17	65905565	65905567	+	Intron	DEL	TTT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:65905565_65905567delTTT	uc002jgf.2	+						BPTF_uc002jge.2_Intron	NM_182641	NP_872579			bromodomain PHD finger transcription factor						brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)															---	---	---	---
ABCA9	10350	broad.mit.edu	37	17	67023743	67023743	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:67023743delT	uc002jhu.2	-						ABCA9_uc010dez.2_Intron	NM_080283	NP_525022			ATP-binding cassette, sub-family A, member 9						transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)																	---	---	---	---
ABCA10	10349	broad.mit.edu	37	17	67197935	67197935	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:67197935delT	uc010dfa.1	-						ABCA10_uc010wqt.1_Intron|ABCA10_uc010dfb.1_Intron|ABCA10_uc010dfc.1_Intron	NM_080282	NP_525021			ATP-binding cassette, sub-family A, member 10						transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)																	---	---	---	---
Unknown	0	broad.mit.edu	37	17	67703228	67703228	+	IGR	DEL	T	-	-	rs79991562		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:67703228delT								MAP2K6 (164766 upstream) : KCNJ16 (368198 downstream)																																			---	---	---	---
DNAI2	64446	broad.mit.edu	37	17	72277776	72277776	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:72277776delT	uc002jkf.2	+						DNAI2_uc002jkg.2_Intron|DNAI2_uc010dfp.2_Intron	NM_023036	NP_075462			dynein, axonemal, intermediate polypeptide 2						cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			ovary(2)|central_nervous_system(1)	3														Kartagener_syndrome				---	---	---	---
Unknown	0	broad.mit.edu	37	17	73231941	73231941	+	IGR	DEL	T	-	-	rs71898043		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73231941delT								NUP85 (87 upstream) : GGA3 (754 downstream)																																			---	---	---	---
GALK1	2584	broad.mit.edu	37	17	73759757	73759757	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73759757delA	uc010wsi.1	-						GALK1_uc002jpk.2_Intron|GALK1_uc010wsj.1_Intron	NM_000154	NP_000145			galactokinase 1						galactose catabolic process	cytosol	ATP binding|galactokinase activity|galactose binding				0	all_cancers(13;1.5e-07)		all cancers(21;1.03e-06)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)															---	---	---	---
RNF157	114804	broad.mit.edu	37	17	74162632	74162632	+	Intron	DEL	A	-	-	rs67444473		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:74162632delA	uc002jqz.2	-						RNF157_uc002jra.2_Intron	NM_052916	NP_443148			ring finger protein 157								zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(166;0.187)															---	---	---	---
CYTH1	9267	broad.mit.edu	37	17	76694216	76694217	+	Intron	DEL	CA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:76694216_76694217delCA	uc002jvw.2	-							NM_017456	NP_059430			cytohesin 1 isoform 2						regulation of ARF protein signal transduction|regulation of cell adhesion|vesicle-mediated transport	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1																		---	---	---	---
USP36	57602	broad.mit.edu	37	17	76794434	76794435	+	3'UTR	INS	-	CA	CA			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:76794434_76794435insCA	uc002jvz.1	-	20					USP36_uc002jwa.1_Intron|USP36_uc002jvy.1_Intron	NM_025090	NP_079366			ubiquitin specific peptidase 36						ubiquitin-dependent protein catabolic process	nucleolus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)|breast(1)|kidney(1)	5			BRCA - Breast invasive adenocarcinoma(99;0.000842)|OV - Ovarian serous cystadenocarcinoma(97;0.151)															---	---	---	---
FLJ35220	284131	broad.mit.edu	37	17	78396091	78396091	+	Intron	DEL	C	-	-	rs9907097	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:78396091delC	uc002jym.1	+						FLJ35220_uc002jyk.2_Intron|FLJ35220_uc002jyl.1_Intron|FLJ35220_uc002jyn.2_Intron	NM_173627	NP_775898			hypothetical protein LOC284131 isoform 1						DNA repair		endodeoxyribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding				0	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0487)										Direct_reversal_of_damage|Editing_and_processing_nucleases					---	---	---	---
RPTOR	57521	broad.mit.edu	37	17	78919392	78919392	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:78919392delA	uc002jyt.1	+						RPTOR_uc010wug.1_Intron	NM_020761	NP_065812			raptor isoform 1						cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			lung(4)|urinary_tract(1)|ovary(1)	6																		---	---	---	---
NARF	26502	broad.mit.edu	37	17	80426633	80426635	+	Intron	DEL	CTT	-	-	rs2306752	byFrequency;by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:80426633_80426635delCTT	uc002kfg.3	+						NARF_uc002kff.3_Intron|NARF_uc010wvo.1_Intron|NARF_uc010wvp.1_Intron|NARF_uc010dit.2_Intron|NARF_uc002kfj.3_Intron|NARF_uc002kfi.3_Intron|NARF_uc002kfh.3_Intron|NARF_uc002kfk.2_Intron	NM_012336	NP_036468			nuclear prelamin A recognition factor isoform a							lamin filament	lamin binding			skin(1)	1	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.0143)|BRCA - Breast invasive adenocarcinoma(99;0.0369)															---	---	---	---
WDR45L	56270	broad.mit.edu	37	17	80574645	80574645	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:80574645delT	uc002kfq.2	-						WDR45L_uc002kfr.2_Intron	NM_019613	NP_062559			WDR45-like						autophagy|response to starvation	organelle membrane	phosphatidylinositol-3,5-bisphosphate binding			ovary(1)	1	Breast(20;0.00106)|all_neural(118;0.0952)	all_cancers(8;0.101)|all_epithelial(8;0.198)	BRCA - Breast invasive adenocarcinoma(99;0.0262)|OV - Ovarian serous cystadenocarcinoma(97;0.0835)															---	---	---	---
LOC727896	727896	broad.mit.edu	37	18	2946534	2946534	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:2946534delT	uc010wyu.1	-	1	88	c.1delA	c.(1-3)ATGfs	p.M1fs	LPIN2_uc002klo.2_Intron	NR_026659				Homo sapiens cDNA clone IMAGE:4614712, containing frame-shift errors.												0																		---	---	---	---
MYL12B	103910	broad.mit.edu	37	18	3273142	3273142	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:3273142delT	uc010dkl.2	+						MYL12B_uc002klt.3_Intron|MYL12B_uc010wyv.1_Intron	NM_001144944	NP_001138416			myosin regulatory light chain MRCL2 isoform A						axon guidance|muscle contraction	cytosol|myosin complex	calcium ion binding				0																		---	---	---	---
ARHGAP28	79822	broad.mit.edu	37	18	6881998	6881998	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:6881998delA	uc010wzi.1	+						ARHGAP28_uc002knc.2_Intron|ARHGAP28_uc002knd.2_Intron|ARHGAP28_uc002kne.2_Intron|ARHGAP28_uc002knf.2_Intron					SubName: Full=Putative uncharacterized protein ARHGAP28;						signal transduction	intracellular				pancreas(1)	1		Colorectal(10;0.168)																---	---	---	---
LAMA1	284217	broad.mit.edu	37	18	7064220	7064221	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:7064220_7064221insA	uc002knm.2	-						LAMA1_uc010wzj.1_Intron	NM_005559	NP_005550			laminin, alpha 1 precursor						axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
PTPRM	5797	broad.mit.edu	37	18	8379454	8379454	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:8379454delT	uc002knn.3	+						PTPRM_uc010dkv.2_Intron|PTPRM_uc010wzl.1_Intron	NM_002845	NP_002836			protein tyrosine phosphatase, receptor type, M						homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)																---	---	---	---
ANKRD12	23253	broad.mit.edu	37	18	9263859	9263861	+	In_Frame_Del	DEL	ACT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:9263859_9263861delACT	uc002knv.2	+	10	5993_5995	c.5736_5738delACT	c.(5734-5739)AAACTA>AAA	p.L1913del	ANKRD12_uc002knw.2_In_Frame_Del_p.L1890del|ANKRD12_uc002knx.2_In_Frame_Del_p.L1890del	NM_015208	NP_056023	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12 isoform 1	1913						nucleus				ovary(2)|central_nervous_system(1)	3																		---	---	---	---
CEP76	79959	broad.mit.edu	37	18	12699312	12699312	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:12699312delA	uc002kri.2	-						PSMG2_uc002krg.2_Intron|CEP76_uc002krh.3_Intron|CEP76_uc010wzz.1_Intron|CEP76_uc010xaa.1_Intron|CEP76_uc010xab.1_Intron	NM_024899	NP_079175			centrosomal protein 76kDa						G2/M transition of mitotic cell cycle|regulation of centriole replication	centriole|cytosol	protein binding				0																		---	---	---	---
CEP192	55125	broad.mit.edu	37	18	13113387	13113387	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:13113387delA	uc010xac.1	+						CEP192_uc010dlf.1_Intron|CEP192_uc010xad.1_Intron|CEP192_uc002kru.2_Intron|CEP192_uc002krv.2_Intron|CEP192_uc002krw.2_Intron|CEP192_uc002krx.2_Intron|CEP192_uc002kry.2_Intron	NM_032142	NP_115518			centrosomal protein 192kDa											ovary(4)|pancreas(1)	5																		---	---	---	---
ZNF519	162655	broad.mit.edu	37	18	14124177	14124179	+	Intron	DEL	AAA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:14124177_14124179delAAA	uc002kst.1	-						ZNF519_uc002ksq.1_Intron|ZNF519_uc002ksr.1_Intron|ZNF519_uc010dlm.1_Intron	NM_145287	NP_660330			zinc finger protein 519						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	18	14198263	14198263	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:14198263delT								ZNF519 (65834 upstream) : LOC284233 (139159 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	18	14613735	14613735	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:14613735delT								POTEC (70136 upstream) : ANKRD30B (134504 downstream)																																			---	---	---	---
ESCO1	114799	broad.mit.edu	37	18	19144359	19144360	+	Intron	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:19144359_19144360delTT	uc002kth.1	-						ESCO1_uc002kti.1_Intron	NM_052911	NP_443143			establishment of cohesion 1 homolog 1						cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding				0																		---	---	---	---
MIB1	57534	broad.mit.edu	37	18	19437240	19437240	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:19437240delT	uc002ktq.2	+						MIB1_uc002ktp.2_Intron	NM_020774	NP_065825			mindbomb homolog 1						Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(4)	4			STAD - Stomach adenocarcinoma(5;0.212)															---	---	---	---
AQP4	361	broad.mit.edu	37	18	24442217	24442217	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:24442217delC	uc002kwa.2	-	2	439	c.376delG	c.(376-378)GCCfs	p.A126fs	AQP4_uc002kvz.2_Frame_Shift_Del_p.A104fs	NM_001650	NP_001641	P55087	AQP4_HUMAN	aquaporin 4 isoform a	126	Helical; (Potential).				cellular response to interferon-gamma|excretion|nervous system development	cytoplasm|external side of plasma membrane|integral to plasma membrane	water channel activity				0	all_cancers(21;0.0172)|Lung NSC(5;0.00299)|all_lung(6;0.00747)|Ovarian(20;0.124)																	---	---	---	---
FAM59A	64762	broad.mit.edu	37	18	29848873	29848873	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:29848873delT	uc002kxl.2	-						FAM59A_uc002kxk.1_Intron	NM_022751	NP_073588			family with sequence similarity 59, member A											ovary(1)|skin(1)	2																		---	---	---	---
MAPRE2	10982	broad.mit.edu	37	18	32711893	32711894	+	Intron	INS	-	TC	TC	rs150523385	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:32711893_32711894insTC	uc002kyg.2	+						MAPRE2_uc010xcb.1_Intron|MAPRE2_uc010xcc.1_Intron|MAPRE2_uc002kyh.2_Intron|MAPRE2_uc010xcd.1_Intron	NM_014268	NP_055083			microtubule-associated protein, RP/EB family,						cell division|cell proliferation|mitosis|signal transduction	cytoplasm|microtubule	microtubule binding			ovary(1)	1																		---	---	---	---
GALNT1	2589	broad.mit.edu	37	18	33289488	33289488	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:33289488delA	uc010dmu.2	+						GALNT1_uc002kyz.3_Intron|GALNT1_uc002kzb.2_Intron	NM_020474	NP_065207			polypeptide N-acetylgalactosaminyltransferase 1						protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2																		---	---	---	---
SLC39A6	25800	broad.mit.edu	37	18	33690943	33690943	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:33690943delA	uc010dmy.2	-							NM_012319	NP_036451			solute carrier family 39 (zinc transporter),							integral to membrane|lamellipodium membrane	zinc ion transmembrane transporter activity			ovary(1)|pancreas(1)	2																		---	---	---	---
SLC39A6	25800	broad.mit.edu	37	18	33704301	33704302	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:33704301_33704302insT	uc010dmy.2	-						SLC39A6_uc002kzj.2_Intron	NM_012319	NP_036451			solute carrier family 39 (zinc transporter),							integral to membrane|lamellipodium membrane	zinc ion transmembrane transporter activity			ovary(1)|pancreas(1)	2																		---	---	---	---
ELP2	55250	broad.mit.edu	37	18	33738964	33738964	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:33738964delT	uc002kzk.1	+						ELP2_uc010xcg.1_Intron|ELP2_uc002kzl.1_Intron|ELP2_uc002kzm.1_Intron|ELP2_uc010xch.1_Intron|ELP2_uc002kzn.1_Intron|ELP2_uc002kzo.1_Intron	NM_018255	NP_060725			elongator protein 2						regulation of transcription from RNA polymerase II promoter	Golgi apparatus|transcription elongation factor complex				breast(2)|ovary(1)|skin(1)	4																		---	---	---	---
PIK3C3	5289	broad.mit.edu	37	18	39620447	39620447	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:39620447delA	uc002lap.2	+						PIK3C3_uc010xcl.1_Intron|PIK3C3_uc002laq.2_Intron|PIK3C3_uc002lar.1_Intron	NM_002647	NP_002638			catalytic phosphatidylinositol 3-kinase 3						cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			lung(8)|ovary(1)|breast(1)	10															TSP Lung(28;0.18)			---	---	---	---
RIT2	6014	broad.mit.edu	37	18	40500908	40500909	+	Intron	DEL	TT	-	-	rs78182517		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:40500908_40500909delTT	uc002lav.2	-						RIT2_uc010dnf.2_Intron	NM_002930	NP_002921			Ras-like without CAAX 2						nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction|synaptic transmission	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity			ovary(1)	1																		---	---	---	---
SLC14A1	6563	broad.mit.edu	37	18	43328619	43328619	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:43328619delA	uc010xcn.1	+						SLC14A1_uc010dnk.2_Intron|SLC14A1_uc002lbf.3_Intron|SLC14A1_uc002lbg.3_Intron|SLC14A1_uc010xco.1_Intron|SLC14A1_uc002lbh.3_Intron|SLC14A1_uc002lbi.3_Intron|SLC14A1_uc002lbj.3_Intron|SLC14A1_uc002lbk.3_Intron	NM_001146036	NP_001139508			solute carrier family 14 (urea transporter),							integral to plasma membrane	urea transmembrane transporter activity			central_nervous_system(1)|pancreas(1)	2																		---	---	---	---
KIAA1632	57724	broad.mit.edu	37	18	43495620	43495620	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:43495620delT	uc002lbm.2	-						KIAA1632_uc002lbo.1_Intron|KIAA1632_uc010xcq.1_Intron|KIAA1632_uc010xcr.1_Intron|KIAA1632_uc010xcs.1_Intron|KIAA1632_uc002lbn.2_Intron	NM_020964	NP_066015			hypothetical protein LOC57724						autophagy						0																		---	---	---	---
HAUS1	115106	broad.mit.edu	37	18	43700206	43700207	+	Intron	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:43700206_43700207delTT	uc002lbu.2	+						HAUS1_uc002lbv.2_Intron	NM_138443	NP_612452			coiled-coil domain containing 5						cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle pole				ovary(1)	1																		---	---	---	---
HAUS1	115106	broad.mit.edu	37	18	43703177	43703177	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:43703177delA	uc002lbu.2	+						HAUS1_uc002lbv.2_Intron	NM_138443	NP_612452			coiled-coil domain containing 5						cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle pole				ovary(1)	1																		---	---	---	---
MYO5B	4645	broad.mit.edu	37	18	47501036	47501036	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:47501036delC	uc002leb.2	-						MYO5B_uc002lec.1_Intron	NM_001080467	NP_001073936			myosin VB						protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)														---	---	---	---
Unknown	0	broad.mit.edu	37	18	49048663	49048664	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:49048663_49048664insT	uc010xdq.1	+											Homo sapiens cDNA FLJ37617 fis, clone BRCOC2012229.																														---	---	---	---
DCC	1630	broad.mit.edu	37	18	50554196	50554196	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:50554196delT	uc002lfe.1	+						DCC_uc010xdr.1_Intron|DCC_uc010dpf.1_Intron	NM_005215	NP_005206			netrin receptor DCC precursor						apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)														---	---	---	---
DCC	1630	broad.mit.edu	37	18	50942485	50942485	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:50942485delC	uc002lfe.1	+						DCC_uc010xdr.1_Intron|DCC_uc010dpf.1_Intron	NM_005215	NP_005206			netrin receptor DCC precursor						apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)														---	---	---	---
TCF4	6925	broad.mit.edu	37	18	53254233	53254234	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:53254233_53254234insT	uc002lfz.2	-						TCF4_uc010xdx.1_5'Flank|TCF4_uc010dph.1_Intron|TCF4_uc010xdy.1_Intron|TCF4_uc002lga.2_Intron|TCF4_uc010dpi.2_Intron	NM_003199	NP_003190			transcription factor 4 isoform b						positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding			ovary(1)|lung(1)	2				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)														---	---	---	---
TXNL1	9352	broad.mit.edu	37	18	54278334	54278334	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:54278334delA	uc002lgg.2	-						TXNL1_uc010xdz.1_Intron|TXNL1_uc002lgh.2_Intron|TXNL1_uc002lgi.2_Intron|TXNL1_uc002lgj.1_Intron	NM_004786	NP_004777			thioredoxin-like 1						cell redox homeostasis|electron transport chain|glycerol ether metabolic process|transport	cytoplasm	electron carrier activity|protein disulfide oxidoreductase activity				0				READ - Rectum adenocarcinoma(59;0.193)|Colorectal(16;0.211)														---	---	---	---
TXNL1	9352	broad.mit.edu	37	18	54283634	54283635	+	Intron	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:54283634_54283635delAA	uc002lgg.2	-						TXNL1_uc010xdz.1_Intron|TXNL1_uc002lgh.2_Intron|TXNL1_uc002lgi.2_Intron|TXNL1_uc002lgj.1_Intron	NM_004786	NP_004777			thioredoxin-like 1						cell redox homeostasis|electron transport chain|glycerol ether metabolic process|transport	cytoplasm	electron carrier activity|protein disulfide oxidoreductase activity				0				READ - Rectum adenocarcinoma(59;0.193)|Colorectal(16;0.211)														---	---	---	---
Unknown	0	broad.mit.edu	37	18	55399268	55399269	+	Intron	INS	-	A	A	rs66955564	by1000genomes;byFrequency;by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:55399268_55399269insA	uc002lgv.1	+						ATP8B1_uc002lgw.2_5'Flank					Homo sapiens cDNA FLJ31469 fis, clone NT2NE2001428.																														---	---	---	---
ZNF532	55205	broad.mit.edu	37	18	56651741	56651741	+	3'UTR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:56651741delA	uc002lho.2	+	11					ZNF532_uc002lhp.2_3'UTR|ZNF532_uc010xeg.1_3'UTR|ZNF532_uc002lhr.2_3'UTR|ZNF532_uc002lhs.2_3'UTR|ZNF532_uc010xeh.1_3'UTR	NM_018181	NP_060651			zinc finger protein 532						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	18	57863630	57863630	+	IGR	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:57863630delC								PMAIP1 (292092 upstream) : MC4R (174934 downstream)																																			---	---	---	---
DSEL	92126	broad.mit.edu	37	18	65179868	65179869	+	Frame_Shift_Ins	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:65179868_65179869insT	uc002lke.1	-	2	3231_3232	c.2007_2008insA	c.(2005-2010)AAACGAfs	p.K669fs		NM_032160	NP_115536	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	659_660						integral to membrane	isomerase activity|sulfotransferase activity			ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	6		Esophageal squamous(42;0.129)																---	---	---	---
TMX3	54495	broad.mit.edu	37	18	66365154	66365154	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:66365154delA	uc002lkf.2	-						TMX3_uc010xez.1_Intron|TMX3_uc010xfa.1_Intron|TMX3_uc002lkg.3_Intron	NM_019022	NP_061895			thioredoxin domain containing 10 precursor						cell redox homeostasis|glycerol ether metabolic process	endoplasmic reticulum membrane|integral to membrane	electron carrier activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			skin(1)	1																		---	---	---	---
CCDC102B	79839	broad.mit.edu	37	18	66503864	66503867	+	Intron	DEL	AAAT	-	-	rs71369199	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:66503864_66503867delAAAT	uc002lkk.2	+						CCDC102B_uc002lki.2_Intron|CCDC102B_uc002lkj.1_Intron	NM_001093729	NP_001087198			coiled-coil domain containing 102B											ovary(1)|lung(1)|skin(1)	3		Esophageal squamous(42;0.0559)|Colorectal(73;0.0604)																---	---	---	---
SHC2	25759	broad.mit.edu	37	19	425077	425077	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:425077delC	uc002loq.3	-						SHC2_uc002lop.3_Intron	NM_012435	NP_036567			SHC (Src homology 2 domain containing)						insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol					0		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
HCN2	610	broad.mit.edu	37	19	613827	613828	+	Intron	INS	-	C	C	rs143893727	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:613827_613828insC	uc002lpe.2	+							NM_001194	NP_001185			hyperpolarization activated cyclic						cell-cell signaling|muscle contraction	voltage-gated potassium channel complex	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity				0		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
AZU1	566	broad.mit.edu	37	19	831081	831082	+	Intron	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:831081_831082delTT	uc002lpz.1	+							NM_001700	NP_001691			azurocidin 1 preproprotein						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cellular extravasation|defense response to Gram-negative bacterium|glial cell migration|induction of positive chemotaxis|inflammatory response|macrophage chemotaxis|microglial cell activation|monocyte activation|positive regulation of cell adhesion|positive regulation of fractalkine biosynthetic process|positive regulation of interleukin-1 beta biosynthetic process|positive regulation of MHC class II biosynthetic process|positive regulation of phagocytosis|positive regulation of tumor necrosis factor biosynthetic process|proteolysis|regulation of vascular permeability	azurophil granule|extracellular region	heparin binding|serine-type endopeptidase activity|toxin binding			pancreas(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
TLE6	79816	broad.mit.edu	37	19	2994886	2994886	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:2994886delC	uc002lwu.2	+						TLE6_uc002lwt.2_Intron|TLE6_uc010dtg.2_Intron|TLE6_uc002lwv.2_Intron	NM_024760	NP_079036			transducin-like enhancer of split 6 isoform 2						regulation of transcription, DNA-dependent	nucleus				ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
ZFR2	23217	broad.mit.edu	37	19	3871980	3871981	+	5'Flank	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:3871980_3871981delAA	uc002lyw.2	-						ZFR2_uc010xhx.1_5'Flank|ZFR2_uc002lyx.3_5'Flank|ZFR2_uc010xhy.1_5'Flank	NM_015174	NP_055989			zinc finger RNA binding protein 2 isoform 1							intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)														---	---	---	---
PTPRS	5802	broad.mit.edu	37	19	5212311	5212311	+	Intron	DEL	G	-	-	rs45439595	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:5212311delG	uc002mbv.2	-						PTPRS_uc002mbu.1_Intron|PTPRS_uc010xin.1_Intron|PTPRS_uc002mbw.2_Intron|PTPRS_uc002mbx.2_Intron|PTPRS_uc002mby.2_Intron	NM_002850	NP_002841			protein tyrosine phosphatase, receptor type,						cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)														---	---	---	---
KHSRP	8570	broad.mit.edu	37	19	6414076	6414076	+	3'UTR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6414076delA	uc002mer.3	-	20						NM_003685	NP_003676			KH-type splicing regulatory protein						mRNA processing|mRNA transport|regulation of transcription, DNA-dependent|RNA splicing, via transesterification reactions|transcription, DNA-dependent	cytosol|nucleus	DNA binding|protein binding|RNA binding			skin(1)	1																		---	---	---	---
DENND1C	79958	broad.mit.edu	37	19	6477590	6477590	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6477590delT	uc002mfe.2	-						DENND1C_uc002mfb.2_5'Flank|DENND1C_uc002mfc.2_5'Flank|DENND1C_uc002mfd.2_Intron|DENND1C_uc010xje.1_Intron	NM_024898	NP_079174			DENN/MADD domain containing 1C							clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			large_intestine(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	19	6562609	6562609	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6562609delT								TNFSF9 (26670 upstream) : CD70 (20526 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	19	7879381	7879381	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:7879381delT								CLEC4GP1 (23483 upstream) : EVI5L (15780 downstream)																																			---	---	---	---
MAP2K7	5609	broad.mit.edu	37	19	7976122	7976122	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:7976122delC	uc002mit.2	+						MAP2K7_uc002miv.2_Intron|MAP2K7_uc010xka.1_Intron|MAP2K7_uc010xkb.1_Intron|MAP2K7_uc010dvv.2_Intron	NM_145185	NP_660186			mitogen-activated protein kinase kinase 7						activation of JUN kinase activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleus	ATP binding|JUN kinase kinase activity|magnesium ion binding|protein binding|protein kinase binding|protein phosphatase binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			large_intestine(7)|central_nervous_system(2)|ovary(1)|lung(1)	11					Etoposide(DB00773)													---	---	---	---
ZNF559	84527	broad.mit.edu	37	19	9451652	9451653	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9451652_9451653insA	uc002mlg.2	+						ZNF559_uc002mlf.2_Intron|ZNF559_uc010dwl.1_Intron|ZNF559_uc010xkn.1_Intron|ZNF559_uc010dwm.1_Intron|ZNF559_uc002mle.3_Intron|ZNF559_uc010dwk.1_Intron|ZNF559_uc002mld.2_Intron|ZNF559_uc010dwo.1_Intron|ZNF559_uc002mlh.1_Intron|ZNF177_uc002mli.2_Intron|ZNF177_uc002mlj.2_Intron	NM_032497	NP_115886			zinc finger protein 559						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	19	9794789	9794792	+	IGR	DEL	TTTT	-	-	rs111810059		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9794789_9794792delTTTT								ZNF562 (9013 upstream) : ZNF846 (68024 downstream)																																			---	---	---	---
COL5A3	50509	broad.mit.edu	37	19	10077157	10077158	+	Intron	INS	-	C	C	rs3745582	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10077157_10077158insC	uc002mmq.1	-							NM_015719	NP_056534			collagen, type V, alpha 3 preproprotein						collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)															---	---	---	---
COL5A3	50509	broad.mit.edu	37	19	10106693	10106693	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10106693delG	uc002mmq.1	-							NM_015719	NP_056534			collagen, type V, alpha 3 preproprotein						collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)															---	---	---	---
DNMT1	1786	broad.mit.edu	37	19	10260036	10260036	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10260036delA	uc002mng.2	-						DNMT1_uc010xlc.1_Intron|DNMT1_uc002mnh.2_Intron|DNMT1_uc010xld.1_Intron	NM_001379	NP_001370			DNA (cytosine-5-)-methyltransferase 1 isoform b						chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			ovary(2)|prostate(1)|lung(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)													---	---	---	---
SLC44A2	57153	broad.mit.edu	37	19	10742919	10742919	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10742919delA	uc002mpf.2	+						SLC44A2_uc002mpe.3_Intron|SLC44A2_uc002mpg.1_5'Flank	NM_020428	NP_065161			solute carrier family 44, member 2 isoform 1						positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			ovary(1)	1			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)													---	---	---	---
CCDC159	126075	broad.mit.edu	37	19	11465391	11465391	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:11465391delC	uc010xlt.1	+						LPPR2_uc002mre.1_5'Flank|LPPR2_uc002mrf.1_5'Flank	NM_001080503	NP_001073972			coiled-coil domain-containing-like											ovary(1)	1																		---	---	---	---
CCDC151	115948	broad.mit.edu	37	19	11531627	11531627	+	Intron	DEL	G	-	-	rs10421648		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:11531627delG	uc002mrs.2	-						CCDC151_uc002mrr.2_Intron|CCDC151_uc010dxz.2_Intron|RGL3_uc002mrn.2_5'Flank|RGL3_uc002mrm.2_5'Flank|RGL3_uc002mro.2_5'Flank|RGL3_uc002mrp.2_5'Flank|RGL3_uc002mrq.2_5'Flank	NM_145045	NP_659482			coiled-coil domain containing 151											ovary(1)	1																		---	---	---	---
CCDC151	115948	broad.mit.edu	37	19	11541264	11541264	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:11541264delT	uc002mrs.2	-						CCDC151_uc002mrr.2_Intron|CCDC151_uc010dxz.2_Intron	NM_145045	NP_659482			coiled-coil domain containing 151											ovary(1)	1																		---	---	---	---
ZNF490	57474	broad.mit.edu	37	19	12720211	12720211	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:12720211delA	uc002mtz.2	-						ZNF791_uc002mua.2_5'Flank|ZNF791_uc010xml.1_5'Flank|ZNF791_uc010dyu.1_5'Flank|ZNF791_uc010xmm.1_5'Flank	NM_020714	NP_065765			zinc finger protein 490						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
GCDH	2639	broad.mit.edu	37	19	13002545	13002545	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:13002545delG	uc002mvq.2	+						GCDH_uc010xms.1_Intron|GCDH_uc002mvp.2_Intron|GCDH_uc010xmt.1_5'UTR|GCDH_uc010xmu.1_Intron	NM_000159	NP_000150			glutaryl-Coenzyme A dehydrogenase isoform a						lysine catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|glutaryl-CoA dehydrogenase activity|protein binding				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	19	14997700	14997700	+	IGR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:14997700delA								OR7A17 (5533 upstream) : OR7C2 (54601 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	19	15038769	15038769	+	IGR	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:15038769delC								OR7A17 (46602 upstream) : OR7C2 (13532 downstream)																																			---	---	---	---
NWD1	284434	broad.mit.edu	37	19	16860457	16860457	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:16860457delC	uc002neu.3	+	6	1426	c.1004delC	c.(1003-1005)ACCfs	p.T335fs	NWD1_uc002net.3_Frame_Shift_Del_p.T200fs|NWD1_uc002nev.3_Frame_Shift_Del_p.T129fs			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	335	NACHT.						ATP binding			skin(3)|ovary(2)|pancreas(2)	7																		---	---	---	---
MYO9B	4650	broad.mit.edu	37	19	17308872	17308873	+	Intron	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17308872_17308873delAA	uc010eak.2	+						MYO9B_uc002nfi.2_Intron|MYO9B_uc002nfj.1_Intron|MYO9B_uc002nfl.1_5'Flank	NM_004145	NP_004136			myosin IXB isoform 1						actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1																		---	---	---	---
MYO9B	4650	broad.mit.edu	37	19	17311770	17311770	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17311770delG	uc010eak.2	+						MYO9B_uc002nfi.2_Intron|MYO9B_uc002nfj.1_Intron|MYO9B_uc002nfl.1_Intron	NM_004145	NP_004136			myosin IXB isoform 1						actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1																		---	---	---	---
USHBP1	83878	broad.mit.edu	37	19	17369974	17369974	+	Intron	DEL	A	-	-	rs80351288		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17369974delA	uc002nfs.1	-						USHBP1_uc002nfr.1_5'Flank|USHBP1_uc002nft.1_Intron|USHBP1_uc010xpk.1_Intron|USHBP1_uc010eam.1_Intron	NM_031941	NP_114147			Usher syndrome 1C binding protein 1								PDZ domain binding			ovary(1)	1																		---	---	---	---
UNC13A	23025	broad.mit.edu	37	19	17750846	17750846	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17750846delT	uc002nhd.2	-							NM_001080421	NP_001073890			unc-13 homolog A						exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3																		---	---	---	---
UNC13A	23025	broad.mit.edu	37	19	17759819	17759819	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17759819delG	uc002nhd.2	-							NM_001080421	NP_001073890			unc-13 homolog A						exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3																		---	---	---	---
JAK3	3718	broad.mit.edu	37	19	17947088	17947088	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17947088delT	uc002nhn.3	-						JAK3_uc010ebh.2_Intron|JAK3_uc002nho.2_Intron	NM_000215	NP_000206			Janus kinase 3						B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			haematopoietic_and_lymphoid_tissue(40)|lung(5)|breast(5)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	56							2	Mis		acute megakaryocytic leukemia|								---	---	---	---
Unknown	0	broad.mit.edu	37	19	18395964	18395964	+	IGR	DEL	T	-	-	rs35945463		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:18395964delT								JUND (3532 upstream) : LSM4 (21754 downstream)																																			---	---	---	---
RFXANK	8625	broad.mit.edu	37	19	19312663	19312665	+	3'UTR	DEL	CTT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19312663_19312665delCTT	uc002nls.2	+	10					RFXANK_uc002nlt.2_3'UTR|RFXANK_uc002nlu.2_3'UTR|RFXANK_uc002nlv.2_3'UTR|RFXANK_uc002nlw.2_3'UTR|NR2C2AP_uc010xqq.1_Intron|NR2C2AP_uc002nlx.2_3'UTR|NR2C2AP_uc002nly.2_3'UTR	NM_003721	NP_003712			regulatory factor X-associated							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			ovary(2)	2			Epithelial(12;0.00228)															---	---	---	---
NCAN	1463	broad.mit.edu	37	19	19348851	19348851	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19348851delA	uc002nlz.2	+						NCAN_uc010ecc.1_Intron|NCAN_uc002nma.2_5'Flank	NM_004386	NP_004377			chondroitin sulfate proteoglycan 3 precursor						axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)															---	---	---	---
SF4	57794	broad.mit.edu	37	19	19414336	19414336	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19414336delA	uc002nmh.2	-						SF4_uc002nmf.2_5'Flank|SF4_uc002nmg.2_Intron|SF4_uc002nmi.2_Intron|SF4_uc002nmj.2_Intron|SF4_uc010xqr.1_Intron|SF4_uc010xqs.1_Intron	NM_172231	NP_757386			splicing factor 4						nuclear mRNA splicing, via spliceosome	nucleoplasm|spliceosomal complex	RNA binding				0																		---	---	---	---
KIAA0892	23383	broad.mit.edu	37	19	19447109	19447109	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19447109delT	uc002nmk.3	+							NM_015329	NP_056144			hypothetical protein LOC23383 precursor						cell division|maintenance of mitotic sister chromatid cohesion	chromatin|nucleoplasm|SMC loading complex	protein N-terminus binding				0																		---	---	---	---
PBX4	80714	broad.mit.edu	37	19	19698919	19698919	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19698919delT	uc002nmy.2	-						PBX4_uc010xqz.1_Intron|PBX4_uc010xra.1_Intron	NM_025245	NP_079521			pre-B-cell leukemia homeobox 4								sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	19	19944580	19944580	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19944580delT								ZNF506 (12020 upstream) : ZNF253 (32134 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	19	20166717	20166717	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:20166717delT								ZNF682 (16440 upstream) : ZNF90 (22086 downstream)																																			---	---	---	---
ZNF708	7562	broad.mit.edu	37	19	21493258	21493258	+	Intron	DEL	T	-	-	rs669560		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:21493258delT	uc002npq.1	-						ZNF708_uc002npr.1_Intron|ZNF708_uc010ecs.1_Intron	NM_021269	NP_067092			zinc finger protein 708						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(4)|skin(2)	6																		---	---	---	---
ZNF43	7594	broad.mit.edu	37	19	22002026	22002026	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:22002026delA	uc002nqj.2	-						ZNF43_uc010ecv.2_Intron|ZNF43_uc002nql.2_Intron|ZNF43_uc002nqm.2_Intron|ZNF43_uc002nqk.2_Intron	NM_003423	NP_003414			zinc finger protein 43						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)														---	---	---	---
Unknown	0	broad.mit.edu	37	19	22321015	22321017	+	IGR	DEL	GAG	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:22321015_22321017delGAG								ZNF257 (47114 upstream) : ZNF676 (40886 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	19	23406702	23406702	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:23406702delT	uc010xri.1	-	4	463	c.345delA	c.(343-345)AAAfs	p.K115fs						SubName: Full=cDNA FLJ56866, moderately similar to Zinc finger protein 43;																														---	---	---	---
Unknown	0	broad.mit.edu	37	19	24103010	24103010	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:24103010delA	uc002nrp.1	-						uc010eda.1_RNA					Homo sapiens cDNA FLJ43698 fis, clone TCERX2000998.																														---	---	---	---
C19orf2	8725	broad.mit.edu	37	19	30476387	30476387	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:30476387delT	uc002nsr.2	+						C19orf2_uc002nsq.2_Intron|C19orf2_uc002nss.2_Intron|C19orf2_uc002nst.2_Intron	NM_003796	NP_003787			RPB5-mediating protein isoform a						protein folding|regulation of transcription from RNA polymerase II promoter|response to virus	DNA-directed RNA polymerase II, core complex|prefoldin complex	transcription corepressor activity|unfolded protein binding			ovary(1)|kidney(1)	2	Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)	Hepatocellular(1079;0.137)|Renal(1328;0.228)	STAD - Stomach adenocarcinoma(5;5.36e-06)|Lung(7;0.0144)|LUAD - Lung adenocarcinoma(5;0.115)	STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
TSHZ3	57616	broad.mit.edu	37	19	31770731	31770731	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:31770731delA	uc002nsy.3	-							NM_020856	NP_065907			zinc finger protein 537						negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)																	---	---	---	---
MLL4	9757	broad.mit.edu	37	19	36223858	36223858	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36223858delC	uc010eei.2	+	29	6408	c.6408delC	c.(6406-6408)CTCfs	p.L2136fs		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	2136					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)															---	---	---	---
WDR62	284403	broad.mit.edu	37	19	36572187	36572187	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36572187delT	uc002odc.2	+						WDR62_uc002odd.2_Intron	NM_173636	NP_775907			WD repeat domain 62 isoform 2						cerebral cortex development	nucleus					0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)															---	---	---	---
ZNF585A	199704	broad.mit.edu	37	19	37646666	37646666	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:37646666delA	uc002ofo.1	-						ZNF585A_uc002ofm.1_Intron|ZNF585A_uc002ofn.1_Intron	NM_199126	NP_954577			zinc finger protein 585A						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)															---	---	---	---
ZNF585B	92285	broad.mit.edu	37	19	37681158	37681158	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:37681158delT	uc002ofq.2	-						ZNF585B_uc002ofr.1_Intron	NM_152279	NP_689492			zinc finger protein 585B						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)															---	---	---	---
RYR1	6261	broad.mit.edu	37	19	38997257	38997258	+	Intron	INS	-	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:38997257_38997258insC	uc002oit.2	+						RYR1_uc002oiu.2_Intron|RYR1_uc002oiv.1_Intron	NM_000540	NP_000531			skeletal muscle ryanodine receptor isoform 1						muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)													---	---	---	---
RYR1	6261	broad.mit.edu	37	19	39066540	39066541	+	Intron	DEL	TC	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:39066540_39066541delTC	uc002oit.2	+						RYR1_uc002oiu.2_Intron	NM_000540	NP_000531			skeletal muscle ryanodine receptor isoform 1						muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)													---	---	---	---
CAPN12	147968	broad.mit.edu	37	19	39232227	39232229	+	Intron	DEL	AAA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:39232227_39232229delAAA	uc002ojd.1	-							NM_144691	NP_653292			calpain 12						proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			central_nervous_system(1)|pancreas(1)	2	all_cancers(60;2.87e-05)|Ovarian(47;0.0454)		Lung(45;0.00416)|LUSC - Lung squamous cell carcinoma(53;0.00741)															---	---	---	---
SIRT2	22933	broad.mit.edu	37	19	39371449	39371449	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:39371449delC	uc002ojt.1	-						RINL_uc002ojq.2_5'Flank|RINL_uc010xuo.1_5'Flank|SIRT2_uc010egh.1_Intron|SIRT2_uc010egi.1_Intron|SIRT2_uc002ojs.1_Intron|SIRT2_uc002oju.1_Intron|SIRT2_uc010egj.1_Intron|SIRT2_uc002ojv.1_Intron	NM_012237	NP_036369			sirtuin 2 isoform 1						cell division|chromatin silencing at rDNA|chromatin silencing at telomere|mitosis|negative regulation of striated muscle tissue development|protein ADP-ribosylation|regulation of exit from mitosis|regulation of phosphorylation|response to redox state	chromatin silencing complex|cytoplasm|microtubule	histone acetyltransferase binding|histone deacetylase binding|NAD+ binding|NAD-dependent histone deacetylase activity|transcription factor binding|tubulin deacetylase activity|ubiquitin binding|zinc ion binding				0	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00125)|LUSC - Lung squamous cell carcinoma(53;0.00191)															---	---	---	---
Unknown	0	broad.mit.edu	37	19	39923838	39923839	+	IGR	DEL	CA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:39923838_39923839delCA								PLEKHG2 (4784 upstream) : RPS16 (10 downstream)																																			---	---	---	---
ZNF780B	163131	broad.mit.edu	37	19	40556104	40556113	+	Intron	DEL	AAAAAAAAAA	-	-	rs74179712		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:40556104_40556113delAAAAAAAAAA	uc002omu.2	-						ZNF780B_uc002omv.2_Intron	NM_001005851	NP_001005851			zinc finger protein 780B						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)																	---	---	---	---
PLD3	23646	broad.mit.edu	37	19	40873490	40873490	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:40873490delA	uc002onm.3	+						PLD3_uc002onj.3_Intron|PLD3_uc002onk.3_Intron|PLD3_uc002onl.3_Intron|PLD3_uc002onn.2_Intron|PLD3_uc002ono.2_3'UTR	NM_001031696	NP_001026866			phospholipase D3						lipid catabolic process	endoplasmic reticulum membrane|integral to membrane	NAPE-specific phospholipase D activity|phospholipase D activity|protein binding			skin(2)|ovary(1)	3			Lung(22;0.000636)|LUSC - Lung squamous cell carcinoma(20;0.00248)															---	---	---	---
SPTBN4	57731	broad.mit.edu	37	19	41066342	41066342	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41066342delC	uc002ony.2	+						SPTBN4_uc002onx.2_Frame_Shift_Del_p.S1983fs|SPTBN4_uc002onz.2_Intron|SPTBN4_uc010egx.2_Intron|SPTBN4_uc002ooa.2_Frame_Shift_Del_p.S659fs	NM_020971	NP_066022			spectrin, beta, non-erythrocytic 4 isoform						actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)															---	---	---	---
SHKBP1	92799	broad.mit.edu	37	19	41083547	41083547	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41083547delA	uc002oob.2	+						SHKBP1_uc002ooc.2_Intron|SHKBP1_uc002ood.2_Intron|SHKBP1_uc010xvl.1_Intron|SHKBP1_uc002ooe.2_Intron|SHKBP1_uc002oof.2_Intron|SHKBP1_uc010xvm.1_5'Flank|SHKBP1_uc010xvn.1_5'Flank	NM_138392	NP_612401			SH3KBP1 binding protein 1							voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|pancreas(1)	2			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)															---	---	---	---
CYP2A6	1548	broad.mit.edu	37	19	41355987	41355988	+	Intron	DEL	CA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41355987_41355988delCA	uc002opl.3	-						CYP2A6_uc010ehe.1_Intron|CYP2A6_uc010ehf.1_Intron	NM_000762	NP_000753			cytochrome P450, family 2, subfamily A,						coumarin catabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|enzyme binding|heme binding			ovary(2)	2			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)		Chlorzoxazone(DB00356)|Diethylstilbestrol(DB00255)|Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Formoterol(DB00983)|Halothane(DB01159)|Letrozole(DB01006)|Methoxsalen(DB00553)|Metyrapone(DB01011)|Nicotine(DB00184)|Pilocarpine(DB01085)|Tolbutamide(DB01124)|Tranylcypromine(DB00752)													---	---	---	---
CYP2S1	29785	broad.mit.edu	37	19	41706982	41706982	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41706982delA	uc002opw.2	+						CYP2F1_uc010xvw.1_Intron|CYP2S1_uc010xvx.1_Intron	NM_030622	NP_085125			cytochrome P450, family 2, subfamily S,						xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity			skin(1)	1																		---	---	---	---
BCKDHA	593	broad.mit.edu	37	19	41928688	41928688	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41928688delC	uc002oqq.2	+						CYP2F1_uc010xvw.1_Intron|BCKDHA_uc002oqm.3_Intron|BCKDHA_uc002oqr.2_Intron|BCKDHA_uc010xvz.1_Intron	NM_000709	NP_000700			branched chain keto acid dehydrogenase E1, alpha						branched chain family amino acid catabolic process	mitochondrial alpha-ketoglutarate dehydrogenase complex	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|alpha-ketoacid dehydrogenase activity|carboxy-lyase activity|metal ion binding|protein binding				0																		---	---	---	---
ATP5SL	55101	broad.mit.edu	37	19	41938474	41938477	+	Intron	DEL	GTGT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41938474_41938477delGTGT	uc002oqw.1	-						CYP2F1_uc010xvw.1_Intron|ATP5SL_uc002oqu.1_Intron|ATP5SL_uc002oqv.2_Intron|ATP5SL_uc010xwa.1_Intron|ATP5SL_uc002oqx.1_Intron|ATP5SL_uc002oqy.1_Intron|ATP5SL_uc002oqz.1_Intron|ATP5SL_uc002ora.1_3'UTR|ATP5SL_uc010xwb.1_3'UTR	NM_018035	NP_060505			ATP5S-like											large_intestine(1)|breast(1)	2																		---	---	---	---
ARHGEF1	9138	broad.mit.edu	37	19	42406477	42406479	+	In_Frame_Del	DEL	GAG	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42406477_42406479delGAG	uc002orx.2	+	16	1577_1579	c.1468_1470delGAG	c.(1468-1470)GAGdel	p.E491del	ARHGEF1_uc002ory.2_In_Frame_Del_p.E458del|ARHGEF1_uc002orz.2_In_Frame_Del_p.E329del|ARHGEF1_uc002osa.2_In_Frame_Del_p.E506del|ARHGEF1_uc002osb.2_In_Frame_Del_p.E473del|ARHGEF1_uc002osc.2_In_Frame_Del_p.E245del|ARHGEF1_uc002osd.2_In_Frame_Del_p.E150del|ARHGEF1_uc002ose.2_5'Flank	NM_004706	NP_004697	Q92888	ARHG1_HUMAN	Rho guanine nucleotide exchange factor 1 isoform	491	DH.				cell proliferation|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(3)|large_intestine(1)	4		Renal(1328;0.000518)|Hepatocellular(1079;0.0046)|Medulloblastoma(540;0.0425)		Epithelial(262;5.89e-46)|GBM - Glioblastoma multiforme(1328;2.49e-12)|STAD - Stomach adenocarcinoma(1328;0.00644)														---	---	---	---
ARHGEF1	9138	broad.mit.edu	37	19	42407087	42407088	+	Intron	DEL	TT	-	-	rs76291947		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42407087_42407088delTT	uc002orx.2	+						ARHGEF1_uc002ory.2_Intron|ARHGEF1_uc002orz.2_Intron|ARHGEF1_uc002osa.2_Intron|ARHGEF1_uc002osb.2_Intron|ARHGEF1_uc002osc.2_Intron|ARHGEF1_uc002osd.2_Intron|ARHGEF1_uc002ose.2_Intron	NM_004706	NP_004697			Rho guanine nucleotide exchange factor 1 isoform						cell proliferation|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(3)|large_intestine(1)	4		Renal(1328;0.000518)|Hepatocellular(1079;0.0046)|Medulloblastoma(540;0.0425)		Epithelial(262;5.89e-46)|GBM - Glioblastoma multiforme(1328;2.49e-12)|STAD - Stomach adenocarcinoma(1328;0.00644)														---	---	---	---
POU2F2	5452	broad.mit.edu	37	19	42596301	42596302	+	Frame_Shift_Ins	INS	-	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42596301_42596302insG	uc002osp.2	-	13	1386_1387	c.1319_1320insC	c.(1318-1320)CCGfs	p.P440fs	POU2F2_uc002osn.2_Frame_Shift_Ins_p.P424fs|POU2F2_uc002oso.2_Frame_Shift_Ins_p.P213fs|POU2F2_uc002osq.2_Intron|POU2F2_uc002osr.1_Frame_Shift_Ins_p.P440fs	NM_002698	NP_002689	P09086	PO2F2_HUMAN	POU domain, class 2, transcription factor 2	440					humoral immune response|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2		Prostate(69;0.059)																---	---	---	---
PSG1	5669	broad.mit.edu	37	19	43380874	43380874	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:43380874delT	uc002ovb.2	-						PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG1_uc002oun.2_Intron|PSG1_uc002our.1_Intron|PSG1_uc010eio.1_Intron|PSG1_uc002oux.1_Intron|PSG1_uc002ouy.1_Intron|PSG1_uc002ouz.1_Intron|PSG1_uc002ova.1_Intron|PSG1_uc002ovc.2_Intron|PSG1_uc002ovd.1_Intron	NM_006905	NP_008836			pregnancy specific beta-1-glycoprotein 1						female pregnancy	extracellular region				ovary(2)	2		Prostate(69;0.00682)																---	---	---	---
PSG6	5675	broad.mit.edu	37	19	43460948	43460948	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:43460948delA	uc002ovh.1	-						PSG11_uc002ouw.2_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron					SubName: Full=Putative uncharacterized protein PSG6;						female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)																---	---	---	---
KCNN4	3783	broad.mit.edu	37	19	44280870	44280870	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:44280870delT	uc002oxl.2	-						KCNN4_uc010eiz.2_5'Flank|KCNN4_uc010eja.1_Intron	NM_002250	NP_002241			intermediate conductance calcium-activated						defense response	voltage-gated potassium channel complex	calcium-activated potassium channel activity|calmodulin binding			ovary(2)	2		Prostate(69;0.0352)			Clotrimazole(DB00257)|Halothane(DB01159)|Quinine(DB00468)													---	---	---	---
ZNF45	7596	broad.mit.edu	37	19	44423307	44423307	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:44423307delA	uc002oxu.1	-						ZNF45_uc002oxw.1_Intron|ZNF45_uc002oxv.1_Intron	NM_003425	NP_003416			zinc finger protein 45						multicellular organismal development	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1																		---	---	---	---
GIPR	2696	broad.mit.edu	37	19	46177864	46177864	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:46177864delA	uc002pcu.1	+						GIPR_uc002pct.1_Intron|GIPR_uc010xxp.1_Intron|GIPR_uc010xxq.1_Intron|MIR642_hsa-mir-642|MI0003657_5'Flank	NM_000164	NP_000155			gastric inhibitory polypeptide receptor						generation of precursor metabolites and energy|response to nutrient	integral to membrane|plasma membrane				skin(1)	1		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0056)|GBM - Glioblastoma multiforme(486;0.0832)|Epithelial(262;0.199)														---	---	---	---
GRLF1	2909	broad.mit.edu	37	19	47424841	47424841	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:47424841delC	uc010ekv.2	+	1	2909	c.2909delC	c.(2908-2910)TCCfs	p.S970fs		NM_004491	NP_004482	Q9NRY4	RHG35_HUMAN	glucocorticoid receptor DNA binding factor 1	970					axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity			central_nervous_system(1)	1		all_cancers(25;1.51e-09)|all_epithelial(76;1.87e-07)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|Ovarian(192;0.0129)|all_neural(266;0.026)|Breast(70;0.077)		all cancers(93;2.03e-05)|OV - Ovarian serous cystadenocarcinoma(262;2.57e-05)|Epithelial(262;0.00135)|GBM - Glioblastoma multiforme(486;0.0289)														---	---	---	---
GLTSCR1	29998	broad.mit.edu	37	19	48197891	48197891	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:48197891delC	uc002phh.3	+	8	2997	c.2803delC	c.(2803-2805)CCCfs	p.P935fs	GLTSCR1_uc002phi.3_Frame_Shift_Del_p.P693fs	NM_015711	NP_056526	Q9NZM4	GSCR1_HUMAN	glioma tumor suppressor candidate region gene 1	935	Poly-Pro.						protein binding			pancreas(3)	3		all_cancers(25;1.8e-07)|all_lung(116;5.73e-06)|Lung NSC(112;9.69e-06)|all_epithelial(76;2.42e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		all cancers(93;0.000358)|OV - Ovarian serous cystadenocarcinoma(262;0.000576)|Epithelial(262;0.0212)|GBM - Glioblastoma multiforme(486;0.0355)														---	---	---	---
GLTSCR1	29998	broad.mit.edu	37	19	48201844	48201844	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:48201844delC	uc002phh.3	+						GLTSCR1_uc002phi.3_Intron	NM_015711	NP_056526			glioma tumor suppressor candidate region gene 1								protein binding			pancreas(3)	3		all_cancers(25;1.8e-07)|all_lung(116;5.73e-06)|Lung NSC(112;9.69e-06)|all_epithelial(76;2.42e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		all cancers(93;0.000358)|OV - Ovarian serous cystadenocarcinoma(262;0.000576)|Epithelial(262;0.0212)|GBM - Glioblastoma multiforme(486;0.0355)												OREG0025594	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
PLA2G4C	8605	broad.mit.edu	37	19	48607758	48607758	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:48607758delA	uc002phx.2	-						PLA2G4C_uc002phw.2_Intron|PLA2G4C_uc010elr.2_Intron|PLA2G4C_uc010xzd.1_Intron|PLA2G4C_uc002phy.3_Intron	NM_003706	NP_003697			phospholipase A2, group IVC isoform 1 precursor						arachidonic acid metabolic process|glycerophospholipid catabolic process|inflammatory response|intracellular signal transduction|parturition	cytosol|membrane	calcium-independent phospholipase A2 activity|phospholipid binding			ovary(1)|skin(1)	2		all_cancers(25;2.84e-05)|all_lung(116;4.62e-05)|Lung NSC(112;7.61e-05)|all_epithelial(76;0.000192)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;8.09e-05)|all cancers(93;0.000517)|Epithelial(262;0.0135)|GBM - Glioblastoma multiforme(486;0.0717)														---	---	---	---
PLEKHA4	57664	broad.mit.edu	37	19	49355300	49355300	+	Intron	DEL	A	-	-	rs148248855	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49355300delA	uc002pkx.2	-						PLEKHA4_uc002pkw.1_Intron|PLEKHA4_uc010eml.2_Intron	NM_020904	NP_065955			pleckstrin homology domain containing family A							cytoplasm|membrane	1-phosphatidylinositol binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;0.000108)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00027)|all cancers(93;0.00084)|GBM - Glioblastoma multiforme(486;0.0244)|Epithelial(262;0.0364)														---	---	---	---
PRR12	57479	broad.mit.edu	37	19	50123757	50123758	+	Intron	DEL	GG	-	-	rs150809851	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50123757_50123758delGG	uc002poo.3	+							NM_020719	NP_065770			proline rich 12								DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)														---	---	---	---
MED25	81857	broad.mit.edu	37	19	50333113	50333113	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50333113delC	uc002ppw.1	+	6	649	c.596delC	c.(595-597)GCCfs	p.A199fs	MED25_uc010ybe.1_Intron|MED25_uc002ppx.1_5'UTR	NM_030973	NP_112235	Q71SY5	MED25_HUMAN	mediator complex subunit 25	199	Interaction with the Mediator complex.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm				ovary(1)	1		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00822)|GBM - Glioblastoma multiforme(134;0.0122)														---	---	---	---
NR1H2	7376	broad.mit.edu	37	19	50880753	50880753	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50880753delA	uc010enw.2	+						NR1H2_uc002prv.3_Intron|NR1H2_uc002prz.3_Intron|NR1H2_uc002psa.3_Intron	NM_007121	NP_009052			nuclear receptor subfamily 1, group H, member 2						negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of pinocytosis|negative regulation of transcription, DNA-dependent|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)														---	---	---	---
POLD1	5424	broad.mit.edu	37	19	50911948	50911948	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50911948delT	uc002psb.3	+						POLD1_uc002psc.3_Intron|POLD1_uc010enx.2_Intron|POLD1_uc010eny.2_Intron	NM_002691	NP_002682			DNA-directed DNA polymerase delta 1						base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|response to UV|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm|nucleotide-excision repair complex	3'-5'-exodeoxyribonuclease activity|chromatin binding|DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding|protein binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2		all_neural(266;0.0571)		OV - Ovarian serous cystadenocarcinoma(262;0.00794)|GBM - Glioblastoma multiforme(134;0.0195)									DNA_polymerases_(catalytic_subunits)					---	---	---	---
SHANK1	50944	broad.mit.edu	37	19	51169796	51169796	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:51169796delG	uc002psx.1	-	22	5440	c.5421delC	c.(5419-5421)CCCfs	p.P1807fs	SHANK1_uc002psw.1_Frame_Shift_Del_p.P1191fs	NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	1807					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)														---	---	---	---
SIGLEC10	89790	broad.mit.edu	37	19	51914229	51914230	+	3'UTR	DEL	AG	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:51914229_51914230delAG	uc002pwo.2	-	11					SIGLEC10_uc002pwp.2_3'UTR|SIGLEC10_uc002pwq.2_3'UTR|SIGLEC10_uc002pwr.2_3'UTR|SIGLEC10_uc010ycy.1_3'UTR|SIGLEC10_uc010ycz.1_3'UTR|SIGLEC10_uc010eow.2_3'UTR	NM_033130	NP_149121			sialic acid binding Ig-like lectin 10 precursor						cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)														---	---	---	---
ZNF613	79898	broad.mit.edu	37	19	52443377	52443377	+	Intron	DEL	A	-	-	rs67569758	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:52443377delA	uc002pxz.1	+						ZNF613_uc002pya.1_Intron	NM_001031721	NP_001026891			zinc finger protein 613 isoform 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.0183)														---	---	---	---
ZNF616	90317	broad.mit.edu	37	19	52620301	52620301	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:52620301delT	uc002pym.2	-						ZNF616_uc002pyn.2_Intron	NM_178523	NP_848618			zinc finger protein 616						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)														---	---	---	---
ZNF766	90321	broad.mit.edu	37	19	52786701	52786702	+	Intron	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:52786701_52786702delTT	uc002pyr.1	+						ZNF766_uc002pys.1_Intron|ZNF766_uc002pyt.1_Intron	NM_001010851	NP_001010851			zinc finger protein 766						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00236)|OV - Ovarian serous cystadenocarcinoma(262;0.00871)														---	---	---	---
ZNF880	400713	broad.mit.edu	37	19	52877717	52877717	+	Intron	DEL	T	-	-	rs77187934		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:52877717delT	uc002pzc.2	+						ZNF880_uc002pzb.3_Intron	NM_001145434	NP_001138906			zinc finger protein LOC400713						regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0																		---	---	---	---
ZNF160	90338	broad.mit.edu	37	19	53577206	53577206	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:53577206delT	uc010eqk.2	-						ZNF160_uc002qaq.3_Intron|ZNF160_uc002qar.3_Intron|ZNF160_uc002qas.3_Intron	NM_001102603	NP_001096073			zinc finger protein 160						hemopoiesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(134;0.02)														---	---	---	---
MBOAT7	79143	broad.mit.edu	37	19	54692246	54692246	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54692246delC	uc002qdq.2	-						MBOAT7_uc010erg.2_5'Flank|MBOAT7_uc010yem.1_5'Flank|MBOAT7_uc002qdr.2_Intron|MBOAT7_uc002qds.2_Intron|MBOAT7_uc010yen.1_Intron|MBOAT7_uc002qdt.3_Intron|TSEN34_uc010yeo.1_5'Flank|TSEN34_uc002qdu.2_5'Flank|TSEN34_uc002qdv.2_5'Flank|TSEN34_uc002qdw.2_5'Flank	NM_024298	NP_077274			membrane bound O-acyltransferase domain						phospholipid biosynthetic process	integral to membrane	acyltransferase activity				0	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)																	---	---	---	---
KIR2DL1	3802	broad.mit.edu	37	19	55286500	55286501	+	Intron	DEL	GA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55286500_55286501delGA	uc002qhb.1	+						KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR2DL3_uc010erw.1_Intron|KIR2DL1_uc002qgz.1_Intron|KIR2DL3_uc002qha.1_Intron|KIR3DP1_uc010yfi.1_Intron|KIR2DL1_uc010erz.1_Intron	NM_014218	NP_055033			killer cell immunoglobulin-like receptor, two						immune response|natural killer cell inhibitory signaling pathway	integral to plasma membrane	protein binding|receptor activity				0				GBM - Glioblastoma multiforme(193;0.0192)														---	---	---	---
U2AF2	11338	broad.mit.edu	37	19	56173837	56173837	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:56173837delC	uc002qlu.2	+						U2AF2_uc002qlt.2_Intron	NM_007279	NP_009210			U2 (RNU2) small nuclear RNA auxiliary factor 2						mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	nucleoplasm|spliceosomal complex	enzyme binding|nucleotide binding|RNA binding			ovary(1)	1		Colorectal(82;0.00244)|Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)														---	---	---	---
ZIM3	114026	broad.mit.edu	37	19	57646387	57646387	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:57646387delT	uc002qnz.1	-	5	1704	c.1318delA	c.(1318-1320)ACCfs	p.T440fs		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	440	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)														---	---	---	---
DUXA	503835	broad.mit.edu	37	19	57670785	57670785	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:57670785delT	uc002qoa.1	-							NM_001012729	NP_001012747			double homeobox A							nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0123)														---	---	---	---
Unknown	0	broad.mit.edu	37	19	58727943	58727943	+	IGR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58727943delA								ZNF274 (3016 upstream) : ZNF544 (12127 downstream)																																			---	---	---	---
MZF1	7593	broad.mit.edu	37	19	59073814	59073816	+	In_Frame_Del	DEL	GAG	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:59073814_59073816delGAG	uc002qto.2	-	6	2389_2391	c.1828_1830delCTC	c.(1828-1830)CTCdel	p.L610del	LOC100131691_uc002qtm.2_Intron|MZF1_uc002qtn.2_In_Frame_Del_p.L610del	NM_198055	NP_932172	P28698	MZF1_HUMAN	zinc finger protein 42 isoform 2	610	C2H2-type 9.				viral reproduction	nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0443)|all cancers(4;7.92e-14)|Epithelial(4;5.57e-11)|OV - Ovarian serous cystadenocarcinoma(4;1.13e-09)|GBM - Glioblastoma multiforme(193;0.0108)|Lung(386;0.182)														---	---	---	---
Unknown	0	broad.mit.edu	37	20	2056532	2056532	+	IGR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:2056532delA								PDYN (81829 upstream) : STK35 (25996 downstream)																																			---	---	---	---
SLC4A11	83959	broad.mit.edu	37	20	3215425	3215425	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:3215425delA	uc002wig.2	-	2	300	c.252delT	c.(250-252)TTTfs	p.F84fs	SLC4A11_uc010zqe.1_Frame_Shift_Del_p.F111fs|SLC4A11_uc002wih.2_RNA|SLC4A11_uc010zqf.1_Frame_Shift_Del_p.F68fs	NM_032034	NP_114423	Q8NBS3	S4A11_HUMAN	solute carrier family 4 member 11	84	Cytoplasmic (Potential).				cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			ovary(1)	1																		---	---	---	---
C20orf194	25943	broad.mit.edu	37	20	3278997	3278997	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:3278997delT	uc002wii.2	-						C20orf194_uc002wij.3_Intron|C20orf194_uc002wik.2_Intron	NM_001009984	NP_001009984			hypothetical protein LOC25943												0																		---	---	---	---
RNF24	11237	broad.mit.edu	37	20	3928694	3928695	+	Intron	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:3928694_3928695delAA	uc002wkh.2	-						RNF24_uc002wki.2_Intron|RNF24_uc002wkj.2_Intron	NM_007219	NP_009150			ring finger protein 24 isoform 1							Golgi membrane|integral to membrane	zinc ion binding				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	20	5272768	5272768	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:5272768delT								CDS2 (100781 upstream) : PROKR2 (9919 downstream)																																			---	---	---	---
SEL1L2	80343	broad.mit.edu	37	20	13936616	13936616	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:13936616delA	uc010gcf.2	-						SEL1L2_uc002woq.3_Intron|SEL1L2_uc010zrl.1_Intron|SEL1L2_uc002wor.2_Intron	NM_025229	NP_079505			sel-1 suppressor of lin-12-like 2 precursor							integral to membrane	binding			ovary(2)	2																		---	---	---	---
MACROD2	140733	broad.mit.edu	37	20	15948034	15948034	+	Intron	DEL	A	-	-	rs6080063	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:15948034delA	uc002wou.2	+						MACROD2_uc002wot.2_Intron|MACROD2_uc002woz.2_Intron|MACROD2_uc002wpb.2_Intron	NM_080676	NP_542407			MACRO domain containing 2 isoform 1												0		all_neural(2;0.0381)|Acute lymphoblastic leukemia(2;0.175)																---	---	---	---
SLC24A3	57419	broad.mit.edu	37	20	19646521	19646521	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:19646521delA	uc002wrl.2	+	8	898	c.701delA	c.(700-702)GAAfs	p.E234fs		NM_020689	NP_065740	Q9HC58	NCKX3_HUMAN	solute carrier family 24	234	Extracellular (Potential).					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	20	19804033	19804034	+	IGR	DEL	TT	-	-	rs57730958		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:19804033_19804034delTT								SLC24A3 (100493 upstream) : RIN2 (66176 downstream)																																			---	---	---	---
XRN2	22803	broad.mit.edu	37	20	21338218	21338218	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:21338218delT	uc002wsf.1	+						XRN2_uc002wsg.1_Intron|XRN2_uc010zsk.1_Intron	NM_012255	NP_036387			5'-3' exoribonuclease 2						cell growth|DNA catabolic process, exonucleolytic|mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|spermatogenesis|transcription termination, DNA-dependent	nucleolus	5'-3' exoribonuclease activity|nucleic acid binding|protein binding|zinc ion binding			skin(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	20	29930733	29930733	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:29930733delT								DEFB116 (34345 upstream) : DEFB118 (25695 downstream)																																			---	---	---	---
TTLL9	164395	broad.mit.edu	37	20	30525059	30525059	+	Intron	DEL	A	-	-	rs6061041	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:30525059delA	uc010gdx.1	+						TTLL9_uc002wwy.1_Intron|TTLL9_uc002wwz.1_Intron|TTLL9_uc002wxa.1_Intron|TTLL9_uc002wxb.1_Intron|TTLL9_uc010zto.1_Intron|TTLL9_uc002wxc.2_Intron|TTLL9_uc010ztp.1_Intron|TTLL9_uc010ztq.1_Intron	NM_001008409	NP_001008409			tubulin tyrosine ligase-like family, member 9						protein modification process	cilium|microtubule|microtubule basal body	ATP binding|tubulin-tyrosine ligase activity			ovary(2)	2			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)															---	---	---	---
PLAGL2	5326	broad.mit.edu	37	20	30784139	30784139	+	3'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:30784139delT	uc002wxn.2	-	3						NM_002657	NP_002648			pleiomorphic adenoma gene-like 2							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)															---	---	---	---
GDF5	8200	broad.mit.edu	37	20	33961902	33961902	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:33961902delA	uc010gfc.1	-						UQCC_uc010zuy.1_Intron|UQCC_uc002xcd.2_Intron|UQCC_uc010zuz.1_Intron|UQCC_uc010zva.1_Intron|UQCC_uc002xce.2_Intron|UQCC_uc002xcg.2_Intron|UQCC_uc010gfb.2_Intron|UQCC_uc010zvb.1_Intron|UQCC_uc002xcf.2_Intron|UQCC_uc002xci.1_Intron|UQCC_uc010gfd.1_Intron	NM_000557	NP_000548			growth differentiation factor 5 preproprotein						cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity				0	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)															---	---	---	---
DSN1	79980	broad.mit.edu	37	20	35395406	35395407	+	Intron	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:35395406_35395407delAA	uc010gfr.2	-						DSN1_uc002xfz.2_Intron|DSN1_uc002xfy.3_Intron|DSN1_uc002xga.2_Intron|DSN1_uc010zvs.1_Intron|DSN1_uc002xgc.2_Intron|DSN1_uc002xgb.2_Intron	NM_001145316	NP_001138788			DSN1, MIND kinetochore complex component,						cell division|chromosome segregation|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding			ovary(2)	2		Myeloproliferative disorder(115;0.00874)																---	---	---	---
DSN1	79980	broad.mit.edu	37	20	35396636	35396636	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:35396636delA	uc010gfr.2	-						DSN1_uc002xfz.2_Intron|DSN1_uc002xfy.3_Intron|DSN1_uc002xga.2_Intron|DSN1_uc010zvs.1_Intron|DSN1_uc002xgc.2_Intron|DSN1_uc002xgb.2_Intron	NM_001145316	NP_001138788			DSN1, MIND kinetochore complex component,						cell division|chromosome segregation|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding			ovary(2)	2		Myeloproliferative disorder(115;0.00874)																---	---	---	---
RALGAPB	57148	broad.mit.edu	37	20	37169993	37169993	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:37169993delT	uc002xiw.2	+						RALGAPB_uc002xix.2_Intron|RALGAPB_uc002xiy.1_Intron|RALGAPB_uc002xiz.2_Intron|RALGAPB_uc002xja.1_Intron	NM_020336	NP_065069			Ral GTPase activating protein, beta subunit						activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			pancreas(1)|skin(1)	2																		---	---	---	---
STK4	6789	broad.mit.edu	37	20	43607423	43607423	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:43607423delT	uc002xnb.2	+						STK4_uc010ggx.2_Intron|STK4_uc010ggy.2_Intron|STK4_uc010ggw.1_Intron	NM_006282	NP_006273			serine/threonine kinase 4						apoptosis|cell morphogenesis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of apoptosis|protein autophosphorylation	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein homodimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity|transcription factor binding			ovary(1)|skin(1)	2		Myeloproliferative disorder(115;0.0122)																---	---	---	---
NCOA3	8202	broad.mit.edu	37	20	46251243	46251243	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:46251243delT	uc002xtk.2	+						NCOA3_uc010ght.1_Intron|NCOA3_uc002xtl.2_Intron|NCOA3_uc002xtm.2_Intron|NCOA3_uc002xtn.2_Intron	NM_181659	NP_858045			nuclear receptor coactivator 3 isoform a						androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5																		---	---	---	---
NCOA3	8202	broad.mit.edu	37	20	46281062	46281062	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:46281062delA	uc002xtk.2	+						NCOA3_uc002xtl.2_Intron|NCOA3_uc002xtm.2_Intron|NCOA3_uc002xtn.2_Intron|NCOA3_uc010zyc.1_Intron	NM_181659	NP_858045			nuclear receptor coactivator 3 isoform a						androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5																		---	---	---	---
ADNP	23394	broad.mit.edu	37	20	49510942	49510943	+	Frame_Shift_Ins	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:49510942_49510943insT	uc002xvt.1	-	5	653_654	c.308_309insA	c.(307-309)AATfs	p.N103fs	ADNP_uc002xvu.1_Frame_Shift_Ins_p.N103fs	NM_015339	NP_056154	Q9H2P0	ADNP_HUMAN	activity-dependent neuroprotector	103						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2																		---	---	---	---
PHACTR3	116154	broad.mit.edu	37	20	58416343	58416343	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:58416343delT	uc002yau.2	+						PHACTR3_uc002yat.2_Intron|PHACTR3_uc010zzw.1_Intron|PHACTR3_uc002yav.2_Intron|PHACTR3_uc002yaw.2_Intron|PHACTR3_uc002yax.2_Intron|PHACTR3_uc002yay.2_Intron	NM_080672	NP_542403			phosphatase and actin regulator 3 isoform 1							nuclear matrix	actin binding|protein phosphatase inhibitor activity			ovary(2)|pancreas(1)	3	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)															---	---	---	---
C20orf177	63939	broad.mit.edu	37	20	58518896	58518896	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:58518896delA	uc002yba.2	+						C20orf177_uc010zzx.1_Intron|C20orf177_uc002ybc.2_Intron	NM_022106	NP_071389			hypothetical protein LOC63939											ovary(2)|breast(1)	3	all_lung(29;0.00693)		BRCA - Breast invasive adenocarcinoma(7;1.22e-08)															---	---	---	---
PRPF6	24148	broad.mit.edu	37	20	62658153	62658153	+	Intron	DEL	A	-	-	rs66797782		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:62658153delA	uc002yho.2	+						PRPF6_uc002yhp.2_Intron	NM_012469	NP_036601			PRP6 pre-mRNA processing factor 6 homolog						assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			ovary(2)	2	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)																	---	---	---	---
LIPI	149998	broad.mit.edu	37	21	15537722	15537722	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:15537722delA	uc002yjm.2	-						LIPI_uc010gkw.1_Intron	NM_198996	NP_945347			lipase, member I						lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			ovary(2)	2				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)														---	---	---	---
RBM11	54033	broad.mit.edu	37	21	15593370	15593370	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:15593370delA	uc002yjo.3	+						RBM11_uc002yjn.3_Intron|RBM11_uc002yjp.3_Intron	NM_144770	NP_658983			RNA binding motif protein 11								nucleotide binding|RNA binding				0				Epithelial(23;0.000314)|COAD - Colon adenocarcinoma(22;0.00242)|Colorectal(24;0.0129)|Lung(58;0.141)														---	---	---	---
USP25	29761	broad.mit.edu	37	21	17250089	17250089	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:17250089delT	uc002yjy.1	+						USP25_uc011aby.1_Intron|USP25_uc002yjz.1_Intron|USP25_uc010gla.1_Intron	NM_013396	NP_037528			ubiquitin specific peptidase 25						protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)|liver(2)	5				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)														---	---	---	---
ADAMTS5	11096	broad.mit.edu	37	21	28304600	28304600	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:28304600delT	uc002ymg.2	-							NM_007038	NP_008969			ADAM metallopeptidase with thrombospondin type 1						proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4																		---	---	---	---
RNF160	26046	broad.mit.edu	37	21	30341545	30341545	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:30341545delA	uc002ymr.2	-						RNF160_uc010gll.1_Intron	NM_015565	NP_056380			zinc finger protein 294								ligase activity|zinc ion binding				0																		---	---	---	---
USP16	10600	broad.mit.edu	37	21	30415629	30415629	+	Intron	DEL	A	-	-	rs2832157	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:30415629delA	uc002ymy.2	+						USP16_uc002ymx.2_Intron|USP16_uc002ymw.2_Intron|USP16_uc011acm.1_Intron|USP16_uc011acn.1_Intron|USP16_uc011aco.1_Intron	NM_006447	NP_006438			ubiquitin specific protease 16 isoform a						cell division|histone deubiquitination|mitosis|positive regulation of transcription, DNA-dependent|protein homotetramerization|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|histone binding|transcription coactivator activity|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(2)|breast(1)|pancreas(1)	4																		---	---	---	---
USP16	10600	broad.mit.edu	37	21	30426572	30426572	+	3'UTR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:30426572delA	uc002ymy.2	+	18					USP16_uc002ymx.2_3'UTR|USP16_uc002ymw.2_3'UTR|USP16_uc011acm.1_3'UTR|USP16_uc011acn.1_3'UTR|USP16_uc011aco.1_3'UTR	NM_006447	NP_006438			ubiquitin specific protease 16 isoform a						cell division|histone deubiquitination|mitosis|positive regulation of transcription, DNA-dependent|protein homotetramerization|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|histone binding|transcription coactivator activity|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(2)|breast(1)|pancreas(1)	4																		---	---	---	---
CCT8	10694	broad.mit.edu	37	21	30442663	30442664	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:30442663_30442664insA	uc002ynb.2	-						CCT8_uc011acp.1_Intron|CCT8_uc002yna.2_Intron|CCT8_uc002ync.2_Intron|CCT8_uc010glm.2_Intron|CCT8_uc011acq.1_Intron	NM_006585	NP_006576			chaperonin containing TCP1, subunit 8 (theta)						'de novo' posttranslational protein folding	aggresome|cytosol|intermediate filament cytoskeleton|microtubule organizing center	ATP binding|ATPase activity, coupled|unfolded protein binding				0																		---	---	---	---
HUNK	30811	broad.mit.edu	37	21	33346635	33346635	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:33346635delA	uc002yph.2	+							NM_014586	NP_055401			hormonally upregulated Neu-associated kinase						multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			stomach(1)|skin(1)	2																		---	---	---	---
GCFC1	94104	broad.mit.edu	37	21	34116927	34116927	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:34116927delA	uc002yqn.2	-						GCFC1_uc002yql.2_Intron|GCFC1_uc002yqm.2_Intron|GCFC1_uc002yqo.2_Intron|GCFC1_uc002yqp.2_Intron	NM_016631	NP_057715			GC-rich sequence DNA-binding factor candidate							cytosol|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2																		---	---	---	---
GCFC1	94104	broad.mit.edu	37	21	34134360	34134360	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:34134360delA	uc002yqn.2	-						GCFC1_uc002yqo.2_Intron|GCFC1_uc002yqp.2_Intron|GCFC1_uc002yqr.2_Intron	NM_016631	NP_057715			GC-rich sequence DNA-binding factor candidate							cytosol|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2																		---	---	---	---
IFNAR1	3454	broad.mit.edu	37	21	34715563	34715563	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:34715563delT	uc002yrn.2	+						IFNAR1_uc011adv.1_Intron	NM_000629	NP_000620			interferon-alpha receptor 1 precursor						JAK-STAT cascade|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	integral to plasma membrane	type I interferon receptor activity			central_nervous_system(1)|skin(1)	2					Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Interferon alfa-n3(DB00018)|Interferon alfacon-1(DB00069)|Interferon beta-1b(DB00068)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)													---	---	---	---
GART	2618	broad.mit.edu	37	21	34903299	34903299	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:34903299delT	uc002yrx.2	-						GART_uc002yrz.2_Intron|GART_uc010gmd.2_Intron|GART_uc002yry.2_Intron|GART_uc002ysa.2_Intron	NM_000819	NP_000810			phosphoribosylglycinamide formyltransferase,						'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding			ovary(1)	1					Pemetrexed(DB00642)													---	---	---	---
GART	2618	broad.mit.edu	37	21	34906683	34906683	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:34906683delT	uc002yrx.2	-						GART_uc002yrz.2_Intron|GART_uc010gmd.2_Intron|GART_uc002yry.2_Intron|GART_uc002ysa.2_Intron	NM_000819	NP_000810			phosphoribosylglycinamide formyltransferase,						'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding			ovary(1)	1					Pemetrexed(DB00642)													---	---	---	---
DONSON	29980	broad.mit.edu	37	21	34953532	34953532	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:34953532delT	uc002ysk.2	-						DONSON_uc002ysi.1_Intron|DONSON_uc002ysj.2_Intron|DONSON_uc002ysl.2_Intron|DONSON_uc010gme.2_Intron|DONSON_uc002ysm.2_Intron	NM_017613	NP_060083			downstream neighbor of SON						multicellular organismal development	nucleus				ovary(1)|central_nervous_system(1)	2																		---	---	---	---
DONSON	29980	broad.mit.edu	37	21	34958633	34958633	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:34958633delA	uc002ysk.2	-						DONSON_uc002ysn.1_Intron|DONSON_uc002ysi.1_5'Flank|DONSON_uc002ysj.2_Intron|DONSON_uc002ysl.2_Intron|DONSON_uc010gme.2_Intron|DONSON_uc002ysm.2_Intron	NM_017613	NP_060083			downstream neighbor of SON						multicellular organismal development	nucleus				ovary(1)|central_nervous_system(1)	2																OREG0003565	type=REGULATORY REGION|Gene=DONSON|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	---	---	---	---
ITSN1	6453	broad.mit.edu	37	21	35138206	35138206	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:35138206delA	uc002yta.1	+	10	1084	c.816delA	c.(814-816)GGAfs	p.G272fs	DONSON_uc002ysn.1_Intron|ITSN1_uc002yth.3_RNA|ITSN1_uc002ysz.2_Frame_Shift_Del_p.G272fs|ITSN1_uc010gmg.2_Frame_Shift_Del_p.G235fs|ITSN1_uc010gmh.2_RNA|ITSN1_uc002ysw.2_Frame_Shift_Del_p.G272fs|ITSN1_uc010gmi.2_Frame_Shift_Del_p.G235fs|ITSN1_uc010gmj.2_Frame_Shift_Del_p.G156fs|ITSN1_uc002ysy.2_Frame_Shift_Del_p.G272fs|ITSN1_uc002ysx.2_Frame_Shift_Del_p.G235fs|ITSN1_uc002ytb.1_Frame_Shift_Del_p.G272fs|ITSN1_uc002ytc.1_Frame_Shift_Del_p.G272fs|ITSN1_uc002ytd.2_RNA|ITSN1_uc010gmk.2_Frame_Shift_Del_p.G235fs|ITSN1_uc010gml.2_RNA|ITSN1_uc002ytj.2_Frame_Shift_Del_p.G272fs|ITSN1_uc010gmm.1_RNA|ITSN1_uc002yte.2_Frame_Shift_Del_p.G206fs	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	272	EF-hand 2.|EH 2.|2 (Potential).				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4																		---	---	---	---
RCAN1	1827	broad.mit.edu	37	21	35899182	35899182	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:35899182delA	uc002yue.2	-						RCAN1_uc002yuc.2_Intron|RCAN1_uc002yud.2_Intron|RCAN1_uc002yub.2_5'UTR|RCAN1_uc011adx.1_5'UTR	NM_004414	NP_004405			calcipressin 1 isoform a						blood circulation|calcium-mediated signaling|central nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0																		---	---	---	---
MORC3	23515	broad.mit.edu	37	21	37710947	37710947	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:37710947delA	uc002yvi.2	+							NM_015358	NP_056173			MORC family CW-type zinc finger 3						cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			ovary(2)	2																		---	---	---	---
TTC3	7267	broad.mit.edu	37	21	38462768	38462770	+	Intron	DEL	TTT	-	-	rs138757481	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:38462768_38462770delTTT	uc002yvz.2	+						TTC3_uc011aee.1_Intron|TTC3_uc002ywa.2_Intron|TTC3_uc002ywb.2_Intron|TTC3_uc010gnf.2_Intron|TTC3_uc011aed.1_Intron|TTC3_uc010gne.1_Intron	NM_001001894	NP_001001894			tetratricopeptide repeat domain 3						protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)																---	---	---	---
TTC3	7267	broad.mit.edu	37	21	38501387	38501387	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:38501387delT	uc002yvz.2	+						TTC3_uc011aee.1_Intron|TTC3_uc002ywa.2_Intron|TTC3_uc002ywb.2_Intron|TTC3_uc010gnf.2_Intron|TTC3_uc002ywc.2_Intron|TTC3_uc011aed.1_Intron|TTC3_uc010gne.1_Intron	NM_001001894	NP_001001894			tetratricopeptide repeat domain 3						protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)																---	---	---	---
TTC3	7267	broad.mit.edu	37	21	38555250	38555250	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:38555250delA	uc002yvz.2	+						TTC3_uc002ywa.2_Intron|TTC3_uc002ywb.2_Intron|TTC3_uc010gnf.2_Intron|TTC3_uc002ywc.2_Intron|TTC3_uc002ywd.1_Intron	NM_001001894	NP_001001894			tetratricopeptide repeat domain 3						protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)																---	---	---	---
DSCAM	1826	broad.mit.edu	37	21	41741258	41741260	+	Intron	DEL	TTC	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:41741258_41741260delTTC	uc002yyq.1	-						DSCAM_uc002yyr.1_Intron	NM_001389	NP_001380			Down syndrome cell adhesion molecule isoform						cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)																---	---	---	---
PRDM15	63977	broad.mit.edu	37	21	43281651	43281652	+	Intron	INS	-	G	G	rs7280316	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:43281651_43281652insG	uc002yzq.1	-						PRDM15_uc002yzo.2_Intron|PRDM15_uc002yzp.2_Intron|PRDM15_uc002yzr.1_Intron	NM_022115	NP_071398			PR domain containing 15 isoform 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
UMODL1	89766	broad.mit.edu	37	21	43541382	43541382	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:43541382delT	uc002zaf.1	+						UMODL1_uc002zad.1_Intron|UMODL1_uc002zae.1_Intron|UMODL1_uc002zag.1_Intron|UMODL1_uc002zal.1_Intron	NM_001004416	NP_001004416			uromodulin-like 1 isoform 1 precursor							cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3																		---	---	---	---
COL18A1	80781	broad.mit.edu	37	21	46896416	46896417	+	Intron	DEL	GT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:46896416_46896417delGT	uc011afs.1	+						COL18A1_uc002zhg.2_Intron|COL18A1_uc002zhi.2_Intron	NM_130444	NP_569711			alpha 1 type XVIII collagen isoform 3 precursor						cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			central_nervous_system(1)	1				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)														---	---	---	---
Unknown	0	broad.mit.edu	37	22	16915281	16915281	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:16915281delT								OR11H1 (465477 upstream) : CCT8L2 (156367 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	22	17054210	17054211	+	IGR	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:17054210_17054211insA								OR11H1 (604406 upstream) : CCT8L2 (17437 downstream)																																			---	---	---	---
LZTR1	8216	broad.mit.edu	37	22	21348214	21348216	+	In_Frame_Del	DEL	AGG	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:21348214_21348216delAGG	uc002zto.2	+	13	1458_1460	c.1355_1357delAGG	c.(1354-1359)AAGGAG>AAG	p.E454del	LZTR1_uc002ztn.2_In_Frame_Del_p.E413del|LZTR1_uc011ahy.1_In_Frame_Del_p.E435del|LZTR1_uc010gsr.1_In_Frame_Del_p.E325del|LZTR1_uc002ztp.2_5'Flank	NM_006767	NP_006758	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	454	BTB 1.				anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			ovary(2)|lung(2)	4	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)															---	---	---	---
MAPK1	5594	broad.mit.edu	37	22	22153427	22153427	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:22153427delA	uc002zvn.2	-						MAPK1_uc002zvo.2_Intron|MAPK1_uc010gtk.1_Intron	NM_002745	NP_002736			mitogen-activated protein kinase 1						activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|induction of apoptosis|innate immune response|insulin receptor signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleoplasm	ATP binding|DNA binding|MAP kinase activity|phosphatase binding|RNA polymerase II carboxy-terminal domain kinase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3	Colorectal(54;0.105)	all_lung(157;3.89e-05)		READ - Rectum adenocarcinoma(21;0.0689)	Arsenic trioxide(DB01169)													---	---	---	---
PIWIL3	440822	broad.mit.edu	37	22	25115584	25115584	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:25115584delA	uc003abd.1	-						PIWIL3_uc011ajx.1_Intron|PIWIL3_uc011ajy.1_Intron|PIWIL3_uc010gut.1_Intron	NM_001008496	NP_001008496			piwi-like 3						cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			ovary(3)|central_nervous_system(1)	4																		---	---	---	---
ADRBK2	157	broad.mit.edu	37	22	26043916	26043916	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:26043916delA	uc003abx.3	+						ADRBK2_uc010gux.2_Intron|ADRBK2_uc003abw.2_Intron|ADRBK2_uc003aby.3_Intron	NM_005160	NP_005151			beta-adrenergic receptor kinase 2								ATP binding|beta-adrenergic receptor kinase activity|signal transducer activity			lung(3)|ovary(2)|stomach(1)|central_nervous_system(1)	7					Adenosine triphosphate(DB00171)													---	---	---	---
CHEK2	11200	broad.mit.edu	37	22	29115460	29115460	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:29115460delA	uc003adu.1	-	5	678	c.606delT	c.(604-606)TTTfs	p.F202fs	CHEK2_uc003ads.1_5'UTR|CHEK2_uc010gvh.1_Frame_Shift_Del_p.F111fs|CHEK2_uc010gvi.1_Frame_Shift_Del_p.F202fs|CHEK2_uc010gvj.1_Intron|CHEK2_uc003adr.1_Intron|CHEK2_uc010gvk.1_RNA|CHEK2_uc003adt.1_Frame_Shift_Del_p.F245fs|CHEK2_uc003adv.1_Frame_Shift_Del_p.F202fs|CHEK2_uc003adw.1_Frame_Shift_Del_p.F202fs|CHEK2_uc003adx.1_5'UTR|CHEK2_uc003ady.1_Frame_Shift_Del_p.F202fs|CHEK2_uc003adz.1_Frame_Shift_Del_p.F6fs	NM_007194	NP_009125	O96017	CHK2_HUMAN	protein kinase CHK2 isoform a	202					cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(17)|stomach(1)|ovary(1)|lung(1)	20								F			breast 		Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|CHEK2-associated_cancer				---	---	---	---
EMID1	129080	broad.mit.edu	37	22	29626944	29626944	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:29626944delA	uc003aen.2	+						EMID1_uc003aem.2_Intron|EMID1_uc003aeo.2_Intron|EMID1_uc003aep.2_Intron	NM_133455	NP_597712			EMI domain containing 1							collagen					0																		---	---	---	---
AP1B1	162	broad.mit.edu	37	22	29727880	29727880	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:29727880delG	uc003afj.2	-	18	2519	c.2335delC	c.(2335-2337)CTCfs	p.L779fs	AP1B1_uc003afi.2_Frame_Shift_Del_p.L772fs|AP1B1_uc003afk.2_Frame_Shift_Del_p.L772fs|AP1B1_uc003afl.2_Frame_Shift_Del_p.L752fs|AP1B1_uc003afh.2_5'UTR|AP1B1_uc011ako.1_Frame_Shift_Del_p.L332fs	NM_001127	NP_001118	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1 beta 1 subunit	779					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			ovary(1)|skin(1)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	22	29819372	29819373	+	IGR	DEL	TT	-	-	rs67350067		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:29819372_29819373delTT								AP1B1 (34803 upstream) : RFPL1S (13633 downstream)																																			---	---	---	---
MORC2	22880	broad.mit.edu	37	22	31329912	31329912	+	Intron	DEL	G	-	-	rs71740454		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:31329912delG	uc003aje.1	-							NM_014941	NP_055756			MORC family CW-type zinc finger 2								ATP binding|zinc ion binding			ovary(1)|pancreas(1)	2																		---	---	---	---
RNF185	91445	broad.mit.edu	37	22	31593111	31593111	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:31593111delA	uc003akb.2	+						RNF185_uc010gwh.2_Intron|RNF185_uc011alm.1_Intron|RNF185_uc003akc.2_Intron|RNF185_uc003ake.2_Intron	NM_152267	NP_689480			ring finger protein 185 isoform 1							integral to membrane	zinc ion binding				0																		---	---	---	---
DEPDC5	9681	broad.mit.edu	37	22	32194509	32194509	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:32194509delA	uc003als.2	+						DEPDC5_uc011als.1_Intron|DEPDC5_uc011alu.1_Intron|DEPDC5_uc011alv.1_Intron|DEPDC5_uc003alt.2_Intron|DEPDC5_uc003alr.1_Intron|DEPDC5_uc011alt.1_Intron	NM_014662	NP_055477			DEP domain containing 5 isoform 1						intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8																		---	---	---	---
Unknown	0	broad.mit.edu	37	22	32675263	32675263	+	IGR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:32675263delA								SLC5A4 (23945 upstream) : RFPL3 (75609 downstream)																																			---	---	---	---
MYH9	4627	broad.mit.edu	37	22	36691448	36691449	+	Intron	DEL	GT	-	-	rs111330544		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:36691448_36691449delGT	uc003apg.2	-							NM_002473	NP_002464			myosin, heavy polypeptide 9, non-muscle						actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11								T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				---	---	---	---
MYH9	4627	broad.mit.edu	37	22	36712840	36712840	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:36712840delA	uc003apg.2	-						MYH9_uc003aph.1_Intron	NM_002473	NP_002464			myosin, heavy polypeptide 9, non-muscle						actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11								T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				---	---	---	---
IFT27	11020	broad.mit.edu	37	22	37159188	37159188	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:37159188delC	uc003apv.1	-						IFT27_uc003apu.1_Intron|IFT27_uc003apw.1_3'UTR	NM_006860	NP_006851			RAB, member of RAS oncogene family-like 4						small GTPase mediated signal transduction	intraflagellar transport particle B|microtubule-based flagellum	GTP binding				0																		---	---	---	---
DDX17	10521	broad.mit.edu	37	22	38897211	38897211	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:38897211delT	uc003avy.3	-	2	465	c.362delA	c.(361-363)AAGfs	p.K121fs	DDX17_uc003avx.3_Frame_Shift_Del_p.K121fs|DDX17_uc011anu.1_Frame_Shift_Del_p.K34fs	NM_001098504	NP_001091974	Q92841	DDX17_HUMAN	DEAD box polypeptide 17 isoform 3	42					RNA processing	nucleus	ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity|RNA-dependent ATPase activity			skin(3)|upper_aerodigestive_tract(1)	4	Melanoma(58;0.0286)																	---	---	---	---
SMCR7L	54471	broad.mit.edu	37	22	39907838	39907839	+	Intron	DEL	CT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:39907838_39907839delCT	uc003axx.2	+						SMCR7L_uc003axw.2_Intron|SMCR7L_uc010gxz.1_Intron|SMCR7L_uc003axy.2_Intron	NM_019008	NP_061881			hypothetical protein LOC54471							integral to membrane|mitochondrion				central_nervous_system(1)	1	Melanoma(58;0.04)																	---	---	---	---
SLC25A17	10478	broad.mit.edu	37	22	41190632	41190632	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:41190632delT	uc003azc.2	-						SLC25A17_uc010gyg.2_Intron|SLC25A17_uc011aou.1_Intron|SLC25A17_uc003azd.2_Intron|SLC25A17_uc011aov.1_Intron	NM_006358	NP_006349			solute carrier family 25 (mitochondrial carrier;						fatty acid alpha-oxidation	integral to plasma membrane|mitochondrial inner membrane|peroxisomal membrane	adenine nucleotide transmembrane transporter activity|protein binding				0																		---	---	---	---
TOB2	10766	broad.mit.edu	37	22	41829914	41829914	+	3'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:41829914delT	uc003azz.1	-	2						NM_016272	NP_057356			transducer of ERBB2, 2						female gamete generation|negative regulation of cell proliferation	cytoplasm|nucleus				ovary(1)	1																		---	---	---	---
MEI1	150365	broad.mit.edu	37	22	42128780	42128784	+	Intron	DEL	ATTTT	-	-	rs11463943		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:42128780_42128784delATTTT	uc003baz.1	+						WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|MEI1_uc003bay.3_Intron|MEI1_uc011apd.1_Intron	NM_152513	NP_689726			meiosis defective 1								binding			central_nervous_system(1)|skin(1)	2																		---	---	---	---
CELSR1	9620	broad.mit.edu	37	22	46764993	46764993	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:46764993delG	uc003bhw.1	-						CELSR1_uc011arc.1_3'UTR	NM_014246	NP_055061			cadherin EGF LAG seven-pass G-type receptor 1						central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)														---	---	---	---
GRAMD4	23151	broad.mit.edu	37	22	47063886	47063886	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:47063886delG	uc003bhx.2	+						GRAMD4_uc010had.2_Intron	NM_015124	NP_055939			death-inducing-protein						apoptosis	integral to membrane|mitochondrial membrane				ovary(1)	1		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|BRCA - Breast invasive adenocarcinoma(115;0.166)														---	---	---	---
MOV10L1	54456	broad.mit.edu	37	22	50530329	50530329	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:50530329delA	uc003bjj.2	+						MOV10L1_uc003bjk.3_Intron|MOV10L1_uc011arp.1_Intron|MOV10L1_uc010han.2_Intron	NM_018995	NP_061868			MOV10-like 1 isoform 1						germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			ovary(2)|skin(1)	3		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)														---	---	---	---
CPT1B	1375	broad.mit.edu	37	22	51010856	51010856	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:51010856delT	uc003bmk.3	-						CPT1B_uc003bml.2_Intron|CPT1B_uc003bmm.2_Intron|CPT1B_uc003bmo.2_Intron|CPT1B_uc011asa.1_Intron|CPT1B_uc003bmn.2_Intron|CPT1B_uc011asb.1_Intron|CHKB-CPT1B_uc003bmp.2_Intron|uc003bmr.1_RNA	NM_001145137	NP_001138609			carnitine palmitoyltransferase 1B isoform a						carnitine shuttle|fatty acid beta-oxidation|regulation of fatty acid oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)	2		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		all cancers(3;3.56e-77)|OV - Ovarian serous cystadenocarcinoma(4;5.39e-74)|Epithelial(4;5.58e-70)|GBM - Glioblastoma multiforme(4;5.59e-08)|LUAD - Lung adenocarcinoma(64;0.0016)|Lung(4;0.00942)|BRCA - Breast invasive adenocarcinoma(115;0.207)														---	---	---	---
PPP2R3B	28227	broad.mit.edu	37	X	302445	302445	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:302445delC	uc004cpg.2	-						PPP2R3B_uc004cpf.2_5'UTR	NM_013239	NP_037371			protein phosphatase 2, regulatory subunit B'',						cell cycle arrest|protein dephosphorylation	nucleus|protein phosphatase type 2A complex	calcium ion binding|protein phosphatase type 2A regulator activity|protein serine/threonine phosphatase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)																---	---	---	---
CSF2RA	1438	broad.mit.edu	37	X	1409086	1409087	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:1409086_1409087insT	uc010nct.2	+						CSF2RA_uc011mhb.1_Intron|CSF2RA_uc004cpq.2_Intron|CSF2RA_uc004cpn.2_Intron|CSF2RA_uc004cpo.2_Intron|CSF2RA_uc010ncu.2_Intron|CSF2RA_uc011mhc.1_Intron|CSF2RA_uc004cpp.2_Intron|CSF2RA_uc010ncv.2_Intron|CSF2RA_uc004cpr.2_Intron	NM_001161529	NP_001155001			colony stimulating factor 2 receptor alpha chain							extracellular region|integral to plasma membrane	cytokine receptor activity			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)													---	---	---	---
ARSH	347527	broad.mit.edu	37	X	2942330	2942333	+	Intron	DEL	AAAA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:2942330_2942333delAAAA	uc011mhj.1	+							NM_001011719	NP_001011719			arylsulfatase family, member H							integral to membrane	arylsulfatase activity|metal ion binding			lung(1)	1		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)																---	---	---	---
WWC3	55841	broad.mit.edu	37	X	10094410	10094410	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:10094410delT	uc004csx.3	+						WWC3_uc010nds.2_Intron|WWC3_uc010ndt.2_Intron	NM_015691	NP_056506			WWC family member 3											ovary(4)	4																		---	---	---	---
ARHGAP6	395	broad.mit.edu	37	X	11243974	11243974	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:11243974delT	uc004cup.1	-						ARHGAP6_uc004cuo.1_Intron|ARHGAP6_uc004cur.1_Intron|ARHGAP6_uc004cum.1_Intron|ARHGAP6_uc004cun.1_Intron|ARHGAP6_uc010neb.1_Intron|ARHGAP6_uc011mif.1_Intron	NM_013427	NP_038286			Rho GTPase activating protein 6 isoform 1						actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			urinary_tract(1)|lung(1)	2																		---	---	---	---
MOSPD2	158747	broad.mit.edu	37	X	14913296	14913296	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:14913296delT	uc004cwi.2	+						MOSPD2_uc004cwj.2_Intron	NM_152581	NP_689794			motile sperm domain containing 2							integral to membrane	structural molecule activity			lung(1)	1	Hepatocellular(33;0.183)																	---	---	---	---
FIGF	2277	broad.mit.edu	37	X	15364159	15364159	+	3'UTR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:15364159delT	uc004cwt.1	-	7						NM_004469	NP_004460			vascular endothelial growth factor D						angiogenesis|cell differentiation|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of cell proliferation|positive regulation of mast cell chemotaxis|vascular endothelial growth factor receptor signaling pathway	extracellular space|membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity|platelet-derived growth factor receptor binding			ovary(1)|breast(1)|central_nervous_system(1)	3	Hepatocellular(33;0.183)																	---	---	---	---
TMEM27	57393	broad.mit.edu	37	X	15677316	15677317	+	Intron	DEL	CA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:15677316_15677317delCA	uc004cxc.1	-							NM_020665	NP_065716			transmembrane protein 27 precursor						proteolysis	integral to membrane	metallopeptidase activity|peptidyl-dipeptidase activity			ovary(1)	1	Hepatocellular(33;0.183)																	---	---	---	---
CTPS2	56474	broad.mit.edu	37	X	16688837	16688837	+	Intron	DEL	T	-	-	rs72340997		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:16688837delT	uc004cxk.2	-						CTPS2_uc004cxl.2_Intron|CTPS2_uc004cxm.2_Intron	NM_001144002	NP_001137474			cytidine triphosphate synthase II						glutamine metabolic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine nucleotide biosynthetic process	cytosol	ATP binding|CTP synthase activity			ovary(1)	1	Hepatocellular(33;0.0997)																	---	---	---	---
CDKL5	6792	broad.mit.edu	37	X	18616437	18616437	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:18616437delT	uc004cym.2	+						CDKL5_uc004cyn.2_Intron	NM_003159	NP_003150			cyclin-dependent kinase-like 5						neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			ovary(2)|large_intestine(1)|stomach(1)|central_nervous_system(1)|skin(1)	6	Hepatocellular(33;0.183)																	---	---	---	---
CDKL5	6792	broad.mit.edu	37	X	18664273	18664273	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:18664273delT	uc004cym.2	+						CDKL5_uc004cyn.2_Intron|RS1_uc004cyo.2_Intron	NM_003159	NP_003150			cyclin-dependent kinase-like 5						neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			ovary(2)|large_intestine(1)|stomach(1)|central_nervous_system(1)|skin(1)	6	Hepatocellular(33;0.183)																	---	---	---	---
PHKA2	5256	broad.mit.edu	37	X	18943752	18943752	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:18943752delA	uc004cyv.3	-						PHKA2_uc010nfg.1_Intron	NM_000292	NP_000283			phosphorylase kinase, alpha 2 (liver)						glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(1)|central_nervous_system(1)	2	Hepatocellular(33;0.183)																	---	---	---	---
RPS6KA3	6197	broad.mit.edu	37	X	20174513	20174513	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:20174513delA	uc004czu.2	-						RPS6KA3_uc011mjk.1_Intron|RPS6KA3_uc004czv.2_Intron|RPS6KA3_uc011mjl.1_Intron|RPS6KA3_uc011mjm.1_Intron	NM_004586	NP_004577			ribosomal protein S6 kinase, 90kDa, polypeptide						axon guidance|central nervous system development|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|skeletal system development|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(4)|stomach(1)|ovary(1)|lung(1)|breast(1)	8																		---	---	---	---
RPS6KA3	6197	broad.mit.edu	37	X	20206187	20206187	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:20206187delT	uc004czu.2	-						RPS6KA3_uc011mjk.1_Intron|RPS6KA3_uc004czv.2_Intron|RPS6KA3_uc011mjl.1_Intron|RPS6KA3_uc011mjm.1_Intron	NM_004586	NP_004577			ribosomal protein S6 kinase, 90kDa, polypeptide						axon guidance|central nervous system development|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|skeletal system development|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(4)|stomach(1)|ovary(1)|lung(1)|breast(1)	8																		---	---	---	---
Unknown	0	broad.mit.edu	37	X	20999152	20999153	+	IGR	DEL	AG	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:20999152_20999153delAG								RPS6KA3 (713629 upstream) : CNKSR2 (393827 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	X	24383621	24383621	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:24383621delT								FAM48B1 (81 upstream) : PDK3 (99723 downstream)																																			---	---	---	---
POLA1	5422	broad.mit.edu	37	X	24735994	24735995	+	Intron	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:24735994_24735995delTT	uc004dbl.2	+						POLA1_uc004dbm.2_Intron|POLA1_uc004dbn.2_Intron	NM_016937	NP_058633			DNA-directed DNA polymerase alpha 1						cell proliferation|DNA replication checkpoint|DNA replication, synthesis of RNA primer|DNA-dependent DNA replication initiation|double-strand break repair via nonhomologous end joining|interspecies interaction between organisms|lagging strand elongation|leading strand elongation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|cytoplasm|nuclear envelope|nuclear matrix|nucleolus|nucleoplasm	chromatin binding|DNA-directed DNA polymerase activity|metal ion binding|nucleoside binding			ovary(2)|skin(1)	3					Clofarabine(DB00631)|Fludarabine(DB01073)													---	---	---	---
IL1RAPL1	11141	broad.mit.edu	37	X	29301000	29301000	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:29301000delT	uc004dby.2	+							NM_014271	NP_055086			interleukin 1 receptor accessory protein-like 1						innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5																		---	---	---	---
DMD	1756	broad.mit.edu	37	X	32235010	32235011	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:32235010_32235011insA	uc004dda.1	-						DMD_uc004dcw.2_Intron|DMD_uc004dcx.2_Intron|DMD_uc004dcz.2_Intron|DMD_uc004dcy.1_Intron|DMD_uc004ddb.1_Intron|DMD_uc010ngo.1_Intron|DMD_uc010ngn.1_Intron	NM_004006	NP_003997			dystrophin Dp427m isoform						muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)																---	---	---	---
CXorf59	286464	broad.mit.edu	37	X	36089798	36089798	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:36089798delT	uc004ddk.1	+							NM_173695	NP_775966			hypothetical protein LOC286464							integral to membrane				central_nervous_system(1)	1																		---	---	---	---
PRRG1	5638	broad.mit.edu	37	X	37312611	37312611	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:37312611delC	uc004ddn.2	+	5	647	c.394delC	c.(394-396)CCCfs	p.P132fs	PRRG1_uc004ddo.2_Frame_Shift_Del_p.P132fs	NM_000950	NP_000941	O14668	TMG1_HUMAN	proline rich Gla (G-carboxyglutamic acid) 1	132	Cytoplasmic (Potential).|Poly-Pro.					extracellular region|integral to plasma membrane	calcium ion binding			ovary(1)|breast(1)	2																		---	---	---	---
DYNLT3	6990	broad.mit.edu	37	X	37699961	37699962	+	Intron	DEL	AT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:37699961_37699962delAT	uc004dds.2	-							NM_006520	NP_006511			dynein, light chain, Tctex-type 3						cell division|mitosis|regulation of mitotic cell cycle|transport	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|nucleus|plasma membrane	motor activity				0																		---	---	---	---
MED14	9282	broad.mit.edu	37	X	40513557	40513558	+	Intron	DEL	TC	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:40513557_40513558delTC	uc004dex.3	-						MED14_uc004dey.1_3'UTR	NM_004229	NP_004220			mediator complex subunit 14						androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(2)|kidney(1)|skin(1)	4																		---	---	---	---
USP9X	8239	broad.mit.edu	37	X	40999844	40999845	+	Intron	INS	-	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:40999844_40999845insT	uc004dfb.2	+						USP9X_uc004dfc.2_Intron	NM_001039590	NP_001034679			ubiquitin specific protease 9, X-linked isoform						BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6																		---	---	---	---
USP9X	8239	broad.mit.edu	37	X	41069604	41069604	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:41069604delT	uc004dfb.2	+						USP9X_uc004dfc.2_Intron	NM_001039590	NP_001034679			ubiquitin specific protease 9, X-linked isoform						BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6																		---	---	---	---
CASK	8573	broad.mit.edu	37	X	41469154	41469159	+	Splice_Site	DEL	TACATC	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:41469154_41469159delTACATC	uc004dfl.3	-	12	1201	c.1155_splice	c.e12+1	p.D385_splice	CASK_uc004dfk.3_Splice_Site_p.D200_splice|CASK_uc004dfm.3_Splice_Site_p.D385_splice|CASK_uc004dfn.3_Splice_Site_p.D379_splice	NM_003688	NP_003679			calcium/calmodulin-dependent serine protein						cell adhesion	actin cytoskeleton|cytoplasm|nucleus|plasma membrane	ATP binding|calmodulin binding|guanylate kinase activity|protein serine/threonine kinase activity			ovary(3)|lung(2)|stomach(1)	6																		---	---	---	---
PHF16	9767	broad.mit.edu	37	X	46884358	46884358	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:46884358delT	uc004dgx.2	+						PHF16_uc004dgy.2_Intron	NM_001077445	NP_001070913			PHD finger protein 16						histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding				0																		---	---	---	---
UBA1	7317	broad.mit.edu	37	X	47059187	47059187	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:47059187delT	uc004dhj.3	+						UBA1_uc004dhk.3_Intron	NM_153280	NP_695012			ubiquitin-activating enzyme E1						cell death|protein modification process		ATP binding|ligase activity|protein binding|small protein activating enzyme activity			ovary(1)	1																		---	---	---	---
USP11	8237	broad.mit.edu	37	X	47102785	47102785	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:47102785delC	uc004dhp.2	+						USP11_uc004dhq.2_Intron	NM_004651	NP_004642			ubiquitin specific peptidase 11						protein deubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)|lung(1)|central_nervous_system(1)	3																		---	---	---	---
CFP	5199	broad.mit.edu	37	X	47483960	47483962	+	Intron	DEL	TTT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:47483960_47483962delTTT	uc004dig.3	-						CFP_uc004dih.2_Intron|CFP_uc004dii.1_3'UTR|CFP_uc010nhu.2_3'UTR	NM_001145252	NP_001138724			complement factor properdin precursor						complement activation, alternative pathway|defense response to bacterium	extracellular space				breast(2)|lung(1)	3																		---	---	---	---
SSX3	10214	broad.mit.edu	37	X	48213309	48213309	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:48213309delT	uc004djd.1	-						SSX3_uc004dje.2_Intron|SSX3_uc010nic.2_Intron	NM_021014	NP_066294			synovial sarcoma, X breakpoint 3 isoform a						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding				0																		---	---	---	---
WDR13	64743	broad.mit.edu	37	X	48462533	48462533	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:48462533delA	uc004dkh.1	+						WDR13_uc004dki.1_Intron|WDR13_uc004dkj.1_Intron|WDR13_uc004dkk.1_Intron|WDR13_uc004dkl.3_Intron	NM_017883	NP_060353			WD repeat domain 13 protein							cytoplasm|nucleus				ovary(2)	2																		---	---	---	---
SMC1A	8243	broad.mit.edu	37	X	53438554	53438554	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:53438554delA	uc004dsg.2	-						SMC1A_uc011moe.1_Intron|SMC1A_uc011mof.1_Intron	NM_006306	NP_006297			structural maintenance of chromosomes 1A						cell cycle checkpoint|cell division|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic sister chromatid cohesion|mitotic spindle organization|negative regulation of DNA endoreduplication|nuclear mRNA splicing, via spliceosome|response to radiation|signal transduction in response to DNA damage	cohesin core heterodimer|condensed chromosome kinetochore|condensed nuclear chromosome|cytoplasm|meiotic cohesin complex|nucleoplasm	ATP binding|chromatin binding|microtubule motor activity|protein heterodimerization activity			ovary(5)|central_nervous_system(1)	6																		---	---	---	---
HUWE1	10075	broad.mit.edu	37	X	53652091	53652092	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:53652091_53652092insA	uc004dsp.2	-							NM_031407	NP_113584			HECT, UBA and WWE domain containing 1						base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17																		---	---	---	---
FAM120C	54954	broad.mit.edu	37	X	54160482	54160482	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:54160482delA	uc004dsz.3	-						FAM120C_uc011moh.1_Intron	NM_017848	NP_060318			hypothetical protein LOC54954											ovary(1)|central_nervous_system(1)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	X	57703526	57703526	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:57703526delT								ZXDB (79620 upstream) : ZXDA (230672 downstream)																																			---	---	---	---
MTMR8	55613	broad.mit.edu	37	X	63563610	63563610	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:63563610delA	uc004dvs.2	-						MTMR8_uc011mou.1_Intron|MTMR8_uc004dvt.1_Intron	NM_017677	NP_060147			myotubularin related protein 8							nuclear envelope	protein tyrosine phosphatase activity			ovary(2)|breast(2)	4																		---	---	---	---
MTMR8	55613	broad.mit.edu	37	X	63615100	63615100	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:63615100delC	uc004dvs.2	-						MTMR8_uc011mou.1_Intron|MTMR8_uc004dvt.1_Intron	NM_017677	NP_060147			myotubularin related protein 8							nuclear envelope	protein tyrosine phosphatase activity			ovary(2)|breast(2)	4																		---	---	---	---
LAS1L	81887	broad.mit.edu	37	X	64744167	64744167	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:64744167delG	uc004dwa.1	-						LAS1L_uc004dwc.1_Intron|LAS1L_uc004dwd.1_Intron	NM_031206	NP_112483			LAS1-like							MLL1 complex|nucleolus	protein binding			ovary(3)|large_intestine(1)	4																		---	---	---	---
HEPH	9843	broad.mit.edu	37	X	65426921	65426921	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:65426921delT	uc011moz.1	+						HEPH_uc004dwn.2_Intron|HEPH_uc004dwo.2_Intron|HEPH_uc010nkr.2_Intron|HEPH_uc011mpa.1_Intron|HEPH_uc010nks.2_Intron	NM_138737	NP_620074			hephaestin isoform a						cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9																		---	---	---	---
OPHN1	4983	broad.mit.edu	37	X	67417116	67417116	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:67417116delA	uc004dww.3	-						OPHN1_uc011mpg.1_Intron	NM_002547	NP_002538			oligophrenin 1						axon guidance|endocytosis|filopodium assembly|small GTPase mediated signal transduction|substrate-dependent cell migration, cell extension	axon|cell junction|cytosol|dendritic spine|synapse	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			ovary(2)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	X	68004997	68004998	+	IGR	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:68004997_68004998insA								STARD8 (59320 upstream) : EFNB1 (43842 downstream)																																			---	---	---	---
KIF4A	24137	broad.mit.edu	37	X	69622359	69622359	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:69622359delC	uc004dyg.2	+						KIF4A_uc010nkw.2_Intron	NM_012310	NP_036442			kinesin family member 4						anterograde axon cargo transport|axon guidance|blood coagulation|organelle organization	chromosome|cytosol|midbody|nuclear matrix|spindle microtubule	ATP binding|DNA binding|microtubule motor activity|protein binding			ovary(4)	4																		---	---	---	---
TEX11	56159	broad.mit.edu	37	X	69960654	69960654	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:69960654delA	uc004dyl.2	-						TEX11_uc004dym.2_Intron	NM_001003811	NP_001003811			testis expressed sequence 11 isoform 1								protein binding			ovary(3)|breast(1)|skin(1)	5	Renal(35;0.156)																	---	---	---	---
ZMYM3	9203	broad.mit.edu	37	X	70472962	70472963	+	Frame_Shift_Ins	INS	-	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:70472962_70472963insG	uc004dzh.1	-	2	230_231	c.143_144insC	c.(142-144)CCTfs	p.P48fs	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Frame_Shift_Ins_p.P48fs|ZMYM3_uc004dzj.1_Frame_Shift_Ins_p.P48fs|ZMYM3_uc011mpu.1_5'Flank|ZMYM3_uc004dzk.3_Frame_Shift_Ins_p.P48fs|ZMYM3_uc004dzl.3_Frame_Shift_Ins_p.P48fs|ZMYM3_uc004dzm.3_Frame_Shift_Ins_p.P48fs	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	48					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)															OREG0019858	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
OGT	8473	broad.mit.edu	37	X	70767677	70767677	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:70767677delT	uc004eaa.1	+						BCYRN1_uc011mpt.1_Intron|OGT_uc004eab.1_Intron|OGT_uc004eac.2_Frame_Shift_Del_p.L12fs|OGT_uc004ead.2_5'UTR	NM_181672	NP_858058			O-linked GlcNAc transferase isoform 1						cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			ovary(3)|kidney(1)|pancreas(1)	5	Renal(35;0.156)																	---	---	---	---
ACRC	93953	broad.mit.edu	37	X	70812215	70812215	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:70812215delT	uc004eae.2	+						BCYRN1_uc011mpt.1_Intron	NM_052957	NP_443189			ACRC protein							nucleus				ovary(3)	3	Renal(35;0.156)																	---	---	---	---
NHSL2	340527	broad.mit.edu	37	X	71264810	71264810	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:71264810delA	uc011mqa.1	+							NM_001013627	NP_001013649			NHS-like 2												0	Renal(35;0.156)																	---	---	---	---
Unknown	0	broad.mit.edu	37	X	71492424	71492425	+	IGR	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:71492424_71492425delAA								PIN4 (7612 upstream) : RPS4X (29 downstream)																																			---	---	---	---
NCRNA00182	100302692	broad.mit.edu	37	X	73393872	73393872	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:73393872delA	uc010nlq.1	-											Homo sapiens cDNA FLJ33139 fis, clone UTERU1000109.												0																		---	---	---	---
ZDHHC15	158866	broad.mit.edu	37	X	74604701	74604701	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:74604701delA	uc004ecg.2	-						ZDHHC15_uc004ech.2_Intron|ZDHHC15_uc011mqo.1_Intron	NM_144969	NP_659406			zinc finger, DHHC-type containing 15 isoform 1							integral to membrane	zinc ion binding			ovary(2)	2																		---	---	---	---
ZDHHC15	158866	broad.mit.edu	37	X	74670546	74670546	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:74670546delA	uc004ecg.2	-						ZDHHC15_uc004ech.2_Intron|ZDHHC15_uc011mqo.1_Intron|ZDHHC15_uc004eci.2_3'UTR	NM_144969	NP_659406			zinc finger, DHHC-type containing 15 isoform 1							integral to membrane	zinc ion binding			ovary(2)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	X	74805020	74805020	+	IGR	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:74805020delT								ZDHHC15 (61683 upstream) : MAGEE2 (197803 downstream)																																			---	---	---	---
MAGEE2	139599	broad.mit.edu	37	X	75004754	75004754	+	Frame_Shift_Del	DEL	G	-	-	rs61732441	byFrequency;by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:75004754delG	uc004ecj.1	-	1	318	c.133delC	c.(133-135)CAGfs	p.Q45fs		NM_138703	NP_619648	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	45										ovary(1)|skin(1)	2																		---	---	---	---
ATRX	546	broad.mit.edu	37	X	76953304	76953305	+	Intron	INS	-	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:76953304_76953305insA	uc004ecp.3	-						ATRX_uc004ecq.3_Intron|ATRX_uc004eco.3_Intron|ATRX_uc004ecr.2_Intron|ATRX_uc010nlx.1_Intron|ATRX_uc010nly.1_Intron	NM_000489	NP_000480			transcriptional regulator ATRX isoform 1						DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						---	---	---	---
TAF9B	51616	broad.mit.edu	37	X	77387116	77387118	+	In_Frame_Del	DEL	ATC	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:77387116_77387118delATC	uc004eda.2	-	7	816_818	c.745_747delGAT	c.(745-747)GATdel	p.D249del		NM_015975	NP_057059	Q9HBM6	TAF9B_HUMAN	transcription associated factor 9B	249	Poly-Asp.				negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell growth|transcription initiation, DNA-dependent	transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding				0																		---	---	---	---
LPAR4	2846	broad.mit.edu	37	X	78010355	78010355	+	5'UTR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:78010355delA	uc010nme.2	+	2						NM_005296	NP_005287			lysophosphatidic acid receptor 4							integral to plasma membrane	lipid binding|purinergic nucleotide receptor activity, G-protein coupled			ovary(3)	3																		---	---	---	---
BRWD3	254065	broad.mit.edu	37	X	79947491	79947492	+	Intron	DEL	AA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:79947491_79947492delAA	uc004edt.2	-						BRWD3_uc010nmi.1_Intron|BRWD3_uc004edo.2_Intron|BRWD3_uc004edp.2_Intron|BRWD3_uc004edq.2_Intron|BRWD3_uc010nmj.1_Intron|BRWD3_uc004edr.2_Intron|BRWD3_uc004eds.2_Intron|BRWD3_uc004edu.2_Intron|BRWD3_uc004edv.2_Intron|BRWD3_uc004edw.2_Intron|BRWD3_uc004edx.2_Intron|BRWD3_uc004edy.2_Intron|BRWD3_uc004edz.2_Intron|BRWD3_uc004eea.2_Intron|BRWD3_uc004eeb.2_Intron	NM_153252	NP_694984			bromodomain and WD repeat domain containing 3											ovary(4)	4																		---	---	---	---
BRWD3	254065	broad.mit.edu	37	X	79991591	79991591	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:79991591delA	uc004edt.2	-						BRWD3_uc004edo.2_Intron|BRWD3_uc004edp.2_Intron|BRWD3_uc004edq.2_Intron|BRWD3_uc010nmj.1_Intron|BRWD3_uc004edr.2_Intron|BRWD3_uc004eds.2_Intron|BRWD3_uc004edu.2_Intron|BRWD3_uc004edv.2_Intron|BRWD3_uc004edw.2_Intron|BRWD3_uc004edx.2_Intron|BRWD3_uc004edy.2_Intron|BRWD3_uc004edz.2_Intron|BRWD3_uc004eea.2_Intron|BRWD3_uc004eeb.2_Intron	NM_153252	NP_694984			bromodomain and WD repeat domain containing 3											ovary(4)	4																		---	---	---	---
APOOL	139322	broad.mit.edu	37	X	84309335	84309335	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:84309335delT	uc004eem.2	+						APOOL_uc010nmp.2_Intron	NM_198450	NP_940852			apolipoprotein O-like precursor							extracellular region					0																		---	---	---	---
POF1B	79983	broad.mit.edu	37	X	84534442	84534442	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:84534442delA	uc004eer.2	-							NM_024921	NP_079197			premature ovarian failure, 1B								actin binding				0																		---	---	---	---
BTK	695	broad.mit.edu	37	X	100629749	100629749	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:100629749delA	uc004ehg.2	-						BTK_uc010nnn.2_Intron|BTK_uc010nno.2_Intron|BTK_uc004ehi.2_Intron	NM_000061	NP_000052			Bruton agammaglobulinemia tyrosine kinase						calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding			lung(3)|central_nervous_system(2)|ovary(1)	6														Agammaglobulinemia_X-linked				---	---	---	---
NXF5	55998	broad.mit.edu	37	X	101093566	101093566	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:101093566delG	uc011mrk.1	-						NXF5_uc004eih.1_Intron|NXF5_uc004eii.1_Intron|NXF5_uc004eij.1_Intron|NXF5_uc004eik.1_Intron|NXF5_uc004eil.1_Intron	NM_032946	NP_116564			nuclear RNA export factor 5						mRNA export from nucleus|multicellular organismal development	actin cytoskeleton|cytoplasm|nucleus	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			central_nervous_system(1)	1																		---	---	---	---
TCEAL1	9338	broad.mit.edu	37	X	102884959	102884973	+	In_Frame_Del	DEL	TCGGAGGAGCAGTCC	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:102884959_102884973delTCGGAGGAGCAGTCC	uc004eks.2	+	3	289_303	c.115_129delTCGGAGGAGCAGTCC	c.(115-129)TCGGAGGAGCAGTCCdel	p.SEEQS39del	TCEAL1_uc004ekt.2_In_Frame_Del_p.SEEQS39del|TCEAL1_uc004eku.2_In_Frame_Del_p.SEEQS39del	NM_001006640	NP_001006641	Q15170	TCAL1_HUMAN	transcription elongation factor A (SII)-like 1	48_52	Arg/Ser-rich.				negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity	p.S39S(1)		ovary(1)	1																		---	---	---	---
TBC1D8B	54885	broad.mit.edu	37	X	106108892	106108892	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:106108892delT	uc004emo.2	+						MORC4_uc004emp.3_Intron	NM_017752	NP_060222			TBC1 domain family, member 8B (with GRAM domain)							intracellular	calcium ion binding|Rab GTPase activator activity			ovary(2)|central_nervous_system(1)|skin(1)	4																		---	---	---	---
COL4A6	1288	broad.mit.edu	37	X	107438186	107438186	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:107438186delA	uc004enw.3	-						COL4A6_uc004env.3_Intron|COL4A6_uc011msn.1_Intron|COL4A6_uc010npk.2_Intron	NM_001847	NP_001838			type IV alpha 6 collagen isoform A precursor						cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(6)|urinary_tract(1)|large_intestine(1)	8														Alport_syndrome_with_Diffuse_Leiomyomatosis				---	---	---	---
COL4A5	1287	broad.mit.edu	37	X	107850252	107850252	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:107850252delT	uc004enz.1	+						COL4A5_uc011mso.1_Intron|COL4A5_uc004eob.1_Intron	NM_033380	NP_203699			type IV collagen alpha 5 isoform 2 precursor						axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4														Alport_syndrome_with_Diffuse_Leiomyomatosis				---	---	---	---
TMEM164	84187	broad.mit.edu	37	X	109387871	109387871	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:109387871delT	uc004eom.2	+						TMEM164_uc004eol.2_Intron|TMEM164_uc010npq.2_Intron	NM_032227	NP_115603			transmembrane protein 164 isoform b							integral to membrane				large_intestine(1)|lung(1)|skin(1)	3																		---	---	---	---
PAK3	5063	broad.mit.edu	37	X	110366281	110366281	+	5'Flank	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:110366281delT	uc004epa.2	+						PAK3_uc010npt.1_Intron|PAK3_uc010npu.1_Intron|PAK3_uc004eoy.1_Intron|PAK3_uc004eoz.2_Intron|PAK3_uc011mst.1_Intron|PAK3_uc010npv.1_5'Flank|PAK3_uc010npw.1_5'Flank|uc004epb.2_5'Flank	NM_001128173	NP_001121645			p21-activated kinase 3 isoform d						multicellular organismal development		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding			lung(6)|ovary(3)|large_intestine(1)	10															TSP Lung(19;0.15)			---	---	---	---
CAPN6	827	broad.mit.edu	37	X	110506864	110506864	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:110506864delA	uc004epc.1	-						CAPN6_uc011msu.1_Intron	NM_014289	NP_055104			calpain 6						microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|skin(1)	6																		---	---	---	---
LRCH2	57631	broad.mit.edu	37	X	114347905	114347905	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:114347905delA	uc010nqe.2	-						LRCH2_uc004epz.2_Intron	NM_020871	NP_065922			leucine-rich repeats and calponin homology (CH)											ovary(1)	1																		---	---	---	---
AGTR2	186	broad.mit.edu	37	X	115303402	115303402	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:115303402delT	uc004eqh.3	+							NM_000686	NP_000677			angiotensin II receptor, type 2						behavior|blood vessel remodeling|brain development|G-protein signaling, coupled to cGMP nucleotide second messenger|intracellular protein kinase cascade|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of heart rate|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of nitric-oxide synthase activity|positive regulation of phosphoprotein phosphatase activity|positive regulation of vasodilation|regulation of systemic arterial blood pressure by circulatory renin-angiotensin		angiotensin type II receptor activity|receptor antagonist activity			ovary(2)|lung(1)	3																		---	---	---	---
WDR44	54521	broad.mit.edu	37	X	117480600	117480600	+	Intron	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:117480600delG	uc004eqn.2	+						WDR44_uc004eqo.2_Intron|WDR44_uc011mtr.1_Intron	NM_019045	NP_061918			WD repeat domain 44 protein							cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				lung(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5																		---	---	---	---
WDR44	54521	broad.mit.edu	37	X	117520459	117520459	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:117520459delT	uc004eqn.2	+						WDR44_uc004eqo.2_Intron|WDR44_uc011mtr.1_Intron	NM_019045	NP_061918			WD repeat domain 44 protein							cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				lung(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5																		---	---	---	---
DOCK11	139818	broad.mit.edu	37	X	117733260	117733260	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:117733260delA	uc004eqp.2	+						DOCK11_uc004eqq.2_Intron	NM_144658	NP_653259			dedicator of cytokinesis 11						blood coagulation	cytosol	GTP binding			ovary(3)	3																		---	---	---	---
IL13RA1	3597	broad.mit.edu	37	X	117907665	117907665	+	Intron	DEL	T	-	-	rs3838204		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:117907665delT	uc004eqs.2	+						IL13RA1_uc004eqt.1_Intron	NM_001560	NP_001551			interleukin 13 receptor, alpha 1 precursor							interleukin-13 receptor complex	cytokine receptor activity				0																		---	---	---	---
LONRF3	79836	broad.mit.edu	37	X	118143077	118143077	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:118143077delC	uc004eqw.2	+						LONRF3_uc004eqx.2_Intron|LONRF3_uc004eqy.2_Intron|LONRF3_uc004eqz.2_Intron	NM_001031855	NP_001027026			LON peptidase N-terminal domain and ring finger						proteolysis		ATP-dependent peptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)	2																		---	---	---	---
UBE2A	7319	broad.mit.edu	37	X	118716913	118716915	+	Intron	DEL	AAA	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:118716913_118716915delAAA	uc004erl.2	+						UBE2A_uc004erm.2_Intron|UBE2A_uc004ern.2_Intron|UBE2A_uc004ero.2_Intron|UBE2A_uc004erp.2_Intron	NM_003336	NP_003327			ubiquitin-conjugating enzyme E2A isoform 1						histone H2A ubiquitination|positive regulation of cell proliferation|postreplication repair|protein autoubiquitination|protein K11-linked ubiquitination|protein K48-linked ubiquitination|response to UV|ubiquitin-dependent protein catabolic process		ATP binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity				0													Direct_reversal_of_damage|Rad6_pathway					---	---	---	---
SEPT6	23157	broad.mit.edu	37	X	118752622	118752622	+	3'UTR	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:118752622delG	uc004erv.2	-	10					SEPT6_uc010nqk.2_Intron|SEPT6_uc004ers.2_Intron|SEPT6_uc004ert.2_Intron|SEPT6_uc004eru.2_3'UTR	NM_015129	NP_055944			septin 6 isoform B						cell cycle|cytokinesis|interspecies interaction between organisms	cleavage furrow|condensed chromosome kinetochore|midbody|septin complex|spindle	GTP binding|protein binding			lung(1)|ovary(1)|prostate(1)|kidney(1)	4																		---	---	---	---
NDUFA1	4694	broad.mit.edu	37	X	119007510	119007510	+	Intron	DEL	T	-	-	rs67229707		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:119007510delT	uc004esc.3	+						RNF113A_uc004esb.2_5'Flank	NM_004541	NP_004532			NADH dehydrogenase (ubiquinone) 1 alpha						mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			large_intestine(1)	1					NADH(DB00157)													---	---	---	---
THOC2	57187	broad.mit.edu	37	X	122830465	122830465	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:122830465delA	uc004etu.2	-						THOC2_uc011muh.1_Intron|THOC2_uc011mui.1_Intron	NM_001081550	NP_001075019			THO complex 2						intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3																		---	---	---	---
ODZ1	10178	broad.mit.edu	37	X	123838785	123838785	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:123838785delA	uc004euj.2	-						ODZ1_uc011muj.1_Intron|ODZ1_uc010nqy.2_Intron	NM_014253	NP_055068			odz, odd Oz/ten-m homolog 1 isoform 3						immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23																		---	---	---	---
ODZ1	10178	broad.mit.edu	37	X	124097630	124097630	+	5'UTR	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:124097630delA	uc004euj.2	-	1					ODZ1_uc011muj.1_5'UTR|ODZ1_uc010nqy.2_5'UTR	NM_014253	NP_055068			odz, odd Oz/ten-m homolog 1 isoform 3						immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23																		---	---	---	---
AIFM1	9131	broad.mit.edu	37	X	129281916	129281916	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:129281916delA	uc004evg.2	-						AIFM1_uc011mus.1_Intron|AIFM1_uc004evh.2_Intron|AIFM1_uc004evi.2_Intron|AIFM1_uc004evk.2_Intron	NM_004208	NP_004199			programmed cell death 8 isoform 1						activation of caspase activity|apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytosol|mitochondrial inner membrane|mitochondrial intermembrane space|nucleus|perinuclear region of cytoplasm	DNA binding|electron carrier activity|flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			ovary(4)|central_nervous_system(1)	5																		---	---	---	---
ARHGAP36	158763	broad.mit.edu	37	X	130222789	130222789	+	3'UTR	DEL	G	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:130222789delG	uc004evz.2	+	12					ARHGAP36_uc004ewa.2_3'UTR|ARHGAP36_uc004ewb.2_3'UTR|ARHGAP36_uc004ewc.2_3'UTR	NM_144967	NP_659404			hypothetical protein LOC158763 precursor						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)	3																		---	---	---	---
HPRT1	3251	broad.mit.edu	37	X	133609078	133609079	+	Intron	DEL	TT	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:133609078_133609079delTT	uc004exl.3	+						HPRT1_uc010nrs.2_Intron	NM_000194	NP_000185			hypoxanthine phosphoribosyltransferase 1						adenine salvage|central nervous system neuron development|cerebral cortex neuron differentiation|cytolysis|dendrite morphogenesis|GMP catabolic process|GMP salvage|grooming behavior|guanine salvage|hypoxanthine salvage|IMP salvage|lymphocyte proliferation|positive regulation of dopamine metabolic process|protein homotetramerization|purine ribonucleoside salvage|response to amphetamine|striatum development	cytosol	guanine phosphoribosyltransferase activity|hypoxanthine phosphoribosyltransferase activity|magnesium ion binding|nucleotide binding|protein homodimerization activity				0	Acute lymphoblastic leukemia(192;0.000127)				Mercaptopurine(DB01033)|Thioguanine(DB00352)													---	---	---	---
PLAC1	10761	broad.mit.edu	37	X	133699960	133699961	+	3'UTR	DEL	TC	-	-	rs1982	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:133699960_133699961delTC	uc004exo.1	-	3					PLAC1_uc004exp.1_3'UTR	NM_021796	NP_068568			placenta-specific 1 precursor						placenta development	extracellular region				pancreas(1)	1	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
DDX26B	203522	broad.mit.edu	37	X	134708145	134708145	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:134708145delT	uc004eyw.3	+						DDX26B_uc004eyx.3_Intron	NM_182540	NP_872346			DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide												0	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
GPR112	139378	broad.mit.edu	37	X	135482406	135482406	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:135482406delT	uc004ezu.1	+						GPR112_uc010nsb.1_Intron	NM_153834	NP_722576			G-protein coupled receptor 112						neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
HTATSF1	27336	broad.mit.edu	37	X	135586663	135586663	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:135586663delT	uc004ezw.2	+						HTATSF1_uc004ezx.2_Intron	NM_001163280	NP_001156752			HIV-1 Tat specific factor 1						regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|viral genome replication	nucleus	nucleotide binding|protein binding|RNA binding			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
ARHGEF6	9459	broad.mit.edu	37	X	135765124	135765124	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:135765124delT	uc004fab.2	-						ARHGEF6_uc011mwd.1_Intron|ARHGEF6_uc011mwe.1_Intron	NM_004840	NP_004831			Rac/Cdc42 guanine nucleotide exchange factor 6						apoptosis|cell junction assembly|induction of apoptosis by extracellular signals|JNK cascade|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity				0	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
PASD1	139135	broad.mit.edu	37	X	150816900	150816900	+	Intron	DEL	T	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:150816900delT	uc004fev.3	+							NM_173493	NP_775764			PAS domain containing 1							nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
SRPK3	26576	broad.mit.edu	37	X	153048649	153048649	+	Intron	DEL	C	-	-	rs72481508		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153048649delC	uc004fil.2	+						SRPK3_uc004fik.2_Intron|SRPK3_uc010nul.2_Intron|SRPK3_uc004fin.2_Intron|SRPK3_uc004fim.2_Intron	NM_014370	NP_055185			serine arginine rich protein-specific kinase 3						cell differentiation|muscle organ development|muscle tissue development		ATP binding|protein serine/threonine kinase activity			pancreas(2)|lung(1)	3	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
HCFC1	3054	broad.mit.edu	37	X	153222541	153222541	+	Intron	DEL	C	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153222541delC	uc004fjp.2	-							NM_005334	NP_005325			host cell factor 1						cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
DKC1	1736	broad.mit.edu	37	X	153994771	153994771	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153994771delA	uc004fmm.2	+						DKC1_uc010nvf.2_Intron|SNORA36A_uc004fmn.2_5'Flank	NM_001363	NP_001354			dyskerin isoform 1						cell proliferation|pseudouridine synthesis|rRNA processing|telomere maintenance via telomerase	Cajal body|nucleolus|telomerase holoenzyme complex	protein binding|pseudouridine synthase activity|RNA binding|telomerase activity				0	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)													Congenital_Dyskeratosis				---	---	---	---
MTCP1	4515	broad.mit.edu	37	X	154293679	154293679	+	Intron	DEL	A	-	-			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:154293679delA	uc004fmz.2	-						MTCP1NB_uc004fmy.2_Intron	NM_001018025	NP_001018025			mature T-cell proliferation 1						cell proliferation					lung(1)	1	all_cancers(53;3.51e-17)|all_epithelial(53;5.13e-11)|all_lung(58;3.84e-07)|Lung NSC(58;1.2e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)							T	TRA@	T cell prolymphocytic leukemia								---	---	---	---
RAB39B	116442	broad.mit.edu	37	X	154490633	154490634	+	Intron	INS	-	TT	TT			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:154490633_154490634insTT	uc004fne.2	-							NM_171998	NP_741995			RAB39B, member RAS oncogene family						protein transport|small GTPase mediated signal transduction|synapse organization|vesicle-mediated transport	Golgi apparatus|plasma membrane	GTP binding				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)																	---	---	---	---
KLHL17	339451	broad.mit.edu	37	1	900458	900458	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:900458G>A	uc001aca.1	+	12	1923	c.1816G>A	c.(1816-1818)GCC>ACC	p.A606T	KLHL17_uc001acc.1_RNA|PLEKHN1_uc001acd.2_5'Flank|PLEKHN1_uc001acf.2_5'Flank|PLEKHN1_uc001ace.2_5'Flank	NM_198317	NP_938073	Q6TDP4	KLH17_HUMAN	kelch-like 17	606	Kelch 6.|Interaction with F-actin (By similarity).				actin cytoskeleton organization	actin cytoskeleton|cell junction|postsynaptic density|postsynaptic membrane	protein complex scaffold				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.52e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.59e-23)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.000469)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)														---	---	---	---
AGRN	375790	broad.mit.edu	37	1	989347	989347	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:989347G>A	uc001ack.1	+	34	5916	c.5866G>A	c.(5866-5868)GTG>ATG	p.V1956M		NM_198576	NP_940978	O00468	AGRIN_HUMAN	agrin precursor	1956	Laminin G-like 3.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)														---	---	---	---
MIB2	142678	broad.mit.edu	37	1	1559291	1559291	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:1559291G>A	uc001agg.2	+	4	686	c.559G>A	c.(559-561)GCC>ACC	p.A187T	MIB2_uc001agh.2_Missense_Mutation_p.A173T|MIB2_uc001agi.2_Missense_Mutation_p.A187T|MIB2_uc001agj.2_Missense_Mutation_p.A28T|MIB2_uc001agk.2_Missense_Mutation_p.A187T|MIB2_uc001agl.1_Missense_Mutation_p.A143T|MIB2_uc001agm.2_Missense_Mutation_p.A129T|MIB2_uc010nyq.1_Missense_Mutation_p.A143T|MIB2_uc009vkh.2_Missense_Mutation_p.A28T|MIB2_uc001agn.2_5'Flank	NM_080875	NP_543151	Q96AX9	MIB2_HUMAN	mindbomb homolog 2	187	ZZ-type.				Notch signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade	endosome	actin binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.26e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.54e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|BRCA - Breast invasive adenocarcinoma(365;0.00786)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)														---	---	---	---
SKI	6497	broad.mit.edu	37	1	2234752	2234752	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:2234752G>A	uc001aja.3	+	3	1196	c.1124G>A	c.(1123-1125)CGC>CAC	p.R375H		NM_003036	NP_003027	P12755	SKI_HUMAN	v-ski sarcoma viral oncogene homolog	375					anterior/posterior axis specification|BMP signaling pathway|bone morphogenesis|cell motility|cell proliferation|embryonic limb morphogenesis|face morphogenesis|lens morphogenesis in camera-type eye|myelination in peripheral nervous system|myotube differentiation|negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of fibroblast proliferation|negative regulation of osteoblast differentiation|negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|neural tube closure|nose morphogenesis|olfactory bulb development|palate development|positive regulation of DNA binding|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|protein homotrimerization|regulation of apoptosis|retina development in camera-type eye|skeletal muscle fiber development|SMAD protein signal transduction|somatic stem cell maintenance|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|PML body|transcription factor complex|transcriptional repressor complex	histone deacetylase inhibitor activity|nucleotide binding|protein domain specific binding|protein kinase binding|repressing transcription factor binding|SMAD binding|transcription corepressor activity|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding			lung(1)|central_nervous_system(1)	2	all_cancers(77;0.000139)|all_epithelial(69;4.45e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)			Epithelial(90;2.14e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.72e-29)|GBM - Glioblastoma multiforme(42;2.45e-08)|Colorectal(212;5.33e-05)|COAD - Colon adenocarcinoma(227;0.000228)|Kidney(185;0.00268)|BRCA - Breast invasive adenocarcinoma(365;0.00471)|STAD - Stomach adenocarcinoma(132;0.0147)|KIRC - Kidney renal clear cell carcinoma(229;0.0385)|Lung(427;0.207)														---	---	---	---
MMEL1	79258	broad.mit.edu	37	1	2522446	2522446	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:2522446G>A	uc001ajy.2	-	24	2537	c.2323C>T	c.(2323-2325)CGA>TGA	p.R775*	C1orf93_uc001aju.1_3'UTR|C1orf93_uc001ajw.1_3'UTR|C1orf93_uc001ajv.1_3'UTR|C1orf93_uc010nzd.1_3'UTR|C1orf93_uc010nze.1_3'UTR|C1orf93_uc010nzf.1_3'UTR|C1orf93_uc001ajx.1_3'UTR|MMEL1_uc009vlg.1_RNA	NM_033467	NP_258428	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	775	Lumenal (Potential).				proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity				0	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)														---	---	---	---
PRDM16	63976	broad.mit.edu	37	1	3328339	3328339	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:3328339G>A	uc001akf.2	+	9	1658	c.1578G>A	c.(1576-1578)CCG>CCA	p.P526P	PRDM16_uc001akc.2_Silent_p.P526P|PRDM16_uc001akd.2_Silent_p.P526P|PRDM16_uc001ake.2_Silent_p.P526P|PRDM16_uc009vlh.2_Silent_p.P227P	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	526	Pro-rich.				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)				T	EVI1	MDS|AML								---	---	---	---
ARHGEF16	27237	broad.mit.edu	37	1	3394493	3394493	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:3394493T>C	uc001akg.3	+	11	1776	c.1528T>C	c.(1528-1530)TTA>CTA	p.L510L	ARHGEF16_uc001aki.2_Silent_p.L222L|ARHGEF16_uc001akj.2_Silent_p.L222L|ARHGEF16_uc010nzh.1_Silent_p.L214L	NM_014448	NP_055263	Q5VV41	ARHGG_HUMAN	Rho guanine exchange factor 16	510	PH.				activation of Cdc42 GTPase activity|activation of Rac GTPase activity|apoptosis|cell chemotaxis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|small GTPase mediated signal transduction	cytosol	PDZ domain binding|receptor tyrosine kinase binding|Rho GTPase binding|Rho guanyl-nucleotide exchange factor activity			ovary(1)	1	all_cancers(77;0.00276)|all_epithelial(69;0.00102)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.101)	all_epithelial(116;7.14e-21)|all_lung(118;2.24e-08)|Lung NSC(185;3.55e-06)|Breast(487;0.000765)|Renal(390;0.00121)|Hepatocellular(190;0.0046)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.211)		Epithelial(90;8.62e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.62e-22)|GBM - Glioblastoma multiforme(42;2.49e-12)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.000681)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)														---	---	---	---
MEGF6	1953	broad.mit.edu	37	1	3428619	3428619	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:3428619G>A	uc001akl.2	-	8	1154	c.927C>T	c.(925-927)TGC>TGT	p.C309C	MEGF6_uc001akk.2_Silent_p.C204C	NM_001409	NP_001400	O75095	MEGF6_HUMAN	EGF-like-domain, multiple 3 precursor	309	EGF-like 5; calcium-binding (Potential).					extracellular region	calcium ion binding			large_intestine(1)	1	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)														---	---	---	---
LRRC47	57470	broad.mit.edu	37	1	3703715	3703715	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:3703715G>A	uc001akx.1	-	2	803	c.775C>T	c.(775-777)CGC>TGC	p.R259C		NM_020710	NP_065761	Q8N1G4	LRC47_HUMAN	leucine rich repeat containing 47	259					translation		phenylalanine-tRNA ligase activity|RNA binding			large_intestine(1)|ovary(1)	2	all_cancers(77;0.0375)|Ovarian(185;0.0634)|all_lung(157;0.208)|Lung NSC(156;0.21)	all_epithelial(116;1.34e-16)|all_lung(118;2.53e-06)|Lung NSC(185;0.00028)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.0743)|Ovarian(437;0.127)		Epithelial(90;5.49e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.43e-22)|GBM - Glioblastoma multiforme(42;3.69e-16)|Colorectal(212;1.21e-05)|COAD - Colon adenocarcinoma(227;5.87e-05)|Kidney(185;0.000367)|BRCA - Breast invasive adenocarcinoma(365;0.000704)|KIRC - Kidney renal clear cell carcinoma(229;0.00567)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.124)														---	---	---	---
NPHP4	261734	broad.mit.edu	37	1	6021934	6021934	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:6021934G>A	uc001alq.1	-	6	859	c.593C>T	c.(592-594)GCG>GTG	p.A198V	NPHP4_uc001als.1_RNA|NPHP4_uc009vlt.1_RNA|NPHP4_uc001alt.1_RNA	NM_015102	NP_055917	O75161	NPHP4_HUMAN	nephroretinin	198					actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			pancreas(1)	1	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
THAP3	90326	broad.mit.edu	37	1	6688663	6688663	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:6688663G>A	uc001aoc.2	+	3	338	c.179G>A	c.(178-180)CGG>CAG	p.R60Q	THAP3_uc001aod.2_Missense_Mutation_p.R60Q|THAP3_uc001aoe.1_Missense_Mutation_p.R60Q			Q8WTV1	THAP3_HUMAN	RecName: Full=THAP domain-containing protein 3;	60	THAP-type.						DNA binding|metal ion binding				0	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)														---	---	---	---
THAP3	90326	broad.mit.edu	37	1	6688716	6688716	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:6688716G>A	uc001aoc.2	+	3	391	c.232G>A	c.(232-234)GTG>ATG	p.V78M	THAP3_uc001aod.2_Missense_Mutation_p.V78M|THAP3_uc001aoe.1_Missense_Mutation_p.V78M			Q8WTV1	THAP3_HUMAN	RecName: Full=THAP domain-containing protein 3;	78	THAP-type.						DNA binding|metal ion binding				0	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)														---	---	---	---
DNAJC11	55735	broad.mit.edu	37	1	6704674	6704674	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:6704674G>A	uc001aof.2	-	10	1147	c.1041C>T	c.(1039-1041)AGC>AGT	p.S347S	DNAJC11_uc010nzt.1_Intron|DNAJC11_uc001aog.2_Silent_p.S347S|DNAJC11_uc010nzu.1_Silent_p.S257S	NM_018198	NP_060668	Q9NVH1	DJC11_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 11	347					protein folding		heat shock protein binding|unfolded protein binding			ovary(1)|skin(1)	2	Ovarian(185;0.0265)|all_lung(157;0.154)	all_cancers(23;1.97e-27)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;2.34e-07)|COAD - Colon adenocarcinoma(227;2.05e-05)|Kidney(185;7.67e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000639)|KIRC - Kidney renal clear cell carcinoma(229;0.00128)|STAD - Stomach adenocarcinoma(132;0.00179)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
H6PD	9563	broad.mit.edu	37	1	9305054	9305054	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:9305054G>A	uc001apt.2	+	2	334	c.61G>A	c.(61-63)GAG>AAG	p.E21K		NM_004285	NP_004276	O95479	G6PE_HUMAN	hexose-6-phosphate dehydrogenase precursor	21	Glucose 1-dehydrogenase.					endoplasmic reticulum lumen	6-phosphogluconolactonase activity|glucose 1-dehydrogenase|glucose-6-phosphate dehydrogenase activity|NADP binding				0	all_lung(157;0.23)	all_epithelial(116;1.28e-19)|all_lung(118;5.22e-06)|Lung NSC(185;1.98e-05)|Renal(390;0.000147)|Breast(348;0.00109)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.88e-07)|COAD - Colon adenocarcinoma(227;7.47e-05)|Kidney(185;0.000244)|KIRC - Kidney renal clear cell carcinoma(229;0.000905)|STAD - Stomach adenocarcinoma(132;0.00176)|BRCA - Breast invasive adenocarcinoma(304;0.00183)|READ - Rectum adenocarcinoma(331;0.0419)	NADH(DB00157)													---	---	---	---
H6PD	9563	broad.mit.edu	37	1	9305488	9305488	+	Silent	SNP	C	T	T	rs143453022		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:9305488C>T	uc001apt.2	+	2	768	c.495C>T	c.(493-495)GGC>GGT	p.G165G		NM_004285	NP_004276	O95479	G6PE_HUMAN	hexose-6-phosphate dehydrogenase precursor	165	Glucose 1-dehydrogenase.					endoplasmic reticulum lumen	6-phosphogluconolactonase activity|glucose 1-dehydrogenase|glucose-6-phosphate dehydrogenase activity|NADP binding				0	all_lung(157;0.23)	all_epithelial(116;1.28e-19)|all_lung(118;5.22e-06)|Lung NSC(185;1.98e-05)|Renal(390;0.000147)|Breast(348;0.00109)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.88e-07)|COAD - Colon adenocarcinoma(227;7.47e-05)|Kidney(185;0.000244)|KIRC - Kidney renal clear cell carcinoma(229;0.000905)|STAD - Stomach adenocarcinoma(132;0.00176)|BRCA - Breast invasive adenocarcinoma(304;0.00183)|READ - Rectum adenocarcinoma(331;0.0419)	NADH(DB00157)													---	---	---	---
UBE4B	10277	broad.mit.edu	37	1	10207065	10207065	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:10207065C>T	uc001aqs.3	+	19	3221	c.2508C>T	c.(2506-2508)GAC>GAT	p.D836D	UBE4B_uc001aqr.3_Silent_p.D707D|UBE4B_uc010oai.1_RNA|UBE4B_uc010oaj.1_Silent_p.D291D|UBE4B_uc001aqt.1_Silent_p.D176D	NM_001105562	NP_001099032	O95155	UBE4B_HUMAN	ubiquitination factor E4B isoform 1	836					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			ovary(2)|skin(2)	4		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)														---	---	---	---
CORT	1325	broad.mit.edu	37	1	10510294	10510294	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:10510294C>A	uc001ari.2	+	1	324	c.164C>A	c.(163-165)CCC>CAC	p.P55H	APITD1_uc001arf.2_Intron|APITD1_uc001arg.2_Intron	NM_001302	NP_001293	O00230	CORT_HUMAN	cortistatin preproprotein	5					inhibition of adenylate cyclase activity by G-protein signaling pathway|synaptic transmission	extracellular region|soluble fraction	G-protein-coupled receptor binding|neuropeptide hormone activity				0	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.12e-07)|COAD - Colon adenocarcinoma(227;7.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.0165)|READ - Rectum adenocarcinoma(331;0.0487)														---	---	---	---
PEX14	5195	broad.mit.edu	37	1	10659294	10659294	+	Splice_Site	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:10659294G>T	uc001arn.2	+	4	191	c.170_splice	c.e4-1	p.G57_splice	PEX14_uc009vmu.1_Intron|PEX14_uc009vmv.2_Splice_Site|PEX14_uc010oam.1_Splice_Site|PEX14_uc010oan.1_Intron|PEX14_uc009vmw.2_Splice_Site	NM_004565	NP_004556			peroxisomal biogenesis factor 14						negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|protein homooligomerization|protein import into peroxisome matrix|transmembrane transport	integral to membrane|nucleus|peroxisomal membrane|protein complex	protein N-terminus binding|transcription corepressor activity			breast(1)	1	Ovarian(185;0.203)	all_lung(284;6.02e-06)|Lung NSC(185;9.62e-06)|Renal(390;0.000147)|Breast(348;0.000932)|Colorectal(325;0.00215)|Hepatocellular(190;0.00913)|Ovarian(437;0.023)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0292)|Colorectal(212;9.13e-08)|COAD - Colon adenocarcinoma(227;2.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000482)|Kidney(185;0.00174)|KIRC - Kidney renal clear cell carcinoma(229;0.00457)|STAD - Stomach adenocarcinoma(132;0.0249)|READ - Rectum adenocarcinoma(331;0.0419)														---	---	---	---
PTCHD2	57540	broad.mit.edu	37	1	11580806	11580806	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:11580806C>T	uc001ash.3	+	10	2401	c.2263C>T	c.(2263-2265)CGG>TGG	p.R755W	PTCHD2_uc001asi.1_Missense_Mutation_p.R755W	NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	755	Extracellular (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)														---	---	---	---
FBXO6	26270	broad.mit.edu	37	1	11728893	11728893	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:11728893C>T	uc001aso.2	+	2	344	c.178C>T	c.(178-180)CGA>TGA	p.R60*		NM_018438	NP_060908	Q9NRD1	FBX6_HUMAN	F-box only protein 6	60					DNA damage checkpoint|DNA repair|ER-associated protein catabolic process|response to unfolded protein|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	glycoprotein binding			lung(1)	1	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.25e-06)|COAD - Colon adenocarcinoma(227;0.000251)|BRCA - Breast invasive adenocarcinoma(304;0.000297)|Kidney(185;0.000747)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
TNFRSF8	943	broad.mit.edu	37	1	12202468	12202468	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:12202468T>C	uc001atq.2	+	15	1890	c.1668T>C	c.(1666-1668)CAT>CAC	p.H556H	TNFRSF8_uc010obc.1_Silent_p.H444H|TNFRSF8_uc001atr.2_Silent_p.H93H|TNFRSF8_uc001ats.2_Silent_p.H37H	NM_001243	NP_001234	P28908	TNR8_HUMAN	tumor necrosis factor receptor superfamily,	556	Cytoplasmic (Potential).				cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane				skin(2)|ovary(1)|pancreas(1)|central_nervous_system(1)	5	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
CTRC	11330	broad.mit.edu	37	1	15771162	15771162	+	Silent	SNP	G	A	A	rs113087202	byFrequency	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:15771162G>A	uc001awi.1	+	6	578	c.555G>A	c.(553-555)ACG>ACA	p.T185T	CTRC_uc001awj.1_Intron	NM_007272	NP_009203	Q99895	CTRC_HUMAN	chymotrypsin C preproprotein	185	Peptidase S1.				proteolysis		serine-type endopeptidase activity				0		Breast(348;0.000207)|all_lung(284;0.00021)|Colorectal(325;0.000257)|Lung NSC(340;0.000269)|Renal(390;0.000518)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)|Hepatocellular(190;0.0634)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
FBLIM1	54751	broad.mit.edu	37	1	16091539	16091539	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:16091539C>T	uc001axd.1	+	4	504	c.61C>T	c.(61-63)CGC>TGC	p.R21C	FBLIM1_uc001axe.1_Missense_Mutation_p.R21C|FBLIM1_uc001axf.2_RNA|FBLIM1_uc001axg.1_Missense_Mutation_p.R21C|FBLIM1_uc001axh.1_Missense_Mutation_p.R21C|FBLIM1_uc001axi.1_Missense_Mutation_p.R21C	NM_017556	NP_060026	Q8WUP2	FBLI1_HUMAN	filamin-binding LIM protein-1 isoform a	21	Filamin-binding.				cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytoskeleton|cytosol|focal adhesion|intracellular membrane-bounded organelle	zinc ion binding			skin(1)	1		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|READ - Rectum adenocarcinoma(331;0.0649)|STAD - Stomach adenocarcinoma(313;0.138)														---	---	---	---
SPEN	23013	broad.mit.edu	37	1	16200878	16200878	+	Intron	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:16200878A>G	uc001axk.1	+						SPEN_uc010obp.1_Missense_Mutation_p.H90R	NM_015001	NP_055816			spen homolog, transcriptional regulator						interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)														---	---	---	---
SPEN	23013	broad.mit.edu	37	1	16203108	16203108	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:16203108C>T	uc001axk.1	+	3	1020	c.816C>T	c.(814-816)AGC>AGT	p.S272S	SPEN_uc010obp.1_Silent_p.S231S	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	272	Ser-rich.|Arg-rich.|By similarity.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)														---	---	---	---
EPHA2	1969	broad.mit.edu	37	1	16458656	16458656	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:16458656C>T	uc001aya.1	-	13	2365	c.2228G>A	c.(2227-2229)CGC>CAC	p.R743H		NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	743	Mediates interaction with ARHGEF16 and ELMO2.|Protein kinase.|Cytoplasmic (Potential).				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)													---	---	---	---
CROCC	9696	broad.mit.edu	37	1	17266547	17266547	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:17266547C>T	uc001azt.2	+	13	1836	c.1767C>T	c.(1765-1767)CGC>CGT	p.R589R	CROCC_uc009voy.1_Silent_p.R292R|CROCC_uc009voz.1_Silent_p.R352R|CROCC_uc001azu.2_5'UTR	NM_014675	NP_055490	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil	589	Potential.				cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			ovary(2)|breast(2)|central_nervous_system(1)	5		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)														---	---	---	---
ATP13A2	23400	broad.mit.edu	37	1	17332059	17332059	+	Intron	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:17332059C>T	uc001baa.2	-						ATP13A2_uc001bab.2_Intron|ATP13A2_uc001bac.2_Intron	NM_022089	NP_071372			ATPase type 13A2 isoform 1						ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;0.000147)|Breast(348;0.00104)|Renal(390;0.00145)|Lung NSC(340;0.00566)|all_lung(284;0.00797)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|COAD - Colon adenocarcinoma(227;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;1.99e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)														---	---	---	---
KLHDC7A	127707	broad.mit.edu	37	1	18809556	18809556	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:18809556G>A	uc001bax.2	+	1	2133	c.2081G>A	c.(2080-2082)CGC>CAC	p.R694H	KLHDC7A_uc009vpg.2_Missense_Mutation_p.R476H	NM_152375	NP_689588	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	694						integral to membrane				ovary(2)|upper_aerodigestive_tract(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
KIF17	57576	broad.mit.edu	37	1	21016738	21016738	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:21016738G>A	uc001bdr.3	-	7	1442	c.1324C>T	c.(1324-1326)CGC>TGC	p.R442C	KIF17_uc009vpx.2_5'UTR|KIF17_uc001bds.3_Missense_Mutation_p.R442C	NM_020816	NP_065867	Q9P2E2	KIF17_HUMAN	kinesin family member 17 isoform a	442	Potential.				microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			ovary(3)|skin(1)	4		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)														---	---	---	---
SH2D5	400745	broad.mit.edu	37	1	21048381	21048381	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:21048381G>A	uc001bdt.1	-	9	1549	c.924C>T	c.(922-924)TAC>TAT	p.Y308Y	SH2D5_uc009vpy.1_Silent_p.Y392Y|SH2D5_uc001bdu.1_RNA	NM_001103160	NP_001096630	Q6ZV89	SH2D5_HUMAN	SH2 domain containing 5 isoform 2	308	SH2.										0		Colorectal(325;3.46e-05)|all_lung(284;5.32e-05)|Lung NSC(340;5.51e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|COAD - Colon adenocarcinoma(152;1.17e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000142)|GBM - Glioblastoma multiforme(114;0.000465)|Kidney(64;0.000476)|STAD - Stomach adenocarcinoma(196;0.00303)|KIRC - Kidney renal clear cell carcinoma(64;0.00634)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)														---	---	---	---
EPHA8	2046	broad.mit.edu	37	1	22927816	22927816	+	Missense_Mutation	SNP	G	A	A	rs141279306		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:22927816G>A	uc001bfx.1	+	16	2878	c.2753G>A	c.(2752-2754)CGG>CAG	p.R918Q		NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	918	Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)														---	---	---	---
EPHB2	2048	broad.mit.edu	37	1	23233308	23233308	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:23233308G>A	uc009vqj.1	+	11	2139	c.1994G>A	c.(1993-1995)CGG>CAG	p.R665Q	EPHB2_uc001bge.2_Missense_Mutation_p.R666Q|EPHB2_uc001bgf.2_Missense_Mutation_p.R665Q|EPHB2_uc010odu.1_Missense_Mutation_p.R607Q	NM_017449	NP_059145	P29323	EPHB2_HUMAN	ephrin receptor EphB2 isoform 1 precursor	665	Cytoplasmic (Potential).|Protein kinase.				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			ovary(3)|lung(1)|pancreas(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)										Hereditary_Prostate_Cancer				---	---	---	---
MDS2	259283	broad.mit.edu	37	1	23954331	23954331	+	Intron	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:23954331G>A	uc001bhi.3	+						MDS2_uc001bhj.3_RNA					Homo sapiens MDS2 gene.											ovary(2)	2								T	ETV6	MDS								---	---	---	---
RHD	6007	broad.mit.edu	37	1	25611170	25611170	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:25611170G>A	uc001bjz.2	+	2	313	c.255G>A	c.(253-255)GCG>GCA	p.A85A	RHD_uc010oep.1_Silent_p.A85A|RHD_uc001bkc.2_Silent_p.A85A|RHD_uc009vrm.2_5'UTR|RHD_uc001bka.2_Silent_p.A85A|RHD_uc001bkb.2_Silent_p.A85A|RHD_uc009vrn.2_Silent_p.A85A|RHD_uc009vro.2_Silent_p.A85A|RHD_uc009vrp.2_Silent_p.A85A	NM_016124	NP_057208	Q02161	RHD_HUMAN	Rh blood group D antigen isoform 1	85	Helical; (Potential).					integral to plasma membrane				breast(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;7.39e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;6.43e-07)|STAD - Stomach adenocarcinoma(196;0.000332)|BRCA - Breast invasive adenocarcinoma(304;0.000438)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.000908)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)														---	---	---	---
MAP3K6	9064	broad.mit.edu	37	1	27682908	27682908	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:27682908C>T	uc001bny.1	-	26	3857	c.3608G>A	c.(3607-3609)CGG>CAG	p.R1203Q	MAP3K6_uc009vsw.1_Missense_Mutation_p.R1195Q	NM_004672	NP_004663	O95382	M3K6_HUMAN	mitogen-activated protein kinase kinase kinase	1203	Potential.				activation of JUN kinase activity		ATP binding|magnesium ion binding|MAP kinase kinase kinase activity			breast(4)|lung(3)|ovary(1)|central_nervous_system(1)	9		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.69e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00132)|KIRC - Kidney renal clear cell carcinoma(1967;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)														---	---	---	---
PPP1R8	5511	broad.mit.edu	37	1	28176659	28176659	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:28176659G>A	uc001bov.1	+	7	812	c.758G>A	c.(757-759)CGC>CAC	p.R253H	PPP1R8_uc001bow.1_Missense_Mutation_p.R111H|PPP1R8_uc001box.1_Missense_Mutation_p.R29H|PPP1R8_uc009vtc.1_RNA|PPP1R8_uc009vtd.1_RNA	NM_014110	NP_054829	Q12972	PP1R8_HUMAN	protein phosphatase 1 regulatory inhibitor	253					mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|RNA splicing|transcription, DNA-dependent	cytoplasm|nuclear speck|spliceosomal complex	DNA binding|endonuclease activity|protein binding|protein serine/threonine phosphatase inhibitor activity|ribonuclease E activity|RNA binding				0		Colorectal(325;3.46e-05)|all_lung(284;0.000129)|Lung NSC(340;0.000259)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;2.76e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00248)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
PTAFR	5724	broad.mit.edu	37	1	28476914	28476914	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:28476914G>T	uc001bpl.2	-	2	746	c.619C>A	c.(619-621)CTG>ATG	p.L207M	PTAFR_uc001bpm.3_Missense_Mutation_p.L207M|PTAFR_uc009vte.2_Missense_Mutation_p.L207M	NM_000952	NP_000943	P25105	PTAFR_HUMAN	platelet-activating factor receptor	207	Cytoplasmic (Potential).				chemotaxis|inflammatory response|interferon-gamma-mediated signaling pathway|phosphatidylinositol-mediated signaling	integral to plasma membrane|nucleus	phospholipid binding|platelet activating factor receptor activity				0		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00715)|all_lung(284;0.00732)|Breast(348;0.0174)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0557)		UCEC - Uterine corpus endometrioid carcinoma (279;0.215)|OV - Ovarian serous cystadenocarcinoma(117;6e-22)|Colorectal(126;3.04e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00279)|BRCA - Breast invasive adenocarcinoma(304;0.00595)|STAD - Stomach adenocarcinoma(196;0.00678)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
PTPRU	10076	broad.mit.edu	37	1	29644308	29644308	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:29644308G>A	uc001bru.2	+	26	3702	c.3592G>A	c.(3592-3594)GCC>ACC	p.A1198T	PTPRU_uc001brv.2_Missense_Mutation_p.A1194T|PTPRU_uc001brw.2_Missense_Mutation_p.A1188T|PTPRU_uc009vtq.2_Missense_Mutation_p.A1194T|PTPRU_uc009vtr.2_Missense_Mutation_p.A1185T|PTPRU_uc001brx.2_5'Flank	NM_005704	NP_005695	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	1198	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(3)|ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	7		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)														---	---	---	---
CSMD2	114784	broad.mit.edu	37	1	34046346	34046346	+	Intron	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:34046346C>A	uc001bxn.1	-						CSMD2_uc001bxm.1_Intron	NM_052896	NP_443128			CUB and Sushi multiple domains 2							integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)																---	---	---	---
CSMD2	114784	broad.mit.edu	37	1	34088992	34088992	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:34088992T>C	uc001bxn.1	-	36	5609	c.5580A>G	c.(5578-5580)GTA>GTG	p.V1860V	CSMD2_uc001bxm.1_Silent_p.V1900V|CSMD2_uc001bxo.1_Silent_p.V773V	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1860	CUB 11.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)																---	---	---	---
ZMYM6	9204	broad.mit.edu	37	1	35453279	35453279	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:35453279G>A	uc001byh.2	-	16	3632	c.3404C>T	c.(3403-3405)ACT>ATT	p.T1135I	uc001byd.3_5'Flank|uc001bye.2_5'Flank|ZMYM6_uc001byf.1_Intron|ZMYM6_uc010oht.1_Missense_Mutation_p.T1038I	NM_007167	NP_009098	O95789	ZMYM6_HUMAN	zinc finger protein 258	1135					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)																---	---	---	---
ZMYM6	9204	broad.mit.edu	37	1	35474381	35474381	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:35474381A>G	uc001byh.2	-	11	1865	c.1637T>C	c.(1636-1638)ATG>ACG	p.M546T	ZMYM6_uc001byf.1_Missense_Mutation_p.M546T|ZMYM6_uc010oht.1_Missense_Mutation_p.M449T|ZMYM6_uc009vup.2_Missense_Mutation_p.M352T|ZMYM6_uc009vuq.1_Missense_Mutation_p.M546T|ZMYM6_uc009vur.1_Missense_Mutation_p.M352T	NM_007167	NP_009098	O95789	ZMYM6_HUMAN	zinc finger protein 258	546	MYM-type 8.				multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)																---	---	---	---
HPCAL4	51440	broad.mit.edu	37	1	40150278	40150278	+	5'UTR	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:40150278C>T	uc001cdr.2	-	2					HPCAL4_uc010oix.1_5'UTR	NM_016257	NP_057341			hippocalcin-like protein 4						central nervous system development	intracellular	calcium ion binding			central_nervous_system(1)	1	all_cancers(7;4.65e-13)|Lung NSC(20;2.88e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)															---	---	---	---
HIVEP3	59269	broad.mit.edu	37	1	42049803	42049803	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:42049803G>A	uc001cgz.3	-	4	1879	c.666C>T	c.(664-666)TGC>TGT	p.C222C	HIVEP3_uc001cha.3_Silent_p.C222C|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	222	C2H2-type 2.|No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).|ZAS1.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)																---	---	---	---
YBX1	4904	broad.mit.edu	37	1	43162317	43162317	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:43162317C>T	uc001chs.2	+	5	530	c.359C>T	c.(358-360)GCG>GTG	p.A120V		NM_004559	NP_004550	P67809	YBOX1_HUMAN	nuclease sensitive element binding protein 1	120	CSD.			A -> E (in Ref. 2; AAA61308).	CRD-mediated mRNA stabilization|negative regulation of transcription, DNA-dependent|nuclear mRNA splicing, via spliceosome|positive regulation of cell division|transcription from RNA polymerase II promoter	CRD-mediated mRNA stability complex|extracellular region|histone pre-mRNA 3'end processing complex|nucleoplasm|stress granule|U12-type spliceosomal complex	double-stranded DNA binding|protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			ovary(4)|upper_aerodigestive_tract(1)	5	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)																---	---	---	---
LEPRE1	64175	broad.mit.edu	37	1	43215906	43215906	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:43215906C>T	uc001chv.2	-	11	1784	c.1671G>A	c.(1669-1671)ACG>ACA	p.T557T	LEPRE1_uc001chw.2_Silent_p.T557T|LEPRE1_uc001chx.3_Silent_p.T557T	NM_022356	NP_071751	Q32P28	P3H1_HUMAN	leprecan 1 isoform 1	557					negative regulation of cell proliferation	endoplasmic reticulum|proteinaceous extracellular matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			ovary(3)|lung(1)	4	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)			L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)													---	---	---	---
DPH2	1802	broad.mit.edu	37	1	44436283	44436283	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:44436283C>T	uc001ckz.2	+	2	358	c.163C>T	c.(163-165)CCT>TCT	p.P55S	DPH2_uc001cla.2_Missense_Mutation_p.P55S|DPH2_uc010okk.1_5'UTR|DPH2_uc001clb.2_5'UTR	NM_001384	NP_001375	Q9BQC3	DPH2_HUMAN	diphthamide biosynthesis protein 2 isoform a	55					peptidyl-diphthamide biosynthetic process from peptidyl-histidine	cytoplasm				ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)																---	---	---	---
DMAP1	55929	broad.mit.edu	37	1	44685744	44685744	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:44685744C>T	uc001clq.1	+	10	1187	c.1107C>T	c.(1105-1107)AGC>AGT	p.S369S	DMAP1_uc001clr.1_Silent_p.S369S|DMAP1_uc001cls.1_Silent_p.S369S|DMAP1_uc010oku.1_Silent_p.S359S	NM_001034024	NP_001029196	Q9NPF5	DMAP1_HUMAN	DNA methyltransferase 1 associated protein 1	369					DNA methylation|histone H2A acetylation|histone H4 acetylation|negative regulation of transcription, DNA-dependent|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex	DNA binding|protein binding				0	Acute lymphoblastic leukemia(166;0.155)															OREG0013438	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
KIF2C	11004	broad.mit.edu	37	1	45216216	45216216	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:45216216G>A	uc001cmg.3	+	5	534	c.419G>A	c.(418-420)CGC>CAC	p.R140H	KIF2C_uc010olb.1_Missense_Mutation_p.R140H|KIF2C_uc010olc.1_Missense_Mutation_p.R27H|KIF2C_uc001cmh.3_Missense_Mutation_p.R86H	NM_006845	NP_006836	Q99661	KIF2C_HUMAN	kinesin family member 2C	140	Globular (Potential).				blood coagulation|cell division|cell proliferation|chromosome segregation|establishment or maintenance of microtubule cytoskeleton polarity|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|kinesin complex|microtubule|nucleus	ATP binding|centromeric DNA binding|microtubule motor activity|microtubule plus-end binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)																	---	---	---	---
PTCH2	8643	broad.mit.edu	37	1	45293142	45293142	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:45293142G>A	uc010olf.1	-	15	2315	c.2303C>T	c.(2302-2304)GCG>GTG	p.A768V	PTCH2_uc010olg.1_Missense_Mutation_p.A466V	NM_003738	NP_003729	Q9Y6C5	PTC2_HUMAN	patched 2	768	Extracellular (Potential).				protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity			lung(6)|breast(6)|central_nervous_system(3)|skin(2)|ovary(1)	18	Acute lymphoblastic leukemia(166;0.155)													Basal_Cell_Nevus_syndrome				---	---	---	---
HECTD3	79654	broad.mit.edu	37	1	45476257	45476257	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:45476257T>C	uc009vxk.2	-	2	589	c.491A>G	c.(490-492)CAG>CGG	p.Q164R	HECTD3_uc001cmy.3_5'Flank|HECTD3_uc010olh.1_Intron|UROD_uc010oli.1_5'Flank|UROD_uc001cna.1_5'Flank|UROD_uc001cnb.1_5'Flank|UROD_uc010olj.1_5'Flank|UROD_uc001cnc.1_5'Flank	NM_024602	NP_078878	Q5T447	HECD3_HUMAN	HECT domain containing 3	164					proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	ubiquitin-protein ligase activity				0	Acute lymphoblastic leukemia(166;0.155)																	---	---	---	---
FAF1	11124	broad.mit.edu	37	1	51323599	51323599	+	Splice_Site	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:51323599A>G	uc009vyx.1	-	3	177	c.114_splice	c.e3+1	p.V38_splice	FAF1_uc009vyw.1_Splice_Site|FAF1_uc001cse.1_Splice_Site_p.V38_splice	NM_007051	NP_008982			FAS-associated factor 1						apoptosis|cytoplasmic sequestering of NF-kappaB|positive regulation of apoptosis|positive regulation of protein complex assembly|proteasomal ubiquitin-dependent protein catabolic process|regulation of protein catabolic process	CD95 death-inducing signaling complex|cytosol|perinuclear region of cytoplasm	heat shock protein binding|NF-kappaB binding|protein kinase binding|protein kinase regulator activity	p.0?(2)		ovary(1)|pancreas(1)	2				GBM - Glioblastoma multiforme(3;3.18e-11)|all cancers(3;0.00526)														---	---	---	---
PODN	127435	broad.mit.edu	37	1	53546514	53546514	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:53546514G>A	uc001cuv.2	+	9	1778	c.1771G>A	c.(1771-1773)GAC>AAC	p.D591N	PODN_uc001cuw.2_Missense_Mutation_p.D572N|PODN_uc010onr.1_Missense_Mutation_p.D572N|PODN_uc010ons.1_Missense_Mutation_p.D449N	NM_153703	NP_714914	Q7Z5L7	PODN_HUMAN	podocan	543	LRR 18.				negative regulation of cell migration|negative regulation of cell proliferation	cytoplasm|extracellular space|proteinaceous extracellular matrix	collagen binding			ovary(1)|pancreas(1)	2																		---	---	---	---
DMRTB1	63948	broad.mit.edu	37	1	53925671	53925671	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:53925671G>A	uc001cvq.1	+	1	600	c.545G>A	c.(544-546)CGG>CAG	p.R182Q		NM_033067	NP_149056	Q96MA1	DMRTB_HUMAN	DMRT-like family B with proline-rich C-terminal,	182	Pro-rich.				sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2																		---	---	---	---
TMEM59	9528	broad.mit.edu	37	1	54506485	54506485	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:54506485C>T	uc001cwp.2	-	6	901	c.651G>A	c.(649-651)GCG>GCA	p.A217A	TMEM59_uc001cwn.2_Silent_p.A81A|TMEM59_uc001cwo.2_Silent_p.A80A|TMEM59_uc001cwq.2_Silent_p.A218A|TMEM59_uc001cwr.2_Silent_p.A150A|TMEM59_uc001cws.1_Silent_p.A229A	NM_004872	NP_004863	Q9BXS4	TMM59_HUMAN	thymic dendritic cell-derived factor 1	217	Extracellular (Potential).					Golgi membrane|integral to membrane					0																		---	---	---	---
TMEM59	9528	broad.mit.edu	37	1	54509067	54509067	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:54509067G>A	uc001cwp.2	-	4	772	c.522C>T	c.(520-522)GAC>GAT	p.D174D	TMEM59_uc001cwn.2_Silent_p.D37D|TMEM59_uc001cwo.2_Silent_p.D37D|TMEM59_uc001cwq.2_Silent_p.D174D|TMEM59_uc001cwr.2_Silent_p.D107D|TMEM59_uc001cws.1_Silent_p.D185D	NM_004872	NP_004863	Q9BXS4	TMM59_HUMAN	thymic dendritic cell-derived factor 1	174	Extracellular (Potential).					Golgi membrane|integral to membrane					0																		---	---	---	---
JUN	3725	broad.mit.edu	37	1	59248342	59248342	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:59248342G>T	uc001cze.2	-	1	1444	c.401C>A	c.(400-402)GCG>GAG	p.A134E	uc001czf.2_5'Flank|uc010oop.1_5'Flank	NM_002228	NP_002219	P05412	JUN_HUMAN	jun oncogene	134					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation by host of viral transcription|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|SMAD protein import into nucleus|SMAD protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway		R-SMAD binding|Rho GTPase activator activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription coactivator activity|transcription factor binding|transcription regulatory region DNA binding				0	all_cancers(7;8.55e-07)				Arsenic trioxide(DB01169)|Irbesartan(DB01029)|Vinblastine(DB00570)			A		sarcoma								---	---	---	---
KANK4	163782	broad.mit.edu	37	1	62740642	62740642	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:62740642T>C	uc001dah.3	-	3	511	c.134A>G	c.(133-135)GAC>GGC	p.D45G	KANK4_uc001dai.3_Intron|KANK4_uc001dag.3_5'Flank	NM_181712	NP_859063	Q5T7N3	KANK4_HUMAN	ankyrin repeat domain 38	45										ovary(3)|skin(2)|lung(1)	6																		---	---	---	---
FOXD3	27022	broad.mit.edu	37	1	63789164	63789164	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:63789164G>A	uc001dax.2	+	1	435	c.435G>A	c.(433-435)TCG>TCA	p.S145S		NM_012183	NP_036315	Q9UJU5	FOXD3_HUMAN	forkhead box D3	145	Fork-head.				axon extension involved in axon guidance|branching involved in ureteric bud morphogenesis|cartilage development|embryonic placenta development|enteric nervous system development|iridophore differentiation|kidney development|lateral line nerve glial cell development|melanocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development|trophectodermal cell differentiation	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0																		---	---	---	---
EFCAB7	84455	broad.mit.edu	37	1	63991248	63991248	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:63991248C>T	uc001dbf.2	+	2	299	c.5C>T	c.(4-6)GCG>GTG	p.A2V	ITGB3BP_uc001dba.1_5'Flank|ITGB3BP_uc001dbb.1_5'Flank|ITGB3BP_uc001dbc.1_5'Flank|ITGB3BP_uc001dbd.1_5'Flank|ITGB3BP_uc009wak.1_5'Flank	NM_032437	NP_115813	A8K855	EFCB7_HUMAN	EF-hand calcium binding domain 7	2							calcium ion binding				0																		---	---	---	---
ROR1	4919	broad.mit.edu	37	1	64608333	64608333	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:64608333G>A	uc001dbj.2	+	7	1573	c.1174G>A	c.(1174-1176)GAT>AAT	p.D392N	ROR1_uc001dbi.3_Missense_Mutation_p.G392S|uc001dbl.2_Intron	NM_005012	NP_005003	Q01973	ROR1_HUMAN	receptor tyrosine kinase-like orphan receptor 1	392	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			ovary(6)|large_intestine(3)|breast(3)|stomach(2)|lung(2)|central_nervous_system(1)|skin(1)|kidney(1)	19																		---	---	---	---
RAVER2	55225	broad.mit.edu	37	1	65243369	65243369	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:65243369C>T	uc001dbs.1	+	3	458	c.380C>T	c.(379-381)TCT>TTT	p.S127F	RAVER2_uc001dbt.1_Missense_Mutation_p.S6F|RAVER2_uc010opb.1_Missense_Mutation_p.S6F	NM_018211	NP_060681	Q9HCJ3	RAVR2_HUMAN	ribonucleoprotein, PTB-binding 2	127	RRM 1.					cytoplasm|nucleus	nucleotide binding|RNA binding			large_intestine(1)	1																		---	---	---	---
SLC44A5	204962	broad.mit.edu	37	1	75681465	75681465	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:75681465A>C	uc001dgu.2	-	19	1846	c.1702T>G	c.(1702-1704)TTT>GTT	p.F568V	SLC44A5_uc001dgt.2_Missense_Mutation_p.F568V|SLC44A5_uc001dgs.2_Missense_Mutation_p.F526V|SLC44A5_uc001dgr.2_Missense_Mutation_p.F526V|SLC44A5_uc010oqz.1_Missense_Mutation_p.F607V|SLC44A5_uc010ora.1_Missense_Mutation_p.F562V|SLC44A5_uc010orb.1_Missense_Mutation_p.F438V	NM_152697	NP_689910	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5 isoform A	568	Cytoplasmic (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			ovary(2)|skin(2)	4																		---	---	---	---
RABGGTB	5876	broad.mit.edu	37	1	76253656	76253656	+	Intron	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:76253656T>C	uc001dgy.1	+						RABGGTB_uc009wbt.1_Intron|RABGGTB_uc001dha.1_Intron|SNORD45A_uc009wbu.1_RNA|SNORD45B_uc009wbv.1_5'Flank	NM_004582	NP_004573			RAB geranylgeranyltransferase, beta subunit						protein modification process|visual perception		metal ion binding|protein binding|Rab geranylgeranyltransferase activity			ovary(1)	1																		---	---	---	---
FUBP1	8880	broad.mit.edu	37	1	78426155	78426155	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:78426155G>T	uc001dii.2	-	15	1459	c.1370C>A	c.(1369-1371)CCT>CAT	p.P457H	FUBP1_uc001dih.3_RNA|FUBP1_uc010orm.1_Missense_Mutation_p.P478H	NM_003902	NP_003893	Q96AE4	FUBP1_HUMAN	far upstream element-binding protein	457	Pro-rich.				transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(2)|lung(1)	3																		---	---	---	---
FUBP1	8880	broad.mit.edu	37	1	78435709	78435709	+	Intron	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:78435709A>G	uc001dii.2	-						FUBP1_uc001dih.3_Intron|FUBP1_uc010orm.1_Intron	NM_003902	NP_003893			far upstream element-binding protein						transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(2)|lung(1)	3																		---	---	---	---
CCBL2	56267	broad.mit.edu	37	1	89426867	89426867	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:89426867T>A	uc001dmp.2	-	8	1147	c.770A>T	c.(769-771)AAT>ATT	p.N257I	CCBL2_uc001dmq.2_Missense_Mutation_p.N223I|CCBL2_uc001dmr.2_Missense_Mutation_p.N93I	NM_001008661	NP_001008661	Q6YP21	KAT3_HUMAN	kynurenine aminotransferase III isoform 1	257					biosynthetic process|kynurenine metabolic process|tryptophan catabolic process		cysteine-S-conjugate beta-lyase activity|kynurenine-glyoxylate transaminase activity|kynurenine-oxoglutarate transaminase activity|pyridoxal phosphate binding			ovary(1)	1		Lung NSC(277;0.123)		all cancers(265;0.0117)|Epithelial(280;0.0341)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)													---	---	---	---
RBMXL1	494115	broad.mit.edu	37	1	89449327	89449327	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:89449327G>A	uc009wcx.2	-	3	899	c.183C>T	c.(181-183)GAC>GAT	p.D61D	CCBL2_uc001dmp.2_Intron|CCBL2_uc001dmq.2_Intron|CCBL2_uc001dmr.2_Intron|RBMXL1_uc001dms.2_Silent_p.D61D	NM_001162536	NP_001156008	Q96E39	RBMXL_HUMAN	RNA binding motif protein, X-linked-like 1	61	RRM.						nucleotide binding|RNA binding				0																OREG0013593	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
GBP3	2635	broad.mit.edu	37	1	89478880	89478880	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:89478880C>T	uc001dmt.2	-	6	1061	c.856G>A	c.(856-858)GTC>ATC	p.V286I	GBP3_uc010oss.1_Missense_Mutation_p.V207I|GBP3_uc001dmu.2_Missense_Mutation_p.V152I|GBP3_uc001dmv.2_RNA	NM_018284	NP_060754	Q9H0R5	GBP3_HUMAN	guanylate binding protein 3	286						integral to membrane	GTP binding|GTPase activity			ovary(1)|pancreas(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0103)|Epithelial(280;0.0293)														---	---	---	---
AMY2A	279	broad.mit.edu	37	1	104160223	104160223	+	Missense_Mutation	SNP	G	A	A	rs148925092		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:104160223G>A	uc001dut.2	+	1	225	c.161G>A	c.(160-162)GGG>GAG	p.G54E	AMY2A_uc010ouq.1_Missense_Mutation_p.G54E	NM_000699	NP_000690	P04746	AMYP_HUMAN	pancreatic amylase alpha 2A precursor	54					carbohydrate catabolic process|polysaccharide digestion	extracellular space	alpha-amylase activity|calcium ion binding|chloride ion binding			ovary(1)|skin(1)	2		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0654)|all cancers(265;0.0808)|Epithelial(280;0.0921)|Lung(183;0.111)	Acarbose(DB00284)|Bentiromide(DB00522)|Icodextrin(DB00702)|Miglitol(DB00491)|Pancrelipase(DB00085)													---	---	---	---
CELSR2	1952	broad.mit.edu	37	1	109813153	109813153	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:109813153C>T	uc001dxa.3	+	24	7475	c.7414C>T	c.(7414-7416)CGC>TGC	p.R2472C		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	2472	Cytoplasmic (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)														---	---	---	---
GSTM4	2948	broad.mit.edu	37	1	110199841	110199841	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:110199841T>C	uc001dyf.2	+	3	431	c.117T>C	c.(115-117)CCT>CCC	p.P39P	GSTM4_uc009wfi.2_3'UTR|GSTM4_uc001dyg.2_5'UTR|GSTM4_uc009wfj.2_Silent_p.P39P|GSTM4_uc001dyh.2_Silent_p.P39P|GSTM2_uc001dyi.2_Intron	NM_000850	NP_000841	Q03013	GSTM4_HUMAN	glutathione S-transferase mu 4 isoform 1	39	GST N-terminal.				xenobiotic metabolic process	endoplasmic reticulum membrane	glutathione transferase activity				0		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		all cancers(265;0.0123)|Colorectal(144;0.0129)|Epithelial(280;0.0147)|Lung(183;0.0422)|COAD - Colon adenocarcinoma(174;0.0471)|LUSC - Lung squamous cell carcinoma(189;0.227)	Glutathione(DB00143)													---	---	---	---
KCNA2	3737	broad.mit.edu	37	1	111147202	111147202	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:111147202T>A	uc001dzu.2	-	2	699	c.203A>T	c.(202-204)TAC>TTC	p.Y68F	KCNA2_uc009wfv.1_Missense_Mutation_p.Y68F|KCNA2_uc009wfw.2_Missense_Mutation_p.Y68F	NM_004974	NP_004965	P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related	68						juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(1)	1		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)														---	---	---	---
KCNA3	3738	broad.mit.edu	37	1	111216300	111216300	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:111216300A>G	uc001dzv.1	-	1	1356	c.1132T>C	c.(1132-1134)TCG>CCG	p.S378P		NM_002232	NP_002223	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related	378	Helical; Voltage-sensor; Name=Segment S4; (Potential).					voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(4)|pancreas(1)	5		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)														---	---	---	---
KCNA3	3738	broad.mit.edu	37	1	111216362	111216362	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:111216362G>A	uc001dzv.1	-	1	1294	c.1070C>T	c.(1069-1071)GCC>GTC	p.A357V		NM_002232	NP_002223	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related	357						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(4)|pancreas(1)	5		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)														---	---	---	---
DRAM2	128338	broad.mit.edu	37	1	111667451	111667451	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:111667451T>C	uc001ead.3	-	5	509	c.252A>G	c.(250-252)GAA>GAG	p.E84E	DRAM2_uc001eae.3_Silent_p.E84E|DRAM2_uc009wfy.2_RNA|DRAM2_uc001eaf.3_Intron	NM_178454	NP_848549	Q6UX65	DRAM2_HUMAN	transmembrane protein 77	84					apoptosis|induction of apoptosis	Golgi apparatus|integral to membrane|lysosomal membrane					0																		---	---	---	---
RSBN1	54665	broad.mit.edu	37	1	114308955	114308955	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:114308955A>G	uc001edq.2	-	7	2092	c.2056T>C	c.(2056-2058)TTC>CTC	p.F686L	RSBN1_uc001edr.2_RNA	NM_018364	NP_060834	Q5VWQ0	RSBN1_HUMAN	round spermatid basic protein 1	686						nucleus				ovary(1)	1	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)														---	---	---	---
DCLRE1B	64858	broad.mit.edu	37	1	114454003	114454003	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:114454003C>T	uc001eeg.2	+	4	960	c.789C>T	c.(787-789)AGC>AGT	p.S263S	DCLRE1B_uc001eeh.2_Silent_p.S137S|DCLRE1B_uc001eei.2_Silent_p.S137S	NM_022836	NP_073747	Q9H816	DCR1B_HUMAN	DNA cross-link repair 1B (PSO2 homolog, S.	263					cell cycle checkpoint|DNA repair|protection from non-homologous end joining at telomere|telomeric 3' overhang formation|telomeric loop formation	centrosome|chromosome, telomeric region|nucleus	5'-3' exonuclease activity|protein binding				0	Lung SC(450;0.184)	all_cancers(81;1.46e-05)|all_epithelial(167;2.42e-05)|all_lung(203;0.000353)|Lung NSC(69;0.000518)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)									Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					---	---	---	---
HIPK1	204851	broad.mit.edu	37	1	114516066	114516066	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:114516066C>T	uc001eem.2	+	16	3726	c.3565C>T	c.(3565-3567)CGA>TGA	p.R1189*	HIPK1_uc001een.2_Nonsense_Mutation_p.R1189*|HIPK1_uc001eeo.2_Nonsense_Mutation_p.R815*|HIPK1_uc001eep.2_Nonsense_Mutation_p.R795*|HIPK1_uc001eeq.2_Nonsense_Mutation_p.R481*	NM_198268	NP_938009	Q86Z02	HIPK1_HUMAN	homeodomain-interacting protein kinase 1 isoform	1189					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(4)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)														---	---	---	---
HMGCS2	3158	broad.mit.edu	37	1	120298076	120298076	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:120298076G>A	uc001eid.2	-	6	1212	c.1161C>T	c.(1159-1161)TAC>TAT	p.Y387Y	HMGCS2_uc010oxj.1_Silent_p.Y345Y|HMGCS2_uc001eie.2_Silent_p.Y295Y	NM_005518	NP_005509	P54868	HMCS2_HUMAN	hydroxymethylglutaryl-CoA synthase 2 isoform 1	387					acetoacetic acid biosynthetic process|cholesterol biosynthetic process|isoprenoid biosynthetic process|ketone body biosynthetic process	mitochondrial matrix	hydroxymethylglutaryl-CoA synthase activity			ovary(2)	2	all_cancers(5;6.38e-10)|all_epithelial(5;1.1e-10)|Melanoma(3;1.93e-05)|Breast(55;0.218)|all_neural(166;0.219)	all_lung(203;1.29e-06)|Lung NSC(69;9.35e-06)|all_epithelial(167;0.00124)		Lung(183;0.0112)|LUSC - Lung squamous cell carcinoma(189;0.0595)														---	---	---	---
PLEKHO1	51177	broad.mit.edu	37	1	150131589	150131589	+	Silent	SNP	C	T	T	rs148396210		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:150131589C>T	uc001ett.2	+	6	1379	c.1101C>T	c.(1099-1101)AGC>AGT	p.S367S	PLEKHO1_uc001etr.2_Silent_p.S195S|PLEKHO1_uc001ets.2_Silent_p.S184S|PLEKHO1_uc001etu.2_Silent_p.S195S	NM_016274	NP_057358	Q53GL0	PKHO1_HUMAN	pleckstrin homology domain containing, family O	367	Negative regulator of AP-1 activity.					cytoplasm|nucleus|plasma membrane				lung(1)	1	Lung NSC(24;7.78e-28)|Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)															---	---	---	---
ADAMTSL4	54507	broad.mit.edu	37	1	150528719	150528719	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:150528719C>T	uc001eux.2	+	9	1689	c.1453C>T	c.(1453-1455)CGC>TGC	p.R485C	ADAMTSL4_uc001euw.2_Missense_Mutation_p.R485C|ADAMTSL4_uc009wlw.2_Missense_Mutation_p.R508C|ADAMTSL4_uc010pcg.1_Missense_Mutation_p.R508C|ADAMTSL4_uc009wlx.2_5'Flank	NM_019032	NP_061905	Q6UY14	ATL4_HUMAN	thrombospondin repeat containing 1 isoform 1	485					apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			ovary(1)|skin(1)	2	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)															---	---	---	---
PIP5K1A	8394	broad.mit.edu	37	1	151219440	151219440	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:151219440A>G	uc001exj.2	+	15	2137	c.1685A>G	c.(1684-1686)CAT>CGT	p.H562R	PIP5K1A_uc001exi.2_Missense_Mutation_p.H549R|PIP5K1A_uc010pcu.1_Missense_Mutation_p.H522R|PIP5K1A_uc001exk.2_Missense_Mutation_p.H500R|PIP5K1A_uc010pcv.1_Missense_Mutation_p.I227V	NM_001135638	NP_001129110	Q99755	PI51A_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	562					phospholipid biosynthetic process|signal transduction	endomembrane system|Golgi stack|lamellipodium|nuclear speck	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|kinase binding			ovary(1)|central_nervous_system(1)|skin(1)	3	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.181)															---	---	---	---
TUFT1	7286	broad.mit.edu	37	1	151538676	151538676	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:151538676C>A	uc001eyl.2	+	6	514	c.452C>A	c.(451-453)CCC>CAC	p.P151H	TUFT1_uc001eym.2_Missense_Mutation_p.P126H|TUFT1_uc010pdf.1_Missense_Mutation_p.P170H|TUFT1_uc010pdg.1_Missense_Mutation_p.P99H	NM_020127	NP_064512	Q9NNX1	TUFT1_HUMAN	tuftelin 1 isoform 1	151					bone mineralization|odontogenesis	cytoplasm|extracellular region	structural constituent of tooth enamel				0	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)															---	---	---	---
FLG	2312	broad.mit.edu	37	1	152286203	152286203	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:152286203C>T	uc001ezu.1	-	3	1195	c.1159G>A	c.(1159-1161)GGC>AGC	p.G387S	uc001ezv.2_RNA	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	387	Ser-rich.|Filaggrin 2.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)											Ichthyosis				---	---	---	---
S100A3	6274	broad.mit.edu	37	1	153520175	153520175	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:153520175G>A	uc001fca.1	-	3	372	c.289C>T	c.(289-291)CCC>TCC	p.P97S	S100A4_uc001fby.2_5'Flank|S100A4_uc001fbz.2_5'Flank|uc009wog.1_Intron	NM_002960	NP_002951	P33764	S10A3_HUMAN	S100 calcium binding protein A3	97							calcium ion binding|protein binding				0	all_lung(78;5.98e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)															---	---	---	---
S100A16	140576	broad.mit.edu	37	1	153580513	153580513	+	Missense_Mutation	SNP	G	A	A	rs142272783		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:153580513G>A	uc001fcc.2	-	2	248	c.115C>T	c.(115-117)CGC>TGC	p.R39C	S100A16_uc001fcd.1_Missense_Mutation_p.R39C	NM_080388	NP_525127	Q96FQ6	S10AG_HUMAN	S100 calcium binding protein A16	39	EF-hand 1.					cytosol|nucleolus	calcium ion binding|protein homodimerization activity				0	all_lung(78;1.84e-32)|Lung NSC(65;6.67e-31)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)															---	---	---	---
INTS3	65123	broad.mit.edu	37	1	153732081	153732081	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:153732081T>C	uc009wom.2	+	12	1450	c.1229T>C	c.(1228-1230)ATG>ACG	p.M410T	INTS3_uc001fct.2_Missense_Mutation_p.M410T|INTS3_uc001fcu.2_Missense_Mutation_p.M102T|INTS3_uc001fcv.2_Missense_Mutation_p.M204T|INTS3_uc010peb.1_Missense_Mutation_p.M204T|INTS3_uc001fcw.2_5'UTR|INTS3_uc010pec.1_Intron	NM_023015	NP_075391	Q68E01	INT3_HUMAN	integrator complex subunit 3	411					DNA repair|G2/M transition checkpoint|response to ionizing radiation|snRNA processing	integrator complex|SOSS complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)															---	---	---	---
ATP8B2	57198	broad.mit.edu	37	1	154302881	154302881	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:154302881G>T	uc001fey.1	+	2	287	c.98G>T	c.(97-99)AGG>ATG	p.R33M	ATP8B2_uc001few.2_Missense_Mutation_p.R14M|ATP8B2_uc001fex.2_Missense_Mutation_p.R47M	NM_001005855	NP_001005855	P98198	AT8B2_HUMAN	ATPase, class I, type 8B, member 2 isoform b	33	Cytoplasmic (Potential).				ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(1)|skin(1)	2	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)															---	---	---	---
PBXIP1	57326	broad.mit.edu	37	1	154924376	154924376	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:154924376C>A	uc001ffr.2	-	3	132	c.73G>T	c.(73-75)GGC>TGC	p.G25C	PBXIP1_uc001ffs.2_5'UTR|PBXIP1_uc010pep.1_Intron|PBXIP1_uc009woy.1_RNA	NM_020524	NP_065385	Q96AQ6	PBIP1_HUMAN	pre-B-cell leukemia homeobox interacting protein	25					cell differentiation|multicellular organismal development|negative regulation of transcription, DNA-dependent	cytosol|microtubule|nucleus	protein binding|transcription corepressor activity			large_intestine(1)	1	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)															---	---	---	---
GBA	2629	broad.mit.edu	37	1	155209427	155209427	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:155209427T>C	uc001fjh.2	-	4	584	c.434A>G	c.(433-435)AAA>AGA	p.K145R	RAG1AP1_uc010pey.1_Intron|GBA_uc010pfw.1_Intron|GBA_uc010pfx.1_Intron|GBA_uc001fji.2_Missense_Mutation_p.K145R|GBA_uc001fjj.2_Missense_Mutation_p.K145R|GBA_uc001fjk.2_Missense_Mutation_p.K145R|GBA_uc001fjl.2_Missense_Mutation_p.K145R|GBA_uc010pfy.1_Missense_Mutation_p.K58R|GBA_uc009wqk.1_Missense_Mutation_p.K58R	NM_000157	NP_000148	P04062	GLCM_HUMAN	glucocerebrosidase precursor	145					carbohydrate metabolic process|cell death|cellular response to tumor necrosis factor|ceramide biosynthetic process|glucosylceramide catabolic process|lysosome organization|negative regulation of interleukin-6 production|negative regulation of MAP kinase activity|positive regulation of protein dephosphorylation|sphingosine biosynthetic process|termination of signal transduction	lysosomal lumen|lysosomal membrane	cation binding|glucosylceramidase activity|receptor binding			ovary(1)|skin(1)	2	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)		Alglucerase(DB00088)|Imiglucerase(DB00053)									Gaucher_disease_type_I				---	---	---	---
CLK2	1196	broad.mit.edu	37	1	155233743	155233743	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:155233743G>A	uc001fjy.2	-	12	1605	c.1315C>T	c.(1315-1317)CGG>TGG	p.R439W	RAG1AP1_uc010pey.1_Intron|SCAMP3_uc001fjs.2_5'Flank|SCAMP3_uc001fju.2_5'Flank|SCAMP3_uc001fjv.2_5'Flank|SCAMP3_uc001fjt.2_5'Flank|CLK2_uc001fjw.2_Missense_Mutation_p.R438W|CLK2_uc001fjx.2_Missense_Mutation_p.R211W|CLK2_uc009wqm.2_Missense_Mutation_p.R439W	NM_003993	NP_003984	P49760	CLK2_HUMAN	CDC-like kinase 2	439	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)										Other_conserved_DNA_damage_response_genes					---	---	---	---
CLK2	1196	broad.mit.edu	37	1	155234303	155234303	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:155234303C>A	uc001fjy.2	-	10	1392	c.1102G>T	c.(1102-1104)GGC>TGC	p.G368C	RAG1AP1_uc010pey.1_Intron|SCAMP3_uc001fjs.2_5'Flank|SCAMP3_uc001fju.2_5'Flank|SCAMP3_uc001fjv.2_5'Flank|SCAMP3_uc001fjt.2_5'Flank|CLK2_uc001fjw.2_Missense_Mutation_p.G367C|CLK2_uc001fjx.2_Missense_Mutation_p.G140C|CLK2_uc009wqm.2_Missense_Mutation_p.G368C	NM_003993	NP_003984	P49760	CLK2_HUMAN	CDC-like kinase 2	368	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)										Other_conserved_DNA_damage_response_genes					---	---	---	---
CCT3	7203	broad.mit.edu	37	1	156286984	156286984	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156286984C>A	uc001fol.1	-	10	1167	c.947G>T	c.(946-948)CGG>CTG	p.R316L	CCT3_uc001fom.1_Missense_Mutation_p.R315L|CCT3_uc001fon.1_Missense_Mutation_p.R278L|CCT3_uc010phj.1_Missense_Mutation_p.R270L|CCT3_uc010phk.1_Missense_Mutation_p.R270L|CCT3_uc010phl.1_Missense_Mutation_p.R270L	NM_005998	NP_005989	P49368	TCPG_HUMAN	chaperonin containing TCP1, subunit 3 isoform a	316					'de novo' posttranslational protein folding	cytoskeleton|cytosol|plasma membrane	ATP binding|unfolded protein binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.158)																	---	---	---	---
MRPL24	79590	broad.mit.edu	37	1	156707482	156707482	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156707482G>T	uc001fpw.1	-	5	609	c.470C>A	c.(469-471)CCC>CAC	p.P157H	MRPL24_uc001fpx.1_Missense_Mutation_p.P157H	NM_024540	NP_078816	Q96A35	RM24_HUMAN	mitochondrial ribosomal protein L24 precursor	157					translation	mitochondrion|ribosome	structural constituent of ribosome				0	all_hematologic(923;0.088)|Hepatocellular(266;0.158)																	---	---	---	---
CD1A	909	broad.mit.edu	37	1	158224528	158224528	+	Intron	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:158224528T>C	uc001frt.2	+							NM_001763	NP_001754			CD1A antigen precursor						antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)													---	---	---	---
OR10X1	128367	broad.mit.edu	37	1	158549613	158549613	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:158549613T>C	uc010pin.1	-	1	77	c.77A>G	c.(76-78)AAG>AGG	p.K26R		NM_001004477	NP_001004477	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X,	26	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)																	---	---	---	---
SPTA1	6708	broad.mit.edu	37	1	158639307	158639307	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:158639307C>T	uc001fst.1	-	14	1923	c.1724G>A	c.(1723-1725)CGT>CAT	p.R575H		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	575	Spectrin 6.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)																	---	---	---	---
PYHIN1	149628	broad.mit.edu	37	1	158911972	158911972	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:158911972A>G	uc001ftb.2	+	5	1030	c.785A>G	c.(784-786)AAA>AGA	p.K262R	PYHIN1_uc001ftc.2_Missense_Mutation_p.K253R|PYHIN1_uc001ftd.2_Missense_Mutation_p.K262R|PYHIN1_uc001fte.2_Missense_Mutation_p.K253R	NM_152501	NP_689714	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1 alpha 1	262	HIN-200.				cell cycle	nuclear speck				ovary(3)|pancreas(1)	4	all_hematologic(112;0.0378)																	---	---	---	---
OR10J3	441911	broad.mit.edu	37	1	159284045	159284045	+	Silent	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:159284045G>T	uc010piu.1	-	1	405	c.405C>A	c.(403-405)GTC>GTA	p.V135V		NM_001004467	NP_001004467	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J,	135	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_hematologic(112;0.0429)																	---	---	---	---
ITLN1	55600	broad.mit.edu	37	1	160851038	160851038	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:160851038G>T	uc001fxc.2	-	5	586	c.470C>A	c.(469-471)CCC>CAC	p.P157H		NM_017625	NP_060095	Q8WWA0	ITLN1_HUMAN	intelectin precursor	157	Fibrinogen C-terminal.				positive regulation of glucose import|positive regulation of protein phosphorylation|response to nematode|signal transduction	anchored to membrane|brush border membrane|extracellular region|membrane raft	receptor binding|sugar binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)|central_nervous_system(1)	7	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)															---	---	---	---
NR1I3	9970	broad.mit.edu	37	1	161199504	161199504	+	3'UTR	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:161199504G>A	uc001fzx.2	-	9					TOMM40L_uc010pkl.1_3'UTR|TOMM40L_uc001fzd.2_3'UTR|TOMM40L_uc009wue.2_3'UTR|TOMM40L_uc009wuf.1_RNA|TOMM40L_uc001fze.2_3'UTR|NR1I3_uc001fzf.2_Missense_Mutation_p.P331S|NR1I3_uc001fzg.2_Missense_Mutation_p.P302S|NR1I3_uc001fzh.2_3'UTR|NR1I3_uc001fzi.2_Missense_Mutation_p.P297S|NR1I3_uc001fzj.2_3'UTR|NR1I3_uc001fzk.2_Missense_Mutation_p.P258S|NR1I3_uc001fzl.2_3'UTR|NR1I3_uc001fzm.2_3'UTR|NR1I3_uc001fzn.2_3'UTR|NR1I3_uc009wug.2_Missense_Mutation_p.P164S|NR1I3_uc001fzp.2_3'UTR|NR1I3_uc001fzo.2_3'UTR|NR1I3_uc001fzq.2_3'UTR|NR1I3_uc001fzr.2_3'UTR|NR1I3_uc001fzs.2_Missense_Mutation_p.P120S|NR1I3_uc001fzt.2_3'UTR|NR1I3_uc001fzu.2_3'UTR|NR1I3_uc001fzv.2_3'UTR|NR1I3_uc001fzw.2_Missense_Mutation_p.P330S|NR1I3_uc001fzy.2_3'UTR|NR1I3_uc001fzz.2_3'UTR|NR1I3_uc001gaa.2_Missense_Mutation_p.P287S|NR1I3_uc001gab.2_3'UTR|NR1I3_uc001gac.2_Missense_Mutation_p.P306S	NM_001077480	NP_001070948			constitutive androstane receptor isoform 2						regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	androgen receptor activity|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity|transcription coactivator activity|zinc ion binding			ovary(1)|skin(1)	2	all_cancers(52;1.86e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)															---	---	---	---
FCRLB	127943	broad.mit.edu	37	1	161697204	161697204	+	Missense_Mutation	SNP	G	A	A	rs145348831		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:161697204G>A	uc001gbh.2	+	8	1267	c.1033G>A	c.(1033-1035)GGC>AGC	p.G345S	FCRLB_uc009wus.2_Missense_Mutation_p.G345S|FCRLB_uc001gbj.2_Silent_p.A296A|FCRLB_uc001gbk.2_3'UTR|FCRLB_uc001gbl.2_Silent_p.A289A|FCRLB_uc001gbm.2_3'UTR|FCRLB_uc001gbi.2_Missense_Mutation_p.G345S|FCRLB_uc001gbn.3_3'UTR	NM_001002901	NP_001002901	Q6BAA4	FCRLB_HUMAN	Fc receptor-like B	345						endoplasmic reticulum					0	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)															---	---	---	---
TADA1	117143	broad.mit.edu	37	1	166827446	166827446	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:166827446C>T	uc001gdw.2	-	7	949	c.765G>A	c.(763-765)CAG>CAA	p.Q255Q	TADA1_uc001gdv.2_Silent_p.Q113Q	NM_053053	NP_444281	Q96BN2	TADA1_HUMAN	transcriptional adaptor 1-like	255					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			ovary(1)	1																		---	---	---	---
GPA33	10223	broad.mit.edu	37	1	167038309	167038309	+	Missense_Mutation	SNP	C	T	T	rs139630164		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:167038309C>T	uc001gea.1	-	3	609	c.265G>A	c.(265-267)GTC>ATC	p.V89I		NM_005814	NP_005805	Q99795	GPA33_HUMAN	transmembrane glycoprotein A33 precursor	89	Ig-like V-type.|Extracellular (Potential).					integral to plasma membrane	receptor activity				0																		---	---	---	---
F5	2153	broad.mit.edu	37	1	169498918	169498918	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:169498918A>G	uc001ggg.1	-	16	5492	c.5347T>C	c.(5347-5349)TAC>CAC	p.Y1783H		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	1783	F5/8 type A 3.|Plastocyanin-like 6.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)													---	---	---	---
SERPINC1	462	broad.mit.edu	37	1	173881070	173881070	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:173881070C>T	uc001gjt.2	-	3	610	c.491G>A	c.(490-492)CGA>CAA	p.R164Q		NM_000488	NP_000479	P01008	ANT3_HUMAN	serpin peptidase inhibitor, clade C, member 1	164					blood coagulation|regulation of proteolysis	extracellular space|plasma membrane	heparin binding|protease binding|serine-type endopeptidase inhibitor activity			ovary(1)	1					Enoxaparin(DB01225)|Fondaparinux sodium(DB00569)|Heparin(DB01109)													---	---	---	---
PAPPA2	60676	broad.mit.edu	37	1	176679110	176679110	+	Intron	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:176679110T>C	uc001gkz.2	+						PAPPA2_uc009www.2_Intron	NM_020318	NP_064714			pappalysin 2 isoform 1						cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16																		---	---	---	---
TOR3A	64222	broad.mit.edu	37	1	179063240	179063240	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:179063240C>T	uc001gmd.2	+	5	983	c.831C>T	c.(829-831)GGC>GGT	p.G277G	TOR3A_uc010pnd.1_Silent_p.G61G	NM_022371	NP_071766	Q9H497	TOR3A_HUMAN	torsin family 3, member A precursor	277					chaperone mediated protein folding requiring cofactor	endoplasmic reticulum	ATP binding			pancreas(1)	1																		---	---	---	---
TOR1AIP1	26092	broad.mit.edu	37	1	179852002	179852002	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:179852002T>C	uc001gnq.2	+	1	583	c.365T>C	c.(364-366)ATG>ACG	p.M122T	TOR1AIP1_uc001gnp.1_Missense_Mutation_p.M122T	NM_015602	NP_056417	Q5JTV8	TOIP1_HUMAN	lamina-associated polypeptide 1B	122	Nuclear (Potential).					integral to membrane|nuclear inner membrane				breast(1)|central_nervous_system(1)	2																		---	---	---	---
CACNA1E	777	broad.mit.edu	37	1	181702035	181702035	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:181702035G>A	uc001gow.2	+	20	2978	c.2813G>A	c.(2812-2814)CGG>CAG	p.R938Q	CACNA1E_uc009wxs.2_Missense_Mutation_p.R826Q|CACNA1E_uc001gox.1_Missense_Mutation_p.R164Q|CACNA1E_uc009wxt.2_Missense_Mutation_p.R164Q	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	938	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6																		---	---	---	---
ZNF648	127665	broad.mit.edu	37	1	182026619	182026619	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:182026619G>A	uc001goz.2	-	2	735	c.527C>T	c.(526-528)GCG>GTG	p.A176V		NM_001009992	NP_001009992	Q5T619	ZN648_HUMAN	zinc finger protein 648	176					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1																		---	---	---	---
RGS8	85397	broad.mit.edu	37	1	182638780	182638780	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:182638780G>A	uc010pnw.1	-	3	263	c.5C>T	c.(4-6)GCG>GTG	p.A2V	RGS8_uc001gpn.1_Missense_Mutation_p.A2V|RGS8_uc001gpm.1_Intron	NM_001102450	NP_001095920	P57771	RGS8_HUMAN	regulator of G-protein signalling 8 isoform 2	2					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)	1																		---	---	---	---
HMCN1	83872	broad.mit.edu	37	1	185986140	185986140	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:185986140T>C	uc001grq.1	+	33	5466	c.5237T>C	c.(5236-5238)GTG>GCG	p.V1746A		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	1746	Ig-like C2-type 15.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23																		---	---	---	---
HMCN1	83872	broad.mit.edu	37	1	186114659	186114659	+	Silent	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:186114659G>T	uc001grq.1	+	92	14620	c.14391G>T	c.(14389-14391)GGG>GGT	p.G4797G	HMCN1_uc001grs.1_Silent_p.G366G	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4797	TSP type-1 5.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23																		---	---	---	---
TPR	7175	broad.mit.edu	37	1	186325512	186325512	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:186325512C>T	uc001grv.2	-	15	2091	c.1794G>A	c.(1792-1794)CAG>CAA	p.Q598Q		NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	598	Potential.				carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)				T	NTRK1	papillary thyroid								---	---	---	---
ZNF281	23528	broad.mit.edu	37	1	200377574	200377574	+	Silent	SNP	G	A	A	rs149361792		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:200377574G>A	uc001gve.2	-	2	1367	c.1260C>T	c.(1258-1260)ACC>ACT	p.T420T	ZNF281_uc001gvf.1_Silent_p.T420T|ZNF281_uc001gvg.1_Silent_p.T384T	NM_012482	NP_036614	Q9Y2X9	ZN281_HUMAN	zinc finger protein 281	420					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|breast(1)	2																		---	---	---	---
NAV1	89796	broad.mit.edu	37	1	201750154	201750154	+	Silent	SNP	A	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:201750154A>C	uc001gwu.2	+	5	1727	c.1380A>C	c.(1378-1380)TCA>TCC	p.S460S	NAV1_uc001gwv.1_5'UTR|NAV1_uc001gww.1_Silent_p.S69S|NAV1_uc001gwx.2_Silent_p.S69S|NAV1_uc001gwy.1_5'Flank	NM_020443	NP_065176	Q8NEY1	NAV1_HUMAN	neuron navigator 1	460					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(3)|ovary(1)	4																		---	---	---	---
GPR37L1	9283	broad.mit.edu	37	1	202092489	202092489	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:202092489T>C	uc001gxj.2	+	1	461	c.398T>C	c.(397-399)ATC>ACC	p.I133T		NM_004767	NP_004758	O60883	ETBR2_HUMAN	G-protein coupled receptor 37 like 1 precursor	133	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
PPFIA4	8497	broad.mit.edu	37	1	203044731	203044731	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:203044731G>A	uc001gyz.2	+	16	2495	c.1902G>A	c.(1900-1902)GCG>GCA	p.A634A	PPFIA4_uc009xaj.2_Silent_p.A1265A|PPFIA4_uc010pqf.1_Silent_p.A847A|PPFIA4_uc001gza.2_Silent_p.A625A|PPFIA4_uc001gzb.1_Silent_p.A320A|PPFIA4_uc001gzc.1_Silent_p.A176A	NM_015053	NP_055868	O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f	634					cell communication	cell surface|cytoplasm	protein binding			ovary(4)|skin(1)	5																		---	---	---	---
CNTN2	6900	broad.mit.edu	37	1	205039153	205039153	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:205039153G>A	uc001hbr.2	+	18	2664	c.2395G>A	c.(2395-2397)GAG>AAG	p.E799K	CNTN2_uc001hbq.1_Missense_Mutation_p.E690K|CNTN2_uc001hbs.2_Missense_Mutation_p.E587K	NM_005076	NP_005067	Q02246	CNTN2_HUMAN	contactin 2 precursor	799	Fibronectin type-III 2.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			ovary(1)	1	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)															---	---	---	---
SLC26A9	115019	broad.mit.edu	37	1	205902217	205902217	+	Intron	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:205902217A>G	uc001hdq.2	-						SLC26A9_uc001hdp.2_Intron	NM_052934	NP_443166			solute carrier family 26, member 9 isoform a							integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			ovary(1)|skin(1)	2	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)															---	---	---	---
CR1	1378	broad.mit.edu	37	1	207785014	207785014	+	Intron	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:207785014T>C	uc001hfy.2	+						CR1_uc001hfx.2_Intron	NM_000573	NP_000564			complement receptor 1 isoform F precursor						complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3																		---	---	---	---
LAMB3	3914	broad.mit.edu	37	1	209800883	209800883	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:209800883A>G	uc001hhg.2	-	11	1720	c.1330T>C	c.(1330-1332)TGT>CGT	p.C444R	LAMB3_uc009xco.2_Missense_Mutation_p.C444R|LAMB3_uc001hhh.2_Missense_Mutation_p.C444R|LAMB3_uc010psl.1_RNA	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	444	Laminin EGF-like 4.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)												OREG0014217	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
RCOR3	55758	broad.mit.edu	37	1	211469082	211469082	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:211469082T>A	uc001hig.2	+	8	999	c.830T>A	c.(829-831)TTC>TAC	p.F277Y	RCOR3_uc010psv.1_RNA|RCOR3_uc001hie.2_Missense_Mutation_p.F335Y|RCOR3_uc010psw.1_Missense_Mutation_p.F335Y|RCOR3_uc001hif.2_Missense_Mutation_p.F335Y	NM_018254	NP_060724	Q9P2K3	RCOR3_HUMAN	REST corepressor 3 isoform d	277					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.00961)|all cancers(67;0.0999)|Epithelial(68;0.171)														---	---	---	---
NEK2	4751	broad.mit.edu	37	1	211842578	211842578	+	Silent	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:211842578G>T	uc001hir.1	-	6	1008	c.862C>A	c.(862-864)CGA>AGA	p.R288R	NEK2_uc001hiq.1_Silent_p.R288R|NEK2_uc001his.3_Silent_p.R288R|NEK2_uc001hit.1_RNA	NM_002497	NP_002488	P51955	NEK2_HUMAN	NIMA-related kinase 2	288	Interaction with PCNT.				cell division|centrosome separation|G2/M transition of mitotic cell cycle|meiosis|protein autophosphorylation|regulation of mitosis	centrosome|condensed chromosome kinetochore|cytosol|nucleolus	ATP binding|metal ion binding|protein binding|protein phosphatase binding|protein serine/threonine kinase activity			breast(2)|stomach(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.00203)|all cancers(67;0.0339)|Epithelial(68;0.0546)														---	---	---	---
INTS7	25896	broad.mit.edu	37	1	212180670	212180670	+	Silent	SNP	C	T	T	rs150638626	byFrequency	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:212180670C>T	uc001hiw.1	-	6	783	c.678G>A	c.(676-678)CCG>CCA	p.P226P	INTS7_uc009xdb.1_Silent_p.P226P|INTS7_uc001hix.1_Silent_p.P102P|INTS7_uc001hiy.1_Silent_p.P226P|INTS7_uc010pta.1_Silent_p.P177P	NM_015434	NP_056249	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	226					snRNA processing	integrator complex	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)														---	---	---	---
TATDN3	128387	broad.mit.edu	37	1	212968473	212968473	+	Intron	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:212968473A>G	uc001hjo.2	+						TATDN3_uc010ptj.1_Intron|TATDN3_uc010ptk.1_Intron|TATDN3_uc001hjp.2_Intron|TATDN3_uc010ptl.1_Intron|TATDN3_uc010ptm.1_Intron	NM_001042552	NP_001036017			TatD DNase domain containing 3 isoform 1							nucleus	endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00699)|all cancers(67;0.0118)|GBM - Glioblastoma multiforme(131;0.0801)|Epithelial(68;0.104)														---	---	---	---
PROX1	5629	broad.mit.edu	37	1	214170355	214170355	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:214170355T>A	uc001hkh.2	+	2	749	c.477T>A	c.(475-477)GAT>GAA	p.D159E	PROX1_uc001hkg.1_Missense_Mutation_p.D159E	NM_002763	NP_002754	Q92786	PROX1_HUMAN	prospero homeobox 1	159					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(3)|lung(1)|central_nervous_system(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)														---	---	---	---
DISP1	84976	broad.mit.edu	37	1	223177115	223177115	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:223177115C>T	uc001hnu.1	+	8	2523	c.2376C>T	c.(2374-2376)GGC>GGT	p.G792G		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	792					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)														---	---	---	---
WDR26	80232	broad.mit.edu	37	1	224592126	224592126	+	Intron	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:224592126G>A	uc001hop.3	-						WDR26_uc001hoq.3_Intron|WDR26_uc010pvh.1_Intron	NM_025160	NP_079436			WD repeat domain 26 isoform a							cytoplasm|nucleus					0				GBM - Glioblastoma multiforme(131;0.0104)														---	---	---	---
TMEM63A	9725	broad.mit.edu	37	1	226054855	226054855	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:226054855G>A	uc001hpm.1	-	8	773	c.523C>T	c.(523-525)CCG>TCG	p.P175S	TMEM63A_uc010pvi.1_Missense_Mutation_p.P175S	NM_014698	NP_055513	O94886	TM63A_HUMAN	transmembrane protein 63A	175						integral to membrane|lysosomal membrane	nucleotide binding			ovary(1)|breast(1)	2	Breast(184;0.197)																	---	---	---	---
LEFTY2	7044	broad.mit.edu	37	1	226127115	226127115	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:226127115G>A	uc001hpt.1	-	3	763	c.683C>T	c.(682-684)GCC>GTC	p.A228V	LEFTY2_uc010pvk.1_Missense_Mutation_p.A194V|LEFTY2_uc009xek.1_Intron	NM_003240	NP_003231	O00292	LFTY2_HUMAN	endometrial bleeding associated factor	228					cell growth|multicellular organismal development|platelet activation|platelet degranulation|transforming growth factor beta receptor signaling pathway	extracellular space|platelet alpha granule lumen	cytokine activity|growth factor activity|transforming growth factor beta receptor binding				0	Breast(184;0.197)																	---	---	---	---
CABC1	56997	broad.mit.edu	37	1	227152949	227152949	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:227152949C>T	uc001hqm.1	+	8	3845	c.426C>T	c.(424-426)AAC>AAT	p.N142N	CABC1_uc010pvp.1_Silent_p.N105N|CABC1_uc001hqn.1_Silent_p.N142N|CABC1_uc009xeq.1_Silent_p.N90N|CABC1_uc010pvq.1_Intron|CABC1_uc010pvr.1_5'Flank	NM_020247	NP_064632	Q8NI60	ADCK3_HUMAN	chaperone, ABC1 activity of bc1 complex like	142					cell death	mitochondrion	ATP binding|protein serine/threonine kinase activity				0		Prostate(94;0.0771)																---	---	---	---
PRSS38	339501	broad.mit.edu	37	1	228033279	228033279	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:228033279C>A	uc001hrh.2	+	4	692	c.692C>A	c.(691-693)GCT>GAT	p.A231D		NM_183062	NP_898885	A1L453	PRS38_HUMAN	marapsin 2 precursor	231	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)|pancreas(1)	2																		---	---	---	---
WNT9A	7483	broad.mit.edu	37	1	228109597	228109597	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:228109597G>A	uc001hri.2	-	4	808	c.720C>T	c.(718-720)GGC>GGT	p.G240G		NM_003395	NP_003386	O14904	WNT9A_HUMAN	wingless-type MMTV integration site family,	240					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|cornea development in camera-type eye|embryonic arm morphogenesis|embryonic skeletal joint morphogenesis|endoderm development|iris morphogenesis|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|neuron differentiation|positive regulation of smoothened signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding|signal transducer activity			central_nervous_system(1)|pancreas(1)	2		Prostate(94;0.0405)																---	---	---	---
OBSCN	84033	broad.mit.edu	37	1	228466970	228466970	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:228466970G>A	uc009xez.1	+	27	7265	c.7221G>A	c.(7219-7221)GTG>GTA	p.V2407V	OBSCN_uc001hsn.2_Silent_p.V2407V|OBSCN_uc001hsp.1_Silent_p.V106V|OBSCN_uc001hsq.1_5'Flank	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	2407					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)																---	---	---	---
OBSCN	84033	broad.mit.edu	37	1	228504492	228504492	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:228504492C>T	uc009xez.1	+	51	13412	c.13368C>T	c.(13366-13368)AGC>AGT	p.S4456S	OBSCN_uc001hsn.2_Silent_p.S4456S	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	4456	Ig-like 46.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)																---	---	---	---
OBSCN	84033	broad.mit.edu	37	1	228528927	228528927	+	Silent	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:228528927C>A	uc009xez.1	+	73	17873	c.17829C>A	c.(17827-17829)GTC>GTA	p.V5943V	OBSCN_uc001hsn.2_Silent_p.V5943V|OBSCN_uc001hsr.1_Silent_p.V572V	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	5943	PH.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)																---	---	---	---
OBSCN	84033	broad.mit.edu	37	1	228550350	228550350	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:228550350C>T	uc009xez.1	+	80	18779	c.18735C>T	c.(18733-18735)GGC>GGT	p.G6245G	OBSCN_uc001hsr.1_Silent_p.G874G	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	6245					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)																---	---	---	---
NUP133	55746	broad.mit.edu	37	1	229635518	229635518	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:229635518C>T	uc001htn.2	-	5	653	c.561G>A	c.(559-561)TGG>TGA	p.W187*		NM_018230	NP_060700	Q8WUM0	NU133_HUMAN	nucleoporin 133kDa	187					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			breast(4)|skin(2)|ovary(1)	7	Breast(184;0.104)|Ovarian(103;0.249)	Prostate(94;0.167)																---	---	---	---
ABCB10	23456	broad.mit.edu	37	1	229683388	229683388	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:229683388A>G	uc001htp.3	-	3	822	c.779T>C	c.(778-780)GTT>GCT	p.V260A		NM_012089	NP_036221	Q9NRK6	ABCBA_HUMAN	ATP-binding cassette, sub-family B, member 10	260	Mitochondrial intermembrane (Potential).|Mitochondrial intermembrane (Potential).|ABC transmembrane type-1.					integral to mitochondrial membrane|mitochondrial inner membrane	ATP binding|oligopeptide-transporting ATPase activity			breast(2)	2	Breast(184;0.143)|Ovarian(103;0.249)	Prostate(94;0.167)																---	---	---	---
C1orf131	128061	broad.mit.edu	37	1	231374652	231374652	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:231374652T>C	uc001hun.1	-	2	438	c.401A>G	c.(400-402)CAC>CGC	p.H134R	C1orf131_uc001hul.2_Missense_Mutation_p.H134R|C1orf131_uc001hum.2_Missense_Mutation_p.H134R|C1orf131_uc010pwd.1_Missense_Mutation_p.H134R|C1orf131_uc001huo.1_Missense_Mutation_p.H134R|GNPAT_uc009xfo.1_5'Flank|GNPAT_uc001hup.3_5'Flank|GNPAT_uc009xfp.2_5'Flank	NM_152379	NP_689592	Q8NDD1	CA131_HUMAN	hypothetical protein LOC128061	134										central_nervous_system(1)|skin(1)	2	Breast(184;0.0871)	all_cancers(173;0.2)|Prostate(94;0.183)																---	---	---	---
SIPA1L2	57568	broad.mit.edu	37	1	232626679	232626679	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:232626679G>A	uc001hvg.2	-	3	1905	c.1747C>T	c.(1747-1749)CGA>TGA	p.R583*		NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	583					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)																---	---	---	---
TARBP1	6894	broad.mit.edu	37	1	234573130	234573130	+	Intron	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:234573130C>A	uc001hwd.2	-							NM_005646	NP_005637			TAR RNA binding protein 1						regulation of transcription from RNA polymerase II promoter|RNA processing	nucleus	RNA binding|RNA methyltransferase activity			ovary(2)|skin(1)	3	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)															---	---	---	---
LYST	1130	broad.mit.edu	37	1	235887386	235887386	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:235887386G>T	uc001hxj.2	-	39	9432	c.9257C>A	c.(9256-9258)GCT>GAT	p.A3086D	LYST_uc001hxi.2_Missense_Mutation_p.A310D	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	3086					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)											Chediak-Higashi_syndrome				---	---	---	---
NID1	4811	broad.mit.edu	37	1	236144978	236144978	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:236144978G>A	uc001hxo.2	-	16	3262	c.3160C>T	c.(3160-3162)CAG>TAG	p.Q1054*	NID1_uc009xgd.2_Nonsense_Mutation_p.Q921*|NID1_uc009xgc.2_Nonsense_Mutation_p.Q135*	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	1054	LDL-receptor class B 2.				cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)													---	---	---	---
LGALS8	3964	broad.mit.edu	37	1	236706848	236706848	+	Intron	SNP	G	A	A	rs78743935	byFrequency;by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:236706848G>A	uc001hxz.1	+						LGALS8_uc001hxw.1_Intron|LGALS8_uc001hxy.1_Intron|LGALS8_uc009xgg.1_RNA|LGALS8_uc001hya.1_Intron|LGALS8_uc001hyb.1_Intron|LGALS8_uc001hyc.1_Intron	NM_201543	NP_963837			galectin-8 isoform b							cytoplasm|extracellular space	sugar binding			ovary(1)	1	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.0253)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)															---	---	---	---
CEP170	9859	broad.mit.edu	37	1	243349251	243349251	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:243349251T>G	uc001hzs.2	-	10	1804	c.1396A>C	c.(1396-1398)AGT>CGT	p.S466R	CEP170_uc001hzt.2_Intron|CEP170_uc001hzu.2_Intron	NM_014812	NP_055627	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa isoform alpha	466						centriole|microtubule|spindle				ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)															---	---	---	---
NLRP3	114548	broad.mit.edu	37	1	247588075	247588075	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:247588075G>A	uc001icr.2	+	5	1468	c.1330G>A	c.(1330-1332)GTC>ATC	p.V444I	NLRP3_uc001ics.2_Missense_Mutation_p.V444I|NLRP3_uc001icu.2_Missense_Mutation_p.V444I|NLRP3_uc001icw.2_Missense_Mutation_p.V444I|NLRP3_uc001icv.2_Missense_Mutation_p.V444I|NLRP3_uc010pyw.1_Missense_Mutation_p.V442I|NLRP3_uc001ict.1_Missense_Mutation_p.V442I	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	444	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)															---	---	---	---
TRIM58	25893	broad.mit.edu	37	1	248039478	248039478	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:248039478C>A	uc001ido.2	+	6	1196	c.1148C>A	c.(1147-1149)GCC>GAC	p.A383D	OR2W3_uc001idp.1_Intron	NM_015431	NP_056246	Q8NG06	TRI58_HUMAN	tripartite motif-containing 58	383	B30.2/SPRY.					intracellular	zinc ion binding			skin(3)|ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)	7	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)															---	---	---	---
TRIM58	25893	broad.mit.edu	37	1	248039617	248039617	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:248039617T>C	uc001ido.2	+	6	1335	c.1287T>C	c.(1285-1287)GAT>GAC	p.D429D	OR2W3_uc001idp.1_Intron	NM_015431	NP_056246	Q8NG06	TRI58_HUMAN	tripartite motif-containing 58	429	B30.2/SPRY.					intracellular	zinc ion binding			skin(3)|ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)	7	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)															---	---	---	---
OR2L8	391190	broad.mit.edu	37	1	248112583	248112583	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:248112583C>T	uc001idt.1	+	1	424	c.424C>T	c.(424-426)CTG>TTG	p.L142L	OR2L13_uc001ids.2_Intron	NM_001001963	NP_001001963	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L,	142	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)															---	---	---	---
OR2T3	343173	broad.mit.edu	37	1	248637306	248637306	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:248637306A>G	uc001iel.1	+	1	655	c.655A>G	c.(655-657)ATC>GTC	p.I219V		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	219	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)															---	---	---	---
SNTG2	54221	broad.mit.edu	37	2	1161257	1161257	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:1161257C>T	uc002qwq.2	+	7	563	c.435C>T	c.(433-435)GGC>GGT	p.G145G	SNTG2_uc010ewi.2_Intron	NM_018968	NP_061841	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	145	PDZ.				central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)														---	---	---	---
PXDN	7837	broad.mit.edu	37	2	1658274	1658274	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:1658274T>C	uc002qxa.2	-	15	1908	c.1844A>G	c.(1843-1845)GAC>GGC	p.D615G	PXDN_uc002qxb.1_Missense_Mutation_p.D615G	NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	615					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)														---	---	---	---
SOX11	6664	broad.mit.edu	37	2	5833158	5833158	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:5833158C>T	uc002qyj.2	+	1	360	c.305C>T	c.(304-306)GCG>GTG	p.A102V		NM_003108	NP_003099	P35716	SOX11_HUMAN	SRY-box 11	102	HMG box.				cardiac ventricle formation|closure of optic fissure|cornea development in camera-type eye|embryonic digestive tract morphogenesis|embryonic skeletal system morphogenesis|eyelid development in camera-type eye|glial cell proliferation|hard palate development|lens morphogenesis in camera-type eye|limb bud formation|lung morphogenesis|negative regulation of cell death|negative regulation of glial cell proliferation|negative regulation of lymphocyte proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|neural crest cell development|neural tube formation|neuroepithelial cell differentiation|noradrenergic neuron differentiation|outflow tract morphogenesis|positive regulation of BMP signaling pathway|positive regulation of hippo signaling cascade|positive regulation of hormone secretion|positive regulation of neurogenesis|positive regulation of neuron differentiation|positive regulation of ossification|positive regulation of osteoblast differentiation|positive regulation of stem cell proliferation|regulation of transforming growth factor beta receptor signaling pathway|signal transduction involved in G1/S transition checkpoint|soft palate development|somite development|spinal cord development|sympathetic nervous system development|ventricular septum morphogenesis	cytoplasm|nucleolus	enhancer sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription coactivator activity|translation factor activity, nucleic acid binding			central_nervous_system(3)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			OV - Ovarian serous cystadenocarcinoma(76;0.132)														---	---	---	---
GRHL1	29841	broad.mit.edu	37	2	10130834	10130834	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:10130834G>A	uc002raa.2	+	10	1451	c.1280G>A	c.(1279-1281)CGG>CAG	p.R427Q	GRHL1_uc002rab.2_RNA|GRHL1_uc002rad.2_Missense_Mutation_p.R238Q|GRHL1_uc010yjb.1_Missense_Mutation_p.R276Q	NM_198182	NP_937825	Q9NZI5	GRHL1_HUMAN	grainyhead-like 1	427					cellular lipid metabolic process|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding			pancreas(1)|skin(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.246)														---	---	---	---
C2orf50	130813	broad.mit.edu	37	2	11273484	11273484	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:11273484G>A	uc010yji.1	+	1	306	c.24G>A	c.(22-24)GGG>GGA	p.G8G	uc002raz.1_5'Flank|uc002rba.1_5'Flank|C2orf50_uc010yjj.1_Silent_p.G8G	NM_182500	NP_872306	Q96LR7	CB050_HUMAN	hypothetical protein LOC130813	8											0	all_hematologic(175;0.0797)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.0997)|OV - Ovarian serous cystadenocarcinoma(76;0.134)														---	---	---	---
LPIN1	23175	broad.mit.edu	37	2	11944622	11944622	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:11944622G>A	uc010yjn.1	+	16	2253	c.1979G>A	c.(1978-1980)CGC>CAC	p.R660H	LPIN1_uc010yjm.1_Missense_Mutation_p.R745H|LPIN1_uc002rbt.2_Missense_Mutation_p.R660H|LPIN1_uc010yjo.1_Missense_Mutation_p.R161H	NM_145693	NP_663731	Q14693	LPIN1_HUMAN	lipin 1	660	C-LIP.				fatty acid catabolic process|transcription, DNA-dependent|triglyceride biosynthetic process|triglyceride mobilization	cytosol|endoplasmic reticulum membrane	phosphatidate phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.173)														---	---	---	---
SMC6	79677	broad.mit.edu	37	2	17884436	17884436	+	Silent	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:17884436A>G	uc002rco.2	-	19	2426	c.2130T>C	c.(2128-2130)TAT>TAC	p.Y710Y	SMC6_uc010exo.2_Silent_p.Y710Y|SMC6_uc002rcn.2_Silent_p.Y710Y|SMC6_uc002rcp.1_Silent_p.Y736Y|SMC6_uc002rcq.2_Silent_p.Y736Y	NM_001142286	NP_001135758	Q96SB8	SMC6_HUMAN	SMC6 protein	710	Potential.				DNA recombination|DNA repair	chromosome|nucleus	ATP binding			breast(4)|upper_aerodigestive_tract(1)|kidney(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)																	---	---	---	---
APOB	338	broad.mit.edu	37	2	21230729	21230729	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:21230729G>T	uc002red.2	-	26	9139	c.9011C>A	c.(9010-9012)GCT>GAT	p.A3004D		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3004					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)													---	---	---	---
C2orf44	80304	broad.mit.edu	37	2	24262011	24262011	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:24262011G>A	uc002rep.2	-	2	485	c.354C>T	c.(352-354)GGC>GGT	p.G118G	C2orf44_uc010eya.2_Silent_p.G118G	NM_025203	NP_079479	Q9H6R7	CB044_HUMAN	hypothetical protein LOC80304 isoform 1	118							protein binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
AGBL5	60509	broad.mit.edu	37	2	27278919	27278919	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27278919C>T	uc002rie.2	+	7	1495	c.1278C>T	c.(1276-1278)GGC>GGT	p.G426G	AGBL5_uc002ric.2_Silent_p.G426G|AGBL5_uc002rid.2_Silent_p.G426G|AGBL5_uc002rif.2_RNA	NM_021831	NP_068603	Q8NDL9	CBPC5_HUMAN	ATP/GTP binding protein-like 5 isoform 1	426					protein branching point deglutamylation|proteolysis	cytosol|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
CAD	790	broad.mit.edu	37	2	27460681	27460681	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27460681C>T	uc002rji.2	+	29	4821	c.4659C>T	c.(4657-4659)GCC>GCT	p.A1553A	CAD_uc010eyw.2_Silent_p.A1490A	NM_004341	NP_004332	P27708	PYR1_HUMAN	carbamoylphosphate synthetase 2/aspartate	1553	DHOase (dihydroorotase).				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			ovary(4)|large_intestine(2)|kidney(2)|lung(1)|pancreas(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)													---	---	---	---
IFT172	26160	broad.mit.edu	37	2	27688651	27688651	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27688651G>A	uc002rku.2	-	17	1842	c.1791C>T	c.(1789-1791)ATC>ATT	p.I597I		NM_015662	NP_056477	Q9UG01	IF172_HUMAN	selective LIM binding factor homolog	597	TPR 1.				cilium assembly	cilium	binding			large_intestine(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
SPDYA	245711	broad.mit.edu	37	2	29063081	29063081	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:29063081G>A	uc002rmj.2	+	7	802	c.596G>A	c.(595-597)CGT>CAT	p.R199H	SPDYA_uc002rmi.2_Missense_Mutation_p.R199H|SPDYA_uc002rmk.2_Missense_Mutation_p.R199H|SPDYA_uc002rml.2_Missense_Mutation_p.R199H	NM_182756	NP_877433	Q5MJ70	SPDYA_HUMAN	speedy homolog A isoform 1	199	Speedy/Ringo box; Required for CDK- binding (By similarity).				G1/S transition of mitotic cell cycle|multicellular organismal development|positive regulation of cell proliferation|response to DNA damage stimulus	nucleus	protein kinase binding			upper_aerodigestive_tract(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
LTBP1	4052	broad.mit.edu	37	2	33487837	33487837	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:33487837C>T	uc002ros.2	+	14	2467	c.2467C>T	c.(2467-2469)CCC>TCC	p.P823S	LTBP1_uc002rot.2_Missense_Mutation_p.P497S|LTBP1_uc002rou.2_Missense_Mutation_p.P497S|LTBP1_uc002rov.2_Missense_Mutation_p.P444S|LTBP1_uc010ymz.1_Missense_Mutation_p.P497S|LTBP1_uc010yna.1_Missense_Mutation_p.P444S	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	823					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)																---	---	---	---
CRIM1	51232	broad.mit.edu	37	2	36749246	36749246	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:36749246C>T	uc002rpd.2	+	13	2257	c.2218C>T	c.(2218-2220)CGG>TGG	p.R740W		NM_016441	NP_057525	Q9NZV1	CRIM1_HUMAN	cysteine-rich motor neuron 1 precursor	740	Extracellular (Potential).				nervous system development|regulation of cell growth	extracellular region|integral to membrane|plasma membrane	insulin-like growth factor binding|insulin-like growth factor receptor activity|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3		all_hematologic(82;0.131)|Acute lymphoblastic leukemia(82;0.154)																---	---	---	---
ATL2	64225	broad.mit.edu	37	2	38545705	38545705	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:38545705G>T	uc002rqq.2	-	4	605	c.575C>A	c.(574-576)GCT>GAT	p.A192D	ATL2_uc010ynm.1_Missense_Mutation_p.A174D|ATL2_uc010ynn.1_Missense_Mutation_p.A174D|ATL2_uc010yno.1_Missense_Mutation_p.A21D|ATL2_uc002rqs.2_Missense_Mutation_p.A192D|ATL2_uc002rqr.2_Missense_Mutation_p.A21D	NM_001135673	NP_001129145	Q8NHH9	ATLA2_HUMAN	atlastin GTPase 2 isoform 2	192	Cytoplasmic.				endoplasmic reticulum organization|Golgi organization|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	GTP binding|GTPase activity|identical protein binding			ovary(1)|kidney(1)|skin(1)	3																		---	---	---	---
THADA	63892	broad.mit.edu	37	2	43787479	43787479	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:43787479C>T	uc002rsw.3	-	16	2709	c.2357G>A	c.(2356-2358)GGT>GAT	p.G786D	THADA_uc010far.2_Missense_Mutation_p.G55D|THADA_uc002rsx.3_Missense_Mutation_p.G786D|THADA_uc002rsy.3_RNA|THADA_uc010fas.1_RNA|THADA_uc002rsz.2_Missense_Mutation_p.G496D|THADA_uc010fat.1_Intron|THADA_uc002rta.2_Missense_Mutation_p.G496D|THADA_uc002rtb.1_Missense_Mutation_p.G786D|THADA_uc002rtc.3_Missense_Mutation_p.G786D	NM_001083953	NP_001077422	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	786							binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)																---	---	---	---
SIX2	10736	broad.mit.edu	37	2	45235919	45235919	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:45235919C>T	uc002ruo.2	-	1	624	c.331G>A	c.(331-333)GTG>ATG	p.V111M	SIX2_uc002rup.2_Missense_Mutation_p.V111M	NM_016932	NP_058628	Q9NPC8	SIX2_HUMAN	SIX homeobox 2	111						nucleus	sequence-specific DNA binding transcription factor activity			pancreas(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)																---	---	---	---
SRBD1	55133	broad.mit.edu	37	2	45832557	45832557	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:45832557C>T	uc002rus.2	-	2	100	c.24G>A	c.(22-24)GCG>GCA	p.A8A		NM_018079	NP_060549	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	8					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			central_nervous_system(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)															---	---	---	---
LHCGR	3973	broad.mit.edu	37	2	48941140	48941140	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:48941140G>A	uc002rwu.3	-	7	660	c.590C>T	c.(589-591)ACG>ATG	p.T197M	GTF2A1L_uc002rwt.2_Intron|LHCGR_uc002rwv.2_RNA	NM_000233	NP_000224	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	197	Extracellular (Potential).				male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			ovary(3)|lung(2)|breast(2)|skin(1)	8		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)									Familial_Male-Limited_Precocious_Puberty				---	---	---	---
FSHR	2492	broad.mit.edu	37	2	49217744	49217744	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:49217744G>T	uc002rww.2	-	5	481	c.407C>A	c.(406-408)CCA>CAA	p.P136Q	FSHR_uc002rwx.2_Missense_Mutation_p.P136Q|FSHR_uc010fbn.2_Missense_Mutation_p.P136Q|FSHR_uc010fbo.1_RNA	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	136	Extracellular (Potential).|LRR 4.				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)									Gonadal_Dysgenesis_46_XX				---	---	---	---
NRXN1	9378	broad.mit.edu	37	2	50573835	50573835	+	Missense_Mutation	SNP	C	T	T	rs138844263		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:50573835C>T	uc010fbp.2	-	1	1060	c.253G>A	c.(253-255)GGA>AGA	p.G85R	NRXN1_uc002rxb.3_Intron|NRXN1_uc010fbq.2_Intron|NRXN1_uc002rxe.3_Intron|NRXN1_uc002rxc.1_Intron	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	85	Extracellular (Potential).				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)															---	---	---	---
GPR75	10936	broad.mit.edu	37	2	54080672	54080672	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:54080672G>A	uc002rxo.3	-	2	1493	c.1222C>T	c.(1222-1224)CGA>TGA	p.R408*	ASB3_uc002rxi.3_Intron	NM_006794	NP_006785	O95800	GPR75_HUMAN	G protein-coupled receptor 75	408	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|skin(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)															---	---	---	---
CCDC104	112942	broad.mit.edu	37	2	55771388	55771388	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:55771388G>A	uc002ryy.2	+	9	1008	c.810G>A	c.(808-810)CGG>CGA	p.R270R	CCDC104_uc002ryx.2_Silent_p.R295R	NM_080667	NP_542398	Q96G28	CC104_HUMAN	coiled-coil domain containing 104	270										ovary(1)	1			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)															---	---	---	---
PNPT1	87178	broad.mit.edu	37	2	55870544	55870544	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:55870544C>T	uc002rzf.2	-	24	1976	c.1923G>A	c.(1921-1923)CAG>CAA	p.Q641Q	PNPT1_uc002rzg.2_RNA	NM_033109	NP_149100	Q8TCS8	PNPT1_HUMAN	polyribonucleotide nucleotidyltransferase 1	641	KH.				mRNA catabolic process|RNA processing	plasma membrane	3'-5'-exoribonuclease activity|polyribonucleotide nucleotidyltransferase activity|RNA binding				0			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)															---	---	---	---
KIAA1841	84542	broad.mit.edu	37	2	61304055	61304055	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:61304055G>A	uc002saw.3	+	6	735	c.432G>A	c.(430-432)GGG>GGA	p.G144G	KIAA1841_uc002sax.3_5'UTR|KIAA1841_uc002say.2_Silent_p.G144G|KIAA1841_uc002sav.3_Silent_p.G144G	NM_001129993	NP_001123465	Q6NSI8	K1841_HUMAN	KIAA1841 protein isoform a	144											0			Epithelial(17;0.193)															---	---	---	---
USP34	9736	broad.mit.edu	37	2	61475795	61475795	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:61475795C>T	uc002sbe.2	-	49	6267	c.6245G>A	c.(6244-6246)CGC>CAC	p.R2082H	USP34_uc002sbf.2_Missense_Mutation_p.R232H	NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	2082					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)															---	---	---	---
ANTXR1	84168	broad.mit.edu	37	2	69472360	69472360	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:69472360C>T	uc002sfg.2	+	18	1794	c.1438C>T	c.(1438-1440)CGC>TGC	p.R480C		NM_032208	NP_115584	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1 isoform 1 precursor	480	Cytoplasmic (Potential).				actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity			ovary(2)|skin(2)	4														Familial_Infantile_Hemangioma				---	---	---	---
ANXA4	307	broad.mit.edu	37	2	70031679	70031679	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:70031679G>A	uc002sfr.3	+	4	339	c.112G>A	c.(112-114)GCC>ACC	p.A38T	ANXA4_uc010yqn.1_RNA|ANXA4_uc002sfs.3_Missense_Mutation_p.A38T|ANXA4_uc010yqo.1_5'UTR	NM_001153	NP_001144	P09525	ANXA4_HUMAN	annexin IV	36	Annexin 1.				anti-apoptosis|signal transduction	cytoplasm	calcium ion binding|calcium-dependent phospholipid binding|phospholipase inhibitor activity				0																		---	---	---	---
FIGLA	344018	broad.mit.edu	37	2	71012593	71012593	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:71012593T>C	uc002she.1	-	3	568	c.563A>G	c.(562-564)CAC>CGC	p.H188R		NM_001004311	NP_001004311	Q6QHK4	FIGLA_HUMAN	factor in the germline alpha	188					multicellular organismal development|oocyte development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcription factor complex	DNA binding|transcription factor binding				0																		---	---	---	---
NAT8	9027	broad.mit.edu	37	2	73868259	73868259	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:73868259C>T	uc002sji.1	-	2	664	c.497G>A	c.(496-498)CGG>CAG	p.R166Q		NM_003960	NP_003951	Q9UHE5	NAT8_HUMAN	N-acetyltransferase 8	166	N-acetyltransferase.				gastrulation with mouth forming second|response to drug	integral to membrane	N-acetyltransferase activity			ovary(1)	1																		---	---	---	---
DCTN1	1639	broad.mit.edu	37	2	74590160	74590160	+	Missense_Mutation	SNP	T	A	A	rs72466493		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:74590160T>A	uc002skx.2	-	29	3801	c.3490A>T	c.(3490-3492)ACA>TCA	p.T1164S	SLC4A5_uc002skl.2_RNA|DCTN1_uc002skt.1_Missense_Mutation_p.T98S|DCTN1_uc002skv.2_Missense_Mutation_p.T1030S|DCTN1_uc002sku.2_Missense_Mutation_p.T1025S|DCTN1_uc002skw.1_Missense_Mutation_p.T1140S|DCTN1_uc010ffd.2_Missense_Mutation_p.T1139S|DCTN1_uc002sky.2_Missense_Mutation_p.T1122S	NM_004082	NP_004073	Q14203	DCTN1_HUMAN	dynactin 1 isoform 1	1164					cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			ovary(3)|skin(2)	5																		---	---	---	---
HTRA2	27429	broad.mit.edu	37	2	74759794	74759794	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:74759794G>A	uc002smi.1	+	7	1766	c.1164G>A	c.(1162-1164)CAG>CAA	p.Q388Q	AUP1_uc002smf.2_5'Flank|AUP1_uc002smg.2_5'Flank|AUP1_uc002smh.2_5'Flank|AUP1_uc010yrx.1_5'Flank|AUP1_uc010yry.1_5'Flank|HTRA2_uc002smj.1_Intron|HTRA2_uc002smk.1_Intron|HTRA2_uc002sml.1_Intron|HTRA2_uc002smm.1_Silent_p.Q129Q|HTRA2_uc002smn.1_Silent_p.Q129Q	NM_013247	NP_037379	O43464	HTRA2_HUMAN	HtrA serine peptidase 2 isoform 1 preproprotein	388	PDZ.				apoptosis|proteolysis|response to stress	CD40 receptor complex|endoplasmic reticulum membrane|internal side of plasma membrane|mitochondrial intermembrane space|mitochondrial membrane|nucleus	serine-type endopeptidase activity|unfolded protein binding			ovary(1)	1																		---	---	---	---
HK2	3099	broad.mit.edu	37	2	75113685	75113685	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:75113685C>T	uc002snd.2	+	15	4030	c.2104C>T	c.(2104-2106)CGG>TGG	p.R702W		NM_000189	NP_000180	P52789	HXK2_HUMAN	hexokinase 2	702	Catalytic.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			ovary(1)|lung(1)	2																		---	---	---	---
HK2	3099	broad.mit.edu	37	2	75113788	75113788	+	Missense_Mutation	SNP	C	T	T	rs146476722	byFrequency	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:75113788C>T	uc002snd.2	+	15	4133	c.2207C>T	c.(2206-2208)CCC>CTC	p.P736L		NM_000189	NP_000180	P52789	HXK2_HUMAN	hexokinase 2	736	Catalytic.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			ovary(1)|lung(1)	2																		---	---	---	---
CTNNA2	1496	broad.mit.edu	37	2	80831288	80831288	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:80831288G>A	uc010ysh.1	+	15	2284	c.2279G>A	c.(2278-2280)CGT>CAT	p.R760H	CTNNA2_uc010yse.1_Missense_Mutation_p.R760H|CTNNA2_uc010ysf.1_Missense_Mutation_p.R760H|CTNNA2_uc010ysg.1_Missense_Mutation_p.R760H|CTNNA2_uc010ysi.1_Missense_Mutation_p.R392H|CTNNA2_uc010ysj.1_Missense_Mutation_p.R89H	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	760					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9																		---	---	---	---
TMEM150A	129303	broad.mit.edu	37	2	85827471	85827471	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:85827471T>C	uc002spw.1	-	4	986	c.265A>G	c.(265-267)ATG>GTG	p.M89V	USP39_uc002sqb.2_5'Flank|TMEM150A_uc002spx.1_Intron|TMEM150A_uc002spz.1_Intron|TMEM150A_uc002sqa.1_Missense_Mutation_p.M5V|TMEM150A_uc002spy.1_Missense_Mutation_p.M89V	NM_001031738	NP_001026908	Q86TG1	T150A_HUMAN	transmembrane protein 150A isoform 1	89	Helical; (Potential).					integral to membrane|plasma membrane					0																		---	---	---	---
USP39	10713	broad.mit.edu	37	2	85852763	85852763	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:85852763T>C	uc002sqe.2	+	5	708	c.672T>C	c.(670-672)ATT>ATC	p.I224I	USP39_uc002sqb.2_5'UTR|USP39_uc010ysu.1_Silent_p.I146I|USP39_uc010ysv.1_Silent_p.I121I|USP39_uc010fgn.1_Silent_p.I224I|USP39_uc002sqf.2_Silent_p.I224I|USP39_uc002sqg.2_Silent_p.I224I|USP39_uc010fgo.2_Silent_p.I224I	NM_006590	NP_006581	Q53GS9	SNUT2_HUMAN	ubiquitin specific protease 39	224					spliceosome assembly|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)	1																		---	---	---	---
IMMT	10989	broad.mit.edu	37	2	86373208	86373208	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:86373208A>C	uc002sqz.3	-	14	2034	c.1646T>G	c.(1645-1647)ATC>AGC	p.I549S	IMMT_uc002sqy.3_Missense_Mutation_p.I290S|IMMT_uc002srb.3_Missense_Mutation_p.I538S|IMMT_uc002sra.3_Missense_Mutation_p.I548S|IMMT_uc010ytd.1_Missense_Mutation_p.I537S|IMMT_uc010yte.1_Missense_Mutation_p.I502S|IMMT_uc002src.1_Missense_Mutation_p.I285S	NM_006839	NP_006830	Q16891	IMMT_HUMAN	inner membrane protein, mitochondrial isoform 1	549	Mitochondrial intermembrane (Potential).					integral to mitochondrial inner membrane	protein binding			skin(1)	1																		---	---	---	---
RMND5A	64795	broad.mit.edu	37	2	86992214	86992214	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:86992214A>G	uc010ytm.1	+	5	963	c.586A>G	c.(586-588)AGA>GGA	p.R196G	RMND5A_uc002srs.3_Intron|RMND5A_uc002srr.2_Missense_Mutation_p.R196G	NM_022780	NP_073617	Q9H871	RMD5A_HUMAN	required for meiotic nuclear division 5 homolog	196	CTLH.									ovary(1)|skin(1)	2																		---	---	---	---
ZNF514	84874	broad.mit.edu	37	2	95815928	95815928	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:95815928T>C	uc002sue.1	-	5	676	c.302A>G	c.(301-303)GAA>GGA	p.E101G	ZNF514_uc002sud.1_Missense_Mutation_p.E174G	NM_032788	NP_116177	Q96K75	ZN514_HUMAN	zinc finger protein 514	101					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
GPAT2	150763	broad.mit.edu	37	2	96697827	96697827	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:96697827C>T	uc002svf.2	-	3	354	c.131G>A	c.(130-132)CGC>CAC	p.R44H	GPAT2_uc002svg.2_5'UTR|GPAT2_uc010yuh.1_Missense_Mutation_p.R44H|GPAT2_uc002svh.2_Missense_Mutation_p.R44H	NM_207328	NP_997211	Q6NUI2	GPAT2_HUMAN	glycerol-3-phosphate acyltransferase 2,	44					glycerol-3-phosphate metabolic process|phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity				0																		---	---	---	---
ITPRIPL1	150771	broad.mit.edu	37	2	96992973	96992973	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:96992973C>T	uc002svx.2	+	3	939	c.604C>T	c.(604-606)CGG>TGG	p.R202W	ITPRIPL1_uc010yuk.1_Missense_Mutation_p.R194W|ITPRIPL1_uc002svy.2_Missense_Mutation_p.R210W|ITPRIPL1_uc010yul.1_Missense_Mutation_p.R194W	NM_001008949	NP_001008949	Q6GPH6	IPIL1_HUMAN	inositol 1,4,5-triphosphate receptor interacting	202	Cytoplasmic (Potential).					integral to membrane				central_nervous_system(2)|ovary(1)	3																		---	---	---	---
NCAPH	23397	broad.mit.edu	37	2	97007608	97007608	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:97007608G>A	uc002svz.1	+	2	332	c.248G>A	c.(247-249)CGC>CAC	p.R83H	NCAPH_uc010fhu.1_Missense_Mutation_p.R59H|NCAPH_uc010fhv.1_Missense_Mutation_p.R72H|NCAPH_uc010yum.1_Missense_Mutation_p.R59H|NCAPH_uc010fhw.1_Missense_Mutation_p.R72H|NCAPH_uc010yun.1_Intron|NCAPH_uc002swa.1_Intron	NM_015341	NP_056156	Q15003	CND2_HUMAN	non-SMC condensin I complex, subunit H	83					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|microtubule cytoskeleton|nucleus				urinary_tract(1)|skin(1)	2		Ovarian(717;0.0221)																---	---	---	---
LYG1	129530	broad.mit.edu	37	2	99901147	99901147	+	Intron	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:99901147G>A	uc002szy.2	-						MRPL30_uc002szl.1_Intron|LYG1_uc010yvo.1_Intron	NM_174898	NP_777558			lysozyme g-like protein 1 precursor						cell wall macromolecule catabolic process|peptidoglycan catabolic process	extracellular region	lysozyme activity				0																		---	---	---	---
REV1	51455	broad.mit.edu	37	2	100022521	100022521	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:100022521A>G	uc002tad.2	-	17	2874	c.2662T>C	c.(2662-2664)TGC>CGC	p.C888R	REV1_uc002tac.2_Missense_Mutation_p.C887R	NM_016316	NP_057400	Q9UBZ9	REV1_HUMAN	REV1-like isoform 1	888					DNA replication|error-prone translesion synthesis|response to UV	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|magnesium ion binding|protein binding			ovary(2)	2													DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					---	---	---	---
REV1	51455	broad.mit.edu	37	2	100029342	100029342	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:100029342T>G	uc002tad.2	-	13	2235	c.2023A>C	c.(2023-2025)ACC>CCC	p.T675P	REV1_uc002tac.2_Missense_Mutation_p.T674P	NM_016316	NP_057400	Q9UBZ9	REV1_HUMAN	REV1-like isoform 1	675					DNA replication|error-prone translesion synthesis|response to UV	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|magnesium ion binding|protein binding			ovary(2)	2													DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					---	---	---	---
REV1	51455	broad.mit.edu	37	2	100038096	100038096	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:100038096C>T	uc002tad.2	-	11	1908	c.1696G>A	c.(1696-1698)GCT>ACT	p.A566T	REV1_uc002tac.2_Missense_Mutation_p.A565T	NM_016316	NP_057400	Q9UBZ9	REV1_HUMAN	REV1-like isoform 1	566	UmuC.				DNA replication|error-prone translesion synthesis|response to UV	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|magnesium ion binding|protein binding			ovary(2)	2													DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					---	---	---	---
SLC9A4	389015	broad.mit.edu	37	2	103095325	103095325	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:103095325G>A	uc002tbz.3	+	2	741	c.284G>A	c.(283-285)GGC>GAC	p.G95D		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	95	Helical; Name=C/M3; (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3																		---	---	---	---
SLC9A2	6549	broad.mit.edu	37	2	103322334	103322334	+	Silent	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:103322334C>A	uc002tca.2	+	11	2149	c.2007C>A	c.(2005-2007)TCC>TCA	p.S669S		NM_003048	NP_003039	Q9UBY0	SL9A2_HUMAN	solute carrier family 9 (sodium/hydrogen	669	Cytoplasmic (Potential).					integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			central_nervous_system(3)|skin(3)|breast(2)	8																		---	---	---	---
NCK2	8440	broad.mit.edu	37	2	106509642	106509642	+	3'UTR	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:106509642G>A	uc002tdg.2	+	5					NCK2_uc002tdh.2_3'UTR|NCK2_uc002tdi.2_3'UTR	NM_003581	NP_003572			NCK adaptor protein 2 isoform A						axon guidance|epidermal growth factor receptor signaling pathway|negative regulation of cell proliferation|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of epidermal growth factor receptor activity|regulation of translation|signal complex assembly|T cell activation	cytosol|endoplasmic reticulum	cytoskeletal adaptor activity|receptor signaling complex scaffold activity			ovary(1)|lung(1)	2																		---	---	---	---
SLC5A7	60482	broad.mit.edu	37	2	108625008	108625008	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:108625008G>T	uc002tdv.2	+	8	1259	c.983G>T	c.(982-984)TGC>TTC	p.C328F	SLC5A7_uc010ywm.1_Missense_Mutation_p.C81F|SLC5A7_uc010fjj.2_Missense_Mutation_p.C328F|SLC5A7_uc010ywn.1_Missense_Mutation_p.C215F	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	328	Helical; (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)													---	---	---	---
ZC3H6	376940	broad.mit.edu	37	2	113081979	113081979	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:113081979C>T	uc002thq.1	+	10	1985	c.1591C>T	c.(1591-1593)CAA>TAA	p.Q531*		NM_198581	NP_940983	P61129	ZC3H6_HUMAN	zinc finger CCCH-type domain containing 6	531	Pro-rich.						nucleic acid binding|zinc ion binding			ovary(3)|central_nervous_system(1)	4																		---	---	---	---
IL1RN	3557	broad.mit.edu	37	2	113877668	113877668	+	Silent	SNP	A	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:113877668A>T	uc002tiz.2	+	2	162	c.36A>T	c.(34-36)GGA>GGT	p.G12G	IL1RN_uc002tix.1_RNA|IL1RN_uc002tiy.2_Intron|IL1RN_uc002tja.2_Intron	NM_173841	NP_776213	P18510	IL1RA_HUMAN	interleukin 1 receptor antagonist isoform 2	Error:Variant_position_missing_in_P18510_after_alignment					immune response|inflammatory response|response to glucocorticoid stimulus	centrosome|extracellular space|nucleus|plasma membrane	cytokine activity|interleukin-1 receptor antagonist activity			skin(2)	2					Anakinra(DB00026)									Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of				---	---	---	---
CYP27C1	339761	broad.mit.edu	37	2	127944844	127944844	+	3'UTR	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:127944844G>T	uc002tod.2	-	8						NM_001001665	NP_001001665			cytochrome P450, family 27, subfamily C,							membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.071)														---	---	---	---
ERCC3	2071	broad.mit.edu	37	2	128015230	128015230	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:128015230G>A	uc002toh.1	-	15	2386	c.2291C>T	c.(2290-2292)TCG>TTG	p.S764L	ERCC3_uc002toe.1_Missense_Mutation_p.S519L|ERCC3_uc002tof.1_Missense_Mutation_p.S700L|ERCC3_uc002tog.1_Missense_Mutation_p.S700L	NM_000122	NP_000113	P19447	ERCC3_HUMAN	excision repair cross-complementing rodent	764					cell cycle checkpoint|DNA topological change|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA duplex unwinding|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein localization|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	3'-5' DNA helicase activity|ATP binding|damaged DNA binding|protein C-terminus binding|protein N-terminus binding|transcription factor binding			ovary(2)|lung(2)|breast(2)|kidney(1)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.073)				Mis|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				---	---	---	---
TUBA3E	112714	broad.mit.edu	37	2	130951418	130951418	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:130951418C>T	uc002tqv.2	-	4	1098	c.997G>A	c.(997-999)GCC>ACC	p.A333T		NM_207312	NP_997195	Q6PEY2	TBA3E_HUMAN	tubulin, alpha 3e	333					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			skin(1)	1	Colorectal(110;0.1)																	---	---	---	---
ARHGEF4	50649	broad.mit.edu	37	2	131798826	131798826	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:131798826G>A	uc002tsa.1	+	9	1648	c.1128G>A	c.(1126-1128)TCG>TCA	p.S376S	ARHGEF4_uc010fmw.1_Intron|ARHGEF4_uc002tsb.1_Silent_p.S376S|ARHGEF4_uc010fmx.1_Silent_p.S316S|ARHGEF4_uc002tsc.1_5'UTR	NM_015320	NP_056135	Q9NR80	ARHG4_HUMAN	Rho guanine nucleotide exchange factor 4 isoform	376	DH.				apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|lamellipodium assembly|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|ruffle membrane	protein domain specific binding|Rac guanyl-nucleotide exchange factor activity			breast(3)|ovary(2)|skin(1)	6		Prostate(154;0.055)		BRCA - Breast invasive adenocarcinoma(221;0.097)														---	---	---	---
ARHGEF4	50649	broad.mit.edu	37	2	131803637	131803637	+	Missense_Mutation	SNP	C	T	T	rs61758709	byFrequency	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:131803637C>T	uc002tsa.1	+	14	2468	c.1948C>T	c.(1948-1950)CGC>TGC	p.R650C	ARHGEF4_uc010fmw.1_Missense_Mutation_p.R798C|ARHGEF4_uc002tsb.1_3'UTR|ARHGEF4_uc010fmx.1_Missense_Mutation_p.R590C|ARHGEF4_uc002tsc.1_Missense_Mutation_p.R193C	NM_015320	NP_056135	Q9NR80	ARHG4_HUMAN	Rho guanine nucleotide exchange factor 4 isoform	650					apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|lamellipodium assembly|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|ruffle membrane	protein domain specific binding|Rac guanyl-nucleotide exchange factor activity			breast(3)|ovary(2)|skin(1)	6		Prostate(154;0.055)		BRCA - Breast invasive adenocarcinoma(221;0.097)														---	---	---	---
LCT	3938	broad.mit.edu	37	2	136546022	136546022	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:136546022C>T	uc002tuu.1	-	17	5667	c.5656G>A	c.(5656-5658)GTT>ATT	p.V1886I		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	1886	Helical; (Potential).				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)														---	---	---	---
LRP1B	53353	broad.mit.edu	37	2	140990876	140990876	+	Missense_Mutation	SNP	G	A	A	rs151022058		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:140990876G>A	uc002tvj.1	-	91	14651	c.13679C>T	c.(13678-13680)CCG>CTG	p.P4560L		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4560	Endocytosis signal (Potential).|Cytoplasmic (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)											TSP Lung(27;0.18)			---	---	---	---
LRP1B	53353	broad.mit.edu	37	2	141267633	141267633	+	Intron	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:141267633A>G	uc002tvj.1	-							NM_018557	NP_061027			low density lipoprotein-related protein 1B						protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)											TSP Lung(27;0.18)			---	---	---	---
MBD5	55777	broad.mit.edu	37	2	149226053	149226053	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:149226053C>T	uc002twm.3	+	9	1529	c.541C>T	c.(541-543)CTA>TTA	p.L181L	MBD5_uc010zbs.1_RNA|MBD5_uc010fns.2_Silent_p.L181L|MBD5_uc002twn.1_5'Flank	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	181						chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)														---	---	---	---
KCNJ3	3760	broad.mit.edu	37	2	155566208	155566208	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:155566208T>C	uc002tyv.1	+	2	991	c.796T>C	c.(796-798)TCC>CCC	p.S266P	KCNJ3_uc010zce.1_Intron	NM_002239	NP_002230	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel J3	266	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			upper_aerodigestive_tract(1)|pancreas(1)	2					Halothane(DB01159)													---	---	---	---
PKP4	8502	broad.mit.edu	37	2	159481795	159481795	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:159481795T>C	uc002tzv.2	+	7	1269	c.1009T>C	c.(1009-1011)TCC>CCC	p.S337P	PKP4_uc002tzt.1_Missense_Mutation_p.S189P|PKP4_uc002tzu.2_Missense_Mutation_p.S337P|PKP4_uc002tzw.2_Missense_Mutation_p.S337P|PKP4_uc002tzx.2_5'UTR|PKP4_uc002tzy.1_5'UTR|PKP4_uc002tzz.1_Missense_Mutation_p.S335P|PKP4_uc002uaa.2_Missense_Mutation_p.S189P	NM_003628	NP_003619	Q99569	PKP4_HUMAN	plakophilin 4 isoform a	337					cell adhesion	desmosome	protein binding			ovary(5)|skin(2)	7															HNSCC(62;0.18)			---	---	---	---
BAZ2B	29994	broad.mit.edu	37	2	160181408	160181408	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:160181408T>C	uc002uao.2	-	36	6619	c.6267A>G	c.(6265-6267)GTA>GTG	p.V2089V	BAZ2B_uc002uap.2_Silent_p.V2053V	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	2089	Bromo.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4																		---	---	---	---
RBMS1	5937	broad.mit.edu	37	2	161223762	161223762	+	Silent	SNP	G	A	A	rs147917487	byFrequency	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:161223762G>A	uc002ubo.2	-	2	660	c.216C>T	c.(214-216)CAC>CAT	p.H72H	RBMS1_uc002ubj.2_Silent_p.H39H|RBMS1_uc002ubk.2_Silent_p.H39H|RBMS1_uc002ubl.2_Silent_p.H70H|RBMS1_uc002ubn.2_Silent_p.H72H|RBMS1_uc002ubi.3_Silent_p.H72H|RBMS1_uc002ubm.2_Silent_p.H39H|RBMS1_uc002ubp.2_Silent_p.H72H|RBMS1_uc010fox.2_Silent_p.H72H	NM_016836	NP_058520	P29558	RBMS1_HUMAN	RNA binding motif, single stranded interacting	72	RRM 1.				DNA replication|RNA processing	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding|single-stranded DNA binding				0																		---	---	---	---
GRB14	2888	broad.mit.edu	37	2	165353779	165353779	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:165353779T>C	uc002ucl.2	-	11	1777	c.1236A>G	c.(1234-1236)TTA>TTG	p.L412L	GRB14_uc010zcv.1_Silent_p.L325L|GRB14_uc002ucm.2_RNA	NM_004490	NP_004481	Q14449	GRB14_HUMAN	growth factor receptor-bound protein 14	412					blood coagulation|leukocyte migration	cytosol|endosome membrane|Golgi membrane|microsome|plasma membrane	SH3/SH2 adaptor activity			ovary(5)|upper_aerodigestive_tract(1)|lung(1)	7																		---	---	---	---
XIRP2	129446	broad.mit.edu	37	2	168106521	168106521	+	Silent	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:168106521A>G	uc002udx.2	+	8	8637	c.8619A>G	c.(8617-8619)CAA>CAG	p.Q2873Q	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.Q2698Q|XIRP2_uc010fpq.2_Silent_p.Q2651Q|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Silent_p.Q219Q	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2698					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14																		---	---	---	---
LRP2	4036	broad.mit.edu	37	2	170097542	170097542	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:170097542C>T	uc002ues.2	-	25	4214	c.4001G>A	c.(4000-4002)GGC>GAC	p.G1334D	LRP2_uc010zdf.1_Missense_Mutation_p.G1197D	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	1334	LDL-receptor class A 15.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)													---	---	---	---
FASTKD1	79675	broad.mit.edu	37	2	170417153	170417153	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:170417153G>A	uc002uev.3	-	5	1103	c.715C>T	c.(715-717)CGA>TGA	p.R239*	FASTKD1_uc002uew.3_RNA|FASTKD1_uc002uex.3_Nonsense_Mutation_p.R225*|FASTKD1_uc002uey.2_Nonsense_Mutation_p.R202*	NM_024622	NP_078898	Q53R41	FAKD1_HUMAN	FAST kinase domains 1	239					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(4)	4																		---	---	---	---
UBR3	130507	broad.mit.edu	37	2	170897447	170897447	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:170897447T>C	uc010zdi.1	+	32	4612	c.4612T>C	c.(4612-4614)TCC>CCC	p.S1538P	UBR3_uc002ufr.3_RNA|UBR3_uc010fqa.2_Missense_Mutation_p.S359P|UBR3_uc002uft.3_Missense_Mutation_p.S395P|UBR3_uc010zdj.1_Missense_Mutation_p.S229P|UBR3_uc002ufu.3_Missense_Mutation_p.S44P	NM_172070	NP_742067	Q6ZT12	UBR3_HUMAN	E3 ubiquitin-protein ligase UBR3	1538					sensory perception of smell|suckling behavior|ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding				0																		---	---	---	---
TTN	7273	broad.mit.edu	37	2	179411522	179411522	+	Missense_Mutation	SNP	G	A	A	rs145099448	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179411522G>A	uc010zfg.1	-	290	87153	c.86929C>T	c.(86929-86931)CGT>TGT	p.R28977C	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R22672C|TTN_uc010zfi.1_Missense_Mutation_p.R22605C|TTN_uc010zfj.1_Missense_Mutation_p.R22480C	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29904							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179441417	179441417	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179441417C>T	uc010zfg.1	-	274	62074	c.61850G>A	c.(61849-61851)CGA>CAA	p.R20617Q	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R14312Q|TTN_uc010zfi.1_Missense_Mutation_p.R14245Q|TTN_uc010zfj.1_Missense_Mutation_p.R14120Q|uc002umv.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	21544							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179590542	179590542	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179590542T>C	uc010zfg.1	-	67	16999	c.16775A>G	c.(16774-16776)CAG>CGG	p.Q5592R	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.Q2253R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6519							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179590718	179590718	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179590718T>C	uc010zfg.1	-	67	16823	c.16599A>G	c.(16597-16599)GAA>GAG	p.E5533E	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.E2194E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6460							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179612257	179612257	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179612257T>G	uc002unb.2	-	46	15094	c.14870A>C	c.(14869-14871)GAA>GCA	p.E4957A	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179612262	179612262	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179612262T>A	uc002unb.2	-	46	15089	c.14865A>T	c.(14863-14865)AAA>AAT	p.K4955N	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179615191	179615191	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179615191T>A	uc002unb.2	-	46	12160	c.11936A>T	c.(11935-11937)AAC>ATC	p.N3979I	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179621109	179621109	+	Silent	SNP	T	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179621109T>A	uc010zfh.1	-	44	10805	c.10581A>T	c.(10579-10581)GCA>GCT	p.A3527A	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron|TTN_uc002unb.2_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179669352	179669352	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179669352C>T	uc002und.2	-	2	243	c.18G>A	c.(16-18)CCG>CCA	p.P6P	TTN_uc010zfg.1_Silent_p.P6P|TTN_uc010zfh.1_Silent_p.P6P|TTN_uc010zfi.1_Silent_p.P6P|TTN_uc010zfj.1_Silent_p.P6P|TTN_uc002unb.2_Silent_p.P6P			Q8WZ42	TITIN_HUMAN	Homo sapiens cDNA FLJ32040 fis, clone NTONG2000858, highly similar to H.sapiens mRNA for titin protein.	6							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
CWC22	57703	broad.mit.edu	37	2	180823790	180823790	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:180823790C>T	uc010frh.1	-	14	1717	c.1417G>A	c.(1417-1419)GCT>ACT	p.A473T	CWC22_uc002uno.2_5'UTR|CWC22_uc002unp.2_Missense_Mutation_p.A473T	NM_020943	NP_065994	Q9HCG8	CWC22_HUMAN	CWC22 spliceosome-associated protein homolog	473	MI.					catalytic step 2 spliceosome	protein binding|RNA binding				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	2	186672757	186672757	+	Intron	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:186672757C>A	uc002upm.2	+						uc010zfu.1_Missense_Mutation_p.P740T					Homo sapiens cDNA FLJ44048 fis, clone TESTI4030669.																														---	---	---	---
ZC3H15	55854	broad.mit.edu	37	2	187373387	187373387	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:187373387A>G	uc002upo.2	+	10	1433	c.1208A>G	c.(1207-1209)GAT>GGT	p.D403G		NM_018471	NP_060941	Q8WU90	ZC3HF_HUMAN	erythropoietin 4 immediate early response	403						cytoplasm|nucleolus|plasma membrane	nucleic acid binding|zinc ion binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Epithelial(96;0.0922)|all cancers(119;0.233)															---	---	---	---
FAM171B	165215	broad.mit.edu	37	2	187605148	187605148	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:187605148C>T	uc002ups.2	+	2	544	c.432C>T	c.(430-432)TAC>TAT	p.Y144Y	FAM171B_uc002upr.1_Silent_p.Y144Y	NM_177454	NP_803237	Q6P995	F171B_HUMAN	KIAA1946	144	Extracellular (Potential).					integral to membrane	DNA binding			ovary(6)|breast(3)|central_nervous_system(1)	10																		---	---	---	---
SDPR	8436	broad.mit.edu	37	2	192711639	192711639	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:192711639C>T	uc002utb.2	-	1	343	c.13G>A	c.(13-15)GCT>ACT	p.A5T		NM_004657	NP_004648	O95810	SDPR_HUMAN	serum deprivation response protein	5						caveola|cytosol	phosphatidylserine binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)													---	---	---	---
GTF3C3	9330	broad.mit.edu	37	2	197629314	197629314	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:197629314C>T	uc002uts.2	-	18	2724	c.2634G>A	c.(2632-2634)ACG>ACA	p.T878T	GTF3C3_uc010zgu.1_Silent_p.T849T	NM_012086	NP_036218	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide	878						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(3)|breast(3)|pancreas(1)	7																		---	---	---	---
PLCL1	5334	broad.mit.edu	37	2	198966086	198966086	+	Splice_Site	SNP	T	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:198966086T>A	uc010fsp.2	+	4	3286	c.2995_splice	c.e4+2	p.G999_splice	PLCL1_uc002uuv.3_Splice_Site_p.G920_splice	NM_001114661	NP_001108133			RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;						intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)													---	---	---	---
ORC2L	4999	broad.mit.edu	37	2	201798663	201798663	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:201798663C>A	uc002uwr.2	-	10	1000	c.743G>T	c.(742-744)AGC>ATC	p.S248I	ORC2L_uc010zhj.1_Missense_Mutation_p.S248I	NM_006190	NP_006181	Q13416	ORC2_HUMAN	origin recognition complex, subunit 2	248					cell cycle checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	DNA replication origin binding|protein binding				0																		---	---	---	---
MPP4	58538	broad.mit.edu	37	2	202552029	202552029	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:202552029C>A	uc002uyk.3	-	5	553	c.345G>T	c.(343-345)CAG>CAT	p.Q115H	MPP4_uc010ftj.2_Missense_Mutation_p.Q115H|MPP4_uc010zhq.1_Missense_Mutation_p.Q115H|MPP4_uc010zhr.1_Missense_Mutation_p.Q115H|MPP4_uc010zhs.1_Missense_Mutation_p.Q115H|MPP4_uc002uyj.3_Missense_Mutation_p.Q115H|MPP4_uc010zht.1_Intron|MPP4_uc002uyl.3_RNA|MPP4_uc010ftk.2_Missense_Mutation_p.Q115H|MPP4_uc002uym.1_Missense_Mutation_p.Q128H|MPP4_uc002uyn.2_Missense_Mutation_p.Q115H	NM_033066	NP_149055	Q96JB8	MPP4_HUMAN	membrane protein, palmitoylated 4	115	L27 2.					cytoplasm	protein binding				0																		---	---	---	---
ALS2	57679	broad.mit.edu	37	2	202622177	202622177	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:202622177T>C	uc002uyo.2	-	5	1775	c.1419A>G	c.(1417-1419)GAA>GAG	p.E473E	ALS2_uc002uyp.3_Silent_p.E473E|ALS2_uc002uyq.2_Silent_p.E473E	NM_020919	NP_065970	Q96Q42	ALS2_HUMAN	alsin isoform 1	473					cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			skin(5)|lung(1)|breast(1)	7																		---	---	---	---
ABI2	10152	broad.mit.edu	37	2	204255835	204255835	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:204255835A>G	uc002vaa.2	+	5	782	c.547A>G	c.(547-549)AGT>GGT	p.S183G	ABI2_uc010zig.1_RNA|ABI2_uc002uzz.2_Missense_Mutation_p.S177G|ABI2_uc010zih.1_Intron|ABI2_uc010zii.1_Missense_Mutation_p.S177G|ABI2_uc010zij.1_Missense_Mutation_p.S121G|ABI2_uc002vab.2_Missense_Mutation_p.S132G|ABI2_uc010zik.1_Missense_Mutation_p.S18G|ABI2_uc010zil.1_Missense_Mutation_p.S18G|ABI2_uc010zim.1_Missense_Mutation_p.S18G|ABI2_uc002vac.2_Missense_Mutation_p.S18G	NM_005759	NP_005750	Q9NYB9	ABI2_HUMAN	abl interactor 2	183	Pro-rich.				actin polymerization or depolymerization|cell migration|peptidyl-tyrosine phosphorylation	cytoskeleton|cytosol|filopodium|lamellipodium	cytoskeletal adaptor activity|DNA binding|kinase binding|proline-rich region binding|SH3 domain binding|ubiquitin protein ligase binding				0																		---	---	---	---
NRP2	8828	broad.mit.edu	37	2	206607957	206607957	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:206607957T>C	uc002vaw.2	+	9	2113	c.1322T>C	c.(1321-1323)CTC>CCC	p.L441P	NRP2_uc002vat.2_Missense_Mutation_p.L441P|NRP2_uc002vau.2_Missense_Mutation_p.L441P|NRP2_uc002vav.2_Missense_Mutation_p.L441P|NRP2_uc002vax.2_Missense_Mutation_p.L441P|NRP2_uc002vay.2_Missense_Mutation_p.L441P|NRP2_uc010fud.2_Missense_Mutation_p.L441P	NM_201266	NP_957718	O60462	NRP2_HUMAN	neuropilin 2 isoform 1 precursor	441	Extracellular (Potential).|F5/8 type C 2.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4																		---	---	---	---
FZD5	7855	broad.mit.edu	37	2	208633251	208633251	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:208633251C>T	uc002vcj.2	-	2	623	c.213G>A	c.(211-213)TGG>TGA	p.W71*		NM_003468	NP_003459	Q13467	FZD5_HUMAN	frizzled 5 precursor	71	FZ.|Extracellular (Potential).				angiogenesis|anterior/posterior axis specification, embryo|axonogenesis|brain development|canonical Wnt receptor signaling pathway|cellular response to molecule of bacterial origin|embryonic camera-type eye development|gonad development|labyrinthine layer blood vessel development|positive regulation of interferon-gamma production|positive regulation of transcription from RNA polymerase II promoter|post-embryonic camera-type eye development|Spemann organizer formation|T cell differentiation in thymus|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell projection|cell surface|Golgi membrane|integral to membrane|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|protein kinase binding|Wnt-protein binding			ovary(2)|lung(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.13)|Lung(261;0.134)														---	---	---	---
FZD5	7855	broad.mit.edu	37	2	208633259	208633259	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:208633259G>A	uc002vcj.2	-	2	615	c.205C>T	c.(205-207)CAG>TAG	p.Q69*		NM_003468	NP_003459	Q13467	FZD5_HUMAN	frizzled 5 precursor	69	FZ.|Extracellular (Potential).				angiogenesis|anterior/posterior axis specification, embryo|axonogenesis|brain development|canonical Wnt receptor signaling pathway|cellular response to molecule of bacterial origin|embryonic camera-type eye development|gonad development|labyrinthine layer blood vessel development|positive regulation of interferon-gamma production|positive regulation of transcription from RNA polymerase II promoter|post-embryonic camera-type eye development|Spemann organizer formation|T cell differentiation in thymus|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell projection|cell surface|Golgi membrane|integral to membrane|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|protein kinase binding|Wnt-protein binding			ovary(2)|lung(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.13)|Lung(261;0.134)														---	---	---	---
PLEKHM3	389072	broad.mit.edu	37	2	208841408	208841408	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:208841408G>A	uc002vcl.2	-	3	2003	c.1513C>T	c.(1513-1515)CGA>TGA	p.R505*	PLEKHM3_uc002vcm.2_Nonsense_Mutation_p.R505*	NM_001080475	NP_001073944	Q6ZWE6	PKHM3_HUMAN	pleckstrin homology domain containing, family M,	505					intracellular signal transduction		metal ion binding			ovary(1)	1																		---	---	---	---
CRYGA	1418	broad.mit.edu	37	2	209025753	209025753	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:209025753G>A	uc002vcq.3	-	3	317	c.300C>T	c.(298-300)GGC>GGT	p.G100G		NM_014617	NP_055432	P11844	CRGA_HUMAN	crystallin, gamma A	100	Beta/gamma crystallin 'Greek key' 3.				visual perception		structural constituent of eye lens				0				Epithelial(149;0.067)|LUSC - Lung squamous cell carcinoma(261;0.0708)|Lung(261;0.135)														---	---	---	---
MAP2	4133	broad.mit.edu	37	2	210559300	210559300	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:210559300G>T	uc002vde.1	+	7	2654	c.2406G>T	c.(2404-2406)ATG>ATT	p.M802I	MAP2_uc002vdc.1_Missense_Mutation_p.M802I|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Missense_Mutation_p.M798I	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	802					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)													---	---	---	---
ATIC	471	broad.mit.edu	37	2	216198174	216198174	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:216198174G>A	uc002vex.3	+	9	1090	c.916G>A	c.(916-918)GCA>ACA	p.A306T	ATIC_uc010zjo.1_Missense_Mutation_p.A247T|ATIC_uc002vey.3_Missense_Mutation_p.A305T	NM_004044	NP_004035	P31939	PUR9_HUMAN	5-aminoimidazole-4-carboxamide ribonucleotide	306					IMP biosynthetic process|purine base metabolic process	cytosol	IMP cyclohydrolase activity|phosphoribosylaminoimidazolecarboxamide formyltransferase activity|protein homodimerization activity		ATIC/ALK(24)	haematopoietic_and_lymphoid_tissue(22)|ovary(2)|lung(2)|soft_tissue(2)|skin(1)	29		Renal(323;0.229)		Epithelial(149;2.02e-06)|all cancers(144;0.000316)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.0097)	Tetrahydrofolic acid(DB00116)			T	ALK	ALCL								---	---	---	---
FN1	2335	broad.mit.edu	37	2	216251612	216251612	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:216251612G>A	uc002vfa.2	-	28	4678	c.4412C>T	c.(4411-4413)GCT>GTT	p.A1471V	FN1_uc002vfb.2_Missense_Mutation_p.A1380V|FN1_uc002vfc.2_Missense_Mutation_p.A1380V|FN1_uc002vfd.2_Missense_Mutation_p.A1471V|FN1_uc002vfe.2_Missense_Mutation_p.A1380V|FN1_uc002vff.2_Missense_Mutation_p.A1380V|FN1_uc002vfg.2_Missense_Mutation_p.A1380V|FN1_uc002vfh.2_Missense_Mutation_p.A1380V|FN1_uc002vfi.2_Missense_Mutation_p.A1471V|FN1_uc002vfj.2_Missense_Mutation_p.A1471V|FN1_uc002vez.2_5'UTR|FN1_uc010zjp.1_Missense_Mutation_p.A98V	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	1470	Fibronectin type-III 10.|Cell-attachment.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
TNS1	7145	broad.mit.edu	37	2	218700768	218700768	+	Silent	SNP	G	A	A	rs61743061	byFrequency;by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:218700768G>A	uc002vgt.2	-	18	3197	c.2799C>T	c.(2797-2799)ATC>ATT	p.I933I	TNS1_uc002vgr.2_Silent_p.I933I|TNS1_uc002vgs.2_Silent_p.I933I|TNS1_uc010zjv.1_Silent_p.I933I	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	933						cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)														---	---	---	---
CCDC108	255101	broad.mit.edu	37	2	219895549	219895549	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:219895549G>A	uc002vjl.1	-	9	1107	c.1023C>T	c.(1021-1023)TGC>TGT	p.C341C	CCDC108_uc010fwa.1_5'Flank|CCDC108_uc010zkp.1_Silent_p.C330C|CCDC108_uc010zkq.1_Silent_p.C276C	NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	341						integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)														---	---	---	---
CHPF	79586	broad.mit.edu	37	2	220404779	220404779	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:220404779G>A	uc002vmc.3	-	4	1881	c.1654C>T	c.(1654-1656)CGC>TGC	p.R552C	CHPF_uc010zlh.1_Missense_Mutation_p.R390C	NM_024536	NP_078812	Q8IZ52	CHSS2_HUMAN	chondroitin polymerizing factor	552	Lumenal (Potential).|Ala-rich.					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity|protein binding				0		Renal(207;0.0183)		Epithelial(149;3.02e-08)|all cancers(144;3.41e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)														---	---	---	---
TMEM198	130612	broad.mit.edu	37	2	220409549	220409549	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:220409549T>C	uc002vme.2	+	3	685	c.100T>C	c.(100-102)TAC>CAC	p.Y34H	CHPF_uc010zlh.1_5'Flank|CHPF_uc002vmc.3_5'Flank|CHPF_uc002vmd.3_5'Flank|TMEM198_uc002vmf.2_Missense_Mutation_p.Y34H	NM_001005209	NP_001005209	Q66K66	TM198_HUMAN	transmembrane protein 198	34						integral to membrane				ovary(1)	1		Renal(207;0.0376)		Epithelial(149;6.49e-08)|all cancers(144;6.45e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)														---	---	---	---
OBSL1	23363	broad.mit.edu	37	2	220432804	220432804	+	Missense_Mutation	SNP	G	A	A	rs79295927		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:220432804G>A	uc010fwk.2	-	2	1312	c.1255C>T	c.(1255-1257)CGC>TGC	p.R419C	OBSL1_uc010fwl.1_5'Flank|OBSL1_uc002vmi.2_Missense_Mutation_p.R419C|OBSL1_uc002vmj.2_Missense_Mutation_p.R6C	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	419	Ig-like 4.				cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)												OREG0003988	type=REGULATORY REGION|Gene=OBSL1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	---	---	---	---
SERPINE2	5270	broad.mit.edu	37	2	224866442	224866442	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:224866442G>A	uc002vnu.2	-	2	419	c.176C>T	c.(175-177)GCG>GTG	p.A59V	SERPINE2_uc002vnt.2_Missense_Mutation_p.A59V|SERPINE2_uc010zlr.1_Missense_Mutation_p.A71V|SERPINE2_uc002vnv.2_Missense_Mutation_p.A59V	NM_006216	NP_006207	P07093	GDN_HUMAN	plasminogen activator inhibitor type 1, member 2	59					negative regulation of blood coagulation|negative regulation of plasminogen activation|negative regulation of platelet aggregation|positive regulation of astrocyte differentiation|regulation of cell migration	cytosol|extracellular matrix|extracellular space|extrinsic to external side of plasma membrane|neuromuscular junction|platelet alpha granule	heparin binding|receptor binding|serine-type endopeptidase inhibitor activity			breast(2)|ovary(1)|central_nervous_system(1)	4		Renal(207;0.025)|all_lung(227;0.0586)|Lung NSC(271;0.0682)|all_hematologic(139;0.0797)		Epithelial(121;5.68e-10)|all cancers(144;1.9e-07)|Lung(261;0.0088)|LUSC - Lung squamous cell carcinoma(224;0.00902)														---	---	---	---
IRS1	3667	broad.mit.edu	37	2	227662389	227662389	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:227662389C>T	uc002voh.3	-	1	1118	c.1066G>A	c.(1066-1068)GCC>ACC	p.A356T		NM_005544	NP_005535	P35568	IRS1_HUMAN	insulin receptor substrate 1	356	Ser-rich.				fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			lung(5)|central_nervous_system(4)|ovary(2)|pancreas(1)	12		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)												OREG0015248	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
SPHKAP	80309	broad.mit.edu	37	2	228882351	228882351	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:228882351G>A	uc002vpq.2	-	7	3266	c.3219C>T	c.(3217-3219)GAC>GAT	p.D1073D	SPHKAP_uc002vpp.2_Silent_p.D1073D|SPHKAP_uc010zlx.1_Silent_p.D1073D	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1073						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)														---	---	---	---
TRIP12	9320	broad.mit.edu	37	2	230642151	230642151	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:230642151C>T	uc002vpw.1	-	36	5293	c.5184G>A	c.(5182-5184)CGG>CGA	p.R1728R	TRIP12_uc002vpx.1_Silent_p.R1776R|TRIP12_uc002vpy.1_Silent_p.R1458R	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1728					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)														---	---	---	---
C2orf57	165100	broad.mit.edu	37	2	232458553	232458553	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:232458553C>T	uc002vrz.2	+	1	942	c.891C>T	c.(889-891)TCC>TCT	p.S297S		NM_152614	NP_689827	Q53QW1	CB057_HUMAN	hypothetical protein LOC165100	297										ovary(1)	1		Renal(207;0.025)|all_hematologic(139;0.0735)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;1.33e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.014)														---	---	---	---
ECEL1	9427	broad.mit.edu	37	2	233348859	233348859	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:233348859G>A	uc002vsv.2	-	7	1464	c.1259C>T	c.(1258-1260)GCA>GTA	p.A420V	ECEL1_uc010fya.1_Missense_Mutation_p.A420V|ECEL1_uc010fyb.1_Missense_Mutation_p.A127V	NM_004826	NP_004817	O95672	ECEL1_HUMAN	endothelin converting enzyme-like 1	420	Lumenal (Potential).				neuropeptide signaling pathway|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity			central_nervous_system(2)	2		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000771)|Lung(119;0.00213)|LUSC - Lung squamous cell carcinoma(224;0.00746)														---	---	---	---
SAG	6295	broad.mit.edu	37	2	234247319	234247319	+	Intron	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:234247319C>T	uc002vuh.2	+						SAG_uc010zmq.1_Intron	NM_000541	NP_000532			S-arrestin						rhodopsin mediated phototransduction|rhodopsin mediated signaling pathway		protein phosphatase inhibitor activity			ovary(1)	1		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.018)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.054)		Epithelial(121;2.86e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00608)|Lung(119;0.00714)|GBM - Glioblastoma multiforme(43;0.207)														---	---	---	---
DNAJB3	414061	broad.mit.edu	37	2	234652528	234652528	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:234652528C>A	uc002vuz.2	-	1	134	c.35G>T	c.(34-36)CGG>CTG	p.R12L	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Intron|UGT1A3_uc002vuy.2_Intron	NM_001001394	NP_001001394	Q8WWF6	DNJB3_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 3	12	J.				protein folding		heat shock protein binding|unfolded protein binding				0																		---	---	---	---
UGT1A5	54579	broad.mit.edu	37	2	234678168	234678168	+	Intron	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:234678168C>T	uc002vuw.2	+						UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Intron|UGT1A3_uc002vuy.2_Intron|UGT1A9_uc002vva.2_Intron|UGT1A1_uc010znc.1_Intron|UGT1A1_uc002vvb.2_Intron	NM_019078	NP_061951			UDP glycosyltransferase 1 family, polypeptide A5						xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;4.51e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000523)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.00645)														---	---	---	---
AGAP1	116987	broad.mit.edu	37	2	237032595	237032595	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:237032595C>T	uc002vvs.2	+	18	2998	c.2403C>T	c.(2401-2403)CAC>CAT	p.H801H	AGAP1_uc002vvt.2_Silent_p.H748H	NM_001037131	NP_001032208	Q9UPQ3	AGAP1_HUMAN	centaurin, gamma 2 isoform 1	801	ANK 2.				protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm	ARF GTPase activator activity|GTP binding|zinc ion binding			ovary(2)|skin(1)	3																		---	---	---	---
CXCR7	57007	broad.mit.edu	37	2	237489456	237489456	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:237489456G>A	uc010fyq.2	+	3	578	c.348G>A	c.(346-348)ACG>ACA	p.T116T	CXCR7_uc002vwd.2_Silent_p.T116T	NM_020311	NP_064707	P25106	CXCR7_HUMAN	chemokine orphan receptor 1	116	Extracellular (Potential).				interspecies interaction between organisms	integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			large_intestine(1)|central_nervous_system(1)|skin(1)	3		Breast(86;0.000182)|Renal(207;0.00339)|all_hematologic(139;0.0048)|Acute lymphoblastic leukemia(138;0.0775)|Ovarian(221;0.089)|all_lung(227;0.147)|all_neural(83;0.223)		Epithelial(121;8.35e-24)|OV - Ovarian serous cystadenocarcinoma(60;7.09e-11)|Kidney(56;1.11e-07)|KIRC - Kidney renal clear cell carcinoma(57;3.03e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000176)|Lung(119;0.00468)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.118)														---	---	---	---
PER2	8864	broad.mit.edu	37	2	239186494	239186494	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:239186494C>T	uc002vyc.2	-	2	321	c.84G>A	c.(82-84)CTG>CTA	p.L28L	PER2_uc010znv.1_Silent_p.L28L|PER2_uc010znw.1_Silent_p.L28L|PER2_uc010fyx.1_Silent_p.L28L	NM_022817	NP_073728	O15055	PER2_HUMAN	period 2	28					circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			upper_aerodigestive_tract(1)|breast(1)	2		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)														---	---	---	---
ASB1	51665	broad.mit.edu	37	2	239344354	239344354	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:239344354G>A	uc002vyg.2	+	3	280	c.194G>A	c.(193-195)CGC>CAC	p.R65H		NM_001040445	NP_001035535	Q9Y576	ASB1_HUMAN	ankyrin repeat and SOCS box-containing protein	65	ANK 1.				intracellular signal transduction|negative regulation of cytokine biosynthetic process						0		all_epithelial(40;2.65e-14)|Breast(86;7.61e-05)|Renal(207;0.00183)|all_lung(227;0.0283)|Ovarian(221;0.0365)|Lung NSC(271;0.0941)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;2.04e-26)|OV - Ovarian serous cystadenocarcinoma(60;4.5e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;2.88e-05)|Lung(119;0.000383)|LUSC - Lung squamous cell carcinoma(224;0.00644)														---	---	---	---
GPC1	2817	broad.mit.edu	37	2	241401788	241401788	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:241401788G>A	uc002vyw.3	+	3	727	c.506G>A	c.(505-507)CGC>CAC	p.R169H		NM_002081	NP_002072	P35052	GPC1_HUMAN	glypican 1 precursor	169					axon guidance	anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			breast(1)	1		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;4.51e-33)|all cancers(36;1.74e-30)|OV - Ovarian serous cystadenocarcinoma(60;4.73e-15)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;9.1e-06)|Colorectal(34;0.000487)|Lung(119;0.0013)|LUSC - Lung squamous cell carcinoma(224;0.0154)|COAD - Colon adenocarcinoma(134;0.0194)|READ - Rectum adenocarcinoma(96;0.0949)														---	---	---	---
ANKMY1	51281	broad.mit.edu	37	2	241468876	241468876	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:241468876G>A	uc002vyz.1	-	4	493	c.264C>T	c.(262-264)CCC>CCT	p.P88P	ANKMY1_uc002vza.1_Intron|ANKMY1_uc010fzd.1_Silent_p.P177P|ANKMY1_uc002vzb.1_Intron|ANKMY1_uc002vzc.1_Intron|ANKMY1_uc002vzd.1_Intron|ANKMY1_uc010fze.1_Intron|ANKMY1_uc002vze.2_Intron	NM_016552	NP_057636	Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	88	MORN 3.						zinc ion binding			central_nervous_system(1)	1		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)														---	---	---	---
CAPN10	11132	broad.mit.edu	37	2	241528895	241528895	+	Intron	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:241528895C>T	uc002vzk.1	+						CAPN10_uc010zoh.1_Intron|CAPN10_uc002vzl.1_Intron|CAPN10_uc002vzm.1_Intron|CAPN10_uc002vzn.1_Intron|CAPN10_uc002vzo.1_Intron|CAPN10_uc010fzg.1_Intron|CAPN10_uc002vzp.1_Intron|CAPN10_uc002vzq.1_Intron	NM_023083	NP_075571			calpain 10 isoform a						actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			ovary(3)|large_intestine(2)|lung(1)	6		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)														---	---	---	---
ING5	84289	broad.mit.edu	37	2	242662669	242662669	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:242662669G>A	uc002wcd.2	+	7	688	c.663G>A	c.(661-663)ACG>ACA	p.T221T		NM_032329	NP_115705	Q8WYH8	ING5_HUMAN	inhibitor of growth family, member 5	221	PHD-type.				DNA replication|histone H3 acetylation|negative regulation of cell proliferation|negative regulation of growth|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;2.16e-33)|all cancers(36;4.99e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.6e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0839)														---	---	---	---
ITPR1	3708	broad.mit.edu	37	3	4730175	4730175	+	Intron	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:4730175A>G	uc003bqa.2	+						ITPR1_uc010hca.1_Intron|ITPR1_uc011asu.1_Intron|ITPR1_uc003bqc.2_Intron	NM_001099952	NP_001093422			inositol 1,4,5-triphosphate receptor, type 1						activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)														---	---	---	---
SETD5	55209	broad.mit.edu	37	3	9512161	9512161	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:9512161C>T	uc003brt.2	+	19	3178	c.2743C>T	c.(2743-2745)CTG>TTG	p.L915L	SETD5_uc003bru.2_Silent_p.L817L|SETD5_uc003brv.2_Silent_p.L804L|SETD5_uc010hck.2_Silent_p.L397L|SETD5_uc003brx.2_Silent_p.L584L	NM_001080517	NP_001073986	Q9C0A6	SETD5_HUMAN	SET domain containing 5	915										ovary(2)	2	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)														---	---	---	---
BRPF1	7862	broad.mit.edu	37	3	9781094	9781094	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:9781094C>T	uc003bse.2	+	3	1410	c.1011C>T	c.(1009-1011)GGC>GGT	p.G337G	BRPF1_uc003bsf.2_Silent_p.G337G|BRPF1_uc003bsg.2_Silent_p.G337G|BRPF1_uc011ati.1_Silent_p.G337G	NM_004634	NP_004625	P55201	BRPF1_HUMAN	bromodomain and PHD finger-containing protein 1	337					histone H3 acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|MOZ/MORF histone acetyltransferase complex|plasma membrane	DNA binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Medulloblastoma(99;0.227)																	---	---	---	---
TTLL3	26140	broad.mit.edu	37	3	9877137	9877137	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:9877137G>A	uc003btg.2	+	13	2499	c.2283G>A	c.(2281-2283)GCG>GCA	p.A761A	ARPC4_uc003btc.1_Intron	NM_001025930	NP_001021100	Q9Y4R7	TTLL3_HUMAN	tubulin tyrosine ligase-like family, member 3	761					axoneme assembly|cilium assembly|protein polyglycylation	cilium axoneme|cytoplasm|microtubule	protein-glycine ligase activity, initiating|tubulin-tyrosine ligase activity			large_intestine(2)	2	Medulloblastoma(99;0.227)																	---	---	---	---
FANCD2	2177	broad.mit.edu	37	3	10114936	10114936	+	Splice_Site	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:10114936G>T	uc003buw.2	+	28	2684	c.2606_splice	c.e28-1	p.E869_splice	FANCD2_uc003bux.1_Splice_Site_p.E869_splice|FANCD2_uc003buy.1_Splice_Site_p.E869_splice|FANCD2_uc010hcw.1_Splice_Site	NM_033084	NP_149075			Fanconi anemia complementation group D2 isoform						DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)				D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				---	---	---	---
TMEM40	55287	broad.mit.edu	37	3	12783970	12783970	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:12783970T>G	uc003bxg.1	-	5	465	c.338A>C	c.(337-339)GAG>GCG	p.E113A	TMEM40_uc003bxh.1_Missense_Mutation_p.E83A|TMEM40_uc003bxi.1_Missense_Mutation_p.E37A|TMEM40_uc011auv.1_Missense_Mutation_p.E129A	NM_018306	NP_060776	Q8WWA1	TMM40_HUMAN	transmembrane protein 40	113						integral to membrane					0																		---	---	---	---
LSM3	27258	broad.mit.edu	37	3	14239580	14239580	+	Silent	SNP	C	T	T	rs112724438	byFrequency	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:14239580C>T	uc003byn.2	+	4	302	c.273C>T	c.(271-273)GGC>GGT	p.G91G	uc003byo.1_5'Flank	NM_014463	NP_055278	P62310	LSM3_HUMAN	Lsm3 protein	91					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	catalytic step 2 spliceosome|cytosol	protein binding|RNA binding			ovary(1)	1																		---	---	---	---
GRIP2	80852	broad.mit.edu	37	3	14554310	14554310	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:14554310G>A	uc011avi.1	-	15	1989	c.1989C>T	c.(1987-1989)AGC>AGT	p.S663S	GRIP2_uc010heh.2_RNA|GRIP2_uc011avh.1_Silent_p.S194S	NM_001080423	NP_001073892	Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2	565	PDZ 5.				synaptic transmission	cytosol|plasma membrane	protein binding			pancreas(1)	1																		---	---	---	---
RFTN1	23180	broad.mit.edu	37	3	16419244	16419244	+	Silent	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:16419244A>G	uc003cay.2	-	5	1089	c.807T>C	c.(805-807)CAT>CAC	p.H269H	RFTN1_uc010hes.2_Silent_p.H233H	NM_015150	NP_055965	Q14699	RFTN1_HUMAN	raft-linking protein	269						plasma membrane				ovary(3)|central_nervous_system(1)	4																		---	---	---	---
TGFBR2	7048	broad.mit.edu	37	3	30713226	30713226	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:30713226T>A	uc003ceo.2	+	4	933	c.551T>A	c.(550-552)ATC>AAC	p.I184N	TGFBR2_uc003cen.2_Missense_Mutation_p.I209N	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II	184	Helical; (Potential).				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26																		---	---	---	---
PDCD6IP	10015	broad.mit.edu	37	3	33907899	33907899	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:33907899A>T	uc003cfx.2	+	18	2644	c.2489A>T	c.(2488-2490)AAT>ATT	p.N830I	PDCD6IP_uc003cfy.2_Missense_Mutation_p.N835I|PDCD6IP_uc011axw.1_Missense_Mutation_p.N611I	NM_013374	NP_037506	Q8WUM4	PDC6I_HUMAN	programmed cell death 6 interacting protein	830	Pro-rich.|Interaction with EIAV p9.|Self-association.				apoptosis|cell cycle|cell division|interspecies interaction between organisms|protein transport	cytosol|melanosome|microtubule organizing center	calcium-dependent protein binding			ovary(1)|skin(1)	2																		---	---	---	---
DLEC1	9940	broad.mit.edu	37	3	38136374	38136374	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:38136374G>A	uc003cho.1	+	13	1945	c.1924G>A	c.(1924-1926)GTG>ATG	p.V642M	DLEC1_uc003chp.1_Missense_Mutation_p.V642M|DLEC1_uc010hgv.1_Missense_Mutation_p.V642M|DLEC1_uc003chr.1_Translation_Start_Site|DLEC1_uc010hgx.1_5'Flank|DLEC1_uc003chq.1_Intron	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	642					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)														---	---	---	---
GORASP1	64689	broad.mit.edu	37	3	39139895	39139895	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:39139895C>T	uc003ciw.1	-	9	1253	c.1155G>A	c.(1153-1155)CAG>CAA	p.Q385Q	GORASP1_uc003civ.1_RNA|GORASP1_uc003cix.1_RNA|GORASP1_uc003ciy.1_RNA|GORASP1_uc011ayw.1_Silent_p.Q290Q|GORASP1_uc003ciz.1_Silent_p.Q230Q	NM_031899	NP_114105	Q9BQQ3	GORS1_HUMAN	Golgi reassembly stacking protein 1	385					mitotic prophase|protein transport	cytosol|Golgi apparatus|membrane				ovary(2)|central_nervous_system(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.0519)|Kidney(284;0.0653)														---	---	---	---
XIRP1	165904	broad.mit.edu	37	3	39227515	39227515	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:39227515C>A	uc003cjk.1	-	2	3643	c.3422G>T	c.(3421-3423)GGC>GTC	p.G1141V	XIRP1_uc003cji.2_Intron|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1141							actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)														---	---	---	---
MYRIP	25924	broad.mit.edu	37	3	40192665	40192665	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:40192665C>T	uc003cka.2	+	4	594	c.459C>T	c.(457-459)TTC>TTT	p.F153F	MYRIP_uc010hhu.2_RNA|MYRIP_uc010hhv.2_Silent_p.F153F|MYRIP_uc010hhw.2_Intron|MYRIP_uc010hhx.1_Silent_p.F153F|MYRIP_uc011ayz.1_5'UTR	NM_015460	NP_056275	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	153	Myosin-binding.				intracellular protein transport		actin binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)														---	---	---	---
ZNF619	285267	broad.mit.edu	37	3	40528780	40528780	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:40528780A>G	uc011azb.1	+	6	1177	c.899A>G	c.(898-900)TAC>TGC	p.Y300C	ZNF619_uc010hhz.2_Missense_Mutation_p.Y251C|ZNF619_uc003ckj.2_Missense_Mutation_p.Y244C|ZNF619_uc011azc.1_Missense_Mutation_p.Y260C|ZNF619_uc011azd.1_Missense_Mutation_p.Y216C|ZNF619_uc011aza.1_Missense_Mutation_p.Y202C	NM_001145082	NP_001138554	E9PCD9	E9PCD9_HUMAN	zinc finger protein 619 isoform 1	300					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)														---	---	---	---
CTNNB1	1499	broad.mit.edu	37	3	41268742	41268742	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:41268742T>C	uc010hia.1	+	8	1136	c.980T>C	c.(979-981)ATA>ACA	p.I327T	CTNNB1_uc003ckp.2_Missense_Mutation_p.I327T|CTNNB1_uc003ckq.2_Missense_Mutation_p.I327T|CTNNB1_uc003ckr.2_Missense_Mutation_p.I327T|CTNNB1_uc011azf.1_Missense_Mutation_p.I320T|CTNNB1_uc011azg.1_Missense_Mutation_p.I255T|uc010hib.1_5'Flank	NM_001904	NP_001895	P35222	CTNB1_HUMAN	beta-catenin	327	ARM 5.				adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding		CTNNB1/PLAG1(60)	liver(806)|soft_tissue(609)|large_intestine(243)|endometrium(222)|kidney(172)|stomach(157)|central_nervous_system(139)|ovary(104)|skin(97)|pancreas(91)|adrenal_gland(85)|pituitary(81)|salivary_gland(62)|haematopoietic_and_lymphoid_tissue(57)|thyroid(55)|biliary_tract(41)|lung(38)|prostate(24)|bone(20)|small_intestine(17)|cervix(9)|parathyroid(9)|urinary_tract(8)|breast(7)|oesophagus(5)|NS(3)|pleura(2)|upper_aerodigestive_tract(2)|eye(1)	3166				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)		15	H|Mis|T	PLAG1	colorectal|cvarian| hepatoblastoma|others|pleomorphic salivary adenoma				Pilomatrixoma_Familial_Clustering_of				---	---	---	---
ULK4	54986	broad.mit.edu	37	3	41607548	41607548	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:41607548T>G	uc003ckv.3	-	32	3395	c.3194A>C	c.(3193-3195)AAA>ACA	p.K1065T		NM_017886	NP_060356	Q96C45	ULK4_HUMAN	unc-51-like kinase 4	1065							ATP binding|protein serine/threonine kinase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.214)														---	---	---	---
TRAK1	22906	broad.mit.edu	37	3	42244033	42244033	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:42244033G>A	uc003cky.2	+	13	1749	c.1533G>A	c.(1531-1533)TCG>TCA	p.S511S	TRAK1_uc011azh.1_Silent_p.S511S|TRAK1_uc011azi.1_Silent_p.S511S|TRAK1_uc003ckz.3_Silent_p.S437S|TRAK1_uc011azj.1_Silent_p.S437S|TRAK1_uc003cla.2_Silent_p.S453S	NM_001042646	NP_001036111	Q9UPV9	TRAK1_HUMAN	OGT(O-Glc-NAc transferase)-interacting protein	511	Potential.				endosome to lysosome transport|protein O-linked glycosylation|protein targeting|regulation of transcription from RNA polymerase II promoter	early endosome|mitochondrion|nucleus				ovary(1)	1																		---	---	---	---
CCDC13	152206	broad.mit.edu	37	3	42772008	42772008	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:42772008C>T	uc003cly.3	-	13	1753	c.1669G>A	c.(1669-1671)GAG>AAG	p.E557K		NM_144719	NP_653320	Q8IYE1	CCD13_HUMAN	coiled-coil domain containing 13	557	Potential.									ovary(1)	1																		---	---	---	---
CYP8B1	1582	broad.mit.edu	37	3	42915802	42915802	+	3'UTR	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:42915802C>T	uc003cmh.2	-	1					CCBP2_uc003cmd.1_Intron|CCBP2_uc003cmg.2_Intron|CYP8B1_uc010hif.2_Intron	NM_004391	NP_004382			cytochrome P450, family 8, subfamily B,						bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity|electron carrier activity|heme binding|oxygen binding|sterol 12-alpha-hydroxylase activity			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.213)|Kidney(284;0.249)														---	---	---	---
SACM1L	22908	broad.mit.edu	37	3	45745000	45745000	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:45745000C>G	uc003cos.2	+	2	307	c.103C>G	c.(103-105)CGT>GGT	p.R35G	SACM1L_uc011bag.1_5'UTR|SACM1L_uc011bah.1_Silent_p.T11T	NM_014016	NP_054735	Q9NTJ5	SAC1_HUMAN	suppressor of actin 1	35						Golgi apparatus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0102)|KIRC - Kidney renal clear cell carcinoma(197;0.0234)|Kidney(197;0.0277)														---	---	---	---
ALS2CL	259173	broad.mit.edu	37	3	46722765	46722765	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:46722765G>A	uc003cqa.1	-	13	1597	c.1407C>T	c.(1405-1407)AGC>AGT	p.S469S	ALS2CL_uc003cpz.1_5'UTR|ALS2CL_uc003cqb.1_Silent_p.S469S|ALS2CL_uc003cqc.1_RNA	NM_147129	NP_667340	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like isoform 1	469	MORN 5.				endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)														---	---	---	---
NBEAL2	23218	broad.mit.edu	37	3	47037248	47037248	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:47037248C>T	uc003cqp.2	+	14	2122	c.1943C>T	c.(1942-1944)GCG>GTG	p.A648V	NBEAL2_uc010hjm.1_Missense_Mutation_p.A209V	NM_015175	NP_055990	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	648							binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)														---	---	---	---
FBXW12	285231	broad.mit.edu	37	3	48422396	48422396	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:48422396A>G	uc003csr.2	+	8	1165	c.979A>G	c.(979-981)ATC>GTC	p.I327V	FBXW12_uc010hjv.2_Missense_Mutation_p.I308V|FBXW12_uc003css.2_Missense_Mutation_p.I257V|FBXW12_uc010hjw.2_Missense_Mutation_p.I226V	NM_207102	NP_996985	Q6X9E4	FBW12_HUMAN	F-box and WD repeat domain containing 12 isoform	327	WD 4.										0				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)														---	---	---	---
COL7A1	1294	broad.mit.edu	37	3	48619157	48619157	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:48619157G>A	uc003ctz.2	-	48	4705	c.4704C>T	c.(4702-4704)ACC>ACT	p.T1568T	MIR711_hsa-mir-711|MI0012488_5'Flank	NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	1568	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)														---	---	---	---
BSN	8927	broad.mit.edu	37	3	49680130	49680130	+	Missense_Mutation	SNP	G	A	A	rs148125466	byFrequency	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49680130G>A	uc003cxe.3	+	3	1177	c.1063G>A	c.(1063-1065)GCG>ACG	p.A355T		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	355					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)														---	---	---	---
HYAL3	8372	broad.mit.edu	37	3	50330907	50330907	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:50330907A>C	uc003czd.1	-	4	1297	c.1024T>G	c.(1024-1026)TTG>GTG	p.L342V	HYAL3_uc003czc.1_Missense_Mutation_p.L312V|HYAL3_uc003cze.1_Missense_Mutation_p.L93V|HYAL3_uc003czf.1_Missense_Mutation_p.L63V|HYAL3_uc003czg.1_Missense_Mutation_p.L312V|IFRD2_uc011bdp.1_5'Flank|IFRD2_uc003czb.2_5'Flank	NM_003549	NP_003540	O43820	HYAL3_HUMAN	hyaluronoglucosaminidase 3 precursor	342					carbohydrate metabolic process	extracellular region|lysosome	hyalurononglucosaminidase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)														---	---	---	---
RAD54L2	23132	broad.mit.edu	37	3	51664851	51664851	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:51664851C>T	uc011bdt.1	+	6	854	c.729C>T	c.(727-729)GAC>GAT	p.D243D	RAD54L2_uc003dbh.2_Translation_Start_Site|RAD54L2_uc011bdu.1_Translation_Start_Site|RAD54L2_uc003dbj.2_Translation_Start_Site	NM_015106	NP_055921	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2	243						nucleus	ATP binding|DNA binding|helicase activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)														---	---	---	---
TEX264	51368	broad.mit.edu	37	3	51733548	51733548	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:51733548C>T	uc010hls.2	+	5	776	c.607C>T	c.(607-609)CGG>TGG	p.R203W	TEX264_uc003dbk.3_Missense_Mutation_p.R203W|TEX264_uc010hlt.2_Missense_Mutation_p.R23W|TEX264_uc003dbl.3_Missense_Mutation_p.R203W|TEX264_uc003dbm.3_Missense_Mutation_p.R242W	NM_001129884	NP_001123356	Q9Y6I9	TX264_HUMAN	testis expressed 264 precursor	203						extracellular region					0				BRCA - Breast invasive adenocarcinoma(193;8.53e-05)|Kidney(197;0.000594)|KIRC - Kidney renal clear cell carcinoma(197;0.000759)														---	---	---	---
TLR9	54106	broad.mit.edu	37	3	52257576	52257576	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52257576G>A	uc003dda.1	-	2	1390	c.756C>T	c.(754-756)GGC>GGT	p.G252G	TLR9_uc003ddb.2_Silent_p.G349G	NM_017442	NP_059138	Q9NR96	TLR9_HUMAN	toll-like receptor 9 isoform A precursor	252	LRR 8.|Extracellular (Potential).				defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			large_intestine(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)													---	---	---	---
ITIH1	3697	broad.mit.edu	37	3	52823879	52823879	+	Intron	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52823879C>T	uc003dfs.2	+						ITIH1_uc010hmn.1_Intron|ITIH1_uc003dft.2_Intron|ITIH1_uc010hmo.1_Intron|ITIH1_uc003dfu.2_Intron	NM_002215	NP_002206			inter-alpha (globulin) inhibitor H1						hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)														---	---	---	---
TMEM110	375346	broad.mit.edu	37	3	52883893	52883893	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52883893G>A	uc003dge.2	-	4	423	c.342C>T	c.(340-342)GGC>GGT	p.G114G	TMEM110_uc003dgc.3_Silent_p.G114G	NM_198563	NP_940965	Q86TL2	TM110_HUMAN	transmembrane protein 110	114	Helical; (Potential).					integral to membrane				large_intestine(1)	1				BRCA - Breast invasive adenocarcinoma(193;7.72e-05)|Kidney(197;0.000777)|KIRC - Kidney renal clear cell carcinoma(197;0.000915)|OV - Ovarian serous cystadenocarcinoma(275;0.0541)														---	---	---	---
IL17RB	55540	broad.mit.edu	37	3	53883679	53883679	+	Intron	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:53883679C>A	uc003dha.2	+							NM_018725	NP_061195			interleukin 17B receptor precursor						defense response|regulation of cell growth	extracellular region|integral to plasma membrane	cytokine receptor activity			ovary(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000158)|KIRC - Kidney renal clear cell carcinoma(284;0.00588)|Kidney(284;0.00673)|OV - Ovarian serous cystadenocarcinoma(275;0.118)														---	---	---	---
CACNA2D3	55799	broad.mit.edu	37	3	54922040	54922040	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:54922040T>A	uc003dhf.2	+	24	2159	c.2111T>A	c.(2110-2112)ATT>AAT	p.I704N	CACNA2D3_uc011beu.1_RNA|CACNA2D3_uc003dhg.1_Missense_Mutation_p.I610N|CACNA2D3_uc003dhh.1_RNA|uc003dhk.1_Intron	NM_018398	NP_060868	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha	704	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			large_intestine(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)														---	---	---	---
C3orf63	23272	broad.mit.edu	37	3	56675690	56675690	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:56675690T>C	uc003did.3	-	15	2407	c.2306A>G	c.(2305-2307)CAT>CGT	p.H769R	C3orf63_uc003dic.3_Missense_Mutation_p.H373R|C3orf63_uc003die.3_Missense_Mutation_p.H769R	NM_015224	NP_056039	Q9UK61	CC063_HUMAN	retinoblastoma-associated protein 140 isoform b	769										ovary(3)|kidney(1)|central_nervous_system(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.0126)|Kidney(284;0.0147)														---	---	---	---
FLNB	2317	broad.mit.edu	37	3	58121816	58121816	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:58121816C>T	uc003djj.2	+	28	4947	c.4782C>T	c.(4780-4782)TAC>TAT	p.Y1594Y	FLNB_uc010hne.2_Silent_p.Y1625Y|FLNB_uc003djk.2_Silent_p.Y1594Y|FLNB_uc010hnf.2_Silent_p.Y1594Y|FLNB_uc003djl.2_Silent_p.Y1425Y|FLNB_uc003djm.2_Silent_p.Y1425Y	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	1594	Filamin 14.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)														---	---	---	---
FAM3D	131177	broad.mit.edu	37	3	58631238	58631238	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:58631238G>A	uc003dkq.2	-	5	558	c.261C>T	c.(259-261)CGC>CGT	p.R87R		NM_138805	NP_620160	Q96BQ1	FAM3D_HUMAN	family with sequence similarity 3, member D	87					negative regulation of insulin secretion	extracellular region	cytokine activity				0				BRCA - Breast invasive adenocarcinoma(55;0.000225)|Kidney(10;0.000667)|KIRC - Kidney renal clear cell carcinoma(10;0.000802)|OV - Ovarian serous cystadenocarcinoma(275;0.169)														---	---	---	---
SLC25A26	115286	broad.mit.edu	37	3	66428192	66428192	+	Silent	SNP	G	A	A	rs147162139		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:66428192G>A	uc011bfq.1	+	11	1514	c.786G>A	c.(784-786)ACG>ACA	p.T262T	SLC25A26_uc011bfs.1_Silent_p.T174T|SLC25A26_uc011bft.1_RNA|SLC25A26_uc011bfr.1_Silent_p.T262T|SLC25A26_uc003dmt.2_3'UTR	NM_173471	NP_775742	Q70HW3	SAMC_HUMAN	solute carrier family 25, member 26 isoform a	262	Solcar 3.					integral to membrane|mitochondrial inner membrane|nucleus	S-adenosylmethionine transmembrane transporter activity			pancreas(1)	1		Lung NSC(201;0.00774)		BRCA - Breast invasive adenocarcinoma(55;0.00046)|KIRC - Kidney renal clear cell carcinoma(15;0.0515)|Kidney(15;0.0648)														---	---	---	---
FLJ10213	55096	broad.mit.edu	37	3	73112038	73112038	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:73112038G>A	uc003dpj.2	+	1	1229	c.806G>A	c.(805-807)CGC>CAC	p.R269H	PPP4R2_uc003dph.1_Intron|PPP4R2_uc003dpi.1_Intron	NM_018029	NP_060499	Q6P2I7	EBLN2_HUMAN	hypothetical protein LOC55096	269							protein binding				0		Prostate(10;0.0187)|Lung SC(41;0.236)		Epithelial(33;3.9e-05)|BRCA - Breast invasive adenocarcinoma(55;7.72e-05)|LUSC - Lung squamous cell carcinoma(21;0.00156)|Lung(16;0.00487)|KIRC - Kidney renal clear cell carcinoma(39;0.012)|Kidney(39;0.0139)														---	---	---	---
ROBO1	6091	broad.mit.edu	37	3	78648053	78648053	+	3'UTR	SNP	T	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:78648053T>A	uc003dqe.2	-	31					ROBO1_uc003dqb.2_3'UTR|ROBO1_uc003dqc.2_3'UTR|ROBO1_uc003dqd.2_3'UTR|ROBO1_uc010hoh.2_3'UTR	NM_002941	NP_002932			roundabout 1 isoform a						activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)														---	---	---	---
PROS1	5627	broad.mit.edu	37	3	93611853	93611853	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:93611853T>A	uc003drb.3	-	10	1420	c.1079A>T	c.(1078-1080)GAA>GTA	p.E360V	PROS1_uc010hoo.2_Missense_Mutation_p.E229V|PROS1_uc003dqz.3_Missense_Mutation_p.E229V	NM_000313	NP_000304	P07225	PROS_HUMAN	protein S, alpha preproprotein	360	Laminin G-like 1.				leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			large_intestine(1)	1					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)													---	---	---	---
STX19	415117	broad.mit.edu	37	3	93733837	93733837	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:93733837T>C	uc003drh.1	-	2	534	c.277A>G	c.(277-279)ACC>GCC	p.T93A	ARL13B_uc003drc.2_Intron|ARL13B_uc010hop.2_Intron|ARL13B_uc003drd.2_Intron|ARL13B_uc003dre.2_Intron|ARL13B_uc003drf.2_Intron|ARL13B_uc003drg.2_Intron	NM_001001850	NP_001001850	Q8N4C7	STX19_HUMAN	syntaxin 19	93					intracellular protein transport|vesicle-mediated transport	membrane	SNAP receptor activity				0																		---	---	---	---
IMPG2	50939	broad.mit.edu	37	3	100972552	100972552	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:100972552C>T	uc003duq.1	-	11	1430	c.1227G>A	c.(1225-1227)CCG>CCA	p.P409P	IMPG2_uc011bhe.1_Silent_p.P272P	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	409	Extracellular (Potential).				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3																		---	---	---	---
SENP7	57337	broad.mit.edu	37	3	101044872	101044872	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:101044872C>T	uc003dut.2	-	24	3179	c.3068G>A	c.(3067-3069)CGT>CAT	p.R1023H	SENP7_uc003duu.2_Missense_Mutation_p.R958H|SENP7_uc003duv.2_Missense_Mutation_p.R990H|SENP7_uc003duw.2_Missense_Mutation_p.R957H|SENP7_uc003dux.2_Missense_Mutation_p.R859H|SENP7_uc003dus.2_Missense_Mutation_p.R211H	NM_020654	NP_065705	Q9BQF6	SENP7_HUMAN	sentrin/SUMO-specific protease 7 isoform 1	1023	Protease.				proteolysis	nucleus	cysteine-type peptidase activity			ovary(3)|lung(2)	5																		---	---	---	---
SENP7	57337	broad.mit.edu	37	3	101083705	101083705	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:101083705T>C	uc003dut.2	-	10	1560	c.1449A>G	c.(1447-1449)CTA>CTG	p.L483L	SENP7_uc003duu.2_Silent_p.L418L|SENP7_uc003duv.2_Silent_p.L450L|SENP7_uc003duw.2_Silent_p.L417L|SENP7_uc003dux.2_Silent_p.L319L	NM_020654	NP_065705	Q9BQF6	SENP7_HUMAN	sentrin/SUMO-specific protease 7 isoform 1	483					proteolysis	nucleus	cysteine-type peptidase activity			ovary(3)|lung(2)	5																		---	---	---	---
BOC	91653	broad.mit.edu	37	3	112991965	112991965	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:112991965C>T	uc003dzx.2	+	8	1632	c.1011C>T	c.(1009-1011)GGC>GGT	p.G337G	BOC_uc003dzy.2_Silent_p.G337G|BOC_uc003dzz.2_Silent_p.G337G|BOC_uc003eab.2_Silent_p.G38G	NM_033254	NP_150279	Q9BWV1	BOC_HUMAN	brother of CDO precursor	337	Ig-like C2-type 4.|Extracellular (Potential).				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|pancreas(1)	6			Epithelial(53;0.227)															---	---	---	---
KIAA2018	205717	broad.mit.edu	37	3	113378505	113378505	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:113378505G>T	uc003eam.2	-	7	2435	c.2024C>A	c.(2023-2025)CCT>CAT	p.P675H	KIAA2018_uc003eal.2_Missense_Mutation_p.P619H	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	675					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3																		---	---	---	---
GOLGB1	2804	broad.mit.edu	37	3	121388136	121388136	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:121388136G>A	uc003eei.3	-	18	9355	c.9229C>T	c.(9229-9231)CGT>TGT	p.R3077C	GOLGB1_uc010hrc.2_Missense_Mutation_p.R3082C|GOLGB1_uc003eej.3_Missense_Mutation_p.R3043C	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	3077	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)														---	---	---	---
ITGB5	3693	broad.mit.edu	37	3	124560272	124560272	+	Silent	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:124560272A>G	uc003eho.2	-	5	1035	c.738T>C	c.(736-738)CCT>CCC	p.P246P		NM_002213	NP_002204	P18084	ITB5_HUMAN	integrin, beta 5 precursor	246	VWFA.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|muscle contraction	integrin complex	receptor activity			skin(2)	2				GBM - Glioblastoma multiforme(114;0.163)														---	---	---	---
PLXNA1	5361	broad.mit.edu	37	3	126741073	126741073	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:126741073C>T	uc003ejg.2	+	21	4119	c.4115C>T	c.(4114-4116)ACG>ATG	p.T1372M		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	1395	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)														---	---	---	---
PLXNA1	5361	broad.mit.edu	37	3	126747142	126747142	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:126747142T>C	uc003ejg.2	+	24	4563	c.4559T>C	c.(4558-4560)GTG>GCG	p.V1520A	PLXNA1_uc003ejh.2_Missense_Mutation_p.V188A	NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	1543	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)														---	---	---	---
MCM2	4171	broad.mit.edu	37	3	127340081	127340081	+	Intron	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:127340081C>T	uc003ejp.2	+						MCM2_uc011bkm.1_Intron|MCM2_uc010hsl.2_Intron|MCM2_uc011bkn.1_Intron	NM_004526	NP_004517			minichromosome maintenance complex component 2						cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|helicase activity|metal ion binding			ovary(3)|skin(1)	4																		---	---	---	---
COPG	22820	broad.mit.edu	37	3	128979597	128979597	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:128979597C>T	uc003els.2	+	12	1175	c.1075C>T	c.(1075-1077)CGC>TGC	p.R359C	COPG_uc010htb.2_Missense_Mutation_p.R265C	NM_016128	NP_057212	Q9Y678	COPG_HUMAN	coatomer protein complex, subunit gamma 1	359	HEAT 4.				COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(3)|breast(1)	4																		---	---	---	---
PIK3R4	30849	broad.mit.edu	37	3	130435316	130435316	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:130435316C>T	uc003enj.2	-	9	2836	c.2255G>A	c.(2254-2256)CGA>CAA	p.R752Q		NM_014602	NP_055417	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	752					fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|breast(2)|skin(2)|stomach(1)|central_nervous_system(1)|kidney(1)	12																		---	---	---	---
DNAJC13	23317	broad.mit.edu	37	3	132184906	132184906	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:132184906C>T	uc003eor.2	+	18	2025	c.1960C>T	c.(1960-1962)CGC>TGC	p.R654C	DNAJC13_uc010htq.1_Missense_Mutation_p.R654C	NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	654							heat shock protein binding			ovary(1)|breast(1)	2																		---	---	---	---
TF	7018	broad.mit.edu	37	3	133467435	133467435	+	Intron	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:133467435C>A	uc003epu.1	+						TF_uc011bls.1_Intron|TF_uc011blt.1_Intron|TF_uc003epw.1_Intron|TF_uc003epv.1_Intron	NM_001063	NP_001054			transferrin precursor						cellular iron ion homeostasis|platelet activation|platelet degranulation|transferrin transport|transmembrane transport	apical plasma membrane|basal plasma membrane|coated pit|early endosome|endocytic vesicle|endosome membrane|extracellular region|late endosome|perinuclear region of cytoplasm|recycling endosome|stored secretory granule	ferric iron binding			ovary(1)|skin(1)	2					Aluminium(DB01370)|Bismuth(DB01402)|Iron Dextran(DB00893)													---	---	---	---
GRK7	131890	broad.mit.edu	37	3	141497732	141497732	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:141497732T>G	uc011bnd.1	+	1	690	c.606T>G	c.(604-606)TTT>TTG	p.F202L		NM_139209	NP_631948	Q8WTQ7	GRK7_HUMAN	G-protein-coupled receptor kinase 7 precursor	202	ATP (By similarity).|Protein kinase.				visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			lung(2)|stomach(1)|ovary(1)|skin(1)	5																		---	---	---	---
AADAC	13	broad.mit.edu	37	3	151545776	151545776	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:151545776C>A	uc003eze.2	+	5	1106	c.1016C>A	c.(1015-1017)ACC>AAC	p.T339N		NM_001086	NP_001077	P22760	AAAD_HUMAN	arylacetamide deacetylase	339	Lumenal (Potential).				positive regulation of triglyceride catabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	carboxylesterase activity|deacetylase activity|serine hydrolase activity|triglyceride lipase activity			skin(2)	2		Myeloproliferative disorder(1037;0.0255)|all_neural(597;0.112)	LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)															---	---	---	---
DHX36	170506	broad.mit.edu	37	3	154022719	154022719	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:154022719A>C	uc003ezy.3	-	8	1092	c.1011T>G	c.(1009-1011)CAT>CAG	p.H337Q	DHX36_uc010hvq.2_Missense_Mutation_p.H337Q|DHX36_uc003ezz.3_Missense_Mutation_p.H337Q	NM_020865	NP_065916	Q9H2U1	DHX36_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 36	337	Helicase ATP-binding.|DEAH box.					cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)															---	---	---	---
PLCH1	23007	broad.mit.edu	37	3	155222380	155222380	+	Silent	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:155222380A>G	uc011bok.1	-	12	1909	c.1632T>C	c.(1630-1632)CAT>CAC	p.H544H	PLCH1_uc011boj.1_Silent_p.H544H|PLCH1_uc011bol.1_Silent_p.H526H	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	544					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)															---	---	---	---
KCNAB1	7881	broad.mit.edu	37	3	155838427	155838427	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:155838427G>A	uc003far.2	+	1	91	c.27G>A	c.(25-27)GCG>GCA	p.A9A	KCNAB1_uc011bon.1_Silent_p.A9A	NM_172160	NP_751892	Q14722	KCAB1_HUMAN	potassium voltage-gated channel, shaker-related	9						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			ovary(3)|skin(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)															---	---	---	---
ACTL6A	86	broad.mit.edu	37	3	179298929	179298929	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:179298929G>A	uc003fjw.2	+	11	1120	c.947G>A	c.(946-948)GGG>GAG	p.G316E	ACTL6A_uc003fjx.2_Missense_Mutation_p.G274E|ACTL6A_uc003fjy.2_Missense_Mutation_p.G274E	NM_004301	NP_004292	O96019	ACL6A_HUMAN	actin-like 6A isoform 1	316					chromatin remodeling|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|nervous system development|regulation of growth|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	Ino80 complex|npBAF complex|NuA4 histone acetyltransferase complex|plasma membrane|SWI/SNF complex	ATP binding|chromatin binding			ovary(1)	1	all_cancers(143;3.94e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)															---	---	---	---
CHRD	8646	broad.mit.edu	37	3	184105786	184105786	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:184105786G>A	uc003fov.2	+	20	2765	c.2519G>A	c.(2518-2520)CGT>CAT	p.R840H	CHRD_uc003fow.2_Missense_Mutation_p.R470H|CHRD_uc003fox.2_Missense_Mutation_p.R840H|CHRD_uc003foy.2_Missense_Mutation_p.R470H|CHRD_uc010hyc.2_Missense_Mutation_p.R430H|CHRD_uc011brr.1_Missense_Mutation_p.R382H	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor	840	VWFC 3.				BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)															---	---	---	---
RTP1	132112	broad.mit.edu	37	3	186917755	186917755	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:186917755C>T	uc003frg.2	+	2	719	c.689C>T	c.(688-690)ACG>ATG	p.T230M		NM_153708	NP_714919	P59025	RTP1_HUMAN	receptor transporting protein 1	230	Cytoplasmic (Potential).				protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding			ovary(2)|breast(1)	3	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.56e-18)	GBM - Glioblastoma multiforme(93;0.0269)														---	---	---	---
LRCH3	84859	broad.mit.edu	37	3	197553878	197553878	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:197553878C>A	uc011bul.1	+	5	775	c.770C>A	c.(769-771)CCT>CAT	p.P257H	LRCH3_uc003fyj.1_Missense_Mutation_p.P257H|LRCH3_uc011bum.1_Missense_Mutation_p.P257H|LRCH3_uc011bun.1_Missense_Mutation_p.P131H|LRCH3_uc003fyk.2_5'Flank	NM_032773	NP_116162	Q96II8	LRCH3_HUMAN	leucine-rich repeats and calponin homology (CH)	257	LRR 8.					extracellular region				ovary(1)	1	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;4.82e-24)|all cancers(36;3.61e-22)|OV - Ovarian serous cystadenocarcinoma(49;7.08e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.119)														---	---	---	---
LMLN	89782	broad.mit.edu	37	3	197703560	197703560	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:197703560G>A	uc011buo.1	+	5	545	c.523G>A	c.(523-525)GTT>ATT	p.V175I	LMLN_uc003fyt.2_Missense_Mutation_p.V123I|LMLN_uc010iar.2_Missense_Mutation_p.V175I|LMLN_uc010ias.2_Missense_Mutation_p.V123I|LMLN_uc003fyu.2_5'UTR	NM_033029	NP_149018	Q96KR4	LMLN_HUMAN	leishmanolysin-like isoform 2	175					cell adhesion|cell division|mitosis|proteolysis	cytoplasm|membrane	metalloendopeptidase activity|zinc ion binding			skin(1)	1	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;9.84e-24)|all cancers(36;3.18e-22)|OV - Ovarian serous cystadenocarcinoma(49;5.35e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.111)														---	---	---	---
LMLN	89782	broad.mit.edu	37	3	197751646	197751646	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:197751646G>A	uc011buo.1	+	14	1665	c.1643G>A	c.(1642-1644)AGC>AAC	p.S548N	LMLN_uc003fyt.2_Missense_Mutation_p.S533N|LMLN_uc010iar.2_Missense_Mutation_p.S585N|LMLN_uc010ias.2_Missense_Mutation_p.S496N|LMLN_uc003fyu.2_Missense_Mutation_p.S345N	NM_033029	NP_149018	Q96KR4	LMLN_HUMAN	leishmanolysin-like isoform 2	548					cell adhesion|cell division|mitosis|proteolysis	cytoplasm|membrane	metalloendopeptidase activity|zinc ion binding			skin(1)	1	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;9.84e-24)|all cancers(36;3.18e-22)|OV - Ovarian serous cystadenocarcinoma(49;5.35e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.111)														---	---	---	---
PDE6B	5158	broad.mit.edu	37	4	657663	657663	+	Intron	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:657663C>T	uc003gap.2	+						PDE6B_uc003gao.3_Intron|PDE6B_uc011buy.1_Intron|PDE6B_uc011buz.1_Intron	NM_000283	NP_000274			phosphodiesterase 6B isoform 1						cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding				0																		---	---	---	---
TACC3	10460	broad.mit.edu	37	4	1729454	1729454	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:1729454G>A	uc003gdo.2	+	4	433	c.325G>A	c.(325-327)GTG>ATG	p.V109M	TACC3_uc010ibz.2_Missense_Mutation_p.V109M|TACC3_uc003gdp.2_Intron	NM_006342	NP_006333	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing	109						centrosome				ovary(1)|central_nervous_system(1)	2		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)															---	---	---	---
WHSC1	7468	broad.mit.edu	37	4	1941423	1941423	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:1941423G>A	uc003gdz.3	+	9	1975	c.1799G>A	c.(1798-1800)CGA>CAA	p.R600Q	WHSC1_uc003geb.3_Missense_Mutation_p.R600Q|WHSC1_uc003gec.3_Missense_Mutation_p.R600Q|WHSC1_uc003ged.3_Missense_Mutation_p.R600Q|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gei.3_5'UTR|WHSC1_uc003gdy.1_Missense_Mutation_p.R600Q|WHSC1_uc010icd.1_Missense_Mutation_p.R600Q|WHSC1_uc003gea.1_Missense_Mutation_p.R600Q|WHSC1_uc010ice.1_Missense_Mutation_p.R600Q|WHSC1_uc003geh.1_Missense_Mutation_p.R600Q	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	600					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)				T	IGH@	MM								---	---	---	---
HTT	3064	broad.mit.edu	37	4	3182362	3182362	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:3182362T>C	uc011bvq.1	+	37	4884	c.4739T>C	c.(4738-4740)CTC>CCC	p.L1580P		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	1578					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)														---	---	---	---
RGS12	6002	broad.mit.edu	37	4	3429895	3429895	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:3429895C>T	uc003ggw.2	+	15	4314	c.3410C>T	c.(3409-3411)ACG>ATG	p.T1137M	RGS12_uc003ggv.2_Missense_Mutation_p.T1137M|RGS12_uc003ggy.1_Missense_Mutation_p.T535M|RGS12_uc003ggz.2_Missense_Mutation_p.T489M|RGS12_uc010icu.1_Missense_Mutation_p.T336M|RGS12_uc011bvs.1_Missense_Mutation_p.T479M|RGS12_uc003gha.2_Missense_Mutation_p.T479M|RGS12_uc010icv.2_Missense_Mutation_p.T336M|RGS12_uc003ghb.2_Missense_Mutation_p.T336M	NM_198229	NP_937872	O14924	RGS12_HUMAN	regulator of G-protein signalling 12 isoform 1	1137						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)														---	---	---	---
DOK7	285489	broad.mit.edu	37	4	3487306	3487306	+	Silent	SNP	G	A	A	rs146277586		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:3487306G>A	uc003ghd.2	+	5	643	c.573G>A	c.(571-573)CAG>CAA	p.Q191Q	DOK7_uc003ghe.2_Silent_p.Q53Q|DOK7_uc003ghf.2_5'UTR	NM_173660	NP_775931	Q18PE1	DOK7_HUMAN	downstream of tyrosine kinase 7 isoform 1	191	IRS-type PTB.				positive regulation of protein tyrosine kinase activity	cell junction|synapse	insulin receptor binding|protein kinase binding			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)														---	---	---	---
CRMP1	1400	broad.mit.edu	37	4	5838577	5838577	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:5838577G>A	uc003gip.2	-	11	1126	c.1025C>T	c.(1024-1026)GCG>GTG	p.A342V	CRMP1_uc003gin.1_Missense_Mutation_p.A254V|CRMP1_uc003giq.2_Missense_Mutation_p.A342V|CRMP1_uc003gir.2_Missense_Mutation_p.A337V|CRMP1_uc003gis.2_Missense_Mutation_p.A456V	NM_001313	NP_001304	Q14194	DPYL1_HUMAN	collapsin response mediator protein 1 isoform 2	342					axon guidance|pyrimidine base catabolic process	cytosol|microtubule organizing center|spindle	dihydropyrimidinase activity|protein binding			ovary(2)	2				Colorectal(103;0.0721)														---	---	---	---
HTRA3	94031	broad.mit.edu	37	4	8293275	8293275	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:8293275C>T	uc003gla.2	+	4	1091	c.887C>T	c.(886-888)ACG>ATG	p.T296M	HTRA3_uc003gkz.2_Missense_Mutation_p.T296M	NM_053044	NP_444272	P83110	HTRA3_HUMAN	HtrA serine peptidase 3 precursor	296	Serine protease.				proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity			ovary(1)	1																		---	---	---	---
ACOX3	8310	broad.mit.edu	37	4	8394073	8394073	+	Silent	SNP	G	A	A	rs148695498		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:8394073G>A	uc010idk.2	-	11	1432	c.1287C>T	c.(1285-1287)CAC>CAT	p.H429H	ACOX3_uc003glc.3_Silent_p.H429H|ACOX3_uc003gld.3_Silent_p.H429H|ACOX3_uc003gle.1_Silent_p.H334H	NM_003501	NP_003492	O15254	ACOX3_HUMAN	acyl-Coenzyme A oxidase 3 isoform a	429					bile acid metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|pristanoyl-CoA oxidase activity			central_nervous_system(1)	1																		---	---	---	---
GPR125	166647	broad.mit.edu	37	4	22415214	22415214	+	Intron	SNP	A	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:22415214A>C	uc003gqm.1	-						GPR125_uc010ieo.1_Intron	NM_145290	NP_660333			G protein-coupled receptor 125 precursor						neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			skin(1)	1		Breast(46;0.198)																---	---	---	---
DHX15	1665	broad.mit.edu	37	4	24542527	24542527	+	Silent	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:24542527A>G	uc003gqx.2	-	9	1698	c.1530T>C	c.(1528-1530)GTT>GTC	p.V510V	DHX15_uc003gqw.2_5'Flank	NM_001358	NP_001349	O43143	DHX15_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 15	510	Helicase C-terminal.				mRNA processing	U12-type spliceosomal complex	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			ovary(1)	1		Breast(46;0.0503)																---	---	---	---
PCDH7	5099	broad.mit.edu	37	4	30724436	30724436	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:30724436C>T	uc003gsk.1	+	1	2400	c.1392C>T	c.(1390-1392)GGC>GGT	p.G464G	PCDH7_uc011bxw.1_Silent_p.G417G|PCDH7_uc011bxx.1_Silent_p.G464G	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	464	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4																		---	---	---	---
RELL1	768211	broad.mit.edu	37	4	37636679	37636679	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:37636679C>T	uc003gsz.2	-	5	600	c.510G>A	c.(508-510)ACG>ACA	p.T170T	RELL1_uc010ifc.2_Silent_p.T170T	NM_001085399	NP_001078868	Q8IUW5	RELL1_HUMAN	receptor expressed in lymphoid tissues like 1	170	Cytoplasmic (Potential).					cytoplasm|integral to membrane|microtubule cytoskeleton|plasma membrane					0																		---	---	---	---
RFC1	5981	broad.mit.edu	37	4	39328186	39328186	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:39328186C>T	uc003gty.1	-	6	773	c.639G>A	c.(637-639)GCG>GCA	p.A213A	RFC1_uc003gtx.1_Silent_p.A213A|RFC1_uc003gtz.1_Silent_p.A97A	NM_002913	NP_002904	P35251	RFC1_HUMAN	replication factor C large subunit	213					DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|telomere maintenance via telomerase|transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4																		---	---	---	---
ATP8A1	10396	broad.mit.edu	37	4	42466947	42466947	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:42466947A>C	uc003gwr.2	-	26	2703	c.2471T>G	c.(2470-2472)CTG>CGG	p.L824R	ATP8A1_uc003gwq.2_Missense_Mutation_p.L50R|ATP8A1_uc003gws.2_Missense_Mutation_p.L809R	NM_006095	NP_006086	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT),	824	Cytoplasmic (Potential).				ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			skin(2)|central_nervous_system(1)	3					Phosphatidylserine(DB00144)													---	---	---	---
SPATA18	132671	broad.mit.edu	37	4	52951146	52951146	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:52951146G>A	uc003gzl.2	+	11	1822	c.1544G>A	c.(1543-1545)AGC>AAC	p.S515N	SPATA18_uc010igl.1_RNA|SPATA18_uc011bzq.1_Missense_Mutation_p.S483N	NM_145263	NP_660306	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18 homolog	515					mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			ovary(2)|skin(2)	4			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)															---	---	---	---
PDGFRA	5156	broad.mit.edu	37	4	55140694	55140694	+	Intron	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:55140694G>A	uc003han.3	+						PDGFRA_uc003haa.2_Intron|PDGFRA_uc010igq.1_Intron|PDGFRA_uc003ham.2_Intron|PDGFRA_uc003hao.1_5'Flank	NM_006206	NP_006197			platelet-derived growth factor receptor alpha						cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			---	---	---	---
PDGFRA	5156	broad.mit.edu	37	4	55143602	55143602	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:55143602G>A	uc003han.3	+	13	2165	c.1834G>A	c.(1834-1836)GCC>ACC	p.A612T	PDGFRA_uc003haa.2_Missense_Mutation_p.A372T|PDGFRA_uc010igq.1_Missense_Mutation_p.A506T|PDGFRA_uc003ham.2_RNA|PDGFRA_uc003hao.1_5'UTR	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	612	Protein kinase.|Cytoplasmic (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			---	---	---	---
KIAA1211	57482	broad.mit.edu	37	4	57181050	57181050	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:57181050G>A	uc003hbk.2	+	8	1773	c.1382G>A	c.(1381-1383)CGA>CAA	p.R461Q	KIAA1211_uc010iha.2_Missense_Mutation_p.R454Q|KIAA1211_uc011bzz.1_Missense_Mutation_p.R371Q|KIAA1211_uc003hbm.1_Missense_Mutation_p.R347Q	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	461	Glu-rich.									ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)																	---	---	---	---
C4orf14	84273	broad.mit.edu	37	4	57839340	57839340	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:57839340T>C	uc003hck.2	-	3	1564	c.1489A>G	c.(1489-1491)ACC>GCC	p.T497A		NM_032313	NP_115689	Q8NC60	CD014_HUMAN	hypothetical protein LOC84273	497							GTP binding			ovary(1)|breast(1)	2	Glioma(25;0.08)|all_neural(26;0.181)																	---	---	---	---
UGT2B10	7365	broad.mit.edu	37	4	69693173	69693173	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:69693173T>C	uc003hee.2	+	5	1239	c.1214T>C	c.(1213-1215)ATG>ACG	p.M405T	UGT2B10_uc011cam.1_Missense_Mutation_p.M321T	NM_001075	NP_001066	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2B10 isoform 1	405					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5																		---	---	---	---
UGT2B28	54490	broad.mit.edu	37	4	70156391	70156391	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:70156391T>C	uc003hej.2	+	5	1174	c.1172T>C	c.(1171-1173)GTA>GCA	p.V391A	UGT2B28_uc010ihr.2_Intron	NM_053039	NP_444267	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family,	391					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1					Flunitrazepam(DB01544)													---	---	---	---
PPEF2	5470	broad.mit.edu	37	4	76781991	76781991	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:76781991G>A	uc003hix.2	-	17	2448	c.2091C>T	c.(2089-2091)ATC>ATT	p.I697I	PPEF2_uc003hiy.2_RNA	NM_006239	NP_006230	O14830	PPE2_HUMAN	serine/threonine protein phosphatase with	697	EF-hand 3.				detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			ovary(2)|lung(1)|central_nervous_system(1)	4			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)															---	---	---	---
PPEF2	5470	broad.mit.edu	37	4	76797712	76797712	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:76797712C>T	uc003hix.2	-	11	1405	c.1048G>A	c.(1048-1050)GAA>AAA	p.E350K	PPEF2_uc003hiy.2_RNA|PPEF2_uc003hiz.1_Missense_Mutation_p.E350K	NM_006239	NP_006230	O14830	PPE2_HUMAN	serine/threonine protein phosphatase with	350	Catalytic.				detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			ovary(2)|lung(1)|central_nervous_system(1)	4			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)															---	---	---	---
STBD1	8987	broad.mit.edu	37	4	77230640	77230640	+	Silent	SNP	C	T	T	rs115600175	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:77230640C>T	uc003hka.2	+	2	810	c.564C>T	c.(562-564)AGC>AGT	p.S188S	STBD1_uc003hjy.2_3'UTR|STBD1_uc011cbv.1_3'UTR|STBD1_uc011cbw.1_Silent_p.S39S	NM_003943	NP_003934	O95210	STBD1_HUMAN	starch binding domain 1	188	Cytoplasmic (Potential).				carbohydrate metabolic process|muscle contraction	integral to plasma membrane|membrane fraction	carbohydrate binding|catalytic activity|protein binding			ovary(1)	1			Lung(101;0.196)															---	---	---	---
CCDC158	339965	broad.mit.edu	37	4	77255321	77255321	+	Splice_Site	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:77255321C>T	uc003hkb.3	-	18	2818	c.2665_splice	c.e18-1	p.H889_splice		NM_001042784	NP_001036249			coiled-coil domain containing 158											skin(3)|ovary(2)|pancreas(1)	6																		---	---	---	---
ANKRD56	345079	broad.mit.edu	37	4	77816917	77816917	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:77816917G>A	uc003hki.2	-	1	2086	c.2086C>T	c.(2086-2088)CGG>TGG	p.R696W		NM_001029870	NP_001025041	A6NEL2	ANR56_HUMAN	ankyrin repeat domain 56	696	ANK 2.										0																		---	---	---	---
CCNI	10983	broad.mit.edu	37	4	77969731	77969731	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:77969731C>T	uc003hkm.2	-	7	1319	c.775G>A	c.(775-777)GTT>ATT	p.V259I	CCNI_uc011ccb.1_Missense_Mutation_p.V245I	NM_006835	NP_006826	Q14094	CCNI_HUMAN	cyclin I	259					spermatogenesis					ovary(1)	1																		---	---	---	---
PRKG2	5593	broad.mit.edu	37	4	82126113	82126113	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:82126113A>G	uc003hmh.2	-	1	103	c.89T>C	c.(88-90)GTG>GCG	p.V30A	PRKG2_uc011cch.1_Missense_Mutation_p.V30A	NM_006259	NP_006250	Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	30					platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			breast(3)|central_nervous_system(2)|ovary(1)|large_intestine(1)	7																		---	---	---	---
WDFY3	23001	broad.mit.edu	37	4	85704107	85704107	+	Intron	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:85704107T>C	uc003hpd.2	-							NM_014991	NP_055806			WD repeat and FYVE domain containing 3 isoform							cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)														---	---	---	---
SPP1	6696	broad.mit.edu	37	4	88903934	88903934	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:88903934A>T	uc003hra.2	+	7	996	c.831A>T	c.(829-831)GAA>GAT	p.E277D	SPP1_uc003hrb.2_Missense_Mutation_p.E250D|SPP1_uc003hrc.2_Missense_Mutation_p.E263D|SPP1_uc011cde.1_Missense_Mutation_p.E290D|SPP1_uc003hrd.2_Missense_Mutation_p.E236D	NM_001040058	NP_001035147	P10451	OSTP_HUMAN	secreted phosphoprotein 1 isoform a	277				SHEF -> GNSL (in Ref. 2).	biomineral tissue development|cell adhesion|decidualization|embryo implantation|ossification|response to vitamin D	extracellular space	cytokine activity			ovary(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-05)														---	---	---	---
ATOH1	474	broad.mit.edu	37	4	94750420	94750420	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:94750420A>G	uc003hta.1	+	1	343	c.343A>G	c.(343-345)AGC>GGC	p.S115G		NM_005172	NP_005163	Q92858	ATOH1_HUMAN	atonal homolog 1	115					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity				0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.57e-07)														---	---	---	---
CENPE	1062	broad.mit.edu	37	4	104065480	104065480	+	Intron	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:104065480T>C	uc003hxb.1	-						CENPE_uc003hxc.1_Intron	NM_001813	NP_001804			centromere protein E						blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)														---	---	---	---
CXXC4	80319	broad.mit.edu	37	4	105412064	105412064	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:105412064T>C	uc003hxg.2	-	1	404	c.389A>G	c.(388-390)AAC>AGC	p.N130S	uc003hxh.1_5'Flank|CXXC4_uc010ilo.2_Intron	NM_025212	NP_079488	Q9H2H0	CXXC4_HUMAN	CXXC finger 4	130					negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway|zygotic specification of dorsal/ventral axis		DNA binding|PDZ domain binding|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;3.05e-08)														---	---	---	---
PRDM5	11107	broad.mit.edu	37	4	121774642	121774642	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:121774642C>T	uc003idn.2	-	3	481	c.231G>A	c.(229-231)CGG>CGA	p.R77R	PRDM5_uc003ido.2_Silent_p.R77R|PRDM5_uc010ine.2_Silent_p.R77R|PRDM5_uc010inf.2_Silent_p.R77R|PRDM5_uc003idp.1_Silent_p.R77R	NM_018699	NP_061169	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	77	SET.				histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2																		---	---	---	---
C4orf31	79625	broad.mit.edu	37	4	121958294	121958294	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:121958294G>A	uc003idq.1	-	4	1359	c.832C>T	c.(832-834)CGT>TGT	p.R278C		NM_024574	NP_078850	Q8TB73	CD031_HUMAN	hypothetical protein LOC79625 precursor	278	Fibronectin type-III 1.										0																		---	---	---	---
C4orf31	79625	broad.mit.edu	37	4	121961098	121961098	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:121961098G>A	uc003idq.1	-	3	827	c.300C>T	c.(298-300)AGC>AGT	p.S100S		NM_024574	NP_078850	Q8TB73	CD031_HUMAN	hypothetical protein LOC79625 precursor	100											0																		---	---	---	---
FAT4	79633	broad.mit.edu	37	4	126239229	126239229	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:126239229C>T	uc003ifj.3	+	1	1663	c.1663C>T	c.(1663-1665)CGG>TGG	p.R555W		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	555	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18																OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
PCDH18	54510	broad.mit.edu	37	4	138452975	138452975	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:138452975C>T	uc003ihe.3	-	1	655	c.268G>A	c.(268-270)GCT>ACT	p.A90T	PCDH18_uc003ihf.3_Missense_Mutation_p.A83T|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_Intron|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	90	Extracellular (Potential).|Cadherin 1.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.A90T(1)		pancreas(3)|skin(2)	5	all_hematologic(180;0.24)																	---	---	---	---
KIAA0922	23240	broad.mit.edu	37	4	154523729	154523729	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:154523729G>A	uc003inm.3	+	23	2538	c.2486G>A	c.(2485-2487)CGG>CAG	p.R829Q	KIAA0922_uc010ipp.2_Missense_Mutation_p.R830Q|KIAA0922_uc010ipq.2_Missense_Mutation_p.R598Q	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	829	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)																---	---	---	---
DCHS2	54798	broad.mit.edu	37	4	155155840	155155840	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:155155840C>A	uc003inw.2	-	25	8599	c.8599G>T	c.(8599-8601)GAA>TAA	p.E2867*		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2867					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)														---	---	---	---
DCHS2	54798	broad.mit.edu	37	4	155157007	155157007	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:155157007C>A	uc003inw.2	-	25	7432	c.7432G>T	c.(7432-7434)GGA>TGA	p.G2478*		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2478	Cadherin 22.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)														---	---	---	---
ACCN5	51802	broad.mit.edu	37	4	156784774	156784774	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:156784774C>T	uc003ipe.1	-	2	220	c.173G>A	c.(172-174)AGC>AAC	p.S58N		NM_017419	NP_059115	Q9NY37	ACCN5_HUMAN	amiloride-sensitive cation channel 5,	58	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0464)|Kidney(143;0.058)|COAD - Colon adenocarcinoma(41;0.141)														---	---	---	---
PDGFC	56034	broad.mit.edu	37	4	157684333	157684333	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:157684333C>T	uc003iph.1	-	6	1438	c.947G>A	c.(946-948)GGT>GAT	p.G316D	PDGFC_uc003ipi.1_Missense_Mutation_p.G153D|PDGFC_uc011cis.1_Missense_Mutation_p.G153D|PDGFC_uc011cir.1_Missense_Mutation_p.G160D	NM_016205	NP_057289	Q9NRA1	PDGFC_HUMAN	platelet-derived growth factor C precursor	316					central nervous system development|platelet-derived growth factor receptor signaling pathway|positive regulation of cell division|positive regulation of DNA replication|positive regulation of fibroblast proliferation|vascular endothelial growth factor receptor signaling pathway	endoplasmic reticulum lumen|extracellular space|Golgi membrane|nucleus	cell surface binding|growth factor activity|platelet-derived growth factor receptor binding|protein homodimerization activity			ovary(1)|lung(1)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.08)|Kidney(143;0.0977)|COAD - Colon adenocarcinoma(41;0.212)														---	---	---	---
GRIA2	2891	broad.mit.edu	37	4	158262574	158262574	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:158262574A>G	uc003ipm.3	+	12	2462	c.2003A>G	c.(2002-2004)TAT>TGT	p.Y668C	GRIA2_uc011cit.1_Missense_Mutation_p.Y621C|GRIA2_uc003ipl.3_Missense_Mutation_p.Y668C|GRIA2_uc003ipk.3_Missense_Mutation_p.Y621C|GRIA2_uc010iqh.1_RNA	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	668	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)													---	---	---	---
FSTL5	56884	broad.mit.edu	37	4	162577602	162577602	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:162577602T>C	uc003iqh.2	-	7	1208	c.772A>G	c.(772-774)ACT>GCT	p.T258A	FSTL5_uc003iqi.2_Missense_Mutation_p.T257A|FSTL5_uc010iqv.2_Missense_Mutation_p.T257A	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	258	Ig-like 1.					extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)														---	---	---	---
KLHL2	11275	broad.mit.edu	37	4	166231877	166231877	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:166231877T>C	uc003irb.2	+	10	1471	c.1212T>C	c.(1210-1212)GCT>GCC	p.A404A	KLHL2_uc011cjm.1_Silent_p.A408A|KLHL2_uc003irc.2_Silent_p.A316A|KLHL2_uc010ira.2_Silent_p.A57A	NM_007246	NP_009177	O95198	KLHL2_HUMAN	kelch-like 2, Mayven isoform 1	404	Kelch 3.				intracellular protein transport	actin cytoskeleton|cytoplasm	actin binding|transporter activity				0	all_hematologic(180;0.221)			GBM - Glioblastoma multiforme(119;2.94e-27)|COAD - Colon adenocarcinoma(41;1.4e-05)|Kidney(143;4.95e-05)|KIRC - Kidney renal clear cell carcinoma(143;0.000927)														---	---	---	---
DDX60L	91351	broad.mit.edu	37	4	169351672	169351672	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:169351672C>T	uc003irq.3	-	13	1855	c.1634G>A	c.(1633-1635)CGG>CAG	p.R545Q	DDX60L_uc003irr.1_Missense_Mutation_p.R545Q|DDX60L_uc003irs.1_Missense_Mutation_p.R272Q	NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	545							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)														---	---	---	---
GALNTL6	442117	broad.mit.edu	37	4	173803946	173803946	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:173803946C>T	uc003isv.2	+	8	1665	c.929C>T	c.(928-930)CCT>CTT	p.P310L		NM_001034845	NP_001030017	Q49A17	GLTL6_HUMAN	N-acetylgalactosaminyltransferase-like 6	310	Catalytic subdomain B.|Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|ovary(1)|skin(1)	4																		---	---	---	---
DCTD	1635	broad.mit.edu	37	4	183815681	183815681	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:183815681A>C	uc003ivf.2	-	4	496	c.322T>G	c.(322-324)TTC>GTC	p.F108V	DCTD_uc003ivg.2_Missense_Mutation_p.F119V|DCTD_uc010irw.2_Missense_Mutation_p.F49V|DCTD_uc003ivh.2_Missense_Mutation_p.F49V	NM_001921	NP_001912	P32321	DCTD_HUMAN	dCMP deaminase isoform b	108					nucleotide biosynthetic process|pyrimidine base metabolic process|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide metabolic process	cytosol	dCMP deaminase activity|zinc ion binding				0		all_lung(41;5.16e-14)|Lung NSC(41;1.33e-13)|Colorectal(36;0.00666)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.202)		all cancers(43;1.65e-24)|Epithelial(43;3.44e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.39e-10)|Colorectal(24;4.69e-07)|COAD - Colon adenocarcinoma(29;7.07e-05)|STAD - Stomach adenocarcinoma(60;0.000118)|GBM - Glioblastoma multiforme(59;0.000472)|LUSC - Lung squamous cell carcinoma(40;0.00984)|READ - Rectum adenocarcinoma(43;0.0419)														---	---	---	---
C4orf41	60684	broad.mit.edu	37	4	184596387	184596387	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:184596387T>G	uc003ivx.2	+	7	907	c.731T>G	c.(730-732)CTG>CGG	p.L244R	C4orf41_uc003ivw.2_Missense_Mutation_p.L244R|C4orf41_uc010isc.2_Intron	NM_021942	NP_068761	Q7Z392	CD041_HUMAN	hypothetical protein LOC60684 isoform a	244											0		all_lung(41;4.4e-14)|Lung NSC(41;1.03e-13)|Colorectal(36;0.00139)|all_hematologic(60;0.00756)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.202)		all cancers(43;1.39e-26)|Epithelial(43;2.42e-22)|OV - Ovarian serous cystadenocarcinoma(60;6.85e-10)|GBM - Glioblastoma multiforme(59;6.71e-06)|Colorectal(24;9.67e-06)|STAD - Stomach adenocarcinoma(60;2.36e-05)|COAD - Colon adenocarcinoma(29;7.07e-05)|LUSC - Lung squamous cell carcinoma(40;0.00984)|READ - Rectum adenocarcinoma(43;0.171)														---	---	---	---
IRF2	3660	broad.mit.edu	37	4	185339729	185339729	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:185339729C>A	uc003iwf.3	-	4	521	c.321G>T	c.(319-321)AGG>AGT	p.R107S		NM_002199	NP_002190	P14316	IRF2_HUMAN	interferon regulatory factor 2	107	IRF tryptophan pentad repeat.				blood coagulation|cell proliferation|interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	focal adhesion|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		all_lung(41;7.86e-14)|Lung NSC(41;1.87e-13)|Colorectal(36;0.00146)|Hepatocellular(41;0.00826)|Renal(120;0.00992)|Prostate(90;0.0115)|all_neural(102;0.0573)|all_hematologic(60;0.0592)		all cancers(43;3.94e-27)|Epithelial(43;5.3e-24)|OV - Ovarian serous cystadenocarcinoma(60;1.06e-10)|Colorectal(24;7.98e-07)|STAD - Stomach adenocarcinoma(60;3.95e-05)|GBM - Glioblastoma multiforme(59;8.3e-05)|COAD - Colon adenocarcinoma(29;0.000106)|BRCA - Breast invasive adenocarcinoma(30;0.000311)|LUSC - Lung squamous cell carcinoma(40;0.0128)|READ - Rectum adenocarcinoma(43;0.0419)														---	---	---	---
LRP2BP	55805	broad.mit.edu	37	4	186295603	186295603	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:186295603C>A	uc003ixj.1	-	4	1155	c.343G>T	c.(343-345)GAC>TAC	p.D115Y	LRP2BP_uc003ixk.1_Missense_Mutation_p.D89Y|LRP2BP_uc011ckr.1_Missense_Mutation_p.D115Y	NM_018409	NP_060879	Q9P2M1	LR2BP_HUMAN	LRP2 binding protein	115	Sel1-like 1.					cytoplasm	protein binding				0		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;0.00109)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;2.14e-25)|Epithelial(43;1.55e-22)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-11)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.000132)|STAD - Stomach adenocarcinoma(60;0.000766)|Colorectal(24;0.00116)|LUSC - Lung squamous cell carcinoma(40;0.00904)|COAD - Colon adenocarcinoma(29;0.0101)|READ - Rectum adenocarcinoma(43;0.161)														---	---	---	---
CCDC110	256309	broad.mit.edu	37	4	186380474	186380474	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:186380474G>A	uc003ixu.3	-	6	1343	c.1267C>T	c.(1267-1269)CAG>TAG	p.Q423*	CCDC110_uc003ixv.3_Nonsense_Mutation_p.Q386*|CCDC110_uc011ckt.1_Nonsense_Mutation_p.Q423*	NM_152775	NP_689988	Q8TBZ0	CC110_HUMAN	coiled-coil domain containing 110 isoform a	423						nucleus				central_nervous_system(1)	1		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;7.86e-05)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|Colorectal(36;0.0381)|all_hematologic(60;0.0749)		OV - Ovarian serous cystadenocarcinoma(60;1.13e-10)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.00014)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00921)|COAD - Colon adenocarcinoma(29;0.0105)|READ - Rectum adenocarcinoma(43;0.164)														---	---	---	---
FAM149A	25854	broad.mit.edu	37	4	187075716	187075716	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:187075716C>T	uc003iyt.3	+	6	886	c.307C>T	c.(307-309)CGT>TGT	p.R103C	FAM149A_uc011cla.1_Missense_Mutation_p.R103C|FAM149A_uc010isj.2_Missense_Mutation_p.R103C|FAM149A_uc010isk.2_RNA|FAM149A_uc003iyu.3_Missense_Mutation_p.R103C|FAM149A_uc010isl.2_Missense_Mutation_p.R103C|FAM149A_uc011clb.1_Missense_Mutation_p.R103C	NM_015398	NP_056213	A5PLN7	F149A_HUMAN	hypothetical protein LOC25854	394										breast(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.19e-10)|BRCA - Breast invasive adenocarcinoma(30;1.22e-05)|GBM - Glioblastoma multiforme(59;0.000122)|STAD - Stomach adenocarcinoma(60;0.000288)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.166)														---	---	---	---
KLKB1	3818	broad.mit.edu	37	4	187171481	187171481	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:187171481G>T	uc003iyy.2	+	7	754	c.683G>T	c.(682-684)CGG>CTG	p.R228L	KLKB1_uc011clc.1_Nonsense_Mutation_p.G16*|KLKB1_uc011cld.1_Missense_Mutation_p.R190L	NM_000892	NP_000883	P03952	KLKB1_HUMAN	plasma kallikrein B1 precursor	228	Apple 3.				blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			ovary(1)	1		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)														---	---	---	---
KLKB1	3818	broad.mit.edu	37	4	187173268	187173268	+	Silent	SNP	T	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:187173268T>G	uc003iyy.2	+	11	1313	c.1242T>G	c.(1240-1242)GCT>GCG	p.A414A	KLKB1_uc011clc.1_Silent_p.A212A|KLKB1_uc011cld.1_Silent_p.A376A	NM_000892	NP_000883	P03952	KLKB1_HUMAN	plasma kallikrein B1 precursor	414	Peptidase S1.				blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			ovary(1)	1		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)														---	---	---	---
F11	2160	broad.mit.edu	37	4	187194215	187194215	+	Intron	SNP	A	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:187194215A>T	uc003iza.1	+						F11_uc003iyz.2_Intron	NM_000128	NP_000119			coagulation factor XI precursor						blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity				0		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)													---	---	---	---
FAT1	2195	broad.mit.edu	37	4	187509854	187509854	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:187509854G>A	uc003izf.2	-	27	13847	c.13659C>T	c.(13657-13659)TGC>TGT	p.C4553C	FAT1_uc010isn.2_Silent_p.C200C|FAT1_uc003ize.2_Silent_p.C444C	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	4553	Cytoplasmic (Potential).				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12															HNSCC(5;0.00058)			---	---	---	---
KIAA0947	23379	broad.mit.edu	37	5	5464464	5464464	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:5464464C>T	uc003jdm.3	+	13	5239	c.5017C>T	c.(5017-5019)CGT>TGT	p.R1673C		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	1673	Pro-rich.									ovary(1)|central_nervous_system(1)	2																		---	---	---	---
PAPD7	11044	broad.mit.edu	37	5	6742688	6742688	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:6742688A>T	uc003jdx.1	+	5	473	c.344A>T	c.(343-345)GAG>GTG	p.E115V	PAPD7_uc011cmn.1_Missense_Mutation_p.E106V	NM_006999	NP_008930	Q5XG87	PAPD7_HUMAN	DNA polymerase sigma	115					cell division|DNA replication|double-strand break repair|mitotic chromosome condensation|response to drug|sister chromatid cohesion	nucleus	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|SMC protein binding			ovary(1)	1																		---	---	---	---
ADCY2	108	broad.mit.edu	37	5	7414769	7414769	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:7414769C>T	uc003jdz.1	+	2	361	c.294C>T	c.(292-294)ATC>ATT	p.I98I		NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	98					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7																		---	---	---	---
MTRR	4552	broad.mit.edu	37	5	7892923	7892923	+	Missense_Mutation	SNP	G	A	A	rs146475928	byFrequency	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:7892923G>A	uc003jed.2	+	11	1565	c.1535G>A	c.(1534-1536)CGG>CAG	p.R512Q	MTRR_uc003jee.3_Missense_Mutation_p.R485Q|MTRR_uc003jef.3_RNA|MTRR_uc003jeg.3_RNA|MTRR_uc010ito.2_RNA	NM_024010	NP_076915	Q9UBK8	MTRR_HUMAN	methionine synthase reductase isoform 2	512	FAD-binding FR-type.				methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			ovary(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)													---	---	---	---
CTNND2	1501	broad.mit.edu	37	5	11082809	11082809	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:11082809G>A	uc003jfa.1	-	16	2932	c.2787C>T	c.(2785-2787)ATC>ATT	p.I929I	CTNND2_uc010itt.2_Silent_p.I838I|CTNND2_uc011cmy.1_Silent_p.I592I|CTNND2_uc011cmz.1_Silent_p.I496I|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Silent_p.I521I	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	929					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8																		---	---	---	---
MYO10	4651	broad.mit.edu	37	5	16711279	16711279	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:16711279G>A	uc003jft.3	-	20	2473	c.2005C>T	c.(2005-2007)CGC>TGC	p.R669C	MYO10_uc011cnd.1_Missense_Mutation_p.R26C|MYO10_uc011cne.1_Missense_Mutation_p.R26C|MYO10_uc010itx.2_Missense_Mutation_p.R292C	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	669	Myosin head-like.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3																		---	---	---	---
ZFR	51663	broad.mit.edu	37	5	32406984	32406984	+	Silent	SNP	A	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:32406984A>T	uc003jhr.1	-	6	1007	c.927T>A	c.(925-927)ACT>ACA	p.T309T	ZFR_uc010iun.1_Silent_p.T309T	NM_016107	NP_057191	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	309					multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding				0				STAD - Stomach adenocarcinoma(35;0.19)														---	---	---	---
RXFP3	51289	broad.mit.edu	37	5	33937420	33937420	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:33937420G>A	uc003jic.1	+	1	932	c.575G>A	c.(574-576)CGG>CAG	p.R192Q		NM_016568	NP_057652	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	192	Cytoplasmic (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1																		---	---	---	---
UGT3A1	133688	broad.mit.edu	37	5	35955903	35955903	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:35955903C>T	uc003jjv.1	-	6	1296	c.1139G>A	c.(1138-1140)CGT>CAT	p.R380H	UGT3A1_uc003jjw.1_RNA|UGT3A1_uc011coq.1_Missense_Mutation_p.R380H|UGT3A1_uc011cor.1_Missense_Mutation_p.R346H	NM_152404	NP_689617	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	380	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|central_nervous_system(1)	3	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)															---	---	---	---
RICTOR	253260	broad.mit.edu	37	5	38942984	38942984	+	Missense_Mutation	SNP	G	A	A	rs77464125	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:38942984G>A	uc003jlp.2	-	37	5027	c.5003C>T	c.(5002-5004)CCG>CTG	p.P1668L	RICTOR_uc003jlo.2_Missense_Mutation_p.P1692L|RICTOR_uc010ivf.2_Missense_Mutation_p.P1345L	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	1668					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)																	---	---	---	---
CARD6	84674	broad.mit.edu	37	5	40853916	40853916	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:40853916G>A	uc003jmg.2	+	3	2557	c.2482G>A	c.(2482-2484)GCC>ACC	p.A828T		NM_032587	NP_115976	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	828					apoptosis|regulation of apoptosis	intracellular				ovary(2)|skin(2)|lung(1)	5																		---	---	---	---
DHX29	54505	broad.mit.edu	37	5	54573111	54573111	+	Splice_Site	SNP	C	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:54573111C>G	uc003jpx.2	-	13	2230	c.2110_splice	c.e13-1	p.V704_splice	DHX29_uc010ivw.2_Splice_Site	NM_019030	NP_061903			DEAH (Asp-Glu-Ala-His) box polypeptide 29								ATP binding|ATP-dependent helicase activity|translation initiation factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)																---	---	---	---
PDE4D	5144	broad.mit.edu	37	5	58295328	58295328	+	Intron	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:58295328C>A	uc003jsa.2	-						PDE4D_uc003jrx.2_Intron|PDE4D_uc003jry.2_Intron|PDE4D_uc003jrz.2_Intron|PDE4D_uc003jsb.2_Intron|PDE4D_uc003jrt.2_Intron|PDE4D_uc003jru.2_Intron|PDE4D_uc003jrv.2_Intron|PDE4D_uc003jrw.2_Intron|PDE4D_uc010iwi.1_Intron|PDE4D_uc003jrs.2_Missense_Mutation_p.W12C	NM_001104631	NP_001098101			phosphodiesterase 4D isoform 1						signal transduction	cytosol|insoluble fraction|membrane|microtubule organizing center|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(5;6.5e-58)|all_epithelial(5;1.75e-57)|all_lung(5;6.84e-18)|Lung NSC(5;1.29e-17)|Melanoma(5;0.00168)|Prostate(74;0.00234)|Colorectal(97;0.00629)|Ovarian(174;0.00832)|Breast(144;0.00996)|all_hematologic(6;0.0344)|Hepatocellular(6;0.0742)|Esophageal squamous(6;0.0954)		Epithelial(2;2.6e-55)|all cancers(2;2.66e-49)|OV - Ovarian serous cystadenocarcinoma(10;1.48e-39)|Colorectal(2;8.29e-08)|Lung(2;4.47e-07)|STAD - Stomach adenocarcinoma(2;1.11e-05)|COAD - Colon adenocarcinoma(2;0.00012)|LUSC - Lung squamous cell carcinoma(2;0.000775)|LUAD - Lung adenocarcinoma(3;0.0173)|READ - Rectum adenocarcinoma(2;0.0276)	Adenosine monophosphate(DB00131)|Dyphylline(DB00651)													---	---	---	---
SLC30A5	64924	broad.mit.edu	37	5	68417584	68417584	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:68417584A>G	uc003jvh.2	+	13	1834	c.1633A>G	c.(1633-1635)AGC>GGC	p.S545G	SLC30A5_uc003jvj.2_RNA|SLC30A5_uc003jvk.2_Missense_Mutation_p.S274G|SLC30A5_uc003jvi.2_Missense_Mutation_p.S374G	NM_022902	NP_075053	Q8TAD4	ZNT5_HUMAN	solute carrier family 30 (zinc transporter),	545	Cytoplasmic (Potential).|His-rich loop.				cellular zinc ion homeostasis|cobalt ion transport|regulation of proton transport|response to zinc ion	apical plasma membrane|Golgi apparatus|integral to plasma membrane|membrane fraction|secretory granule membrane	zinc ion binding|zinc ion transmembrane transporter activity			central_nervous_system(1)	1		Lung NSC(167;0.000986)|Prostate(74;0.00809)|Colorectal(97;0.0508)|Ovarian(174;0.16)		OV - Ovarian serous cystadenocarcinoma(47;1.24e-56)|Epithelial(20;1.12e-52)|all cancers(19;2.63e-48)|Lung(70;0.0177)														---	---	---	---
BDP1	55814	broad.mit.edu	37	5	70805815	70805815	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:70805815C>A	uc003kbp.1	+	17	3159	c.2896C>A	c.(2896-2898)CCA>ACA	p.P966T	BDP1_uc003kbn.1_Missense_Mutation_p.P966T|BDP1_uc003kbo.2_Missense_Mutation_p.P966T	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	966	3.|9 X 55 AA repeats of G-R-R-X-I-S-P-X-E-N- G-X-E-E-V-K-P-X-X-E-M-E-T-D-L-K-X-T-G-R- E-X-X-X-R-E-K-T-X-E-X-X-D-A-X-E-E-I-D-X- D-L-E-E-T.				regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)														---	---	---	---
CRHBP	1393	broad.mit.edu	37	5	76264715	76264715	+	3'UTR	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:76264715C>T	uc003ker.2	+	7						NM_001882	NP_001873			corticotropin releasing hormone binding protein						female pregnancy|learning or memory|signal transduction	soluble fraction					0		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-51)|Epithelial(54;8.79e-46)|all cancers(79;2.49e-41)														---	---	---	---
AP3B1	8546	broad.mit.edu	37	5	77536745	77536745	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:77536745T>C	uc003kfj.2	-	3	345	c.220A>G	c.(220-222)AAA>GAA	p.K74E		NM_003664	NP_003655	O00203	AP3B1_HUMAN	adaptor-related protein complex 3, beta 1	74					endocytosis|melanosome organization	clathrin coated vesicle membrane|Golgi apparatus|membrane coat	protein phosphatase binding|protein transporter activity			central_nervous_system(1)	1		all_lung(232;0.000397)|Lung NSC(167;0.00106)|Ovarian(174;0.0105)|Prostate(461;0.215)		OV - Ovarian serous cystadenocarcinoma(54;8.23e-47)|Epithelial(54;2.74e-41)|all cancers(79;4.8e-36)										Hermansky-Pudlak_syndrome				---	---	---	---
VCAN	1462	broad.mit.edu	37	5	82835880	82835880	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:82835880C>T	uc003kii.3	+	8	7414	c.7058C>T	c.(7057-7059)ACG>ATG	p.T2353M	VCAN_uc003kij.3_Missense_Mutation_p.T1366M|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Missense_Mutation_p.T1017M	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	2353	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)														---	---	---	---
VCAN	1462	broad.mit.edu	37	5	82850774	82850774	+	Splice_Site	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:82850774G>T	uc003kii.3	+	12	10009	c.9653_splice	c.e12-1	p.R3218_splice	VCAN_uc003kij.3_Splice_Site_p.R2231_splice|VCAN_uc010jau.2_Splice_Site_p.R1464_splice|VCAN_uc003kik.3_Splice_Site_p.R477_splice|VCAN_uc003kil.3_Splice_Site_p.R1882_splice	NM_004385	NP_004376			versican isoform 1 precursor						cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)														---	---	---	---
RASA1	5921	broad.mit.edu	37	5	86659293	86659293	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:86659293T>C	uc003kiw.2	+	11	1700	c.1582T>C	c.(1582-1584)TAT>CAT	p.Y528H	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_Missense_Mutation_p.Y351H|RASA1_uc011ctv.1_Missense_Mutation_p.Y361H|RASA1_uc011ctw.1_Missense_Mutation_p.Y362H|RASA1_uc010jaw.2_Missense_Mutation_p.Y350H	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	528	PH.				cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)														---	---	---	---
GPR98	84059	broad.mit.edu	37	5	89939634	89939634	+	Nonsense_Mutation	SNP	C	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:89939634C>G	uc003kju.2	+	14	2664	c.2568C>G	c.(2566-2568)TAC>TAG	p.Y856*	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	856	Extracellular (Potential).|Calx-beta 6.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)														---	---	---	---
GPR98	84059	broad.mit.edu	37	5	89939651	89939651	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:89939651G>T	uc003kju.2	+	14	2681	c.2585G>T	c.(2584-2586)AGC>ATC	p.S862I	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	862	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)														---	---	---	---
GPR98	84059	broad.mit.edu	37	5	89949768	89949768	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:89949768C>T	uc003kju.2	+	20	4473	c.4377C>T	c.(4375-4377)GAC>GAT	p.D1459D	GPR98_uc003kjt.2_Translation_Start_Site	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	1459	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)														---	---	---	---
TTC37	9652	broad.mit.edu	37	5	94863861	94863861	+	Intron	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:94863861C>T	uc003klb.2	-						TTC37_uc010jbf.1_Intron	NM_014639	NP_055454			tetratricopeptide repeat domain 37								binding			ovary(3)|pancreas(1)	4																		---	---	---	---
SLCO6A1	133482	broad.mit.edu	37	5	101813576	101813576	+	Intron	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:101813576T>C	uc003knn.2	-						SLCO6A1_uc003kno.2_Intron|SLCO6A1_uc003knp.2_Intron|SLCO6A1_uc003knq.2_Intron	NM_173488	NP_775759			solute carrier organic anion transporter family,							integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)														---	---	---	---
DCP2	167227	broad.mit.edu	37	5	112327834	112327834	+	Silent	SNP	G	A	A	rs144025307		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:112327834G>A	uc003kqh.2	+	3	420	c.222G>A	c.(220-222)CCG>CCA	p.P74P	DCP2_uc011cwa.1_Intron|DCP2_uc010jcc.2_5'UTR	NM_152624	NP_689837	Q8IU60	DCP2_HUMAN	DCP2 decapping enzyme	74					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasmic mRNA processing body|cytosol|nucleus|RNA-induced silencing complex	exoribonuclease activity, producing 5'-phosphomonoesters|manganese ion binding|protein binding|protein binding|RNA binding				0		all_cancers(142;4.41e-05)|all_epithelial(76;3.65e-07)|Colorectal(10;0.00115)|Prostate(80;0.00133)|Ovarian(225;0.0443)		OV - Ovarian serous cystadenocarcinoma(64;6.98e-08)|Epithelial(69;7.87e-08)|all cancers(49;1.06e-05)|COAD - Colon adenocarcinoma(37;0.0123)|Colorectal(14;0.0171)														---	---	---	---
PGGT1B	5229	broad.mit.edu	37	5	114573623	114573623	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:114573623G>A	uc003kqw.3	-	4	432	c.411C>T	c.(409-411)GAC>GAT	p.D137D	PGGT1B_uc003kqx.3_Silent_p.D14D|PGGT1B_uc010jch.2_Silent_p.D137D	NM_005023	NP_005014	P53609	PGTB1_HUMAN	geranylgeranyltransferase type 1 beta	137					protein geranylgeranylation	CAAX-protein geranylgeranyltransferase complex	CAAX-protein geranylgeranyltransferase activity				0		all_cancers(142;0.000523)|all_epithelial(76;6.45e-06)|Prostate(80;0.00955)|Ovarian(225;0.0443)|all_lung(232;0.132)|Breast(839;0.195)		Epithelial(69;2.95e-08)|OV - Ovarian serous cystadenocarcinoma(64;4.98e-08)|all cancers(49;3.1e-06)	Pravastatin(DB00175)													---	---	---	---
DMXL1	1657	broad.mit.edu	37	5	118486082	118486082	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:118486082C>T	uc003ksd.2	+	18	4741	c.4560C>T	c.(4558-4560)AGC>AGT	p.S1520S	DMXL1_uc010jcl.1_Silent_p.S1520S	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1520										ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)														---	---	---	---
CEP120	153241	broad.mit.edu	37	5	122734964	122734964	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:122734964C>T	uc003ktk.2	-	6	560	c.478G>A	c.(478-480)GCT>ACT	p.A160T	CEP120_uc011cwq.1_5'UTR|CEP120_uc010jcz.1_Missense_Mutation_p.A134T	NM_153223	NP_694955	Q8N960	CE120_HUMAN	coiled-coil domain containing 100	160						centrosome				ovary(1)	1																		---	---	---	---
FBN2	2201	broad.mit.edu	37	5	127800499	127800499	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:127800499G>A	uc003kuu.2	-	6	1183	c.744C>T	c.(742-744)GGC>GGT	p.G248G	FBN2_uc003kuv.2_Silent_p.G215G|FBN2_uc003kuw.3_Silent_p.G248G|FBN2_uc003kux.1_Silent_p.G248G	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	248	TB 1.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)														---	---	---	---
ADAMTS19	171019	broad.mit.edu	37	5	129070744	129070744	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:129070744C>T	uc003kvb.1	+	22	3414	c.3414C>T	c.(3412-3414)TGC>TGT	p.C1138C	ADAMTS19_uc010jdh.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1138	TSP type-1 5.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)														---	---	---	---
TXNDC15	79770	broad.mit.edu	37	5	134235216	134235216	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:134235216C>T	uc003lac.1	+	5	1582	c.924C>T	c.(922-924)GCC>GCT	p.A308A	TXNDC15_uc010jdy.1_RNA|TXNDC15_uc011cxv.1_RNA	NM_024715	NP_078991	Q96J42	TXD15_HUMAN	disulfide isomerase precursor	308	Extracellular (Potential).				cell redox homeostasis	integral to membrane				ovary(1)|breast(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)															---	---	---	---
TGFBI	7045	broad.mit.edu	37	5	135385251	135385251	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:135385251G>A	uc003lbf.3	+	7	1056	c.895G>A	c.(895-897)GAC>AAC	p.D299N	TGFBI_uc003lbg.3_Missense_Mutation_p.D32N|TGFBI_uc003lbh.3_Missense_Mutation_p.D125N|TGFBI_uc011cyb.1_Missense_Mutation_p.D125N|TGFBI_uc010jed.2_Missense_Mutation_p.D32N	NM_000358	NP_000349	Q15582	BGH3_HUMAN	transforming growth factor, beta-induced, 68kDa	299	FAS1 2.				angiogenesis|cell adhesion|cell proliferation|negative regulation of cell adhesion|response to stimulus|visual perception	extracellular space|proteinaceous extracellular matrix	integrin binding			breast(3)|ovary(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)															---	---	---	---
SMAD5	4090	broad.mit.edu	37	5	135513177	135513177	+	3'UTR	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:135513177T>C	uc003lbj.1	+	11					SMAD5_uc003lbk.1_3'UTR|SMAD5_uc003lbl.1_3'UTR	NM_001001419	NP_001001419			SMAD family member 5						BMP signaling pathway|embryonic pattern specification|positive regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytosol|integral to membrane|transcription factor complex	sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)															---	---	---	---
BRD8	10902	broad.mit.edu	37	5	137486467	137486467	+	Silent	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:137486467A>G	uc003lcf.1	-	22	3142	c.3087T>C	c.(3085-3087)TGT>TGC	p.C1029C	BRD8_uc003lcc.1_Intron	NM_139199	NP_631938	Q9H0E9	BRD8_HUMAN	bromodomain containing 8 isoform 2	1029					cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)															---	---	---	---
GFRA3	2676	broad.mit.edu	37	5	137600037	137600037	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:137600037G>A	uc003lcn.2	-	2	432	c.292C>T	c.(292-294)CTG>TTG	p.L98L	GFRA3_uc003lco.2_Silent_p.L98L	NM_001496	NP_001487	O60609	GFRA3_HUMAN	GDNF family receptor alpha 3 preproprotein	98					peripheral nervous system development	anchored to membrane|cytoplasm|extrinsic to membrane|intracellular membrane-bounded organelle	receptor binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)															---	---	---	---
SLC23A1	9963	broad.mit.edu	37	5	138715466	138715466	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:138715466C>T	uc003leh.2	-	8	923	c.826G>A	c.(826-828)GTG>ATG	p.V276M	SLC23A1_uc003leg.2_Missense_Mutation_p.V280M	NM_005847	NP_005838	Q9UHI7	S23A1_HUMAN	solute carrier family 23 (nucleobase	276					brain development|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|response to toxin|transepithelial L-ascorbic acid transport|water-soluble vitamin metabolic process	apical plasma membrane|cytoplasm|integral to plasma membrane|intracellular organelle|membrane fraction	dehydroascorbic acid transporter activity|L-ascorbate:sodium symporter activity|nucleobase transmembrane transporter activity|protein binding|sodium-dependent L-ascorbate transmembrane transporter activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)		Vitamin C(DB00126)													---	---	---	---
PSD2	84249	broad.mit.edu	37	5	139197119	139197119	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:139197119C>T	uc003leu.1	+	5	1275	c.1070C>T	c.(1069-1071)TCG>TTG	p.S357L		NM_032289	NP_115665	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	357	SEC7.				regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
C5orf32	84418	broad.mit.edu	37	5	139574044	139574044	+	5'UTR	SNP	G	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:139574044G>C	uc003lfd.2	+	2					C5orf32_uc010jfi.2_Intron	NM_032412	NP_115788			hypothetical protein LOC84418												0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHA3	56145	broad.mit.edu	37	5	140182832	140182832	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140182832G>A	uc003lhf.2	+	1	2050	c.2050G>A	c.(2050-2052)GCT>ACT	p.A684T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Missense_Mutation_p.A684T	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	684	Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHA4	56144	broad.mit.edu	37	5	140189048	140189048	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140189048G>A	uc003lhi.2	+	1	2377	c.2276G>A	c.(2275-2277)TGC>TAC	p.C759Y	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Missense_Mutation_p.C759Y|PCDHA4_uc011daa.1_Missense_Mutation_p.C759Y	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	759	Cytoplasmic (Potential).|6 X 4 AA repeats of P-X-X-P.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHA5	56143	broad.mit.edu	37	5	140203040	140203040	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140203040C>T	uc003lhl.2	+	1	1680	c.1680C>T	c.(1678-1680)AAC>AAT	p.N560N	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Silent_p.N560N|PCDHA5_uc003lhj.1_Silent_p.N560N	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	560	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHA5	56143	broad.mit.edu	37	5	140203226	140203226	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140203226C>T	uc003lhl.2	+	1	1866	c.1866C>T	c.(1864-1866)CGC>CGT	p.R622R	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Silent_p.R622R|PCDHA5_uc003lhj.1_Silent_p.R622R	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	622	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHA13	56136	broad.mit.edu	37	5	140262616	140262616	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140262616G>A	uc003lif.2	+	1	763	c.763G>A	c.(763-765)GCC>ACC	p.A255T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.A255T|PCDHA13_uc003lid.2_Missense_Mutation_p.A255T	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	255	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHB6	56130	broad.mit.edu	37	5	140530204	140530204	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140530204C>T	uc003lir.2	+	1	366	c.366C>T	c.(364-366)GTC>GTT	p.V122V	PCDHB6_uc011dah.1_5'UTR	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	122	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)															---	---	---	---
PCDHB12	56124	broad.mit.edu	37	5	140588928	140588928	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140588928C>T	uc003liz.2	+	1	638	c.449C>T	c.(448-450)GCT>GTT	p.A150V	PCDHB12_uc011dak.1_Intron	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	150	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)															---	---	---	---
PCDHGB1	56104	broad.mit.edu	37	5	140730469	140730469	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140730469C>T	uc003ljo.1	+	1	642	c.642C>T	c.(640-642)GGC>GGT	p.G214G	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc011daq.1_Silent_p.G214G	NM_018922	NP_061745	Q9Y5G3	PCDGD_HUMAN	protocadherin gamma subfamily B, 1 isoform 1	214	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHGA6	56109	broad.mit.edu	37	5	140753737	140753737	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140753737G>A	uc003ljy.1	+	1	87	c.87G>A	c.(85-87)GCG>GCA	p.A29A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Silent_p.A29A	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	29					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHGA8	9708	broad.mit.edu	37	5	140773115	140773115	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140773115G>A	uc003lkd.1	+	1	1633	c.735G>A	c.(733-735)CCG>CCA	p.P245P	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkb.3_Silent_p.P245P	NM_032088	NP_114477	Q9Y5G5	PCDG8_HUMAN	protocadherin gamma subfamily A, 8 isoform 1	245	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHGB7	56099	broad.mit.edu	37	5	140799314	140799314	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140799314C>T	uc003lkn.1	+	1	2033	c.1888C>T	c.(1888-1890)CGT>TGT	p.R630C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkm.2_Missense_Mutation_p.R630C|PCDHGA11_uc003lko.1_5'Flank|PCDHGA11_uc003lkp.1_5'Flank|PCDHGA11_uc003lkq.1_5'Flank	NM_018927	NP_061750	Q9Y5F8	PCDGJ_HUMAN	protocadherin gamma subfamily B, 7 isoform 1	630	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
KIAA0141	9812	broad.mit.edu	37	5	141309272	141309272	+	Nonsense_Mutation	SNP	A	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:141309272A>T	uc003lls.2	+	5	660	c.538A>T	c.(538-540)AGA>TGA	p.R180*	KIAA0141_uc003llt.2_Nonsense_Mutation_p.R180*	NM_001142603	NP_001136075	Q14154	DELE_HUMAN	hypothetical protein LOC9812 precursor	180					apoptosis|regulation of caspase activity	mitochondrion	protein binding			skin(1)	1		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
SPRY4	81848	broad.mit.edu	37	5	141694197	141694197	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:141694197G>A	uc003lml.2	-	2	736	c.477C>T	c.(475-477)TGC>TGT	p.C159C	SPRY4_uc010jgi.1_Silent_p.C182C	NM_001127496	NP_001120968	Q9C004	SPY4_HUMAN	sprouty homolog 4 isoform 2	159	Cys-rich.				multicellular organismal development	cytoplasm|ruffle membrane	protein binding			ovary(1)|lung(1)	2		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)											Testicular_Cancer_Familial_Clustering_of				---	---	---	---
POU4F3	5459	broad.mit.edu	37	5	145719822	145719822	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:145719822C>T	uc003loa.2	+	2	921	c.832C>T	c.(832-834)CGC>TGC	p.R278C		NM_002700	NP_002691	Q15319	PO4F3_HUMAN	POU class 4 homeobox 3	278	Homeobox.				sensory perception of sound|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)															---	---	---	---
AFAP1L1	134265	broad.mit.edu	37	5	148697298	148697298	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:148697298T>C	uc003lqh.2	+	12	1405	c.1274T>C	c.(1273-1275)CTG>CCG	p.L425P	AFAP1L1_uc010jgy.2_Missense_Mutation_p.L425P|AFAP1L1_uc003lqi.1_Missense_Mutation_p.L40P	NM_152406	NP_689619	Q8TED9	AF1L1_HUMAN	actin filament associated protein 1-like 1	425	PH 2.						protein binding			breast(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)													OREG0016911	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
CSF1R	1436	broad.mit.edu	37	5	149435774	149435774	+	Intron	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:149435774G>T	uc003lrl.2	-						CSF1R_uc011dcd.1_Intron|CSF1R_uc010jhc.2_Intron|CSF1R_uc003lrm.2_Intron	NM_005211	NP_005202			colony stimulating factor 1 receptor precursor						cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			haematopoietic_and_lymphoid_tissue(38)|lung(6)|central_nervous_system(3)|liver(3)|breast(2)|endometrium(1)|ovary(1)	54			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)													---	---	---	---
PDGFRB	5159	broad.mit.edu	37	5	149502704	149502704	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:149502704C>T	uc003lro.2	-	15	2553	c.2084G>A	c.(2083-2085)CGC>CAC	p.R695H	PDGFRB_uc010jhd.2_Missense_Mutation_p.R534H	NM_002609	NP_002600	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor beta	695	Cytoplasmic (Potential).|Protein kinase.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			central_nervous_system(4)|lung(4)|breast(3)|stomach(2)|prostate(2)|large_intestine(1)|ovary(1)	17		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)			T	ETV6|TRIP11|HIP1|RAB5EP|H4|NIN|HCMOGT-1|PDE4DIP	MPD|AML|CMML|CML								---	---	---	---
G3BP1	10146	broad.mit.edu	37	5	151179857	151179857	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:151179857G>A	uc003lun.2	+	10	1205	c.1034G>A	c.(1033-1035)GGC>GAC	p.G345D	G3BP1_uc003lum.2_Missense_Mutation_p.G345D|G3BP1_uc011dcu.1_Missense_Mutation_p.G163D|G3BP1_uc010jhz.2_Missense_Mutation_p.G163D|G3BP1_uc003luq.2_Missense_Mutation_p.G13D	NM_005754	NP_005745	Q13283	G3BP1_HUMAN	Ras-GTPase-activating protein SH3-domain-binding	345	RRM.				Ras protein signal transduction|transport	cytosol|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|endonuclease activity|protein binding|RNA binding			skin(3)|ovary(1)	4		all_hematologic(541;0.0338)|Medulloblastoma(196;0.091)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)															---	---	---	---
PTTG1	9232	broad.mit.edu	37	5	159855606	159855606	+	Intron	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:159855606T>C	uc003lyj.2	+						PTTG1_uc003lyk.2_Intron	NM_004219	NP_004210			pituitary tumor-transforming protein 1						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|chromosome organization|chromosome segregation|DNA repair|mitosis|spermatogenesis|transcription from RNA polymerase II promoter	cytosol|nucleus	cysteine-type endopeptidase inhibitor activity|sequence-specific DNA binding transcription factor activity|SH3 domain binding				0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	OV - Ovarian serous cystadenocarcinoma(192;0.00219)|Epithelial(171;0.00348)|all cancers(165;0.0104)														---	---	---	---
GABRG2	2566	broad.mit.edu	37	5	161524835	161524835	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:161524835G>A	uc003lyz.3	+	4	877	c.519G>A	c.(517-519)TGG>TGA	p.W173*	GABRG2_uc010jjc.2_Nonsense_Mutation_p.W173*|GABRG2_uc003lyy.3_Nonsense_Mutation_p.W173*|GABRG2_uc011dej.1_Nonsense_Mutation_p.W78*	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	173	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)														---	---	---	---
DOCK2	1794	broad.mit.edu	37	5	169477281	169477281	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:169477281G>A	uc003maf.2	+	41	4173	c.4093G>A	c.(4093-4095)GGG>AGG	p.G1365R	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.G857R	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1365	DHR-2.|Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)															---	---	---	---
HRH2	3274	broad.mit.edu	37	5	175110616	175110616	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:175110616C>A	uc003mdd.2	+	1	2153	c.380C>A	c.(379-381)CCT>CAT	p.P127H	HRH2_uc003mdc.3_Missense_Mutation_p.P127H	NM_022304	NP_071640	P25021	HRH2_HUMAN	histamine receptor H2 isoform 2	127	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|immune response	integral to plasma membrane	histamine receptor activity			ovary(1)	1	all_cancers(89;0.00805)|Renal(175;0.000269)|Lung NSC(126;0.00419)|all_lung(126;0.00711)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)	Colorectal(1;0.0154)|COAD - Colon adenocarcinoma(1;0.149)	Betazole(DB00272)|Cimetidine(DB00501)|Doxepin(DB01142)|Epinastine(DB00751)|Famotidine(DB00927)|Histamine Phosphate(DB00667)|Nizatidine(DB00585)|Ranitidine(DB00863)													---	---	---	---
CDHR2	54825	broad.mit.edu	37	5	176004529	176004529	+	Missense_Mutation	SNP	G	A	A	rs114930966	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:176004529G>A	uc003mem.1	+	13	1390	c.1324G>A	c.(1324-1326)GAG>AAG	p.E442K	CDHR2_uc003men.1_Missense_Mutation_p.E442K	NM_017675	NP_060145	Q9BYE9	CDHR2_HUMAN	protocadherin LKC precursor	442	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			ovary(2)	2																		---	---	---	---
SNCB	6620	broad.mit.edu	37	5	176056582	176056582	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:176056582C>T	uc003mep.2	-	3	517	c.74G>A	c.(73-75)GGG>GAG	p.G25E	SNCB_uc003meq.2_Missense_Mutation_p.G25E|SNCB_uc010jke.1_Missense_Mutation_p.G25E|hsa-mir-4281|MI0015885_5'Flank|EIF4E1B_uc010jkf.1_5'Flank	NM_001001502	NP_001001502	Q16143	SYUB_HUMAN	beta-synuclein	25	1.|4 X 11 AA tandem repeats of [EGS]-K-T-K- [EQ]-[GQ]-V-X(4).						calcium ion binding|phospholipase inhibitor activity			ovary(1)	1	all_cancers(89;0.00222)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.00498)|all_neural(177;0.0212)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)															---	---	---	---
FAM193B	54540	broad.mit.edu	37	5	176951928	176951928	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:176951928T>C	uc003mhs.3	-	8	3044	c.1455A>G	c.(1453-1455)TCA>TCG	p.S485S	FAM193B_uc003mhr.2_Silent_p.S22S|FAM193B_uc003mht.2_Silent_p.S144S|FAM193B_uc003mhu.2_Silent_p.S197S|FAM193B_uc003mhv.2_Silent_p.S144S|FAM193B_uc003mhw.2_RNA	NM_019057	NP_061930	E9PET5	E9PET5_HUMAN	hypothetical protein LOC54540	518											0																		---	---	---	---
FLT4	2324	broad.mit.edu	37	5	180047183	180047183	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:180047183C>T	uc003mma.3	-	17	2611	c.2532G>A	c.(2530-2532)CGG>CGA	p.R844R	FLT4_uc003mlz.3_Silent_p.R844R|FLT4_uc003mmb.1_Silent_p.R377R	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	844	Cytoplasmic (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)									Congenital_Hereditary_Lymphedema				---	---	---	---
BTNL3	10917	broad.mit.edu	37	5	180432460	180432460	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:180432460T>A	uc003mmr.2	+	8	1117	c.989T>A	c.(988-990)GTG>GAG	p.V330E	BTNL3_uc010jlp.2_Missense_Mutation_p.V115E	NM_197975	NP_932079	Q6UXE8	BTNL3_HUMAN	butyrophilin-like 3 precursor	330	B30.2/SPRY.|Cytoplasmic (Potential).				lipid metabolic process	integral to membrane					0	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.00336)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)|all_lung(500;0.248)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000272)															---	---	---	---
IRF4	3662	broad.mit.edu	37	6	401701	401701	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:401701G>A	uc003msz.3	+	7	1136	c.1023G>A	c.(1021-1023)GCG>GCA	p.A341A	IRF4_uc010jne.1_Silent_p.A341A|IRF4_uc003mta.3_RNA|IRF4_uc003mtb.3_Silent_p.A340A|IRF4_uc003mtc.1_Silent_p.A171A	NM_002460	NP_002451	Q15306	IRF4_HUMAN	interferon regulatory factor 4	341					interferon-gamma-mediated signaling pathway|positive regulation of interleukin-10 biosynthetic process|positive regulation of interleukin-13 biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of transcription, DNA-dependent|regulation of T-helper cell differentiation|T cell activation|type I interferon-mediated signaling pathway	cytoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(1)	1		Breast(5;0.0155)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.03)|BRCA - Breast invasive adenocarcinoma(62;0.0702)				T	IGH@	MM 								---	---	---	---
BMP6	654	broad.mit.edu	37	6	7879334	7879334	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:7879334C>T	uc003mxu.3	+	5	1410	c.1232C>T	c.(1231-1233)GCC>GTC	p.A411V		NM_001718	NP_001709	P22004	BMP6_HUMAN	bone morphogenetic protein 6 preproprotein	411					BMP signaling pathway|cartilage development|growth|immune response|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	BMP receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity			large_intestine(2)|ovary(1)	3	Ovarian(93;0.0721)																	---	---	---	---
TXNDC5	81567	broad.mit.edu	37	6	7883385	7883385	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:7883385C>T	uc003mxv.2	-	10	1323	c.1291G>A	c.(1291-1293)GAA>AAA	p.E431K	TXNDC5_uc003mxw.2_Missense_Mutation_p.E388K|TXNDC5_uc010jnz.2_Missense_Mutation_p.E323K	NM_030810	NP_110437	Q8NBS9	TXND5_HUMAN	thioredoxin domain containing 5 isoform 1	431	Prevents secretion from ER (Potential).				anti-apoptosis|cell redox homeostasis|cellular membrane organization|glycerol ether metabolic process|post-Golgi vesicle-mediated transport	endoplasmic reticulum lumen|lysosomal lumen	electron carrier activity|isomerase activity|protein disulfide oxidoreductase activity				0	Ovarian(93;0.0398)																	---	---	---	---
EEF1E1	9521	broad.mit.edu	37	6	8097536	8097536	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:8097536C>T	uc003mxz.2	-	2	326	c.252G>A	c.(250-252)GGG>GGA	p.G84G	EEF1E1_uc011dic.1_Silent_p.G84G	NM_004280	NP_004271	O43324	MCA3_HUMAN	eukaryotic translation elongation factor 1	84	GST C-terminal.				negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of DNA damage response, signal transduction by p53 class mediator|tRNA aminoacylation for protein translation	cytosol|nucleus					0	Ovarian(93;0.0398)																	---	---	---	---
MAK	4117	broad.mit.edu	37	6	10830846	10830846	+	Silent	SNP	G	A	A	rs138352622		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:10830846G>A	uc003mzl.2	-	1	265	c.36C>T	c.(34-36)GAC>GAT	p.D12D	SYCP2L_uc011dim.1_Intron|TMEM14B_uc010jos.1_Intron|MAK_uc010jot.2_RNA|MAK_uc010jou.2_RNA|MAK_uc003mzm.2_Silent_p.D12D|MAK_uc010jov.1_RNA	NM_005906	NP_005897	P20794	MAK_HUMAN	male germ cell-associated kinase	12	ATP (By similarity).|Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|cyclin-dependent protein kinase activity			breast(2)|skin(1)	3	Breast(50;0.107)|Ovarian(93;0.107)	all_hematologic(90;0.117)																---	---	---	---
GFOD1	54438	broad.mit.edu	37	6	13365208	13365208	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:13365208G>A	uc003nat.1	-	2	1605	c.940C>T	c.(940-942)CGC>TGC	p.R314C	GFOD1_uc003nas.1_Missense_Mutation_p.R211C	NM_018988	NP_061861	Q9NXC2	GFOD1_HUMAN	glucose-fructose oxidoreductase domain	314						extracellular region	binding|oxidoreductase activity			ovary(2)	2	Breast(50;0.0296)|Ovarian(93;0.0454)	all_hematologic(90;0.135)	Epithelial(50;0.0348)|BRCA - Breast invasive adenocarcinoma(129;0.1)|all cancers(50;0.108)															---	---	---	---
RANBP9	10048	broad.mit.edu	37	6	13639807	13639807	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:13639807C>T	uc003nbb.2	-	9	1572	c.1513G>A	c.(1513-1515)GCA>ACA	p.A505T	RANBP9_uc003nba.2_Missense_Mutation_p.A164T	NM_005493	NP_005484	Q96S59	RANB9_HUMAN	RAN binding protein 9	505					axon guidance|microtubule nucleation|protein complex assembly	cytosol|microtubule associated complex|nucleus	Ran GTPase binding			lung(1)|skin(1)	2	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.223)															---	---	---	---
NHLRC1	378884	broad.mit.edu	37	6	18122487	18122487	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:18122487G>A	uc003ncl.1	-	1	365	c.351C>T	c.(349-351)CAC>CAT	p.H117H		NM_198586	NP_940988	Q6VVB1	NHLC1_HUMAN	NHL repeat containing 1	117	NHL 1.				proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	endoplasmic reticulum|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0	Ovarian(93;0.016)|Breast(50;0.0245)	all_hematologic(90;0.165)	all cancers(50;0.0451)|Epithelial(50;0.0493)															---	---	---	---
MBOAT1	154141	broad.mit.edu	37	6	20126880	20126880	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:20126880A>C	uc003ncx.1	-	7	787	c.582T>G	c.(580-582)AGT>AGG	p.S194R	MBOAT1_uc011dji.1_Missense_Mutation_p.S45R	NM_001080480	NP_001073949	Q6ZNC8	MBOA1_HUMAN	membrane bound O-acyltransferase domain	194	Helical; (Potential).				phospholipid biosynthetic process	integral to membrane	acyltransferase activity				0	all_cancers(95;0.244)|Breast(50;0.0379)|Ovarian(93;0.0473)|all_epithelial(95;0.109)		OV - Ovarian serous cystadenocarcinoma(7;0.00392)|all cancers(50;0.0117)|Epithelial(50;0.0454)													OREG0017224	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
GPLD1	2822	broad.mit.edu	37	6	24436892	24436892	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:24436892C>T	uc003ned.1	-	22	2381	c.2270G>A	c.(2269-2271)CGA>CAA	p.R757Q		NM_001503	NP_001494	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific	757	FG-GAP 6.					extracellular region	glycosylphosphatidylinositol phospholipase D activity			ovary(2)|kidney(1)	3																		---	---	---	---
GPLD1	2822	broad.mit.edu	37	6	24437377	24437377	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:24437377C>T	uc003ned.1	-	21	2272	c.2161G>A	c.(2161-2163)GTT>ATT	p.V721I		NM_001503	NP_001494	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific	721	FG-GAP 6.					extracellular region	glycosylphosphatidylinositol phospholipase D activity			ovary(2)|kidney(1)	3																		---	---	---	---
HIST1H1E	3008	broad.mit.edu	37	6	26156607	26156607	+	5'UTR	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:26156607C>T	uc003ngq.2	+	1					HIST1H2BD_uc003ngr.2_5'Flank|HIST1H2BD_uc003ngs.2_5'Flank	NM_005321	NP_005312			histone cluster 1, H1e						nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			large_intestine(1)|ovary(1)	2																		---	---	---	---
ABT1	29777	broad.mit.edu	37	6	26598635	26598635	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:26598635G>A	uc003nii.2	+	3	612	c.581G>A	c.(580-582)CGC>CAC	p.R194H		NM_013375	NP_037507	Q9ULW3	ABT1_HUMAN	activator of basal transcription 1	194					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleolus	DNA binding|nucleotide binding|protein binding|RNA binding|transcription coactivator activity			ovary(1)	1																		---	---	---	---
HIST1H4K	8362	broad.mit.edu	37	6	27799049	27799049	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:27799049T>C	uc003njr.2	-	1	257	c.257A>G	c.(256-258)GAT>GGT	p.D86G		NM_003541	NP_003532	P62805	H4_HUMAN	histone cluster 1, H4k	86					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding				0																		---	---	---	---
OR10C1	442194	broad.mit.edu	37	6	29408484	29408484	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:29408484C>T	uc011dlp.1	+	1	692	c.692C>T	c.(691-693)GCG>GTG	p.A231V	OR11A1_uc010jrh.1_Intron	NM_013941	NP_039229	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C,	231	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0																		---	---	---	---
HLA-L	3139	broad.mit.edu	37	6	30229066	30229066	+	Silent	SNP	G	A	A	rs138456149	byFrequency;by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:30229066G>A	uc003npv.2	+	4	591	c.141G>A	c.(139-141)GCG>GCA	p.A47A		NR_027822				SubName: Full=MHC class I antigen; Flags: Fragment;												0																		---	---	---	---
PPP1R10	5514	broad.mit.edu	37	6	30571998	30571998	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:30571998G>A	uc003nqn.1	-	14	1847	c.1295C>T	c.(1294-1296)GCG>GTG	p.A432V	PPP1R10_uc010jsc.1_Missense_Mutation_p.A86V	NM_002714	NP_002705	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	432	Essential for PPP1CA inhibition (By similarity).|Interaction with WDR82 (By similarity).				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			ovary(2)|lung(1)|kidney(1)	4																		---	---	---	---
MUC21	394263	broad.mit.edu	37	6	30954121	30954121	+	Missense_Mutation	SNP	G	A	A	rs137862032		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:30954121G>A	uc003nsh.2	+	2	420	c.169G>A	c.(169-171)GTC>ATC	p.V57I	MUC21_uc003nsi.1_RNA	NM_001010909	NP_001010909	Q5SSG8	MUC21_HUMAN	mucin 21 precursor	57	Ser-rich.|2.|28 X 15 AA approximate tandem repeats.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(1)|skin(1)	2																		---	---	---	---
HLA-B	3106	broad.mit.edu	37	6	31323280	31323280	+	Missense_Mutation	SNP	T	A	A	rs74353323		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:31323280T>A	uc003nth.2	-	4	763	c.709A>T	c.(709-711)ATC>TTC	p.I237F	HLA-C_uc003ntb.2_RNA|HLA-C_uc003ntc.1_5'Flank|HLA-B_uc010jsm.1_RNA|HLA-B_uc011dnk.1_RNA|HLA-B_uc003ntf.2_Intron|HLA-B_uc003ntg.1_Missense_Mutation_p.I116F|HLA-B_uc003nti.1_RNA|HLA-B_uc010jsn.1_RNA	NM_005514	NP_005505	P01889	1B07_HUMAN	major histocompatibility complex, class I, B	237	Alpha-3.|Ig-like C1-type.|Extracellular (Potential).				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity				0														Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of				---	---	---	---
C6orf25	80739	broad.mit.edu	37	6	31691442	31691442	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:31691442C>T	uc011doc.1	+	2	88	c.88C>T	c.(88-90)CGG>TGG	p.R30W	LY6G6C_uc003nwh.2_5'Flank|LY6G6C_uc010jtd.2_5'Flank|C6orf25_uc003nwk.2_Missense_Mutation_p.R30W|C6orf25_uc011dod.1_Missense_Mutation_p.R30W|C6orf25_uc011doe.1_Missense_Mutation_p.R30W|C6orf25_uc003nwo.2_Missense_Mutation_p.R30W|C6orf25_uc003nwn.2_Missense_Mutation_p.R30W	NM_138272	NP_612116	O95866	G6B_HUMAN	G6B protein isoform G6b-B precursor	30	Extracellular (Potential).					endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	heparin binding|receptor activity				0																		---	---	---	---
VARS	7407	broad.mit.edu	37	6	31749307	31749307	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:31749307C>T	uc003nxe.2	-	21	2918	c.2495G>A	c.(2494-2496)CGG>CAG	p.R832Q	VARS_uc003nxf.1_5'Flank	NM_006295	NP_006286	P26640	SYVC_HUMAN	valyl-tRNA synthetase	832					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3					L-Valine(DB00161)													---	---	---	---
HSPA1L	3305	broad.mit.edu	37	6	31779305	31779305	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:31779305G>A	uc003nxh.2	-	2	628	c.445C>T	c.(445-447)CCA>TCA	p.P149S	HSPA1L_uc010jte.2_Missense_Mutation_p.P149S	NM_005527	NP_005518	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	149					response to unfolded protein		ATP binding			ovary(3)|pleura(1)|kidney(1)|skin(1)	6																		---	---	---	---
HSPA1A	3303	broad.mit.edu	37	6	31783569	31783569	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:31783569C>T	uc003nxj.2	+	1	279	c.36C>T	c.(34-36)GGC>GGT	p.G12G	HSPA1L_uc003nxh.2_5'Flank|HSPA1L_uc010jte.2_5'Flank|HSPA1A_uc011doj.1_Silent_p.G12G|HSPA1A_uc003nxi.1_Silent_p.G12G|uc011dok.1_RNA	NM_005345	NP_005336	P08107	HSP71_HUMAN	heat shock 70kDa protein 1A	12					anti-apoptosis|mRNA catabolic process|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of inclusion body assembly|protein refolding|response to unfolded protein	cytosol|endoplasmic reticulum|inclusion body|mitochondrion|nuclear speck|perinuclear region of cytoplasm|ribonucleoprotein complex	ATP binding|protein binding involved in protein folding|protein N-terminus binding|receptor activity|ubiquitin protein ligase binding|unfolded protein binding			ovary(1)	1																		---	---	---	---
ZBTB12	221527	broad.mit.edu	37	6	31868445	31868445	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:31868445A>G	uc003nyd.1	-	2	814	c.638T>C	c.(637-639)GTG>GCG	p.V213A	EHMT2_uc003nxz.1_5'Flank|EHMT2_uc003nya.1_5'Flank|EHMT2_uc003nyb.1_5'Flank|C2_uc003nyc.2_Intron|C2_uc011doo.1_Intron|C2_uc011dop.1_5'Flank	NM_181842	NP_862825	Q9Y330	ZBT12_HUMAN	zinc finger and BTB domain containing 12	213					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
NOTCH4	4855	broad.mit.edu	37	6	32166717	32166717	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:32166717G>A	uc003obb.2	-	24	4660	c.4521C>T	c.(4519-4521)GAC>GAT	p.D1507D	NOTCH4_uc011dpt.1_5'Flank|NOTCH4_uc003oba.2_Silent_p.D170D|NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA|NOTCH4_uc011dpw.1_5'Flank	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1507	Cytoplasmic (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22																		---	---	---	---
IP6K3	117283	broad.mit.edu	37	6	33694543	33694543	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:33694543C>T	uc010jvf.2	-	5	1090	c.554G>A	c.(553-555)CGC>CAC	p.R185H	IP6K3_uc003ofb.2_Missense_Mutation_p.R185H	NM_001142883	NP_001136355	Q96PC2	IP6K3_HUMAN	inositol hexakisphosphate kinase 3	185					inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|protein phosphorylation	cytoplasm	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol hexakisphosphate 6-kinase activity|inositol trisphosphate 3-kinase activity				0																		---	---	---	---
MOCS1	4337	broad.mit.edu	37	6	39895325	39895325	+	5'UTR	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:39895325C>T	uc003opb.2	-	1					MOCS1_uc003opa.2_5'UTR|MOCS1_uc003opc.2_5'UTR|MOCS1_uc003opd.2_Intron|MOCS1_uc003ope.2_Intron	NM_005942	NP_005933			molybdenum cofactor synthesis-step 1 protein						Mo-molybdopterin cofactor biosynthetic process|Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol|molybdopterin synthase complex|nucleus	4 iron, 4 sulfur cluster binding|4 iron, 4 sulfur cluster binding|catalytic activity|GTP binding|metal ion binding			ovary(1)|liver(1)|central_nervous_system(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)																	---	---	---	---
TREM2	54209	broad.mit.edu	37	6	41129134	41129134	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:41129134G>A	uc003opy.2	-	2	360	c.258C>T	c.(256-258)GAC>GAT	p.D86D	TREM2_uc003opz.2_Silent_p.D116D|TREM2_uc010jxl.1_Silent_p.D116D	NM_018965	NP_061838	Q9NZC2	TREM2_HUMAN	triggering receptor expressed on myeloid cells 2	86	Ig-like V-type.|Extracellular (Potential).				axon guidance|humoral immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			ovary(1)	1	Ovarian(28;0.0418)|Colorectal(47;0.196)																	---	---	---	---
TFEB	7942	broad.mit.edu	37	6	41657522	41657522	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:41657522G>A	uc003oqs.1	-	5	798	c.496C>T	c.(496-498)CGT>TGT	p.R166C	TFEB_uc003oqt.1_Missense_Mutation_p.R166C|TFEB_uc003oqu.1_Missense_Mutation_p.R180C|TFEB_uc003oqv.1_Missense_Mutation_p.R166C|TFEB_uc010jxo.1_Missense_Mutation_p.R166C|TFEB_uc003oqr.1_Missense_Mutation_p.R81C	NM_007162	NP_009093	P19484	TFEB_HUMAN	transcription factor EB	166					embryonic placenta development|humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(1)	1	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;7.61e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)					T	ALPHA	renal (childhood epithelioid)								---	---	---	---
MRPL14	64928	broad.mit.edu	37	6	44081904	44081904	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:44081904T>C	uc003owp.2	-	3	243	c.114A>G	c.(112-114)GTA>GTG	p.V38V		NM_032111	NP_115487	Q6P1L8	RM14_HUMAN	mitochondrial ribosomal protein L14 precursor	38					translation	mitochondrion|ribosome	structural constituent of ribosome			ovary(1)	1	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0181)															---	---	---	---
CAPN11	11131	broad.mit.edu	37	6	44144338	44144338	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:44144338T>C	uc003owt.1	+	10	1060	c.1022T>C	c.(1021-1023)GTG>GCG	p.V341A	CAPN11_uc011dvn.1_5'UTR	NM_007058	NP_008989	Q9UMQ6	CAN11_HUMAN	calpain 11	341	Calpain catalytic.				proteolysis	acrosomal vesicle	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			ovary(1)|breast(1)	2	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)															---	---	---	---
TCTE1	202500	broad.mit.edu	37	6	44249924	44249924	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:44249924C>T	uc003oxi.2	-	4	1375	c.1219G>A	c.(1219-1221)GCC>ACC	p.A407T	SPATS1_uc003oxg.2_Intron|TMEM151B_uc003oxf.2_Intron	NM_182539	NP_872345	Q5JU00	TCTE1_HUMAN	t-complex-associated testis expressed 1	407	LRR 4.									ovary(2)|skin(2)	4	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)															---	---	---	---
TDRD6	221400	broad.mit.edu	37	6	46660256	46660256	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:46660256A>C	uc003oyj.2	+	1	4391	c.4391A>C	c.(4390-4392)GAT>GCT	p.D1464A	TDRD6_uc010jze.2_Missense_Mutation_p.D1458A	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1464					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)															---	---	---	---
GPR110	266977	broad.mit.edu	37	6	46968003	46968003	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:46968003A>G	uc003oyt.2	-	15	2888	c.2689T>C	c.(2689-2691)TCC>CCC	p.S897P	GPR110_uc011dwl.1_Missense_Mutation_p.S585P	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	897	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3																		---	---	---	---
PGK2	5232	broad.mit.edu	37	6	49753713	49753713	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:49753713G>A	uc003ozu.2	-	1	1295	c.1188C>T	c.(1186-1188)GGC>GGT	p.G396G		NM_138733	NP_620061	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	396				G -> R (in Ref. 1; CAA28872).	glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			ovary(1)	1	Lung NSC(77;0.0402)																	---	---	---	---
C6orf142	90523	broad.mit.edu	37	6	53989529	53989529	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:53989529C>T	uc003pcg.3	+	3	591	c.478C>T	c.(478-480)CGG>TGG	p.R160W	C6orf142_uc003pcf.2_Missense_Mutation_p.R160W|C6orf142_uc003pch.3_Missense_Mutation_p.R98W|C6orf142_uc011dwz.1_Missense_Mutation_p.R119W|C6orf142_uc011dxa.1_Missense_Mutation_p.R171W	NM_138569	NP_612636	Q5VWP3	MLIP_HUMAN	hypothetical protein LOC90523	160						nuclear envelope|PML body	protein binding				0	Lung NSC(77;0.0317)																	---	---	---	---
DST	667	broad.mit.edu	37	6	56469171	56469171	+	Intron	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:56469171G>T	uc003pdf.2	-						DST_uc003pcz.3_Intron|DST_uc011dxj.1_Intron|DST_uc011dxk.1_Intron|DST_uc003pcy.3_Intron|DST_uc003pdb.2_Missense_Mutation_p.P2882T	NM_001144769	NP_001138241			dystonin isoform 2						cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)															---	---	---	---
DST	667	broad.mit.edu	37	6	56485185	56485185	+	Intron	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:56485185C>A	uc003pdf.2	-						DST_uc003pcz.3_Intron|DST_uc011dxj.1_Intron|DST_uc011dxk.1_Intron|DST_uc003pcy.3_Intron|DST_uc003pdb.2_Intron|DST_uc003pdc.3_Missense_Mutation_p.R1216L	NM_001144769	NP_001138241			dystonin isoform 2						cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)															---	---	---	---
ZNF451	26036	broad.mit.edu	37	6	57013493	57013493	+	Splice_Site	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:57013493T>C	uc003pdm.1	+	10	2832	c.2608_splice	c.e10+2	p.E870_splice	ZNF451_uc003pdl.2_Splice_Site_p.E870_splice|ZNF451_uc003pdn.1_Splice_Site_p.G870_splice|uc003pdq.1_Intron|ZNF451_uc003pdk.1_Splice_Site_p.E870_splice	NM_001031623	NP_001026794			zinc finger protein 451 isoform 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)															---	---	---	---
CD109	135228	broad.mit.edu	37	6	74472143	74472143	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:74472143G>A	uc003php.2	+	8	1220	c.795G>A	c.(793-795)ACG>ACA	p.T265T	CD109_uc010kaz.2_Silent_p.T265T|CD109_uc003phq.2_Silent_p.T265T|CD109_uc010kba.2_Silent_p.T188T	NM_133493	NP_598000	Q6YHK3	CD109_HUMAN	CD109 antigen isoform 1 precursor	265						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			large_intestine(2)|ovary(2)	4																		---	---	---	---
PM20D2	135293	broad.mit.edu	37	6	89871856	89871856	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:89871856G>A	uc003pmz.2	+	7	1280	c.1185G>A	c.(1183-1185)CTG>CTA	p.L395L		NM_001010853	NP_001010853	Q8IYS1	P20D2_HUMAN	aminoacylase 1-like 2	395							hydrolase activity				0		all_cancers(76;9.47e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00813)														---	---	---	---
MDN1	23195	broad.mit.edu	37	6	90354841	90354841	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:90354841G>A	uc003pnn.1	-	101	16611	c.16495C>T	c.(16495-16497)CGA>TGA	p.R5499*		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	5499	VWFA.				protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)														---	---	---	---
EPHA7	2045	broad.mit.edu	37	6	93956715	93956715	+	Intron	SNP	A	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:93956715A>C	uc003poe.2	-						EPHA7_uc003pof.2_Intron|EPHA7_uc011eac.1_Intron	NM_004440	NP_004431			ephrin receptor EphA7 precursor							integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)														---	---	---	---
C6orf167	253714	broad.mit.edu	37	6	97711302	97711302	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:97711302A>G	uc003ppb.2	-	9	1117	c.851T>C	c.(850-852)ATG>ACG	p.M284T	C6orf167_uc011eaf.1_Missense_Mutation_p.M284T|C6orf167_uc010kcn.1_Missense_Mutation_p.M58T|C6orf167_uc010kco.1_Intron|C6orf167_uc003ppc.2_Missense_Mutation_p.M284T	NM_198468	NP_940870	Q6ZRQ5	MMS22_HUMAN	hypothetical protein LOC253714	284					double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding				0		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.148)|Colorectal(196;0.198)		BRCA - Breast invasive adenocarcinoma(108;0.0457)														---	---	---	---
POU3F2	5454	broad.mit.edu	37	6	99282812	99282812	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:99282812C>T	uc003ppe.2	+	1	233	c.63C>T	c.(61-63)GCC>GCT	p.A21A		NM_005604	NP_005595	P20265	PO3F2_HUMAN	POU domain, class 3, transcription factor 2	21					positive regulation of cell proliferation		identical protein binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(76;1.56e-06)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00893)|Colorectal(196;0.069)|Lung NSC(302;0.197)		BRCA - Breast invasive adenocarcinoma(108;0.0355)														---	---	---	---
C6orf182	285753	broad.mit.edu	37	6	109481930	109481930	+	Intron	SNP	T	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:109481930T>G	uc010kdk.2	+						C6orf182_uc003psx.3_Missense_Mutation_p.L391R|C6orf182_uc010kdl.2_Intron|C6orf182_uc003psy.3_Intron	NM_001083535	NP_001077004			hypothetical protein LOC285753							microtubule|microtubule organizing center					0		all_cancers(87;4.45e-07)|Acute lymphoblastic leukemia(125;2.15e-10)|all_hematologic(75;3.25e-08)|all_epithelial(87;0.000254)|Colorectal(196;0.0293)|all_lung(197;0.11)		BRCA - Breast invasive adenocarcinoma(108;0.00123)|Epithelial(106;0.0022)|all cancers(137;0.00405)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)														---	---	---	---
REV3L	5980	broad.mit.edu	37	6	111695978	111695978	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:111695978G>A	uc003puy.3	-	13	3903	c.3580C>T	c.(3580-3582)CGA>TGA	p.R1194*	REV3L_uc003pux.3_Nonsense_Mutation_p.R1116*|REV3L_uc003puz.3_Nonsense_Mutation_p.R1116*	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	1194					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)									DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					---	---	---	---
GOPC	57120	broad.mit.edu	37	6	117894769	117894769	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:117894769C>T	uc003pxu.2	-	5	907	c.677G>A	c.(676-678)CGA>CAA	p.R226Q	GOPC_uc003pxq.1_5'UTR|GOPC_uc003pxv.2_Missense_Mutation_p.R218Q	NM_020399	NP_065132	Q9HD26	GOPC_HUMAN	golgi associated PDZ and coiled-coil motif	226					apical protein localization|cytoplasmic sequestering of CFTR protein|ER to Golgi vesicle-mediated transport|Golgi to plasma membrane transport|protein homooligomerization|protein transport	cell junction|dendrite|Golgi membrane|postsynaptic density|postsynaptic membrane|trans-Golgi network transport vesicle	cystic fibrosis transmembrane conductance regulator binding			ovary(1)	1		all_cancers(87;0.00844)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0363)|OV - Ovarian serous cystadenocarcinoma(136;0.0821)|all cancers(137;0.0976)				O	ROS1	glioblastoma								---	---	---	---
HDDC2	51020	broad.mit.edu	37	6	125619868	125619868	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:125619868G>A	uc003qaa.1	-	3	505	c.301C>T	c.(301-303)CGA>TGA	p.R101*	HDDC2_uc003qab.1_Intron	NM_016063	NP_057147	Q7Z4H3	HDDC2_HUMAN	HD domain containing 2	101	HD.						metal ion binding|phosphoric diester hydrolase activity				0			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0186)														---	---	---	---
LAMA2	3908	broad.mit.edu	37	6	129766950	129766950	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:129766950G>A	uc003qbn.2	+	44	6518	c.6413G>A	c.(6412-6414)CGG>CAG	p.R2138Q	LAMA2_uc003qbo.2_Missense_Mutation_p.R2138Q	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	2138	Domain II and I.|Potential.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)														---	---	---	---
C6orf192	116843	broad.mit.edu	37	6	133108570	133108570	+	Intron	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:133108570T>C	uc003qdw.1	-						C6orf192_uc011eco.1_Intron	NM_052831	NP_439896			hypothetical protein LOC116843						transmembrane transport	integral to membrane				ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(155;0.00303)|GBM - Glioblastoma multiforme(226;0.0265)														---	---	---	---
MAP3K5	4217	broad.mit.edu	37	6	136926362	136926362	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:136926362T>C	uc003qhc.2	-	19	3025	c.2664A>G	c.(2662-2664)CAA>CAG	p.Q888Q	MAP3K5_uc011edj.1_Silent_p.Q135Q|MAP3K5_uc011edk.1_Silent_p.Q733Q	NM_005923	NP_005914	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase	888	Protein kinase.				activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			ovary(2)|skin(2)|lung(1)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)														---	---	---	---
GPR126	57211	broad.mit.edu	37	6	142721737	142721737	+	Intron	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:142721737A>G	uc010khc.2	+						GPR126_uc010khd.2_Intron|GPR126_uc010khe.2_Intron|GPR126_uc010khf.2_Intron	NM_020455	NP_065188			G protein-coupled receptor 126 alpha 1						neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)														---	---	---	---
UTRN	7402	broad.mit.edu	37	6	144872230	144872230	+	Intron	SNP	A	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:144872230A>T	uc003qkt.2	+							NM_007124	NP_009055			utrophin						muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)														---	---	---	---
AKAP12	9590	broad.mit.edu	37	6	151672225	151672225	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:151672225C>T	uc011eep.1	+	4	2939	c.2699C>T	c.(2698-2700)ACG>ATG	p.T900M	AKAP12_uc003qoe.2_Missense_Mutation_p.T900M|AKAP12_uc003qof.2_Missense_Mutation_p.T802M|AKAP12_uc010kim.2_Intron|AKAP12_uc003qog.2_Missense_Mutation_p.T795M	NM_005100	NP_005091	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12 isoform 1	900					G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	8		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)														---	---	---	---
C6orf211	79624	broad.mit.edu	37	6	151790214	151790214	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:151790214A>G	uc003qok.1	+	5	1554	c.1295A>G	c.(1294-1296)TAT>TGT	p.Y432C	C6orf211_uc011ees.1_Missense_Mutation_p.Y313C	NM_024573	NP_078849	Q9H993	CF211_HUMAN	hypothetical protein LOC79624	432							protein binding				0			BRCA - Breast invasive adenocarcinoma(37;0.183)	OV - Ovarian serous cystadenocarcinoma(155;5.27e-11)														---	---	---	---
SYNE1	23345	broad.mit.edu	37	6	152540160	152540160	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:152540160C>T	uc010kiw.2	-	120	22624	c.22022G>A	c.(22021-22023)TGC>TAC	p.C7341Y	SYNE1_uc010kiv.2_Missense_Mutation_p.C1865Y|SYNE1_uc003qos.3_Missense_Mutation_p.C1865Y|SYNE1_uc003qot.3_Missense_Mutation_p.C7270Y|SYNE1_uc003qou.3_Missense_Mutation_p.C7341Y|SYNE1_uc003qor.3_Missense_Mutation_p.C241Y	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7341	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)											HNSCC(10;0.0054)			---	---	---	---
SYNE1	23345	broad.mit.edu	37	6	152623111	152623111	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:152623111C>T	uc010kiw.2	-	92	18036	c.17434G>A	c.(17434-17436)GCC>ACC	p.A5812T	SYNE1_uc010kiv.2_Missense_Mutation_p.A336T|SYNE1_uc003qos.3_Missense_Mutation_p.A336T|SYNE1_uc003qot.3_Missense_Mutation_p.A5741T|SYNE1_uc003qou.3_Missense_Mutation_p.A5812T|SYNE1_uc010kiy.1_Missense_Mutation_p.A34T	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5812	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)											HNSCC(10;0.0054)			---	---	---	---
RBM16	22828	broad.mit.edu	37	6	155114112	155114112	+	Splice_Site	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:155114112T>C	uc003qqa.2	+	6	707	c.475_splice	c.e6+2	p.G159_splice	RBM16_uc011efj.1_Splice_Site_p.G225_splice|RBM16_uc011efk.1_Splice_Site_p.G204_splice|RBM16_uc003qpz.2_Splice_Site_p.G159_splice|RBM16_uc010kji.2_Splice_Site_p.G180_splice	NM_014892	NP_055707			RNA-binding motif protein 16						mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding				0		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;2.33e-15)|BRCA - Breast invasive adenocarcinoma(81;0.00524)														---	---	---	---
TULP4	56995	broad.mit.edu	37	6	158925205	158925205	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:158925205C>T	uc003qrf.2	+	13	5867	c.4510C>T	c.(4510-4512)CGG>TGG	p.R1504W	TULP4_uc003qrg.2_Intron	NM_020245	NP_064630	Q9NRJ4	TULP4_HUMAN	tubby like protein 4 isoform 1	1504	TUB.				intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)														---	---	---	---
RPS6KA2	6196	broad.mit.edu	37	6	166844007	166844007	+	Silent	SNP	C	T	T	rs140163975		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:166844007C>T	uc003qvb.1	-	16	1734	c.1515G>A	c.(1513-1515)TCG>TCA	p.S505S	RPS6KA2_uc011ego.1_Silent_p.S416S|RPS6KA2_uc010kkl.1_Silent_p.S416S|RPS6KA2_uc003qvc.1_Silent_p.S513S|RPS6KA2_uc003qvd.1_Silent_p.S530S	NM_021135	NP_066958	Q15349	KS6A2_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	505	Protein kinase 2.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|skin(2)|large_intestine(1)|central_nervous_system(1)	8		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)														---	---	---	---
WDR27	253769	broad.mit.edu	37	6	170059556	170059556	+	Silent	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:170059556C>A	uc003qwx.2	-	11	1708	c.1188G>T	c.(1186-1188)GCG>GCT	p.A396A	WDR27_uc003qwv.1_RNA|WDR27_uc010kkw.1_Silent_p.A396A|WDR27_uc003qwy.2_Silent_p.A269A|WDR27_uc003qwz.1_Silent_p.A129A			A2RRH5	WDR27_HUMAN	RecName: Full=WD repeat-containing protein 27;	366										pancreas(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.216)		OV - Ovarian serous cystadenocarcinoma(33;6.48e-20)|BRCA - Breast invasive adenocarcinoma(81;3.56e-07)|GBM - Glioblastoma multiforme(31;0.00168)														---	---	---	---
INTS1	26173	broad.mit.edu	37	7	1538951	1538951	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:1538951G>A	uc003skn.2	-	7	991	c.890C>T	c.(889-891)ACG>ATG	p.T297M	INTS1_uc003skq.2_Missense_Mutation_p.T297M	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	297					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)														---	---	---	---
CHST12	55501	broad.mit.edu	37	7	2472864	2472864	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:2472864G>A	uc003smc.2	+	2	725	c.590G>A	c.(589-591)CGC>CAC	p.R197H	CHST12_uc003smd.2_Missense_Mutation_p.R197H	NM_018641	NP_061111	Q9NRB3	CHSTC_HUMAN	carbohydrate sulfotransferase 12	197	Lumenal (Potential).				dermatan sulfate biosynthetic process	integral to Golgi membrane	3'-phosphoadenosine 5'-phosphosulfate binding|chondroitin 4-sulfotransferase activity|protein binding			kidney(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0847)|OV - Ovarian serous cystadenocarcinoma(56;2.25e-13)														---	---	---	---
IQCE	23288	broad.mit.edu	37	7	2618149	2618149	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:2618149G>A	uc003smo.3	+	8	803	c.619G>A	c.(619-621)GAT>AAT	p.D207N	IQCE_uc010ksm.1_Missense_Mutation_p.D207N|IQCE_uc003sml.1_Missense_Mutation_p.D207N|IQCE_uc011jvy.1_Missense_Mutation_p.D191N|IQCE_uc011jvz.1_Missense_Mutation_p.D142N|IQCE_uc003smk.3_Missense_Mutation_p.D191N|IQCE_uc003smn.3_Missense_Mutation_p.D142N	NM_152558	NP_689771	Q6IPM2	IQCE_HUMAN	IQ motif containing E isoform 1	207	Potential.										0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;1.23e-13)														---	---	---	---
SDK1	221935	broad.mit.edu	37	7	4198100	4198100	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:4198100A>G	uc003smx.2	+	31	4785	c.4646A>G	c.(4645-4647)TAC>TGC	p.Y1549C	SDK1_uc010kso.2_Missense_Mutation_p.Y825C|SDK1_uc003smy.2_Missense_Mutation_p.Y36C	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1549	Fibronectin type-III 9.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)														---	---	---	---
WIPI2	26100	broad.mit.edu	37	7	5267771	5267771	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:5267771C>T	uc003snv.2	+	11	1266	c.1050C>T	c.(1048-1050)GCC>GCT	p.A350A	WIPI2_uc003snw.2_Silent_p.A350A|WIPI2_uc003snx.2_Silent_p.A332A|WIPI2_uc003sny.2_Silent_p.A332A|WIPI2_uc010ksv.2_Silent_p.A206A|WIPI2_uc003soa.2_Silent_p.A291A|WIPI2_uc003sob.2_Silent_p.A93A	NM_015610	NP_056425	Q9Y4P8	WIPI2_HUMAN	WD repeat domain, phosphoinositide interacting 2	350	WD 3.				autophagic vacuole assembly	cytosol|PAS complex|pre-autophagosomal structure membrane	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding			ovary(2)	2		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0925)|OV - Ovarian serous cystadenocarcinoma(56;2.59e-14)														---	---	---	---
TNRC18	84629	broad.mit.edu	37	7	5347923	5347923	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:5347923C>T	uc003soi.3	-	30	9070	c.8721G>A	c.(8719-8721)TCG>TCA	p.S2907S		NM_001080495	NP_001073964	O15417	TNC18_HUMAN	trinucleotide repeat containing 18	2907	BAH.						DNA binding				0		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)														---	---	---	---
TNRC18	84629	broad.mit.edu	37	7	5399108	5399108	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:5399108G>A	uc003soi.3	-	15	5103	c.4754C>T	c.(4753-4755)GCC>GTC	p.A1585V	TNRC18_uc003soj.2_5'Flank	NM_001080495	NP_001073964	O15417	TNC18_HUMAN	trinucleotide repeat containing 18	1585							DNA binding				0		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)														---	---	---	---
THSD7A	221981	broad.mit.edu	37	7	11630185	11630185	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:11630185G>A	uc003ssf.3	-	4	1607	c.1355C>T	c.(1354-1356)ACG>ATG	p.T452M		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	452	Extracellular (Potential).|TSP type-1 4.					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)											HNSCC(18;0.044)			---	---	---	---
ETV1	2115	broad.mit.edu	37	7	13971290	13971290	+	Silent	SNP	G	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:13971290G>C	uc011jxq.1	-	9	1378	c.639C>G	c.(637-639)CGC>CGG	p.R213R	ETV1_uc011jxn.1_Silent_p.R173R|ETV1_uc011jxo.1_Silent_p.R110R|ETV1_uc011jxp.1_Silent_p.R155R|ETV1_uc003ssw.3_Silent_p.R213R|ETV1_uc003ssx.2_RNA|ETV1_uc011jxr.1_Silent_p.R195R|ETV1_uc011jxs.1_Silent_p.R195R|ETV1_uc010ktv.2_Silent_p.R82R	NM_004956	NP_004947	P50549	ETV1_HUMAN	ets variant gene 1 isoform a	213					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		TMPRSS2/ETV1(24)|EWSR1/ETV1(7)	prostate(24)|soft_tissue(4)|bone(3)|lung(2)|central_nervous_system(1)|ovary(1)	35								T	EWSR1|TMPRSS2|SLC45A3|C15orf21|HNRNPA2B1. ACSL3	Ewing sarcoma|prostate								---	---	---	---
HOXA7	3204	broad.mit.edu	37	7	27194723	27194723	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:27194723C>T	uc003sys.2	-	2	630	c.498G>A	c.(496-498)GCG>GCA	p.A166A	HOXA6_uc003syq.1_5'Flank|uc003syr.1_3'UTR	NM_006896	NP_008827	P31268	HXA7_HUMAN	homeobox A7	166	Homeobox.				angiogenesis|negative regulation of cell-matrix adhesion|negative regulation of keratinocyte differentiation|negative regulation of leukocyte migration|negative regulation of monocyte differentiation|negative regulation of transcription from RNA polymerase II promoter		sequence-specific DNA binding|transcription factor binding				0																		---	---	---	---
ZNRF2	223082	broad.mit.edu	37	7	30363271	30363271	+	Silent	SNP	T	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:30363271T>G	uc003tat.2	+	2	1534	c.483T>G	c.(481-483)CCT>CCG	p.P161P		NM_147128	NP_667339	Q8NHG8	ZNRF2_HUMAN	zinc finger/RING finger 2	161						cell junction|endosome membrane|lysosomal membrane|presynaptic membrane	ligase activity|zinc ion binding				0																		---	---	---	---
CRHR2	1395	broad.mit.edu	37	7	30721549	30721549	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:30721549C>T	uc003tbn.2	-	2	455	c.211G>A	c.(211-213)GTC>ATC	p.V71I	CRHR2_uc010kvw.1_Missense_Mutation_p.V71I|CRHR2_uc010kvx.1_Missense_Mutation_p.V71I|CRHR2_uc010kvy.1_5'UTR|CRHR2_uc003tbo.2_Missense_Mutation_p.V57I|CRHR2_uc003tbp.2_Missense_Mutation_p.V98I|CRHR2_uc010kvz.1_RNA|CRHR2_uc003tbq.1_RNA	NM_001883	NP_001874	Q13324	CRFR2_HUMAN	corticotropin releasing hormone receptor 2	71	Extracellular (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			lung(2)|ovary(1)|skin(1)	4																		---	---	---	---
KBTBD2	25948	broad.mit.edu	37	7	32909149	32909149	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:32909149C>T	uc003tdb.2	-	4	2339	c.1680G>A	c.(1678-1680)CGG>CGA	p.R560R	AVL9_uc011kai.1_Intron	NM_015483	NP_056298	Q8IY47	KBTB2_HUMAN	kelch repeat and BTB (POZ) domain containing 2	560	Kelch 5.										0			GBM - Glioblastoma multiforme(11;0.0499)															---	---	---	---
RP9	6100	broad.mit.edu	37	7	33139022	33139022	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:33139022G>A	uc003tdm.2	-	3	228	c.210C>T	c.(208-210)TGC>TGT	p.C70C		NM_203288	NP_976033	Q8TA86	RP9_HUMAN	retinitis pigmentosa 9	70	PIM1-binding (By similarity).				RNA splicing	nucleus	nucleic acid binding|protein binding|zinc ion binding				0			GBM - Glioblastoma multiforme(11;0.0403)															---	---	---	---
HERPUD2	64224	broad.mit.edu	37	7	35673349	35673349	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:35673349G>A	uc003tet.2	-	8	1977	c.1172C>T	c.(1171-1173)ACC>ATC	p.T391I	HERPUD2_uc003tes.3_Missense_Mutation_p.T391I	NM_022373	NP_071768	Q9BSE4	HERP2_HUMAN	HERPUD family member 2	391					response to unfolded protein	integral to membrane				ovary(3)	3																		---	---	---	---
STARD3NL	83930	broad.mit.edu	37	7	38268436	38268436	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:38268436A>G	uc003tfr.2	+	8	834	c.686A>G	c.(685-687)AAA>AGA	p.K229R	STARD3NL_uc003tfs.2_Missense_Mutation_p.K229R|STARD3NL_uc003tft.2_Missense_Mutation_p.K211R	NM_032016	NP_114405	O95772	MENTO_HUMAN	MLN64 N-terminal homolog	229	Cytoplasmic (Potential).					integral to membrane|late endosome membrane				ovary(1)	1																		---	---	---	---
GLI3	2737	broad.mit.edu	37	7	42004864	42004864	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:42004864G>A	uc011kbh.1	-	15	3898	c.3807C>T	c.(3805-3807)GAC>GAT	p.D1269D	GLI3_uc011kbg.1_Silent_p.D1210D	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1269					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19														Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				---	---	---	---
HECW1	23072	broad.mit.edu	37	7	43447289	43447289	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:43447289A>G	uc003tid.1	+	8	1365	c.760A>G	c.(760-762)AAG>GAG	p.K254E	HECW1_uc011kbi.1_Missense_Mutation_p.K254E|HECW1_uc003tie.1_Missense_Mutation_p.K286E	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	254	C2.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23																		---	---	---	---
EGFR	1956	broad.mit.edu	37	7	55229284	55229284	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:55229284C>T	uc003tqk.2	+	13	1837	c.1591C>T	c.(1591-1593)CGA>TGA	p.R531*	EGFR_uc003tqi.2_Nonsense_Mutation_p.R531*|EGFR_uc003tqj.2_Nonsense_Mutation_p.R531*|EGFR_uc010kzg.1_Nonsense_Mutation_p.R486*|EGFR_uc011kco.1_Nonsense_Mutation_p.R478*|EGFR_uc011kcp.1_Intron|EGFR_uc011kcq.1_Intron	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	531	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			---	---	---	---
CRCP	27297	broad.mit.edu	37	7	65595732	65595732	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:65595732T>C	uc003tus.2	+	3	192	c.47T>C	c.(46-48)GTA>GCA	p.V16A	CRCP_uc003tuv.2_RNA|CRCP_uc011kdw.1_Intron|CRCP_uc003tut.2_Intron|CRCP_uc003tuu.2_Intron	NM_014478	NP_055293	O75575	RPC9_HUMAN	calcitonin gene-related peptide-receptor	16					acrosome reaction|innate immune response|response to virus|transcription from RNA polymerase III promoter	DNA polymerase III complex|nucleus|plasma membrane	calcitonin receptor activity|DNA-directed RNA polymerase activity|nucleotide binding				0																		---	---	---	---
AUTS2	26053	broad.mit.edu	37	7	69064844	69064844	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:69064844C>T	uc003tvw.3	+	1	948	c.205C>T	c.(205-207)CGG>TGG	p.R69W	AUTS2_uc003tvv.3_Missense_Mutation_p.R69W|AUTS2_uc003tvx.3_Missense_Mutation_p.R69W	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	69										ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)														---	---	---	---
AUTS2	26053	broad.mit.edu	37	7	70236607	70236607	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:70236607C>A	uc003tvw.3	+	11	2550	c.1807C>A	c.(1807-1809)CTA>ATA	p.L603I	AUTS2_uc003tvx.3_Missense_Mutation_p.L603I|AUTS2_uc011keg.1_Missense_Mutation_p.L55I	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	603										ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)														---	---	---	---
WBSCR17	64409	broad.mit.edu	37	7	70597946	70597946	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:70597946C>T	uc003tvy.2	+	1	158	c.158C>T	c.(157-159)GCG>GTG	p.A53V		NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	53	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)																---	---	---	---
WBSCR28	135886	broad.mit.edu	37	7	73279593	73279593	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:73279593A>G	uc003tzk.2	+	2	379	c.343A>G	c.(343-345)AGT>GGT	p.S115G	RFC2_uc011kfa.1_Intron|WBSCR28_uc003tzl.2_Missense_Mutation_p.S14G	NM_182504	NP_872310	Q6UE05	WBS28_HUMAN	hypothetical protein LOC135886	115						integral to membrane				breast(1)	1		Lung NSC(55;0.159)																---	---	---	---
HGF	3082	broad.mit.edu	37	7	81372788	81372788	+	Splice_Site	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:81372788C>T	uc003uhl.2	-	7	912	c.747_splice	c.e7-1	p.R249_splice	HGF_uc003uhm.2_Splice_Site_p.R244_splice|HGF_uc003uhn.1_Splice_Site_p.R249_splice|HGF_uc003uho.1_Splice_Site_p.R244_splice	NM_000601	NP_000592			hepatocyte growth factor isoform 1						epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4																		---	---	---	---
PCLO	27445	broad.mit.edu	37	7	82785096	82785096	+	Silent	SNP	G	A	A	rs61744360	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:82785096G>A	uc003uhx.2	-	2	1150	c.861C>T	c.(859-861)GAC>GAT	p.D287D	PCLO_uc003uhv.2_Silent_p.D287D	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	287	Gln-rich.|Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7																		---	---	---	---
PEX1	5189	broad.mit.edu	37	7	92134057	92134057	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:92134057C>T	uc003uly.2	-	12	2156	c.2060G>A	c.(2059-2061)CGG>CAG	p.R687Q	PEX1_uc011khr.1_Missense_Mutation_p.R479Q|PEX1_uc010ley.2_Intron|PEX1_uc011khs.1_Missense_Mutation_p.R365Q|PEX1_uc011kht.1_RNA	NM_000466	NP_000457	O43933	PEX1_HUMAN	peroxin1	687			Missing (in NALD).		microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)|central_nervous_system(1)	2	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)															---	---	---	---
SAMD9L	219285	broad.mit.edu	37	7	92762390	92762390	+	Silent	SNP	T	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:92762390T>A	uc003umh.1	-	5	4111	c.2895A>T	c.(2893-2895)GGA>GGT	p.G965G	SAMD9L_uc003umj.1_Silent_p.G965G|SAMD9L_uc003umi.1_Silent_p.G965G|SAMD9L_uc010lfb.1_Silent_p.G965G|SAMD9L_uc003umk.1_Silent_p.G965G|SAMD9L_uc010lfc.1_Silent_p.G965G|SAMD9L_uc010lfd.1_Silent_p.G965G|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	965										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)															---	---	---	---
COL1A2	1278	broad.mit.edu	37	7	94040372	94040372	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:94040372C>A	uc003ung.1	+	23	1727	c.1256C>A	c.(1255-1257)CCT>CAT	p.P419H	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	419					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)										HNSCC(75;0.22)			---	---	---	---
TRRAP	8295	broad.mit.edu	37	7	98608719	98608719	+	Silent	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:98608719G>T	uc003upp.2	+	70	11150	c.10941G>T	c.(10939-10941)CCG>CCT	p.P3647P	TRRAP_uc011kis.1_Silent_p.P3618P|TRRAP_uc003upr.2_Silent_p.P3353P|TRRAP_uc003ups.2_5'Flank	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	3647	PI3K/PI4K.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)															---	---	---	---
CYP3A7	1551	broad.mit.edu	37	7	99313472	99313472	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99313472G>A	uc003uru.2	-	7	684	c.579C>T	c.(577-579)ATC>ATT	p.I193I	ZNF498_uc003urn.2_Intron|CYP3A5_uc003urs.2_Intron|CYP3A5_uc010lgg.2_Intron	NM_000765	NP_000756	P24462	CP3A7_HUMAN	cytochrome P450, family 3, subfamily A,	193					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)	1	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)																	---	---	---	---
TRIP6	7205	broad.mit.edu	37	7	100468329	100468329	+	Silent	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100468329C>A	uc003uww.2	+	6	1133	c.963C>A	c.(961-963)GCC>GCA	p.A321A	TRIP6_uc010lhk.1_RNA	NM_003302	NP_003293	Q15654	TRIP6_HUMAN	thyroid receptor-interacting protein 6	321					focal adhesion assembly|positive regulation of cell migration|regulation of transcription, DNA-dependent|release of cytoplasmic sequestered NF-kappaB|transcription, DNA-dependent	cytoplasm|cytoskeleton|focal adhesion|nucleus	identical protein binding|interleukin-1 receptor binding|kinase binding|thyroid hormone receptor binding|zinc ion binding			central_nervous_system(2)	2	Lung NSC(181;0.041)|all_lung(186;0.0581)																	---	---	---	---
SRRT	51593	broad.mit.edu	37	7	100479844	100479844	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100479844C>G	uc003uwy.2	+	6	837	c.569C>G	c.(568-570)GCG>GGG	p.A190G	SRRT_uc010lhl.1_Missense_Mutation_p.A190G|SRRT_uc003uxa.2_Missense_Mutation_p.A190G|SRRT_uc003uwz.2_Missense_Mutation_p.A190G	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	190					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2																		---	---	---	---
ACHE	43	broad.mit.edu	37	7	100488859	100488859	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100488859G>A	uc003uxd.2	-	3	1810	c.1654C>T	c.(1654-1656)CGG>TGG	p.R552W	UFSP1_uc003uxc.3_5'Flank|ACHE_uc003uxe.2_Missense_Mutation_p.R552W|ACHE_uc003uxf.2_Missense_Mutation_p.R552W|ACHE_uc003uxg.2_Missense_Mutation_p.R552W|ACHE_uc003uxh.2_Missense_Mutation_p.R464W|ACHE_uc003uxi.2_Missense_Mutation_p.R552W	NM_000665	NP_000656	P22303	ACES_HUMAN	acetylcholinesterase isoform E4-E6 precursor	552					acetylcholine catabolic process in synaptic cleft|amyloid precursor protein metabolic process|cell adhesion|cell proliferation|choline metabolic process|DNA replication|muscle organ development|neurotransmitter biosynthetic process|osteoblast development|positive regulation of protein secretion|regulation of axonogenesis|regulation of dendrite morphogenesis|response to wounding|synapse assembly	anchored to membrane|axon|basal lamina|cell junction|cell surface|dendrite|endoplasmic reticulum lumen|extracellular space|Golgi apparatus|neuromuscular junction|nucleus|perinuclear region of cytoplasm|postsynaptic membrane|presynaptic membrane|synaptic cleft	acetylcholine binding|acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|collagen binding|laminin-1 binding|protein homodimerization activity|serine hydrolase activity			skin(2)	2	Lung NSC(181;0.041)|all_lung(186;0.0581)				Ambenonium(DB01122)|Atropine(DB00572)|Choline(DB00122)|Decamethonium(DB01245)|Demecarium bromide(DB00944)|Donepezil(DB00843)|Edrophonium(DB01010)|Ephedrine(DB01364)|Galantamine(DB00674)|Gallamine Triethiodide(DB00483)|Isoflurophate(DB00677)|Neostigmine(DB01400)|Physostigmine(DB00981)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Tacrine(DB00382)|Tubocurarine(DB01199)													---	---	---	---
AP1S1	1174	broad.mit.edu	37	7	100800008	100800008	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100800008T>C	uc003uxv.3	+	2	247	c.137T>C	c.(136-138)ATG>ACG	p.M46T		NM_001283	NP_001274	P61966	AP1S1_HUMAN	adaptor-related protein complex 1, sigma 1	46					intracellular protein transport|post-Golgi vesicle-mediated transport|receptor-mediated endocytosis|regulation of defense response to virus by virus|response to virus|viral reproduction	AP-1 adaptor complex|coated pit|cytosol|lysosomal membrane	protein binding|protein transporter activity				0	Lung NSC(181;0.168)|all_lung(186;0.215)																	---	---	---	---
DNAJC2	27000	broad.mit.edu	37	7	102962984	102962984	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:102962984G>A	uc003vbo.2	-	9	1158	c.907C>T	c.(907-909)CGG>TGG	p.R303W	PMPCB_uc011kll.1_Intron|DNAJC2_uc003vbn.2_Translation_Start_Site|DNAJC2_uc010lix.2_Missense_Mutation_p.R303W|DNAJC2_uc003vbp.2_Translation_Start_Site	NM_014377	NP_055192	Q99543	DNJC2_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 2	303					'de novo' cotranslational protein folding|chromatin modification|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nuclear membrane	chromatin binding|DNA binding|histone binding|Hsp70 protein binding|ubiquitin binding			kidney(1)	1																		---	---	---	---
MLL5	55904	broad.mit.edu	37	7	104753246	104753246	+	Silent	SNP	A	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:104753246A>T	uc003vcm.2	+	27	5577	c.5043A>T	c.(5041-5043)CCA>CCT	p.P1681P	MLL5_uc010ljc.2_Silent_p.P1681P|MLL5_uc010ljf.1_Intron|MLL5_uc010ljg.2_Silent_p.P415P	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	1681	Pro-rich.				cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3																		---	---	---	---
SRPK2	6733	broad.mit.edu	37	7	104783602	104783602	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:104783602T>C	uc003vct.2	-	9	1143	c.956A>G	c.(955-957)TAC>TGC	p.Y319C	SRPK2_uc003vcu.2_Missense_Mutation_p.Y319C|SRPK2_uc003vcv.2_Missense_Mutation_p.Y330C|SRPK2_uc003vcw.1_Missense_Mutation_p.Y319C	NM_182691	NP_872633	P78362	SRPK2_HUMAN	serine/arginine-rich protein-specific kinase 2	319	Protein kinase.				angiogenesis|cell differentiation|intracellular protein kinase cascade|negative regulation of viral genome replication|nuclear speck organization|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of gene expression|positive regulation of neuron apoptosis|positive regulation of viral genome replication|spliceosome assembly	cytoplasm|nucleolus	14-3-3 protein binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(3)|ovary(2)|upper_aerodigestive_tract(1)	6																		---	---	---	---
CDHR3	222256	broad.mit.edu	37	7	105656435	105656435	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:105656435C>T	uc003vdl.3	+	11	1498	c.1390C>T	c.(1390-1392)CCA>TCA	p.P464S	CDHR3_uc003vdk.2_Missense_Mutation_p.P112S|CDHR3_uc003vdm.3_Missense_Mutation_p.P451S|CDHR3_uc011klt.1_Missense_Mutation_p.P376S|CDHR3_uc003vdn.2_Missense_Mutation_p.P181S	NM_152750	NP_689963	Q6ZTQ4	CDHR3_HUMAN	hypothetical protein LOC222256 precursor	464	Cadherin 4.|Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1																		---	---	---	---
DOCK4	9732	broad.mit.edu	37	7	111540481	111540481	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:111540481C>T	uc003vfx.2	-	15	1698	c.1429G>A	c.(1429-1431)GTG>ATG	p.V477M	DOCK4_uc003vfy.2_Missense_Mutation_p.V477M|DOCK4_uc003vga.1_Missense_Mutation_p.V82M	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	477	DHR-1.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)																---	---	---	---
TMEM168	64418	broad.mit.edu	37	7	112423986	112423986	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:112423986A>G	uc003vgn.2	-	2	1287	c.895T>C	c.(895-897)TCC>CCC	p.S299P	TMEM168_uc010lju.2_Missense_Mutation_p.S299P|TMEM168_uc011kmr.1_Intron	NM_022484	NP_071929	Q9H0V1	TM168_HUMAN	transmembrane protein 168	299	Helical; (Potential).					integral to membrane|transport vesicle				ovary(1)|central_nervous_system(1)	2																		---	---	---	---
CTTNBP2	83992	broad.mit.edu	37	7	117432425	117432425	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:117432425G>A	uc003vjf.2	-	4	917	c.825C>T	c.(823-825)AGC>AGT	p.S275S		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	275	Potential.									ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)														---	---	---	---
C7orf58	79974	broad.mit.edu	37	7	120629903	120629903	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:120629903T>C	uc003vjq.3	+	2	675	c.228T>C	c.(226-228)GGT>GGC	p.G76G	C7orf58_uc003vjr.1_Silent_p.G76G|C7orf58_uc003vjs.3_Silent_p.G76G	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	76						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)																	---	---	---	---
PTPRZ1	5803	broad.mit.edu	37	7	121651782	121651782	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:121651782T>C	uc003vjy.2	+	12	3077	c.2682T>C	c.(2680-2682)AGT>AGC	p.S894S	PTPRZ1_uc003vjz.2_Intron|PTPRZ1_uc011knt.1_Intron	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	894	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9																		---	---	---	---
CADPS2	93664	broad.mit.edu	37	7	122033276	122033276	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:122033276C>T	uc010lkp.2	-	21	3145	c.2982G>A	c.(2980-2982)TCG>TCA	p.S994S	CADPS2_uc011knx.1_Silent_p.S369S|CADPS2_uc003vkg.3_Intron|CADPS2_uc010lkq.2_Intron	NM_017954	NP_060424	Q86UW7	CAPS2_HUMAN	Ca2+-dependent activator protein for secretion 2	994	Interaction with DRD2.|MHD1.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
SLC13A1	6561	broad.mit.edu	37	7	122808565	122808565	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:122808565C>G	uc003vkm.2	-	5	629	c.604G>C	c.(604-606)GTT>CTT	p.V202L	SLC13A1_uc010lks.2_5'UTR	NM_022444	NP_071889	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate	202						integral to membrane|plasma membrane	sodium:sulfate symporter activity			ovary(2)	2					Succinic acid(DB00139)													---	---	---	---
GRM8	2918	broad.mit.edu	37	7	126746712	126746712	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:126746712A>C	uc003vlr.2	-	2	876	c.565T>G	c.(565-567)TAT>GAT	p.Y189D	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.Y189D|GRM8_uc010lkz.1_RNA|GRM8_uc003vlu.1_5'UTR	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	189	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)										HNSCC(24;0.065)			---	---	---	---
ZNF800	168850	broad.mit.edu	37	7	127014002	127014002	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:127014002G>A	uc003vlx.1	-	5	1651	c.1388C>T	c.(1387-1389)CCG>CTG	p.P463L	ZNF800_uc003vlw.1_Missense_Mutation_p.P366L|ZNF800_uc003vly.1_Missense_Mutation_p.P463L|ZNF800_uc010lla.2_Missense_Mutation_p.P463L	NM_176814	NP_789784	Q2TB10	ZN800_HUMAN	zinc finger protein 800	463					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1																		---	---	---	---
FLNC	2318	broad.mit.edu	37	7	128496836	128496836	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:128496836C>T	uc003vnz.3	+	45	7631	c.7422C>T	c.(7420-7422)GGC>GGT	p.G2474G	FLNC_uc003voa.3_Silent_p.G2441G	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	2474	Filamin 22.|Interaction with INPPL1.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12																		---	---	---	---
LRGUK	136332	broad.mit.edu	37	7	133948672	133948672	+	Missense_Mutation	SNP	G	A	A	rs138421011		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:133948672G>A	uc003vrm.1	+	20	2439	c.2423G>A	c.(2422-2424)CGC>CAC	p.R808H		NM_144648	NP_653249	Q96M69	LRGUK_HUMAN	leucine-rich repeats and guanylate kinase domain	808							ATP binding|kinase activity			lung(2)|skin(2)|kidney(1)	5																		---	---	---	---
TRIM24	8805	broad.mit.edu	37	7	138145487	138145487	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:138145487G>A	uc003vuc.2	+	1	409	c.194G>A	c.(193-195)AGC>AAC	p.S65N	TRIM24_uc003vub.2_Missense_Mutation_p.S65N	NM_015905	NP_056989	O15164	TIF1A_HUMAN	transcriptional intermediary factor 1 alpha	65	RING-type.				cellular response to estrogen stimulus|protein catabolic process|regulation of apoptosis|regulation of protein stability|transcription from RNA polymerase II promoter	cytoplasm	chromatin binding|estrogen response element binding|histone acetyl-lysine binding|p53 binding|transcription coactivator activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(3)|ovary(2)|stomach(1)|breast(1)|skin(1)	8																		---	---	---	---
ATP6V0A4	50617	broad.mit.edu	37	7	138394473	138394473	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:138394473G>A	uc003vuf.2	-	20	2563	c.2325C>T	c.(2323-2325)ATC>ATT	p.I775I	ATP6V0A4_uc003vug.2_Silent_p.I775I|ATP6V0A4_uc003vuh.2_Silent_p.I775I	NM_130841	NP_570856	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit	775	Helical; (Potential).				cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			pancreas(1)	1																		---	---	---	---
ZC3HAV1	56829	broad.mit.edu	37	7	138764890	138764890	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:138764890G>A	uc003vun.2	-	4	1185	c.797C>T	c.(796-798)GCG>GTG	p.A266V	ZC3HAV1_uc003vuo.2_5'Flank|ZC3HAV1_uc003vup.2_Missense_Mutation_p.A266V	NM_020119	NP_064504	Q7Z2W4	ZCCHV_HUMAN	zinc finger antiviral protein isoform 1	266					response to virus	cytoplasm|nucleus	NAD+ ADP-ribosyltransferase activity|RNA binding|zinc ion binding			ovary(1)	1																		---	---	---	---
TTC26	79989	broad.mit.edu	37	7	138872157	138872157	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:138872157C>T	uc003vus.2	+	17	1539	c.1425C>T	c.(1423-1425)GGC>GGT	p.G475G	TTC26_uc011kqn.1_Intron|TTC26_uc011kqo.1_Silent_p.G444G|TTC26_uc011kqp.1_Silent_p.G370G|TTC26_uc003vut.2_Silent_p.G335G|TTC26_uc011kqq.1_Silent_p.G344G	NM_024926	NP_079202	A0AVF1	TTC26_HUMAN	tetratricopeptide repeat domain 26 isoform 1	475	TPR 4.						binding			ovary(1)	1																		---	---	---	---
LUC7L2	51631	broad.mit.edu	37	7	139107068	139107068	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:139107068C>T	uc003vux.2	+	10	1535	c.1161C>T	c.(1159-1161)CGC>CGT	p.R387R	LUC7L2_uc011kqs.1_Silent_p.R384R|LUC7L2_uc011kqt.1_Silent_p.R453R|LUC7L2_uc003vuy.2_Silent_p.R386R|LUC7L2_uc003vva.2_Silent_p.R334R	NM_016019	NP_057103	Q9Y383	LC7L2_HUMAN	LUC7-like 2	387	Arg/Ser-rich.						enzyme binding|metal ion binding				0	Melanoma(164;0.242)																	---	---	---	---
BRAF	673	broad.mit.edu	37	7	140500184	140500184	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:140500184C>T	uc003vwc.3	-	7	1019	c.958G>A	c.(958-960)GCA>ACA	p.A320T		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	320					activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)		61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				---	---	---	---
Unknown	0	broad.mit.edu	37	7	142494849	142494849	+	RNA	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:142494849C>T	uc011ksh.1	+	2		c.102C>T			uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_RNA|uc003wag.1_Intron|uc003wan.1_5'Flank|uc003wbe.3_Intron|uc003wbf.3_Intron|uc003wbg.3_Intron|uc003wbh.3_Intron|uc003wbi.3_Intron|uc003wbj.3_Intron|uc003wbm.3_RNA|uc003wbn.3_5'Flank|uc010los.2_5'Flank					Homo sapiens mRNA for T-cell receptor beta chain, partial cds, clone:TCRVB.3.																														---	---	---	---
EPHA1	2041	broad.mit.edu	37	7	143095886	143095886	+	Missense_Mutation	SNP	G	C	C	rs57652656	byFrequency;by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:143095886G>C	uc003wcz.2	-	6	1231	c.1144C>G	c.(1144-1146)CCC>GCC	p.P382A		NM_005232	NP_005223	P21709	EPHA1_HUMAN	ephrin receptor EphA1 precursor	382	Extracellular (Potential).|Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity			ovary(3)|lung(1)|breast(1)	5	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)																---	---	---	---
OR2A5	393046	broad.mit.edu	37	7	143748348	143748348	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:143748348T>G	uc011ktw.1	+	1	854	c.854T>G	c.(853-855)CTG>CGG	p.L285R		NM_012365	NP_036497	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A,	285	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Melanoma(164;0.0783)																	---	---	---	---
CNTNAP2	26047	broad.mit.edu	37	7	146997331	146997331	+	Silent	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:146997331C>A	uc003weu.1	+	9	1963	c.1447C>A	c.(1447-1449)CGA>AGA	p.R483R		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	483	Extracellular (Potential).|Laminin G-like 2.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)												HNSCC(39;0.1)			---	---	---	---
ZNF282	8427	broad.mit.edu	37	7	148910865	148910865	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:148910865G>A	uc003wfm.2	+	7	1244	c.1139G>A	c.(1138-1140)CGC>CAC	p.R380H	ZNF282_uc011kun.1_Missense_Mutation_p.R380H|ZNF282_uc003wfn.2_Missense_Mutation_p.R320H|ZNF282_uc003wfo.2_Intron	NM_003575	NP_003566	Q9UDV7	ZN282_HUMAN	zinc finger protein 282	380					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)	Lung(243;0.145)														---	---	---	---
GIMAP1	170575	broad.mit.edu	37	7	150417708	150417708	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:150417708G>T	uc003whq.2	+	3	703	c.616G>T	c.(616-618)GGG>TGG	p.G206W	GIMAP1_uc003whp.2_Missense_Mutation_p.G214W	NM_130759	NP_570115	Q8WWP7	GIMA1_HUMAN	GTPase, IMAP family member 1	206	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	GTP binding			ovary(1)|breast(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)														---	---	---	---
NOS3	4846	broad.mit.edu	37	7	150711125	150711125	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:150711125C>T	uc003wif.2	+	27	3776	c.3480C>T	c.(3478-3480)TTC>TTT	p.F1160F	NOS3_uc011kuy.1_Silent_p.F954F|ATG9B_uc003wig.3_Intron|ATG9B_uc011kvc.1_Intron	NM_000603	NP_000594	P29474	NOS3_HUMAN	nitric oxide synthase 3 isoform 1	1160					anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			central_nervous_system(5)|large_intestine(2)|skin(1)	8	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)													---	---	---	---
CHPF2	54480	broad.mit.edu	37	7	150932267	150932267	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:150932267T>C	uc003wjr.1	+	2	1910	c.397T>C	c.(397-399)TAC>CAC	p.Y133H	CHPF2_uc003wjq.1_Missense_Mutation_p.Y125H	NM_019015	NP_061888	Q9P2E5	CHPF2_HUMAN	chondroitin polymerizing factor 2	133	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			ovary(1)	1																		---	---	---	---
CRYGN	155051	broad.mit.edu	37	7	151127139	151127139	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:151127139G>T	uc003wke.2	-	4	640	c.544C>A	c.(544-546)CTC>ATC	p.L182I	CRYGN_uc003wkf.2_3'UTR|CRYGN_uc003wkg.2_RNA	NM_144727	NP_653328	Q8WXF5	CRGN_HUMAN	gammaN-crystallin	182											0			OV - Ovarian serous cystadenocarcinoma(82;0.00358)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)														---	---	---	---
Unknown	0	broad.mit.edu	37	7	152143605	152143605	+	IGR	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:152143605G>T								FABP5L3 (3507 upstream) : LOC100128822 (17604 downstream)																																			---	---	---	---
PAXIP1	22976	broad.mit.edu	37	7	154754138	154754138	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:154754138C>T	uc003wlp.2	-	10	2063	c.2020G>A	c.(2020-2022)GCA>ACA	p.A674T	PAXIP1_uc003wlq.1_Missense_Mutation_p.A640T|PAXIP1_uc011kvs.1_Missense_Mutation_p.A638T	NM_007349	NP_031375	Q6ZW49	PAXI1_HUMAN	PAX interacting protein 1	674	Interaction with TP53BP1.|BRCT 3.				DNA damage response, signal transduction by p53 class mediator|DNA recombination|DNA repair|histone H3-K4 methylation|positive regulation of histone acetylation|positive regulation of histone H3-K36 methylation|positive regulation of histone H3-K4 methylation|positive regulation of isotype switching|positive regulation of protein ubiquitination|positive regulation of transcription initiation from RNA polymerase II promoter|response to ionizing radiation|transcription, DNA-dependent	histone methyltransferase complex|nuclear matrix				lung(2)|ovary(1)|breast(1)|pancreas(1)	5	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0296)	UCEC - Uterine corpus endometrioid carcinoma (81;0.178)														---	---	---	---
LMBR1	64327	broad.mit.edu	37	7	156554834	156554834	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:156554834C>A	uc003wmw.3	-	8	893	c.678G>T	c.(676-678)AAG>AAT	p.K226N	LMBR1_uc003wmv.3_Missense_Mutation_p.K74N|LMBR1_uc003wmx.3_Missense_Mutation_p.K74N|LMBR1_uc010lqn.2_Missense_Mutation_p.K226N|LMBR1_uc011kvx.1_Missense_Mutation_p.K205N	NM_022458	NP_071903	Q8WVP7	LMBR1_HUMAN	limb region 1 protein	226	Cytoplasmic (Potential).					integral to membrane	receptor activity				0	Ovarian(565;0.218)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.208)														---	---	---	---
NOM1	64434	broad.mit.edu	37	7	156746803	156746803	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:156746803T>C	uc003wmy.2	+	3	1134	c.1119T>C	c.(1117-1119)AGT>AGC	p.S373S		NM_138400	NP_612409	Q5C9Z4	NOM1_HUMAN	nucleolar protein with MIF4G domain 1	373	MIF4G.				RNA metabolic process	nucleolus	protein binding				0	Ovarian(565;0.218)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00301)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)														---	---	---	---
UBE3C	9690	broad.mit.edu	37	7	157049683	157049683	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:157049683G>A	uc010lqs.2	+	22	3338	c.3026G>A	c.(3025-3027)CGC>CAC	p.R1009H	UBE3C_uc003wni.3_Missense_Mutation_p.R372H	NM_014671	NP_055486	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	1009	HECT.				protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(2)|large_intestine(1)	5		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)														---	---	---	---
DNAJB6	10049	broad.mit.edu	37	7	157177588	157177588	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:157177588A>G	uc003wnk.2	+	7	660	c.506A>G	c.(505-507)CAC>CGC	p.H169R	DNAJB6_uc003wnj.2_Missense_Mutation_p.H169R|DNAJB6_uc003wnl.2_Missense_Mutation_p.H156R|DNAJB6_uc011kvy.1_Missense_Mutation_p.H120R|DNAJB6_uc011kvz.1_Intron|DNAJB6_uc010lqt.2_Missense_Mutation_p.H169R	NM_058246	NP_490647	O75190	DNJB6_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 6	169	Gly/Phe-rich.|Interaction with KRT18.				intermediate filament organization|negative regulation of caspase activity|protein folding|response to unfolded protein	nucleus|perinuclear region of cytoplasm	ATPase activator activity|chaperone binding|heat shock protein binding|unfolded protein binding			ovary(2)	2	all_neural(206;0.181)	all_epithelial(9;0.000606)|all_hematologic(28;0.00287)|Acute lymphoblastic leukemia(9;0.0647)|Ovarian(593;0.196)	OV - Ovarian serous cystadenocarcinoma(82;0.00399)	UCEC - Uterine corpus endometrioid carcinoma (81;0.172)														---	---	---	---
MYOM2	9172	broad.mit.edu	37	8	2056577	2056577	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:2056577A>G	uc003wpx.3	+	24	3137	c.2999A>G	c.(2998-3000)GAG>GGG	p.E1000G	MYOM2_uc011kwi.1_Missense_Mutation_p.E425G	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	1000	Ig-like C2-type 3.				muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)														---	---	---	---
CSMD1	64478	broad.mit.edu	37	8	2818731	2818731	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:2818731C>A	uc011kwk.1	-	62	10027	c.9637G>T	c.(9637-9639)GCT>TCT	p.A3213S	CSMD1_uc011kwj.1_Missense_Mutation_p.A2542S|CSMD1_uc010lrg.2_Missense_Mutation_p.A1104S	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	3213	Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)														---	---	---	---
CSMD1	64478	broad.mit.edu	37	8	2886894	2886894	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:2886894C>T	uc011kwk.1	-	51	8195	c.7805G>A	c.(7804-7806)CGG>CAG	p.R2602Q	CSMD1_uc011kwj.1_Missense_Mutation_p.R1931Q|CSMD1_uc010lrg.2_Missense_Mutation_p.R670Q	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2602	Extracellular (Potential).|Sushi 16.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)														---	---	---	---
CSMD1	64478	broad.mit.edu	37	8	3855606	3855606	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:3855606G>A	uc011kwk.1	-	5	1027	c.637C>T	c.(637-639)CGC>TGC	p.R213C		NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	213	Extracellular (Potential).|CUB 2.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)														---	---	---	---
ANGPT2	285	broad.mit.edu	37	8	6420295	6420295	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:6420295C>T	uc003wqj.3	-	1	490	c.161G>A	c.(160-162)CGC>CAC	p.R54H	MCPH1_uc003wqi.2_Intron|ANGPT2_uc003wqk.3_Missense_Mutation_p.R54H|ANGPT2_uc010lri.2_Missense_Mutation_p.R54H|ANGPT2_uc003wql.3_Missense_Mutation_p.R54H	NM_001147	NP_001138	O15123	ANGP2_HUMAN	angiopoietin 2 isoform a precursor	54					angiogenesis|blood coagulation|leukocyte migration|negative regulation of blood vessel endothelial cell migration|negative regulation of positive chemotaxis|Tie receptor signaling pathway	extracellular space	metal ion binding|receptor tyrosine kinase binding			upper_aerodigestive_tract(1)	1		Hepatocellular(245;0.0663)		Colorectal(4;0.0142)|READ - Rectum adenocarcinoma(4;0.19)|COAD - Colon adenocarcinoma(4;0.226)														---	---	---	---
SGK223	157285	broad.mit.edu	37	8	8185961	8185961	+	Silent	SNP	C	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:8185961C>G	uc003wsh.3	-	4	2331	c.2331G>C	c.(2329-2331)CTG>CTC	p.L777L		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	777							ATP binding|non-membrane spanning protein tyrosine kinase activity				0																		---	---	---	---
SGK223	157285	broad.mit.edu	37	8	8234853	8234853	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:8234853C>T	uc003wsh.3	-	2	1066	c.1066G>A	c.(1066-1068)GTC>ATC	p.V356I		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	356							ATP binding|non-membrane spanning protein tyrosine kinase activity				0																		---	---	---	---
DLC1	10395	broad.mit.edu	37	8	12950293	12950293	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:12950293T>A	uc003wwm.2	-	13	4012	c.3568A>T	c.(3568-3570)ATC>TTC	p.I1190F	DLC1_uc003wwk.1_Missense_Mutation_p.I753F|DLC1_uc003wwl.1_Missense_Mutation_p.I787F|DLC1_uc011kxx.1_Missense_Mutation_p.I679F	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	1190	Rho-GAP.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7																		---	---	---	---
DLC1	10395	broad.mit.edu	37	8	12957673	12957673	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:12957673T>C	uc003wwm.2	-	9	2617	c.2173A>G	c.(2173-2175)AAC>GAC	p.N725D	DLC1_uc003wwk.1_Missense_Mutation_p.N288D|DLC1_uc003wwl.1_Missense_Mutation_p.N322D|DLC1_uc011kxx.1_Missense_Mutation_p.N214D	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	725					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7																		---	---	---	---
LPL	4023	broad.mit.edu	37	8	19816811	19816811	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:19816811G>C	uc003wzk.3	+	7	1429	c.1059G>C	c.(1057-1059)GAG>GAC	p.E353D		NM_000237	NP_000228	P06858	LIPL_HUMAN	lipoprotein lipase precursor	353	PLAT.|Heparin-binding (By similarity).				fatty acid biosynthetic process|lipoprotein metabolic process|phospholipid metabolic process|positive regulation of cholesterol storage|positive regulation of sequestering of triglyceride|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	anchored to membrane|chylomicron|plasma membrane|very-low-density lipoprotein particle	heparin binding|lipoprotein lipase activity|phospholipase activity|receptor binding|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	Clofibrate(DB00636)|Gemfibrozil(DB01241)|Orlistat(DB01083)													---	---	---	---
ATP6V1B2	526	broad.mit.edu	37	8	20067853	20067853	+	Intron	SNP	A	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:20067853A>C	uc003wzp.2	+							NM_001693	NP_001684			vacuolar H+ATPase B2						ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|endomembrane system|Golgi apparatus|melanosome|plasma membrane|proton-transporting V-type ATPase, V1 domain	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism				0				Colorectal(74;0.0535)|COAD - Colon adenocarcinoma(73;0.211)														---	---	---	---
XPO7	23039	broad.mit.edu	37	8	21840230	21840230	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:21840230A>G	uc003xaa.3	+	11	1286	c.1184A>G	c.(1183-1185)AAA>AGA	p.K395R	XPO7_uc010lti.2_Missense_Mutation_p.K404R|XPO7_uc010ltk.2_Missense_Mutation_p.K396R	NM_015024	NP_055839	Q9UIA9	XPO7_HUMAN	exportin 7 isoform b	395				Missing (in Ref. 3; BAA34465).	mRNA transport|protein export from nucleus|transmembrane transport	cytoplasm|nuclear pore	nuclear export signal receptor activity|protein transporter activity			ovary(1)|kidney(1)|breast(1)|central_nervous_system(1)|pancreas(1)	5				Colorectal(74;0.0187)|COAD - Colon adenocarcinoma(73;0.0724)														---	---	---	---
EGR3	1960	broad.mit.edu	37	8	22550362	22550362	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:22550362C>T	uc003xcm.1	-	1	454	c.96G>A	c.(94-96)GCG>GCA	p.A32A	EGR3_uc011kzn.1_5'Flank|EGR3_uc011kzo.1_5'Flank	NM_004430	NP_004421	Q06889	EGR3_HUMAN	early growth response 3	32					circadian rhythm|muscle organ development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Prostate(55;0.0421)|Breast(100;0.102)		Colorectal(74;0.0145)|BRCA - Breast invasive adenocarcinoma(99;0.053)|COAD - Colon adenocarcinoma(73;0.0608)														---	---	---	---
SLC25A37	51312	broad.mit.edu	37	8	23429052	23429052	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:23429052C>A	uc003xdo.2	+	4	854	c.701C>A	c.(700-702)CCG>CAG	p.P234Q	SLC25A37_uc003xdp.2_RNA|SLC25A37_uc010ltz.2_RNA|SLC25A37_uc003xdq.2_RNA|SLC25A37_uc003xdr.1_RNA|uc003xds.2_5'Flank	NM_016612	NP_057696	Q9NYZ2	MFRN1_HUMAN	solute carrier family 25, member 37	234	Solcar 3.|Helical; Name=5; (Potential).				ion transport|iron ion homeostasis	integral to membrane|mitochondrial inner membrane					0		Prostate(55;0.114)		Colorectal(74;0.0198)|COAD - Colon adenocarcinoma(73;0.0751)														---	---	---	---
CDCA2	157313	broad.mit.edu	37	8	25325861	25325861	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:25325861G>A	uc003xep.1	+	6	1146	c.667G>A	c.(667-669)GGT>AGT	p.G223S	PPP2R2A_uc003xek.2_Intron|CDCA2_uc011lae.1_Missense_Mutation_p.G223S|CDCA2_uc003xeq.1_Missense_Mutation_p.G208S|CDCA2_uc003xer.1_5'UTR	NM_152562	NP_689775	Q69YH5	CDCA2_HUMAN	cell division cycle associated 2	223					cell division|mitosis	cytoplasm|nucleus					0		all_cancers(63;0.0378)|Ovarian(32;0.000878)|all_epithelial(46;0.0162)|Breast(100;0.0164)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.022)|Epithelial(17;1.37e-11)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0443)														---	---	---	---
CDCA2	157313	broad.mit.edu	37	8	25364584	25364584	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:25364584C>T	uc003xep.1	+	15	2881	c.2402C>T	c.(2401-2403)ACG>ATG	p.T801M	PPP2R2A_uc003xek.2_Intron|CDCA2_uc011lae.1_3'UTR|CDCA2_uc003xeq.1_Missense_Mutation_p.T786M|CDCA2_uc003xer.1_Missense_Mutation_p.T464M	NM_152562	NP_689775	Q69YH5	CDCA2_HUMAN	cell division cycle associated 2	801					cell division|mitosis	cytoplasm|nucleus					0		all_cancers(63;0.0378)|Ovarian(32;0.000878)|all_epithelial(46;0.0162)|Breast(100;0.0164)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.022)|Epithelial(17;1.37e-11)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0443)														---	---	---	---
DPYSL2	1808	broad.mit.edu	37	8	26481759	26481759	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:26481759T>C	uc003xfb.1	+	4	764	c.414T>C	c.(412-414)CAT>CAC	p.H138H	DPYSL2_uc003xfa.2_Silent_p.H243H|DPYSL2_uc011lag.1_Silent_p.H138H|DPYSL2_uc010luk.1_RNA|DPYSL2_uc011lah.1_Silent_p.H102H	NM_001386	NP_001377	Q16555	DPYL2_HUMAN	dihydropyrimidinase-like 2	138					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	dihydropyrimidinase activity|protein binding			large_intestine(1)	1		all_cancers(63;0.121)|Ovarian(32;2.68e-05)|all_epithelial(46;0.116)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;3.33e-10)|Colorectal(74;0.183)														---	---	---	---
STMN4	81551	broad.mit.edu	37	8	27097516	27097516	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:27097516G>T	uc003xfk.2	-	5	596	c.482C>A	c.(481-483)GCC>GAC	p.A161D	STMN4_uc003xfj.2_Missense_Mutation_p.A188D|STMN4_uc011lai.1_Missense_Mutation_p.A188D|STMN4_uc011laj.1_Missense_Mutation_p.A152D|STMN4_uc011lak.1_Missense_Mutation_p.A188D|STMN4_uc010luo.2_Missense_Mutation_p.A161D			Q9H169	STMN4_HUMAN	RecName: Full=Stathmin-4; AltName: Full=Stathmin-like protein B3;          Short=RB3;	161	Potential.				intracellular signal transduction					large_intestine(1)|pancreas(1)	2		Ovarian(32;0.00167)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0214)|Epithelial(17;9.82e-10)|Colorectal(74;0.142)														---	---	---	---
EPHX2	2053	broad.mit.edu	37	8	27398071	27398071	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:27398071G>T	uc003xfu.2	+	15	1358	c.1277G>T	c.(1276-1278)GGA>GTA	p.G426V	EPHX2_uc010luu.2_Missense_Mutation_p.G394V|EPHX2_uc010luv.2_Missense_Mutation_p.G360V|EPHX2_uc003xfv.2_Missense_Mutation_p.G373V|EPHX2_uc010luw.2_Missense_Mutation_p.G360V	NM_001979	NP_001970	P34913	HYES_HUMAN	epoxide hydrolase 2, cytoplasmic	426	Epoxide hydrolase.				aromatic compound catabolic process|cellular calcium ion homeostasis|drug metabolic process|inflammatory response|positive regulation of vasodilation|reactive oxygen species metabolic process|regulation of blood pressure|response to toxin|xenobiotic metabolic process	cytosol|focal adhesion|Golgi apparatus|nucleolus|peroxisome|soluble fraction	epoxide hydrolase activity|metal ion binding|protein homodimerization activity			ovary(1)	1		Ovarian(32;2.61e-05)|all_epithelial(46;0.207)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0226)|Epithelial(17;1.12e-09)|Colorectal(74;0.157)	Tamoxifen(DB00675)													---	---	---	---
EXTL3	2137	broad.mit.edu	37	8	28574452	28574452	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:28574452T>C	uc003xgz.1	+	3	1469	c.876T>C	c.(874-876)AGT>AGC	p.S292S		NM_001440	NP_001431	O43909	EXTL3_HUMAN	exostoses-like 3	292	Lumenal (Potential).					integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding|protein binding			skin(2)	2		Ovarian(32;0.069)		KIRC - Kidney renal clear cell carcinoma(542;0.107)|Kidney(114;0.129)|Colorectal(74;0.228)														---	---	---	---
UBXN8	7993	broad.mit.edu	37	8	30620808	30620808	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:30620808C>T	uc003xii.2	+	7	606	c.589C>T	c.(589-591)CGA>TGA	p.R197*	UBXN8_uc010lvi.2_Nonsense_Mutation_p.R160*|UBXN8_uc011lbb.1_RNA|UBXN8_uc003xij.2_RNA	NM_005671	NP_005662	O00124	UBXN8_HUMAN	reproduction 8	197	UBX.				single fertilization						0																		---	---	---	---
PURG	29942	broad.mit.edu	37	8	30889958	30889958	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:30889958T>C	uc003xin.2	-	1	360	c.341A>G	c.(340-342)GAG>GGG	p.E114G	WRN_uc003xio.3_5'Flank|PURG_uc003xim.1_Missense_Mutation_p.E114G	NM_013357	NP_037489	Q9UJV8	PURG_HUMAN	purine-rich element binding protein G isoform A	114	By similarity.					nucleus	DNA binding				0				KIRC - Kidney renal clear cell carcinoma(542;0.0895)|Kidney(114;0.108)														---	---	---	---
UNC5D	137970	broad.mit.edu	37	8	35608257	35608257	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:35608257G>A	uc003xjr.1	+	13	2421	c.2093G>A	c.(2092-2094)TGC>TAC	p.C698Y	UNC5D_uc003xjs.1_Missense_Mutation_p.C693Y|UNC5D_uc003xju.1_Missense_Mutation_p.C274Y	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	698	Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)														---	---	---	---
PLEKHA2	59339	broad.mit.edu	37	8	38775508	38775508	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:38775508A>G	uc003xmi.3	+	2	295	c.61A>G	c.(61-63)AAC>GAC	p.N21D	PLEKHA2_uc011lce.1_Intron	NM_021623	NP_067636	Q9HB19	PKHA2_HUMAN	pleckstrin homology domain containing, family A	21	PH 1.				positive regulation of cell-matrix adhesion	cytoplasm|nucleus|plasma membrane|protein complex	fibronectin binding|laminin binding				0		all_lung(54;0.0413)|Lung NSC(58;0.115)|Hepatocellular(245;0.152)	LUSC - Lung squamous cell carcinoma(45;4.68e-08)|COAD - Colon adenocarcinoma(9;0.235)															---	---	---	---
TM2D2	83877	broad.mit.edu	37	8	38851177	38851177	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:38851177G>A	uc003xmk.2	-	3	401	c.318C>T	c.(316-318)TTC>TTT	p.F106F	TM2D2_uc003xml.2_Silent_p.F63F|TM2D2_uc003xmm.2_Silent_p.F63F|TM2D2_uc003xmn.2_Silent_p.F63F	NM_078473	NP_510882	Q9BX73	TM2D2_HUMAN	TM2 domain containing 2 isoform a	106						integral to membrane					0		all_lung(54;0.00338)|Lung NSC(58;0.0133)|Hepatocellular(245;0.0153)	LUSC - Lung squamous cell carcinoma(45;1.5e-07)															---	---	---	---
ANK1	286	broad.mit.edu	37	8	41753883	41753883	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:41753883C>T	uc003xom.2	-	1	398	c.116G>A	c.(115-117)CGA>CAA	p.R39Q		NM_001142446	NP_001135918	P16157	ANK1_HUMAN	ankyrin 1 isoform 9	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)															---	---	---	---
MYST3	7994	broad.mit.edu	37	8	41792077	41792077	+	Missense_Mutation	SNP	C	T	T	rs139494583		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:41792077C>T	uc010lxb.2	-	18	4205	c.3661G>A	c.(3661-3663)GAG>AAG	p.E1221K	MYST3_uc010lxc.2_Missense_Mutation_p.E1221K|MYST3_uc003xon.3_Missense_Mutation_p.E1221K	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	1221	Glu-rich.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)															---	---	---	---
CHRNB3	1142	broad.mit.edu	37	8	42587259	42587259	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:42587259C>T	uc003xpi.1	+	5	937	c.809C>T	c.(808-810)TCG>TTG	p.S270L		NM_000749	NP_000740	Q05901	ACHB3_HUMAN	cholinergic receptor, nicotinic, beta	270	Helical; (Potential).				synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)	1	all_lung(13;5.7e-12)|Lung NSC(13;1.6e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00026)|Lung NSC(58;0.000992)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	Lung(22;0.0199)|LUSC - Lung squamous cell carcinoma(45;0.0869)															---	---	---	---
PRKDC	5591	broad.mit.edu	37	8	48752574	48752574	+	Intron	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:48752574T>C	uc003xqi.2	-						PRKDC_uc003xqj.2_Intron|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835			protein kinase, DNA-activated, catalytic						cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)											NHEJ					---	---	---	---
PRKDC	5591	broad.mit.edu	37	8	48809861	48809861	+	Intron	SNP	A	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:48809861A>T	uc003xqi.2	-						PRKDC_uc003xqj.2_Intron|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835			protein kinase, DNA-activated, catalytic						cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)											NHEJ					---	---	---	---
NPBWR1	2831	broad.mit.edu	37	8	53852514	53852514	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:53852514G>A	uc011ldu.1	+	1	47	c.47G>A	c.(46-48)GGC>GAC	p.G16D		NM_005285	NP_005276	P48145	NPBW1_HUMAN	G protein-coupled receptor 7	16	Extracellular (Potential).				synaptic transmission	plasma membrane	opioid receptor activity|protein binding			ovary(2)|breast(1)	3		Lung NSC(129;0.0222)|all_epithelial(80;0.0301)|all_lung(136;0.0431)																---	---	---	---
RP1	6101	broad.mit.edu	37	8	55533629	55533629	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:55533629G>A	uc003xsd.1	+	2	251	c.103G>A	c.(103-105)GCC>ACC	p.A35T	RP1_uc011ldy.1_Missense_Mutation_p.A35T	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	35					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)															---	---	---	---
PLAG1	5324	broad.mit.edu	37	8	57080054	57080054	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:57080054G>T	uc003xsq.3	-	3	702	c.251C>A	c.(250-252)GCT>GAT	p.A84D	PLAG1_uc003xsr.3_Missense_Mutation_p.A84D|PLAG1_uc010lyi.2_Missense_Mutation_p.A84D|PLAG1_uc010lyj.2_Missense_Mutation_p.A2D	NM_001114635	NP_001108107	Q6DJT9	PLAG1_HUMAN	pleiomorphic adenoma gene 1 isoform b	84	Interacts with KPNA2.|C2H2-type 2.|Decreased nuclear import with localization in the nucleus but also in the cytoplasm.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding		CTNNB1/PLAG1(60)|FGFR1_ENST00000447712/PLAG1(28)|CHCHD7/PLAG1(12)|LIFR_ENST00000263409/PLAG1(10)|HAS2/PLAG1(10)|COL1A2/PLAG1(3)|TCEA1_ENST00000521604/PLAG1(3)	salivary_gland(113)|soft_tissue(13)|lung(1)|central_nervous_system(1)|breast(1)	129		all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.125)	Epithelial(17;0.00179)|all cancers(17;0.0125)					T	TCEA1|LIFR|CTNNB1|CHCHD7	salivary adenoma								---	---	---	---
CYP7A1	1581	broad.mit.edu	37	8	59404268	59404268	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:59404268T>C	uc003xtm.3	-	6	1344	c.1281A>G	c.(1279-1281)GGA>GGG	p.G427G		NM_000780	NP_000771	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A,	427					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			ovary(1)	1		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)												Neonatal_Giant_Cell_Hepatitis				---	---	---	---
CSPP1	79848	broad.mit.edu	37	8	68062155	68062155	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:68062155G>A	uc003xxi.2	+	18	2234	c.2203G>A	c.(2203-2205)GCA>ACA	p.A735T	CSPP1_uc003xxg.1_Missense_Mutation_p.A727T|CSPP1_uc003xxh.1_RNA|CSPP1_uc003xxj.2_Missense_Mutation_p.A700T|CSPP1_uc003xxk.2_Intron	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1	735						centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)															---	---	---	---
ARFGEF1	10565	broad.mit.edu	37	8	68172074	68172074	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:68172074T>C	uc003xxo.1	-	15	2601	c.2211A>G	c.(2209-2211)TTA>TTG	p.L737L	ARFGEF1_uc003xxl.1_Silent_p.L191L	NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	737	SEC7.				exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)															---	---	---	---
PREX2	80243	broad.mit.edu	37	8	69031758	69031758	+	Intron	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:69031758G>A	uc003xxv.1	+							NM_024870	NP_079146			DEP domain containing 2 isoform a						G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17																		---	---	---	---
NCOA2	10499	broad.mit.edu	37	8	71087086	71087086	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:71087086C>T	uc003xyn.1	-	5	430	c.268G>A	c.(268-270)GCA>ACA	p.A90T		NM_006540	NP_006531	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	90					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)	lung(6)|soft_tissue(4)|breast(2)|skin(2)|ovary(1)|pancreas(1)	16	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)					T	RUNXBP2	AML								---	---	---	---
ZFHX4	79776	broad.mit.edu	37	8	77616635	77616635	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:77616635C>T	uc003yav.2	+	2	699	c.312C>T	c.(310-312)CGC>CGT	p.R104R	ZFHX4_uc003yat.1_Silent_p.R104R|ZFHX4_uc003yau.1_Silent_p.R104R|ZFHX4_uc003yaw.1_Silent_p.R104R	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	104						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)												HNSCC(33;0.089)			---	---	---	---
ZFHX4	79776	broad.mit.edu	37	8	77763270	77763270	+	Silent	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:77763270C>A	uc003yav.2	+	10	4365	c.3978C>A	c.(3976-3978)CCC>CCA	p.P1326P	ZFHX4_uc003yau.1_Silent_p.P1371P|ZFHX4_uc003yaw.1_Silent_p.P1326P	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1326						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)												HNSCC(33;0.089)			---	---	---	---
E2F5	1875	broad.mit.edu	37	8	86121651	86121651	+	Intron	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:86121651T>C	uc003ycz.3	+						E2F5_uc003yda.3_Intron|E2F5_uc010mab.2_Intron|E2F5_uc003ydb.3_Intron	NM_001951	NP_001942			E2F transcription factor 5 isoform 1						G1 phase of mitotic cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(1)	1																		---	---	---	---
TMEM67	91147	broad.mit.edu	37	8	94815919	94815919	+	Intron	SNP	A	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:94815919A>T	uc011lgk.1	+						TMEM67_uc010maw.2_Intron|TMEM67_uc003yga.3_Intron|TMEM67_uc011lgl.1_Intron	NM_153704	NP_714915			meckelin isoform 1						cilium assembly|ER-associated protein catabolic process|negative regulation of centrosome duplication	centrosome|cilium membrane|cytoplasmic vesicle membrane|endoplasmic reticulum membrane|integral to membrane|microtubule basal body	unfolded protein binding			ovary(2)	2	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.00896)															---	---	---	---
GDF6	392255	broad.mit.edu	37	8	97157104	97157104	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:97157104A>G	uc003yhp.2	-	2	1155	c.1055T>C	c.(1054-1056)CTA>CCA	p.L352P		NM_001001557	NP_001001557	Q6KF10	GDF6_HUMAN	growth differentiation factor 6 precursor	352					activin receptor signaling pathway|BMP signaling pathway|growth|pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(1)|breast(1)|pancreas(1)	3	Breast(36;2.67e-05)																	---	---	---	---
KCNS2	3788	broad.mit.edu	37	8	99441238	99441238	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:99441238C>A	uc003yin.2	+	2	1381	c.1031C>A	c.(1030-1032)TCC>TAC	p.S344Y		NM_020697	NP_065748	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel,	344	Helical; Name=Segment S5; (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)															---	---	---	---
STK3	6788	broad.mit.edu	37	8	99468226	99468226	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:99468226C>T	uc003yip.2	-	11	1461	c.1320G>A	c.(1318-1320)TTG>TTA	p.L440L	STK3_uc003yio.2_Silent_p.L468L	NM_006281	NP_006272	Q13188	STK3_HUMAN	serine/threonine kinase 3	440	SARAH.				apoptosis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of apoptosis	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein dimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity			lung(3)|ovary(1)	4	Breast(36;2.4e-06)	Breast(495;0.106)	OV - Ovarian serous cystadenocarcinoma(57;0.0382)	KIRC - Kidney renal clear cell carcinoma(542;9.44e-06)														---	---	---	---
RRM2B	50484	broad.mit.edu	37	8	103237206	103237206	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:103237206C>T	uc003ykn.2	-	4	606	c.362G>A	c.(361-363)CGC>CAC	p.R121H	RRM2B_uc003yko.2_RNA|RRM2B_uc010mbv.1_Missense_Mutation_p.R69H|RRM2B_uc010mbw.1_Intron|RRM2B_uc010mbx.1_Intron|RRM2B_uc010mby.1_Intron	NM_015713	NP_056528	Q7LG56	RIR2B_HUMAN	ribonucleotide reductase M2 B (TP53 inducible)	121			R -> H (in MTDPS8B).		deoxyribonucleoside diphosphate metabolic process|DNA repair|nucleobase, nucleoside and nucleotide interconversion	nucleoplasm	ribonucleoside-diphosphate reductase activity|transition metal ion binding			ovary(2)	2	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000728)										Direct_reversal_of_damage|Modulation_of_nucleotide_pools					---	---	---	---
AZIN1	51582	broad.mit.edu	37	8	103840907	103840907	+	Intron	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:103840907C>A	uc003ykx.2	-						AZIN1_uc003yky.2_Intron	NM_015878	NP_056962			ornithine decarboxylase antizyme inhibitor						polyamine biosynthetic process|regulation of cellular amino acid metabolic process	cytosol	catalytic activity|protein binding				0	Lung NSC(17;0.000143)|all_lung(17;0.000294)		OV - Ovarian serous cystadenocarcinoma(57;0.000196)|STAD - Stomach adenocarcinoma(118;0.0414)															---	---	---	---
SLC25A32	81034	broad.mit.edu	37	8	104415469	104415469	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:104415469G>A	uc003yll.2	-	4	778	c.475C>T	c.(475-477)CCA>TCA	p.P159S	SLC25A32_uc011lhr.1_Missense_Mutation_p.P27S	NM_030780	NP_110407	Q9H2D1	MFTC_HUMAN	solute carrier family 25, member 32	159	Solcar 2.				folic acid metabolic process|mitochondrial transport	integral to membrane|mitochondrial inner membrane	binding|folic acid transporter activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(57;2.79e-06)|STAD - Stomach adenocarcinoma(118;0.197)		Folic Acid(DB00158)													---	---	---	---
RIMS2	9699	broad.mit.edu	37	8	105257232	105257232	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:105257232G>T	uc003yls.2	+	24	3718	c.3477G>T	c.(3475-3477)CAG>CAT	p.Q1159H	RIMS2_uc003ylp.2_Missense_Mutation_p.Q1141H|RIMS2_uc003ylw.2_Missense_Mutation_p.Q1148H|RIMS2_uc003ylq.2_Missense_Mutation_p.Q955H|RIMS2_uc003ylr.2_Missense_Mutation_p.Q980H	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1203					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)												HNSCC(12;0.0054)			---	---	---	---
PKHD1L1	93035	broad.mit.edu	37	8	110510973	110510973	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:110510973G>A	uc003yne.2	+	67	10905	c.10801G>A	c.(10801-10803)GCC>ACC	p.A3601T		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	3601	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)												HNSCC(38;0.096)			---	---	---	---
COLEC10	10584	broad.mit.edu	37	8	120118226	120118226	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:120118226C>T	uc003yoo.2	+	6	727	c.630C>T	c.(628-630)GGC>GGT	p.G210G		NM_006438	NP_006429	Q9Y6Z7	COL10_HUMAN	collectin sub-family member 10 precursor	210	C-type lectin.					collagen|cytoplasm	mannose binding			ovary(2)|skin(1)	3	all_cancers(13;4.13e-26)|Lung NSC(37;1.36e-07)|Ovarian(258;0.018)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00113)															---	---	---	---
SNTB1	6641	broad.mit.edu	37	8	121823609	121823609	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:121823609C>T	uc010mdg.2	-	1	701	c.475G>A	c.(475-477)GCC>ACC	p.A159T	SNTB1_uc003ype.2_Missense_Mutation_p.A159T	NM_021021	NP_066301	Q13884	SNTB1_HUMAN	basic beta 1 syntrophin	159	PH 1.|PDZ.				muscle contraction	cell junction|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|calmodulin binding			skin(5)	5	Lung NSC(37;4.46e-09)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)		STAD - Stomach adenocarcinoma(47;0.00503)															---	---	---	---
ZHX2	22882	broad.mit.edu	37	8	123964440	123964440	+	Silent	SNP	C	T	T	rs142739771		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:123964440C>T	uc003ypk.1	+	3	1257	c.690C>T	c.(688-690)GGC>GGT	p.G230G		NM_014943	NP_055758	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	230	Required for homodimerization.					cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)															---	---	---	---
KIAA0196	9897	broad.mit.edu	37	8	126062904	126062904	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:126062904C>T	uc003yrt.2	-	18	2430	c.2101G>A	c.(2101-2103)GAT>AAT	p.D701N	KIAA0196_uc011lir.1_Missense_Mutation_p.D553N|KIAA0196_uc003yru.1_Missense_Mutation_p.D275N	NM_014846	NP_055661	Q12768	STRUM_HUMAN	strumpellin	701					cell death	WASH complex				ovary(2)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)															---	---	---	---
ADCY8	114	broad.mit.edu	37	8	132052107	132052107	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:132052107C>T	uc003ytd.3	-	1	729	c.473G>A	c.(472-474)CGC>CAC	p.R158H	ADCY8_uc010mds.2_Missense_Mutation_p.R158H	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	158	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)												HNSCC(32;0.087)			---	---	---	---
ZFAT	57623	broad.mit.edu	37	8	135649909	135649909	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:135649909C>T	uc003yup.2	-	3	418	c.243G>A	c.(241-243)ACG>ACA	p.T81T	ZFAT_uc003yun.2_Silent_p.T69T|ZFAT_uc003yuo.2_Silent_p.T69T|ZFAT_uc010meh.2_Silent_p.T69T|ZFAT_uc010mei.2_RNA|ZFAT_uc003yuq.2_Silent_p.T69T|ZFAT_uc010mej.2_Silent_p.T81T|ZFAT_uc003yur.2_Silent_p.T69T	NM_020863	NP_065914	Q9P243	ZFAT_HUMAN	zinc finger protein 406 isoform ZFAT-1	81					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)															---	---	---	---
KCNK9	51305	broad.mit.edu	37	8	140630506	140630506	+	Missense_Mutation	SNP	C	T	T	rs149047706		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:140630506C>T	uc003yvf.1	-	2	1184	c.1120G>A	c.(1120-1122)GTT>ATT	p.V374I	KCNK9_uc003yvg.1_Missense_Mutation_p.V374I|KCNK9_uc003yve.1_RNA	NM_016601	NP_057685	Q9NPC2	KCNK9_HUMAN	potassium channel, subfamily K, member 9	374	Cytoplasmic (Potential).					integral to membrane|membrane fraction	potassium channel activity|voltage-gated ion channel activity			ovary(2)|lung(1)	3	all_cancers(97;3.94e-14)|all_epithelial(106;4.81e-13)|Lung NSC(106;8.18e-05)|all_lung(105;0.00015)|Ovarian(258;0.00235)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;0.134)	BRCA - Breast invasive adenocarcinoma(115;0.0855)															---	---	---	---
KCNK9	51305	broad.mit.edu	37	8	140630715	140630715	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:140630715G>A	uc003yvf.1	-	2	975	c.911C>T	c.(910-912)TCG>TTG	p.S304L	KCNK9_uc003yvg.1_Missense_Mutation_p.S304L|KCNK9_uc003yve.1_RNA	NM_016601	NP_057685	Q9NPC2	KCNK9_HUMAN	potassium channel, subfamily K, member 9	304	Cytoplasmic (Potential).					integral to membrane|membrane fraction	potassium channel activity|voltage-gated ion channel activity			ovary(2)|lung(1)	3	all_cancers(97;3.94e-14)|all_epithelial(106;4.81e-13)|Lung NSC(106;8.18e-05)|all_lung(105;0.00015)|Ovarian(258;0.00235)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;0.134)	BRCA - Breast invasive adenocarcinoma(115;0.0855)															---	---	---	---
PTK2	5747	broad.mit.edu	37	8	141799597	141799597	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:141799597G>A	uc003yvu.2	-	14	1383	c.1153C>T	c.(1153-1155)CGG>TGG	p.R385W	PTK2_uc011ljq.1_Missense_Mutation_p.R46W|PTK2_uc003yvp.2_Missense_Mutation_p.R46W|PTK2_uc003yvq.2_5'UTR|PTK2_uc003yvr.2_Missense_Mutation_p.R284W|PTK2_uc003yvs.2_Missense_Mutation_p.R385W|PTK2_uc003yvt.2_Missense_Mutation_p.R407W|PTK2_uc003yvv.2_Missense_Mutation_p.R272W|PTK2_uc011ljr.1_Missense_Mutation_p.R385W	NM_153831	NP_722560	Q05397	FAK1_HUMAN	PTK2 protein tyrosine kinase 2 isoform a	385					axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)															---	---	---	---
DENND3	22898	broad.mit.edu	37	8	142202554	142202554	+	Intron	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:142202554C>T	uc003yvy.2	+						DENND3_uc010mep.2_Intron|DENND3_uc003ywa.1_Intron|DENND3_uc003ywb.2_Intron	NM_014957	NP_055772			DENN/MADD domain containing 3											ovary(1)	1	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)															---	---	---	---
C8orf73	642475	broad.mit.edu	37	8	144650000	144650000	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:144650000C>T	uc010mff.2	-	12	1867	c.1823G>A	c.(1822-1824)CGG>CAG	p.R608Q		NM_001100878	NP_001094348	A6NGR9	CH073_HUMAN	hypothetical protein LOC642475	608							binding			ovary(1)	1	all_cancers(97;6.49e-11)|all_epithelial(106;4.73e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.014)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.146)															---	---	---	---
TSTA3	7264	broad.mit.edu	37	8	144695077	144695077	+	3'UTR	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:144695077G>A	uc003yza.2	-	11					TSTA3_uc003yzb.2_3'UTR	NM_003313	NP_003304			tissue specific transplantation antigen P35B						'de novo' GDP-L-fucose biosynthetic process|leukocyte cell-cell adhesion		coenzyme binding|electron carrier activity|GDP-4-dehydro-D-rhamnose reductase activity|GDP-L-fucose synthase activity|isomerase activity			pancreas(1)	1	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.17e-38)|Epithelial(56;7.17e-37)|all cancers(56;2.46e-32)|Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)		NADH(DB00157)													---	---	---	---
TSTA3	7264	broad.mit.edu	37	8	144695756	144695756	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:144695756C>T	uc003yza.2	-	9	784	c.748G>A	c.(748-750)GTC>ATC	p.V250I	TSTA3_uc003yzb.2_Missense_Mutation_p.V250I	NM_003313	NP_003304	Q13630	FCL_HUMAN	tissue specific transplantation antigen P35B	250					'de novo' GDP-L-fucose biosynthetic process|leukocyte cell-cell adhesion		coenzyme binding|electron carrier activity|GDP-4-dehydro-D-rhamnose reductase activity|GDP-L-fucose synthase activity|isomerase activity			pancreas(1)	1	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.17e-38)|Epithelial(56;7.17e-37)|all cancers(56;2.46e-32)|Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)		NADH(DB00157)													---	---	---	---
TSTA3	7264	broad.mit.edu	37	8	144697076	144697076	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:144697076C>T	uc003yza.2	-	4	307	c.271G>A	c.(271-273)GTG>ATG	p.V91M	TSTA3_uc003yzb.2_Missense_Mutation_p.V91M|TSTA3_uc011lko.1_Missense_Mutation_p.V91M	NM_003313	NP_003304	Q13630	FCL_HUMAN	tissue specific transplantation antigen P35B	91					'de novo' GDP-L-fucose biosynthetic process|leukocyte cell-cell adhesion		coenzyme binding|electron carrier activity|GDP-4-dehydro-D-rhamnose reductase activity|GDP-L-fucose synthase activity|isomerase activity			pancreas(1)	1	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.17e-38)|Epithelial(56;7.17e-37)|all cancers(56;2.46e-32)|Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)		NADH(DB00157)													---	---	---	---
NRBP2	340371	broad.mit.edu	37	8	144920885	144920885	+	Silent	SNP	G	A	A	rs140645302	byFrequency	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:144920885G>A	uc011lkt.1	-	10	947	c.807C>T	c.(805-807)CGC>CGT	p.R269R	NRBP2_uc003yzv.2_Silent_p.R26R|NRBP2_uc003yzz.1_5'Flank|NRBP2_uc003yzw.2_5'Flank|NRBP2_uc010mfl.2_5'Flank|NRBP2_uc010mfm.2_Silent_p.R26R|NRBP2_uc011lks.1_Silent_p.R26R|NRBP2_uc003yzy.2_Silent_p.R26R	NM_178564	NP_848659	Q9NSY0	NRBP2_HUMAN	nuclear receptor binding protein 2	269	Protein kinase.				negative regulation of neuron apoptosis|neuron differentiation	cytoplasm	ATP binding|protein kinase activity	p.R275R(1)		central_nervous_system(2)	2	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)															---	---	---	---
PLEC	5339	broad.mit.edu	37	8	144992113	144992113	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:144992113C>T	uc003zaf.1	-	32	12457	c.12287G>A	c.(12286-12288)CGC>CAC	p.R4096H	PLEC_uc003zab.1_Missense_Mutation_p.R3959H|PLEC_uc003zac.1_Missense_Mutation_p.R3963H|PLEC_uc003zad.2_Missense_Mutation_p.R3959H|PLEC_uc003zae.1_Missense_Mutation_p.R3927H|PLEC_uc003zag.1_Missense_Mutation_p.R3937H|PLEC_uc003zah.2_Missense_Mutation_p.R3945H|PLEC_uc003zaj.2_Missense_Mutation_p.R3986H	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	4096	Plectin 22.|Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9																		---	---	---	---
PLEC	5339	broad.mit.edu	37	8	144997254	144997254	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:144997254C>T	uc003zaf.1	-	31	7424	c.7254G>A	c.(7252-7254)GCG>GCA	p.A2418A	PLEC_uc003zab.1_Silent_p.A2281A|PLEC_uc003zac.1_Silent_p.A2285A|PLEC_uc003zad.2_Silent_p.A2281A|PLEC_uc003zae.1_Silent_p.A2249A|PLEC_uc003zag.1_Silent_p.A2259A|PLEC_uc003zah.2_Silent_p.A2267A|PLEC_uc003zaj.2_Silent_p.A2308A	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2418	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9																		---	---	---	---
PARP10	84875	broad.mit.edu	37	8	145052082	145052082	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145052082G>A	uc003zal.3	-	10	2832	c.2724C>T	c.(2722-2724)GGC>GGT	p.G908G	PLEC_uc003zaj.2_5'Flank|PARP10_uc003zak.3_Silent_p.G605G|PARP10_uc011lku.1_Silent_p.G920G|PARP10_uc011lkv.1_RNA|PARP10_uc003zam.2_Silent_p.G899G	NM_032789	NP_116178	Q53GL7	PAR10_HUMAN	poly (ADP-ribose) polymerase family, member 10	908	PARP catalytic.					Golgi apparatus|nucleolus	NAD+ ADP-ribosyltransferase activity|nucleotide binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)|pancreas(1)	6	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)															---	---	---	---
HEATR7A	727957	broad.mit.edu	37	8	145235115	145235115	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145235115G>A	uc003zbk.3	+	6	572	c.335G>A	c.(334-336)GGC>GAC	p.G112D	HEATR7A_uc003zbg.2_Missense_Mutation_p.G112D|HEATR7A_uc003zbh.3_Missense_Mutation_p.G112D|HEATR7A_uc003zbi.3_Missense_Mutation_p.G112D|HEATR7A_uc011lla.1_Missense_Mutation_p.G112D|HEATR7A_uc010mft.2_Missense_Mutation_p.G112D	NM_032450	NP_115826	Q8NDA8	HTR7A_HUMAN	HEAT repeat containing 7A isoform 1	112							binding				0																		---	---	---	---
NFKBIL2	4796	broad.mit.edu	37	8	145660224	145660224	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145660224A>G	uc011llg.1	-	20	3070	c.3055T>C	c.(3055-3057)TAC>CAC	p.Y1019H	uc011llh.1_5'Flank	NM_013432	NP_038460	Q96HA7	TONSL_HUMAN	NF-kappa-B inhibitor-like protein 2	1019					cytoplasmic sequestering of transcription factor|double-strand break repair via homologous recombination|replication fork processing	cytoplasm|nuclear replication fork	histone binding|transcription corepressor activity				0	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)															---	---	---	---
ZNF251	90987	broad.mit.edu	37	8	145948631	145948631	+	Silent	SNP	G	A	A	rs35964302		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145948631G>A	uc003zdv.3	-	5	670	c.414C>T	c.(412-414)GGC>GGT	p.G138G		NM_138367	NP_612376	Q9BRH9	ZN251_HUMAN	zinc finger protein 251	138					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;7.54e-38)|all cancers(56;6.19e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.198)														---	---	---	---
CBWD1	55871	broad.mit.edu	37	9	164038	164038	+	Splice_Site	SNP	C	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:164038C>G	uc003zga.3	-	5	537	c.431_splice	c.e5-1	p.G144_splice	CBWD1_uc010mgs.2_Splice_Site|CBWD1_uc003zgb.3_Splice_Site_p.G108_splice|CBWD1_uc003zgc.3_Splice_Site_p.G144_splice|CBWD1_uc011llr.1_Splice_Site_p.G108_splice	NM_018491	NP_060961			COBW domain containing 1 isoform 1								ATP binding|protein binding			ovary(1)	1	all_lung(41;0.218)	all_cancers(5;3.04e-16)|all_epithelial(5;4.68e-12)|all_lung(10;1.94e-10)|Lung NSC(10;3.61e-10)|Acute lymphoblastic leukemia(5;0.00439)|Breast(48;0.0148)|all_hematologic(5;0.024)|Prostate(43;0.122)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)														---	---	---	---
DOCK8	81704	broad.mit.edu	37	9	312043	312043	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:312043T>C	uc003zgf.2	+	6	730	c.618T>C	c.(616-618)CCT>CCC	p.P206P	DOCK8_uc011lls.1_Silent_p.P206P|DOCK8_uc010mgu.2_5'UTR|DOCK8_uc010mgv.2_Silent_p.P138P|DOCK8_uc010mgt.2_Silent_p.P138P|DOCK8_uc003zgg.2_Silent_p.P138P|DOCK8_uc003zgh.2_RNA	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	206					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)														---	---	---	---
DMRT1	1761	broad.mit.edu	37	9	841907	841907	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:841907G>A	uc003zgv.2	+	1	218	c.69G>A	c.(67-69)CCG>CCA	p.P23P	DMRT1_uc003zgu.1_Silent_p.P23P	NM_021951	NP_068770	Q9Y5R6	DMRT1_HUMAN	doublesex and mab-3 related transcription factor	23					cell differentiation|male gonad development|sex determination	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		all_lung(10;2.66e-10)|Lung NSC(10;2.82e-10)|Breast(48;0.232)		Lung(218;0.037)														---	---	---	---
KIAA1797	54914	broad.mit.edu	37	9	20862680	20862680	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:20862680C>A	uc003zog.1	+	18	2387	c.2024C>A	c.(2023-2025)CCT>CAT	p.P675H	KIAA1797_uc003zoh.1_Missense_Mutation_p.P111H	NM_017794	NP_060264	Q5VW36	K1797_HUMAN	hypothetical protein LOC54914	675						integral to membrane	binding			ovary(8)|breast(1)|kidney(1)	10				GBM - Glioblastoma multiforme(3;2.1e-125)|Lung(42;2.76e-14)|LUSC - Lung squamous cell carcinoma(42;1.99e-11)														---	---	---	---
C9orf72	203228	broad.mit.edu	37	9	27556644	27556644	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:27556644G>C	uc003zqq.2	-	8	1103	c.1006C>G	c.(1006-1008)CTG>GTG	p.L336V		NM_018325	NP_060795	Q96LT7	CI072_HUMAN	hypothetical protein LOC203228 isoform a	336										ovary(3)|central_nervous_system(1)	4		all_neural(11;7.57e-10)		LUSC - Lung squamous cell carcinoma(38;0.0001)|Lung(218;0.00016)														---	---	---	---
RUSC2	9853	broad.mit.edu	37	9	35558263	35558263	+	Missense_Mutation	SNP	G	A	A	rs147279845	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:35558263G>A	uc003zww.2	+	7	3385	c.3130G>A	c.(3130-3132)GTC>ATC	p.V1044I	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Missense_Mutation_p.V1044I	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	1044	RUN.					cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)															---	---	---	---
SPAG8	26206	broad.mit.edu	37	9	35811534	35811534	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:35811534C>T	uc003zye.2	-	2	624	c.509G>A	c.(508-510)GGC>GAC	p.G170D	SPAG8_uc003zyf.2_Missense_Mutation_p.G87D|SPAG8_uc003zyg.2_Missense_Mutation_p.G170D	NM_172312	NP_758516	Q99932	SPAG8_HUMAN	sperm associated antigen 8 isoform 2	170	Gly-rich.					acrosomal vesicle|membrane				ovary(1)	1	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)															---	---	---	---
PGM5	5239	broad.mit.edu	37	9	70993145	70993145	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:70993145A>G	uc004agr.2	+	2	521	c.292A>G	c.(292-294)ATC>GTC	p.I98V		NM_021965	NP_068800	Q15124	PGM5_HUMAN	phosphoglucomutase 5	98					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			ovary(1)|pancreas(1)	2																		---	---	---	---
APBA1	320	broad.mit.edu	37	9	72047539	72047539	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:72047539C>T	uc004ahh.2	-	12	2631	c.2355G>A	c.(2353-2355)GGG>GGA	p.G785G		NM_001163	NP_001154	Q02410	APBA1_HUMAN	amyloid beta A4 precursor protein-binding,	785	PDZ 2.				axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				lung(1)	1																		---	---	---	---
KIF27	55582	broad.mit.edu	37	9	86465140	86465140	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:86465140G>A	uc004ana.2	-	16	3574	c.3430C>T	c.(3430-3432)CGG>TGG	p.R1144W	KIF27_uc010mpw.2_Missense_Mutation_p.R1078W|KIF27_uc010mpx.2_Missense_Mutation_p.R1047W	NM_017576	NP_060046	Q86VH2	KIF27_HUMAN	kinesin family member 27	1144	Potential.				cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			lung(4)|skin(1)	5																		---	---	---	---
KIF27	55582	broad.mit.edu	37	9	86482717	86482717	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:86482717C>T	uc004ana.2	-	13	2960	c.2816G>A	c.(2815-2817)CGC>CAC	p.R939H	KIF27_uc010mpw.2_Missense_Mutation_p.R873H|KIF27_uc010mpx.2_Intron	NM_017576	NP_060046	Q86VH2	KIF27_HUMAN	kinesin family member 27	939	Potential.				cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			lung(4)|skin(1)	5																		---	---	---	---
HNRNPK	3190	broad.mit.edu	37	9	86585818	86585818	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:86585818C>T	uc004ang.3	-	14	1326	c.1102G>A	c.(1102-1104)GGA>AGA	p.G368R	HNRNPK_uc011lsw.1_Missense_Mutation_p.G128R|HNRNPK_uc004and.3_Missense_Mutation_p.G128R|HNRNPK_uc004ank.3_Intron|HNRNPK_uc004anf.3_Missense_Mutation_p.G368R|HNRNPK_uc004anh.3_Missense_Mutation_p.G344R|HNRNPK_uc011lsx.1_Missense_Mutation_p.G344R|HNRNPK_uc004ani.3_Intron|HNRNPK_uc004anj.3_Intron|HNRNPK_uc004ann.3_Intron|HNRNPK_uc004anl.3_Missense_Mutation_p.G368R|HNRNPK_uc004anm.3_Missense_Mutation_p.G368R|uc004ano.1_5'Flank|MIR7-1_hsa-mir-7-1|MI0000263_5'Flank	NM_031262	NP_112552	P61978	HNRPK_HUMAN	heterogeneous nuclear ribonucleoprotein K	368	5 X 4 AA repeats of G-X-G-G.|2 X 22 AA approximate repeats.				interspecies interaction between organisms|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of receptor-mediated endocytosis|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of low-density lipoprotein particle clearance|signal transduction	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nuclear chromatin|nucleoplasm	protein binding|RNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|single-stranded DNA binding			skin(1)	1																		---	---	---	---
NFIL3	4783	broad.mit.edu	37	9	94171958	94171958	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:94171958T>C	uc004arh.2	-	2	1454	c.1059A>G	c.(1057-1059)TCA>TCG	p.S353S		NM_005384	NP_005375	Q16649	NFIL3_HUMAN	nuclear factor, interleukin 3 regulated	353	Necessary for transcriptional repression and sufficient for interaction with DR1.				circadian rhythm|immune response|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0																		---	---	---	---
ASPN	54829	broad.mit.edu	37	9	95237178	95237178	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:95237178A>G	uc004ase.1	-	2	246	c.2T>C	c.(1-3)ATG>ACG	p.M1T	CENPP_uc004arz.2_Intron|CENPP_uc010mqx.2_Intron|ASPN_uc010mqy.1_Missense_Mutation_p.M1T	NM_017680	NP_060150	Q9BXN1	ASPN_HUMAN	asporin precursor	1					bone mineralization|negative regulation of tooth mineralization|negative regulation of transforming growth factor beta receptor signaling pathway	proteinaceous extracellular matrix	calcium ion binding				0																		---	---	---	---
BICD2	23299	broad.mit.edu	37	9	95482892	95482892	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:95482892C>T	uc004aso.1	-	4	809	c.752G>A	c.(751-753)CGC>CAC	p.R251H	BICD2_uc004asp.1_Missense_Mutation_p.R251H	NM_015250	NP_056065	Q8TD16	BICD2_HUMAN	bicaudal D homolog 2 isoform 2	251	Potential.				microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule	cytoplasmic vesicle|cytoskeleton|Golgi apparatus|plasma membrane	Rab GTPase binding			skin(1)	1																		---	---	---	---
WNK2	65268	broad.mit.edu	37	9	96080171	96080171	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:96080171C>T	uc004ati.1	+	30	6756	c.6756C>T	c.(6754-6756)ACC>ACT	p.T2252T	WNK2_uc011lud.1_Intron|WNK2_uc004atj.2_Intron|WNK2_uc004atk.2_3'UTR	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	2252					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|stomach(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)|breast(1)	12																		---	---	---	---
PTCH1	5727	broad.mit.edu	37	9	98229700	98229700	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:98229700A>G	uc004avk.3	-	15	2446	c.2258T>C	c.(2257-2259)GTG>GCG	p.V753A	PTCH1_uc010mro.2_Missense_Mutation_p.V602A|PTCH1_uc010mrp.2_Missense_Mutation_p.V602A|PTCH1_uc010mrq.2_Missense_Mutation_p.V602A|PTCH1_uc004avl.3_Missense_Mutation_p.V602A|PTCH1_uc010mrr.2_Missense_Mutation_p.V687A|PTCH1_uc004avm.3_Missense_Mutation_p.V752A	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	753	Helical; (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)												Basal_Cell_Nevus_syndrome				---	---	---	---
NCBP1	4686	broad.mit.edu	37	9	100405604	100405604	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:100405604T>A	uc004axq.2	+	4	802	c.343T>A	c.(343-345)TCA>ACA	p.S115T		NM_002486	NP_002477	Q09161	NCBP1_HUMAN	nuclear cap binding protein subunit 1, 80kDa	115	MIF4G.				gene silencing by RNA|histone mRNA metabolic process|mRNA 3'-end processing|mRNA capping|mRNA cleavage|mRNA export from nucleus|ncRNA metabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of mRNA 3'-end processing|positive regulation of viral transcription|regulation of translational initiation|spliceosomal snRNP assembly|termination of RNA polymerase II transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytosol|mRNA cap binding complex|nucleoplasm|ribonucleoprotein complex	protein binding|RNA cap binding			central_nervous_system(1)	1		Acute lymphoblastic leukemia(62;0.158)																---	---	---	---
RGS3	5998	broad.mit.edu	37	9	116269742	116269742	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:116269742C>T	uc004bhq.2	+	14	1470	c.1261C>T	c.(1261-1263)CGC>TGC	p.R421C	RGS3_uc004bhr.2_Missense_Mutation_p.R309C|RGS3_uc004bhs.2_Missense_Mutation_p.R311C|RGS3_uc004bht.2_Missense_Mutation_p.R140C|RGS3_uc010muy.2_Missense_Mutation_p.R140C|RGS3_uc004bhu.2_Missense_Mutation_p.R47C	NM_144488	NP_652759	P49796	RGS3_HUMAN	regulator of G-protein signalling 3 isoform 6	421					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3																		---	---	---	---
Unknown	0	broad.mit.edu	37	9	117072987	117072987	+	IGR	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:117072987G>A								COL27A1 (13 upstream) : ORM1 (12316 downstream)																																			---	---	---	---
DFNB31	25861	broad.mit.edu	37	9	117165219	117165219	+	Intron	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:117165219G>A	uc004biz.3	-						DFNB31_uc004bix.2_Intron|DFNB31_uc004biy.3_Intron|DFNB31_uc004bja.3_Intron	NM_015404	NP_056219			CASK-interacting protein CIP98 isoform 1						inner ear receptor stereocilium organization|retina homeostasis|sensory perception of light stimulus|sensory perception of sound	cytoplasm|growth cone|stereocilium				ovary(4)|central_nervous_system(1)|pancreas(1)	6																		---	---	---	---
TNC	3371	broad.mit.edu	37	9	117848975	117848975	+	Silent	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:117848975G>T	uc004bjj.3	-	3	1397	c.1035C>A	c.(1033-1035)ACC>ACA	p.T345T	TNC_uc010mvf.2_Silent_p.T345T	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	345	EGF-like 7.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7																		---	---	---	---
CEP110	11064	broad.mit.edu	37	9	123898189	123898189	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:123898189C>T	uc004bkx.1	+	13	2162	c.2131C>T	c.(2131-2133)CGG>TGG	p.R711W	CEP110_uc004bky.1_Missense_Mutation_p.R315W|CEP110_uc004bkz.1_Missense_Mutation_p.R159W|CEP110_uc004bla.1_Missense_Mutation_p.R159W	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	centrosomal protein 110kDa	711	Potential.				cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0																		---	---	---	---
RC3H2	54542	broad.mit.edu	37	9	125643021	125643021	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:125643021C>T	uc010mwc.1	-	6	1053	c.812G>A	c.(811-813)CGG>CAG	p.R271Q	RC3H2_uc004bnc.2_RNA|RC3H2_uc004bnd.1_Missense_Mutation_p.R271Q|RC3H2_uc004bne.3_Missense_Mutation_p.R271Q|RC3H2_uc011lzf.1_Missense_Mutation_p.R8Q|RC3H2_uc011lzg.1_Missense_Mutation_p.R271Q|SNORD90_uc004bnf.1_5'Flank	NM_001100588	NP_001094058	Q9HBD1	RC3H2_HUMAN	ring finger and CCCH-type zinc finger domains 2	271						cell surface|endomembrane system|membrane|membrane fraction|perinuclear region of cytoplasm	DNA binding|zinc ion binding			ovary(2)|lung(2)	4																		---	---	---	---
WDR38	401551	broad.mit.edu	37	9	127616484	127616484	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:127616484G>C	uc004box.2	+	2	126	c.70G>C	c.(70-72)GTC>CTC	p.V24L	WDR38_uc011lzn.1_Intron|WDR38_uc011lzo.1_Missense_Mutation_p.V24L|WDR38_uc011lzp.1_5'UTR	NM_001045476	NP_001038941	Q5JTN6	WDR38_HUMAN	WD repeat domain 38	24	WD 1.										0																		---	---	---	---
LMX1B	4010	broad.mit.edu	37	9	129453292	129453292	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:129453292C>T	uc004bqj.2	+	3	485	c.435C>T	c.(433-435)GAC>GAT	p.D145D	LMX1B_uc004bqi.2_Silent_p.D145D|LMX1B_uc011maa.1_Silent_p.D145D	NM_002316	NP_002307	O60663	LMX1B_HUMAN	LIM homeobox transcription factor 1, beta	145	LIM zinc-binding 2.				dorsal/ventral pattern formation|in utero embryonic development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0														Nail-Patella_Syndrome				---	---	---	---
SLC25A25	114789	broad.mit.edu	37	9	130864731	130864731	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:130864731G>A	uc004bte.2	+	4	486	c.457G>A	c.(457-459)GAG>AAG	p.E153K	SLC25A25_uc004btb.2_Missense_Mutation_p.E187K|SLC25A25_uc004btc.2_Missense_Mutation_p.E173K|SLC25A25_uc004btd.2_Missense_Mutation_p.E185K|SLC25A25_uc004btf.2_Missense_Mutation_p.E50K	NM_052901	NP_443133	Q6KCM7	SCMC2_HUMAN	solute carrier family 25, member 25 isoform a	153	Mitochondrial intermembrane (Potential).				transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding				0																		---	---	---	---
SPTAN1	6709	broad.mit.edu	37	9	131356530	131356530	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131356530C>T	uc004bvl.3	+	24	3405	c.3292C>T	c.(3292-3294)CGT>TGT	p.R1098C	SPTAN1_uc011mbg.1_Missense_Mutation_p.R1078C|SPTAN1_uc011mbh.1_Missense_Mutation_p.R1110C|SPTAN1_uc004bvm.3_Missense_Mutation_p.R1098C|SPTAN1_uc004bvn.3_Missense_Mutation_p.R1078C	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1098	Spectrin 12.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10																		---	---	---	---
PKN3	29941	broad.mit.edu	37	9	131482711	131482711	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131482711G>T	uc004bvw.2	+	22	2889	c.2496G>T	c.(2494-2496)CAG>CAT	p.Q832H	PKN3_uc010myh.2_Missense_Mutation_p.A818S|PKN3_uc011mbk.1_Missense_Mutation_p.Q382H	NM_013355	NP_037487	Q6P5Z2	PKN3_HUMAN	protein kinase PKNbeta	832	AGC-kinase C-terminal.				signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein binding|protein kinase C activity			stomach(2)|lung(2)	4																		---	---	---	---
NUP188	23511	broad.mit.edu	37	9	131755979	131755979	+	Intron	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131755979T>C	uc004bws.1	+						NUP188_uc004bwu.2_Intron	NM_015354	NP_056169			nucleoporin 188kDa						carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7																		---	---	---	---
GPR107	57720	broad.mit.edu	37	9	132863396	132863396	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:132863396C>T	uc004bze.2	+	12	1252	c.1025C>T	c.(1024-1026)GCG>GTG	p.A342V	GPR107_uc004bzb.2_Missense_Mutation_p.A153V|GPR107_uc004bzc.3_RNA|GPR107_uc011mbx.1_Missense_Mutation_p.A342V|GPR107_uc004bzd.2_Missense_Mutation_p.A342V	NM_001136557	NP_001130029	Q5VW38	GP107_HUMAN	G protein-coupled receptor 107 isoform 1	342	Helical; Name=3; (Potential).					integral to membrane				upper_aerodigestive_tract(1)	1		Ovarian(14;0.000531)																---	---	---	---
FUBP3	8939	broad.mit.edu	37	9	133488372	133488372	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:133488372C>T	uc004bzr.1	+	5	412	c.304C>T	c.(304-306)CGG>TGG	p.R102W	FUBP3_uc010mzd.1_Missense_Mutation_p.R42W|FUBP3_uc004bzs.1_Missense_Mutation_p.R15W	NM_003934	NP_003925	Q96I24	FUBP3_HUMAN	far upstream element (FUSE) binding protein 3	102	KH 1.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|RNA binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(145;0.000279)														---	---	---	---
FIBCD1	84929	broad.mit.edu	37	9	133779540	133779540	+	Missense_Mutation	SNP	C	T	T	rs147030133	byFrequency	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:133779540C>T	uc004bzz.2	-	7	1542	c.1297G>A	c.(1297-1299)GAC>AAC	p.D433N	FIBCD1_uc011mcc.1_Missense_Mutation_p.D433N	NM_032843	NP_116232	Q8N539	FBCD1_HUMAN	fibrinogen C domain containing 1	433	Fibrinogen C-terminal.|Extracellular (Potential).				signal transduction	extracellular space|integral to membrane	chitin binding|metal ion binding|receptor binding				0	all_hematologic(7;0.0028)			OV - Ovarian serous cystadenocarcinoma(145;3.52e-05)|Epithelial(140;0.00019)														---	---	---	---
NUP214	8021	broad.mit.edu	37	9	134072678	134072678	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:134072678A>G	uc004cag.2	+	29	3908	c.3797A>G	c.(3796-3798)GAG>GGG	p.E1266G	NUP214_uc004cah.2_Missense_Mutation_p.E1256G|NUP214_uc004cai.2_Missense_Mutation_p.E696G|NUP214_uc010mzg.2_RNA|NUP214_uc011mcg.1_Missense_Mutation_p.E92G|NUP214_uc011mcf.1_Missense_Mutation_p.E43G|NUP214_uc010mzh.1_5'UTR|NUP214_uc010mzi.1_5'UTR	NM_005085	NP_005076	P35658	NU214_HUMAN	nucleoporin 214kDa	1266	Pro/Ser/Thr-rich.|11 X 5 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			breast(7)|lung(3)|skin(3)|ovary(2)|central_nervous_system(1)	16	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)				T	DEK|SET|ABL1	AML|T-ALL								---	---	---	---
PPAPDC3	84814	broad.mit.edu	37	9	134183576	134183576	+	Missense_Mutation	SNP	G	A	A	rs146890476		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:134183576G>A	uc004cal.2	+	2	1022	c.718G>A	c.(718-720)GTC>ATC	p.V240I		NM_032728	NP_116117	Q8NBV4	PPAC3_HUMAN	phosphatidic acid phosphatase type 2 domain	240	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear envelope	hydrolase activity			breast(1)	1	all_hematologic(7;0.0119)			OV - Ovarian serous cystadenocarcinoma(145;1.22e-05)|Epithelial(140;0.000173)														---	---	---	---
BAT2L1	84726	broad.mit.edu	37	9	134346320	134346320	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:134346320C>T	uc004can.3	+	13	2112	c.2057C>T	c.(2056-2058)ACG>ATG	p.T686M	BAT2L1_uc010mzj.1_Missense_Mutation_p.T269M|BAT2L1_uc004cao.3_Missense_Mutation_p.T44M	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	686							protein binding				0																		---	---	---	---
POMT1	10585	broad.mit.edu	37	9	134385313	134385313	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:134385313C>T	uc004cav.2	+	8	831	c.629C>T	c.(628-630)ACG>ATG	p.T210M	POMT1_uc011mci.1_3'UTR|POMT1_uc004cax.2_Missense_Mutation_p.T210M|POMT1_uc011mcj.1_Intron|POMT1_uc004cau.2_Missense_Mutation_p.T210M|POMT1_uc004caw.2_Missense_Mutation_p.T156M|POMT1_uc011mck.1_Missense_Mutation_p.T93M|POMT1_uc011mcl.1_Missense_Mutation_p.T58M|POMT1_uc011mcm.1_Missense_Mutation_p.T180M|POMT1_uc011mcn.1_Translation_Start_Site	NM_007171	NP_009102	Q9Y6A1	POMT1_HUMAN	protein-O-mannosyltransferase 1 isoform a	210	Helical; (Potential).				multicellular organismal development|protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			upper_aerodigestive_tract(1)	1		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.65e-05)|Epithelial(140;0.000259)														---	---	---	---
NTNG2	84628	broad.mit.edu	37	9	135073412	135073412	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:135073412G>A	uc004cbh.2	+	3	1049	c.273G>A	c.(271-273)CCG>CCA	p.P91P		NM_032536	NP_115925	Q96CW9	NTNG2_HUMAN	netrin G2 precursor	91	Laminin N-terminal.				axonogenesis	anchored to plasma membrane					0				OV - Ovarian serous cystadenocarcinoma(145;1.23e-05)|Epithelial(140;0.000173)														---	---	---	---
NTNG2	84628	broad.mit.edu	37	9	135073809	135073809	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:135073809G>A	uc004cbh.2	+	3	1446	c.670G>A	c.(670-672)GGC>AGC	p.G224S		NM_032536	NP_115925	Q96CW9	NTNG2_HUMAN	netrin G2 precursor	224	Laminin N-terminal.				axonogenesis	anchored to plasma membrane					0				OV - Ovarian serous cystadenocarcinoma(145;1.23e-05)|Epithelial(140;0.000173)														---	---	---	---
DDX31	64794	broad.mit.edu	37	9	135487583	135487583	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:135487583G>A	uc004cbq.1	-	19	2352	c.2200C>T	c.(2200-2202)CAC>TAC	p.H734Y	DDX31_uc010mzu.1_Missense_Mutation_p.H661Y	NM_022779	NP_073616	Q9H8H2	DDX31_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 31	734						nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(145;2.67e-06)|Epithelial(140;7.61e-05)														---	---	---	---
RALGDS	5900	broad.mit.edu	37	9	135976954	135976954	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:135976954G>A	uc004cco.2	-	16	2427	c.2407C>T	c.(2407-2409)CGC>TGC	p.R803C	RALGDS_uc004cct.1_5'Flank|RALGDS_uc004ccn.2_5'UTR|RALGDS_uc004ccp.2_RNA|RALGDS_uc004ccq.2_Missense_Mutation_p.R791C|RALGDS_uc004ccr.2_Missense_Mutation_p.R802C|RALGDS_uc011mcv.1_Missense_Mutation_p.R774C|RALGDS_uc004ccs.2_Missense_Mutation_p.R748C|RALGDS_uc011mcw.1_Missense_Mutation_p.R874C|RALGDS_uc004ccv.1_Missense_Mutation_p.P630L|RALGDS_uc004ccu.1_Missense_Mutation_p.R572C	NM_006266	NP_006257	Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	803	Ras-associating.				nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			large_intestine(1)|lung(1)|ovary(1)	3				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)				T	CIITA	PMBL|Hodgkin Lymphona|								---	---	---	---
COL5A1	1289	broad.mit.edu	37	9	137703454	137703454	+	Intron	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:137703454G>A	uc004cfe.2	+							NM_000093	NP_000084			alpha 1 type V collagen preproprotein						axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)												OREG0019605	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
KCNT1	57582	broad.mit.edu	37	9	138642852	138642852	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:138642852C>T	uc011mdq.1	+	4	473	c.399C>T	c.(397-399)CGC>CGT	p.R133R	KCNT1_uc011mdr.1_Intron|KCNT1_uc010nbf.2_Silent_p.R85R|KCNT1_uc004cgo.1_5'Flank	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	133						membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)														---	---	---	---
KCNT1	57582	broad.mit.edu	37	9	138670649	138670649	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:138670649A>G	uc011mdq.1	+	23	2784	c.2710A>G	c.(2710-2712)AAC>GAC	p.N904D	KCNT1_uc011mdr.1_Missense_Mutation_p.N731D|KCNT1_uc010nbf.2_Missense_Mutation_p.N859D|KCNT1_uc004cgo.1_Missense_Mutation_p.N653D	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	904						membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)														---	---	---	---
NOTCH1	4851	broad.mit.edu	37	9	139390651	139390651	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139390651G>T	uc004chz.2	-	34	7540	c.7540C>A	c.(7540-7542)CCT>ACT	p.P2514T		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	2514	Cytoplasmic (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity	p.T2512fs*1(1)|p.S2514fs*4(1)|p.S2514F(1)		haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)				T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			---	---	---	---
C9orf172	389813	broad.mit.edu	37	9	139739734	139739734	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139739734T>G	uc011meh.1	+	1	868	c.868T>G	c.(868-870)TTC>GTC	p.F290V	PHPT1_uc004cjp.2_5'Flank	NM_001080482	NP_001073951	C9J069	CI172_HUMAN	chromosome 9 open reading frame 172	290	Pro-rich.										0																		---	---	---	---
ENTPD2	954	broad.mit.edu	37	9	139946009	139946009	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139946009C>T	uc004ckw.1	-	3	395	c.339G>A	c.(337-339)GCG>GCA	p.A113A	ENTPD2_uc004ckv.1_5'Flank|ENTPD2_uc004ckx.1_Silent_p.A113A	NM_203468	NP_982293	Q9Y5L3	ENTP2_HUMAN	ectonucleoside triphosphate diphosphohydrolase 2	113	Extracellular (Potential).					integral to membrane	ATP binding				0	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)														---	---	---	---
DPP7	29952	broad.mit.edu	37	9	140005168	140005168	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:140005168C>T	uc004clh.2	-	13	1441	c.1411G>A	c.(1411-1413)GAG>AAG	p.E471K		NM_013379	NP_037511	Q9UHL4	DPP2_HUMAN	dipeptidyl peptidase 7 preproprotein	471						cytoplasmic membrane-bounded vesicle|extracellular region|lysosome	aminopeptidase activity|protein binding|serine-type peptidase activity				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;4.25e-05)|Epithelial(140;0.000633)														---	---	---	---
PFKP	5214	broad.mit.edu	37	10	3143641	3143641	+	Missense_Mutation	SNP	C	T	T	rs140887616	byFrequency	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:3143641C>T	uc001igp.2	+	4	385	c.349C>T	c.(349-351)CGC>TGC	p.R117C	PFKP_uc001igq.2_Nonsense_Mutation_p.R109*|PFKP_uc009xhr.2_Nonsense_Mutation_p.R79*	NM_002627	NP_002618	Q01813	K6PP_HUMAN	phosphofructokinase, platelet	117					glycolysis	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|metal ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3				GBM - Glioblastoma multiforme(1;0.000975)|all cancers(11;0.00351)|Epithelial(11;0.142)														---	---	---	---
PITRM1	10531	broad.mit.edu	37	10	3193501	3193501	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:3193501G>A	uc010qah.1	-	14	1612	c.1580C>T	c.(1579-1581)GCG>GTG	p.A527V	PITRM1_uc001igr.1_Missense_Mutation_p.A559V|PITRM1_uc001igt.1_Missense_Mutation_p.A559V|PITRM1_uc009xhv.1_Missense_Mutation_p.A124V|PITRM1_uc001igu.1_Missense_Mutation_p.A551V|PITRM1_uc010qai.1_Missense_Mutation_p.A530V|PITRM1_uc001igw.1_Missense_Mutation_p.A559V			E7ES23	E7ES23_HUMAN	SubName: Full=cDNA FLJ54065, moderately similar to Mus musculus pitrilysin metallepetidase 1 (Pitrm1), mRNA;	527					proteolysis		metalloendopeptidase activity|zinc ion binding			pancreas(1)	1																		---	---	---	---
ITIH5	80760	broad.mit.edu	37	10	7621950	7621950	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:7621950G>A	uc001ijq.2	-	9	1265	c.1186C>T	c.(1186-1188)CGG>TGG	p.R396W	ITIH5_uc001ijp.2_Missense_Mutation_p.R182W|ITIH5_uc001ijr.1_Missense_Mutation_p.R396W	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	396	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4																		---	---	---	---
GATA3	2625	broad.mit.edu	37	10	8100470	8100470	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:8100470G>A	uc001ika.2	+	3	1001	c.444G>A	c.(442-444)CCG>CCA	p.P148P	GATA3_uc001ijz.2_Silent_p.P148P	NM_002051	NP_002042	P23771	GATA3_HUMAN	GATA binding protein 3 isoform 2	148					aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			breast(17)|ovary(3)|central_nervous_system(2)	22								F|N|S		breast		HDR syndrome (HYPOPARATHYROIDISM|SENSORINEURAL DEAFNESS|AND RENAL DISEASE)						---	---	---	---
CDNF	441549	broad.mit.edu	37	10	14867476	14867476	+	Splice_Site	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:14867476A>G	uc001inb.1	-	3	423	c.385_splice	c.e3+1	p.E129_splice	CDNF_uc010qbv.1_Intron|CDNF_uc001inc.1_Splice_Site_p.E20_splice	NM_001029954	NP_001025125			arginine-rich, mutated in early stage							extracellular region	growth factor activity				0																		---	---	---	---
CUBN	8029	broad.mit.edu	37	10	17113976	17113976	+	Intron	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:17113976G>A	uc001ioo.2	-							NM_001081	NP_001072			cubilin precursor						cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)													---	---	---	---
PLXDC2	84898	broad.mit.edu	37	10	20453421	20453421	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:20453421A>T	uc001iqg.1	+	7	1445	c.808A>T	c.(808-810)AGT>TGT	p.S270C	PLXDC2_uc001iqh.1_Missense_Mutation_p.S221C|PLXDC2_uc009xkc.1_RNA	NM_032812	NP_116201	Q6UX71	PXDC2_HUMAN	plexin domain containing 2 precursor	270	Extracellular (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4																		---	---	---	---
NEBL	10529	broad.mit.edu	37	10	21117557	21117557	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:21117557A>G	uc001iqi.2	-	17	2075	c.1678T>C	c.(1678-1680)TAT>CAT	p.Y560H	NEBL_uc001iqj.2_RNA|NEBL_uc001iqk.2_Intron|NEBL_uc001iql.1_RNA	NM_006393	NP_006384	O76041	NEBL_HUMAN	nebulette sarcomeric isoform	560	Nebulin 15.				regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2																		---	---	---	---
PTCHD3	374308	broad.mit.edu	37	10	27702960	27702960	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:27702960C>T	uc001itu.2	-	1	338	c.220G>A	c.(220-222)GCA>ACA	p.A74T		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	74					spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4																		---	---	---	---
SVIL	6840	broad.mit.edu	37	10	29754537	29754537	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:29754537G>A	uc001iut.1	-	34	6873	c.6120C>T	c.(6118-6120)AGC>AGT	p.S2040S	LOC387647_uc001iuo.1_Intron|LOC387647_uc001iup.2_Intron|LOC387647_uc001iuq.1_Intron|SVIL_uc010qdw.1_Silent_p.S954S|SVIL_uc001iuu.1_Silent_p.S1614S	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	2040	Gelsolin-like 5.				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)																---	---	---	---
HNRNPF	3185	broad.mit.edu	37	10	43882582	43882582	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:43882582C>T	uc009xmh.1	-	3	1238	c.751G>A	c.(751-753)GAT>AAT	p.D251N	HNRNPF_uc001jar.2_Missense_Mutation_p.D251N|HNRNPF_uc001jas.2_Missense_Mutation_p.D251N|HNRNPF_uc001jat.2_Missense_Mutation_p.D251N|HNRNPF_uc001jav.2_Missense_Mutation_p.D251N|HNRNPF_uc001jau.2_Missense_Mutation_p.D251N|uc010qfa.1_Silent_p.I88I	NM_001098208	NP_001091678	P52597	HNRPF_HUMAN	heterogeneous nuclear ribonucleoprotein F	251					regulation of RNA splicing	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding				0																		---	---	---	---
ANUBL1	93550	broad.mit.edu	37	10	46121505	46121505	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:46121505C>T	uc001jcp.3	-	7	2008	c.1766G>A	c.(1765-1767)GGC>GAC	p.G589D	ANUBL1_uc001jcl.3_Missense_Mutation_p.G109D|ANUBL1_uc001jcm.3_Missense_Mutation_p.G589D|ANUBL1_uc009xmu.2_Missense_Mutation_p.G515D|ANUBL1_uc001jcn.3_Missense_Mutation_p.G515D|ANUBL1_uc001jco.3_Intron	NM_001128324	NP_001121796	Q86XD8	ANUB1_HUMAN	AN1, ubiquitin-like, homolog	589							zinc ion binding				0																		---	---	---	---
DKK1	22943	broad.mit.edu	37	10	54074209	54074209	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:54074209C>T	uc001jjr.2	+	1	169	c.15C>T	c.(13-15)GGC>GGT	p.G5G	uc001jjq.1_5'Flank|uc009xox.1_5'Flank	NM_012242	NP_036374	O94907	DKK1_HUMAN	dickkopf homolog 1 precursor	5					negative regulation of peptidyl-serine phosphorylation|negative regulation of protein complex assembly|negative regulation of transcription from RNA polymerase II promoter|positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization	extracellular space|plasma membrane	growth factor activity|low-density lipoprotein particle receptor binding|receptor antagonist activity|signal transducer activity			ovary(1)|lung(1)|kidney(1)	3																OREG0020191	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
ZWINT	11130	broad.mit.edu	37	10	58119262	58119262	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:58119262A>G	uc001jjx.1	-	5	492	c.455T>C	c.(454-456)GTC>GCC	p.V152A	ZWINT_uc001jjy.1_Missense_Mutation_p.V152A|ZWINT_uc001jka.1_Missense_Mutation_p.V152A|ZWINT_uc009xoy.1_RNA	NM_007057	NP_008988	O95229	ZWINT_HUMAN	ZW10 interactor isoform a	152	Interaction with NDC80 and ZW10.|Potential.				cell division|establishment of localization in cell|mitotic cell cycle checkpoint|mitotic prometaphase|mitotic sister chromatid segregation|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytosol|nucleus	protein N-terminus binding				0																		---	---	---	---
ANK3	288	broad.mit.edu	37	10	61833637	61833637	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:61833637G>A	uc001jky.2	-	37	7194	c.7002C>T	c.(7000-7002)ATC>ATT	p.I2334I	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	2334					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19																		---	---	---	---
JMJD1C	221037	broad.mit.edu	37	10	64936152	64936152	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:64936152G>A	uc001jmn.2	-	24	7606	c.7306C>T	c.(7306-7308)CGT>TGT	p.R2436C	JMJD1C_uc001jml.2_Missense_Mutation_p.R2199C|JMJD1C_uc001jmm.2_Missense_Mutation_p.R2148C|JMJD1C_uc010qiq.1_Missense_Mutation_p.R2254C|JMJD1C_uc009xpi.2_Missense_Mutation_p.R2254C|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc001jmk.2_RNA	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	2436	JmjC.				blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)																	---	---	---	---
JMJD1C	221037	broad.mit.edu	37	10	64958334	64958334	+	Silent	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:64958334A>G	uc001jmn.2	-	12	5730	c.5430T>C	c.(5428-5430)GGT>GGC	p.G1810G	JMJD1C_uc001jml.2_Silent_p.G1591G|JMJD1C_uc001jmm.2_Silent_p.G1522G|JMJD1C_uc010qiq.1_Silent_p.G1628G|JMJD1C_uc009xpi.2_Silent_p.G1628G|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc009xpk.1_Intron	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	1810					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)																	---	---	---	---
HERC4	26091	broad.mit.edu	37	10	69792621	69792621	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:69792621A>G	uc001jng.3	-	7	1002	c.691T>C	c.(691-693)TAT>CAT	p.Y231H	HERC4_uc001jnf.3_RNA|HERC4_uc001jnh.3_Missense_Mutation_p.Y231H|HERC4_uc009xpr.2_Missense_Mutation_p.Y231H|HERC4_uc001jni.3_Intron|HERC4_uc001jnj.2_Missense_Mutation_p.Y231H	NM_022079	NP_071362	Q5GLZ8	HERC4_HUMAN	hect domain and RLD 4 isoform a	231	RCC1 5.				cell differentiation|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|spermatogenesis	cytosol	ubiquitin-protein ligase activity			ovary(1)|breast(1)|skin(1)	3																		---	---	---	---
HK1	3098	broad.mit.edu	37	10	71144668	71144668	+	Silent	SNP	C	T	T	rs143834023		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:71144668C>T	uc001jpl.3	+	12	1937	c.1836C>T	c.(1834-1836)GAC>GAT	p.D612D	HK1_uc001jpg.3_Silent_p.D600D|HK1_uc001jph.3_Silent_p.D616D|HK1_uc001jpi.3_Silent_p.D616D|HK1_uc001jpj.3_Silent_p.D647D|HK1_uc001jpk.3_Silent_p.D611D|HK1_uc009xqd.2_Silent_p.D490D	NM_000188	NP_000179	P19367	HXK1_HUMAN	hexokinase 1 isoform HKI	612	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			ovary(1)	1																		---	---	---	---
CHST3	9469	broad.mit.edu	37	10	73767332	73767332	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:73767332C>T	uc001jsn.2	+	3	983	c.543C>T	c.(541-543)GCC>GCT	p.A181A		NM_004273	NP_004264	Q7LGC8	CHST3_HUMAN	chondroitin 6-sulfotransferase 3	181	Lumenal (Potential).				chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 6-sulfotransferase activity				0																		---	---	---	---
SEC24C	9632	broad.mit.edu	37	10	75530210	75530210	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:75530210G>A	uc001juw.2	+	22	3214	c.3035G>A	c.(3034-3036)AGT>AAT	p.S1012N	SEC24C_uc001jux.2_Missense_Mutation_p.S1012N|SEC24C_uc010qko.1_Missense_Mutation_p.S893N|SEC24C_uc010qkp.1_Missense_Mutation_p.S260N|SEC24C_uc010qkq.1_Missense_Mutation_p.S260N|FUT11_uc001juy.1_5'Flank|FUT11_uc001juz.1_5'Flank|FUT11_uc001jva.2_5'Flank	NM_004922	NP_004913	P53992	SC24C_HUMAN	SEC24-related protein C	1012					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|zinc ion binding			skin(2)|central_nervous_system(1)	3	Prostate(51;0.0112)																	---	---	---	---
KIAA0913	23053	broad.mit.edu	37	10	75560431	75560431	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:75560431C>T	uc009xrl.2	+	24	5077	c.5045C>T	c.(5044-5046)GCA>GTA	p.A1682V	KIAA0913_uc001jve.2_Missense_Mutation_p.A1687V|KIAA0913_uc001jvf.2_Missense_Mutation_p.A1500V|KIAA0913_uc001jvh.2_RNA|KIAA0913_uc001jvi.2_Missense_Mutation_p.A1109V|KIAA0913_uc010qkr.1_Missense_Mutation_p.A1097V|KIAA0913_uc001jvj.2_Missense_Mutation_p.A1097V|KIAA0913_uc009xrn.1_Missense_Mutation_p.A93V	NM_015037	NP_055852	A7E2V4	K0913_HUMAN	hypothetical protein LOC23053	1682							zinc ion binding			breast(1)	1	Prostate(51;0.0112)																	---	---	---	---
VCL	7414	broad.mit.edu	37	10	75834640	75834640	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:75834640T>C	uc001jwd.2	+	6	856	c.762T>C	c.(760-762)GAT>GAC	p.D254D	VCL_uc009xrr.2_5'UTR|VCL_uc010qky.1_Silent_p.D161D|VCL_uc001jwe.2_Silent_p.D254D|VCL_uc010qkz.1_Intron	NM_014000	NP_054706	P18206	VINC_HUMAN	vinculin isoform meta-VCL	254	N-terminal globular head.				adherens junction assembly|apical junction assembly|cell-matrix adhesion|cellular component movement|epithelial cell-cell adhesion|lamellipodium assembly|morphogenesis of an epithelium|muscle contraction|negative regulation of cell migration|platelet activation|platelet degranulation|protein localization at cell surface	costamere|cytosol|extracellular region|focal adhesion	actin binding|alpha-catenin binding|beta-catenin binding|beta-dystroglycan binding|cadherin binding|structural molecule activity		VCL/ALK(4)	kidney(4)|ovary(1)|central_nervous_system(1)	6	Prostate(51;0.0112)																	---	---	---	---
MYST4	23522	broad.mit.edu	37	10	76790391	76790391	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:76790391G>A	uc001jwn.1	+	18	6302	c.5809G>A	c.(5809-5811)GCC>ACC	p.A1937T	MYST4_uc001jwo.1_Missense_Mutation_p.A1645T|MYST4_uc001jwp.1_Missense_Mutation_p.A1754T	NM_012330	NP_036462	Q8WYB5	MYST4_HUMAN	MYST histone acetyltransferase (monocytic	1937	Interaction with RUNX1 and RUNX2.				histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|breast(2)|skin(1)|prostate(1)	16	all_cancers(46;0.0347)|all_epithelial(25;0.00236)|Prostate(51;0.0112)|Ovarian(15;0.0964)							T	CREBBP	AML								---	---	---	---
DLG5	9231	broad.mit.edu	37	10	79567608	79567608	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:79567608C>T	uc001jzk.2	-	25	4812	c.4742G>A	c.(4741-4743)CGC>CAC	p.R1581H	DLG5_uc001jzi.2_Missense_Mutation_p.R336H|DLG5_uc001jzj.2_Missense_Mutation_p.R996H|DLG5_uc009xru.1_RNA	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	1581	PDZ 4.				cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)															---	---	---	---
POLR3A	11128	broad.mit.edu	37	10	79745713	79745713	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:79745713T>C	uc001jzn.2	-	23	3113	c.3019A>G	c.(3019-3021)ACC>GCC	p.T1007A		NM_007055	NP_008986	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	1007					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding				0	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)															---	---	---	---
LRIT2	340745	broad.mit.edu	37	10	85984521	85984521	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:85984521T>A	uc001kcy.2	-	2	468	c.460A>T	c.(460-462)ACC>TCC	p.T154S	LRIT2_uc010qmc.1_Missense_Mutation_p.T154S	NM_001017924	NP_001017924	A6NDA9	LRIT2_HUMAN	leucine rich repeat containing 22 precursor	154	LRR 4.					integral to membrane				ovary(2)	2																		---	---	---	---
WAPAL	23063	broad.mit.edu	37	10	88211855	88211855	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:88211855T>C	uc001kdo.2	-	15	3425	c.2983A>G	c.(2983-2985)AGT>GGT	p.S995G	WAPAL_uc009xsv.2_Intron|WAPAL_uc001kdn.2_Missense_Mutation_p.S1032G|WAPAL_uc009xsw.2_Missense_Mutation_p.S989G	NM_015045	NP_055860	Q7Z5K2	WAPL_HUMAN	wings apart-like homolog	995	WAPL.				cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			ovary(1)	1																		---	---	---	---
GLUD1	2746	broad.mit.edu	37	10	88820771	88820771	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:88820771T>C	uc001keh.2	-	7	1057	c.960A>G	c.(958-960)TTA>TTG	p.L320L	GLUD1_uc001keg.2_Silent_p.L153L|GLUD1_uc010qmp.1_Silent_p.L187L	NM_005271	NP_005262	P00367	DHE3_HUMAN	glutamate dehydrogenase 1 precursor	320					glutamate biosynthetic process|glutamate catabolic process|positive regulation of insulin secretion	mitochondrial matrix	ADP binding|ATP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|identical protein binding|leucine binding|NAD+ binding				0					L-Glutamic Acid(DB00142)|NADH(DB00157)													---	---	---	---
ACTA2	59	broad.mit.edu	37	10	90701123	90701123	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:90701123C>G	uc001kfp.2	-	6	595	c.479G>C	c.(478-480)GGT>GCT	p.G160A	STAMBPL1_uc010qmx.1_Intron|ACTA2_uc010qmy.1_Missense_Mutation_p.G115A|ACTA2_uc001kfq.2_Missense_Mutation_p.G160A	NM_001613	NP_001604	P62736	ACTA_HUMAN	alpha 2 actin	160					response to virus	cytosol	ATP binding				0		Colorectal(252;0.0161)		Colorectal(12;0.000123)|COAD - Colon adenocarcinoma(12;0.00018)														---	---	---	---
MYOF	26509	broad.mit.edu	37	10	95079635	95079635	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:95079635C>T	uc001kin.2	-	49	5715	c.5592G>A	c.(5590-5592)GCG>GCA	p.A1864A	MYOF_uc001kio.2_Silent_p.A1851A|MYOF_uc009xue.2_RNA	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	1864	Cytoplasmic (Potential).				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4																		---	---	---	---
GPR120	338557	broad.mit.edu	37	10	95347331	95347331	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:95347331G>A	uc010qnt.1	+	4	1155	c.1099G>A	c.(1099-1101)GTC>ATC	p.V367I	GPR120_uc010qnu.1_Missense_Mutation_p.V351I	NM_181745	NP_859529	Q5NUL3	O3FA1_HUMAN	G protein-coupled receptor 120	367	Cytoplasmic (Potential).				negative regulation of cytokine secretion|negative regulation of inflammatory response|regulation of glucose transport	integral to membrane|plasma membrane	fatty acid binding				0		Colorectal(252;0.122)																---	---	---	---
ENTPD1	953	broad.mit.edu	37	10	97620351	97620351	+	Intron	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:97620351G>A	uc001klh.3	+						ENTPD1_uc001kli.3_Intron|uc001klg.1_Intron|ENTPD1_uc010qoj.1_Intron|ENTPD1_uc010qok.1_Intron|ENTPD1_uc010qol.1_Intron|ENTPD1_uc010qom.1_Intron|ENTPD1_uc010qon.1_Intron|ENTPD1_uc009xva.2_Intron|ENTPD1_uc009xuz.2_Intron	NM_001776	NP_001767			ectonucleoside triphosphate diphosphohydrolase 1						cell adhesion	integral to plasma membrane	ATP binding			ovary(3)	3		Colorectal(252;0.0821)		Epithelial(162;1.31e-07)|all cancers(201;5.33e-06)														---	---	---	---
BLNK	29760	broad.mit.edu	37	10	97975104	97975104	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:97975104G>A	uc001kls.3	-	8	827	c.649C>T	c.(649-651)CCC>TCC	p.P217S	BLNK_uc001kme.3_Intron|BLNK_uc001klt.3_Intron|BLNK_uc009xvc.2_Intron|BLNK_uc001klu.3_Missense_Mutation_p.P135S|BLNK_uc001klv.3_Intron|BLNK_uc001klw.3_Intron|BLNK_uc001klx.3_Intron|BLNK_uc001kly.3_Missense_Mutation_p.P217S|BLNK_uc001klz.3_Intron|BLNK_uc001kma.3_Intron|BLNK_uc001kmb.3_Missense_Mutation_p.P13S|BLNK_uc001kmc.3_Intron|BLNK_uc001kmd.3_Missense_Mutation_p.P135S|BLNK_uc009xvd.2_Intron	NM_013314	NP_037446	Q8WV28	BLNK_HUMAN	B-cell linker isoform 1	217	Pro-rich.				B cell differentiation|humoral immune response|inflammatory response|intracellular signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(2)	2		Colorectal(252;0.083)		Epithelial(162;7.89e-08)|all cancers(201;2.27e-06)														---	---	---	---
C10orf12	26148	broad.mit.edu	37	10	98743674	98743674	+	Nonsense_Mutation	SNP	A	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:98743674A>T	uc001kmv.2	+	1	2634	c.2527A>T	c.(2527-2529)AAA>TAA	p.K843*		NM_015652	NP_056467	Q8N655	CJ012_HUMAN	hypothetical protein LOC26148	843										skin(2)	2		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)														---	---	---	---
SEC31B	25956	broad.mit.edu	37	10	102265260	102265260	+	Intron	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:102265260G>A	uc001krc.1	-						SEC31B_uc010qpo.1_Intron|SEC31B_uc001krd.1_5'UTR|SEC31B_uc001krf.1_Intron|SEC31B_uc001kre.1_5'UTR|SEC31B_uc001krg.1_5'UTR|SEC31B_uc010qpp.1_3'UTR|SEC31B_uc009xwn.1_3'UTR|SEC31B_uc009xwo.1_3'UTR|SEC31B_uc010qpq.1_3'UTR	NM_015490	NP_056305			SEC31 homolog B						protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				ovary(1)	1		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)														---	---	---	---
FAM178A	55719	broad.mit.edu	37	10	102676537	102676537	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:102676537G>A	uc001krt.3	+	3	937	c.395G>A	c.(394-396)CGT>CAT	p.R132H	FAM178A_uc001krr.1_Missense_Mutation_p.R132H|FAM178A_uc001krs.2_Missense_Mutation_p.R132H|FAM178A_uc001kru.1_Missense_Mutation_p.R68H	NM_018121	NP_060591	Q8IX21	F178A_HUMAN	hypothetical protein LOC55719 isoform 1	132											0																		---	---	---	---
BTRC	8945	broad.mit.edu	37	10	103221770	103221770	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:103221770C>T	uc001kta.2	+	3	302	c.189C>T	c.(187-189)GGC>GGT	p.G63G	BTRC_uc001ksz.1_Intron|BTRC_uc001ktb.2_Silent_p.G27G|BTRC_uc001ktc.2_Intron	NM_033637	NP_378663	Q9Y297	FBW1A_HUMAN	beta-transducin repeat containing protein	63					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|positive regulation of proteolysis|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|viral reproduction|Wnt receptor signaling pathway	cytosol|nucleus|SCF ubiquitin ligase complex				ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;1.05e-08)|all cancers(201;6.59e-07)														---	---	---	---
MGEA5	10724	broad.mit.edu	37	10	103558790	103558790	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:103558790G>A	uc001ktv.2	-	9	2061	c.1618C>T	c.(1618-1620)CCA>TCA	p.P540S	MGEA5_uc001ktu.2_RNA|MGEA5_uc010qqe.1_Missense_Mutation_p.P487S|MGEA5_uc009xws.2_Missense_Mutation_p.P487S|MGEA5_uc001ktw.2_Missense_Mutation_p.P540S|MGEA5_uc009xwt.2_Missense_Mutation_p.P303S	NM_012215	NP_036347	O60502	NCOAT_HUMAN	meningioma expressed antigen 5 (hyaluronidase)	540					glycoprotein catabolic process	cytoplasm|nucleus	histone acetyltransferase activity|hyalurononglucosaminidase activity			ovary(2)|skin(1)	3		Colorectal(252;0.207)		Epithelial(162;4.67e-09)|all cancers(201;2.54e-07)														---	---	---	---
PSD	5662	broad.mit.edu	37	10	104164452	104164452	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:104164452C>T	uc001kvg.1	-	15	3115	c.2588G>A	c.(2587-2589)CGC>CAC	p.R863H	PSD_uc001kve.1_Missense_Mutation_p.R71H|PSD_uc001kvf.1_Missense_Mutation_p.R232H|PSD_uc001kvh.1_Missense_Mutation_p.R484H|PSD_uc009xxd.1_Missense_Mutation_p.R863H	NM_002779	NP_002770	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	863	PH.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|urinary_tract(1)	3				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)														---	---	---	---
TRIM8	81603	broad.mit.edu	37	10	104414974	104414974	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:104414974G>A	uc001kvz.2	+	3	927	c.804G>A	c.(802-804)CAG>CAA	p.Q268Q		NM_030912	NP_112174	Q9BZR9	TRIM8_HUMAN	tripartite motif-containing 8	268						cytoplasm|PML body	ligase activity|protein homodimerization activity|zinc ion binding			ovary(1)	1		Colorectal(252;0.122)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)														---	---	---	---
SFXN2	118980	broad.mit.edu	37	10	104491919	104491919	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:104491919C>T	uc001kwb.2	+	8	831	c.665C>T	c.(664-666)GCC>GTC	p.A222V	SFXN2_uc001kwc.2_Intron|SFXN2_uc001kwd.2_Intron	NM_178858	NP_849189	Q96NB2	SFXN2_HUMAN	sideroflexin 2	222					iron ion homeostasis	integral to membrane	cation transmembrane transporter activity				0		Colorectal(252;0.207)		Epithelial(162;4.53e-09)|all cancers(201;1.2e-07)|BRCA - Breast invasive adenocarcinoma(275;0.218)														---	---	---	---
PDCD11	22984	broad.mit.edu	37	10	105172931	105172931	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:105172931G>A	uc001kwy.1	+	9	1124	c.1037G>A	c.(1036-1038)CGC>CAC	p.R346H		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	346	S1 motif 3.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)														---	---	---	---
CALHM1	255022	broad.mit.edu	37	10	105215352	105215352	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:105215352C>T	uc001kxe.2	-	2	848	c.708G>A	c.(706-708)ACG>ACA	p.T236T	CALHM2_uc001kxd.1_5'Flank	NM_001001412	NP_001001412	Q8IU99	CAHM1_HUMAN	calcium homeostasis modulator 1	236						endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel activity|identical protein binding			ovary(1)	1																		---	---	---	---
SLK	9748	broad.mit.edu	37	10	105727517	105727517	+	Missense_Mutation	SNP	A	T	T	rs150455513		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:105727517A>T	uc001kxo.1	+	1	48	c.14A>T	c.(13-15)AAT>ATT	p.N5I	SLK_uc001kxp.1_Missense_Mutation_p.N5I	NM_014720	NP_055535	Q9H2G2	SLK_HUMAN	serine/threonine kinase 2	5				N -> S (in Ref. 3; BAA13195).	apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			ovary(2)|stomach(2)|skin(2)|lung(1)|kidney(1)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)														---	---	---	---
C10orf118	55088	broad.mit.edu	37	10	115917415	115917415	+	Silent	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:115917415A>G	uc001lbb.1	-	3	1309	c.657T>C	c.(655-657)CAT>CAC	p.H219H	C10orf118_uc001lbc.1_Silent_p.H219H|C10orf118_uc009xye.1_RNA	NM_018017	NP_060487	Q7Z3E2	CJ118_HUMAN	CTCL tumor antigen L14-2	219	Potential.									ovary(2)	2		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0161)|all cancers(201;0.0397)														---	---	---	---
AFAP1L2	84632	broad.mit.edu	37	10	116057097	116057097	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:116057097C>T	uc001lbn.2	-	17	2490	c.2189G>A	c.(2188-2190)CGC>CAC	p.R730H	AFAP1L2_uc001lbo.2_Missense_Mutation_p.R730H|AFAP1L2_uc010qse.1_Missense_Mutation_p.R783H|AFAP1L2_uc001lbp.2_Missense_Mutation_p.R758H|AFAP1L2_uc001lbm.2_Missense_Mutation_p.R169H|AFAP1L2_uc010qsd.1_Missense_Mutation_p.R296H|AFAP1L2_uc001lbq.1_Missense_Mutation_p.R252H	NM_001001936	NP_001001936	Q8N4X5	AF1L2_HUMAN	KIAA1914 protein isoform 1	730	Potential.				inflammatory response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of transcription, DNA-dependent|regulation of interleukin-6 production|regulation of mitotic cell cycle	cytoplasm	protein tyrosine kinase activator activity|SH2 domain binding|SH3 domain binding			ovary(1)|breast(1)	2		Colorectal(252;0.175)|Breast(234;0.231)		Epithelial(162;0.0219)|all cancers(201;0.0561)														---	---	---	---
PNLIPRP3	119548	broad.mit.edu	37	10	118196370	118196370	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:118196370C>T	uc001lcl.3	+	2	298	c.197C>T	c.(196-198)GCC>GTC	p.A66V		NM_001011709	NP_001011709	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3 precursor	66					lipid catabolic process	extracellular region	triglyceride lipase activity			ovary(1)	1				all cancers(201;0.0131)														---	---	---	---
VAX1	11023	broad.mit.edu	37	10	118897523	118897523	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:118897523G>A	uc009xyx.2	-	1	290	c.45C>T	c.(43-45)GAC>GAT	p.D15D	VAX1_uc001ldb.1_Silent_p.D15D	NM_001112704	NP_001106175	Q5SQQ9	VAX1_HUMAN	ventral anterior homeobox 1 isoform a	15						nucleus	sequence-specific DNA binding			ovary(2)	2				all cancers(201;0.0108)														---	---	---	---
PRLHR	2834	broad.mit.edu	37	10	120354266	120354266	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:120354266A>G	uc001ldp.1	-	2	630	c.491T>C	c.(490-492)GTG>GCG	p.V164A		NM_004248	NP_004239	P49683	PRLHR_HUMAN	G protein-coupled receptor 10	164	Cytoplasmic (Potential).				female pregnancy	integral to plasma membrane	neuropeptide Y receptor activity				0		Colorectal(252;0.0429)|Lung NSC(174;0.142)|all_lung(145;0.175)		all cancers(201;0.0166)														---	---	---	---
TACC2	10579	broad.mit.edu	37	10	123847469	123847469	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:123847469T>C	uc001lfv.2	+	4	5814	c.5454T>C	c.(5452-5454)ACT>ACC	p.T1818T	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Silent_p.T1818T|TACC2_uc010qtv.1_Silent_p.T1818T	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	1818						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)																---	---	---	---
FAM53B	9679	broad.mit.edu	37	10	126370273	126370273	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:126370273G>A	uc001lhv.1	-	4	1332	c.809C>T	c.(808-810)CCG>CTG	p.P270L	FAM53B_uc001lhu.1_Missense_Mutation_p.P270L|FAM53B_uc001lhw.2_Missense_Mutation_p.P270L	NM_014661	NP_055476	Q14153	FA53B_HUMAN	hypothetical protein LOC9679	270										ovary(1)|pancreas(1)	2		all_lung(145;0.0191)|Lung NSC(174;0.0301)|Colorectal(57;0.106)|all_neural(114;0.117)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.15)														---	---	---	---
MKI67	4288	broad.mit.edu	37	10	129908709	129908709	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:129908709C>G	uc001lke.2	-	12	2544	c.2349G>C	c.(2347-2349)TTG>TTC	p.L783F	MKI67_uc001lkf.2_Missense_Mutation_p.L423F|MKI67_uc009yav.1_Missense_Mutation_p.L358F|MKI67_uc009yaw.1_Intron	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	783					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)																---	---	---	---
BNIP3	664	broad.mit.edu	37	10	133784266	133784266	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:133784266G>A	uc001lkv.1	-	5	541	c.415C>T	c.(415-417)CGC>TGC	p.R139C	BNIP3_uc001lku.1_5'Flank|BNIP3_uc010qut.1_Missense_Mutation_p.R139C	NM_004052	NP_004043	Q12983	BNIP3_HUMAN	BCL2/adenovirus E1B 19kD-interacting protein 3	139					cellular response to cobalt ion|cellular response to hypoxia|cellular response to mechanical stimulus|chromatin remodeling|defense response to virus|DNA fragmentation involved in apoptotic nuclear change|induction of apoptosis|interspecies interaction between organisms|mitochondrial fragmentation involved in apoptosis|negative regulation of membrane potential|negative regulation of mitochondrial fusion|negative regulation of survival gene product expression|neuron apoptosis|positive regulation of mitochondrial fission|positive regulation of protein complex disassembly|positive regulation of release of cytochrome c from mitochondria|reactive oxygen species metabolic process|regulation of mitochondrial membrane permeability	dendrite|integral to mitochondrial outer membrane|nuclear envelope|nucleoplasm	GTPase binding|protein heterodimerization activity|protein homodimerization activity			lung(1)|skin(1)	2		all_cancers(35;4e-11)|all_epithelial(44;5.07e-08)|Ovarian(717;2.61e-05)|Lung NSC(174;0.00237)|all_lung(145;0.00354)|Breast(234;0.023)|all_neural(114;0.0299)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)		Epithelial(32;1.59e-12)|all cancers(32;3.75e-11)|OV - Ovarian serous cystadenocarcinoma(35;2.57e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)														---	---	---	---
RNH1	6050	broad.mit.edu	37	11	502079	502079	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:502079C>T	uc001lpk.1	-	1	1492	c.84G>A	c.(82-84)CAG>CAA	p.Q28Q	RNH1_uc001lpl.1_Silent_p.Q28Q|RNH1_uc001lpm.1_Silent_p.Q28Q|RNH1_uc001lpn.1_Silent_p.Q28Q|RNH1_uc001lpo.1_Silent_p.Q28Q|RNH1_uc009ybw.1_RNA|RNH1_uc001lpp.1_Silent_p.Q28Q|RNH1_uc001lpt.1_5'UTR|RNH1_uc001lpq.1_Silent_p.Q28Q|RNH1_uc001lpr.1_Silent_p.Q28Q|RNH1_uc001lps.1_Silent_p.Q28Q|RNH1_uc009ybx.1_Silent_p.Q28Q	NM_203389	NP_976323	P13489	RINI_HUMAN	ribonuclease/angiogenin inhibitor	28	LRR 1.				mRNA catabolic process|regulation of angiogenesis	angiogenin-PRI complex|cytoplasm	protein binding|ribonuclease inhibitor activity				0		all_cancers(49;3.02e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;1.26e-26)|Epithelial(43;1.34e-25)|OV - Ovarian serous cystadenocarcinoma(40;5.31e-20)|BRCA - Breast invasive adenocarcinoma(625;8.01e-05)|Lung(200;0.0378)|LUSC - Lung squamous cell carcinoma(625;0.0703)														---	---	---	---
PHRF1	57661	broad.mit.edu	37	11	596998	596998	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:596998G>A	uc001lqe.2	+	7	827	c.696G>A	c.(694-696)GCG>GCA	p.A232A	PHRF1_uc010qwc.1_Silent_p.A232A|PHRF1_uc010qwd.1_Silent_p.A231A|PHRF1_uc010qwe.1_Silent_p.A228A|PHRF1_uc009ybz.1_Silent_p.A23A	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	232	PHD-type.						RNA polymerase binding|zinc ion binding				0																		---	---	---	---
CDHR5	53841	broad.mit.edu	37	11	621608	621608	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:621608C>T	uc001lqj.2	-	5	566	c.461G>A	c.(460-462)CGC>CAC	p.R154H	CDHR5_uc001lqk.2_Missense_Mutation_p.R154H|CDHR5_uc009ycc.2_5'UTR|CDHR5_uc009ycd.2_Missense_Mutation_p.R154H|CDHR5_uc001lql.2_Missense_Mutation_p.R154H|CDHR5_uc001lqm.2_5'UTR|CDHR5_uc009yce.1_Missense_Mutation_p.R123H	NM_021924	NP_068743	Q9HBB8	CDHR5_HUMAN	mucin and cadherin-like isoform 1	154	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0																		---	---	---	---
MUC5B	727897	broad.mit.edu	37	11	1261421	1261421	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:1261421C>T	uc009ycr.1	+	46	5991	c.5865C>T	c.(5863-5865)ACC>ACT	p.T1955T	MUC5B_uc001ltb.2_Silent_p.T1265T|MUC5B_uc001lta.2_Silent_p.T930T	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	1262					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)														---	---	---	---
CARS	833	broad.mit.edu	37	11	3023796	3023796	+	Missense_Mutation	SNP	G	A	A	rs141404196		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:3023796G>A	uc001lxh.2	-	20	2077	c.2003C>T	c.(2002-2004)GCG>GTG	p.A668V	CARS_uc009ydu.2_Intron|CARS_uc001lxe.2_Missense_Mutation_p.A658V|CARS_uc001lxf.2_Missense_Mutation_p.A751V|CARS_uc001lxg.2_Missense_Mutation_p.A668V|CARS_uc010qxo.1_Missense_Mutation_p.A751V|CARS_uc010qxp.1_Missense_Mutation_p.A681V	NM_001751	NP_001742	P49589	SYCC_HUMAN	cysteinyl-tRNA synthetase isoform b	668					cysteinyl-tRNA aminoacylation	cytoplasm|cytosol	ATP binding|cysteine-tRNA ligase activity|metal ion binding|protein homodimerization activity|protein homodimerization activity|tRNA binding|tRNA binding		CARS/ALK(5)	soft_tissue(5)|ovary(2)	7		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00317)|LUSC - Lung squamous cell carcinoma(625;0.218)	L-Cysteine(DB00151)			T	ALK	ALCL								---	---	---	---
STIM1	6786	broad.mit.edu	37	11	4080587	4080587	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:4080587C>T	uc001lyv.2	+	5	1142	c.574C>T	c.(574-576)CTG>TTG	p.L192L	STIM1_uc009yef.2_Silent_p.L192L|STIM1_uc009yeg.2_Silent_p.L19L	NM_003156	NP_003147	Q13586	STIM1_HUMAN	stromal interaction molecule 1 precursor	192	SAM.|Extracellular (Potential).				activation of store-operated calcium channel activity|calcium ion transport|detection of calcium ion|platelet activation	integral to endoplasmic reticulum membrane|integral to plasma membrane|microtubule	calcium ion binding|microtubule plus-end binding			pancreas(1)	1		Breast(177;0.00159)|Medulloblastoma(188;0.00258)|all_neural(188;0.0233)		BRCA - Breast invasive adenocarcinoma(625;0.114)|LUSC - Lung squamous cell carcinoma(625;0.141)														---	---	---	---
RRM1	6240	broad.mit.edu	37	11	4133248	4133248	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:4133248G>A	uc001lyw.3	+	7	925	c.606G>A	c.(604-606)TCG>TCA	p.S202S	RRM1_uc009yeh.1_Silent_p.S105S|RRM1_uc009yei.2_Silent_p.S162S|RRM1_uc010qyc.1_Silent_p.S105S	NM_001033	NP_001024	P23921	RIR1_HUMAN	ribonucleoside-diphosphate reductase M1 chain	202		Substrate (By similarity).			deoxyribonucleotide biosynthetic process|DNA replication|nucleobase, nucleoside and nucleotide interconversion	cytosol|nucleoplasm|ribonucleoside-diphosphate reductase complex	ATP binding|ribonucleoside-diphosphate reductase activity			skin(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.00502)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0848)|LUSC - Lung squamous cell carcinoma(625;0.205)	Clofarabine(DB00631)|Fludarabine(DB01073)|Gemcitabine(DB00441)|Hydroxyurea(DB01005)													---	---	---	---
OR51V1	283111	broad.mit.edu	37	11	5221605	5221605	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:5221605T>C	uc010qyz.1	-	1	326	c.326A>G	c.(325-327)CAG>CGG	p.Q109R		NM_001004760	NP_001004760	Q9H2C8	O51V1_HUMAN	olfactory receptor, family 51, subfamily V,	109	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.83e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)														---	---	---	---
DCHS1	8642	broad.mit.edu	37	11	6655386	6655386	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:6655386G>T	uc001mem.1	-	3	2359	c.1949C>A	c.(1948-1950)CCC>CAC	p.P650H		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	650	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)														---	---	---	---
NLRP10	338322	broad.mit.edu	37	11	7981709	7981709	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:7981709G>T	uc001mfv.1	-	2	1467	c.1450C>A	c.(1450-1452)CAA>AAA	p.Q484K		NM_176821	NP_789791	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	484	NACHT.						ATP binding			lung(4)|ovary(2)|pancreas(1)|kidney(1)|skin(1)	9				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)														---	---	---	---
NLRP10	338322	broad.mit.edu	37	11	7982707	7982707	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:7982707G>A	uc001mfv.1	-	2	469	c.452C>T	c.(451-453)ACG>ATG	p.T151M		NM_176821	NP_789791	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	151							ATP binding			lung(4)|ovary(2)|pancreas(1)|kidney(1)|skin(1)	9				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)														---	---	---	---
STK33	65975	broad.mit.edu	37	11	8496404	8496404	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:8496404A>G	uc001mgi.1	-	1	968	c.49T>C	c.(49-51)TCA>CCA	p.S17P	STK33_uc001mgj.1_Missense_Mutation_p.S17P|STK33_uc001mgk.1_Missense_Mutation_p.S17P|STK33_uc010rbn.1_Intron|STK33_uc001mgl.3_Intron|STK33_uc009yfp.2_Intron	NM_030906	NP_112168	Q9BYT3	STK33_HUMAN	serine/threonine kinase 33	17						Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|pancreas(1)|central_nervous_system(1)|skin(1)	7				Epithelial(150;2.13e-06)|BRCA - Breast invasive adenocarcinoma(625;0.239)														---	---	---	---
ZNF143	7702	broad.mit.edu	37	11	9499965	9499965	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:9499965G>A	uc001mhr.2	+	6	520	c.402G>A	c.(400-402)GCG>GCA	p.A134A	ZNF143_uc009yfu.2_Silent_p.A133A|ZNF143_uc010rby.1_Silent_p.A103A	NM_003442	NP_003433	P52747	ZN143_HUMAN	zinc finger protein 143	134					regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding|zinc ion binding				0				all cancers(16;4.12e-09)|Epithelial(150;2.29e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0212)														---	---	---	---
AMPD3	272	broad.mit.edu	37	11	10508889	10508889	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:10508889G>T	uc001mio.1	+	6	1252	c.917G>T	c.(916-918)CGG>CTG	p.R306L	AMPD3_uc010rbz.1_Missense_Mutation_p.R147L|AMPD3_uc001min.1_Missense_Mutation_p.R315L|AMPD3_uc009yfw.1_RNA|AMPD3_uc009yfz.2_RNA|AMPD3_uc001mip.1_Missense_Mutation_p.R313L|AMPD3_uc009yfy.2_Missense_Mutation_p.R306L	NM_001025389	NP_001020560	Q01432	AMPD3_HUMAN	adenosine monophosphate deaminase 3 isoform 1B	306					AMP catabolic process|purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			large_intestine(1)|ovary(1)	2				all cancers(16;1.14e-08)|Epithelial(150;2.83e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0291)														---	---	---	---
GALNTL4	374378	broad.mit.edu	37	11	11643032	11643032	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:11643032C>T	uc001mjo.2	-	1	530	c.109G>A	c.(109-111)GCC>ACC	p.A37T		NM_198516	NP_940918	Q6P9A2	GLTL4_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	37	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0				all cancers(16;3.67e-05)|Epithelial(150;0.000184)														---	---	---	---
PSMA1	5682	broad.mit.edu	37	11	14529273	14529273	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:14529273T>C	uc001mlk.2	-	9	810	c.664A>G	c.(664-666)ACA>GCA	p.T222A	PSMA1_uc001mll.2_Missense_Mutation_p.T228A|PSMA1_uc010rcp.1_RNA|PSMA1_uc001mlj.2_Missense_Mutation_p.T197A	NM_002786	NP_002777	P25786	PSA1_HUMAN	proteasome alpha 1 subunit isoform 2	222					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|polysome|proteasome core complex, alpha-subunit complex	protein binding|RNA binding|threonine-type endopeptidase activity			upper_aerodigestive_tract(1)|skin(1)	2																		---	---	---	---
ABCC8	6833	broad.mit.edu	37	11	17449860	17449860	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:17449860G>A	uc001mnc.2	-	14	2142	c.2016C>T	c.(2014-2016)GGC>GGT	p.G672G		NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	672	Cytoplasmic (By similarity).				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)													---	---	---	---
USH1C	10083	broad.mit.edu	37	11	17531369	17531369	+	Intron	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:17531369G>A	uc001mnf.2	-						USH1C_uc001mne.2_Missense_Mutation_p.P516L|USH1C_uc009yhb.2_Intron|USH1C_uc001mng.2_Intron|USH1C_uc001mnd.2_Intron	NM_005709	NP_005700			harmonin isoform a						equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			ovary(1)	1																		---	---	---	---
SERGEF	26297	broad.mit.edu	37	11	17809839	17809839	+	Silent	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:17809839G>T	uc001mnm.2	-	11	1250	c.1170C>A	c.(1168-1170)GGC>GGA	p.G390G	SERGEF_uc009yhd.2_RNA|SERGEF_uc001mnn.2_3'UTR	NM_012139	NP_036271	Q9UGK8	SRGEF_HUMAN	deafness locus associated putative guanine	390	RCC1 7.				negative regulation of protein secretion|signal transduction	cytoplasm|nucleus	protein binding|Ran guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1																		---	---	---	---
E2F8	79733	broad.mit.edu	37	11	19256510	19256510	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:19256510G>A	uc001mpm.2	-	5	1069	c.547C>T	c.(547-549)CGA>TGA	p.R183*	E2F8_uc009yhv.2_RNA|E2F8_uc001mpn.3_Nonsense_Mutation_p.R183*	NM_024680	NP_078956	A0AVK6	E2F8_HUMAN	E2F family member 8	183					cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1																		---	---	---	---
NAV2	89797	broad.mit.edu	37	11	20066528	20066528	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:20066528G>A	uc010rdm.1	+	15	3644	c.3283G>A	c.(3283-3285)GCA>ACA	p.A1095T	NAV2_uc001mpp.2_Missense_Mutation_p.A1008T|NAV2_uc001mpr.3_Missense_Mutation_p.A1072T|NAV2_uc001mpt.2_Missense_Mutation_p.A158T|NAV2_uc009yhx.2_Missense_Mutation_p.A158T|NAV2_uc009yhy.1_Missense_Mutation_p.A71T	NM_145117	NP_660093	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 2	1095						nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6																		---	---	---	---
ANO3	63982	broad.mit.edu	37	11	26529809	26529809	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:26529809G>A	uc001mqt.3	+	5	736	c.591G>A	c.(589-591)GAG>GAA	p.E197E	ANO3_uc010rdr.1_Silent_p.E181E|ANO3_uc010rds.1_Silent_p.E51E|ANO3_uc010rdt.1_Silent_p.E51E	NM_031418	NP_113606	Q9BYT9	ANO3_HUMAN	transmembrane protein 16C	197	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4																		---	---	---	---
KIF18A	81930	broad.mit.edu	37	11	28112174	28112174	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:28112174G>T	uc001msc.2	-	5	871	c.689C>A	c.(688-690)GCT>GAT	p.A230D		NM_031217	NP_112494	Q8NI77	KI18A_HUMAN	kinesin family member 18A	230	Kinesin-motor.				blood coagulation|microtubule depolymerization|microtubule-based movement|mitotic metaphase plate congression|mitotic prometaphase|protein transport	caveola|cytosol|kinetochore microtubule|microtubule organizing center|nucleus|ruffle	actin binding|ATP binding|microtubule plus-end binding|plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity|ubiquitin binding			ovary(2)	2																		---	---	---	---
PAX6	5080	broad.mit.edu	37	11	31824246	31824246	+	Intron	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:31824246G>A	uc001mtd.3	-						PAX6_uc001mte.3_Intron|PAX6_uc001mtg.3_Intron|PAX6_uc001mtf.3_Intron|PAX6_uc001mth.3_Intron|PAX6_uc009yjr.2_Intron	NM_001127612	NP_001121084			paired box gene 6 isoform a						blood vessel development|central nervous system development|cornea development in camera-type eye|glucose homeostasis|iris morphogenesis|negative regulation of neurogenesis|neuron fate commitment|pancreatic A cell development|positive regulation of transcription, DNA-dependent|response to wounding|visual perception	cytoplasm|nuclear chromatin	R-SMAD binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|ubiquitin-protein ligase activity			lung(4)|ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	9	Lung SC(675;0.225)													Wilms_tumor-Aniridia-ambiguous_Genitals-mental_Retardation				---	---	---	---
LDLRAD3	143458	broad.mit.edu	37	11	36103199	36103199	+	Intron	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:36103199G>A	uc001mwk.1	+						LDLRAD3_uc010rey.1_Intron|LDLRAD3_uc010rez.1_Intron	NM_174902	NP_777562			low density lipoprotein receptor class A domain							integral to membrane	receptor activity			central_nervous_system(1)	1	all_lung(20;0.089)|Lung NSC(22;0.175)|all_epithelial(35;0.177)	all_hematologic(20;0.124)																---	---	---	---
EXT2	2132	broad.mit.edu	37	11	44129758	44129758	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:44129758C>T	uc001mxz.2	+	2	830	c.496C>T	c.(496-498)CGC>TGC	p.R166C	EXT2_uc010rfo.1_Missense_Mutation_p.R194C|EXT2_uc001mxy.2_Missense_Mutation_p.R179C|EXT2_uc009ykt.2_Missense_Mutation_p.R166C|EXT2_uc001mya.2_Missense_Mutation_p.R199C	NM_207122	NP_997005	Q93063	EXT2_HUMAN	exostosin 2 isoform 2	166	Lumenal (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity			lung(2)|breast(2)|skin(1)	5								Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses				---	---	---	---
CHST1	8534	broad.mit.edu	37	11	45671728	45671728	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:45671728T>C	uc001mys.1	-	4	1417	c.746A>G	c.(745-747)GAC>GGC	p.D249G		NM_003654	NP_003645	O43916	CHST1_HUMAN	carbohydrate (keratan sulfate Gal-6)	249	Lumenal (Potential).				galactose metabolic process|inflammatory response|keratan sulfate metabolic process	Golgi membrane|integral to membrane	keratan sulfotransferase activity			skin(4)|pancreas(1)	5				GBM - Glioblastoma multiforme(35;3e-06)|BRCA - Breast invasive adenocarcinoma(625;0.0781)														---	---	---	---
AMBRA1	55626	broad.mit.edu	37	11	46419362	46419362	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:46419362C>T	uc010rgu.1	-	18	3895	c.3535G>A	c.(3535-3537)GGC>AGC	p.G1179S	AMBRA1_uc010rgt.1_3'UTR|AMBRA1_uc009ylc.1_Missense_Mutation_p.G1150S|AMBRA1_uc001ncu.1_Missense_Mutation_p.G1089S|AMBRA1_uc001ncv.2_Missense_Mutation_p.G1182S|AMBRA1_uc001ncw.2_Missense_Mutation_p.G1060S|AMBRA1_uc001ncx.2_Missense_Mutation_p.G1119S	NM_017749	NP_060219	Q9C0C7	AMRA1_HUMAN	activating molecule in beclin-1-regulated	1179					autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				large_intestine(1)|ovary(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)														---	---	---	---
KIAA0652	9776	broad.mit.edu	37	11	46690085	46690085	+	Missense_Mutation	SNP	T	C	C	rs141181676		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:46690085T>C	uc009yld.2	+	15	1873	c.1189T>C	c.(1189-1191)TTT>CTT	p.F397L	KIAA0652_uc001nda.2_Missense_Mutation_p.F430L|KIAA0652_uc001ndb.2_Missense_Mutation_p.F397L|KIAA0652_uc001ncz.2_Missense_Mutation_p.F360L|KIAA0652_uc001ndc.2_Missense_Mutation_p.F360L|KIAA0652_uc010rgv.1_Missense_Mutation_p.F281L	NM_001142673	NP_001136145	O75143	ATG13_HUMAN	autophagy-related protein 13 isoform 1	397					autophagic vacuole assembly	cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding				0				GBM - Glioblastoma multiforme(35;0.226)														---	---	---	---
F2	2147	broad.mit.edu	37	11	46744981	46744981	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:46744981C>T	uc001ndf.3	+	6	515	c.472C>T	c.(472-474)CGC>TGC	p.R158C	F2_uc001ndg.3_RNA	NM_000506	NP_000497	P00734	THRB_HUMAN	coagulation factor II preproprotein	158	Kringle 1.				activation of caspase activity|acute-phase response|blood coagulation, intrinsic pathway|cell surface receptor linked signaling pathway|cytosolic calcium ion homeostasis|fibrinolysis|leukocyte migration|negative regulation of astrocyte differentiation|negative regulation of fibrinolysis|negative regulation of platelet activation|negative regulation of proteolysis|peptidyl-glutamic acid carboxylation|platelet activation|positive regulation of collagen biosynthetic process|positive regulation of protein phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of release of sequestered calcium ion into cytosol|post-translational protein modification|proteolysis|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	cytosol|endoplasmic reticulum lumen|extracellular space|Golgi lumen|plasma membrane|soluble fraction	calcium ion binding|growth factor activity|serine-type endopeptidase activity|thrombospondin receptor activity			ovary(3)	3		all_lung(304;0.000414)|Lung NSC(402;0.0011)		BRCA - Breast invasive adenocarcinoma(625;0.146)	Antihemophilic Factor(DB00025)|Argatroban(DB00278)|Bivalirudin(DB00006)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)|Enoxaparin(DB01225)|Heparin(DB01109)|Lepirudin(DB00001)|Menadione(DB00170)|Proflavine(DB01123)|Simvastatin(DB00641)|Suramin(DB04786)|Warfarin(DB00682)|Ximelagatran(DB04898)													---	---	---	---
PSMC3	5702	broad.mit.edu	37	11	47445735	47445735	+	Splice_Site	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:47445735C>A	uc001nfh.2	-	6	648	c.454_splice	c.e6-1	p.G152_splice	PSMC3_uc009ylr.1_Splice_Site_p.G110_splice	NM_002804	NP_002795			proteasome 26S ATPase subunit 3						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|nucleoside-triphosphatase activity|protein binding|transcription coactivator activity|transcription corepressor activity			ovary(4)	4				Lung(87;0.0932)|BRCA - Breast invasive adenocarcinoma(625;0.13)														---	---	---	---
OR4C46	119749	broad.mit.edu	37	11	51515297	51515297	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:51515297A>G	uc010ric.1	+	1	16	c.16A>G	c.(16-18)AAC>GAC	p.N6D		NM_001004703	NP_001004703	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C,	6	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1																		---	---	---	---
TRIM48	79097	broad.mit.edu	37	11	55035844	55035844	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55035844T>C	uc010rid.1	+	4	660	c.574T>C	c.(574-576)TAC>CAC	p.Y192H		NM_024114	NP_077019	Q8IWZ4	TRI48_HUMAN	tripartite motif-containing 48	176						intracellular	zinc ion binding				0																		---	---	---	---
TRIM48	79097	broad.mit.edu	37	11	55035854	55035854	+	Intron	SNP	T	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55035854T>A	uc010rid.1	+							NM_024114	NP_077019			tripartite motif-containing 48							intracellular	zinc ion binding				0																		---	---	---	---
TRIM48	79097	broad.mit.edu	37	11	55035855	55035855	+	Intron	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55035855A>G	uc010rid.1	+							NM_024114	NP_077019			tripartite motif-containing 48							intracellular	zinc ion binding				0																		---	---	---	---
SPRYD5	84767	broad.mit.edu	37	11	55656478	55656478	+	Splice_Site	SNP	G	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55656478G>C	uc010rip.1	+	5	853	c.761_splice	c.e5+1	p.R254_splice	SPRYD5_uc010riq.1_Splice_Site_p.R111_splice	NM_032681	NP_116070			SPRY domain containing 5							intracellular	zinc ion binding				0		all_epithelial(135;0.226)																---	---	---	---
OR5J2	282775	broad.mit.edu	37	11	55944701	55944701	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55944701C>A	uc010rjb.1	+	1	608	c.608C>A	c.(607-609)TCC>TAC	p.S203Y		NM_001005492	NP_001005492	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J,	203	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|large_intestine(1)|breast(1)|pancreas(1)	4	Esophageal squamous(21;0.00693)																	---	---	---	---
OR5AP2	338675	broad.mit.edu	37	11	56409724	56409724	+	Silent	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:56409724G>T	uc001njb.1	-	1	192	c.192C>A	c.(190-192)CCC>CCA	p.P64P		NM_001002925	NP_001002925	Q8NGF4	O5AP2_HUMAN	olfactory receptor, family 5, subfamily AP,	64	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4																		---	---	---	---
APLNR	187	broad.mit.edu	37	11	57004323	57004323	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:57004323G>A	uc001njo.2	-	1	605	c.156C>T	c.(154-156)ACC>ACT	p.T52T	APLNR_uc001njn.3_RNA	NM_005161	NP_005152	P35414	APJ_HUMAN	apelin receptor	52	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity	p.T52N(1)		lung(5)|ovary(1)	6																		---	---	---	---
MS4A8B	83661	broad.mit.edu	37	11	60468386	60468386	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:60468386C>A	uc001npv.2	+	2	256	c.53C>A	c.(52-54)GCA>GAA	p.A18E	MS4A8B_uc009yne.1_Missense_Mutation_p.A18E	NM_031457	NP_113645	Q9BY19	M4A8B_HUMAN	membrane-spanning 4-domains, subfamily A, member	18	Cytoplasmic (Potential).					integral to membrane	receptor activity				0																		---	---	---	---
DAGLA	747	broad.mit.edu	37	11	61511425	61511425	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:61511425G>A	uc001nsa.2	+	20	2704	c.2593G>A	c.(2593-2595)GTC>ATC	p.V865I		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	neural stem cell-derived dendrite regulator	865	Cytoplasmic (Potential).				cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3				READ - Rectum adenocarcinoma(4;0.219)														---	---	---	---
INCENP	3619	broad.mit.edu	37	11	61897562	61897562	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:61897562C>A	uc001nsw.1	+	4	765	c.563C>A	c.(562-564)TCC>TAC	p.S188Y	INCENP_uc009ynv.2_Missense_Mutation_p.S188Y|INCENP_uc009ynw.1_Missense_Mutation_p.S188Y|INCENP_uc001nsx.1_Missense_Mutation_p.S188Y	NM_001040694	NP_001035784	Q9NQS7	INCE_HUMAN	inner centromere protein antigens 135/155kDa	188					chromosome segregation|cytokinesis|mitotic prometaphase	centromeric heterochromatin|condensed chromosome kinetochore|cytosol|microtubule|spindle	protein binding			lung(1)	1																		---	---	---	---
AHNAK	79026	broad.mit.edu	37	11	62289273	62289273	+	Missense_Mutation	SNP	G	T	T	rs147636421		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62289273G>T	uc001ntl.2	-	5	12916	c.12616C>A	c.(12616-12618)CCA>ACA	p.P4206T	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	4206					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)																---	---	---	---
HNRNPUL2	221092	broad.mit.edu	37	11	62482999	62482999	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62482999T>C	uc001nuw.2	-	13	2329	c.2136A>G	c.(2134-2136)AGA>AGG	p.R712R	HNRNPUL2_uc001nuu.1_RNA	NM_001079559	NP_001073027	Q1KMD3	HNRL2_HUMAN	heterogeneous nuclear ribonucleoprotein U-like	712	Tyr-rich.				cell killing	nucleus	ATP binding|nucleic acid binding				0																		---	---	---	---
SLC22A6	9356	broad.mit.edu	37	11	62748725	62748725	+	Intron	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62748725A>G	uc001nwk.2	-						SLC22A6_uc001nwl.2_Intron|SLC22A6_uc001nwj.2_Intron|SLC22A6_uc001nwm.2_Intron	NM_004790	NP_004781			solute carrier family 22 member 6 isoform a						alpha-ketoglutarate transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|protein binding				0																		---	---	---	---
NRXN2	9379	broad.mit.edu	37	11	64419616	64419616	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:64419616G>A	uc001oar.2	-	14	2866	c.2427C>T	c.(2425-2427)CCC>CCT	p.P809P	NRXN2_uc001oas.2_Silent_p.P769P|NRXN2_uc001oaq.2_Silent_p.P476P	NM_015080	NP_055895	P58401	NRX2B_HUMAN	neurexin 2 isoform alpha-1 precursor	170	Extracellular (Potential).|Laminin G-like.				cell adhesion	integral to membrane		p.P809P(1)		upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10																		---	---	---	---
MALAT1	378938	broad.mit.edu	37	11	65265646	65265646	+	RNA	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65265646C>T	uc010roh.1	+	1		c.414C>T				NR_002819				Homo sapiens clone alpha1 mRNA sequence.												0																		---	---	---	---
YIF1A	10897	broad.mit.edu	37	11	66053235	66053235	+	Intron	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66053235A>G	uc001ohk.3	-						YIF1A_uc001ohj.2_Intron	NM_020470	NP_065203			Yip1 interacting factor homolog						protein transport|vesicle-mediated transport	centrosome|endoplasmic reticulum membrane|ER-Golgi intermediate compartment|Golgi membrane|integral to membrane					0																		---	---	---	---
SPTBN2	6712	broad.mit.edu	37	11	66457628	66457628	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66457628C>T	uc001ojd.2	-	27	5764	c.5692G>A	c.(5692-5694)GCC>ACC	p.A1898T	SPTBN2_uc001ojc.1_5'Flank	NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	1898	Spectrin 15.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4																		---	---	---	---
LRFN4	78999	broad.mit.edu	37	11	66625774	66625774	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66625774G>A	uc001ojr.2	+	1	899	c.559G>A	c.(559-561)GGC>AGC	p.G187S	PC_uc001ojo.1_Intron|PC_uc001ojp.1_Intron|PC_uc001ojn.1_Intron|LRFN4_uc001ojq.1_Missense_Mutation_p.G187S|LRFN4_uc001ojs.2_Missense_Mutation_p.G187S	NM_024036	NP_076941	Q6PJG9	LRFN4_HUMAN	leucine rich repeat and fibronectin type III	187	Extracellular (Potential).|LRR 6.					integral to membrane					0																		---	---	---	---
ADRBK1	156	broad.mit.edu	37	11	67048958	67048958	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:67048958C>T	uc009yrn.1	+	9	942	c.676C>T	c.(676-678)CGC>TGC	p.R226C	ADRBK1_uc009yrm.1_Missense_Mutation_p.R226C	NM_001619	NP_001610	P25098	ARBK1_HUMAN	beta-adrenergic receptor kinase 1	226	Protein kinase.				activation of phospholipase C activity|cardiac muscle contraction|desensitization of G-protein coupled receptor protein signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of striated muscle contraction|negative regulation of the force of heart contraction by chemical signal|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of catecholamine secretion|tachykinin receptor signaling pathway	cytosol|soluble fraction	alpha-2A adrenergic receptor binding|ATP binding|beta-adrenergic receptor kinase activity|Edg-2 lysophosphatidic acid receptor binding|G-protein coupled receptor kinase activity|signal transducer activity			large_intestine(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)		Adenosine triphosphate(DB00171)													---	---	---	---
ADRBK1	156	broad.mit.edu	37	11	67051256	67051256	+	Intron	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:67051256C>T	uc009yrn.1	+						ADRBK1_uc009yrm.1_Intron	NM_001619	NP_001610			beta-adrenergic receptor kinase 1						activation of phospholipase C activity|cardiac muscle contraction|desensitization of G-protein coupled receptor protein signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of striated muscle contraction|negative regulation of the force of heart contraction by chemical signal|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of catecholamine secretion|tachykinin receptor signaling pathway	cytosol|soluble fraction	alpha-2A adrenergic receptor binding|ATP binding|beta-adrenergic receptor kinase activity|Edg-2 lysophosphatidic acid receptor binding|G-protein coupled receptor kinase activity|signal transducer activity			large_intestine(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)		Adenosine triphosphate(DB00171)													---	---	---	---
SUV420H1	51111	broad.mit.edu	37	11	67925991	67925991	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:67925991C>A	uc001onm.1	-	11	2078	c.1822G>T	c.(1822-1824)GGC>TGC	p.G608C	SUV420H1_uc009yse.1_Missense_Mutation_p.G194C|SUV420H1_uc001onn.1_Missense_Mutation_p.G436C|SUV420H1_uc009ysf.2_Missense_Mutation_p.G368C	NM_017635	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 isoform	608					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(2)|kidney(1)	3																		---	---	---	---
IGHMBP2	3508	broad.mit.edu	37	11	68707031	68707031	+	Silent	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:68707031C>A	uc001ook.1	+	15	2916	c.2814C>A	c.(2812-2814)GCC>GCA	p.A938A	IGHMBP2_uc001ool.1_Silent_p.A562A	NM_002180	NP_002171	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	938	AN1-type.				cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)															---	---	---	---
TPCN2	219931	broad.mit.edu	37	11	68852673	68852673	+	Intron	SNP	G	A	A	rs112524756		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:68852673G>A	uc001oos.2	+						TPCN2_uc010rqg.1_Intron|TPCN2_uc001oot.2_Intron	NM_139075	NP_620714			two pore segment channel 2						cellular calcium ion homeostasis|smooth muscle contraction	endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated calcium channel activity				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)															---	---	---	---
PPFIA1	8500	broad.mit.edu	37	11	70194330	70194330	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:70194330G>A	uc001opo.2	+	16	2165	c.1967G>A	c.(1966-1968)CGG>CAG	p.R656Q	PPFIA1_uc001opn.1_Missense_Mutation_p.R656Q|PPFIA1_uc001opp.2_RNA|PPFIA1_uc001opq.1_RNA	NM_003626	NP_003617	Q13136	LIPA1_HUMAN	PTPRF interacting protein alpha 1 isoform b	656	Potential.				cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)															---	---	---	---
NADSYN1	55191	broad.mit.edu	37	11	71201915	71201915	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:71201915C>T	uc001oqn.2	+	17	1713	c.1587C>T	c.(1585-1587)TAC>TAT	p.Y529Y	NADSYN1_uc001oqo.2_Silent_p.Y269Y|NADSYN1_uc001oqp.2_Silent_p.Y158Y	NM_018161	NP_060631	Q6IA69	NADE_HUMAN	NAD synthetase 1	529	Ligase (By similarity).				NAD biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|NAD+ synthase (glutamine-hydrolyzing) activity|protein binding			ovary(2)	2					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)													---	---	---	---
UCP2	7351	broad.mit.edu	37	11	73687680	73687680	+	Intron	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:73687680A>G	uc001oup.1	-						UCP2_uc001ouq.1_Intron	NM_003355	NP_003346			uncoupling protein 2						proton transport|respiratory electron transport chain	integral to membrane|mitochondrial inner membrane	binding				0	Breast(11;0.000112)																	---	---	---	---
WNT11	7481	broad.mit.edu	37	11	75898133	75898133	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:75898133G>A	uc001oxe.2	-	5	1164	c.1041C>T	c.(1039-1041)ACC>ACT	p.T347T		NM_004626	NP_004617	O96014	WNT11_HUMAN	wingless-type MMTV integration site family,	347					adrenal gland development|anterior/posterior pattern formation|artery morphogenesis|axis specification|bone mineralization|cellular response to retinoic acid|cloacal septation|embryonic skeletal system development|endoderm development|lung-associated mesenchyme development|mesonephric duct development|negative regulation of apoptosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cartilage development|negative regulation of cell growth|negative regulation of cell migration|negative regulation of transcription, DNA-dependent|neuroendocrine cell differentiation|neuron differentiation|osteoblast differentiation|outflow tract morphogenesis|palate development|positive regulation of cell migration|positive regulation of protein kinase C signaling cascade|positive regulation of stress fiber assembly|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor-beta2 production|protein localization at cell surface|protein phosphorylation|tight junction assembly|ureteric bud morphogenesis|ventricular septum morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|protein kinase activator activity|Ras GTPase activator activity|transcription regulatory region DNA binding			lung(1)|skin(1)	2																		---	---	---	---
ME3	10873	broad.mit.edu	37	11	86267648	86267648	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:86267648C>T	uc001pbz.2	-	3	668	c.414G>A	c.(412-414)ACG>ACA	p.T138T	ME3_uc001pca.2_Silent_p.T138T|ME3_uc009yvk.2_Silent_p.T138T|ME3_uc010rtr.1_RNA	NM_001014811	NP_001014811	Q16798	MAON_HUMAN	mitochondrial malic enzyme 3 precursor	138					aerobic respiration|malate metabolic process|oxygen metabolic process|pyruvate metabolic process	mitochondrial matrix	malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|metal ion binding|NAD binding			ovary(1)	1		Acute lymphoblastic leukemia(157;4.34e-06)|all_hematologic(158;0.00252)			NADH(DB00157)													---	---	---	---
GRM5	2915	broad.mit.edu	37	11	88386447	88386447	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:88386447G>A	uc001pcq.2	-	3	1236	c.1036C>T	c.(1036-1038)CCA>TCA	p.P346S	GRM5_uc009yvm.2_Missense_Mutation_p.P346S	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	346	Extracellular (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)													---	---	---	---
NOX4	50507	broad.mit.edu	37	11	89133259	89133259	+	Intron	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:89133259C>T	uc001pct.2	-						NOX4_uc009yvr.2_Intron|NOX4_uc001pcu.2_Intron|NOX4_uc001pcw.2_Intron|NOX4_uc001pcx.2_Intron|NOX4_uc001pcv.2_Intron|NOX4_uc009yvo.2_Intron|NOX4_uc010rtu.1_Intron|NOX4_uc009yvp.2_Intron|NOX4_uc010rtv.1_Intron|NOX4_uc009yvq.2_Intron	NM_016931	NP_058627			NADPH oxidase 4 isoform a						cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)																---	---	---	---
NAALAD2	10003	broad.mit.edu	37	11	89892496	89892496	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:89892496A>G	uc001pdf.3	+	8	1089	c.980A>G	c.(979-981)GAT>GGT	p.D327G	NAALAD2_uc009yvx.2_Intron|NAALAD2_uc009yvy.2_Intron|NAALAD2_uc001pdd.2_3'UTR|NAALAD2_uc001pde.2_Intron	NM_005467	NP_005458	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	327	Extracellular (Potential).|NAALADase.				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)																---	---	---	---
FAT3	120114	broad.mit.edu	37	11	92538325	92538325	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:92538325A>G	uc001pdj.3	+	10	8920	c.8903A>G	c.(8902-8904)AAC>AGC	p.N2968S		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2968	Cadherin 27.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)													TCGA Ovarian(4;0.039)			---	---	---	---
FAT3	120114	broad.mit.edu	37	11	92539641	92539641	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:92539641T>C	uc001pdj.3	+	11	9224	c.9207T>C	c.(9205-9207)TAT>TAC	p.Y3069Y		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	3069	Cadherin 28.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)													TCGA Ovarian(4;0.039)			---	---	---	---
PIWIL4	143689	broad.mit.edu	37	11	94353244	94353244	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:94353244C>T	uc001pfa.2	+	19	2587	c.2376C>T	c.(2374-2376)AAC>AAT	p.N792N	PIWIL4_uc009ywk.1_RNA	NM_152431	NP_689644	Q7Z3Z4	PIWL4_HUMAN	piwi-like 4	792	Piwi.				cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|meiosis|multicellular organismal development|piRNA metabolic process|regulation of translation|spermatogenesis	nucleus|piP-body	piRNA binding			skin(1)	1		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)																---	---	---	---
PGR	5241	broad.mit.edu	37	11	100998808	100998808	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:100998808C>T	uc001pgh.2	-	1	1737	c.994G>A	c.(994-996)GGG>AGG	p.G332R	PGR_uc001pgi.2_Missense_Mutation_p.G332R|PGR_uc009yww.1_RNA|PGR_uc001pgj.2_RNA|PGR_uc009ywx.1_RNA|uc010rum.1_5'Flank	NM_000926	NP_000917	P06401	PRGR_HUMAN	progesterone receptor	332	Modulating, Pro-Rich.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			lung(1)|liver(1)|central_nervous_system(1)|pancreas(1)	4		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)													---	---	---	---
MMP27	64066	broad.mit.edu	37	11	102562575	102562575	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:102562575C>A	uc001phd.1	-	10	1487	c.1464G>T	c.(1462-1464)AAG>AAT	p.K488N		NM_022122	NP_071405	Q9H306	MMP27_HUMAN	matrix metalloproteinase 27 precursor	488					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3	all_cancers(8;0.000843)|all_epithelial(12;0.00362)|Lung NSC(15;0.21)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0509)|Lung(13;0.0696)|LUSC - Lung squamous cell carcinoma(19;0.13)|all cancers(10;0.176)	BRCA - Breast invasive adenocarcinoma(274;0.0151)														---	---	---	---
MMP12	4321	broad.mit.edu	37	11	102738724	102738724	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:102738724G>A	uc001phk.2	-	6	747	c.702C>T	c.(700-702)GCC>GCT	p.A234A		NM_002426	NP_002417	P39900	MMP12_HUMAN	matrix metalloproteinase 12 preproprotein	234					positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)													---	---	---	---
DRD2	1813	broad.mit.edu	37	11	113287617	113287617	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:113287617G>A	uc001pnz.2	-	3	821	c.500C>T	c.(499-501)TCC>TTC	p.S167F	DRD2_uc010rwv.1_Missense_Mutation_p.S166F|DRD2_uc001poa.3_Missense_Mutation_p.S167F|DRD2_uc001pob.3_Missense_Mutation_p.S167F|DRD2_uc009yyr.1_Missense_Mutation_p.S167F	NM_000795	NP_000786	P14416	DRD2_HUMAN	dopamine receptor D2 isoform long	167	Helical; Name=4; (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			pancreas(1)|skin(1)	2		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)													---	---	---	---
APOA1	335	broad.mit.edu	37	11	116706810	116706810	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:116706810C>T	uc001ppu.1	-	4	597	c.518G>A	c.(517-519)CGC>CAC	p.R173H	APOA1_uc001ppv.1_Missense_Mutation_p.R173H	NM_000039	NP_000030	P02647	APOA1_HUMAN	apolipoprotein A-I preproprotein	173	6.|10 X approximate tandem repeats.				Cdc42 protein signal transduction|cholesterol efflux|cholesterol homeostasis|cholesterol import|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|negative regulation of cytokine secretion involved in immune response|negative regulation of interleukin-1 beta secretion|negative regulation of very-low-density lipoprotein particle remodeling|phosphatidylcholine biosynthetic process|phospholipid efflux|platelet activation|platelet degranulation|positive regulation of cholesterol esterification|positive regulation of hydrolase activity|protein stabilization|reverse cholesterol transport	endocytic vesicle|endoplasmic reticulum lumen|plasma membrane|spherical high-density lipoprotein particle|stored secretory granule|very-low-density lipoprotein particle	apolipoprotein A-I receptor binding|beta-amyloid binding|cholesterol binding|cholesterol transporter activity|enzyme binding|high-density lipoprotein particle receptor binding|identical protein binding|phosphatidylcholine-sterol O-acyltransferase activator activity|phospholipid binding				0	all_hematologic(175;0.0487)	Breast(348;0.0126)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|Epithelial(105;1.59e-05)|all cancers(92;0.000162)|OV - Ovarian serous cystadenocarcinoma(223;0.148)														---	---	---	---
DSCAML1	57453	broad.mit.edu	37	11	117389401	117389401	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:117389401C>T	uc001prh.1	-	7	1472	c.1470G>A	c.(1468-1470)GCG>GCA	p.A490A	DSCAML1_uc001pri.1_Silent_p.A294A	NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	430	Extracellular (Potential).|Ig-like C2-type 5.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)														---	---	---	---
AMICA1	120425	broad.mit.edu	37	11	118074193	118074193	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118074193A>T	uc001psk.2	-	6	896	c.722T>A	c.(721-723)CTG>CAG	p.L241Q	AMICA1_uc001psg.2_Missense_Mutation_p.L51Q|AMICA1_uc001psh.2_Missense_Mutation_p.L202Q|AMICA1_uc009yzw.1_RNA|AMICA1_uc001psi.2_Missense_Mutation_p.L231Q|AMICA1_uc001psj.2_Missense_Mutation_p.L230Q|AMICA1_uc010rxw.1_Missense_Mutation_p.L202Q|AMICA1_uc010rxx.1_Missense_Mutation_p.L241Q|AMICA1_uc001psl.1_Missense_Mutation_p.L197Q	NM_001098526	NP_001091996	Q86YT9	JAML1_HUMAN	adhesion molecule, interacts with CXADR antigen	241	Ig-like V-type 2.|Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	cell junction|integral to membrane				ovary(1)	1	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)														---	---	---	---
AMICA1	120425	broad.mit.edu	37	11	118074310	118074310	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118074310A>T	uc001psk.2	-	6	779	c.605T>A	c.(604-606)TTC>TAC	p.F202Y	AMICA1_uc001psg.2_Missense_Mutation_p.F12Y|AMICA1_uc001psh.2_Missense_Mutation_p.F163Y|AMICA1_uc009yzw.1_RNA|AMICA1_uc001psi.2_Missense_Mutation_p.F192Y|AMICA1_uc001psj.2_Missense_Mutation_p.F191Y|AMICA1_uc010rxw.1_Missense_Mutation_p.F163Y|AMICA1_uc010rxx.1_Missense_Mutation_p.F202Y|AMICA1_uc001psl.1_Missense_Mutation_p.F158Y	NM_001098526	NP_001091996	Q86YT9	JAML1_HUMAN	adhesion molecule, interacts with CXADR antigen	202	Ig-like V-type 2.|Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	cell junction|integral to membrane				ovary(1)	1	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)														---	---	---	---
CD3E	916	broad.mit.edu	37	11	118184512	118184512	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118184512T>C	uc001psq.3	+	7	699	c.443T>C	c.(442-444)GTT>GCT	p.V148A		NM_000733	NP_000724	P07766	CD3E_HUMAN	CD3E antigen, epsilon polypeptide precursor	148	Helical; (Potential).				G-protein coupled receptor protein signaling pathway|signal complex assembly|T cell costimulation|T cell receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway	external side of plasma membrane|integral to plasma membrane	protein heterodimerization activity|protein kinase binding|receptor signaling complex scaffold activity|receptor signaling protein activity|SH3 domain binding|T cell receptor binding|transmembrane receptor activity			ovary(2)	2	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.09e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0251)	Muromonab(DB00075)													---	---	---	---
MLL	4297	broad.mit.edu	37	11	118354898	118354898	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118354898G>A	uc001pta.2	+	9	4110	c.4087G>A	c.(4087-4089)GAA>AAA	p.E1363K	MLL_uc001ptb.2_Missense_Mutation_p.E1363K|MLL_uc001pte.1_RNA|MLL_uc009zab.1_Missense_Mutation_p.E64K	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1363		Breakpoint for translocation to form MLL- AF3P21 and MLL-CASC5 oncogenes.|Breakpoint for translocation to form MLL- CENPK oncogene.			apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)				T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								---	---	---	---
BCL9L	283149	broad.mit.edu	37	11	118771337	118771337	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118771337T>G	uc001pug.2	-	6	4080	c.3115A>C	c.(3115-3117)ATG>CTG	p.M1039L	BCL9L_uc009zal.2_Missense_Mutation_p.M1034L	NM_182557	NP_872363	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	1039	Pro-rich.				negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			ovary(1)|pancreas(1)	2	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)														---	---	---	---
OR8D4	338662	broad.mit.edu	37	11	123777411	123777411	+	Silent	SNP	C	T	T	rs150083489		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:123777411C>T	uc010saa.1	+	1	273	c.273C>T	c.(271-273)TCC>TCT	p.S91S		NM_001005197	NP_001005197	Q8NGM9	OR8D4_HUMAN	olfactory receptor, family 8, subfamily D,	91	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.93e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0409)														---	---	---	---
Unknown	0	broad.mit.edu	37	11	124120790	124120790	+	IGR	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:124120790A>G								OR8G2 (24480 upstream) : OR8D1 (58947 downstream)																																			---	---	---	---
STT3A	3703	broad.mit.edu	37	11	125478022	125478022	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:125478022C>T	uc001qcd.2	+	9	909	c.799C>T	c.(799-801)CAC>TAC	p.H267Y	STT3A_uc009zbm.2_Missense_Mutation_p.H267Y|STT3A_uc001qce.2_Missense_Mutation_p.H267Y|STT3A_uc010sbg.1_Missense_Mutation_p.H175Y|STT3A_uc009zbn.2_Missense_Mutation_p.H41Y	NM_152713	NP_689926	P46977	STT3A_HUMAN	integral membrane protein 1	267	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity				0	all_hematologic(175;0.228)	Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0919)|all_lung(97;0.0994)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0996)														---	---	---	---
PUS3	83480	broad.mit.edu	37	11	125765842	125765842	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:125765842C>T	uc001qcy.2	-	2	436	c.338G>A	c.(337-339)CGA>CAA	p.R113Q	HYLS1_uc009zbv.2_Intron|HYLS1_uc001qcx.3_Intron	NM_031307	NP_112597	Q9BZE2	PUS3_HUMAN	pseudouridylate synthase 3	113						nucleus	RNA binding			ovary(1)	1	all_hematologic(175;0.177)	Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.131)|all_lung(97;0.139)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.043)														---	---	---	---
PRDM10	56980	broad.mit.edu	37	11	129784663	129784663	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:129784663G>A	uc001qfm.2	-	18	3021	c.2789C>T	c.(2788-2790)TCG>TTG	p.S930L	PRDM10_uc001qfj.2_Missense_Mutation_p.S844L|PRDM10_uc001qfk.2_Missense_Mutation_p.S840L|PRDM10_uc001qfl.2_Missense_Mutation_p.S844L|PRDM10_uc010sbx.1_Missense_Mutation_p.S840L|PRDM10_uc001qfn.2_Missense_Mutation_p.S926L|PRDM10_uc009zcs.1_Missense_Mutation_p.S113L	NM_020228	NP_064613	Q9NQV6	PRD10_HUMAN	PR domain containing 10 isoform 1	930	Gln-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)														---	---	---	---
APLP2	334	broad.mit.edu	37	11	129993525	129993525	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:129993525C>T	uc010sby.1	+	7	1098	c.941C>T	c.(940-942)GCG>GTG	p.A314V	APLP2_uc001qfp.2_Missense_Mutation_p.A314V|APLP2_uc001qfq.2_Intron|APLP2_uc010sbz.1_Intron|APLP2_uc001qfr.2_Intron|APLP2_uc001qfs.2_Intron|APLP2_uc001qfv.2_Intron	NM_001642	NP_001633	Q06481	APLP2_HUMAN	amyloid beta (A4) precursor-like protein 2	314	BPTI/Kunitz inhibitor.|Extracellular (Potential).				G-protein coupled receptor protein signaling pathway	integral to membrane|nucleus|plasma membrane	DNA binding|identical protein binding|serine-type endopeptidase inhibitor activity			ovary(3)	3	all_hematologic(175;0.0429)	Breast(109;0.00586)|Lung NSC(97;0.00785)|all_lung(97;0.0154)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0197)|Lung(977;0.24)														---	---	---	---
SNX19	399979	broad.mit.edu	37	11	130784286	130784286	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:130784286T>C	uc001qgk.3	-	1	2097	c.1549A>G	c.(1549-1551)AGC>GGC	p.S517G	SNX19_uc010sce.1_Intron|SNX19_uc010scf.1_Intron|SNX19_uc010scg.1_Intron|SNX19_uc001qgl.3_Missense_Mutation_p.S517G|SNX19_uc009zcx.1_Intron	NM_014758	NP_055573	Q92543	SNX19_HUMAN	sorting nexin 19	517					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			ovary(2)|lung(2)	4	all_hematologic(175;0.0597)	Lung NSC(97;0.000272)|all_lung(97;0.000608)|Breast(109;0.000962)|all_neural(223;0.0298)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;0.0195)|Lung(977;0.233)														---	---	---	---
NCAPD3	23310	broad.mit.edu	37	11	134050984	134050984	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:134050984G>A	uc001qhd.1	-	20	3153	c.2547C>T	c.(2545-2547)GAC>GAT	p.D849D	NCAPD3_uc010scm.1_RNA|NCAPD3_uc009zda.1_RNA	NM_015261	NP_056076	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3	849					cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	5	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)														---	---	---	---
NCAPD3	23310	broad.mit.edu	37	11	134079287	134079287	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:134079287G>A	uc001qhd.1	-	5	1258	c.652C>T	c.(652-654)CAC>TAC	p.H218Y	NCAPD3_uc010scm.1_RNA|NCAPD3_uc009zda.1_RNA	NM_015261	NP_056076	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3	218					cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	5	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)														---	---	---	---
THYN1	29087	broad.mit.edu	37	11	134118831	134118831	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:134118831A>G	uc001qhf.2	-	7	605	c.503T>C	c.(502-504)ATG>ACG	p.M168T	THYN1_uc001qhg.2_Missense_Mutation_p.M168T|THYN1_uc001qhh.2_Missense_Mutation_p.M168T|THYN1_uc001qhi.2_Intron|THYN1_uc001qhj.2_Intron	NM_001037305	NP_001032382	Q9P016	THYN1_HUMAN	thymocyte nuclear protein 1 isoform 1	168						nucleus					0	all_hematologic(175;0.127)	all_cancers(12;1.1e-21)|all_epithelial(12;3.77e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;1.68e-10)|all cancers(11;1.95e-09)|BRCA - Breast invasive adenocarcinoma(10;8.45e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00148)|Lung(977;0.207)														---	---	---	---
IQSEC3	440073	broad.mit.edu	37	12	248074	248074	+	Silent	SNP	G	A	A	rs138206814	byFrequency	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:248074G>A	uc001qhw.1	+	1	642	c.636G>A	c.(634-636)ACG>ACA	p.T212T	IQSEC3_uc001qhu.1_Silent_p.T212T|IQSEC3_uc001qht.1_Silent_p.T297T|uc001qhv.1_Intron	NM_015232	NP_056047	Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	515					regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)														---	---	---	---
EFCAB4B	84766	broad.mit.edu	37	12	3757704	3757704	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:3757704G>A	uc001qmj.2	-	11	1694	c.1122C>T	c.(1120-1122)TGC>TGT	p.C374C	EFCAB4B_uc010sen.1_Intron|EFCAB4B_uc010seo.1_Intron|EFCAB4B_uc001qmi.1_RNA	NM_032680	NP_116069	Q9BSW2	EFC4B_HUMAN	EF-hand calcium binding domain 4B isoform c	374					activation of store-operated calcium channel activity|store-operated calcium entry	cytoplasm	calcium ion binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(31;0.00287)|COAD - Colon adenocarcinoma(12;0.0264)															---	---	---	---
PLEKHG6	55200	broad.mit.edu	37	12	6424299	6424299	+	Silent	SNP	C	T	T	rs143574959		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:6424299C>T	uc001qnr.2	+	4	571	c.423C>T	c.(421-423)ATC>ATT	p.I141I	PLEKHG6_uc001qns.2_Silent_p.I141I|PLEKHG6_uc010sew.1_Silent_p.I141I|PLEKHG6_uc010sex.1_Silent_p.I109I	NM_018173	NP_060643	Q3KR16	PKHG6_HUMAN	pleckstrin homology domain-containing family G	141					regulation of Rho protein signal transduction	cleavage furrow|cytoplasm|spindle pole	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity	p.I141I(1)		large_intestine(1)|skin(1)	2																		---	---	---	---
IFFO1	25900	broad.mit.edu	37	12	6660095	6660095	+	Intron	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:6660095C>T	uc001qpd.1	-						IFFO1_uc001qoy.2_Intron|IFFO1_uc001qpa.1_5'Flank|IFFO1_uc001qpb.1_5'Flank|IFFO1_uc001qpe.1_Intron|IFFO1_uc010sfe.1_Intron|IFFO1_uc001qpf.1_Intron|IFFO1_uc001qoz.1_5'Flank|IFFO1_uc001qpc.1_Intron|IFFO1_uc001qpg.2_5'Flank	NM_080730	NP_542768			intermediate filament family orphan isoform 2							intermediate filament					0																		---	---	---	---
CD4	920	broad.mit.edu	37	12	6926429	6926429	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:6926429T>C	uc001qqv.1	+	7	1334	c.1089T>C	c.(1087-1089)CCT>CCC	p.P363P	CD4_uc010sfj.1_Silent_p.P90P|CD4_uc009zfc.1_Silent_p.P184P|CD4_uc010sfk.1_Silent_p.P90P|CD4_uc010sfl.1_Silent_p.P90P|CD4_uc010sfm.1_Silent_p.P90P	NM_000616	NP_000607	P01730	CD4_HUMAN	CD4 antigen precursor	363	Ig-like C2-type 3.|Extracellular (Potential).				cell adhesion|entry into host cell|immune response|induction by virus of host cell-cell fusion|initiation of viral infection|maintenance of protein location in cell|positive regulation of interleukin-2 biosynthetic process|positive regulation of protein kinase activity|protein palmitoleylation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|T cell selection|transmembrane receptor protein tyrosine kinase signaling pathway	early endosome|endoplasmic reticulum membrane|integral to membrane|T cell receptor complex	coreceptor activity|extracellular matrix structural constituent|glycoprotein binding|MHC class II protein binding|protein homodimerization activity|protein kinase binding|transmembrane receptor activity|zinc ion binding				0		Myeloproliferative disorder(1001;0.0122)																---	---	---	---
CD163	9332	broad.mit.edu	37	12	7651478	7651478	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:7651478C>A	uc001qsz.3	-	4	892	c.764G>T	c.(763-765)GGA>GTA	p.G255V	CD163_uc001qta.3_Missense_Mutation_p.G255V|CD163_uc009zfw.2_Missense_Mutation_p.G255V	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	255	SRCR 2.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8																		---	---	---	---
NECAP1	25977	broad.mit.edu	37	12	8244354	8244354	+	Intron	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:8244354G>A	uc001qtx.2	+						NECAP1_uc001qty.2_Intron	NM_015509	NP_056324			NECAP endocytosis associated 1						endocytosis|protein transport	clathrin coated vesicle membrane|plasma membrane				ovary(1)	1				Kidney(36;0.0915)														---	---	---	---
MFAP5	8076	broad.mit.edu	37	12	8807086	8807086	+	Intron	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:8807086G>A	uc001qut.1	-						MFAP5_uc001qus.2_Intron|MFAP5_uc009zge.1_Intron	NM_003480	NP_003471			microfibrillar associated protein 5 precursor							microfibril	extracellular matrix structural constituent			breast(1)	1	Lung SC(5;0.184)																	---	---	---	---
A2ML1	144568	broad.mit.edu	37	12	9020604	9020604	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:9020604C>A	uc001quz.3	+	30	3982	c.3884C>A	c.(3883-3885)CCT>CAT	p.P1295H	A2ML1_uc001qva.1_Missense_Mutation_p.P875H|A2ML1_uc010sgm.1_Missense_Mutation_p.P795H|A2ML1_uc001qvb.1_RNA	NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	1139						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3																		---	---	---	---
GABARAPL1	23710	broad.mit.edu	37	12	10373153	10373153	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:10373153A>G	uc001qxs.2	+	3	524	c.284A>G	c.(283-285)TAT>TGT	p.Y95C	GABARAPL1_uc010shb.1_Missense_Mutation_p.Y95C|GABARAPL1_uc001qxt.2_RNA|GABARAPL1_uc001qxu.2_RNA	NM_031412	NP_113600	Q9H0R8	GBRL1_HUMAN	GABA(A) receptor-associated protein like 1	95						autophagic vacuole|endoplasmic reticulum|Golgi apparatus|membrane|microtubule	beta-tubulin binding|GABA receptor binding				0																		---	---	---	---
KLRC1	3821	broad.mit.edu	37	12	10601870	10601870	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:10601870G>T	uc001qyl.2	-	5	619	c.455C>A	c.(454-456)TCC>TAC	p.S152Y	KLRC1_uc009zhm.1_Missense_Mutation_p.S152Y|KLRC1_uc001qym.2_Missense_Mutation_p.S134Y|KLRC1_uc001qyn.2_Missense_Mutation_p.S152Y|KLRC1_uc001qyo.2_Missense_Mutation_p.S134Y	NM_002259	NP_002250	P26715	NKG2A_HUMAN	killer cell lectin-like receptor subfamily C,	152	C-type lectin.|Extracellular (Potential).				cell surface receptor linked signaling pathway|regulation of immune response	integral to plasma membrane	sugar binding|transmembrane receptor activity				0																		---	---	---	---
TAS2R43	259289	broad.mit.edu	37	12	11244407	11244407	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:11244407G>A	uc001qzq.1	-	1	506	c.422C>T	c.(421-423)GCT>GTT	p.A141V	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176884	NP_795365	P59537	T2R43_HUMAN	taste receptor, type 2, member 43	141	Helical; Name=4; (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste	cilium membrane|motile cilium	bitter taste receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.0344)	BRCA - Breast invasive adenocarcinoma(232;0.196)														---	---	---	---
ATF7IP	55729	broad.mit.edu	37	12	14650878	14650878	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:14650878T>C	uc001rbw.2	+	15	3842	c.3684T>C	c.(3682-3684)TGT>TGC	p.C1228C	ATF7IP_uc001rbx.2_Silent_p.C1227C|ATF7IP_uc001rby.3_Silent_p.C1228C|ATF7IP_uc001rca.2_Silent_p.C1228C	NM_018179	NP_060649	Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting	1228	Interaction with MBD1.|Fibronectin type-III.				DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			lung(3)|ovary(1)|skin(1)	5																		---	---	---	---
KIAA0528	9847	broad.mit.edu	37	12	22631335	22631335	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:22631335C>T	uc001rfq.2	-	15	2042	c.1814G>A	c.(1813-1815)GGC>GAC	p.G605D	KIAA0528_uc010sir.1_Missense_Mutation_p.G420D|KIAA0528_uc010sis.1_Missense_Mutation_p.G605D|KIAA0528_uc010sit.1_Missense_Mutation_p.G607D|KIAA0528_uc010siu.1_Missense_Mutation_p.G605D|KIAA0528_uc001rfr.2_Missense_Mutation_p.G596D|KIAA0528_uc009ziy.1_Missense_Mutation_p.G607D	NM_014802	NP_055617	Q86YS7	K0528_HUMAN	hypothetical protein LOC9847	605							protein binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4																		---	---	---	---
LRMP	4033	broad.mit.edu	37	12	25232195	25232195	+	Silent	SNP	C	T	T	rs114104872	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:25232195C>T	uc001rgh.2	+	6	1076	c.42C>T	c.(40-42)CGC>CGT	p.R14R	LRMP_uc001rgg.1_RNA|LRMP_uc010sja.1_Silent_p.R14R|LRMP_uc010sjb.1_5'UTR|LRMP_uc001rgi.2_RNA|LRMP_uc010sjc.1_Silent_p.R14R|LRMP_uc010sjd.1_5'UTR	NM_006152	NP_006143	Q12912	LRMP_HUMAN	lymphoid-restricted membrane protein	70	Cytoplasmic (Potential).				vesicle fusion|vesicle targeting	endoplasmic reticulum membrane|integral to plasma membrane				ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Colorectal(261;0.11)																	---	---	---	---
PPFIBP1	8496	broad.mit.edu	37	12	27820253	27820253	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:27820253G>T	uc001ric.1	+	13	1574	c.1197G>T	c.(1195-1197)GAG>GAT	p.E399D	PPFIBP1_uc010sjr.1_Missense_Mutation_p.E230D|PPFIBP1_uc001rib.1_Missense_Mutation_p.E382D|PPFIBP1_uc001ria.2_Missense_Mutation_p.E368D|PPFIBP1_uc001rid.1_Missense_Mutation_p.E246D	NM_003622	NP_003613	Q86W92	LIPB1_HUMAN	PTPRF interacting protein binding protein 1	399	Potential.				cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	soft_tissue(3)|kidney(1)|skin(1)	5	Lung SC(9;0.0873)																	---	---	---	---
KIF21A	55605	broad.mit.edu	37	12	39763645	39763645	+	Silent	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:39763645A>G	uc001rly.2	-	3	482	c.336T>C	c.(334-336)GGT>GGC	p.G112G	KIF21A_uc001rlx.2_Silent_p.G112G|KIF21A_uc001rlz.2_Silent_p.G112G|KIF21A_uc010skl.1_Silent_p.G112G|KIF21A_uc001rma.1_Silent_p.G112G	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	112	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)																---	---	---	---
CNTN1	1272	broad.mit.edu	37	12	41408095	41408095	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:41408095T>C	uc001rmm.1	+	18	2292	c.2179T>C	c.(2179-2181)TGG>CGG	p.W727R	CNTN1_uc001rmn.1_Missense_Mutation_p.W716R	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	727	Fibronectin type-III 2.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)																---	---	---	---
PDZRN4	29951	broad.mit.edu	37	12	41967474	41967474	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:41967474C>T	uc010skn.1	+	10	2364	c.2296C>T	c.(2296-2298)CGA>TGA	p.R766*	PDZRN4_uc001rmq.3_Nonsense_Mutation_p.R707*|PDZRN4_uc009zjz.2_Nonsense_Mutation_p.R705*|PDZRN4_uc001rmr.2_Nonsense_Mutation_p.R592*	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	965							ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)																---	---	---	---
PPHLN1	51535	broad.mit.edu	37	12	42835202	42835202	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:42835202T>A	uc001rng.1	+	10	1100	c.995T>A	c.(994-996)TTT>TAT	p.F332Y	PPHLN1_uc001rmy.2_Missense_Mutation_p.F350Y|PPHLN1_uc001rne.2_Missense_Mutation_p.F320Y|PPHLN1_uc001rnb.2_Missense_Mutation_p.F339Y|PPHLN1_uc001rnd.2_Missense_Mutation_p.F284Y|PPHLN1_uc001rnc.2_Missense_Mutation_p.F332Y|PPHLN1_uc001rnf.2_Missense_Mutation_p.F313Y|PPHLN1_uc010skq.1_Missense_Mutation_p.F258Y|PPHLN1_uc010skr.1_Missense_Mutation_p.F277Y|PPHLN1_uc010sks.1_Missense_Mutation_p.F258Y|PPHLN1_uc010skt.1_Missense_Mutation_p.F212Y|PPHLN1_uc001rni.1_Missense_Mutation_p.F277Y|PPHLN1_uc001rnh.1_RNA|PPHLN1_uc010sku.1_Missense_Mutation_p.F265Y	NM_016488	NP_057572	Q8NEY8	PPHLN_HUMAN	periphilin 1 isoform 1	332					keratinization	cytoplasm|nucleus				ovary(1)|breast(1)	2	all_cancers(12;0.00049)|Breast(8;0.165)	Lung NSC(34;0.123)		GBM - Glioblastoma multiforme(48;0.0875)														---	---	---	---
ANO6	196527	broad.mit.edu	37	12	45784262	45784262	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:45784262C>T	uc001roo.2	+	12	1702	c.1367C>T	c.(1366-1368)GCC>GTC	p.A456V	ANO6_uc010sld.1_Missense_Mutation_p.A456V|ANO6_uc010sle.1_Missense_Mutation_p.A456V|ANO6_uc010slf.1_Missense_Mutation_p.A477V|ANO6_uc010slg.1_Missense_Mutation_p.A438V	NM_001025356	NP_001020527	Q4KMQ2	ANO6_HUMAN	anoctamin 6 isoform a	456	Helical; (Potential).				activation of blood coagulation via clotting cascade|phosphatidylserine exposure on blood platelet	chloride channel complex|plasma membrane	chloride channel activity			ovary(1)|kidney(1)	2																		---	---	---	---
C12orf41	54934	broad.mit.edu	37	12	49048764	49048764	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49048764T>C	uc001rrx.2	-	9	1382	c.1307A>G	c.(1306-1308)CAT>CGT	p.H436R	C12orf41_uc001rrw.2_Missense_Mutation_p.H207R|C12orf41_uc001rrz.2_Missense_Mutation_p.H619R|C12orf41_uc001rry.2_RNA|C12orf41_uc001rru.2_Missense_Mutation_p.H67R|C12orf41_uc001rrv.2_Missense_Mutation_p.H120R|SNORA34_uc001rsa.1_5'Flank|MIR1291_hsa-mir-1291|MI0006353_5'Flank	NM_017822	NP_060292	Q9H9L4	CL041_HUMAN	hypothetical protein LOC54934	436										ovary(2)	2																		---	---	---	---
ADCY6	112	broad.mit.edu	37	12	49169835	49169835	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49169835G>A	uc001rsh.3	-	8	2377	c.1717C>T	c.(1717-1719)CGG>TGG	p.R573W	ADCY6_uc001rsj.3_Missense_Mutation_p.R573W|ADCY6_uc001rsi.3_Missense_Mutation_p.R573W|ADCY6_uc010slw.1_5'Flank	NM_015270	NP_056085	O43306	ADCY6_HUMAN	adenylate cyclase 6 isoform a	573	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding				0																		---	---	---	---
DDX23	9416	broad.mit.edu	37	12	49230468	49230468	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49230468G>A	uc001rsm.2	-	10	1211	c.1120C>T	c.(1120-1122)CGT>TGT	p.R374C		NM_004818	NP_004809	Q9BUQ8	DDX23_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23	374						catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent RNA helicase activity|nucleic acid binding|protein binding	p.R374C(1)		kidney(3)|ovary(1)|lung(1)|skin(1)	6																		---	---	---	---
MLL2	8085	broad.mit.edu	37	12	49425937	49425937	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49425937C>T	uc001rta.3	-	39	12551	c.12551G>A	c.(12550-12552)GGT>GAT	p.G4184D		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	4184	Gln-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41								N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			---	---	---	---
MLL2	8085	broad.mit.edu	37	12	49435088	49435088	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49435088C>T	uc001rta.3	-	31	6465	c.6465G>A	c.(6463-6465)TCG>TCA	p.S2155S		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2155	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41								N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			---	---	---	---
DIP2B	57609	broad.mit.edu	37	12	51112539	51112539	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:51112539C>T	uc001rwv.2	+	24	3055	c.2899C>T	c.(2899-2901)CGT>TGT	p.R967C	DIP2B_uc009zlt.2_Missense_Mutation_p.R397C	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	967						nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6																		---	---	---	---
KRT18	3875	broad.mit.edu	37	12	53344642	53344642	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:53344642C>T	uc001sbe.2	+	4	678	c.609C>T	c.(607-609)ATC>ATT	p.I203I	KRT18_uc009zmn.1_Silent_p.I203I|KRT18_uc001sbf.1_Silent_p.I30I|KRT18_uc001sbg.2_Silent_p.I203I|KRT18_uc009zmo.2_Silent_p.I203I|KRT8_uc009zml.1_5'Flank|KRT8_uc009zmm.1_5'Flank	NM_199187	NP_954657	P05783	K1C18_HUMAN	keratin 18	203	Coil 1B.|Rod.|Necessary for interaction with PNN.				anatomical structure morphogenesis|cell cycle|Golgi to plasma membrane CFTR protein transport|interspecies interaction between organisms|negative regulation of apoptosis	centriolar satellite|keratin filament|perinuclear region of cytoplasm	protein binding|structural molecule activity			skin(1)	1																		---	---	---	---
ESPL1	9700	broad.mit.edu	37	12	53679780	53679780	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:53679780A>G	uc001sck.2	+	18	3351	c.3260A>G	c.(3259-3261)CAG>CGG	p.Q1087R	ESPL1_uc001scj.2_Missense_Mutation_p.Q762R|ESPL1_uc010soe.1_Intron	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	1087					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3																		---	---	---	---
ESPL1	9700	broad.mit.edu	37	12	53686642	53686642	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:53686642C>T	uc001sck.2	+	30	6140	c.6049C>T	c.(6049-6051)CGG>TGG	p.R2017W	ESPL1_uc001scj.2_Missense_Mutation_p.R1692W|PFDN5_uc001scl.2_5'Flank|PFDN5_uc001scm.2_5'Flank|PFDN5_uc001scn.2_5'Flank|PFDN5_uc001sco.2_5'Flank	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	2017					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3																		---	---	---	---
ERBB3	2065	broad.mit.edu	37	12	56482369	56482369	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56482369C>A	uc001sjh.2	+	8	1110	c.917C>A	c.(916-918)CCT>CAT	p.P306H	ERBB3_uc009zoj.2_RNA|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Missense_Mutation_p.P247H|ERBB3_uc001sji.2_5'UTR	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	306	Extracellular (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)															---	---	---	---
GLS2	27165	broad.mit.edu	37	12	56868375	56868375	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56868375T>C	uc001slj.2	-	12	1456	c.1177A>G	c.(1177-1179)ATG>GTG	p.M393V	GLS2_uc009zos.2_RNA|GLS2_uc001slk.2_Missense_Mutation_p.M128V|GLS2_uc009zot.2_Missense_Mutation_p.M54V	NM_013267	NP_037399	Q9UI32	GLSL_HUMAN	glutaminase 2 precursor	393					cellular amino acid biosynthetic process|glutamate secretion|glutamine metabolic process|neurotransmitter secretion	mitochondrial matrix	glutaminase activity|protein binding			ovary(1)|central_nervous_system(1)	2					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)													---	---	---	---
ATP5B	506	broad.mit.edu	37	12	57036610	57036610	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57036610C>T	uc001slr.2	-	6	903	c.798G>A	c.(796-798)GCG>GCA	p.A266A		NM_001686	NP_001677	P06576	ATPB_HUMAN	mitochondrial ATP synthase beta subunit	266					angiogenesis|ATP hydrolysis coupled proton transport|regulation of intracellular pH|respiratory electron transport chain	cell surface|mitochondrial nucleoid|mitochondrial proton-transporting ATP synthase, catalytic core|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|hydrogen-exporting ATPase activity, phosphorylative mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism			ovary(1)	1																		---	---	---	---
NACA	4666	broad.mit.edu	37	12	57114912	57114912	+	Intron	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57114912T>C	uc001slz.2	-						NACA_uc001sly.2_Intron|NACA_uc009zoy.1_Silent_p.S134S|NACA_uc001smc.2_Intron|NACA_uc001sma.2_Silent_p.S134S|NACA_uc001smb.2_Intron|NACA_uc010squ.1_Intron	NM_001113201	NP_001106672			nascent polypeptide-associated complex alpha						interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			ovary(1)	1								T	BCL6	NHL								---	---	---	---
TAC3	6866	broad.mit.edu	37	12	57406624	57406624	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57406624T>C	uc001smp.2	-	5	434	c.274A>G	c.(274-276)AAG>GAG	p.K92E	TAC3_uc001smr.2_RNA|TAC3_uc001smq.2_RNA|TAC3_uc001smt.2_RNA|TAC3_uc001sms.2_RNA|TAC3_uc010sqy.1_RNA|TAC3_uc001smu.2_Intron|TAC3_uc001smv.2_Intron|TAC3_uc001smo.2_Intron	NM_013251	NP_037383	Q9UHF0	TKNK_HUMAN	tachykinin 3 precursor	92					female pregnancy|neuropeptide signaling pathway|tachykinin receptor signaling pathway	extracellular space|soluble fraction	receptor binding			ovary(1)|skin(1)	2																		---	---	---	---
MYO1A	4640	broad.mit.edu	37	12	57432281	57432281	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57432281G>A	uc001smw.3	-	17	1918	c.1675C>T	c.(1675-1677)CGC>TGC	p.R559C	MYO1A_uc010sqz.1_Missense_Mutation_p.R397C|MYO1A_uc009zpd.2_Missense_Mutation_p.R559C	NM_005379	NP_005370	Q9UBC5	MYO1A_HUMAN	myosin IA	559	Myosin head-like.				sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|urinary_tract(1)	7																		---	---	---	---
GLI1	2735	broad.mit.edu	37	12	57861144	57861144	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57861144G>A	uc001snx.2	+	9	1019	c.941G>A	c.(940-942)CGC>CAC	p.R314H	GLI1_uc009zpq.2_Missense_Mutation_p.R186H	NM_005269	NP_005260	P08151	GLI1_HUMAN	GLI family zinc finger 1 isoform 1	314	C2H2-type 3.				epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			skin(4)|ovary(4)|breast(3)|central_nervous_system(1)|urinary_tract(1)|kidney(1)|pancreas(1)	15			GBM - Glioblastoma multiforme(3;3.99e-32)															---	---	---	---
GEFT	115557	broad.mit.edu	37	12	58006732	58006732	+	Silent	SNP	C	A	A	rs147842061		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:58006732C>A	uc001spb.2	+	2	577	c.117C>A	c.(115-117)GGC>GGA	p.G39G	GEFT_uc009zpy.2_Silent_p.G78G|GEFT_uc001soz.1_Intron|GEFT_uc001spa.2_Intron|uc001spc.2_RNA|GEFT_uc001spd.2_5'Flank	NM_182947	NP_891992	Q86VW2	ARHGP_HUMAN	RhoA/RAC/CDC42 exchange factor isoform 1	39					regulation of Rho protein signal transduction	cytosol|plasma membrane|sarcomere	Rho guanyl-nucleotide exchange factor activity				0	Melanoma(17;0.122)																	---	---	---	---
XPOT	11260	broad.mit.edu	37	12	64812808	64812808	+	Silent	SNP	C	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:64812808C>G	uc001ssb.2	+	6	849	c.423C>G	c.(421-423)CTC>CTG	p.L141L	XPOT_uc009zqm.1_Silent_p.L51L	NM_007235	NP_009166	O43592	XPOT_HUMAN	tRNA exportin	141	Necessary for interaction with Ran, nuclear localization and nuclear import.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(28;0.0404)														---	---	---	---
GNS	2799	broad.mit.edu	37	12	65113930	65113930	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:65113930G>A	uc001ssg.3	-	13	1622	c.1452C>T	c.(1450-1452)GAC>GAT	p.D484D	GNS_uc001ssf.2_Silent_p.D428D|GNS_uc010ssq.1_Silent_p.D516D|GNS_uc010ssr.1_Silent_p.D464D	NM_002076	NP_002067	P15586	GNS_HUMAN	glucosamine (N-acetyl)-6-sulfatase precursor	484						lysosome	metal ion binding|N-acetylglucosamine-6-sulfatase activity|protein binding			central_nervous_system(1)	1	Lung NSC(1;7.25e-14)|all_lung(1;1.25e-12)		LUAD - Lung adenocarcinoma(6;0.115)	GBM - Glioblastoma multiforme(28;0.0435)														---	---	---	---
MDM1	56890	broad.mit.edu	37	12	68709980	68709980	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:68709980C>T	uc001stz.2	-	8	1195	c.1059G>A	c.(1057-1059)ACG>ACA	p.T353T	MDM1_uc010stc.1_Silent_p.T318T|MDM1_uc009zqv.1_Silent_p.T73T	NM_017440	NP_059136	Q8TC05	MDM1_HUMAN	mouse Mdm1 nuclear protein homolog isoform 1	353						nucleus				ovary(3)|skin(2)	5			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000174)														---	---	---	---
KCNC2	3747	broad.mit.edu	37	12	75601374	75601374	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:75601374G>A	uc001sxg.1	-	2	934	c.390C>T	c.(388-390)TGC>TGT	p.C130C	KCNC2_uc009zry.2_Silent_p.C130C|KCNC2_uc001sxe.2_Silent_p.C130C|KCNC2_uc001sxf.2_Silent_p.C130C|KCNC2_uc010stw.1_Silent_p.C130C	NM_139137	NP_631875	Q96PR1	KCNC2_HUMAN	Shaw-related voltage-gated potassium channel	130	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(2)|pancreas(2)|skin(1)|lung(1)	6																		---	---	---	---
CSRP2	1466	broad.mit.edu	37	12	77254062	77254062	+	Splice_Site	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:77254062A>G	uc001syl.1	-	4	494	c.411_splice	c.e4+1	p.K137_splice		NM_001321	NP_001312			cysteine and glycine-rich protein 2						multicellular organismal development	nucleus	zinc ion binding			ovary(1)	1																		---	---	---	---
NAV3	89795	broad.mit.edu	37	12	78553055	78553055	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:78553055G>T	uc001syp.2	+	23	5031	c.4858G>T	c.(4858-4860)GCG>TCG	p.A1620S	NAV3_uc001syo.2_Missense_Mutation_p.A1620S|NAV3_uc010sub.1_Missense_Mutation_p.A1106S|NAV3_uc009zsf.2_Missense_Mutation_p.A451S	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1620	Potential.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17															HNSCC(70;0.22)			---	---	---	---
LRRIQ1	84125	broad.mit.edu	37	12	85518280	85518280	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:85518280T>C	uc001tac.2	+	17	4101	c.3990T>C	c.(3988-3990)ATT>ATC	p.I1330I	LRRIQ1_uc001tab.1_Silent_p.I1330I	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1330										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)														---	---	---	---
EPYC	1833	broad.mit.edu	37	12	91371989	91371989	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:91371989T>C	uc001tbk.2	-	3	309	c.216A>G	c.(214-216)CCA>CCG	p.P72P		NM_004950	NP_004941	Q99645	EPYC_HUMAN	dermatan sulfate proteoglycan 3 precursor	72					female pregnancy	proteinaceous extracellular matrix	glycosaminoglycan binding			skin(1)	1																OREG0022019	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
GOLGA2B	55592	broad.mit.edu	37	12	100551322	100551322	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:100551322G>A	uc001tgs.2	-	4	718	c.274C>T	c.(274-276)CCA>TCA	p.P92S	GOLGA2B_uc001tgt.2_RNA|GOLGA2B_uc001tgu.2_Missense_Mutation_p.P92S|uc001tgx.2_5'Flank	NM_017600	NP_060070			golgi autoantigen, golgin subfamily a, 2-like 1												0																		---	---	---	---
C12orf45	121053	broad.mit.edu	37	12	105388388	105388388	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:105388388A>G	uc001tlb.2	+	4	505	c.472A>G	c.(472-474)ATA>GTA	p.I158V		NM_152318	NP_689531	Q8N5I9	CL045_HUMAN	hypothetical protein LOC121053	158											0																		---	---	---	---
NUAK1	9891	broad.mit.edu	37	12	106460846	106460846	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:106460846C>T	uc001tlj.1	-	7	3100	c.1720G>A	c.(1720-1722)GAT>AAT	p.D574N		NM_014840	NP_055655	O60285	NUAK1_HUMAN	AMPK-related protein kinase 5	574							ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
ASCL4	121549	broad.mit.edu	37	12	108169061	108169061	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:108169061C>T	uc001tmr.2	+	1	900	c.69C>T	c.(67-69)GGC>GGT	p.G23G		NM_203436	NP_982260	Q6XD76	ASCL4_HUMAN	achaete-scute complex-like 4	22					regulation of transcription from RNA polymerase II promoter|skin development|transcription, DNA-dependent	nucleus	DNA binding			central_nervous_system(1)	1																		---	---	---	---
ACAD10	80724	broad.mit.edu	37	12	112167624	112167624	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:112167624C>T	uc001tsq.2	+	10	1458	c.1258C>T	c.(1258-1260)CGC>TGC	p.R420C	ACAD10_uc001tsp.2_Missense_Mutation_p.R420C|ACAD10_uc009zvx.2_Missense_Mutation_p.R451C|ACAD10_uc001tss.1_RNA	NM_025247	NP_079523	Q6JQN1	ACD10_HUMAN	acyl-Coenzyme A dehydrogenase family, member 10	420							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			ovary(2)	2																		---	---	---	---
RPL6	6128	broad.mit.edu	37	12	112846235	112846235	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:112846235C>T	uc001ttu.2	-	2	455	c.226G>A	c.(226-228)GCT>ACT	p.A76T	RPL6_uc001ttv.2_Missense_Mutation_p.A76T|RPL6_uc009zwd.1_Missense_Mutation_p.A76T	NM_001024662	NP_001019833	Q02878	RL6_HUMAN	ribosomal protein L6	76					endocrine pancreas development|regulation of transcription, DNA-dependent|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	DNA binding|RNA binding|structural constituent of ribosome			large_intestine(1)	1																		---	---	---	---
OAS3	4940	broad.mit.edu	37	12	113386827	113386827	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:113386827C>T	uc001tug.2	+	6	1278	c.1191C>T	c.(1189-1191)ATC>ATT	p.I397I		NM_006187	NP_006178	Q9Y6K5	OAS3_HUMAN	2'-5'oligoadenylate synthetase 3	397	Linker.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			central_nervous_system(1)	1																		---	---	---	---
MED13L	23389	broad.mit.edu	37	12	116446528	116446528	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:116446528G>A	uc001tvw.2	-	10	1745	c.1690C>T	c.(1690-1692)CGA>TGA	p.R564*		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	564					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)														---	---	---	---
GCN1L1	10985	broad.mit.edu	37	12	120588944	120588944	+	Intron	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:120588944C>T	uc001txo.2	-							NM_006836	NP_006827			GCN1 general control of amino-acid synthesis						regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)																	---	---	---	---
GCN1L1	10985	broad.mit.edu	37	12	120593241	120593241	+	Intron	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:120593241G>A	uc001txo.2	-							NM_006836	NP_006827			GCN1 general control of amino-acid synthesis						regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)																	---	---	---	---
ANAPC5	51433	broad.mit.edu	37	12	121756174	121756174	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:121756174G>A	uc001uag.2	-	15	1921	c.1799C>T	c.(1798-1800)GCG>GTG	p.A600V	ANAPC5_uc010szu.1_Missense_Mutation_p.A266V|ANAPC5_uc001uae.2_Missense_Mutation_p.A164V|ANAPC5_uc010szv.1_Missense_Mutation_p.A202V|ANAPC5_uc001uaf.2_RNA|ANAPC5_uc001uah.2_Missense_Mutation_p.A488V|ANAPC5_uc001uai.1_Intron	NM_016237	NP_057321	Q9UJX4	APC5_HUMAN	anaphase-promoting complex subunit 5 isoform a	600	TPR 3.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G2/M transition of mitotic cell cycle|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding|ubiquitin-protein ligase activity			skin(3)|breast(2)|kidney(1)	6	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)																	---	---	---	---
ORAI1	84876	broad.mit.edu	37	12	122078974	122078974	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:122078974G>A	uc010szz.1	+	3	524	c.331G>A	c.(331-333)GCT>ACT	p.A111T		NM_032790	NP_116179	Q96D31	CRCM1_HUMAN	calcium release-activated calcium channel	111	Extracellular (Potential).				platelet activation|positive regulation of calcium ion transport	integral to plasma membrane	protein binding|store-operated calcium channel activity				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000415)|Epithelial(86;0.00148)														---	---	---	---
TMEM120B	144404	broad.mit.edu	37	12	122150877	122150877	+	Intron	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:122150877C>T	uc001ubc.3	+						TMEM120B_uc009zxh.2_Intron	NM_001080825	NP_001074294			transmembrane protein 120B							integral to membrane					0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;5.75e-05)|Epithelial(86;0.000128)|BRCA - Breast invasive adenocarcinoma(302;0.238)														---	---	---	---
ABCB9	23457	broad.mit.edu	37	12	123419951	123419951	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:123419951G>A	uc001udm.3	-	10	2081	c.1771C>T	c.(1771-1773)CTG>TTG	p.L591L	ABCB9_uc010tai.1_Silent_p.L198L|ABCB9_uc009zxr.2_Intron|ABCB9_uc001udo.3_Silent_p.L548L|ABCB9_uc010taj.1_Silent_p.L528L|ABCB9_uc001udp.2_Silent_p.L591L|ABCB9_uc001udq.2_Silent_p.L310L	NM_019625	NP_062571	Q9NP78	ABCB9_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	591	ABC transporter.				positive regulation of T cell mediated cytotoxicity|protein transport	lysosomal membrane|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.84e-05)|Epithelial(86;0.000152)|BRCA - Breast invasive adenocarcinoma(302;0.111)														---	---	---	---
DNAH10	196385	broad.mit.edu	37	12	124359903	124359903	+	Silent	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:124359903A>G	uc001uft.3	+	46	7735	c.7710A>G	c.(7708-7710)GCA>GCG	p.A2570A		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2570	AAA 3 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)														---	---	---	---
NCOR2	9612	broad.mit.edu	37	12	124915272	124915272	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:124915272C>T	uc010tba.1	-	9	1061	c.944G>A	c.(943-945)CGC>CAC	p.R315H	NCOR2_uc010tay.1_Missense_Mutation_p.R315H|NCOR2_uc010taz.1_Missense_Mutation_p.R315H|NCOR2_uc010tbb.1_Missense_Mutation_p.R315H|NCOR2_uc010tbc.1_Missense_Mutation_p.R315H|NCOR2_uc001ugj.1_Missense_Mutation_p.R315H|NCOR2_uc001ugk.1_Missense_Mutation_p.R315H	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	315					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)														---	---	---	---
ULK1	8408	broad.mit.edu	37	12	132394489	132394489	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:132394489C>T	uc001uje.2	+	10	1019	c.751C>T	c.(751-753)CTG>TTG	p.L251L		NM_003565	NP_003556	O75385	ULK1_HUMAN	Unc-51-like kinase 1	251	Protein kinase.				autophagy|protein localization|regulation of autophagy	autophagic vacuole|cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	ATP binding|protein complex binding|protein serine/threonine kinase activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.07e-08)|Epithelial(86;2.56e-07)|all cancers(50;3.01e-07)														---	---	---	---
GALNT9	50614	broad.mit.edu	37	12	132688118	132688118	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:132688118G>A	uc001ukc.3	-	7	1311	c.1195C>T	c.(1195-1197)CGC>TGC	p.R399C	GALNT9_uc009zyr.2_Missense_Mutation_p.R173C|GALNT9_uc001ukb.2_Missense_Mutation_p.R256C|GALNT9_uc001uka.2_Missense_Mutation_p.R33C	NM_001122636	NP_001116108	Q9HCQ5	GALT9_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	399	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.241)		OV - Ovarian serous cystadenocarcinoma(86;7.49e-08)|Epithelial(86;3.55e-07)|all cancers(50;2.09e-05)														---	---	---	---
POLE	5426	broad.mit.edu	37	12	133210876	133210876	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:133210876G>A	uc001uks.1	-	43	5944	c.5900C>T	c.(5899-5901)GCG>GTG	p.A1967V	POLE_uc001ukq.1_Missense_Mutation_p.A177V|POLE_uc001ukr.1_Missense_Mutation_p.A771V|POLE_uc010tbq.1_RNA	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	1967					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)									DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					---	---	---	---
ZMYM5	9205	broad.mit.edu	37	13	20398930	20398930	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:20398930C>T	uc010tcn.1	-	8	1962	c.1697G>A	c.(1696-1698)CGG>CAG	p.R566Q	ZMYM5_uc001umm.1_Missense_Mutation_p.R390Q	NM_001142684	NP_001136156	Q9UJ78	ZMYM5_HUMAN	zinc finger protein 237 isoform 3	566						nucleus	zinc ion binding				0		all_cancers(29;2.96e-22)|all_epithelial(30;3.76e-20)|all_lung(29;4.38e-20)|Lung NSC(5;5.8e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.61e-05)|Epithelial(112;4.89e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00171)|Lung(94;0.00942)|LUSC - Lung squamous cell carcinoma(192;0.0431)														---	---	---	---
ZMYM5	9205	broad.mit.edu	37	13	20411871	20411871	+	Silent	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:20411871G>T	uc010tcn.1	-	6	1228	c.963C>A	c.(961-963)CCC>CCA	p.P321P	ZMYM5_uc001umm.1_Silent_p.P145P|ZMYM5_uc001umn.2_Silent_p.P321P|ZMYM5_uc001umo.2_3'UTR	NM_001142684	NP_001136156	Q9UJ78	ZMYM5_HUMAN	zinc finger protein 237 isoform 3	321	MYM-type 2.					nucleus	zinc ion binding				0		all_cancers(29;2.96e-22)|all_epithelial(30;3.76e-20)|all_lung(29;4.38e-20)|Lung NSC(5;5.8e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.61e-05)|Epithelial(112;4.89e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00171)|Lung(94;0.00942)|LUSC - Lung squamous cell carcinoma(192;0.0431)														---	---	---	---
SACS	26278	broad.mit.edu	37	13	23910322	23910322	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:23910322A>G	uc001uon.2	-	10	8282	c.7693T>C	c.(7693-7695)TTT>CTT	p.F2565L	SACS_uc001uoo.2_Missense_Mutation_p.F2418L|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	2565					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)														---	---	---	---
SACS	26278	broad.mit.edu	37	13	23911920	23911920	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:23911920G>A	uc001uon.2	-	10	6684	c.6095C>T	c.(6094-6096)TCG>TTG	p.S2032L	SACS_uc001uoo.2_Missense_Mutation_p.S1885L|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	2032			Missing (in SACS).		cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)														---	---	---	---
SACS	26278	broad.mit.edu	37	13	23913665	23913665	+	Silent	SNP	T	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:23913665T>A	uc001uon.2	-	10	4939	c.4350A>T	c.(4348-4350)GGA>GGT	p.G1450G	SACS_uc001uoo.2_Silent_p.G1303G|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	1450					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)														---	---	---	---
SACS	26278	broad.mit.edu	37	13	23928948	23928948	+	Silent	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:23928948A>G	uc001uon.2	-	8	2392	c.1803T>C	c.(1801-1803)ATT>ATC	p.I601I	SACS_uc001uoo.2_Silent_p.I454I|SACS_uc001uop.1_Silent_p.I388I|SACS_uc001uoq.1_Silent_p.I454I	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	601					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)														---	---	---	---
SACS	26278	broad.mit.edu	37	13	23942624	23942624	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:23942624G>A	uc001uon.2	-	5	851	c.262C>T	c.(262-264)CGA>TGA	p.R88*	SACS_uc001uoo.2_5'UTR|SACS_uc001uoq.1_5'UTR	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	88					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)														---	---	---	---
MTMR6	9107	broad.mit.edu	37	13	25832819	25832819	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:25832819C>T	uc001uqf.3	-	7	1057	c.738G>A	c.(736-738)ATG>ATA	p.M246I	MTMR6_uc001uqe.1_Missense_Mutation_p.M246I	NM_004685	NP_004676	Q9Y217	MTMR6_HUMAN	myotubularin related protein 6	246	Myotubularin phosphatase.					cytoplasm|nuclear envelope	calcium-activated potassium channel activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			ovary(2)|skin(2)	4		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.00927)|Epithelial(112;0.0474)|OV - Ovarian serous cystadenocarcinoma(117;0.164)														---	---	---	---
PAN3	255967	broad.mit.edu	37	13	28834653	28834653	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:28834653G>A	uc001urz.2	+	7	888	c.880G>A	c.(880-882)GCA>ACA	p.A294T	PAN3_uc010tdo.1_Missense_Mutation_p.A440T|PAN3_uc001ury.2_Missense_Mutation_p.A128T|PAN3_uc001urx.2_Missense_Mutation_p.A240T	NM_175854	NP_787050	Q58A45	PAN3_HUMAN	PABP1-dependent poly A-specific ribonuclease	440	Interaction with polyadenylate-binding protein.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening	centrosome|cytosol	ATP binding|protein kinase activity			ovary(1)	1	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)	Colorectal(13;0.000334)	all cancers(112;0.0102)|Epithelial(112;0.0803)|GBM - Glioblastoma multiforme(144;0.121)|OV - Ovarian serous cystadenocarcinoma(117;0.13)|Lung(94;0.174)														---	---	---	---
DGKH	160851	broad.mit.edu	37	13	42772702	42772702	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:42772702G>A	uc001uyl.1	+	18	2277	c.2256G>A	c.(2254-2256)ACG>ACA	p.T752T	DGKH_uc010tfh.1_Silent_p.T752T|DGKH_uc001uym.1_Silent_p.T752T|DGKH_uc010tfi.1_Silent_p.T507T|DGKH_uc010tfj.1_Silent_p.T607T|DGKH_uc001uyn.1_RNA|DGKH_uc001uyo.1_Silent_p.T607T|DGKH_uc001uyp.2_RNA	NM_178009	NP_821077	Q86XP1	DGKH_HUMAN	diacylglycerol kinase, eta isoform 2	752					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation|protein oligomerization	endosome|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(2)	2		Lung NSC(96;1.02e-05)|Prostate(109;0.0168)|Lung SC(185;0.0262)|Breast(139;0.0709)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;5.88e-05)|GBM - Glioblastoma multiforme(144;0.000935)|BRCA - Breast invasive adenocarcinoma(63;0.109)														---	---	---	---
ENOX1	55068	broad.mit.edu	37	13	43900635	43900635	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:43900635C>T	uc001uza.3	-	10	1363	c.1063G>A	c.(1063-1065)GCT>ACT	p.A355T	ENOX1_uc001uzb.3_Missense_Mutation_p.A355T|ENOX1_uc001uzc.3_Missense_Mutation_p.A355T|ENOX1_uc001uyz.3_Intron|ENOX1_uc010tfm.1_Missense_Mutation_p.A168T	NM_001127615	NP_001121087	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	355					electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			pancreas(1)|skin(1)	2		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)														---	---	---	---
SLC25A30	253512	broad.mit.edu	37	13	45976499	45976499	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:45976499T>A	uc001vag.2	-	6	537	c.400A>T	c.(400-402)ATG>TTG	p.M134L	SLC25A30_uc010tfs.1_Missense_Mutation_p.M59L|SLC25A30_uc001vah.2_Missense_Mutation_p.M59L|SLC25A30_uc010tft.1_Missense_Mutation_p.M83L|SLC25A30_uc001vaf.2_5'UTR	NM_001010875	NP_001010875	Q5SVS4	KMCP1_HUMAN	solute carrier family 25, member 30	134	Solcar 2.				mitochondrial transport	integral to membrane|mitochondrial inner membrane	binding			breast(1)	1		Lung NSC(96;0.00227)|Prostate(109;0.00578)|Breast(56;0.0192)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.95e-05)														---	---	---	---
LCP1	3936	broad.mit.edu	37	13	46721114	46721114	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:46721114G>A	uc001vaz.3	-	10	1229	c.1103C>T	c.(1102-1104)GCC>GTC	p.A368V	LCP1_uc001vay.3_5'Flank|LCP1_uc001vba.3_Missense_Mutation_p.A368V	NM_002298	NP_002289	P13796	PLSL_HUMAN	L-plastin	368	CH 2.|Actin-binding 1.				regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding			lung(4)|ovary(3)	7		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)				T	BCL6	NHL 								---	---	---	---
C13orf18	80183	broad.mit.edu	37	13	46946248	46946248	+	Silent	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:46946248A>G	uc010acl.2	-	3	968	c.363T>C	c.(361-363)AGT>AGC	p.S121S	C13orf18_uc001vbf.3_Silent_p.S54S|C13orf18_uc001vbg.3_5'UTR|C13orf18_uc010tfz.1_Intron|C13orf18_uc010acm.2_5'UTR|C13orf18_uc010acn.2_Intron|C13orf18_uc001vbe.3_Silent_p.S121S|C13orf18_uc001vbh.3_Silent_p.S121S|C13orf18_uc001vbi.3_Intron|C13orf18_uc010aco.1_Silent_p.S121S|C13orf18_uc010tga.1_Silent_p.S54S	NM_025113	NP_079389	Q9H714	CM018_HUMAN	hypothetical protein LOC80183	121	Ser-rich.										0		Lung NSC(96;2.31e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;2.19e-05)														---	---	---	---
PHF11	51131	broad.mit.edu	37	13	50097359	50097359	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:50097359G>T	uc001vdb.2	+	7	956	c.619G>T	c.(619-621)GAG>TAG	p.E207*	PHF11_uc001vdc.2_Nonsense_Mutation_p.E168*|PHF11_uc001vdd.2_RNA	NM_001040443	NP_001035533	Q9UIL8	PHF11_HUMAN	PHD finger protein 11 isoform a	207					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding				0		Lung NSC(96;2.1e-05)|Breast(56;0.00017)|Prostate(109;0.00314)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.38e-09)														---	---	---	---
PCDH17	27253	broad.mit.edu	37	13	58207120	58207120	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:58207120C>T	uc001vhq.1	+	1	1332	c.440C>T	c.(439-441)CCG>CTG	p.P147L	PCDH17_uc010aec.1_Missense_Mutation_p.P147L	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	147	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)														---	---	---	---
DIAPH3	81624	broad.mit.edu	37	13	60485860	60485860	+	Intron	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:60485860G>A	uc001vht.2	-						DIAPH3_uc001vhu.2_Intron|DIAPH3_uc001vhv.2_Intron	NM_001042517	NP_001035982			diaphanous homolog 3 isoform a						actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)														---	---	---	---
LMO7	4008	broad.mit.edu	37	13	76427378	76427378	+	Silent	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:76427378C>A	uc001vjv.2	+	25	4576	c.3816C>A	c.(3814-3816)GCC>GCA	p.A1272A	LMO7_uc010thv.1_Silent_p.A1223A|LMO7_uc010thw.1_Silent_p.A1149A	NM_015842	NP_056667	Q8WWI1	LMO7_HUMAN	LIM domain only 7 isoform 2	1557						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)|prostate(1)|skin(1)	5		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)														---	---	---	---
MYCBP2	23077	broad.mit.edu	37	13	77632491	77632491	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:77632491G>A	uc001vkf.2	-	79	13168	c.13077C>T	c.(13075-13077)TGC>TGT	p.C4359C	MYCBP2_uc010aev.2_Silent_p.C3763C|MYCBP2_uc001vke.2_Silent_p.C976C	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	4359					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)														---	---	---	---
SLITRK1	114798	broad.mit.edu	37	13	84453682	84453682	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:84453682G>A	uc001vlk.2	-	1	2847	c.1961C>T	c.(1960-1962)GCC>GTC	p.A654V		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	654	Cytoplasmic (Potential).					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)														---	---	---	---
SLITRK1	114798	broad.mit.edu	37	13	84454544	84454544	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:84454544A>C	uc001vlk.2	-	1	1985	c.1099T>G	c.(1099-1101)TTG>GTG	p.L367V		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	367	Extracellular (Potential).|LRRNT 2.					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)														---	---	---	---
SLITRK1	114798	broad.mit.edu	37	13	84455457	84455457	+	Silent	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:84455457A>G	uc001vlk.2	-	1	1072	c.186T>C	c.(184-186)CAT>CAC	p.H62H		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	62	LRR 1.|Extracellular (Potential).					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)														---	---	---	---
DCT	1638	broad.mit.edu	37	13	95131277	95131277	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:95131277C>T	uc001vlv.3	-	1	660	c.233G>A	c.(232-234)CGA>CAA	p.R78Q	DCT_uc010afh.2_Missense_Mutation_p.R78Q	NM_001922	NP_001913	P40126	TYRP2_HUMAN	dopachrome tautomerase isoform 1	78	Lumenal, melanosome (Potential).				epidermis development|melanin biosynthetic process from tyrosine	cytosol|integral to membrane|melanosome membrane|microsome	copper ion binding|dopachrome isomerase activity|oxidoreductase activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;3.71e-42)|all_epithelial(2;3.76e-31)|all_lung(2;5.16e-14)|Lung NSC(4;1.33e-13)|Breast(118;0.0013)|Hepatocellular(115;0.00886)|Renal(2;0.00988)		COAD - Colon adenocarcinoma(199;7.07e-05)|GBM - Glioblastoma multiforme(99;0.000472)														---	---	---	---
ABCC4	10257	broad.mit.edu	37	13	95686970	95686970	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:95686970T>A	uc001vmd.3	-	30	3878	c.3759A>T	c.(3757-3759)AAA>AAT	p.K1253N	ABCC4_uc010afj.2_Missense_Mutation_p.K44N|ABCC4_uc010afk.2_Missense_Mutation_p.K1206N	NM_005845	NP_005836	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C, member 4	1253	ABC transporter 2.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			central_nervous_system(3)|skin(1)	4	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)													---	---	---	---
UBAC2	337867	broad.mit.edu	37	13	99992580	99992580	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:99992580G>A	uc001voa.3	+	7	1052	c.568G>A	c.(568-570)GGT>AGT	p.G190S	UBAC2_uc010tiu.1_Missense_Mutation_p.G212S|UBAC2_uc001vob.3_Missense_Mutation_p.G163S|UBAC2_uc010tiv.1_Intron|UBAC2_uc001vod.2_Missense_Mutation_p.G77S|UBAC2_uc001voc.2_Missense_Mutation_p.G155S|UBAC2_uc010tiw.1_RNA|UBAC2_uc001voh.2_5'UTR	NM_001144072	NP_001137544	Q8NBM4	UBAC2_HUMAN	UBA domain containing 2 isoform 1	190	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)																	---	---	---	---
PCCA	5095	broad.mit.edu	37	13	100909900	100909900	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:100909900G>A	uc001voo.2	+	9	727	c.689G>A	c.(688-690)CGC>CAC	p.R230H	PCCA_uc010aga.2_Missense_Mutation_p.R204H|PCCA_uc010tiz.1_Missense_Mutation_p.R230H	NM_000282	NP_000273	P05165	PCCA_HUMAN	propionyl-Coenzyme A carboxylase, alpha	230	ATP-grasp.|Biotin carboxylation.				fatty acid beta-oxidation	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|enzyme binding|metal ion binding|propionyl-CoA carboxylase activity			skin(2)	2	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Biotin(DB00121)													---	---	---	---
COL4A2	1284	broad.mit.edu	37	13	111156281	111156281	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:111156281G>T	uc001vqx.2	+	44	4515	c.4226G>T	c.(4225-4227)AGG>ATG	p.R1409M		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein	1409	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)															---	---	---	---
C13orf28	122258	broad.mit.edu	37	13	113030776	113030776	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:113030776C>T	uc001vsd.1	+	1	108	c.77C>T	c.(76-78)CCG>CTG	p.P26L		NM_145248	NP_660291	Q96KW9	SPAC7_HUMAN	hypothetical protein LOC122258 precursor	26						extracellular region					0	all_lung(23;0.000633)|Lung NSC(43;0.0161)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0997)|Medulloblastoma(90;0.163)																	---	---	---	---
LAMP1	3916	broad.mit.edu	37	13	113975961	113975961	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:113975961C>T	uc001vtm.1	+	8	1314	c.1033C>T	c.(1033-1035)CGT>TGT	p.R345C	LAMP1_uc010tka.1_Missense_Mutation_p.R292C	NM_005561	NP_005552	P11279	LAMP1_HUMAN	lysosomal-associated membrane protein 1	345	Lumenal (Potential).|Second lumenal domain.					endosome membrane|integral to plasma membrane|lysosomal membrane|membrane fraction				central_nervous_system(2)	2	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)															---	---	---	---
GRTP1	79774	broad.mit.edu	37	13	114005253	114005253	+	Missense_Mutation	SNP	G	A	A	rs146277531	byFrequency	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:114005253G>A	uc001vtn.2	-	4	473	c.376C>T	c.(376-378)CGG>TGG	p.R126W	GRTP1_uc010tkb.1_Missense_Mutation_p.R48W|GRTP1_uc010tkc.1_Missense_Mutation_p.R126W|GRTP1_uc010agv.1_RNA	NM_024719	NP_078995	Q5TC63	GRTP1_HUMAN	growth hormone regulated TBC protein 1	126	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0314)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0978)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)															---	---	---	---
FAM70B	348013	broad.mit.edu	37	13	114469190	114469190	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:114469190C>T	uc001vuh.2	+	2	176	c.149C>T	c.(148-150)ACG>ATG	p.T50M	FAM70B_uc010tkh.1_Missense_Mutation_p.T50M	NM_182614	NP_872420	Q8WV15	FA70B_HUMAN	family with sequence similarity 70, member B	50						integral to membrane					0	Lung NSC(43;0.00976)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_lung(25;0.123)|all_epithelial(44;0.133)	all cancers(43;0.181)															---	---	---	---
RNASE7	84659	broad.mit.edu	37	14	21511371	21511371	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:21511371G>A	uc001vzk.3	+	2	477	c.220G>A	c.(220-222)GAG>AAG	p.E74K	NDRG2_uc010tll.1_Intron|RNASE7_uc001vzl.2_RNA	NM_032572	NP_115961	Q9H1E1	RNAS7_HUMAN	ribonuclease, RNase A family, 7 precursor	74					defense response to bacterium|innate immune response	extracellular region	nucleic acid binding|pancreatic ribonuclease activity			ovary(1)	1	all_cancers(95;0.000759)		OV - Ovarian serous cystadenocarcinoma(11;3.42e-11)|Epithelial(56;5.57e-09)|all cancers(55;2.36e-08)	GBM - Glioblastoma multiforme(265;0.0191)														---	---	---	---
FLJ10357	55701	broad.mit.edu	37	14	21542132	21542132	+	Silent	SNP	G	A	A	rs114625560	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:21542132G>A	uc001vzp.2	+	3	272	c.243G>A	c.(241-243)CCG>CCA	p.P81P	FLJ10357_uc001vzn.1_Silent_p.P81P|FLJ10357_uc001vzo.1_Intron|FLJ10357_uc010aij.2_RNA|FLJ10357_uc010tln.1_5'UTR	NM_018071	NP_060541	Q8TER5	ARH40_HUMAN	hypothetical protein LOC55701	81					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity				0	all_cancers(95;0.00185)		OV - Ovarian serous cystadenocarcinoma(11;5.79e-11)|Epithelial(56;8.35e-09)|all cancers(55;4.23e-08)	GBM - Glioblastoma multiforme(265;0.0197)														---	---	---	---
Unknown	0	broad.mit.edu	37	14	22315374	22315374	+	Intron	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:22315374C>T	uc010tmf.1	+						uc001wbw.2_Intron|uc010tmg.1_Intron|uc001wby.2_Intron|uc010ait.1_Silent_p.D85D|uc001wbz.1_Silent_p.D104D					SubName: Full=Putative uncharacterized protein ENSP00000374943;																														---	---	---	---
PRMT5	10419	broad.mit.edu	37	14	23397733	23397733	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:23397733G>A	uc001whm.1	-	2	293	c.202C>T	c.(202-204)CGA>TGA	p.R68*	PRMT5_uc001whl.1_Nonsense_Mutation_p.R51*|PRMT5_uc010akd.1_RNA|PRMT5_uc010tnf.1_Intron|PRMT5_uc010tng.1_Nonsense_Mutation_p.R51*|PRMT5_uc010tnh.1_Nonsense_Mutation_p.R68*|PRMT5_uc001whn.1_Nonsense_Mutation_p.R51*	NM_006109	NP_006100	O14744	ANM5_HUMAN	protein arginine methyltransferase 5 isoform a	68					cell proliferation|histone H4-R3 methylation|ncRNA metabolic process|regulation of mitosis|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	histone-arginine N-methyltransferase activity|protein binding|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding			ovary(1)	1	all_cancers(95;2.76e-05)			GBM - Glioblastoma multiforme(265;0.0126)														---	---	---	---
MYH7	4625	broad.mit.edu	37	14	23898199	23898199	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:23898199C>T	uc001wjx.2	-	14	1478	c.1372G>A	c.(1372-1374)GGA>AGA	p.G458R		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	458	Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)														---	---	---	---
PCK2	5106	broad.mit.edu	37	14	24569425	24569425	+	Intron	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:24569425A>G	uc001wlt.2	+						NRL_uc001wlq.2_Intron|PCK2_uc001wlr.1_Intron|PCK2_uc001wls.2_Missense_Mutation_p.M413V|PCK2_uc010tnw.1_Intron|PCK2_uc010ald.2_3'UTR|PCK2_uc010ale.2_3'UTR|PCK2_uc010tnx.1_Intron|PCK2_uc001wlu.3_Intron	NM_004563	NP_004554			mitochondrial phosphoenolpyruvate carboxykinase						gluconeogenesis	mitochondrial matrix	GTP binding|metal ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			ovary(1)	1				GBM - Glioblastoma multiforme(265;0.0184)														---	---	---	---
RNF31	55072	broad.mit.edu	37	14	24620520	24620520	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:24620520G>T	uc001wmn.1	+	9	1918	c.1669G>T	c.(1669-1671)GCC>TCC	p.A557S	RNF31_uc001wml.1_Missense_Mutation_p.A406S|RNF31_uc001wmm.1_Intron|RNF31_uc010alg.1_Missense_Mutation_p.A316S|RNF31_uc001wmo.1_Missense_Mutation_p.A24S|RNF31_uc001wmp.2_RNA	NM_017999	NP_060469	Q96EP0	RNF31_HUMAN	ring finger protein 31	557					CD40 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein linear polyubiquitination|T cell receptor signaling pathway	CD40 receptor complex|internal side of plasma membrane|LUBAC complex	ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00861)														---	---	---	---
REC8	9985	broad.mit.edu	37	14	24641958	24641958	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:24641958C>T	uc001wmr.2	+	3	520	c.93C>T	c.(91-93)CGC>CGT	p.R31R	REC8_uc001wms.2_Silent_p.R31R	NM_005132	NP_005123	O95072	REC8_HUMAN	REC8 homolog	31					mitotic metaphase/anaphase transition|mitotic prometaphase|reciprocal meiotic recombination|sister chromatid cohesion	nucleoplasm					0				GBM - Glioblastoma multiforme(265;0.00839)														---	---	---	---
NYNRIN	57523	broad.mit.edu	37	14	24884675	24884675	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:24884675G>A	uc001wpf.3	+	9	4038	c.3720G>A	c.(3718-3720)GCG>GCA	p.A1240A		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	1240					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
PRKD1	5587	broad.mit.edu	37	14	30102157	30102157	+	Intron	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:30102157A>G	uc001wqh.2	-							NM_002742	NP_002733			protein kinase D1						cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)														---	---	---	---
NPAS3	64067	broad.mit.edu	37	14	34269448	34269448	+	Silent	SNP	G	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:34269448G>C	uc001wru.2	+	12	1999	c.1935G>C	c.(1933-1935)GTG>GTC	p.V645V	NPAS3_uc001wrs.2_Silent_p.V632V|NPAS3_uc001wrt.2_Silent_p.V613V|NPAS3_uc001wrv.2_Silent_p.V615V	NM_173159	NP_071406	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3 isoform 3	645					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)|skin(1)	2	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)														---	---	---	---
PAX9	5083	broad.mit.edu	37	14	37132207	37132207	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:37132207T>C	uc001wty.3	+	3	827	c.110T>C	c.(109-111)ATC>ACC	p.I37T	PAX9_uc010amq.2_5'Flank	NM_006194	NP_006185	P55771	PAX9_HUMAN	paired box 9	37	Paired.				multicellular organismal development|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)|Breast(36;0.218)		Lung(8;1.12e-09)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.00357)|all cancers(34;0.00998)|LUSC - Lung squamous cell carcinoma(13;0.0189)	GBM - Glioblastoma multiforme(112;0.0181)														---	---	---	---
NIN	51199	broad.mit.edu	37	14	51224918	51224918	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:51224918G>A	uc001wym.2	-	18	3021	c.2830C>T	c.(2830-2832)CAC>TAC	p.H944Y	NIN_uc001wyi.2_Missense_Mutation_p.H944Y|NIN_uc001wyj.2_Intron|NIN_uc001wyk.2_Intron|NIN_uc010tqp.1_Missense_Mutation_p.H950Y|NIN_uc001wyo.2_Missense_Mutation_p.H944Y	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	944	Potential.				centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)							T	PDGFRB	MPD								---	---	---	---
PELI2	57161	broad.mit.edu	37	14	56755227	56755227	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:56755227G>A	uc001xch.2	+	4	668	c.382G>A	c.(382-384)GAA>AAA	p.E128K		NM_021255	NP_067078	Q9HAT8	PELI2_HUMAN	pellino 2	128					innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of protein phosphorylation|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	protein binding			ovary(1)	1																		---	---	---	---
MUDENG	55745	broad.mit.edu	37	14	57741440	57741440	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:57741440A>G	uc001xcv.2	+	2	980	c.553A>G	c.(553-555)AAT>GAT	p.N185D	MUDENG_uc001xcu.3_Missense_Mutation_p.N185D|MUDENG_uc010tri.1_Intron|MUDENG_uc010trj.1_Missense_Mutation_p.N82D	NM_018229	NP_060699	Q9H0R1	MUDEN_HUMAN	Mu-2 related death-inducing protein	185					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex				ovary(1)	1																		---	---	---	---
ACTR10	55860	broad.mit.edu	37	14	58678087	58678087	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:58678087T>A	uc001xdf.2	+	5	523	c.420T>A	c.(418-420)GAT>GAA	p.D140E	C14orf37_uc010tro.1_Intron|ACTR10_uc001xdg.2_Translation_Start_Site|ACTR10_uc001xdh.2_Translation_Start_Site|ACTR10_uc010trp.1_5'Flank|ACTR10_uc010apc.2_5'Flank	NM_018477	NP_060947	Q9NZ32	ARP10_HUMAN	uncharacterized hypothalamus protein HARP11	140						cytoplasm				central_nervous_system(1)	1																		---	---	---	---
SNAPC1	6617	broad.mit.edu	37	14	62248987	62248987	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:62248987G>A	uc001xft.2	+	8	952	c.848G>A	c.(847-849)CGT>CAT	p.R283H		NM_003082	NP_003073	Q16533	SNPC1_HUMAN	small nuclear RNA activating complex,	283					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding				0				OV - Ovarian serous cystadenocarcinoma(108;0.0639)|BRCA - Breast invasive adenocarcinoma(234;0.186)														---	---	---	---
SYNE2	23224	broad.mit.edu	37	14	64522715	64522715	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:64522715C>T	uc001xgm.2	+	49	10028	c.9798C>T	c.(9796-9798)ACC>ACT	p.T3266T	SYNE2_uc001xgl.2_Silent_p.T3266T|SYNE2_uc010apw.1_5'UTR	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	3266	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)														---	---	---	---
TMEM229B	161145	broad.mit.edu	37	14	67940344	67940344	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:67940344G>A	uc001xjk.2	-	3	707	c.297C>T	c.(295-297)AAC>AAT	p.N99N	TMEM229B_uc001xjj.1_RNA	NM_182526	NP_872332	Q8NBD8	T229B_HUMAN	transmembrane protein 229B	99	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1																		---	---	---	---
DCAF5	8816	broad.mit.edu	37	14	69521972	69521972	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:69521972G>A	uc001xkp.2	-	9	1650	c.1431C>T	c.(1429-1431)GCC>GCT	p.A477A	DCAF5_uc001xkq.2_Silent_p.A476A	NM_003861	NP_003852	Q96JK2	DCAF5_HUMAN	WD repeat domain 22	477						CUL4 RING ubiquitin ligase complex				ovary(1)|central_nervous_system(1)	2																		---	---	---	---
SIPA1L1	26037	broad.mit.edu	37	14	72190527	72190527	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:72190527G>A	uc001xms.2	+	16	4783	c.4435G>A	c.(4435-4437)GCT>ACT	p.A1479T	SIPA1L1_uc001xmt.2_Missense_Mutation_p.A1458T|SIPA1L1_uc001xmu.2_Missense_Mutation_p.A1458T|SIPA1L1_uc001xmv.2_Missense_Mutation_p.A1479T|SIPA1L1_uc010ttm.1_Missense_Mutation_p.A933T|SIPA1L1_uc001xmw.2_Missense_Mutation_p.A244T	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	1479	Ser-rich.				actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)														---	---	---	---
DPF3	8110	broad.mit.edu	37	14	73137952	73137952	+	Intron	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:73137952C>T	uc001xnc.2	-						DPF3_uc001xnd.1_RNA|DPF3_uc001xnf.2_RNA|DPF3_uc010ari.1_Silent_p.T322T|DPF3_uc010ttq.1_Silent_p.T332T	NM_012074	NP_036206			D4, zinc and double PHD fingers, family 3						chromatin modification|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nBAF complex	nucleic acid binding|zinc ion binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00649)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)														---	---	---	---
DCAF4	26094	broad.mit.edu	37	14	73425339	73425339	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:73425339G>A	uc001xng.2	+	14	1534	c.1314G>A	c.(1312-1314)ACG>ACA	p.T438T	DCAF4_uc001xnj.2_Silent_p.T432T|DCAF4_uc010ttr.1_Silent_p.T417T|DCAF4_uc001xnh.2_Silent_p.T338T|DCAF4_uc010tts.1_Silent_p.T378T|DCAF4_uc010ttt.1_Silent_p.T224T|DCAF4_uc001xni.2_Silent_p.T268T	NM_015604	NP_056419	Q8WV16	DCAF4_HUMAN	DDB1 and CUL4 associated factor 4 isoform 1	438	WD 2.					CUL4 RING ubiquitin ligase complex				ovary(1)|central_nervous_system(1)|skin(1)	3																		---	---	---	---
PAPLN	89932	broad.mit.edu	37	14	73718367	73718367	+	Intron	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:73718367C>T	uc010ttx.1	+						PAPLN_uc001xnw.3_Intron|PAPLN_uc010arl.2_Intron|PAPLN_uc010ttw.1_Intron|PAPLN_uc010tty.1_Intron	NM_173462	NP_775733			papilin							proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)														---	---	---	---
PAPLN	89932	broad.mit.edu	37	14	73727431	73727431	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:73727431C>A	uc010ttx.1	+	16	2163	c.2000C>A	c.(1999-2001)CCT>CAT	p.P667H	PAPLN_uc001xnw.3_Missense_Mutation_p.P640H|PAPLN_uc010arl.2_RNA|PAPLN_uc010ttw.1_RNA|PAPLN_uc010tty.1_Missense_Mutation_p.P667H|PAPLN_uc010arm.2_Translation_Start_Site|PAPLN_uc010arn.2_5'Flank	NM_173462	NP_775733	O95428	PPN_HUMAN	papilin	667						proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)														---	---	---	---
ZNF410	57862	broad.mit.edu	37	14	74371775	74371775	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:74371775G>A	uc001xoz.1	+	7	1084	c.902G>A	c.(901-903)CGC>CAC	p.R301H	ZNF410_uc001xoy.1_RNA|ZNF410_uc010ary.1_RNA|ZNF410_uc010tuf.1_RNA|ZNF410_uc010tug.1_Missense_Mutation_p.R32H|ZNF410_uc010tuh.1_Missense_Mutation_p.R228H|ZNF410_uc010tui.1_RNA|ZNF410_uc010arz.1_Missense_Mutation_p.R318H|ZNF410_uc001xpa.1_Missense_Mutation_p.R105H|ZNF410_uc001xpb.1_Missense_Mutation_p.R301H|ZNF410_uc001xpc.1_Missense_Mutation_p.R248H|ZNF410_uc010tuj.1_Missense_Mutation_p.R105H	NM_021188	NP_067011	Q86VK4	ZN410_HUMAN	zinc finger protein 410	301	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00369)														---	---	---	---
RPS6KL1	83694	broad.mit.edu	37	14	75373815	75373815	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:75373815C>T	uc010tux.1	-	11	2080	c.1552G>A	c.(1552-1554)GAG>AAG	p.E518K	RPS6KL1_uc001xqx.1_3'UTR|RPS6KL1_uc001xqw.2_Missense_Mutation_p.E487K|RPS6KL1_uc010asd.1_RNA	NM_031464	NP_113652	Q9Y6S9	RPKL1_HUMAN	ribosomal protein S6 kinase-like 1	518	Protein kinase.					ribosome	ATP binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.00658)														---	---	---	---
MLH3	27030	broad.mit.edu	37	14	75509174	75509174	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:75509174T>G	uc001xrd.1	-	3	3503	c.3287A>C	c.(3286-3288)CAG>CCG	p.Q1096P	MLH3_uc001xre.1_Missense_Mutation_p.Q1096P|MLH3_uc010tuy.1_RNA	NM_001040108	NP_001035197	Q9UHC1	MLH3_HUMAN	mutL homolog 3 isoform 1	1096					mismatch repair|reciprocal meiotic recombination	chiasma|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|mismatched DNA binding|protein binding|satellite DNA binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00688)									MMR					---	---	---	---
TTLL5	23093	broad.mit.edu	37	14	76249812	76249812	+	Silent	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:76249812C>A	uc001xrx.2	+	26	3130	c.2925C>A	c.(2923-2925)TCC>TCA	p.S975S	TTLL5_uc010ask.1_Silent_p.S989S|TTLL5_uc001xrz.2_Silent_p.S550S|TTLL5_uc001xsa.2_Silent_p.S48S|TTLL5_uc001xry.1_RNA	NM_015072	NP_055887	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	975					protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.029)														---	---	---	---
SPTLC2	9517	broad.mit.edu	37	14	78063576	78063576	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:78063576A>G	uc001xub.2	-	2	468	c.280T>C	c.(280-282)TGG>CGG	p.W94R		NM_004863	NP_004854	O15270	SPTC2_HUMAN	serine palmitoyltransferase, long chain base	94						integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			upper_aerodigestive_tract(1)|ovary(1)	2			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0346)	L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)													---	---	---	---
C14orf156	81892	broad.mit.edu	37	14	78174534	78174534	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:78174534C>T	uc001xue.3	+	1	110	c.80C>T	c.(79-81)CCT>CTT	p.P27L	ALKBH1_uc001xuc.1_5'Flank|ALKBH1_uc001xud.1_5'Flank	NM_031210	NP_112487	Q9GZT3	SLIRP_HUMAN	SRA stem-loop-interacting RNA-binding protein	27	RRM.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	nucleotide binding|RNA binding				0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0276)														---	---	---	---
NRXN3	9369	broad.mit.edu	37	14	79181439	79181439	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:79181439C>T	uc001xun.2	+	5	1373	c.882C>T	c.(880-882)TGC>TGT	p.C294C	NRXN3_uc001xum.1_RNA|NRXN3_uc010asv.1_Silent_p.C428C	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	667	EGF-like 2.|Extracellular (Potential).				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)														---	---	---	---
STON2	85439	broad.mit.edu	37	14	81744393	81744393	+	Missense_Mutation	SNP	C	T	T	rs150621878		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:81744393C>T	uc010tvu.1	-	4	1463	c.1262G>A	c.(1261-1263)CGG>CAG	p.R421Q	STON2_uc001xvk.1_Missense_Mutation_p.R421Q|STON2_uc010tvt.1_Missense_Mutation_p.R218Q	NM_033104	NP_149095	Q8WXE9	STON2_HUMAN	stonin 2	421					endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			skin(3)|pancreas(2)	5				BRCA - Breast invasive adenocarcinoma(234;0.0348)														---	---	---	---
STON2	85439	broad.mit.edu	37	14	81744680	81744680	+	Silent	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:81744680G>T	uc010tvu.1	-	4	1176	c.975C>A	c.(973-975)CCC>CCA	p.P325P	STON2_uc001xvk.1_Silent_p.P325P|STON2_uc010tvt.1_Silent_p.P122P	NM_033104	NP_149095	Q8WXE9	STON2_HUMAN	stonin 2	325					endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			skin(3)|pancreas(2)	5				BRCA - Breast invasive adenocarcinoma(234;0.0348)														---	---	---	---
RIN3	79890	broad.mit.edu	37	14	93142923	93142923	+	Silent	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:93142923C>A	uc001yap.2	+	8	2591	c.2439C>A	c.(2437-2439)CTC>CTA	p.L813L	RIN3_uc010auk.2_Silent_p.L475L|RIN3_uc001yaq.2_Silent_p.L738L|RIN3_uc001yas.1_Silent_p.L475L	NM_024832	NP_079108	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	813	VPS9.				endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			lung(2)|ovary(1)	3		all_cancers(154;0.0701)																---	---	---	---
EML1	2009	broad.mit.edu	37	14	100380563	100380563	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:100380563C>T	uc001ygs.2	+	14	1611	c.1542C>T	c.(1540-1542)GGC>GGT	p.G514G	EML1_uc010tww.1_Silent_p.G502G|EML1_uc001ygr.2_Silent_p.G533G	NM_004434	NP_004425	O00423	EMAL1_HUMAN	echinoderm microtubule associated protein like 1	514						cytoplasm|microtubule|microtubule associated complex	calcium ion binding|protein binding			large_intestine(2)|pancreas(1)|ovary(1)|skin(1)	5		Melanoma(154;0.0879)|all_epithelial(191;0.216)																---	---	---	---
TECPR2	9895	broad.mit.edu	37	14	102916927	102916927	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:102916927G>T	uc001ylw.1	+	15	3495	c.3347G>T	c.(3346-3348)GGG>GTG	p.G1116V	TECPR2_uc010awl.2_Missense_Mutation_p.G1116V|TECPR2_uc010txx.1_Missense_Mutation_p.G279V	NM_014844	NP_055659	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	1116							protein binding			lung(1)|central_nervous_system(1)|skin(1)	3																		---	---	---	---
PPP1R13B	23368	broad.mit.edu	37	14	104204115	104204115	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:104204115A>C	uc001yof.1	-	15	3230	c.2947T>G	c.(2947-2949)TCA>GCA	p.S983A	PPP1R13B_uc010awv.1_Intron	NM_015316	NP_056131	Q96KQ4	ASPP1_HUMAN	apoptosis-stimulating protein of p53, 1	983	ANK 2.				apoptosis|induction of apoptosis|negative regulation of cell cycle	cytoplasm|nucleus|plasma membrane	protein binding			ovary(1)	1		all_cancers(154;0.173)|all_epithelial(191;0.131)|Melanoma(154;0.155)																---	---	---	---
INF2	64423	broad.mit.edu	37	14	105178032	105178032	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:105178032G>A	uc001ypb.2	+	16	2628	c.2485G>A	c.(2485-2487)GCA>ACA	p.A829T	INF2_uc010tyi.1_Missense_Mutation_p.A829T|INF2_uc001ypc.2_Missense_Mutation_p.A829T|INF2_uc010awz.1_RNA	NM_022489	NP_071934	Q27J81	INF2_HUMAN	inverted formin 2 isoform 1	829	FH2.				actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding				0		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)														---	---	---	---
AHNAK2	113146	broad.mit.edu	37	14	105418613	105418613	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:105418613C>T	uc010axc.1	-	7	3295	c.3175G>A	c.(3175-3177)GCT>ACT	p.A1059T	AHNAK2_uc001ypx.2_Missense_Mutation_p.A959T	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1059						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)															---	---	---	---
PACS2	23241	broad.mit.edu	37	14	105849842	105849842	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:105849842T>A	uc001yqt.2	+	16	1935	c.1760T>A	c.(1759-1761)ATC>AAC	p.I587N	PACS2_uc001yqs.2_Missense_Mutation_p.I512N|PACS2_uc001yqv.2_Missense_Mutation_p.I591N|PACS2_uc001yqu.2_Missense_Mutation_p.I591N	NM_015197	NP_056012	Q86VP3	PACS2_HUMAN	phosphofurin acidic cluster sorting protein 2	587					apoptosis|interspecies interaction between organisms	endoplasmic reticulum lumen|mitochondrion				pancreas(1)	1		all_cancers(154;0.0351)|all_epithelial(191;0.153)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)|Epithelial(46;0.036)	Epithelial(152;0.138)														---	---	---	---
ADAM6	8755	broad.mit.edu	37	14	106321322	106321322	+	RNA	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:106321322G>A	uc010tyt.1	-	3600		c.55829C>T			uc001yrs.2_Intron|uc001yrt.2_Intron|uc001yrw.1_Intron|uc001yrx.1_Intron|uc001yrz.1_Intron|uc001yse.2_Intron|uc001ysf.2_Intron|uc001ysj.2_Intron|uc001ysk.1_Intron|uc001ysl.1_Intron|uc001ysm.1_Intron|uc001ysn.1_Intron|uc001yso.1_Intron					Parts of antibodies, mostly variable regions.												0																		---	---	---	---
SNORD116-4	100033416	broad.mit.edu	37	15	25344728	25344728	+	Intron	SNP	G	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:25344728G>C	uc001yxh.1	+						SNORD116-4_uc001yxm.1_Intron|IPW_uc001yxn.3_Intron|SNORD116-28_uc001yxy.2_Intron|IPW_uc001yyb.3_Intron|uc001yyd.2_Intron|SNORD116-26_uc001yyl.2_RNA|SNORD116-27_uc001yym.2_5'Flank					Homo sapiens clone kid4 SNURF-SNRPN mRNA, downstream untranslated exons, alternatively spliced.												0																		---	---	---	---
HERC2	8924	broad.mit.edu	37	15	28443768	28443768	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:28443768A>T	uc001zbj.2	-	49	7970	c.7864T>A	c.(7864-7866)TAC>AAC	p.Y2622N	HERC2_uc001zbk.1_Missense_Mutation_p.Y157N	NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	2622					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)														---	---	---	---
HERC2	8924	broad.mit.edu	37	15	28446681	28446681	+	Missense_Mutation	SNP	G	A	A	rs138887223		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:28446681G>A	uc001zbj.2	-	48	7743	c.7637C>T	c.(7636-7638)ACG>ATG	p.T2546M	HERC2_uc001zbk.1_Missense_Mutation_p.T81M	NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	2546					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)														---	---	---	---
APBA2	321	broad.mit.edu	37	15	29406137	29406137	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:29406137G>A	uc001zck.2	+	13	2303	c.2096G>A	c.(2095-2097)CGC>CAC	p.R699H	APBA2_uc010uat.1_Missense_Mutation_p.R687H|APBA2_uc001zcl.2_Missense_Mutation_p.R687H	NM_005503	NP_005494	Q99767	APBA2_HUMAN	amyloid beta A4 precursor protein-binding,	699	PDZ 2.				nervous system development|protein transport		protein binding				0		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)														---	---	---	---
FMN1	342184	broad.mit.edu	37	15	33359153	33359153	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:33359153C>T	uc001zhf.3	-	1	933	c.933G>A	c.(931-933)ACG>ACA	p.T311T	FMN1_uc001zhg.2_Silent_p.T311T	NM_001103184	NP_001096654	Q68DA7	FMN1_HUMAN	formin 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			ovary(1)	1		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)														---	---	---	---
RYR3	6263	broad.mit.edu	37	15	34049794	34049794	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:34049794C>T	uc001zhi.2	+	60	8772	c.8702C>T	c.(8701-8703)GCC>GTC	p.A2901V	RYR3_uc010bar.2_Missense_Mutation_p.A2901V	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	2901	Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)														---	---	---	---
AQR	9716	broad.mit.edu	37	15	35182476	35182476	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:35182476C>T	uc001ziv.2	-	24	2802	c.2621G>A	c.(2620-2622)CGC>CAC	p.R874H		NM_014691	NP_055506	O60306	AQR_HUMAN	aquarius	874						catalytic step 2 spliceosome	RNA binding			large_intestine(1)	1		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)														---	---	---	---
RASGRP1	10125	broad.mit.edu	37	15	38786607	38786607	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:38786607C>T	uc001zke.3	-	16	2413	c.2235G>A	c.(2233-2235)CTG>CTA	p.L745L	RASGRP1_uc010bbe.2_RNA|RASGRP1_uc010bbf.2_Intron|RASGRP1_uc010bbg.2_Intron|RASGRP1_uc001zkd.3_Silent_p.L710L	NM_005739	NP_005730	O95267	GRP1_HUMAN	RAS guanyl releasing protein 1 isoform a	745	PT region; mediates the BCR-dependent translocation to plasma membrane (By similarity).				cell differentiation|platelet activation|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol|endoplasmic reticulum membrane|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|lipid binding|protein binding			large_intestine(1)|ovary(1)	2		all_cancers(109;6.38e-17)|all_epithelial(112;5.51e-15)|Lung NSC(122;2.12e-11)|all_lung(180;5.63e-10)|Melanoma(134;0.0574)		GBM - Glioblastoma multiforme(113;1.97e-07)|BRCA - Breast invasive adenocarcinoma(123;0.00248)														---	---	---	---
BMF	90427	broad.mit.edu	37	15	40396430	40396430	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:40396430C>T	uc001zkv.2	-	3	490	c.404G>A	c.(403-405)CGA>CAA	p.R135Q	BMF_uc001zkt.2_Intron|BMF_uc001zku.2_Intron|BMF_uc001zkw.2_Missense_Mutation_p.R135Q	NM_033503	NP_277038	Q96LC9	BMF_HUMAN	Bcl2 modifying factor isoform bmf-1	135	BH3.				activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria	cytosol|mitochondrial outer membrane|myosin complex|plasma membrane	protein binding			ovary(1)	1		all_cancers(109;4.18e-18)|all_epithelial(112;6.15e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.29e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0516)														---	---	---	---
BUB1B	701	broad.mit.edu	37	15	40504822	40504822	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:40504822C>T	uc001zkx.3	+	19	2720	c.2508C>T	c.(2506-2508)CAC>CAT	p.H836H		NM_001211	NP_001202	O60566	BUB1B_HUMAN	budding uninhibited by benzimidazoles 1 beta	836	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|kidney(1)	4		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)				Mis|N|F|S			rhabdomyosarcoma			Mosaic_Variegated_Aneuploidy_Syndrome				---	---	---	---
VPS18	57617	broad.mit.edu	37	15	41191717	41191717	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:41191717G>A	uc001zne.2	+	4	1040	c.701G>A	c.(700-702)CGA>CAA	p.R234Q		NM_020857	NP_065908	Q9P253	VPS18_HUMAN	vacuolar protein sorting 18	234					endosome organization|lysosome organization|protein transport	HOPS complex|late endosome membrane|lysosomal membrane	metal ion binding|protein binding			ovary(2)|large_intestine(1)	3		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)														---	---	---	---
VPS18	57617	broad.mit.edu	37	15	41192111	41192111	+	Silent	SNP	G	A	A	rs140464667	byFrequency;by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:41192111G>A	uc001zne.2	+	4	1434	c.1095G>A	c.(1093-1095)CCG>CCA	p.P365P		NM_020857	NP_065908	Q9P253	VPS18_HUMAN	vacuolar protein sorting 18	365					endosome organization|lysosome organization|protein transport	HOPS complex|late endosome membrane|lysosomal membrane	metal ion binding|protein binding			ovary(2)|large_intestine(1)	3		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)														---	---	---	---
VPS18	57617	broad.mit.edu	37	15	41192635	41192635	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:41192635G>A	uc001zne.2	+	4	1958	c.1619G>A	c.(1618-1620)CGG>CAG	p.R540Q		NM_020857	NP_065908	Q9P253	VPS18_HUMAN	vacuolar protein sorting 18	540					endosome organization|lysosome organization|protein transport	HOPS complex|late endosome membrane|lysosomal membrane	metal ion binding|protein binding			ovary(2)|large_intestine(1)	3		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)														---	---	---	---
MGA	23269	broad.mit.edu	37	15	42041783	42041783	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:42041783T>G	uc010ucy.1	+	17	6159	c.5978T>G	c.(5977-5979)GTT>GGT	p.V1993G	MGA_uc010ucz.1_Missense_Mutation_p.V1784G|MGA_uc010uda.1_Missense_Mutation_p.V609G|MGA_uc001zoi.2_Missense_Mutation_p.V207G	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	1954	Basic motif.					MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)														---	---	---	---
TTBK2	146057	broad.mit.edu	37	15	43094122	43094122	+	Intron	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:43094122C>T	uc001zqo.2	-						TTBK2_uc010bcy.2_Intron|TTBK2_uc001zqp.2_Intron|TTBK2_uc010bcz.1_Intron	NM_173500	NP_775771			tau tubulin kinase 2						cell death		ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|stomach(1)|pancreas(1)|skin(1)	7		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)														---	---	---	---
SERINC4	619189	broad.mit.edu	37	15	44087241	44087241	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:44087241C>T	uc010bds.1	-	9	1250	c.782G>A	c.(781-783)CGC>CAC	p.R261H	ELL3_uc001zsx.1_Intron|SERF2_uc010uee.1_3'UTR|C15orf63_uc001ztb.2_Intron|SERF2_uc001zsz.3_3'UTR|MIR1282_hsa-mir-1282|MI0006429_5'Flank|SERINC4_uc001ztc.1_RNA|SERINC4_uc001ztd.1_3'UTR|SERINC4_uc001zte.1_Missense_Mutation_p.R261H	NM_001033517	NP_001028689	A6NH21	SERC4_HUMAN	serine incorporator 4	505					phospholipid biosynthetic process	integral to membrane					0		all_cancers(109;3.26e-11)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.61e-06)|all_lung(180;1.5e-05)|Melanoma(134;0.0417)		GBM - Glioblastoma multiforme(94;7.81e-07)														---	---	---	---
C15orf43	145645	broad.mit.edu	37	15	45249094	45249094	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:45249094T>C	uc001zuk.2	+	2	82	c.65T>C	c.(64-66)GTG>GCG	p.V22A		NM_152448	NP_689661	Q8NHR7	CO043_HUMAN	hypothetical protein LOC145645	22											0		all_cancers(109;3.68e-08)|all_epithelial(112;1.05e-06)|Lung NSC(122;1.42e-05)|all_lung(180;0.000112)|Melanoma(134;0.0192)		all cancers(107;7.64e-17)|GBM - Glioblastoma multiforme(94;2.03e-06)														---	---	---	---
CEP152	22995	broad.mit.edu	37	15	49030679	49030679	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:49030679G>A	uc001zwy.2	-	26	4766	c.4732C>T	c.(4732-4734)CGT>TGT	p.R1578C	CEP152_uc001zwz.2_Missense_Mutation_p.R1634C	NM_014985	NP_055800	O94986	CE152_HUMAN	centrosomal protein 152kDa	1578					centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			lung(2)	2		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)														---	---	---	---
HDC	3067	broad.mit.edu	37	15	50534778	50534778	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:50534778C>T	uc001zxz.2	-	12	1774	c.1668G>A	c.(1666-1668)GAG>GAA	p.E556E	HDC_uc001zxy.2_Silent_p.E299E|HDC_uc010uff.1_Silent_p.E523E	NM_002112	NP_002103	P19113	DCHS_HUMAN	histidine decarboxylase	556					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)													---	---	---	---
CYP19A1	1588	broad.mit.edu	37	15	51504657	51504657	+	Missense_Mutation	SNP	G	A	A	rs121434536		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:51504657G>A	uc001zyz.3	-	10	1374	c.1123C>T	c.(1123-1125)CGC>TGC	p.R375C	CYP19A1_uc001zza.3_Missense_Mutation_p.R375C|CYP19A1_uc001zzb.2_Missense_Mutation_p.R375C	NM_031226	NP_112503	P11511	CP19A_HUMAN	cytochrome P450, family 19	375			R -> L.|R -> C (in AROD).		estrogen biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|membrane fraction	aromatase activity|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(3)	3				all cancers(107;0.000372)|GBM - Glioblastoma multiforme(94;0.0128)	Aminoglutethimide(DB00357)|Anastrozole(DB01217)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Diethylstilbestrol(DB00255)|Exemestane(DB00990)|Letrozole(DB01006)|Testolactone(DB00894)|Testosterone(DB00624)													---	---	---	---
LEO1	123169	broad.mit.edu	37	15	52244164	52244164	+	Silent	SNP	C	T	T	rs142218056		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:52244164C>T	uc002abo.2	-	9	1504	c.1488G>A	c.(1486-1488)ACG>ACA	p.T496T	LEO1_uc010bfd.2_Silent_p.T436T	NM_138792	NP_620147	Q8WVC0	LEO1_HUMAN	Leo1, Paf1/RNA polymerase II complex component,	496					histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding				0				all cancers(107;0.00264)														---	---	---	---
MYO5A	4644	broad.mit.edu	37	15	52606371	52606371	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:52606371T>C	uc002aby.2	-	40	5608	c.5364A>G	c.(5362-5364)CCA>CCG	p.P1788P	MYO5A_uc002abx.3_Silent_p.P1761P|MYO5A_uc010ugd.1_Silent_p.P510P	NM_000259	NP_000250	Q9Y4I1	MYO5A_HUMAN	myosin VA isoform 1	1788	Dilute.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|central_nervous_system(1)	4				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)														---	---	---	---
UNC13C	440279	broad.mit.edu	37	15	54528622	54528622	+	Intron	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:54528622C>A	uc002ack.2	+							NM_001080534	NP_001074003			unc-13 homolog C						exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)														---	---	---	---
UNC13C	440279	broad.mit.edu	37	15	54586261	54586261	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:54586261A>C	uc002ack.2	+	9	3987	c.3987A>C	c.(3985-3987)TTA>TTC	p.L1329F	UNC13C_uc002acl.2_Missense_Mutation_p.L159F	NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1329					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)														---	---	---	---
TLN2	83660	broad.mit.edu	37	15	63044602	63044602	+	Nonsense_Mutation	SNP	T	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:63044602T>A	uc002alb.3	+	32	4308	c.4308T>A	c.(4306-4308)TGT>TGA	p.C1436*	TLN2_uc002alc.3_5'UTR	NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	1436					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11																		---	---	---	---
TLN2	83660	broad.mit.edu	37	15	63053883	63053883	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:63053883C>A	uc002alb.3	+	35	4642	c.4642C>A	c.(4642-4644)CTG>ATG	p.L1548M	TLN2_uc002alc.3_Translation_Start_Site|TLN2_uc002ald.2_Translation_Start_Site	NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	1548					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11																		---	---	---	---
TPM1	7168	broad.mit.edu	37	15	63356328	63356328	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:63356328G>A	uc002alg.2	+	9	1029	c.838G>A	c.(838-840)GAT>AAT	p.D280N	TPM1_uc002alh.2_Missense_Mutation_p.D280N|TPM1_uc010bgn.2_Intron|TPM1_uc002ali.2_Intron|TPM1_uc002alj.2_Intron|TPM1_uc002alk.2_Intron|TPM1_uc002all.2_Intron|TPM1_uc002alm.2_Intron|TPM1_uc010uie.1_Missense_Mutation_p.D280N|TPM1_uc002alp.2_Missense_Mutation_p.D280N|TPM1_uc002alr.2_Intron|TPM1_uc002als.2_Intron|TPM1_uc010uig.1_Intron|TPM1_uc002alt.2_Intron|TPM1_uc010bgp.2_Intron	NM_001018005	NP_001018005	P09493	TPM1_HUMAN	tropomyosin 1 alpha chain isoform 1	280	By similarity.				cardiac muscle contraction|cellular component movement|cellular response to reactive oxygen species|muscle filament sliding|negative regulation of cell migration|positive regulation of ATPase activity|positive regulation of cell adhesion|positive regulation of heart rate by epinephrine|positive regulation of stress fiber assembly|regulation of muscle contraction|ruffle organization|sarcomere organization|ventricular cardiac muscle tissue morphogenesis|wound healing	bleb|cytosol|muscle thin filament tropomyosin|ruffle membrane|stress fiber	actin binding|structural constituent of cytoskeleton|structural constituent of muscle				0																		---	---	---	---
ZNF609	23060	broad.mit.edu	37	15	64792134	64792134	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:64792134C>T	uc002ann.2	+	1	516	c.516C>T	c.(514-516)AGC>AGT	p.S172S	ZNF609_uc010bgy.2_Silent_p.S172S	NM_015042	NP_055857	O15014	ZN609_HUMAN	zinc finger protein 609	172						nucleus	zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3																		---	---	---	---
PIF1	80119	broad.mit.edu	37	15	65110214	65110214	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:65110214C>T	uc002ant.2	-	11	1671	c.1605G>A	c.(1603-1605)GGG>GGA	p.G535G	PIF1_uc002anr.2_Silent_p.G83G|PIF1_uc002ans.2_Silent_p.G226G|PIF1_uc010uiq.1_Silent_p.G535G	NM_025049	NP_079325	Q9H611	PIF1_HUMAN	DNA helicase homolog PIF1	535	Hydrolyzes ATP in the presence of both magnesium and single-stranded DNA; weak activity in the presence of RNA or double-stranded DNA; No unwinding activity.				negative regulation of telomerase activity|regulation of telomere maintenance|viral genome replication	nuclear chromosome, telomeric region	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' DNA/RNA helicase activity|magnesium ion binding|single-stranded DNA-dependent ATP-dependent DNA helicase activity|telomeric DNA binding				0																		---	---	---	---
CORO2B	10391	broad.mit.edu	37	15	69011561	69011561	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:69011561G>T	uc002arj.3	+	10	1188	c.1159G>T	c.(1159-1161)GGC>TGC	p.G387C	CORO2B_uc010bic.2_Missense_Mutation_p.G382C|CORO2B_uc002ark.2_Missense_Mutation_p.G154C	NM_006091	NP_006082	Q9UQ03	COR2B_HUMAN	coronin, actin binding protein, 2B	387					actin cytoskeleton organization	actin cytoskeleton|cytoplasm|membrane	actin filament binding			ovary(3)|skin(2)|large_intestine(1)	6																		---	---	---	---
KIF23	9493	broad.mit.edu	37	15	69733281	69733281	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:69733281C>T	uc002asb.2	+	18	2359	c.2242C>T	c.(2242-2244)CGT>TGT	p.R748C	KIF23_uc002asc.2_Intron|KIF23_uc010bii.2_Missense_Mutation_p.R638C|KIF23_uc010ukc.1_Intron	NM_138555	NP_612565	Q02241	KIF23_HUMAN	kinesin family member 23 isoform 1	748					blood coagulation|cytokinesis|microtubule-based movement|mitosis|mitotic spindle elongation	cytosol|kinesin complex|microtubule|midbody|nucleoplasm|spindle	ATP binding|microtubule motor activity|protein binding				0																		---	---	---	---
ARIH1	25820	broad.mit.edu	37	15	72873215	72873215	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:72873215T>C	uc002aut.3	+	12	1673	c.1359T>C	c.(1357-1359)ATT>ATC	p.I453I		NM_005744	NP_005735	Q9Y4X5	ARI1_HUMAN	ariadne ubiquitin-conjugating enzyme E2 binding	453					ubiquitin-dependent protein catabolic process	cytoplasm|ubiquitin ligase complex	ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding				0																		---	---	---	---
ISLR	3671	broad.mit.edu	37	15	74467395	74467395	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:74467395C>A	uc002axg.1	+	2	478	c.196C>A	c.(196-198)CCG>ACG	p.P66T	ISLR_uc002axh.1_Missense_Mutation_p.P66T	NM_005545	NP_005536	O14498	ISLR_HUMAN	immunoglobulin superfamily containing	66	LRR 1.				cell adhesion	extracellular region				large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4																		---	---	---	---
CLK3	1198	broad.mit.edu	37	15	74920982	74920982	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:74920982A>C	uc010uln.1	+	11	2068	c.1607A>C	c.(1606-1608)AAG>ACG	p.K536T	CLK3_uc002ayg.3_Missense_Mutation_p.K388T|CLK3_uc002ayh.3_Missense_Mutation_p.K167T|CLK3_uc002ayj.3_Missense_Mutation_p.K365T|CLK3_uc002ayk.3_Missense_Mutation_p.K315T|CLK3_uc002ayl.3_Missense_Mutation_p.K221T	NM_001130028	NP_001123500	P49761	CLK3_HUMAN	CDC-like kinase 3 isoform a	536	Protein kinase.					acrosomal vesicle|nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(2)	2																		---	---	---	---
SIN3A	25942	broad.mit.edu	37	15	75664509	75664509	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:75664509C>A	uc002bai.2	-	21	3892	c.3633G>T	c.(3631-3633)CAG>CAT	p.Q1211H	SIN3A_uc002baj.2_Missense_Mutation_p.Q1211H|SIN3A_uc010uml.1_Missense_Mutation_p.Q1211H	NM_015477	NP_056292	Q96ST3	SIN3A_HUMAN	transcriptional co-repressor Sin3A	1211					blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			skin(3)|ovary(1)|lung(1)	5																		---	---	---	---
SGK269	79834	broad.mit.edu	37	15	77471360	77471360	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:77471360C>T	uc002bcm.2	-	3	3217	c.2909G>A	c.(2908-2910)CGC>CAC	p.R970H	SGK269_uc002bcn.2_Missense_Mutation_p.R970H	NM_024776	NP_079052	Q9H792	PEAK1_HUMAN	NKF3 kinase family member	970					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding				0				STAD - Stomach adenocarcinoma(199;0.124)														---	---	---	---
CHRNA3	1136	broad.mit.edu	37	15	78894269	78894269	+	Missense_Mutation	SNP	G	A	A	rs61737495		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:78894269G>A	uc002bec.2	-	5	901	c.715C>T	c.(715-717)CGC>TGC	p.R239C	CHRNA3_uc002bea.2_RNA|CHRNA3_uc002beb.2_Missense_Mutation_p.R239C	NM_000743	NP_000734	P32297	ACHA3_HUMAN	cholinergic receptor, nicotinic, alpha 3	239	Extracellular (Potential).				activation of transmembrane receptor protein tyrosine kinase activity|behavioral response to nicotine|locomotory behavior|regulation of acetylcholine secretion|regulation of dendrite morphogenesis|regulation of excitatory postsynaptic membrane potential|regulation of smooth muscle contraction|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|dendrite|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic density|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(3)|ovary(1)	4																		---	---	---	---
KIAA1199	57214	broad.mit.edu	37	15	81176550	81176550	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:81176550C>T	uc002bfw.1	+	6	912	c.652C>T	c.(652-654)CGT>TGT	p.R218C	KIAA1199_uc010unn.1_Missense_Mutation_p.R218C	NM_018689	NP_061159	Q8WUJ3	K1199_HUMAN	KIAA1199 precursor	218										upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3																		---	---	---	---
EFTUD1	79631	broad.mit.edu	37	15	82444436	82444436	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:82444436C>T	uc002bgt.1	-	18	2528	c.2359G>A	c.(2359-2361)GAA>AAA	p.E787K	EFTUD1_uc002bgs.1_Missense_Mutation_p.E158K|EFTUD1_uc002bgu.1_Missense_Mutation_p.E736K	NM_024580	NP_078856	Q7Z2Z2	ETUD1_HUMAN	elongation factor Tu GTP binding domain	787					mature ribosome assembly		GTP binding|GTPase activity|ribosome binding|translation elongation factor activity			ovary(1)	1																		---	---	---	---
FSD2	123722	broad.mit.edu	37	15	83451733	83451733	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:83451733G>A	uc002bjd.2	-	4	947	c.780C>T	c.(778-780)AAC>AAT	p.N260N	FSD2_uc010uol.1_Silent_p.N260N|FSD2_uc010uom.1_Silent_p.N260N	NM_001007122	NP_001007123	A1L4K1	FSD2_HUMAN	fibronectin type III and SPRY domain containing	260	Potential.									central_nervous_system(1)	1																		---	---	---	---
WHAMM	123720	broad.mit.edu	37	15	83499687	83499687	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:83499687C>T	uc002bje.2	+	9	2484	c.1978C>T	c.(1978-1980)CGT>TGT	p.R660C		NM_001080435	NP_001073904	Q8TF30	WHAMM_HUMAN	WAS protein homolog associated with actin, golgi	660						cytoplasmic vesicle membrane|ER-Golgi intermediate compartment|Golgi apparatus	actin binding				0																		---	---	---	---
ZNF592	9640	broad.mit.edu	37	15	85342439	85342439	+	Silent	SNP	C	T	T	rs61746436	byFrequency	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:85342439C>T	uc002bld.2	+	9	3471	c.3135C>T	c.(3133-3135)TGC>TGT	p.C1045C	ZNF592_uc010upb.1_RNA	NM_014630	NP_055445	Q92610	ZN592_HUMAN	zinc finger protein 592	1045	C2H2-type 11; atypical.				cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(2)	6			BRCA - Breast invasive adenocarcinoma(143;0.0587)															---	---	---	---
KLHL25	64410	broad.mit.edu	37	15	86312998	86312998	+	Missense_Mutation	SNP	G	A	A	rs149329403	byFrequency	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:86312998G>A	uc002bly.2	-	2	247	c.44C>T	c.(43-45)ACG>ATG	p.T15M		NM_022480	NP_071925	Q9H0H3	ENC2_HUMAN	BTB/POZ KELCH domain protein	15						cytoplasm				ovary(2)	2																		---	---	---	---
AEN	64782	broad.mit.edu	37	15	89173290	89173290	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:89173290T>C	uc002bmt.2	+	4	894	c.743T>C	c.(742-744)GTG>GCG	p.V248A	AEN_uc010bnm.1_Missense_Mutation_p.V248A	NM_022767	NP_073604	Q8WTP8	AEN_HUMAN	interferon stimulated exonuclease gene	248	Exonuclease.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|response to ionizing radiation	nucleolus|nucleoplasm	exonuclease activity|nucleic acid binding				0																		---	---	---	---
SEMA4B	10509	broad.mit.edu	37	15	90763066	90763066	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:90763066C>T	uc002boy.2	+	5	709	c.426C>T	c.(424-426)AGC>AGT	p.S142S	SEMA4B_uc002boz.2_Silent_p.S142S|SEMA4B_uc010uqd.1_5'UTR|SEMA4B_uc002bpa.2_5'UTR|SEMA4B_uc010bnv.1_5'Flank	NM_020210	NP_064595			semaphorin 4B precursor											ovary(1)|breast(1)|kidney(1)	3	Melanoma(11;0.00551)|Lung NSC(78;0.0125)|all_lung(78;0.0272)		BRCA - Breast invasive adenocarcinoma(143;0.0107)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.217)													OREG0023468	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
IGF1R	3480	broad.mit.edu	37	15	99491899	99491899	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:99491899C>T	uc002bul.2	+	20	3734	c.3684C>T	c.(3682-3684)GGC>GGT	p.G1228G	IGF1R_uc010bon.2_Silent_p.G1227G	NM_000875	NP_000866	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor precursor	1228	Protein kinase.|Cytoplasmic (Potential).				anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			lung(3)|kidney(3)|ovary(1)|central_nervous_system(1)	8	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)													---	---	---	---
ADAMTS17	170691	broad.mit.edu	37	15	100649204	100649204	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:100649204C>T	uc002bvv.1	-	14	2085	c.2006G>A	c.(2005-2007)GGC>GAC	p.G669D	ADAMTS17_uc002bvx.1_Missense_Mutation_p.G426D	NM_139057	NP_620688	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1	669	Cys-rich.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)														---	---	---	---
ADAMTS17	170691	broad.mit.edu	37	15	100692868	100692868	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:100692868C>T	uc002bvv.1	-	10	1501	c.1422G>A	c.(1420-1422)GAG>GAA	p.E474E	ADAMTS17_uc002bvx.1_Silent_p.E231E	NM_139057	NP_620688	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1	474	Disintegrin.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)														---	---	---	---
LRRK1	79705	broad.mit.edu	37	15	101565157	101565157	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:101565157G>T	uc002bwr.2	+	16	2536	c.2217G>T	c.(2215-2217)TGG>TGT	p.W739C	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_RNA	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	739	Roc.				small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)															---	---	---	---
PDIA2	64714	broad.mit.edu	37	16	334457	334457	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:334457C>T	uc002cgn.1	+	7	1378	c.270C>T	c.(268-270)GCC>GCT	p.A90A	PDIA2_uc010bqt.1_5'UTR|PDIA2_uc002cgo.1_Silent_p.A90A	NM_006849	NP_006840	Q13087	PDIA2_HUMAN	protein disulfide isomerase A2 precursor	90	Thioredoxin 1.				apoptosis|cell redox homeostasis|glycerol ether metabolic process|protein folding|protein retention in ER lumen|response to hypoxia	endoplasmic reticulum lumen	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity|steroid binding			central_nervous_system(1)|skin(1)	2		all_cancers(16;6.71e-07)|all_epithelial(16;1.59e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00769)|all_lung(18;0.0186)																---	---	---	---
CCDC78	124093	broad.mit.edu	37	16	774354	774354	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:774354G>A	uc002cjg.2	-	9	1027	c.921C>T	c.(919-921)AGC>AGT	p.S307S	CCDC78_uc002cjf.2_Silent_p.S156S|CCDC78_uc002cji.3_3'UTR|CCDC78_uc002cjj.3_3'UTR|CCDC78_uc002cjh.2_Silent_p.S66S|CCDC78_uc010uuo.1_3'UTR|HAGHL_uc002cjl.1_5'Flank|HAGHL_uc002cjm.1_5'Flank|HAGHL_uc002cjn.1_5'Flank|HAGHL_uc002cjo.1_5'Flank|HAGHL_uc010uup.1_5'Flank	NM_001031737	NP_001026907	A2IDD5	CCD78_HUMAN	coiled-coil domain containing 78	307										central_nervous_system(1)	1		Hepatocellular(780;0.0218)																---	---	---	---
MSLN	10232	broad.mit.edu	37	16	817480	817480	+	Intron	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:817480G>A	uc002cjw.1	+						MSLN_uc002cjt.1_Intron|MSLN_uc002cju.1_Intron|MSLN_uc010brd.1_Intron|MSLN_uc002cjv.1_Intron|MSLN_uc002cjx.1_Intron|MSLN_uc002cjy.1_Intron|MIR662_hsa-mir-662|MI0003670_5'Flank	NM_013404	NP_037536			mesothelin isoform 2 preproprotein						cell adhesion	anchored to membrane|extracellular region|Golgi apparatus|plasma membrane				pancreas(1)	1		Hepatocellular(780;0.00335)																---	---	---	---
CHTF18	63922	broad.mit.edu	37	16	846041	846041	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:846041G>A	uc002cke.3	+	18	2483	c.2420G>A	c.(2419-2421)CGC>CAC	p.R807H	CHTF18_uc002ckf.3_Missense_Mutation_p.R835H|CHTF18_uc010brf.2_Missense_Mutation_p.R389H|CHTF18_uc002ckg.3_Missense_Mutation_p.R325H	NM_022092	NP_071375	Q8WVB6	CTF18_HUMAN	CTF18, chromosome transmission fidelity factor	807					cell cycle|DNA replication	nucleus	ATP binding|DNA binding|nucleoside-triphosphatase activity			kidney(1)	1		Hepatocellular(780;0.00335)																---	---	---	---
CACNA1H	8912	broad.mit.edu	37	16	1255203	1255203	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:1255203C>T	uc002cks.2	+	11	2789	c.2541C>T	c.(2539-2541)TGC>TGT	p.C847C	CACNA1H_uc002ckt.2_Silent_p.C847C	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	847	II.|Helical; Name=S2 of repeat II; (Potential).				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)													---	---	---	---
CACNA1H	8912	broad.mit.edu	37	16	1257402	1257402	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:1257402C>T	uc002cks.2	+	14	3283	c.3035C>T	c.(3034-3036)GCC>GTC	p.A1012V	CACNA1H_uc002ckt.2_Missense_Mutation_p.A1012V|CACNA1H_uc002cku.2_5'Flank|CACNA1H_uc010brj.2_5'Flank|CACNA1H_uc002ckv.2_5'Flank	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	1012	II.|Helical; Name=S6 of repeat II; (Potential).				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)													---	---	---	---
PKD1	5310	broad.mit.edu	37	16	2140354	2140354	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2140354C>T	uc002cos.1	-	45	12585	c.12376G>A	c.(12376-12378)GAC>AAC	p.D4126N	PKD1_uc002cot.1_Missense_Mutation_p.D4125N|MIR1225_hsa-mir-1225|MI0006311_5'Flank	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	4126	Cytoplasmic (Potential).				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3																		---	---	---	---
PKD1	5310	broad.mit.edu	37	16	2150160	2150160	+	Intron	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2150160G>A	uc002cos.1	-						PKD1_uc002cot.1_Intron|PKD1_uc010bse.1_Intron	NM_001009944	NP_001009944			polycystin 1 isoform 1 precursor						calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3																		---	---	---	---
PKD1	5310	broad.mit.edu	37	16	2164381	2164381	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2164381G>A	uc002cos.1	-	11	2852	c.2643C>T	c.(2641-2643)TTC>TTT	p.F881F	PKD1_uc002cot.1_Silent_p.F881F	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	881	Extracellular (Potential).|PKD 3.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3																		---	---	---	---
E4F1	1877	broad.mit.edu	37	16	2282806	2282806	+	Silent	SNP	G	A	A	rs139438270	byFrequency;by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2282806G>A	uc002cpm.2	+	6	828	c.780G>A	c.(778-780)TCG>TCA	p.S260S	E4F1_uc010bsi.2_Silent_p.S260S|E4F1_uc010bsj.2_Silent_p.S260S	NM_004424	NP_004415	Q66K89	E4F1_HUMAN	p120E4F	260	Mediates dimerization, DNA-binding, transcription repression of CCNA2 and interaction with HMGA2.|C2H2-type 3; degenerate.				cell division|cell proliferation|interspecies interaction between organisms|mitosis|regulation of growth	cytoplasm|nucleoplasm	DNA binding|ligase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)	1																		---	---	---	---
THOC6	79228	broad.mit.edu	37	16	3077501	3077501	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3077501G>A	uc002ctb.2	+	12	1241	c.945G>A	c.(943-945)AAG>AAA	p.K315K	THOC6_uc002ctd.2_Intron|THOC6_uc002ctc.2_Silent_p.K291K|THOC6_uc002cta.2_Silent_p.K291K	NM_024339	NP_077315	Q86W42	THOC6_HUMAN	WD repeat domain 58 isoform 1	315	WD 7.				intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	RNA binding			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
IL32	9235	broad.mit.edu	37	16	3115808	3115808	+	5'UTR	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3115808C>T	uc002cto.2	+	2					IL32_uc002ctk.2_5'UTR|IL32_uc010uwp.1_5'UTR|IL32_uc010btb.2_Intron|IL32_uc002ctl.2_5'UTR|IL32_uc002ctm.2_5'UTR|IL32_uc002ctn.2_5'UTR|IL32_uc010btc.1_5'UTR|IL32_uc002cts.3_5'UTR|IL32_uc002ctp.2_5'UTR|IL32_uc010uwq.1_5'UTR|IL32_uc002ctq.2_5'UTR|IL32_uc002ctr.2_5'UTR|IL32_uc002ctt.2_5'UTR|IL32_uc010uwr.1_5'UTR|IL32_uc002ctu.2_5'UTR	NM_004221	NP_004212			interleukin 32 isoform B						cell adhesion|defense response|immune response	extracellular space	cytokine activity			pancreas(1)	1																		---	---	---	---
ZSCAN10	84891	broad.mit.edu	37	16	3139421	3139421	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3139421G>A	uc002ctv.1	-	5	1937	c.1849C>T	c.(1849-1851)CGC>TGC	p.R617C	ZSCAN10_uc002cty.1_Missense_Mutation_p.R278C|ZSCAN10_uc002ctw.1_Missense_Mutation_p.R535C|ZSCAN10_uc002ctx.1_Missense_Mutation_p.R545C	NM_032805	NP_116194	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	617	C2H2-type 11.				negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1																		---	---	---	---
CLUAP1	23059	broad.mit.edu	37	16	3562425	3562425	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3562425A>G	uc002cvk.1	+	5	547	c.442A>G	c.(442-444)ACC>GCC	p.T148A	CLUAP1_uc002cvj.1_Missense_Mutation_p.T148A|CLUAP1_uc002cvl.1_Missense_Mutation_p.T148A|CLUAP1_uc002cvm.1_Intron	NM_015041	NP_055856	Q96AJ1	CLUA1_HUMAN	clusterin associated protein 1 isoform 1	148						nucleus	protein binding			ovary(1)|breast(1)|pancreas(1)	3																		---	---	---	---
TRAP1	10131	broad.mit.edu	37	16	3740865	3740865	+	Silent	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3740865G>T	uc002cvt.3	-	2	299	c.210C>A	c.(208-210)CCC>CCA	p.P70P	TRAP1_uc010uxf.1_Intron	NM_016292	NP_057376	Q12931	TRAP1_HUMAN	TNF receptor-associated protein 1 precursor	70					cellular response to oxidative stress|protein folding	mitochondrion	ATP binding|tumor necrosis factor receptor binding|unfolded protein binding			central_nervous_system(1)	1		Ovarian(90;0.0261)														OREG0023572	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
SRL	6345	broad.mit.edu	37	16	4292031	4292031	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:4292031G>A	uc002cvz.3	-	1	51	c.38C>T	c.(37-39)TCG>TTG	p.S13L	SRL_uc002cvy.3_RNA	NM_001098814	NP_001092284	Q86TD4	SRCA_HUMAN	sarcalumenin	13						sarcoplasmic reticulum lumen	GTP binding|GTPase activity			ovary(3)|skin(2)	5																		---	---	---	---
UBN1	29855	broad.mit.edu	37	16	4924216	4924216	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:4924216C>T	uc002cyb.2	+	15	2144	c.1805C>T	c.(1804-1806)TCG>TTG	p.S602L	UBN1_uc010uxw.1_Missense_Mutation_p.S602L|UBN1_uc002cyc.2_Missense_Mutation_p.S602L	NM_001079514	NP_001072982	Q9NPG3	UBN1_HUMAN	ubinuclein 1	602					chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2																		---	---	---	---
UBN1	29855	broad.mit.edu	37	16	4925259	4925259	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:4925259G>A	uc002cyb.2	+	15	3187	c.2848G>A	c.(2848-2850)GTC>ATC	p.V950I	UBN1_uc010uxw.1_Missense_Mutation_p.V950I|UBN1_uc002cyc.2_Missense_Mutation_p.V950I	NM_001079514	NP_001072982	Q9NPG3	UBN1_HUMAN	ubinuclein 1	950	Ser-rich.				chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2																		---	---	---	---
PPL	5493	broad.mit.edu	37	16	4943363	4943363	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:4943363C>T	uc002cyd.1	-	14	1591	c.1501G>A	c.(1501-1503)GAC>AAC	p.D501N		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	501					keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6																		---	---	---	---
ALG1	56052	broad.mit.edu	37	16	5129739	5129739	+	Intron	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:5129739C>T	uc002cym.2	+						ALG1_uc002cyj.2_Intron|ALG1_uc002cyn.2_Intron|ALG1_uc010bue.2_Intron|ALG1_uc010uxy.1_Intron	NM_019109	NP_061982			beta-1,4-mannosyltransferase						dolichol-linked oligosaccharide biosynthetic process|lipopolysaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	chitobiosyldiphosphodolichol beta-mannosyltransferase activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(90;0.0164)																---	---	---	---
C16orf68	79091	broad.mit.edu	37	16	8722842	8722842	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:8722842C>T	uc002cyz.2	+	3	665	c.389C>T	c.(388-390)GCC>GTC	p.A130V	C16orf68_uc002cza.2_Intron	NM_024109	NP_077014	Q9BUU2	MET22_HUMAN	hypothetical protein LOC79091	130							methyltransferase activity				0																		---	---	---	---
C16orf75	116028	broad.mit.edu	37	16	11367459	11367459	+	Intron	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:11367459C>T	uc002daq.1	+						PRM3_uc002dat.1_5'Flank					Homo sapiens cDNA FLJ41770 fis, clone IMR322007225.						DNA replication	nucleus	DNA binding				0								T	CIITA	PMBL|Hodgkin Lymphona|								---	---	---	---
BFAR	51283	broad.mit.edu	37	16	14738469	14738469	+	Intron	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:14738469A>G	uc002dco.2	+						BFAR_uc002dcm.2_Intron|BFAR_uc002dcn.2_Intron|BFAR_uc002dcp.2_Intron|BFAR_uc010uzh.1_Intron	NM_016561	NP_057645			bifunctional apoptosis regulator						anti-apoptosis|apoptosis	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	structural molecule activity|zinc ion binding			ovary(1)|skin(1)	2																		---	---	---	---
KIAA0430	9665	broad.mit.edu	37	16	15719582	15719582	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:15719582G>A	uc002ddr.2	-	8	1793	c.1600C>T	c.(1600-1602)CGC>TGC	p.R534C	KIAA0430_uc002ddq.2_Intron|KIAA0430_uc010uzv.1_Missense_Mutation_p.R530C|KIAA0430_uc010uzw.1_Missense_Mutation_p.R532C	NM_014647	NP_055462	Q9Y4F3	LKAP_HUMAN	limkain b1	533						peroxisome	nucleotide binding|RNA binding				0																		---	---	---	---
ABCC6	368	broad.mit.edu	37	16	16291913	16291913	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:16291913C>T	uc002den.3	-	10	1340	c.1303G>A	c.(1303-1305)GTC>ATC	p.V435I	ABCC6_uc010bvo.2_RNA|ABCC6_uc010uzz.1_Missense_Mutation_p.V447I	NM_001171	NP_001162	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C, member 6	435	ABC transmembrane type-1 1.|Helical; Name=8; (By similarity).				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)														---	---	---	---
XYLT1	64131	broad.mit.edu	37	16	17202787	17202787	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:17202787G>A	uc002dfa.2	-	12	2730	c.2645C>T	c.(2644-2646)CCC>CTC	p.P882L		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	882	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4																		---	---	---	---
ARL6IP1	23204	broad.mit.edu	37	16	18806827	18806827	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:18806827A>G	uc002dfl.1	-	4	436	c.367T>C	c.(367-369)TGG>CGG	p.W123R	ARL6IP1_uc010van.1_Missense_Mutation_p.W94R|ARL6IP1_uc010bvz.1_Intron	NM_015161	NP_055976	Q15041	AR6P1_HUMAN	ADP-ribosylation factor-like 6 interacting	123						integral to membrane	protein binding				0																		---	---	---	---
TMC7	79905	broad.mit.edu	37	16	19033117	19033117	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:19033117G>T	uc002dfq.2	+	4	757	c.627G>T	c.(625-627)ATG>ATT	p.M209I	TMC7_uc010vao.1_Missense_Mutation_p.M209I|TMC7_uc002dfp.2_Missense_Mutation_p.M209I|TMC7_uc010vap.1_Missense_Mutation_p.M99I	NM_024847	NP_079123	Q7Z402	TMC7_HUMAN	transmembrane channel-like 7 isoform a	209	Cytoplasmic (Potential).					integral to membrane				skin(2)|ovary(1)	3																		---	---	---	---
TMC5	79838	broad.mit.edu	37	16	19477564	19477564	+	Intron	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:19477564G>A	uc002dgc.3	+						TMC5_uc010vaq.1_Intron|TMC5_uc002dgb.3_Intron|TMC5_uc010var.1_Intron|TMC5_uc002dgd.1_Intron|TMC5_uc002dge.3_Intron|TMC5_uc002dgf.3_Intron|TMC5_uc002dgg.3_Intron	NM_001105248	NP_001098718			transmembrane channel-like 5 isoform a							integral to membrane				skin(1)	1																		---	---	---	---
DNAH3	55567	broad.mit.edu	37	16	21109957	21109957	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:21109957G>A	uc010vbe.1	-	17	2500	c.2500C>T	c.(2500-2502)CGG>TGG	p.R834W		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	834	Stem (By similarity).|Potential.				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)														---	---	---	---
ANKS4B	257629	broad.mit.edu	37	16	21245076	21245076	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:21245076C>T	uc010bwp.1	+	1	61	c.18C>T	c.(16-18)CAC>CAT	p.H6H		NM_145865	NP_665872	Q8N8V4	ANS4B_HUMAN	harmonin-interacting ankyrin-repeat containing	6										ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0565)														---	---	---	---
METTL9	51108	broad.mit.edu	37	16	21624076	21624076	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:21624076G>A	uc002dje.2	+	2	475	c.276G>A	c.(274-276)TCG>TCA	p.S92S	uc002diq.3_Intron|METTL9_uc002djf.2_Silent_p.S92S	NM_016025	NP_057109	Q9H1A3	METL9_HUMAN	methyltransferase like 9 isoform 1	92										ovary(1)	1				GBM - Glioblastoma multiforme(48;0.0759)														---	---	---	---
USP31	57478	broad.mit.edu	37	16	23119471	23119471	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:23119471C>T	uc002dll.2	-	2	667	c.667G>A	c.(667-669)GGA>AGA	p.G223R		NM_020718	NP_065769	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	223					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(3)|lung(3)|breast(2)|pancreas(1)|skin(1)	10				GBM - Glioblastoma multiforme(48;0.0187)														---	---	---	---
RBBP6	5930	broad.mit.edu	37	16	24582802	24582802	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:24582802A>T	uc002dmh.2	+	18	5455	c.4415A>T	c.(4414-4416)GAC>GTC	p.D1472V	RBBP6_uc002dmi.2_Missense_Mutation_p.D1438V|RBBP6_uc010bxr.2_Missense_Mutation_p.D632V|RBBP6_uc002dmk.2_Missense_Mutation_p.D1305V	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	1472	Interaction with p53 (By similarity).				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)														---	---	---	---
TNRC6A	27327	broad.mit.edu	37	16	24817979	24817979	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:24817979C>T	uc002dmm.2	+	17	4528	c.4414C>T	c.(4414-4416)CCA>TCA	p.P1472S	TNRC6A_uc010bxs.2_Missense_Mutation_p.P1219S|TNRC6A_uc002dmn.2_Missense_Mutation_p.P1170S|TNRC6A_uc002dmo.2_Missense_Mutation_p.P1111S|TNRC6A_uc002dmp.2_Missense_Mutation_p.P73S|TNRC6A_uc002dmq.2_Missense_Mutation_p.P139S	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1472					negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)														---	---	---	---
ZKSCAN2	342357	broad.mit.edu	37	16	25258441	25258441	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:25258441C>T	uc002dod.3	-	5	1483	c.1076G>A	c.(1075-1077)CGC>CAC	p.R359H	ZKSCAN2_uc010vcl.1_Missense_Mutation_p.R155H|ZKSCAN2_uc002doe.2_Missense_Mutation_p.R359H	NM_001012981	NP_001012999	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	359					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|breast(1)	4				GBM - Glioblastoma multiforme(48;0.0378)														---	---	---	---
CD19	930	broad.mit.edu	37	16	28943679	28943679	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:28943679C>T	uc002drs.2	+	2	163	c.101C>T	c.(100-102)GCT>GTT	p.A34V	uc010vct.1_Intron|CD19_uc010byo.1_Missense_Mutation_p.A34V	NM_001770	NP_001761	P15391	CD19_HUMAN	CD19 antigen precursor	34	Extracellular (Potential).|Ig-like C2-type 1.				cellular defense response	external side of plasma membrane|integral to plasma membrane	protein binding|receptor signaling protein activity			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
MAZ	4150	broad.mit.edu	37	16	29820043	29820043	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:29820043C>T	uc002dty.2	+	4	1428	c.1260C>T	c.(1258-1260)GTC>GTT	p.V420V	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MAZ_uc002dtv.1_Intron|MAZ_uc010vdx.1_Silent_p.V397V|MAZ_uc002dtw.2_Intron|MAZ_uc002dtx.2_Silent_p.V420V|MAZ_uc010bzg.2_Silent_p.V115V|MAZ_uc002dtz.1_3'UTR|MAZ_uc002dua.2_Silent_p.V21V|MAZ_uc010vdy.1_Silent_p.V21V|uc002duc.1_RNA	NM_002383	NP_002374	P56270	MAZ_HUMAN	MYC-associated zinc finger protein isoform 1	420					regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription|transcription initiation from RNA polymerase II promoter	nucleus	DNA binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1																		---	---	---	---
SEZ6L2	26470	broad.mit.edu	37	16	29888190	29888190	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:29888190C>T	uc002duq.3	-	12	2231	c.1991G>A	c.(1990-1992)CGG>CAG	p.R664Q	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Missense_Mutation_p.R594Q|SEZ6L2_uc002dur.3_Missense_Mutation_p.R594Q|SEZ6L2_uc002dus.3_Missense_Mutation_p.R550Q|SEZ6L2_uc010vec.1_Missense_Mutation_p.R664Q|SEZ6L2_uc010ved.1_Missense_Mutation_p.R620Q	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform	664	Sushi 3.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2																		---	---	---	---
ASPHD1	253982	broad.mit.edu	37	16	29913086	29913086	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:29913086G>A	uc002dut.2	+	1	940	c.794G>A	c.(793-795)TGC>TAC	p.C265Y	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_5'Flank|SEZ6L2_uc002dur.3_5'Flank|SEZ6L2_uc002duq.3_5'Flank|SEZ6L2_uc002dus.3_5'Flank|SEZ6L2_uc010vec.1_5'Flank|SEZ6L2_uc010ved.1_5'Flank|ASPHD1_uc002duu.3_RNA|ASPHD1_uc010bzi.2_RNA	NM_181718	NP_859069	Q5U4P2	ASPH1_HUMAN	aspartate beta-hydroxylase domain containing 1	265	Lumenal (Potential).				peptidyl-amino acid modification	integral to endoplasmic reticulum membrane	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity				0																		---	---	---	---
ITGAL	3683	broad.mit.edu	37	16	30518183	30518183	+	Intron	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:30518183T>C	uc002dyi.3	+						ITGAL_uc002dyj.3_Intron|ITGAL_uc010vev.1_Intron	NM_002209	NP_002200			integrin alpha L isoform a precursor						blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)													---	---	---	---
SRCAP	10847	broad.mit.edu	37	16	30733610	30733610	+	Intron	SNP	A	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:30733610A>T	uc002dze.1	+						SRCAP_uc002dzf.2_Intron|SRCAP_uc002dzg.1_Intron|SRCAP_uc010bzz.1_Intron	NM_006662	NP_006653			Snf2-related CBP activator protein						interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)															---	---	---	---
SRCAP	10847	broad.mit.edu	37	16	30749660	30749660	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:30749660C>T	uc002dze.1	+	34	8684	c.8299C>T	c.(8299-8301)CGG>TGG	p.R2767W	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.R2562W	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	2767	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)															---	---	---	---
BCL7C	9274	broad.mit.edu	37	16	30904250	30904250	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:30904250C>T	uc002dzv.2	-	3	325	c.191G>A	c.(190-192)GGC>GAC	p.G64D	BCL7C_uc002dzt.1_Missense_Mutation_p.G64D|uc002dzu.2_Intron|MIR762_hsa-mir-762|MI0003892_5'Flank	NM_004765	NP_004756	Q8WUZ0	BCL7C_HUMAN	B-cell CLL/lymphoma 7C	64					apoptosis						0			Colorectal(24;0.198)															---	---	---	---
PRSS36	146547	broad.mit.edu	37	16	31154711	31154711	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:31154711G>A	uc002ebd.2	-	8	1111	c.1052C>T	c.(1051-1053)GCG>GTG	p.A351V	PRSS36_uc010vff.1_Missense_Mutation_p.A126V|PRSS36_uc010vfg.1_Missense_Mutation_p.A351V|PRSS36_uc010vfh.1_Missense_Mutation_p.A351V	NM_173502	NP_775773	Q5K4E3	POLS2_HUMAN	protease, serine, 36 precursor	351	Peptidase S1 2.				proteolysis	cytoplasm|proteinaceous extracellular matrix	serine-type endopeptidase activity			ovary(1)	1																		---	---	---	---
FUS	2521	broad.mit.edu	37	16	31196420	31196420	+	Silent	SNP	C	T	T	rs151073460	byFrequency	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:31196420C>T	uc002ebf.2	+	6	767	c.684C>T	c.(682-684)GGC>GGT	p.G228G	FUS_uc002ebe.1_Silent_p.G224G|FUS_uc002ebh.2_Silent_p.G227G|FUS_uc002ebg.2_Missense_Mutation_p.A35V|FUS_uc002ebi.2_Silent_p.G228G|FUS_uc002ebj.2_Missense_Mutation_p.A35V|FUS_uc002ebk.1_5'Flank	NM_004960	NP_004951	P35637	FUS_HUMAN	fusion (involved in t(12;16) in malignant	228	Gly-rich.				cell death|nuclear mRNA splicing, via spliceosome	nucleoplasm	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		FUS/DDIT3(623)|FUS/ERG(163)|FUS/CREB3L2(158)|FUS/CREB3L1(6)|FUS/ATF1(4)|FUS/FEV(2)	soft_tissue(791)|haematopoietic_and_lymphoid_tissue(153)|bone(12)|breast(2)	958		Renal(780;0.000219)|Breast(268;0.00957)|Hepatocellular(780;0.121)		GBM - Glioblastoma multiforme(240;2.31e-05)|Kidney(780;0.000209)				T	DDIT3|ERG|FEV|ATF1|CREB3L2|CREB3L1	liposarcoma|AML|Ewing sarcoma|angiomatoid fibrous histiocytoma|fibromyxoid sarcoma								---	---	---	---
VPS35	55737	broad.mit.edu	37	16	46715400	46715400	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:46715400G>A	uc002eef.3	-	4	311	c.212C>T	c.(211-213)TCT>TTT	p.S71F	VPS35_uc002eed.2_5'Flank|VPS35_uc002eee.2_Missense_Mutation_p.S32F	NM_018206	NP_060676	Q96QK1	VPS35_HUMAN	vacuolar protein sorting 35	71					protein transport|retrograde transport, endosome to Golgi	cytosol|endosome|membrane	protein binding				0		all_cancers(37;7.65e-05)|all_epithelial(9;0.000154)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)																---	---	---	---
ADCY7	113	broad.mit.edu	37	16	50342325	50342325	+	Intron	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:50342325A>G	uc002egd.1	+						ADCY7_uc002egc.1_Intron	NM_001114	NP_001105			adenylate cyclase 7						activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			skin(1)	1		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)													---	---	---	---
BRD7	29117	broad.mit.edu	37	16	50357571	50357571	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:50357571T>A	uc002egf.1	-	13	1437	c.1370A>T	c.(1369-1371)TAT>TTT	p.Y457F	BRD7_uc002ege.1_Missense_Mutation_p.Y457F	NM_013263	NP_037395	Q9NPI1	BRD7_HUMAN	bromodomain containing 7	457					cell cycle|negative regulation of cell proliferation|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of histone acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|nucleus	histone acetyl-lysine binding|p53 binding|transcription coactivator activity|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding				0		all_cancers(37;0.0127)																---	---	---	---
SALL1	6299	broad.mit.edu	37	16	51175249	51175249	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:51175249G>A	uc010vgs.1	-	2	915	c.884C>T	c.(883-885)GCA>GTA	p.A295V	SALL1_uc010vgr.1_Missense_Mutation_p.A198V|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	295	Poly-Ala.				adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)															---	---	---	---
IRX5	10265	broad.mit.edu	37	16	54966406	54966406	+	Intron	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:54966406G>A	uc002ehv.2	+						IRX5_uc010cca.1_Intron|IRX5_uc002ehw.2_Silent_p.P16P	NM_005853	NP_005844			iroquois homeobox protein 5						response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|vitamin D binding				0																		---	---	---	---
IRX6	79190	broad.mit.edu	37	16	55363164	55363164	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:55363164C>T	uc002ehy.2	+	5	1807	c.1274C>T	c.(1273-1275)GCG>GTG	p.A425V	IRX6_uc002ehx.2_Missense_Mutation_p.A425V	NM_024335	NP_077311	P78412	IRX6_HUMAN	iroquois homeobox protein 6	425						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(1)	6																		---	---	---	---
SLC6A2	6530	broad.mit.edu	37	16	55690817	55690817	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:55690817G>A	uc002eif.2	+	2	322	c.211G>A	c.(211-213)GGC>AGC	p.G71S	SLC6A2_uc010ccd.2_Missense_Mutation_p.G71S|SLC6A2_uc002eig.2_Missense_Mutation_p.G71S|SLC6A2_uc002eih.2_Missense_Mutation_p.G71S	NM_001043	NP_001034	P23975	SC6A2_HUMAN	solute carrier family 6 member 2	71	Helical; Name=1; (Potential).				synaptic transmission	integral to plasma membrane|membrane fraction	norepinephrine:sodium symporter activity			lung(4)|ovary(2)|pancreas(2)	8				BRCA - Breast invasive adenocarcinoma(181;0.01)|Kidney(780;0.0267)	Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Atomoxetine(DB00289)|Bethanidine(DB00217)|Bupropion(DB01156)|Clomipramine(DB01242)|Cocaine(DB00907)|Debrisoquin(DB04840)|Desipramine(DB01151)|Diethylpropion(DB00937)|Doxepin(DB01142)|Duloxetine(DB00476)|Ergotamine(DB00696)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Imipramine(DB00458)|Maprotiline(DB00934)|Mazindol(DB00579)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Protriptyline(DB00344)|Reboxetine(DB00234)|Sibutramine(DB01105)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)													---	---	---	---
KATNB1	10300	broad.mit.edu	37	16	57789838	57789838	+	Intron	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:57789838C>T	uc002eml.1	+							NM_005886	NP_005877			katanin p80 subunit B 1						cell division|mitosis|negative regulation of microtubule depolymerization|positive regulation of microtubule depolymerization|protein targeting	katanin complex|microtubule|spindle pole	microtubule binding|protein heterodimerization activity				0		all_neural(199;0.223)																---	---	---	---
CDH8	1006	broad.mit.edu	37	16	61687979	61687979	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:61687979G>A	uc002eog.1	-	12	2185	c.1933C>T	c.(1933-1935)CGG>TGG	p.R645W		NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	645	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)														---	---	---	---
CDH5	1003	broad.mit.edu	37	16	66426078	66426078	+	Missense_Mutation	SNP	G	A	A	rs147523967		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:66426078G>A	uc002eom.3	+	7	1165	c.1009G>A	c.(1009-1011)GTC>ATC	p.V337I	CDH5_uc002eon.1_Missense_Mutation_p.V337I	NM_001795	NP_001786	P33151	CADH5_HUMAN	cadherin 5, type 2 preproprotein	337	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)														---	---	---	---
B3GNT9	84752	broad.mit.edu	37	16	67183811	67183811	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67183811A>T	uc002erf.2	-	2	899	c.578T>A	c.(577-579)CTG>CAG	p.L193Q	uc002erg.1_Missense_Mutation_p.R72W	NM_033309	NP_171608	Q6UX72	B3GN9_HUMAN	UDP-GlcNAc:betaGal	193	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity				0																		---	---	---	---
PLEKHG4	25894	broad.mit.edu	37	16	67320340	67320340	+	Intron	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67320340G>A	uc002eso.3	+						PLEKHG4_uc002esp.3_Intron|PLEKHG4_uc002esq.3_Intron|PLEKHG4_uc010cef.2_Intron|PLEKHG4_uc002ess.3_Intron|PLEKHG4_uc010ceg.2_Intron	NM_015432	NP_056247			pleckstrin homology domain containing, family G						regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)|pancreas(1)	2				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)														---	---	---	---
PLEKHG4	25894	broad.mit.edu	37	16	67322195	67322195	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67322195C>A	uc002eso.3	+	19	5881	c.3346C>A	c.(3346-3348)CTG>ATG	p.L1116M	PLEKHG4_uc002esp.3_Missense_Mutation_p.L923M|PLEKHG4_uc002esq.3_Missense_Mutation_p.L1116M|PLEKHG4_uc010cef.2_Missense_Mutation_p.L1116M|PLEKHG4_uc002ess.3_Missense_Mutation_p.L1116M|PLEKHG4_uc010ceg.2_Missense_Mutation_p.L1035M	NM_015432	NP_056247	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G	1116					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)|pancreas(1)	2				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)														---	---	---	---
TSNAXIP1	55815	broad.mit.edu	37	16	67859956	67859956	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67859956G>A	uc002euj.2	+	9	1353	c.959G>A	c.(958-960)CGG>CAG	p.R320Q	TSNAXIP1_uc010cep.2_3'UTR|TSNAXIP1_uc010vjz.1_Missense_Mutation_p.R197Q|TSNAXIP1_uc002euf.3_Missense_Mutation_p.R28Q|TSNAXIP1_uc010vka.1_Missense_Mutation_p.R374Q|TSNAXIP1_uc010vkb.1_Missense_Mutation_p.R305Q|TSNAXIP1_uc002eug.3_Missense_Mutation_p.R28Q|TSNAXIP1_uc002euh.3_Missense_Mutation_p.R28Q|TSNAXIP1_uc002eui.3_Missense_Mutation_p.R28Q|TSNAXIP1_uc002euk.2_Missense_Mutation_p.R28Q	NM_018430	NP_060900	Q2TAA8	TXIP1_HUMAN	translin-associated factor X interacting protein	320					cell differentiation|multicellular organismal development|spermatogenesis	perinuclear region of cytoplasm					0		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00432)|Epithelial(162;0.0192)|all cancers(182;0.125)														---	---	---	---
EDC4	23644	broad.mit.edu	37	16	67913479	67913479	+	Intron	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67913479T>C	uc002eur.2	+						EDC4_uc010cer.2_Intron|EDC4_uc010vkg.1_Intron|EDC4_uc010ces.1_Intron|EDC4_uc002eus.2_Intron|EDC4_uc002eut.1_5'Flank	NM_014329	NP_055144			autoantigen RCD8						exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|central_nervous_system(2)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)														---	---	---	---
PLA2G15	23659	broad.mit.edu	37	16	68289275	68289275	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:68289275G>A	uc002evr.2	+	4	577	c.494G>A	c.(493-495)CGA>CAA	p.R165Q	PLA2G15_uc010vld.1_Missense_Mutation_p.R165Q|PLA2G15_uc010vle.1_Missense_Mutation_p.E113K|PLA2G15_uc010vlf.1_Intron|PLA2G15_uc002evs.2_5'UTR	NM_012320	NP_036452	Q8NCC3	PAG15_HUMAN	lysophospholipase 3 (lysosomal phospholipase A2)	165					fatty acid catabolic process	extracellular region|lysosome	lysophospholipase activity|phosphatidylcholine-sterol O-acyltransferase activity|phospholipid binding			ovary(1)	1																		---	---	---	---
ZFP90	146198	broad.mit.edu	37	16	68597365	68597365	+	Silent	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:68597365G>T	uc010cff.2	+	5	967	c.675G>T	c.(673-675)TCG>TCT	p.S225S	ZFP90_uc002ewb.2_Missense_Mutation_p.R31L|ZFP90_uc002ewc.2_Missense_Mutation_p.R31L|ZFP90_uc002ewd.2_Silent_p.S225S|ZFP90_uc002ewe.2_Silent_p.S225S	NM_133458	NP_597715	Q8TF47	ZFP90_HUMAN	zinc finger protein 90	225	C2H2-type 1.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00233)|Epithelial(162;0.0184)|all cancers(182;0.0946)														---	---	---	---
CDH3	1001	broad.mit.edu	37	16	68732231	68732231	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:68732231C>T	uc002ewf.2	+	16	3550	c.2418C>T	c.(2416-2418)TAC>TAT	p.Y806Y	CDH3_uc010vli.1_Silent_p.Y751Y	NM_001793	NP_001784	P22223	CADH3_HUMAN	cadherin 3, type 1 preproprotein	806	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|response to stimulus|visual perception	integral to membrane	calcium ion binding	p.?(1)		ovary(3)|breast(1)|skin(1)	5		Ovarian(137;0.0564)		OV - Ovarian serous cystadenocarcinoma(108;0.000782)|Epithelial(162;0.0054)|all cancers(182;0.0384)														---	---	---	---
TMED6	146456	broad.mit.edu	37	16	69377541	69377541	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:69377541G>A	uc002exc.1	-	4	525	c.492C>T	c.(490-492)GAC>GAT	p.D164D		NM_144676	NP_653277	Q8WW62	TMED6_HUMAN	transmembrane emp24 protein transport domain	164	Lumenal (Potential).				transport	endoplasmic reticulum membrane|integral to membrane				ovary(1)	1																		---	---	---	---
DDX19A	55308	broad.mit.edu	37	16	70400155	70400155	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:70400155C>T	uc002eyv.2	+	8	843	c.772C>T	c.(772-774)CGC>TGC	p.R258C	DDX19B_uc010vly.1_Intron|DDX19A_uc002eys.2_Missense_Mutation_p.R259C|DDX19A_uc010cfq.1_Missense_Mutation_p.R13C|DDX19A_uc010cfr.2_Missense_Mutation_p.R108C|DDX19A_uc010cfs.2_Missense_Mutation_p.R81C|DDX19A_uc010vlz.1_Missense_Mutation_p.R227C|DDX19A_uc010vma.1_Missense_Mutation_p.R168C	NM_018332	NP_060802	Q9NUU7	DD19A_HUMAN	DDX19-like protein	258	Helicase ATP-binding.				mRNA transport|protein transport|transmembrane transport	cytoplasm|nuclear membrane|nuclear pore	ATP binding|ATP-dependent helicase activity|RNA binding				0		Ovarian(137;0.221)																---	---	---	---
HYDIN	54768	broad.mit.edu	37	16	70917932	70917932	+	Silent	SNP	G	A	A	rs141625832	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:70917932G>A	uc002ezr.2	-	59	9995	c.9867C>T	c.(9865-9867)GAC>GAT	p.D3289D		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	3290										ovary(1)|skin(1)	2		Ovarian(137;0.0654)																---	---	---	---
HYDIN	54768	broad.mit.edu	37	16	71163613	71163613	+	Missense_Mutation	SNP	G	A	A	rs150136432	byFrequency	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:71163613G>A	uc002ezr.2	-	9	1285	c.1157C>T	c.(1156-1158)GCG>GTG	p.A386V	HYDIN_uc010cfz.1_Missense_Mutation_p.A131V|HYDIN_uc002ezv.2_Missense_Mutation_p.A386V|HYDIN_uc010vmc.1_Missense_Mutation_p.A403V|HYDIN_uc010vmd.1_Missense_Mutation_p.A413V|HYDIN_uc002ezw.3_Missense_Mutation_p.A403V	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	386										ovary(1)|skin(1)	2		Ovarian(137;0.0654)																---	---	---	---
PHLPP2	23035	broad.mit.edu	37	16	71683907	71683907	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:71683907A>C	uc002fax.2	-	18	2864	c.2858T>G	c.(2857-2859)CTG>CGG	p.L953R	PHLPP2_uc002fav.2_Intron|PHLPP2_uc010cgf.2_Missense_Mutation_p.L886R	NM_015020	NP_055835	Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein	953	PP2C-like.					cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
ZFHX3	463	broad.mit.edu	37	16	72993370	72993370	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:72993370G>A	uc002fck.2	-	2	1348	c.675C>T	c.(673-675)AGC>AGT	p.S225S	ZFHX3_uc002fcl.2_Intron	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	225					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)																---	---	---	---
CHST6	4166	broad.mit.edu	37	16	75513508	75513508	+	Silent	SNP	C	T	T	rs140123684		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:75513508C>T	uc002fef.2	-	3	399	c.219G>A	c.(217-219)GCG>GCA	p.A73A	CHST6_uc002feg.1_RNA|CHST6_uc002feh.1_Silent_p.A73A	NM_021615	NP_067628	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	73	Lumenal (Potential).				keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0																		---	---	---	---
ADAMTS18	170692	broad.mit.edu	37	16	77401409	77401409	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:77401409G>T	uc002ffc.3	-	4	1126	c.707C>A	c.(706-708)TCT>TAT	p.S236Y	ADAMTS18_uc002ffe.1_5'UTR|ADAMTS18_uc010vni.1_RNA	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	236					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18																		---	---	---	---
PLCG2	5336	broad.mit.edu	37	16	81944273	81944273	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:81944273G>A	uc002fgt.2	+	18	2034	c.1882G>A	c.(1882-1884)GAG>AAG	p.E628K	PLCG2_uc010chg.1_Missense_Mutation_p.E628K	NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	628	SH2 1.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8																		---	---	---	---
MBTPS1	8720	broad.mit.edu	37	16	84096957	84096957	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:84096957A>G	uc002fhi.2	-	19	3027	c.2525T>C	c.(2524-2526)GTA>GCA	p.V842A	MBTPS1_uc002fhh.2_Missense_Mutation_p.V346A	NM_003791	NP_003782	Q14703	MBTP1_HUMAN	membrane-bound transcription factor site-1	842	Lumenal (Potential).				cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			ovary(2)	2																OREG0023981	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
KCNG4	93107	broad.mit.edu	37	16	84256395	84256395	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:84256395C>A	uc010voc.1	-	3	1109	c.988G>T	c.(988-990)GAG>TAG	p.E330*		NM_172347	NP_758857	Q8TDN1	KCNG4_HUMAN	potassium voltage-gated channel, subfamily G,	330						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)	3																		---	---	---	---
CRISPLD2	83716	broad.mit.edu	37	16	84940242	84940242	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:84940242G>A	uc010voh.1	+	15	1715	c.1488G>A	c.(1486-1488)AGG>AGA	p.R496R	CRISPLD2_uc010vog.1_Intron|CRISPLD2_uc002fio.2_Silent_p.R495R	NM_031476	NP_113664	Q9H0B8	CRLD2_HUMAN	cysteine-rich secretory protein LCCL domain	496						extracellular region|transport vesicle					0																		---	---	---	---
ZCCHC14	23174	broad.mit.edu	37	16	87445308	87445308	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:87445308A>G	uc002fjz.1	-	12	2635	c.2608T>C	c.(2608-2610)TTT>CTT	p.F870L	ZCCHC14_uc002fka.1_RNA|ZCCHC14_uc002fkb.2_Missense_Mutation_p.F646L	NM_015144	NP_055959	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	870					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			upper_aerodigestive_tract(1)|breast(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0285)														---	---	---	---
ZNF778	197320	broad.mit.edu	37	16	89291990	89291990	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:89291990C>T	uc002fmv.2	+	5	611	c.272C>T	c.(271-273)GCA>GTA	p.A91V	ZNF778_uc010vpf.1_RNA|ZNF778_uc002fmw.1_Missense_Mutation_p.A49V|ZNF778_uc010vpg.1_5'UTR	NM_182531	NP_872337	Q96MU6	ZN778_HUMAN	zinc finger protein 778	91	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(80;0.0269)														---	---	---	---
TUBB3	10381	broad.mit.edu	37	16	90002143	90002143	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:90002143C>T	uc002fph.1	+	4	1349	c.1284C>T	c.(1282-1284)GCC>GCT	p.A428A	TUBB3_uc002fpf.2_Silent_p.A775A|TUBB3_uc010ciz.1_Silent_p.A356A|TUBB3_uc002fpg.1_Silent_p.A282A|TUBB3_uc002fpi.1_Silent_p.A356A|TUBB3_uc002fpj.1_Silent_p.A356A|TUBB3_uc010cjb.1_Silent_p.A282A|TUBB3_uc002fpk.1_Silent_p.A282A	NM_006086	NP_006077	Q13509	TBB3_HUMAN	tubulin, beta, 4	428					'de novo' posttranslational protein folding|axon guidance|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(2)|pancreas(1)	3		all_cancers(9;1.69e-11)|Lung NSC(15;8.94e-06)|all_lung(18;1.39e-05)|all_neural(9;0.00581)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0273)														---	---	---	---
ABR	29	broad.mit.edu	37	17	970393	970393	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:970393A>G	uc002fsd.2	-	10	1216	c.1106T>C	c.(1105-1107)GTG>GCG	p.V369A	ABR_uc002fse.2_Missense_Mutation_p.V323A|ABR_uc010vqg.1_Missense_Mutation_p.V151A|ABR_uc002fsg.2_Missense_Mutation_p.V332A|ABR_uc002fsh.1_Missense_Mutation_p.V253A	NM_021962	NP_068781	Q12979	ABR_HUMAN	active breakpoint cluster region-related	369	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0228)														---	---	---	---
PITPNA	5306	broad.mit.edu	37	17	1456410	1456410	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:1456410C>T	uc002fst.3	-	3	341	c.85G>A	c.(85-87)GCC>ACC	p.A29T	PITPNA_uc010cjt.2_5'UTR|PITPNA_uc010cju.2_5'UTR|PITPNA_uc010vqn.1_RNA	NM_006224	NP_006215	Q00169	PIPNA_HUMAN	phosphatidylinositol transfer protein, alpha	29					axon guidance|lipid metabolic process|visual perception	cytoplasm	phosphatidylcholine transmembrane transporter activity|phosphatidylinositol transporter activity|protein binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0845)														---	---	---	---
KIAA0664	23277	broad.mit.edu	37	17	2595920	2595920	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:2595920C>T	uc002fuy.1	-	21	3352	c.3266G>A	c.(3265-3267)CGC>CAC	p.R1089H	KIAA0664_uc002fux.1_Missense_Mutation_p.R1022H|KIAA0664_uc010ckc.1_Missense_Mutation_p.R75H	NM_015229	NP_056044	O75153	K0664_HUMAN	hypothetical protein LOC23277	1089							binding			breast(2)	2																		---	---	---	---
ATP2A3	489	broad.mit.edu	37	17	3846007	3846007	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:3846007G>A	uc002fxb.1	-	12	1589	c.1438C>T	c.(1438-1440)CGG>TGG	p.R480W	ATP2A3_uc002fwx.1_Missense_Mutation_p.R480W|ATP2A3_uc002fwy.1_Missense_Mutation_p.R480W|ATP2A3_uc002fwz.1_Missense_Mutation_p.R480W|ATP2A3_uc002fxa.1_Missense_Mutation_p.R480W|ATP2A3_uc002fxc.1_Missense_Mutation_p.R480W|ATP2A3_uc002fxd.1_Missense_Mutation_p.R480W	NM_174955	NP_777615	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous isoform b	480	Cytoplasmic (By similarity).				ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			ovary(3)|breast(1)|central_nervous_system(1)	5				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)														---	---	---	---
ANKFY1	51479	broad.mit.edu	37	17	4086805	4086805	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:4086805C>T	uc002fxq.1	-	14	1878	c.1840G>A	c.(1840-1842)GCC>ACC	p.A614T	ANKFY1_uc002fxn.2_Missense_Mutation_p.A656T|ANKFY1_uc002fxo.2_Missense_Mutation_p.A614T|ANKFY1_uc002fxp.2_Missense_Mutation_p.A613T|ANKFY1_uc010ckp.2_Missense_Mutation_p.A555T	NM_016376	NP_057460	Q9P2R3	ANFY1_HUMAN	ankyrin repeat and FYVE domain containing 1	614	ANK 8.					endosome membrane	metal ion binding|protein binding			ovary(2)|skin(1)	3																		---	---	---	---
MYBBP1A	10514	broad.mit.edu	37	17	4451551	4451551	+	Silent	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:4451551A>G	uc002fyb.3	-	12	1673	c.1611T>C	c.(1609-1611)GGT>GGC	p.G537G	MYBBP1A_uc002fxz.3_Silent_p.G537G	NM_014520	NP_055335	Q9BQG0	MBB1A_HUMAN	MYB binding protein 1a isoform 2	537	Interaction with MYB (By similarity).				nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			ovary(1)|skin(1)	2																		---	---	---	---
PLD2	5338	broad.mit.edu	37	17	4722789	4722789	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:4722789G>A	uc002fzc.2	+	23	2475	c.2374G>A	c.(2374-2376)GAG>AAG	p.E792K	PLD2_uc002fzd.2_Missense_Mutation_p.E792K	NM_002663	NP_002654	O14939	PLD2_HUMAN	phospholipase D2	792					cell communication|cytoskeleton organization|small GTPase mediated signal transduction		NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	5					Choline(DB00122)													---	---	---	---
ENO3	2027	broad.mit.edu	37	17	4856581	4856581	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:4856581G>A	uc002gab.3	+	5	349	c.255G>A	c.(253-255)GCG>GCA	p.A85A	ENO3_uc010vsr.1_5'UTR|ENO3_uc002gac.3_Silent_p.A85A|ENO3_uc010vss.1_Intron|ENO3_uc010vst.1_5'Flank	NM_053013	NP_443739	P13929	ENOB_HUMAN	enolase 3	85					gluconeogenesis|glycolysis	phosphopyruvate hydratase complex	magnesium ion binding|phosphopyruvate hydratase activity			ovary(1)	1																		---	---	---	---
CAMTA2	23125	broad.mit.edu	37	17	4876497	4876497	+	Silent	SNP	G	A	A	rs137951157	byFrequency	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:4876497G>A	uc002gah.1	-	14	2361	c.2253C>T	c.(2251-2253)AAC>AAT	p.N751N	CAMTA2_uc010cku.1_Silent_p.N774N|CAMTA2_uc002gag.1_Silent_p.N750N|CAMTA2_uc002gai.1_Silent_p.N753N|CAMTA2_uc010ckv.1_Silent_p.N398N	NM_015099	NP_055914	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	751					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			ovary(1)	1																		---	---	---	---
CAMTA2	23125	broad.mit.edu	37	17	4876881	4876881	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:4876881G>A	uc002gah.1	-	13	2308	c.2200C>T	c.(2200-2202)CGG>TGG	p.R734W	CAMTA2_uc010cku.1_Missense_Mutation_p.R757W|CAMTA2_uc002gag.1_Missense_Mutation_p.R733W|CAMTA2_uc002gai.1_Missense_Mutation_p.R736W|CAMTA2_uc010ckv.1_Missense_Mutation_p.R381W	NM_015099	NP_055914	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	734	ANK 1.				cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			ovary(1)	1																		---	---	---	---
KIF1C	10749	broad.mit.edu	37	17	4906103	4906103	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:4906103G>T	uc002gan.1	+	8	1012	c.686G>T	c.(685-687)TGC>TTC	p.C229F		NM_006612	NP_006603	O43896	KIF1C_HUMAN	kinesin family member 1C	229	Kinesin-motor.				microtubule-based movement|retrograde vesicle-mediated transport, Golgi to ER	endoplasmic reticulum|Golgi apparatus|microtubule	ATP binding|microtubule motor activity			breast(2)	2																		---	---	---	---
PITPNM3	83394	broad.mit.edu	37	17	6374548	6374548	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:6374548G>A	uc002gdd.3	-	12	1708	c.1557C>T	c.(1555-1557)AGC>AGT	p.S519S	PITPNM3_uc010cln.2_Silent_p.S483S|PITPNM3_uc010clm.2_Silent_p.S2S|PITPNM3_uc002gdc.3_Silent_p.S110S	NM_031220	NP_112497	Q9BZ71	PITM3_HUMAN	PITPNM family member 3 isoform 1	519	DDHD.				phosphatidylinositol metabolic process	endomembrane system|integral to membrane	calcium ion binding|lipid binding|phosphatidylinositol transporter activity|receptor tyrosine kinase binding			ovary(2)|central_nervous_system(2)	4				Colorectal(2;0.000372)|READ - Rectum adenocarcinoma(2;0.0276)|LUAD - Lung adenocarcinoma(2;0.0836)|COAD - Colon adenocarcinoma(228;0.185)														---	---	---	---
NEURL4	84461	broad.mit.edu	37	17	7221432	7221432	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7221432C>T	uc002gga.1	-	25	4019	c.4012G>A	c.(4012-4014)GAG>AAG	p.E1338K	GPS2_uc002gfv.1_5'Flank|GPS2_uc002gfw.1_5'Flank|GPS2_uc002gfx.1_5'Flank|NEURL4_uc002gfy.1_RNA|GPS2_uc002gfz.1_5'UTR|NEURL4_uc002ggb.1_Missense_Mutation_p.E1336K	NM_032442	NP_115818	Q96JN8	NEUL4_HUMAN	neuralized homolog 4 isoform 1	1338							protein binding			upper_aerodigestive_tract(1)|ovary(1)	2																		---	---	---	---
ACAP1	9744	broad.mit.edu	37	17	7247079	7247079	+	Intron	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7247079G>T	uc002ggd.2	+							NM_014716	NP_055531			centaurin beta1						intracellular signal transduction|lipid metabolic process|protein transport|regulation of ARF GTPase activity		ARF GTPase activator activity|phospholipase C activity|protein binding|zinc ion binding			breast(2)|large_intestine(1)	3																		---	---	---	---
TP53	7157	broad.mit.edu	37	17	7577022	7577022	+	Nonsense_Mutation	SNP	G	A	A	rs121913344		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7577022G>A	uc002gim.2	-	8	1110	c.916C>T	c.(916-918)CGA>TGA	p.R306*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Nonsense_Mutation_p.R306*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.R174*|TP53_uc010cng.1_Nonsense_Mutation_p.R174*|TP53_uc002gii.1_Nonsense_Mutation_p.R174*|TP53_uc010cnh.1_Nonsense_Mutation_p.R306*|TP53_uc010cni.1_Nonsense_Mutation_p.R306*|TP53_uc002gij.2_Nonsense_Mutation_p.R306*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	306	Bipartite nuclear localization signal.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.		R -> Q (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R306*(99)|p.0?(7)|p.?(3)|p.R306R(2)|p.R306fs*39(2)|p.K305fs*1(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		R306*(MFE296_ENDOMETRIUM)|R306*(HCC1937_BREAST)|R306*(MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R306*(RCM1_LARGE_INTESTINE)|R306*(JURLMK1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---	---
DNAH2	146754	broad.mit.edu	37	17	7671512	7671512	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7671512C>T	uc002giu.1	+	23	3882	c.3868C>T	c.(3868-3870)CGC>TGC	p.R1290C		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	1290	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)																---	---	---	---
MYH13	8735	broad.mit.edu	37	17	10214487	10214487	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:10214487G>A	uc002gmk.1	-	33	4679	c.4589C>T	c.(4588-4590)GCG>GTG	p.A1530V		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1530	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6																		---	---	---	---
MYH8	4626	broad.mit.edu	37	17	10309612	10309612	+	Silent	SNP	T	C	C	rs145901155	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:10309612T>C	uc002gmm.2	-	20	2369	c.2274A>G	c.(2272-2274)CAA>CAG	p.Q758Q	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	758	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11														Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				---	---	---	---
MYH2	4620	broad.mit.edu	37	17	10427956	10427956	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:10427956G>A	uc010coi.2	-	35	5130	c.5002C>T	c.(5002-5004)CGG>TGG	p.R1668W	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.R1668W|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1668	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14																		---	---	---	---
MYH3	4621	broad.mit.edu	37	17	10535238	10535238	+	Silent	SNP	G	A	A	rs149260479		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:10535238G>A	uc002gmq.1	-	34	5129	c.5052C>T	c.(5050-5052)GCC>GCT	p.A1684A		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	1684	Potential.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7																		---	---	---	---
SCO1	6341	broad.mit.edu	37	17	10600694	10600694	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:10600694A>T	uc002gmr.3	-	1	192	c.131T>A	c.(130-132)TTC>TAC	p.F44Y	SCO1_uc002gms.3_Missense_Mutation_p.F44Y|C17orf48_uc002gmt.2_5'Flank|C17orf48_uc002gmu.2_5'Flank|C17orf48_uc002gmv.2_5'Flank	NM_004589	NP_004580	O75880	SCO1_HUMAN	cytochrome oxidase deficient homolog 1	44					cellular copper ion homeostasis|copper ion transport|generation of precursor metabolites and energy|respiratory chain complex IV assembly	mitochondrial inner membrane	copper ion binding				0																		---	---	---	---
CDRT4	284040	broad.mit.edu	37	17	15341260	15341260	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:15341260A>T	uc002gop.1	-	4	567	c.286T>A	c.(286-288)TCC>ACC	p.S96T	CDRT4_uc010vvw.1_3'UTR	NM_173622	NP_775893	Q8N9R6	CDRT4_HUMAN	CMT1A duplicated region transcript 4	96											0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0874)														---	---	---	---
PIGL	9487	broad.mit.edu	37	17	16221154	16221154	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:16221154C>T	uc002gpv.2	+	6	624	c.592C>T	c.(592-594)CCC>TCC	p.P198S		NM_004278	NP_004269	Q9Y2B2	PIGL_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	198	Cytoplasmic (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	N-acetylglucosaminylphosphatidylinositol deacetylase activity				0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0934)														---	---	---	---
MPRIP	23164	broad.mit.edu	37	17	17062044	17062044	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:17062044C>T	uc002gqu.1	+	14	1830	c.1774C>T	c.(1774-1776)CGC>TGC	p.R592C	MPRIP_uc002gqv.1_Missense_Mutation_p.R592C|MPRIP_uc002gqw.1_Missense_Mutation_p.R347C	NM_201274	NP_958431	Q6WCQ1	MPRIP_HUMAN	myosin phosphatase-Rho interacting protein	592	Interaction with RHOA.					cytoplasm|cytoskeleton	actin binding				0																		---	---	---	---
TOM1L2	146691	broad.mit.edu	37	17	17772673	17772673	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:17772673C>T	uc002grz.3	-	8	1049	c.892G>A	c.(892-894)GTC>ATC	p.V298I	TOM1L2_uc002gry.3_Missense_Mutation_p.V248I|TOM1L2_uc010vwy.1_Missense_Mutation_p.V245I|TOM1L2_uc010cpr.2_Missense_Mutation_p.V253I|TOM1L2_uc010vwz.1_Missense_Mutation_p.V150I|TOM1L2_uc010vxa.1_Missense_Mutation_p.V200I|TOM1L2_uc010vxb.1_Missense_Mutation_p.V248I|TOM1L2_uc002grv.3_Missense_Mutation_p.V31I	NM_001082968	NP_001076437	Q6ZVM7	TM1L2_HUMAN	target of myb1-like 2 isoform 3	298	GAT.				intracellular protein transport	intracellular					0	all_neural(463;0.228)																	---	---	---	---
LRRC48	83450	broad.mit.edu	37	17	17900948	17900948	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:17900948G>A	uc010vxd.1	+	10	1378	c.999G>A	c.(997-999)TCG>TCA	p.S333S	LRRC48_uc002gsa.2_Silent_p.S333S|LRRC48_uc010vxc.1_Silent_p.S333S|LRRC48_uc002gsb.2_Silent_p.S333S|LRRC48_uc010vxe.1_RNA	NM_001130090	NP_001123562	Q9H069	LRC48_HUMAN	leucine rich repeat containing 48 isoform a	333						cytoplasm				pancreas(1)	1	all_neural(463;0.228)																	---	---	---	---
MYO15A	51168	broad.mit.edu	37	17	18023744	18023744	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:18023744C>T	uc010vxh.1	+	2	1968	c.1630C>T	c.(1630-1632)CGC>TGC	p.R544C		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	544	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)																	---	---	---	---
TRIM16L	147166	broad.mit.edu	37	17	18631034	18631034	+	Missense_Mutation	SNP	C	T	T	rs141461321	byFrequency	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:18631034C>T	uc002gug.1	+	7	851	c.164C>T	c.(163-165)ACG>ATG	p.T55M	TRIM16L_uc010vyf.1_Missense_Mutation_p.T109M|TRIM16L_uc002guh.1_Missense_Mutation_p.T55M|TRIM16L_uc010cqg.1_Missense_Mutation_p.T157M|TRIM16L_uc002gui.1_Missense_Mutation_p.T55M|TRIM16L_uc010vyg.1_Missense_Mutation_p.T55M|TRIM16L_uc010vyh.1_Missense_Mutation_p.T55M	NM_001037330	NP_001032407	Q309B1	TR16L_HUMAN	tripartite motif-containing 16-like	55						cytoplasm					0																		---	---	---	---
AKAP10	11216	broad.mit.edu	37	17	19827816	19827816	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:19827816T>C	uc002gwo.2	-	11	1793	c.1656A>G	c.(1654-1656)AAA>AAG	p.K552K	AKAP10_uc002gwp.1_Silent_p.K552K|AKAP10_uc010cqw.1_Silent_p.K494K	NM_007202	NP_009133	O43572	AKA10_HUMAN	A-kinase anchor protein 10 precursor	552					blood coagulation|protein localization	cytosol|mitochondrion|plasma membrane	signal transducer activity			skin(1)	1	all_cancers(12;2.08e-05)|all_epithelial(12;0.00158)|Breast(13;0.165)																	---	---	---	---
SLC13A2	9058	broad.mit.edu	37	17	26817568	26817568	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:26817568G>A	uc002hbh.2	+	3	395	c.328G>A	c.(328-330)GCC>ACC	p.A110T	SLC13A2_uc010wal.1_Missense_Mutation_p.A67T|SLC13A2_uc010wam.1_Missense_Mutation_p.A66T|SLC13A2_uc010wan.1_Missense_Mutation_p.A159T|SLC13A2_uc010wao.1_Missense_Mutation_p.A67T|SLC13A2_uc002hbi.2_Missense_Mutation_p.A39T	NM_003984	NP_003975	Q13183	S13A2_HUMAN	solute carrier family 13, member 2 isoform b	110						integral to plasma membrane|membrane fraction	low affinity sodium:dicarboxylate symporter activity				0	all_lung(13;0.000871)|Lung NSC(42;0.0027)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)	Succinic acid(DB00139)													---	---	---	---
KIAA0100	9703	broad.mit.edu	37	17	26942696	26942696	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:26942696C>T	uc002hbu.2	-	38	6610	c.6511G>A	c.(6511-6513)GCC>ACC	p.A2171T	SGK494_uc010waq.1_5'Flank|SGK494_uc010war.1_5'Flank|SGK494_uc002hbr.1_5'Flank|uc002hbs.1_Intron|KIAA0100_uc002hbt.2_Missense_Mutation_p.A500T	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	2171						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)																	---	---	---	---
CDK5R1	8851	broad.mit.edu	37	17	30814938	30814938	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:30814938G>A	uc002hhn.2	+	2	521	c.300G>A	c.(298-300)CAG>CAA	p.Q100Q	CDK5R1_uc010wca.1_Silent_p.Q100Q|CDK5R1_uc010ctc.2_5'UTR	NM_003885	NP_003876	Q15078	CD5R1_HUMAN	cyclin-dependent kinase 5, regulatory subunit 1	100					axon guidance|axonal fasciculation|brain development|cell proliferation|embryo development|ionotropic glutamate receptor signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of transcription, DNA-dependent|neuron cell-cell adhesion|neuron migration|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of neuron apoptosis|regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation	axon|contractile fiber|cyclin-dependent protein kinase 5 holoenzyme complex|cytosol|dendritic spine|growth cone|neuromuscular junction|neuronal cell body|perinuclear region of cytoplasm|plasma membrane	cadherin binding|calcium ion binding|protein kinase binding			ovary(1)	1		Breast(31;0.159)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.0938)															---	---	---	---
CCL11	6356	broad.mit.edu	37	17	32614701	32614701	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:32614701A>G	uc002hia.1	+	3	427	c.286A>G	c.(286-288)AAG>GAG	p.K96E		NM_002986	NP_002977	P51671	CCL11_HUMAN	small inducible cytokine A11 precursor	96					cell adhesion|cellular calcium ion homeostasis|immune response|positive regulation of actin filament polymerization|positive regulation of cell migration|positive regulation of endothelial cell proliferation|positive regulation of Rac GTPase activity|protein phosphorylation|response to radiation|response to virus|signal transduction	extracellular space	chemokine activity				0	Breast(3;0.00224)	Breast(31;0.151)|Ovarian(249;0.17)		BRCA - Breast invasive adenocarcinoma(366;0.155)														---	---	---	---
SLFN11	91607	broad.mit.edu	37	17	33690471	33690471	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:33690471C>T	uc010ctp.2	-	4	798	c.356G>A	c.(355-357)CGC>CAC	p.R119H	SLFN11_uc010ctq.2_Missense_Mutation_p.R119H|SLFN11_uc002hjh.3_Missense_Mutation_p.R119H|SLFN11_uc002hjg.3_Missense_Mutation_p.R119H|SLFN11_uc010ctr.2_Missense_Mutation_p.R119H	NM_001104588	NP_001098058	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	119						nucleus	ATP binding			large_intestine(1)|ovary(1)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)														---	---	---	---
MYO19	80179	broad.mit.edu	37	17	34856778	34856778	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:34856778G>A	uc010wcy.1	-	24	3261	c.2269C>T	c.(2269-2271)CGT>TGT	p.R757C	MYO19_uc002hmw.2_Missense_Mutation_p.R557C|MYO19_uc010cuu.2_RNA	NM_001163735	NP_001157207	Q96H55	MYO19_HUMAN	myosin XIX isoform 2	757						mitochondrial outer membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)	1		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)														---	---	---	---
GGNBP2	79893	broad.mit.edu	37	17	34943636	34943636	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:34943636C>T	uc002hnb.2	+	13	2100	c.1851C>T	c.(1849-1851)CCC>CCT	p.P617P		NM_024835	NP_079111	Q9H3C7	GGNB2_HUMAN	zinc finger protein 403	617					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasmic membrane-bounded vesicle				ovary(2)	2		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)														---	---	---	---
ACACA	31	broad.mit.edu	37	17	35445936	35445936	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:35445936T>C	uc002hnm.2	-	55	7045	c.6854A>G	c.(6853-6855)CAC>CGC	p.H2285R	ACACA_uc002hnk.2_Missense_Mutation_p.H2207R|ACACA_uc002hnl.2_Missense_Mutation_p.H2227R|ACACA_uc002hnn.2_Missense_Mutation_p.H2285R|ACACA_uc002hno.2_Missense_Mutation_p.H2322R|ACACA_uc010cuy.2_Missense_Mutation_p.H930R|ACACA_uc010wdb.1_Missense_Mutation_p.H323R|ACACA_uc010wdc.1_Missense_Mutation_p.H411R	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	2285					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)													---	---	---	---
ACACA	31	broad.mit.edu	37	17	35583264	35583264	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:35583264C>T	uc002hnm.2	-	26	3436	c.3245G>A	c.(3244-3246)CGC>CAC	p.R1082H	ACACA_uc002hnk.2_Missense_Mutation_p.R1004H|ACACA_uc002hnl.2_Missense_Mutation_p.R1024H|ACACA_uc002hnn.2_Missense_Mutation_p.R1082H|ACACA_uc002hno.2_Missense_Mutation_p.R1119H|ACACA_uc010cuz.2_Missense_Mutation_p.R1082H	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	1082					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)													---	---	---	---
ACACA	31	broad.mit.edu	37	17	35591892	35591892	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:35591892T>C	uc002hnm.2	-	25	3324	c.3133A>G	c.(3133-3135)ATT>GTT	p.I1045V	ACACA_uc002hnk.2_Missense_Mutation_p.I967V|ACACA_uc002hnl.2_Missense_Mutation_p.I987V|ACACA_uc002hnn.2_Missense_Mutation_p.I1045V|ACACA_uc002hno.2_Missense_Mutation_p.I1082V|ACACA_uc010cuz.2_Missense_Mutation_p.I1045V	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	1045					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)													---	---	---	---
GPR179	440435	broad.mit.edu	37	17	36482648	36482648	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:36482648G>A	uc002hpz.2	-	11	6825	c.6804C>T	c.(6802-6804)CCC>CCT	p.P2268P		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	2268	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)																---	---	---	---
PSMB3	5691	broad.mit.edu	37	17	36912143	36912143	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:36912143C>T	uc002hqr.2	+	3	274	c.196C>T	c.(196-198)CGC>TGC	p.R66C		NM_002795	NP_002786	P49720	PSB3_HUMAN	proteasome beta 3 subunit	66					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	protein binding|threonine-type endopeptidase activity				0																		---	---	---	---
SMARCE1	6605	broad.mit.edu	37	17	38792665	38792665	+	Silent	SNP	G	A	A	rs149613910	byFrequency	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:38792665G>A	uc002hux.2	-	6	475	c.351C>T	c.(349-351)AAC>AAT	p.N117N	SMARCE1_uc010wff.1_Silent_p.N82N|SMARCE1_uc010wfg.1_Silent_p.N47N|SMARCE1_uc002huy.2_Silent_p.N82N|SMARCE1_uc010wfh.1_Silent_p.N47N|SMARCE1_uc010wfi.1_Silent_p.N99N|SMARCE1_uc002huz.1_Silent_p.N82N|SMARCE1_uc010wfj.1_Silent_p.N99N	NM_003079	NP_003070	Q969G3	SMCE1_HUMAN	SWI/SNF-related matrix-associated	117	HMG box.				chromatin modification|negative regulation of transcription, DNA-dependent|nervous system development|nucleosome disassembly|regulation of transcription from RNA polymerase II promoter	nBAF complex|npBAF complex|nuclear chromosome|SWI/SNF complex|transcriptional repressor complex	chromatin binding|DNA binding|N-acetyltransferase activity|protein binding|protein N-terminus binding|transcription coactivator activity				0		Breast(137;0.000812)																---	---	---	---
KRT27	342574	broad.mit.edu	37	17	38936701	38936701	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:38936701T>C	uc002hvg.2	-	3	576	c.535A>G	c.(535-537)AAC>GAC	p.N179D		NM_181537	NP_853515	Q7Z3Y8	K1C27_HUMAN	keratin 27	179	Rod.|Coil 1B.					cytoplasm|intermediate filament	structural molecule activity				0		Breast(137;0.000812)																---	---	---	---
KRT12	3859	broad.mit.edu	37	17	39020028	39020028	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:39020028T>A	uc002hvk.2	-	4	920	c.896A>T	c.(895-897)AAT>ATT	p.N299I		NM_000223	NP_000214	Q99456	K1C12_HUMAN	keratin 12	299	Rod.|Coil 2.				visual perception	intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)																---	---	---	---
KRTAP4-12	83755	broad.mit.edu	37	17	39279857	39279857	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:39279857C>T	uc002hwa.2	-	1	563	c.518G>A	c.(517-519)CGA>CAA	p.R173Q		NM_031854	NP_114060	Q9BQ66	KR412_HUMAN	keratin associated protein 4-12	173						keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)															---	---	---	---
CNTNAP1	8506	broad.mit.edu	37	17	40843980	40843980	+	Missense_Mutation	SNP	G	A	A	rs142029931	byFrequency	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40843980G>A	uc002iay.2	+	16	2717	c.2501G>A	c.(2500-2502)CGC>CAC	p.R834H	CNTNAP1_uc010wgs.1_RNA	NM_003632	NP_003623	P78357	CNTP1_HUMAN	contactin associated protein 1 precursor	834	Laminin G-like 3.|Extracellular (Potential).				axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(3)|breast(3)|upper_aerodigestive_tract(1)|lung(1)	8		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)														---	---	---	---
WNK4	65266	broad.mit.edu	37	17	40936583	40936583	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40936583C>T	uc002ibj.2	+	4	1177	c.1156C>T	c.(1156-1158)CGC>TGC	p.R386C	WNK4_uc010wgx.1_Silent_p.T79T|WNK4_uc002ibk.1_Missense_Mutation_p.R158C|WNK4_uc010wgy.1_5'Flank	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	386	Protein kinase.				intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)														---	---	---	---
G6PC	2538	broad.mit.edu	37	17	41063035	41063035	+	Silent	SNP	A	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:41063035A>T	uc002icb.1	+	5	745	c.666A>T	c.(664-666)GGA>GGT	p.G222G	G6PC_uc010whf.1_3'UTR	NM_000151	NP_000142	P35575	G6PC_HUMAN	glucose-6-phosphatase, catalytic subunit	222	Helical; (Potential).		G -> R (in GSD1A).		gluconeogenesis|glucose homeostasis|transmembrane transport	integral to endoplasmic reticulum membrane	glucose-6-phosphatase activity|phosphate binding			ovary(1)|breast(1)|kidney(1)|skin(1)	4		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.113)										Glycogen_Storage_Disease_type_Ia				---	---	---	---
FZD2	2535	broad.mit.edu	37	17	42636437	42636437	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:42636437C>T	uc002igx.1	+	1	1513	c.1381C>T	c.(1381-1383)CGC>TGC	p.R461C		NM_001466	NP_001457	Q14332	FZD2_HUMAN	frizzled 2 precursor	461	Cytoplasmic (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|positive regulation of cGMP metabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)														---	---	---	---
PLEKHM1	9842	broad.mit.edu	37	17	43545801	43545801	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:43545801G>A	uc002ija.2	-	5	1252	c.1082C>T	c.(1081-1083)GCC>GTC	p.A361V	PLEKHM1_uc010wjm.1_Missense_Mutation_p.A333V|PLEKHM1_uc002ijb.2_Intron|PLEKHM1_uc010wjn.1_Missense_Mutation_p.A310V	NM_014798	NP_055613	Q9Y4G2	PKHM1_HUMAN	pleckstrin homology domain containing, family M	361					intracellular signal transduction	cytoplasm	metal ion binding				0	Renal(3;0.0405)																	---	---	---	---
NSF	4905	broad.mit.edu	37	17	44770370	44770370	+	Silent	SNP	T	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:44770370T>G	uc002iku.2	+	10	1151	c.1047T>G	c.(1045-1047)ACT>ACG	p.T349T	NSF_uc010wke.1_Silent_p.T255T|NSF_uc010wkf.1_Silent_p.T255T|NSF_uc010wkg.1_Silent_p.T344T	NM_006178	NP_006169	P46459	NSF_HUMAN	vesicle-fusing ATPase	349					protein transport|synaptic transmission	cytosol	ATP binding|metal ion binding			ovary(1)	1		Melanoma(429;0.203)	BRCA - Breast invasive adenocarcinoma(9;0.0257)	BRCA - Breast invasive adenocarcinoma(366;0.241)														---	---	---	---
MYL4	4635	broad.mit.edu	37	17	45299152	45299152	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:45299152C>T	uc002ilg.2	+	5	546	c.418C>T	c.(418-420)CGT>TGT	p.R140C	MYL4_uc002ilh.2_Missense_Mutation_p.R140C	NM_001002841	NP_001002841	P12829	MYL4_HUMAN	atrial/embryonic alkali myosin light chain	140	EF-hand 2.				cardiac muscle contraction|muscle filament sliding|muscle organ development|positive regulation of ATPase activity|regulation of the force of heart contraction	A band|cytosol|muscle myosin complex	actin filament binding|actin monomer binding|calcium ion binding|myosin II heavy chain binding|structural constituent of muscle			ovary(2)	2																		---	---	---	---
KPNB1	3837	broad.mit.edu	37	17	45748109	45748109	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:45748109C>T	uc002ilt.1	+	12	1794	c.1458C>T	c.(1456-1458)GAC>GAT	p.D486D	KPNB1_uc010wkw.1_Silent_p.D341D|KPNB1_uc010wkx.1_Silent_p.D270D	NM_002265	NP_002256	Q14974	IMB1_HUMAN	karyopherin beta 1	486					DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|protein import into nucleus, translocation|ribosomal protein import into nucleus|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein domain specific binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3																		---	---	---	---
TBKBP1	9755	broad.mit.edu	37	17	45773476	45773476	+	5'UTR	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:45773476A>G	uc002ilu.2	+	1						NM_014726	NP_055541			TBK1 binding protein 1						innate immune response						0																		---	---	---	---
RSAD1	55316	broad.mit.edu	37	17	48559584	48559584	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:48559584C>T	uc002iqw.1	+	4	663	c.607C>T	c.(607-609)CAG>TAG	p.Q203*	RSAD1_uc010wmq.1_RNA	NM_018346	NP_060816	Q9HA92	RSAD1_HUMAN	radical S-adenosyl methionine domain containing	203					porphyrin biosynthetic process	mitochondrion	4 iron, 4 sulfur cluster binding|coproporphyrinogen oxidase activity|metal ion binding				0	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)													OREG0024567	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
MKS1	54903	broad.mit.edu	37	17	56291179	56291179	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:56291179G>A	uc002ivr.1	-	7	771	c.696C>T	c.(694-696)AGC>AGT	p.S232S	MKS1_uc010wnq.1_Silent_p.S29S|MKS1_uc002ivs.1_Silent_p.S232S	NM_017777	NP_060247	Q9NXB0	MKS1_HUMAN	Meckel syndrome type 1 protein isoform 1	232					cilium assembly	centrosome|cilium|microtubule basal body	protein binding			ovary(1)	1																		---	---	---	---
HSF5	124535	broad.mit.edu	37	17	56536295	56536295	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:56536295G>T	uc002iwi.1	-	5	1678	c.1554C>A	c.(1552-1554)AAC>AAA	p.N518K		NM_001080439	NP_001073908	Q4G112	HSF5_HUMAN	heat shock transcription factor family member 5	518						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)																	---	---	---	---
TEX14	56155	broad.mit.edu	37	17	56707884	56707884	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:56707884G>A	uc010dcz.1	-	3	286	c.168C>T	c.(166-168)GGC>GGT	p.G56G	TEX14_uc002iwr.1_Silent_p.G56G|TEX14_uc002iws.1_Silent_p.G56G|TEX14_uc010dda.1_5'UTR	NM_198393	NP_938207	Q8IWB6	TEX14_HUMAN	testis expressed sequence 14 isoform a	56	ANK 2.					cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)																	---	---	---	---
PPM1E	22843	broad.mit.edu	37	17	57050270	57050270	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:57050270G>A	uc002iwx.2	+	6	1321	c.1194G>A	c.(1192-1194)TCG>TCA	p.S398S	PPM1E_uc010ddd.2_Silent_p.S161S	NM_014906	NP_055721	Q8WY54	PPM1E_HUMAN	protein phosphatase 1E	407	PP2C-like.				protein dephosphorylation	cytoplasm|nucleolus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			breast(3)|lung(1)|skin(1)	5	Medulloblastoma(34;0.127)|all_neural(34;0.237)		BRCA - Breast invasive adenocarcinoma(1;5.76e-11)															---	---	---	---
BCAS3	54828	broad.mit.edu	37	17	58988001	58988001	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:58988001C>T	uc002iyv.3	+	12	1040	c.931C>T	c.(931-933)CGG>TGG	p.R311W	BCAS3_uc010wow.1_Missense_Mutation_p.R98W|BCAS3_uc002iyu.3_Missense_Mutation_p.R311W|BCAS3_uc002iyw.3_Missense_Mutation_p.R307W|BCAS3_uc002iyx.1_Missense_Mutation_p.R126W|BCAS3_uc002iyy.3_Missense_Mutation_p.R82W	NM_001099432	NP_001092902	Q9H6U6	BCAS3_HUMAN	breast carcinoma amplified sequence 3 isoform 1	311						nucleus				ovary(2)|central_nervous_system(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)															---	---	---	---
TLK2	11011	broad.mit.edu	37	17	60558534	60558534	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:60558534G>A	uc010ddp.2	+	2	316	c.48G>A	c.(46-48)TTG>TTA	p.L16L	TLK2_uc002izx.3_5'UTR|TLK2_uc002izz.3_Silent_p.L16L|TLK2_uc002jaa.3_Silent_p.L16L|TLK2_uc010wpd.1_Silent_p.L16L	NM_006852	NP_006843	Q86UE8	TLK2_HUMAN	tousled-like kinase 2 isoform A	16					cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|kidney(1)	2																		---	---	---	---
TLK2	11011	broad.mit.edu	37	17	60637490	60637490	+	Intron	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:60637490T>C	uc010ddp.2	+						TLK2_uc002izx.3_Intron|TLK2_uc002izz.3_Intron|TLK2_uc002jaa.3_Intron|TLK2_uc010wpd.1_Intron	NM_006852	NP_006843			tousled-like kinase 2 isoform A						cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|kidney(1)	2																		---	---	---	---
TLK2	11011	broad.mit.edu	37	17	60679539	60679539	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:60679539T>C	uc010ddp.2	+	20	2191	c.1923T>C	c.(1921-1923)TAT>TAC	p.Y641Y	TLK2_uc002izx.3_Silent_p.Y467Y|TLK2_uc002izz.3_Silent_p.Y619Y|TLK2_uc002jaa.3_Silent_p.Y587Y|TLK2_uc010wpd.1_Silent_p.Y587Y	NM_006852	NP_006843	Q86UE8	TLK2_HUMAN	tousled-like kinase 2 isoform A	641	Protein kinase.				cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|kidney(1)	2																		---	---	---	---
ACE	1636	broad.mit.edu	37	17	61557223	61557223	+	Missense_Mutation	SNP	C	T	T	rs148460287	byFrequency	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:61557223C>T	uc002jau.1	+	4	627	c.605C>T	c.(604-606)CCG>CTG	p.P202L	ACE_uc010wpi.1_Missense_Mutation_p.P202L|ACE_uc010ddu.1_Missense_Mutation_p.P19L	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	202	Extracellular (Potential).|Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)													---	---	---	---
KCNH6	81033	broad.mit.edu	37	17	61619795	61619795	+	Silent	SNP	C	T	T	rs75754003		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:61619795C>T	uc002jay.2	+	9	2228	c.2148C>T	c.(2146-2148)GAC>GAT	p.D716D	KCNH6_uc010wpl.1_Silent_p.D593D|KCNH6_uc010wpm.1_Silent_p.D716D|KCNH6_uc002jaz.1_Silent_p.D663D	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	716	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)													---	---	---	---
KCNH6	81033	broad.mit.edu	37	17	61620997	61620997	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:61620997T>C	uc002jay.2	+	10	2289	c.2209T>C	c.(2209-2211)TTC>CTC	p.F737L	KCNH6_uc010wpl.1_Missense_Mutation_p.F614L|KCNH6_uc010wpm.1_Missense_Mutation_p.F737L|KCNH6_uc002jaz.1_Missense_Mutation_p.F684L	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	737	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)													---	---	---	---
SCN4A	6329	broad.mit.edu	37	17	62025282	62025282	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:62025282C>T	uc002jds.1	-	17	3363	c.3286G>A	c.(3286-3288)GCC>ACC	p.A1096T		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	1096	III.|Helical; Name=S3 of repeat III; (Potential).				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)													---	---	---	---
SCN4A	6329	broad.mit.edu	37	17	62049998	62049998	+	Silent	SNP	G	A	A	rs80266947	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:62049998G>A	uc002jds.1	-	1	281	c.204C>T	c.(202-204)TAC>TAT	p.Y68Y		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	68					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)													---	---	---	---
TEX2	55852	broad.mit.edu	37	17	62291193	62291193	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:62291193T>C	uc002jec.2	-	2	558	c.385A>G	c.(385-387)ACA>GCA	p.T129A	TEX2_uc002jed.2_Missense_Mutation_p.T129A|TEX2_uc002jee.2_Missense_Mutation_p.T129A	NM_018469	NP_060939	Q8IWB9	TEX2_HUMAN	testis expressed sequence 2	129					signal transduction|sphingolipid metabolic process	integral to membrane				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)														---	---	---	---
AXIN2	8313	broad.mit.edu	37	17	63554010	63554010	+	Silent	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:63554010A>G	uc002jfi.2	-	2	1018	c.729T>C	c.(727-729)CTT>CTC	p.L243L	AXIN2_uc010den.1_Silent_p.L243L|AXIN2_uc002jfh.2_Silent_p.L243L|AXIN2_uc002jfj.1_Silent_p.L243L	NM_004655	NP_004646	Q9Y2T1	AXIN2_HUMAN	axin 2	243					cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			central_nervous_system(1)|skin(1)	2														Oligodontia_Ectodermal_Dysplasia_and_Colorectal_Polyp_syndrome				---	---	---	---
KCNJ2	3759	broad.mit.edu	37	17	68171571	68171571	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:68171571G>A	uc010dfg.2	+	2	792	c.391G>A	c.(391-393)GCT>ACT	p.A131T	KCNJ2_uc002jir.2_Missense_Mutation_p.A131T	NM_000891	NP_000882	P63252	IRK2_HUMAN	potassium inwardly-rectifying channel J2	131					synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity|protein binding				0	Breast(10;1.64e-08)																	---	---	---	---
TTYH2	94015	broad.mit.edu	37	17	72227069	72227069	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:72227069C>T	uc002jkc.2	+	3	376	c.345C>T	c.(343-345)AAC>AAT	p.N115N	TTYH2_uc010wqw.1_Silent_p.N94N	NM_032646	NP_116035	Q9BSA4	TTYH2_HUMAN	tweety 2 isoform 1	115	Extracellular (Potential).					chloride channel complex|plasma membrane	chloride channel activity|protein binding			ovary(3)|large_intestine(1)	4																		---	---	---	---
Unknown	0	broad.mit.edu	37	17	76522712	76522712	+	IGR	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:76522712C>A								DNAH17 (53856 upstream) : CYTH1 (147419 downstream)																																			---	---	---	---
DNAH17	8632	broad.mit.edu	37	17	76557880	76557880	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:76557880G>A	uc002jvv.1	-	8	964	c.858C>T	c.(856-858)CCC>CCT	p.P286P						RecName: Full=Dynein heavy chain 17, axonemal; AltName: Full=Axonemal beta dynein heavy chain 17; AltName: Full=Ciliary dynein heavy chain 17; AltName: Full=Ciliary dynein heavy chain-like protein 1; AltName: Full=Axonemal dynein heavy chain-like protein 1; AltName: Full=Dynein light chain 2, axonemal;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)															---	---	---	---
GAA	2548	broad.mit.edu	37	17	78090907	78090907	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:78090907C>T	uc002jxo.2	+	17	2512	c.2330C>T	c.(2329-2331)ACG>ATG	p.T777M	GAA_uc002jxp.2_Missense_Mutation_p.T777M|GAA_uc002jxq.2_Missense_Mutation_p.T777M	NM_001079803	NP_001073271	P10253	LYAG_HUMAN	acid alpha-glucosidase preproprotein	777					cardiac muscle contraction|diaphragm contraction|glycogen catabolic process|lysosome organization|tongue morphogenesis|vacuolar sequestering|ventricular cardiac muscle tissue morphogenesis	lysosomal membrane	carbohydrate binding|maltose alpha-glucosidase activity			ovary(1)	1	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)		Acarbose(DB00284)													---	---	---	---
EIF4A3	9775	broad.mit.edu	37	17	78113460	78113460	+	Intron	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:78113460T>C	uc010wuc.1	-						EIF4A3_uc002jxs.2_Intron	NM_014740	NP_055555			eukaryotic translation initiation factor 4A,						mRNA transport|negative regulation of translation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|rRNA processing	catalytic step 2 spliceosome|cytoplasm|exon-exon junction complex|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|poly(A) RNA binding|protein binding			ovary(1)	1	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)															---	---	---	---
RNF213	57674	broad.mit.edu	37	17	78351588	78351588	+	Missense_Mutation	SNP	G	A	A	rs148541222	byFrequency	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:78351588G>A	uc002jyh.1	+	29	7979	c.7756G>A	c.(7756-7758)GTG>ATG	p.V2586M	uc002jyi.1_Intron|RNF213_uc010dhw.1_Missense_Mutation_p.V968M	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)															---	---	---	---
RNF213	57674	broad.mit.edu	37	17	78356807	78356807	+	Silent	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:78356807A>G	uc002jyh.1	+	33	8449	c.8226A>G	c.(8224-8226)TCA>TCG	p.S2742S	uc002jyi.1_Intron|RNF213_uc010dhw.1_3'UTR	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)															---	---	---	---
RNF213	57674	broad.mit.edu	37	17	78363150	78363150	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:78363150A>G	uc002jyh.1	+	40	9620	c.9397A>G	c.(9397-9399)ACG>GCG	p.T3133A	uc002jyi.1_Intron|RNF213_uc010dhx.1_Missense_Mutation_p.T77A	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)															---	---	---	---
GPS1	2873	broad.mit.edu	37	17	80014934	80014934	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:80014934G>A	uc002kdl.1	+	13	1452	c.1407G>A	c.(1405-1407)CCG>CCA	p.P469P	GPS1_uc002kdk.1_Silent_p.P505P|GPS1_uc010dij.1_Silent_p.P504P|GPS1_uc002kdm.1_Silent_p.P449P|GPS1_uc002kdn.1_Silent_p.P465P|GPS1_uc002kdo.1_Silent_p.P468P|GPS1_uc010wvh.1_Silent_p.P461P	NM_004127	NP_004118	Q13098	CSN1_HUMAN	G protein pathway suppressor 1 isoform 2	469					cell cycle|cullin deneddylation|inactivation of MAPK activity|JNK cascade	cytoplasm|signalosome	GTPase inhibitor activity|protein binding			central_nervous_system(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0211)															---	---	---	---
FASN	2194	broad.mit.edu	37	17	80039558	80039558	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:80039558A>G	uc002kdu.2	-	37	6442	c.6325T>C	c.(6325-6327)TTT>CTT	p.F2109L	FASN_uc002kdv.1_RNA	NM_004104	NP_004095	P49327	FAS_HUMAN	fatty acid synthase	2109	Beta-ketoacyl reductase (By similarity).				energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)													---	---	---	---
ZNF750	79755	broad.mit.edu	37	17	80789385	80789385	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:80789385G>A	uc002kga.2	-	2	1257	c.946C>T	c.(946-948)CCG>TCG	p.P316S	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	316						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)															---	---	---	---
COLEC12	81035	broad.mit.edu	37	18	335158	335158	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:335158C>T	uc002kkm.2	-	6	1615	c.1400G>A	c.(1399-1401)GGA>GAA	p.G467E		NM_130386	NP_569057	Q5KU26	COL12_HUMAN	collectin sub-family member 12	467	Collagen-like 1.|Extracellular (Potential).				carbohydrate mediated signaling|innate immune response|phagocytosis, recognition|protein homooligomerization	collagen|integral to membrane	galactose binding|low-density lipoprotein particle binding|metal ion binding|pattern recognition receptor activity|scavenger receptor activity			ovary(1)|pancreas(1)	2		all_cancers(4;0.0442)|Myeloproliferative disorder(11;0.0426)																---	---	---	---
TUBB6	84617	broad.mit.edu	37	18	12325459	12325459	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:12325459A>T	uc002kqw.2	+	4	716	c.671A>T	c.(670-672)GAC>GTC	p.D224V	TUBB6_uc002kqv.2_Missense_Mutation_p.D152V|TUBB6_uc010dld.2_RNA|TUBB6_uc002kqx.2_Missense_Mutation_p.D187V|TUBB6_uc002kqy.2_Intron	NM_032525	NP_115914	Q9BUF5	TBB6_HUMAN	tubulin, beta 6	224					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity				0				READ - Rectum adenocarcinoma(1;0.0649)														---	---	---	---
ABHD3	171586	broad.mit.edu	37	18	19282375	19282375	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:19282375G>A	uc002ktl.2	-	3	551	c.411C>T	c.(409-411)AGC>AGT	p.S137S	ABHD3_uc002ktm.2_Silent_p.S137S|ABHD3_uc010xao.1_RNA|MIB1_uc002ktp.2_5'Flank|ABHD3_uc002kto.2_Silent_p.S137S	NM_138340	NP_612213	Q8WU67	ABHD3_HUMAN	alpha/beta hydrolase domain containing protein	137						integral to membrane	carboxylesterase activity			central_nervous_system(1)	1																		---	---	---	---
MIB1	57534	broad.mit.edu	37	18	19395628	19395628	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:19395628G>A	uc002ktq.2	+	11	1531	c.1531G>A	c.(1531-1533)GCT>ACT	p.A511T	MIB1_uc002ktp.2_Missense_Mutation_p.A150T	NM_020774	NP_065825	Q86YT6	MIB1_HUMAN	mindbomb homolog 1	511	ANK 3.				Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(4)	4			STAD - Stomach adenocarcinoma(5;0.212)															---	---	---	---
ZNF521	25925	broad.mit.edu	37	18	22804681	22804681	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:22804681G>A	uc002kvk.2	-	4	3448	c.3201C>T	c.(3199-3201)TGC>TGT	p.C1067C	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Silent_p.C1067C|ZNF521_uc002kvl.2_Silent_p.C847C	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	1067	C2H2-type 25; degenerate.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)							T	PAX5	ALL								---	---	---	---
CDH2	1000	broad.mit.edu	37	18	25543417	25543417	+	Silent	SNP	G	A	A	rs144671067		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:25543417G>A	uc002kwg.2	-	15	2877	c.2418C>T	c.(2416-2418)ATC>ATT	p.I806I	CDH2_uc010xbn.1_Silent_p.I775I	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	806	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4																		---	---	---	---
DSG3	1830	broad.mit.edu	37	18	29041180	29041180	+	Intron	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:29041180G>A	uc002kws.2	+							NM_001944	NP_001935			desmoglein 3 preproprotein						cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)															---	---	---	---
DSG2	1829	broad.mit.edu	37	18	29111033	29111033	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:29111033T>C	uc002kwu.3	+	9	1286	c.1098T>C	c.(1096-1098)AGT>AGC	p.S366S		NM_001943	NP_001934	Q14126	DSG2_HUMAN	desmoglein 2 preproprotein	366	Extracellular (Potential).|Cadherin 3.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(2)|breast(1)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.0068)															---	---	---	---
ELP2	55250	broad.mit.edu	37	18	33718382	33718382	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:33718382T>C	uc002kzk.1	+	4	448	c.438T>C	c.(436-438)GGT>GGC	p.G146G	ELP2_uc010xcg.1_Silent_p.G146G|ELP2_uc002kzl.1_RNA|ELP2_uc002kzm.1_Silent_p.G146G|ELP2_uc010xch.1_Silent_p.G146G|ELP2_uc002kzn.1_Silent_p.G146G|ELP2_uc002kzo.1_Silent_p.G146G	NM_018255	NP_060725	Q6IA86	ELP2_HUMAN	elongator protein 2	146	WD 3.				regulation of transcription from RNA polymerase II promoter	Golgi apparatus|transcription elongation factor complex				breast(2)|ovary(1)|skin(1)	4																		---	---	---	---
SETBP1	26040	broad.mit.edu	37	18	42281711	42281711	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:42281711A>G	uc010dni.2	+	2	696	c.400A>G	c.(400-402)AAG>GAG	p.K134E	SETBP1_uc002lay.2_Missense_Mutation_p.K134E	NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	134						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)										Schinzel-Giedion_syndrome				---	---	---	---
SETBP1	26040	broad.mit.edu	37	18	42532057	42532057	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:42532057C>T	uc010dni.2	+	4	3048	c.2752C>T	c.(2752-2754)CGG>TGG	p.R918W		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	918						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)										Schinzel-Giedion_syndrome				---	---	---	---
SIGLEC15	284266	broad.mit.edu	37	18	43418864	43418864	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:43418864G>A	uc002lbl.1	+	4	827	c.678G>A	c.(676-678)CTG>CTA	p.L226L	SIGLEC15_uc010xcp.1_RNA	NM_213602	NP_998767	Q6ZMC9	SIG15_HUMAN	sialic acid binding Ig-like lectin 15 precursor	226	Extracellular (Potential).|Ig-like C2-type.					integral to membrane					0																		---	---	---	---
MYO5B	4645	broad.mit.edu	37	18	47438517	47438517	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:47438517C>T	uc002leb.2	-	18	2405	c.2117G>A	c.(2116-2118)CGG>CAG	p.R706Q		NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	706	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)														---	---	---	---
CCDC11	220136	broad.mit.edu	37	18	47788456	47788456	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:47788456T>C	uc002lee.2	-	2	294	c.203A>G	c.(202-204)CAG>CGG	p.Q68R		NM_145020	NP_659457	Q96M91	CCD11_HUMAN	coiled-coil domain containing 11	68										ovary(1)|pancreas(1)|skin(1)	3				STAD - Stomach adenocarcinoma(97;2.66e-05)|Colorectal(21;7.57e-05)|Lung(128;0.00932)|READ - Rectum adenocarcinoma(32;0.164)														---	---	---	---
CXXC1	30827	broad.mit.edu	37	18	47812478	47812478	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:47812478C>A	uc002leq.3	-	4	1106	c.373G>T	c.(373-375)GGG>TGG	p.G125W	CXXC1_uc002lep.3_Translation_Start_Site|CXXC1_uc002ler.3_Missense_Mutation_p.G125W|CXXC1_uc010doy.2_Missense_Mutation_p.G125W|CXXC1_uc002les.2_Missense_Mutation_p.G125W	NM_014593	NP_055408	Q9P0U4	CXXC1_HUMAN	CXXC finger 1 (PHD domain) isoform 2	125					histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2																		---	---	---	---
DCC	1630	broad.mit.edu	37	18	50976988	50976988	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:50976988C>T	uc002lfe.1	+	23	3935	c.3348C>T	c.(3346-3348)ATC>ATT	p.I1116I	DCC_uc010dpf.1_Silent_p.I751I	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	1116	Helical; (Potential).				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)														---	---	---	---
C18orf26	284254	broad.mit.edu	37	18	52262284	52262284	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:52262284G>T	uc002lfq.1	+	2	296	c.250G>T	c.(250-252)GGA>TGA	p.G84*	C18orf26_uc002lfp.1_Intron	NM_173629	NP_775900	Q8N1N2	CR026_HUMAN	hypothetical protein LOC284254	84						integral to membrane					0				Colorectal(16;0.0193)|READ - Rectum adenocarcinoma(59;0.178)														---	---	---	---
TCF4	6925	broad.mit.edu	37	18	52899750	52899750	+	Splice_Site	SNP	A	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:52899750A>T	uc002lfz.2	-	17	2249	c.1637_splice	c.e17+1	p.S546_splice	TCF4_uc002lfw.3_Missense_Mutation_p.S387T|TCF4_uc010xdu.1_Splice_Site_p.S416_splice|TCF4_uc010xdv.1_Splice_Site_p.S416_splice|TCF4_uc002lfx.2_Missense_Mutation_p.S476T|TCF4_uc010xdw.1_Splice_Site_p.S416_splice|TCF4_uc002lfy.2_Splice_Site_p.S504_splice|TCF4_uc010xdx.1_Splice_Site_p.S522_splice|TCF4_uc010dph.1_Missense_Mutation_p.S547T|TCF4_uc010xdy.1_Missense_Mutation_p.S523T|TCF4_uc002lga.2_Missense_Mutation_p.S649T|TCF4_uc002lgb.1_Splice_Site_p.S386_splice|TCF4_uc010dpi.2_Missense_Mutation_p.S553T|TCF4_uc002lfv.2_Splice_Site_p.S329_splice	NM_003199	NP_003190			transcription factor 4 isoform b						positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding			ovary(1)|lung(1)	2				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)														---	---	---	---
ATP8B1	5205	broad.mit.edu	37	18	55319829	55319829	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:55319829T>C	uc002lgw.2	-	24	3148	c.3148A>G	c.(3148-3150)ATA>GTA	p.I1050V	uc002lgu.1_Intron|uc002lgv.1_Intron	NM_005603	NP_005594	O43520	AT8B1_HUMAN	ATPase, class I, type 8B, member 1	1050	Helical; (Potential).				ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(5)|ovary(2)|central_nervous_system(2)|lung(1)	10		Colorectal(73;0.229)												Byler_disease				---	---	---	---
ZNF532	55205	broad.mit.edu	37	18	56651281	56651281	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:56651281G>A	uc002lho.2	+	11	4036	c.3489G>A	c.(3487-3489)CTG>CTA	p.L1163L	ZNF532_uc002lhp.2_Silent_p.L1161L|ZNF532_uc010xeg.1_Silent_p.L1161L|ZNF532_uc002lhr.2_Silent_p.L1161L|ZNF532_uc002lhs.2_Silent_p.L1161L|ZNF532_uc010xeh.1_Silent_p.L251L	NM_018181	NP_060651	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	1163					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2																		---	---	---	---
KIAA1468	57614	broad.mit.edu	37	18	59933944	59933944	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:59933944A>G	uc002lil.2	+	19	2857	c.2642A>G	c.(2641-2643)CAG>CGG	p.Q881R	KIAA1468_uc002lik.1_Missense_Mutation_p.Q881R|KIAA1468_uc010xel.1_Missense_Mutation_p.Q881R|KIAA1468_uc002lim.2_Missense_Mutation_p.Q525R	NM_020854	NP_065905	Q9P260	K1468_HUMAN	hypothetical protein LOC57614	881							binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)	6		Colorectal(73;0.186)																---	---	---	---
RTTN	25914	broad.mit.edu	37	18	67671383	67671383	+	3'UTR	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:67671383G>A	uc002lkp.2	-	49					RTTN_uc002lko.2_RNA|RTTN_uc010xfb.1_3'UTR|RTTN_uc002lkn.2_3'UTR|RTTN_uc010dqp.2_3'UTR	NM_173630	NP_775901			rotatin								binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)																---	---	---	---
RTTN	25914	broad.mit.edu	37	18	67836277	67836277	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:67836277C>T	uc002lkp.2	-	12	1571	c.1503G>A	c.(1501-1503)ATG>ATA	p.M501I	RTTN_uc002lko.2_RNA|RTTN_uc010xfb.1_Intron|RTTN_uc002lkq.1_Missense_Mutation_p.M501I	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	501							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)																---	---	---	---
ADNP2	22850	broad.mit.edu	37	18	77893685	77893685	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:77893685C>A	uc002lnw.2	+	4	844	c.389C>A	c.(388-390)CCT>CAT	p.P130H		NM_014913	NP_055728	Q6IQ32	ADNP2_HUMAN	ADNP homeobox 2	130					cellular response to oxidative stress|cellular response to retinoic acid|negative regulation of cell death|neuron differentiation|positive regulation of cell growth	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|breast(3)|central_nervous_system(1)	8		all_cancers(4;1.06e-15)|all_epithelial(4;2.36e-10)|all_lung(4;0.000302)|Lung NSC(4;0.000518)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0256)|all_hematologic(56;0.15)|Melanoma(33;0.2)		Epithelial(2;1.1e-11)|OV - Ovarian serous cystadenocarcinoma(15;7.54e-09)|BRCA - Breast invasive adenocarcinoma(31;0.00247)|STAD - Stomach adenocarcinoma(84;0.164)														---	---	---	---
GZMM	3004	broad.mit.edu	37	19	549785	549785	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:549785G>A	uc002low.1	+	5	813	c.768G>A	c.(766-768)TCG>TCA	p.S256S		NM_005317	NP_005308	P51124	GRAM_HUMAN	granzyme M precursor	256					apoptosis|cytolysis|innate immune response|proteolysis	extracellular region	serine-type endopeptidase activity				0		all_cancers(10;1.94e-35)|all_epithelial(18;5.94e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
TLE2	7089	broad.mit.edu	37	19	3005766	3005766	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:3005766G>A	uc002lww.2	-	16	1964	c.1701C>T	c.(1699-1701)AGC>AGT	p.S567S	TLE2_uc010xhb.1_Silent_p.S234S|TLE2_uc010dth.2_Silent_p.S568S|TLE2_uc010xhc.1_Silent_p.S445S|TLE2_uc010dti.2_Silent_p.S581S	NM_003260	NP_003251	Q04725	TLE2_HUMAN	transducin-like enhancer protein 2 isoform 1	567	WD 3.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity				0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
C19orf29	58509	broad.mit.edu	37	19	3619215	3619215	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:3619215G>A	uc002lyh.2	-	5	963	c.910C>T	c.(910-912)CGG>TGG	p.R304W	C19orf29_uc010xho.1_5'UTR|C19orf29_uc010dtn.2_Missense_Mutation_p.R152W|C19orf29_uc002lyi.3_Missense_Mutation_p.R304W|C19orf29_uc010dto.2_RNA|C19orf29_uc010xhp.1_RNA	NM_001080543	NP_001074012	Q8WUQ7	CS029_HUMAN	chromosome 19 open reading frame 29	304						catalytic step 2 spliceosome	protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
CREB3L3	84699	broad.mit.edu	37	19	4154961	4154961	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4154961C>A	uc002lzl.2	+	2	209	c.93C>A	c.(91-93)GAC>GAA	p.D31E	CREB3L3_uc002lzm.2_Missense_Mutation_p.D22E|CREB3L3_uc010xib.1_Missense_Mutation_p.D22E|CREB3L3_uc010xic.1_Missense_Mutation_p.D22E	NM_032607	NP_115996	Q68CJ9	CR3L3_HUMAN	cAMP responsive element binding protein 3-like	31	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0232)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
PLIN4	729359	broad.mit.edu	37	19	4511275	4511275	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4511275G>A	uc002mar.1	-	3	2655	c.2655C>T	c.(2653-2655)TCC>TCT	p.S885S	PLIN4_uc010dub.1_5'UTR	NM_001080400	NP_001073869	Q96Q06	PLIN4_HUMAN	plasma membrane associated protein, S3-12	885	27 X 33 AA approximate tandem repeat.|24.					lipid particle|plasma membrane					0																		---	---	---	---
PLIN4	729359	broad.mit.edu	37	19	4511671	4511671	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4511671G>A	uc002mar.1	-	3	2259	c.2259C>T	c.(2257-2259)TCC>TCT	p.S753S	PLIN4_uc010dub.1_5'Flank	NM_001080400	NP_001073869	Q96Q06	PLIN4_HUMAN	plasma membrane associated protein, S3-12	753	27 X 33 AA approximate tandem repeat.|20.					lipid particle|plasma membrane					0																		---	---	---	---
PLIN5	440503	broad.mit.edu	37	19	4523866	4523866	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4523866C>T	uc002mas.2	-	8	1119	c.1066G>A	c.(1066-1068)GCC>ACC	p.A356T		NM_001013706	NP_001013728	Q00G26	PLIN5_HUMAN	lipid storage droplet protein 5	356						lipid particle					0																		---	---	---	---
PLIN3	10226	broad.mit.edu	37	19	4852236	4852236	+	Silent	SNP	C	T	T	rs35640392		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4852236C>T	uc002mbj.2	-	5	603	c.426G>A	c.(424-426)ACG>ACA	p.T142T	PLIN3_uc002mbk.2_Silent_p.T130T|PLIN3_uc002mbl.3_Silent_p.T142T	NM_005817	NP_005808	O60664	PLIN3_HUMAN	mannose 6 phosphate receptor binding protein 1	142					vesicle-mediated transport	endosome membrane|Golgi apparatus|lipid particle	protein binding				0					Galsulfase(DB01279)|Idursulfase(DB01271)											OREG0025175	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
PTPRS	5802	broad.mit.edu	37	19	5212459	5212459	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:5212459G>A	uc002mbv.2	-	31	4892	c.4658C>T	c.(4657-4659)ACG>ATG	p.T1553M	PTPRS_uc002mbu.1_Missense_Mutation_p.T1122M|PTPRS_uc010xin.1_Missense_Mutation_p.T1095M|PTPRS_uc002mbw.2_Missense_Mutation_p.T1515M|PTPRS_uc002mbx.2_Missense_Mutation_p.T1110M|PTPRS_uc002mby.2_Missense_Mutation_p.T1106M	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	1553	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 1.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)														---	---	---	---
TRIP10	9322	broad.mit.edu	37	19	6742993	6742993	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6742993G>T	uc002mfs.2	+	4	279	c.213G>T	c.(211-213)CAG>CAT	p.Q71H	TRIP10_uc010dux.1_Missense_Mutation_p.Q71H|TRIP10_uc002mfr.2_Missense_Mutation_p.Q71H|TRIP10_uc010duy.2_RNA|TRIP10_uc010duz.2_Intron	NM_004240	NP_004231	Q15642	CIP4_HUMAN	thyroid hormone receptor interactor 10	71	Required for podosome formation and interaction with AKAP9 and microtubules.|Induction of membrane tubulation.|Required for translocation to the plasma membrane in response to insulin (By similarity).				actin cytoskeleton organization|cell communication|endocytosis|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell projection|cytoskeleton|cytosol|Golgi apparatus|lysosome|perinuclear region of cytoplasm|phagocytic cup	GTPase activator activity|identical protein binding|lipid binding			ovary(1)	1																		---	---	---	---
PNPLA6	10908	broad.mit.edu	37	19	7621376	7621376	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:7621376C>T	uc010xjq.1	+	27	3356	c.3161C>T	c.(3160-3162)ACG>ATG	p.T1054M	PNPLA6_uc002mgq.1_Missense_Mutation_p.T1006M|PNPLA6_uc010xjp.1_Missense_Mutation_p.T979M|PNPLA6_uc002mgr.1_Missense_Mutation_p.T1006M|PNPLA6_uc002mgs.2_Missense_Mutation_p.T1044M|PNPLA6_uc002mgt.1_RNA	NM_006702	NP_006693	Q8IY17	PLPL6_HUMAN	neuropathy target esterase isoform b	1045	Patatin.|Cytoplasmic (Potential).				cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			ovary(3)	3																		---	---	---	---
XAB2	56949	broad.mit.edu	37	19	7692684	7692684	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:7692684C>T	uc002mgx.2	-	3	280	c.254G>A	c.(253-255)CGC>CAC	p.R85H	uc010dvi.1_5'Flank	NM_020196	NP_064581	Q9HCS7	SYF1_HUMAN	XPA binding protein 2	85					transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	catalytic step 2 spliceosome|nucleoplasm	protein binding			central_nervous_system(2)|breast(1)|skin(1)	4													Direct_reversal_of_damage|NER					---	---	---	---
MARCH2	51257	broad.mit.edu	37	19	8491690	8491690	+	Splice_Site	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:8491690T>C	uc002mjv.2	+	4	813	c.372_splice	c.e4+2	p.E124_splice	MARCH2_uc002mjw.2_Splice_Site_p.E124_splice|MARCH2_uc002mjx.2_Splice_Site_p.E124_splice	NM_016496	NP_057580			membrane-associated ring finger (C3HC4) 2						endocytosis	cytoplasmic vesicle|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2																		---	---	---	---
MUC16	94025	broad.mit.edu	37	19	9083944	9083944	+	Missense_Mutation	SNP	G	A	A	rs144088703	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9083944G>A	uc002mkp.2	-	1	8075	c.7871C>T	c.(7870-7872)ACG>ATG	p.T2624M		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2624	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57																		---	---	---	---
DNMT1	1786	broad.mit.edu	37	19	10257153	10257153	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10257153A>G	uc002mng.2	-	27	2900	c.2720T>C	c.(2719-2721)ATC>ACC	p.I907T	DNMT1_uc002mnf.2_5'Flank|DNMT1_uc010xlc.1_Missense_Mutation_p.I923T|DNMT1_uc002mnh.2_Missense_Mutation_p.I802T|DNMT1_uc010xld.1_Missense_Mutation_p.I907T	NM_001379	NP_001370	P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1 isoform b	907					chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			ovary(2)|prostate(1)|lung(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)													---	---	---	---
ICAM4	3386	broad.mit.edu	37	19	10398355	10398355	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10398355C>A	uc002mns.1	+	2	577	c.538C>A	c.(538-540)CTG>ATG	p.L180M	ICAM4_uc002mnr.1_Missense_Mutation_p.P154H|ICAM4_uc002mnt.1_Missense_Mutation_p.L180M|ICAM5_uc002mnu.3_5'Flank	NM_001544	NP_001535	Q14773	ICAM4_HUMAN	intercellular adhesion molecule 4 isoform 1	180	Ig-like C2-type 2.|Extracellular (Potential).				cell-cell adhesion|regulation of immune response	extracellular region|integral to membrane|plasma membrane	integrin binding			lung(1)	1			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)															---	---	---	---
TYK2	7297	broad.mit.edu	37	19	10479000	10479000	+	Silent	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10479000A>G	uc002moc.3	-	4	666	c.288T>C	c.(286-288)GAT>GAC	p.D96D	TYK2_uc010dxe.2_Intron|TYK2_uc002mod.2_Silent_p.D96D	NM_003331	NP_003322	P29597	TYK2_HUMAN	tyrosine kinase 2	96	FERM.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|large_intestine(2)|ovary(1)|breast(1)	9			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)															---	---	---	---
SMARCA4	6597	broad.mit.edu	37	19	11145784	11145784	+	Silent	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:11145784A>G	uc002mqf.3	+	29	4430	c.4146A>G	c.(4144-4146)TCA>TCG	p.S1382S	SMARCA4_uc010dxp.2_Silent_p.S1382S|SMARCA4_uc010dxo.2_Silent_p.S1382S|SMARCA4_uc010dxq.2_Silent_p.S1349S|SMARCA4_uc010dxr.2_Silent_p.S1349S|SMARCA4_uc002mqj.3_Silent_p.S1349S|SMARCA4_uc010dxs.2_Silent_p.S1349S|SMARCA4_uc010dxt.1_Silent_p.S569S|SMARCA4_uc002mqh.3_Silent_p.S472S|SMARCA4_uc002mqi.1_Silent_p.S552S	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	1382					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity			lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)						F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				---	---	---	---
KANK2	25959	broad.mit.edu	37	19	11303705	11303705	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:11303705C>T	uc010dxv.2	-	6	1609	c.1051G>A	c.(1051-1053)GCA>ACA	p.A351T	KANK2_uc002mqm.2_Missense_Mutation_p.A351T|KANK2_uc002mqo.3_Missense_Mutation_p.A351T|KANK2_uc002mqp.1_Missense_Mutation_p.A160T|KANK2_uc002mqq.2_Missense_Mutation_p.A351T	NM_015493	NP_056308	Q63ZY3	KANK2_HUMAN	ankyrin repeat domain 25 isoform 1	351											0																		---	---	---	---
RGL3	57139	broad.mit.edu	37	19	11512883	11512883	+	Intron	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:11512883C>A	uc002mrp.2	-						RGL3_uc002mrn.2_Intron|RGL3_uc002mrm.2_Intron|RGL3_uc002mro.2_Intron	NM_001035223	NP_001030300			ral guanine nucleotide dissociation						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular				ovary(1)	1																		---	---	---	---
ELAVL3	1995	broad.mit.edu	37	19	11569310	11569310	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:11569310G>A	uc002mry.1	-	4	830	c.450C>T	c.(448-450)CGC>CGT	p.R150R	ELAVL3_uc002mrx.1_Silent_p.R150R	NM_001420	NP_001411	Q14576	ELAV3_HUMAN	ELAV-like protein 3 isoform 1	150	RRM 2.				cell differentiation|nervous system development		AU-rich element binding|nucleotide binding			ovary(1)|breast(1)|skin(1)	3																		---	---	---	---
MAN2B1	4125	broad.mit.edu	37	19	12772078	12772078	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:12772078G>A	uc002mub.2	-	7	1098	c.1022C>T	c.(1021-1023)GCG>GTG	p.A341V	MAN2B1_uc010dyv.1_Missense_Mutation_p.A341V	NM_000528	NP_000519	O00754	MA2B1_HUMAN	mannosidase, alpha, class 2B, member 1	341					protein deglycosylation	lysosome	alpha-mannosidase activity|zinc ion binding			ovary(4)|central_nervous_system(2)	6																		---	---	---	---
TNPO2	30000	broad.mit.edu	37	19	12830070	12830070	+	Intron	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:12830070C>T	uc002muo.2	-						TNPO2_uc002mup.2_Intron|TNPO2_uc002muq.2_Intron|TNPO2_uc002mur.2_Intron	NM_001136196	NP_001129668			transportin 2 (importin 3, karyopherin beta 2b)						intracellular protein transport	cytoplasm|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			ovary(1)	1																		---	---	---	---
HOOK2	29911	broad.mit.edu	37	19	12883718	12883718	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:12883718C>T	uc002muy.2	-	5	435	c.264G>A	c.(262-264)GCG>GCA	p.A88A	HOOK2_uc002muz.2_Silent_p.A88A	NM_013312	NP_037444	Q96ED9	HOOK2_HUMAN	hook homolog 2 isoform 1	88	Sufficient for interaction with microtubules.|Required for localization to the centrosome and induction of aggresome formation.				early endosome to late endosome transport|endocytosis|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|protein transport	centrosome|FHF complex|microtubule	identical protein binding|microtubule binding			ovary(1)|breast(1)|skin(1)	3																		---	---	---	---
SYCE2	256126	broad.mit.edu	37	19	13010838	13010838	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:13010838C>T	uc002mvr.2	-	5	607	c.592G>A	c.(592-594)GTG>ATG	p.V198M		NM_001105578	NP_001099048	Q6PIF2	SYCE2_HUMAN	synaptonemal complex central element protein 2	198					cell division	central element					0																		---	---	---	---
CCDC130	81576	broad.mit.edu	37	19	13869829	13869829	+	Intron	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:13869829G>T	uc002mxb.1	+						CCDC130_uc010xnf.1_Missense_Mutation_p.E135D|CCDC130_uc002mxc.1_Intron|CCDC130_uc002mxd.1_5'UTR|CCDC130_uc010dzf.1_Intron	NM_030818	NP_110445			coiled-coil domain containing 130						response to virus		protein binding				0			OV - Ovarian serous cystadenocarcinoma(19;6.02e-23)|Epithelial(5;2.58e-18)															---	---	---	---
NANOS3	342977	broad.mit.edu	37	19	13985688	13985688	+	5'Flank	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:13985688C>T	uc002mxj.3	+						MIR181D_hsa-mir-181d|MI0003139_5'Flank|uc010dzg.1_5'Flank	NM_001098622	NP_001092092			nanos homolog 3						anti-apoptosis|germ cell development|multicellular organismal development|oogenesis|regulation of cell cycle|regulation of translation|spermatogenesis	cytoplasmic mRNA processing body|nucleus|stress granule	RNA binding|zinc ion binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(19;2e-21)															---	---	---	---
RFX1	5989	broad.mit.edu	37	19	14090271	14090271	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:14090271G>A	uc002mxv.2	-	7	1094	c.822C>T	c.(820-822)CAC>CAT	p.H274H	RFX1_uc010dzi.2_Silent_p.H274H	NM_002918	NP_002909	P22670	RFX1_HUMAN	regulatory factor X1	274					immune response	nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			lung(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(19;6.67e-23)															---	---	---	---
LPHN1	22859	broad.mit.edu	37	19	14273457	14273457	+	Missense_Mutation	SNP	G	A	A	rs138963845		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:14273457G>A	uc010xnn.1	-	6	1467	c.1171C>T	c.(1171-1173)CGC>TGC	p.R391C	LPHN1_uc010xno.1_Missense_Mutation_p.R386C|uc002myf.2_Intron	NM_001008701	NP_001008701	O94910	LPHN1_HUMAN	latrophilin 1 isoform 1 precursor	391	Olfactomedin-like.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			ovary(2)|lung(2)|central_nervous_system(1)	5																		---	---	---	---
SLC1A6	6511	broad.mit.edu	37	19	15082660	15082660	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:15082660G>A	uc002naa.1	-	2	240	c.232C>T	c.(232-234)CCA>TCA	p.P78S	SLC1A6_uc010dzu.1_Missense_Mutation_p.P78S|SLC1A6_uc010xod.1_Missense_Mutation_p.P82L|SLC1A6_uc002nab.2_Missense_Mutation_p.P78S|SLC1A6_uc002nac.2_Missense_Mutation_p.P78S|SLC1A6_uc002nad.1_Missense_Mutation_p.P78S	NM_005071	NP_005062	P48664	EAA4_HUMAN	solute carrier family 1 (high affinity	78					synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			pancreas(3)|ovary(2)|skin(1)	6					L-Glutamic Acid(DB00142)													---	---	---	---
SYDE1	85360	broad.mit.edu	37	19	15224480	15224480	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:15224480C>T	uc002nah.1	+	8	1945	c.1914C>T	c.(1912-1914)CGC>CGT	p.R638R	SYDE1_uc002nai.1_Silent_p.R571R|SYDE1_uc002naj.1_Silent_p.R295R	NM_033025	NP_149014	Q6ZW31	SYDE1_HUMAN	synapse defective 1, Rho GTPase, homolog 1	638					activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			ovary(1)|pancreas(1)	2																		---	---	---	---
AKAP8	10270	broad.mit.edu	37	19	15479059	15479059	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:15479059G>A	uc002nav.2	-	9	1208	c.1147C>T	c.(1147-1149)CGT>TGT	p.R383C	AKAP8_uc010dzy.2_5'UTR|AKAP8_uc010dzz.1_RNA|AKAP8_uc010xog.1_Missense_Mutation_p.R197C	NM_005858	NP_005849	O43823	AKAP8_HUMAN	A-kinase anchor protein 8	383					signal transduction	nuclear matrix				ovary(1)|breast(1)	2																		---	---	---	---
PGLYRP2	114770	broad.mit.edu	37	19	15582709	15582709	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:15582709G>A	uc002nbf.3	-	3	1468	c.1335C>T	c.(1333-1335)ATC>ATT	p.I445I	PGLYRP2_uc002nbg.3_Silent_p.I445I	NM_052890	NP_443122	Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2 precursor	445					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(3)	3																		---	---	---	---
CYP4F22	126410	broad.mit.edu	37	19	15640536	15640536	+	Missense_Mutation	SNP	C	T	T	rs116743462	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:15640536C>T	uc002nbh.3	+	4	406	c.239C>T	c.(238-240)GCG>GTG	p.A80V		NM_173483	NP_775754	Q6NT55	CP4FN_HUMAN	cytochrome P450, family 4, subfamily F,	80						endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			ovary(1)|pancreas(1)	2																		---	---	---	---
OR10H5	284433	broad.mit.edu	37	19	15905054	15905054	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:15905054C>A	uc010xos.1	+	1	196	c.196C>A	c.(196-198)CTC>ATC	p.L66I		NM_001004466	NP_001004466	Q8NGA6	O10H5_HUMAN	olfactory receptor, family 10, subfamily H,	66	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1																		---	---	---	---
CPAMD8	27151	broad.mit.edu	37	19	17036177	17036177	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17036177C>T	uc002nfb.2	-	26	3549	c.3517G>A	c.(3517-3519)GTC>ATC	p.V1173I		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	1126						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13																		---	---	---	---
MYO9B	4650	broad.mit.edu	37	19	17298813	17298813	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17298813C>T	uc010eak.2	+	19	2799	c.2647C>T	c.(2647-2649)CGC>TGC	p.R883C	MYO9B_uc002nfi.2_Missense_Mutation_p.R883C|MYO9B_uc002nfj.1_Missense_Mutation_p.R883C	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	883	Myosin head-like.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1																		---	---	---	---
ARRDC2	27106	broad.mit.edu	37	19	18120836	18120836	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:18120836C>G	uc002nhv.2	+	5	980	c.837C>G	c.(835-837)GAC>GAG	p.D279E	ARRDC2_uc002nhu.2_Missense_Mutation_p.D274E	NM_015683	NP_056498	Q8TBH0	ARRD2_HUMAN	arrestin domain containing 2 isoform 1	279										pancreas(1)	1																		---	---	---	---
KLHL26	55295	broad.mit.edu	37	19	18779651	18779651	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:18779651G>A	uc002njz.1	+	3	1471	c.1444G>A	c.(1444-1446)GAC>AAC	p.D482N		NM_018316	NP_060786	Q53HC5	KLH26_HUMAN	kelch-like 26	482	Kelch 4.									ovary(1)	1																		---	---	---	---
SF4	57794	broad.mit.edu	37	19	19388563	19388563	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19388563G>A	uc002nmh.2	-	12	1763	c.1761C>T	c.(1759-1761)GGC>GGT	p.G587G	SF4_uc002nmf.2_Silent_p.G137G|SF4_uc002nmg.2_Silent_p.G137G|SF4_uc002nmi.2_Silent_p.G377G|SF4_uc002nmj.2_Silent_p.G377G|SF4_uc002nme.2_Silent_p.G137G	NM_172231	NP_757386	Q8IWZ8	SUGP1_HUMAN	splicing factor 4	587	G-patch.				nuclear mRNA splicing, via spliceosome	nucleoplasm|spliceosomal complex	RNA binding				0																		---	---	---	---
CILP2	148113	broad.mit.edu	37	19	19654065	19654065	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19654065A>G	uc002nmv.3	+	7	1071	c.986A>G	c.(985-987)AAT>AGT	p.N329S	CILP2_uc002nmw.3_Missense_Mutation_p.N335S	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	329	Ig-like C2-type.					proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1																		---	---	---	---
GMIP	51291	broad.mit.edu	37	19	19741100	19741100	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19741100C>T	uc002nnd.2	-	21	2702	c.2585G>A	c.(2584-2586)CGT>CAT	p.R862H	LPAR2_uc002nnb.3_5'Flank|LPAR2_uc002nna.3_5'Flank|LPAR2_uc002nnc.3_5'Flank|GMIP_uc010xrb.1_Missense_Mutation_p.R836H|GMIP_uc010xrc.1_Missense_Mutation_p.R833H	NM_016573	NP_057657	Q9P107	GMIP_HUMAN	GEM interacting protein	862					negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			ovary(1)	1																		---	---	---	---
ZNF675	171392	broad.mit.edu	37	19	23836431	23836431	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:23836431C>T	uc002nri.2	-	4	1486	c.1304G>A	c.(1303-1305)CGA>CAA	p.R435Q		NM_138330	NP_612203	Q8TD23	ZN675_HUMAN	zinc finger protein 675	435	C2H2-type 11.				bone resorption|cytokine-mediated signaling pathway|hemopoiesis|I-kappaB kinase/NF-kappaB cascade|negative regulation of JNK cascade|negative regulation of osteoclast differentiation|negative regulation of protein kinase activity|negative regulation of transcription, DNA-dependent|regulation of ossification|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|kidney(1)	2		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)																---	---	---	---
UQCRFS1	7386	broad.mit.edu	37	19	29698468	29698468	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:29698468A>G	uc002nsd.2	-	2	923	c.812T>C	c.(811-813)GTG>GCG	p.V271A		NM_006003	NP_005994	P47985	UCRI_HUMAN	ubiquinol-cytochrome c reductase, Rieske	271	Rieske.				respiratory electron transport chain	integral to membrane|mitochondrial respiratory chain complex III	2 iron, 2 sulfur cluster binding|metal ion binding|ubiquinol-cytochrome-c reductase activity				0	Breast(6;0.0545)|Esophageal squamous(110;0.239)		Lung(7;0.092)															---	---	---	---
LRP3	4037	broad.mit.edu	37	19	33693789	33693789	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:33693789C>T	uc010edh.2	+	3	250	c.157C>T	c.(157-159)CGG>TGG	p.R53W	LRP3_uc010xrp.1_5'UTR|LRP3_uc002nuk.3_5'Flank	NM_002333	NP_002324	O75074	LRP3_HUMAN	low density lipoprotein receptor-related protein	53	Extracellular (Potential).|CUB 1.				receptor-mediated endocytosis	coated pit|integral to membrane	receptor activity			pancreas(2)|ovary(1)	3	Esophageal squamous(110;0.137)																	---	---	---	---
CHST8	64377	broad.mit.edu	37	19	34263795	34263795	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:34263795C>A	uc002nus.3	+	5	1607	c.1102C>A	c.(1102-1104)CTG>ATG	p.L368M	CHST8_uc002nut.3_Missense_Mutation_p.L368M|CHST8_uc002nuu.2_Missense_Mutation_p.L368M	NM_001127895	NP_001121367	Q9H2A9	CHST8_HUMAN	carbohydrate (N-acetylgalactosamine 4-0)	368	Lumenal (Potential).				carbohydrate biosynthetic process|central nervous system development|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			skin(2)|large_intestine(1)|ovary(1)	4	Esophageal squamous(110;0.162)																	---	---	---	---
KCTD15	79047	broad.mit.edu	37	19	34292185	34292185	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:34292185C>T	uc002nuy.3	+	4	448	c.180C>T	c.(178-180)ATC>ATT	p.I60I	KCTD15_uc002nuv.2_Silent_p.I60I|KCTD15_uc002nuw.3_Silent_p.I60I|KCTD15_uc010xrt.1_Silent_p.I60I|KCTD15_uc002nux.3_Silent_p.I60I	NM_001129994	NP_001123466	Q96SI1	KCD15_HUMAN	potassium channel tetramerisation domain	60	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			pancreas(1)	1	Esophageal squamous(110;0.162)																	---	---	---	---
KIAA0355	9710	broad.mit.edu	37	19	34791601	34791601	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:34791601G>A	uc002nvd.3	+	2	1082	c.223G>A	c.(223-225)GAC>AAC	p.D75N	KIAA0355_uc010edk.1_Missense_Mutation_p.D65N	NM_014686	NP_055501	O15063	K0355_HUMAN	hypothetical protein LOC9710	75										ovary(1)	1	Esophageal squamous(110;0.162)																	---	---	---	---
ATP4A	495	broad.mit.edu	37	19	36049337	36049337	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36049337C>T	uc002oal.1	-	10	1456	c.1427G>A	c.(1426-1428)GGC>GAC	p.G476D	ATP4A_uc010eee.1_5'Flank	NM_000704	NP_000695	P20648	ATP4A_HUMAN	hydrogen/potassium-exchanging ATPase 4A	476	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			ovary(1)	1	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)													---	---	---	---
MLL4	9757	broad.mit.edu	37	19	36215889	36215889	+	Splice_Site	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36215889G>T	uc010eei.2	+	11	3430	c.3430_splice	c.e11-1	p.D1144_splice		NM_014727	NP_055542			myeloid/lymphoid or mixed-lineage leukemia 4						chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)															---	---	---	---
MLL4	9757	broad.mit.edu	37	19	36223476	36223476	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36223476C>T	uc010eei.2	+	29	6026	c.6026C>T	c.(6025-6027)GCC>GTC	p.A2009V		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	2009					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)															---	---	---	---
ARHGAP33	115703	broad.mit.edu	37	19	36269357	36269357	+	Intron	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36269357C>T	uc002obr.1	+						ARHGAP33_uc002obs.1_Intron|ARHGAP33_uc002obt.1_Intron|ARHGAP33_uc010eek.1_Intron	NM_052948	NP_443180			sorting nexin 26						cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			skin(2)|ovary(1)|pancreas(1)	4																		---	---	---	---
LRFN3	79414	broad.mit.edu	37	19	36430917	36430917	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36430917C>T	uc002oco.2	+	2	1042	c.590C>T	c.(589-591)GCC>GTC	p.A197V		NM_024509	NP_078785	Q9BTN0	LRFN3_HUMAN	leucine rich repeat and fibronectin type III	197	Extracellular (Potential).|LRR 6.			Missing (in Ref. 2; AAQ88494).	cell adhesion	axon|cell junction|dendrite|integral to membrane|postsynaptic membrane|presynaptic membrane					0	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)															---	---	---	---
ZNF585B	92285	broad.mit.edu	37	19	37676764	37676764	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:37676764A>G	uc002ofq.2	-	5	1929	c.1675T>C	c.(1675-1677)TTC>CTC	p.F559L	uc002ofp.1_5'Flank|ZNF585B_uc002ofr.1_Missense_Mutation_p.F373L	NM_152279	NP_689492	Q52M93	Z585B_HUMAN	zinc finger protein 585B	559	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)															---	---	---	---
SIPA1L3	23094	broad.mit.edu	37	19	38597247	38597247	+	Silent	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:38597247C>A	uc002ohk.2	+	7	2609	c.2100C>A	c.(2098-2100)ACC>ACA	p.T700T		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	700	Rap-GAP.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)															---	---	---	---
LGALS7B	653499	broad.mit.edu	37	19	39281375	39281375	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:39281375G>A	uc002ojf.3	+	3	159	c.142G>A	c.(142-144)GCC>ACC	p.A48T		NM_001042507	NP_001035972	P47929	LEG7_HUMAN	galectin-7B	48	Galectin.				apoptosis|heterophilic cell-cell adhesion	cytoplasm|extracellular space|nucleus	sugar binding				0																		---	---	---	---
NCCRP1	342897	broad.mit.edu	37	19	39690989	39690989	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:39690989C>T	uc002okq.1	+	5	571	c.552C>T	c.(550-552)TTC>TTT	p.F184F		NM_001001414	NP_001001414	Q6ZVX7	NCRP1_HUMAN	non-specific cytotoxic cell receptor protein 1	184	FBA.				protein catabolic process					ovary(1)	1																		---	---	---	---
DYRK1B	9149	broad.mit.edu	37	19	40321029	40321029	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:40321029C>A	uc002omj.2	-	4	638	c.358G>T	c.(358-360)GGC>TGC	p.G120C	DYRK1B_uc002omi.2_Missense_Mutation_p.G120C|DYRK1B_uc002omk.2_Missense_Mutation_p.G120C|DYRK1B_uc002oml.2_Missense_Mutation_p.G120C	NM_004714	NP_004705	Q9Y463	DYR1B_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	120	ATP (By similarity).|Protein kinase.				positive regulation of transcription, DNA-dependent	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|transcription coactivator activity			ovary(4)|stomach(1)|central_nervous_system(1)|skin(1)	7	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)		Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)															---	---	---	---
DYRK1B	9149	broad.mit.edu	37	19	40321086	40321086	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:40321086C>T	uc002omj.2	-	4	581	c.301G>A	c.(301-303)GTG>ATG	p.V101M	DYRK1B_uc002omi.2_Missense_Mutation_p.V101M|DYRK1B_uc002omk.2_Missense_Mutation_p.V101M|DYRK1B_uc002oml.2_Missense_Mutation_p.V101M	NM_004714	NP_004705	Q9Y463	DYR1B_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	101					positive regulation of transcription, DNA-dependent	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|transcription coactivator activity			ovary(4)|stomach(1)|central_nervous_system(1)|skin(1)	7	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)		Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)															---	---	---	---
DYRK1B	9149	broad.mit.edu	37	19	40321350	40321350	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:40321350C>T	uc002omj.2	-	3	417	c.137G>A	c.(136-138)CGT>CAT	p.R46H	DYRK1B_uc002omi.2_Missense_Mutation_p.R46H|DYRK1B_uc002omk.2_Missense_Mutation_p.R46H|DYRK1B_uc002oml.2_Missense_Mutation_p.R46H	NM_004714	NP_004705	Q9Y463	DYR1B_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	46					positive regulation of transcription, DNA-dependent	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|transcription coactivator activity			ovary(4)|stomach(1)|central_nervous_system(1)|skin(1)	7	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)		Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)															---	---	---	---
FCGBP	8857	broad.mit.edu	37	19	40434017	40434017	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:40434017G>A	uc002omp.3	-	2	260	c.252C>T	c.(250-252)CCC>CCT	p.P84P		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	84	IgGFc-binding.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)															---	---	---	---
ZNF780B	163131	broad.mit.edu	37	19	40541678	40541678	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:40541678C>T	uc002omu.2	-	5	1153	c.1088G>A	c.(1087-1089)TGC>TAC	p.C363Y	ZNF780B_uc002omv.2_Missense_Mutation_p.C215Y	NM_001005851	NP_001005851	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	363	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)																	---	---	---	---
PRX	57716	broad.mit.edu	37	19	40900414	40900414	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:40900414G>A	uc002onr.2	-	7	4114	c.3845C>T	c.(3844-3846)TCG>TTG	p.S1282L	PRX_uc002onq.2_Missense_Mutation_p.S1143L|PRX_uc002ons.2_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	1282					axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)															---	---	---	---
LTBP4	8425	broad.mit.edu	37	19	41113279	41113279	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41113279G>A	uc002ooh.1	+	10	1201	c.1201G>A	c.(1201-1203)GTG>ATG	p.V401M	LTBP4_uc002oog.1_Missense_Mutation_p.V364M|LTBP4_uc002ooi.1_Missense_Mutation_p.V334M|LTBP4_uc002ooj.1_5'Flank|LTBP4_uc010xvo.1_5'Flank	NM_001042544	NP_001036009	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding	401					growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)															---	---	---	---
CYP2F1	1572	broad.mit.edu	37	19	41627521	41627521	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41627521G>A	uc002opu.1	+	5	699	c.643G>A	c.(643-645)GAG>AAG	p.E215K	CYP2F1_uc010xvw.1_Intron|CYP2F1_uc010xvv.1_Missense_Mutation_p.E215K|CYP2F1_uc002opv.1_RNA	NM_000774	NP_000765	P24903	CP2F1_HUMAN	cytochrome P450, family 2, subfamily F,	215					naphthalene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0																		---	---	---	---
EXOSC5	56915	broad.mit.edu	37	19	41893465	41893465	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41893465C>T	uc002oqo.2	-	5	592	c.569G>A	c.(568-570)CGG>CAG	p.R190Q	CYP2F1_uc010xvw.1_Intron|BCKDHA_uc002oqm.3_Intron	NM_020158	NP_064543	Q9NQT4	EXOS5_HUMAN	exosome component Rrp46	190					DNA deamination|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5'-exoribonuclease activity|protein binding|RNA binding				0																		---	---	---	---
ATP1A3	478	broad.mit.edu	37	19	42473602	42473602	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42473602A>T	uc002osg.2	-	19	2827	c.2673T>A	c.(2671-2673)AGT>AGA	p.S891R	ATP1A3_uc010xwf.1_Missense_Mutation_p.S902R|ATP1A3_uc010xwg.1_Missense_Mutation_p.S861R|ATP1A3_uc010xwh.1_Missense_Mutation_p.S904R|ATP1A3_uc002osh.2_Missense_Mutation_p.S891R	NM_152296	NP_689509	P13637	AT1A3_HUMAN	Na+/K+ -ATPase alpha 3 subunit	891	Extracellular (Potential).				ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(1)|pancreas(1)	2																		---	---	---	---
PAFAH1B3	5050	broad.mit.edu	37	19	42804110	42804110	+	Intron	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42804110C>A	uc002otg.2	-						PAFAH1B3_uc010xwi.1_Intron|PAFAH1B3_uc010xwj.1_Intron|PRR19_uc002oth.1_5'Flank|PRR19_uc002oti.2_5'Flank	NM_002573	NP_002564			platelet-activating factor acetylhydrolase,						lipid catabolic process|nervous system development	cytoplasm	1-alkyl-2-acetylglycerophosphocholine esterase activity|protein binding				0		Prostate(69;0.0704)																---	---	---	---
CXCL17	284340	broad.mit.edu	37	19	42946996	42946996	+	5'UTR	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42946996G>A	uc002otu.2	-	1					uc010eif.1_Intron|uc002ott.1_Intron|uc010eig.1_Intron|uc010eih.1_Intron	NM_198477	NP_940879			chemokine (C-X-C motif) ligand 17 precursor						angiogenesis|cell differentiation|chemotaxis	extracellular region					0		Prostate(69;0.00899)																---	---	---	---
PSG2	5670	broad.mit.edu	37	19	43576030	43576030	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:43576030G>A	uc002ovr.2	-	4	879	c.786C>T	c.(784-786)TTC>TTT	p.F262F	PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG2_uc002ovq.3_Silent_p.F262F|PSG2_uc010eiq.1_Silent_p.F262F|PSG2_uc002ovs.3_Silent_p.F262F|PSG2_uc002ovt.3_Silent_p.F262F	NM_031246	NP_112536	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	262	Ig-like C2-type 2.				cell migration|female pregnancy	extracellular region					0		Prostate(69;0.00682)																---	---	---	---
BCAM	4059	broad.mit.edu	37	19	45315412	45315412	+	Intron	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:45315412G>A	uc002ozu.2	+						BCAM_uc002ozt.1_Intron	NM_005581	NP_005572			basal cell adhesion molecule isoform 1						cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			skin(1)	1	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)																---	---	---	---
RTN2	6253	broad.mit.edu	37	19	45989049	45989049	+	Intron	SNP	T	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:45989049T>G	uc002pcb.2	-						RTN2_uc002pcc.2_Intron|RTN2_uc002pcd.2_Intron	NM_005619	NP_005610			reticulon 2 isoform A							integral to endoplasmic reticulum membrane	signal transducer activity			ovary(3)	3		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00829)|Epithelial(262;0.184)|GBM - Glioblastoma multiforme(486;0.246)												OREG0025555	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
OPA3	80207	broad.mit.edu	37	19	46087972	46087972	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:46087972C>T	uc002pck.3	-	1	151	c.51G>A	c.(49-51)CGG>CGA	p.R17R	OPA3_uc002pcj.3_Silent_p.R17R|OPA3_uc010xxk.1_Intron	NM_025136	NP_079412	Q9H6K4	OPA3_HUMAN	OPA3 protein isoform b	17					response to stimulus|visual perception	mitochondrion					0		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00778)|GBM - Glioblastoma multiforme(486;0.0976)|Epithelial(262;0.242)														---	---	---	---
EML2	24139	broad.mit.edu	37	19	46128026	46128026	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:46128026G>A	uc002pcn.2	-	9	827	c.792C>T	c.(790-792)GGC>GGT	p.G264G	EML2_uc002pco.2_RNA|EML2_uc002pcp.2_Silent_p.G148G|EML2_uc010xxl.1_Silent_p.G411G|EML2_uc010xxm.1_Silent_p.G465G|EML2_uc010xxn.1_RNA|EML2_uc010xxo.1_Silent_p.G264G|EML2_uc010ekj.2_Intron|EML2_uc010ekk.1_RNA	NM_012155	NP_036287	O95834	EMAL2_HUMAN	echinoderm microtubule associated protein like	264	WD 4.				sensory perception of sound|visual perception	cytoplasm|intracellular membrane-bounded organelle|microtubule|microtubule associated complex	catalytic activity|protein binding			large_intestine(1)|ovary(1)	2		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00553)|GBM - Glioblastoma multiforme(486;0.131)|Epithelial(262;0.197)														---	---	---	---
SNRPD2	6633	broad.mit.edu	37	19	46190926	46190926	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:46190926C>T	uc002pcw.2	-	3	539	c.242G>A	c.(241-243)GGC>GAC	p.G81D	SNRPD2_uc002pcv.2_Missense_Mutation_p.G71D	NM_004597	NP_004588	P62316	SMD2_HUMAN	small nuclear ribonucleoprotein D2 isoform 1	81					ncRNA metabolic process|spliceosomal snRNP assembly|spliceosome assembly	catalytic step 2 spliceosome|cytosol|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	protein binding				0		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00546)|GBM - Glioblastoma multiforme(486;0.0807)|Epithelial(262;0.194)														---	---	---	---
CCDC61	729440	broad.mit.edu	37	19	46509893	46509893	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:46509893G>A	uc002pdw.2	+	5	479	c.479G>A	c.(478-480)CGC>CAC	p.R160H		NM_001080402	NP_001073871			coiled-coil domain containing 61											ovary(1)	1		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00221)|GBM - Glioblastoma multiforme(486;0.0233)|Epithelial(262;0.164)														---	---	---	---
PRKD2	25865	broad.mit.edu	37	19	47197162	47197162	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:47197162C>T	uc002pfh.2	-	11	1888	c.1546G>A	c.(1546-1548)GCA>ACA	p.A516T	PRKD2_uc010ekt.2_5'Flank|PRKD2_uc002pfe.2_Missense_Mutation_p.A36T|PRKD2_uc002pff.2_Missense_Mutation_p.A36T|PRKD2_uc002pfg.2_Missense_Mutation_p.A359T|PRKD2_uc002pfi.2_Missense_Mutation_p.A516T|PRKD2_uc002pfj.2_Missense_Mutation_p.A516T|PRKD2_uc010xye.1_Missense_Mutation_p.A516T|PRKD2_uc002pfk.2_Missense_Mutation_p.A359T	NM_001079881	NP_001073350	Q9BZL6	KPCD2_HUMAN	protein kinase D2 isoform A	516					cell death|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|T cell receptor signaling pathway	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein kinase C activity			ovary(2)|central_nervous_system(2)|stomach(1)|large_intestine(1)|lung(1)	7		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000189)|all cancers(93;0.000545)|Epithelial(262;0.0219)|GBM - Glioblastoma multiforme(486;0.0353)														---	---	---	---
ZC3H4	23211	broad.mit.edu	37	19	47597337	47597337	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:47597337G>A	uc002pga.3	-	4	420	c.382C>T	c.(382-384)CGC>TGC	p.R128C	ZC3H4_uc002pgb.1_RNA	NM_015168	NP_055983	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	128	Potential.						nucleic acid binding|zinc ion binding			skin(4)|ovary(2)	6		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)														---	---	---	---
GLTSCR2	29997	broad.mit.edu	37	19	48254791	48254791	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:48254791C>T	uc002phm.2	+	5	637	c.613C>T	c.(613-615)CCG>TCG	p.P205S	GLTSCR2_uc002phk.2_Missense_Mutation_p.P205S|GLTSCR2_uc002phl.2_Missense_Mutation_p.P205S|GLTSCR2_uc010elj.2_Missense_Mutation_p.P205S|GLTSCR2_uc010elk.1_RNA	NM_015710	NP_056525	Q9NZM5	GSCR2_HUMAN	glioma tumor suppressor candidate region gene 2	205				SDNPLDRPLVGQDEFFLE -> LNNPDKPVVWPGCLFPG (in Ref. 3; AAG30413).		nucleolus				central_nervous_system(1)	1		all_cancers(25;1.47e-06)|all_lung(116;6.89e-05)|all_epithelial(76;0.000108)|Lung NSC(112;0.000117)|all_neural(266;0.0332)|Ovarian(192;0.086)		all cancers(93;0.000301)|OV - Ovarian serous cystadenocarcinoma(262;0.00031)|Epithelial(262;0.0149)|GBM - Glioblastoma multiforme(486;0.0278)														---	---	---	---
PLA2G4C	8605	broad.mit.edu	37	19	48558274	48558274	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:48558274G>A	uc002phx.2	-	15	1688	c.1290C>T	c.(1288-1290)CGC>CGT	p.R430R	PLA2G4C_uc002phv.2_RNA|PLA2G4C_uc002phw.2_Silent_p.R365R|PLA2G4C_uc010elr.2_Silent_p.R430R|PLA2G4C_uc010xzd.1_Silent_p.R440R	NM_003706	NP_003697	Q9UP65	PA24C_HUMAN	phospholipase A2, group IVC isoform 1 precursor	430	PLA2c.		R -> C.		arachidonic acid metabolic process|glycerophospholipid catabolic process|inflammatory response|intracellular signal transduction|parturition	cytosol|membrane	calcium-independent phospholipase A2 activity|phospholipid binding			ovary(1)|skin(1)	2		all_cancers(25;2.84e-05)|all_lung(116;4.62e-05)|Lung NSC(112;7.61e-05)|all_epithelial(76;0.000192)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;8.09e-05)|all cancers(93;0.000517)|Epithelial(262;0.0135)|GBM - Glioblastoma multiforme(486;0.0717)														---	---	---	---
LIG1	3978	broad.mit.edu	37	19	48654587	48654587	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:48654587G>T	uc002pia.1	-	7	596	c.476C>A	c.(475-477)ACC>AAC	p.T159N	LIG1_uc010xze.1_5'UTR|LIG1_uc002phz.1_RNA|LIG1_uc002pib.1_RNA|LIG1_uc010xzf.1_Intron|LIG1_uc010xzg.1_Missense_Mutation_p.T128N|LIG1_uc010xzh.1_RNA	NM_000234	NP_000225	P18858	DNLI1_HUMAN	DNA ligase I	159					anatomical structure morphogenesis|base-excision repair|cell division|DNA ligation involved in DNA repair|DNA strand elongation involved in DNA replication|double-strand break repair via homologous recombination|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding			large_intestine(2)|lung(1)	3		all_epithelial(76;3.1e-06)|all_lung(116;4.39e-06)|Lung NSC(112;8.96e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;8.45e-05)|all cancers(93;0.000423)|Epithelial(262;0.0177)|GBM - Glioblastoma multiforme(486;0.0329)	Bleomycin(DB00290)								NER					---	---	---	---
RPL18	6141	broad.mit.edu	37	19	49118710	49118710	+	Intron	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49118710G>T	uc002pjq.1	-						FAM83E_uc002pjn.2_5'Flank|RPL18_uc002pjp.1_Intron	NM_000979	NP_000970			ribosomal protein L18						endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	RNA binding|structural constituent of ribosome				0		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.89e-05)|all cancers(93;0.00011)|GBM - Glioblastoma multiforme(486;0.0061)|Epithelial(262;0.0154)														---	---	---	---
GYS1	2997	broad.mit.edu	37	19	49494706	49494706	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49494706C>T	uc002plp.2	-	2	394	c.153G>A	c.(151-153)GCG>GCA	p.A51A	GYS1_uc010xzy.1_Intron|GYS1_uc010emm.2_Silent_p.A51A|GYS1_uc010xzz.1_Intron|GYS1_uc010yaa.1_Intron|RUVBL2_uc002plq.1_5'Flank|RUVBL2_uc010yab.1_5'Flank|RUVBL2_uc002plr.1_5'Flank|RUVBL2_uc002pls.1_5'Flank|RUVBL2_uc010emn.1_5'Flank	NM_002103	NP_002094	P13807	GYS1_HUMAN	glycogen synthase 1 (muscle) isoform 1	51					glucose metabolic process|glycogen biosynthetic process	cytosol	glycogen (starch) synthase activity|protein binding			ovary(2)	2		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000164)|all cancers(93;0.000226)|GBM - Glioblastoma multiforme(486;0.00561)|Epithelial(262;0.0286)														---	---	---	---
RUVBL2	10856	broad.mit.edu	37	19	49510289	49510289	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49510289C>A	uc002plr.1	+	5	293	c.280C>A	c.(280-282)CTG>ATG	p.L94M	RUVBL2_uc002plq.1_Missense_Mutation_p.L49M|RUVBL2_uc010yab.1_Missense_Mutation_p.L94M|RUVBL2_uc002pls.1_RNA|RUVBL2_uc010emn.1_Missense_Mutation_p.L49M|RUVBL2_uc010yac.1_Missense_Mutation_p.L49M	NM_006666	NP_006657	Q9Y230	RUVB2_HUMAN	RuvB-like 2	94					cellular response to UV|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|protein folding|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex|membrane|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|ATP-dependent DNA helicase activity|damaged DNA binding|identical protein binding|unfolded protein binding				0		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000449)|OV - Ovarian serous cystadenocarcinoma(262;0.000555)|GBM - Glioblastoma multiforme(486;0.00585)|Epithelial(262;0.047)														---	---	---	---
DKKL1	27120	broad.mit.edu	37	19	49878158	49878158	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49878158G>A	uc002pnk.2	+	5	816	c.602G>A	c.(601-603)CGG>CAG	p.R201Q		NM_014419	NP_055234	Q9UK85	DKKL1_HUMAN	dickkopf-like 1 precursor	201					anatomical structure morphogenesis	extracellular space	protein binding|signal transducer activity				0		all_lung(116;1.66e-06)|Lung NSC(112;5.89e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0456)														---	---	---	---
LRRC4B	94030	broad.mit.edu	37	19	51021955	51021955	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:51021955G>A	uc002pss.2	-	3	1152	c.1015C>T	c.(1015-1017)CGC>TGC	p.R339C		NM_001080457	NP_001073926	Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B precursor	339	LRRCT.|Extracellular (Potential).					cell junction|integral to membrane|presynaptic membrane				central_nervous_system(1)|skin(1)	2		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)														---	---	---	---
SIGLEC9	27180	broad.mit.edu	37	19	51628989	51628989	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:51628989C>T	uc002pvu.2	+	2	624	c.557C>T	c.(556-558)TCC>TTC	p.S186F	SIGLEC9_uc010yct.1_Missense_Mutation_p.S186F	NM_014441	NP_055256	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9 precursor	186	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)														---	---	---	---
SIGLEC6	946	broad.mit.edu	37	19	52033142	52033142	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:52033142T>C	uc002pwy.2	-	5	1010	c.848A>G	c.(847-849)CAC>CGC	p.H283R	SIGLEC6_uc002pwz.2_Missense_Mutation_p.H267R|SIGLEC6_uc002pxa.2_Missense_Mutation_p.H283R|SIGLEC6_uc010ydb.1_Missense_Mutation_p.H220R|SIGLEC6_uc010ydc.1_Missense_Mutation_p.H283R|SIGLEC6_uc010eoz.1_Missense_Mutation_p.H261R|SIGLEC6_uc010epb.1_Missense_Mutation_p.H236R|SIGLEC6_uc010epa.1_Missense_Mutation_p.H272R	NM_001245	NP_001236	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6 isoform 1	283	Ig-like C2-type 2.|Extracellular (Potential).				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				ovary(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)														---	---	---	---
ZNF616	90317	broad.mit.edu	37	19	52618234	52618234	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:52618234C>T	uc002pym.2	-	4	2466	c.2183G>A	c.(2182-2184)CGG>CAG	p.R728Q	ZNF616_uc002pyn.2_RNA	NM_178523	NP_848618	Q08AN1	ZN616_HUMAN	zinc finger protein 616	728	C2H2-type 20.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)														---	---	---	---
ZNF480	147657	broad.mit.edu	37	19	52826122	52826122	+	3'UTR	SNP	T	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:52826122T>A	uc010ydl.1	+	5					ZNF480_uc002pyv.2_3'UTR|ZNF480_uc010ydm.1_3'UTR|ZNF480_uc010epn.2_3'UTR|uc002pyw.1_Intron	NM_144684	NP_653285			zinc finger protein 480						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00212)|OV - Ovarian serous cystadenocarcinoma(262;0.00369)														---	---	---	---
ZNF28	7576	broad.mit.edu	37	19	53304072	53304072	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:53304072T>C	uc002qad.2	-	4	1146	c.1026A>G	c.(1024-1026)CTA>CTG	p.L342L	ZNF28_uc002qac.2_Silent_p.L289L|ZNF28_uc010eqe.2_Silent_p.L288L	NM_006969	NP_008900	P17035	ZNF28_HUMAN	zinc finger protein 28	342	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(134;0.0386)|Lung(386;0.145)														---	---	---	---
CACNG7	59284	broad.mit.edu	37	19	54416192	54416192	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54416192T>C	uc002qcr.1	+	1	122	c.107T>C	c.(106-108)ATG>ACG	p.M36T	CACNG7_uc010era.1_Missense_Mutation_p.M36T	NM_031896	NP_114102	P62955	CCG7_HUMAN	voltage-dependent calcium channel gamma-7	36					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(1)	1	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0711)														---	---	---	---
CACNG7	59284	broad.mit.edu	37	19	54445306	54445306	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54445306C>T	uc002qcr.1	+	5	602	c.587C>T	c.(586-588)TCC>TTC	p.S196F		NM_031896	NP_114102	P62955	CCG7_HUMAN	voltage-dependent calcium channel gamma-7	196	Helical; (Potential).			GAGVMSVYLFTKRYAEEEMYRPHPAFYRPRLSDCSDYSGQF LQPEAWRRGRSPSDISSDVSIQMTQNYPPAIKYPDHLHIST SPC -> VTSVGPRL (in Ref. 1; AAK20030).	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(1)	1	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0711)														---	---	---	---
CACNG8	59283	broad.mit.edu	37	19	54466537	54466537	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54466537G>A	uc002qcs.1	+	1	244	c.138G>A	c.(136-138)ACG>ACA	p.T46T		NM_031895	NP_114101	Q8WXS5	CCG8_HUMAN	voltage-dependent calcium channel gamma-8	47					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic density|postsynaptic membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0	all_cancers(19;0.0385)|all_epithelial(19;0.0207)|all_lung(19;0.145)|Lung NSC(19;0.168)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.162)														---	---	---	---
LENG8	114823	broad.mit.edu	37	19	54967827	54967827	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54967827G>A	uc002qfv.1	+	10	1491	c.1347G>A	c.(1345-1347)GCG>GCA	p.A449A	LENG8_uc002qfw.2_Silent_p.A486A			Q96PV6	LENG8_HUMAN	RecName: Full=Leukocyte receptor cluster member 8;	449							protein binding			central_nervous_system(1)|pancreas(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.139)														---	---	---	---
KIR3DX1	90011	broad.mit.edu	37	19	55049178	55049178	+	Intron	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55049178T>C	uc010erm.2	+						KIR3DX1_uc010yfa.1_Intron|KIR3DX1_uc010yfb.1_Intron|KIR3DX1_uc010yfc.1_Intron|KIR3DX1_uc010yfd.1_Intron					Homo sapiens killer cell immunoglobulin-like receptor, three domains, X1, mRNA (cDNA clone IMAGE:4849085).											ovary(1)	1				GBM - Glioblastoma multiforme(193;0.099)														---	---	---	---
KIR2DS4	3809	broad.mit.edu	37	19	55354348	55354348	+	Silent	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55354348A>G	uc002qhm.1	+	6	736	c.690A>G	c.(688-690)TCA>TCG	p.S230S	KIR2DS4_uc010yfk.1_RNA|KIR3DL1_uc002qhl.3_Intron|KIR2DS4_uc010esg.1_Intron|KIR2DS4_uc002qhn.1_Intron	NM_012314	NP_036446	P43632	KI2S4_HUMAN	killer cell immunoglobulin-like receptor, two	230	Extracellular (Potential).					integral to plasma membrane	receptor activity				0				GBM - Glioblastoma multiforme(193;0.0192)														---	---	---	---
EPS8L1	54869	broad.mit.edu	37	19	55597494	55597494	+	Silent	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55597494C>A	uc002qis.3	+	16	1688	c.1584C>A	c.(1582-1584)CCC>CCA	p.P528P	EPS8L1_uc010ess.1_Silent_p.P542P|EPS8L1_uc010yfr.1_Silent_p.P464P|EPS8L1_uc002qiu.2_Silent_p.P401P|EPS8L1_uc002qiv.2_Silent_p.P206P|EPS8L1_uc002qiw.2_Silent_p.P307P	NM_133180	NP_573441	Q8TE68	ES8L1_HUMAN	epidermal growth factor receptor pathway	528	SH3.					cytoplasm					0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)														---	---	---	---
ZNF580	51157	broad.mit.edu	37	19	56153895	56153895	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:56153895G>A	uc002qlo.2	+	2	191	c.21G>A	c.(19-21)CGG>CGA	p.R7R	ZNF580_uc002qlm.2_Silent_p.R20R|ZNF581_uc002qln.2_Intron|ZNF580_uc002qlp.2_Silent_p.R7R|ZNF580_uc010ygd.1_Silent_p.R7R|ZNF581_uc002qlq.2_5'Flank	NM_207115	NP_996998	Q9UK33	ZN580_HUMAN	zinc finger protein 580	7	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)														---	---	---	---
NLRP8	126205	broad.mit.edu	37	19	56459621	56459621	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:56459621G>A	uc002qmh.2	+	1	424	c.353G>A	c.(352-354)CGC>CAC	p.R118H	NLRP8_uc010etg.2_Missense_Mutation_p.R118H	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	118	DAPIN.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)														---	---	---	---
ZNF71	58491	broad.mit.edu	37	19	57133281	57133281	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:57133281C>T	uc002qnm.3	+	3	864	c.626C>T	c.(625-627)ACG>ATG	p.T209M		NM_021216	NP_067039	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	209						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)														---	---	---	---
ZNF749	388567	broad.mit.edu	37	19	57955692	57955692	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:57955692T>C	uc002qoq.2	+	3	1430	c.1176T>C	c.(1174-1176)AGT>AGC	p.S392S	ZNF547_uc002qpm.3_Intron	NM_001023561	NP_001018855	O43361	ZN749_HUMAN	zinc finger protein 749	392	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)|Lung(386;0.177)														---	---	---	---
ZNF551	90233	broad.mit.edu	37	19	58199066	58199066	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58199066T>C	uc002qpw.3	+	3	1598	c.1375T>C	c.(1375-1377)TAT>CAT	p.Y459H	ZNF551_uc002qpv.3_Missense_Mutation_p.Y402H|ZNF776_uc002qpx.2_Intron	NM_138347	NP_612356	Q7Z340	ZN551_HUMAN	zinc finger protein 551	475	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)														---	---	---	---
ZNF552	79818	broad.mit.edu	37	19	58320135	58320135	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58320135C>A	uc002qqg.2	-	3	667	c.497G>T	c.(496-498)GGG>GTG	p.G166V	ZNF587_uc002qqb.2_Intron|ZNF552_uc010yhg.1_Missense_Mutation_p.G162V	NM_024762	NP_079038	Q9H707	ZN552_HUMAN	zinc finger protein 552	166					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0259)														---	---	---	---
ZNF418	147686	broad.mit.edu	37	19	58439171	58439171	+	Silent	SNP	C	T	T	rs141826842	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58439171C>T	uc002qqs.1	-	4	670	c.378G>A	c.(376-378)CCG>CCA	p.P126P	ZNF418_uc010yhn.1_RNA|ZNF418_uc010yho.1_Silent_p.P41P	NM_133460	NP_597717	Q8TF45	ZN418_HUMAN	zinc finger protein 418	126					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)														---	---	---	---
ZSCAN1	284312	broad.mit.edu	37	19	58565294	58565294	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58565294C>A	uc002qrc.1	+	6	1349	c.1102C>A	c.(1102-1104)CAG>AAG	p.Q368K		NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	368					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)														---	---	---	---
ZNF8	7554	broad.mit.edu	37	19	58797158	58797158	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58797158A>G	uc002qry.1	+	2	272	c.142A>G	c.(142-144)ATC>GTC	p.I48V	ZNF8_uc002qrz.2_RNA	NM_021089	NP_066575	P17098	ZNF8_HUMAN	zinc finger protein 8	48	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;6.46e-05)|Lung NSC(17;0.0233)|all_neural(62;0.0381)|all_epithelial(17;0.0427)|all_lung(17;0.057)|Ovarian(87;0.17)|Colorectal(82;0.227)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.00619)														---	---	---	---
SIRPB1	10326	broad.mit.edu	37	20	1559137	1559137	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:1559137C>T	uc010gai.2	-	2	379	c.280G>A	c.(280-282)GAA>AAA	p.E94K	SIRPB1_uc002wfk.3_Missense_Mutation_p.E94K	NM_006065	NP_006056	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1 isoform 1	94	Extracellular (Potential).|Ig-like V-type.				cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding			ovary(1)	1																		---	---	---	---
TGM3	7053	broad.mit.edu	37	20	2308960	2308960	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:2308960G>C	uc002wfx.3	+	9	1379	c.1282G>C	c.(1282-1284)GTG>CTG	p.V428L		NM_003245	NP_003236	Q08188	TGM3_HUMAN	transglutaminase 3 precursor	428					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(4)|ovary(3)|breast(1)|skin(1)	9					L-Glutamine(DB00130)													---	---	---	---
CPXM1	56265	broad.mit.edu	37	20	2777036	2777036	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:2777036G>A	uc002wgu.2	-	9	1163	c.1099C>T	c.(1099-1101)CGG>TGG	p.R367W	CPXM1_uc010gas.2_Missense_Mutation_p.R367W	NM_019609	NP_062555	Q96SM3	CPXM1_HUMAN	carboxypeptidase X, member 1 precursor	367					cell adhesion|proteolysis		metallocarboxypeptidase activity|zinc ion binding			ovary(2)|skin(2)	4																		---	---	---	---
SLC4A11	83959	broad.mit.edu	37	20	3212106	3212106	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:3212106C>T	uc002wig.2	-	7	914	c.866G>A	c.(865-867)CGC>CAC	p.R289H	SLC4A11_uc010zqe.1_Missense_Mutation_p.R316H|SLC4A11_uc002wih.2_RNA|SLC4A11_uc010zqf.1_Missense_Mutation_p.R273H	NM_032034	NP_114423	Q8NBS3	S4A11_HUMAN	solute carrier family 4 member 11	289	Cytoplasmic (Potential).				cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			ovary(1)	1																		---	---	---	---
C20orf194	25943	broad.mit.edu	37	20	3329232	3329232	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:3329232G>A	uc002wii.2	-	8	780	c.729C>T	c.(727-729)TTC>TTT	p.F243F	C20orf194_uc002wik.2_5'UTR|C20orf194_uc010gay.1_RNA	NM_001009984	NP_001009984	Q5TEA3	CT194_HUMAN	hypothetical protein LOC25943	243											0																		---	---	---	---
CDC25B	994	broad.mit.edu	37	20	3782594	3782594	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:3782594C>A	uc002wjn.2	+	10	1723	c.945C>A	c.(943-945)TGC>TGA	p.C315*	CDC25B_uc010zqk.1_Nonsense_Mutation_p.C251*|CDC25B_uc010zql.1_Nonsense_Mutation_p.C237*|CDC25B_uc010zqm.1_Nonsense_Mutation_p.C224*|CDC25B_uc002wjl.2_Nonsense_Mutation_p.C203*|CDC25B_uc002wjm.2_Nonsense_Mutation_p.C203*|CDC25B_uc002wjo.2_Nonsense_Mutation_p.C301*|CDC25B_uc002wjp.2_Nonsense_Mutation_p.C274*|CDC25B_uc002wjq.2_Nonsense_Mutation_p.C115*|CDC25B_uc010gbc.2_5'Flank	NM_021873	NP_068659	P30305	MPIP2_HUMAN	cell division cycle 25B isoform 1	315					cell division|G2/M transition of mitotic cell cycle|mitosis|positive regulation of cell proliferation	cytosol|microtubule organizing center|nucleoplasm	protein binding|protein tyrosine phosphatase activity			lung(3)|ovary(2)	5																		---	---	---	---
CHGB	1114	broad.mit.edu	37	20	5903916	5903916	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:5903916C>T	uc002wmg.2	+	4	1432	c.1126C>T	c.(1126-1128)CAG>TAG	p.Q376*	CHGB_uc010zqz.1_Nonsense_Mutation_p.Q59*	NM_001819	NP_001810	P05060	SCG1_HUMAN	chromogranin B precursor	376						extracellular region	hormone activity			breast(3)|skin(2)|ovary(1)	6																		---	---	---	---
MCM8	84515	broad.mit.edu	37	20	5963607	5963607	+	Intron	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:5963607C>T	uc002wmi.2	+						MCM8_uc002wmj.2_Intron|MCM8_uc002wmk.2_Intron|MCM8_uc002wml.2_Intron|MCM8_uc010gbp.2_Intron|MCM8_uc002wmm.2_Intron	NM_032485	NP_115874			minichromosome maintenance complex component 8						cell cycle checkpoint|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|nucleoside-triphosphatase activity			skin(1)	1																		---	---	---	---
PLCB1	23236	broad.mit.edu	37	20	8755367	8755367	+	Splice_Site	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:8755367G>A	uc002wnb.2	+	27	3114	c.3111_splice	c.e27+1	p.L1037_splice	PLCB1_uc010zrb.1_Splice_Site_p.L936_splice|PLCB1_uc002wna.2_Splice_Site_p.L1037_splice|PLCB1_uc002wnc.1_Splice_Site_p.L936_splice|PLCB1_uc002wnd.1_Splice_Site_p.L614_splice	NM_015192	NP_056007			phosphoinositide-specific phospholipase C beta 1						activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12																		---	---	---	---
ISM1	140862	broad.mit.edu	37	20	13279916	13279916	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:13279916C>T	uc010gce.1	+	6	1211	c.1205C>T	c.(1204-1206)ACG>ATG	p.T402M	TASP1_uc010zri.1_Intron	NM_080826	NP_543016	B1AKI9	ISM1_HUMAN	isthmin 1 homolog precursor	402	AMOP.					extracellular region					0																		---	---	---	---
MACROD2	140733	broad.mit.edu	37	20	15948247	15948247	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:15948247T>C	uc002wou.2	+	13	1221	c.957T>C	c.(955-957)CAT>CAC	p.H319H	MACROD2_uc002wot.2_Silent_p.H319H|MACROD2_uc002woz.2_Silent_p.H84H|MACROD2_uc002wpb.2_Silent_p.H84H	NM_080676	NP_542407	A1Z1Q3	MACD2_HUMAN	MACRO domain containing 2 isoform 1	319	Glu-rich.										0		all_neural(2;0.0381)|Acute lymphoblastic leukemia(2;0.175)																---	---	---	---
CSRP2BP	57325	broad.mit.edu	37	20	18143418	18143418	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:18143418G>A	uc002wqj.2	+	7	2122	c.1500G>A	c.(1498-1500)GCG>GCA	p.A500A	CSRP2BP_uc002wqk.2_Silent_p.A372A|CSRP2BP_uc010zru.1_Silent_p.A371A	NM_020536	NP_065397	Q9H8E8	CSR2B_HUMAN	CSRP2 binding protein	500					histone H3 acetylation	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm	LIM domain binding|N-acetyltransferase activity			lung(3)|ovary(2)|skin(1)	6																		---	---	---	---
GZF1	64412	broad.mit.edu	37	20	23346237	23346237	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:23346237G>A	uc010gdb.2	+	3	1391	c.1217G>A	c.(1216-1218)CGG>CAG	p.R406Q	GZF1_uc002wsy.2_Missense_Mutation_p.R406Q|GZF1_uc010zsq.1_Intron|GZF1_uc010zsr.1_Intron|GZF1_uc002wsz.2_Missense_Mutation_p.R406Q	NM_022482	NP_071927	Q9H116	GZF1_HUMAN	GDNF-inducible zinc finger protein 1	406					transcription, DNA-dependent	nucleolus|nucleoplasm	sequence-specific DNA binding|zinc ion binding			kidney(1)	1	Lung NSC(19;0.0605)|Colorectal(13;0.0993)|all_lung(19;0.135)																	---	---	---	---
ABHD12	26090	broad.mit.edu	37	20	25300924	25300924	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:25300924G>A	uc002wus.1	-	4	591	c.453C>T	c.(451-453)AAC>AAT	p.N151N	ABHD12_uc002wuq.2_Silent_p.N151N|ABHD12_uc002wur.2_Silent_p.N151N|ABHD12_uc002wut.1_Silent_p.N151N|ABHD12_uc002wuu.1_Intron	NM_001042472	NP_001035937	Q8N2K0	ABD12_HUMAN	abhydrolase domain containing 12 isoform a	151	Extracellular (Potential).					integral to membrane	acylglycerol lipase activity			skin(1)	1																		---	---	---	---
NINL	22981	broad.mit.edu	37	20	25456719	25456719	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:25456719G>A	uc002wux.1	-	17	3282	c.3208C>T	c.(3208-3210)CGG>TGG	p.R1070W	NINL_uc010gdn.1_Intron	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	1070	Potential.				G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5																		---	---	---	---
FOXS1	2307	broad.mit.edu	37	20	30432967	30432967	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:30432967C>T	uc002wwt.1	-	1	454	c.379G>A	c.(379-381)GCC>ACC	p.A127T		NM_004118	NP_004109	O43638	FOXS1_HUMAN	forkhead box S1	127					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|insulin receptor signaling pathway|lymphangiogenesis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|neural crest cell fate commitment|neuromuscular process controlling balance|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of multicellular organism growth|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|somitogenesis|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(1)	1																		---	---	---	---
DNMT3B	1789	broad.mit.edu	37	20	31387046	31387046	+	Intron	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:31387046G>A	uc002wyc.2	+						DNMT3B_uc010zty.1_Intron|DNMT3B_uc002wyd.2_Intron|DNMT3B_uc002wye.2_Intron|DNMT3B_uc010gee.2_Intron|DNMT3B_uc010gef.2_Intron|DNMT3B_uc010ztz.1_Intron|DNMT3B_uc010zua.1_Intron|DNMT3B_uc002wyf.2_Intron|DNMT3B_uc002wyg.2_Intron|DNMT3B_uc010geg.2_5'Flank|DNMT3B_uc010geh.2_5'Flank	NM_006892	NP_008823			DNA cytosine-5 methyltransferase 3 beta isoform						negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			lung(3)|ovary(2)	5																		---	---	---	---
C20orf186	149954	broad.mit.edu	37	20	31671314	31671314	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:31671314G>A	uc010zue.1	+	3	326	c.311G>A	c.(310-312)CGA>CAA	p.R104Q		NM_182519	NP_872325	P59827	LPLC4_HUMAN	antimicrobial peptide RY2G5 precursor	104						cytoplasm|extracellular region	lipid binding				0																		---	---	---	---
EIF2S2	8894	broad.mit.edu	37	20	32693170	32693170	+	Intron	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:32693170G>A	uc002xaf.2	-						EIF2S2_uc002xag.2_Intron|EIF2S2_uc010ges.2_Intron	NM_003908	NP_003899			eukaryotic translation initiation factor 2 beta							cytosol|eukaryotic translation initiation factor 2 complex	metal ion binding|protein binding|translation initiation factor activity			large_intestine(1)	1																		---	---	---	---
NCOA6	23054	broad.mit.edu	37	20	33330511	33330511	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:33330511T>C	uc002xav.2	-	12	6120	c.3549A>G	c.(3547-3549)CAA>CAG	p.Q1183Q	NCOA6_uc002xaw.2_Silent_p.Q1183Q	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	1183	NCOA1-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7																		---	---	---	---
C20orf152	140894	broad.mit.edu	37	20	34572710	34572710	+	Intron	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:34572710C>T	uc002xes.1	+						C20orf152_uc002xer.1_Intron|C20orf152_uc010gfp.1_Intron					SubName: Full=C20orf152 protein;												0	Breast(12;0.00631)																	---	---	---	---
C20orf132	140699	broad.mit.edu	37	20	35783525	35783525	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:35783525G>A	uc010zvu.1	-	11	1136	c.1045C>T	c.(1045-1047)CGG>TGG	p.R349W	C20orf132_uc002xgk.2_Intron|C20orf132_uc002xgm.2_Missense_Mutation_p.R349W|C20orf132_uc002xgn.2_Intron	NM_152503	NP_689716	Q9H579	CT132_HUMAN	hypothetical protein LOC140699 isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment											0		Myeloproliferative disorder(115;0.00878)																---	---	---	---
BPI	671	broad.mit.edu	37	20	36937464	36937464	+	Intron	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:36937464C>T	uc002xib.2	+							NM_001725	NP_001716			bactericidal/permeability-increasing protein						defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			ovary(4)	4		Myeloproliferative disorder(115;0.00878)																---	---	---	---
CHD6	84181	broad.mit.edu	37	20	40122502	40122502	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:40122502C>A	uc002xka.1	-	9	1353	c.1175G>T	c.(1174-1176)GGG>GTG	p.G392V	CHD6_uc002xkd.2_Missense_Mutation_p.G370V	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	392	Chromo 2.				chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)																---	---	---	---
CHD6	84181	broad.mit.edu	37	20	40143482	40143482	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:40143482G>A	uc002xka.1	-	4	842	c.664C>T	c.(664-666)CGG>TGG	p.R222W	CHD6_uc002xkd.2_Missense_Mutation_p.R200W|CHD6_uc002xkc.2_Missense_Mutation_p.R257W	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	222					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)																---	---	---	---
PTPRT	11122	broad.mit.edu	37	20	41408874	41408874	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:41408874G>A	uc002xkg.2	-	4	736	c.552C>T	c.(550-552)GTC>GTT	p.V184V	PTPRT_uc010ggj.2_Silent_p.V184V	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	184	Extracellular (Potential).|MAM.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)																---	---	---	---
STK4	6789	broad.mit.edu	37	20	43703810	43703810	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:43703810A>C	uc002xnb.2	+	11	1547	c.1457A>C	c.(1456-1458)AAC>ACC	p.N486T	STK4_uc010ggx.2_3'UTR|STK4_uc010ggy.2_Missense_Mutation_p.N431T	NM_006282	NP_006273	Q13043	STK4_HUMAN	serine/threonine kinase 4	486					apoptosis|cell morphogenesis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of apoptosis|protein autophosphorylation	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein homodimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity|transcription factor binding			ovary(1)|skin(1)	2		Myeloproliferative disorder(115;0.0122)																---	---	---	---
PLTP	5360	broad.mit.edu	37	20	44536399	44536399	+	Intron	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:44536399G>A	uc002xqn.1	-						PLTP_uc002xql.1_Intron|PLTP_uc002xqm.1_Intron|PLTP_uc002xqo.1_Intron|PLTP_uc002xqp.1_Intron|PLTP_uc002xqq.1_Intron|PLTP_uc010zxj.1_Intron|PLTP_uc010ghj.1_Intron	NM_006227	NP_006218			phospholipid transfer protein isoform a						cellular lipid metabolic process|lipid transport	extracellular region	lipid binding			ovary(1)	1		Myeloproliferative disorder(115;0.0122)																---	---	---	---
ELMO2	63916	broad.mit.edu	37	20	45016086	45016086	+	Intron	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:45016086G>A	uc002xrt.1	-						ELMO2_uc002xru.1_Intron|ELMO2_uc010zxr.1_Intron|ELMO2_uc010zxs.1_Intron|ELMO2_uc002xrw.2_5'Flank|ELMO2_uc002xrx.1_Intron	NM_133171	NP_573403			engulfment and cell motility 2						apoptosis|cell chemotaxis|phagocytosis	cytoskeleton|cytosol|membrane	lyase activity|receptor tyrosine kinase binding|SH3 domain binding			ovary(1)	1		Myeloproliferative disorder(115;0.0122)																---	---	---	---
SLC13A3	64849	broad.mit.edu	37	20	45242172	45242172	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:45242172C>T	uc002xsf.1	-	2	342	c.304G>A	c.(304-306)GCC>ACC	p.A102T	SLC13A3_uc010ghn.1_Missense_Mutation_p.A71T|SLC13A3_uc010zxw.1_Missense_Mutation_p.A102T|SLC13A3_uc002xsg.1_Missense_Mutation_p.A55T|SLC13A3_uc010gho.1_Missense_Mutation_p.A55T|SLC13A3_uc010zxx.1_Missense_Mutation_p.A4T|SLC13A3_uc002xsi.3_Missense_Mutation_p.A55T	NM_022829	NP_073740	Q8WWT9	S13A3_HUMAN	solute carrier family 13 member 3 isoform a	102	Helical; (Potential).					integral to membrane|plasma membrane	high affinity sodium:dicarboxylate symporter activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)			Succinic acid(DB00139)													---	---	---	---
ZNFX1	57169	broad.mit.edu	37	20	47865238	47865238	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:47865238G>A	uc002xui.2	-	14	4570	c.4323C>T	c.(4321-4323)TGC>TGT	p.C1441C		NM_021035	NP_066363	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	1441	NF-X1-type 4.						metal ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)															---	---	---	---
ADNP	23394	broad.mit.edu	37	20	49508350	49508350	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:49508350G>A	uc002xvt.1	-	5	3246	c.2901C>T	c.(2899-2901)GAC>GAT	p.D967D	ADNP_uc002xvu.1_Silent_p.D967D	NM_015339	NP_056154	Q9H2P0	ADNP_HUMAN	activity-dependent neuroprotector	967						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2																		---	---	---	---
KCNG1	3755	broad.mit.edu	37	20	49620572	49620572	+	3'UTR	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:49620572G>A	uc002xwa.3	-	3						NM_002237	NP_002228			potassium voltage-gated channel, subfamily G,							voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
ATP9A	10079	broad.mit.edu	37	20	50245609	50245609	+	Silent	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:50245609A>G	uc002xwg.1	-	16	1671	c.1671T>C	c.(1669-1671)GAT>GAC	p.D557D	ATP9A_uc010gih.1_Silent_p.D421D|ATP9A_uc002xwf.1_Intron	NM_006045	NP_006036	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	557	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(4)	4																		---	---	---	---
ZFP64	55734	broad.mit.edu	37	20	50768713	50768713	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:50768713A>T	uc002xwl.2	-	6	2367	c.2018T>A	c.(2017-2019)CTC>CAC	p.L673H	ZFP64_uc002xwk.2_Intron|ZFP64_uc002xwm.2_Missense_Mutation_p.L671H|ZFP64_uc002xwn.2_Missense_Mutation_p.L619H	NM_018197	NP_060667	Q9NPA5	ZF64A_HUMAN	zinc finger protein 64 isoform a	673					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2																		---	---	---	---
CSTF1	1477	broad.mit.edu	37	20	54972482	54972482	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:54972482C>T	uc002xxl.1	+	3	589	c.389C>T	c.(388-390)GCT>GTT	p.A130V	CSTF1_uc002xxm.1_Missense_Mutation_p.A130V|CSTF1_uc002xxn.1_Missense_Mutation_p.A130V|CSTF1_uc002xxo.1_Missense_Mutation_p.A73V	NM_001033521	NP_001028693	Q05048	CSTF1_HUMAN	cleavage stimulation factor subunit 1	130	WD 1.				mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	protein binding|RNA binding			central_nervous_system(1)	1			Colorectal(105;0.202)															---	---	---	---
Unknown	0	broad.mit.edu	37	20	56064036	56064036	+	Silent	SNP	A	G	G	rs6015012	byFrequency;by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:56064036A>G	uc010zzl.1	-	1	48	c.48T>C	c.(46-48)TAT>TAC	p.Y16Y	CTCFL_uc010giu.2_RNA|CTCFL_uc010giv.2_RNA	NM_001008735	NP_001008735			high-mobility group box 1-like 1																														---	---	---	---
GNAS	2778	broad.mit.edu	37	20	57485424	57485424	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:57485424C>T	uc002xzw.2	+	12	3220	c.2935C>T	c.(2935-2937)CGG>TGG	p.R979W	GNAS_uc002xzt.2_3'UTR|GNAS_uc010gjq.2_Missense_Mutation_p.R277W|GNAS_uc002xzx.2_Missense_Mutation_p.R277W|GNAS_uc010gjr.2_Missense_Mutation_p.R227W|GNAS_uc002xzy.2_Missense_Mutation_p.R262W|GNAS_uc002yaa.2_Missense_Mutation_p.R322W|GNAS_uc010zzt.1_Missense_Mutation_p.R337W|GNAS_uc002yab.2_Intron|GNAS_uc002yad.2_Missense_Mutation_p.R227W|GNAS_uc002yae.2_Missense_Mutation_p.R261W	NM_080425	NP_536350	P63092	GNAS2_HUMAN	GNAS complex locus XLas	336					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			pituitary(201)|thyroid(35)|ovary(15)|adrenal_gland(9)|liver(7)|large_intestine(5)|parathyroid(5)|kidney(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|testis(1)|stomach(1)|small_intestine(1)|autonomic_ganglia(1)|pancreas(1)	292	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)					Mis		pituitary adenoma		McCune-Albright syndrome; pseudohypoparathyroidism|type IA		3-Methylglutaconic_Aciduria_and_Myelodysplasia|McCune-Albright_syndrome|Mazabraud_syndrome	TSP Lung(22;0.16)			---	---	---	---
ZNF831	128611	broad.mit.edu	37	20	57766113	57766113	+	Silent	SNP	G	A	A	rs148289392	by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:57766113G>A	uc002yan.2	+	1	39	c.39G>A	c.(37-39)GCG>GCA	p.A13A		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	13	Pro-rich.					intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)																	---	---	---	---
PPP1R3D	5509	broad.mit.edu	37	20	58514315	58514315	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:58514315G>A	uc002ybb.2	-	1	1038	c.672C>T	c.(670-672)CGC>CGT	p.R224R	C20orf177_uc002yba.2_Intron|C20orf177_uc010zzx.1_5'Flank|C20orf177_uc002ybc.2_5'Flank	NM_006242	NP_006233	O95685	PPR3D_HUMAN	protein phosphatase 1, regulatory subunit 3D	224	CBM21.				glycogen metabolic process		protein binding|protein serine/threonine phosphatase activity				0	all_lung(29;0.00391)		BRCA - Breast invasive adenocarcinoma(7;5.12e-09)															---	---	---	---
CDH4	1002	broad.mit.edu	37	20	60499487	60499487	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:60499487A>G	uc002ybn.1	+	11	1738	c.1724A>G	c.(1723-1725)TAC>TGC	p.Y575C	CDH4_uc002ybp.1_Missense_Mutation_p.Y501C	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	575	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)															---	---	---	---
HRH3	11255	broad.mit.edu	37	20	60791877	60791877	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:60791877C>T	uc002ycf.2	-	3	820	c.523G>A	c.(523-525)GAG>AAG	p.E175K	HRH3_uc002ycg.2_Missense_Mutation_p.E175K|HRH3_uc002ych.2_Missense_Mutation_p.E175K|HRH3_uc002yci.2_Missense_Mutation_p.E175K	NM_007232	NP_009163	Q9Y5N1	HRH3_HUMAN	histamine receptor H3	175	Helical; Name=4; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|neurotransmitter secretion	integral to plasma membrane	histamine receptor activity				0	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;7.08e-07)		Histamine Phosphate(DB00667)													---	---	---	---
YTHDF1	54915	broad.mit.edu	37	20	61833652	61833652	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:61833652T>A	uc002yeh.2	-	4	1934	c.1640A>T	c.(1639-1641)GAG>GTG	p.E547V	YTHDF1_uc011aaq.1_Missense_Mutation_p.E497V	NM_017798	NP_060268	Q9BYJ9	YTHD1_HUMAN	YTH domain family, member 1	547										ovary(2)	2																		---	---	---	---
YTHDF1	54915	broad.mit.edu	37	20	61845261	61845261	+	Silent	SNP	A	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:61845261A>C	uc002yeh.2	-	3	381	c.87T>G	c.(85-87)GTT>GTG	p.V29V		NM_017798	NP_060268	Q9BYJ9	YTHD1_HUMAN	YTH domain family, member 1	29										ovary(2)	2																		---	---	---	---
CHRNA4	1137	broad.mit.edu	37	20	61981128	61981128	+	Silent	SNP	C	T	T	rs121912283		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:61981128C>T	uc002yes.2	-	5	1813	c.1635G>A	c.(1633-1635)ACG>ACA	p.T545T	CHRNA4_uc002yet.1_Silent_p.T369T|CHRNA4_uc011aaw.1_RNA|CHRNA4_uc010gke.1_Silent_p.T474T|CHRNA4_uc002yev.1_Silent_p.T369T|CHRNA4_uc010gkf.1_Silent_p.T369T	NM_000744	NP_000735	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 subunit	545	Cytoplasmic (Potential).				B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)													---	---	---	---
GMEB2	26205	broad.mit.edu	37	20	62223462	62223462	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:62223462C>A	uc002yfp.1	-	8	1344	c.865G>T	c.(865-867)GGC>TGC	p.G289C	GMEB2_uc002yfo.1_Missense_Mutation_p.G211C|GMEB2_uc002yfq.1_Missense_Mutation_p.G289C	NM_012384	NP_036516	Q9UKD1	GMEB2_HUMAN	glucocorticoid modulatory element binding	289					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|metal ion binding				0	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;4.79e-09)|all cancers(9;2.76e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(5;0.0114)															---	---	---	---
RTEL1	51750	broad.mit.edu	37	20	62298912	62298912	+	Intron	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:62298912G>T	uc002yfu.1	+						RTEL1_uc011abc.1_Intron|RTEL1_uc002yft.1_Intron|RTEL1_uc011abd.1_Intron|RTEL1_uc002yfv.2_Intron|RTEL1_uc011abe.1_Intron|RTEL1_uc002yfw.2_Intron	NM_016434	NP_057518			regulator of telomere elongation helicase 1						DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding				0	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)															---	---	---	---
ZBTB46	140685	broad.mit.edu	37	20	62407140	62407140	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:62407140G>A	uc002ygv.1	-	3	1314	c.1113C>T	c.(1111-1113)CGC>CGT	p.R371R	ZBTB46_uc002ygu.2_RNA	NM_025224	NP_079500	Q86UZ6	ZBT46_HUMAN	zinc finger and BTB domain containing 46	371					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)|ovary(1)	2	all_cancers(38;2.09e-12)|all_epithelial(29;3.8e-14)|Lung NSC(23;7.61e-10)|all_lung(23;2.64e-09)																	---	---	---	---
ZBTB46	140685	broad.mit.edu	37	20	62421310	62421310	+	Silent	SNP	C	T	T	rs116858325	byFrequency;by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:62421310C>T	uc002ygv.1	-	2	1002	c.801G>A	c.(799-801)ACG>ACA	p.T267T	ZBTB46_uc002ygu.2_RNA	NM_025224	NP_079500	Q86UZ6	ZBT46_HUMAN	zinc finger and BTB domain containing 46	267					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)|ovary(1)	2	all_cancers(38;2.09e-12)|all_epithelial(29;3.8e-14)|Lung NSC(23;7.61e-10)|all_lung(23;2.64e-09)																	---	---	---	---
DNAJC5	80331	broad.mit.edu	37	20	62559804	62559804	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:62559804C>T	uc002yhf.2	+	2	276	c.106C>T	c.(106-108)CGG>TGG	p.R36W	DNAJC5_uc002yhg.1_Missense_Mutation_p.R36W|DNAJC5_uc002yhh.2_RNA	NM_025219	NP_079495	Q9H3Z4	DNJC5_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 5	36	J.				neurotransmitter secretion|protein folding	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|melanosome|plasma membrane	heat shock protein binding|unfolded protein binding			pancreas(1)	1	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)																	---	---	---	---
MYT1	4661	broad.mit.edu	37	20	62871228	62871228	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:62871228G>C	uc002yii.2	+	22	3573	c.3209G>C	c.(3208-3210)AGT>ACT	p.S1070T	MYT1_uc002yij.2_Missense_Mutation_p.S729T|MYT1_uc002yik.2_Missense_Mutation_p.S36T	NM_004535	NP_004526	Q01538	MYT1_HUMAN	myelin transcription factor 1	1070					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)																	---	---	---	---
RBM11	54033	broad.mit.edu	37	21	15591970	15591970	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:15591970A>C	uc002yjo.3	+	2	225	c.183A>C	c.(181-183)GAA>GAC	p.E61D	RBM11_uc002yjn.3_5'UTR|RBM11_uc002yjp.3_Intron	NM_144770	NP_658983	P57052	RBM11_HUMAN	RNA binding motif protein 11	61	RRM.						nucleotide binding|RNA binding				0				Epithelial(23;0.000314)|COAD - Colon adenocarcinoma(22;0.00242)|Colorectal(24;0.0129)|Lung(58;0.141)														---	---	---	---
NCAM2	4685	broad.mit.edu	37	21	22664432	22664432	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:22664432G>A	uc002yld.1	+	5	739	c.490G>A	c.(490-492)GCT>ACT	p.A164T	NCAM2_uc011acb.1_Missense_Mutation_p.A22T|NCAM2_uc011acc.1_Missense_Mutation_p.A189T	NM_004540	NP_004531	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2 precursor	164	Ig-like C2-type 2.|Extracellular (Potential).				neuron cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)	4		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)														---	---	---	---
ADAMTS5	11096	broad.mit.edu	37	21	28296534	28296534	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:28296534C>T	uc002ymg.2	-	8	3360	c.2631G>A	c.(2629-2631)CCG>CCA	p.P877P		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	877	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4																		---	---	---	---
RNF160	26046	broad.mit.edu	37	21	30357124	30357124	+	Missense_Mutation	SNP	C	G	G	rs16983591	byFrequency;by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:30357124C>G	uc002ymr.2	-	4	616	c.603G>C	c.(601-603)CAG>CAC	p.Q201H	RNF160_uc010gll.1_RNA	NM_015565	NP_056380	O94822	LTN1_HUMAN	zinc finger protein 294	155							ligase activity|zinc ion binding				0																		---	---	---	---
RWDD2B	10069	broad.mit.edu	37	21	30380870	30380870	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:30380870G>A	uc002yms.2	-	2	227	c.140C>T	c.(139-141)GCC>GTC	p.A47V	RWDD2B_uc002ymt.2_Missense_Mutation_p.A18V|RWDD2B_uc002ymu.2_RNA|RWDD2B_uc002ymv.2_5'UTR	NM_016940	NP_058636	P57060	RWD2B_HUMAN	RWD domain containing 2B	47	RWD.										0																		---	---	---	---
KRTAP19-1	337882	broad.mit.edu	37	21	31852411	31852411	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:31852411A>G	uc011acx.1	-	1	226	c.226T>C	c.(226-228)TGC>CGC	p.C76R		NM_181607	NP_853638	Q8IUB9	KR191_HUMAN	keratin associated protein 19-1	76	26 X 2 AA repeats of G-[YCGS].					intermediate filament					0																		---	---	---	---
SFRS15	57466	broad.mit.edu	37	21	33044468	33044468	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:33044468G>A	uc002ypd.2	-	20	3114	c.2688C>T	c.(2686-2688)GGC>GGT	p.G896G	SFRS15_uc002ype.2_Silent_p.G874G|SFRS15_uc010glu.2_Silent_p.G881G	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	896						nucleus	nucleotide binding|RNA binding				0																		---	---	---	---
TTC3	7267	broad.mit.edu	37	21	38555103	38555103	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:38555103C>T	uc002yvz.2	+	36	4750	c.4645C>T	c.(4645-4647)CTT>TTT	p.L1549F	TTC3_uc002ywa.2_Missense_Mutation_p.L1549F|TTC3_uc002ywb.2_Missense_Mutation_p.L1549F|TTC3_uc010gnf.2_Missense_Mutation_p.L1314F|TTC3_uc002ywc.2_Missense_Mutation_p.L1239F|TTC3_uc002ywd.1_Missense_Mutation_p.L613F	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1549					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)																---	---	---	---
TRAPPC10	7109	broad.mit.edu	37	21	45479047	45479047	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:45479047G>A	uc002zea.2	+	6	911	c.742G>A	c.(742-744)GAA>AAA	p.E248K	TRAPPC10_uc010gpo.2_5'UTR|TRAPPC10_uc002zdz.2_Missense_Mutation_p.E248K	NM_003274	NP_003265	P48553	TPC10_HUMAN	trafficking protein particle complex 10	248					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			ovary(1)|skin(1)	2																		---	---	---	---
PFKL	5211	broad.mit.edu	37	21	45745850	45745850	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:45745850G>A	uc002zel.2	+	20	2055	c.1996G>A	c.(1996-1998)GCT>ACT	p.A666T	PFKL_uc002zek.2_Missense_Mutation_p.A713T|PFKL_uc002zem.2_Missense_Mutation_p.A253T|PFKL_uc002zen.2_Missense_Mutation_p.A253T	NM_002626	NP_002617	P17858	K6PL_HUMAN	liver phosphofructokinase	666					fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding				0				Colorectal(79;0.0811)														---	---	---	---
POFUT2	23275	broad.mit.edu	37	21	46703299	46703299	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:46703299T>C	uc002zhc.2	-	3	551	c.526A>G	c.(526-528)AGA>GGA	p.R176G	POFUT2_uc002zhb.2_RNA|POFUT2_uc002zhd.2_Missense_Mutation_p.R176G|POFUT2_uc011afp.1_Missense_Mutation_p.R176G	NM_133635	NP_598368	Q9Y2G5	OFUT2_HUMAN	protein O-fucosyltransferase 2 isoform C	176					fucose metabolic process	endoplasmic reticulum	peptide-O-fucosyltransferase activity				0				Colorectal(79;0.243)														---	---	---	---
COL6A2	1292	broad.mit.edu	37	21	47548810	47548810	+	Intron	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:47548810G>A	uc002zia.1	+						COL6A2_uc002zhy.1_Intron|COL6A2_uc002zhz.1_Intron|COL6A2_uc002zib.1_Intron|COL6A2_uc002zic.1_Intron|COL6A2_uc010gqe.1_5'Flank	NM_001849	NP_001840			alpha 2 type VI collagen isoform 2C2 precursor						axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)														---	---	---	---
C21orf56	84221	broad.mit.edu	37	21	47581826	47581826	+	Intron	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:47581826G>A	uc011afu.1	-						C21orf56_uc002zii.2_Intron	NM_001142854	NP_001136326			hypothetical protein LOC84221 isoform 1								protein binding			skin(1)	1	Breast(49;0.214)			Colorectal(79;0.241)														---	---	---	---
PCNT	5116	broad.mit.edu	37	21	47808787	47808787	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:47808787G>A	uc002zji.3	+	18	3702	c.3595G>A	c.(3595-3597)GCC>ACC	p.A1199T	PCNT_uc002zjj.2_Missense_Mutation_p.A1081T	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	1199					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)																	---	---	---	---
PCNT	5116	broad.mit.edu	37	21	47856068	47856068	+	Intron	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:47856068A>G	uc002zji.3	+						PCNT_uc002zjj.2_Intron	NM_006031	NP_006022			pericentrin						cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)																	---	---	---	---
DIP2A	23181	broad.mit.edu	37	21	47953472	47953472	+	Silent	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:47953472C>A	uc002zjo.2	+	11	1524	c.1341C>A	c.(1339-1341)GGC>GGA	p.G447G	DIP2A_uc011afy.1_Silent_p.G383G|DIP2A_uc011afz.1_Silent_p.G443G|DIP2A_uc002zjl.2_Silent_p.G447G|DIP2A_uc002zjm.2_Silent_p.G447G|DIP2A_uc010gql.2_Silent_p.G404G|DIP2A_uc002zjn.2_Silent_p.G447G|DIP2A_uc002zjp.1_Silent_p.G192G	NM_015151	NP_055966	Q14689	DIP2A_HUMAN	disco-interacting protein 2A isoform a	447					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			ovary(2)	2	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)														---	---	---	---
MICAL3	57553	broad.mit.edu	37	22	18324702	18324702	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:18324702T>C	uc002zng.3	-	20	3040	c.2687A>G	c.(2686-2688)TAC>TGC	p.Y896C	MICAL3_uc011agl.1_Missense_Mutation_p.Y896C|MICAL3_uc002znh.2_Missense_Mutation_p.Y896C|MICAL3_uc002znj.1_Missense_Mutation_p.Y624C|MICAL3_uc002znk.1_Missense_Mutation_p.Y896C|MICAL3_uc002znl.1_Missense_Mutation_p.Y529C	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	microtubule associated monoxygenase, calponin	896	Glu-rich.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding				0		all_epithelial(15;0.198)		Lung(27;0.0427)														---	---	---	---
TUBA8	51807	broad.mit.edu	37	22	18613670	18613670	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:18613670C>T	uc002znv.1	+	5	1190	c.1117C>T	c.(1117-1119)CGG>TGG	p.R373W	TUBA8_uc002znr.2_Missense_Mutation_p.R307W|TUBA8_uc002znw.1_Missense_Mutation_p.R397W|TUBA8_uc002znx.1_Missense_Mutation_p.R220W	NM_018943	NP_061816	Q9NY65	TBA8_HUMAN	tubulin, alpha 8	373					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity				0																		---	---	---	---
GNB1L	54584	broad.mit.edu	37	22	19808240	19808240	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:19808240C>A	uc002zqe.1	-	3	529	c.135G>T	c.(133-135)CAG>CAT	p.Q45H	GNB1L_uc002zqd.1_Intron|GNB1L_uc002zqf.1_Missense_Mutation_p.Q45H	NM_053004	NP_443730	Q9BYB4	GNB1L_HUMAN	guanine nucleotide binding protein	45	WD 1.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	internal side of plasma membrane|intracellular				breast(1)	1	Colorectal(54;0.0993)																	---	---	---	---
TXNRD2	10587	broad.mit.edu	37	22	19882652	19882652	+	Intron	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:19882652C>T	uc011ahc.1	-						TXNRD2_uc002zql.1_Intron|TXNRD2_uc002zqm.1_Intron|TXNRD2_uc002zqn.1_Intron|TXNRD2_uc002zqo.1_Intron|TXNRD2_uc002zqp.1_Intron|TXNRD2_uc002zqr.1_Intron|TXNRD2_uc010grv.1_3'UTR|TXNRD2_uc002zqj.1_Intron|TXNRD2_uc002zqs.2_3'UTR	NM_006440	NP_006431			thioredoxin reductase 2 precursor						cell redox homeostasis|response to oxygen radical	mitochondrion	flavin adenine dinucleotide binding|NADP binding|thioredoxin-disulfide reductase activity			ovary(2)	2	Colorectal(54;0.0993)																	---	---	---	---
KLHL22	84861	broad.mit.edu	37	22	20819222	20819222	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:20819222C>T	uc002zsl.1	-	4	1144	c.1035G>A	c.(1033-1035)GCG>GCA	p.A345A	KLHL22_uc011ahr.1_Silent_p.A202A|KLHL22_uc002zsm.1_Silent_p.A345A	NM_032775	NP_116164	Q53GT1	KLH22_HUMAN	kelch-like	345	Kelch 1.				cell division	Cul3-RING ubiquitin ligase complex				lung(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)															---	---	---	---
PI4KA	5297	broad.mit.edu	37	22	21097019	21097019	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:21097019C>A	uc002zsz.3	-	31	3547	c.3316G>T	c.(3316-3318)GGC>TGC	p.G1106C		NM_058004	NP_477352	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase type 3 alpha	1106					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			lung(2)|upper_aerodigestive_tract(1)|salivary_gland(1)	4	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)															---	---	---	---
MAPK1	5594	broad.mit.edu	37	22	22162145	22162145	+	Intron	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:22162145G>A	uc002zvn.2	-						MAPK1_uc002zvo.2_Intron|MAPK1_uc010gtk.1_Intron	NM_002745	NP_002736			mitogen-activated protein kinase 1						activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|induction of apoptosis|innate immune response|insulin receptor signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleoplasm	ATP binding|DNA binding|MAP kinase activity|phosphatase binding|RNA polymerase II carboxy-terminal domain kinase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3	Colorectal(54;0.105)	all_lung(157;3.89e-05)		READ - Rectum adenocarcinoma(21;0.0689)	Arsenic trioxide(DB01169)													---	---	---	---
BCR	613	broad.mit.edu	37	22	23631789	23631789	+	Silent	SNP	G	A	A	rs56090728		TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:23631789G>A	uc002zww.2	+	13	3284	c.2688G>A	c.(2686-2688)CCG>CCA	p.P896P	BCR_uc002zwx.2_Silent_p.P896P|BCR_uc011aiy.1_Silent_p.P485P|BCR_uc002zwy.1_Silent_p.P182P	NM_004327	NP_004318	P11274	BCR_HUMAN	breakpoint cluster region isoform 1	896	C2.				regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	ATP binding|GTPase activator activity|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity		BCR/JAK2(6)	haematopoietic_and_lymphoid_tissue(6)|central_nervous_system(3)|urinary_tract(1)|lung(1)|skin(1)	12								T	ABL1| FGFR1|JAK2 	CML|ALL|AML						OREG0026390	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
CYTSA	23384	broad.mit.edu	37	22	24718011	24718011	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:24718011C>T	uc002zzw.2	+	5	1370	c.1063C>T	c.(1063-1065)CCC>TCC	p.P355S	CYTSA_uc002zzv.3_Missense_Mutation_p.P355S|CYTSA_uc011ajq.1_Missense_Mutation_p.P355S	NM_015330	NP_056145	Q69YQ0	CYTSA_HUMAN	cytospin A	355					cell cycle|cell division						0																		---	---	---	---
ASPHD2	57168	broad.mit.edu	37	22	26830109	26830109	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:26830109G>A	uc003acg.2	+	2	925	c.528G>A	c.(526-528)ACG>ACA	p.T176T		NM_020437	NP_065170	Q6ICH7	ASPH2_HUMAN	aspartate beta-hydroxylase domain containing 2	176	Lumenal (Potential).				peptidyl-amino acid modification	integral to endoplasmic reticulum membrane	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity			ovary(1)	1																		---	---	---	---
MN1	4330	broad.mit.edu	37	22	28193239	28193239	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:28193239G>A	uc003adj.2	-	1	4248	c.3293C>T	c.(3292-3294)GCG>GTG	p.A1098V		NM_002430	NP_002421	Q10571	MN1_HUMAN	meningioma  1	1098							binding			central_nervous_system(3)|lung(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	10								T	ETV6	AML|meningioma								---	---	---	---
GAL3ST1	9514	broad.mit.edu	37	22	30951194	30951194	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:30951194G>A	uc003aig.1	-	4	1158	c.1018C>T	c.(1018-1020)CGC>TGC	p.R340C	GAL3ST1_uc003aih.1_Missense_Mutation_p.R340C|GAL3ST1_uc003aii.1_Missense_Mutation_p.R340C|GAL3ST1_uc010gvz.1_Missense_Mutation_p.R340C	NM_004861	NP_004852	Q99999	G3ST1_HUMAN	galactose-3-O-sulfotransferase 1	340	Lumenal (Potential).				protein N-linked glycosylation	Golgi membrane|integral to plasma membrane|membrane fraction	galactosylceramide sulfotransferase activity				0																		---	---	---	---
PES1	23481	broad.mit.edu	37	22	30976107	30976107	+	Missense_Mutation	SNP	C	T	T	rs149717169	byFrequency;by1000genomes	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:30976107C>T	uc003aij.1	-	11	1176	c.1102G>A	c.(1102-1104)GTC>ATC	p.V368I	PES1_uc003aik.1_Missense_Mutation_p.V363I|PES1_uc003ail.1_Missense_Mutation_p.V351I|PES1_uc003aim.1_Missense_Mutation_p.V368I|PES1_uc003ain.1_Missense_Mutation_p.V229I|PES1_uc003aio.1_Missense_Mutation_p.V229I	NM_014303	NP_055118	O00541	PESC_HUMAN	pescadillo homolog 1, containing BRCT domain	368	Sufficient for interaction with MAP1B (By similarity).|BRCT.				cell proliferation|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of cell cycle	chromosome|nucleoplasm|PeBoW complex|preribosome, large subunit precursor	protein binding				0																		---	---	---	---
LIMK2	3985	broad.mit.edu	37	22	31672811	31672811	+	Intron	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:31672811C>T	uc003akh.2	+						LIMK2_uc003akg.2_Silent_p.C520C|LIMK2_uc003aki.2_Intron|LIMK2_uc003akj.2_Silent_p.C582C|LIMK2_uc003akk.2_Intron|LIMK2_uc011aln.1_Intron	NM_005569	NP_005560			LIM domain kinase 2 isoform 2a							mitochondrion|nucleus	ATP binding|protein serine/threonine kinase activity|zinc ion binding			ovary(2)	2																		---	---	---	---
DRG1	4733	broad.mit.edu	37	22	31822637	31822637	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:31822637T>C	uc003aku.2	+	7	881	c.750T>C	c.(748-750)ATT>ATC	p.I250I		NM_004147	NP_004138	Q9Y295	DRG1_HUMAN	developmentally regulated GTP binding protein 1	250	GTP (By similarity).				multicellular organismal development|transcription, DNA-dependent	cytoplasm|intermediate filament cytoskeleton|nucleus	GTP binding|transcription factor binding			central_nervous_system(1)	1																		---	---	---	---
SFI1	9814	broad.mit.edu	37	22	31979888	31979888	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:31979888C>T	uc003ale.2	+	13	1669	c.1276C>T	c.(1276-1278)CGG>TGG	p.R426W	SFI1_uc003ald.1_Missense_Mutation_p.R402W|SFI1_uc003alf.2_Missense_Mutation_p.R395W|SFI1_uc003alg.2_Missense_Mutation_p.R344W|SFI1_uc011alp.1_Missense_Mutation_p.R344W|SFI1_uc011alq.1_Missense_Mutation_p.R371W|SFI1_uc003alh.2_RNA|SFI1_uc010gwi.2_RNA	NM_001007467	NP_001007468	A8K8P3	SFI1_HUMAN	spindle assembly associated Sfi1 homolog isoform	426	HAT 5.				G2/M transition of mitotic cell cycle	centriole|cytosol				central_nervous_system(1)	1																		---	---	---	---
DEPDC5	9681	broad.mit.edu	37	22	32302250	32302250	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:32302250C>T	uc003als.2	+	42	4628	c.4486C>T	c.(4486-4488)CGG>TGG	p.R1496W	DEPDC5_uc011als.1_Missense_Mutation_p.R1427W|DEPDC5_uc011alu.1_Missense_Mutation_p.R1527W|DEPDC5_uc011alv.1_RNA|DEPDC5_uc003alt.2_Missense_Mutation_p.R1518W|DEPDC5_uc003alu.2_Missense_Mutation_p.R945W|DEPDC5_uc003alv.2_RNA|DEPDC5_uc003alw.2_Missense_Mutation_p.R794W|DEPDC5_uc011alx.1_Missense_Mutation_p.R344W|DEPDC5_uc010gwk.2_Missense_Mutation_p.A531V|DEPDC5_uc011aly.1_Missense_Mutation_p.R344W	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	1496					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8																		---	---	---	---
C22orf28	51493	broad.mit.edu	37	22	32797740	32797740	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:32797740T>C	uc003amm.2	-	5	622	c.491A>G	c.(490-492)AAT>AGT	p.N164S	C22orf28_uc011ama.1_Intron	NM_014306	NP_055121	Q9Y3I0	RTCB_HUMAN	hypothetical protein LOC51493	164					cell-matrix adhesion|substrate adhesion-dependent cell spreading|tRNA splicing, via endonucleolytic cleavage and ligation	cytoplasm|tRNA-splicing ligase complex	ATP binding|metal ion binding|RNA ligase (ATP) activity|vinculin binding				0																		---	---	---	---
APOL3	80833	broad.mit.edu	37	22	36537601	36537601	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:36537601C>T	uc003aot.2	-	3	894	c.856G>A	c.(856-858)GAA>AAA	p.E286K	APOL3_uc003aoq.2_Missense_Mutation_p.E215K|APOL3_uc003aor.2_Missense_Mutation_p.E215K|APOL3_uc003aos.2_Missense_Mutation_p.E215K|APOL3_uc003aou.2_Missense_Mutation_p.E86K|APOL3_uc003aov.2_Missense_Mutation_p.E86K	NM_145640	NP_663615	O95236	APOL3_HUMAN	apolipoprotein L3 isoform 1	286					inflammatory response|lipoprotein metabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|extracellular region	lipid binding|lipid transporter activity|signal transducer activity				0																		---	---	---	---
MYH9	4627	broad.mit.edu	37	22	36680441	36680441	+	Intron	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:36680441G>A	uc003apg.2	-							NM_002473	NP_002464			myosin, heavy polypeptide 9, non-muscle						actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11								T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				---	---	---	---
CSF2RB	1439	broad.mit.edu	37	22	37319309	37319309	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:37319309C>T	uc003aqa.3	+	3	317	c.100C>T	c.(100-102)CGC>TGC	p.R34C	CSF2RB_uc003aqc.3_Missense_Mutation_p.R34C	NM_000395	NP_000386	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta	34	Extracellular (Potential).				respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			skin(2)|pancreas(1)	3					Sargramostim(DB00020)													---	---	---	---
CSF2RB	1439	broad.mit.edu	37	22	37325759	37325759	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:37325759G>A	uc003aqa.3	+	6	845	c.628G>A	c.(628-630)GCC>ACC	p.A210T	CSF2RB_uc003aqc.3_Missense_Mutation_p.A210T	NM_000395	NP_000386	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta	210	Fibronectin type-III 1.|Extracellular (Potential).				respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			skin(2)|pancreas(1)	3					Sargramostim(DB00020)													---	---	---	---
MFNG	4242	broad.mit.edu	37	22	37870636	37870636	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:37870636G>A	uc003ass.1	-	6	897	c.727C>T	c.(727-729)CTG>TTG	p.L243L	MFNG_uc011ani.1_Silent_p.L121L|MFNG_uc011anj.1_Silent_p.L229L|MFNG_uc003asr.1_5'Flank	NM_002405	NP_002396	O00587	MFNG_HUMAN	O-fucosylpeptide	243	Lumenal (Potential).				pattern specification process	extracellular space|integral to Golgi membrane	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity			lung(1)	1	Melanoma(58;0.0574)																	---	---	---	---
NPTXR	23467	broad.mit.edu	37	22	39219123	39219123	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:39219123T>C	uc003awk.2	-	4	1397	c.1243A>G	c.(1243-1245)AAG>GAG	p.K415E		NM_014293	NP_055108	O95502	NPTXR_HUMAN	neuronal pentraxin receptor	415	Pentaxin.|Extracellular (Potential).					integral to membrane	metal ion binding			central_nervous_system(2)|skin(1)	3	Melanoma(58;0.04)																	---	---	---	---
PDGFB	5155	broad.mit.edu	37	22	39621845	39621845	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:39621845C>T	uc003axf.2	-	6	1598	c.609G>A	c.(607-609)ACG>ACA	p.T203T	PDGFB_uc003axe.2_Silent_p.T188T	NM_002608	NP_002599	P01127	PDGFB_HUMAN	platelet-derived growth factor beta isoform 1	203					activation of protein kinase B activity|cellular response to mycophenolic acid|embryonic placenta development|heart development|hemopoiesis|metanephric glomerular mesangial cell development|monocyte chemotaxis|negative regulation of phosphatidylinositol biosynthetic process|negative regulation of platelet activation|negative regulation of transcription, DNA-dependent|paracrine signaling|peptidyl-serine phosphorylation|peptidyl-tyrosine phosphorylation|platelet activation|platelet degranulation|positive regulation of blood vessel endothelial cell migration|positive regulation of calcium ion import|positive regulation of cell division|positive regulation of chemotaxis|positive regulation of cyclin-dependent protein kinase activity|positive regulation of DNA biosynthetic process|positive regulation of DNA replication|positive regulation of endothelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|positive regulation of glomerular filtration|positive regulation of glomerular mesangial cell proliferation|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein autophosphorylation|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription, DNA-dependent|reactive oxygen species metabolic process|transforming growth factor beta receptor signaling pathway	basolateral plasma membrane|cell surface|endoplasmic reticulum lumen|extracellular region|Golgi membrane|platelet alpha granule lumen	collagen binding|eukaryotic cell surface binding|growth factor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein heterodimerization activity|protein homodimerization activity|superoxide-generating NADPH oxidase activator activity		COL1A1/PDGFB(372)	soft_tissue(372)|central_nervous_system(1)	373	Melanoma(58;0.04)				Becaplermin(DB00102)			T	COL1A1	DFSP								---	---	---	---
PDGFB	5155	broad.mit.edu	37	22	39631786	39631786	+	Missense_Mutation	SNP	C	T	T	rs148252800	byFrequency	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:39631786C>T	uc003axf.2	-	2	1146	c.157G>A	c.(157-159)GGA>AGA	p.G53R	PDGFB_uc003axe.2_Missense_Mutation_p.G38R	NM_002608	NP_002599	P01127	PDGFB_HUMAN	platelet-derived growth factor beta isoform 1	53					activation of protein kinase B activity|cellular response to mycophenolic acid|embryonic placenta development|heart development|hemopoiesis|metanephric glomerular mesangial cell development|monocyte chemotaxis|negative regulation of phosphatidylinositol biosynthetic process|negative regulation of platelet activation|negative regulation of transcription, DNA-dependent|paracrine signaling|peptidyl-serine phosphorylation|peptidyl-tyrosine phosphorylation|platelet activation|platelet degranulation|positive regulation of blood vessel endothelial cell migration|positive regulation of calcium ion import|positive regulation of cell division|positive regulation of chemotaxis|positive regulation of cyclin-dependent protein kinase activity|positive regulation of DNA biosynthetic process|positive regulation of DNA replication|positive regulation of endothelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|positive regulation of glomerular filtration|positive regulation of glomerular mesangial cell proliferation|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein autophosphorylation|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription, DNA-dependent|reactive oxygen species metabolic process|transforming growth factor beta receptor signaling pathway	basolateral plasma membrane|cell surface|endoplasmic reticulum lumen|extracellular region|Golgi membrane|platelet alpha granule lumen	collagen binding|eukaryotic cell surface binding|growth factor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein heterodimerization activity|protein homodimerization activity|superoxide-generating NADPH oxidase activator activity		COL1A1/PDGFB(372)	soft_tissue(372)|central_nervous_system(1)	373	Melanoma(58;0.04)				Becaplermin(DB00102)			T	COL1A1	DFSP								---	---	---	---
FAM83F	113828	broad.mit.edu	37	22	40417473	40417473	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:40417473G>A	uc003ayk.1	+	4	1053	c.959G>A	c.(958-960)CGA>CAA	p.R320Q		NM_138435	NP_612444	Q8NEG4	FA83F_HUMAN	hypothetical protein LOC113828	320										breast(1)	1																		---	---	---	---
A4GALT	53947	broad.mit.edu	37	22	43088985	43088985	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:43088985G>A	uc003bdb.2	-	3	1234	c.973C>T	c.(973-975)CGG>TGG	p.R325W	A4GALT_uc010gzd.2_Missense_Mutation_p.R325W	NM_017436	NP_059132	Q9NPC4	A4GAT_HUMAN	alpha 1,4-galactosyltransferase	325	Lumenal (Potential).				glycosphingolipid biosynthetic process|plasma membrane organization	Golgi stack|integral to Golgi membrane|membrane fraction	lactosylceramide 4-alpha-galactosyltransferase activity			central_nervous_system(2)	2																		---	---	---	---
ARFGAP3	26286	broad.mit.edu	37	22	43219661	43219661	+	Splice_Site	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:43219661C>T	uc003bdd.2	-	8	892	c.672_splice	c.e8+1	p.G224_splice	ARFGAP3_uc010gzf.2_Splice_Site_p.G180_splice|ARFGAP3_uc011apu.1_Splice_Site_p.G152_splice	NM_014570	NP_055385			ADP-ribosylation factor GTPase activating						intracellular protein transport|protein secretion|regulation of ARF GTPase activity|vesicle-mediated transport	cytosol|Golgi membrane	ARF GTPase activator activity|protein transporter activity|zinc ion binding			breast(1)	1																		---	---	---	---
CELSR1	9620	broad.mit.edu	37	22	46929835	46929835	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:46929835G>A	uc003bhw.1	-	1	3233	c.3233C>T	c.(3232-3234)TCG>TTG	p.S1078L		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	1078	Extracellular (Potential).|Cadherin 8.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)														---	---	---	---
SBF1	6305	broad.mit.edu	37	22	50886875	50886875	+	Splice_Site	SNP	T	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:50886875T>G	uc003blh.2	-	38	5347	c.5152_splice	c.e38-1	p.G1718_splice	SBF1_uc003ble.2_Splice_Site_p.G182_splice|SBF1_uc003blf.2_Splice_Site_p.G194_splice|SBF1_uc011arx.1_Splice_Site_p.G1356_splice	NM_002972	NP_002963			SET binding factor 1						protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)														---	---	---	---
SHANK3	85358	broad.mit.edu	37	22	51115076	51115076	+	Silent	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:51115076C>A	uc003bne.1	+	3	294	c.294C>A	c.(292-294)GCC>GCA	p.A98A		NM_001080420	NP_001073889	F2Z3L0	F2Z3L0_HUMAN	SH3 and multiple ankyrin repeat domains 3	98										central_nervous_system(1)	1		all_cancers(38;3.75e-11)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.22)														---	---	---	---
PLCXD1	55344	broad.mit.edu	37	X	209708	209708	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:209708C>T	uc004cpc.2	+	6	868	c.556C>T	c.(556-558)CCG>TCG	p.P186S	PLCXD1_uc011mgx.1_RNA	NM_018390	NP_060860	Q9NUJ7	PLCX1_HUMAN	phosphatidylinositol-specific phospholipase C, X	186	PI-PLC X-box.				intracellular signal transduction|lipid metabolic process		phospholipase C activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)																---	---	---	---
IL3RA	3563	broad.mit.edu	37	X	1471336	1471336	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:1471336C>T	uc004cps.2	+	6	902	c.553C>T	c.(553-555)CGG>TGG	p.R185W	IL3RA_uc011mhd.1_Missense_Mutation_p.R107W	NM_002183	NP_002174	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha precursor	185	Extracellular (Potential).					integral to membrane|plasma membrane	interleukin-3 receptor activity	p.R185P(1)		skin(2)|lung(1)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)													---	---	---	---
SFRS17A	8227	broad.mit.edu	37	X	1712814	1712814	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:1712814G>A	uc004cqa.2	+	2	655	c.459G>A	c.(457-459)GGG>GGA	p.G153G	SFRS17A_uc010ncx.1_Silent_p.G153G|SFRS17A_uc004cqb.2_RNA|ASMT_uc004cqd.2_5'Flank	NM_005088	NP_005079	Q02040	AK17A_HUMAN	DNA segment on chromosome X and Y (unique) 155	153	RRM.				B cell activation|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|signal transduction	nuclear speck|spliceosomal complex	nucleotide binding|protein binding|RNA binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)																---	---	---	---
ASMT	438	broad.mit.edu	37	X	1748728	1748728	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:1748728G>A	uc004cqd.2	+	6	603	c.458G>A	c.(457-459)CGG>CAG	p.R153Q	ASMT_uc010ncy.2_Missense_Mutation_p.R153Q|ASMT_uc004cqe.2_Missense_Mutation_p.R153Q	NM_004043	NP_004034	P46597	HIOM_HUMAN	acetylserotonin O-methyltransferase	153					melatonin biosynthetic process|translation	cytosol	acetylserotonin O-methyltransferase activity|S-methyltransferase activity			skin(1)	1		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)																---	---	---	---
FRMPD4	9758	broad.mit.edu	37	X	12728602	12728602	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:12728602A>G	uc004cuz.1	+	14	2061	c.1555A>G	c.(1555-1557)AGG>GGG	p.R519G	FRMPD4_uc011mij.1_Missense_Mutation_p.R511G	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	519	FERM.				positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13																		---	---	---	---
FIGF	2277	broad.mit.edu	37	X	15402024	15402024	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:15402024G>A	uc004cwt.1	-	1	554	c.45C>T	c.(43-45)TAC>TAT	p.Y15Y		NM_004469	NP_004460	O43915	VEGFD_HUMAN	vascular endothelial growth factor D	15					angiogenesis|cell differentiation|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of cell proliferation|positive regulation of mast cell chemotaxis|vascular endothelial growth factor receptor signaling pathway	extracellular space|membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity|platelet-derived growth factor receptor binding			ovary(1)|breast(1)|central_nervous_system(1)	3	Hepatocellular(33;0.183)																	---	---	---	---
NHS	4810	broad.mit.edu	37	X	17739629	17739629	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:17739629T>C	uc004cxx.2	+	4	1259	c.921T>C	c.(919-921)AAT>AAC	p.N307N	NHS_uc011mix.1_Silent_p.N328N|NHS_uc004cxy.2_Silent_p.N151N|NHS_uc004cxz.2_Silent_p.N130N|NHS_uc004cya.2_Silent_p.N30N	NM_198270	NP_938011	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome protein isoform 1	307						nucleus				skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	Hepatocellular(33;0.183)																	---	---	---	---
GPR64	10149	broad.mit.edu	37	X	19013015	19013015	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:19013015A>T	uc004cyx.2	-	28	3032	c.2868T>A	c.(2866-2868)AAT>AAA	p.N956K	GPR64_uc004cyy.2_Missense_Mutation_p.N953K|GPR64_uc004cyz.2_Missense_Mutation_p.N942K|GPR64_uc004czb.2_Intron|GPR64_uc004czc.2_Missense_Mutation_p.N940K|GPR64_uc004czd.2_Missense_Mutation_p.N932K|GPR64_uc004cze.2_Missense_Mutation_p.N926K|GPR64_uc004czf.2_Missense_Mutation_p.N918K|GPR64_uc004cza.2_Missense_Mutation_p.N934K|GPR64_uc004cyw.2_Intron|GPR64_uc010nfj.2_Missense_Mutation_p.N837K	NM_001079858	NP_001073327	Q8IZP9	GPR64_HUMAN	G protein-coupled receptor 64 isoform 1	956	Cytoplasmic (Potential).				neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity				0	Hepatocellular(33;0.183)																	---	---	---	---
CXorf23	256643	broad.mit.edu	37	X	19983736	19983736	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:19983736T>C	uc004czp.2	-	3	700	c.700A>G	c.(700-702)AGG>GGG	p.R234G	CXorf23_uc010nfn.2_RNA|CXorf23_uc011mjg.1_5'UTR|CXorf23_uc004czo.2_Missense_Mutation_p.R184G	NM_198279	NP_938020	A2AJT9	CX023_HUMAN	hypothetical protein LOC256643	234						mitochondrion				lung(1)|skin(1)	2																		---	---	---	---
TAB3	257397	broad.mit.edu	37	X	30870901	30870901	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:30870901G>A	uc004dcj.2	-	7	2367	c.1704C>T	c.(1702-1704)ATC>ATT	p.I568I	TAB3_uc004dck.2_Silent_p.I568I|TAB3_uc010ngl.2_Silent_p.I568I	NM_152787	NP_690000	Q8N5C8	TAB3_HUMAN	mitogen-activated protein kinase kinase kinase 7	568					activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein binding|zinc ion binding			ovary(1)	1																		---	---	---	---
DUSP21	63904	broad.mit.edu	37	X	44703614	44703614	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:44703614C>T	uc004dgd.2	+	1	366	c.236C>T	c.(235-237)TCG>TTG	p.S79L		NM_022076	NP_071359	Q9H596	DUS21_HUMAN	dual specificity phosphatase 21	79	Tyrosine-protein phosphatase.|Sufficient for mitochondrial localization (By similarity).					cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			large_intestine(1)|lung(1)	2																		---	---	---	---
KDM6A	7403	broad.mit.edu	37	X	44879953	44879953	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:44879953C>T	uc004dge.3	+	6	917	c.542C>T	c.(541-543)ACA>ATA	p.T181I	KDM6A_uc010nhk.2_Missense_Mutation_p.T181I|KDM6A_uc011mkz.1_Missense_Mutation_p.T181I|KDM6A_uc011mla.1_Missense_Mutation_p.T181I|KDM6A_uc011mlb.1_Missense_Mutation_p.T181I|KDM6A_uc011mlc.1_Intron	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	181	TPR 3.				histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0(4)|p.?(1)		kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84								D|N|F|S		renal|oesophageal SCC|MM								---	---	---	---
FOXP3	50943	broad.mit.edu	37	X	49110450	49110450	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:49110450G>A	uc004dnf.3	-	9	1083	c.895C>T	c.(895-897)CGG>TGG	p.R299W	FOXP3_uc011mnb.1_Missense_Mutation_p.R322W|FOXP3_uc011mnc.1_Missense_Mutation_p.R272W|FOXP3_uc004dne.3_Missense_Mutation_p.R264W|FOXP3_uc010niq.1_Missense_Mutation_p.R264W	NM_014009	NP_054728	Q9BZS1	FOXP3_HUMAN	forkhead box P3 isoform a	299					B cell homeostasis|cerebellum development|chromatin remodeling|embryo development|myeloid cell homeostasis|negative regulation of activated T cell proliferation|negative regulation of chronic inflammatory response|negative regulation of CREB transcription factor activity|negative regulation of cytokine secretion|negative regulation of histone acetylation|negative regulation of histone deacetylation|negative regulation of interferon-gamma biosynthetic process|negative regulation of interferon-gamma production|negative regulation of interleukin-10 production|negative regulation of interleukin-2 biosynthetic process|negative regulation of interleukin-2 production|negative regulation of interleukin-4 production|negative regulation of interleukin-5 production|negative regulation of interleukin-6 production|negative regulation of isotype switching to IgE isotypes|negative regulation of NF-kappaB transcription factor activity|negative regulation of T cell cytokine production|negative regulation of tumor necrosis factor production|pattern specification process|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation|positive regulation of histone acetylation|positive regulation of immature T cell proliferation in thymus|positive regulation of peripheral T cell tolerance induction|positive regulation of T cell anergy|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transforming growth factor-beta1 production|post-embryonic development|regulation of isotype switching to IgG isotypes|response to virus|T cell homeostasis|T cell receptor signaling pathway|tolerance induction to self antigen	cytoplasm|cytoplasm|nucleus|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|histone acetyltransferase binding|histone deacetylase binding|NF-kappaB binding|NFAT protein binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription corepressor activity|zinc ion binding				0	Ovarian(276;0.236)																	---	---	---	---
MSN	4478	broad.mit.edu	37	X	64959042	64959042	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:64959042C>A	uc004dwf.2	+	12	1753	c.1555C>A	c.(1555-1557)CAG>AAG	p.Q519K		NM_002444	NP_002435	P26038	MOES_HUMAN	moesin	519					leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking	apical plasma membrane|cytoskeleton|extrinsic to membrane|microvillus membrane|nucleolus	cell adhesion molecule binding|receptor binding|structural constituent of cytoskeleton		MSN/ALK(6)	haematopoietic_and_lymphoid_tissue(6)|ovary(3)|lung(1)	10								T	ALK	ALCL								---	---	---	---
P2RY4	5030	broad.mit.edu	37	X	69478799	69478799	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:69478799G>A	uc004dxz.1	-	1	856	c.676C>T	c.(676-678)CGC>TGC	p.R226C		NM_002565	NP_002556	P51582	P2RY4_HUMAN	pyrimidinergic receptor P2Y4	226	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)	1																		---	---	---	---
MED12	9968	broad.mit.edu	37	X	70340970	70340970	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:70340970T>C	uc004dyy.2	+	5	902	c.703T>C	c.(703-705)TAC>CAC	p.Y235H	MED12_uc011mpq.1_Missense_Mutation_p.Y235H|MED12_uc004dyz.2_Missense_Mutation_p.Y235H|MED12_uc004dza.2_Missense_Mutation_p.Y82H	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	235					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)																	---	---	---	---
GPR174	84636	broad.mit.edu	37	X	78426931	78426931	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:78426931C>A	uc004edg.1	+	1	463	c.427C>A	c.(427-429)CTG>ATG	p.L143M		NM_032553	NP_115942	Q9BXC1	GP174_HUMAN	putative purinergic receptor FKSG79	143	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)|central_nervous_system(1)	2															HNSCC(63;0.18)			---	---	---	---
PCDH11X	27328	broad.mit.edu	37	X	91131771	91131771	+	Intron	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:91131771G>T	uc004efk.1	+						PCDH11X_uc004efl.1_Intron|PCDH11X_uc004efo.1_Intron|PCDH11X_uc010nmv.1_Intron|PCDH11X_uc004efm.1_Intron|PCDH11X_uc004efn.1_Intron|PCDH11X_uc004efh.1_Intron|PCDH11X_uc004efj.1_Intron	NM_032968	NP_116750			protocadherin 11 X-linked isoform c						homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2																		---	---	---	---
IRS4	8471	broad.mit.edu	37	X	107978669	107978669	+	Silent	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:107978669G>A	uc004eoc.2	-	1	939	c.906C>T	c.(904-906)ATC>ATT	p.I302I		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	302	IRS-type PTB.					plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10																		---	---	---	---
IL13RA2	3598	broad.mit.edu	37	X	114239869	114239869	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:114239869A>G	uc004epx.2	-	9	1132	c.1007T>C	c.(1006-1008)CTA>CCA	p.L336P	IL13RA2_uc010nqd.1_Missense_Mutation_p.L336P	NM_000640	NP_000631	Q14627	I13R2_HUMAN	interleukin 13 receptor, alpha 2 precursor	336	Extracellular (Potential).|Fibronectin type-III 3.					extracellular space|integral to membrane|soluble fraction	cytokine receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3																		---	---	---	---
RHOXF2B	727940	broad.mit.edu	37	X	119293252	119293252	+	Silent	SNP	C	T	T	rs142963365	byFrequency	TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:119293252C>T	uc004esl.3	+	2	601	c.411C>T	c.(409-411)AAC>AAT	p.N137N		NM_001099685	NP_001093155	P0C7M4	RHF2B_HUMAN	Rhox homeobox family, member 2B	137	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0																		---	---	---	---
GRIA3	2892	broad.mit.edu	37	X	122551612	122551612	+	Silent	SNP	A	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:122551612A>C	uc004etq.3	+	12	2153	c.1860A>C	c.(1858-1860)GGA>GGC	p.G620G	GRIA3_uc004etr.3_Silent_p.G620G|GRIA3_uc004ets.3_RNA|GRIA3_uc011muf.1_Silent_p.G604G	NM_007325	NP_015564	P42263	GRIA3_HUMAN	glutamate receptor, ionotrophic, AMPA 3 isoform	620	Cytoplasmic (Potential).				glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5					L-Glutamic Acid(DB00142)													---	---	---	---
SLC9A6	10479	broad.mit.edu	37	X	135080679	135080679	+	Silent	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:135080679C>T	uc004ezj.2	+	4	622	c.546C>T	c.(544-546)TAC>TAT	p.Y182Y	SLC9A6_uc004ezk.2_Silent_p.Y214Y|SLC9A6_uc011mvx.1_Silent_p.Y162Y	NM_006359	NP_006350	Q92581	SL9A6_HUMAN	solute carrier family 9 (sodium/hydrogen	182	Helical; (Potential).				regulation of pH	early endosome membrane|endoplasmic reticulum membrane|integral to membrane|microsome|plasma membrane|recycling endosome membrane	sodium:hydrogen antiporter activity			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
MAP7D3	79649	broad.mit.edu	37	X	135314105	135314105	+	Silent	SNP	T	C	C			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:135314105T>C	uc004ezt.2	-	8	1102	c.1011A>G	c.(1009-1011)TCA>TCG	p.S337S	MAP7D3_uc004ezs.2_Silent_p.S301S|MAP7D3_uc011mwc.1_Silent_p.S319S|MAP7D3_uc010nsa.1_Silent_p.S295S	NM_024597	NP_078873	Q8IWC1	MA7D3_HUMAN	MAP7 domain containing 3	337						cytoplasm|spindle				ovary(2)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
MAGEC1	9947	broad.mit.edu	37	X	140995606	140995606	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:140995606G>T	uc004fbt.2	+	4	2702	c.2416G>T	c.(2416-2418)GCC>TCC	p.A806S	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	806							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)														HNSCC(15;0.026)			---	---	---	---
HCFC1	3054	broad.mit.edu	37	X	153215718	153215718	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153215718C>T	uc004fjp.2	-	24	6508	c.5980G>A	c.(5980-5982)GCC>ACC	p.A1994T		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	1994					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
FUNDC2	65991	broad.mit.edu	37	X	154255299	154255299	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5726-01	TCGA-CG-5726-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:154255299G>A	uc004fmw.2	+	1	236	c.86G>A	c.(85-87)CGT>CAT	p.R29H	F8_uc011mzx.1_5'Flank	NM_023934	NP_076423	Q9BWH2	FUND2_HUMAN	FUN14 domain containing 2	29						mitochondrion					0	all_cancers(53;3.51e-17)|all_epithelial(53;5.13e-11)|all_lung(58;3.84e-07)|Lung NSC(58;1.2e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)																	---	---	---	---
