Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_status	validation_method	validation_tumor_sample	validation_alt_allele
HNRNPR	10236	broad.mit.edu	37	1	23660245	23660245	+	Intron	DEL	A	-	-			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:23660245delA	uc001bgr.3	-						HNRNPR_uc001bgp.3_Intron|HNRNPR_uc009vqk.2_Intron|HNRNPR_uc001bgs.3_Intron|HNRNPR_uc010odw.1_Intron|HNRNPR_uc010odx.1_Intron|HNRNPR_uc009vql.2_Intron	NM_005826	NP_005817			heterogeneous nuclear ribonucleoprotein R							catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00394)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;6.83e-27)|Colorectal(126;6.01e-08)|COAD - Colon adenocarcinoma(152;3.32e-06)|GBM - Glioblastoma multiforme(114;6.69e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00357)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0875)|LUSC - Lung squamous cell carcinoma(448;0.19)														---	---	---	---
BMP8A	353500	broad.mit.edu	37	1	39988318	39988319	+	Intron	INS	-	TTG	TTG	rs139401553	by1000genomes	TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:39988318_39988319insTTG	uc001cdi.2	+						PPIEL_uc001cdj.1_Intron|PPIEL_uc001cdk.2_Intron	NM_181809	NP_861525			bone morphogenetic protein 8A precursor						cartilage development|cell differentiation|growth|ossification	extracellular space	cytokine activity|growth factor activity				0	Lung NSC(20;2.08e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;9.69e-19)|Epithelial(16;9.34e-17)|all cancers(16;1.73e-15)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)															---	---	---	---
YBX1	4904	broad.mit.edu	37	1	43162182	43162183	+	Intron	INS	-	C	C	rs113762321		TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:43162182_43162183insC	uc001chs.2	+							NM_004559	NP_004550			nuclease sensitive element binding protein 1						CRD-mediated mRNA stabilization|negative regulation of transcription, DNA-dependent|nuclear mRNA splicing, via spliceosome|positive regulation of cell division|transcription from RNA polymerase II promoter	CRD-mediated mRNA stability complex|extracellular region|histone pre-mRNA 3'end processing complex|nucleoplasm|stress granule|U12-type spliceosomal complex	double-stranded DNA binding|protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			ovary(4)|upper_aerodigestive_tract(1)	5	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)																---	---	---	---
LOC200030	200030	broad.mit.edu	37	1	148011136	148011137	+	Intron	INS	-	T	T	rs148901736	by1000genomes	TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:148011136_148011137insT	uc001eqf.2	-						LOC200030_uc001eqe.2_Intron|LOC200030_uc001eqg.2_Intron|FLJ39739_uc001eqo.1_Intron|NBPF14_uc010pab.1_Intron|NBPF14_uc010pac.1_Intron|NBPF14_uc001eqx.2_Intron|NBPF14_uc001eqq.2_Intron|NBPF14_uc010pad.1_Intron|NBPF14_uc001eqs.1_Intron	NM_017940	NP_060410			hypothetical protein LOC55672							cytoplasm					0																		---	---	---	---
GATAD2B	57459	broad.mit.edu	37	1	153800932	153800939	+	Intron	DEL	ACACACAC	-	-	rs71677766		TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:153800932_153800939delACACACAC	uc001fdb.3	-							NM_020699	NP_065750			GATA zinc finger domain containing 2B							nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_lung(78;1.34e-32)|Lung NSC(65;1.04e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)															---	---	---	---
SRBD1	55133	broad.mit.edu	37	2	45645816	45645816	+	Intron	DEL	A	-	-			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:45645816delA	uc002rus.2	-						SRBD1_uc010yoc.1_Intron	NM_018079	NP_060549			S1 RNA binding domain 1						nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			central_nervous_system(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)															---	---	---	---
Unknown	0	broad.mit.edu	37	2	133020743	133020744	+	IGR	INS	-	T	T	rs137914230		TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:133020743_133020744insT								NCRNA00164 (5201 upstream) : GPR39 (153403 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	2	177065588	177065588	+	IGR	DEL	T	-	-			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:177065588delT								HOXD1 (9953 upstream) : MTX2 (68535 downstream)																																			---	---	---	---
SPINK2	6691	broad.mit.edu	37	4	57678104	57678104	+	Intron	DEL	T	-	-			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:57678104delT	uc003hcg.1	-							NM_021114	NP_066937			serine protease inhibitor, Kazal type 2							extracellular region	serine-type endopeptidase inhibitor activity				0	Glioma(25;0.08)|all_neural(26;0.181)																	---	---	---	---
UBA6	55236	broad.mit.edu	37	4	68531131	68531132	+	Intron	INS	-	T	T	rs72340884		TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:68531131_68531132insT	uc003hdg.3	-						UBA6_uc003hdi.2_Intron|UBA6_uc003hdj.2_Intron	NM_018227	NP_060697			ubiquitin-activating enzyme E1-like 2						protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding				0																		---	---	---	---
GALNT7	51809	broad.mit.edu	37	4	174235080	174235081	+	Intron	DEL	AT	-	-			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:174235080_174235081delAT	uc003isz.3	+						GALNT7_uc011ckb.1_Intron	NM_017423	NP_059119			polypeptide N-acetylgalactosaminyltransferase 7						protein O-linked glycosylation	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)	1		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;1.87e-18)|Epithelial(43;3.44e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-09)|STAD - Stomach adenocarcinoma(60;0.0019)|GBM - Glioblastoma multiforme(59;0.0119)|LUSC - Lung squamous cell carcinoma(193;0.0199)														---	---	---	---
TTC37	9652	broad.mit.edu	37	5	94834332	94834332	+	Intron	DEL	T	-	-	rs72354377		TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:94834332delT	uc003klb.2	-							NM_014639	NP_055454			tetratricopeptide repeat domain 37								binding			ovary(3)|pancreas(1)	4																		---	---	---	---
MAPK13	5603	broad.mit.edu	37	6	36098497	36098498	+	Intron	INS	-	GGGGGGC	GGGGGGC	rs146539855	by1000genomes	TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:36098497_36098498insGGGGGGC	uc003ols.2	+						MAPK13_uc003olt.2_Intron	NM_002754	NP_002745			mitogen-activated protein kinase 13						cell cycle|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|positive regulation of interleukin-6 production|Ras protein signal transduction|response to stress		ATP binding|MAP kinase activity|protein binding			breast(2)|central_nervous_system(1)	3																		---	---	---	---
CASP8AP2	9994	broad.mit.edu	37	6	90564511	90564512	+	Intron	INS	-	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:90564511_90564512insT	uc003pnr.2	+						CASP8AP2_uc003pns.2_Intron|CASP8AP2_uc003pnt.2_Intron|CASP8AP2_uc011dzz.1_Intron	NM_001137667	NP_001131139			caspase 8 associated protein 2						cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			ovary(2)	2		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)														---	---	---	---
RPS6KA2	6196	broad.mit.edu	37	6	166995598	166995598	+	Intron	DEL	G	-	-			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:166995598delG	uc003qvb.1	-						RPS6KA2_uc003qvc.1_Intron|RPS6KA2_uc003qvd.1_Intron	NM_021135	NP_066958			ribosomal protein S6 kinase, 90kDa, polypeptide						axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|skin(2)|large_intestine(1)|central_nervous_system(1)	8		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)														---	---	---	---
RAPGEF5	9771	broad.mit.edu	37	7	22194363	22194364	+	Intron	INS	-	T	T	rs150777301	by1000genomes	TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:22194363_22194364insT	uc003svg.2	-						RAPGEF5_uc011jyl.1_Intron	NM_012294	NP_036426			Rap guanine nucleotide exchange factor (GEF) 5						nervous system development|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	nucleus	GTP-dependent protein binding|Rap guanyl-nucleotide exchange factor activity			ovary(1)	1																		---	---	---	---
ASZ1	136991	broad.mit.edu	37	7	117020837	117020838	+	Intron	INS	-	AAAAAC	AAAAAC	rs147516910	by1000genomes	TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:117020837_117020838insAAAAAC	uc003vjb.2	-						ASZ1_uc011kno.1_Intron|ASZ1_uc011knp.1_Intron	NM_130768	NP_570124			ankyrin repeat, SAM and basic leucine zipper						cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(10;0.00156)|all_lung(10;0.00175)		STAD - Stomach adenocarcinoma(10;0.000512)															---	---	---	---
CREB3L2	64764	broad.mit.edu	37	7	137583787	137583788	+	Intron	INS	-	AAAAAGAAAGAAAG	AAAAAGAAAGAAAG	rs113900167		TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:137583787_137583788insAAAAAGAAAGAAAG	uc003vtw.2	-						CREB3L2_uc003vtx.1_Intron|CREB3L2_uc003vtv.2_Intron	NM_194071	NP_919047			cAMP responsive element binding protein 3-like						chondrocyte differentiation|positive regulation of transcription, DNA-dependent|response to endoplasmic reticulum stress|response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	cAMP response element binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L2(158)	soft_tissue(158)|upper_aerodigestive_tract(1)|ovary(1)	160								T	FUS	fibromyxoid sarcoma								---	---	---	---
Unknown	0	broad.mit.edu	37	9	68413567	68413567	+	RNA	DEL	G	-	-			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:68413567delG	uc004aex.2	+	1		c.122delG								Homo sapiens mRNA; cDNA DKFZp564N0763 (from clone DKFZp564N0763).																														---	---	---	---
SMC5	23137	broad.mit.edu	37	9	72895959	72895960	+	Intron	INS	-	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:72895959_72895960insT	uc004ahr.2	+							NM_015110	NP_055925			SMC5 protein						DNA recombination|DNA repair	chromosome|nucleus	ATP binding			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
Unknown	0	broad.mit.edu	37	10	51023458	51023458	+	IGR	DEL	A	-	-			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:51023458delA								OGDHL (53033 upstream) : PARG (2869 downstream)																																			---	---	---	---
BICC1	80114	broad.mit.edu	37	10	60273190	60273193	+	Intron	DEL	CGGC	-	-	rs10571555		TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:60273190_60273193delCGGC	uc001jki.1	+							NM_001080512	NP_001073981			bicaudal C homolog 1						multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4																		---	---	---	---
Unknown	0	broad.mit.edu	37	12	24737258	24737263	+	5'Flank	DEL	CCCCCA	-	-			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:24737258_24737263delCCCCCA	uc001rgb.1	-											Homo sapiens cDNA FLJ32894 fis, clone TESTI2004994.																														---	---	---	---
NAP1L1	4673	broad.mit.edu	37	12	76462515	76462516	+	Intron	INS	-	ACAC	ACAC	rs35120003		TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:76462515_76462516insACAC	uc001sxw.2	-						NAP1L1_uc001sxv.2_Intron|NAP1L1_uc001sxz.2_Intron|NAP1L1_uc001sxx.2_Intron|NAP1L1_uc001sxy.2_Intron|NAP1L1_uc010sty.1_Intron|NAP1L1_uc010stz.1_Intron|NAP1L1_uc010sua.1_Intron|NAP1L1_uc001syb.2_Intron|NAP1L1_uc001sya.2_Intron|NAP1L1_uc001syc.2_Intron	NM_139207	NP_631946			nucleosome assembly protein 1-like 1						DNA replication|nucleosome assembly|positive regulation of cell proliferation	chromatin assembly complex|melanosome	protein binding			ovary(1)|skin(1)	2		Colorectal(145;0.09)																---	---	---	---
TDG	6996	broad.mit.edu	37	12	104359899	104359900	+	Intron	DEL	GC	-	-			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:104359899_104359900delGC	uc001tkg.2	+						C12orf73_uc001tkf.3_5'Flank|TDG_uc010swh.1_Intron|TDG_uc009zuk.2_Intron|TDG_uc010swi.1_Intron	NM_003211	NP_003202			thymine-DNA glycosylase						depyrimidination|mismatch repair	nucleoplasm	damaged DNA binding|mismatched DNA binding|protein binding|pyrimidine-specific mismatch base pair DNA N-glycosylase activity			ovary(3)|lung(3)	6				BRCA - Breast invasive adenocarcinoma(302;0.00114)									BER_DNA_glycosylases					---	---	---	---
Unknown	0	broad.mit.edu	37	14	70270922	70270922	+	IGR	DEL	T	-	-	rs11429169		TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:70270922delT								SLC10A1 (6916 upstream) : SMOC1 (75221 downstream)																																			---	---	---	---
MYO9A	4649	broad.mit.edu	37	15	72208543	72208543	+	Intron	DEL	T	-	-			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:72208543delT	uc002atl.3	-						MYO9A_uc010biq.2_Intron|MYO9A_uc002atn.1_Intron	NM_006901	NP_008832			myosin IXA						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3																		---	---	---	---
PDZD9	255762	broad.mit.edu	37	16	22000249	22000250	+	Intron	INS	-	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:22000249_22000250insT	uc002dka.1	-							NM_173806	NP_776167			hypothetical protein LOC255762											pancreas(1)	1																		---	---	---	---
KIAA0182	23199	broad.mit.edu	37	16	85696457	85696457	+	Intron	DEL	G	-	-			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:85696457delG	uc002fix.2	+						KIAA0182_uc002fiw.2_Intron|KIAA0182_uc002fiy.2_Intron|KIAA0182_uc002fiz.2_5'UTR|KIAA0182_uc010cho.2_5'Flank	NM_014615	NP_055430			genetic suppressor element 1 isoform 1								protein binding			large_intestine(3)|ovary(1)|skin(1)	5																		---	---	---	---
Unknown	0	broad.mit.edu	37	16	87255723	87255725	+	Intron	DEL	CAC	-	-			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:87255723_87255725delCAC	uc002fjt.1	-											Homo sapiens cDNA FLJ43761 fis, clone TESTI2048109.																														---	---	---	---
Unknown	0	broad.mit.edu	37	17	7858584	7858584	+	IGR	DEL	A	-	-	rs78611358		TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7858584delA								CNTROB (5689 upstream) : GUCY2D (47404 downstream)																																			---	---	---	---
MYH4	4622	broad.mit.edu	37	17	10369087	10369087	+	Intron	DEL	C	-	-			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:10369087delC	uc002gmn.2	-						uc002gml.1_Intron	NM_017533	NP_060003			myosin, heavy polypeptide 4, skeletal muscle						muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13																		---	---	---	---
TSEN54	283989	broad.mit.edu	37	17	73513183	73513191	+	Intron	DEL	GCCCTCCCT	-	-	rs113075319		TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73513183_73513191delGCCCTCCCT	uc002jof.1	+						CASKIN2_uc002joc.2_5'Flank|CASKIN2_uc002jod.2_5'Flank|TSEN54_uc002joe.1_Intron	NM_207346	NP_997229			tRNA splicing endonuclease 54 homolog						mRNA processing|tRNA splicing, via endonucleolytic cleavage and ligation	nucleolus				ovary(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)															---	---	---	---
SLC25A41	284427	broad.mit.edu	37	19	6432329	6432330	+	Intron	INS	-	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6432329_6432330insT	uc010dus.2	-						SLC25A41_uc010dut.2_Intron	NM_173637	NP_775908			solute carrier family 25, member 41						transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	19	28388015	28388015	+	IGR	DEL	T	-	-			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:28388015delT								LOC148189 (103167 upstream) : None (None downstream)																																			---	---	---	---
ATP5SL	55101	broad.mit.edu	37	19	41938473	41938474	+	Intron	INS	-	GTGT	GTGT	rs149102482	by1000genomes	TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41938473_41938474insGTGT	uc002oqw.1	-						CYP2F1_uc010xvw.1_Intron|ATP5SL_uc002oqu.1_Intron|ATP5SL_uc002oqv.2_Intron|ATP5SL_uc010xwa.1_Intron|ATP5SL_uc002oqx.1_Intron|ATP5SL_uc002oqy.1_Intron|ATP5SL_uc002oqz.1_Intron|ATP5SL_uc002ora.1_3'UTR|ATP5SL_uc010xwb.1_3'UTR	NM_018035	NP_060505			ATP5S-like											large_intestine(1)|breast(1)	2																		---	---	---	---
PSG6	5675	broad.mit.edu	37	19	43579073	43579074	+	Intron	INS	-	TA	TA	rs61135205		TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:43579073_43579074insTA	uc002ovi.2	-						PSG6_uc010xwk.1_Intron|PSG2_uc002ovr.2_Intron|PSG2_uc002ovq.3_Intron|PSG2_uc010eiq.1_Intron|PSG2_uc002ovs.3_Intron|PSG2_uc002ovt.3_Intron					SubName: Full=Putative uncharacterized protein PSG6;						female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)																---	---	---	---
Unknown	0	broad.mit.edu	37	19	45036669	45036669	+	IGR	DEL	A	-	-			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:45036669delA								CEACAM20 (3121 upstream) : CEACAM22P (4376 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	20	8078534	8078534	+	IGR	DEL	A	-	-			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:8078534delA								TMX4 (78141 upstream) : PLCB1 (16566 downstream)																																			---	---	---	---
PLCG1	5335	broad.mit.edu	37	20	39794631	39794631	+	Intron	DEL	C	-	-	rs74464491		TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:39794631delC	uc002xjp.1	+						PLCG1_uc002xjo.1_Intron|PLCG1_uc010zwe.1_Intron|PLCG1_uc010ggf.2_5'Flank	NM_182811	NP_877963			phospholipase C, gamma 1 isoform b						activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			lung(3)|breast(3)|skin(2)	8		Myeloproliferative disorder(115;0.00878)																---	---	---	---
Unknown	0	broad.mit.edu	37	21	40499414	40499415	+	IGR	INS	-	T	T	rs147438953	by1000genomes	TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:40499414_40499415insT								ETS2 (302538 upstream) : PSMG1 (47975 downstream)																																			---	---	---	---
SNAP29	9342	broad.mit.edu	37	22	21241743	21241744	+	Intron	DEL	AC	-	-			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:21241743_21241744delAC	uc011ahw.1	+							NM_004782	NP_004773			synaptosomal-associated protein 29						cellular membrane fusion|exocytosis|protein transport|vesicle targeting	cell junction|cytoplasm|nucleus|synapse|synaptosome	SNAP receptor activity				0	all_cancers(11;2.77e-25)|all_epithelial(7;8.92e-24)|Lung NSC(8;1.49e-15)|all_lung(8;2.54e-14)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000592)|Lung(15;0.0117)															---	---	---	---
MLC1	23209	broad.mit.edu	37	22	50507155	50507155	+	Intron	DEL	T	-	-	rs72191777		TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:50507155delT	uc003bjg.1	-						MLC1_uc011arl.1_Intron|MLC1_uc003bjh.1_Intron|MLC1_uc011arm.1_Intron|MLC1_uc011arn.1_Intron|MLC1_uc011aro.1_Intron	NM_139202	NP_631941			megalencephalic leukoencephalopathy with							basolateral plasma membrane|endosome|integral to membrane|integral to membrane of membrane fraction	ion channel activity			pancreas(1)	1		all_cancers(38;7.69e-11)|all_epithelial(38;9.52e-10)|all_lung(38;3.67e-05)|Breast(42;0.000776)|Lung NSC(38;0.000946)|Ovarian(80;0.0365)|Lung SC(80;0.113)		READ - Rectum adenocarcinoma(2;0.000669)|Colorectal(2;0.00242)|LUAD - Lung adenocarcinoma(64;0.0695)|BRCA - Breast invasive adenocarcinoma(115;0.216)														---	---	---	---
SFRS17A	8227	broad.mit.edu	37	X	1715654	1715656	+	Intron	DEL	TCC	-	-			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:1715654_1715656delTCC	uc004cqa.2	+						SFRS17A_uc010ncx.1_Intron|SFRS17A_uc004cqb.2_Intron|ASMT_uc004cqd.2_Intron	NM_005088	NP_005079			DNA segment on chromosome X and Y (unique) 155						B cell activation|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|signal transduction	nuclear speck|spliceosomal complex	nucleotide binding|protein binding|RNA binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)																---	---	---	---
Unknown	0	broad.mit.edu	37	X	54868437	54868437	+	IGR	DEL	T	-	-			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:54868437delT								MAGED2 (25992 upstream) : TRO (78812 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	Y	28780698	28780699	+	IGR	INS	-	AG	AG			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrY:28780698_28780699insAG								None (None upstream) : None (None downstream)																																			---	---	---	---
DFFA	1676	broad.mit.edu	37	1	10527274	10527274	+	Silent	SNP	G	A	A			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:10527274G>A	uc001arj.2	-	3	512	c.414C>T	c.(412-414)ATC>ATT	p.I138I	DFFA_uc001ark.2_Silent_p.I138I	NM_004401	NP_004392	O00273	DFFA_HUMAN	DNA fragmentation factor, 45kDa, alpha	138					DNA fragmentation involved in apoptotic nuclear change|intracellular signal transduction|negative regulation of apoptosis	cytosol|mitochondrion|nucleoplasm|plasma membrane	deoxyribonuclease activity|identical protein binding				0	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.25e-07)|COAD - Colon adenocarcinoma(227;7.25e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000296)|Kidney(185;0.00074)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0487)														---	---	---	---
PRAMEF12	390999	broad.mit.edu	37	1	12837237	12837237	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:12837237C>T	uc001aui.2	+	3	974	c.947C>T	c.(946-948)CCG>CTG	p.P316L		NM_001080830	NP_001074299	O95522	PRA12_HUMAN	PRAME family member 12	316										ovary(3)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
AIM1L	55057	broad.mit.edu	37	1	26655305	26655305	+	Silent	SNP	G	A	A			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:26655305G>A	uc001bmd.3	-	15	1669	c.1239C>T	c.(1237-1239)ATC>ATT	p.I413I		NM_001039775	NP_001034864	Q8N1P7	AIM1L_HUMAN	absent in melanoma 1-like	413	Beta/gamma crystallin 'Greek key' 9.						sugar binding			pancreas(1)	1		all_cancers(24;4.67e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.51e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000792)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.00858)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.165)|LUSC - Lung squamous cell carcinoma(448;0.239)														---	---	---	---
CELSR2	1952	broad.mit.edu	37	1	109793708	109793708	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:109793708C>T	uc001dxa.3	+	1	1068	c.1007C>T	c.(1006-1008)CCC>CTC	p.P336L		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	336	Cadherin 2.|Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)														---	---	---	---
TRIM33	51592	broad.mit.edu	37	1	114940396	114940396	+	Silent	SNP	G	A	A			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:114940396G>A	uc001eew.2	-	20	3342	c.3258C>T	c.(3256-3258)TTC>TTT	p.F1086F	TRIM33_uc010owr.1_Silent_p.F700F|TRIM33_uc010ows.1_Silent_p.F718F|TRIM33_uc001eex.2_Silent_p.F1069F	NM_015906	NP_056990	Q9UPN9	TRI33_HUMAN	tripartite motif-containing 33 protein isoform	1086					negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	nucleus	co-SMAD binding|DNA binding|ligase activity|R-SMAD binding|zinc ion binding			lung(4)|central_nervous_system(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	11	all_epithelial(7;0.000132)|all_lung(7;0.00106)|Lung SC(450;0.184)	all_cancers(81;3.03e-08)|all_epithelial(167;3.24e-08)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)				T	RET	papillary thyroid								---	---	---	---
CD1E	913	broad.mit.edu	37	1	158325888	158325888	+	Missense_Mutation	SNP	C	G	G			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:158325888C>G	uc001fse.2	+	4	1136	c.897C>G	c.(895-897)ATC>ATG	p.I299M	CD1E_uc010pid.1_Missense_Mutation_p.I297M|CD1E_uc010pie.1_Missense_Mutation_p.I200M|CD1E_uc010pif.1_Missense_Mutation_p.I110M|CD1E_uc001fsd.2_Intron|CD1E_uc001fsk.2_Missense_Mutation_p.I209M|CD1E_uc001fsj.2_Intron|CD1E_uc001fsc.2_Missense_Mutation_p.I110M|CD1E_uc010pig.1_Intron|CD1E_uc001fsa.2_Intron|CD1E_uc001fsf.2_Missense_Mutation_p.I299M|CD1E_uc001fry.2_Intron|CD1E_uc001fsg.2_Intron|CD1E_uc001fsh.2_Missense_Mutation_p.I110M|CD1E_uc001fsi.2_Intron|CD1E_uc009wsv.2_Missense_Mutation_p.I200M|CD1E_uc001frz.2_Missense_Mutation_p.I209M|CD1E_uc009wsw.2_Missense_Mutation_p.I57M	NM_030893	NP_112155	P15812	CD1E_HUMAN	CD1E antigen isoform a precursor	299	Ig-like.				antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				skin(3)	3	all_hematologic(112;0.0378)																	---	---	---	---
QSOX1	5768	broad.mit.edu	37	1	180163539	180163539	+	Intron	SNP	C	G	G			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:180163539C>G	uc001gnz.2	+						QSOX1_uc001gny.2_Intron|QSOX1_uc001goa.2_Intron|QSOX1_uc001goc.2_Intron	NM_002826	NP_002817			quiescin Q6 sulfhydryl oxidase 1 isoform a						cell redox homeostasis|protein thiol-disulfide exchange	extracellular space|integral to Golgi membrane	flavin-linked sulfhydryl oxidase activity			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
CHI3L1	1116	broad.mit.edu	37	1	203152776	203152776	+	Missense_Mutation	SNP	A	G	G			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:203152776A>G	uc001gzi.2	-	5	629	c.458T>C	c.(457-459)CTA>CCA	p.L153P	FMOD_uc010pqi.1_Intron|CHI3L1_uc001gzk.1_5'Flank|CHI3L1_uc001gzj.2_Missense_Mutation_p.L153P	NM_001276	NP_001267	P36222	CH3L1_HUMAN	chitinase 3-like 1 precursor	153					chitin catabolic process	extracellular space|proteinaceous extracellular matrix	cation binding|chitinase activity|extracellular matrix structural constituent|sugar binding			pancreas(1)	1																		---	---	---	---
NFASC	23114	broad.mit.edu	37	1	204966334	204966334	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:204966334C>T	uc001hbj.2	+	25	3147	c.2819C>T	c.(2818-2820)ACG>ATG	p.T940M	NFASC_uc010pra.1_Intron|NFASC_uc001hbi.2_Intron|NFASC_uc010prb.1_Intron|NFASC_uc010prc.1_Intron|NFASC_uc001hbl.1_Intron|NFASC_uc001hbm.1_Intron|NFASC_uc001hbn.1_Missense_Mutation_p.T86M|NFASC_uc009xbh.1_Translation_Start_Site	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	997	Extracellular (Potential).|Fibronectin type-III 4.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)															---	---	---	---
MARK1	4139	broad.mit.edu	37	1	220824034	220824034	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:220824034G>A	uc001hmn.3	+	14	2140	c.1543G>A	c.(1543-1545)GTA>ATA	p.V515I	MARK1_uc009xdw.2_Missense_Mutation_p.V515I|MARK1_uc010pun.1_Missense_Mutation_p.V515I|MARK1_uc001hmm.3_Missense_Mutation_p.V493I	NM_018650	NP_061120	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	515					intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(4)|central_nervous_system(2)|skin(2)|stomach(1)|lung(1)	10				GBM - Glioblastoma multiforme(131;0.0407)														---	---	---	---
KIAA1383	54627	broad.mit.edu	37	1	232942122	232942122	+	Missense_Mutation	SNP	G	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:232942122G>T	uc001hvh.2	+	1	1485	c.1353G>T	c.(1351-1353)TTG>TTT	p.L451F		NM_019090	NP_061963	Q9P2G4	K1383_HUMAN	hypothetical protein LOC54627	309										ovary(1)	1		all_cancers(173;0.00528)|Prostate(94;0.122)|all_epithelial(177;0.169)																---	---	---	---
NID1	4811	broad.mit.edu	37	1	236142365	236142365	+	Silent	SNP	C	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:236142365C>T	uc001hxo.2	-	19	3654	c.3552G>A	c.(3550-3552)ACG>ACA	p.T1184T	NID1_uc009xgd.2_Silent_p.T1051T|NID1_uc009xgc.2_Silent_p.T265T	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	1184					cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)													---	---	---	---
FMN2	56776	broad.mit.edu	37	1	240256644	240256644	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:240256644C>T	uc010pyd.1	+	1	1460	c.1235C>T	c.(1234-1236)CCG>CTG	p.P412L	FMN2_uc010pye.1_Missense_Mutation_p.P412L	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	412					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)															---	---	---	---
PLEK	5341	broad.mit.edu	37	2	68613709	68613709	+	Missense_Mutation	SNP	C	T	T	rs148824923		TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:68613709C>T	uc002sen.3	+	5	710	c.548C>T	c.(547-549)TCG>TTG	p.S183L	PLEK_uc010fde.2_Missense_Mutation_p.S183L	NM_002664	NP_002655	P08567	PLEK_HUMAN	pleckstrin	183	DEP.				actin cytoskeleton reorganization|cortical actin cytoskeleton organization|hemopoietic progenitor cell differentiation|inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway|integrin-mediated signaling pathway|negative regulation of calcium-mediated signaling|negative regulation of inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|platelet aggregation|positive regulation of actin filament bundle assembly|positive regulation of actin filament depolymerization|positive regulation of inositol-polyphosphate 5-phosphatase activity|positive regulation of integrin activation|positive regulation of platelet activation|protein kinase C signaling cascade|protein secretion by platelet|regulation of cell diameter|ruffle organization|thrombin receptor signaling pathway|vesicle docking involved in exocytosis	cytosol|extracellular region|membrane fraction|ruffle membrane|soluble fraction	phosphatidylinositol-3,4-bisphosphate binding|protein homodimerization activity|protein kinase C binding			ovary(1)	1		Ovarian(717;0.0129)		STAD - Stomach adenocarcinoma(1183;0.00159)|READ - Rectum adenocarcinoma(193;0.0419)														---	---	---	---
ZEB2	9839	broad.mit.edu	37	2	145274864	145274864	+	Silent	SNP	G	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:145274864G>T	uc002tvu.2	-	2	534	c.54C>A	c.(52-54)GCC>GCA	p.A18A	ZEB2_uc002tvv.2_Silent_p.A13A|ZEB2_uc010zbm.1_Silent_p.A13A|ZEB2_uc010fnp.2_Silent_p.A13A|ZEB2_uc010fnq.1_Silent_p.A47A|ZEB2_uc002tvw.2_Silent_p.A13A|ZEB2_uc002tvx.1_RNA|ZEB2_uc002tvy.2_Silent_p.A47A|ZEB2_uc002tvz.2_RNA|ZEB2_uc002twa.2_RNA	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	18						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)														---	---	---	---
ABCB11	8647	broad.mit.edu	37	2	169791908	169791908	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:169791908G>A	uc002ueo.1	-	23	2968	c.2842C>T	c.(2842-2844)CGC>TGC	p.R948C	ABCB11_uc010zda.1_Missense_Mutation_p.R390C|ABCB11_uc010zdb.1_Missense_Mutation_p.R424C	NM_003742	NP_003733	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	948	Cytoplasmic (Potential).|ABC transmembrane type-1 2.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			ovary(2)|large_intestine(2)|breast(1)	5					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)													---	---	---	---
CXCR1	3577	broad.mit.edu	37	2	219029327	219029327	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:219029327C>T	uc002vhc.2	-	2	727	c.608G>A	c.(607-609)CGG>CAG	p.R203Q		NM_000634	NP_000625	P25024	CXCR1_HUMAN	interleukin 8 receptor alpha	203	Helical; Name=5; (Potential).				dendritic cell chemotaxis|inflammatory response	integral to membrane|plasma membrane	interleukin-8 receptor activity			lung(2)	2																		---	---	---	---
COL4A4	1286	broad.mit.edu	37	2	227875130	227875130	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:227875130G>A	uc010zlt.1	-	45	5075	c.4421C>T	c.(4420-4422)ACG>ATG	p.T1474M		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	1474	Collagen IV NC1.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)														---	---	---	---
HDLBP	3069	broad.mit.edu	37	2	242196205	242196205	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:242196205G>A	uc002waz.2	-	6	695	c.467C>T	c.(466-468)GCC>GTC	p.A156V	HDLBP_uc002wba.2_Missense_Mutation_p.A156V|HDLBP_uc002wbb.2_Missense_Mutation_p.A177V|HDLBP_uc010fzn.1_5'UTR	NM_203346	NP_976221	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	156					cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(3)|skin(1)	4		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)														---	---	---	---
SETD2	29072	broad.mit.edu	37	3	47155459	47155459	+	Missense_Mutation	SNP	T	C	C			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:47155459T>C	uc003cqs.2	-	5	4675	c.4622A>G	c.(4621-4623)AAT>AGT	p.N1541S	SETD2_uc003cqv.2_Missense_Mutation_p.N1530S	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1541	AWS.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)				N|F|S|Mis		clear cell renal carcinoma								---	---	---	---
LAMB2	3913	broad.mit.edu	37	3	49167420	49167420	+	Silent	SNP	G	A	A	rs146643686		TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49167420G>A	uc003cwe.2	-	10	1556	c.1257C>T	c.(1255-1257)GAC>GAT	p.D419D	LAMB2_uc003cwf.1_Silent_p.D419D	NM_002292	NP_002283	P55268	LAMB2_HUMAN	laminin, beta 2 precursor	419	Laminin EGF-like 3.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)														---	---	---	---
PPARGC1A	10891	broad.mit.edu	37	4	23815403	23815403	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:23815403C>T	uc003gqs.2	-	8	1823	c.1703G>A	c.(1702-1704)CGT>CAT	p.R568H	PPARGC1A_uc003gqt.2_RNA|PPARGC1A_uc011bxp.1_RNA|PPARGC1A_uc010ier.1_RNA	NM_013261	NP_037393	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor	568	Arg/Ser-rich.				androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			ovary(2)|lung(2)|kidney(2)|skin(2)	8		Breast(46;0.0503)																---	---	---	---
CORIN	10699	broad.mit.edu	37	4	47746513	47746513	+	Silent	SNP	C	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:47746513C>T	uc003gxm.2	-	5	798	c.705G>A	c.(703-705)CCG>CCA	p.P235P	CORIN_uc011bzf.1_Silent_p.P96P|CORIN_uc011bzg.1_Silent_p.P168P|CORIN_uc011bzh.1_Silent_p.P235P|CORIN_uc011bzi.1_Silent_p.P235P|CORIN_uc003gxn.3_Silent_p.P235P	NM_006587	NP_006578	Q9Y5Q5	CORIN_HUMAN	corin	235	Extracellular (Potential).|FZ 1.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
UGT2A1	10941	broad.mit.edu	37	4	70455255	70455255	+	Missense_Mutation	SNP	G	C	C			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:70455255G>C	uc003hem.3	-	6	1482	c.1419C>G	c.(1417-1419)CAC>CAG	p.H473Q	UGT2A1_uc011caq.1_Missense_Mutation_p.H639Q|UGT2A1_uc010ihu.2_Missense_Mutation_p.H473Q|UGT2A1_uc010iht.2_Missense_Mutation_p.H429Q|UGT2A1_uc010ihs.2_Missense_Mutation_p.H474Q	NM_006798	NP_006789	Q9Y4X1	UD2A1_HUMAN	UDP glucuronosyltransferase 2 family,	473	Extracellular (Potential).				detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity|glucuronosyltransferase activity			ovary(1)	1																		---	---	---	---
EREG	2069	broad.mit.edu	37	4	75246757	75246757	+	Missense_Mutation	SNP	G	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:75246757G>T	uc003hie.1	+	3	347	c.181G>T	c.(181-183)GCT>TCT	p.A61S	EREG_uc003hid.2_Missense_Mutation_p.A55S	NM_001432	NP_001423	O14944	EREG_HUMAN	epiregulin preproprotein	61	Extracellular (Potential).				angiogenesis|cell-cell signaling|cytokine-mediated signaling pathway|epidermal growth factor receptor signaling pathway|female meiosis|keratinocyte differentiation|keratinocyte proliferation|luteinizing hormone signaling pathway|mRNA transcription|negative regulation of epithelial cell proliferation|negative regulation of smooth muscle cell differentiation|negative regulation of transcription, DNA-dependent|oocyte maturation|organ morphogenesis|ovarian cumulus expansion|ovulation|positive regulation of cell division|positive regulation of cytokine production|positive regulation of DNA replication|positive regulation of epidermal growth factor receptor activity|positive regulation of fibroblast proliferation|positive regulation of innate immune response|positive regulation of interleukin-6 biosynthetic process|positive regulation of mitosis|positive regulation of phosphorylation|positive regulation of smooth muscle cell proliferation|primary follicle stage|wound healing	extracellular space|integral to plasma membrane	epidermal growth factor receptor binding|growth factor activity			breast(1)|skin(1)	2			Lung(101;0.196)															---	---	---	---
TRIML1	339976	broad.mit.edu	37	4	189068387	189068387	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:189068387G>A	uc003izm.1	+	6	1383	c.1268G>A	c.(1267-1269)GGG>GAG	p.G423E	TRIML1_uc003izn.1_Missense_Mutation_p.G147E	NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	423	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)														---	---	---	---
EGFLAM	133584	broad.mit.edu	37	5	38448485	38448485	+	Intron	SNP	A	C	C			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:38448485A>C	uc003jlc.1	+						EGFLAM_uc003jlb.1_Intron|EGFLAM_uc003jle.1_Intron|EGFLAM_uc003jlf.1_Intron|EGFLAM_uc003jlg.1_Intron	NM_152403	NP_689616			EGF-like, fibronectin type III and laminin G							cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)																	---	---	---	---
EMB	133418	broad.mit.edu	37	5	49699147	49699147	+	Nonsense_Mutation	SNP	C	A	A			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:49699147C>A	uc003jom.2	-	6	991	c.742G>T	c.(742-744)GAA>TAA	p.E248*	EMB_uc010ivq.2_Nonsense_Mutation_p.E42*|EMB_uc003jol.2_Nonsense_Mutation_p.E179*|EMB_uc011cpy.1_Nonsense_Mutation_p.E198*|EMB_uc010ivr.2_Nonsense_Mutation_p.E194*	NM_198449	NP_940851	Q6PCB8	EMB_HUMAN	embigin precursor	248	Extracellular (Potential).|Ig-like V-type 2.					integral to membrane					0	Lung SC(58;0.218)	Lung NSC(810;0.0795)																---	---	---	---
ANKRD55	79722	broad.mit.edu	37	5	55407441	55407441	+	Silent	SNP	G	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:55407441G>T	uc003jqu.2	-	10	1286	c.1134C>A	c.(1132-1134)GTC>GTA	p.V378V	ANKRD55_uc003jqt.2_Silent_p.V90V	NM_024669	NP_078945	Q3KP44	ANR55_HUMAN	ankyrin repeat domain 55 isoform 1	377										skin(1)	1		Lung NSC(810;8.69e-05)|Prostate(74;0.00634)|Breast(144;0.0334)|Ovarian(174;0.223)																---	---	---	---
NLN	57486	broad.mit.edu	37	5	65088312	65088312	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:65088312G>A	uc003juf.2	+	9	1473	c.1357G>A	c.(1357-1359)GGT>AGT	p.G453S	NLN_uc003jue.2_Missense_Mutation_p.G453S|NLN_uc003jug.2_Missense_Mutation_p.G282S|NLN_uc010iww.2_Missense_Mutation_p.G148S	NM_020726	NP_065777	Q9BYT8	NEUL_HUMAN	neurolysin precursor	453					proteolysis	mitochondrial intermembrane space	metal ion binding|metalloendopeptidase activity			central_nervous_system(1)	1		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0743)|Lung(70;0.00616)														---	---	---	---
TTC37	9652	broad.mit.edu	37	5	94852045	94852045	+	Intron	SNP	C	A	A			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:94852045C>A	uc003klb.2	-							NM_014639	NP_055454			tetratricopeptide repeat domain 37								binding			ovary(3)|pancreas(1)	4																		---	---	---	---
SEC24A	10802	broad.mit.edu	37	5	134044579	134044579	+	Splice_Site	SNP	G	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:134044579G>T	uc003kzs.2	+	18	3015	c.2727_splice	c.e18+1	p.Q909_splice	SEC24A_uc011cxu.1_Splice_Site_p.Q673_splice	NM_021982	NP_068817			SEC24 related gene family, member A						COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)															---	---	---	---
EBF1	1879	broad.mit.edu	37	5	158250178	158250178	+	Intron	SNP	G	A	A			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:158250178G>A	uc010jip.2	-						EBF1_uc011ddw.1_Intron|EBF1_uc011ddx.1_Intron|EBF1_uc003lxl.3_Intron	NM_024007	NP_076870			early B-cell factor						multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	soft_tissue(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)					T	HMGA2	lipoma								---	---	---	---
SLC35B3	51000	broad.mit.edu	37	6	8430176	8430176	+	Missense_Mutation	SNP	C	A	A			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:8430176C>A	uc010joe.2	-	3	384	c.218G>T	c.(217-219)AGC>ATC	p.S73I	SLC35B3_uc003mya.2_Missense_Mutation_p.S41I|SLC35B3_uc003myc.2_RNA|SLC35B3_uc003myb.2_Missense_Mutation_p.S73I|SLC35B3_uc011did.1_Missense_Mutation_p.S73I|SLC35B3_uc003myd.2_RNA|SLC35B3_uc010jof.2_Missense_Mutation_p.S41I|SLC35B3_uc011die.1_Missense_Mutation_p.S73I	NM_001142541	NP_001136013	Q9H1N7	S35B3_HUMAN	solute carrier family 35, member B3	73					transmembrane transport	Golgi membrane|integral to membrane					0	Ovarian(93;0.0569)																	---	---	---	---
OR5V1	81696	broad.mit.edu	37	6	29323192	29323192	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:29323192G>A	uc011dlo.1	-	1	863	c.781C>T	c.(781-783)CGG>TGG	p.R261W		NM_030876	NP_110503	Q9UGF6	OR5V1_HUMAN	olfactory receptor, family 5, subfamily V,	261	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R261Q(1)		ovary(3)|kidney(1)	4																		---	---	---	---
LY6G6C	80740	broad.mit.edu	37	6	31686897	31686897	+	Silent	SNP	G	C	C			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:31686897G>C	uc003nwh.2	-	3	408	c.354C>G	c.(352-354)GGC>GGG	p.G118G	LY6G6C_uc010jtd.2_RNA	NM_025261	NP_079537	O95867	LY66C_HUMAN	lymphocyte antigen 6 complex G6C precursor	118						anchored to membrane|plasma membrane					0																		---	---	---	---
GFRAL	389400	broad.mit.edu	37	6	55216354	55216354	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:55216354G>A	uc003pcm.1	+	5	760	c.674G>A	c.(673-675)CGC>CAC	p.R225H		NM_207410	NP_997293	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like precursor	225	Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|breast(1)	2	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)															---	---	---	---
HIVEP2	3097	broad.mit.edu	37	6	143095264	143095264	+	Silent	SNP	C	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:143095264C>T	uc003qjd.2	-	5	1355	c.612G>A	c.(610-612)CTG>CTA	p.L204L		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	204	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)														---	---	---	---
DLL1	28514	broad.mit.edu	37	6	170594221	170594221	+	Missense_Mutation	SNP	A	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:170594221A>T	uc003qxm.2	-	8	1505	c.1035T>A	c.(1033-1035)GAT>GAA	p.D345E		NM_005618	NP_005609	O00548	DLL1_HUMAN	delta-like 1 precursor	345	Extracellular (Potential).|EGF-like 4; calcium-binding (Potential).				cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			lung(4)|ovary(1)	5		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)														---	---	---	---
SDK1	221935	broad.mit.edu	37	7	4273010	4273010	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:4273010C>T	uc003smx.2	+	41	6090	c.5951C>T	c.(5950-5952)GCG>GTG	p.A1984V	SDK1_uc010kso.2_Missense_Mutation_p.A1240V|SDK1_uc003smy.2_Missense_Mutation_p.A471V|SDK1_uc003smz.2_Missense_Mutation_p.A44V	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1984	Fibronectin type-III 13.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)														---	---	---	---
C7orf16	10842	broad.mit.edu	37	7	31735216	31735216	+	Silent	SNP	C	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:31735216C>T	uc003tcl.2	+	3	374	c.216C>T	c.(214-216)CAC>CAT	p.H72H	C7orf16_uc011kaf.1_Intron	NM_006658	NP_006649	O96001	GSUB_HUMAN	G-substrate isoform 1	72					behavior|central nervous system development|intracellular protein kinase cascade|protein phosphorylation	soluble fraction				ovary(2)|central_nervous_system(1)	3			GBM - Glioblastoma multiforme(11;0.216)															---	---	---	---
LAMB1	3912	broad.mit.edu	37	7	107572693	107572693	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:107572693C>T	uc003vew.2	-	28	4653	c.4318G>A	c.(4318-4320)GCC>ACC	p.A1440T	LAMB1_uc003vev.2_Missense_Mutation_p.A1464T|LAMB1_uc003veu.2_5'Flank	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	1440	Domain I.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
MLL3	58508	broad.mit.edu	37	7	151917829	151917829	+	Intron	SNP	A	G	G			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:151917829A>G	uc003wla.2	-						MLL3_uc003wkz.2_Intron	NM_170606	NP_733751			myeloid/lymphoid or mixed-lineage leukemia 3						intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)				N		medulloblastoma								---	---	---	---
TMEM215	401498	broad.mit.edu	37	9	32784506	32784506	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:32784506G>A	uc003zri.3	+	2	690	c.325G>A	c.(325-327)GAT>AAT	p.D109N		NM_212558	NP_997723	Q68D42	TM215_HUMAN	transmembrane protein 215	109						integral to membrane					0																		---	---	---	---
KIAA1045	23349	broad.mit.edu	37	9	34976588	34976588	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:34976588G>A	uc003zvq.2	+	5	878	c.700G>A	c.(700-702)GGG>AGG	p.G234R	KIAA1045_uc003zvr.2_Missense_Mutation_p.G234R	NM_015297	NP_056112	Q9UPV7	K1045_HUMAN	hypothetical protein LOC23349	234							calcium ion binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00575)															---	---	---	---
IARS	3376	broad.mit.edu	37	9	95004524	95004524	+	Missense_Mutation	SNP	G	C	C			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:95004524G>C	uc004art.1	-	29	3346	c.3089C>G	c.(3088-3090)ACA>AGA	p.T1030R	IARS_uc004ars.1_Missense_Mutation_p.T875R|IARS_uc004aru.3_Missense_Mutation_p.T1030R|IARS_uc010mqr.2_Missense_Mutation_p.T920R|IARS_uc010mqt.2_Missense_Mutation_p.T253R	NM_013417	NP_038203	P41252	SYIC_HUMAN	isoleucine tRNA synthetase	1030					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			ovary(1)|skin(1)	2					L-Isoleucine(DB00167)													---	---	---	---
OR1L4	254973	broad.mit.edu	37	9	125487043	125487043	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:125487043G>A	uc004bmu.1	+	1	775	c.775G>A	c.(775-777)GTC>ATC	p.V259I		NM_001005235	NP_001005235	Q8NGR5	OR1L4_HUMAN	olfactory receptor, family 1, subfamily L,	259	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0																		---	---	---	---
CNNM1	26507	broad.mit.edu	37	10	101124191	101124191	+	Silent	SNP	G	A	A			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:101124191G>A	uc001kpp.3	+	5	2335	c.2046G>A	c.(2044-2046)GAG>GAA	p.E682E	CNNM1_uc009xwe.2_Silent_p.E682E|CNNM1_uc010qpi.1_Silent_p.E682E|CNNM1_uc009xwf.2_Silent_p.E682E|CNNM1_uc009xwg.2_Silent_p.E82E	NM_020348	NP_065081	Q9NRU3	CNNM1_HUMAN	cyclin M1	682					ion transport	integral to membrane|plasma membrane					0		Colorectal(252;0.234)		Epithelial(162;6.82e-10)|all cancers(201;5.62e-08)														---	---	---	---
DENND5A	23258	broad.mit.edu	37	11	9192306	9192306	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:9192306C>T	uc001mhl.2	-	9	2180	c.1925G>A	c.(1924-1926)CGT>CAT	p.R642H	DENND5A_uc001mhk.2_5'UTR|DENND5A_uc010rbw.1_Missense_Mutation_p.R642H|DENND5A_uc010rbx.1_RNA	NM_015213	NP_056028	Q6IQ26	DEN5A_HUMAN	RAB6 interacting protein 1	642										liver(1)	1																		---	---	---	---
ARHGEF17	9828	broad.mit.edu	37	11	73073078	73073078	+	Intron	SNP	C	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:73073078C>T	uc001otu.2	+							NM_014786	NP_055601			Rho guanine nucleotide exchange factor (GEF) 17						actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0																		---	---	---	---
PDE3A	5139	broad.mit.edu	37	12	20769164	20769164	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:20769164C>T	uc001reh.1	+	4	1292	c.1270C>T	c.(1270-1272)CGC>TGC	p.R424C		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	424					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)													---	---	---	---
LRRK2	120892	broad.mit.edu	37	12	40697868	40697868	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:40697868T>G	uc001rmg.3	+	27	3830	c.3709T>G	c.(3709-3711)TTG>GTG	p.L1237V	LRRK2_uc001rmh.1_Missense_Mutation_p.L859V|LRRK2_uc009zjw.2_Missense_Mutation_p.L75V|LRRK2_uc001rmi.2_Missense_Mutation_p.L70V	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1237	LRR 10.				activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)																---	---	---	---
ZBTB39	9880	broad.mit.edu	37	12	57398420	57398420	+	Silent	SNP	T	C	C			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57398420T>C	uc001sml.1	-	2	368	c.282A>G	c.(280-282)ACA>ACG	p.T94T	RDH16_uc010sqx.1_5'Flank	NM_014830	NP_055645	O15060	ZBT39_HUMAN	zinc finger and BTB domain containing 39	94	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1																		---	---	---	---
CAND1	55832	broad.mit.edu	37	12	67699937	67699937	+	Missense_Mutation	SNP	C	G	G			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:67699937C>G	uc001stn.2	+	10	2926	c.2489C>G	c.(2488-2490)TCT>TGT	p.S830C	CAND1_uc001sto.2_Missense_Mutation_p.S340C	NM_018448	NP_060918	Q86VP6	CAND1_HUMAN	TIP120 protein	830	HEAT 19.				cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)														---	---	---	---
RIC8B	55188	broad.mit.edu	37	12	107209073	107209073	+	Silent	SNP	G	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:107209073G>T	uc001tlx.2	+	3	857	c.732G>T	c.(730-732)GTG>GTT	p.V244V	RIC8B_uc001tlw.2_Silent_p.V244V|RIC8B_uc001tly.2_Silent_p.V204V|RIC8B_uc001tlz.2_RNA	NM_018157	NP_060627	Q9NVN3	RIC8B_HUMAN	resistance to inhibitors of cholinesterase 8	244					regulation of G-protein coupled receptor protein signaling pathway	cell cortex|cytosol|plasma membrane	G-protein alpha-subunit binding|guanyl-nucleotide exchange factor activity			ovary(1)	1																		---	---	---	---
PRDM4	11108	broad.mit.edu	37	12	108134886	108134886	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:108134886T>G	uc001tmp.2	-	10	2198	c.1761A>C	c.(1759-1761)GAA>GAC	p.E587D	PRDM4_uc010sww.1_5'UTR|PRDM4_uc001tmq.2_RNA	NM_012406	NP_036538	Q9UKN5	PRDM4_HUMAN	PR domain containing 4	587					cell proliferation|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2																		---	---	---	---
ALOX5AP	241	broad.mit.edu	37	13	31326239	31326239	+	Missense_Mutation	SNP	C	T	T	rs148308449		TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:31326239C>T	uc001utf.1	+	3	295	c.221C>T	c.(220-222)GCG>GTG	p.A74V	ALOX5AP_uc010tdr.1_Missense_Mutation_p.A131V	NM_001629	NP_001620	P20292	AL5AP_HUMAN	arachidonate 5-lipoxygenase-activating protein	74	Helical.				cellular response to calcium ion|leukotriene biosynthetic process|leukotriene production involved in inflammatory response|protein homotrimerization	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	arachidonic acid binding|protein N-terminus binding				0		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0187)|Epithelial(112;0.0803)|OV - Ovarian serous cystadenocarcinoma(117;0.0864)														---	---	---	---
KBTBD6	89890	broad.mit.edu	37	13	41705946	41705946	+	Missense_Mutation	SNP	C	G	G			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:41705946C>G	uc001uxu.1	-	1	991	c.702G>C	c.(700-702)GAG>GAC	p.E234D	KBTBD6_uc010ace.1_Intron|KBTBD6_uc010tfe.1_Missense_Mutation_p.E168D|uc001uxv.1_5'Flank	NM_152903	NP_690867	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain-containing 6	234							protein binding			ovary(1)|skin(1)	2		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)														---	---	---	---
EDNRB	1910	broad.mit.edu	37	13	78492238	78492238	+	Silent	SNP	G	A	A			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:78492238G>A	uc001vko.2	-	1	729	c.471C>T	c.(469-471)ATC>ATT	p.I157I	uc001vks.2_5'Flank|EDNRB_uc001vkq.1_Silent_p.I157I|EDNRB_uc010aez.1_Silent_p.I157I|EDNRB_uc001vkp.1_Silent_p.I240I|EDNRB_uc010afa.1_Silent_p.I157I	NM_001122659	NP_001116131	P24530	EDNRB_HUMAN	endothelin receptor type B isoform 1 precursor	157	Helical; Name=2; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|enteric nervous system development|enteric smooth muscle cell differentiation|macrophage chemotaxis|negative regulation of adenylate cyclase activity|negative regulation of cellular protein metabolic process|negative regulation of neuron maturation|negative regulation of transcription from RNA polymerase II promoter|vein smooth muscle contraction	integral to plasma membrane	endothelin-B receptor activity|peptide hormone binding				0		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0933)	Bosentan(DB00559)													---	---	---	---
TPP2	7174	broad.mit.edu	37	13	103295620	103295620	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:103295620T>G	uc001vpi.3	+	17	2172	c.2069T>G	c.(2068-2070)CTA>CGA	p.L690R		NM_003291	NP_003282	P29144	TPP2_HUMAN	tripeptidyl peptidase II	690					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)																	---	---	---	---
KIAA1409	57578	broad.mit.edu	37	14	94053116	94053116	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:94053116A>C	uc001ybv.1	+	19	2446	c.2363A>C	c.(2362-2364)AAG>ACG	p.K788T	KIAA1409_uc001ybs.1_Missense_Mutation_p.K788T	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	965						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)														---	---	---	---
MIR379	494328	broad.mit.edu	37	14	101488430	101488430	+	RNA	SNP	G	A	A	rs115827677	by1000genomes	TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:101488430G>A	hsa-mir-379|MI0000787	+			c.28G>A			uc010awa.1_RNA|MIR411_hsa-mir-411|MI0003675_5'Flank|uc001yjx.1_5'Flank|MIR299_hsa-mir-299|MI0000744_5'Flank|uc010awb.1_5'Flank|MIR380_hsa-mir-380|MI0000788_5'Flank																	0																		---	---	---	---
Unknown	0	broad.mit.edu	37	15	25481277	25481277	+	5'Flank	SNP	C	G	G			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:25481277C>G	uc001zae.2	+						SNORD115-11_uc001zad.1_RNA|SNORD115-37_uc001zaf.1_5'Flank					Homo sapiens clone Rt-16 SNURF-SNRPN mRNA, downstream untranslated exons, alternatively spliced.																														---	---	---	---
ZSCAN29	146050	broad.mit.edu	37	15	43656493	43656493	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:43656493C>T	uc001zrk.1	-	4	1457	c.1310G>A	c.(1309-1311)CGC>CAC	p.R437H	ZSCAN29_uc001zrj.1_Missense_Mutation_p.R317H|ZSCAN29_uc010bdf.1_Missense_Mutation_p.R436H|ZSCAN29_uc001zrl.1_RNA|ZSCAN29_uc010bdg.1_Intron|ZSCAN29_uc001zrm.2_3'UTR	NM_152455	NP_689668	Q8IWY8	ZSC29_HUMAN	zinc finger protein 690	437					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.97e-07)														---	---	---	---
FANCI	55215	broad.mit.edu	37	15	89837116	89837116	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:89837116T>G	uc010bnp.1	+	23	2434	c.2344T>G	c.(2344-2346)TCT>GCT	p.S782A	FANCI_uc002bnm.1_Missense_Mutation_p.S782A|FANCI_uc002bnn.1_RNA|FANCI_uc002bnp.1_Missense_Mutation_p.S603A|FANCI_uc002bnq.1_Missense_Mutation_p.S195A	NM_001113378	NP_001106849	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I isoform	782					cell cycle|DNA repair	nucleoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)												Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				---	---	---	---
WDR90	197335	broad.mit.edu	37	16	701703	701703	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:701703C>T	uc002cii.1	+	8	850	c.796C>T	c.(796-798)CGG>TGG	p.R266W	WDR90_uc002cig.1_Missense_Mutation_p.R266W|WDR90_uc002cih.1_Missense_Mutation_p.R266W|WDR90_uc002cij.1_RNA	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	266										ovary(1)	1		Hepatocellular(780;0.0218)																---	---	---	---
CCDC78	124093	broad.mit.edu	37	16	775066	775066	+	Intron	SNP	A	G	G			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:775066A>G	uc002cjg.2	-						CCDC78_uc002cjf.2_Intron|CCDC78_uc002cji.3_Silent_p.H295H|CCDC78_uc002cjj.3_Silent_p.H165H|CCDC78_uc002cjh.2_Intron|CCDC78_uc010uuo.1_Intron|CCDC78_uc002cjk.2_Silent_p.H210H|HAGHL_uc002cjl.1_5'Flank|HAGHL_uc002cjm.1_5'Flank|HAGHL_uc002cjn.1_5'Flank|HAGHL_uc002cjo.1_5'Flank|HAGHL_uc010uup.1_5'Flank	NM_001031737	NP_001026907			coiled-coil domain containing 78											central_nervous_system(1)	1		Hepatocellular(780;0.0218)																---	---	---	---
ATP2A1	487	broad.mit.edu	37	16	28909608	28909608	+	Silent	SNP	C	A	A			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:28909608C>A	uc002dro.1	+	14	1784	c.1600C>A	c.(1600-1602)CGG>AGG	p.R534R	uc010vct.1_Intron|ATP2A1_uc002drn.1_Silent_p.R534R|ATP2A1_uc002drp.1_Silent_p.R409R	NM_173201	NP_775293	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, fast twitch 1 isoform	534	Cytoplasmic (By similarity).				apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|ATP binding|calcium ion binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4																		---	---	---	---
CDH1	999	broad.mit.edu	37	16	68845623	68845623	+	Missense_Mutation	SNP	A	G	G			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:68845623A>G	uc002ewg.1	+	7	993	c.869A>G	c.(868-870)GAC>GGC	p.D290G	CDH1_uc010vlj.1_RNA|CDH1_uc010cfg.1_Missense_Mutation_p.D290G	NM_004360	NP_004351	P12830	CADH1_HUMAN	cadherin 1, type 1 preproprotein	290	Cadherin 2.|Extracellular (Potential).				adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding			breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)				Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer				---	---	---	---
INCA1	388324	broad.mit.edu	37	17	4891775	4891775	+	Silent	SNP	C	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:4891775C>T	uc002gaj.2	-	8	1088	c.636G>A	c.(634-636)TCG>TCA	p.S212S	CAMTA2_uc010cku.1_5'Flank|CAMTA2_uc002gag.1_5'Flank|CAMTA2_uc002gah.1_5'Flank|CAMTA2_uc002gai.1_5'Flank|CAMTA2_uc010vsu.1_5'Flank|INCA1_uc002gak.2_Silent_p.S212S|INCA1_uc002gal.2_Silent_p.S197S|INCA1_uc002gam.2_Silent_p.S197S	NM_213726	NP_998891	Q0VD86	INCA1_HUMAN	inhibitor of CDK, cyclin A1 interacting protein	212						nucleus					0																		---	---	---	---
TP53	7157	broad.mit.edu	37	17	7578407	7578407	+	Missense_Mutation	SNP	G	C	C	rs138729528		TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7578407G>C	uc002gim.2	-	5	717	c.523C>G	c.(523-525)CGC>GGC	p.R175G	TP53_uc002gig.1_Missense_Mutation_p.R175G|TP53_uc002gih.2_Missense_Mutation_p.R175G|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R43G|TP53_uc010cng.1_Missense_Mutation_p.R43G|TP53_uc002gii.1_Missense_Mutation_p.R43G|TP53_uc010cnh.1_Missense_Mutation_p.R175G|TP53_uc010cni.1_Missense_Mutation_p.R175G|TP53_uc002gij.2_Missense_Mutation_p.R175G|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R82G|TP53_uc002gio.2_Missense_Mutation_p.R43G|TP53_uc010vug.1_Missense_Mutation_p.R136G	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	175	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R175H(721)|p.R175L(19)|p.R175C(12)|p.R175G(11)|p.0?(7)|p.R175P(5)|p.R175S(5)|p.R175R(4)|p.R174fs*24(3)|p.R175_E180delRCPHHE(3)|p.R175fs*5(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V173fs*69(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R175fs*6(1)|p.R42fs*24(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R175fs*72(1)|p.R174fs*70(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.S149fs*72(1)|p.R174_E180>K(1)|p.R174fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)			111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---	---
MFSD6L	162387	broad.mit.edu	37	17	8701689	8701689	+	Missense_Mutation	SNP	C	G	G			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:8701689C>G	uc002glp.1	-	1	898	c.750G>C	c.(748-750)TTG>TTC	p.L250F		NM_152599	NP_689812	Q8IWD5	MFS6L_HUMAN	major facilitator superfamily domain containing	250	Helical; (Potential).					integral to membrane				central_nervous_system(1)	1																		---	---	---	---
MYH13	8735	broad.mit.edu	37	17	10219280	10219280	+	Silent	SNP	G	A	A			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:10219280G>A	uc002gmk.1	-	28	3891	c.3801C>T	c.(3799-3801)GAC>GAT	p.D1267D		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1267	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6																		---	---	---	---
ZNF286A	57335	broad.mit.edu	37	17	15604534	15604534	+	Missense_Mutation	SNP	C	T	T	rs145330416	byFrequency	TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:15604534C>T	uc010cot.2	+	3	502	c.106C>T	c.(106-108)CGC>TGC	p.R36C	ZNF286A_uc002goz.3_5'UTR|ZNF286A_uc010vwa.1_Missense_Mutation_p.R36C|ZNF286A_uc002gpa.2_Missense_Mutation_p.R36C	NM_001130842	NP_001124314	Q9HBT8	Z286A_HUMAN	zinc finger protein 286	36					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)|READ - Rectum adenocarcinoma(1115;0.0222)|BRCA - Breast invasive adenocarcinoma(8;0.0781)														---	---	---	---
ACCN1	40	broad.mit.edu	37	17	32483077	32483077	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:32483077G>A	uc002hhu.2	-	1	749	c.475C>T	c.(475-477)CGT>TGT	p.R159C		NM_001094	NP_001085	Q16515	ACCN1_HUMAN	amiloride-sensitive cation channel 1, neuronal	159	Extracellular (By similarity).				central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Breast(31;0.042)|Ovarian(249;0.202)		UCEC - Uterine corpus endometrioid carcinoma (308;0.13)|BRCA - Breast invasive adenocarcinoma(366;0.215)	Amiloride(DB00594)													---	---	---	---
CDC6	990	broad.mit.edu	37	17	38447833	38447833	+	Nonsense_Mutation	SNP	T	A	A			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:38447833T>A	uc002huj.1	+	4	783	c.573T>A	c.(571-573)TGT>TGA	p.C191*		NM_001254	NP_001245	Q99741	CDC6_HUMAN	cell division cycle 6 protein	191					cell division|DNA replication|DNA replication checkpoint|M/G1 transition of mitotic cell cycle|mitosis|negative regulation of cell proliferation|negative regulation of DNA replication|positive regulation of cell cycle cytokinesis|positive regulation of chromosome segregation|regulation of cyclin-dependent protein kinase activity|regulation of mitotic anaphase|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|traversing start control point of mitotic cell cycle	cytosol|nucleoplasm|spindle midzone|spindle pole	ATP binding|kinase binding|nucleoside-triphosphatase activity			ovary(2)|breast(1)	3																		---	---	---	---
ANKRD40	91369	broad.mit.edu	37	17	48776919	48776919	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:48776919G>A	uc002iso.2	-	3	874	c.619C>T	c.(619-621)CCT>TCT	p.P207S		NM_052855	NP_443087	Q6AI12	ANR40_HUMAN	ankyrin repeat domain 40	207	Pro-rich.										0			BRCA - Breast invasive adenocarcinoma(22;2.03e-09)															---	---	---	---
LAMA1	284217	broad.mit.edu	37	18	7080074	7080074	+	Missense_Mutation	SNP	A	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:7080074A>T	uc002knm.2	-	3	339	c.245T>A	c.(244-246)ATA>AAA	p.I82K	LAMA1_uc010wzj.1_5'UTR	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	82	Laminin N-terminal.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
KIAA1012	22878	broad.mit.edu	37	18	29435730	29435730	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:29435730G>A	uc002kxc.3	-	21	3593	c.3229C>T	c.(3229-3231)CGG>TGG	p.R1077W	KIAA1012_uc002kxb.3_Missense_Mutation_p.R1023W|KIAA1012_uc002kxd.3_RNA	NM_014939	NP_055754	Q9Y2L5	TPPC8_HUMAN	hypothetical protein LOC22878	1077					ER to Golgi vesicle-mediated transport	cis-Golgi network					0																		---	---	---	---
DSEL	92126	broad.mit.edu	37	18	65180164	65180164	+	Missense_Mutation	SNP	G	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:65180164G>T	uc002lke.1	-	2	2936	c.1712C>A	c.(1711-1713)TCT>TAT	p.S571Y		NM_032160	NP_115536	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	561						integral to membrane	isomerase activity|sulfotransferase activity			ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	6		Esophageal squamous(42;0.129)																---	---	---	---
ZNF236	7776	broad.mit.edu	37	18	74607109	74607109	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:74607109G>A	uc002lmi.2	+	10	1750	c.1552G>A	c.(1552-1554)GCC>ACC	p.A518T	ZNF236_uc002lmj.2_RNA	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	518	C2H2-type 11.				cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)														---	---	---	---
MED16	10025	broad.mit.edu	37	19	881554	881554	+	Intron	SNP	C	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:881554C>T	uc002lqd.1	-						MED16_uc010drw.1_Intron|MED16_uc002lqe.2_Intron|MED16_uc002lqf.2_Intron|MED16_uc010xfv.1_Intron|MED16_uc010xfw.1_Intron|MED16_uc010xfx.1_Intron|MED16_uc010xfy.1_Intron	NM_005481	NP_005472			mediator complex subunit 16						androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
ABCA7	10347	broad.mit.edu	37	19	1042830	1042830	+	Intron	SNP	G	A	A	rs113465431		TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:1042830G>A	uc002lqw.3	+						ABCA7_uc010dsb.1_Intron	NM_019112	NP_061985			ATP-binding cassette, sub-family A, member 7						phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			pancreas(7)|ovary(1)|central_nervous_system(1)	9		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
ZNF557	79230	broad.mit.edu	37	19	7081985	7081985	+	Silent	SNP	G	A	A			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:7081985G>A	uc002mgb.2	+	7	812	c.327G>A	c.(325-327)GTG>GTA	p.V109V	ZNF557_uc002mga.2_Silent_p.V116V|ZNF557_uc002mgc.2_Silent_p.V116V	NM_001044388	NP_001037853	Q8N988	ZN557_HUMAN	zinc finger protein 557 isoform b	109					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2				Lung(535;0.179)														---	---	---	---
ZNF317	57693	broad.mit.edu	37	19	9271728	9271728	+	Silent	SNP	G	A	A			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9271728G>A	uc002mku.2	+	7	1682	c.1407G>A	c.(1405-1407)ACG>ACA	p.T469T	ZNF317_uc002mkv.2_Silent_p.T328T|ZNF317_uc002mkw.2_Silent_p.T437T|ZNF317_uc002mkx.2_Silent_p.T384T|ZNF317_uc002mky.2_Silent_p.T352T	NM_020933	NP_065984	Q96PQ6	ZN317_HUMAN	zinc finger protein 317	469					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
SLC1A6	6511	broad.mit.edu	37	19	15063868	15063868	+	Silent	SNP	C	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:15063868C>T	uc002naa.1	-	8	1379	c.1371G>A	c.(1369-1371)ACG>ACA	p.T457T	SLC1A6_uc010dzu.1_Silent_p.T379T|SLC1A6_uc010xod.1_Silent_p.T393T	NM_005071	NP_005062	P48664	EAA4_HUMAN	solute carrier family 1 (high affinity	457					synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			pancreas(3)|ovary(2)|skin(1)	6					L-Glutamic Acid(DB00142)													---	---	---	---
ZNF599	148103	broad.mit.edu	37	19	35251150	35251150	+	Missense_Mutation	SNP	G	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:35251150G>T	uc010edn.1	-	4	944	c.556C>A	c.(556-558)CCA>ACA	p.P186T	ZNF599_uc010edm.1_Missense_Mutation_p.P149T	NM_001007248	NP_001007249	Q96NL3	ZN599_HUMAN	zinc finger protein 599	186					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)															---	---	---	---
ZNF345	25850	broad.mit.edu	37	19	37368633	37368633	+	Missense_Mutation	SNP	C	A	A			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:37368633C>A	uc002oex.2	+	3	1279	c.901C>A	c.(901-903)CTC>ATC	p.L301I	ZNF345_uc002oey.3_Missense_Mutation_p.L301I|ZNF345_uc002oez.2_Intron	NM_003419	NP_003410	Q14585	ZN345_HUMAN	zinc finger protein 345	301	C2H2-type 9.				negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)															---	---	---	---
HIPK4	147746	broad.mit.edu	37	19	40886895	40886895	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:40886895G>A	uc002onp.2	-	3	1288	c.1003C>T	c.(1003-1005)CGC>TGC	p.R335C		NM_144685	NP_653286	Q8NE63	HIPK4_HUMAN	homeodomain interacting protein kinase 4	335	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2			Lung(22;4.95e-05)|LUSC - Lung squamous cell carcinoma(20;0.000292)															---	---	---	---
SCAF1	58506	broad.mit.edu	37	19	50149863	50149863	+	Silent	SNP	C	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50149863C>T	uc002poq.2	+	5	466	c.342C>T	c.(340-342)CGC>CGT	p.R114R		NM_021228	NP_067051	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	114					mRNA processing|RNA splicing	nucleus	RNA binding				0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)														---	---	---	---
ZNF582	147948	broad.mit.edu	37	19	56901826	56901826	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:56901826T>G	uc002qmz.1	-	3	213	c.54A>C	c.(52-54)GAA>GAC	p.E18D	ZNF582_uc002qmy.2_Missense_Mutation_p.E49D	NM_144690	NP_653291	Q96NG8	ZN582_HUMAN	zinc finger protein 582	18	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|large_intestine(1)	4		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0547)														---	---	---	---
ZNF416	55659	broad.mit.edu	37	19	58083815	58083815	+	Missense_Mutation	SNP	C	A	A			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58083815C>A	uc002qpf.2	-	4	1628	c.1457G>T	c.(1456-1458)AGA>ATA	p.R486I	ZNF547_uc002qpm.3_Intron	NM_017879	NP_060349	Q9BWM5	ZN416_HUMAN	zinc finger protein 416	486	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0259)														---	---	---	---
TASP1	55617	broad.mit.edu	37	20	13415717	13415717	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:13415717G>A	uc002woi.2	-	12	1187	c.1070C>T	c.(1069-1071)TCC>TTC	p.S357F	TASP1_uc010zri.1_RNA|TASP1_uc002woh.2_Missense_Mutation_p.S334F	NM_017714	NP_060184	Q9H6P5	TASP1_HUMAN	taspase 1 precursor	357				S -> F (in Ref. 1; BAA91018).	asparagine catabolic process via L-aspartate|positive regulation of transcription, DNA-dependent|protein maturation		threonine-type endopeptidase activity				0																		---	---	---	---
DNMT3B	1789	broad.mit.edu	37	20	31394056	31394056	+	Silent	SNP	C	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:31394056C>T	uc002wyc.2	+	22	2664	c.2343C>T	c.(2341-2343)ATC>ATT	p.I781I	DNMT3B_uc002wyd.2_Silent_p.I761I|DNMT3B_uc002wye.2_Intron|DNMT3B_uc010gee.2_RNA|DNMT3B_uc010gef.2_Intron|DNMT3B_uc010ztz.1_Intron|DNMT3B_uc010zua.1_Intron|DNMT3B_uc002wyf.2_Silent_p.I773I|DNMT3B_uc002wyg.2_Intron|DNMT3B_uc010geg.2_Intron|DNMT3B_uc010geh.2_RNA	NM_006892	NP_008823	Q9UBC3	DNM3B_HUMAN	DNA cytosine-5 methyltransferase 3 beta isoform	781					negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			lung(3)|ovary(2)	5																		---	---	---	---
C20orf152	140894	broad.mit.edu	37	20	34563887	34563887	+	Missense_Mutation	SNP	G	A	A	rs138922540		TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:34563887G>A	uc002xes.1	+	3	362	c.206G>A	c.(205-207)CGA>CAA	p.R69Q	C20orf152_uc002xer.1_Missense_Mutation_p.R69Q|C20orf152_uc010gfp.1_RNA			Q96M20	CT152_HUMAN	SubName: Full=C20orf152 protein;	69											0	Breast(12;0.00631)																	---	---	---	---
COL6A2	1292	broad.mit.edu	37	21	47549167	47549167	+	Intron	SNP	C	T	T	rs148646436	byFrequency	TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:47549167C>T	uc002zia.1	+						COL6A2_uc002zhy.1_3'UTR|COL6A2_uc002zhz.1_Missense_Mutation_p.P840L|COL6A2_uc002zib.1_Intron|COL6A2_uc002zic.1_Intron|COL6A2_uc010gqe.1_5'Flank	NM_001849	NP_001840			alpha 2 type VI collagen isoform 2C2 precursor						axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)														---	---	---	---
FAM19A5	25817	broad.mit.edu	37	22	49042406	49042406	+	Intron	SNP	C	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:49042406C>T	uc003bim.3	+						FAM19A5_uc003bio.3_Intron	NM_001082967	NP_001076436			family with sequence similarity 19 (chemokine							extracellular region|integral to membrane				large_intestine(1)	1		all_cancers(38;2.95e-11)|all_epithelial(38;3.07e-10)|all_lung(38;2.89e-05)|Breast(42;0.000396)|Lung NSC(38;0.000471)|Ovarian(80;0.00934)|Lung SC(80;0.195)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0227)|BRCA - Breast invasive adenocarcinoma(115;0.119)														---	---	---	---
ZMYM3	9203	broad.mit.edu	37	X	70462830	70462830	+	Silent	SNP	G	A	A			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:70462830G>A	uc004dzh.1	-	22	3624	c.3537C>T	c.(3535-3537)CTC>CTT	p.L1179L	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Silent_p.L1179L|ZMYM3_uc004dzj.1_Silent_p.L1167L	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	1179					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)																	---	---	---	---
PABPC5	140886	broad.mit.edu	37	X	90690785	90690785	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:90690785C>T	uc004efg.2	+	2	649	c.209C>T	c.(208-210)GCG>GTG	p.A70V	PABPC5_uc004eff.1_Intron	NM_080832	NP_543022	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	70	RRM 1.					cytoplasm	nucleotide binding|RNA binding			ovary(1)|lung(1)|pancreas(1)	3																		---	---	---	---
PCDH11X	27328	broad.mit.edu	37	X	91873417	91873417	+	Silent	SNP	C	T	T			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:91873417C>T	uc004efk.1	+	7	4367	c.3522C>T	c.(3520-3522)AGC>AGT	p.S1174S	PCDH11X_uc004efl.1_Silent_p.S1164S|PCDH11X_uc004efo.1_Silent_p.S1137S|PCDH11X_uc010nmv.1_3'UTR|PCDH11X_uc004efm.1_Silent_p.S1166S|PCDH11X_uc004efn.1_Silent_p.S1156S	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	1174	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2																		---	---	---	---
AFF2	2334	broad.mit.edu	37	X	148048538	148048538	+	Silent	SNP	C	G	G			TCGA-D7-6518-01	TCGA-D7-6518-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:148048538C>G	uc004fcp.2	+	14	3611	c.3132C>G	c.(3130-3132)TCC>TCG	p.S1044S	AFF2_uc004fcq.2_Silent_p.S1034S|AFF2_uc004fcr.2_Silent_p.S1005S|AFF2_uc011mxb.1_Silent_p.S1009S|AFF2_uc004fcs.2_Silent_p.S1009S|AFF2_uc011mxc.1_Silent_p.S685S	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	1044					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
