Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_status	validation_method	validation_tumor_sample	validation_alt_allele
UBR4	23352	broad.mit.edu	37	1	19474752	19474752	+	Intron	DEL	A	-	-			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:19474752delA	uc001bbi.2	-						UBR4_uc001bbk.1_Intron	NM_020765	NP_065816			retinoblastoma-associated factor 600						interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)														---	---	---	---
ABCD3	5825	broad.mit.edu	37	1	94883978	94883980	+	5'UTR	DEL	GCC	-	-			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:94883978_94883980delGCC	uc001dqn.3	+	1					ABCD3_uc001dqm.3_5'UTR|ABCD3_uc010oto.1_5'UTR|ABCD3_uc010otp.1_5'UTR|ABCD3_uc009wdr.2_5'UTR	NM_002858	NP_002849			ATP-binding cassette, sub-family D, member 3						peroxisomal long-chain fatty acid import|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(1)	1		all_lung(203;0.000434)|Lung NSC(277;0.0019)		all cancers(265;0.0261)|Epithelial(280;0.165)														---	---	---	---
Unknown	0	broad.mit.edu	37	1	101721831	101721834	+	IGR	DEL	AAAG	-	-	rs71084874		TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:101721831_101721834delAAAG								S1PR1 (14755 upstream) : OLFM3 (546293 downstream)																																			---	---	---	---
NBPF9	400818	broad.mit.edu	37	1	144597983	144597991	+	Intron	DEL	CAGATAGAC	-	-	rs111294330		TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:144597983_144597991delCAGATAGAC	uc010oxr.1	+						NBPF9_uc010oxn.1_Intron|NBPF9_uc010oxo.1_Intron|NBPF9_uc010oxt.1_Intron|NBPF9_uc001ekg.1_Intron|NBPF9_uc001ekk.1_Intron|NBPF10_uc009wir.2_Intron|NBPF9_uc010oyd.1_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc009wif.1_Intron|uc001ele.2_Intron	NM_001037675	NP_001032764			hypothetical protein LOC400818							cytoplasm					0																		---	---	---	---
PDE4DIP	9659	broad.mit.edu	37	1	144853333	144853334	+	Intron	INS	-	AA	AA	rs149112816		TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:144853333_144853334insAA	uc001elw.3	-						NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Intron|PDE4DIP_uc001elv.3_Intron	NM_014644	NP_055459			phosphodiesterase 4D interacting protein isoform						cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)				T	PDGFRB	MPD								---	---	---	---
GAS5	60674	broad.mit.edu	37	1	173836247	173836248	+	RNA	INS	-	A	A	rs145452199	by1000genomes	TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:173836247_173836248insA	uc001gji.2	-	1		c.1_2insT			GAS5_uc001gjj.2_Intron|GAS5_uc001gjk.2_Intron|SNORD81_uc009wwi.1_5'Flank|SNORD47_uc001gjl.2_5'Flank|SNORD80_uc009wwj.1_5'Flank|SNORD79_uc009wwk.1_5'Flank|SNORD78_uc009wwl.2_5'Flank|SNORD44_uc001gjn.1_5'Flank|SNORD77_uc009wwm.1_5'Flank|SNORD76_uc009wwn.1_5'Flank|SNORD75_uc009wwo.1_5'Flank|ZBTB37_uc001gjp.1_5'Flank|ZBTB37_uc001gjq.3_5'Flank|ZBTB37_uc009wwp.1_5'Flank|ZBTB37_uc001gjr.2_5'Flank					Homo sapiens mRNA; cDNA DKFZp564D0164 (from clone DKFZp564D0164).												0																		---	---	---	---
Unknown	0	broad.mit.edu	37	1	219745880	219745883	+	IGR	DEL	AGGA	-	-			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:219745880_219745883delAGGA								LYPLAL1 (359674 upstream) : SLC30A10 (112886 downstream)																																			---	---	---	---
KIF26B	55083	broad.mit.edu	37	1	245775406	245775409	+	Intron	DEL	GTGA	-	-	rs28368385	by1000genomes	TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:245775406_245775409delGTGA	uc001ibf.1	+						KIF26B_uc010pyq.1_Intron|KIF26B_uc001ibg.1_Intron	NM_018012	NP_060482			kinesin family member 26B						microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)															---	---	---	---
RGPD1	400966	broad.mit.edu	37	2	87204958	87204958	+	Intron	DEL	T	-	-			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:87204958delT	uc010fgv.2	+						RMND5A_uc002srs.3_Intron|RGPD1_uc002ssb.2_Intron|RGPD1_uc002ssc.2_Intron	NM_001024457	NP_001019628			RANBP2-like and GRIP domain containing 1						intracellular transport		binding				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	2	121298811	121298812	+	IGR	INS	-	T	T			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:121298811_121298812insT								LOC84931 (74886 upstream) : GLI2 (194387 downstream)																																			---	---	---	---
CHRNG	1146	broad.mit.edu	37	2	233408187	233408188	+	Intron	INS	-	CCC	CCC			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:233408187_233408188insCCC	uc002vsx.1	+						CHRNG_uc010fye.1_Intron	NM_005199	NP_005190			cholinergic receptor, nicotinic, gamma						muscle contraction	cell junction|postsynaptic membrane	acetylcholine receptor activity				0		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;6.39e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00079)|LUSC - Lung squamous cell carcinoma(224;0.00757)|Lung(119;0.0086)														---	---	---	---
ATR	545	broad.mit.edu	37	3	142217728	142217728	+	Intron	DEL	T	-	-			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:142217728delT	uc003eux.3	-							NM_001184	NP_001175			ataxia telangiectasia and Rad3 related protein						cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20													Other_conserved_DNA_damage_response_genes					---	---	---	---
Unknown	0	broad.mit.edu	37	3	180605395	180605395	+	IGR	DEL	T	-	-			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:180605395delT								CCDC39 (149733 upstream) : FXR1 (25057 downstream)																																			---	---	---	---
SLIT2	9353	broad.mit.edu	37	4	20619355	20619355	+	Intron	DEL	T	-	-			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:20619355delT	uc003gpr.1	+						SLIT2_uc003gps.1_Intron	NM_004787	NP_004778			slit homolog 2 precursor						apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11																		---	---	---	---
WDR19	57728	broad.mit.edu	37	4	39279671	39279672	+	Intron	INS	-	A	A			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:39279671_39279672insA	uc003gtv.2	+						WDR19_uc011byi.1_Intron	NM_025132	NP_079408			WD repeat domain 19						cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1																		---	---	---	---
ADH5	128	broad.mit.edu	37	4	99996377	99996377	+	Intron	DEL	T	-	-	rs112636325		TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:99996377delT	uc003hui.2	-						ADH5_uc003huk.1_3'UTR|ADH5_uc003huj.2_Intron	NM_000671	NP_000662			class III alcohol dehydrogenase, chi subunit						ethanol oxidation|response to redox state		alcohol dehydrogenase (NAD) activity|electron carrier activity|fatty acid binding|formaldehyde dehydrogenase activity|S-(hydroxymethyl)glutathione dehydrogenase activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;2.5e-07)	NADH(DB00157)													---	---	---	---
RGNEF	64283	broad.mit.edu	37	5	73154250	73154251	+	Intron	INS	-	CTCA	CTCA	rs140928003	by1000genomes	TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:73154250_73154251insCTCA	uc011csq.1	+						RGNEF_uc003kcx.2_Intron|RGNEF_uc010izf.2_Intron|RGNEF_uc011csr.1_Intron	NM_001080479	NP_001073948			Rho-guanine nucleotide exchange factor						cell differentiation|intracellular signal transduction|regulation of Rho protein signal transduction	cytoplasm|plasma membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|RNA binding				0		Lung NSC(167;0.0378)|all_lung(232;0.04)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.25e-51)														---	---	---	---
CKMT2	1160	broad.mit.edu	37	5	80546759	80546760	+	Intron	INS	-	AC	AC	rs142418532	by1000genomes	TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:80546759_80546760insAC	uc003khc.3	+						RNU5E_uc011cto.1_Intron|CKMT2_uc010jaq.2_Intron|CKMT2_uc003khd.3_Intron|uc003khe.1_Intron|uc003khf.1_Intron|uc003khg.1_Intron	NM_001825	NP_001816			sarcomeric mitochondrial creatine kinase						creatine metabolic process|muscle contraction	mitochondrial inner membrane	ATP binding|creatine kinase activity				0		Lung NSC(167;0.00475)|all_lung(232;0.00502)|Ovarian(174;0.0336)		OV - Ovarian serous cystadenocarcinoma(54;2.29e-44)|Epithelial(54;1.05e-38)|all cancers(79;4.15e-34)	Creatine(DB00148)													---	---	---	---
SEMA6A	57556	broad.mit.edu	37	5	115822800	115822804	+	Intron	DEL	AAAAG	-	-	rs59861509		TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:115822800_115822804delAAAAG	uc010jck.2	-						SEMA6A_uc003krx.3_Intron	NM_020796	NP_065847			sema domain, transmembrane domain (TM), and						apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			ovary(2)	2		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)														---	---	---	---
GRIA1	2890	broad.mit.edu	37	5	153085222	153085223	+	Intron	INS	-	TT	TT	rs140530536		TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:153085222_153085223insTT	uc003lva.3	+						GRIA1_uc003luy.3_Intron|GRIA1_uc003luz.3_Intron|GRIA1_uc011dcv.1_Intron|GRIA1_uc011dcw.1_Intron|GRIA1_uc011dcx.1_Intron|GRIA1_uc011dcy.1_Intron|GRIA1_uc011dcz.1_Intron|GRIA1_uc010jia.1_Intron	NM_001114183	NP_001107655			glutamate receptor, ionotropic, AMPA 1 isoform						synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)													---	---	---	---
TTC1	7265	broad.mit.edu	37	5	159477985	159477985	+	Intron	DEL	T	-	-	rs67870845		TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:159477985delT	uc003lxu.2	+							NM_003314	NP_003305			tetratricopeptide repeat domain 1						protein folding		unfolded protein binding			skin(1)	1	Renal(175;0.00196)	all_hematologic(541;0.00014)|Breast(839;0.0101)|all_neural(177;0.0281)|Medulloblastoma(196;0.0425)|Lung NSC(249;0.119)|all_lung(500;0.163)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	Epithelial(171;8.37e-05)|all cancers(165;0.000694)|OV - Ovarian serous cystadenocarcinoma(192;0.0402)														---	---	---	---
Unknown	0	broad.mit.edu	37	6	139094629	139094630	+	Intron	INS	-	G	G	rs143951524	by1000genomes	TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:139094629_139094630insG	uc003qid.1	-						CCDC28A_uc003qie.2_5'Flank					Homo sapiens cDNA FLJ35273 fis, clone PROST2006020.																														---	---	---	---
LOC729156	729156	broad.mit.edu	37	7	66304731	66304731	+	Intron	DEL	T	-	-			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:66304731delT	uc003tvj.1	-							NR_003934				Homo sapiens cDNA FLJ36054 fis, clone TESTI2018290.												0																		---	---	---	---
TAF6	6878	broad.mit.edu	37	7	99710906	99710906	+	Intron	DEL	A	-	-	rs75828513		TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99710906delA	uc003uti.2	-						TAF6_uc003utg.2_Intron|TAF6_uc003uth.2_Intron|TAF6_uc003utk.2_Intron|TAF6_uc011kji.1_Intron|TAF6_uc003utj.2_Intron|TAF6_uc003utl.2_Intron|TAF6_uc003utm.2_Intron|TAF6_uc003utn.1_Intron	NM_139315	NP_647476			TBP-associated factor 6 isoform alpha						negative regulation of cell cycle|negative regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)																	---	---	---	---
ZAN	7455	broad.mit.edu	37	7	100388502	100388503	+	Intron	DEL	AA	-	-			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100388502_100388503delAA	uc003uwj.2	+						ZAN_uc003uwk.2_Intron|ZAN_uc003uwl.2_Intron|ZAN_uc010lhh.2_Intron|ZAN_uc010lhi.2_Intron|ZAN_uc011kke.1_Intron	NM_003386	NP_003377			zonadhesin isoform 3						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)															---	---	---	---
STC1	6781	broad.mit.edu	37	8	23709570	23709571	+	Intron	DEL	TG	-	-	rs113294965		TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:23709570_23709571delTG	uc003xdw.1	-							NM_003155	NP_003146			stanniocalcin 1 precursor						cell surface receptor linked signaling pathway|cell-cell signaling|cellular calcium ion homeostasis		hormone activity			skin(3)|upper_aerodigestive_tract(1)	4		Prostate(55;0.055)|Breast(100;0.116)		Colorectal(74;0.0155)|COAD - Colon adenocarcinoma(73;0.0632)														---	---	---	---
NKAIN3	286183	broad.mit.edu	37	8	63502435	63502448	+	Intron	DEL	TGTGTGTGTGTGTG	-	-	rs72423486		TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:63502435_63502448delTGTGTGTGTGTGTG	uc010lyq.1	+							NM_173688	NP_775959			Na+/K+ transporting ATPase interacting 3							integral to membrane|plasma membrane					0	Breast(64;0.127)	Lung NSC(129;0.187)																---	---	---	---
Unknown	0	broad.mit.edu	37	8	142723793	142723795	+	IGR	DEL	TGG	-	-			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:142723793_142723795delTGG								FLJ43860 (206463 upstream) : MIR1302-7 (143808 downstream)																																			---	---	---	---
MLLT3	4300	broad.mit.edu	37	9	20448401	20448401	+	Intron	DEL	A	-	-			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:20448401delA	uc003zoe.2	-						MLLT3_uc011lne.1_Intron|MLLT3_uc011lnf.1_Intron|MLLT3_uc003zof.2_Intron|MLLT3_uc011lng.1_Intron	NM_004529	NP_004520			myeloid/lymphoid or mixed-lineage leukemia						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)				T	MLL	ALL								---	---	---	---
ANKRD20A4	728747	broad.mit.edu	37	9	69420250	69420251	+	Intron	INS	-	CTTA	CTTA			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:69420250_69420251insCTTA	uc004afn.2	+							NM_001098805	NP_001092275			ankyrin repeat domain 20 family, member A4												0																		---	---	---	---
MRC1	4360	broad.mit.edu	37	10	17875520	17875521	+	Intron	DEL	AA	-	-			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:17875520_17875521delAA	uc001ipk.2	+							NM_002438	NP_002429			mannose receptor C type 1 precursor						receptor-mediated endocytosis	endosome membrane|integral to plasma membrane	mannose binding|receptor activity				0																		---	---	---	---
CYP26C1	340665	broad.mit.edu	37	10	94826082	94826088	+	Intron	DEL	CCTGCCG	-	-	rs61863115	by1000genomes	TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:94826082_94826088delCCTGCCG	uc010qns.1	+						CYP26C1_uc009xud.2_Intron	NM_183374	NP_899230			cytochrome P450, family 26, subfamily C,						anterior/posterior pattern formation|central nervous system development|negative regulation of retinoic acid receptor signaling pathway|neural crest cell development|organelle fusion|retinoic acid catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			central_nervous_system(1)	1		Colorectal(252;0.122)																---	---	---	---
SORBS1	10580	broad.mit.edu	37	10	97131604	97131604	+	Intron	DEL	A	-	-			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:97131604delA	uc001kkp.2	-						SORBS1_uc001kkk.2_Intron|SORBS1_uc001kkl.2_Intron|SORBS1_uc001kkn.2_Intron|SORBS1_uc001kkm.2_Intron|SORBS1_uc001kko.2_Intron|SORBS1_uc001kkq.2_Intron|SORBS1_uc001kkr.2_Intron|SORBS1_uc001kks.2_Intron|SORBS1_uc001kkt.2_Intron|SORBS1_uc001kku.2_Intron|SORBS1_uc001kkv.2_Intron|SORBS1_uc001kkw.2_Intron|SORBS1_uc010qoe.1_Intron|SORBS1_uc010qof.1_Intron	NM_001034954	NP_001030126			sorbin and SH3 domain containing 1 isoform 3						focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			breast(1)	1		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)														---	---	---	---
Unknown	0	broad.mit.edu	37	10	115745808	115745808	+	IGR	DEL	G	-	-			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:115745808delG								NHLRC2 (77356 upstream) : ADRB1 (57998 downstream)																																			---	---	---	---
SLC22A20	440044	broad.mit.edu	37	11	64997532	64997532	+	Intron	DEL	T	-	-	rs150430504	by1000genomes	TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:64997532delT	uc010roc.1	+							NM_001004326	NP_001004326			solute carrier family 22, member 20						ion transport	integral to membrane	transmembrane transporter activity			central_nervous_system(1)	1																		---	---	---	---
PDE1B	5153	broad.mit.edu	37	12	54967640	54967641	+	Intron	INS	-	GAGA	GAGA	rs142403478	by1000genomes	TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:54967640_54967641insGAGA	uc001sgd.1	+						PDE1B_uc010soz.1_Intron|PDE1B_uc010spa.1_Intron|PDE1B_uc001sgf.2_Intron|PDE1B_uc001sge.2_Intron|PDE1B_uc009znq.2_Intron	NM_000924	NP_000915			phosphodiesterase 1B isoform 1						activation of phospholipase C activity|apoptosis|nerve growth factor receptor signaling pathway|platelet activation	cytosol|nucleus	3',5'-cyclic-AMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			upper_aerodigestive_tract(1)|ovary(1)	2																		---	---	---	---
KIF5A	3798	broad.mit.edu	37	12	57975862	57975862	+	Intron	DEL	A	-	-			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57975862delA	uc001sor.1	+						KIF5A_uc010srr.1_Intron|uc001sos.2_5'Flank	NM_004984	NP_004975			kinesin family member 5A						blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			ovary(2)|skin(1)	3																		---	---	---	---
TBC1D15	64786	broad.mit.edu	37	12	72286900	72286901	+	Intron	INS	-	T	T			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:72286900_72286901insT	uc001swu.2	+						TBC1D15_uc009zrv.2_Intron|TBC1D15_uc010stt.1_Intron|TBC1D15_uc001swv.2_Intron|TBC1D15_uc001sww.2_Intron	NM_022771	NP_073608			TBC1 domain family, member 15 isoform 1								protein binding|Rab GTPase activator activity				0																		---	---	---	---
NT5DC3	51559	broad.mit.edu	37	12	104187930	104187930	+	Intron	DEL	T	-	-			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:104187930delT	uc010swe.1	-							NM_001031701	NP_001026871			5'-nucleotidase domain containing 3								hydrolase activity|metal ion binding			ovary(2)|skin(1)	3																		---	---	---	---
Unknown	0	broad.mit.edu	37	12	119145415	119145416	+	IGR	INS	-	TGGTGA	TGGTGA	rs28483306		TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:119145415_119145416insTGGTGA								SUDS3 (289576 upstream) : SRRM4 (273980 downstream)																																			---	---	---	---
TPTE2P1	646405	broad.mit.edu	37	13	25527490	25527491	+	Intron	INS	-	AAAAAG	AAAAAG			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:25527490_25527491insAAAAAG	uc010tdh.1	-						TPTE2P1_uc001upx.3_Intron	NR_026730				RecName: Full=C2 tensin-type domain-containing protein ENSP00000371290;												0																		---	---	---	---
Unknown	0	broad.mit.edu	37	14	20086237	20086237	+	IGR	DEL	T	-	-			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:20086237delT								P704P (65965 upstream) : OR4Q3 (129350 downstream)																																			---	---	---	---
DMXL2	23312	broad.mit.edu	37	15	51783640	51783640	+	Intron	DEL	A	-	-			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:51783640delA	uc002abf.2	-						DMXL2_uc010ufy.1_Intron|DMXL2_uc010bfa.2_Intron	NM_015263	NP_056078			Dmx-like 2							cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)														---	---	---	---
TPSAB1	7177	broad.mit.edu	37	16	1291717	1291718	+	Intron	INS	-	G	G			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:1291717_1291718insG	uc002ckz.2	+						TPSAB1_uc010uux.1_Intron	NM_003294	NP_003285			tryptase alpha/beta 1 precursor						defense response|proteolysis	extracellular space	protein binding|serine-type endopeptidase activity				0		Hepatocellular(780;0.00369)																---	---	---	---
ATF7IP2	80063	broad.mit.edu	37	16	10532277	10532277	+	Intron	DEL	T	-	-			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:10532277delT	uc002czu.2	+						ATF7IP2_uc002czv.2_Intron|ATF7IP2_uc010uyo.1_Intron|ATF7IP2_uc010uyp.1_Intron|ATF7IP2_uc002czw.2_Intron|ATF7IP2_uc010uyq.1_Intron	NM_024997	NP_079273			activating transcription factor 7 interacting						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0																		---	---	---	---
Unknown	0	broad.mit.edu	37	16	21469994	21469994	+	Intron	DEL	A	-	-			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:21469994delA	uc002diq.3	+						LOC100271836_uc002diu.1_Intron|LOC100271836_uc002diz.1_5'Flank					Homo sapiens cDNA FLJ59829 complete cds.																														---	---	---	---
Unknown	0	broad.mit.edu	37	17	30330033	30330035	+	IGR	DEL	TTT	-	-	rs113984157		TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:30330033_30330035delTTT								SUZ12 (1976 upstream) : LRRC37B (5002 downstream)																																			---	---	---	---
NPEPPS	9520	broad.mit.edu	37	17	45679204	45679204	+	Intron	DEL	A	-	-			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:45679204delA	uc002ilr.3	+						NPEPPS_uc010wkt.1_Intron|NPEPPS_uc010wku.1_Intron|NPEPPS_uc010wkv.1_Intron|NPEPPS_uc002ils.1_5'Flank	NM_006310	NP_006301			aminopeptidase puromycin sensitive						proteolysis	cytosol|nucleus	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding				0																		---	---	---	---
TEX14	56155	broad.mit.edu	37	17	56690561	56690561	+	Intron	DEL	A	-	-	rs77849538		TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:56690561delA	uc010dcz.1	-						TEX14_uc002iwr.1_Intron|TEX14_uc002iws.1_Intron|TEX14_uc010dda.1_Intron	NM_198393	NP_938207			testis expressed sequence 14 isoform a							cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)																	---	---	---	---
Unknown	0	broad.mit.edu	37	17	62932555	62932556	+	IGR	DEL	GT	-	-	rs35142297		TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:62932555_62932556delGT								LRRC37A3 (16969 upstream) : AMZ2P1 (30112 downstream)																																			---	---	---	---
SAFB	6294	broad.mit.edu	37	19	5661897	5661897	+	Intron	DEL	T	-	-	rs72490613		TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:5661897delT	uc002mcf.2	+						SAFB_uc002mcg.2_Intron|SAFB_uc002mce.3_Intron|SAFB_uc010xir.1_Intron|SAFB_uc010xis.1_Intron|SAFB_uc010xit.1_Intron|SAFB_uc010xiu.1_Intron	NM_002967	NP_002958			scaffold attachment factor B						chromatin organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding			ovary(1)|liver(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;0.000222)														---	---	---	---
ZNF699	374879	broad.mit.edu	37	19	9408812	9408812	+	Intron	DEL	T	-	-	rs144670815		TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9408812delT	uc002mlc.1	-							NM_198535	NP_940937			zinc finger protein 699						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	19	50223451	50223451	+	IGR	DEL	T	-	-			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50223451delT								CPT1C (6463 upstream) : TSKS (19561 downstream)																																			---	---	---	---
NLRP2	55655	broad.mit.edu	37	19	55512434	55512438	+	3'UTR	DEL	CTTAT	-	-	rs4200	byFrequency	TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55512434_55512438delCTTAT	uc002qij.2	+	13					NLRP2_uc010yfp.1_3'UTR|NLRP2_uc010esn.2_3'UTR|NLRP2_uc010eso.2_3'UTR|NLRP2_uc010esp.2_3'UTR	NM_017852	NP_060322			NLR family, pyrin domain containing 2						apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)														---	---	---	---
BAGE2	85319	broad.mit.edu	37	21	11085863	11085864	+	Intron	INS	-	C	C			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:11085863_11085864insC	uc002yit.1	-						BAGE_uc002yix.2_Intron	NM_182482	NP_872288			B melanoma antigen family, member 2 precursor												0			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)														---	---	---	---
COL6A1	1291	broad.mit.edu	37	21	47407704	47407704	+	Intron	DEL	G	-	-	rs66929103		TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:47407704delG	uc002zhu.1	+							NM_001848	NP_001839			collagen, type VI, alpha 1 precursor						axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			ovary(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)													---	---	---	---
SLC16A2	6567	broad.mit.edu	37	X	73693298	73693299	+	Intron	DEL	TC	-	-			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:73693298_73693299delTC	uc004ebt.2	+							NM_006517	NP_006508			solute carrier family 16, member 2							integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity			breast(2)|ovary(1)	3					Pyruvic acid(DB00119)													---	---	---	---
C1orf51	148523	broad.mit.edu	37	1	150256881	150256881	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:150256881G>A	uc001euh.2	+	4	624	c.488G>A	c.(487-489)CGT>CAT	p.R163H	C1orf51_uc001eui.2_Missense_Mutation_p.R75H|C1orf51_uc001euj.2_Missense_Mutation_p.R163H	NM_144697	NP_653298	Q8N365	CA051_HUMAN	hypothetical protein LOC148523	163											0	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)															---	---	---	---
FCRL2	79368	broad.mit.edu	37	1	157737336	157737336	+	Intron	SNP	G	A	A			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:157737336G>A	uc001fre.2	-						FCRL2_uc001frd.2_Missense_Mutation_p.H30Y|FCRL2_uc010phz.1_Intron|FCRL2_uc009wsp.2_Intron	NM_030764	NP_110391			Fc receptor-like 2 precursor						cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			ovary(1)|pancreas(1)	2	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)															---	---	---	---
TNR	7143	broad.mit.edu	37	1	175355352	175355352	+	Silent	SNP	G	T	T			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:175355352G>T	uc001gkp.1	-	6	1674	c.1593C>A	c.(1591-1593)GTC>GTA	p.V531V	TNR_uc009wwu.1_Silent_p.V531V	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	531	Fibronectin type-III 3.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)																	---	---	---	---
FAM89A	375061	broad.mit.edu	37	1	231155737	231155737	+	Missense_Mutation	SNP	C	T	T	rs61740910	byFrequency	TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:231155737C>T	uc001hui.2	-	2	465	c.427G>A	c.(427-429)GAT>AAT	p.D143N	FAM89A_uc009xfm.2_Missense_Mutation_p.D154N|MIR1182_hsa-mir-1182|MI0006275_5'Flank	NM_198552	NP_940954	Q96GI7	FA89A_HUMAN	family with sequence similarity 89, member A	143											0	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)																---	---	---	---
B3GALNT2	148789	broad.mit.edu	37	1	235629002	235629002	+	Silent	SNP	G	A	A			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:235629002G>A	uc001hxc.2	-	7	1021	c.792C>T	c.(790-792)TTC>TTT	p.F264F	B3GALNT2_uc001hxd.1_Silent_p.F305F	NM_152490	NP_689703	Q8NCR0	B3GL2_HUMAN	beta-1,3-N-acetylgalactosaminyltransferase 2	264	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity			breast(1)	1	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.0539)|Prostate(94;0.0353)	OV - Ovarian serous cystadenocarcinoma(106;0.000117)															---	---	---	---
OR6F1	343169	broad.mit.edu	37	1	247875986	247875986	+	Missense_Mutation	SNP	C	A	A			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:247875986C>A	uc001idj.1	-	1	72	c.72G>T	c.(70-72)CAG>CAT	p.Q24H		NM_001005286	NP_001005286	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F,	24	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)															---	---	---	---
OR2M4	26245	broad.mit.edu	37	1	248402739	248402739	+	Missense_Mutation	SNP	G	T	T			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:248402739G>T	uc010pzh.1	+	1	509	c.509G>T	c.(508-510)AGC>ATC	p.S170I		NM_017504	NP_059974	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M,	170	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)															---	---	---	---
RASGRP3	25780	broad.mit.edu	37	2	33748980	33748980	+	Missense_Mutation	SNP	G	T	T			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:33748980G>T	uc002rox.2	+	9	1178	c.551G>T	c.(550-552)TGC>TTC	p.C184F	RASGRP3_uc010ync.1_Missense_Mutation_p.C184F|RASGRP3_uc002roy.2_Missense_Mutation_p.C184F	NM_170672	NP_733772	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and	184	Ras-GEF.				MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			lung(3)|ovary(1)|pancreas(1)	5	all_hematologic(175;0.115)																	---	---	---	---
DYSF	8291	broad.mit.edu	37	2	71744167	71744167	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:71744167C>T	uc002sie.2	+	9	1280	c.904C>T	c.(904-906)CGG>TGG	p.R302W	DYSF_uc010feg.2_Missense_Mutation_p.R333W|DYSF_uc010feh.2_Missense_Mutation_p.R302W|DYSF_uc002sig.3_Missense_Mutation_p.R302W|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.R302W|DYSF_uc010fef.2_Missense_Mutation_p.R333W|DYSF_uc010fei.2_Missense_Mutation_p.R333W|DYSF_uc010fek.2_Missense_Mutation_p.R334W|DYSF_uc010fej.2_Missense_Mutation_p.R303W|DYSF_uc010fel.2_Missense_Mutation_p.R303W|DYSF_uc010feo.2_Missense_Mutation_p.R334W|DYSF_uc010fem.2_Missense_Mutation_p.R303W|DYSF_uc010fen.2_Missense_Mutation_p.R334W|DYSF_uc002sif.2_Missense_Mutation_p.R303W	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	302	Cytoplasmic (Potential).|C2 2.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7																		---	---	---	---
CTNNA2	1496	broad.mit.edu	37	2	80101439	80101439	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:80101439G>A	uc010ysh.1	+	5	828	c.823G>A	c.(823-825)GAG>AAG	p.E275K	CTNNA2_uc010yse.1_Missense_Mutation_p.E275K|CTNNA2_uc010ysf.1_Missense_Mutation_p.E275K|CTNNA2_uc010ysg.1_Missense_Mutation_p.E275K	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	275					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9																		---	---	---	---
Unknown	0	broad.mit.edu	37	2	89416981	89416981	+	RNA	SNP	C	T	T			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:89416981C>T	uc010ytr.1	-	42		c.4621G>A			uc002stl.2_Intron					Parts of antibodies, mostly variable regions.																														---	---	---	---
TBC1D8	11138	broad.mit.edu	37	2	101624572	101624572	+	Missense_Mutation	SNP	C	A	A			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:101624572C>A	uc010fiv.2	-	20	3265	c.3134G>T	c.(3133-3135)GGG>GTG	p.G1045V	RPL31_uc010yvu.1_Intron|RPL31_uc010yvv.1_Intron|RPL31_uc010fiu.1_Intron|TBC1D8_uc002tau.3_Missense_Mutation_p.G802V	NM_001102426	NP_001095896	O95759	TBCD8_HUMAN	TBC1 domain family, member 8	1045					blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			ovary(3)	3																		---	---	---	---
BTD	686	broad.mit.edu	37	3	15686531	15686531	+	Missense_Mutation	SNP	G	T	T			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:15686531G>T	uc003cah.2	+	4	1271	c.1168G>T	c.(1168-1170)GCT>TCT	p.A390S	BTD_uc011avv.1_Missense_Mutation_p.A392S|BTD_uc011avw.1_Missense_Mutation_p.A392S|BTD_uc011avx.1_Missense_Mutation_p.A370S	NM_000060	NP_000051	P43251	BTD_HUMAN	biotinidase precursor	390					central nervous system development|epidermis development|nitrogen compound metabolic process	extracellular space	biotin carboxylase activity|biotinidase activity				0																		---	---	---	---
TGFBR2	7048	broad.mit.edu	37	3	30715667	30715667	+	Missense_Mutation	SNP	T	C	C			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:30715667T>C	uc003ceo.2	+	5	1707	c.1325T>C	c.(1324-1326)TTC>TCC	p.F442S	TGFBR2_uc003cen.2_Missense_Mutation_p.F467S	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II	442	Protein kinase.|Cytoplasmic (Potential).				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26																		---	---	---	---
RHOA	387	broad.mit.edu	37	3	49412898	49412898	+	Missense_Mutation	SNP	T	C	C			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49412898T>C	uc003cwu.2	-	2	401	c.125A>G	c.(124-126)TAT>TGT	p.Y42C	RHOA_uc010hku.2_5'UTR	NM_001664	NP_001655	P61586	RHOA_HUMAN	ras homolog gene family, member A precursor	42	Effector region (Potential).				axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)													---	---	---	---
TMEM108	66000	broad.mit.edu	37	3	133098617	133098617	+	Missense_Mutation	SNP	T	C	C			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:133098617T>C	uc003eph.2	+	4	336	c.62T>C	c.(61-63)CTG>CCG	p.L21P	TMEM108_uc003epi.2_Missense_Mutation_p.L21P|TMEM108_uc003epj.1_Missense_Mutation_p.L21P|TMEM108_uc003epk.2_Intron|TMEM108_uc003epm.2_5'UTR	NM_023943	NP_076432	Q6UXF1	TM108_HUMAN	transmembrane protein 108 precursor	21						integral to membrane				ovary(2)|skin(2)	4																		---	---	---	---
KIAA1211	57482	broad.mit.edu	37	4	57181091	57181091	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:57181091G>A	uc003hbk.2	+	8	1814	c.1423G>A	c.(1423-1425)GAT>AAT	p.D475N	KIAA1211_uc010iha.2_Missense_Mutation_p.D468N|KIAA1211_uc011bzz.1_Missense_Mutation_p.D385N|KIAA1211_uc003hbm.1_Missense_Mutation_p.D361N	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	475	Glu-rich.									ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)																	---	---	---	---
FGA	2243	broad.mit.edu	37	4	155506853	155506853	+	Silent	SNP	A	C	C			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:155506853A>C	uc003iod.1	-	5	1786	c.1728T>G	c.(1726-1728)TCT>TCG	p.S576S	FGA_uc003ioe.1_Silent_p.S576S|FGA_uc003iof.1_Intron	NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	576	By similarity.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)													---	---	---	---
MORF4	10934	broad.mit.edu	37	4	174537803	174537803	+	5'Flank	SNP	C	T	T			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:174537803C>T	uc011cke.1	-							NM_006792	NP_006783			mortality factor 4												0		Prostate(90;0.00201)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0765)|all_hematologic(60;0.107)		all cancers(43;1.88e-18)|Epithelial(43;1.19e-16)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-09)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)														---	---	---	---
ADAMTS16	170690	broad.mit.edu	37	5	5242289	5242289	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:5242289G>A	uc003jdl.2	+	17	2785	c.2647G>A	c.(2647-2649)GTG>ATG	p.V883M	ADAMTS16_uc003jdk.1_Missense_Mutation_p.V883M	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	883	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8																		---	---	---	---
PCDHB2	56133	broad.mit.edu	37	5	140474440	140474440	+	Missense_Mutation	SNP	G	T	T			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140474440G>T	uc003lil.2	+	1	204	c.66G>T	c.(64-66)TTG>TTT	p.L22F	PCDHB2_uc003lim.1_Intron	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	22					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)															---	---	---	---
C6orf201	404220	broad.mit.edu	37	6	4087935	4087935	+	Silent	SNP	C	T	T			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:4087935C>T	uc003mwa.3	+	2	828	c.60C>T	c.(58-60)CGC>CGT	p.R20R	C6orf146_uc010jnq.1_5'Flank|C6orf146_uc003mvy.2_5'Flank|C6orf201_uc003mvz.3_Intron|C6orf201_uc011dhw.1_Silent_p.R20R|C6orf201_uc003mwb.3_RNA	NM_001085401	NP_001078870	Q7Z4U5	CF201_HUMAN	hypothetical protein LOC404220	20											0	Ovarian(93;0.0925)	all_hematologic(90;0.0895)																---	---	---	---
SYNE1	23345	broad.mit.edu	37	6	152563476	152563476	+	Missense_Mutation	SNP	G	T	T			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:152563476G>T	uc010kiw.2	-	107	20394	c.19792C>A	c.(19792-19794)CTG>ATG	p.L6598M	SYNE1_uc010kiv.2_Missense_Mutation_p.L1122M|SYNE1_uc003qos.3_Missense_Mutation_p.L1122M|SYNE1_uc003qot.3_Missense_Mutation_p.L6527M|SYNE1_uc003qou.3_Missense_Mutation_p.L6598M	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6598	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)											HNSCC(10;0.0054)			---	---	---	---
GLI3	2737	broad.mit.edu	37	7	42011956	42011956	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:42011956C>T	uc011kbh.1	-	13	2174	c.2083G>A	c.(2083-2085)GTC>ATC	p.V695I	GLI3_uc011kbg.1_Missense_Mutation_p.V636I	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	695					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19														Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				---	---	---	---
ADAM22	53616	broad.mit.edu	37	7	87564386	87564386	+	Missense_Mutation	SNP	T	C	C			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:87564386T>C	uc003ujn.2	+	2	210	c.131T>C	c.(130-132)TTC>TCC	p.F44S	ADAM22_uc003uji.1_Missense_Mutation_p.F43S|ADAM22_uc003ujj.1_Missense_Mutation_p.F44S|ADAM22_uc003ujk.1_Missense_Mutation_p.F44S|ADAM22_uc003ujl.1_Missense_Mutation_p.F44S|ADAM22_uc003ujm.2_Missense_Mutation_p.F44S|ADAM22_uc003ujo.2_Missense_Mutation_p.F44S|ADAM22_uc003ujp.1_Missense_Mutation_p.F96S	NM_021723	NP_068369	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22 isoform 1	44					cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)															---	---	---	---
PTPRZ1	5803	broad.mit.edu	37	7	121652018	121652018	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:121652018A>C	uc003vjy.2	+	12	3313	c.2918A>C	c.(2917-2919)AAG>ACG	p.K973T	PTPRZ1_uc003vjz.2_Intron|PTPRZ1_uc011knt.1_Intron	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	973	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9																		---	---	---	---
DLGAP2	9228	broad.mit.edu	37	8	1513926	1513926	+	Silent	SNP	G	C	C			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:1513926G>C	uc003wpl.2	+	3	1165	c.1068G>C	c.(1066-1068)GGG>GGC	p.G356G	DLGAP2_uc003wpm.2_Silent_p.G356G	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	435					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)														---	---	---	---
BMP1	649	broad.mit.edu	37	8	22037329	22037329	+	Silent	SNP	T	C	C			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:22037329T>C	uc003xbg.2	+	7	1192	c.948T>C	c.(946-948)CTT>CTC	p.L316L	BMP1_uc003xba.2_Silent_p.L316L|BMP1_uc003xbb.2_Silent_p.L316L|BMP1_uc003xbe.2_RNA|BMP1_uc003xbc.2_Silent_p.L65L|BMP1_uc003xbd.2_RNA|BMP1_uc003xbf.2_Silent_p.L65L|BMP1_uc011kzc.1_Silent_p.L65L|BMP1_uc003xbh.2_RNA|BMP1_uc003xbi.2_RNA	NM_006129	NP_006120	P13497	BMP1_HUMAN	bone morphogenetic protein 1 isoform 3	316	Metalloprotease.				cartilage condensation|cell differentiation|lipid metabolic process|lipoprotein metabolic process|ossification|positive regulation of cartilage development|proteolysis	extracellular space	calcium ion binding|cytokine activity|growth factor activity|metalloendopeptidase activity|zinc ion binding			ovary(2)|breast(1)	3				Colorectal(74;0.00229)|COAD - Colon adenocarcinoma(73;0.0661)|READ - Rectum adenocarcinoma(644;0.11)														---	---	---	---
CTHRC1	115908	broad.mit.edu	37	8	104384809	104384809	+	Intron	SNP	C	T	T			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:104384809C>T	uc003ylk.2	+						CTHRC1_uc011lhq.1_Intron	NM_138455	NP_612464			collagen triple helix repeat containing 1							collagen				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(57;2.79e-06)|STAD - Stomach adenocarcinoma(118;0.197)															---	---	---	---
GTPBP4	23560	broad.mit.edu	37	10	1053033	1053033	+	Silent	SNP	C	T	T			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:1053033C>T	uc001ift.2	+	10	1149	c.1078C>T	c.(1078-1080)CTG>TTG	p.L360L	GTPBP4_uc010qac.1_Silent_p.L151L|GTPBP4_uc001ifu.2_RNA|GTPBP4_uc010qad.1_Silent_p.L244L|GTPBP4_uc010qae.1_Silent_p.L313L	NM_012341	NP_036473	Q9BZE4	NOG1_HUMAN	G protein-binding protein CRFG	360					negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of collagen binding|negative regulation of DNA replication|negative regulation of protein ubiquitination|protein stabilization|regulation of cyclin-dependent protein kinase activity|ribosome biogenesis	nucleolus|perinuclear region of cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)|skin(1)	2		all_epithelial(10;0.107)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.0814)	Epithelial(11;0.0513)|all cancers(11;0.135)|OV - Ovarian serous cystadenocarcinoma(14;0.173)														---	---	---	---
PRKG1	5592	broad.mit.edu	37	10	54041923	54041923	+	Missense_Mutation	SNP	G	C	C			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:54041923G>C	uc001jjm.2	+	14	1705	c.1511G>C	c.(1510-1512)GGC>GCC	p.G504A	PRKG1_uc001jjo.2_Missense_Mutation_p.G519A|PRKG1_uc009xow.1_Missense_Mutation_p.G222A|uc001jjq.1_Intron	NM_001098512	NP_001091982	Q13976	KGP1_HUMAN	protein kinase, cGMP-dependent, type I isoform	504	Protein kinase.				actin cytoskeleton organization|platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			lung(2)|stomach(1)|ovary(1)|central_nervous_system(1)|skin(1)	6		all_cancers(4;2.13e-08)|all_epithelial(4;2.44e-08)|all_lung(4;0.000173)		all cancers(4;1.18e-05)|GBM - Glioblastoma multiforme(4;0.000359)|Epithelial(53;0.00532)|Lung(62;0.0606)														---	---	---	---
BICC1	80114	broad.mit.edu	37	10	60588555	60588555	+	Silent	SNP	G	A	A			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:60588555G>A	uc001jki.1	+	21	2829	c.2829G>A	c.(2827-2829)TCG>TCA	p.S943S		NM_001080512	NP_001073981	Q9H694	BICC1_HUMAN	bicaudal C homolog 1	943					multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4																		---	---	---	---
MYPN	84665	broad.mit.edu	37	10	69961629	69961629	+	Missense_Mutation	SNP	G	T	T			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:69961629G>T	uc001jnm.3	+	19	3722	c.3537G>T	c.(3535-3537)CAG>CAT	p.Q1179H	MYPN_uc001jnn.3_Missense_Mutation_p.Q904H|MYPN_uc001jno.3_Missense_Mutation_p.Q1179H|MYPN_uc009xpt.2_Missense_Mutation_p.Q1179H|MYPN_uc010qit.1_Missense_Mutation_p.Q885H|MYPN_uc010qiu.1_RNA	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	1179	Interaction with ACTN.|Ig-like 5.					nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5																		---	---	---	---
C11orf35	256329	broad.mit.edu	37	11	557633	557633	+	Missense_Mutation	SNP	G	A	A	rs138095963		TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:557633G>A	uc001lpx.2	-	6	626	c.563C>T	c.(562-564)ACG>ATG	p.T188M	uc001lpy.2_RNA|uc001lpz.2_5'Flank|RASSF7_uc001lqa.2_5'Flank	NM_173573	NP_775844	Q8IXW0	CK035_HUMAN	hypothetical protein LOC256329	188										pancreas(1)	1		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.18e-28)|Epithelial(43;6.93e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.97e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)														---	---	---	---
OR8J1	219477	broad.mit.edu	37	11	56128624	56128624	+	Missense_Mutation	SNP	C	A	A			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:56128624C>A	uc010rjh.1	+	1	902	c.902C>A	c.(901-903)GCT>GAT	p.A301D		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	301	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)																	---	---	---	---
TRPC6	7225	broad.mit.edu	37	11	101375501	101375501	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:101375501G>A	uc001pgk.3	-	2	624	c.199C>T	c.(199-201)CGG>TGG	p.R67W	TRPC6_uc009ywy.2_Missense_Mutation_p.R67W|TRPC6_uc009ywz.1_Missense_Mutation_p.R67W	NM_004621	NP_004612	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel,	67	Cytoplasmic (Potential).				axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)														---	---	---	---
MCAM	4162	broad.mit.edu	37	11	119182655	119182655	+	Missense_Mutation	SNP	C	A	A	rs1131437		TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:119182655C>A	uc001pwf.2	-	10	1177	c.1148G>T	c.(1147-1149)GGC>GTC	p.G383V	MCAM_uc001pwg.1_5'Flank	NM_006500	NP_006491	P43121	MUC18_HUMAN	melanoma cell adhesion molecule	383	Ig-like C2-type 2.|Extracellular (Potential).			G -> D (in Ref. 1, 2 and 3).	anatomical structure morphogenesis|cell adhesion	integral to membrane|plasma membrane				ovary(2)|breast(1)|central_nervous_system(1)	4		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.78e-05)														---	---	---	---
HEPACAM	220296	broad.mit.edu	37	11	124794667	124794667	+	Silent	SNP	G	A	A			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:124794667G>A	uc001qbk.2	-	2	790	c.384C>T	c.(382-384)GAC>GAT	p.D128D	HEPACAM_uc009zbj.2_5'Flank|HEPACAM_uc001qbl.1_Silent_p.D128D	NM_152722	NP_689935	Q14CZ8	HECAM_HUMAN	hepatocyte cell adhesion molecule precursor	128	Extracellular (Potential).|Ig-like V-type.				cell adhesion|cell cycle arrest|regulation of growth	cytoplasm|integral to membrane				pancreas(1)	1	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.54e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0308)														---	---	---	---
FGF6	2251	broad.mit.edu	37	12	4553300	4553300	+	Missense_Mutation	SNP	G	A	A	rs140216440		TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:4553300G>A	uc001qmr.1	-	2	493	c.449C>T	c.(448-450)ACG>ATG	p.T150M		NM_020996	NP_066276	P10767	FGF6_HUMAN	fibroblast growth factor 6 precursor	150					angiogenesis|cell proliferation|cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell division|positive regulation of cell proliferation	extracellular space	growth factor activity			lung(2)|ovary(1)	3			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)															---	---	---	---
A2M	2	broad.mit.edu	37	12	9229395	9229395	+	Missense_Mutation	SNP	C	A	A			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:9229395C>A	uc001qvk.1	-	28	3602	c.3489G>T	c.(3487-3489)AGG>AGT	p.R1163S	A2M_uc001qvj.1_Missense_Mutation_p.R205S|A2M_uc009zgk.1_Missense_Mutation_p.R1013S	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	1163					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)													---	---	---	---
IAPP	3375	broad.mit.edu	37	12	21531349	21531349	+	Missense_Mutation	SNP	T	A	A			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:21531349T>A	uc001rev.2	+	3	411	c.259T>A	c.(259-261)TTG>ATG	p.L87M	SLCO1A2_uc001res.2_Intron|SLCO1A2_uc010siq.1_Intron	NM_000415	NP_000406	P10997	IAPP_HUMAN	islet amyloid polypeptide precursor	87					apoptosis|cell-cell signaling|endocrine pancreas development|signal transduction	extracellular region|soluble fraction	hormone activity				0					Perindopril(DB00790)													---	---	---	---
PDZRN4	29951	broad.mit.edu	37	12	41946487	41946487	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:41946487A>C	uc010skn.1	+	6	704	c.636A>C	c.(634-636)CAA>CAC	p.Q212H	PDZRN4_uc001rmq.3_Missense_Mutation_p.Q153H|PDZRN4_uc009zjz.2_Missense_Mutation_p.Q151H|PDZRN4_uc001rmr.2_Missense_Mutation_p.Q38H	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	411	PDZ 2.						ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)																---	---	---	---
GPD1	2819	broad.mit.edu	37	12	50501593	50501593	+	Intron	SNP	G	A	A			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:50501593G>A	uc001rvz.2	+						GPD1_uc001rwa.2_Intron	NM_005276	NP_005267			glycerol-3-phosphate dehydrogenase 1 (soluble)						glycerol-3-phosphate catabolic process|triglyceride biosynthetic process	cytosol|glycerol-3-phosphate dehydrogenase complex	glycerol-3-phosphate dehydrogenase|protein homodimerization activity				0					NADH(DB00157)													---	---	---	---
E2F7	144455	broad.mit.edu	37	12	77417916	77417916	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:77417916G>A	uc001sym.3	-	13	2851	c.2615C>T	c.(2614-2616)ACG>ATG	p.T872M	E2F7_uc009zse.2_3'UTR	NM_203394	NP_976328	Q96AV8	E2F7_HUMAN	E2F transcription factor 7	872					cell cycle	transcription factor complex	DNA binding|identical protein binding			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3																		---	---	---	---
TCTN2	79867	broad.mit.edu	37	12	124171418	124171418	+	Silent	SNP	G	T	T			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:124171418G>T	uc001ufp.2	+	6	728	c.600G>T	c.(598-600)CGG>CGT	p.R200R	TCTN2_uc009zya.2_Silent_p.R199R	NM_024809	NP_079085	Q96GX1	TECT2_HUMAN	tectonic family member 2 isoform 1	200	Extracellular (Potential).				cilium assembly|smoothened signaling pathway	integral to membrane				ovary(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000163)|Epithelial(86;0.000502)|all cancers(50;0.00451)														---	---	---	---
FRY	10129	broad.mit.edu	37	13	32760399	32760399	+	Missense_Mutation	SNP	C	G	G			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:32760399C>G	uc001utx.2	+	27	3818	c.3322C>G	c.(3322-3324)CAC>GAC	p.H1108D	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	1108					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)														---	---	---	---
PRKCH	5583	broad.mit.edu	37	14	61917668	61917668	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:61917668C>T	uc001xfn.2	+	6	1116	c.811C>T	c.(811-813)CGA>TGA	p.R271*	PRKCH_uc010tsa.1_Nonsense_Mutation_p.R110*	NM_006255	NP_006246	P24723	KPCL_HUMAN	protein kinase C, eta	271	Phorbol-ester/DAG-type 2.				intracellular signal transduction|platelet activation	cytosol|plasma membrane	ATP binding|enzyme binding|metal ion binding|protein kinase C activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|large_intestine(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(108;0.045)|BRCA - Breast invasive adenocarcinoma(234;0.0906)|KIRC - Kidney renal clear cell carcinoma(182;0.182)														---	---	---	---
RGS6	9628	broad.mit.edu	37	14	72976881	72976881	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:72976881C>T	uc001xna.3	+	14	1508	c.985C>T	c.(985-987)CGA>TGA	p.R329*	RGS6_uc010ttn.1_Nonsense_Mutation_p.R329*|RGS6_uc001xmx.3_Nonsense_Mutation_p.R329*|RGS6_uc010tto.1_RNA|RGS6_uc001xmy.3_Nonsense_Mutation_p.R329*|RGS6_uc010ttp.1_Nonsense_Mutation_p.R260*|RGS6_uc001xmz.1_Nonsense_Mutation_p.R190*	NM_004296	NP_004287	P49758	RGS6_HUMAN	regulator of G-protein signalling 6	329	G protein gamma.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			upper_aerodigestive_tract(1)|lung(1)|skin(1)	3				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)														---	---	---	---
ACAN	176	broad.mit.edu	37	15	89382268	89382268	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:89382268G>A	uc010upo.1	+	3	819	c.445G>A	c.(445-447)GTG>ATG	p.V149M	ACAN_uc002bmx.2_Missense_Mutation_p.V149M|ACAN_uc010upp.1_Missense_Mutation_p.V149M|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	149					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)															---	---	---	---
GTF3C1	2975	broad.mit.edu	37	16	27472881	27472881	+	Silent	SNP	G	T	T			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:27472881G>T	uc002dov.1	-	37	6160	c.6120C>A	c.(6118-6120)GGC>GGA	p.G2040G	GTF3C1_uc002dou.2_Silent_p.G2015G	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	2040						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5																		---	---	---	---
N4BP1	9683	broad.mit.edu	37	16	48594664	48594664	+	Splice_Site	SNP	C	T	T			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:48594664C>T	uc002efp.2	-	2	2126	c.1889_splice	c.e2+1	p.T630_splice		NM_153029	NP_694574			Nedd4 binding protein 1						negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination	nucleolus|PML body					0		all_cancers(37;0.179)|all_lung(18;0.11)																---	---	---	---
CDH1	999	broad.mit.edu	37	16	68847399	68847399	+	Splice_Site	SNP	G	T	T			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:68847399G>T	uc002ewg.1	+	9	1444	c.1320_splice	c.e9+1	p.K440_splice	CDH1_uc010vlj.1_Splice_Site|CDH1_uc010cfg.1_Intron	NM_004360	NP_004351			cadherin 1, type 1 preproprotein						adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding	p.?(3)		breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)				Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer				---	---	---	---
P2RX1	5023	broad.mit.edu	37	17	3802234	3802234	+	Silent	SNP	G	A	A	rs139414872		TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:3802234G>A	uc002fww.2	-	9	1401	c.960C>T	c.(958-960)GAC>GAT	p.D320D		NM_002558	NP_002549	P51575	P2RX1_HUMAN	purinergic receptor P2X1	320	Extracellular (Potential).				platelet activation	integral to plasma membrane	calcium channel activity|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity			ovary(1)|skin(1)	2				LUAD - Lung adenocarcinoma(2;1.9e-05)|Lung(3;0.0173)														---	---	---	---
PLD2	5338	broad.mit.edu	37	17	4717978	4717978	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:4717978G>A	uc002fzc.2	+	12	1246	c.1145G>A	c.(1144-1146)AGA>AAA	p.R382K	PLD2_uc010vsj.1_Missense_Mutation_p.R239K|PLD2_uc002fzd.2_Missense_Mutation_p.R382K	NM_002663	NP_002654	O14939	PLD2_HUMAN	phospholipase D2	382					cell communication|cytoskeleton organization|small GTPase mediated signal transduction		NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	5					Choline(DB00122)													---	---	---	---
GFAP	2670	broad.mit.edu	37	17	42992568	42992568	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:42992568G>A	uc002ihq.2	-	1	347	c.287C>T	c.(286-288)GCG>GTG	p.A96V	GFAP_uc002ihr.2_Missense_Mutation_p.A96V|GFAP_uc010wjg.1_RNA	NM_002055	NP_002046	P14136	GFAP_HUMAN	glial fibrillary acidic protein isoform 1	96	Rod.|Coil 1A.					cytoplasm|intermediate filament	structural constituent of cytoskeleton			ovary(1)|pancreas(1)	2		Prostate(33;0.0959)																---	---	---	---
ITGB4	3691	broad.mit.edu	37	17	73723521	73723521	+	Silent	SNP	C	T	T			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73723521C>T	uc002jpg.2	+	4	386	c.199C>T	c.(199-201)CTG>TTG	p.L67L	ITGB4_uc002jph.2_Silent_p.L67L|ITGB4_uc010dgo.2_Silent_p.L67L|ITGB4_uc002jpi.3_Silent_p.L67L|ITGB4_uc010dgp.1_Silent_p.L67L|ITGB4_uc002jpj.2_Silent_p.L67L	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	67	PSI.|Extracellular (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)															---	---	---	---
DSC1	1823	broad.mit.edu	37	18	28710517	28710517	+	Missense_Mutation	SNP	G	T	T			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:28710517G>T	uc002kwn.2	-	16	2907	c.2645C>A	c.(2644-2646)CCC>CAC	p.P882H	DSC1_uc002kwm.2_3'UTR|uc002kwo.1_5'Flank	NM_024421	NP_077739	Q08554	DSC1_HUMAN	desmocollin 1 isoform Dsc1a preproprotein	882	Cytoplasmic (Potential).				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(10;0.00778)															---	---	---	---
KLHL14	57565	broad.mit.edu	37	18	30349740	30349740	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:30349740G>A	uc002kxm.1	-	2	1203	c.815C>T	c.(814-816)CCG>CTG	p.P272L		NM_020805	NP_065856	Q9P2G3	KLH14_HUMAN	kelch-like 14	272	BACK.					cytosol|endoplasmic reticulum membrane				ovary(1)	1																		---	---	---	---
EMR1	2015	broad.mit.edu	37	19	6904148	6904148	+	Missense_Mutation	SNP	C	A	A			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6904148C>A	uc002mfw.2	+	8	942	c.904C>A	c.(904-906)CCC>ACC	p.P302T	EMR1_uc010dvc.2_Missense_Mutation_p.P302T|EMR1_uc010dvb.2_Missense_Mutation_p.P250T|EMR1_uc010xji.1_Missense_Mutation_p.P161T|EMR1_uc010xjj.1_Intron	NM_001974	NP_001965	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone	302	Extracellular (Potential).|EGF-like 6; calcium-binding (Potential).				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	all_hematologic(4;0.166)																	---	---	---	---
NDUFA13	51079	broad.mit.edu	37	19	19646380	19646380	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19646380G>A	uc010xqy.1	+	7	1091	c.832G>A	c.(832-834)GTA>ATA	p.V278I	YJEFN3_uc002nmt.1_Missense_Mutation_p.V196I|YJEFN3_uc010ecf.1_Missense_Mutation_p.V146I|YJEFN3_uc002nmu.1_RNA|CILP2_uc002nmv.3_5'Flank|CILP2_uc002nmw.3_5'Flank	NM_015965	NP_057049	Q9P0J0	NDUAD_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	Error:Variant_position_missing_in_Q9P0J0_after_alignment					apoptotic nuclear change|induction of apoptosis by extracellular signals|negative regulation of cell growth|negative regulation of transcription, DNA-dependent|negative regulation of translation|protein import into nucleus|reactive oxygen species metabolic process|respiratory electron transport chain	integral to membrane|mitochondrial respiratory chain complex I|nucleoplasm	ATP binding|NADH dehydrogenase (ubiquinone) activity|protein binding				0					NADH(DB00157)													---	---	---	---
ZNF99	7652	broad.mit.edu	37	19	22939932	22939932	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:22939932T>G	uc010xrh.1	-	6	2399	c.2399A>C	c.(2398-2400)AAG>ACG	p.K800T		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)																---	---	---	---
ZSCAN1	284312	broad.mit.edu	37	19	58565264	58565264	+	Missense_Mutation	SNP	C	T	T	rs144536843	byFrequency	TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58565264C>T	uc002qrc.1	+	6	1319	c.1072C>T	c.(1072-1074)CGG>TGG	p.R358W		NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	358					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)														---	---	---	---
SFRS15	57466	broad.mit.edu	37	21	33068535	33068535	+	Splice_Site	SNP	C	T	T			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:33068535C>T	uc002ypd.2	-	9	1386	c.960_splice	c.e9-1	p.F320_splice	SFRS15_uc002ype.2_Splice_Site_p.F320_splice|SFRS15_uc010glu.2_Splice_Site_p.F305_splice|SFRS15_uc002ypf.1_Splice_Site	NM_020706	NP_065757			splicing factor, arginine/serine-rich 15 isoform							nucleus	nucleotide binding|RNA binding				0																		---	---	---	---
C21orf63	59271	broad.mit.edu	37	21	33825767	33825767	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:33825767C>T	uc002ypr.1	+	2	718	c.308C>T	c.(307-309)GCC>GTC	p.A103V	C21orf63_uc002ypq.1_Missense_Mutation_p.A103V|C21orf63_uc002yps.1_Intron|C21orf63_uc010glw.1_Missense_Mutation_p.A103V|C21orf63_uc002ypt.1_Intron|C21orf63_uc002ypu.1_Missense_Mutation_p.A8V	NM_058187	NP_478067	P58658	CU063_HUMAN	hypothetical protein LOC59271 precursor	103	SUEL-type lectin 1.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(2)|pancreas(1)	3																OREG0003572	type=REGULATORY REGION|Gene=C21orf63|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	---	---	---	---
P2RY8	286530	broad.mit.edu	37	X	1584583	1584583	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:1584583G>A	uc004cpz.2	-	2	1117	c.869C>T	c.(868-870)CCG>CTG	p.P290L		NM_178129	NP_835230	Q86VZ1	P2RY8_HUMAN	G-protein coupled purinergic receptor P2Y8	290	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(5)	5		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)						T	CRLF2	B-ALL|Downs associated ALL								---	---	---	---
MSL3	10943	broad.mit.edu	37	X	11793170	11793170	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:11793170G>A	uc004cuw.2	+	13	1643	c.1538G>A	c.(1537-1539)AGC>AAC	p.S513N	MSL3_uc004cux.2_Missense_Mutation_p.S454N|MSL3_uc011mig.1_Missense_Mutation_p.S364N|MSL3_uc011mih.1_Missense_Mutation_p.S501N|MSL3_uc004cuy.2_Missense_Mutation_p.S347N	NM_078629	NP_523353	Q8N5Y2	MS3L1_HUMAN	male-specific lethal 3-like 1 isoform a	513					histone H4-K16 acetylation|multicellular organismal development|transcription from RNA polymerase II promoter	MSL complex	DNA binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1																		---	---	---	---
KLHL34	257240	broad.mit.edu	37	X	21674200	21674200	+	Silent	SNP	G	A	A			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:21674200G>A	uc004czz.1	-	1	2249	c.1707C>T	c.(1705-1707)GTC>GTT	p.V569V		NM_153270	NP_695002	Q8N239	KLH34_HUMAN	kelch-like 34	569	Kelch 5.									ovary(1)	1																		---	---	---	---
MAGEB3	4114	broad.mit.edu	37	X	30254217	30254217	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:30254217G>A	uc004dca.1	+	5	913	c.176G>A	c.(175-177)CGT>CAT	p.R59H		NM_002365	NP_002356	O15480	MAGB3_HUMAN	melanoma antigen family B, 3	59											0																		---	---	---	---
FAM120C	54954	broad.mit.edu	37	X	54161998	54161998	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:54161998C>T	uc004dsz.3	-	6	1381	c.1298G>A	c.(1297-1299)CGA>CAA	p.R433Q	FAM120C_uc011moh.1_Missense_Mutation_p.R433Q	NM_017848	NP_060318	Q9NX05	F120C_HUMAN	hypothetical protein LOC54954	433										ovary(1)|central_nervous_system(1)	2																		---	---	---	---
MAGEE1	57692	broad.mit.edu	37	X	75650723	75650723	+	Silent	SNP	A	G	G			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:75650723A>G	uc004ecm.1	+	1	2607	c.2400A>G	c.(2398-2400)ACA>ACG	p.T800T		NM_020932	NP_065983	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	800	Interaction with DTNA (By similarity).|MAGE 2.					dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|ovary(1)|pancreas(1)|skin(1)	6																		---	---	---	---
ZCCHC5	203430	broad.mit.edu	37	X	77912593	77912593	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:77912593C>T	uc004edc.1	-	2	1621	c.1325G>A	c.(1324-1326)GGC>GAC	p.G442D		NM_152694	NP_689907	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	442							nucleic acid binding|zinc ion binding			ovary(1)	1																		---	---	---	---
COL4A6	1288	broad.mit.edu	37	X	107431078	107431078	+	Silent	SNP	C	T	T			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:107431078C>T	uc004enw.3	-	22	1873	c.1770G>A	c.(1768-1770)CCG>CCA	p.P590P	COL4A6_uc004env.3_Silent_p.P589P|COL4A6_uc011msn.1_Silent_p.P589P|COL4A6_uc010npk.2_Silent_p.P589P	NM_001847	NP_001838	Q14031	CO4A6_HUMAN	type IV alpha 6 collagen isoform A precursor	590	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(6)|urinary_tract(1)|large_intestine(1)	8														Alport_syndrome_with_Diffuse_Leiomyomatosis				---	---	---	---
IL13RA1	3597	broad.mit.edu	37	X	117895118	117895118	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:117895118C>T	uc004eqs.2	+	6	737	c.694C>T	c.(694-696)CAT>TAT	p.H232Y	IL13RA1_uc004eqr.1_Missense_Mutation_p.H232Y|IL13RA1_uc004eqt.1_Missense_Mutation_p.H232Y	NM_001560	NP_001551	P78552	I13R1_HUMAN	interleukin 13 receptor, alpha 1 precursor	232	Extracellular (Potential).					interleukin-13 receptor complex	cytokine receptor activity				0																		---	---	---	---
SAGE1	55511	broad.mit.edu	37	X	134989523	134989523	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:134989523C>T	uc004ezh.2	+	9	1096	c.929C>T	c.(928-930)CCG>CTG	p.P310L	SAGE1_uc010nry.1_Missense_Mutation_p.P279L|SAGE1_uc011mvv.1_Intron	NM_018666	NP_061136	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	310										ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
MAP7D3	79649	broad.mit.edu	37	X	135310825	135310825	+	Nonsense_Mutation	SNP	C	A	A			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:135310825C>A	uc004ezt.2	-	11	1934	c.1843G>T	c.(1843-1845)GAA>TAA	p.E615*	MAP7D3_uc004ezs.2_Nonsense_Mutation_p.E579*|MAP7D3_uc011mwc.1_Nonsense_Mutation_p.E597*|MAP7D3_uc010nsa.1_Nonsense_Mutation_p.E573*	NM_024597	NP_078873	Q8IWC1	MA7D3_HUMAN	MAP7 domain containing 3	615	Potential.					cytoplasm|spindle				ovary(2)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
MAGEC3	139081	broad.mit.edu	37	X	140983168	140983168	+	Silent	SNP	C	T	T			TCGA-D7-6522-01	TCGA-D7-6522-01									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:140983168C>T	uc011mwp.1	+	5	1023	c.1023C>T	c.(1021-1023)AGC>AGT	p.S341S	MAGEC3_uc004fbs.2_5'UTR|MAGEC3_uc010nsj.2_5'Flank	NM_138702	NP_619647	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3 isoform 1	341	MAGE 1.									skin(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
