Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_status	validation_method	validation_tumor_sample	validation_alt_allele
TNFRSF18	8784	broad.mit.edu	37	1	1139982	1139983	+	Intron	INS	-	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:1139982_1139983insC	uc001adc.2	-						TNFRSF18_uc001ada.2_Intron|TNFRSF18_uc001adb.2_Intron|TNFRSF18_uc001add.2_Intron	NM_004195	NP_004186			tumor necrosis factor receptor superfamily,						anti-apoptosis|apoptosis	extracellular region|integral to plasma membrane	tumor necrosis factor receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.73e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.01e-21)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)														---	---	---	---
VWA1	64856	broad.mit.edu	37	1	1372689	1372689	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:1372689delC	uc001afs.2	+	2	676	c.456delC	c.(454-456)GGCfs	p.G152fs	VWA1_uc001afr.2_Intron	NM_022834	NP_073745	Q6PCB0	VWA1_HUMAN	von Willebrand factor A domain containing 1	152	VWFA.					basement membrane					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)														---	---	---	---
NADK	65220	broad.mit.edu	37	1	1684156	1684156	+	3'UTR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:1684156delA	uc009vkw.2	-	12					NADK_uc001aic.2_3'UTR|NADK_uc001aid.3_3'UTR|NADK_uc001aie.2_3'UTR|NADK_uc010nyv.1_3'UTR	NM_023018	NP_075394			NAD kinase						ATP metabolic process|NAD metabolic process|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|NAD+ kinase activity|protein binding				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.61e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;8.75e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.33e-23)|GBM - Glioblastoma multiforme(42;1.35e-07)|Colorectal(212;0.000203)|COAD - Colon adenocarcinoma(227;0.000225)|Kidney(185;0.00265)|STAD - Stomach adenocarcinoma(132;0.00655)|BRCA - Breast invasive adenocarcinoma(365;0.00855)|KIRC - Kidney renal clear cell carcinoma(229;0.0382)|Lung(427;0.207)														---	---	---	---
KIAA1751	85452	broad.mit.edu	37	1	1890705	1890705	+	Intron	DEL	T	-	-	rs76796294		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:1890705delT	uc001aim.1	-						KIAA1751_uc009vkz.1_Intron	NM_001080484	NP_001073953			hypothetical protein LOC85452											pancreas(1)	1	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;8.79e-39)|OV - Ovarian serous cystadenocarcinoma(86;9.61e-25)|GBM - Glioblastoma multiforme(42;1.2e-07)|Colorectal(212;4.84e-05)|COAD - Colon adenocarcinoma(227;0.000214)|Kidney(185;0.00254)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)														---	---	---	---
PRKCZ	5590	broad.mit.edu	37	1	2106354	2106354	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:2106354delT	uc001aiq.2	+						PRKCZ_uc001air.2_Intron|PRKCZ_uc010nyw.1_Intron|PRKCZ_uc001ais.2_Intron|PRKCZ_uc009vla.2_Intron|PRKCZ_uc010nyx.1_Intron|PRKCZ_uc001ait.2_Intron	NM_002744	NP_002735			protein kinase C, zeta isoform 1						anti-apoptosis|intracellular signal transduction|negative regulation of insulin receptor signaling pathway|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein complex assembly|peptidyl-serine phosphorylation|platelet activation	endosome	ATP binding|protein kinase C activity|zinc ion binding			central_nervous_system(4)|large_intestine(2)	6	all_cancers(77;0.000177)|all_epithelial(69;6.41e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;1.14e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.96e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.3e-23)|GBM - Glioblastoma multiforme(42;2.85e-08)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00294)|BRCA - Breast invasive adenocarcinoma(365;0.00493)|STAD - Stomach adenocarcinoma(132;0.00669)|KIRC - Kidney renal clear cell carcinoma(229;0.0411)|Lung(427;0.213)												OREG0013007	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
C1orf86	199990	broad.mit.edu	37	1	2116337	2116337	+	3'UTR	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:2116337delC	uc001aix.1	-	8					PRKCZ_uc001aiq.2_Intron|PRKCZ_uc001air.2_Intron|PRKCZ_uc010nyw.1_Intron|PRKCZ_uc001ais.2_Intron|PRKCZ_uc009vla.2_Intron|PRKCZ_uc010nyx.1_Intron|PRKCZ_uc001ait.2_Intron|uc009vlc.1_5'Flank|C1orf86_uc001aiv.1_RNA|C1orf86_uc001aiw.1_RNA					SubName: Full=cDNA FLJ46112 fis, clone TESTI2035962;												0	all_cancers(77;0.000134)|all_epithelial(69;4.45e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;1.14e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.09e-37)|OV - Ovarian serous cystadenocarcinoma(86;1.5e-23)|GBM - Glioblastoma multiforme(42;1.61e-08)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00437)|STAD - Stomach adenocarcinoma(132;0.0134)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)														---	---	---	---
AJAP1	55966	broad.mit.edu	37	1	4832153	4832156	+	Intron	DEL	TTTA	-	-	rs74449743	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:4832153_4832156delTTTA	uc001alm.1	+						AJAP1_uc001aln.2_Intron	NM_001042478	NP_001035943			adherens junction associated protein 1						cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				lung(1)	1	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)														---	---	---	---
RPL22	6146	broad.mit.edu	37	1	6257785	6257785	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:6257785delT	uc001amd.2	-	2	90	c.44delA	c.(43-45)AAGfs	p.K15fs	RPL22_uc001ame.2_Frame_Shift_Del_p.K15fs	NM_000983	NP_000974	P35268	RL22_HUMAN	ribosomal protein L22 proprotein	15					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	heparin binding|RNA binding|structural constituent of ribosome				0	Ovarian(185;0.0634)	all_cancers(23;2.78e-38)|all_epithelial(116;8.88e-22)|all_lung(118;7.95e-08)|Lung NSC(185;1.6e-06)|all_neural(13;3.18e-06)|all_hematologic(16;8.99e-06)|Acute lymphoblastic leukemia(12;0.000365)|Breast(487;0.000496)|Renal(390;0.0007)|Colorectal(325;0.00104)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)|Medulloblastoma(700;0.211)		Epithelial(90;4.53e-38)|GBM - Glioblastoma multiforme(13;3.33e-32)|OV - Ovarian serous cystadenocarcinoma(86;2.8e-19)|Colorectal(212;6.8e-08)|COAD - Colon adenocarcinoma(227;8.04e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00311)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.182)				T	RUNX1	AML|CML								---	---	---	---
CAMTA1	23261	broad.mit.edu	37	1	7731110	7731110	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:7731110delC	uc001aoi.2	+						CAMTA1_uc010nzv.1_5'Flank	NM_015215	NP_056030			calmodulin-binding transcription activator 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)														---	---	---	---
RERE	473	broad.mit.edu	37	1	8420317	8420318	+	Frame_Shift_Ins	INS	-	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:8420317_8420318insC	uc001ape.2	-	19	4059_4060	c.3249_3250insG	c.(3247-3252)GGGTCGfs	p.G1083fs	RERE_uc001apf.2_Frame_Shift_Ins_p.G1083fs|RERE_uc010nzx.1_Frame_Shift_Ins_p.G815fs|RERE_uc001apd.2_Frame_Shift_Ins_p.G529fs	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	1083_1084	Pro-rich.				multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)														---	---	---	---
SLC25A33	84275	broad.mit.edu	37	1	9642611	9642611	+	3'UTR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:9642611delT	uc001apw.2	+	7					SLC25A33_uc001apx.2_3'UTR	NM_032315	NP_115691			mitochondrial carrier protein MGC4399						transport	integral to membrane|mitochondrial inner membrane					0	all_lung(157;0.246)	all_epithelial(116;1.16e-18)|all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Breast(348;0.00191)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.44e-05)|Kidney(185;0.000262)|KIRC - Kidney renal clear cell carcinoma(229;0.000957)|BRCA - Breast invasive adenocarcinoma(304;0.0019)|STAD - Stomach adenocarcinoma(132;0.00355)|READ - Rectum adenocarcinoma(331;0.0419)														---	---	---	---
KIF1B	23095	broad.mit.edu	37	1	10292359	10292360	+	5'UTR	INS	-	AT	AT	rs139352306	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:10292359_10292360insAT	uc001aqx.3	+	2					KIF1B_uc001aqv.3_5'UTR|KIF1B_uc001aqw.3_5'UTR|KIF1B_uc001aqy.2_5'UTR|KIF1B_uc001aqz.2_5'UTR|KIF1B_uc001ara.2_5'UTR|KIF1B_uc001arb.2_5'UTR|KIF1B_uc009vmt.2_RNA	NM_015074	NP_055889			kinesin family member 1B isoform b						anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)														---	---	---	---
KIF1B	23095	broad.mit.edu	37	1	10412667	10412667	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:10412667delT	uc001aqx.3	+						KIF1B_uc001aqw.3_Intron|KIF1B_uc001aqy.2_Intron|KIF1B_uc001aqz.2_Intron|KIF1B_uc001ara.2_Intron|KIF1B_uc001arb.2_Intron	NM_015074	NP_055889			kinesin family member 1B isoform b						anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)														---	---	---	---
Unknown	0	broad.mit.edu	37	1	11370587	11370588	+	IGR	INS	-	CCCTTCCCACCTCCCTGC	CCCTTCCCACCTCCCTGC	rs141920128	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:11370587_11370588insCCCTTCCCACCTCCCTGC								UBIAD1 (22097 upstream) : PTCHD2 (168707 downstream)																																			---	---	---	---
SPEN	23013	broad.mit.edu	37	1	16245741	16245741	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:16245741delT	uc001axk.1	+						SPEN_uc010obp.1_Intron	NM_015001	NP_055816			spen homolog, transcriptional regulator						interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)														---	---	---	---
C1orf144	26099	broad.mit.edu	37	1	16695981	16695982	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:16695981_16695982insT	uc001aym.3	+						C1orf144_uc010ocb.1_Intron|C1orf144_uc001ayi.3_Intron|C1orf144_uc001ayk.3_Intron	NM_001114600	NP_001108072			putative MAPK activating protein PM20,PM21												0		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00475)|all_lung(284;0.00671)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|COAD - Colon adenocarcinoma(227;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;4.12e-05)|Kidney(64;0.00018)|KIRC - Kidney renal clear cell carcinoma(64;0.00267)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
UBR4	23352	broad.mit.edu	37	1	19467923	19467923	+	Frame_Shift_Del	DEL	G	-	-	rs145307465		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:19467923delG	uc001bbi.2	-	57	8410	c.8406delC	c.(8404-8406)CCCfs	p.P2802fs	UBR4_uc001bbk.1_Frame_Shift_Del_p.P484fs	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	2802					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)														---	---	---	---
KIAA0090	23065	broad.mit.edu	37	1	19545599	19545600	+	3'UTR	DEL	TC	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:19545599_19545600delTC	uc001bbo.2	-	23					KIAA0090_uc001bbn.2_RNA|KIAA0090_uc001bbp.2_3'UTR|KIAA0090_uc001bbq.2_3'UTR|KIAA0090_uc001bbr.2_3'UTR	NM_015047	NP_055862			hypothetical protein LOC23065 precursor							integral to membrane	protein binding			ovary(1)	1		Colorectal(325;0.000147)|Renal(390;0.000469)|Breast(348;0.00366)|all_lung(284;0.00519)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00492)|BRCA - Breast invasive adenocarcinoma(304;3.84e-05)|Kidney(64;0.000191)|KIRC - Kidney renal clear cell carcinoma(64;0.00274)|GBM - Glioblastoma multiforme(114;0.005)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0656)														---	---	---	---
MUL1	79594	broad.mit.edu	37	1	20829871	20829871	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:20829871delA	uc001bdi.3	-							NM_024544	NP_078820			mitochondrial ubiquitin ligase activator of NFKB						activation of caspase activity|activation of JUN kinase activity|induction of apoptosis|mitochondrial fission|mitochondrion localization|negative regulation of cell growth|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to mitochondrial outer membrane|nucleus|peroxisome	identical protein binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding				0		Colorectal(325;0.000147)|Renal(390;0.000469)|Lung NSC(340;0.00412)|all_lung(284;0.00419)|Breast(348;0.00748)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000137)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.00124)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)														---	---	---	---
EIF4G3	8672	broad.mit.edu	37	1	21175886	21175886	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:21175886delT	uc001bec.2	-						EIF4G3_uc010odi.1_Intron|EIF4G3_uc010odj.1_Intron|EIF4G3_uc009vpz.2_Intron|EIF4G3_uc001bed.2_Intron|EIF4G3_uc001bef.2_Intron|EIF4G3_uc001bee.2_Intron	NM_003760	NP_003751			eukaryotic translation initiation factor 4						interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)														---	---	---	---
KDM1A	23028	broad.mit.edu	37	1	23385431	23385431	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:23385431delT	uc001bgi.2	+						KDM1A_uc001bgj.2_Intron	NM_015013	NP_055828			lysine-specific histone demethylase 1 isoform b						blood coagulation|muscle cell development|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of protein binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin	androgen receptor binding|chromatin binding|enzyme binding|flavin adenine dinucleotide binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-K9 specific)|ligand-dependent nuclear receptor transcription coactivator activity|MyoD binding|oxidoreductase activity|p53 binding|transcription regulatory region DNA binding			ovary(1)|lung(1)	2																		---	---	---	---
ASAP3	55616	broad.mit.edu	37	1	23762668	23762668	+	Intron	DEL	T	-	-	rs77206819		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:23762668delT	uc001bha.2	-						ASAP3_uc001bgy.1_Intron|ASAP3_uc001bgz.1_Intron|ASAP3_uc010odz.1_Intron|ASAP3_uc010oea.1_Intron|ASAP3_uc001bhb.2_Intron	NM_017707	NP_060177			ArfGAP with SH3 domain, ankyrin repeat and PH						regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3																		---	---	---	---
ASAP3	55616	broad.mit.edu	37	1	23768963	23768963	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:23768963delC	uc001bha.2	-						ASAP3_uc010odz.1_Intron|ASAP3_uc010oea.1_Intron	NM_017707	NP_060177			ArfGAP with SH3 domain, ankyrin repeat and PH						regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3																		---	---	---	---
NIPAL3	57185	broad.mit.edu	37	1	24768495	24768495	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:24768495delT	uc001bjh.2	+						NIPAL3_uc010oek.1_Intron|NIPAL3_uc001bjg.2_Intron|NIPAL3_uc009vrc.2_Intron	NM_020448	NP_065181			NIPA-like domain containing 3							integral to membrane					0																		---	---	---	---
SRRM1	10250	broad.mit.edu	37	1	24993264	24993264	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:24993264delA	uc001bjm.2	+						SRRM1_uc010oel.1_Intron|SRRM1_uc009vrh.1_Intron|SRRM1_uc009vri.1_Intron|SRRM1_uc010oem.1_Intron	NM_005839	NP_005830			serine/arginine repetitive matrix 1						mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nuclear matrix|nuclear speck	DNA binding|protein binding|RNA binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00125)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0422)|OV - Ovarian serous cystadenocarcinoma(117;1.01e-24)|Colorectal(126;5.95e-08)|COAD - Colon adenocarcinoma(152;3.24e-06)|GBM - Glioblastoma multiforme(114;0.000148)|BRCA - Breast invasive adenocarcinoma(304;0.00177)|KIRC - Kidney renal clear cell carcinoma(1967;0.00348)|STAD - Stomach adenocarcinoma(196;0.00483)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.138)														---	---	---	---
SYF2	25949	broad.mit.edu	37	1	25554441	25554441	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:25554441delT	uc001bjt.1	-						SYF2_uc001bju.1_Intron|SYF2_uc010oeo.1_Intron	NM_015484	NP_056299			SYF2 homolog, RNA splicing factor isoform 1							catalytic step 2 spliceosome					0		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.5e-26)|Colorectal(126;2.54e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000455)|STAD - Stomach adenocarcinoma(196;0.000766)|KIRC - Kidney renal clear cell carcinoma(1967;0.00145)|GBM - Glioblastoma multiforme(114;0.00443)|READ - Rectum adenocarcinoma(331;0.0936)|Lung(427;0.201)														---	---	---	---
C1orf135	79000	broad.mit.edu	37	1	26186960	26186962	+	5'Flank	DEL	TTT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:26186960_26186962delTTT	uc001bkw.1	-							NM_024037	NP_076942			aurora A-binding protein												0		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00521)|all_lung(284;0.00764)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0675)|all_neural(195;0.117)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0429)|OV - Ovarian serous cystadenocarcinoma(117;3.28e-25)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;1.75e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000787)|BRCA - Breast invasive adenocarcinoma(304;0.00102)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.015)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
CNKSR1	10256	broad.mit.edu	37	1	26504171	26504171	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:26504171delA	uc001bln.3	+						CNKSR1_uc010oex.1_Intron|CNKSR1_uc001blm.3_Intron|CNKSR1_uc009vsd.2_Intron|CNKSR1_uc009vse.2_Intron|CNKSR1_uc001blo.2_5'Flank	NM_006314	NP_006305			connector enhancer of kinase suppressor of Ras						Rho protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cell cortex|cell-cell junction	protein binding, bridging			lung(1)|kidney(1)	2		Colorectal(325;3.46e-05)|all_lung(284;0.000116)|Lung NSC(340;0.000154)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.72e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|BRCA - Breast invasive adenocarcinoma(304;0.000959)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00823)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
CATSPER4	378807	broad.mit.edu	37	1	26528147	26528147	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:26528147delT	uc010oez.1	+						CATSPER4_uc009vsf.2_Intron	NM_198137	NP_937770			cation channel, sperm associated 4						cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			ovary(1)	1		all_cancers(24;2.05e-18)|Colorectal(325;0.000147)|Renal(390;0.00211)|all_lung(284;0.00218)|Lung NSC(340;0.00239)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;3.52e-26)|Colorectal(126;1.34e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000755)|BRCA - Breast invasive adenocarcinoma(304;0.000995)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00878)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
ARID1A	8289	broad.mit.edu	37	1	27023769	27023769	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:27023769delC	uc001bmv.1	+	1	1248	c.875delC	c.(874-876)ACCfs	p.T292fs	ARID1A_uc001bmt.1_Frame_Shift_Del_p.T292fs|ARID1A_uc001bmu.1_Frame_Shift_Del_p.T292fs	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	292					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)				Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								---	---	---	---
ARID1A	8289	broad.mit.edu	37	1	27087189	27087189	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:27087189delT	uc001bmv.1	+						ARID1A_uc001bmt.1_Intron|ARID1A_uc001bmu.1_Intron|ARID1A_uc001bmw.1_Intron	NM_006015	NP_006006			AT rich interactive domain 1A isoform a						androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)				Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								---	---	---	---
Unknown	0	broad.mit.edu	37	1	27638137	27638137	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:27638137delA								WDTC1 (3029 upstream) : TMEM222 (10499 downstream)																																			---	---	---	---
C1orf38	9473	broad.mit.edu	37	1	28208354	28208354	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:28208354delA	uc001bpc.3	+						C1orf38_uc001boz.2_Intron|C1orf38_uc001bpa.2_Intron|C1orf38_uc010ofn.1_Intron|C1orf38_uc010ofo.1_Intron	NM_001105556	NP_001099026			basement membrane-induced gene isoform 3						cell adhesion|inflammatory response					ovary(1)	1		Colorectal(325;3.46e-05)|all_lung(284;0.000129)|Lung NSC(340;0.000259)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;2.52e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
EYA3	2140	broad.mit.edu	37	1	28300853	28300854	+	3'UTR	DEL	AG	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:28300853_28300854delAG	uc001bpi.1	-	18					EYA3_uc010ofs.1_3'UTR|EYA3_uc010oft.1_3'UTR	NM_001990	NP_001981			eyes absent 3						anatomical structure morphogenesis|double-strand break repair|histone dephosphorylation|multicellular organismal development|positive regulation of DNA repair|regulation of transcription, DNA-dependent|response to ionizing radiation|transcription, DNA-dependent|visual perception	cytoplasm	metal ion binding|protein binding|protein tyrosine phosphatase activity			ovary(2)|skin(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000414)|Lung NSC(340;0.000432)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0484)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;2.8e-06)|STAD - Stomach adenocarcinoma(196;0.00364)|KIRC - Kidney renal clear cell carcinoma(1967;0.00378)|BRCA - Breast invasive adenocarcinoma(304;0.00718)|READ - Rectum adenocarcinoma(331;0.0642)														---	---	---	---
PHACTR4	65979	broad.mit.edu	37	1	28780574	28780574	+	Intron	DEL	T	-	-	rs74354637	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:28780574delT	uc001bpw.2	+						PHACTR4_uc001bpu.2_Intron|PHACTR4_uc001bpv.1_Intron|PHACTR4_uc001bpx.2_Intron|PHACTR4_uc001bpy.2_Intron	NM_001048183	NP_001041648			phosphatase and actin regulator 4 isoform 1								actin binding|protein phosphatase inhibitor activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;7.01e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;1.35e-21)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0144)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
PHACTR4	65979	broad.mit.edu	37	1	28815614	28815614	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:28815614delA	uc001bpw.2	+						PHACTR4_uc001bpv.1_Intron|PHACTR4_uc001bpx.2_Intron|PHACTR4_uc001bpy.2_Intron|PHACTR4_uc001bpz.2_5'Flank	NM_001048183	NP_001041648			phosphatase and actin regulator 4 isoform 1								actin binding|protein phosphatase inhibitor activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;7.01e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;1.35e-21)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0144)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
SNHG3-RCC1	751867	broad.mit.edu	37	1	28833749	28833749	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:28833749delT	uc001bqa.1	+						SNHG3-RCC1_uc001bqb.1_Intron|SNHG3-RCC1_uc001bqc.1_Intron	NM_001048197	NP_001041662			regulator of chromosome condensation 1												0		Colorectal(325;3.46e-05)|Lung NSC(340;0.000318)|all_lung(284;0.000434)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.00989)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
Unknown	0	broad.mit.edu	37	1	29460062	29460062	+	IGR	DEL	A	-	-	rs12034124		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:29460062delA								TMEM200B (9655 upstream) : SFRS4 (14189 downstream)																																			---	---	---	---
MECR	51102	broad.mit.edu	37	1	29542401	29542401	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:29542401delA	uc001brq.1	-						MECR_uc001brp.1_Intron|MECR_uc001brr.1_Intron|MECR_uc001brs.1_Intron|MECR_uc001brt.1_Intron|MECR_uc010ofz.1_Intron	NM_016011	NP_057095			trans-2-enoyl-CoA reductase, mitochondrial						fatty acid biosynthetic process	mitochondrion	trans-2-enoyl-CoA reductase (NADPH) activity|zinc ion binding			ovary(1)	1		Colorectal(325;0.000389)|Breast(348;0.00765)|Lung NSC(340;0.0081)|all_lung(284;0.00914)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;3.39e-07)|COAD - Colon adenocarcinoma(152;2.04e-05)|STAD - Stomach adenocarcinoma(196;0.0195)|BRCA - Breast invasive adenocarcinoma(304;0.053)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.137)														---	---	---	---
BSDC1	55108	broad.mit.edu	37	1	32834302	32834302	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:32834302delT	uc001bvh.3	-						BSDC1_uc010ohg.1_Intron|BSDC1_uc010ohh.1_Intron|BSDC1_uc010ohi.1_Intron|BSDC1_uc001bvg.3_Intron|BSDC1_uc001bvj.2_Intron|BSDC1_uc001bvi.2_Intron	NM_018045	NP_060515			BSD domain containing 1 isoform b								protein binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)																---	---	---	---
Unknown	0	broad.mit.edu	37	1	32888257	32888259	+	IGR	DEL	AAA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:32888257_32888259delAAA								BSDC1 (28195 upstream) : ZBTB8A (42399 downstream)																																			---	---	---	---
TRIM62	55223	broad.mit.edu	37	1	33647071	33647071	+	5'UTR	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:33647071delG	uc001bxb.2	-	1						NM_018207	NP_060677			tripartite motif-containing 62							intracellular	zinc ion binding				0		Myeloproliferative disorder(586;0.0393)																---	---	---	---
CLSPN	63967	broad.mit.edu	37	1	36203713	36203722	+	Intron	DEL	AAATATATAT	-	-	rs59268543	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:36203713_36203722delAAATATATAT	uc001bzi.2	-						CLSPN_uc009vux.2_Intron	NM_022111	NP_071394			claspin						activation of protein kinase activity|cell cycle|cellular component disassembly involved in apoptosis|DNA repair|DNA replication|G2/M transition DNA damage checkpoint|mitotic cell cycle DNA replication checkpoint|peptidyl-serine phosphorylation	nucleoplasm	anaphase-promoting complex binding|DNA binding			breast(2)|ovary(2)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)	8		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)																---	---	---	---
CLSPN	63967	broad.mit.edu	37	1	36219611	36219611	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:36219611delT	uc001bzi.2	-						CLSPN_uc009vux.2_Intron	NM_022111	NP_071394			claspin						activation of protein kinase activity|cell cycle|cellular component disassembly involved in apoptosis|DNA repair|DNA replication|G2/M transition DNA damage checkpoint|mitotic cell cycle DNA replication checkpoint|peptidyl-serine phosphorylation	nucleoplasm	anaphase-promoting complex binding|DNA binding			breast(2)|ovary(2)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)	8		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)																---	---	---	---
EIF2C3	192669	broad.mit.edu	37	1	36396956	36396956	+	5'UTR	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:36396956delC	uc001bzp.2	+	1					EIF2C3_uc001bzn.1_5'UTR|EIF2C3_uc001bzo.2_RNA|EIF2C3_uc001bzq.2_5'UTR	NM_024852	NP_079128			eukaryotic translation initiation factor 2C, 3						mRNA catabolic process|negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)																---	---	---	---
ADPRHL2	54936	broad.mit.edu	37	1	36556793	36556793	+	Intron	DEL	A	-	-	rs75314505		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:36556793delA	uc001bzt.2	+						ADPRHL2_uc001bzu.2_Intron	NM_017825	NP_060295			ADP-ribosylhydrolase like 2							cytoplasm|nucleus	metal ion binding|poly(ADP-ribose) glycohydrolase activity			pancreas(1)	1		Myeloproliferative disorder(586;0.0393)																---	---	---	---
MEAF6	64769	broad.mit.edu	37	1	37962171	37962171	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:37962171delA	uc001cbg.1	-						MEAF6_uc001cbd.1_Intron|MEAF6_uc001cbe.1_Intron|MEAF6_uc009vvd.1_Intron|MEAF6_uc001cbf.1_RNA|MEAF6_uc001cbh.1_3'UTR	NM_022756	NP_073593			MYST/Esa1-associated factor 6						histone H2A acetylation|histone H3-K14 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|NuA4 histone acetyltransferase complex|nucleolus	protein binding				0																		---	---	---	---
C1orf109	54955	broad.mit.edu	37	1	38155688	38155688	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:38155688delT	uc001cbp.2	-						C1orf109_uc010oig.1_Intron|C1orf109_uc001cbo.2_Intron|C1orf109_uc001cbq.1_Intron|CDCA8_uc001cbr.2_5'Flank|CDCA8_uc001cbs.2_5'Flank|CDCA8_uc010oih.1_5'Flank	NM_017850	NP_060320			hypothetical protein LOC54955												0		Myeloproliferative disorder(586;0.0393)																---	---	---	---
SF3A3	10946	broad.mit.edu	37	1	38446098	38446099	+	Intron	DEL	AA	-	-	rs113844754		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:38446098_38446099delAA	uc001cci.2	-						SF3A3_uc010oik.1_Intron	NM_006802	NP_006793			splicing factor 3a, subunit 3						nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nuclear speck	nucleic acid binding|protein binding|zinc ion binding				0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)																---	---	---	---
RHBDL2	54933	broad.mit.edu	37	1	39361598	39361599	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:39361598_39361599insT	uc001ccu.1	-						RHBDL2_uc010oin.1_Intron|RHBDL2_uc010oio.1_Intron	NM_017821	NP_060291			rhomboid protease 2						proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity				0	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;8.23e-17)															---	---	---	---
MACF1	23499	broad.mit.edu	37	1	39770238	39770239	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:39770238_39770239delTT	uc010ois.1	+						MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc009vvq.1_Intron|MACF1_uc001cdb.1_Intron	NM_012090	NP_036222			microfilament and actin filament cross-linker						cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)															---	---	---	---
TRIT1	54802	broad.mit.edu	37	1	40312897	40312897	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:40312897delA	uc010oiz.1	-	8	1015	c.1001delT	c.(1000-1002)TTGfs	p.L334fs	TRIT1_uc001cec.3_RNA|TRIT1_uc001ced.3_Frame_Shift_Del_p.L30fs|TRIT1_uc001cee.3_RNA|TRIT1_uc001cef.3_RNA|TRIT1_uc001ceg.3_Frame_Shift_Del_p.L88fs|TRIT1_uc001ceh.3_Frame_Shift_Del_p.L88fs|TRIT1_uc009vvv.2_Intron|TRIT1_uc001cei.3_Frame_Shift_Del_p.L88fs|TRIT1_uc001ceq.2_Frame_Shift_Del_p.L30fs|TRIT1_uc001cek.2_Frame_Shift_Del_p.L30fs|TRIT1_uc009vvx.2_Intron|TRIT1_uc001cel.2_Intron|TRIT1_uc001cem.2_Frame_Shift_Del_p.L252fs|TRIT1_uc001cen.2_Frame_Shift_Del_p.L88fs|TRIT1_uc001ceo.2_Frame_Shift_Del_p.L88fs|TRIT1_uc001cep.2_Frame_Shift_Del_p.L88fs	NM_017646	NP_060116	Q9H3H1	MOD5_HUMAN	tRNA isopentenyltransferase 1 precursor	334					tRNA processing	mitochondrion	ATP binding|metal ion binding|tRNA dimethylallyltransferase activity			ovary(1)	1	all_cancers(7;4.55e-14)|all_lung(5;1.23e-16)|all_epithelial(6;2.17e-16)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;3.29e-18)|Epithelial(16;3.07e-17)|all cancers(16;6.21e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)															---	---	---	---
SCMH1	22955	broad.mit.edu	37	1	41617397	41617397	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:41617397delA	uc001cgo.2	-						SCMH1_uc010ojr.1_Intron|SCMH1_uc001cgp.2_Intron|SCMH1_uc001cgr.2_Intron|SCMH1_uc001cgs.2_Intron|SCMH1_uc001cgt.2_Intron|SCMH1_uc001cgq.2_Intron|SCMH1_uc010ojs.1_Intron	NM_001031694	NP_001026864			sex comb on midleg 1 isoform 1						anatomical structure morphogenesis|gene silencing|multicellular organismal development|negative regulation of transcription, DNA-dependent		DNA binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)|Breast(333;0.162)	Myeloproliferative disorder(586;0.0393)																---	---	---	---
Unknown	0	broad.mit.edu	37	1	42607152	42607153	+	IGR	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:42607152_42607153delTT								HIVEP3 (105556 upstream) : GUCA2B (11939 downstream)																																			---	---	---	---
MED8	112950	broad.mit.edu	37	1	43853128	43853128	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:43853128delA	uc001cjg.3	-						MED8_uc001cje.1_Intron|MED8_uc001cjf.3_Intron|C1orf84_uc001cjh.2_5'Flank|C1orf84_uc001cji.1_5'Flank|KIAA0467_uc009vws.1_5'Flank	NM_201542	NP_963836			mediator complex subunit 8 isoform 1						regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)																---	---	---	---
IPO13	9670	broad.mit.edu	37	1	44426721	44426721	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:44426721delG	uc001ckx.2	+							NM_014652	NP_055467			importin 13						protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)																---	---	---	---
TOE1	114034	broad.mit.edu	37	1	45807064	45807064	+	Intron	DEL	G	-	-	rs3811432	byFrequency	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:45807064delG	uc009vxq.2	+						MUTYH_uc001cnf.2_5'Flank|MUTYH_uc009vxo.2_5'Flank|MUTYH_uc001cng.2_5'Flank|MUTYH_uc001cnj.2_5'Flank|MUTYH_uc001cni.2_5'Flank|MUTYH_uc001cnh.2_5'Flank|MUTYH_uc001cno.2_5'Flank|MUTYH_uc001cnk.2_5'Flank|MUTYH_uc010oll.1_5'Flank|MUTYH_uc001cnm.2_5'Flank|MUTYH_uc001cnl.2_5'Flank|MUTYH_uc009vxp.2_5'Flank|MUTYH_uc001cnn.2_5'Flank|TOE1_uc001cnq.3_Intron|TOE1_uc010olm.1_Intron|TOE1_uc010oln.1_Intron|TOE1_uc001cnr.3_Intron	NM_025077	NP_079353			target of EGR1, member 1 (nuclear)							nuclear speck|nucleolus	nucleic acid binding|zinc ion binding			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)																	---	---	---	---
TESK2	10420	broad.mit.edu	37	1	45821220	45821220	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:45821220delT	uc001cns.1	-						TESK2_uc009vxr.1_Intron|TESK2_uc010olo.1_Intron|TESK2_uc009vxs.1_Intron	NM_007170	NP_009101			testis-specific protein kinase 2						actin cytoskeleton organization|focal adhesion assembly|spermatogenesis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(2)|breast(2)|pancreas(1)	5	Acute lymphoblastic leukemia(166;0.155)																	---	---	---	---
GPBP1L1	60313	broad.mit.edu	37	1	46095127	46095129	+	Intron	DEL	CCC	-	-	rs74074404		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:46095127_46095129delCCC	uc001coq.2	-						GPBP1L1_uc001coo.2_Intron	NM_021639	NP_067652			GC-rich promoter binding protein 1-like 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)																	---	---	---	---
IPP	3652	broad.mit.edu	37	1	46179806	46179806	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:46179806delA	uc001cou.2	-						IPP_uc001cos.3_Intron	NM_005897	NP_005888			intracisternal A particle-promoted polypeptide							actin cytoskeleton|cytoplasm	actin binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)																	---	---	---	---
MAST2	23139	broad.mit.edu	37	1	46472273	46472273	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:46472273delA	uc001cov.2	+						MAST2_uc001cow.2_Intron|MAST2_uc001coy.1_Intron|MAST2_uc001coz.1_Intron|MAST2_uc009vya.2_Intron|MAST2_uc001cpa.2_Intron	NM_015112	NP_055927			microtubule associated serine/threonine kinase						regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			ovary(5)|lung(3)|stomach(2)|breast(1)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)																	---	---	---	---
MKNK1	8569	broad.mit.edu	37	1	47037895	47037895	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:47037895delT	uc001cqb.2	-						MKNK1_uc010omd.1_Intron|MKNK1_uc001cqc.2_Intron|MKNK1_uc009vyi.2_Intron|MKNK1_uc010ome.1_Intron|MKNK1_uc009vyj.2_Intron|MKNK1_uc001cqd.2_Intron	NM_003684	NP_003675			MAP kinase-interacting serine/threonine kinase 1						intracellular protein kinase cascade|peptidyl-serine phosphorylation|regulation of translation	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)	2	Acute lymphoblastic leukemia(166;0.155)																	---	---	---	---
CYP4Z2P	163720	broad.mit.edu	37	1	47365870	47365870	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:47365870delT	uc001cqo.1	-						CYP4Z2P_uc009vyn.1_Intron	NR_002788				Homo sapiens cDNA FLJ40054 fis, clone TBAES2000315, weakly similar to CYTOCHROME P450 4A1 (EC 1.14.15.3).												0																		---	---	---	---
CMPK1	51727	broad.mit.edu	37	1	47840989	47840989	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:47840989delA	uc001cri.2	+						CMPK1_uc010omp.1_Intron|CMPK1_uc010omq.1_Intron	NM_016308	NP_057392			UMP-CMP kinase 1 isoform a						nucleobase, nucleoside and nucleotide interconversion	cytosol|nucleus	ATP binding|cytidylate kinase activity|nucleoside phosphate kinase activity|uridine kinase activity			ovary(1)	1					Gemcitabine(DB00441)													---	---	---	---
ELAVL4	1996	broad.mit.edu	37	1	50572178	50572178	+	5'Flank	DEL	A	-	-	rs79810783		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:50572178delA	uc001csb.2	+						ELAVL4_uc001cry.3_Intron|ELAVL4_uc001crz.3_Intron|ELAVL4_uc001csa.3_Intron|ELAVL4_uc001csc.3_5'Flank	NM_021952	NP_068771			ELAV-like 4 isoform 1						mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			ovary(1)|pancreas(1)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	1	50865017	50865017	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:50865017delT								ELAVL4 (197477 upstream) : DMRTA2 (18212 downstream)																																			---	---	---	---
NRD1	4898	broad.mit.edu	37	1	52301764	52301764	+	Intron	DEL	A	-	-	rs115629064	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:52301764delA	uc001ctc.3	-						NRD1_uc009vzb.2_Intron|NRD1_uc001ctd.3_Intron|NRD1_uc001cte.2_Intron|NRD1_uc001ctf.2_Intron|NRD1_uc010ong.1_Intron|NRD1_uc009vzc.1_Intron	NM_002525	NP_002516			nardilysin isoform a						cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding				0																		---	---	---	---
TXNDC12	51060	broad.mit.edu	37	1	52520880	52520880	+	5'UTR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:52520880delT	uc001cti.2	-	1					BTF3L4_uc001ctk.2_5'Flank|BTF3L4_uc001ctl.2_5'Flank|BTF3L4_uc010onh.1_5'Flank	NM_015913	NP_056997			thioredoxin domain containing 12 precursor						activation of caspase activity|apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytosol|mitochondrial inner membrane|mitochondrial intermembrane space|nucleus|perinuclear region of cytoplasm	DNA binding|electron carrier activity|flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			ovary(1)	1																		---	---	---	---
ZFYVE9	9372	broad.mit.edu	37	1	52627783	52627783	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:52627783delA	uc001cto.2	+						ZFYVE9_uc001ctn.2_Intron|ZFYVE9_uc001ctp.2_Intron	NM_004799	NP_004790			zinc finger, FYVE domain containing 9 isoform 3						endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			ovary(2)|lung(2)|central_nervous_system(2)|skin(2)	8																		---	---	---	---
ZCCHC11	23318	broad.mit.edu	37	1	52923972	52923972	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:52923972delA	uc001ctx.2	-						ZCCHC11_uc001cty.2_Intron|ZCCHC11_uc001ctz.2_Intron|ZCCHC11_uc009vze.1_Intron|ZCCHC11_uc009vzf.1_Intron|ZCCHC11_uc001cua.1_Intron	NM_015269	NP_056084			zinc finger, CCHC domain containing 11 isoform						miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)|skin(1)	3																		---	---	---	---
ZYG11B	79699	broad.mit.edu	37	1	53287007	53287007	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:53287007delA	uc001cuj.2	+						ZYG11B_uc010onj.1_Intron|ZYG11B_uc009vzh.2_Intron	NM_024646	NP_078922			zyg-11 homolog B								protein binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4																		---	---	---	---
TMEM59	9528	broad.mit.edu	37	1	54502396	54502396	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:54502396delA	uc001cwp.2	-						TMEM59_uc001cwn.2_Intron|TMEM59_uc001cwo.2_Intron|TMEM59_uc001cwq.2_Intron|TMEM59_uc001cwr.2_Intron|TMEM59_uc001cws.1_Intron	NM_004872	NP_004863			thymic dendritic cell-derived factor 1							Golgi membrane|integral to membrane					0																		---	---	---	---
SSBP3	23648	broad.mit.edu	37	1	54870482	54870484	+	Intron	DEL	GGG	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:54870482_54870484delGGG	uc001cxe.2	-						SSBP3_uc001cxf.2_Intron|SSBP3_uc001cxg.2_Intron	NM_145716	NP_663768			single stranded DNA binding protein 3 isoform a						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	single-stranded DNA binding				0																		---	---	---	---
PRKAA2	5563	broad.mit.edu	37	1	57159326	57159326	+	Intron	DEL	A	-	-	rs72195100		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:57159326delA	uc001cyk.3	+							NM_006252	NP_006243			AMP-activated protein kinase alpha 2 catalytic						carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(4)|ovary(1)|stomach(1)	6																		---	---	---	---
PRKAA2	5563	broad.mit.edu	37	1	57173341	57173341	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:57173341delT	uc001cyk.3	+	9	1685	c.1614delT	c.(1612-1614)GATfs	p.D538fs		NM_006252	NP_006243	P54646	AAPK2_HUMAN	AMP-activated protein kinase alpha 2 catalytic	538					carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(4)|ovary(1)|stomach(1)	6																		---	---	---	---
CYP2J2	1573	broad.mit.edu	37	1	60370505	60370505	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:60370505delC	uc001czq.2	-							NM_000775	NP_000766			cytochrome P450, family 2, subfamily J,						epoxygenase P450 pathway|linoleic acid metabolic process|regulation of heart contraction|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	arachidonic acid 11,12-epoxygenase activity|arachidonic acid 14,15-epoxygenase activity|aromatase activity|electron carrier activity|heme binding|linoleic acid epoxygenase activity			ovary(1)	1	all_cancers(7;0.000396)																	---	---	---	---
Unknown	0	broad.mit.edu	37	1	62120102	62120103	+	IGR	INS	-	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:62120102_62120103insG								NFIA (191643 upstream) : TM2D1 (26616 downstream)																																			---	---	---	---
ALG6	29929	broad.mit.edu	37	1	63868132	63868141	+	Intron	DEL	TTTTTTTTTT	-	-	rs78992147		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:63868132_63868141delTTTTTTTTTT	uc010oow.1	+						ALG6_uc001daz.2_Intron|ALG6_uc009waj.2_Intron	NM_013339	NP_037471			dolichyl pyrophosphate Man9GlcNAc2						dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity				0																		---	---	---	---
CACHD1	57685	broad.mit.edu	37	1	65141247	65141247	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:65141247delA	uc001dbo.1	+						CACHD1_uc001dbp.1_Intron|CACHD1_uc001dbq.1_Intron|CACHD1_uc010opa.1_Intron	NM_020925	NP_065976			cache domain containing 1						calcium ion transport	integral to membrane				ovary(2)	2																OREG0013544	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
LEPR	3953	broad.mit.edu	37	1	65915368	65915369	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:65915368_65915369delTT	uc001dci.2	+						LEPR_uc001dcg.2_Intron|LEPR_uc001dch.2_Intron|LEPR_uc009waq.2_Intron	NM_002303	NP_002294			leptin receptor isoform 1						energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)														---	---	---	---
LEPR	3953	broad.mit.edu	37	1	66031325	66031325	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:66031325delA	uc001dci.2	+						LEPR_uc001dcg.2_Intron|LEPR_uc001dch.2_Intron|LEPR_uc009waq.2_Intron|LEPR_uc001dcj.2_Intron|LEPR_uc001dck.2_Intron	NM_002303	NP_002294			leptin receptor isoform 1						energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)														---	---	---	---
LEPR	3953	broad.mit.edu	37	1	66071026	66071026	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:66071026delA	uc001dci.2	+						LEPR_uc001dcg.2_Intron|LEPR_uc001dch.2_Intron|LEPR_uc009waq.2_Intron|LEPR_uc001dcj.2_Intron|LEPR_uc001dck.2_Intron	NM_002303	NP_002294			leptin receptor isoform 1						energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)														---	---	---	---
LEPR	3953	broad.mit.edu	37	1	66088756	66088756	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:66088756delA	uc001dci.2	+						LEPR_uc001dcg.2_Intron|LEPR_uc001dch.2_Intron|LEPR_uc009waq.2_Intron|LEPR_uc001dcj.2_Intron|LEPR_uc001dck.2_Intron	NM_002303	NP_002294			leptin receptor isoform 1						energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)														---	---	---	---
SGIP1	84251	broad.mit.edu	37	1	67099769	67099769	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:67099769delA	uc001dcr.2	+							NM_032291	NP_115667			SH3-domain GRB2-like (endophilin) interacting						positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			ovary(3)	3																		---	---	---	---
WDR78	79819	broad.mit.edu	37	1	67279867	67279867	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:67279867delA	uc001dcx.2	-						WDR78_uc009waw.2_Intron|WDR78_uc009wax.2_Intron	NM_024763	NP_079039			WD repeat domain 78 isoform 1											ovary(2)	2																		---	---	---	---
IL12RB2	3595	broad.mit.edu	37	1	67833438	67833438	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:67833438delT	uc001ddu.2	+						IL12RB2_uc010oqi.1_Intron|IL12RB2_uc010oqj.1_Intron|IL12RB2_uc010oqk.1_Intron|IL12RB2_uc010oql.1_Intron|IL12RB2_uc010oqm.1_Intron|IL12RB2_uc010oqn.1_Intron	NM_001559	NP_001550			interleukin 12 receptor, beta 2 precursor						positive regulation of cell proliferation|positive regulation of interferon-gamma production	integral to plasma membrane	cytokine receptor activity			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
RPE65	6121	broad.mit.edu	37	1	68917241	68917242	+	5'Flank	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:68917241_68917242delTT	uc001dei.1	-							NM_000329	NP_000320			retinal pigment epithelium-specific protein						visual perception	cytoplasm|plasma membrane	all-trans-retinyl-palmitate hydrolase activity|metal ion binding|retinol isomerase activity			ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	1	72969498	72969499	+	IGR	INS	-	CTCC	CTCC	rs146980338	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:72969498_72969499insCTCC								NEGR1 (221093 upstream) : None (None downstream)																																			---	---	---	---
TNNI3K	51086	broad.mit.edu	37	1	74715031	74715031	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:74715031delA	uc001dgf.1	+						TNNI3K_uc001dgc.1_Intron|TNNI3K_uc001dgd.2_Intron|TNNI3K_uc001dge.1_Intron	NM_015978	NP_057062			TNNI3 interacting kinase isoform b							cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding			large_intestine(4)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)	10																		---	---	---	---
TNNI3K	51086	broad.mit.edu	37	1	74929045	74929046	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:74929045_74929046delTT	uc001dgf.1	+						TNNI3K_uc001dgd.2_Intron|TNNI3K_uc001dge.1_Intron	NM_015978	NP_057062			TNNI3 interacting kinase isoform b							cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding			large_intestine(4)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)	10																		---	---	---	---
CRYZ	1429	broad.mit.edu	37	1	75185185	75185187	+	Intron	DEL	TTT	-	-	rs72258036		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:75185185_75185187delTTT	uc001dgk.2	-						CRYZ_uc001dgj.2_Intron|CRYZ_uc001dgl.2_Intron|CRYZ_uc001dgm.2_Intron	NM_001130042	NP_001123514			crystallin, zeta isoform a						protein homotetramerization|visual perception|xenobiotic catabolic process	cytosol|Golgi apparatus	mRNA 3'-UTR binding|NADPH binding|NADPH:quinone reductase activity|zinc ion binding				0					Dicumarol(DB00266)													---	---	---	---
SLC44A5	204962	broad.mit.edu	37	1	76084764	76084765	+	Intron	DEL	AG	-	-	rs141643516	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:76084764_76084765delAG	uc010oqz.1	-						SLC44A5_uc010orb.1_Intron	NM_001130058	NP_001123530			solute carrier family 44, member 5 isoform B							integral to membrane|plasma membrane	choline transmembrane transporter activity			ovary(2)|skin(2)	4																		---	---	---	---
USP33	23032	broad.mit.edu	37	1	78188044	78188045	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:78188044_78188045delAA	uc001dht.2	-						USP33_uc001dhs.2_Intron|USP33_uc001dhu.2_Intron|USP33_uc001dhv.2_Intron|USP33_uc001dhw.2_Intron	NM_015017	NP_055832			ubiquitin specific protease 33 isoform 1						axon guidance|cell migration|endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|VCB complex	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(2)|ovary(1)	3																		---	---	---	---
NEXN	91624	broad.mit.edu	37	1	78383226	78383226	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:78383226delT	uc001dic.3	+						NEXN_uc001dia.3_Intron|NEXN_uc009wcb.1_Intron|NEXN_uc001dib.3_Intron|NEXN_uc001did.1_5'Flank|NEXN_uc001dif.1_5'Flank	NM_144573	NP_653174			nexilin (F actin binding protein)						regulation of cell migration|regulation of cytoskeleton organization	cytoskeleton|Z disc	actin filament binding|structural constituent of muscle			ovary(2)	2				Colorectal(170;0.114)														---	---	---	---
GIPC2	54810	broad.mit.edu	37	1	78509970	78509970	+	5'Flank	DEL	T	-	-	rs112459517		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:78509970delT	uc001dik.2	+							NM_017655	NP_060125			PDZ domain protein GIPC2							cytoplasm				ovary(1)	1																		---	---	---	---
GIPC2	54810	broad.mit.edu	37	1	78560481	78560481	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:78560481delT	uc001dik.2	+							NM_017655	NP_060125			PDZ domain protein GIPC2							cytoplasm				ovary(1)	1																		---	---	---	---
SSX2IP	117178	broad.mit.edu	37	1	85123941	85123941	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:85123941delA	uc001dkh.2	-						SSX2IP_uc001dkf.2_Intron|SSX2IP_uc001dkg.2_Intron|SSX2IP_uc010orz.1_Intron|SSX2IP_uc001dki.2_Intron|SSX2IP_uc010osa.1_Intron|SSX2IP_uc001dkj.2_Intron|SSX2IP_uc009wci.2_Intron|SSX2IP_uc001dkk.1_Intron	NM_014021	NP_054740			synovial sarcoma, X breakpoint 2 interacting						cell adhesion	nucleus|protein complex				ovary(2)	2				all cancers(265;0.0053)|Epithelial(280;0.0214)|OV - Ovarian serous cystadenocarcinoma(397;0.173)														---	---	---	---
MCOLN2	255231	broad.mit.edu	37	1	85403564	85403564	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:85403564delA	uc001dkm.2	-						MCOLN2_uc001dkn.2_Intron	NM_153259	NP_694991			mucolipin 2							integral to membrane	ion channel activity			ovary(3)|upper_aerodigestive_tract(1)	4				all cancers(265;0.0111)|Epithelial(280;0.0263)|OV - Ovarian serous cystadenocarcinoma(397;0.217)														---	---	---	---
MCOLN3	55283	broad.mit.edu	37	1	85510739	85510739	+	Intron	DEL	A	-	-	rs79389367	byFrequency;by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:85510739delA	uc001dkp.2	-						MCOLN3_uc001dkq.2_Intron|MCOLN3_uc001dkr.2_Intron|MCOLN3_uc001dks.3_Intron	NM_018298	NP_060768			mucolipin 3							integral to membrane	ion channel activity			skin(1)	1				all cancers(265;0.00957)|Epithelial(280;0.0254)														---	---	---	---
C1orf52	148423	broad.mit.edu	37	1	85724508	85724508	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:85724508delT	uc001dkv.2	-						C1orf52_uc001dkw.2_Intron|C1orf52_uc001dkx.3_Intron|C1orf52_uc009wcn.2_Intron	NM_198077	NP_932343			hypothetical protein LOC148423											ovary(1)	1				all cancers(265;0.0105)|Epithelial(280;0.0293)														---	---	---	---
CLCA2	9635	broad.mit.edu	37	1	86891197	86891197	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:86891197delA	uc001dlr.3	+							NM_006536	NP_006527			chloride channel accessory 2 precursor						cell adhesion	basal plasma membrane|cell junction|extracellular region|integral to plasma membrane	chloride channel activity			ovary(1)|breast(1)|skin(1)	3		Lung NSC(277;0.238)		all cancers(265;0.0233)|Epithelial(280;0.0452)														---	---	---	---
CLCA4	22802	broad.mit.edu	37	1	87044938	87044938	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:87044938delT	uc009wcs.2	+						CLCA4_uc009wct.2_Intron|CLCA4_uc009wcu.2_Intron	NM_012128	NP_036260			chloride channel accessory 4							apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			ovary(2)	2		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)														---	---	---	---
HS2ST1	9653	broad.mit.edu	37	1	87563396	87563396	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:87563396delA	uc010osk.1	+						HS2ST1_uc001dmc.3_Intron|LOC339524_uc001dme.1_Intron	NM_012262	NP_036394			heparan sulfate 2-O-sulfotransferase 1 isoform							Golgi membrane|integral to membrane				central_nervous_system(1)	1		Lung NSC(277;0.153)		all cancers(265;0.00699)|Epithelial(280;0.0261)														---	---	---	---
HFM1	164045	broad.mit.edu	37	1	91817007	91817007	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:91817007delA	uc001doa.3	-						HFM1_uc009wdb.2_Intron|HFM1_uc010osu.1_Intron|HFM1_uc010osv.1_Intron	NM_001017975	NP_001017975			HFM1 protein								ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)														---	---	---	---
FNBP1L	54874	broad.mit.edu	37	1	93965150	93965150	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:93965150delT	uc001dpw.2	+						FNBP1L_uc001dpv.2_Intron	NM_001024948	NP_001020119			formin binding protein 1-like isoform 1						endocytosis	cell cortex|cytoplasmic membrane-bounded vesicle|cytoskeleton|plasma membrane	lipid binding				0		all_lung(203;0.00206)|Lung NSC(277;0.00902)|Melanoma(281;0.155)		all cancers(265;0.00666)|GBM - Glioblastoma multiforme(16;0.0378)|Epithelial(280;0.111)														---	---	---	---
ABCA4	24	broad.mit.edu	37	1	94487309	94487309	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:94487309delT	uc001dqh.2	-							NM_000350	NP_000341			ATP-binding cassette, sub-family A member 4						phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)														---	---	---	---
ABCA4	24	broad.mit.edu	37	1	94510447	94510447	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:94510447delC	uc001dqh.2	-							NM_000350	NP_000341			ATP-binding cassette, sub-family A member 4						phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)														---	---	---	---
PTBP2	58155	broad.mit.edu	37	1	97243528	97243528	+	Intron	DEL	T	-	-	rs35880836		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:97243528delT	uc001drq.2	+						PTBP2_uc001drn.2_Intron|PTBP2_uc001dro.2_Intron|PTBP2_uc010otz.1_Intron|PTBP2_uc001drp.2_Intron|PTBP2_uc009wdw.2_Intron|PTBP2_uc001drr.2_Intron|PTBP2_uc010oua.1_Intron|PTBP2_uc001dru.2_Intron	NM_021190	NP_067013			polypyrimidine tract binding protein 2								nucleotide binding				0		all_epithelial(167;2.95e-05)|all_lung(203;0.000396)|Lung NSC(277;0.00171)		all cancers(265;0.0582)|Epithelial(280;0.0716)|Colorectal(170;0.0879)|KIRC - Kidney renal clear cell carcinoma(1967;0.202)														---	---	---	---
DPYD	1806	broad.mit.edu	37	1	97771791	97771791	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:97771791delA	uc001drv.2	-	17	2258	c.2121delT	c.(2119-2121)TTTfs	p.F707fs		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	707					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)													---	---	---	---
FRRS1	391059	broad.mit.edu	37	1	100212750	100212750	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:100212750delG	uc001dsh.1	-							NM_001013660	NP_001013682			stromal cell derived factor receptor 2 homolog						electron transport chain|transport	integral to membrane	ferric-chelate reductase activity|metal ion binding			skin(1)	1		all_epithelial(167;2.09e-06)|all_lung(203;0.000435)|Lung NSC(277;0.00201)		Epithelial(280;0.0718)|all cancers(265;0.126)|COAD - Colon adenocarcinoma(174;0.148)|Lung(183;0.206)														---	---	---	---
CCDC76	54482	broad.mit.edu	37	1	100602758	100602758	+	Intron	DEL	T	-	-	rs79825452		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:100602758delT	uc001dsv.2	+						CCDC76_uc010ouf.1_Intron|CCDC76_uc009wea.2_Intron	NM_019083	NP_061956			coiled-coil domain containing 76						tRNA processing		metal ion binding|methyltransferase activity			ovary(1)	1		all_epithelial(167;0.000542)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0814)|all cancers(265;0.133)|COAD - Colon adenocarcinoma(174;0.146)|Lung(183;0.194)														---	---	---	---
DBT	1629	broad.mit.edu	37	1	100706219	100706219	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:100706219delT	uc001dta.2	-						DBT_uc010oug.1_Intron	NM_001918	NP_001909			dihydrolipoamide branched chain transacylase						branched chain family amino acid catabolic process|fatty-acyl-CoA biosynthetic process	microtubule cytoskeleton|mitochondrial alpha-ketoglutarate dehydrogenase complex|mitochondrial nucleoid	acyltransferase activity|cofactor binding|dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity|protein binding			pancreas(1)	1		all_epithelial(167;5.4e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0739)|all cancers(265;0.123)|COAD - Colon adenocarcinoma(174;0.154)|Lung(183;0.199)														---	---	---	---
CDC14A	8556	broad.mit.edu	37	1	100921054	100921054	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:100921054delT	uc001dtg.3	+						CDC14A_uc009web.2_Intron|CDC14A_uc010oui.1_Intron|CDC14A_uc001dte.3_Intron|CDC14A_uc001dtf.2_Intron|CDC14A_uc009wed.1_Intron|CDC14A_uc009wee.2_Intron	NM_003672	NP_003663			CDC14 homolog A isoform 1						cell cycle|cell division|cell proliferation	centrosome|nucleus|spindle	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			large_intestine(1)	1		all_epithelial(167;3.71e-06)|all_lung(203;0.00097)|Lung NSC(277;0.001)		Epithelial(280;0.0676)|all cancers(265;0.127)|COAD - Colon adenocarcinoma(174;0.201)|Lung(183;0.227)|Colorectal(144;0.241)														---	---	---	---
Unknown	0	broad.mit.edu	37	1	102251813	102251813	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:102251813delT								S1PR1 (544737 upstream) : OLFM3 (16314 downstream)																																			---	---	---	---
COL11A1	1301	broad.mit.edu	37	1	103352710	103352711	+	Intron	DEL	GT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:103352710_103352711delGT	uc001dul.2	-						COL11A1_uc001duk.2_Intron|COL11A1_uc001dum.2_Intron|COL11A1_uc001dun.2_Intron|COL11A1_uc009weh.2_Intron	NM_001854	NP_001845			alpha 1 type XI collagen isoform A						collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)														---	---	---	---
COL11A1	1301	broad.mit.edu	37	1	103444369	103444369	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:103444369delA	uc001dul.2	-						COL11A1_uc001duk.2_Intron|COL11A1_uc001dum.2_Intron|COL11A1_uc001dun.2_Intron|COL11A1_uc009weh.2_Intron	NM_001854	NP_001845			alpha 1 type XI collagen isoform A						collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)														---	---	---	---
Unknown	0	broad.mit.edu	37	1	106435594	106435594	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:106435594delA								None (None upstream) : None (None downstream)																																			---	---	---	---
FNDC7	163479	broad.mit.edu	37	1	109273233	109273233	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:109273233delT	uc001dvx.2	+						FNDC7_uc010ova.1_Intron	NM_001144937	NP_001138409			fibronectin type III domain containing 7							extracellular region				ovary(1)|skin(1)	2		all_lung(203;0.00439)|Lung NSC(277;0.00683)|all_epithelial(167;0.00728)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.173)|all cancers(265;0.244)														---	---	---	---
TAF13	6884	broad.mit.edu	37	1	109608915	109608915	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:109608915delA	uc001dwm.1	-							NM_005645	NP_005636			TBP-associated factor 13						transcription elongation from RNA polymerase II promoter|viral reproduction	transcription factor TFIID complex	protein C-terminus binding|sequence-specific DNA binding transcription factor activity				0		all_epithelial(167;0.000102)|all_lung(203;0.000321)|Lung NSC(277;0.000626)		Colorectal(144;0.0138)|Lung(183;0.0425)|COAD - Colon adenocarcinoma(174;0.113)|Epithelial(280;0.166)|all cancers(265;0.191)|LUSC - Lung squamous cell carcinoma(189;0.228)														---	---	---	---
MYBPHL	343263	broad.mit.edu	37	1	109836686	109836686	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:109836686delA	uc001dxk.1	-						MYBPHL_uc010ovh.1_Intron|MYBPHL_uc001dxl.2_Intron	NM_001010985	NP_001010985			myosin binding protein H-like											ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(203;0.00519)|all_epithelial(167;0.00575)|Lung NSC(277;0.00822)		Colorectal(144;0.0306)|Lung(183;0.0681)|COAD - Colon adenocarcinoma(174;0.117)|Epithelial(280;0.197)|all cancers(265;0.225)														---	---	---	---
SORT1	6272	broad.mit.edu	37	1	109883200	109883200	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:109883200delA	uc001dxm.1	-						SORT1_uc010ovi.1_Intron	NM_002959	NP_002950			sortilin 1 preproprotein						endocytosis|endosome to lysosome transport|endosome transport via multivesicular body sorting pathway|glucose import|Golgi to endosome transport|induction of apoptosis by extracellular signals|myotube differentiation|negative regulation of apoptosis|negative regulation of lipoprotein lipase activity|neuropeptide signaling pathway|ossification|plasma membrane to endosome transport|regulation of gene expression|response to insulin stimulus|vesicle organization	cell surface|coated pit|early endosome|endoplasmic reticulum membrane|endosome membrane|Golgi cisterna membrane|integral to membrane|lysosomal membrane|microsome|nuclear membrane|perinuclear region of cytoplasm|plasma membrane	enzyme binding|nerve growth factor binding|nerve growth factor receptor activity|neurotensin receptor activity, non-G-protein coupled			ovary(1)	1		all_epithelial(167;4.69e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0529)|Colorectal(144;0.142)|Epithelial(280;0.145)|Kidney(133;0.169)|all cancers(265;0.184)														---	---	---	---
GNAI3	2773	broad.mit.edu	37	1	110129583	110129584	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:110129583_110129584delTT	uc001dxz.2	+							NM_006496	NP_006487			guanine nucleotide binding protein (G protein),						cell cycle|cell division|inhibition of adenylate cyclase activity by G-protein signaling pathway|platelet activation|synaptic transmission	centrosome|heterotrimeric G-protein complex|midbody	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|metabotropic serotonin receptor binding|signal transducer activity			ovary(1)	1		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.046)|Colorectal(144;0.119)|Epithelial(280;0.139)|all cancers(265;0.147)|LUSC - Lung squamous cell carcinoma(189;0.237)														---	---	---	---
ST7L	54879	broad.mit.edu	37	1	113119748	113119748	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:113119748delA	uc001ecd.2	-						ST7L_uc009wgh.2_Intron|ST7L_uc001ecc.2_Intron|ST7L_uc010owg.1_Intron|ST7L_uc010owh.1_Intron|ST7L_uc001ece.2_Intron|ST7L_uc001ecf.2_Intron|ST7L_uc001ecg.2_Intron|ST7L_uc010owi.1_Intron|ST7L_uc001ech.2_Intron|ST7L_uc001eci.2_Intron|ST7L_uc009wgi.1_Intron|ST7L_uc010owj.1_Intron	NM_017744	NP_060214			suppression of tumorigenicity 7-like isoform 1						negative regulation of cell growth	integral to membrane	binding				0	Lung SC(450;0.246)	all_cancers(81;1.44e-07)|all_epithelial(167;7.64e-07)|all_lung(203;2.16e-05)|Lung NSC(69;3.86e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)														---	---	---	---
CAPZA1	829	broad.mit.edu	37	1	113212124	113212124	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:113212124delA	uc001ecj.1	+							NM_006135	NP_006126			F-actin capping protein alpha-1 subunit						actin cytoskeleton organization|actin filament capping|blood coagulation|cellular component movement|innate immune response|protein complex assembly	cytosol|extracellular region|F-actin capping protein complex|WASH complex	actin binding				0	Lung SC(450;0.246)	all_cancers(81;1.44e-07)|all_epithelial(167;7.64e-07)|all_lung(203;2.16e-05)|Lung NSC(69;3.86e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)														---	---	---	---
LRIG2	9860	broad.mit.edu	37	1	113635953	113635953	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:113635953delT	uc001edf.1	+						LRIG2_uc009wgn.1_Intron	NM_014813	NP_055628			leucine-rich repeats and immunoglobulin-like							cytoplasm|integral to membrane|plasma membrane				ovary(3)	3	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)														---	---	---	---
PTPN22	26191	broad.mit.edu	37	1	114377352	114377352	+	Intron	DEL	A	-	-	rs79608028		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:114377352delA	uc001eds.2	-						PTPN22_uc009wgq.2_Intron|PTPN22_uc010owo.1_Intron|PTPN22_uc001edt.2_Intron|PTPN22_uc009wgr.2_Intron|PTPN22_uc009wgs.2_Intron|PTPN22_uc001edu.2_Intron	NM_015967	NP_057051			protein tyrosine phosphatase, non-receptor type						negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			kidney(2)|lung(1)|skin(1)	4	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)														---	---	---	---
CSDE1	7812	broad.mit.edu	37	1	115279333	115279333	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:115279333delA	uc001efk.2	-						CSDE1_uc001efi.2_Intron|CSDE1_uc001efj.2_Intron|CSDE1_uc001efl.2_Intron|CSDE1_uc001efm.2_Intron|CSDE1_uc009wgv.2_Intron|CSDE1_uc001efn.2_Intron	NM_001007553	NP_001007554			upstream of NRAS isoform 1						male gonad development|regulation of transcription, DNA-dependent	cytoplasm	DNA binding|protein binding|RNA binding			ovary(1)	1	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;2.21e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)														---	---	---	---
IGSF3	3321	broad.mit.edu	37	1	117158604	117158604	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:117158604delT	uc001egr.1	-						IGSF3_uc001egq.1_Intron	NM_001007237	NP_001007238			immunoglobulin superfamily, member 3 isoform 2							integral to membrane				ovary(2)	2	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)														---	---	---	---
WDR3	10885	broad.mit.edu	37	1	118502088	118502088	+	3'UTR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:118502088delT	uc010oxe.1	+	27					WDR3_uc001ehi.2_Intron|SPAG17_uc001ehk.2_Intron	NM_006784	NP_006775			WD repeat-containing protein 3							nuclear membrane|nucleolus				upper_aerodigestive_tract(1)	1	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)														---	---	---	---
SPAG17	200162	broad.mit.edu	37	1	118644661	118644661	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:118644661delT	uc001ehk.2	-							NM_206996	NP_996879			sperm associated antigen 17							cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)														---	---	---	---
HSD3B1	3283	broad.mit.edu	37	1	120049947	120049947	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:120049947delA	uc001ehv.1	+						HSD3B1_uc001ehw.2_5'UTR	NM_000862	NP_000853			3 beta-hydroxysteroid dehydrogenase 1						androgen biosynthetic process|estrogen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			ovary(2)	2	all_neural(166;0.219)	all_lung(203;3.16e-06)|Lung NSC(69;2.19e-05)|all_epithelial(167;0.000624)		Lung(183;0.0106)|LUSC - Lung squamous cell carcinoma(189;0.0554)	NADH(DB00157)|Trilostane(DB01108)													---	---	---	---
NOTCH2	4853	broad.mit.edu	37	1	120480399	120480399	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:120480399delA	uc001eik.2	-						NOTCH2_uc001eil.2_Intron	NM_024408	NP_077719			notch 2 preproprotein						anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)				N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				---	---	---	---
Unknown	0	broad.mit.edu	37	1	143223671	143223672	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:143223671_143223672insT	uc001eiw.1	+											Homo sapiens PNAS-130 mRNA, complete cds.																														---	---	---	---
NBPF9	400818	broad.mit.edu	37	1	144617269	144617269	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:144617269delG	uc009wig.1	+						NBPF9_uc010oxn.1_Intron|NBPF9_uc010oxo.1_Intron|NBPF9_uc010oxr.1_Intron|NBPF9_uc010oxt.1_Intron|NBPF9_uc001ekg.1_Intron|NBPF9_uc001ekk.1_Intron|NBPF10_uc009wir.2_Intron|NBPF9_uc010oyd.1_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc001eli.3_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF9_uc009wii.1_Intron	NM_001037675	NP_001032764			hypothetical protein LOC400818							cytoplasm					0																		---	---	---	---
NBPF10	100132406	broad.mit.edu	37	1	145209324	145209332	+	5'UTR	DEL	GGCGGCGGC	-	-	rs72083240	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:145209324_145209332delGGCGGCGGC	uc001emp.3	+	1					NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NOTCH2NL_uc001emn.3_5'UTR|NOTCH2NL_uc001emm.3_5'UTR|NOTCH2NL_uc001emo.2_5'UTR|NOTCH2NL_uc010oyh.1_RNA	NM_017940	NP_060410			hypothetical protein LOC55672												0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)														---	---	---	---
NBPF10	100132406	broad.mit.edu	37	1	145327390	145327390	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:145327390delT	uc001end.3	+						NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_Intron|NBPF10_uc010oyl.1_Intron|NBPF10_uc001enc.2_Intron|NBPF10_uc010oym.1_Intron|NBPF10_uc010oyn.1_Intron|NBPF10_uc010oyo.1_Intron|NBPF10_uc010oyp.1_Intron	NM_001039703	NP_001034792			hypothetical protein LOC100132406												0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)														---	---	---	---
ITGA10	8515	broad.mit.edu	37	1	145527998	145527998	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:145527998delG	uc001eoa.2	+	3	311	c.235delG	c.(235-237)GGGfs	p.G79fs	NBPF10_uc001emp.3_Intron|ITGA10_uc001enz.1_Frame_Shift_Del_p.G79fs|ITGA10_uc010oyv.1_Intron|ITGA10_uc009wiw.2_Intron|ITGA10_uc010oyw.1_Frame_Shift_Del_p.G24fs	NM_003637	NP_003628	O75578	ITA10_HUMAN	integrin, alpha 10 precursor	79	Extracellular (Potential).|FG-GAP 1.				cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			lung(2)|ovary(2)|kidney(2)|large_intestine(1)|skin(1)	8	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)																	---	---	---	---
NBPF10	100132406	broad.mit.edu	37	1	145559919	145559920	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:145559919_145559920delAA	uc001emp.3	+						ANKRD35_uc010oyx.1_Intron|ANKRD35_uc001eob.1_Intron	NM_017940	NP_060410			hypothetical protein LOC55672												0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)														---	---	---	---
Unknown	0	broad.mit.edu	37	1	146587192	146587192	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:146587192delA								LOC728989 (72593 upstream) : PRKAB2 (39495 downstream)																																			---	---	---	---
VPS45	11311	broad.mit.edu	37	1	150082514	150082514	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:150082514delA	uc001etp.2	+						VPS45_uc010pbp.1_Intron|VPS45_uc010pbq.1_Intron|VPS45_uc010pbs.1_Intron|VPS45_uc001etq.2_Intron	NM_007259	NP_009190			vacuolar protein sorting 45A						blood coagulation|intracellular protein transport|vesicle docking involved in exocytosis	endosome membrane|Golgi membrane|integral to membrane of membrane fraction				central_nervous_system(1)|skin(1)	2	Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)															---	---	---	---
TARS2	80222	broad.mit.edu	37	1	150462895	150462895	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:150462895delT	uc001euq.2	+						TARS2_uc010pcd.1_Intron|TARS2_uc001eur.2_Intron|TARS2_uc009wlt.2_Intron|TARS2_uc009wls.2_Intron	NM_025150	NP_079426			threonyl-tRNA synthetase 2, mitochondrial						threonyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|threonine-tRNA ligase activity			ovary(1)	1	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.51e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)		L-Threonine(DB00156)													---	---	---	---
CTSK	1513	broad.mit.edu	37	1	150778663	150778663	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:150778663delT	uc001evp.1	-	3	282	c.158delA	c.(157-159)AACfs	p.N53fs	CTSK_uc001evq.1_5'UTR|CTSK_uc009wma.1_RNA	NM_000396	NP_000387	P43235	CATK_HUMAN	cathepsin K preproprotein	53					proteolysis	lysosome	cysteine-type endopeptidase activity|protein binding			skin(1)	1	all_cancers(9;2.32e-51)|all_epithelial(9;3.89e-42)|all_lung(15;4.59e-35)|Lung NSC(24;1.7e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Colorectal(459;0.171)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0485)|BRCA - Breast invasive adenocarcinoma(12;0.00606)|LUSC - Lung squamous cell carcinoma(543;0.211)															---	---	---	---
SETDB1	9869	broad.mit.edu	37	1	150931598	150931598	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:150931598delT	uc001evu.2	+						SETDB1_uc001evv.2_Intron|SETDB1_uc009wmg.1_Intron	NM_001145415	NP_001138887			SET domain, bifurcated 1 isoform 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)															---	---	---	---
SETDB1	9869	broad.mit.edu	37	1	150935850	150935850	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:150935850delA	uc001evu.2	+						SETDB1_uc001evv.2_Intron|SETDB1_uc009wmg.1_Intron	NM_001145415	NP_001138887			SET domain, bifurcated 1 isoform 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)															---	---	---	---
FAM63A	55793	broad.mit.edu	37	1	150972560	150972560	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:150972560delT	uc001ewf.2	-						FAM63A_uc001ewc.2_Intron|FAM63A_uc010pcm.1_Intron|FAM63A_uc001ewd.2_Intron|FAM63A_uc001ewe.2_Intron|FAM63A_uc010pcn.1_Intron|FAM63A_uc001ewg.2_Intron	NM_018379	NP_001156731			hypothetical protein LOC55793 isoform 1								protein binding			ovary(1)	1	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)															---	---	---	---
FAM63A	55793	broad.mit.edu	37	1	150974465	150974466	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:150974465_150974466delTT	uc001ewf.2	-						FAM63A_uc001ewc.2_Intron|FAM63A_uc010pcm.1_Intron|FAM63A_uc001ewd.2_Intron|FAM63A_uc001ewe.2_Intron|FAM63A_uc010pcn.1_Intron|FAM63A_uc001ewg.2_Intron	NM_018379	NP_001156731			hypothetical protein LOC55793 isoform 1								protein binding			ovary(1)	1	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)															---	---	---	---
PRUNE	58497	broad.mit.edu	37	1	150990220	150990220	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:150990220delA	uc001ewh.1	+						PRUNE_uc001ewi.1_Intron|PRUNE_uc010pco.1_Intron|PRUNE_uc001ewj.1_Intron	NM_021222	NP_067045			prune							cytoplasm|focal adhesion|nucleus	inorganic diphosphatase activity|manganese ion binding|protein binding			ovary(1)	1	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)															---	---	---	---
PIP5K1A	8394	broad.mit.edu	37	1	151204866	151204867	+	Intron	DEL	TG	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:151204866_151204867delTG	uc001exj.2	+						PIP5K1A_uc001exi.2_Intron|PIP5K1A_uc010pcu.1_Intron|PIP5K1A_uc001exk.2_Intron|PIP5K1A_uc010pcv.1_5'Flank	NM_001135638	NP_001129110			phosphatidylinositol-4-phosphate 5-kinase, type						phospholipid biosynthetic process|signal transduction	endomembrane system|Golgi stack|lamellipodium|nuclear speck	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|kinase binding			ovary(1)|central_nervous_system(1)|skin(1)	3	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.181)															---	---	---	---
NPR1	4881	broad.mit.edu	37	1	153665420	153665420	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:153665420delG	uc001fcs.3	+						NPR1_uc010pdz.1_Intron|NPR1_uc010pea.1_Intron	NM_000906	NP_000897			natriuretic peptide receptor 1 precursor						body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			ovary(3)|lung(2)|stomach(1)|breast(1)	7	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)													---	---	---	---
NUP210L	91181	broad.mit.edu	37	1	153974466	153974466	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:153974466delA	uc001fdw.2	-						NUP210L_uc009woq.2_Intron|NUP210L_uc010peh.1_Intron	NM_207308	NP_997191			nucleoporin 210kDa-like isoform 1							integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)															---	---	---	---
NUP210L	91181	broad.mit.edu	37	1	154002614	154002614	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:154002614delT	uc001fdw.2	-						NUP210L_uc009woq.2_Intron|NUP210L_uc010peh.1_Intron	NM_207308	NP_997191			nucleoporin 210kDa-like isoform 1							integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)															---	---	---	---
NUP210L	91181	broad.mit.edu	37	1	154067526	154067526	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:154067526delA	uc001fdw.2	-	15	2144	c.2072delT	c.(2071-2073)TTGfs	p.L691fs	NUP210L_uc009woq.2_5'UTR|NUP210L_uc010peh.1_Frame_Shift_Del_p.L691fs	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	691						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)															---	---	---	---
NUP210L	91181	broad.mit.edu	37	1	154090061	154090061	+	Intron	DEL	A	-	-	rs79748906		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:154090061delA	uc001fdw.2	-						NUP210L_uc009woq.2_Intron|NUP210L_uc010peh.1_Intron	NM_207308	NP_997191			nucleoporin 210kDa-like isoform 1							integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)															---	---	---	---
SHC1	6464	broad.mit.edu	37	1	154942911	154942911	+	Frame_Shift_Del	DEL	G	-	-	rs115641580	byFrequency	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:154942911delG	uc001ffv.2	-	1	313	c.92delC	c.(91-93)CCGfs	p.P31fs	SHC1_uc001ffz.1_5'Flank|SHC1_uc001ffw.2_Frame_Shift_Del_p.P31fs|SHC1_uc001ffx.2_Intron|SHC1_uc001ffy.2_Intron	NM_183001	NP_892113	P29353	SHC1_HUMAN	SHC-transforming protein 1 isoform 1	31					activation of MAPK activity|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|positive regulation of DNA replication|Ras protein signal transduction|regulation of epidermal growth factor receptor activity|regulation of growth	cytosol|mitochondrial matrix|Shc-EGFR complex	epidermal growth factor receptor binding|insulin receptor binding|insulin-like growth factor receptor binding|phospholipid binding|protein binding|transmembrane receptor protein tyrosine kinase adaptor activity			lung(1)|skin(1)	2	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)															---	---	---	---
DCST2	127579	broad.mit.edu	37	1	154996261	154996262	+	Intron	INS	-	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:154996261_154996262insG	uc001fgm.2	-						DCST2_uc009wpb.2_Intron	NM_144622	NP_653223			DC-STAMP domain containing 2							integral to membrane				ovary(2)|central_nervous_system(1)	3	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)															---	---	---	---
MTX1	4580	broad.mit.edu	37	1	155180006	155180006	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:155180006delT	uc001fjb.2	+						RAG1AP1_uc010pey.1_Intron|THBS3_uc001fix.2_5'Flank|THBS3_uc009wqi.2_5'Flank|THBS3_uc001fiz.2_5'Flank|THBS3_uc001fiy.2_5'Flank|THBS3_uc010pfu.1_5'Flank|THBS3_uc010pfv.1_5'Flank|THBS3_uc001fja.2_5'Flank|THBS3_uc009wqj.1_5'Flank|MTX1_uc001fjc.2_Intron	NM_002455	NP_002446			metaxin 1 isoform 1						protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane	protein binding			skin(1)	1	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)															---	---	---	---
ASH1L	55870	broad.mit.edu	37	1	155365459	155365459	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:155365459delA	uc009wqq.2	-						ASH1L_uc001fkt.2_Intron	NM_018489	NP_060959			absent, small, or homeotic 1-like						cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)															---	---	---	---
ASH1L	55870	broad.mit.edu	37	1	155448019	155448019	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:155448019delT	uc009wqq.2	-	3	5122	c.4642delA	c.(4642-4644)AGCfs	p.S1548fs	ASH1L_uc001fkt.2_Frame_Shift_Del_p.S1548fs|ASH1L_uc009wqr.1_Frame_Shift_Del_p.S1548fs	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	1548					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)															---	---	---	---
YY1AP1	55249	broad.mit.edu	37	1	155644954	155644954	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:155644954delT	uc001fln.2	-						YY1AP1_uc010pgg.1_Intron|YY1AP1_uc010pgh.1_Intron|YY1AP1_uc010pgi.1_Intron|YY1AP1_uc001flh.2_Intron|YY1AP1_uc009wqt.2_Intron|YY1AP1_uc001flk.2_Intron|YY1AP1_uc001fll.2_Intron|YY1AP1_uc009wqv.2_Intron|YY1AP1_uc001flm.2_Intron|YY1AP1_uc001fli.2_Intron|YY1AP1_uc009wqu.2_Intron|YY1AP1_uc001flj.2_Intron|YY1AP1_uc009wqw.2_Intron|YY1AP1_uc001flo.2_Intron|YY1AP1_uc001flp.2_Intron|YY1AP1_uc010pgj.1_Intron|YY1AP1_uc009wqx.2_Intron|YY1AP1_uc010pgk.1_Intron	NM_139118	NP_620829			YY1-associated protein isoform 2						regulation of cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)																	---	---	---	---
DAP3	7818	broad.mit.edu	37	1	155701653	155701653	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:155701653delA	uc001flq.2	+						DAP3_uc001flr.2_Intron|DAP3_uc001fls.2_Intron|DAP3_uc010pgl.1_Intron|DAP3_uc001flt.2_Intron|DAP3_uc001flu.2_Intron|DAP3_uc010pgm.1_Intron	NM_033657	NP_387506			death-associated protein 3						induction of apoptosis by extracellular signals	mitochondrial ribosome|nucleolus|small ribosomal subunit	protein binding			ovary(1)	1	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)																	---	---	---	---
SPTA1	6708	broad.mit.edu	37	1	158582498	158582499	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:158582498_158582499delAA	uc001fst.1	-							NM_003126	NP_003117			spectrin, alpha, erythrocytic 1						actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)																	---	---	---	---
CD84	8832	broad.mit.edu	37	1	160549254	160549254	+	5'Flank	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:160549254delA	uc001fwh.3	-						CD84_uc001fwf.3_5'Flank|CD84_uc001fwg.3_5'Flank|CD84_uc009wtn.2_5'Flank|CD84_uc001fwi.3_5'Flank|CD84_uc001fwj.2_5'Flank|CD84_uc001fwk.2_5'Flank	NM_003874	NP_003865			CD84 molecule						blood coagulation|defense response|homophilic cell adhesion|leukocyte migration	integral to plasma membrane	receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(52;3.62e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)															---	---	---	---
GPA33	10223	broad.mit.edu	37	1	167059465	167059465	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:167059465delA	uc001gea.1	-							NM_005814	NP_005805			transmembrane glycoprotein A33 precursor							integral to plasma membrane	receptor activity				0																		---	---	---	---
MPZL1	9019	broad.mit.edu	37	1	167735059	167735059	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:167735059delT	uc001geo.2	+						MPZL1_uc001gen.3_Intron|MPZL1_uc001gep.2_Intron|MPZL1_uc001geq.2_Intron|MPZL1_uc009wvh.2_Intron	NM_003953	NP_003944			myelin protein zero-like 1 isoform a						cell-cell signaling|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	protein binding|structural molecule activity			ovary(2)	2	all_hematologic(923;0.215)																	---	---	---	---
ADCY10	55811	broad.mit.edu	37	1	167865906	167865906	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:167865906delG	uc001ger.2	-	7	964	c.666delC	c.(664-666)CCCfs	p.P222fs	ADCY10_uc009wvk.2_Frame_Shift_Del_p.P130fs|ADCY10_uc010plj.1_Frame_Shift_Del_p.P69fs|ADCY10_uc009wvl.2_Frame_Shift_Del_p.P221fs|ADCY10_uc009wvm.2_RNA	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	222					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3																		---	---	---	---
XCL2	6846	broad.mit.edu	37	1	168513367	168513368	+	5'Flank	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:168513367_168513368delAA	uc001gfn.3	-							NM_003175	NP_003166			chemokine (C motif) ligand 2 precursor						blood circulation|chemotaxis|immune response|signal transduction	extracellular space	chemokine activity			ovary(1)	1	all_hematologic(923;0.215)																	---	---	---	---
BLZF1	8548	broad.mit.edu	37	1	169351458	169351458	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:169351458delA	uc001gfx.1	+	6	1393	c.956delA	c.(955-957)CAAfs	p.Q319fs	BLZF1_uc001gfy.2_Frame_Shift_Del_p.Q319fs|BLZF1_uc009wvp.1_Intron	NM_003666	NP_003657	Q9H2G9	GO45_HUMAN	basic leucine zipper nuclear factor 1	319					cell proliferation|Golgi organization|Golgi to plasma membrane protein transport|regulation of cell growth|regulation of transcription from RNA polymerase II promoter	Golgi lumen|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding			skin(1)	1	all_hematologic(923;0.208)																	---	---	---	---
BLZF1	8548	broad.mit.edu	37	1	169356113	169356113	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:169356113delT	uc001gfx.1	+						BLZF1_uc001gfy.2_Intron|BLZF1_uc009wvp.1_Intron	NM_003666	NP_003657			basic leucine zipper nuclear factor 1						cell proliferation|Golgi organization|Golgi to plasma membrane protein transport|regulation of cell growth|regulation of transcription from RNA polymerase II promoter	Golgi lumen|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding			skin(1)	1	all_hematologic(923;0.208)																	---	---	---	---
C1orf114	57821	broad.mit.edu	37	1	169366387	169366387	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:169366387delT	uc001gga.1	-						C1orf114_uc001gfz.1_Intron|C1orf114_uc009wvq.1_Intron	NM_021179	NP_067002			hypothetical protein LOC57821												0	all_hematologic(923;0.208)																	---	---	---	---
SLC19A2	10560	broad.mit.edu	37	1	169446233	169446236	+	Intron	DEL	TGAA	-	-	rs111564572		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:169446233_169446236delTGAA	uc001gge.3	-						SLC19A2_uc001ggf.3_Intron	NM_006996	NP_008927			solute carrier family 19, member 2						thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|folic acid transporter activity|reduced folate carrier activity|thiamine uptake transmembrane transporter activity				0	all_hematologic(923;0.208)																	---	---	---	---
C1orf112	55732	broad.mit.edu	37	1	169817057	169817057	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:169817057delA	uc001ggp.2	+						C1orf112_uc001ggj.2_Intron|C1orf112_uc001ggq.2_Intron|C1orf112_uc009wvt.2_Intron|C1orf112_uc009wvu.1_Intron|C1orf112_uc001ggr.2_Intron|C1orf112_uc010plv.1_Intron	NM_018186	NP_060656			hypothetical protein LOC55732												0	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)																	---	---	---	---
FMO4	2329	broad.mit.edu	37	1	171288856	171288856	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:171288856delA	uc001gho.2	+							NM_002022	NP_002013			flavin containing monooxygenase 4						xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			kidney(2)|skin(1)	3	all_cancers(6;3.9e-08)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)																	---	---	---	---
Unknown	0	broad.mit.edu	37	1	171652344	171652344	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:171652344delT								MYOC (30521 upstream) : VAMP4 (16954 downstream)																																			---	---	---	---
DNM3	26052	broad.mit.edu	37	1	171890879	171890879	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:171890879delT	uc001gie.2	+						DNM3_uc001gid.3_Intron|DNM3_uc009wwb.2_Intron|DNM3_uc001gif.2_Intron	NM_015569	NP_056384			dynamin 3 isoform a						endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			breast(1)	1																		---	---	---	---
PIGC	5279	broad.mit.edu	37	1	172410733	172410734	+	3'UTR	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:172410733_172410734insT	uc001gil.2	-	2					PIGC_uc001gii.1_Intron|PIGC_uc001gij.1_Intron|C1orf105_uc001gik.2_Intron|PIGC_uc001gin.2_3'UTR|PIGC_uc001gio.2_3'UTR	NM_153747	NP_714969			phosphatidylinositol glycan, class C						C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			lung(1)	1																		---	---	---	---
C1orf9	51430	broad.mit.edu	37	1	172539707	172539708	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:172539707_172539708insA	uc001giq.3	+						C1orf9_uc010pmm.1_Intron|C1orf9_uc009wwd.2_Intron|C1orf9_uc010pmn.1_Intron|C1orf9_uc010pmo.1_Intron	NM_014283	NP_055098			chromosome 1 open reading frame 9 protein						multicellular organismal development|ossification	integral to membrane|rough endoplasmic reticulum membrane				ovary(2)	2		Breast(1374;0.212)		Colorectal(1306;3.98e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00544)														---	---	---	---
Unknown	0	broad.mit.edu	37	1	172718123	172718124	+	IGR	DEL	CT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:172718123_172718124delCT								FASLG (82113 upstream) : TNFSF18 (292236 downstream)																																			---	---	---	---
SLC9A11	284525	broad.mit.edu	37	1	173499213	173499213	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:173499213delA	uc001giz.2	-						SLC9A11_uc009wwe.2_Intron|SLC9A11_uc010pmq.1_Intron	NM_178527	NP_848622			solute carrier family 9, member 11						sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2																		---	---	---	---
RC3H1	149041	broad.mit.edu	37	1	173930702	173930702	+	Intron	DEL	A	-	-	rs71715802		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:173930702delA	uc001gju.3	-						RC3H1_uc010pms.1_Intron|RC3H1_uc001gjv.2_Intron|RC3H1_uc010pmt.1_Intron	NM_172071	NP_742068			roquin						cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2																		---	---	---	---
RFWD2	64326	broad.mit.edu	37	1	175914319	175914319	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:175914319delA	uc001gku.1	-						RFWD2_uc001gkv.1_Intron|RFWD2_uc001gkw.1_Intron|RFWD2_uc009wwv.2_Intron|RFWD2_uc001gkt.1_Intron	NM_022457	NP_071902			ring finger and WD repeat domain 2 isoform a						DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	centrosome|cytosol|focal adhesion|nuclear speck	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0																		---	---	---	---
CEP350	9857	broad.mit.edu	37	1	180031282	180031282	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:180031282delT	uc001gnt.2	+						CEP350_uc009wxl.2_Intron	NM_014810	NP_055625			centrosome-associated protein 350							centrosome|nucleus|spindle				ovary(4)	4																		---	---	---	---
NCF2	4688	broad.mit.edu	37	1	183533129	183533129	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:183533129delA	uc001gqj.3	-						NCF2_uc010pod.1_Intron|NCF2_uc010poe.1_Intron|NCF2_uc001gqk.3_Intron	NM_000433	NP_000424			neutrophil cytosolic factor 2						cellular defense response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex|nucleolus	electron carrier activity|protein C-terminus binding			ovary(3)	3																		---	---	---	---
RGL1	23179	broad.mit.edu	37	1	183775466	183775466	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:183775466delA	uc001gqo.2	+						RGL1_uc010pof.1_Intron|RGL1_uc001gqm.2_Intron|RGL1_uc010pog.1_Intron|RGL1_uc010poh.1_Intron|RGL1_uc010poi.1_Intron	NM_015149	NP_055964			ral guanine nucleotide dissociation						cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|ovary(4)|lung(2)	11																		---	---	---	---
HMCN1	83872	broad.mit.edu	37	1	186057700	186057700	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:186057700delT	uc001grq.1	+							NM_031935	NP_114141			hemicentin 1 precursor						response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23																		---	---	---	---
TPR	7175	broad.mit.edu	37	1	186343827	186343827	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:186343827delT	uc001grv.2	-						C1orf27_uc001grw.2_5'Flank|C1orf27_uc010poq.1_5'Flank|C1orf27_uc010por.1_5'Flank|TPR_uc010pop.1_Intron	NM_003292	NP_003283			nuclear pore complex-associated protein TPR						carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)				T	NTRK1	papillary thyroid								---	---	---	---
PDC	5132	broad.mit.edu	37	1	186415429	186415429	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:186415429delT	uc001gsa.2	-						PDC_uc001grz.2_Intron	NM_002597	NP_002588			phosducin isoform a						G-protein coupled receptor protein signaling pathway|phototransduction|visual perception	actin cytoskeleton|cytosol|nucleus|photoreceptor inner segment|photoreceptor outer segment	phospholipase inhibitor activity			skin(1)	1		Breast(1374;1.53e-05)		KIRC - Kidney renal clear cell carcinoma(1967;3.23e-08)|Colorectal(1306;0.0129)														---	---	---	---
Unknown	0	broad.mit.edu	37	1	192571409	192571409	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:192571409delA								RGS1 (22250 upstream) : RGS13 (33873 downstream)																																			---	---	---	---
RGS2	5997	broad.mit.edu	37	1	192778427	192778427	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:192778427delA	uc001gsl.2	+							NM_002923	NP_002914			regulator of G-protein signaling 2						cell cycle|negative regulation of cardiac muscle hypertrophy|negative regulation of G-protein coupled receptor protein signaling pathway|negative regulation of MAP kinase activity|negative regulation of phospholipase activity|positive regulation of cardiac muscle contraction|regulation of adrenergic receptor signaling pathway|regulation of translation|relaxation of cardiac muscle	cytosol|internal side of plasma membrane|mitochondrion|nucleolus	calmodulin binding|GTPase activator activity|signal transducer activity				0																		---	---	---	---
KCNT2	343450	broad.mit.edu	37	1	196309709	196309709	+	Intron	DEL	A	-	-	rs71639782		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:196309709delA	uc001gtd.1	-						KCNT2_uc009wyt.1_Intron|KCNT2_uc001gte.1_Intron|KCNT2_uc001gtf.1_Intron|KCNT2_uc001gtg.1_Intron|KCNT2_uc009wyu.2_Intron|KCNT2_uc001gth.1_Intron	NM_198503	NP_940905			potassium channel, subfamily T, member 2							voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7																		---	---	---	---
CFH	3075	broad.mit.edu	37	1	196642420	196642420	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:196642420delT	uc001gtj.3	+						CFH_uc001gti.3_Intron|CFH_uc009wyw.2_Intron|CFH_uc009wyx.2_Intron	NM_000186	NP_000177			complement factor H isoform a precursor						complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6																		---	---	---	---
CFHR3	10878	broad.mit.edu	37	1	196759036	196759037	+	Intron	DEL	AG	-	-	rs374905	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:196759036_196759037delAG	uc001gtl.2	+						CFHR3_uc001gtk.2_3'UTR|CFHR3_uc010poy.1_Intron|CFHR1_uc001gtm.2_Intron	NM_021023	NP_066303			complement factor H-related 3 precursor							extracellular space					0																		---	---	---	---
CFHR1	3078	broad.mit.edu	37	1	196797184	196797184	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:196797184delT	uc001gtn.2	+						CFHR1_uc001gtm.2_Intron	NM_002113	NP_002104			complement factor H-related 1 precursor						complement activation	extracellular space					0																		---	---	---	---
ASPM	259266	broad.mit.edu	37	1	197073232	197073232	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:197073232delT	uc001gtu.2	-	18	5406	c.5149delA	c.(5149-5151)ATAfs	p.I1717fs	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	1717					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6																		---	---	---	---
ASPM	259266	broad.mit.edu	37	1	197093847	197093848	+	Intron	DEL	AT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:197093847_197093848delAT	uc001gtu.2	-						ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606			asp (abnormal spindle)-like, microcephaly						mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6																		---	---	---	---
CRB1	23418	broad.mit.edu	37	1	197396479	197396480	+	Intron	INS	-	TG	TG			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:197396479_197396480insTG	uc001gtz.2	+						CRB1_uc010poz.1_Intron|CRB1_uc010ppa.1_Intron|CRB1_uc009wza.2_Intron|CRB1_uc010ppb.1_Intron|CRB1_uc010ppc.1_Intron|CRB1_uc010ppd.1_Intron|CRB1_uc001gub.1_Intron	NM_201253	NP_957705			crumbs homolog 1 precursor						cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9																		---	---	---	---
RPS10P7	376693	broad.mit.edu	37	1	201489731	201489731	+	RNA	DEL	G	-	-	rs4915234	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:201489731delG	uc009wzz.1	+	1		c.1901delG								Homo sapiens cDNA FLJ31028 fis, clone HLUNG2000570, weakly similar to 40S RIBOSOMAL PROTEIN S10.												0																		---	---	---	---
IPO9	55705	broad.mit.edu	37	1	201841933	201841933	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:201841933delT	uc001gwz.2	+							NM_018085	NP_060555			importin 9						protein import into nucleus	cytoplasm|nucleus	histone binding|protein transporter activity			ovary(2)	2																		---	---	---	---
TIMM17A	10440	broad.mit.edu	37	1	201938497	201938497	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:201938497delT	uc001gxc.2	+							NM_006335	NP_006326			translocase of inner mitochondrial membrane 17						protein targeting to mitochondrion	integral to membrane|mitochondrial inner membrane presequence translocase complex	P-P-bond-hydrolysis-driven protein transmembrane transporter activity				0																		---	---	---	---
KDM5B	10765	broad.mit.edu	37	1	202710853	202710853	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:202710853delA	uc001gyf.2	-						KDM5B_uc009xag.2_Intron|KDM5B_uc001gyg.1_Intron	NM_006618	NP_006609			jumonji, AT rich interactive domain 1B						negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(2)|urinary_tract(1)	5																		---	---	---	---
CD55	1604	broad.mit.edu	37	1	207495788	207495788	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:207495788delT	uc001hfq.3	+	2	456	c.162delT	c.(160-162)AGTfs	p.S54fs	CD55_uc001hfp.3_Frame_Shift_Del_p.S54fs|CD55_uc001hfr.3_Frame_Shift_Del_p.S54fs|CD55_uc010psf.1_RNA|CD55_uc009xcf.2_Frame_Shift_Del_p.S54fs|CD55_uc009xce.2_Frame_Shift_Del_p.S54fs	NM_000574	NP_000565	P08174	DAF_HUMAN	decay accelerating factor for complement isoform	54	Sushi 1.				complement activation, classical pathway|elevation of cytosolic calcium ion concentration|innate immune response|respiratory burst	anchored to membrane|extracellular region|integral to plasma membrane|membrane raft|soluble fraction	receptor activity			ovary(1)	1					Chloramphenicol(DB00446)													---	---	---	---
Unknown	0	broad.mit.edu	37	1	208050386	208050386	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:208050386delT								LOC148696 (54446 upstream) : CD34 (9497 downstream)																																			---	---	---	---
PLXNA2	5362	broad.mit.edu	37	1	208391087	208391087	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:208391087delC	uc001hgz.2	-	2	939	c.181delG	c.(181-183)GCCfs	p.A61fs	PLXNA2_uc001hha.3_Frame_Shift_Del_p.A115fs	NM_025179	NP_079455	O75051	PLXA2_HUMAN	plexin A2 precursor	61	Extracellular (Potential).|Sema.				axon guidance	integral to membrane|intracellular|plasma membrane				ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.199)														---	---	---	---
LAMB3	3914	broad.mit.edu	37	1	209803202	209803202	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:209803202delC	uc001hhg.2	-	9	1402	c.1012delG	c.(1012-1014)GCAfs	p.A338fs	LAMB3_uc009xco.2_Frame_Shift_Del_p.A338fs|LAMB3_uc001hhh.2_Frame_Shift_Del_p.A338fs|LAMB3_uc010psl.1_RNA	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	338	Laminin EGF-like 2.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)														---	---	---	---
RPS6KC1	26750	broad.mit.edu	37	1	213290507	213290508	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:213290507_213290508delTT	uc010ptr.1	+						RPS6KC1_uc001hkd.2_Intron|RPS6KC1_uc010pts.1_Intron|RPS6KC1_uc010ptt.1_Intron|RPS6KC1_uc010ptu.1_Intron|RPS6KC1_uc010ptv.1_Intron|RPS6KC1_uc001hke.2_Intron	NM_012424	NP_036556			ribosomal protein S6 kinase, 52kDa, polypeptide						cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)														---	---	---	---
KCNK2	3776	broad.mit.edu	37	1	215256538	215256538	+	5'Flank	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:215256538delC	uc001hkq.2	+						KCNK2_uc001hko.2_Intron|KCNK2_uc009xdm.2_Intron|KCNK2_uc001hkp.2_Intron|KCNK2_uc010pua.1_5'Flank|KCNK2_uc001hkr.3_5'Flank	NM_001017425	NP_001017425			potassium channel, subfamily K, member 2 isoform								outward rectifier potassium channel activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)													---	---	---	---
USH2A	7399	broad.mit.edu	37	1	215814143	215814143	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:215814143delA	uc001hku.1	-							NM_206933	NP_996816			usherin isoform B						maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)											HNSCC(13;0.011)			---	---	---	---
USH2A	7399	broad.mit.edu	37	1	216073975	216073975	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:216073975delT	uc001hku.1	-							NM_206933	NP_996816			usherin isoform B						maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)											HNSCC(13;0.011)			---	---	---	---
GPATCH2	55105	broad.mit.edu	37	1	217793264	217793264	+	Frame_Shift_Del	DEL	T	-	-	rs71763020		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:217793264delT	uc001hlf.1	-	2	730	c.634delA	c.(634-636)AGAfs	p.R212fs	GPATCH2_uc001hlg.3_Frame_Shift_Del_p.R212fs	NM_018040	NP_060510	Q9NW75	GPTC2_HUMAN	G patch domain containing 2	212						intracellular	nucleic acid binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0397)|all cancers(67;0.0744)|GBM - Glioblastoma multiforme(131;0.0872)														---	---	---	---
EPRS	2058	broad.mit.edu	37	1	220213474	220213474	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:220213474delA	uc001hly.1	-						EPRS_uc010puf.1_Intron|EPRS_uc001hlz.1_Intron|EPRS_uc009xdt.1_Intron	NM_004446	NP_004437			glutamyl-prolyl tRNA synthetase						glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)													---	---	---	---
AIDA	64853	broad.mit.edu	37	1	222876706	222876706	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:222876706delA	uc001hnn.2	-						AIDA_uc001hno.2_Intron|AIDA_uc010pus.1_Intron	NM_022831	NP_073742			axin interactor, dorsalization associated						dorsal/ventral pattern formation|negative regulation of JNK cascade|negative regulation of JUN kinase activity|regulation of protein homodimerization activity						0																		---	---	---	---
TP53BP2	7159	broad.mit.edu	37	1	223989746	223989746	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:223989746delT	uc010pvb.1	-						TP53BP2_uc001hod.2_Intron|TP53BP2_uc010puz.1_5'Flank|TP53BP2_uc010pva.1_Intron	NM_001031685	NP_001026855			tumor protein p53 binding protein, 2 isoform 1						apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(2)|lung(1)	3				GBM - Glioblastoma multiforme(131;0.0958)														---	---	---	---
CNIH3	149111	broad.mit.edu	37	1	224848979	224848979	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:224848979delT	uc001hos.1	+							NM_152495	NP_689708			cornichon homolog 3						intracellular signal transduction|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic shaft|postsynaptic membrane					0	Breast(184;0.218)			GBM - Glioblastoma multiforme(131;0.073)														---	---	---	---
LBR	3930	broad.mit.edu	37	1	225600030	225600030	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:225600030delT	uc001hoy.2	-						LBR_uc001hoz.2_Intron|LBR_uc001hpa.1_Intron	NM_002296	NP_002287			lamin B receptor						cholesterol biosynthetic process	integral to nuclear inner membrane	chromo shadow domain binding|delta14-sterol reductase activity|DNA binding|lamin binding|receptor activity			ovary(1)|skin(1)	2	Breast(184;0.165)			GBM - Glioblastoma multiforme(131;0.117)														---	---	---	---
LIN9	286826	broad.mit.edu	37	1	226438518	226438518	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:226438518delA	uc001hqa.2	-						LIN9_uc001hqb.2_Intron|LIN9_uc001hqc.2_Intron|LIN9_uc009xel.1_Intron	NM_173083	NP_775106			lin-9 homolog						cell cycle|DNA replication	nucleoplasm					0	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.131)														---	---	---	---
ITPKB	3707	broad.mit.edu	37	1	226830027	226830027	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:226830027delT	uc010pvo.1	-							NM_002221	NP_002212			1D-myo-inositol-trisphosphate 3-kinase B								ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			ovary(4)|central_nervous_system(1)	5		Prostate(94;0.0773)																---	---	---	---
AGT	183	broad.mit.edu	37	1	230842067	230842067	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:230842067delC	uc001hty.3	-						AGT_uc009xfe.2_Intron|AGT_uc009xff.2_Intron	NM_000029	NP_000020			angiotensinogen preproprotein						activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|blood vessel remodeling|cell-cell signaling|cellular lipid metabolic process|G-protein signaling, coupled to cGMP nucleotide second messenger|kidney development|low-density lipoprotein particle remodeling|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of activation of JAK2 kinase activity|positive regulation of apoptosis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of cardiac muscle hypertrophy|positive regulation of cholesterol esterification|positive regulation of cytokine production|positive regulation of endothelial cell migration|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription, DNA-dependent|regulation of proteolysis|regulation of renal output by angiotensin|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|response to muscle activity involved in regulation of muscle adaptation	extracellular space|soluble fraction	acetyltransferase activator activity|growth factor activity|hormone activity|serine-type endopeptidase inhibitor activity|type 1 angiotensin receptor binding|type 2 angiotensin receptor binding				0	Breast(184;0.0735)|Ovarian(103;0.183)	all_cancers(173;4.64e-23)|all_epithelial(177;3.61e-18)|Breast(1374;0.00093)|all_neural(198;0.0604)|Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;4.4e-06)|Colorectal(1306;5.46e-06)|COAD - Colon adenocarcinoma(196;0.000256)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)	Aliskiren(DB01258)|Atorvastatin(DB01076)|Cilazapril(DB01340)|Irbesartan(DB01029)|Lisinopril(DB00722)|Ouabain(DB01092)|Simvastatin(DB00641)													---	---	---	---
TRIM67	440730	broad.mit.edu	37	1	231342636	231342636	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:231342636delG	uc009xfn.1	+							NM_001004342	NP_001004342			tripartite motif-containing 67							cytoplasm|cytoskeleton	zinc ion binding			ovary(2)|breast(1)|kidney(1)	4	Breast(184;0.0871)	all_cancers(173;0.189)|Prostate(94;0.167)																---	---	---	---
TSNAX-DISC1	100303453	broad.mit.edu	37	1	231678529	231678529	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:231678529delT	uc010pwg.1	+						TSNAX-DISC1_uc010pwe.1_Intron|TSNAX-DISC1_uc010pwf.1_Intron|TSNAX-DISC1_uc010pwh.1_Intron|TSNAX-DISC1_uc010pwi.1_Intron|TSNAX-DISC1_uc010pwj.1_Intron|TSNAX-DISC1_uc010pwk.1_Intron|TSNAX-DISC1_uc010pwl.1_Intron|TSNAX_uc001huw.2_Intron	NM_001012959	NP_001012977			disrupted in schizophrenia 1 isoform S												0																		---	---	---	---
PCNXL2	80003	broad.mit.edu	37	1	233135968	233135968	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:233135968delC	uc001hvl.2	-						PCNXL2_uc001hvk.1_Intron|PCNXL2_uc001hvm.1_Intron	NM_014801	NP_055616			pecanex-like 2							integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)																---	---	---	---
TARBP1	6894	broad.mit.edu	37	1	234528460	234528460	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:234528460delT	uc001hwd.2	-							NM_005646	NP_005637			TAR RNA binding protein 1						regulation of transcription from RNA polymerase II promoter|RNA processing	nucleus	RNA binding|RNA methyltransferase activity			ovary(2)|skin(1)	3	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)															---	---	---	---
LYST	1130	broad.mit.edu	37	1	235945141	235945141	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:235945141delA	uc001hxj.2	-						LYST_uc009xgb.1_Intron|LYST_uc010pxs.1_Intron	NM_000081	NP_000072			lysosomal trafficking regulator						defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)											Chediak-Higashi_syndrome				---	---	---	---
LYST	1130	broad.mit.edu	37	1	235945481	235945483	+	Intron	DEL	TTT	-	-	rs11300413		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:235945481_235945483delTTT	uc001hxj.2	-						LYST_uc009xgb.1_Intron|LYST_uc010pxs.1_Intron	NM_000081	NP_000072			lysosomal trafficking regulator						defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)											Chediak-Higashi_syndrome				---	---	---	---
LYST	1130	broad.mit.edu	37	1	235993390	235993391	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:235993390_235993391delTT	uc001hxj.2	-						LYST_uc009xgb.1_Intron|LYST_uc010pxs.1_Intron|LYST_uc001hxl.1_Intron|LYST_uc001hxm.2_Intron|LYST_uc001hxn.1_3'UTR	NM_000081	NP_000072			lysosomal trafficking regulator						defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)											Chediak-Higashi_syndrome				---	---	---	---
NID1	4811	broad.mit.edu	37	1	236180604	236180604	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:236180604delT	uc001hxo.2	-						NID1_uc009xgd.2_Intron	NM_002508	NP_002499			nidogen 1 precursor						cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)													---	---	---	---
ERO1LB	56605	broad.mit.edu	37	1	236393400	236393400	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:236393400delT	uc001hxt.2	-							NM_019891	NP_063944			endoplasmic reticulum oxidoreductin 1-Lbeta						electron transport chain|protein thiol-disulfide exchange|transport	endoplasmic reticulum membrane	flavin adenine dinucleotide binding|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor|unfolded protein binding				0	Ovarian(103;0.0634)|Breast(184;0.247)	all_cancers(173;0.123)|Acute lymphoblastic leukemia(190;0.205)|Prostate(94;0.219)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)															---	---	---	---
RYR2	6262	broad.mit.edu	37	1	237819091	237819091	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:237819091delT	uc001hyl.1	+							NM_001035	NP_001026			cardiac muscle ryanodine receptor						cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)															---	---	---	---
EXO1	9156	broad.mit.edu	37	1	242016438	242016439	+	Intron	DEL	TG	-	-	rs35698447		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:242016438_242016439delTG	uc001hzh.2	+						EXO1_uc001hzi.2_Intron|EXO1_uc001hzj.2_Intron|EXO1_uc009xgq.2_Intron	NM_130398	NP_569082			exonuclease 1 isoform b						meiosis|mismatch repair	nucleus	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|flap endonuclease activity|metal ion binding|protein binding|protein binding|ribonuclease H activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity			ovary(2)|lung(2)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;0.0555)	OV - Ovarian serous cystadenocarcinoma(106;0.0107)										Direct_reversal_of_damage|Editing_and_processing_nucleases					---	---	---	---
EXO1	9156	broad.mit.edu	37	1	242016558	242016559	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:242016558_242016559delTT	uc001hzh.2	+						EXO1_uc001hzi.2_Intron|EXO1_uc001hzj.2_Intron|EXO1_uc009xgq.2_Intron	NM_130398	NP_569082			exonuclease 1 isoform b						meiosis|mismatch repair	nucleus	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|flap endonuclease activity|metal ion binding|protein binding|protein binding|ribonuclease H activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity			ovary(2)|lung(2)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;0.0555)	OV - Ovarian serous cystadenocarcinoma(106;0.0107)										Direct_reversal_of_damage|Editing_and_processing_nucleases					---	---	---	---
PLD5	200150	broad.mit.edu	37	1	242253557	242253557	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:242253557delA	uc001hzn.1	-						PLD5_uc001hzl.3_Intron|PLD5_uc001hzm.3_Intron|PLD5_uc001hzo.1_Intron					RecName: Full=Inactive phospholipase D5;          Short=Inactive PLD 5; AltName: Full=Inactive choline phosphatase 5; AltName: Full=Inactive phosphatidylcholine-hydrolyzing phospholipase D5; AltName: Full=PLDc;							integral to membrane	catalytic activity			ovary(6)	6	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)															---	---	---	---
CEP170	9859	broad.mit.edu	37	1	243327520	243327520	+	Intron	DEL	A	-	-	rs1815604	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:243327520delA	uc001hzs.2	-						CEP170_uc001hzt.2_Intron|CEP170_uc001hzu.2_Intron|CEP170_uc001hzv.1_Intron	NM_014812	NP_055627			centrosomal protein 170kDa isoform alpha							centriole|microtubule|spindle				ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)															---	---	---	---
KIF26B	55083	broad.mit.edu	37	1	245775408	245775417	+	Intron	DEL	GAGAGAGAGA	-	-	rs58523688		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:245775408_245775417delGAGAGAGAGA	uc001ibf.1	+						KIF26B_uc010pyq.1_Intron|KIF26B_uc001ibg.1_Intron	NM_018012	NP_060482			kinesin family member 26B						microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)															---	---	---	---
KIF26B	55083	broad.mit.edu	37	1	245847715	245847716	+	Intron	INS	-	G	G	rs149909437	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:245847715_245847716insG	uc001ibf.1	+						KIF26B_uc001ibg.1_Intron|KIF26B_uc001ibh.1_Intron	NM_018012	NP_060482			kinesin family member 26B						microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)															---	---	---	---
KIF26B	55083	broad.mit.edu	37	1	245861343	245861344	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:245861343_245861344insA	uc001ibf.1	+							NM_018012	NP_060482			kinesin family member 26B						microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)															---	---	---	---
AHCTF1	25909	broad.mit.edu	37	1	247068800	247068800	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:247068800delA	uc001ibu.1	-						AHCTF1_uc001ibv.1_Intron	NM_015446	NP_056261			transcription factor ELYS						cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			ovary(5)|skin(2)	7	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)															---	---	---	---
AHCTF1	25909	broad.mit.edu	37	1	247076400	247076402	+	Intron	DEL	TTT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:247076400_247076402delTTT	uc001ibu.1	-						AHCTF1_uc001ibv.1_Intron	NM_015446	NP_056261			transcription factor ELYS						cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			ovary(5)|skin(2)	7	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)															---	---	---	---
ZNF124	7678	broad.mit.edu	37	1	247319909	247319909	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:247319909delT	uc001ick.2	-	4	1154	c.1015delA	c.(1015-1017)ACTfs	p.T339fs	ZNF124_uc001ici.2_Intron|ZNF124_uc001icj.1_Frame_Shift_Del_p.T277fs	NM_003431	NP_003422	Q15973	ZN124_HUMAN	zinc finger protein 124	339	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1	all_cancers(71;5.07e-05)|all_epithelial(71;8.72e-06)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0488)|Lung NSC(105;0.053)		OV - Ovarian serous cystadenocarcinoma(106;0.00739)															---	---	---	---
Unknown	0	broad.mit.edu	37	1	247372680	247372681	+	IGR	DEL	AC	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:247372680_247372681delAC								ZNF124 (37362 upstream) : VN1R5 (46693 downstream)																																			---	---	---	---
TRIM58	25893	broad.mit.edu	37	1	248030993	248030993	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:248030993delA	uc001ido.2	+						OR2W3_uc001idp.1_5'Flank	NM_015431	NP_056246			tripartite motif-containing 58							intracellular	zinc ion binding			skin(3)|ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)	7	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)															---	---	---	---
Unknown	0	broad.mit.edu	37	1	248844550	248844550	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:248844550delT								OR2T27 (30365 upstream) : OR14I1 (120 downstream)																																			---	---	---	---
PGBD2	267002	broad.mit.edu	37	1	249207982	249207982	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:249207982delT	uc001ifh.2	+						PGBD2_uc001ifg.2_Intron|PGBD2_uc009xhd.2_Intron	NM_170725	NP_733843			hypothetical protein LOC267002 isoform a											ovary(1)	1	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.012)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)															---	---	---	---
Unknown	0	broad.mit.edu	37	2	2560295	2560296	+	IGR	INS	-	GTGC	GTGC			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:2560295_2560296insGTGC								MYT1L (225250 upstream) : TSSC1 (632445 downstream)																																			---	---	---	---
TAF1B	9014	broad.mit.edu	37	2	9989571	9989571	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:9989571delA	uc002qzz.2	+	3	287	c.187delA	c.(187-189)AAAfs	p.K63fs	TAF1B_uc010exc.2_Frame_Shift_Del_p.K63fs|TAF1B_uc002qzy.3_Frame_Shift_Del_p.K63fs|TAF1B_uc010yja.1_5'UTR|TAF1B_uc010exd.2_5'UTR	NM_005680	NP_005671	Q53T94	TAF1B_HUMAN	TBP-associated factor 1B	63					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|breast(1)|pancreas(1)	3	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
GRHL1	29841	broad.mit.edu	37	2	10095021	10095021	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:10095021delT	uc002raa.2	+						GRHL1_uc002rab.2_Intron|GRHL1_uc002rad.2_Intron|GRHL1_uc010yjb.1_Intron|uc002rac.2_RNA	NM_198182	NP_937825			grainyhead-like 1						cellular lipid metabolic process|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding			pancreas(1)|skin(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.246)														---	---	---	---
GRHL1	29841	broad.mit.edu	37	2	10101687	10101687	+	Intron	DEL	T	-	-	rs138724700		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:10101687delT	uc002raa.2	+						GRHL1_uc002rab.2_Intron|GRHL1_uc002rad.2_Intron|GRHL1_uc010yjb.1_Intron	NM_198182	NP_937825			grainyhead-like 1						cellular lipid metabolic process|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding			pancreas(1)|skin(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.246)														---	---	---	---
C2orf48	348738	broad.mit.edu	37	2	10295168	10295168	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:10295168delA	uc002rai.1	+							NM_182626	NP_872432			hypothetical protein LOC348738												0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.188)														---	---	---	---
NOL10	79954	broad.mit.edu	37	2	10795333	10795333	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:10795333delA	uc002raq.2	-						NOL10_uc010yje.1_Intron|NOL10_uc010yjf.1_Intron|NOL10_uc002rap.2_Intron|NOL10_uc002rar.2_Intron	NM_024894	NP_079170			nucleolar protein 10							nucleolus					0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.207)														---	---	---	---
ROCK2	9475	broad.mit.edu	37	2	11351719	11351719	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:11351719delA	uc002rbd.1	-							NM_004850	NP_004841			Rho-associated, coiled-coil containing protein						axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			stomach(2)|skin(2)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)														---	---	---	---
WDR35	57539	broad.mit.edu	37	2	20130442	20130443	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:20130442_20130443delTT	uc002rdi.2	-						WDR35_uc002rdj.2_Intron|WDR35_uc010ext.2_Intron|WDR35_uc002rdh.2_Intron	NM_001006657	NP_001006658			WD repeat domain 35 isoform 1											ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
LAPTM4A	9741	broad.mit.edu	37	2	20232786	20232786	+	3'UTR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:20232786delA	uc002rdm.2	-	7					LAPTM4A_uc002rdn.2_3'UTR	NM_014713	NP_055528			lysosomal protein transmembrane 4 alpha						transport	endomembrane system|Golgi apparatus|integral to membrane				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
PUM2	23369	broad.mit.edu	37	2	20451242	20451242	+	3'UTR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:20451242delA	uc002rds.1	-	20					PUM2_uc002rdq.1_3'UTR|PUM2_uc002rdt.1_3'UTR|PUM2_uc002rdr.2_3'UTR|PUM2_uc010yjy.1_3'UTR|PUM2_uc002rdu.1_3'UTR|PUM2_uc010yjz.1_3'UTR	NM_015317	NP_056132			pumilio homolog 2						regulation of translation	perinuclear region of cytoplasm|stress granule	protein binding|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
ATAD2B	54454	broad.mit.edu	37	2	23977774	23977774	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:23977774delT	uc002rek.3	-						ATAD2B_uc010yki.1_Intron|ATAD2B_uc002rei.3_Intron|ATAD2B_uc002rej.3_Intron	NM_017552	NP_060022			ATPase family, AAA domain containing 2B								ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
LOC375190	375190	broad.mit.edu	37	2	24344299	24344299	+	5'Flank	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:24344299delA	uc010ykl.1	+						LOC375190_uc002rew.2_Intron|LOC375190_uc002rfb.2_5'Flank|PFN4_uc002rfa.1_Intron	NM_001145710	NP_001139182			hypothetical protein LOC375190												0																		---	---	---	---
ITSN2	50618	broad.mit.edu	37	2	24516470	24516470	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:24516470delT	uc002rfe.2	-						ITSN2_uc002rff.2_Intron|ITSN2_uc002rfg.2_Intron|ITSN2_uc010eyd.2_Intron	NM_006277	NP_006268			intersectin 2 isoform 1						endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
ASXL2	55252	broad.mit.edu	37	2	25982519	25982519	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:25982519delA	uc002rgs.2	-						ASXL2_uc002rgt.1_Intron	NM_018263	NP_060733			additional sex combs like 2						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
RAB10	10890	broad.mit.edu	37	2	26321513	26321513	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:26321513delT	uc002rgv.2	+							NM_016131	NP_057215			ras-related GTP-binding protein RAB10						protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
Unknown	0	broad.mit.edu	37	2	26363043	26363043	+	IGR	DEL	A	-	-	rs112696641		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:26363043delA								RAB10 (2721 upstream) : HADHA (50462 downstream)																																			---	---	---	---
HADHB	3032	broad.mit.edu	37	2	26502839	26502839	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:26502839delA	uc002rgz.2	+						HADHB_uc010ykv.1_Intron|HADHB_uc010ykw.1_Intron|HADHB_uc002rha.2_Intron|HADHB_uc010ykx.1_Intron	NM_000183	NP_000174			mitochondrial trifunctional protein, beta						fatty acid beta-oxidation	mitochondrial nucleoid	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acyltransferase activity|enoyl-CoA hydratase activity|protein binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
EPT1	85465	broad.mit.edu	37	2	26598200	26598200	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:26598200delT	uc010ykz.1	+						EPT1_uc010eyl.1_Intron	NM_033505	NP_277040			selenoprotein I						phospholipid biosynthetic process	integral to membrane	ethanolaminephosphotransferase activity|metal ion binding				0																		---	---	---	---
CAD	790	broad.mit.edu	37	2	27464358	27464358	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27464358delC	uc002rji.2	+						CAD_uc010eyw.2_Intron	NM_004341	NP_004332			carbamoylphosphate synthetase 2/aspartate						'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			ovary(4)|large_intestine(2)|kidney(2)|lung(1)|pancreas(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)													---	---	---	---
PPM1G	5496	broad.mit.edu	37	2	27605697	27605698	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27605697_27605698delTT	uc002rkl.2	-						ZNF513_uc002rkj.2_5'Flank|ZNF513_uc002rkk.2_5'Flank|PPM1G_uc002rkm.2_Intron	NM_002707	NP_002698			protein phosphatase 1G						cell cycle arrest|protein dephosphorylation	cytoplasm|nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
IFT172	26160	broad.mit.edu	37	2	27678781	27678781	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27678781delA	uc002rku.2	-						IFT172_uc010ezb.2_5'Flank	NM_015662	NP_056477			selective LIM binding factor homolog						cilium assembly	cilium	binding			large_intestine(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
ZNF512	84450	broad.mit.edu	37	2	27825265	27825265	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27825265delT	uc002rla.2	+						ZNF512_uc010ylv.1_Intron|ZNF512_uc010ylw.1_Intron|ZNF512_uc002rlb.2_Intron|ZNF512_uc010ylx.1_Intron|ZNF512_uc002rlc.2_Intron|ZNF512_uc010yly.1_Intron|ZNF512_uc010ylz.1_Intron	NM_032434	NP_115810			zinc finger protein 512						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
WDR43	23160	broad.mit.edu	37	2	29135433	29135433	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:29135433delT	uc002rmo.2	+						SNORD92_uc002rmp.1_5'Flank	NM_015131	NP_055946			WD repeat domain 43							nucleolus				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
GALNT14	79623	broad.mit.edu	37	2	31360999	31360999	+	5'UTR	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:31360999delC	uc002rnr.2	-	1					GALNT14_uc002rns.2_5'UTR|GALNT14_uc010ymr.1_5'UTR|GALNT14_uc010ezo.1_5'UTR|GALNT14_uc010ezp.1_Intron	NM_024572	NP_078848			N-acetylgalactosaminyltransferase 14							Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(2)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
XDH	7498	broad.mit.edu	37	2	31587238	31587238	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:31587238delA	uc002rnv.1	-							NM_000379	NP_000370			xanthine dehydrogenase						purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)													---	---	---	---
SPAST	6683	broad.mit.edu	37	2	32314465	32314465	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:32314465delT	uc002roc.2	+						SPAST_uc002rod.2_Intron	NM_014946	NP_055761			spastin isoform 1						cell cycle|cell death|cell differentiation|cytokinesis, completion of separation|ER to Golgi vesicle-mediated transport|microtubule bundle formation|microtubule severing|nervous system development|protein hexamerization|protein homooligomerization	endoplasmic reticulum|endosome|integral to membrane|microtubule|microtubule organizing center|nucleus|perinuclear region of cytoplasm|spindle	alpha-tubulin binding|ATP binding|beta-tubulin binding|microtubule binding|microtubule-severing ATPase activity			breast(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)																	---	---	---	---
YIPF4	84272	broad.mit.edu	37	2	32517177	32517177	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:32517177delT	uc002rok.2	+							NM_032312	NP_115688			Yip1 domain family, member 4							endoplasmic reticulum|integral to membrane	protein binding				0	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
TTC27	55622	broad.mit.edu	37	2	32892001	32892001	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:32892001delT	uc002rom.2	+						TTC27_uc010ymx.1_Intron	NM_017735	NP_060205			tetratricopeptide repeat domain 27								protein binding			central_nervous_system(1)	1																		---	---	---	---
LTBP1	4052	broad.mit.edu	37	2	33359778	33359778	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:33359778delT	uc002ros.2	+						LTBP1_uc002rot.2_5'UTR|LTBP1_uc002rou.2_5'UTR|LTBP1_uc002rov.2_5'UTR|LTBP1_uc010ymz.1_5'UTR|LTBP1_uc010yna.1_5'UTR	NM_206943	NP_996826			latent transforming growth factor beta binding						negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)																---	---	---	---
RASGRP3	25780	broad.mit.edu	37	2	33740066	33740066	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:33740066delT	uc002rox.2	+						RASGRP3_uc010ync.1_Intron|RASGRP3_uc002roy.2_Intron	NM_170672	NP_733772			RAS guanyl releasing protein 3 (calcium and						MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			lung(3)|ovary(1)|pancreas(1)	5	all_hematologic(175;0.115)																	---	---	---	---
RASGRP3	25780	broad.mit.edu	37	2	33745932	33745932	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:33745932delT	uc002rox.2	+						RASGRP3_uc010ync.1_Intron|RASGRP3_uc002roy.2_Intron	NM_170672	NP_733772			RAS guanyl releasing protein 3 (calcium and						MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			lung(3)|ovary(1)|pancreas(1)	5	all_hematologic(175;0.115)																	---	---	---	---
STRN	6801	broad.mit.edu	37	2	37088407	37088407	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:37088407delA	uc002rpn.2	-						STRN_uc010ezx.2_Intron	NM_003162	NP_003153			striatin, calmodulin binding protein						dendrite development|locomotory behavior|negative regulation of cell proliferation|tight junction assembly|Wnt receptor signaling pathway	cytoplasm|dendritic spine|neuronal cell body|postsynaptic density|postsynaptic membrane|tight junction	armadillo repeat domain binding|calmodulin binding|estrogen receptor binding|protein complex binding|protein phosphatase 2A binding			skin(1)	1		Ovarian(717;0.0129)|all_hematologic(82;0.21)																---	---	---	---
C2orf56	55471	broad.mit.edu	37	2	37471129	37471129	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:37471129delT	uc002rqa.3	+						C2orf56_uc010ynj.1_Intron|C2orf56_uc002rqc.3_Intron|C2orf56_uc010ynk.1_Intron|C2orf56_uc010ynl.1_Intron|C2orf56_uc010fah.2_Intron	NM_144736	NP_653337			hypothetical protein LOC55471 isoform 1						mitochondrial respiratory chain complex I assembly	mitochondrion	enzyme binding|methyltransferase activity			central_nervous_system(1)	1		all_hematologic(82;0.21)																---	---	---	---
Unknown	0	broad.mit.edu	37	2	38456196	38456197	+	IGR	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:38456196_38456197delAA								C2orf58 (47205 upstream) : ATL2 (65834 downstream)																																			---	---	---	---
SOS1	6654	broad.mit.edu	37	2	39234429	39234429	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:39234429delG	uc002rrk.3	-						SOS1_uc002rrj.3_Intron	NM_005633	NP_005624			son of sevenless homolog 1						apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(4)|breast(3)|lung(2)|central_nervous_system(1)	10		all_hematologic(82;0.21)												Noonan_syndrome				---	---	---	---
Unknown	0	broad.mit.edu	37	2	41384162	41384162	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:41384162delA								SLC8A1 (644587 upstream) : PKDCC (890999 downstream)																																			---	---	---	---
EML4	27436	broad.mit.edu	37	2	42508205	42508205	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:42508205delA	uc002rsi.2	+						EML4_uc010fap.2_Intron	NM_019063	NP_061936			echinoderm microtubule associated protein like 4						microtubule-based process|mitosis	cytoplasm|microtubule	protein binding		EML4/ALK(246)	lung(246)|ovary(2)|central_nervous_system(1)|skin(1)	250								T	ALK	NSCLC								---	---	---	---
MTA3	57504	broad.mit.edu	37	2	42936306	42936306	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:42936306delT	uc002rso.1	+						MTA3_uc002rsp.1_Intron|MTA3_uc002rsq.2_3'UTR|MTA3_uc002rsr.2_3'UTR	NM_020744	NP_065795			metastasis associated 1 family, member 3							nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2																		---	---	---	---
C2orf34	79823	broad.mit.edu	37	2	44942370	44942370	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:44942370delT	uc002rum.2	+							NM_024766	NP_079042			hypothetical protein LOC79823							cytoplasm	calmodulin-lysine N-methyltransferase activity				0		all_hematologic(82;0.0892)|Acute lymphoblastic leukemia(82;0.17)																---	---	---	---
Unknown	0	broad.mit.edu	37	2	47959043	47959044	+	IGR	DEL	AA	-	-	rs12992211		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:47959043_47959044delAA								MSH2 (52535 upstream) : MSH6 (51177 downstream)																																			---	---	---	---
FOXN2	3344	broad.mit.edu	37	2	48600521	48600521	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:48600521delA	uc002rwh.1	+							NM_002158	NP_002149			T-cell leukemia virus enhancer factor						embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.0272)|LUSC - Lung squamous cell carcinoma(58;0.036)															---	---	---	---
KLRAQ1	129285	broad.mit.edu	37	2	48738838	48738841	+	Intron	DEL	AAAA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:48738838_48738841delAAAA	uc002rwm.2	+						KLRAQ1_uc002rwl.2_Intron|KLRAQ1_uc002rwk.2_Intron|KLRAQ1_uc010yok.1_Intron	NM_001135629	NP_001129101			KLRAQ motif containing 1 isoform 1											ovary(1)	1																		---	---	---	---
KLRAQ1	129285	broad.mit.edu	37	2	48741806	48741806	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:48741806delT	uc002rwm.2	+						KLRAQ1_uc002rwl.2_Intron|KLRAQ1_uc002rwk.2_Intron|KLRAQ1_uc010yok.1_Intron	NM_001135629	NP_001129101			KLRAQ motif containing 1 isoform 1											ovary(1)	1																		---	---	---	---
STON1-GTF2A1L	286749	broad.mit.edu	37	2	48807594	48807594	+	5'Flank	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:48807594delT	uc010yol.1	+						STON1_uc002rwo.3_Intron|STON1_uc010fbm.2_Intron|STON1-GTF2A1L_uc002rwp.1_Intron|STON1_uc002rwr.2_5'Flank|STON1_uc002rwq.2_5'Flank	NM_006873	NP_006864			stonin 1						endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)															---	---	---	---
LHCGR	3973	broad.mit.edu	37	2	48952906	48952906	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:48952906delA	uc002rwu.3	-						GTF2A1L_uc002rwt.2_Intron|LHCGR_uc002rwv.2_Intron	NM_000233	NP_000224			luteinizing hormone/choriogonadotropin receptor						male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			ovary(3)|lung(2)|breast(2)|skin(1)	8		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)									Familial_Male-Limited_Precocious_Puberty				---	---	---	---
ASB3	51130	broad.mit.edu	37	2	53897896	53897896	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:53897896delT	uc002rxg.1	-						ASB3_uc002rxh.1_Intron|ASB3_uc002rxi.3_Intron|ASB3_uc002rxf.1_Intron	NM_016115	NP_057199			ankyrin repeat and SOCS box-containing protein 3						intracellular signal transduction					ovary(1)|kidney(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)															---	---	---	---
PSME4	23198	broad.mit.edu	37	2	54114940	54114940	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:54114940delA	uc002rxp.2	-						PSME4_uc010yop.1_Intron|PSME4_uc010yoq.1_Intron|PSME4_uc010fbu.1_Intron|PSME4_uc010fbv.1_Intron|PSME4_uc010fbt.1_5'Flank	NM_014614	NP_055429			proteasome (prosome, macropain) activator						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			ovary(2)|breast(2)|pancreas(1)	5			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)															---	---	---	---
PSME4	23198	broad.mit.edu	37	2	54135789	54135789	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:54135789delA	uc002rxp.2	-						PSME4_uc010yop.1_Intron|PSME4_uc010yoq.1_Intron|PSME4_uc010fbu.1_Intron|PSME4_uc010fbv.1_Intron	NM_014614	NP_055429			proteasome (prosome, macropain) activator						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			ovary(2)|breast(2)|pancreas(1)	5			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)															---	---	---	---
SPTBN1	6711	broad.mit.edu	37	2	54895695	54895695	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:54895695delA	uc002rxu.2	+	36	7333	c.7084delA	c.(7084-7086)AAAfs	p.K2362fs	SPTBN1_uc010you.1_Frame_Shift_Del_p.K352fs	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	2362					actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)															---	---	---	---
CCDC88A	55704	broad.mit.edu	37	2	55523308	55523308	+	Intron	DEL	C	-	-	rs141740382	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:55523308delC	uc002ryv.2	-						CCDC88A_uc010yoz.1_Intron|CCDC88A_uc010ypa.1_Intron|CCDC88A_uc002ryt.2_Intron|CCDC88A_uc010fbw.2_Intron|CCDC88A_uc002ryu.2_Intron|CCDC88A_uc002rys.2_Intron|CCDC88A_uc002ryw.2_Intron|CCDC88A_uc010fby.1_Intron	NM_001135597	NP_001129069			coiled-coil domain containing 88A isoform 1						activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4																		---	---	---	---
CCDC104	112942	broad.mit.edu	37	2	55756167	55756167	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:55756167delT	uc002ryy.2	+						CCDC104_uc002ryx.2_Intron	NM_080667	NP_542398			coiled-coil domain containing 104											ovary(1)	1			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)															---	---	---	---
PNPT1	87178	broad.mit.edu	37	2	55881873	55881873	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:55881873delT	uc002rzf.2	-						PNPT1_uc002rzg.2_Intron	NM_033109	NP_149100			polyribonucleotide nucleotidyltransferase 1						mRNA catabolic process|RNA processing	plasma membrane	3'-5'-exoribonuclease activity|polyribonucleotide nucleotidyltransferase activity|RNA binding				0			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)															---	---	---	---
PNPT1	87178	broad.mit.edu	37	2	55907943	55907943	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:55907943delA	uc002rzf.2	-						PNPT1_uc002rzg.2_Intron	NM_033109	NP_149100			polyribonucleotide nucleotidyltransferase 1						mRNA catabolic process|RNA processing	plasma membrane	3'-5'-exoribonuclease activity|polyribonucleotide nucleotidyltransferase activity|RNA binding				0			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)															---	---	---	---
Unknown	0	broad.mit.edu	37	2	55931430	55931430	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:55931430delT								PNPT1 (10419 upstream) : EFEMP1 (161673 downstream)																																			---	---	---	---
VRK2	7444	broad.mit.edu	37	2	58374443	58374443	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:58374443delT	uc002rzo.2	+						VRK2_uc010fcb.2_Intron|VRK2_uc002rzs.2_Intron|VRK2_uc002rzr.2_Intron|VRK2_uc010fcc.2_Intron|VRK2_uc002rzv.2_Intron|VRK2_uc010fcd.2_Intron|VRK2_uc002rzp.2_Intron|VRK2_uc010ypg.1_Intron|VRK2_uc002rzq.2_Intron|VRK2_uc002rzu.2_Intron|VRK2_uc002rzt.2_Intron	NM_001130482	NP_001123954			vaccinia related kinase 2 isoform 2							integral to membrane	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(1)	1																		---	---	---	---
FANCL	55120	broad.mit.edu	37	2	58449291	58449291	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:58449291delT	uc002rzw.3	-						FANCL_uc002rzx.3_Intron|FANCL_uc010fce.2_Intron|FANCL_uc010fcf.1_Intron	NM_018062	NP_060532			Fanconi anemia, complementation group L isoform						DNA repair	cytoplasm|nucleoplasm	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2													Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				---	---	---	---
REL	5966	broad.mit.edu	37	2	61118739	61118739	+	Intron	DEL	A	-	-	rs10185028	byFrequency;by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:61118739delA	uc002sam.1	+						REL_uc002san.1_Intron	NM_002908	NP_002899			v-rel reticuloendotheliosis viral oncogene						positive regulation of I-kappaB kinase/NF-kappaB cascade	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3	all_hematologic(2;0.0797)	Ovarian(717;0.0728)	LUSC - Lung squamous cell carcinoma(5;6.2e-08)|Lung(5;1.65e-06)|Epithelial(17;0.064)|all cancers(80;0.221)					A		Hodgkin Lymphoma								---	---	---	---
USP34	9736	broad.mit.edu	37	2	61527959	61527962	+	Intron	DEL	AAAA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:61527959_61527962delAAAA	uc002sbe.2	-							NM_014709	NP_055524			ubiquitin specific protease 34						positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)															---	---	---	---
XPO1	7514	broad.mit.edu	37	2	61753670	61753670	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:61753670delA	uc002sbj.2	-						XPO1_uc010fcl.2_Intron|XPO1_uc010ypn.1_Intron|XPO1_uc002sbk.2_Intron	NM_003400	NP_003391			exportin 1						intracellular protein transport|mitotic prometaphase|mRNA metabolic process|mRNA transport|viral genome transport in host cell|viral infectious cycle	annulate lamellae|Cajal body|cytosol|kinetochore|nuclear envelope|nucleolus|ribonucleoprotein complex	protein binding|protein transporter activity|RNA binding			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	4			LUSC - Lung squamous cell carcinoma(7;5.71e-05)|Epithelial(17;0.0662)|all cancers(80;0.226)															---	---	---	---
EHBP1	23301	broad.mit.edu	37	2	63176204	63176205	+	Frame_Shift_Ins	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:63176204_63176205insA	uc002sby.2	+	14	2810_2811	c.2328_2329insA	c.(2326-2331)AAGAAAfs	p.K776fs	EHBP1_uc010fcp.2_Frame_Shift_Ins_p.K741fs|EHBP1_uc002sbz.2_Frame_Shift_Ins_p.K741fs|EHBP1_uc002scb.2_Frame_Shift_Ins_p.K741fs	NM_015252	NP_056067	Q8NDI1	EHBP1_HUMAN	EH domain binding protein 1 isoform 1	776_777						cytoplasm|membrane				ovary(1)|breast(1)	2	Lung NSC(7;0.0951)|all_lung(7;0.169)		LUSC - Lung squamous cell carcinoma(7;7.74e-05)|Epithelial(17;0.189)											Hereditary_Prostate_Cancer				---	---	---	---
VPS54	51542	broad.mit.edu	37	2	64193106	64193106	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:64193106delA	uc002scq.2	-						VPS54_uc002scp.2_Intron|VPS54_uc010fct.2_Intron	NM_016516	NP_057600			vacuolar protein sorting 54 isoform 1						protein transport|retrograde transport, endosome to Golgi						0																		---	---	---	---
MEIS1	4211	broad.mit.edu	37	2	66798467	66798467	+	3'UTR	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:66798467delC	uc002sdu.2	+	13					MEIS1_uc002sdt.2_3'UTR|MEIS1_uc002sdv.2_Frame_Shift_Del_p.P400fs|MEIS1_uc010yqh.1_RNA|MEIS1_uc010yqi.1_3'UTR	NM_002398	NP_002389			Meis homeobox 1								sequence-specific DNA binding transcription factor activity				0																		---	---	---	---
PPP3R1	5534	broad.mit.edu	37	2	68444266	68444266	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:68444266delG	uc002sei.1	-							NM_000945	NP_000936			protein phosphatase 3, regulatory subunit B,						activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals	calcineurin complex|cytosol	calcium ion binding|calcium-dependent protein serine/threonine phosphatase activity|calmodulin binding				0					Pimecrolimus(DB00337)													---	---	---	---
NFU1	27247	broad.mit.edu	37	2	69650601	69650601	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:69650601delA	uc002sfk.2	-						NFU1_uc002sfj.2_Intron|NFU1_uc002sfl.2_Intron|NFU1_uc002sfm.2_Intron|NFU1_uc010fdi.2_Intron|NFU1_uc002sfn.1_Intron	NM_001002755	NP_001002755			HIRA interacting protein 5 isoform 2						iron-sulfur cluster assembly	cytosol|mitochondrion|nucleus	4 iron, 4 sulfur cluster binding|iron ion binding|protein binding				0																		---	---	---	---
GMCL1	64395	broad.mit.edu	37	2	70074579	70074580	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:70074579_70074580insT	uc002sfu.2	+							NM_178439	NP_848526			germ cell-less						cell differentiation|multicellular organismal development|spermatogenesis	nuclear matrix				ovary(3)	3																		---	---	---	---
MIR1285-2	100302268	broad.mit.edu	37	2	70480799	70480799	+	5'Flank	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:70480799delT	hsa-mir-1285-2|MI0006347	-																							0																		---	---	---	---
ADD2	119	broad.mit.edu	37	2	70933540	70933540	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:70933540delT	uc002sgz.2	-	3	466	c.1delA	c.(1-3)ATGfs	p.M1fs	ADD2_uc010fds.1_RNA|ADD2_uc002sgy.2_Frame_Shift_Del_p.M1fs|ADD2_uc002sha.2_Frame_Shift_Del_p.M1fs|ADD2_uc002sgx.2_Frame_Shift_Del_p.M1fs|ADD2_uc010fdt.1_Frame_Shift_Del_p.M1fs|ADD2_uc002shc.1_Frame_Shift_Del_p.M1fs|ADD2_uc002shd.1_Frame_Shift_Del_p.M1fs|ADD2_uc010fdu.1_Frame_Shift_Del_p.M17fs	NM_001617	NP_001608	P35612	ADDB_HUMAN	adducin 2 isoform a	1					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			ovary(2)|pancreas(1)	3																		---	---	---	---
ZNF638	27332	broad.mit.edu	37	2	71653438	71653438	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:71653438delA	uc002shx.2	+						ZNF638_uc002shy.2_Intron|ZNF638_uc002shz.2_Intron|ZNF638_uc002sia.2_Intron|ZNF638_uc002sib.1_Intron|ZNF638_uc010fed.2_Intron|ZNF638_uc002sic.2_Intron|ZNF638_uc002sid.2_Intron	NM_014497	NP_055312			zinc finger protein 638						RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4																		---	---	---	---
EXOC6B	23233	broad.mit.edu	37	2	72740394	72740394	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:72740394delA	uc010fep.2	-						EXOC6B_uc002sij.2_Intron	NM_015189	NP_056004			SEC15-like 2						protein transport|vesicle docking involved in exocytosis	exocyst				central_nervous_system(2)	2																		---	---	---	---
DNAH6	1768	broad.mit.edu	37	2	84777275	84777275	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:84777275delA	uc010fgb.2	+						DNAH6_uc002soo.2_Intron|DNAH6_uc002sop.2_Intron	NM_001370	NP_001361			dynein, axonemal, heavy polypeptide 6						microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			central_nervous_system(1)	1																		---	---	---	---
DNAH6	1768	broad.mit.edu	37	2	84784781	84784793	+	Intron	DEL	AAAAAAAAAAAAA	-	-	rs10660724		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:84784781_84784793delAAAAAAAAAAAAA	uc010fgb.2	+						DNAH6_uc002soo.2_Intron|DNAH6_uc002sop.2_Intron	NM_001370	NP_001361			dynein, axonemal, heavy polypeptide 6						microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			central_nervous_system(1)	1																		---	---	---	---
GGCX	2677	broad.mit.edu	37	2	85787730	85787731	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:85787730_85787731delAA	uc002sps.2	-						GGCX_uc010yss.1_5'Flank|GGCX_uc010yst.1_Intron	NM_000821	NP_000812			gamma-glutamyl carboxylase isoform 1						blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification	endoplasmic reticulum membrane|integral to membrane|membrane fraction	gamma-glutamyl carboxylase activity			ovary(1)	1					Anisindione(DB01125)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Drotrecogin alfa(DB00055)|L-Glutamic Acid(DB00142)|Menadione(DB00170)|Phytonadione(DB01022)													---	---	---	---
POLR1A	25885	broad.mit.edu	37	2	86305127	86305127	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:86305127delA	uc002sqs.2	-							NM_015425	NP_056240			DNA-directed RNA polymerase I A						termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3																		---	---	---	---
REEP1	65055	broad.mit.edu	37	2	86481673	86481674	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:86481673_86481674insA	uc002srh.3	-						REEP1_uc010ytg.1_Intron|REEP1_uc010yth.1_Intron|REEP1_uc010yti.1_Intron	NM_022912	NP_075063			receptor accessory protein 1 isoform 2						cell death|protein insertion into membrane	integral to membrane|mitochondrial membrane	olfactory receptor binding				0																		---	---	---	---
RMND5A	64795	broad.mit.edu	37	2	87359272	87359272	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:87359272delT	uc002srs.3	+											SubName: Full=cDNA FLJ10361 fis, clone NT2RM2001256, highly similar to Anaphase-promoting complex subunit 1;											ovary(1)|skin(1)	2																		---	---	---	---
RGPD1	400966	broad.mit.edu	37	2	88118145	88118145	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:88118145delA	uc010fhc.1	-							NM_001024457	NP_001019628			RANBP2-like and GRIP domain containing 1						intracellular transport		binding				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	2	88292400	88292400	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:88292400delA								RMND5A (253634 upstream) : KRCC1 (34324 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	2	89277834	89277834	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:89277834delT	uc010ytr.1	-						uc002stl.2_Intron					Parts of antibodies, mostly variable regions.																														---	---	---	---
MRPS5	64969	broad.mit.edu	37	2	95771967	95771968	+	Intron	DEL	CA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:95771967_95771968delCA	uc002sub.2	-						MRPS5_uc002suc.2_Intron|MRPS5_uc010yud.1_Intron	NM_031902	NP_114108			mitochondrial ribosomal protein S5						translation	mitochondrion|ribosome	protein binding|RNA binding|structural constituent of ribosome			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
SEMA4C	54910	broad.mit.edu	37	2	97529901	97529901	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:97529901delG	uc002sxh.3	-						SEMA4C_uc002sxf.3_5'Flank|SEMA4C_uc002sxe.2_5'Flank|SEMA4C_uc002sxg.3_Intron	NM_017789	NP_060259			semaphorin 4C precursor						muscle cell differentiation|nervous system development|positive regulation of stress-activated MAPK cascade	cell junction|integral to membrane|postsynaptic density|postsynaptic membrane|synaptic vesicle membrane	receptor activity			skin(2)	2																		---	---	---	---
TMEM131	23505	broad.mit.edu	37	2	98410027	98410027	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:98410027delA	uc002syh.3	-							NM_015348	NP_056163			RW1 protein							integral to membrane				ovary(4)|central_nervous_system(2)	6																		---	---	---	---
TMEM131	23505	broad.mit.edu	37	2	98543876	98543876	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:98543876delA	uc002syh.3	-						TMEM131_uc010yvg.1_Intron|TMEM131_uc002syi.2_Frame_Shift_Del_p.*88fs	NM_015348	NP_056163			RW1 protein							integral to membrane				ovary(4)|central_nervous_system(2)	6																		---	---	---	---
UNC50	25972	broad.mit.edu	37	2	99232795	99232795	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:99232795delT	uc002szc.3	+	4	679	c.527delT	c.(526-528)CTTfs	p.L176fs	C2orf64_uc002sza.2_Intron|UNC50_uc002szb.2_Frame_Shift_Del_p.L176fs|UNC50_uc010yvl.1_Frame_Shift_Del_p.L193fs	NM_014044	NP_054763	Q53HI1	UNC50_HUMAN	unc-50 homolog	176	Helical; (Potential).				protein transport	Golgi membrane|integral to membrane|nuclear inner membrane	RNA binding				0																		---	---	---	---
MGAT4A	11320	broad.mit.edu	37	2	99294749	99294749	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:99294749delA	uc002sze.2	-						MGAT4A_uc010fil.2_Intron	NM_012214	NP_036346			alpha-1,3-mannosyl-glycoprotein						N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			skin(1)	1																		---	---	---	---
LYG2	254773	broad.mit.edu	37	2	99870873	99870893	+	Intron	DEL	AGATAGTATTCTCACAGGCTC	-	-	rs80345491		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:99870873_99870893delAGATAGTATTCTCACAGGCTC	uc002szw.1	-						MRPL30_uc002szl.1_Intron|LYG2_uc010fip.1_5'Flank|LYG2_uc002szx.1_Intron	NM_175735	NP_783862			lysozyme G-like 2 precursor						cell wall macromolecule catabolic process|peptidoglycan catabolic process	extracellular region	lysozyme activity			ovary(1)	1																		---	---	---	---
TXNDC9	10190	broad.mit.edu	37	2	99936110	99936110	+	3'UTR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:99936110delA	uc002szz.2	-	5					MRPL30_uc002szl.1_Intron|TXNDC9_uc010yvp.1_Intron	NM_005783	NP_005774			thioredoxin domain containing 9						cell redox homeostasis		protein binding				0																		---	---	---	---
AFF3	3899	broad.mit.edu	37	2	100181753	100181753	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:100181753delC	uc002tag.2	-						AFF3_uc002taf.2_Intron	NM_002285	NP_002276			AF4/FMR2 family, member 3 isoform 1						multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6																		---	---	---	---
C2orf29	55571	broad.mit.edu	37	2	101883105	101883106	+	Intron	INS	-	CT	CT			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:101883105_101883106insCT	uc002taw.3	+							NM_017546	NP_060016			hypothetical protein LOC55571						cell proliferation|nuclear-transcribed mRNA poly(A) tail shortening	cytosol				ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5																		---	---	---	---
IL1RL2	8808	broad.mit.edu	37	2	102835403	102835403	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:102835403delT	uc002tbs.2	+						IL1RL2_uc002tbt.2_Intron	NM_003854	NP_003845			interleukin 1 receptor-like 2 precursor						cellular defense response|innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity			ovary(2)	2																		---	---	---	---
IL18R1	8809	broad.mit.edu	37	2	102979239	102979239	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:102979239delT	uc002tbw.3	+						IL18R1_uc010ywb.1_Intron|IL18R1_uc010ywc.1_Intron|IL18R1_uc010ywd.1_Intron|IL18R1_uc010fiy.2_Intron	NM_003855	NP_003846			interleukin 18 receptor 1 precursor						innate immune response	integral to membrane|plasma membrane	interleukin-1 receptor activity			ovary(2)|pancreas(1)	3																		---	---	---	---
MRPS9	64965	broad.mit.edu	37	2	105704366	105704366	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:105704366delA	uc002tcn.3	+							NM_182640	NP_872578			mitochondrial ribosomal protein S9 precursor						DNA damage response, detection of DNA damage|translation	mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	2	107315190	107315190	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:107315190delA								RGPD3 (230389 upstream) : ST6GAL2 (102868 downstream)																																			---	---	---	---
LIMS1	3987	broad.mit.edu	37	2	109293051	109293051	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:109293051delT	uc002teg.2	+						LIMS1_uc002tef.2_Intron|LIMS1_uc002teh.2_Intron|LIMS1_uc002tei.2_Intron|LIMS1_uc002tej.2_Intron|LIMS1_uc002tek.3_Intron	NM_004987	NP_004978			LIM and senescent cell antigen-like domains 1						cell aging|cell junction assembly|cellular response to transforming growth factor beta stimulus|negative regulation of transcription, DNA-dependent	cytosol|focal adhesion|perinuclear region of cytoplasm	protein binding|zinc ion binding				0																		---	---	---	---
RANBP2	5903	broad.mit.edu	37	2	109345679	109345679	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:109345679delT	uc002tem.3	+							NM_006267	NP_006258			RAN binding protein 2						carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18																		---	---	---	---
RANBP2	5903	broad.mit.edu	37	2	109371850	109371850	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:109371850delT	uc002tem.3	+							NM_006267	NP_006258			RAN binding protein 2						carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18																		---	---	---	---
SEPT10	151011	broad.mit.edu	37	2	110310463	110310463	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:110310463delA	uc002tew.2	-						SEPT10_uc010ywu.1_Intron|SEPT10_uc002tex.2_Intron|SEPT10_uc002tey.2_Intron|SEPT10_uc010ywv.1_Intron|SEPT10_uc002tev.1_Intron|SEPT10_uc010fjo.2_Intron	NM_144710	NP_653311			septin 10 isoform 1						cell cycle|cell division	septin complex	GTP binding				0																		---	---	---	---
SLC35F5	80255	broad.mit.edu	37	2	114489046	114489046	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:114489046delA	uc002tku.1	-						SLC35F5_uc002tkt.2_Intron	NM_025181	NP_079457			solute carrier family 35, member F5						transport	integral to membrane					0																		---	---	---	---
Unknown	0	broad.mit.edu	37	2	116788271	116788274	+	IGR	DEL	TCCT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:116788271_116788274delTCCT								DPP10 (186335 upstream) : None (None downstream)																																			---	---	---	---
INSIG2	51141	broad.mit.edu	37	2	118860657	118860657	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:118860657delT	uc002tlk.2	+						INSIG2_uc010yye.1_Intron|INSIG2_uc002tll.2_5'Flank	NM_016133	NP_057217			insulin induced protein 2						ER-nuclear sterol response pathway	SREBP-SCAP-Insig complex				ovary(1)|central_nervous_system(1)	2																		---	---	---	---
EPB41L5	57669	broad.mit.edu	37	2	120830821	120830821	+	Intron	DEL	G	-	-	rs73952011	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:120830821delG	uc002tmg.2	+						EPB41L5_uc010flk.2_Intron|EPB41L5_uc010fll.2_Intron|EPB41L5_uc002tmh.3_Intron	NM_020909	NP_065960			erythrocyte membrane protein band 4.1 like 5							cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			ovary(1)	1																		---	---	---	---
CLASP1	23332	broad.mit.edu	37	2	122216728	122216728	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:122216728delT	uc002tnc.2	-						CLASP1_uc002tna.2_5'Flank|CLASP1_uc010yyw.1_Intron|CLASP1_uc002tnb.2_Intron|CLASP1_uc010yyx.1_Intron|CLASP1_uc010yyy.1_Intron|CLASP1_uc010yyz.1_Intron|CLASP1_uc010yza.1_Intron|CLASP1_uc010yzb.1_Intron|CLASP1_uc010yzc.1_Intron|CLASP1_uc002tng.1_Intron	NM_015282	NP_056097			CLIP-associating protein 1 isoform 1						axon guidance|cell division|establishment or maintenance of cell polarity|exit from mitosis|G2/M transition of mitotic cell cycle|microtubule anchoring|microtubule bundle formation|microtubule nucleation|microtubule organizing center organization|mitotic prometaphase|negative regulation of microtubule depolymerization	centrosomal corona|condensed chromosome kinetochore|cortical microtubule cytoskeleton|cytoplasmic microtubule|cytosol|Golgi apparatus|kinetochore microtubule	kinetochore binding|microtubule plus-end binding			ovary(1)|central_nervous_system(1)	2	Renal(3;0.0496)																	---	---	---	---
UGGT1	56886	broad.mit.edu	37	2	128931263	128931263	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:128931263delT	uc002tps.2	+						UGGT1_uc002tpr.2_Intron	NM_020120	NP_064505			UDP-glucose ceramide glucosyltransferase-like 1						'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	2	132768083	132768084	+	IGR	INS	-	G	G	rs111469343	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:132768083_132768084insG								C2orf27B (208849 upstream) : NCRNA00164 (137080 downstream)																																			---	---	---	---
ZRANB3	84083	broad.mit.edu	37	2	136023068	136023068	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:136023068delA	uc002tum.2	-						ZRANB3_uc002tuk.2_Intron|ZRANB3_uc002tul.2_Intron	NM_032143	NP_115519			zinc finger, RAN-binding domain containing 3							intracellular	ATP binding|DNA binding|endonuclease activity|helicase activity|zinc ion binding			lung(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.135)														---	---	---	---
LRP1B	53353	broad.mit.edu	37	2	141115624	141115624	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:141115624delT	uc002tvj.1	-	74	12291	c.11319delA	c.(11317-11319)AAAfs	p.K3773fs		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3773	Extracellular (Potential).|LDL-receptor class A 32.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)											TSP Lung(27;0.18)			---	---	---	---
LRP1B	53353	broad.mit.edu	37	2	141208248	141208249	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:141208248_141208249insA	uc002tvj.1	-							NM_018557	NP_061027			low density lipoprotein-related protein 1B						protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)											TSP Lung(27;0.18)			---	---	---	---
LRP1B	53353	broad.mit.edu	37	2	141474543	141474543	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:141474543delA	uc002tvj.1	-							NM_018557	NP_061027			low density lipoprotein-related protein 1B						protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)											TSP Lung(27;0.18)			---	---	---	---
KYNU	8942	broad.mit.edu	37	2	143798151	143798151	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:143798151delG	uc002tvl.2	+	13	1326	c.1196delG	c.(1195-1197)CGGfs	p.R399fs	KYNU_uc010fnm.2_Frame_Shift_Del_p.R399fs	NM_003937	NP_003928	Q16719	KYNU_HUMAN	kynureninase (L-kynurenine hydrolase) isoform a	399					anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			skin(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)													---	---	---	---
ARHGAP15	55843	broad.mit.edu	37	2	144276716	144276716	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:144276716delA	uc002tvm.3	+						ARHGAP15_uc002tvn.2_Intron	NM_018460	NP_060930			ARHGAP15						regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.151)														---	---	---	---
GTDC1	79712	broad.mit.edu	37	2	144709478	144709478	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:144709478delT	uc002tvp.2	-						GTDC1_uc002tvo.2_Intron|GTDC1_uc002tvq.2_Intron|GTDC1_uc002tvr.2_Intron|GTDC1_uc010fnn.2_Intron|GTDC1_uc002tvs.2_Intron|GTDC1_uc010fno.2_Intron	NM_001006636	NP_001006637			glycosyltransferase-like domain containing 1						biosynthetic process		transferase activity, transferring glycosyl groups			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.0914)														---	---	---	---
Unknown	0	broad.mit.edu	37	2	146656727	146656727	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:146656727delT								None (None upstream) : PABPC1P2 (687898 downstream)																																			---	---	---	---
ACVR2A	92	broad.mit.edu	37	2	148680776	148680776	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:148680776delT	uc002twg.2	+						ACVR2A_uc010zbn.1_Intron|ACVR2A_uc002twh.2_Intron	NM_001616	NP_001607			activin A receptor, type IIA precursor						activin receptor signaling pathway|BMP signaling pathway|positive regulation of activin receptor signaling pathway|positive regulation of bone mineralization|positive regulation of erythrocyte differentiation|positive regulation of osteoblast differentiation|positive regulation of protein phosphorylation	cytoplasm|inhibin-betaglycan-ActRII complex|integral to plasma membrane	ATP binding|coreceptor activity|inhibin beta-A binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|transforming growth factor beta receptor activity			stomach(8)|large_intestine(2)|lung(1)|breast(1)|kidney(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.0969)														---	---	---	---
EPC2	26122	broad.mit.edu	37	2	149529044	149529044	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:149529044delT	uc010zbt.1	+							NM_015630	NP_056445			enhancer of polycomb homolog 2						chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)|breast(1)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.0516)														---	---	---	---
Unknown	0	broad.mit.edu	37	2	149629673	149629673	+	IGR	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:149629673delC								EPC2 (84538 upstream) : KIF5C (3146 downstream)																																			---	---	---	---
KIF5C	3800	broad.mit.edu	37	2	149861973	149861973	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:149861973delA	uc010zbu.1	+	22	2808	c.2440delA	c.(2440-2442)AAAfs	p.K814fs	KIF5C_uc002tws.1_RNA|KIF5C_uc002twu.1_Frame_Shift_Del_p.K96fs	NM_004522	NP_004513	O60282	KIF5C_HUMAN	kinesin family member 5C	814					microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.108)														---	---	---	---
RND3	390	broad.mit.edu	37	2	151343672	151343674	+	Intron	DEL	TTC	-	-	rs71338157		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:151343672_151343674delTTC	uc002txe.2	-						RND3_uc002txf.2_Intron|RND3_uc002txg.2_Intron|RND3_uc010zbv.1_Intron|RND3_uc010zbw.1_5'Flank	NM_005168	NP_005159			ras homolog gene family, member E precursor						actin cytoskeleton organization|cell adhesion|small GTPase mediated signal transduction	Golgi membrane	GTP binding|GTPase activity			lung(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.106)														---	---	---	---
NEB	4703	broad.mit.edu	37	2	152524209	152524209	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:152524209delT	uc010fnx.2	-							NM_004543	NP_004534			nebulin isoform 3						muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)														---	---	---	---
Unknown	0	broad.mit.edu	37	2	156340381	156340381	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:156340381delT								KCNJ3 (627367 upstream) : NR4A2 (840565 downstream)																																			---	---	---	---
PKP4	8502	broad.mit.edu	37	2	159537313	159537313	+	3'UTR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:159537313delT	uc002tzv.2	+	22					PKP4_uc002tzw.2_3'UTR|PKP4_uc002tzx.2_3'UTR|PKP4_uc002uaa.2_3'UTR|uc002uab.1_Intron|PKP4_uc002uac.2_3'UTR|PKP4_uc002uad.2_RNA	NM_003628	NP_003619			plakophilin 4 isoform a						cell adhesion	desmosome	protein binding			ovary(5)|skin(2)	7															HNSCC(62;0.18)			---	---	---	---
RBMS1	5937	broad.mit.edu	37	2	161282846	161282847	+	Intron	INS	-	AGGAAAGG	AGGAAAGG	rs138498508	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:161282846_161282847insAGGAAAGG	uc002ubo.2	-						RBMS1_uc002ubn.2_Intron|RBMS1_uc002ubi.3_Intron|RBMS1_uc002ubm.2_Intron|RBMS1_uc002ubp.2_Intron|RBMS1_uc010fox.2_Intron	NM_016836	NP_058520			RNA binding motif, single stranded interacting						DNA replication|RNA processing	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding|single-stranded DNA binding				0																		---	---	---	---
DPP4	1803	broad.mit.edu	37	2	162903784	162903785	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:162903784_162903785delAA	uc002ubz.2	-						DPP4_uc010fpb.2_Intron|DPP4_uc002uca.1_Intron|DPP4_uc002ucb.1_Intron	NM_001935	NP_001926			dipeptidylpeptidase IV						cell adhesion|endothelial cell migration|negative regulation of extracellular matrix disassembly|positive regulation of cell proliferation|proteolysis|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation|T cell costimulation	apical plasma membrane|cell surface|endocytic vesicle|extracellular region|integral to membrane|invadopodium membrane|lamellipodium membrane|membrane raft	aminopeptidase activity|dipeptidyl-peptidase activity|protease binding|protein homodimerization activity|receptor activity|receptor binding|serine-type endopeptidase activity			ovary(3)	3					Sitagliptin(DB01261)													---	---	---	---
KCNH7	90134	broad.mit.edu	37	2	163361170	163361170	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:163361170delA	uc002uch.1	-						KCNH7_uc002uci.2_Intron	NM_033272	NP_150375			potassium voltage-gated channel, subfamily H,						regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)													---	---	---	---
SCN9A	6335	broad.mit.edu	37	2	167163632	167163632	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:167163632delT	uc010fpl.2	-						SCN9A_uc002udr.1_5'Flank|SCN9A_uc002uds.1_5'Flank|SCN9A_uc002udt.1_5'Flank	NM_002977	NP_002968			sodium channel, voltage-gated, type IX, alpha							voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)													---	---	---	---
STK39	27347	broad.mit.edu	37	2	169038733	169038733	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:169038733delT	uc002uea.2	-							NM_013233	NP_037365			serine threonine kinase 39 (STE20/SPS1 homolog,						response to stress	cytoplasm|nucleus	ATP binding|protein binding|receptor signaling protein serine/threonine kinase activity			central_nervous_system(1)|skin(1)	2																		---	---	---	---
ABCB11	8647	broad.mit.edu	37	2	169828302	169828302	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:169828302delT	uc002ueo.1	-						ABCB11_uc010zda.1_Intron|ABCB11_uc010zdb.1_Intron	NM_003742	NP_003733			ATP-binding cassette, sub-family B (MDR/TAP),						bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			ovary(2)|large_intestine(2)|breast(1)	5					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)													---	---	---	---
KBTBD10	10324	broad.mit.edu	37	2	170350393	170350393	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:170350393delT	uc010zdh.1	+						BBS5_uc002uet.2_Intron|BBS5_uc010fpw.2_Intron	NM_152384	NP_689597			Bardet-Biedl syndrome 5						striated muscle contraction	centrosome|nucleolus|plasma membrane|pseudopodium|ruffle					0																		---	---	---	---
UBR3	130507	broad.mit.edu	37	2	170938525	170938525	+	3'UTR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:170938525delT	uc010zdi.1	+	39					UBR3_uc002ufr.3_RNA|UBR3_uc010fqa.2_3'UTR|UBR3_uc002uft.3_3'UTR|UBR3_uc010zdj.1_3'UTR|UBR3_uc002ufu.3_3'UTR	NM_172070	NP_742067			E3 ubiquitin-protein ligase UBR3						sensory perception of smell|suckling behavior|ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding				0																		---	---	---	---
METTL8	79828	broad.mit.edu	37	2	172195604	172195604	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:172195604delA	uc010zdo.1	-						METTL8_uc002ugu.3_Intron|METTL8_uc002ugv.3_Intron|METTL8_uc002ugt.3_Intron|METTL8_uc002ugs.3_Intron|METTL8_uc010zdp.1_Intron	NM_024770	NP_079046			methyltransferase like 8								methyltransferase activity			ovary(1)	1																		---	---	---	---
HAT1	8520	broad.mit.edu	37	2	172823128	172823128	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:172823128delA	uc002uhi.2	+						HAT1_uc010fqi.2_Intron|HAT1_uc002uhj.2_Intron	NM_003642	NP_003633			histone acetyltransferase 1						chromatin silencing at telomere|DNA packaging	cytoplasm|nuclear matrix|nucleoplasm	histone acetyltransferase activity|protein binding			large_intestine(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.216)															---	---	---	---
HAT1	8520	broad.mit.edu	37	2	172847964	172847964	+	Intron	DEL	A	-	-	rs78900975		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:172847964delA	uc002uhi.2	+						HAT1_uc002uhj.2_Intron	NM_003642	NP_003633			histone acetyltransferase 1						chromatin silencing at telomere|DNA packaging	cytoplasm|nuclear matrix|nucleoplasm	histone acetyltransferase activity|protein binding			large_intestine(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.216)															---	---	---	---
ITGA6	3655	broad.mit.edu	37	2	173338908	173338910	+	In_Frame_Del	DEL	CTC	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:173338908_173338910delCTC	uc002uhp.1	+	6	1104_1106	c.901_903delCTC	c.(901-903)CTCdel	p.L302del	ITGA6_uc010fqk.1_In_Frame_Del_p.L188del|ITGA6_uc010zdy.1_In_Frame_Del_p.L183del|ITGA6_uc002uho.1_In_Frame_Del_p.L302del|ITGA6_uc010fqm.1_5'Flank	NM_001079818	NP_001073286	P23229	ITA6_HUMAN	integrin alpha chain, alpha 6 isoform a	341	FG-GAP 5.|Extracellular (Potential).				blood coagulation|cell adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter	integrin complex	protein binding|receptor activity			ovary(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0979)															---	---	---	---
ITGA6	3655	broad.mit.edu	37	2	173362438	173362438	+	Intron	DEL	T	-	-	rs80263139		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:173362438delT	uc002uhp.1	+						ITGA6_uc010zdy.1_Intron|ITGA6_uc002uho.1_Intron|ITGA6_uc010fqm.1_Intron	NM_001079818	NP_001073286			integrin alpha chain, alpha 6 isoform a						blood coagulation|cell adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter	integrin complex	protein binding|receptor activity			ovary(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0979)															---	---	---	---
ZAK	51776	broad.mit.edu	37	2	173963991	173963991	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:173963991delT	uc002uhz.2	+						ZAK_uc002uhx.2_Intron|ZAK_uc002uhy.2_Intron|ZAK_uc010zei.1_Intron|ZAK_uc002uia.1_Intron	NM_016653	NP_057737			MLK-related kinase isoform 1						activation of JUN kinase activity|activation of MAPKK activity|cell cycle arrest|cell death|cell differentiation|cell proliferation|DNA damage checkpoint|positive regulation of apoptosis|response to radiation	cytoplasm|nucleus	ATP binding|identical protein binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			lung(3)|stomach(1)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.176)															---	---	---	---
SCRN3	79634	broad.mit.edu	37	2	175265664	175265664	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:175265664delA	uc002uiq.2	+						SCRN3_uc010zen.1_Intron|SCRN3_uc010zeo.1_Intron	NM_024583	NP_078859			secernin 3						proteolysis		dipeptidase activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.229)															---	---	---	---
Unknown	0	broad.mit.edu	37	2	177065588	177065588	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:177065588delT								HOXD1 (9953 upstream) : MTX2 (68535 downstream)																																			---	---	---	---
MTX2	10651	broad.mit.edu	37	2	177192969	177192969	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:177192969delT	uc002ukx.2	+						MTX2_uc002ukw.2_Intron	NM_006554	NP_006545			metaxin 2						protein targeting to mitochondrion	mitochondrial outer membrane				ovary(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.00365)|Epithelial(96;0.0654)|all cancers(119;0.181)															---	---	---	---
AGPS	8540	broad.mit.edu	37	2	178301396	178301396	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:178301396delA	uc002ull.2	+						AGPS_uc010zfb.1_Intron	NM_003659	NP_003650			alkyldihydroxyacetone phosphate synthase						ether lipid biosynthetic process	peroxisomal matrix|peroxisomal membrane|plasma membrane	alkylglycerone-phosphate synthase activity|flavin adenine dinucleotide binding|oxidoreductase activity			ovary(2)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0018)|Epithelial(96;0.00919)|all cancers(119;0.0358)															---	---	---	---
AGPS	8540	broad.mit.edu	37	2	178402955	178402955	+	3'UTR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:178402955delT	uc002ull.2	+	20					AGPS_uc010zfb.1_3'UTR	NM_003659	NP_003650			alkyldihydroxyacetone phosphate synthase						ether lipid biosynthetic process	peroxisomal matrix|peroxisomal membrane|plasma membrane	alkylglycerone-phosphate synthase activity|flavin adenine dinucleotide binding|oxidoreductase activity			ovary(2)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0018)|Epithelial(96;0.00919)|all cancers(119;0.0358)															---	---	---	---
RBM45	129831	broad.mit.edu	37	2	178982944	178982944	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:178982944delA	uc002ulv.2	+							NM_152945	NP_694453			RNA binding motif protein 45						cell differentiation|nervous system development	cytoplasm|nucleus	nucleotide binding|RNA binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.00957)|all cancers(119;0.037)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179497149	179497149	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179497149delA	uc010zfg.1	-						TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron	NM_133378	NP_596869			titin isoform N2-A								ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
UBE2E3	10477	broad.mit.edu	37	2	181846888	181846890	+	In_Frame_Del	DEL	CTT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:181846888_181846890delCTT	uc002unq.1	+	3	338_340	c.119_121delCTT	c.(118-123)CCTTCT>CCT	p.S41del	UBE2E3_uc002unr.1_In_Frame_Del_p.S41del|UBE2E3_uc010fri.1_In_Frame_Del_p.S41del	NM_182678	NP_872619	Q969T4	UB2E3_HUMAN	ubiquitin-conjugating enzyme E2E 3	41					protein K11-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|regulation of growth	cytoplasm|nucleolus	ATP binding|protein binding|ubiquitin-protein ligase activity			ovary(1)	1																		---	---	---	---
ITGA4	3676	broad.mit.edu	37	2	182344708	182344708	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:182344708delT	uc002unu.2	+						ITGA4_uc010zfl.1_Intron	NM_000885	NP_000876			integrin alpha 4 precursor						blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)													---	---	---	---
CERKL	375298	broad.mit.edu	37	2	182468750	182468751	+	Frame_Shift_Del	DEL	AT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:182468750_182468751delAT	uc002unx.2	-	2	395_396	c.294_295delAT	c.(292-297)ATATTCfs	p.I98fs	CERKL_uc002uny.2_Frame_Shift_Del_p.I98fs|CERKL_uc010zfm.1_Frame_Shift_Del_p.I98fs|CERKL_uc002unz.2_5'UTR|CERKL_uc002uoa.2_Frame_Shift_Del_p.I98fs|CERKL_uc002uob.2_5'UTR|CERKL_uc002uoc.2_Frame_Shift_Del_p.I98fs|CERKL_uc010frk.2_RNA|CERKL_uc002uod.1_5'UTR|CERKL_uc002uoe.2_Frame_Shift_Del_p.I98fs	NM_001030311	NP_001025482	Q49MI3	CERKL_HUMAN	ceramide kinase-like isoform b	98_99					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|endoplasmic reticulum|Golgi apparatus|Golgi apparatus|nucleolus|nucleolus	diacylglycerol kinase activity			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.088)															---	---	---	---
DNAJC10	54431	broad.mit.edu	37	2	183608461	183608461	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:183608461delA	uc002uow.1	+						DNAJC10_uc002uox.1_Intron|DNAJC10_uc002uoy.1_Intron|DNAJC10_uc002uoz.1_Intron|DNAJC10_uc010fro.1_Intron	NM_018981	NP_061854			DnaJ (Hsp40) homolog, subfamily C, member 10						apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|ER-associated protein catabolic process|glycerol ether metabolic process|negative regulation of protein phosphorylation|protein folding|response to endoplasmic reticulum stress	endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|extracellular region	ATPase activator activity|ATPase binding|chaperone binding|electron carrier activity|heat shock protein binding|misfolded protein binding|protein disulfide oxidoreductase activity|unfolded protein binding			ovary(1)|large_intestine(1)|breast(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)															---	---	---	---
NCKAP1	10787	broad.mit.edu	37	2	183793729	183793729	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:183793729delT	uc002upc.2	-						NCKAP1_uc002upb.2_Intron	NM_013436	NP_038464			NCK-associated protein 1 isoform 1						apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)															---	---	---	---
NUP35	129401	broad.mit.edu	37	2	183993328	183993331	+	Intron	DEL	AAAA	-	-	rs71407008		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:183993328_183993331delAAAA	uc002upf.2	+						NUP35_uc010zfs.1_Intron|NUP35_uc010zft.1_Intron|NUP35_uc002upg.2_Intron	NM_138285	NP_612142			nucleoporin 35kDa						carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	intermediate filament cytoskeleton|nuclear membrane|nuclear pore|plasma membrane					0																		---	---	---	---
ZC3H15	55854	broad.mit.edu	37	2	187365029	187365029	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:187365029delA	uc002upo.2	+							NM_018471	NP_060941			erythropoietin 4 immediate early response							cytoplasm|nucleolus|plasma membrane	nucleic acid binding|zinc ion binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Epithelial(96;0.0922)|all cancers(119;0.233)															---	---	---	---
ITGAV	3685	broad.mit.edu	37	2	187524043	187524044	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:187524043_187524044insT	uc002upq.2	+						ITGAV_uc010frs.2_Intron|ITGAV_uc010zfv.1_Intron	NM_002210	NP_002201			integrin alpha-V isoform 1 precursor						angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)														---	---	---	---
CALCRL	10203	broad.mit.edu	37	2	188224010	188224010	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:188224010delA	uc002upv.3	-						CALCRL_uc010frt.2_Intron	NM_005795	NP_005786			calcitonin receptor-like precursor							integral to plasma membrane				lung(3)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(96;0.227)															---	---	---	---
COL5A2	1290	broad.mit.edu	37	2	189909977	189909977	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:189909977delA	uc002uqk.2	-						COL5A2_uc010frx.2_Intron	NM_000393	NP_000384			alpha 2 type V collagen preproprotein						axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)															---	---	---	---
STAT1	6772	broad.mit.edu	37	2	191857520	191857521	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:191857520_191857521delTT	uc002usj.2	-						STAT1_uc010fse.1_Intron|STAT1_uc002usk.2_Intron|STAT1_uc002usl.2_Intron|STAT1_uc010fsf.1_Intron	NM_007315	NP_009330			signal transducer and activator of transcription						activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			lung(3)|breast(3)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)													---	---	---	---
DNAH7	56171	broad.mit.edu	37	2	196765317	196765317	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:196765317delA	uc002utj.3	-							NM_018897	NP_061720			dynein, axonemal, heavy chain 7						ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12																		---	---	---	---
HECW2	57520	broad.mit.edu	37	2	197092733	197092733	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:197092733delA	uc002utm.1	-						HECW2_uc002utl.1_Intron	NM_020760	NP_065811			HECT, C2 and WW domain containing E3 ubiquitin						protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18																		---	---	---	---
CCDC150	284992	broad.mit.edu	37	2	197597021	197597021	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:197597021delT	uc002utp.1	+						CCDC150_uc010zgs.1_Intron	NM_001080539	NP_001074008			coiled-coil domain containing 150												0																		---	---	---	---
GTF3C3	9330	broad.mit.edu	37	2	197649518	197649518	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:197649518delA	uc002uts.2	-						GTF3C3_uc010zgu.1_Intron|GTF3C3_uc002utu.2_Intron|GTF3C3_uc002utt.3_Intron	NM_012086	NP_036218			general transcription factor IIIC, polypeptide							transcription factor TFIIIC complex	DNA binding|protein binding			ovary(3)|breast(3)|pancreas(1)	7																		---	---	---	---
COQ10B	80219	broad.mit.edu	37	2	198318518	198318518	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:198318518delT	uc002uuh.1	+						COQ10B_uc010fsl.1_5'Flank	NM_025147	NP_079423			coenzyme Q10 homolog B precursor							mitochondrial inner membrane					0			Epithelial(96;0.231)|OV - Ovarian serous cystadenocarcinoma(117;0.246)															---	---	---	---
HSPD1	3329	broad.mit.edu	37	2	198360213	198360214	+	Intron	DEL	AT	-	-	rs13432424		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:198360213_198360214delAT	uc002uui.2	-						HSPD1_uc002uuj.2_Intron|HSPD1_uc010zgx.1_Intron|HSPD1_uc010fsm.2_5'UTR|HSPD1_uc002uuk.2_Intron	NM_002156	NP_002147			chaperonin						'de novo' protein folding|activation of caspase activity|B cell cytokine production|B cell proliferation|chaperone-mediated protein complex assembly|interspecies interaction between organisms|isotype switching to IgG isotypes|MyD88-dependent toll-like receptor signaling pathway|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of interferon-alpha production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of macrophage activation|positive regulation of T cell activation|positive regulation of T cell mediated immune response to tumor cell|protein maturation|protein refolding|protein stabilization|response to unfolded protein|T cell activation	cell surface|coated pit|coated vesicle|cytosol|early endosome|extracellular space|lipopolysaccharide receptor complex|mitochondrial inner membrane|mitochondrial matrix|stored secretory granule	ATP binding|ATPase activity|cell surface binding|chaperone binding|DNA replication origin binding|lipopolysaccharide binding|p53 binding|single-stranded DNA binding				0			Epithelial(96;0.225)															---	---	---	---
MOBKL3	25843	broad.mit.edu	37	2	198404920	198404920	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:198404920delT	uc002uun.3	+						MOBKL3_uc002uum.3_Intron|MOBKL3_uc010fsn.2_Intron|MOBKL3_uc010fso.2_Intron|MOBKL3_uc010zgz.1_Intron	NM_015387	NP_056202			Mps One Binder kinase activator-like 3 isoform						transport	Golgi cisterna membrane|perinuclear region of cytoplasm	metal ion binding|protein binding				0			Epithelial(96;0.225)															---	---	---	---
RFTN2	130132	broad.mit.edu	37	2	198540351	198540354	+	5'UTR	DEL	AAAC	-	-	rs148812496		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:198540351_198540354delAAAC	uc002uuo.3	-	1						NM_144629	NP_653230			raftlin family member 2							plasma membrane					0																		---	---	---	---
BOLL	66037	broad.mit.edu	37	2	198593345	198593345	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:198593345delA	uc002uus.2	-						uc002uup.2_Intron|BOLL_uc002uur.2_Intron|BOLL_uc002uut.2_Intron|BOLL_uc010zha.1_Intron|BOLL_uc002uuu.1_Intron	NM_033030	NP_149019			boule isoform 2						cell differentiation|meiosis|multicellular organismal development|positive regulation of translational initiation|spermatogenesis	cytoplasm	nucleotide binding|protein binding|RNA binding|translation activator activity			ovary(2)	2																		---	---	---	---
BOLL	66037	broad.mit.edu	37	2	198643530	198643531	+	Intron	DEL	AC	-	-	rs140189200		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:198643530_198643531delAC	uc002uus.2	-						BOLL_uc002uur.2_Intron|BOLL_uc002uut.2_Intron|BOLL_uc010zha.1_Intron|BOLL_uc002uuu.1_Intron	NM_033030	NP_149019			boule isoform 2						cell differentiation|meiosis|multicellular organismal development|positive regulation of translational initiation|spermatogenesis	cytoplasm	nucleotide binding|protein binding|RNA binding|translation activator activity			ovary(2)	2																		---	---	---	---
SATB2	23314	broad.mit.edu	37	2	200193649	200193649	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:200193649delA	uc002uuy.1	-						SATB2_uc010fsq.1_Intron|SATB2_uc002uuz.1_Intron|SATB2_uc002uva.1_Intron	NM_015265	NP_056080			SATB homeobox 2							cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			ovary(1)	1																		---	---	---	---
C2orf60	129450	broad.mit.edu	37	2	200803916	200803917	+	Intron	DEL	TC	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:200803916_200803917delTC	uc002uvi.3	-						C2orf60_uc002uvj.3_Intron|C2orf60_uc002uvk.3_Intron|C2orf60_uc010fss.2_Intron	NM_001039693	NP_001034782			hypothetical protein LOC129450						wybutosine biosynthetic process		iron ion binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein homodimerization activity|tRNA binding				0																		---	---	---	---
SGOL2	151246	broad.mit.edu	37	2	201437004	201437004	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:201437004delT	uc002uvw.2	+	7	2048	c.1935delT	c.(1933-1935)AATfs	p.N645fs	SGOL2_uc010zhd.1_Frame_Shift_Del_p.N645fs|SGOL2_uc010zhe.1_Frame_Shift_Del_p.N645fs	NM_152524	NP_689737	Q562F6	SGOL2_HUMAN	shugoshin-like 2 isoform 1	645					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			ovary(2)|skin(2)	4																		---	---	---	---
AOX1	316	broad.mit.edu	37	2	201495240	201495240	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:201495240delA	uc002uvx.2	+						AOX1_uc010zhf.1_Intron|AOX1_uc010fsu.2_Intron	NM_001159	NP_001150			aldehyde oxidase 1						inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)													---	---	---	---
BZW1	9689	broad.mit.edu	37	2	201683505	201683505	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:201683505delA	uc010zhg.1	+	9	995	c.943delA	c.(943-945)AAAfs	p.K315fs	BZW1_uc002uwc.2_Frame_Shift_Del_p.K283fs	NM_014670	NP_055485	Q7L1Q6	BZW1_HUMAN	basic leucine zipper and W2 domains 1	283	W2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	protein binding				0																		---	---	---	---
NIF3L1	60491	broad.mit.edu	37	2	201758150	201758150	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:201758150delT	uc002uwm.2	+						NIF3L1_uc002uwl.2_Intron|NIF3L1_uc002uwn.2_Intron|NIF3L1_uc002uwo.2_Intron|NIF3L1_uc002uwp.2_Intron|NIF3L1_uc002uwq.2_Intron	NM_001136039	NP_001129511			NIF3 NGG1 interacting factor 3-like 1 isoform 1						positive regulation of transcription, DNA-dependent		transcription factor binding			skin(1)	1																		---	---	---	---
ORC2L	4999	broad.mit.edu	37	2	201798562	201798563	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:201798562_201798563insA	uc002uwr.2	-						ORC2L_uc010zhj.1_Intron	NM_006190	NP_006181			origin recognition complex, subunit 2						cell cycle checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	DNA replication origin binding|protein binding				0																		---	---	---	---
CASP10	843	broad.mit.edu	37	2	202082648	202082648	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:202082648delT	uc002uxl.1	+						CASP10_uc002uxj.1_3'UTR|CASP10_uc002uxk.1_3'UTR|CASP10_uc010fta.1_3'UTR|CASP10_uc002uxm.1_Intron|CASP10_uc010ftb.1_RNA	NM_032974	NP_116756			caspase 10 isoform b preproprotein						apoptosis|induction of apoptosis by extracellular signals|proteolysis	cytosol|plasma membrane	cysteine-type endopeptidase activity|identical protein binding|protein binding			skin(3)|ovary(1)|pancreas(1)|breast(1)	6																		---	---	---	---
NBEAL1	65065	broad.mit.edu	37	2	204037335	204037335	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:204037335delA	uc002uzt.3	+						NBEAL1_uc002uzs.3_Intron	NM_001114132	NP_001107604			neurobeachin-like 1 isoform 3								binding			ovary(1)|skin(1)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	2	204499475	204499475	+	IGR	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:204499475delG								RAPH1 (99417 upstream) : CD28 (71723 downstream)																																			---	---	---	---
PARD3B	117583	broad.mit.edu	37	2	206166298	206166298	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:206166298delA	uc002var.1	+	18	2710	c.2503delA	c.(2503-2505)AAAfs	p.K835fs	PARD3B_uc010fub.1_Frame_Shift_Del_p.K835fs|PARD3B_uc002vao.1_Frame_Shift_Del_p.K835fs|PARD3B_uc002vap.1_Frame_Shift_Del_p.K773fs|PARD3B_uc002vaq.1_Frame_Shift_Del_p.K766fs	NM_152526	NP_689739	Q8TEW8	PAR3L_HUMAN	par-3 partitioning defective 3 homolog B isoform	835	Lys-rich.				cell cycle|cell division	endomembrane system|tight junction				skin(2)|ovary(1)|breast(1)	4		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)														---	---	---	---
NDUFS1	4719	broad.mit.edu	37	2	207007366	207007366	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:207007366delA	uc002vbe.2	-						NDUFS1_uc010ziq.1_Intron|NDUFS1_uc010zir.1_Intron|NDUFS1_uc010zis.1_Intron|NDUFS1_uc010zit.1_Intron|NDUFS1_uc010ziu.1_Intron	NM_005006	NP_004997			NADH dehydrogenase (ubiquinone) Fe-S protein 1,						apoptosis|ATP metabolic process|mitochondrial electron transport, NADH to ubiquinone|reactive oxygen species metabolic process|regulation of mitochondrial membrane potential|transport	mitochondrial intermembrane space|mitochondrial respiratory chain complex I	2 iron, 2 sulfur cluster binding|4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NADH dehydrogenase (ubiquinone) activity|protein binding			ovary(1)	1					NADH(DB00157)													---	---	---	---
ADAM23	8745	broad.mit.edu	37	2	207308784	207308784	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:207308784delG	uc002vbq.2	+	1	417	c.194delG	c.(193-195)TGGfs	p.W65fs	ADAM23_uc010ziv.1_5'Flank	NM_003812	NP_003803	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23 preproprotein	65					cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)														---	---	---	---
ADAM23	8745	broad.mit.edu	37	2	207310055	207310055	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:207310055delA	uc002vbq.2	+	2	462	c.239delA	c.(238-240)GAAfs	p.E80fs	ADAM23_uc010ziv.1_RNA	NM_003812	NP_003803	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23 preproprotein	80					cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)														---	---	---	---
FAM119A	151194	broad.mit.edu	37	2	208477876	208477878	+	In_Frame_Del	DEL	AAG	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:208477876_208477878delAAG	uc002vcf.2	-	4	709_711	c.549_551delCTT	c.(547-552)TTCTTA>TTA	p.F183del	FAM119A_uc002vce.2_Intron|FAM119A_uc010fuk.1_In_Frame_Del_p.F183del|FAM119A_uc002vcg.3_In_Frame_Del_p.F183del	NM_145280	NP_660323	Q8WXB1	MT21A_HUMAN	hypothetical protein LOC151194	183						integral to membrane	methyltransferase activity				0				LUSC - Lung squamous cell carcinoma(261;0.0705)|Epithelial(149;0.131)|Lung(261;0.135)														---	---	---	---
CRYGA	1418	broad.mit.edu	37	2	209028422	209028422	+	5'Flank	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:209028422delT	uc002vcq.3	-							NM_014617	NP_055432			crystallin, gamma A						visual perception		structural constituent of eye lens				0				Epithelial(149;0.067)|LUSC - Lung squamous cell carcinoma(261;0.0708)|Lung(261;0.135)														---	---	---	---
PIKFYVE	200576	broad.mit.edu	37	2	209138183	209138183	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:209138183delA	uc002vcz.2	+						PIKFYVE_uc010fun.1_Intron|PIKFYVE_uc002vcy.1_Intron|PIKFYVE_uc002vcv.2_Intron|PIKFYVE_uc002vcw.2_Intron|PIKFYVE_uc002vcx.2_Intron	NM_015040	NP_055855			phosphatidylinositol-3-phosphate 5-kinase type						cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10																		---	---	---	---
PIKFYVE	200576	broad.mit.edu	37	2	209217247	209217247	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:209217247delT	uc002vcz.2	+							NM_015040	NP_055855			phosphatidylinositol-3-phosphate 5-kinase type						cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10																		---	---	---	---
UNC80	285175	broad.mit.edu	37	2	210658325	210658325	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:210658325delA	uc010zjc.1	+						UNC80_uc002vdj.1_Intron	NM_032504	NP_115893			chromosome 2 open reading frame 21 isoform 1							integral to membrane					0																		---	---	---	---
C2orf67	151050	broad.mit.edu	37	2	210887680	210887680	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:210887680delT	uc002vds.2	-	15	3165	c.2957delA	c.(2956-2958)AATfs	p.N986fs	C2orf67_uc002vdt.2_Frame_Shift_Del_p.N944fs	NM_152519	NP_689732	A0AUZ9	CB067_HUMAN	hypothetical protein LOC151050	986										ovary(3)	3		Renal(323;0.202)		Epithelial(149;0.00435)|Lung(261;0.0529)|LUSC - Lung squamous cell carcinoma(261;0.0551)|all cancers(144;0.0696)														---	---	---	---
ABCA12	26154	broad.mit.edu	37	2	215812346	215812346	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:215812346delA	uc002vew.2	-						ABCA12_uc002vev.2_Intron|ABCA12_uc010zjn.1_Intron	NM_173076	NP_775099			ATP-binding cassette, sub-family A, member 12						cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)														---	---	---	---
ABCA12	26154	broad.mit.edu	37	2	215823928	215823929	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:215823928_215823929delTT	uc002vew.2	-						ABCA12_uc002vev.2_Intron|ABCA12_uc010zjn.1_Intron	NM_173076	NP_775099			ATP-binding cassette, sub-family A, member 12						cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)														---	---	---	---
ABCA12	26154	broad.mit.edu	37	2	215843441	215843442	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:215843441_215843442insT	uc002vew.2	-						ABCA12_uc002vev.2_Intron|ABCA12_uc010zjn.1_Intron	NM_173076	NP_775099			ATP-binding cassette, sub-family A, member 12						cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)														---	---	---	---
ATIC	471	broad.mit.edu	37	2	216209431	216209432	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:216209431_216209432insA	uc002vex.3	+						ATIC_uc010zjo.1_Intron|ATIC_uc002vey.3_Intron	NM_004044	NP_004035			5-aminoimidazole-4-carboxamide ribonucleotide						IMP biosynthetic process|purine base metabolic process	cytosol	IMP cyclohydrolase activity|phosphoribosylaminoimidazolecarboxamide formyltransferase activity|protein homodimerization activity		ATIC/ALK(24)	haematopoietic_and_lymphoid_tissue(22)|ovary(2)|lung(2)|soft_tissue(2)|skin(1)	29		Renal(323;0.229)		Epithelial(149;2.02e-06)|all cancers(144;0.000316)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.0097)	Tetrahydrofolic acid(DB00116)			T	ALK	ALCL								---	---	---	---
FN1	2335	broad.mit.edu	37	2	216286749	216286749	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:216286749delA	uc002vfa.2	-						FN1_uc002vfb.2_Intron|FN1_uc002vfc.2_Intron|FN1_uc002vfd.2_Intron|FN1_uc002vfe.2_Intron|FN1_uc002vff.2_Intron|FN1_uc002vfg.2_Intron|FN1_uc002vfh.2_Intron|FN1_uc002vfi.2_Intron|FN1_uc002vfj.2_Intron|FN1_uc002vfl.2_Intron	NM_212482	NP_997647			fibronectin 1 isoform 1 preproprotein						acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
VIL1	7429	broad.mit.edu	37	2	219305309	219305310	+	Intron	DEL	GT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:219305309_219305310delGT	uc002via.2	+						VIL1_uc010zke.1_Intron|VIL1_uc002vib.2_Intron	NM_007127	NP_009058			villin 1						actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)														---	---	---	---
CCDC108	255101	broad.mit.edu	37	2	219892637	219892637	+	Frame_Shift_Del	DEL	G	-	-	rs144433350		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:219892637delG	uc002vjl.1	-	13	2030	c.1946delC	c.(1945-1947)CCGfs	p.P649fs	CCDC108_uc010fwa.1_Frame_Shift_Del_p.P92fs|CCDC108_uc010zkp.1_Frame_Shift_Del_p.P638fs|CCDC108_uc010zkq.1_Frame_Shift_Del_p.P584fs	NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	649						integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)														---	---	---	---
STK11IP	114790	broad.mit.edu	37	2	220470828	220470828	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:220470828delC	uc002vml.2	+						STK11IP_uc010zlk.1_Intron|STK11IP_uc010zll.1_Intron|STK11IP_uc002vmm.1_Intron	NM_052902	NP_443134			LKB1 interacting protein						protein localization	cytoplasm	protein kinase binding			ovary(1)	1		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)												OREG0003992	type=REGULATORY REGION|Gene=STK11IP|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	---	---	---	---
EPHA4	2043	broad.mit.edu	37	2	222320203	222320204	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:222320203_222320204insA	uc002vmq.2	-						EPHA4_uc002vmr.2_Intron|EPHA4_uc010zlm.1_Intron|EPHA4_uc010zln.1_Intron	NM_004438	NP_004429			ephrin receptor EphA4 precursor							integral to plasma membrane	ATP binding|ephrin receptor activity			lung(6)|large_intestine(2)|central_nervous_system(2)|urinary_tract(1)|skin(1)	12		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)														---	---	---	---
DOCK10	55619	broad.mit.edu	37	2	225661961	225661961	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:225661961delT	uc010fwz.1	-						DOCK10_uc002vob.2_Intron|DOCK10_uc002voa.2_Intron|DOCK10_uc002voc.2_Intron	NM_014689	NP_055504			dedicator of cytokinesis 10								GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)														---	---	---	---
Unknown	0	broad.mit.edu	37	2	228292826	228292829	+	IGR	DEL	CCTT	-	-	rs13030915		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:228292826_228292829delCCTT								TM4SF20 (48804 upstream) : AGFG1 (44059 downstream)																																			---	---	---	---
SP110	3431	broad.mit.edu	37	2	231034021	231034021	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:231034021delT	uc002vqh.3	-						SP110_uc002vqg.3_Intron	NM_004509	NP_004500			SP110 nuclear body protein isoform a						interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|signal transducer activity|zinc ion binding			ovary(2)|breast(2)	4		Renal(207;0.0112)|all_lung(227;0.0223)|Lung NSC(271;0.0983)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.169)		Epithelial(121;2.61e-12)|all cancers(144;6.39e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.0097)														---	---	---	---
ARL4C	10123	broad.mit.edu	37	2	235404565	235404568	+	3'UTR	DEL	CATC	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:235404565_235404568delCATC	uc002vvn.2	-	1					ARL4C_uc002vvm.3_Intron	NM_005737	NP_005728			ADP-ribosylation factor-like 4C						endocytic recycling|small GTPase mediated signal transduction	cytoplasm|filopodium|nucleus|plasma membrane	alpha-tubulin binding|GTP binding|GTPase activity			skin(1)	1		Breast(86;0.000596)|Renal(207;0.00339)|all_lung(227;0.00354)|all_hematologic(139;0.0494)|Lung NSC(271;0.0496)|Lung SC(224;0.164)|all_neural(83;0.173)		Epithelial(121;2.6e-19)|BRCA - Breast invasive adenocarcinoma(100;0.000296)|Lung(119;0.002)|LUSC - Lung squamous cell carcinoma(224;0.0048)														---	---	---	---
ILKAP	80895	broad.mit.edu	37	2	239079047	239079047	+	3'UTR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:239079047delA	uc002vxv.2	-	12					ILKAP_uc010zns.1_3'UTR|ILKAP_uc002vxw.2_3'UTR	NM_030768	NP_110395			integrin-linked kinase-associated protein							cytoplasm|protein serine/threonine phosphatase complex	metal ion binding|protein binding			ovary(3)	3		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_lung(227;0.152)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;5.49e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.93e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.82e-08)|BRCA - Breast invasive adenocarcinoma(100;0.00012)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0163)														---	---	---	---
SNED1	25992	broad.mit.edu	37	2	241992108	241992112	+	Intron	DEL	GGGGG	-	-	rs72462767		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:241992108_241992112delGGGGG	uc002wah.1	+							NM_001080437	NP_001073906			6720455I24Rik homolog precursor						cell-matrix adhesion	extracellular region	calcium ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(19;7.48e-31)|all_epithelial(40;1.35e-12)|Breast(86;0.000148)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;6.46e-32)|all cancers(36;6.23e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.1e-14)|Kidney(56;6.35e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.98e-08)|BRCA - Breast invasive adenocarcinoma(100;3.66e-06)|Lung(119;0.00072)|LUSC - Lung squamous cell carcinoma(224;0.00553)|Colorectal(34;0.0162)|COAD - Colon adenocarcinoma(134;0.109)														---	---	---	---
PPP1R7	5510	broad.mit.edu	37	2	242092999	242092999	+	Frame_Shift_Del	DEL	G	-	-	rs140300724		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:242092999delG	uc002wat.1	+	2	176	c.161delG	c.(160-162)CGGfs	p.R54fs	PPP1R7_uc010fzm.1_Frame_Shift_Del_p.R38fs|PPP1R7_uc002war.2_Frame_Shift_Del_p.R54fs|PPP1R7_uc002was.2_Frame_Shift_Del_p.R54fs|PPP1R7_uc002wau.1_Intron|PPP1R7_uc002wav.1_5'UTR	NM_002712	NP_002703	Q15435	PP1R7_HUMAN	protein phosphatase 1, regulatory subunit 7	54						cytoplasm|nucleus	protein binding|protein phosphatase type 1 regulator activity			ovary(3)	3		all_cancers(19;6.1e-33)|all_epithelial(40;1.07e-13)|Breast(86;0.000141)|Renal(207;0.00528)|all_lung(227;0.0446)|Ovarian(221;0.104)|Lung NSC(271;0.115)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;6.92e-32)|all cancers(36;5.35e-29)|OV - Ovarian serous cystadenocarcinoma(60;3.4e-14)|Kidney(56;4.23e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.24e-08)|BRCA - Breast invasive adenocarcinoma(100;3.56e-06)|Lung(119;0.000588)|LUSC - Lung squamous cell carcinoma(224;0.0048)|Colorectal(34;0.0137)|COAD - Colon adenocarcinoma(134;0.096)														---	---	---	---
FARP2	9855	broad.mit.edu	37	2	242373450	242373450	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:242373450delA	uc002wbi.1	+						FARP2_uc010zoq.1_Intron|FARP2_uc010zor.1_Intron	NM_014808	NP_055623			FERM, RhoGEF and pleckstrin domain protein 2						axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)														---	---	---	---
RAD18	56852	broad.mit.edu	37	3	8944121	8944121	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:8944121delT	uc003brd.2	-	10	1188	c.1111delA	c.(1111-1113)ACAfs	p.T371fs	RAD18_uc003bre.2_RNA	NM_020165	NP_064550	Q9NS91	RAD18_HUMAN	postreplication repair protein hRAD18p	371					DNA repair	nucleus|replication fork	damaged DNA binding|ligase activity|ubiquitin protein ligase binding|Y-form DNA binding|zinc ion binding			skin(3)|ovary(2)	5				OV - Ovarian serous cystadenocarcinoma(96;0.0552)									Rad6_pathway					---	---	---	---
IL17RE	132014	broad.mit.edu	37	3	9953106	9953106	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:9953106delC	uc003btu.2	+						CIDEC_uc003bto.2_Intron|IL17RE_uc011atn.1_Intron|IL17RE_uc003btw.2_Intron|IL17RE_uc003btx.2_Intron|IL17RE_uc010hcq.2_Intron|IL17RE_uc003bty.2_Intron	NM_153483	NP_705616			interleukin 17 receptor E isoform 1							cytoplasm|extracellular region|integral to membrane	receptor activity			central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(96;5.34e-64)														---	---	---	---
PRRT3	285368	broad.mit.edu	37	3	9991859	9991859	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:9991859delA	uc003bul.2	-						CIDEC_uc003bto.2_Intron|PRRT3_uc003buk.2_Intron|PRRT3_uc003bum.2_Intron	NM_207351	NP_997234			proline-rich transmembrane protein 3 precursor							integral to membrane					0																		---	---	---	---
FANCD2	2177	broad.mit.edu	37	3	10081677	10081678	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:10081677_10081678delAA	uc003buw.2	+						FANCD2_uc003bux.1_Intron|FANCD2_uc003buy.1_Intron|FANCD2_uc003buv.2_3'UTR	NM_033084	NP_149075			Fanconi anemia complementation group D2 isoform						DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)				D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				---	---	---	---
SLC6A1	6529	broad.mit.edu	37	3	11067785	11067785	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:11067785delA	uc010hdq.2	+							NM_003042	NP_003033			solute carrier family 6 (neurotransmitter						neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(1)|skin(1)	2		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)													---	---	---	---
VGLL4	9686	broad.mit.edu	37	3	11685144	11685144	+	Intron	DEL	A	-	-	rs72268569		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:11685144delA	uc003bwf.2	-						VGLL4_uc010hdx.1_5'UTR|VGLL4_uc003bwg.2_Intron	NM_014667	NP_055482			vestigial like 4 isoform b						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1				LUSC - Lung squamous cell carcinoma(1;0.089)|Lung(1;0.111)														---	---	---	---
Unknown	0	broad.mit.edu	37	3	11923145	11923145	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:11923145delA								C3orf31 (34793 upstream) : SYN2 (122717 downstream)																																			---	---	---	---
RAF1	5894	broad.mit.edu	37	3	12659890	12659890	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:12659890delA	uc003bxf.3	-						RAF1_uc011auu.1_Intron	NM_002880	NP_002871			v-raf-1 murine leukemia viral oncogene homolog						activation of MAPKK activity|apoptosis|axon guidance|cell proliferation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of protein complex assembly|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of peptidyl-serine phosphorylation|Ras protein signal transduction|synaptic transmission	cytosol|mitochondrial outer membrane|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|receptor signaling protein activity		ESRP1/RAF1(4)|SRGAP3/RAF1(4)	central_nervous_system(4)|prostate(4)|lung(2)|upper_aerodigestive_tract(1)|stomach(1)|liver(1)|ovary(1)	14					Sorafenib(DB00398)			T	SRGAP3	pilocytic astrocytoma				Noonan_syndrome				---	---	---	---
CAPN7	23473	broad.mit.edu	37	3	15288743	15288746	+	Intron	DEL	TTTT	-	-	rs113032469		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:15288743_15288746delTTTT	uc003bzn.2	+							NM_014296	NP_055111			calpain 7						proteolysis	nucleus	calcium-dependent cysteine-type endopeptidase activity			ovary(1)	1																		---	---	---	---
ANKRD28	23243	broad.mit.edu	37	3	15756051	15756055	+	Intron	DEL	AAAAC	-	-	rs142022972		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:15756051_15756055delAAAAC	uc003caj.1	-						ANKRD28_uc003cai.1_Intron|ANKRD28_uc011avz.1_Intron|ANKRD28_uc003cak.1_Intron|ANKRD28_uc011awa.1_Intron|ANKRD28_uc003cal.1_Intron|ANKRD28_uc003cam.2_Intron	NM_015199	NP_056014			ankyrin repeat domain 28							nucleoplasm	protein binding			breast(1)	1																		---	---	---	---
DAZL	1618	broad.mit.edu	37	3	16639875	16639875	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:16639875delA	uc003cbb.2	-						DAZL_uc003cba.2_Intron	NM_001351	NP_001342			deleted in azoospermia-like						germ cell development|multicellular organismal development|positive regulation of translational initiation|spermatogenesis	cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding|translation activator activity				0																		---	---	---	---
TBC1D5	9779	broad.mit.edu	37	3	17300086	17300086	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:17300086delA	uc003cbf.2	-						TBC1D5_uc010heu.2_Intron|TBC1D5_uc010hev.2_Intron|TBC1D5_uc003cbe.2_Intron|TBC1D5_uc010hew.1_Intron	NM_014744	NP_055559			TBC1 domain family, member 5 isoform b							intracellular	protein binding|Rab GTPase activator activity			ovary(1)	1																		---	---	---	---
KAT2B	8850	broad.mit.edu	37	3	20141300	20141301	+	Intron	DEL	AT	-	-	rs11128939	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:20141300_20141301delAT	uc003cbq.2	+							NM_003884	NP_003875			K(lysine) acetyltransferase 2B						cell cycle arrest|cellular response to insulin stimulus|chromatin remodeling|histone H3 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|negative regulation of cell proliferation|transcription initiation from RNA polymerase I promoter	Ada2/Gcn5/Ada3 transcription activator complex|chromatin remodeling complex|PCAF complex	cyclin-dependent protein kinase inhibitor activity|histone acetyltransferase activity|histone deacetylase binding|protein kinase binding|transcription coactivator activity|transcription factor binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3																		---	---	---	---
KAT2B	8850	broad.mit.edu	37	3	20194018	20194018	+	3'UTR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:20194018delT	uc003cbq.2	+	18						NM_003884	NP_003875			K(lysine) acetyltransferase 2B						cell cycle arrest|cellular response to insulin stimulus|chromatin remodeling|histone H3 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|negative regulation of cell proliferation|transcription initiation from RNA polymerase I promoter	Ada2/Gcn5/Ada3 transcription activator complex|chromatin remodeling complex|PCAF complex	cyclin-dependent protein kinase inhibitor activity|histone acetyltransferase activity|histone deacetylase binding|protein kinase binding|transcription coactivator activity|transcription factor binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3																		---	---	---	---
UBE2E1	7324	broad.mit.edu	37	3	23930592	23930593	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:23930592_23930593insT	uc003cch.2	+						UBE2E1_uc003cci.2_Intron|UBE2E1_uc011awh.1_Intron	NM_003341	NP_003332			ubiquitin-conjugating enzyme E2E 1 isoform 1						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|histone H2B ubiquitination|histone monoubiquitination|ISG15-protein conjugation|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K48-linked ubiquitination	cytosol|nucleoplasm|ubiquitin ligase complex	ATP binding|ISG15 ligase activity|protein binding|ubiquitin-protein ligase activity				0																		---	---	---	---
RARB	5915	broad.mit.edu	37	3	25470412	25470412	+	Intron	DEL	A	-	-	rs77824017		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:25470412delA	uc011awl.1	+						RARB_uc003cdi.1_Intron|RARB_uc003cdh.2_Intron	NM_016152	NP_057236			retinoic acid receptor, beta isoform 2						embryonic digestive tract development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	protein binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|large_intestine(1)|pancreas(1)	3					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tamibarotene(DB04942)|Tazarotene(DB00799)													---	---	---	---
NGLY1	55768	broad.mit.edu	37	3	25761839	25761840	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:25761839_25761840insT	uc003cdl.2	-						NGLY1_uc010hfg.2_Intron|NGLY1_uc003cdm.2_Intron|NGLY1_uc011awo.1_Intron|NGLY1_uc003cdk.2_Intron	NM_018297	NP_060767			N-glycanase 1 isoform 1						glycoprotein catabolic process	cytoplasm	metal ion binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding			breast(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	3	27047737	27047737	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:27047737delT								LRRC3B (295474 upstream) : NEK10 (104658 downstream)																																			---	---	---	---
ZCWPW2	152098	broad.mit.edu	37	3	28489611	28489611	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:28489611delA	uc003ceh.2	+						ZCWPW2_uc003cei.2_Intron|ZCWPW2_uc010hfo.2_Intron	NM_001040432	NP_001035522			zinc finger, CW type with PWWP domain 2								zinc ion binding			ovary(2)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	3	32072179	32072179	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:32072179delA								ZNF860 (39059 upstream) : GPD1L (75965 downstream)																																			---	---	---	---
CMTM8	152189	broad.mit.edu	37	3	32411484	32411484	+	3'UTR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:32411484delA	uc003cex.2	+	4					CMTM8_uc010hfu.2_3'UTR	NM_178868	NP_849199			CKLF-like MARVEL transmembrane domain containing						chemotaxis	extracellular space|integral to membrane	cytokine activity				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	3	32676649	32676649	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:32676649delT								DYNC1LI1 (64299 upstream) : CNOT10 (50049 downstream)																																			---	---	---	---
CLASP2	23122	broad.mit.edu	37	3	33602361	33602361	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:33602361delT	uc003cfu.2	-	27	3223	c.2869delA	c.(2869-2871)ATGfs	p.M957fs	CLASP2_uc003cfs.2_Frame_Shift_Del_p.M164fs|CLASP2_uc003cft.2_RNA|CLASP2_uc010hgb.2_RNA|CLASP2_uc011axt.1_Frame_Shift_Del_p.M557fs	NM_015097	NP_055912	B2RTR1	B2RTR1_HUMAN	CLIP-associating protein 2	966										ovary(3)|central_nervous_system(1)	4																		---	---	---	---
CLASP2	23122	broad.mit.edu	37	3	33648256	33648256	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:33648256delA	uc003cfu.2	-						CLASP2_uc003cft.2_Intron|CLASP2_uc010hgb.2_Intron|CLASP2_uc003cfv.2_Intron|CLASP2_uc011axu.1_Intron|CLASP2_uc003cfw.2_Intron|CLASP2_uc011axt.1_Intron	NM_015097	NP_055912			CLIP-associating protein 2											ovary(3)|central_nervous_system(1)	4																		---	---	---	---
CLASP2	23122	broad.mit.edu	37	3	33668576	33668576	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:33668576delA	uc003cfu.2	-						CLASP2_uc003cft.2_Intron|CLASP2_uc010hgb.2_Intron|CLASP2_uc003cfv.2_Intron|CLASP2_uc011axu.1_Intron|CLASP2_uc003cfw.2_Intron|CLASP2_uc011axt.1_5'Flank	NM_015097	NP_055912			CLIP-associating protein 2											ovary(3)|central_nervous_system(1)	4																		---	---	---	---
ARPP21	10777	broad.mit.edu	37	3	35729113	35729114	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:35729113_35729114delAA	uc003cgb.2	+						ARPP21_uc003cga.2_Intron|ARPP21_uc011axy.1_Intron|ARPP21_uc003cgf.2_5'Flank	NM_016300	NP_057384			cyclic AMP-regulated phosphoprotein, 21 kD							cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3																		---	---	---	---
Unknown	0	broad.mit.edu	37	3	36810381	36810382	+	IGR	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:36810381_36810382delTT								DCLK3 (29029 upstream) : TRANK1 (57929 downstream)																																			---	---	---	---
EPM2AIP1	9852	broad.mit.edu	37	3	37032586	37032586	+	3'UTR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:37032586delA	uc003cgk.2	-	1					MLH1_uc011aye.1_5'Flank|MLH1_uc003cgl.2_5'Flank|MLH1_uc011ayb.1_5'Flank|MLH1_uc010hge.2_5'Flank|MLH1_uc003cgn.3_5'Flank|MLH1_uc011ayc.1_5'Flank|MLH1_uc011ayd.1_5'Flank|MLH1_uc003cgo.2_5'Flank	NM_014805	NP_055620			EPM2A interacting protein 1							endoplasmic reticulum					0																		---	---	---	---
LRRFIP2	9209	broad.mit.edu	37	3	37105147	37105147	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:37105147delT	uc003cgp.2	-						MLH1_uc011aye.1_Intron|LRRFIP2_uc011ayf.1_Intron|LRRFIP2_uc003cgr.2_Intron|LRRFIP2_uc003cgs.3_Intron|LRRFIP2_uc003cgt.3_Intron	NM_006309	NP_006300			leucine rich repeat (in FLII) interacting						Wnt receptor signaling pathway		LRR domain binding			ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	3	37238346	37238346	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:37238346delA								LRRFIP2 (20495 upstream) : GOLGA4 (46392 downstream)																																			---	---	---	---
DLEC1	9940	broad.mit.edu	37	3	38093246	38093246	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:38093246delA	uc003cho.1	+						DLEC1_uc003chp.1_Intron|DLEC1_uc010hgv.1_Intron	NM_007335	NP_031361			deleted in lung and esophageal cancer 1 isoform						negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)														---	---	---	---
DLEC1	9940	broad.mit.edu	37	3	38163486	38163486	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:38163486delG	uc003cho.1	+						DLEC1_uc003chp.1_Intron|DLEC1_uc010hgv.1_Intron|DLEC1_uc003chr.1_Intron|DLEC1_uc003chs.1_Intron	NM_007335	NP_031361			deleted in lung and esophageal cancer 1 isoform						negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)														---	---	---	---
XYLB	9942	broad.mit.edu	37	3	38407303	38407303	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:38407303delG	uc003cic.2	+						XYLB_uc011ayp.1_Intron|XYLB_uc003cid.1_Intron	NM_005108	NP_005099			xylulokinase						D-xylose metabolic process|generation of precursor metabolites and energy|xylulose catabolic process		ATP binding|xylulokinase activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.00372)|Kidney(284;0.00405)														---	---	---	---
RPSA	3921	broad.mit.edu	37	3	39452945	39452945	+	Intron	DEL	T	-	-	rs35233395		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:39452945delT	uc003cjp.2	+						RPSA_uc003cjq.2_Intron|RPSA_uc003cjr.2_Intron|RPSA_uc003cjt.2_Intron	NM_002295	NP_002286			ribosomal protein SA						cell adhesion|endocrine pancreas development|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit assembly|rRNA export from nucleus|translational elongation|translational termination|viral transcription	90S preribosome|cytosolic small ribosomal subunit|nucleus|plasma membrane	protein binding|receptor activity|ribosome binding|structural constituent of ribosome			lung(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0509)|Kidney(284;0.064)														---	---	---	---
Unknown	0	broad.mit.edu	37	3	40740450	40740450	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:40740450delA								ZNF621 (159407 upstream) : CTNNB1 (495951 downstream)																																			---	---	---	---
CCDC13	152206	broad.mit.edu	37	3	42798875	42798875	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:42798875delA	uc003cly.3	-						CCDC13_uc003clz.2_Intron|CCDC13_uc011azq.1_Intron	NM_144719	NP_653320			coiled-coil domain containing 13											ovary(1)	1																		---	---	---	---
SETD2	29072	broad.mit.edu	37	3	47087870	47087870	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:47087870delA	uc003cqs.2	-						SETD2_uc003cqv.2_Intron|SETD2_uc003cqr.2_Intron	NM_014159	NP_054878			SET domain containing 2						regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)				N|F|S|Mis		clear cell renal carcinoma								---	---	---	---
SETD2	29072	broad.mit.edu	37	3	47127923	47127923	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:47127923delA	uc003cqs.2	-						SETD2_uc003cqv.2_Intron|SETD2_uc003cqt.1_5'Flank	NM_014159	NP_054878			SET domain containing 2						regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)				N|F|S|Mis		clear cell renal carcinoma								---	---	---	---
PTPN23	25930	broad.mit.edu	37	3	47451532	47451532	+	Frame_Shift_Del	DEL	C	-	-	rs77776224	byFrequency	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:47451532delC	uc003crf.1	+	20	2340	c.2244delC	c.(2242-2244)CTCfs	p.L748fs	PTPN23_uc011baw.1_Frame_Shift_Del_p.L713fs|PTPN23_uc011bax.1_Intron|PTPN23_uc011bay.1_Frame_Shift_Del_p.L618fs	NM_015466	NP_056281	Q9H3S7	PTN23_HUMAN	protein tyrosine phosphatase, non-receptor type	748	Pro-rich.				cilium morphogenesis	cilium|cytoplasmic membrane-bounded vesicle|microtubule basal body	protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000271)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)														---	---	---	---
SCAP	22937	broad.mit.edu	37	3	47476328	47476329	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:47476328_47476329delAA	uc003crh.1	-						SCAP_uc011baz.1_Intron|SCAP_uc003crg.2_Intron	NM_012235	NP_036367			SREBF chaperone protein						cholesterol metabolic process|negative regulation of cholesterol biosynthetic process|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane	unfolded protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.00592)|Kidney(197;0.00679)														---	---	---	---
SMARCC1	6599	broad.mit.edu	37	3	47730746	47730746	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:47730746delA	uc003crq.2	-						SMARCC1_uc011bbd.1_Intron	NM_003074	NP_003065			SWI/SNF-related matrix-associated						chromatin remodeling|nervous system development|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex|WINAC complex	DNA binding|protein N-terminus binding|transcription coactivator activity			skin(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;7.47e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)														---	---	---	---
USP19	10869	broad.mit.edu	37	3	49155556	49155556	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49155556delA	uc003cwd.1	-						USP19_uc003cwa.2_5'Flank|USP19_uc003cvz.3_Intron|USP19_uc011bcg.1_Intron|USP19_uc003cwb.2_Intron|USP19_uc003cwc.1_5'Flank|USP19_uc011bch.1_Intron|USP19_uc011bci.1_Intron	NM_006677	NP_006668			ubiquitin thioesterase 19						ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(4)|breast(2)|lung(1)	7				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)														---	---	---	---
APEH	327	broad.mit.edu	37	3	49714427	49714427	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49714427delC	uc003cxf.2	+	10	1369	c.969delC	c.(967-969)ATCfs	p.I323fs	APEH_uc010hkw.1_Frame_Shift_Del_p.I323fs	NM_001640	NP_001631	P13798	ACPH_HUMAN	N-acylaminoacyl-peptide hydrolase	323					proteolysis	cytoplasm|nuclear membrane	serine-type endopeptidase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.53e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)														---	---	---	---
RBM6	10180	broad.mit.edu	37	3	49999865	49999866	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49999865_49999866delAA	uc003cyc.2	+						RBM6_uc011bdh.1_Intron|RBM6_uc010hlc.1_Intron|RBM6_uc003cyd.2_Intron|RBM6_uc003cye.2_Intron|RBM6_uc011bdi.1_Intron|RBM6_uc010hld.1_Intron|RBM6_uc010hle.1_Intron|RBM6_uc010hlf.1_Intron	NM_005777	NP_005768			RNA binding motif protein 6						RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)														---	---	---	---
RBM5	10181	broad.mit.edu	37	3	50138145	50138145	+	Intron	DEL	A	-	-	rs73835203	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:50138145delA	uc003cyg.2	+						RBM5_uc003cyf.2_3'UTR|RBM5_uc011bdj.1_Intron|RBM5_uc011bdk.1_Intron	NM_005778	NP_005769			RNA binding motif protein 5						apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)														---	---	---	---
DOCK3	1795	broad.mit.edu	37	3	51370853	51370854	+	Intron	DEL	AG	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:51370853_51370854delAG	uc011bds.1	+							NM_004947	NP_004938			dedicator of cytokinesis 3							cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)														---	---	---	---
DOCK3	1795	broad.mit.edu	37	3	51417604	51417604	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:51417604delC	uc011bds.1	+	52	5572	c.5549delC	c.(5548-5550)ACCfs	p.T1850fs		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1850						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)														---	---	---	---
VPRBP	9730	broad.mit.edu	37	3	51474928	51474928	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:51474928delA	uc003dbe.1	-							NM_014703	NP_055518			HIV-1 Vpr binding protein						interspecies interaction between organisms	cytoplasm|nucleus	protein binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000272)|Kidney(197;0.000729)|KIRC - Kidney renal clear cell carcinoma(197;0.000875)														---	---	---	---
PBRM1	55193	broad.mit.edu	37	3	52584693	52584694	+	Intron	DEL	CT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52584693_52584694delCT	uc003des.2	-						PBRM1_uc003dex.2_Intron|PBRM1_uc003deq.2_Intron|PBRM1_uc003der.2_Intron|PBRM1_uc003det.2_Intron|PBRM1_uc003deu.2_Intron|PBRM1_uc003dev.2_Intron|PBRM1_uc003dew.2_Intron|PBRM1_uc010hmk.1_Intron|PBRM1_uc003dey.2_Intron	NM_181042	NP_060635			polybromo 1 isoform 4						chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)				Mis|N|F|S|D|O		clear cell renal carcinoma|breast								---	---	---	---
PBRM1	55193	broad.mit.edu	37	3	52668500	52668500	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52668500delA	uc003des.2	-						PBRM1_uc003dex.2_Intron|PBRM1_uc003deq.2_Intron|PBRM1_uc003der.2_Intron|PBRM1_uc003det.2_Intron|PBRM1_uc003deu.2_Intron|PBRM1_uc003dev.2_Intron|PBRM1_uc003dew.2_Intron|PBRM1_uc010hmk.1_Intron|PBRM1_uc003dey.2_Intron|PBRM1_uc003dez.1_Intron|PBRM1_uc003dfb.1_Intron	NM_181042	NP_060635			polybromo 1 isoform 4						chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)				Mis|N|F|S|D|O		clear cell renal carcinoma|breast								---	---	---	---
NEK4	6787	broad.mit.edu	37	3	52768925	52768925	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52768925delA	uc003dfq.3	-						NEK4_uc011bej.1_Intron	NM_003157	NP_003148			NIMA-related kinase 4						cell division|mitosis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(1)	1				BRCA - Breast invasive adenocarcinoma(193;7.44e-05)|Kidney(197;0.000711)|KIRC - Kidney renal clear cell carcinoma(197;0.00086)|OV - Ovarian serous cystadenocarcinoma(275;0.0513)														---	---	---	---
SFMBT1	51460	broad.mit.edu	37	3	52952665	52952666	+	Intron	INS	-	TG	TG			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52952665_52952666insTG	uc003dgf.2	-						SFMBT1_uc010hmr.2_Intron|SFMBT1_uc003dgg.2_Intron|SFMBT1_uc003dgh.2_Intron	NM_001005159	NP_001005159			Scm-like with four mbt domains 1						regulation of transcription, DNA-dependent	nucleus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;9.91e-05)|Kidney(197;0.000644)|KIRC - Kidney renal clear cell carcinoma(197;0.000792)|OV - Ovarian serous cystadenocarcinoma(275;0.113)														---	---	---	---
CACNA2D3	55799	broad.mit.edu	37	3	54872838	54872838	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:54872838delT	uc003dhf.2	+						CACNA2D3_uc011beu.1_Intron|CACNA2D3_uc003dhg.1_Intron|CACNA2D3_uc003dhh.1_Intron|CACNA2D3_uc010hmv.1_Intron	NM_018398	NP_060868			calcium channel, voltage-dependent, alpha							integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			large_intestine(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)														---	---	---	---
CCDC66	285331	broad.mit.edu	37	3	56653283	56653283	+	Intron	DEL	T	-	-	rs113282062		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:56653283delT	uc003dhz.2	+						CCDC66_uc003dhy.2_Intron|CCDC66_uc003dhu.2_Intron|CCDC66_uc003dhx.2_Intron|CCDC66_uc003dia.2_Intron	NM_001141947	NP_001135419			coiled-coil domain containing 66 isoform 1											breast(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0478)|Kidney(284;0.0597)|OV - Ovarian serous cystadenocarcinoma(275;0.233)														---	---	---	---
APPL1	26060	broad.mit.edu	37	3	57276921	57276921	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:57276921delA	uc003dio.2	+	7	600	c.453delA	c.(451-453)TCAfs	p.S151fs	APPL1_uc010hnb.2_Frame_Shift_Del_p.S151fs|APPL1_uc011bey.1_Frame_Shift_Del_p.S134fs	NM_012096	NP_036228	Q9UKG1	DP13A_HUMAN	adaptor protein, phosphotyrosine interaction, PH	151	Required for RAB5A binding.				apoptosis|cell cycle|cell proliferation|insulin receptor signaling pathway|regulation of apoptosis|regulation of establishment of protein localization in plasma membrane|regulation of glucose import	cytosol|early endosome membrane|microsome|nucleus|vesicle membrane	protein kinase B binding			breast(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0124)|Kidney(284;0.0144)														---	---	---	---
DNAH12	201625	broad.mit.edu	37	3	57494742	57494742	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:57494742delT	uc003dit.2	-						DNAH12_uc003diu.2_Intron	NM_178504	NP_848599			dynein heavy chain domain 2 isoform 1						microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			pancreas(1)|skin(1)	2																		---	---	---	---
FAM116A	201627	broad.mit.edu	37	3	57619023	57619023	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:57619023delA	uc003dja.2	-	15	1393	c.1322delT	c.(1321-1323)TTGfs	p.L441fs		NM_152678	NP_689891	Q8IWF6	F116A_HUMAN	hypothetical protein LOC201627	441										pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(55;0.000621)|KIRC - Kidney renal clear cell carcinoma(284;0.0485)|Kidney(284;0.0607)														---	---	---	---
SLMAP	7871	broad.mit.edu	37	3	57882416	57882416	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:57882416delA	uc003dje.1	+						SLMAP_uc003djc.1_Intron|SLMAP_uc003djd.1_Intron|SLMAP_uc003djf.1_Intron|SLMAP_uc003djg.1_Intron|SLMAP_uc011bez.1_Intron|SLMAP_uc011bfa.1_Intron|SLMAP_uc003djh.2_Intron|SLMAP_uc003dji.1_Intron|SLMAP_uc011bfb.1_Intron|SLMAP_uc011bfc.1_Intron	NM_007159	NP_009090			sarcolemma associated protein						muscle contraction|protein folding	integral to plasma membrane|microtubule organizing center|prefoldin complex|sarcolemma|smooth endoplasmic reticulum	unfolded protein binding				0				BRCA - Breast invasive adenocarcinoma(55;0.000271)|KIRC - Kidney renal clear cell carcinoma(284;0.0602)|Kidney(284;0.0754)|OV - Ovarian serous cystadenocarcinoma(275;0.182)														---	---	---	---
PDHB	5162	broad.mit.edu	37	3	58416355	58416355	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:58416355delA	uc003dkf.3	-						PDHB_uc003dke.3_Intron|PDHB_uc003dkg.3_Intron|PDHB_uc010hnl.2_Intron|PDHB_uc011bff.1_Intron	NM_000925	NP_000916			pyruvate dehydrogenase (lipoamide) beta						glycolysis|regulation of acetyl-CoA biosynthetic process from pyruvate|tricarboxylic acid cycle	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(55;0.000179)|Kidney(10;0.00231)|KIRC - Kidney renal clear cell carcinoma(10;0.00258)|OV - Ovarian serous cystadenocarcinoma(275;0.187)	NADH(DB00157)|Pyruvic acid(DB00119)													---	---	---	---
PTPRG	5793	broad.mit.edu	37	3	62263202	62263202	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:62263202delT	uc003dlb.2	+						PTPRG_uc003dlc.2_Intron|PTPRG_uc011bfi.1_Intron|uc010hno.2_Intron|uc003dld.3_Intron|uc010hnp.2_Intron|uc003dle.3_Intron	NM_002841	NP_002832			protein tyrosine phosphatase, receptor type, G						transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(5)|lung(2)	7				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)														---	---	---	---
PTPRG	5793	broad.mit.edu	37	3	62278688	62278688	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:62278688delT	uc003dlb.2	+						PTPRG_uc003dlc.2_Intron|PTPRG_uc011bfi.1_Intron|uc010hno.2_Intron|uc003dld.3_Intron|uc010hnp.2_Intron|uc003dle.3_Intron	NM_002841	NP_002832			protein tyrosine phosphatase, receptor type, G						transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(5)|lung(2)	7				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)														---	---	---	---
CNTN3	5067	broad.mit.edu	37	3	74548736	74548737	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:74548736_74548737insA	uc003dpm.1	-							NM_020872	NP_065923			contactin 3 precursor						cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)														---	---	---	---
Unknown	0	broad.mit.edu	37	3	75465053	75465053	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:75465053delT								CNTN3 (894710 upstream) : FAM86D (5652 downstream)																																			---	---	---	---
FAM86D	692099	broad.mit.edu	37	3	75480039	75480040	+	5'UTR	INS	-	CA	CA	rs34306442		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:75480039_75480040insCA	uc003dpp.3	-	3					FAM86D_uc003dpo.3_RNA|FAM86D_uc003dps.3_RNA|FAM86D_uc003dpq.3_5'UTR|FAM86D_uc003dpr.3_RNA	NR_024241				RecName: Full=Protein FAM86B1;												0																		---	---	---	---
C3orf38	285237	broad.mit.edu	37	3	88202736	88202736	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:88202736delT	uc003dqw.2	+							NM_173824	NP_776185			hypothetical protein LOC285237						apoptosis						0		Lung NSC(201;0.17)		UCEC - Uterine corpus endometrioid carcinoma (27;0.194)|LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00661)														---	---	---	---
COL8A1	1295	broad.mit.edu	37	3	99513026	99513027	+	Intron	DEL	TC	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:99513026_99513027delTC	uc003dtg.1	+						COL8A1_uc003dth.1_Intron|COL8A1_uc003dti.1_Intron	NM_001850	NP_001841			alpha 1 type VIII collagen precursor						angiogenesis|cell adhesion	basement membrane|collagen type VIII					0																		---	---	---	---
C3orf26	84319	broad.mit.edu	37	3	99897121	99897121	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:99897121delT	uc003dtl.2	+							NM_032359	NP_115735			hypothetical protein LOC84319								ATP binding|ATP-dependent helicase activity|nucleic acid binding			skin(1)	1																		---	---	---	---
TOMM70A	9868	broad.mit.edu	37	3	100086754	100086754	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:100086754delT	uc003dtw.2	-							NM_014820	NP_055635			translocase of outer mitochondrial membrane 70						protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane translocase complex	protein binding|protein transmembrane transporter activity			ovary(1)	1																		---	---	---	---
ABI3BP	25890	broad.mit.edu	37	3	100581262	100581262	+	Intron	DEL	T	-	-	rs111307036		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:100581262delT	uc003dun.2	-						ABI3BP_uc003duo.2_Intron	NM_015429	NP_056244			ABI gene family, member 3 (NESH) binding protein							extracellular space				ovary(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)	4																		---	---	---	---
SENP7	57337	broad.mit.edu	37	3	101076431	101076431	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:101076431delA	uc003dut.2	-						SENP7_uc003duu.2_Intron|SENP7_uc003duv.2_Intron|SENP7_uc003duw.2_Intron|SENP7_uc003dux.2_Intron	NM_020654	NP_065705			sentrin/SUMO-specific protease 7 isoform 1						proteolysis	nucleus	cysteine-type peptidase activity			ovary(3)|lung(2)	5																		---	---	---	---
CEP97	79598	broad.mit.edu	37	3	101484459	101484459	+	3'UTR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:101484459delT	uc003dvk.1	+	11					CEP97_uc011bhf.1_3'UTR|CEP97_uc003dvl.1_3'UTR|CEP97_uc003dvm.1_3'UTR	NM_024548	NP_078824			centrosomal protein 97kDa							centrosome|nucleus	protein binding			ovary(2)	2																		---	---	---	---
DZIP3	9666	broad.mit.edu	37	3	108393164	108393165	+	Intron	INS	-	T	T	rs41267027	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:108393164_108393165insT	uc003dxd.2	+						DZIP3_uc003dxf.1_Intron|DZIP3_uc011bhm.1_Intron	NM_014648	NP_055463			DAZ interacting protein 3, zinc finger						protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
PHLDB2	90102	broad.mit.edu	37	3	111672933	111672933	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:111672933delG	uc010hqa.2	+						PHLDB2_uc003dyc.2_Intron|PHLDB2_uc003dyd.2_Intron|PHLDB2_uc003dyg.2_Intron|PHLDB2_uc003dyh.2_Intron|PHLDB2_uc003dyi.2_Intron	NM_001134438	NP_001127910			pleckstrin homology-like domain, family B,							cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6																		---	---	---	---
ATG3	64422	broad.mit.edu	37	3	112277267	112277267	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:112277267delA	uc003dzd.2	-						ATG3_uc003dzc.2_Intron|ATG3_uc010hqe.2_Intron	NM_022488	NP_071933			Apg3p						autophagic vacuole assembly|mitochondrial fragmentation involved in apoptosis|protein targeting to membrane|protein ubiquitination	cytoplasmic ubiquitin ligase complex|cytosol	Atg12 ligase activity|Atg8 ligase activity|enzyme binding			ovary(3)	3																		---	---	---	---
CCDC80	151887	broad.mit.edu	37	3	112329034	112329034	+	Intron	DEL	A	-	-	rs146699705		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:112329034delA	uc003dzf.2	-						CCDC80_uc011bhv.1_Intron|CCDC80_uc003dzg.2_Intron|CCDC80_uc003dzh.1_Intron	NM_199512	NP_955806			steroid-sensitive protein 1 precursor											ovary(2)	2																		---	---	---	---
NAA50	80218	broad.mit.edu	37	3	113459588	113459588	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:113459588delT	uc003ean.1	-						NAA50_uc010hqm.1_5'Flank|NAA50_uc011bij.1_Intron	NM_025146	NP_079422			N-acetyltransferase 13						N-terminal protein amino acid acetylation	cytoplasm	N-acetyltransferase activity|protein binding				0																		---	---	---	---
KIAA1407	57577	broad.mit.edu	37	3	113699790	113699790	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:113699790delA	uc003eax.2	-						KIAA1407_uc011bin.1_Intron	NM_020817	NP_065868			hypothetical protein LOC57577											ovary(2)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	3	113822046	113822046	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:113822046delT								QTRTD1 (14780 upstream) : DRD3 (25511 downstream)																																			---	---	---	---
ZBTB20	26137	broad.mit.edu	37	3	114058003	114058003	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:114058003delG	uc003ebi.2	-	5	2255	c.2075delC	c.(2074-2076)CCTfs	p.P692fs	ZBTB20_uc003ebj.2_Frame_Shift_Del_p.P619fs|ZBTB20_uc010hqp.2_Frame_Shift_Del_p.P619fs|ZBTB20_uc003ebk.2_Frame_Shift_Del_p.P619fs|ZBTB20_uc003ebl.2_Frame_Shift_Del_p.P619fs|ZBTB20_uc003ebm.2_Frame_Shift_Del_p.P619fs|ZBTB20_uc003ebn.2_Frame_Shift_Del_p.P619fs	NM_015642	NP_056457	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20 isoform	692					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)														---	---	---	---
LRRC58	116064	broad.mit.edu	37	3	120054593	120054593	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:120054593delA	uc003edr.2	-							NM_001099678	NP_001093148			leucine rich repeat containing 58												0				GBM - Glioblastoma multiforme(114;0.147)														---	---	---	---
POLQ	10721	broad.mit.edu	37	3	121217164	121217164	+	Intron	DEL	A	-	-	rs76023468		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:121217164delA	uc003eee.3	-							NM_199420	NP_955452			DNA polymerase theta						DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)									DNA_polymerases_(catalytic_subunits)					---	---	---	---
FBXO40	51725	broad.mit.edu	37	3	121340411	121340412	+	Frame_Shift_Ins	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:121340411_121340412insT	uc003eeg.2	+	3	345_346	c.135_136insT	c.(133-138)ACCTTCfs	p.T45fs		NM_016298	NP_057382	Q9UH90	FBX40_HUMAN	F-box protein 40	45_46					muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(114;0.189)														---	---	---	---
IQCB1	9657	broad.mit.edu	37	3	121518237	121518237	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:121518237delA	uc010hre.1	-						IQCB1_uc003eek.2_Intron|IQCB1_uc010hrf.1_Intron	NM_001023570	NP_001018864			IQ motif containing B1 isoform a						cilium assembly|maintenance of organ identity|photoreceptor cell maintenance	centrosome|photoreceptor connecting cilium	calmodulin binding				0				GBM - Glioblastoma multiforme(114;0.0983)														---	---	---	---
CD86	942	broad.mit.edu	37	3	121825017	121825017	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:121825017delT	uc003eet.2	+						CD86_uc011bjo.1_Intron|CD86_uc011bjp.1_Intron|CD86_uc003eeu.2_Intron	NM_175862	NP_787058			CD86 antigen isoform 1						interspecies interaction between organisms|positive regulation of cell proliferation|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of lymphotoxin A biosynthetic process|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation		coreceptor activity|protein binding			pancreas(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.156)	Abatacept(DB01281)													---	---	---	---
KPNA1	3836	broad.mit.edu	37	3	122180188	122180188	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:122180188delA	uc003efd.1	-						KPNA1_uc003efb.1_5'Flank|KPNA1_uc003efc.1_5'Flank|KPNA1_uc011bjr.1_Intron|KPNA1_uc010hrh.2_Intron|KPNA1_uc003efe.2_Intron	NM_002264	NP_002255			karyopherin alpha 1						DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|regulation of DNA recombination|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein binding|protein transporter activity				0				GBM - Glioblastoma multiforme(114;0.0898)														---	---	---	---
SLC41A3	54946	broad.mit.edu	37	3	125741581	125741581	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:125741581delC	uc003eij.2	-						SLC41A3_uc003eii.2_Intron|SLC41A3_uc003eil.2_Intron|SLC41A3_uc003eik.2_Intron|SLC41A3_uc011bkh.1_Intron|SLC41A3_uc010hsd.1_Intron	NM_001008485	NP_001008485			solute carrier family 41, member 3 isoform 1							integral to membrane|plasma membrane	cation transmembrane transporter activity				0				GBM - Glioblastoma multiforme(114;0.167)														---	---	---	---
GATA2	2624	broad.mit.edu	37	3	128202631	128202631	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:128202631delT	uc003ekm.3	-						GATA2_uc003ekn.3_Intron|GATA2_uc003eko.2_Intron	NM_001145661	NP_001139133			GATA binding protein 2 isoform 1						blood coagulation|negative regulation of fat cell differentiation|negative regulation of fat cell proliferation|negative regulation of neural precursor cell proliferation|negative regulation of Notch signaling pathway|phagocytosis|positive regulation of angiogenesis|positive regulation of phagocytosis|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	C2H2 zinc finger domain binding|chromatin binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(13)|lung(1)|skin(1)	15				GBM - Glioblastoma multiforme(114;0.173)				Mis		AML(CML blast transformation)								---	---	---	---
RAB43	339122	broad.mit.edu	37	3	128849575	128849575	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:128849575delA	uc003elo.1	-						ISY1_uc010hsz.1_Intron|ISY1_uc003elp.1_Intron|ISY1_uc010hta.1_Intron	NM_020701	NP_065752			ISY1 splicing factor homolog						protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			lung(1)	1																		---	---	---	---
RAB43	339122	broad.mit.edu	37	3	128875524	128875524	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:128875524delA	uc003elo.1	-						ISY1_uc010hsz.1_Intron|ISY1_uc003elp.1_Intron|ISY1_uc010hta.1_Intron	NM_020701	NP_065752			ISY1 splicing factor homolog						protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			lung(1)	1																		---	---	---	---
COPG	22820	broad.mit.edu	37	3	128974023	128974023	+	Intron	DEL	T	-	-	rs63166061		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:128974023delT	uc003els.2	+						COPG_uc010htb.2_Intron	NM_016128	NP_057212			coatomer protein complex, subunit gamma 1						COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(3)|breast(1)	4																		---	---	---	---
Unknown	0	broad.mit.edu	37	3	132106524	132106524	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:132106524delA								ACPP (19380 upstream) : DNAJC13 (30029 downstream)																																			---	---	---	---
DNAJC13	23317	broad.mit.edu	37	3	132193668	132193675	+	Intron	DEL	CCCTTTTT	-	-	rs35380727		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:132193668_132193675delCCCTTTTT	uc003eor.2	+							NM_015268	NP_056083			DnaJ (Hsp40) homolog, subfamily C, member 13								heat shock protein binding			ovary(1)|breast(1)	2																		---	---	---	---
DNAJC13	23317	broad.mit.edu	37	3	132199190	132199190	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:132199190delA	uc003eor.2	+							NM_015268	NP_056083			DnaJ (Hsp40) homolog, subfamily C, member 13								heat shock protein binding			ovary(1)|breast(1)	2																		---	---	---	---
UBA5	79876	broad.mit.edu	37	3	132390860	132390860	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:132390860delT	uc003epa.3	+						NPHP3_uc003eoz.1_Intron|UBA5_uc010htr.2_Intron|UBA5_uc010htt.2_Intron|UBA5_uc003epb.3_Intron	NM_024818	NP_079094			ubiquitin-activating enzyme 5 isoform 1						protein ufmylation	aggresome|cytoplasm|cytoplasm|nucleus	ATP binding|cofactor binding|metal ion binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding|UFM1 activating enzyme activity			kidney(1)	1																		---	---	---	---
TOPBP1	11073	broad.mit.edu	37	3	133361872	133361873	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:133361872_133361873delTT	uc003eps.2	-							NM_007027	NP_008958			topoisomerase (DNA) II binding protein 1						DNA repair|response to ionizing radiation	microtubule organizing center|PML body|spindle pole	DNA binding|protein C-terminus binding			ovary(2)|kidney(2)|skin(1)|lung(1)|pancreas(1)	7													Other_conserved_DNA_damage_response_genes					---	---	---	---
CEP63	80254	broad.mit.edu	37	3	134278353	134278353	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:134278353delT	uc003eqo.1	+						CEP63_uc003eql.1_Intron|CEP63_uc003eqm.2_Intron|CEP63_uc003eqn.1_Intron	NM_025180	NP_079456			centrosomal protein 63 isoform a						cell division|DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitosis|signal transduction in response to DNA damage|spindle assembly	centrosome|cytosol|spindle pole	protein binding			ovary(1)	1																		---	---	---	---
MSL2	55167	broad.mit.edu	37	3	135871342	135871344	+	In_Frame_Del	DEL	AGA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:135871342_135871344delAGA	uc003eqx.1	-	2	1112_1114	c.379_381delTCT	c.(379-381)TCTdel	p.S127del	MSL2_uc011bmb.1_In_Frame_Del_p.S53del	NM_018133	NP_060603	Q9HCI7	MSL2_HUMAN	ring finger protein 184 isoform 1	127					histone H4-K16 acetylation	MSL complex	zinc ion binding			central_nervous_system(1)	1																		---	---	---	---
MSL2	55167	broad.mit.edu	37	3	135899659	135899662	+	Intron	DEL	GGAA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:135899659_135899662delGGAA	uc003eqx.1	-						MSL2_uc011bmb.1_Intron	NM_018133	NP_060603			ring finger protein 184 isoform 1						histone H4-K16 acetylation	MSL complex	zinc ion binding			central_nervous_system(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	3	137009715	137009716	+	IGR	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:137009715_137009716insT								IL20RB (279795 upstream) : SOX14 (473863 downstream)																																			---	---	---	---
ARMC8	25852	broad.mit.edu	37	3	137988856	137988856	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:137988856delT	uc003esa.1	+						TXNDC6_uc003esd.1_Intron|TXNDC6_uc010huf.1_Intron|TXNDC6_uc003ese.1_Intron|ARMC8_uc011bmf.1_Intron|ARMC8_uc011bmg.1_Intron|ARMC8_uc011bmh.1_Intron|ARMC8_uc003esb.1_Intron|ARMC8_uc003esc.1_Intron|ARMC8_uc003esf.1_Intron	NM_015396	NP_056211			armadillo repeat containing 8 isoform 2								binding				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	3	141189385	141189392	+	IGR	DEL	TTTTTTTT	-	-	rs71629505		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:141189385_141189392delTTTTTTTT								ZBTB38 (20760 upstream) : RASA2 (16534 downstream)																																			---	---	---	---
TFDP2	7029	broad.mit.edu	37	3	141697193	141697193	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:141697193delA	uc003eun.3	-						TFDP2_uc003euk.3_Intron|TFDP2_uc010hur.2_Intron|TFDP2_uc003eul.3_Intron|TFDP2_uc011bnf.1_Intron|TFDP2_uc011bng.1_Intron|TFDP2_uc003eum.3_Intron	NM_006286	NP_006277			transcription factor Dp-2 (E2F dimerization						cell cycle	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|transcription factor binding			kidney(1)	1																		---	---	---	---
ATR	545	broad.mit.edu	37	3	142217557	142217557	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:142217557delT	uc003eux.3	-	32	5562	c.5440delA	c.(5440-5442)AGAfs	p.R1814fs		NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	1814	FAT.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20													Other_conserved_DNA_damage_response_genes					---	---	---	---
ATR	545	broad.mit.edu	37	3	142223906	142223907	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:142223906_142223907insA	uc003eux.3	-							NM_001184	NP_001175			ataxia telangiectasia and Rad3 related protein						cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20													Other_conserved_DNA_damage_response_genes					---	---	---	---
ATR	545	broad.mit.edu	37	3	142279407	142279407	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:142279407delT	uc003eux.3	-							NM_001184	NP_001175			ataxia telangiectasia and Rad3 related protein						cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20													Other_conserved_DNA_damage_response_genes					---	---	---	---
SLC9A9	285195	broad.mit.edu	37	3	143513734	143513734	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:143513734delA	uc003evn.2	-						SLC9A9_uc011bnk.1_Intron	NM_173653	NP_775924			solute carrier family 9 (sodium/hydrogen						regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			ovary(2)|skin(1)	3																		---	---	---	---
PLSCR5	389158	broad.mit.edu	37	3	146309456	146309456	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:146309456delA	uc003ewb.2	-						PLSCR5_uc010hvb.2_Intron|PLSCR5_uc010hvc.2_Intron	NM_001085420	NP_001078889			phospholipid scramblase family, member 5												0																		---	---	---	---
HLTF	6596	broad.mit.edu	37	3	148767867	148767867	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:148767867delA	uc003ewq.1	-						HLTF_uc003ewr.1_Intron|HLTF_uc003ews.1_Intron|HLTF_uc010hve.1_Intron	NM_139048	NP_620636			helicase-like transcription factor						chromatin modification|transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)															---	---	---	---
CP	1356	broad.mit.edu	37	3	148916129	148916130	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:148916129_148916130delTT	uc003ewy.3	-						CP_uc011bnr.1_Intron|CP_uc003ewx.3_Intron|CP_uc003ewz.2_Intron|CP_uc010hvf.1_Intron	NM_000096	NP_000087			ceruloplasmin precursor						cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			ovary(1)	1		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)													---	---	---	---
CP	1356	broad.mit.edu	37	3	148923939	148923939	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:148923939delT	uc003ewy.3	-						CP_uc011bnr.1_Intron|CP_uc003ewx.3_Intron|CP_uc003ewz.2_Intron|CP_uc010hvf.1_Intron	NM_000096	NP_000087			ceruloplasmin precursor						cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			ovary(1)	1		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)													---	---	---	---
EIF2A	83939	broad.mit.edu	37	3	150282062	150282063	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:150282062_150282063delTT	uc003eya.2	+						SERP1_uc003exz.2_Intron|EIF2A_uc003eyb.2_Intron|EIF2A_uc003eyc.2_Intron|EIF2A_uc011bnv.1_Intron|EIF2A_uc011bnw.1_Intron|EIF2A_uc003eyd.2_Intron	NM_032025	NP_114414			eukaryotic translation initiation factor 2A						regulation of translation|ribosome assembly	eukaryotic translation initiation factor 2 complex	ribosome binding|translation initiation factor activity|tRNA binding				0		Melanoma(1037;0.0575)	LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)															---	---	---	---
CLRN1	7401	broad.mit.edu	37	3	150690101	150690102	+	Intron	DEL	AG	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:150690101_150690102delAG	uc003eyk.1	-						CLRN1OS_uc011bny.1_Intron|CLRN1OS_uc003eyl.2_5'Flank	NM_174878	NP_777367			clarin 1 isoform a						equilibrioception|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	integral to membrane					0			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)															---	---	---	---
P2RY12	64805	broad.mit.edu	37	3	151055936	151055936	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:151055936delT	uc003eyw.1	-	2	914	c.698delA	c.(697-699)AAGfs	p.K233fs	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron|P2RY12_uc011boa.1_3'UTR|P2RY12_uc003eyx.1_Frame_Shift_Del_p.K233fs	NM_176876	NP_795345	Q9H244	P2Y12_HUMAN	purinergic receptor P2Y12	233	Cytoplasmic (Potential).				platelet activation	integral to membrane|plasma membrane	guanyl-nucleotide exchange factor activity			skin(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)		Clopidogrel(DB00758)|Epoprostenol(DB01240)|Ticlopidine(DB00208)|Treprostinil(DB00374)													---	---	---	---
MED12L	116931	broad.mit.edu	37	3	151072833	151072833	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:151072833delA	uc003eyp.2	+						MED12L_uc011bnz.1_Intron|P2RY12_uc011boa.1_Intron|P2RY12_uc003eyx.1_Intron|MED12L_uc003eyy.1_5'Flank	NM_053002	NP_443728			mediator of RNA polymerase II transcription,						regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)															---	---	---	---
C3orf79	152118	broad.mit.edu	37	3	153203781	153203781	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:153203781delT	uc003ezt.2	+							NM_001101337	NP_001094807			chromosome 3 open reading frame 79												0																		---	---	---	---
DHX36	170506	broad.mit.edu	37	3	154010602	154010602	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:154010602delT	uc003ezy.3	-						DHX36_uc010hvq.2_Intron|DHX36_uc003ezz.3_Intron	NM_020865	NP_065916			DEAH (Asp-Glu-Ala-His) box polypeptide 36							cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)															---	---	---	---
MME	4311	broad.mit.edu	37	3	154834153	154834153	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:154834153delT	uc010hvr.1	+						MME_uc003fab.1_Intron|MME_uc003fac.1_Intron|MME_uc003fad.1_Intron|MME_uc003fae.1_Intron	NM_007289	NP_009220			membrane metallo-endopeptidase						cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)													---	---	---	---
MME	4311	broad.mit.edu	37	3	154884658	154884659	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:154884658_154884659insA	uc010hvr.1	+						MME_uc003fab.1_Intron|MME_uc003fac.1_Intron|MME_uc003fad.1_Intron|MME_uc003fae.1_Intron	NM_007289	NP_009220			membrane metallo-endopeptidase						cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)													---	---	---	---
KCNAB1	7881	broad.mit.edu	37	3	156177758	156177758	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:156177758delA	uc003far.2	+						KCNAB1_uc011bon.1_Intron|KCNAB1_uc003fas.2_Intron|KCNAB1_uc003fat.2_Intron|KCNAB1_uc010hvt.1_Intron|KCNAB1_uc011boo.1_Intron	NM_172160	NP_751892			potassium voltage-gated channel, shaker-related							cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			ovary(3)|skin(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)															---	---	---	---
GFM1	85476	broad.mit.edu	37	3	158371355	158371355	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:158371355delT	uc003fce.2	+						GFM1_uc003fcd.2_Intron|GFM1_uc003fcf.2_Intron|GFM1_uc003fcg.2_Intron	NM_024996	NP_079272			G elongation factor, mitochondrial 1 precursor						mitochondrial translational elongation	mitochondrion	GTP binding|GTPase activity|translation elongation factor activity			ovary(3)|central_nervous_system(1)	4			Lung(72;0.00309)|LUSC - Lung squamous cell carcinoma(72;0.0043)															---	---	---	---
IFT80	57560	broad.mit.edu	37	3	159996858	159996858	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:159996858delA	uc011boy.1	-						IFT80_uc003fda.2_Intron|IFT80_uc003fdb.1_Intron|IFT80_uc003fdd.1_Intron|IFT80_uc003fde.1_Intron	NM_020800	NP_065851			WD repeat domain 56							cilium axoneme|microtubule basal body				ovary(1)	1			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)															---	---	---	---
SMC4	10051	broad.mit.edu	37	3	160138724	160138725	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:160138724_160138725delTT	uc003fdh.2	+						IFT80_uc003fda.2_Intron|SMC4_uc010hwc.1_Intron|SMC4_uc003fdi.2_Intron|SMC4_uc003fdj.2_Intron|SMC4_uc010hwd.2_Intron|SMC4_uc003fdl.2_Intron	NM_001002800	NP_001002800			SMC4 structural maintenance of chromosomes						cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			ovary(1)|breast(1)	2			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)															---	---	---	---
SMC4	10051	broad.mit.edu	37	3	160141148	160141148	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:160141148delT	uc003fdh.2	+						IFT80_uc003fda.2_Intron|SMC4_uc010hwc.1_Intron|SMC4_uc003fdi.2_Intron|SMC4_uc003fdj.2_Intron|SMC4_uc010hwd.2_Intron|SMC4_uc003fdl.2_Intron	NM_001002800	NP_001002800			SMC4 structural maintenance of chromosomes						cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			ovary(1)|breast(1)	2			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)															---	---	---	---
NMD3	51068	broad.mit.edu	37	3	160942656	160942656	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:160942656delA	uc003feb.1	+						NMD3_uc003fec.2_Intron|NMD3_uc003fed.1_Intron	NM_015938	NP_057022			NMD3 homolog						protein transport	cytoplasm|nucleolus|nucleoplasm				ovary(1)	1			Lung(72;0.00111)|LUSC - Lung squamous cell carcinoma(72;0.00156)															---	---	---	---
NMD3	51068	broad.mit.edu	37	3	160964183	160964183	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:160964183delT	uc003feb.1	+	12	1196	c.1077delT	c.(1075-1077)TATfs	p.Y359fs	NMD3_uc003fec.2_Frame_Shift_Del_p.Y359fs|NMD3_uc003fed.1_Frame_Shift_Del_p.Y359fs|NMD3_uc010hwh.2_Frame_Shift_Del_p.Y179fs	NM_015938	NP_057022	Q96D46	NMD3_HUMAN	NMD3 homolog	359					protein transport	cytoplasm|nucleolus|nucleoplasm				ovary(1)	1			Lung(72;0.00111)|LUSC - Lung squamous cell carcinoma(72;0.00156)															---	---	---	---
Unknown	0	broad.mit.edu	37	3	166579565	166579565	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:166579565delT								None (None upstream) : ZBBX (378516 downstream)																																			---	---	---	---
WDR49	151790	broad.mit.edu	37	3	167223286	167223287	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:167223286_167223287insA	uc003fev.1	-						WDR49_uc003feu.1_Intron|WDR49_uc011bpd.1_Intron|WDR49_uc003few.1_Intron	NM_178824	NP_849146			WD repeat domain 49											large_intestine(1)|ovary(1)|skin(1)	3																		---	---	---	---
WDR49	151790	broad.mit.edu	37	3	167249103	167249103	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:167249103delA	uc003fev.1	-						WDR49_uc003feu.1_Intron|WDR49_uc011bpd.1_Intron|WDR49_uc003few.1_Intron	NM_178824	NP_849146			WD repeat domain 49											large_intestine(1)|ovary(1)|skin(1)	3																		---	---	---	---
WDR49	151790	broad.mit.edu	37	3	167320082	167320082	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:167320082delA	uc003fev.1	-						WDR49_uc011bpd.1_Intron|WDR49_uc003few.1_Intron	NM_178824	NP_849146			WD repeat domain 49											large_intestine(1)|ovary(1)|skin(1)	3																		---	---	---	---
MECOM	2122	broad.mit.edu	37	3	169201795	169201795	+	Intron	DEL	T	-	-	rs78338445		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:169201795delT	uc011bpj.1	-						MECOM_uc011bpk.1_Intron|MECOM_uc010hwn.2_Intron|MECOM_uc011bpl.1_Intron	NM_004991	NP_004982			MDS1 and EVI1 complex locus isoform c						apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14																		---	---	---	---
LRRC34	151827	broad.mit.edu	37	3	169522094	169522094	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:169522094delT	uc003ffx.2	-						LRRC34_uc003ffy.2_Intron|LRRC34_uc011bpn.1_Intron|LRRC34_uc003ffz.2_Intron|LRRC34_uc003fga.3_Intron	NM_153353	NP_699184			leucine rich repeat containing 34												0	all_cancers(22;4.12e-22)|all_epithelial(15;7.54e-27)|all_lung(20;1.63e-16)|Lung NSC(18;6.92e-16)|Ovarian(172;0.000223)|Breast(254;0.197)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00676)															---	---	---	---
PHC3	80012	broad.mit.edu	37	3	169847482	169847482	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:169847482delA	uc010hws.1	-						PHC3_uc003fgl.2_Intron|PHC3_uc011bpq.1_Intron|PHC3_uc011bpr.1_Intron	NM_024947	NP_079223			polyhomeotic like 3						multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_cancers(22;2.67e-22)|all_epithelial(15;4.73e-27)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)															---	---	---	---
NDUFB5	4711	broad.mit.edu	37	3	179334935	179334936	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:179334935_179334936insT	uc003fkc.2	+						NDUFB5_uc003fkd.2_Intron|NDUFB5_uc003fke.2_Intron	NM_002492	NP_002483			NADH dehydrogenase (ubiquinone) 1 beta						mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			skin(1)	1	all_cancers(143;9.62e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)|BRCA - Breast invasive adenocarcinoma(182;0.18)		NADH(DB00157)													---	---	---	---
CCDC39	339829	broad.mit.edu	37	3	180334046	180334047	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:180334046_180334047delTT	uc010hxe.2	-						CCDC39_uc003fkn.2_Intron|TTC14_uc003fkm.2_Intron	NM_181426	NP_852091			coiled-coil domain containing 39						axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				ovary(4)	4	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)															---	---	---	---
Unknown	0	broad.mit.edu	37	3	180863907	180863908	+	IGR	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:180863907_180863908delAA								DNAJC19 (156377 upstream) : SOX2OT (417601 downstream)																																			---	---	---	---
PARL	55486	broad.mit.edu	37	3	183584703	183584703	+	Intron	DEL	T	-	-	rs79270886		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:183584703delT	uc003fmd.2	-						PARL_uc003fme.2_Intron	NM_018622	NP_061092			presenilin associated, rhomboid-like isoform 1						proteolysis	integral to membrane|mitochondrial inner membrane|nucleus	serine-type endopeptidase activity				0	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.21e-41)|Epithelial(37;1.34e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)															---	---	---	---
PARL	55486	broad.mit.edu	37	3	183585488	183585490	+	Intron	DEL	AAA	-	-	rs111387397		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:183585488_183585490delAAA	uc003fmd.2	-						PARL_uc003fme.2_Intron	NM_018622	NP_061092			presenilin associated, rhomboid-like isoform 1						proteolysis	integral to membrane|mitochondrial inner membrane|nucleus	serine-type endopeptidase activity				0	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.21e-41)|Epithelial(37;1.34e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)															---	---	---	---
EIF4G1	1981	broad.mit.edu	37	3	184042258	184042259	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:184042258_184042259insT	uc003fnp.2	+						EIF4G1_uc003fno.1_Intron|EIF4G1_uc010hxw.1_Intron|EIF4G1_uc003fnt.2_Intron|EIF4G1_uc003fnq.2_Intron|EIF4G1_uc003fnr.2_Intron|EIF4G1_uc010hxx.2_Intron|EIF4G1_uc003fns.2_Intron|EIF4G1_uc010hxy.2_Intron|EIF4G1_uc003fnv.3_Intron|EIF4G1_uc003fnu.3_Intron|EIF4G1_uc003fnw.2_Intron|EIF4G1_uc003fnx.2_Intron|EIF4G1_uc003fny.3_Intron|SNORD66_uc003fnz.2_5'Flank	NM_198241	NP_937884			eukaryotic translation initiation factor 4						insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)															---	---	---	---
LEPREL1	55214	broad.mit.edu	37	3	189700671	189700671	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:189700671delT	uc011bsk.1	-						LEPREL1_uc003fsg.2_Intron	NM_018192	NP_060662			leprecan-like 1 isoform a						collagen metabolic process|negative regulation of cell proliferation|peptidyl-proline hydroxylation	basement membrane|endoplasmic reticulum|Golgi apparatus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			breast(3)|ovary(1)	4	all_cancers(143;4.01e-10)|Ovarian(172;0.0925)		Lung(62;4.35e-05)	GBM - Glioblastoma multiforme(93;0.02)	L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)													---	---	---	---
OPA1	4976	broad.mit.edu	37	3	193364840	193364840	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:193364840delT	uc003ftm.2	+						OPA1_uc003ftg.2_Intron|OPA1_uc003fth.2_Intron|OPA1_uc003fti.2_Intron|OPA1_uc003ftj.2_Intron|OPA1_uc003ftk.2_Intron|OPA1_uc003ftl.2_Intron|OPA1_uc003ftn.2_Intron	NM_015560	NP_056375			optic atrophy 1 isoform 1						apoptosis|axon transport of mitochondrion|inner mitochondrial membrane organization|mitochondrial fission|mitochondrial fusion|positive regulation of anti-apoptosis|response to stimulus|visual perception	dendrite|integral to membrane|mitochondrial crista|mitochondrial intermembrane space|mitochondrial outer membrane	GTP binding|GTPase activity|magnesium ion binding|protein binding				0	all_cancers(143;9.56e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;9.19e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000162)														---	---	---	---
ATP13A3	79572	broad.mit.edu	37	3	194167585	194167586	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:194167585_194167586insA	uc003fty.3	-						ATP13A3_uc003ftz.1_Intron	NM_024524	NP_078800			ATPase type 13A3						ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(1)	1	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)														---	---	---	---
ACAP2	23527	broad.mit.edu	37	3	195010024	195010024	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:195010024delA	uc003fun.3	-							NM_012287	NP_036419			centaurin, beta 2						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)	2																		---	---	---	---
ACAP2	23527	broad.mit.edu	37	3	195015362	195015362	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:195015362delT	uc003fun.3	-							NM_012287	NP_036419			centaurin, beta 2						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	3	195664074	195664075	+	IGR	INS	-	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:195664074_195664075insG								TNK2 (25258 upstream) : SDHAP1 (22717 downstream)																																			---	---	---	---
PCYT1A	5130	broad.mit.edu	37	3	195975231	195975231	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:195975231delT	uc003fwg.2	-						PCYT1A_uc003fwh.2_Intron	NM_005017	NP_005008			choline phosphate cytidylyltransferase 1 alpha							cytosol|soluble fraction	choline-phosphate cytidylyltransferase activity				0	all_cancers(143;1.19e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.28e-24)|all cancers(36;1.01e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00259)	Choline(DB00122)													---	---	---	---
UBXN7	26043	broad.mit.edu	37	3	196118944	196118944	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:196118944delA	uc003fwm.3	-						UBXN7_uc003fwn.3_Intron|UBXN7_uc010iae.2_Intron	NM_015562	NP_056377			UBX domain containing 7								protein binding			ovary(2)|pancreas(1)	3																		---	---	---	---
DLG1	1739	broad.mit.edu	37	3	196793772	196793772	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:196793772delA	uc003fxo.3	-						DLG1_uc011bub.1_Intron|DLG1_uc011buc.1_Intron|DLG1_uc011bud.1_Intron|DLG1_uc003fxn.3_Intron|DLG1_uc011bue.1_Intron|DLG1_uc010ial.2_Intron	NM_001098424	NP_001091894			discs, large homolog 1 isoform 1						actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			ovary(3)	3	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)														---	---	---	---
DLG1	1739	broad.mit.edu	37	3	196818055	196818055	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:196818055delA	uc003fxo.3	-						DLG1_uc011bub.1_Intron|DLG1_uc011buc.1_Intron|DLG1_uc011bud.1_Intron|DLG1_uc003fxn.3_Intron|DLG1_uc011bue.1_Intron|DLG1_uc010ial.2_Intron|DLG1_uc011buf.1_Intron|DLG1_uc003fxp.2_Intron|DLG1_uc010iam.1_Intron	NM_001098424	NP_001091894			discs, large homolog 1 isoform 1						actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			ovary(3)	3	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)														---	---	---	---
LRCH3	84859	broad.mit.edu	37	3	197577912	197577912	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:197577912delT	uc011bul.1	+						LRCH3_uc003fyj.1_Intron|LRCH3_uc011bum.1_Intron|LRCH3_uc011bun.1_Intron|LRCH3_uc003fyk.2_Intron	NM_032773	NP_116162			leucine-rich repeats and calponin homology (CH)							extracellular region				ovary(1)	1	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;4.82e-24)|all cancers(36;3.61e-22)|OV - Ovarian serous cystadenocarcinoma(49;7.08e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.119)														---	---	---	---
KIAA1530	57654	broad.mit.edu	37	4	1348691	1348692	+	Intron	INS	-	G	G	rs138445940	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:1348691_1348692insG	uc003gde.3	+							NM_020894	NP_065945			hypothetical protein LOC57654												0			OV - Ovarian serous cystadenocarcinoma(23;0.0138)															---	---	---	---
WHSC1	7468	broad.mit.edu	37	4	1959929	1959929	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:1959929delG	uc003gdz.3	+						WHSC1_uc003geb.3_Intron|WHSC1_uc003gec.3_Intron|WHSC1_uc003ged.3_Intron|WHSC1_uc003gee.3_Intron|WHSC1_uc003gef.3_Intron|WHSC1_uc003gei.3_Intron|WHSC1_uc011bvh.1_Intron|WHSC1_uc010icf.2_Intron	NM_001042424	NP_001035889			Wolf-Hirschhorn syndrome candidate 1 protein						anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)				T	IGH@	MM								---	---	---	---
POLN	353497	broad.mit.edu	37	4	2200403	2200403	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:2200403delT	uc003ger.2	-	4	756	c.756delA	c.(754-756)AAAfs	p.K252fs	POLN_uc010ich.1_5'UTR|POLN_uc011bvi.1_Frame_Shift_Del_p.K252fs	NM_181808	NP_861524	Q7Z5Q5	DPOLN_HUMAN	DNA-directed DNA polymerase nu	252					DNA repair|DNA replication	nucleus	DNA binding|DNA-directed DNA polymerase activity			kidney(2)|ovary(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(23;0.0955)										DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					---	---	---	---
POLN	353497	broad.mit.edu	37	4	2240173	2240173	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:2240173delA	uc011bvi.1	-						HAUS3_uc011bvj.1_Intron|HAUS3_uc003ges.1_Intron|HAUS3_uc003get.1_Intron	NM_181808	NP_861524			DNA-directed DNA polymerase nu						DNA repair|DNA replication	nucleus	DNA binding|DNA-directed DNA polymerase activity			kidney(2)|ovary(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(23;0.0955)										DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					---	---	---	---
FAM193A	8603	broad.mit.edu	37	4	2609678	2609679	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:2609678_2609679insT	uc010ick.2	+							NM_003704	NP_003695			hypothetical protein LOC8603											ovary(3)	3																		---	---	---	---
SH3BP2	6452	broad.mit.edu	37	4	2833721	2833722	+	Intron	DEL	TG	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:2833721_2833722delTG	uc003gfi.3	+						SH3BP2_uc011bvp.1_Intron|SH3BP2_uc003gfj.3_Intron|SH3BP2_uc003gfk.3_Intron|SH3BP2_uc003gfl.3_Intron|SH3BP2_uc003gfm.3_Intron	NM_001122681	NP_001116153			SH3-domain binding protein 2 isoform a						signal transduction		SH3 domain binding|SH3/SH2 adaptor activity			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.164)										Cherubism				---	---	---	---
GRK4	2868	broad.mit.edu	37	4	2965875	2965875	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:2965875delC	uc003ggn.1	+						GRK4_uc003ggo.1_Intron|GRK4_uc003ggp.1_Intron|GRK4_uc003ggq.1_Intron|NOP14_uc003ggj.1_5'Flank|NOP14_uc003ggk.3_5'Flank|NOP14_uc003ggl.2_5'Flank|NOP14_uc010icq.1_5'Flank|GRK4_uc003ggm.2_Intron	NM_182982	NP_892027			G protein-coupled receptor kinase 4 isoform							cell cortex	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			lung(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)														---	---	---	---
GRK4	2868	broad.mit.edu	37	4	2986251	2986251	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:2986251delA	uc003ggn.1	+	2	519	c.64delA	c.(64-66)AAAfs	p.K22fs	GRK4_uc003ggo.1_Frame_Shift_Del_p.K22fs|GRK4_uc003ggp.1_Intron|GRK4_uc003ggq.1_Intron	NM_182982	NP_892027	P32298	GRK4_HUMAN	G protein-coupled receptor kinase 4 isoform	22	N-terminal.					cell cortex	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			lung(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)														---	---	---	---
DOK7	285489	broad.mit.edu	37	4	3494970	3494970	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:3494970delC	uc003ghd.2	+	7	1327	c.1257delC	c.(1255-1257)AGCfs	p.S419fs	DOK7_uc003ghe.2_Frame_Shift_Del_p.S281fs|DOK7_uc003ghf.2_Frame_Shift_Del_p.A161fs|DOK7_uc003ghg.1_Frame_Shift_Del_p.S109fs	NM_173660	NP_775931	Q18PE1	DOK7_HUMAN	downstream of tyrosine kinase 7 isoform 1	419					positive regulation of protein tyrosine kinase activity	cell junction|synapse	insulin receptor binding|protein kinase binding			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)														---	---	---	---
Unknown	0	broad.mit.edu	37	4	5550718	5550721	+	IGR	DEL	TCCC	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:5550718_5550721delTCCC								C4orf6 (21193 upstream) : EVC2 (13433 downstream)																																			---	---	---	---
SH3TC1	54436	broad.mit.edu	37	4	8242814	8242814	+	3'UTR	DEL	T	-	-	rs67520179		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:8242814delT	uc003gkv.3	+	18					SH3TC1_uc003gkw.3_3'UTR|SH3TC1_uc003gkx.3_RNA|SH3TC1_uc003gky.2_RNA	NM_018986	NP_061859			SH3 domain and tetratricopeptide repeats 1								binding			large_intestine(2)|pancreas(1)	3																		---	---	---	---
Unknown	0	broad.mit.edu	37	4	12185516	12185516	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:12185516delA								HS3ST1 (754979 upstream) : None (None downstream)																																			---	---	---	---
FBXL5	26234	broad.mit.edu	37	4	15613834	15613834	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:15613834delA	uc003goc.1	-						FBXL5_uc010idw.1_Intron|FBXL5_uc003gob.1_Intron|FBXL5_uc010idx.1_Intron|FBXL5_uc003god.1_Intron|FBXL5_uc010idy.1_3'UTR	NM_012161	NP_036293			F-box and leucine-rich repeat protein 5 isoform						iron ion homeostasis|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|SCF ubiquitin ligase complex	iron ion binding|protein binding|ubiquitin-protein ligase activity				0																		---	---	---	---
PROM1	8842	broad.mit.edu	37	4	15981205	15981205	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:15981205delA	uc003goo.2	-						PROM1_uc003gor.2_Intron|PROM1_uc003gos.2_Intron|PROM1_uc003got.2_Intron|PROM1_uc003gou.2_Intron|PROM1_uc003gop.2_Intron|PROM1_uc003goq.3_Intron	NM_006017	NP_006008			prominin 1 isoform 1						camera-type eye photoreceptor cell differentiation|photoreceptor cell maintenance|retina layer formation	apical plasma membrane|cell surface|integral to plasma membrane|microvillus membrane|photoreceptor outer segment membrane|plasma membrane	beta-actinin binding|cadherin binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)|central_nervous_system(1)	7																		---	---	---	---
PROM1	8842	broad.mit.edu	37	4	15989190	15989191	+	Intron	DEL	TC	-	-	rs2191004		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:15989190_15989191delTC	uc003goo.2	-						PROM1_uc003gor.2_Intron|PROM1_uc003gos.2_Intron|PROM1_uc003got.2_Intron|PROM1_uc003gou.2_Intron|PROM1_uc003gop.2_Intron|PROM1_uc003goq.3_Intron	NM_006017	NP_006008			prominin 1 isoform 1						camera-type eye photoreceptor cell differentiation|photoreceptor cell maintenance|retina layer formation	apical plasma membrane|cell surface|integral to plasma membrane|microvillus membrane|photoreceptor outer segment membrane|plasma membrane	beta-actinin binding|cadherin binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)|central_nervous_system(1)	7																		---	---	---	---
PROM1	8842	broad.mit.edu	37	4	16034810	16034810	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:16034810delT	uc003goo.2	-						PROM1_uc003gor.2_Intron|PROM1_uc003gos.2_Intron|PROM1_uc003got.2_Intron|PROM1_uc003gou.2_Intron|PROM1_uc003gop.2_Intron|PROM1_uc003goq.3_Intron|PROM1_uc010iec.1_Intron	NM_006017	NP_006008			prominin 1 isoform 1						camera-type eye photoreceptor cell differentiation|photoreceptor cell maintenance|retina layer formation	apical plasma membrane|cell surface|integral to plasma membrane|microvillus membrane|photoreceptor outer segment membrane|plasma membrane	beta-actinin binding|cadherin binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)|central_nervous_system(1)	7																		---	---	---	---
TAPT1	202018	broad.mit.edu	37	4	16215379	16215379	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:16215379delA	uc010ied.1	-						TAPT1_uc011bxe.1_Intron|TAPT1_uc003gow.3_Intron	NM_153365	NP_699196			transmembrane anterior posterior transformation							integral to membrane	growth hormone-releasing hormone receptor activity				0																		---	---	---	---
MED28	80306	broad.mit.edu	37	4	17623198	17623198	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:17623198delT	uc003gpi.1	+						MED28_uc003gpj.2_Intron	NM_025205	NP_079481			mediator complex subunit 28						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|membrane|nucleus	actin binding				0																		---	---	---	---
SLIT2	9353	broad.mit.edu	37	4	20524026	20524026	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:20524026delT	uc003gpr.1	+						SLIT2_uc003gps.1_Intron	NM_004787	NP_004778			slit homolog 2 precursor						apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11																		---	---	---	---
SLIT2	9353	broad.mit.edu	37	4	20530546	20530546	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:20530546delT	uc003gpr.1	+						SLIT2_uc003gps.1_Intron	NM_004787	NP_004778			slit homolog 2 precursor						apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11																		---	---	---	---
PPARGC1A	10891	broad.mit.edu	37	4	23825732	23825732	+	Intron	DEL	T	-	-	rs56881226	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:23825732delT	uc003gqs.2	-						PPARGC1A_uc003gqt.2_Intron|PPARGC1A_uc011bxp.1_Intron|PPARGC1A_uc010ier.1_Intron	NM_013261	NP_037393			peroxisome proliferator-activated receptor						androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			ovary(2)|lung(2)|kidney(2)|skin(2)	8		Breast(46;0.0503)																---	---	---	---
ANAPC4	29945	broad.mit.edu	37	4	25404688	25404688	+	Intron	DEL	A	-	-	rs34334840		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:25404688delA	uc003gro.2	+						ANAPC4_uc003grp.2_Intron	NM_013367	NP_037499			anaphase-promoting complex subunit 4						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G2/M transition of mitotic cell cycle|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding|ubiquitin-protein ligase activity			ovary(2)|large_intestine(1)|pancreas(1)|skin(1)	5		Breast(46;0.0503)																---	---	---	---
ARAP2	116984	broad.mit.edu	37	4	36126599	36126599	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:36126599delA	uc003gsq.1	-							NM_015230	NP_056045			ArfGAP with RhoGAP domain, ankyrin repeat and PH						regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3																		---	---	---	---
PGM2	55276	broad.mit.edu	37	4	37863108	37863108	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:37863108delT	uc011byb.1	+						PGM2_uc011byc.1_Intron	NM_018290	NP_060760			phosphoglucomutase 2						glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity|phosphopentomutase activity			ovary(1)	1																		---	---	---	---
TBC1D1	23216	broad.mit.edu	37	4	38097780	38097780	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:38097780delA	uc003gtb.2	+						TBC1D1_uc011byd.1_Intron|TBC1D1_uc010ifd.2_Intron	NM_015173	NP_055988			TBC1 (tre-2/USP6, BUB2, cdc16) domain family,							nucleus	Rab GTPase activator activity			ovary(1)	1																		---	---	---	---
FAM114A1	92689	broad.mit.edu	37	4	38937442	38937442	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:38937442delT	uc003gtn.2	+						FAM114A1_uc011byh.1_Intron|FAM114A1_uc010ifi.2_Intron	NM_138389	NP_612398			hypothetical protein LOC92689							cytoplasm				ovary(1)	1																		---	---	---	---
RFC1	5981	broad.mit.edu	37	4	39304919	39304922	+	Intron	DEL	AAAA	-	-	rs74757070		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:39304919_39304922delAAAA	uc003gty.1	-						RFC1_uc003gtx.1_Intron	NM_002913	NP_002904			replication factor C large subunit						DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|telomere maintenance via telomerase|transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4																		---	---	---	---
PDS5A	23244	broad.mit.edu	37	4	39974662	39974662	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:39974662delT	uc003guv.3	-						PDS5A_uc010ifo.2_Intron|PDS5A_uc003guw.3_Intron	NM_001100399	NP_001093869			PDS5, regulator of cohesion maintenance, homolog						cell division|mitosis|negative regulation of DNA replication	chromatin|nucleus	identical protein binding				0																		---	---	---	---
SLC30A9	10463	broad.mit.edu	37	4	42072521	42072521	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:42072521delT	uc003gwl.2	+						SLC30A9_uc011byx.1_Intron	NM_006345	NP_006336			solute carrier family 30 (zinc transporter),						nucleotide-excision repair|zinc ion transport	cytoskeleton|integral to membrane|nucleus	cation transmembrane transporter activity|nucleotide binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)	3																		---	---	---	---
SLC30A9	10463	broad.mit.edu	37	4	42080153	42080153	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:42080153delT	uc003gwl.2	+						SLC30A9_uc011byx.1_Intron	NM_006345	NP_006336			solute carrier family 30 (zinc transporter),						nucleotide-excision repair|zinc ion transport	cytoskeleton|integral to membrane|nucleus	cation transmembrane transporter activity|nucleotide binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)	3																		---	---	---	---
GABRG1	2565	broad.mit.edu	37	4	46050388	46050391	+	Intron	DEL	GAAG	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:46050388_46050391delGAAG	uc003gxb.2	-							NM_173536	NP_775807			gamma-aminobutyric acid A receptor, gamma 1						gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)														---	---	---	---
GABRB1	2560	broad.mit.edu	37	4	47428212	47428212	+	3'UTR	DEL	A	-	-	rs111359296		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:47428212delA	uc003gxh.2	+	9					GABRB1_uc011bze.1_3'UTR	NM_000812	NP_000803			gamma-aminobutyric acid (GABA) A receptor, beta						synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)													---	---	---	---
ATP10D	57205	broad.mit.edu	37	4	47492948	47492948	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:47492948delT	uc003gxk.1	+						ATP10D_uc003gxj.3_Intron	NM_020453	NP_065186			ATPase, class V, type 10D						ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3																		---	---	---	---
SLAIN2	57606	broad.mit.edu	37	4	48371975	48371975	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:48371975delA	uc003gya.3	+	2	643	c.499delA	c.(499-501)AAAfs	p.K167fs		NM_020846	NP_065897	Q9P270	SLAI2_HUMAN	SLAIN motif family, member 2	167						centrosome					0																		---	---	---	---
FRYL	285527	broad.mit.edu	37	4	48625114	48625114	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:48625114delA	uc003gyh.1	-						FRYL_uc003gyk.2_Intron|FRYL_uc003gyl.1_Intron|FRYL_uc003gym.1_Intron	NM_015030	NP_055845			furry-like						regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1																		---	---	---	---
FRYL	285527	broad.mit.edu	37	4	48625212	48625213	+	Intron	DEL	AC	-	-	rs776579	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:48625212_48625213delAC	uc003gyh.1	-						FRYL_uc003gyk.2_Intron|FRYL_uc003gyl.1_Intron|FRYL_uc003gym.1_Intron	NM_015030	NP_055845			furry-like						regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	4	49099749	49099753	+	IGR	DEL	TCCGG	-	-	rs60947727		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:49099749_49099753delTCCGG								CWH43 (35656 upstream) : None (None downstream)																																			---	---	---	---
SPATA18	132671	broad.mit.edu	37	4	52945099	52945099	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:52945099delC	uc003gzl.2	+						SPATA18_uc010igl.1_Intron|SPATA18_uc011bzq.1_Intron|SPATA18_uc003gzk.1_Intron	NM_145263	NP_660306			spermatogenesis associated 18 homolog						mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			ovary(2)|skin(2)	4			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)															---	---	---	---
Unknown	0	broad.mit.edu	37	4	56179421	56179422	+	IGR	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:56179421_56179422delTT								KDR (187659 upstream) : SRD5A3 (32987 downstream)																																			---	---	---	---
SRD5A3	79644	broad.mit.edu	37	4	56217825	56217825	+	Intron	DEL	A	-	-	rs34820507		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:56217825delA	uc003hau.2	+							NM_024592	NP_078868			steroid 5 alpha-reductase 3						androgen biosynthetic process|dolichol metabolic process|dolichol-linked oligosaccharide biosynthetic process|polyprenol catabolic process	endoplasmic reticulum membrane|integral to membrane	3-oxo-5-alpha-steroid 4-dehydrogenase activity|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor				0	all_cancers(7;0.0308)|all_lung(4;0.00195)|Lung NSC(11;0.00431)|all_epithelial(27;0.0425)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.0179)															---	---	---	---
EXOC1	55763	broad.mit.edu	37	4	56759962	56759963	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:56759962_56759963insA	uc003hbe.1	+						EXOC1_uc003hbf.1_Intron|EXOC1_uc003hbg.1_Intron	NM_018261	NP_060731			exocyst complex component 1 isoform 1						exocytosis|protein transport	exocyst	protein binding			ovary(2)|skin(2)|lung(1)|central_nervous_system(1)	6	Glioma(25;0.08)|all_neural(26;0.101)																	---	---	---	---
CEP135	9662	broad.mit.edu	37	4	56884135	56884136	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:56884135_56884136delTT	uc003hbi.2	+						CEP135_uc003hbj.2_Intron	NM_025009	NP_079285			centrosome protein 4						centriole replication|centriole-centriole cohesion|G2/M transition of mitotic cell cycle	centriole|cytosol	protein C-terminus binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	Glioma(25;0.08)|all_neural(26;0.101)																	---	---	---	---
POLR2B	5431	broad.mit.edu	37	4	57891037	57891037	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:57891037delT	uc003hcl.1	+						POLR2B_uc011cae.1_Intron|POLR2B_uc011caf.1_Intron|POLR2B_uc003hcm.1_Intron	NM_000938	NP_000929			DNA directed RNA polymerase II polypeptide B						mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			ovary(2)	2	Glioma(25;0.08)|all_neural(26;0.181)																	---	---	---	---
EPHA5	2044	broad.mit.edu	37	4	66535417	66535417	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:66535417delG	uc003hcy.2	-	1	237	c.44delC	c.(43-45)CCAfs	p.P15fs	EPHA5_uc003hcx.2_5'Flank|EPHA5_uc003hcz.2_Frame_Shift_Del_p.P15fs|EPHA5_uc011cah.1_Frame_Shift_Del_p.P15fs|EPHA5_uc011cai.1_Frame_Shift_Del_p.P15fs|EPHA5_uc003hda.2_Frame_Shift_Del_p.P15fs|uc003hdb.2_5'Flank	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	15					cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24															TSP Lung(17;0.13)			---	---	---	---
CENPC1	1060	broad.mit.edu	37	4	68378093	68378093	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:68378093delA	uc003hdd.1	-						CENPC1_uc010ihj.1_Intron|CENPC1_uc010ihk.1_Intron|CENPC1_uc010ihm.1_Intron	NM_001812	NP_001803			centromere protein C 1						mitotic prometaphase	condensed chromosome kinetochore|condensed nuclear chromosome, centromeric region|cytosol	DNA binding			urinary_tract(1)|lung(1)	2																		---	---	---	---
CENPC1	1060	broad.mit.edu	37	4	68384936	68384936	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:68384936delT	uc003hdd.1	-	6	799	c.616delA	c.(616-618)AGGfs	p.R206fs	CENPC1_uc010ihj.1_RNA|CENPC1_uc010ihk.1_RNA|CENPC1_uc010ihm.1_Frame_Shift_Del_p.R206fs	NM_001812	NP_001803	Q03188	CENPC_HUMAN	centromere protein C 1	206					mitotic prometaphase	condensed chromosome kinetochore|condensed nuclear chromosome, centromeric region|cytosol	DNA binding			urinary_tract(1)|lung(1)	2																		---	---	---	---
STAP1	26228	broad.mit.edu	37	4	68456664	68456664	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:68456664delA	uc003hde.3	+	7	804	c.722delA	c.(721-723)GAAfs	p.E241fs	STAP1_uc003hdf.2_Frame_Shift_Del_p.E241fs	NM_012108	NP_036240	Q9ULZ2	STAP1_HUMAN	signal transducing adaptor family member 1	241	SH2.				cellular membrane fusion|intracellular protein transport	cytoplasm					0																		---	---	---	---
TMPRSS11F	389208	broad.mit.edu	37	4	68929077	68929077	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:68929077delT	uc003hdt.1	-						LOC550112_uc003hdl.3_Intron|uc011cak.1_Intron|SYT14L_uc010ihn.2_5'Flank	NM_207407	NP_997290			transmembrane protease, serine 11F						proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	4	69344551	69344552	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:69344551_69344552insT	uc003hdz.3	+							NM_014058	NP_054777			transmembrane protease, serine 11E																														---	---	---	---
AMTN	401138	broad.mit.edu	37	4	71398133	71398133	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:71398133delT	uc003hfk.1	+						AMTN_uc010ihy.1_Intron	NM_212557	NP_997722			amelotin precursor						biomineral tissue development|cell adhesion|odontogenesis of dentine-containing tooth	basal lamina|cell-cell junction				large_intestine(1)|central_nervous_system(1)	2			Lung(101;0.235)															---	---	---	---
AMBN	258	broad.mit.edu	37	4	71458265	71458265	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:71458265delA	uc003hfl.2	+							NM_016519	NP_057603			ameloblastin precursor						bone mineralization|cell adhesion|cell proliferation|odontogenesis of dentine-containing tooth	proteinaceous extracellular matrix	growth factor activity|structural constituent of tooth enamel			ovary(3)|skin(1)	4			Lung(101;0.235)															---	---	---	---
ADAMTS3	9508	broad.mit.edu	37	4	73154639	73154640	+	Intron	DEL	AT	-	-	rs71992799		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:73154639_73154640delAT	uc003hgk.1	-							NM_014243	NP_055058			ADAM metallopeptidase with thrombospondin type 1						collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)															---	---	---	---
ADAMTS3	9508	broad.mit.edu	37	4	73174951	73174951	+	Intron	DEL	T	-	-	rs76753805		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:73174951delT	uc003hgk.1	-						ADAMTS3_uc003hgl.2_Intron	NM_014243	NP_055058			ADAM metallopeptidase with thrombospondin type 1						collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)															---	---	---	---
ADAMTS3	9508	broad.mit.edu	37	4	73177069	73177069	+	Intron	DEL	T	-	-	rs34684425		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:73177069delT	uc003hgk.1	-						ADAMTS3_uc003hgl.2_Intron	NM_014243	NP_055058			ADAM metallopeptidase with thrombospondin type 1						collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)															---	---	---	---
ADAMTS3	9508	broad.mit.edu	37	4	73185540	73185540	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:73185540delT	uc003hgk.1	-							NM_014243	NP_055058			ADAM metallopeptidase with thrombospondin type 1						collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)															---	---	---	---
ANKRD17	26057	broad.mit.edu	37	4	73958030	73958030	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:73958030delA	uc003hgp.2	-						ANKRD17_uc003hgo.2_Intron|ANKRD17_uc003hgq.2_Intron|ANKRD17_uc003hgr.2_Intron	NM_032217	NP_115593			ankyrin repeat domain protein 17 isoform a						interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)															---	---	---	---
EREG	2069	broad.mit.edu	37	4	75246761	75246762	+	Frame_Shift_Del	DEL	AA	-	-	rs145916659	byFrequency	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:75246761_75246762delAA	uc003hie.1	+	3	351_352	c.185_186delAA	c.(184-186)CAAfs	p.Q62fs	EREG_uc003hid.2_Frame_Shift_Del_p.Q56fs	NM_001432	NP_001423	O14944	EREG_HUMAN	epiregulin preproprotein	62	Extracellular (Potential).				angiogenesis|cell-cell signaling|cytokine-mediated signaling pathway|epidermal growth factor receptor signaling pathway|female meiosis|keratinocyte differentiation|keratinocyte proliferation|luteinizing hormone signaling pathway|mRNA transcription|negative regulation of epithelial cell proliferation|negative regulation of smooth muscle cell differentiation|negative regulation of transcription, DNA-dependent|oocyte maturation|organ morphogenesis|ovarian cumulus expansion|ovulation|positive regulation of cell division|positive regulation of cytokine production|positive regulation of DNA replication|positive regulation of epidermal growth factor receptor activity|positive regulation of fibroblast proliferation|positive regulation of innate immune response|positive regulation of interleukin-6 biosynthetic process|positive regulation of mitosis|positive regulation of phosphorylation|positive regulation of smooth muscle cell proliferation|primary follicle stage|wound healing	extracellular space|integral to plasma membrane	epidermal growth factor receptor binding|growth factor activity			breast(1)|skin(1)	2			Lung(101;0.196)															---	---	---	---
G3BP2	9908	broad.mit.edu	37	4	76581178	76581179	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:76581178_76581179delTT	uc003hir.2	-						G3BP2_uc003his.2_Intron|G3BP2_uc003hit.2_Intron	NM_012297	NP_036429			Ras-GTPase activating protein SH3 domain-binding						cytoplasmic sequestering of NF-kappaB|mRNA transport|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	GTPase activator activity|nucleotide binding|receptor signaling complex scaffold activity|RNA binding			breast(2)|central_nervous_system(1)	3			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)															---	---	---	---
USO1	8615	broad.mit.edu	37	4	76726517	76726518	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:76726517_76726518delTT	uc003hiu.2	+						USO1_uc003hiv.2_Intron|USO1_uc003hiw.2_Intron	NM_003715	NP_003706			USO1 homolog, vesicle docking protein						intracellular protein transport|vesicle fusion with Golgi apparatus	cytosol|Golgi membrane	protein binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)															---	---	---	---
PPEF2	5470	broad.mit.edu	37	4	76805590	76805592	+	Intron	DEL	AAT	-	-	rs60936146	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:76805590_76805592delAAT	uc003hix.2	-						PPEF2_uc003hiy.2_Intron|PPEF2_uc003hiz.1_Intron	NM_006239	NP_006230			serine/threonine protein phosphatase with						detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			ovary(2)|lung(1)|central_nervous_system(1)	4			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)															---	---	---	---
CXCL9	4283	broad.mit.edu	37	4	76926198	76926200	+	Intron	DEL	TTT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:76926198_76926200delTTT	uc003hjh.1	-							NM_002416	NP_002407			small inducible cytokine B9 precursor						cell-cell signaling|cellular defense response|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response	extracellular space	chemokine activity			ovary(1)	1			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)															---	---	---	---
CCNG2	901	broad.mit.edu	37	4	78080407	78080407	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:78080407delA	uc003hkq.3	+						CCNG2_uc003hkn.3_Intron|CCNG2_uc011ccc.1_Intron|CCNG2_uc003hkp.3_Intron	NM_004354	NP_004345			cyclin G2						cell cycle checkpoint|cell division|mitosis	cytoplasm				ovary(2)|lung(1)	3																		---	---	---	---
MRPL1	65008	broad.mit.edu	37	4	78804306	78804306	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:78804306delT	uc003hku.2	+						MRPL1_uc010iji.1_5'Flank	NM_020236	NP_064621			mitochondrial ribosomal protein L1 precursor								RNA binding				0																		---	---	---	---
FRAS1	80144	broad.mit.edu	37	4	79343327	79343327	+	Intron	DEL	T	-	-	rs72048849		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:79343327delT	uc003hlb.2	+						FRAS1_uc003hkw.2_Intron|FRAS1_uc010ijj.1_Intron	NM_025074	NP_079350			Fraser syndrome 1						cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5																		---	---	---	---
ANTXR2	118429	broad.mit.edu	37	4	80905990	80905990	+	Frame_Shift_Del	DEL	C	-	-	rs12647691	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:80905990delC	uc003hlz.3	-	13	1832	c.1069delG	c.(1069-1071)GCCfs	p.A357fs	ANTXR2_uc003hly.3_Frame_Shift_Del_p.A357fs|ANTXR2_uc003hlx.1_RNA|ANTXR2_uc010ijn.2_Frame_Shift_Del_p.A254fs	NM_001145794	NP_001139266	P58335	ANTR2_HUMAN	anthrax toxin receptor 2 isoform 2	357	Poly-Pro.|Cytoplasmic (Potential).					endoplasmic reticulum membrane|extracellular region|integral to membrane|plasma membrane	metal ion binding|protein binding|receptor activity			ovary(1)	1														Juvenile_Hyaline_Fibromatosis				---	---	---	---
C4orf22	255119	broad.mit.edu	37	4	81256796	81256796	+	5'Flank	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:81256796delG	uc003hmf.2	+						C4orf22_uc010ijp.2_5'Flank	NM_152770	NP_689983			hypothetical protein LOC255119											skin(2)	2																		---	---	---	---
BMP3	651	broad.mit.edu	37	4	81967644	81967644	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:81967644delA	uc003hmg.3	+	2	1389	c.1069delA	c.(1069-1071)AAAfs	p.K357fs		NM_001201	NP_001192	P12645	BMP3_HUMAN	bone morphogenetic protein 3 preproprotein	357					cartilage development|cell differentiation|cell-cell signaling|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			ovary(4)|central_nervous_system(1)	5																		---	---	---	---
PRKG2	5593	broad.mit.edu	37	4	82013505	82013505	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:82013505delA	uc003hmh.2	-						PRKG2_uc011ccf.1_Intron|PRKG2_uc011ccg.1_Intron|PRKG2_uc011cch.1_Intron	NM_006259	NP_006250			protein kinase, cGMP-dependent, type II						platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			breast(3)|central_nervous_system(2)|ovary(1)|large_intestine(1)	7																		---	---	---	---
ENOPH1	58478	broad.mit.edu	37	4	83381089	83381089	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:83381089delT	uc003hmv.2	+						ENOPH1_uc003hmw.2_Intron|ENOPH1_uc003hmx.2_Intron	NM_021204	NP_067027			enolase-phosphatase 1						L-methionine salvage from methylthioadenosine	cytoplasm|nucleus	2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity|2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity|acireductone synthase activity|magnesium ion binding|phosphoglycolate phosphatase activity				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	4	83493074	83493074	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:83493074delA								TMEM150C (9564 upstream) : C4orf11 (41193 downstream)																																			---	---	---	---
SEC31A	22872	broad.mit.edu	37	4	83778978	83778978	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:83778978delA	uc003hnf.2	-						SEC31A_uc003hne.2_Intron|SEC31A_uc011ccl.1_Intron|SEC31A_uc003hnl.2_Intron|SEC31A_uc003hng.2_Intron|SEC31A_uc003hnh.2_Intron|SEC31A_uc003hni.2_Intron|SEC31A_uc003hnj.2_Intron|SEC31A_uc011ccm.1_Intron|SEC31A_uc011ccn.1_Intron|SEC31A_uc003hnk.2_Intron|SEC31A_uc003hnm.2_Intron|SEC31A_uc003hnn.1_Intron	NM_001077207	NP_001070675			SEC31 homolog A isoform 1						COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/JAK2(4)|SEC31A/ALK(3)	haematopoietic_and_lymphoid_tissue(4)|soft_tissue(3)|breast(1)	8		Hepatocellular(203;0.114)																---	---	---	---
SEC31A	22872	broad.mit.edu	37	4	83784550	83784550	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:83784550delA	uc003hnf.2	-						SEC31A_uc003hne.2_Intron|SEC31A_uc011ccl.1_Intron|SEC31A_uc003hnl.2_Intron|SEC31A_uc003hng.2_Intron|SEC31A_uc003hnh.2_Intron|SEC31A_uc003hni.2_Intron|SEC31A_uc003hnj.2_Intron|SEC31A_uc011ccm.1_Intron|SEC31A_uc011ccn.1_Intron|SEC31A_uc003hnk.2_Intron|SEC31A_uc003hnm.2_Intron|SEC31A_uc003hnn.1_Intron|SEC31A_uc003hno.2_Intron	NM_001077207	NP_001070675			SEC31 homolog A isoform 1						COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/JAK2(4)|SEC31A/ALK(3)	haematopoietic_and_lymphoid_tissue(4)|soft_tissue(3)|breast(1)	8		Hepatocellular(203;0.114)																---	---	---	---
SEC31A	22872	broad.mit.edu	37	4	83785565	83785565	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:83785565delT	uc003hnf.2	-	11	1548	c.1384delA	c.(1384-1386)ATTfs	p.I462fs	SEC31A_uc003hne.2_Frame_Shift_Del_p.I234fs|SEC31A_uc011ccl.1_Frame_Shift_Del_p.I462fs|SEC31A_uc003hnl.2_Frame_Shift_Del_p.I462fs|SEC31A_uc003hng.2_Frame_Shift_Del_p.I462fs|SEC31A_uc003hnh.2_Frame_Shift_Del_p.I462fs|SEC31A_uc003hni.2_Frame_Shift_Del_p.I462fs|SEC31A_uc003hnj.2_Frame_Shift_Del_p.I462fs|SEC31A_uc011ccm.1_Frame_Shift_Del_p.I457fs|SEC31A_uc011ccn.1_Frame_Shift_Del_p.I462fs|SEC31A_uc003hnk.2_Frame_Shift_Del_p.I462fs|SEC31A_uc003hnm.2_Frame_Shift_Del_p.I462fs|SEC31A_uc003hnn.1_Frame_Shift_Del_p.I462fs|SEC31A_uc003hno.2_Frame_Shift_Del_p.I462fs	NM_001077207	NP_001070675	O94979	SC31A_HUMAN	SEC31 homolog A isoform 1	462	Interaction with SEC13.				COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/JAK2(4)|SEC31A/ALK(3)	haematopoietic_and_lymphoid_tissue(4)|soft_tissue(3)|breast(1)	8		Hepatocellular(203;0.114)																---	---	---	---
HPSE	10855	broad.mit.edu	37	4	84234175	84234176	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:84234175_84234176delAA	uc003hoj.3	-						HPSE_uc010ika.2_Intron|HPSE_uc011ccq.1_Intron|HPSE_uc011ccr.1_Intron|HPSE_uc011ccs.1_Intron|HPSE_uc011cct.1_Intron|HPSE_uc003hok.3_Intron	NM_001098540	NP_001092010			heparanase precursor						carbohydrate metabolic process|cell adhesion|proteoglycan metabolic process	extracellular region|lysosomal membrane|nucleus	beta-glucuronidase activity|cation binding			ovary(1)	1		Hepatocellular(203;0.114)		COAD - Colon adenocarcinoma(81;0.141)	Heparin(DB01109)													---	---	---	---
FAM175A	84142	broad.mit.edu	37	4	84390470	84390473	+	Intron	DEL	TTTT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:84390470_84390473delTTTT	uc003hou.2	-						FAM175A_uc003hot.2_5'UTR|FAM175A_uc003hov.2_Intron	NM_139076	NP_620775			coiled-coil domain containing 98						chromatin modification|double-strand break repair|G2/M transition DNA damage checkpoint|positive regulation of DNA repair|response to ionizing radiation	BRCA1-A complex	polyubiquitin binding			kidney(1)	1																		---	---	---	---
ARHGAP24	83478	broad.mit.edu	37	4	86491585	86491585	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:86491585delT	uc003hpk.2	+						ARHGAP24_uc003hpi.1_Intron|ARHGAP24_uc003hpj.2_Intron	NM_001025616	NP_001020787			Rho GTPase activating protein 24 isoform 1						angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell projection|cytoskeleton|cytosol|focal adhesion	GTPase activator activity|protein binding				0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000571)														---	---	---	---
Unknown	0	broad.mit.edu	37	4	87838466	87838467	+	IGR	DEL	AG	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:87838466_87838467delAG								C4orf36 (24891 upstream) : AFF1 (17696 downstream)																																			---	---	---	---
PKD2	5311	broad.mit.edu	37	4	88940482	88940482	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:88940482delA	uc003hre.2	+							NM_000297	NP_000288			polycystin 2							basal cortex|basal plasma membrane|endoplasmic reticulum|integral to membrane|lamellipodium|microtubule basal body	calcium ion binding|cytoskeletal protein binding|voltage-gated chloride channel activity|voltage-gated sodium channel activity			skin(1)	1		Hepatocellular(203;0.114)|Acute lymphoblastic leukemia(40;0.221)		OV - Ovarian serous cystadenocarcinoma(123;9.98e-10)|COAD - Colon adenocarcinoma(81;0.0237)														---	---	---	---
PKD2	5311	broad.mit.edu	37	4	88979251	88979251	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:88979251delT	uc003hre.2	+	9	2081	c.2015delT	c.(2014-2016)CTTfs	p.L672fs	PKD2_uc011cdf.1_Frame_Shift_Del_p.L90fs|PKD2_uc011cdg.1_Intron|PKD2_uc011cdh.1_Intron	NM_000297	NP_000288	Q13563	PKD2_HUMAN	polycystin 2	672	Helical; (Potential).					basal cortex|basal plasma membrane|endoplasmic reticulum|integral to membrane|lamellipodium|microtubule basal body	calcium ion binding|cytoskeletal protein binding|voltage-gated chloride channel activity|voltage-gated sodium channel activity			skin(1)	1		Hepatocellular(203;0.114)|Acute lymphoblastic leukemia(40;0.221)		OV - Ovarian serous cystadenocarcinoma(123;9.98e-10)|COAD - Colon adenocarcinoma(81;0.0237)														---	---	---	---
GPRIN3	285513	broad.mit.edu	37	4	90170454	90170454	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:90170454delG	uc003hsm.1	-	2	1327	c.808delC	c.(808-810)CTCfs	p.L270fs		NM_198281	NP_938022	Q6ZVF9	GRIN3_HUMAN	G protein-regulated inducer of neurite outgrowth	270										ovary(3)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)														---	---	---	---
ATOH1	474	broad.mit.edu	37	4	94750011	94750011	+	5'Flank	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:94750011delT	uc003hta.1	+							NM_005172	NP_005163			atonal homolog 1						transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity				0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.57e-07)														---	---	---	---
PDLIM5	10611	broad.mit.edu	37	4	95506692	95506692	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:95506692delT	uc003hti.2	+						PDLIM5_uc003htf.2_Intron|PDLIM5_uc003htg.2_Intron|PDLIM5_uc011cdx.1_Intron|PDLIM5_uc003hth.2_Intron|PDLIM5_uc003htj.2_Intron|PDLIM5_uc003htk.2_Intron|PDLIM5_uc011cdy.1_Intron|PDLIM5_uc003htl.2_Intron	NM_006457	NP_006448			PDZ and LIM domain 5 isoform a						regulation of dendritic spine morphogenesis|regulation of synaptogenesis	actin cytoskeleton|cell junction|cytosol|postsynaptic density|postsynaptic membrane|synaptosome	actin binding|actinin binding|protein kinase C binding|zinc ion binding			ovary(1)|skin(1)	2		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.84e-09)														---	---	---	---
PDLIM5	10611	broad.mit.edu	37	4	95508282	95508282	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:95508282delT	uc003hti.2	+						PDLIM5_uc003htf.2_3'UTR|PDLIM5_uc003htg.2_3'UTR|PDLIM5_uc011cdx.1_Intron|PDLIM5_uc003hth.2_Intron|PDLIM5_uc003htj.2_Intron|PDLIM5_uc003htk.2_Intron|PDLIM5_uc011cdy.1_Intron|PDLIM5_uc003htl.2_Intron	NM_006457	NP_006448			PDZ and LIM domain 5 isoform a						regulation of dendritic spine morphogenesis|regulation of synaptogenesis	actin cytoskeleton|cell junction|cytosol|postsynaptic density|postsynaptic membrane|synaptosome	actin binding|actinin binding|protein kinase C binding|zinc ion binding			ovary(1)|skin(1)	2		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.84e-09)														---	---	---	---
PDLIM5	10611	broad.mit.edu	37	4	95578859	95578859	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:95578859delT	uc003hti.2	+						PDLIM5_uc011cdx.1_Intron|PDLIM5_uc003hth.2_Intron|PDLIM5_uc003htj.2_Intron|PDLIM5_uc003htk.2_Intron|PDLIM5_uc011cdy.1_Intron|PDLIM5_uc003htl.2_Intron	NM_006457	NP_006448			PDZ and LIM domain 5 isoform a						regulation of dendritic spine morphogenesis|regulation of synaptogenesis	actin cytoskeleton|cell junction|cytosol|postsynaptic density|postsynaptic membrane|synaptosome	actin binding|actinin binding|protein kinase C binding|zinc ion binding			ovary(1)|skin(1)	2		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.84e-09)														---	---	---	---
RAP1GDS1	5910	broad.mit.edu	37	4	99182596	99182596	+	5'UTR	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:99182596delC	uc003htx.3	+	1					RAP1GDS1_uc003htu.2_5'UTR|RAP1GDS1_uc003htw.3_5'UTR|RAP1GDS1_uc003htv.3_5'UTR|RAP1GDS1_uc003htz.3_5'UTR|RAP1GDS1_uc003hty.3_5'UTR|RAP1GDS1_uc003hua.3_5'UTR	NM_001100427	NP_001093897			RAP1, GTP-GDP dissociation stimulator 1 isoform								binding|GTPase activator activity			ovary(1)|lung(1)|breast(1)	3				OV - Ovarian serous cystadenocarcinoma(123;2.9e-07)|LUSC - Lung squamous cell carcinoma(1;0.0253)|Lung(1;0.0576)				T	NUP98	T-ALL								---	---	---	---
TSPAN5	10098	broad.mit.edu	37	4	99408192	99408193	+	Intron	DEL	AG	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:99408192_99408193delAG	uc003hub.2	-						TSPAN5_uc011cdz.1_Intron	NM_005723	NP_005714			transmembrane 4 superfamily member 9							integral to membrane					0				OV - Ovarian serous cystadenocarcinoma(123;1.89e-07)														---	---	---	---
Unknown	0	broad.mit.edu	37	4	99772033	99772040	+	IGR	DEL	AGGAAGGA	-	-	rs11946627	by1000genomes;by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:99772033_99772040delAGGAAGGA								TSPAN5 (192306 upstream) : EIF4E (27567 downstream)																																			---	---	---	---
BANK1	55024	broad.mit.edu	37	4	102942661	102942661	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:102942661delT	uc003hvy.3	+						BANK1_uc003hvx.3_Intron|BANK1_uc010ill.2_Intron|BANK1_uc003hvz.3_Intron	NM_017935	NP_060405			B-cell scaffold protein with ankyrin repeats 1						B cell activation					ovary(2)|skin(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)														---	---	---	---
BANK1	55024	broad.mit.edu	37	4	102993735	102993735	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:102993735delA	uc003hvy.3	+						BANK1_uc003hvx.3_Intron|BANK1_uc010ill.2_Intron|BANK1_uc003hvz.3_Intron	NM_017935	NP_060405			B-cell scaffold protein with ankyrin repeats 1						B cell activation					ovary(2)|skin(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)														---	---	---	---
MANBA	4126	broad.mit.edu	37	4	103649712	103649712	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:103649712delA	uc003hwg.2	-						MANBA_uc011ces.1_Intron	NM_005908	NP_005899			mannosidase, beta A, lysosomal precursor						carbohydrate metabolic process|protein modification process	lysosome	beta-mannosidase activity|cation binding			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;4.44e-08)														---	---	---	---
CENPE	1062	broad.mit.edu	37	4	104055057	104055057	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:104055057delA	uc003hxb.1	-						CENPE_uc003hxc.1_Intron	NM_001813	NP_001804			centromere protein E						blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)														---	---	---	---
PPA2	27068	broad.mit.edu	37	4	106317313	106317313	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:106317313delA	uc003hxl.2	-						PPA2_uc003hxm.2_Intron|PPA2_uc003hxn.2_Intron|PPA2_uc003hxo.2_Intron|PPA2_uc003hxp.2_Intron|PPA2_uc003hxq.2_Intron|PPA2_uc003hxr.2_Intron	NM_176869	NP_789845			inorganic pyrophosphatase 2 isoform 1 precursor						diphosphate metabolic process|tRNA aminoacylation for protein translation	mitochondrial matrix	inorganic diphosphatase activity|magnesium ion binding			pancreas(1)	1		Myeloproliferative disorder(5;0.0255)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.03e-07)														---	---	---	---
NPNT	255743	broad.mit.edu	37	4	106848395	106848395	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:106848395delT	uc003hya.2	+						NPNT_uc011cfc.1_Intron|NPNT_uc011cfd.1_Intron|NPNT_uc011cfe.1_Intron|NPNT_uc010ilt.1_Intron|NPNT_uc011cff.1_Intron|NPNT_uc010ilu.1_Intron	NM_001033047	NP_001028219			nephronectin precursor						cell differentiation	membrane	calcium ion binding			skin(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.41e-07)														---	---	---	---
NPNT	255743	broad.mit.edu	37	4	106859656	106859656	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:106859656delA	uc003hya.2	+						NPNT_uc011cfc.1_Intron|NPNT_uc011cfd.1_Intron|NPNT_uc011cfe.1_Intron|NPNT_uc010ilt.1_Intron|NPNT_uc011cff.1_Intron|NPNT_uc010ilu.1_Intron	NM_001033047	NP_001028219			nephronectin precursor						cell differentiation	membrane	calcium ion binding			skin(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.41e-07)														---	---	---	---
TBCK	93627	broad.mit.edu	37	4	107229904	107229904	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:107229904delA	uc010ilv.2	-						TBCK_uc003hye.2_Intron|TBCK_uc003hyc.2_Intron|TBCK_uc003hyd.2_Intron|TBCK_uc003hyf.2_Intron	NM_001163435	NP_001156907			TBC domain-containing protein kinase-like							intracellular	Rab GTPase activator activity			large_intestine(2)|upper_aerodigestive_tract(1)|stomach(1)|ovary(1)	5																		---	---	---	---
PAPSS1	9061	broad.mit.edu	37	4	108603096	108603096	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:108603096delT	uc003hyk.2	-						PAPSS1_uc011cfh.1_Intron	NM_005443	NP_005434			3'-phosphoadenosine 5'-phosphosulfate synthase						3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|sulfate adenylyltransferase (ATP) activity			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.49e-05)														---	---	---	---
EGF	1950	broad.mit.edu	37	4	110866519	110866519	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:110866519delA	uc003hzy.3	+						EGF_uc011cfu.1_Intron|EGF_uc011cfv.1_Intron	NM_001963	NP_001954			epidermal growth factor precursor						angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)													---	---	---	---
EGF	1950	broad.mit.edu	37	4	110909149	110909149	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:110909149delA	uc003hzy.3	+						EGF_uc011cfu.1_Intron|EGF_uc011cfv.1_Intron|EGF_uc010imk.2_Intron	NM_001963	NP_001954			epidermal growth factor precursor						angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)													---	---	---	---
C4orf21	55345	broad.mit.edu	37	4	113540916	113540916	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:113540916delA	uc003iau.2	-						C4orf21_uc003iaw.2_Intron	NM_018392	NP_060862			prematurely terminated mRNA decay factor-like							integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)														---	---	---	---
Unknown	0	broad.mit.edu	37	4	113660329	113660329	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:113660329delA								LARP7 (81588 upstream) : ANK2 (78910 downstream)																																			---	---	---	---
ANK2	287	broad.mit.edu	37	4	114252857	114252857	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:114252857delT	uc003ibe.3	+						ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibc.2_Intron|ANK2_uc011cgb.1_Intron	NM_001148	NP_001139			ankyrin 2 isoform 1						axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)														---	---	---	---
ANK2	287	broad.mit.edu	37	4	114256883	114256883	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:114256883delA	uc003ibe.3	+						ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibc.2_Intron|ANK2_uc011cgb.1_Intron	NM_001148	NP_001139			ankyrin 2 isoform 1						axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)														---	---	---	---
ANK2	287	broad.mit.edu	37	4	114289147	114289147	+	Intron	DEL	A	-	-	rs55966162	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:114289147delA	uc003ibe.3	+						ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Intron	NM_001148	NP_001139			ankyrin 2 isoform 1						axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)														---	---	---	---
TRAM1L1	133022	broad.mit.edu	37	4	118005517	118005517	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:118005517delT	uc003ibv.3	-	1	1220	c.1033delA	c.(1033-1035)AGAfs	p.R345fs		NM_152402	NP_689615	Q8N609	TR1L1_HUMAN	translocation associated membrane protein 1-like	345	Cytoplasmic (Potential).				protein transport|transmembrane transport	endoplasmic reticulum membrane|integral to membrane				central_nervous_system(1)	1																		---	---	---	---
SEC24D	9871	broad.mit.edu	37	4	119654081	119654081	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:119654081delT	uc003ici.3	-						SEC24D_uc003ich.3_Intron|SEC24D_uc003icj.3_Intron|SEC24D_uc003ick.2_5'UTR	NM_014822	NP_055637			Sec24-related protein D						COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0																		---	---	---	---
SEC24D	9871	broad.mit.edu	37	4	119754994	119754994	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:119754994delA	uc003ici.3	-						SEC24D_uc003icj.3_Intron|SEC24D_uc003icl.2_Intron|SEC24D_uc010imz.1_Intron|SEC24D_uc011cgg.1_Intron	NM_014822	NP_055637			Sec24-related protein D						COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0																		---	---	---	---
TNIP3	79931	broad.mit.edu	37	4	122068097	122068097	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:122068097delA	uc010ing.2	-						TNIP3_uc010inh.2_Intron|TNIP3_uc011cgj.1_Intron	NM_024873	NP_079149			TNFAIP3 interacting protein 3											ovary(1)	1																		---	---	---	---
BBS7	55212	broad.mit.edu	37	4	122765171	122765171	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:122765171delA	uc003ied.2	-						BBS7_uc003iee.1_Intron	NM_176824	NP_789794			Bardet-Biedl syndrome 7 protein isoform a						cilium morphogenesis|digestive tract morphogenesis|fat cell differentiation|heart looping|melanosome transport|pigment granule aggregation in cell center|response to stimulus|visual perception	BBSome|centrosome|cilium membrane	protein binding			ovary(1)	1														Bardet-Biedl_syndrome				---	---	---	---
KIAA1109	84162	broad.mit.edu	37	4	123094172	123094173	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:123094172_123094173insT	uc003ieh.2	+							NM_015312	NP_056127			fragile site-associated protein						regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12																		---	---	---	---
KIAA1109	84162	broad.mit.edu	37	4	123164876	123164876	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:123164876delA	uc003ieh.2	+						KIAA1109_uc003iek.2_Intron	NM_015312	NP_056127			fragile site-associated protein						regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12																		---	---	---	---
KIAA1109	84162	broad.mit.edu	37	4	123167561	123167562	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:123167561_123167562insA	uc003ieh.2	+						KIAA1109_uc003iek.2_Intron	NM_015312	NP_056127			fragile site-associated protein						regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12																		---	---	---	---
KIAA1109	84162	broad.mit.edu	37	4	123260257	123260257	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:123260257delA	uc003ieh.2	+						KIAA1109_uc003iem.2_Intron|KIAA1109_uc003ien.2_5'Flank	NM_015312	NP_056127			fragile site-associated protein						regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12																		---	---	---	---
ADAD1	132612	broad.mit.edu	37	4	123342283	123342283	+	Intron	DEL	A	-	-	rs35017745		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:123342283delA	uc003ieo.2	+						ADAD1_uc003iep.2_Intron|ADAD1_uc003ieq.2_Intron	NM_139243	NP_640336			adenosine deaminase domain containing 1						multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding				0																		---	---	---	---
SPATA5	166378	broad.mit.edu	37	4	123859335	123859335	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:123859335delG	uc003iez.3	+	8	1462	c.1389delG	c.(1387-1389)GAGfs	p.E463fs	SPATA5_uc003iey.2_Frame_Shift_Del_p.E462fs	NM_145207	NP_660208	Q8NB90	SPAT5_HUMAN	spermatogenesis associated 5	463					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrion	ATP binding|nucleoside-triphosphatase activity				0																		---	---	---	---
SPRY1	10252	broad.mit.edu	37	4	124322624	124322625	+	Intron	DEL	CC	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:124322624_124322625delCC	uc003ifa.2	+						SPRY1_uc003ifb.2_Intron	NM_199327	NP_955359			sprouty homolog 1, antagonist of FGF signaling						epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|lamellipodium|plasma membrane				skin(2)|ovary(1)	3																		---	---	---	---
INTU	27152	broad.mit.edu	37	4	128625339	128625340	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:128625339_128625340insA	uc003ifk.1	+						INTU_uc011cgq.1_Intron	NM_015693	NP_056508			PDZ domain containing 6											ovary(1)	1																		---	---	---	---
SCLT1	132320	broad.mit.edu	37	4	129869675	129869675	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:129869675delT	uc003igp.2	-	15	1775	c.1269delA	c.(1267-1269)AAAfs	p.K423fs	SCLT1_uc003ign.2_Frame_Shift_Del_p.K87fs|SCLT1_uc003igo.2_Frame_Shift_Del_p.K33fs|SCLT1_uc003igq.2_Intron|SCLT1_uc010iob.1_Intron	NM_144643	NP_653244	Q96NL6	SCLT1_HUMAN	sodium channel associated protein 1	423	Potential.					centrosome				ovary(3)|lung(1)|central_nervous_system(1)	5																		---	---	---	---
CCRN4L	25819	broad.mit.edu	37	4	139964675	139964676	+	Intron	DEL	TT	-	-	rs74468507		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:139964675_139964676delTT	uc003ihl.2	+						CCRN4L_uc003ihk.1_3'UTR	NM_012118	NP_036250			CCR4 carbon catabolite repression 4-like						rhythmic process|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1	all_hematologic(180;0.162)																	---	---	---	---
ELF2	1998	broad.mit.edu	37	4	140036422	140036422	+	Intron	DEL	T	-	-	rs7661947		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:140036422delT	uc003ihp.1	-						ELF2_uc003ihq.2_Intron	NM_201999	NP_973728			E74-like factor 2 (ets domain transcription						negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2	all_hematologic(180;0.162)																	---	---	---	---
GAB1	2549	broad.mit.edu	37	4	144381841	144381841	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:144381841delA	uc003ije.2	+						GAB1_uc003ijd.2_Intron|GAB1_uc011chq.1_Intron	NM_002039	NP_002030			GRB2-associated binding protein 1 isoform b						cell proliferation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			breast(2)|lung(1)|skin(1)	4	all_hematologic(180;0.158)																	---	---	---	---
HHIP	64399	broad.mit.edu	37	4	145627734	145627734	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:145627734delA	uc003ijs.1	+	5	1538	c.883delA	c.(883-885)AAAfs	p.K295fs		NM_022475	NP_071920	Q96QV1	HHIP_HUMAN	hedgehog-interacting protein precursor	295						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)														---	---	---	---
ABCE1	6059	broad.mit.edu	37	4	146041093	146041093	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:146041093delT	uc003ijx.2	+	11	1372	c.932delT	c.(931-933)ATTfs	p.I311fs	ABCE1_uc003ijy.2_Frame_Shift_Del_p.I311fs|ABCE1_uc010iot.2_RNA	NM_001040876	NP_001035809	P61221	ABCE1_HUMAN	ATP-binding cassette, sub-family E, member 1	311	ABC transporter 1.				interspecies interaction between organisms|response to virus|RNA catabolic process	mitochondrion	ATP binding|ATPase activity|electron carrier activity|iron-sulfur cluster binding|ribonuclease inhibitor activity			skin(1)	1	all_hematologic(180;0.151)																	---	---	---	---
Unknown	0	broad.mit.edu	37	4	146377564	146377564	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:146377564delA								OTUD4 (276732 upstream) : SMAD1 (25387 downstream)																																			---	---	---	---
C4orf51	646603	broad.mit.edu	37	4	146650450	146650458	+	Intron	DEL	TTTTTTTTT	-	-	rs34953887		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:146650450_146650458delTTTTTTTTT	uc003ikk.2	+							NM_001080531	NP_001074000			chromosome 4 open reading frame 51												0																		---	---	---	---
PRMT10	90826	broad.mit.edu	37	4	148575739	148575739	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:148575739delA	uc003ilc.2	-						PRMT10_uc003ilb.2_Intron|PRMT10_uc003ild.2_Intron	NM_138364	NP_612373			protein arginine methyltransferase 10							cytoplasm	binding|protein methyltransferase activity			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
LRBA	987	broad.mit.edu	37	4	151642666	151642667	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:151642666_151642667delTT	uc010ipj.2	-						LRBA_uc003ilt.3_Intron|LRBA_uc003ilu.3_Intron	NM_006726	NP_006717			LPS-responsive vesicle trafficking, beach and							endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)																	---	---	---	---
LRBA	987	broad.mit.edu	37	4	151769837	151769837	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:151769837delA	uc010ipj.2	-						LRBA_uc003ilt.3_Intron|LRBA_uc003ilu.3_Intron	NM_006726	NP_006717			LPS-responsive vesicle trafficking, beach and							endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)																	---	---	---	---
TRIM2	23321	broad.mit.edu	37	4	154098799	154098800	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:154098799_154098800delAA	uc003ing.2	+							NM_001130067	NP_001123539			tripartite motif-containing 2 isoform 2							cytoplasm	zinc ion binding			central_nervous_system(1)	1	all_hematologic(180;0.093)	Medulloblastoma(177;0.00225)		GBM - Glioblastoma multiforme(119;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0703)														---	---	---	---
TRIM2	23321	broad.mit.edu	37	4	154243998	154243998	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:154243998delT	uc003ing.2	+						TRIM2_uc003inh.2_Intron	NM_001130067	NP_001123539			tripartite motif-containing 2 isoform 2							cytoplasm	zinc ion binding			central_nervous_system(1)	1	all_hematologic(180;0.093)	Medulloblastoma(177;0.00225)		GBM - Glioblastoma multiforme(119;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0703)														---	---	---	---
PLRG1	5356	broad.mit.edu	37	4	155468219	155468219	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:155468219delA	uc003iny.2	-						PLRG1_uc003inz.2_Intron|PLRG1_uc011cil.1_Intron	NM_002669	NP_002660			pleiotropic regulator 1 (PRL1 homolog,							catalytic step 2 spliceosome|nuclear speck	protein binding|signal transducer activity|transcription corepressor activity				0	all_hematologic(180;0.215)	Renal(120;0.0854)																---	---	---	---
PLRG1	5356	broad.mit.edu	37	4	155469817	155469817	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:155469817delA	uc003iny.2	-						PLRG1_uc003inz.2_Intron|PLRG1_uc011cil.1_Intron	NM_002669	NP_002660			pleiotropic regulator 1 (PRL1 homolog,							catalytic step 2 spliceosome|nuclear speck	protein binding|signal transducer activity|transcription corepressor activity				0	all_hematologic(180;0.215)	Renal(120;0.0854)																---	---	---	---
FGA	2243	broad.mit.edu	37	4	155505988	155505988	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:155505988delA	uc003iod.1	-							NM_000508	NP_000499			fibrinogen, alpha polypeptide isoform alpha-E						platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)													---	---	---	---
RBM46	166863	broad.mit.edu	37	4	155720146	155720146	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:155720146delT	uc003ioo.2	+	4	1005	c.832delT	c.(832-834)TTTfs	p.F278fs	RBM46_uc011cim.1_Frame_Shift_Del_p.F278fs|RBM46_uc003iop.1_Frame_Shift_Del_p.F278fs	NM_144979	NP_659416	Q8TBY0	RBM46_HUMAN	RNA binding motif protein 46	278	RRM 3.						nucleotide binding|RNA binding			central_nervous_system(1)|skin(1)	2	all_hematologic(180;0.24)	Renal(120;0.0854)																---	---	---	---
RAPGEF2	9693	broad.mit.edu	37	4	160259361	160259361	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:160259361delA	uc003iqg.3	+							NM_014247	NP_055062			Rap guanine nucleotide exchange factor 2						cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			lung(2)|upper_aerodigestive_tract(1)|skin(1)	4	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)														---	---	---	---
RAPGEF2	9693	broad.mit.edu	37	4	160263384	160263384	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:160263384delT	uc003iqg.3	+							NM_014247	NP_055062			Rap guanine nucleotide exchange factor 2						cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			lung(2)|upper_aerodigestive_tract(1)|skin(1)	4	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)														---	---	---	---
SPOCK3	50859	broad.mit.edu	37	4	167810410	167810410	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:167810410delA	uc003iri.1	-						SPOCK3_uc011cjp.1_Intron|SPOCK3_uc011cjq.1_Intron|SPOCK3_uc011cjr.1_Intron|SPOCK3_uc003irj.1_Intron|SPOCK3_uc011cjs.1_Intron|SPOCK3_uc011cjt.1_Intron|SPOCK3_uc011cju.1_Intron|SPOCK3_uc011cjv.1_Intron|SPOCK3_uc003irk.3_Intron|SPOCK3_uc011cjw.1_Intron	NM_016950	NP_058646			testican 3 isoform 2						signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)														---	---	---	---
DDX60	55601	broad.mit.edu	37	4	169142737	169142737	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:169142737delA	uc003irp.2	-						DDX60_uc003iro.2_Intron	NM_017631	NP_060101			DEAD (Asp-Glu-Ala-Asp) box polypeptide 60								ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)														---	---	---	---
DDX60	55601	broad.mit.edu	37	4	169204564	169204564	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:169204564delT	uc003irp.2	-							NM_017631	NP_060101			DEAD (Asp-Glu-Ala-Asp) box polypeptide 60								ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)														---	---	---	---
DDX60L	91351	broad.mit.edu	37	4	169292766	169292766	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:169292766delT	uc003irq.3	-	36	5146	c.4925delA	c.(4924-4926)AATfs	p.N1642fs		NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	1642							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)														---	---	---	---
HAND2	9464	broad.mit.edu	37	4	174450193	174450194	+	Frame_Shift_Ins	INS	-	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:174450193_174450194insC	uc003ith.1	-	1	1185_1186	c.247_248insG	c.(247-249)GTGfs	p.V83fs	NBLA00301_uc011ckd.1_5'Flank|NBLA00301_uc003itl.3_5'Flank|NBLA00301_uc003itj.2_5'Flank|NBLA00301_uc010irf.2_5'Flank|NBLA00301_uc010irg.2_5'Flank|NBLA00301_uc010irh.2_5'Flank|NBLA00301_uc010iri.2_5'Flank|NBLA00301_uc010irj.2_5'Flank|NBLA00301_uc010irk.2_5'Flank|NBLA00301_uc010irl.2_5'Flank|NBLA00301_uc010irm.2_5'Flank|NBLA00301_uc010irn.2_5'Flank|NBLA00301_uc003itk.2_5'Flank|HAND2_uc003itg.1_Intron|HAND2_uc010ire.1_Frame_Shift_Ins_p.V83fs	NM_021973	NP_068808	P61296	HAND2_HUMAN	basic helix-loop-helix transcription factor	83					adult heart development|angiogenesis|apoptosis|cardiac neural crest cell development involved in outflow tract morphogenesis|heart looping|in utero embryonic development|negative regulation of cardiac muscle cell apoptosis|noradrenergic neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|regulation of secondary heart field cardioblast proliferation|thymus development	nuclear chromatin|transcription factor complex	activating transcription factor binding|protein homodimerization activity|RNA polymerase II regulatory region sequence-specific DNA binding|transcription coactivator activity			skin(1)	1		Prostate(90;0.00601)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0837)|all_hematologic(60;0.107)		all cancers(43;1.37e-18)|Epithelial(43;5.5e-17)|OV - Ovarian serous cystadenocarcinoma(60;3.3e-10)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)														---	---	---	---
GPM6A	2823	broad.mit.edu	37	4	176556323	176556323	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:176556323delA	uc003iuf.2	-						GPM6A_uc011ckj.1_Intron|GPM6A_uc003iug.2_Intron|GPM6A_uc003iuh.2_Intron	NM_201591	NP_963885			glycoprotein M6A isoform 2							cell surface|integral to membrane					0		Breast(14;7.35e-05)|Melanoma(52;0.00909)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;9.21e-19)|Epithelial(43;3.01e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.02e-09)|STAD - Stomach adenocarcinoma(60;0.00083)|GBM - Glioblastoma multiforme(59;0.00168)|LUSC - Lung squamous cell carcinoma(193;0.0388)														---	---	---	---
WDR17	116966	broad.mit.edu	37	4	177029098	177029098	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:177029098delT	uc003iuj.2	+						WDR17_uc003iuk.2_Intron|WDR17_uc003ium.3_Intron|WDR17_uc003iul.1_Intron	NM_170710	NP_733828			WD repeat domain 17 isoform 1											ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)														---	---	---	---
SPATA4	132851	broad.mit.edu	37	4	177109229	177109229	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:177109229delA	uc003iuo.1	-							NM_144644	NP_653245			spermatogenesis associated 4						apoptosis|spermatogenesis						0		Breast(14;0.0011)|Prostate(90;0.0129)|Melanoma(52;0.0133)|Renal(120;0.0376)|all_hematologic(60;0.124)		all cancers(43;2.9e-20)|Epithelial(43;1.99e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.58e-09)|GBM - Glioblastoma multiforme(59;0.000162)|STAD - Stomach adenocarcinoma(60;0.000543)|LUSC - Lung squamous cell carcinoma(193;0.096)														---	---	---	---
RWDD4A	201965	broad.mit.edu	37	4	184562626	184562626	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:184562626delA	uc003ivt.1	-							NM_152682	NP_689895			RWD domain containing 4A												0		all_lung(41;4.4e-14)|Lung NSC(41;1.03e-13)|Colorectal(36;0.00139)|all_hematologic(60;0.00756)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.202)		all cancers(43;7.35e-27)|Epithelial(43;1.49e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.76e-10)|GBM - Glioblastoma multiforme(59;5.54e-06)|Colorectal(24;7.92e-06)|STAD - Stomach adenocarcinoma(60;2.35e-05)|COAD - Colon adenocarcinoma(29;6.26e-05)|LUSC - Lung squamous cell carcinoma(40;0.00935)|READ - Rectum adenocarcinoma(43;0.166)														---	---	---	---
ENPP6	133121	broad.mit.edu	37	4	185037923	185037923	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:185037923delA	uc003iwc.2	-							NM_153343	NP_699174			ectonucleotide pyrophosphatase/phosphodiesterase						lipid catabolic process	extracellular region|integral to membrane|plasma membrane				central_nervous_system(1)	1		all_lung(41;7.99e-12)|Lung NSC(41;1.46e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;4.98e-27)|Epithelial(43;3.15e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.09e-12)|Colorectal(24;3.78e-05)|STAD - Stomach adenocarcinoma(60;4.5e-05)|COAD - Colon adenocarcinoma(29;0.000154)|GBM - Glioblastoma multiforme(59;0.000167)|BRCA - Breast invasive adenocarcinoma(30;0.000378)|LUSC - Lung squamous cell carcinoma(40;0.0151)														---	---	---	---
CCDC111	201973	broad.mit.edu	37	4	185578560	185578560	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:185578560delA	uc003iwk.2	+						CCDC111_uc010isd.1_Intron|CCDC111_uc003iwj.2_Intron|CCDC111_uc003iwl.2_Intron|CCDC111_uc003iwm.2_Intron|CCDC111_uc003iwn.2_Intron	NM_152683	NP_689896			coiled-coil domain containing 111						DNA replication, synthesis of RNA primer		DNA primase activity			central_nervous_system(1)	1		all_lung(41;9.65e-12)|Lung NSC(41;1.64e-11)|Colorectal(36;0.00531)|Hepatocellular(41;0.00932)|Renal(120;0.0246)|Prostate(90;0.0283)|all_hematologic(60;0.0749)|all_neural(102;0.131)		all cancers(43;5.84e-27)|Epithelial(43;2.2e-23)|OV - Ovarian serous cystadenocarcinoma(60;4.28e-11)|STAD - Stomach adenocarcinoma(60;2.66e-05)|GBM - Glioblastoma multiforme(59;3.03e-05)|Colorectal(24;7.57e-05)|BRCA - Breast invasive adenocarcinoma(30;0.000249)|COAD - Colon adenocarcinoma(29;0.000502)|LUSC - Lung squamous cell carcinoma(40;0.00995)|READ - Rectum adenocarcinoma(43;0.173)														---	---	---	---
Unknown	0	broad.mit.edu	37	4	185999441	185999441	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:185999441delA	uc003ixc.1	+											Homo sapiens clone UT2 unknown mRNA.																														---	---	---	---
SORBS2	8470	broad.mit.edu	37	4	186533227	186533228	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:186533227_186533228insT	uc003iyl.2	-						SORBS2_uc003iyh.2_Intron|SORBS2_uc011ckw.1_Intron|SORBS2_uc003iyi.2_Intron|SORBS2_uc011ckx.1_Intron|SORBS2_uc003iyk.2_Intron|SORBS2_uc003iym.2_Intron|SORBS2_uc003iyn.1_Intron|SORBS2_uc011cku.1_Intron|SORBS2_uc011ckv.1_Intron|SORBS2_uc003iyd.2_Intron|SORBS2_uc003iye.2_Intron|SORBS2_uc003iya.2_Intron|SORBS2_uc003iyb.2_Intron|SORBS2_uc003iyc.2_Intron|SORBS2_uc003iyg.2_Intron|SORBS2_uc003iyf.2_Intron|SORBS2_uc003iyo.1_Intron	NM_021069	NP_066547			sorbin and SH3 domain containing 2 isoform 2							actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)														---	---	---	---
FAT1	2195	broad.mit.edu	37	4	187530579	187530579	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:187530579delT	uc003izf.2	-							NM_005245	NP_005236			FAT tumor suppressor 1 precursor						actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12															HNSCC(5;0.00058)			---	---	---	---
FAT1	2195	broad.mit.edu	37	4	187532425	187532425	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:187532425delT	uc003izf.2	-							NM_005245	NP_005236			FAT tumor suppressor 1 precursor						actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12															HNSCC(5;0.00058)			---	---	---	---
CEP72	55722	broad.mit.edu	37	5	647897	647897	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:647897delT	uc003jbf.2	+							NM_018140	NP_060610			centrosomal protein 72 kDa						G2/M transition of mitotic cell cycle|gamma-tubulin complex localization|spindle organization	centrosome|cytosol				ovary(1)	1			Epithelial(17;0.000339)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|Lung(60;0.0863)															---	---	---	---
SLC12A7	10723	broad.mit.edu	37	5	1074698	1074698	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:1074698delG	uc003jbu.2	-	16	2122	c.2056delC	c.(2056-2058)CACfs	p.H686fs		NM_006598	NP_006589	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride	686					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			skin(2)|large_intestine(1)|ovary(1)	4	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)													---	---	---	---
SDHAP3	728609	broad.mit.edu	37	5	1589488	1589488	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:1589488delA	uc010itg.1	-						SDHAP3_uc011cme.1_Intron					Homo sapiens cDNA clone IMAGE:40127561.												0																		---	---	---	---
IRX1	79192	broad.mit.edu	37	5	3599265	3599266	+	Intron	DEL	TC	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:3599265_3599266delTC	uc003jde.2	+							NM_024337	NP_077313			iroquois homeobox protein 1							nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2																		---	---	---	---
MED10	84246	broad.mit.edu	37	5	6374356	6374357	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:6374356_6374357insA	uc003jdo.2	-							NM_032286	NP_115662			mediator complex subunit 10						regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(1)	1																		---	---	---	---
NSUN2	54888	broad.mit.edu	37	5	6623158	6623160	+	Intron	DEL	AAA	-	-	rs111573762		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:6623158_6623160delAAA	uc003jdu.2	-						NSUN2_uc003jdt.2_5'Flank|NSUN2_uc011cmk.1_Intron|NSUN2_uc003jdv.2_Intron	NM_017755	NP_060225			NOL1/NOP2/Sun domain family, member 2							cytoplasm|nucleolus	tRNA (cytosine-5-)-methyltransferase activity|tRNA binding			ovary(1)	1																		---	---	---	---
MARCH6	10299	broad.mit.edu	37	5	10415851	10415851	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:10415851delT	uc003jet.1	+						MARCH6_uc011cmu.1_Intron|MARCH6_uc003jeu.1_Intron|MARCH6_uc011cmv.1_Intron	NM_005885	NP_005876			membrane-associated ring finger (C3HC4) 6						protein K48-linked ubiquitination	integral to endoplasmic reticulum membrane	ubiquitin conjugating enzyme binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|breast(1)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	5	13637975	13637975	+	IGR	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:13637975delG								None (None upstream) : DNAH5 (52462 downstream)																																			---	---	---	---
TRIO	7204	broad.mit.edu	37	5	14287249	14287249	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:14287249delT	uc003jff.2	+						TRIO_uc003jfg.2_Intron|TRIO_uc011cna.1_Intron	NM_007118	NP_009049			triple functional domain (PTPRF interacting)						apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)																	---	---	---	---
TRIO	7204	broad.mit.edu	37	5	14477004	14477004	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:14477004delT	uc003jff.2	+	41	6091	c.6085delT	c.(6085-6087)TTTfs	p.F2029fs	TRIO_uc003jfg.2_RNA|TRIO_uc003jfh.1_Frame_Shift_Del_p.F1678fs	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	2029	DH 2.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)																	---	---	---	---
TRIO	7204	broad.mit.edu	37	5	14487781	14487781	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:14487781delC	uc003jff.2	+	48	7050	c.7044delC	c.(7042-7044)CACfs	p.H2348fs	TRIO_uc003jfg.2_RNA|TRIO_uc003jfh.1_Frame_Shift_Del_p.H1997fs	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	2348					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)																	---	---	---	---
Unknown	0	broad.mit.edu	37	5	17104556	17104556	+	IGR	DEL	C	-	-	rs67381352		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:17104556delC								MYO10 (168171 upstream) : LOC285696 (25581 downstream)																																			---	---	---	---
LOC285696	285696	broad.mit.edu	37	5	17202758	17202758	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:17202758delT	uc003jfw.2	-							NR_027253				Homo sapiens cDNA FLJ34047 fis, clone FCBBF3000001.												0																		---	---	---	---
RNASEN	29102	broad.mit.edu	37	5	31508945	31508945	+	Intron	DEL	C	-	-	rs111921186	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:31508945delC	uc003jhg.2	-						RNASEN_uc003jhh.2_Intron|RNASEN_uc003jhi.2_Intron|RNASEN_uc010iui.1_Intron	NM_013235	NP_037367			ribonuclease III, nuclear isoform 1						gene silencing by RNA|ribosome biogenesis|RNA processing	nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity				0																		---	---	---	---
C5orf22	55322	broad.mit.edu	37	5	31545963	31545963	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:31545963delA	uc003jhj.3	+						C5orf22_uc011cnw.1_Intron|C5orf22_uc003jhk.3_Intron|C5orf22_uc010iuj.2_Intron	NM_018356	NP_060826			hypothetical protein LOC55322											ovary(2)	2																		---	---	---	---
PDZD2	23037	broad.mit.edu	37	5	32037569	32037569	+	Intron	DEL	A	-	-	rs923834	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:32037569delA	uc003jhl.2	+						PDZD2_uc003jhm.2_Intron|PDZD2_uc011cnx.1_Intron	NM_178140	NP_835260			PDZ domain containing 2						cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9																		---	---	---	---
Unknown	0	broad.mit.edu	37	5	32888053	32888053	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:32888053delT								C5orf23 (96234 upstream) : TARS (552749 downstream)																																			---	---	---	---
RAI14	26064	broad.mit.edu	37	5	34814751	34814751	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:34814751delT	uc003jir.2	+	12	1112	c.916delT	c.(916-918)TTTfs	p.F306fs	RAI14_uc010iur.2_Frame_Shift_Del_p.F277fs|RAI14_uc011coj.1_Frame_Shift_Del_p.F306fs|RAI14_uc010ius.1_Frame_Shift_Del_p.F235fs|RAI14_uc003jis.2_Frame_Shift_Del_p.F309fs|RAI14_uc003jit.2_Frame_Shift_Del_p.F306fs|RAI14_uc011cok.1_Frame_Shift_Del_p.F298fs	NM_015577	NP_056392	Q9P0K7	RAI14_HUMAN	retinoic acid induced 14 isoform a	306						cell cortex|cytoskeleton	protein binding			ovary(1)	1	all_lung(31;0.000191)																	---	---	---	---
TTC23L	153657	broad.mit.edu	37	5	34861084	34861084	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:34861084delT	uc003jiu.2	+							NM_144725	NP_653326			tetratricopeptide repeat domain 23-like								binding			central_nervous_system(1)	1																		---	---	---	---
SPEF2	79925	broad.mit.edu	37	5	35705894	35705894	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:35705894delA	uc003jjo.2	+	18	2760	c.2649delA	c.(2647-2649)GCAfs	p.A883fs	SPEF2_uc003jjq.3_Frame_Shift_Del_p.A878fs|SPEF2_uc003jjp.1_Frame_Shift_Del_p.A369fs	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	883	Potential.				nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)															---	---	---	---
NIPBL	25836	broad.mit.edu	37	5	37044327	37044327	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:37044327delT	uc003jkl.3	+						NIPBL_uc003jkk.3_Intron	NM_133433	NP_597677			delangin isoform A						brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)															---	---	---	---
NIPBL	25836	broad.mit.edu	37	5	37064603	37064603	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:37064603delT	uc003jkl.3	+						NIPBL_uc003jkk.3_3'UTR|NIPBL_uc003jkn.2_Intron	NM_133433	NP_597677			delangin isoform A						brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)															---	---	---	---
NIPBL	25836	broad.mit.edu	37	5	37065070	37065070	+	3'UTR	DEL	A	-	-	rs71759480		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:37065070delA	uc003jkl.3	+	47					NIPBL_uc003jkk.3_3'UTR|NIPBL_uc003jkn.2_3'UTR	NM_133433	NP_597677			delangin isoform A						brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)															---	---	---	---
C5orf42	65250	broad.mit.edu	37	5	37130496	37130496	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:37130496delA	uc011cpa.1	-						C5orf42_uc003jkp.1_Intron|C5orf42_uc011coy.1_Intron|C5orf42_uc003jks.2_Intron|C5orf42_uc011coz.1_Intron	NM_023073	NP_075561			hypothetical protein LOC65250											ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)															---	---	---	---
C5orf42	65250	broad.mit.edu	37	5	37162611	37162611	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:37162611delT	uc011cpa.1	-	38	7877	c.7646delA	c.(7645-7647)AAGfs	p.K2549fs	C5orf42_uc011coy.1_Frame_Shift_Del_p.K1049fs|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Frame_Shift_Del_p.K1624fs	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	2549										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)															---	---	---	---
C5orf42	65250	broad.mit.edu	37	5	37168791	37168791	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:37168791delT	uc011cpa.1	-						C5orf42_uc011coy.1_Intron|C5orf42_uc003jks.2_Intron|C5orf42_uc011coz.1_Intron	NM_023073	NP_075561			hypothetical protein LOC65250											ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)															---	---	---	---
C5orf42	65250	broad.mit.edu	37	5	37169770	37169770	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:37169770delA	uc011cpa.1	-						C5orf42_uc011coy.1_Intron|C5orf42_uc003jks.2_Intron|C5orf42_uc011coz.1_Intron|C5orf42_uc003jkr.1_Intron	NM_023073	NP_075561			hypothetical protein LOC65250											ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)															---	---	---	---
C9	735	broad.mit.edu	37	5	39341843	39341843	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:39341843delA	uc003jlv.3	-							NM_001737	NP_001728			complement component 9 precursor						complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex					0	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)															---	---	---	---
ISL1	3670	broad.mit.edu	37	5	50687458	50687458	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:50687458delT	uc003jor.2	+							NM_002202	NP_002193			islet-1						generation of precursor metabolites and energy|multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3		Lung NSC(810;0.000845)|Breast(144;0.0411)																---	---	---	---
ITGA1	3672	broad.mit.edu	37	5	52211274	52211274	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:52211274delT	uc003jou.2	+						ITGA1_uc003jov.2_Intron|ITGA1_uc003jow.2_Intron	NM_181501	NP_852478			integrin, alpha 1 precursor						axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|muscle contraction	integrin complex	collagen binding|receptor activity			ovary(2)|lung(1)	3		Lung NSC(810;5.05e-05)|Breast(144;0.0851)																---	---	---	---
ARL15	54622	broad.mit.edu	37	5	53467775	53467775	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:53467775delA	uc003jpg.1	-						ARL15_uc010ivs.1_Intron	NM_019087	NP_061960			ADP-ribosylation factor-like 15								GTP binding			ovary(1)	1		Lung NSC(810;0.000779)																---	---	---	---
Unknown	0	broad.mit.edu	37	5	54221410	54221410	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:54221410delT								SNX18 (378995 upstream) : ESM1 (52286 downstream)																																			---	---	---	---
GZMA	3001	broad.mit.edu	37	5	54398401	54398401	+	5'Flank	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:54398401delA	uc003jpm.2	+							NM_006144	NP_006135			granzyme A precursor						cleavage of lamin|cytolysis|immune response|negative regulation of DNA binding|negative regulation of endodeoxyribonuclease activity|negative regulation of oxidoreductase activity|positive regulation of apoptosis	extracellular region|immunological synapse|nucleus	protein homodimerization activity|serine-type endopeptidase activity			ovary(2)|pancreas(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.183)																---	---	---	---
CDC20B	166979	broad.mit.edu	37	5	54468275	54468275	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:54468275delT	uc003jpo.1	-						CDC20B_uc003jpn.1_Intron|CDC20B_uc010ivu.1_Intron|CDC20B_uc010ivv.1_Intron|CDC20B_uc003jpp.2_Intron|MIR449A_hsa-mir-449a|MI0001648_5'Flank|uc011cqh.1_5'Flank|MIR449B_hsa-mir-449b|MI0003673_5'Flank|MIR449C_hsa-mir-449c|MI0003823_5'Flank	NM_152623	NP_689836			CDC20 cell division cycle 20 homolog B isoform												0		Lung NSC(810;0.000744)|Breast(144;0.159)|Prostate(74;0.194)	LUSC - Lung squamous cell carcinoma(15;0.225)															---	---	---	---
DDX4	54514	broad.mit.edu	37	5	55077069	55077069	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:55077069delT	uc003jqg.3	+						DDX4_uc010ivz.2_Intron|DDX4_uc003jqh.3_Intron|DDX4_uc003jqj.2_Intron	NM_001136034	NP_001129506			DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform						multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|skin(1)	2		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)																---	---	---	---
IL31RA	133396	broad.mit.edu	37	5	55147283	55147283	+	5'Flank	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:55147283delA	uc003jql.2	+						IL31RA_uc003jqk.2_5'Flank|IL31RA_uc011cqj.1_5'Flank|IL31RA_uc003jqm.2_5'Flank|IL31RA_uc003jqn.2_5'Flank|IL31RA_uc010iwa.1_5'Flank|IL31RA_uc003jqo.2_5'Flank	NM_139017	NP_620586			gp130-like monocyte receptor						anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			ovary(1)	1		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)																---	---	---	---
PDE4D	5144	broad.mit.edu	37	5	58520135	58520136	+	Intron	INS	-	AA	AA			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:58520135_58520136insAA	uc003jsa.2	-						PDE4D_uc003jrx.2_Intron|PDE4D_uc003jry.2_Intron|PDE4D_uc003jrz.2_Intron|PDE4D_uc003jsb.2_Intron|PDE4D_uc003jsc.2_Intron|PDE4D_uc003jrv.2_Intron|PDE4D_uc003jrw.2_Intron	NM_001104631	NP_001098101			phosphodiesterase 4D isoform 1						signal transduction	cytosol|insoluble fraction|membrane|microtubule organizing center|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(5;6.5e-58)|all_epithelial(5;1.75e-57)|all_lung(5;6.84e-18)|Lung NSC(5;1.29e-17)|Melanoma(5;0.00168)|Prostate(74;0.00234)|Colorectal(97;0.00629)|Ovarian(174;0.00832)|Breast(144;0.00996)|all_hematologic(6;0.0344)|Hepatocellular(6;0.0742)|Esophageal squamous(6;0.0954)		Epithelial(2;2.6e-55)|all cancers(2;2.66e-49)|OV - Ovarian serous cystadenocarcinoma(10;1.48e-39)|Colorectal(2;8.29e-08)|Lung(2;4.47e-07)|STAD - Stomach adenocarcinoma(2;1.11e-05)|COAD - Colon adenocarcinoma(2;0.00012)|LUSC - Lung squamous cell carcinoma(2;0.000775)|LUAD - Lung adenocarcinoma(3;0.0173)|READ - Rectum adenocarcinoma(2;0.0276)	Adenosine monophosphate(DB00131)|Dyphylline(DB00651)													---	---	---	---
SFRS12IP1	285672	broad.mit.edu	37	5	64023941	64023941	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:64023941delT	uc003jtk.2	-	4	423	c.271delA	c.(271-273)AGGfs	p.R91fs		NM_173829	NP_776190	Q8N9Q2	SR1IP_HUMAN	P18SRP protein	91	Lys-rich.				mRNA processing|RNA splicing		nucleic acid binding|zinc ion binding				0		Lung NSC(167;1.66e-05)|Prostate(74;0.0138)|Ovarian(174;0.0545)|Colorectal(97;0.234)		Lung(70;0.119)														---	---	---	---
TRIM23	373	broad.mit.edu	37	5	64890479	64890479	+	Intron	DEL	A	-	-	rs61511730	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:64890479delA	uc003jty.2	-						TRIM23_uc003jtw.2_Intron|TRIM23_uc003jtx.2_Intron	NM_001656	NP_001647			ADP-ribosylation factor domain protein 1 isoform						interspecies interaction between organisms|small GTPase mediated signal transduction	Golgi membrane|lysosomal membrane	enzyme activator activity|GDP binding|GTP binding|GTPase activity|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|lung(1)	4		Lung NSC(167;3.24e-06)|Prostate(74;0.0138)|Breast(144;0.0433)|Ovarian(174;0.0545)|Colorectal(97;0.234)		Lung(70;0.00473)														---	---	---	---
C5orf44	80006	broad.mit.edu	37	5	64933654	64933654	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:64933654delT	uc003jtz.3	+						C5orf44_uc003jua.3_Intron|C5orf44_uc003juc.3_Intron|C5orf44_uc010iwv.2_Intron	NM_024941	NP_079217			hypothetical protein LOC80006 isoform 2											ovary(1)	1																		---	---	---	---
C5orf44	80006	broad.mit.edu	37	5	64948167	64948167	+	Intron	DEL	T	-	-	rs72456938		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:64948167delT	uc003jtz.3	+						C5orf44_uc003jua.3_Intron|C5orf44_uc003juc.3_Intron|C5orf44_uc010iwv.2_Intron	NM_024941	NP_079217			hypothetical protein LOC80006 isoform 2											ovary(1)	1																		---	---	---	---
NLN	57486	broad.mit.edu	37	5	65108412	65108412	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:65108412delA	uc003juf.2	+						NLN_uc003jug.2_Intron|NLN_uc010iww.2_Intron	NM_020726	NP_065777			neurolysin precursor						proteolysis	mitochondrial intermembrane space	metal ion binding|metalloendopeptidase activity			central_nervous_system(1)	1		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0743)|Lung(70;0.00616)														---	---	---	---
Unknown	0	broad.mit.edu	37	5	65173033	65173033	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:65173033delT								NLN (53646 upstream) : ERBB2IP (49351 downstream)																																			---	---	---	---
SFRS12	140890	broad.mit.edu	37	5	65457915	65457916	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:65457915_65457916insT	uc003juo.2	+						SFRS12_uc003jun.2_Intron|SFRS12_uc010iwy.2_Intron	NM_139168	NP_631907			splicing factor, arginine/serine-rich 12 isoform						mRNA processing|RNA splicing	spliceosomal complex	nucleic acid binding|nucleotide binding|protein binding				0		Lung NSC(167;9.34e-06)|Prostate(74;0.00187)|Ovarian(174;0.0545)|Breast(144;0.0928)|Colorectal(97;0.234)		Lung(70;0.00449)														---	---	---	---
MAST4	375449	broad.mit.edu	37	5	66300755	66300755	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:66300755delT	uc003jut.1	+						MAST4_uc003jus.2_Intron|MAST4_uc003juu.1_Intron|MAST4_uc011cra.1_Intron|MAST4_uc010ixa.2_RNA|MAST4_uc003juv.2_5'UTR|MAST4_uc003juw.2_5'Flank	NM_015183	NP_055998			microtubule associated serine/threonine kinase							cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)														---	---	---	---
SLC30A5	64924	broad.mit.edu	37	5	68399960	68399960	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:68399960delT	uc003jvh.2	+						SLC30A5_uc003jvg.2_3'UTR|SLC30A5_uc011crc.1_RNA|SLC30A5_uc003jvi.2_Intron	NM_022902	NP_075053			solute carrier family 30 (zinc transporter),						cellular zinc ion homeostasis|cobalt ion transport|regulation of proton transport|response to zinc ion	apical plasma membrane|Golgi apparatus|integral to plasma membrane|membrane fraction|secretory granule membrane	zinc ion binding|zinc ion transmembrane transporter activity			central_nervous_system(1)	1		Lung NSC(167;0.000986)|Prostate(74;0.00809)|Colorectal(97;0.0508)|Ovarian(174;0.16)		OV - Ovarian serous cystadenocarcinoma(47;1.24e-56)|Epithelial(20;1.12e-52)|all cancers(19;2.63e-48)|Lung(70;0.0177)														---	---	---	---
CCDC125	202243	broad.mit.edu	37	5	68581142	68581142	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:68581142delA	uc003jvv.1	-						CCDC125_uc003jvx.1_Intron|CCDC125_uc003jvy.1_Intron|CCDC125_uc003jvw.2_Intron	NM_176816	NP_789786			coiled-coil domain containing 125							cytoplasm					0		Lung NSC(167;7.26e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.2e-56)|Epithelial(20;2.31e-52)|all cancers(19;5.85e-48)|Lung(70;0.0183)														---	---	---	---
NAIP	4671	broad.mit.edu	37	5	70357189	70357189	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:70357189delC	uc003kat.1	-						GTF2H2_uc003kav.3_Intron|GTF2H2_uc003kau.3_Intron|GTF2H2_uc011crt.1_Intron|GTF2H2_uc003kay.1_Intron|GTF2H2_uc003kaz.2_Intron	NM_022892	NP_075043			NLR family, apoptosis inhibitory protein isoform						anti-apoptosis|apoptosis|nervous system development	basolateral plasma membrane|cytoplasm	caspase inhibitor activity|metal ion binding|nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(1)	1		Lung NSC(167;4.15e-05)|Prostate(74;0.00996)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;3.04e-60)|Epithelial(20;7.09e-58)|all cancers(19;1.13e-53)|Lung(70;0.0174)														---	---	---	---
MCCC2	64087	broad.mit.edu	37	5	70939898	70939901	+	Intron	DEL	GCGC	-	-	rs61210707	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:70939898_70939901delGCGC	uc003kbs.3	+						MCCC2_uc003kbt.3_Intron	NM_022132	NP_071415			methylcrotonoyl-Coenzyme A carboxylase 2 (beta)						leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)	1		Lung NSC(167;0.000697)|Prostate(74;0.0107)|Ovarian(174;0.0175)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.04e-54)	Biotin(DB00121)													---	---	---	---
RGNEF	64283	broad.mit.edu	37	5	73141989	73141989	+	Intron	DEL	C	-	-	rs72772523	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:73141989delC	uc011csq.1	+						RGNEF_uc003kcx.2_Intron|RGNEF_uc003kcy.1_Intron|RGNEF_uc010izf.2_Intron|RGNEF_uc011csr.1_Intron	NM_001080479	NP_001073948			Rho-guanine nucleotide exchange factor						cell differentiation|intracellular signal transduction|regulation of Rho protein signal transduction	cytoplasm|plasma membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|RNA binding				0		Lung NSC(167;0.0378)|all_lung(232;0.04)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.25e-51)														---	---	---	---
GFM2	84340	broad.mit.edu	37	5	74047141	74047141	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:74047141delA	uc003kdh.1	-						GFM2_uc003kdi.1_Intron|GFM2_uc010izj.1_Intron|GFM2_uc010izk.1_Intron|GFM2_uc003kdj.1_Intron|GFM2_uc010izl.1_Intron	NM_032380	NP_115756			mitochondrial elongation factor G2 isoform 1						mitochondrial translation|ribosome disassembly	mitochondrion	GTP binding|GTPase activity				0		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Breast(144;0.231)		OV - Ovarian serous cystadenocarcinoma(47;1.86e-56)														---	---	---	---
FAM169A	26049	broad.mit.edu	37	5	74135799	74135799	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:74135799delA	uc003kdm.2	-						FAM169A_uc010izm.2_Intron|FAM169A_uc003kdl.2_Intron	NM_015566	NP_056381			hypothetical protein LOC26049												0																		---	---	---	---
FAM169A	26049	broad.mit.edu	37	5	74136052	74136052	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:74136052delA	uc003kdm.2	-						FAM169A_uc010izm.2_Intron|FAM169A_uc003kdl.2_Intron	NM_015566	NP_056381			hypothetical protein LOC26049												0																		---	---	---	---
HMGCR	3156	broad.mit.edu	37	5	74651525	74651525	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:74651525delA	uc003kdp.2	+						HMGCR_uc011cst.1_Intron|HMGCR_uc003kdq.2_Intron|HMGCR_uc010izo.2_5'Flank|HMGCR_uc010izp.2_5'Flank	NM_000859	NP_000850			3-hydroxy-3-methylglutaryl-Coenzyme A reductase						cholesterol biosynthetic process|coenzyme A metabolic process|germ cell migration|gonad development|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal membrane	hydroxymethylglutaryl-CoA reductase (NADPH) activity|NADP binding			ovary(1)	1		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;2.24e-54)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Cerivastatin(DB00439)|Fluvastatin(DB01095)|Lovastatin(DB00227)|NADH(DB00157)|Pravastatin(DB00175)|Rosuvastatin(DB01098)|Simvastatin(DB00641)													---	---	---	---
COL4A3BP	10087	broad.mit.edu	37	5	74670244	74670244	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:74670244delA	uc011csu.1	-						COL4A3BP_uc003kds.2_Intron|COL4A3BP_uc003kdt.2_Intron	NM_005713	NP_005704			alpha 3 type IV collagen binding protein isoform						ER to Golgi ceramide transport|immune response	cytosol|endoplasmic reticulum membrane|Golgi apparatus	ceramide binding|phosphatidylinositol-4-phosphate binding|protein binding|protein kinase activity			skin(1)	1		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;1e-53)														---	---	---	---
SV2C	22987	broad.mit.edu	37	5	75537733	75537734	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:75537733_75537734insA	uc003kei.1	+							NM_014979	NP_055794			synaptic vesicle glycoprotein 2C						neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			skin(1)	1		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)														---	---	---	---
AGGF1	55109	broad.mit.edu	37	5	76331352	76331352	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:76331352delT	uc003ket.2	+						AGGF1_uc003kes.2_Intron|AGGF1_uc003keu.1_Intron	NM_018046	NP_060516			angiogenic factor VG5Q						angiogenesis|cell adhesion|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|RNA processing|vasculogenesis	extracellular region|perinuclear region of cytoplasm	eukaryotic cell surface binding|nucleic acid binding|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;4.51e-51)|Epithelial(54;2.2e-45)|all cancers(79;6.68e-41)														---	---	---	---
AGGF1	55109	broad.mit.edu	37	5	76348682	76348682	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:76348682delT	uc003ket.2	+							NM_018046	NP_060516			angiogenic factor VG5Q						angiogenesis|cell adhesion|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|RNA processing|vasculogenesis	extracellular region|perinuclear region of cytoplasm	eukaryotic cell surface binding|nucleic acid binding|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;4.51e-51)|Epithelial(54;2.2e-45)|all cancers(79;6.68e-41)														---	---	---	---
TBCA	6902	broad.mit.edu	37	5	76989061	76989061	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:76989061delT	uc003kfh.1	-						TBCA_uc003kfi.1_Frame_Shift_Del_p.K92fs	NM_004607	NP_004598			tubulin-specific chaperone a						'de novo' posttranslational protein folding|post-chaperonin tubulin folding pathway|tubulin complex assembly	cytoplasm|microtubule	chaperone binding|unfolded protein binding			ovary(1)	1		all_lung(232;0.000511)|Lung NSC(167;0.000601)|Ovarian(174;0.0105)|Prostate(461;0.214)		OV - Ovarian serous cystadenocarcinoma(54;1.02e-49)|Epithelial(54;1.05e-44)|all cancers(79;4.08e-40)														---	---	---	---
MTX3	345778	broad.mit.edu	37	5	79284904	79284904	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:79284904delT	uc010jag.2	-						MTX3_uc010jah.2_Intron|MTX3_uc003kge.3_Intron|MTX3_uc003kgf.1_5'Flank	NM_001010891	NP_001010891			metaxin 3						protein targeting to mitochondrion	mitochondrial outer membrane					0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.63e-45)|Epithelial(54;2.9e-40)|all cancers(79;4.68e-35)														---	---	---	---
MTX3	345778	broad.mit.edu	37	5	79285073	79285073	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:79285073delA	uc010jag.2	-						MTX3_uc010jah.2_Intron|MTX3_uc003kge.3_Intron|MTX3_uc003kgf.1_5'Flank	NM_001010891	NP_001010891			metaxin 3						protein targeting to mitochondrion	mitochondrial outer membrane					0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.63e-45)|Epithelial(54;2.9e-40)|all cancers(79;4.68e-35)														---	---	---	---
MTX3	345778	broad.mit.edu	37	5	79285899	79285899	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:79285899delA	uc010jag.2	-						MTX3_uc010jah.2_Intron|MTX3_uc003kge.3_Intron|MTX3_uc003kgf.1_5'Flank	NM_001010891	NP_001010891			metaxin 3						protein targeting to mitochondrion	mitochondrial outer membrane					0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.63e-45)|Epithelial(54;2.9e-40)|all cancers(79;4.68e-35)														---	---	---	---
FAM151B	167555	broad.mit.edu	37	5	79797492	79797493	+	Intron	DEL	TA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:79797492_79797493delTA	uc003kgv.1	+						FAM151B_uc010jal.1_Intron	NM_205548	NP_991111			hypothetical protein LOC167555												0		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;8.21e-47)|Epithelial(54;8.3e-42)|all cancers(79;1.97e-36)														---	---	---	---
RASGRF2	5924	broad.mit.edu	37	5	80419450	80419450	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:80419450delT	uc003kha.1	+						RASGRF2_uc011ctn.1_Intron	NM_006909	NP_008840			Ras protein-specific guanine						apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			breast(5)|ovary(3)|large_intestine(2)|central_nervous_system(1)|skin(1)	12		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)														---	---	---	---
Unknown	0	broad.mit.edu	37	5	82264880	82264880	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:82264880delA								ATP6AP1L (650734 upstream) : TMEM167A (83787 downstream)																																			---	---	---	---
EDIL3	10085	broad.mit.edu	37	5	83433213	83433213	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:83433213delA	uc003kio.1	-						EDIL3_uc003kip.1_Intron	NM_005711	NP_005702			EGF-like repeats and discoidin I-like						cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			skin(2)	2		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)														---	---	---	---
RASA1	5921	broad.mit.edu	37	5	86628304	86628305	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:86628304_86628305insT	uc003kiw.2	+						RASA1_uc010jav.2_Intron|RASA1_uc003kix.2_Intron|RASA1_uc011ctv.1_Intron|RASA1_uc011ctw.1_Intron|RASA1_uc010jaw.2_Intron|RASA1_uc011ctu.1_Intron	NM_002890	NP_002881			RAS p21 protein activator 1 isoform 1						cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)														---	---	---	---
CCNH	902	broad.mit.edu	37	5	86705190	86705190	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:86705190delA	uc003kjb.2	-						CCNH_uc003kiy.1_5'Flank|CCNH_uc003kiz.1_Intron|CCNH_uc003kja.2_Intron	NM_001239	NP_001230			cyclin H						G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	cyclin-dependent protein kinase activating kinase holoenzyme complex|holo TFIIH complex	protein kinase binding			ovary(2)|kidney(1)	3		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;9.01e-39)|Epithelial(54;5.08e-33)|all cancers(79;4.28e-28)									Direct_reversal_of_damage|NER					---	---	---	---
TMEM161B	153396	broad.mit.edu	37	5	87502326	87502327	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:87502326_87502327delAA	uc003kjc.2	-						TMEM161B_uc011cty.1_Intron|TMEM161B_uc010jax.2_Intron|TMEM161B_uc011ctz.1_Intron|TMEM161B_uc011ctx.1_Intron	NM_153354	NP_699185			transmembrane protein 161B							integral to membrane				skin(2)	2		all_cancers(142;0.000275)|Lung NSC(167;0.00901)|all_lung(232;0.0111)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;6.24e-36)|Epithelial(54;6.8e-31)|all cancers(79;1.07e-26)														---	---	---	---
LOC645323	645323	broad.mit.edu	37	5	87898998	87898998	+	Intron	DEL	A	-	-	rs11959094		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:87898998delA	uc011cua.1	-							NR_015436				Homo sapiens cDNA FLJ34037 fis, clone FCBBF2005439.												0																		---	---	---	---
POLR3G	10622	broad.mit.edu	37	5	89791610	89791610	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:89791610delT	uc003kjq.2	+						POLR3G_uc011cuc.1_Intron	NM_006467	NP_006458			polymerase (RNA) III (DNA directed) polypeptide						innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|regulation of transcription from RNA polymerase III promoter|response to virus	DNA-directed RNA polymerase III complex	DNA-directed RNA polymerase activity				0		all_cancers(142;5.03e-09)|all_epithelial(76;1.23e-11)|Lung NSC(167;2.46e-05)|all_lung(232;3.25e-05)|Ovarian(174;0.00832)|Colorectal(57;0.122)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(54;2.74e-31)|Epithelial(54;8.2e-26)|all cancers(79;3.86e-22)														---	---	---	---
GPR98	84059	broad.mit.edu	37	5	90086591	90086591	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:90086591delT	uc003kju.2	+						GPR98_uc003kjt.2_Intron|GPR98_uc003kjw.2_Intron	NM_032119	NP_115495			G protein-coupled receptor 98 precursor						cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)														---	---	---	---
GPR98	84059	broad.mit.edu	37	5	90327323	90327323	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:90327323delG	uc003kju.2	+						GPR98_uc003kjt.2_Intron|GPR98_uc003kjw.2_Intron|GPR98_uc003kjx.2_Intron	NM_032119	NP_115495			G protein-coupled receptor 98 precursor						cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)														---	---	---	---
FAM172A	83989	broad.mit.edu	37	5	93019526	93019526	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:93019526delT	uc010jbd.2	-						FAM172A_uc011cuf.1_Intron|FAM172A_uc011cug.1_Intron|FAM172A_uc011cuh.1_Intron|FAM172A_uc011cui.1_Intron|FAM172A_uc011cuj.1_Intron	NM_032042	NP_114431			hypothetical protein LOC83989 isoform 1							endoplasmic reticulum|extracellular region					0																		---	---	---	---
ANKRD32	84250	broad.mit.edu	37	5	94030769	94030769	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:94030769delA	uc003kkr.3	+	21	3009	c.2929delA	c.(2929-2931)ATTfs	p.I977fs	ANKRD32_uc003kks.2_Frame_Shift_Del_p.I341fs	NM_032290	NP_115666	Q9BQI6	ANR32_HUMAN	ankyrin repeat domain 32	977										ovary(2)	2		all_cancers(142;1.51e-09)|all_epithelial(76;4.68e-12)|all_lung(232;5.94e-05)|Ovarian(174;0.000953)|Lung NSC(167;0.00105)|Colorectal(57;0.122)|Lung SC(612;0.152)		all cancers(79;3.88e-18)														---	---	---	---
TTC37	9652	broad.mit.edu	37	5	94800222	94800222	+	3'UTR	DEL	A	-	-	rs9885158	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:94800222delA	uc003klb.2	-	43						NM_014639	NP_055454			tetratricopeptide repeat domain 37								binding			ovary(3)|pancreas(1)	4																		---	---	---	---
TTC37	9652	broad.mit.edu	37	5	94826831	94826831	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:94826831delA	uc003klb.2	-							NM_014639	NP_055454			tetratricopeptide repeat domain 37								binding			ovary(3)|pancreas(1)	4																		---	---	---	---
RHOBTB3	22836	broad.mit.edu	37	5	95067839	95067839	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:95067839delT	uc003klm.2	+						RHOBTB3_uc003klk.1_Intron|RHOBTB3_uc003kll.2_Frame_Shift_Del_p.P93fs	NM_014899	NP_055714			rho-related BTB domain containing 3						retrograde transport, endosome to Golgi	Golgi apparatus	ATP binding|ATPase activity|Rab GTPase binding			lung(1)|skin(1)	2		all_cancers(142;2.58e-06)|all_epithelial(76;4.19e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0164)|Colorectal(57;0.0846)|Breast(839;0.198)		all cancers(79;8.79e-16)														---	---	---	---
Unknown	0	broad.mit.edu	37	5	95170396	95170402	+	IGR	DEL	TTTTTTC	-	-	rs56126846	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:95170396_95170402delTTTTTTC								GLRX (11819 upstream) : C5orf27 (17534 downstream)																																			---	---	---	---
CHD1	1105	broad.mit.edu	37	5	98217655	98217655	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:98217655delT	uc003knf.2	-							NM_001270	NP_001261			chromodomain helicase DNA binding protein 1						regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			lung(2)|ovary(1)|breast(1)|pancreas(1)	5		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)													---	---	---	---
CHD1	1105	broad.mit.edu	37	5	98232157	98232157	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:98232157delA	uc003knf.2	-							NM_001270	NP_001261			chromodomain helicase DNA binding protein 1						regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			lung(2)|ovary(1)|breast(1)|pancreas(1)	5		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)													---	---	---	---
SLCO6A1	133482	broad.mit.edu	37	5	101755728	101755728	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:101755728delA	uc003knn.2	-						SLCO6A1_uc003kno.2_Intron|SLCO6A1_uc003knp.2_Intron|SLCO6A1_uc003knq.2_Intron	NM_173488	NP_775759			solute carrier organic anion transporter family,							integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)														---	---	---	---
PPIP5K2	23262	broad.mit.edu	37	5	102494288	102494288	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:102494288delT	uc003kod.3	+						PPIP5K2_uc011cva.1_Intron|PPIP5K2_uc003koe.2_Intron	NM_015216	NP_056031			Histidine acid phosphatase domain containing 1						inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			ovary(1)|skin(1)	2																		---	---	---	---
PPIP5K2	23262	broad.mit.edu	37	5	102508800	102508800	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:102508800delT	uc003kod.3	+						PPIP5K2_uc011cva.1_Intron|PPIP5K2_uc003koe.2_Intron|PPIP5K2_uc003kof.2_Intron	NM_015216	NP_056031			Histidine acid phosphatase domain containing 1						inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			ovary(1)|skin(1)	2																		---	---	---	---
C5orf30	90355	broad.mit.edu	37	5	102612419	102612419	+	3'UTR	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:102612419delG	uc003kog.1	+	3					C5orf30_uc003koh.1_3'UTR	NM_033211	NP_149988			hypothetical protein LOC90355												0		all_cancers(142;2.22e-05)|all_epithelial(76;9.54e-08)|Prostate(80;0.0174)|Colorectal(57;0.0551)|Ovarian(225;0.11)|Lung NSC(167;0.136)|all_lung(232;0.18)		Epithelial(69;2.84e-14)|COAD - Colon adenocarcinoma(37;0.00762)														---	---	---	---
FER	2241	broad.mit.edu	37	5	108121299	108121299	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:108121299delA	uc003kop.1	+						FER_uc011cve.1_Intron|FER_uc011cvf.1_Intron|FER_uc003koq.2_Intron|FER_uc011cvg.1_Intron	NM_005246	NP_005237			fer (fps/fes related) tyrosine kinase						intracellular signal transduction|peptidyl-tyrosine phosphorylation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|kidney(1)	5		all_cancers(142;2.86e-06)|all_epithelial(76;9.81e-08)|Prostate(80;0.00972)|Lung NSC(167;0.039)|Ovarian(225;0.0448)|all_lung(232;0.0496)|Colorectal(57;0.0986)|Breast(839;0.152)		OV - Ovarian serous cystadenocarcinoma(64;6.77e-10)|Epithelial(69;4.13e-08)|COAD - Colon adenocarcinoma(37;0.0174)														---	---	---	---
APC	324	broad.mit.edu	37	5	112164806	112164806	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:112164806delT	uc010jby.2	+						APC_uc011cvt.1_Intron|APC_uc003kpz.3_Intron|APC_uc003kpy.3_Intron|APC_uc010jbz.2_Intron|APC_uc010jca.2_Intron	NM_001127511	NP_001120983			adenomatous polyposis coli						canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)			12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			---	---	---	---
DCP2	167227	broad.mit.edu	37	5	112343574	112343574	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:112343574delT	uc003kqh.2	+						DCP2_uc011cwa.1_Intron|DCP2_uc010jcc.2_Intron	NM_152624	NP_689837			DCP2 decapping enzyme						exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasmic mRNA processing body|cytosol|nucleus|RNA-induced silencing complex	exoribonuclease activity, producing 5'-phosphomonoesters|manganese ion binding|protein binding|protein binding|RNA binding				0		all_cancers(142;4.41e-05)|all_epithelial(76;3.65e-07)|Colorectal(10;0.00115)|Prostate(80;0.00133)|Ovarian(225;0.0443)		OV - Ovarian serous cystadenocarcinoma(64;6.98e-08)|Epithelial(69;7.87e-08)|all cancers(49;1.06e-05)|COAD - Colon adenocarcinoma(37;0.0123)|Colorectal(14;0.0171)														---	---	---	---
CDO1	1036	broad.mit.edu	37	5	115148745	115148757	+	Intron	DEL	AAAAAAAAAAAAA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:115148745_115148757delAAAAAAAAAAAAA	uc003krg.2	-							NM_001801	NP_001792			cysteine dioxygenase						inflammatory response|sulfur amino acid biosynthetic process|taurine biosynthetic process	cytosol	cysteine dioxygenase activity			large_intestine(1)|skin(1)	2		all_cancers(142;0.0046)|all_epithelial(76;0.000161)|Prostate(80;0.0132)|Ovarian(225;0.0776)		OV - Ovarian serous cystadenocarcinoma(64;7.8e-08)|Epithelial(69;7.32e-07)|all cancers(49;3.24e-05)	L-Cysteine(DB00151)|NADH(DB00157)													---	---	---	---
DTWD2	285605	broad.mit.edu	37	5	118310422	118310422	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:118310422delT	uc003ksa.2	-							NM_173666	NP_775937			DTW domain containing 2												0		all_epithelial(76;0.0982)|Prostate(80;0.121)		OV - Ovarian serous cystadenocarcinoma(64;0.000228)|Epithelial(69;0.000941)|all cancers(49;0.00939)														---	---	---	---
DMXL1	1657	broad.mit.edu	37	5	118510897	118510897	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:118510897delA	uc003ksd.2	+						DMXL1_uc010jcl.1_Intron	NM_005509	NP_005500			Dmx-like 1											ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)														---	---	---	---
DMXL1	1657	broad.mit.edu	37	5	118513038	118513038	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:118513038delT	uc003ksd.2	+						DMXL1_uc010jcl.1_Intron	NM_005509	NP_005500			Dmx-like 1											ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)														---	---	---	---
Unknown	0	broad.mit.edu	37	5	120952552	120952552	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:120952552delA								PRR16 (929590 upstream) : FTMT (235098 downstream)																																			---	---	---	---
SNCAIP	9627	broad.mit.edu	37	5	121776153	121776156	+	Intron	DEL	TCAG	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:121776153_121776156delTCAG	uc003ksw.1	+						SNCAIP_uc011cwl.1_Splice_Site|SNCAIP_uc010jct.2_Intron|SNCAIP_uc003ksx.1_Intron|SNCAIP_uc003ksy.1_Intron|SNCAIP_uc003ksz.1_Intron|SNCAIP_uc010jcu.2_Intron|SNCAIP_uc011cwm.1_Intron|SNCAIP_uc003kta.1_Intron|SNCAIP_uc010jcv.1_Intron|SNCAIP_uc010jcw.1_Intron|SNCAIP_uc010jcx.1_Intron|uc003ktb.1_Intron	NM_005460	NP_005451			synuclein alpha interacting protein						cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)														---	---	---	---
SNX2	6643	broad.mit.edu	37	5	122163031	122163031	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:122163031delT	uc003kte.2	+						SNX2_uc011cwn.1_Intron	NM_003100	NP_003091			sorting nexin 2						cell communication|endocytosis|intracellular protein transport	early endosome membrane	phosphatidylinositol binding|protein binding|protein transporter activity			kidney(1)	1		all_cancers(142;1.14e-44)|all_lung(232;1.03e-13)|Lung NSC(810;2.5e-13)|Breast(839;0.000812)|Myeloproliferative disorder(839;0.0122)|Prostate(80;0.0235)|all_hematologic(541;0.0592)|all_neural(839;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	all cancers(49;2.13e-24)|Epithelial(69;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(64;5.6e-11)|BRCA - Breast invasive adenocarcinoma(61;0.00013)|GBM - Glioblastoma multiforme(465;0.000357)|COAD - Colon adenocarcinoma(49;0.000887)|Lung(113;0.0109)														---	---	---	---
CSNK1G3	1456	broad.mit.edu	37	5	122924299	122924299	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:122924299delA	uc003ktm.2	+						CSNK1G3_uc003ktl.2_Intron|CSNK1G3_uc003ktn.2_Intron|CSNK1G3_uc003kto.2_Intron|CSNK1G3_uc011cwr.1_Intron|CSNK1G3_uc011cws.1_Intron|CSNK1G3_uc010jda.2_Intron	NM_004384	NP_004375			casein kinase 1, gamma 3 isoform 1						Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity				0		all_cancers(142;0.0156)|Prostate(80;0.0322)|Lung NSC(810;0.245)	KIRC - Kidney renal clear cell carcinoma(527;0.165)|Kidney(363;0.229)	OV - Ovarian serous cystadenocarcinoma(64;0.000121)|Epithelial(69;0.000227)|all cancers(49;0.00176)														---	---	---	---
CSNK1G3	1456	broad.mit.edu	37	5	122940402	122940402	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:122940402delT	uc003ktm.2	+						CSNK1G3_uc003ktl.2_Intron|CSNK1G3_uc003ktn.2_Intron|CSNK1G3_uc003kto.2_Intron|CSNK1G3_uc011cwr.1_Intron|CSNK1G3_uc011cws.1_Intron|CSNK1G3_uc010jda.2_Intron	NM_004384	NP_004375			casein kinase 1, gamma 3 isoform 1						Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity				0		all_cancers(142;0.0156)|Prostate(80;0.0322)|Lung NSC(810;0.245)	KIRC - Kidney renal clear cell carcinoma(527;0.165)|Kidney(363;0.229)	OV - Ovarian serous cystadenocarcinoma(64;0.000121)|Epithelial(69;0.000227)|all cancers(49;0.00176)														---	---	---	---
Unknown	0	broad.mit.edu	37	5	122973202	122973202	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:122973202delA								CSNK1G3 (20740 upstream) : ZNF608 (999408 downstream)																																			---	---	---	---
PRRC1	133619	broad.mit.edu	37	5	126866120	126866120	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:126866120delT	uc003kuk.2	+						PRRC1_uc003kuj.3_Intron	NM_130809	NP_570721			proline-rich coiled-coil 1							Golgi apparatus					0		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0851)|Epithelial(69;0.113)														---	---	---	---
ISOC1	51015	broad.mit.edu	37	5	128440485	128440485	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:128440485delT	uc003kva.2	+							NM_016048	NP_057132			isochorismatase domain containing 1							peroxisome	catalytic activity				0		all_cancers(142;0.0813)|Prostate(80;0.0865)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.138)|OV - Ovarian serous cystadenocarcinoma(64;0.164)														---	---	---	---
LYRM7	90624	broad.mit.edu	37	5	130515638	130515638	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:130515638delT	uc003kvg.1	+							NM_181705	NP_859056			Lyrm7 homolog												0		all_cancers(142;0.0377)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)															---	---	---	---
RAPGEF6	51735	broad.mit.edu	37	5	130764956	130764956	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:130764956delA	uc003kvn.1	-						RAPGEF6_uc003kvp.1_Intron|RAPGEF6_uc003kvo.1_Intron|RAPGEF6_uc010jdi.1_Intron|RAPGEF6_uc010jdj.1_Intron|RAPGEF6_uc003kvm.1_Intron	NM_016340	NP_057424			PDZ domain-containing guanine nucleotide						Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			ovary(1)|lung(1)|central_nervous_system(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)														---	---	---	---
RAPGEF6	51735	broad.mit.edu	37	5	130897900	130897900	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:130897900delA	uc003kvn.1	-						RAPGEF6_uc003kvp.1_Intron|RAPGEF6_uc003kvo.1_Intron|RAPGEF6_uc010jdi.1_Intron|RAPGEF6_uc010jdj.1_Intron|RAPGEF6_uc003kvr.2_Intron|RAPGEF6_uc011cxe.1_Intron|RAPGEF6_uc010jdk.2_Intron	NM_016340	NP_057424			PDZ domain-containing guanine nucleotide						Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			ovary(1)|lung(1)|central_nervous_system(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)														---	---	---	---
ACSL6	23305	broad.mit.edu	37	5	131324203	131324203	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:131324203delC	uc010jdo.1	-						ACSL6_uc003kvv.1_Intron|ACSL6_uc003kvx.1_Intron|ACSL6_uc003kvy.1_Intron|ACSL6_uc003kwb.2_Intron|ACSL6_uc003kvz.1_Intron|ACSL6_uc003kwa.1_Intron|ACSL6_uc010jdn.1_Intron|ACSL6_uc010jdp.1_5'Flank	NM_015256	NP_056071			acyl-CoA synthetase long-chain family member 6						fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane|plasma membrane	ATP binding|long-chain fatty acid-CoA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(142;0.107)|Breast(839;0.198)|Lung NSC(810;0.216)|all_lung(232;0.248)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)															---	---	---	---
SLC22A4	6583	broad.mit.edu	37	5	131676126	131676126	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:131676126delT	uc003kwq.2	+						uc003kwr.3_Intron	NM_003059	NP_003050			solute carrier family 22 member 4						body fluid secretion|sodium ion transport	apical plasma membrane|integral to plasma membrane|mitochondrion	ATP binding|carnitine transporter activity|cation:cation antiporter activity|PDZ domain binding|secondary active organic cation transmembrane transporter activity|symporter activity				0		all_cancers(142;0.0752)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)													---	---	---	---
HSPA4	3308	broad.mit.edu	37	5	132406269	132406269	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:132406269delT	uc003kyj.2	+							NM_002154	NP_002145			heat shock 70kDa protein 4						cellular chaperone-mediated protein complex assembly|protein import into mitochondrial outer membrane|response to unfolded protein	cytoplasm|nucleus	ATP binding			lung(1)|breast(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)															---	---	---	---
SEC24A	10802	broad.mit.edu	37	5	134033899	134033899	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:134033899delA	uc003kzs.2	+						SEC24A_uc011cxu.1_Intron	NM_021982	NP_068817			SEC24 related gene family, member A						COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)															---	---	---	---
SEC24A	10802	broad.mit.edu	37	5	134039635	134039635	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:134039635delT	uc003kzs.2	+						SEC24A_uc011cxu.1_Intron	NM_021982	NP_068817			SEC24 related gene family, member A						COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)															---	---	---	---
DDX46	9879	broad.mit.edu	37	5	134164508	134164508	+	3'UTR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:134164508delT	uc003kzw.2	+	23						NM_014829	NP_055644			DEAD (Asp-Glu-Ala-Asp) box polypeptide 46						mRNA processing|RNA splicing	Cajal body|nuclear speck	ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)															---	---	---	---
SPOCK1	6695	broad.mit.edu	37	5	136476248	136476248	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:136476248delC	uc003lbo.2	-						SPOCK1_uc003lbp.2_Intron	NM_004598	NP_004589			sparc/osteonectin, cwcv and kazal-like domains						cell adhesion|cell proliferation|cellular component movement|nervous system development|signal transduction	proteinaceous extracellular matrix	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)															---	---	---	---
KLHL3	26249	broad.mit.edu	37	5	136972883	136972883	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:136972883delA	uc010jek.2	-						KLHL3_uc011cyc.1_Intron|KLHL3_uc003lbr.3_Intron|KLHL3_uc011cyd.1_Intron|KLHL3_uc010jel.1_Intron	NM_017415	NP_059111			kelch-like 3							cytoplasm|cytoskeleton	actin binding|structural molecule activity				0		all_hematologic(541;3.67e-07)|Breast(839;7.61e-05)|Prostate(281;0.000825)|Ovarian(839;0.0481)|all_lung(232;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	GBM - Glioblastoma multiforme(465;0.0223)														---	---	---	---
PKD2L2	27039	broad.mit.edu	37	5	137235106	137235106	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:137235106delA	uc003lby.2	+						PKD2L2_uc010jep.1_Intron|PKD2L2_uc003lbw.1_Intron|PKD2L2_uc003lbx.2_Intron|PKD2L2_uc011cyi.1_5'Flank	NM_014386	NP_055201			polycystic kidney disease 2-like 2							integral to membrane	calcium ion binding|ion channel activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)															---	---	---	---
NME5	8382	broad.mit.edu	37	5	137464066	137464066	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:137464066delA	uc003lce.2	-						BRD8_uc003lcc.1_Intron	NM_003551	NP_003542			non-metastatic cells 5, protein expressed in						anti-apoptosis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatid development|UTP biosynthetic process		ATP binding|nucleoside diphosphate kinase activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)															---	---	---	---
MATR3	9782	broad.mit.edu	37	5	138654927	138654928	+	Intron	DEL	TA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:138654927_138654928delTA	uc003ldu.2	+						MATR3_uc010jfb.2_Intron|MATR3_uc003ldt.2_Intron|MATR3_uc003ldw.2_Intron|MATR3_uc003ldx.2_Intron|MATR3_uc010jfc.2_Intron|MATR3_uc003ldy.2_Intron|MATR3_uc011czb.1_Intron|MATR3_uc003ldz.2_Intron|MATR3_uc003lea.2_Intron|MATR3_uc003leb.2_Intron|MATR3_uc003lec.2_Intron	NM_199189	NP_954659			matrin 3							nuclear inner membrane|nuclear matrix	nucleotide binding|protein binding|RNA binding|structural molecule activity|zinc ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)															---	---	---	---
HBEGF	1839	broad.mit.edu	37	5	139725314	139725315	+	Intron	DEL	AG	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:139725314_139725315delAG	uc003lfi.2	-						HBEGF_uc010jfj.2_Intron	NM_001945	NP_001936			heparin-binding EGF-like growth factor						epidermal growth factor receptor signaling pathway|muscle organ development|positive regulation of protein kinase B signaling cascade|positive regulation of wound healing	cell surface|extracellular space|integral to plasma membrane	epidermal growth factor receptor binding|eukaryotic cell surface binding|growth factor activity|heparin binding|receptor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)													OREG0016844	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	5	139838167	139838167	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:139838167delA	uc003lfs.1	+						ANKHD1_uc003lfq.1_Intron|ANKHD1_uc003lfr.2_Intron|ANKHD1_uc003lft.1_5'Flank|ANKHD1_uc003lfu.1_5'Flank|ANKHD1_uc003lfp.2_Intron|ANKHD1_uc003lfo.2_Intron|ANKHD1_uc010jfk.2_Intron	NM_020690	NP_065741			ANKHD1-EIF4EBP3 protein							cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
KIAA0141	9812	broad.mit.edu	37	5	141312717	141312717	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:141312717delA	uc003lls.2	+						KIAA0141_uc003llt.2_Intron|KIAA0141_uc003llu.1_5'Flank	NM_001142603	NP_001136075			hypothetical protein LOC9812 precursor						apoptosis|regulation of caspase activity	mitochondrion	protein binding			skin(1)	1		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
RBM27	54439	broad.mit.edu	37	5	145640215	145640215	+	Intron	DEL	A	-	-	rs2304032	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:145640215delA	uc003lnz.3	+						RBM27_uc003lny.2_Intron	NM_018989	NP_061862			RNA binding motif protein 27						mRNA processing	cytoplasm|nuclear speck	nucleotide binding|RNA binding|zinc ion binding			central_nervous_system(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)															---	---	---	---
RBM27	54439	broad.mit.edu	37	5	145647476	145647476	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:145647476delA	uc003lnz.3	+						RBM27_uc003lny.2_Intron	NM_018989	NP_061862			RNA binding motif protein 27						mRNA processing	cytoplasm|nuclear speck	nucleotide binding|RNA binding|zinc ion binding			central_nervous_system(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)															---	---	---	---
TCERG1	10915	broad.mit.edu	37	5	145883505	145883506	+	Frame_Shift_Del	DEL	GA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:145883505_145883506delGA	uc003lob.2	+	18	2706_2707	c.2666_2667delGA	c.(2665-2667)CGAfs	p.R889fs	TCERG1_uc003loc.2_Frame_Shift_Del_p.R868fs	NM_006706	NP_006697	O14776	TCRG1_HUMAN	transcription elongation regulator 1 isoform 1	889	Potential.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			ovary(1)|skin(1)	2		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)															---	---	---	---
TCERG1	10915	broad.mit.edu	37	5	145889882	145889889	+	Intron	DEL	AAAAAAAA	-	-	rs67804115		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:145889882_145889889delAAAAAAAA	uc003lob.2	+						TCERG1_uc003loc.2_Intron	NM_006706	NP_006697			transcription elongation regulator 1 isoform 1						regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			ovary(1)|skin(1)	2		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)															---	---	---	---
PPP2R2B	5521	broad.mit.edu	37	5	145969949	145969949	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:145969949delT	uc003loe.2	-						PPP2R2B_uc010jgm.2_Intron|PPP2R2B_uc003log.3_Intron|PPP2R2B_uc003lof.3_Intron|PPP2R2B_uc003loi.3_Intron|PPP2R2B_uc003loh.3_Intron|PPP2R2B_uc003loj.3_Intron|PPP2R2B_uc003lok.3_Intron|PPP2R2B_uc011dbu.1_Intron|PPP2R2B_uc011dbv.1_Intron	NM_004576	NP_004567			beta isoform of regulatory subunit B55, protein						apoptosis|signal transduction	cytoskeleton|mitochondrial outer membrane|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(1)|prostate(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)															---	---	---	---
FBXO38	81545	broad.mit.edu	37	5	147795390	147795390	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:147795390delA	uc003lpf.1	+						FBXO38_uc003lpg.1_Intron|FBXO38_uc003lph.2_Intron	NM_205836	NP_995308			F-box protein 38 isoform b							cytoplasm|nucleus				ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
FBXO38	81545	broad.mit.edu	37	5	147805074	147805074	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:147805074delT	uc003lpf.1	+						FBXO38_uc003lpg.1_Intron|FBXO38_uc003lph.2_Intron	NM_205836	NP_995308			F-box protein 38 isoform b							cytoplasm|nucleus				ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
CSF1R	1436	broad.mit.edu	37	5	149447716	149447716	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:149447716delG	uc003lrl.2	-						CSF1R_uc011dcd.1_Intron|CSF1R_uc010jhc.2_Intron|CSF1R_uc003lrm.2_Intron	NM_005211	NP_005202			colony stimulating factor 1 receptor precursor						cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			haematopoietic_and_lymphoid_tissue(38)|lung(6)|central_nervous_system(3)|liver(3)|breast(2)|endometrium(1)|ovary(1)	54			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)													---	---	---	---
DCTN4	51164	broad.mit.edu	37	5	150102363	150102364	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:150102363_150102364delTT	uc003lsv.2	-						DCTN4_uc003lsu.2_Intron|DCTN4_uc010jhi.2_Intron	NM_016221	NP_057305			dynactin 4 (p62) isoform b							centrosome|nucleus	protein N-terminus binding			central_nervous_system(1)	1		Medulloblastoma(196;0.167)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)															---	---	---	---
GRIA1	2890	broad.mit.edu	37	5	153175021	153175021	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:153175021delC	uc003lva.3	+						GRIA1_uc003luy.3_Intron|GRIA1_uc003luz.3_Intron|GRIA1_uc011dcv.1_Intron|GRIA1_uc011dcw.1_Intron|GRIA1_uc011dcx.1_Intron|GRIA1_uc011dcy.1_Intron|GRIA1_uc011dcz.1_Intron	NM_001114183	NP_001107655			glutamate receptor, ionotropic, AMPA 1 isoform						synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)													---	---	---	---
GALNT10	55568	broad.mit.edu	37	5	153674402	153674403	+	Frame_Shift_Ins	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:153674402_153674403insT	uc003lvh.2	+	2	318_319	c.186_187insT	c.(184-189)ACGTTTfs	p.T62fs	GALNT10_uc003lvg.1_Frame_Shift_Ins_p.T62fs|GALNT10_uc010jic.2_RNA	NM_198321	NP_938080	Q86SR1	GLT10_HUMAN	GalNAc transferase 10 isoform a	62_63	Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)|all_hematologic(541;0.21)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)															---	---	---	---
GEMIN5	25929	broad.mit.edu	37	5	154275432	154275432	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:154275432delA	uc003lvx.3	-						GEMIN5_uc011ddk.1_Intron	NM_015465	NP_056280			gemin 5						ncRNA metabolic process|protein complex assembly|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding|snRNA binding			skin(2)|ovary(1)	3	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)															---	---	---	---
GEMIN5	25929	broad.mit.edu	37	5	154282754	154282754	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:154282754delA	uc003lvx.3	-						GEMIN5_uc011ddk.1_Intron	NM_015465	NP_056280			gemin 5						ncRNA metabolic process|protein complex assembly|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding|snRNA binding			skin(2)|ovary(1)	3	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)															---	---	---	---
TIMD4	91937	broad.mit.edu	37	5	156375404	156375404	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:156375404delA	uc003lwh.2	-						TIMD4_uc010jii.2_Intron	NM_138379	NP_612388			T-cell immunoglobulin and mucin domain							integral to membrane				ovary(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)															---	---	---	---
UBLCP1	134510	broad.mit.edu	37	5	158712091	158712091	+	3'UTR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:158712091delT	uc003lxq.2	+	11						NM_145049	NP_659486			ubiquitin-like domain containing CTD phosphatase							nucleus	phosphoprotein phosphatase activity			ovary(1)	1	Renal(175;0.00196)	Medulloblastoma(196;0.0523)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)															---	---	---	---
HMMR	3161	broad.mit.edu	37	5	162902738	162902738	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:162902738delT	uc003lzf.2	+						HMMR_uc003lzh.2_Intron|HMMR_uc003lzg.2_Intron|HMMR_uc011dem.1_Intron	NM_012484	NP_036616			hyaluronan-mediated motility receptor isoform b							cell surface|cytoplasm	hyaluronic acid binding				0	Renal(175;0.000281)	Medulloblastoma(196;0.00853)|all_neural(177;0.0408)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0296)|OV - Ovarian serous cystadenocarcinoma(192;0.0423)|Epithelial(171;0.0848)														---	---	---	---
HMMR	3161	broad.mit.edu	37	5	162917426	162917426	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:162917426delA	uc003lzf.2	+	17	2172	c.1990delA	c.(1990-1992)AAAfs	p.K664fs	HMMR_uc003lzh.2_Frame_Shift_Del_p.K665fs|HMMR_uc003lzg.2_Frame_Shift_Del_p.K649fs|HMMR_uc011dem.1_Frame_Shift_Del_p.K578fs|uc003lzi.2_Intron	NM_012484	NP_036616	O75330	HMMR_HUMAN	hyaluronan-mediated motility receptor isoform b	664	Hyaluronic acid-binding (Potential).					cell surface|cytoplasm	hyaluronic acid binding				0	Renal(175;0.000281)	Medulloblastoma(196;0.00853)|all_neural(177;0.0408)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0296)|OV - Ovarian serous cystadenocarcinoma(192;0.0423)|Epithelial(171;0.0848)														---	---	---	---
SLIT3	6586	broad.mit.edu	37	5	168119505	168119506	+	Intron	DEL	GA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:168119505_168119506delGA	uc003mab.2	-						SLIT3_uc010jjg.2_Intron	NM_003062	NP_003053			slit homolog 3 precursor						apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)															---	---	---	---
SFXN1	94081	broad.mit.edu	37	5	174949356	174949356	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:174949356delT	uc003mda.2	+						SFXN1_uc003mdb.1_Intron	NM_022754	NP_073591			sideroflexin 1						iron ion homeostasis	integral to membrane	cation transmembrane transporter activity|protein binding			ovary(1)	1	all_cancers(89;0.00922)|Renal(175;0.000269)|Lung NSC(126;0.00515)|all_lung(126;0.00873)	Medulloblastoma(196;0.0399)|all_neural(177;0.0663)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)															---	---	---	---
UNC5A	90249	broad.mit.edu	37	5	176305780	176305780	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:176305780delC	uc003mey.2	+							NM_133369	NP_588610			netrin receptor Unc5h1 precursor						apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				skin(1)	1	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)															---	---	---	---
NSD1	64324	broad.mit.edu	37	5	176673750	176673750	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:176673750delA	uc003mfr.3	+	10	4588	c.4450delA	c.(4450-4452)AAAfs	p.K1484fs	NSD1_uc003mft.3_Frame_Shift_Del_p.K1215fs|NSD1_uc003mfs.1_Frame_Shift_Del_p.K1381fs|NSD1_uc011dfx.1_Frame_Shift_Del_p.K1132fs	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1484					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)				T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			---	---	---	---
DBN1	1627	broad.mit.edu	37	5	176885163	176885163	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:176885163delG	uc003mgy.2	-	12	1844	c.1672delC	c.(1672-1674)CAGfs	p.Q558fs	DBN1_uc011dga.1_Frame_Shift_Del_p.Q290fs|DBN1_uc003mgx.2_Frame_Shift_Del_p.Q560fs|DBN1_uc010jkn.1_Frame_Shift_Del_p.Q508fs|DBN1_uc003mgz.1_Frame_Shift_Del_p.Q541fs	NM_004395	NP_004386	Q16643	DREB_HUMAN	drebrin 1 isoform a	558					actin filament organization|regulation of dendrite development|regulation of neuronal synaptic plasticity	actomyosin|cytoplasm|dendrite	actin binding|profilin binding			breast(3)|ovary(1)|lung(1)|skin(1)	6	all_cancers(89;2.17e-05)|Renal(175;0.000269)|Lung NSC(126;0.0014)|all_lung(126;0.0025)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)															---	---	---	---
DDX41	51428	broad.mit.edu	37	5	176942393	176942393	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:176942393delA	uc003mho.2	-						DDX41_uc003mhm.2_5'UTR|DDX41_uc003mhn.2_Intron|DDX41_uc003mhp.2_Intron|DDX41_uc003mhq.1_5'UTR	NM_016222	NP_057306			DEAD-box protein abstrakt						apoptosis|multicellular organismal development	catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|zinc ion binding				0	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.191)															---	---	---	---
CNOT6	57472	broad.mit.edu	37	5	179994114	179994114	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:179994114delT	uc003mlx.2	+	8	1093	c.744delT	c.(742-744)AGTfs	p.S248fs	CNOT6_uc010jld.2_Frame_Shift_Del_p.S248fs|CNOT6_uc010jle.2_Frame_Shift_Del_p.S243fs	NM_015455	NP_056270	Q9ULM6	CNOT6_HUMAN	CCR4-NOT transcription complex, subunit 6	248					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	exonuclease activity|metal ion binding|protein binding|RNA binding				0	all_cancers(89;3.3e-05)|all_epithelial(37;7.38e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00543)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.023)														---	---	---	---
FLT4	2324	broad.mit.edu	37	5	180049928	180049928	+	Intron	DEL	A	-	-	rs307828		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:180049928delA	uc003mma.3	-						FLT4_uc003mlz.3_Intron|FLT4_uc003mmb.1_Intron|FLT4_uc011dgy.1_Intron	NM_002020	NP_002011			fms-related tyrosine kinase 4 isoform 2						positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)									Congenital_Hereditary_Lymphedema				---	---	---	---
Unknown	0	broad.mit.edu	37	5	180165983	180165984	+	IGR	INS	-	C	C	rs2054696	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:180165983_180165984insC								FLT4 (89359 upstream) : OR2Y1 (139 downstream)																																			---	---	---	---
RIPK1	8737	broad.mit.edu	37	6	3081034	3081034	+	Intron	DEL	C	-	-	rs3830793		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:3081034delC	uc010jni.2	+						RIPK1_uc003muv.3_Intron|RIPK1_uc003muw.3_Intron|RIPK1_uc011dhs.1_Intron|RIPK1_uc003mux.2_Intron	NM_003804	NP_003795			receptor (TNFRSF)-interacting serine-threonine						activation of caspase activity|activation of JUN kinase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|induction of necroptosis by extracellular signals|innate immune response|MyD88-independent toll-like receptor signaling pathway|positive regulation of anti-apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|protein autophosphorylation|regulation of ATP:ADP antiporter activity|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|death-inducing signaling complex|endosome membrane|mitochondrion|receptor complex	ATP binding|death domain binding|death receptor binding|protein serine/threonine kinase activity			large_intestine(3)|lung(1)|skin(1)	5	Ovarian(93;0.0386)	all_hematologic(90;0.0895)																---	---	---	---
PRPF4B	8899	broad.mit.edu	37	6	4052930	4052931	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:4052930_4052931insT	uc003mvv.2	+						PRPF4B_uc003mvw.2_Intron|C6orf146_uc010jnq.1_Intron|PRPF4B_uc011dhv.1_Intron	NM_003913	NP_003904			serine/threonine-protein kinase PRP4K							catalytic step 2 spliceosome	ATP binding|protein binding|protein serine/threonine kinase activity			breast(5)	5	Ovarian(93;0.0925)	all_hematologic(90;0.0895)																---	---	---	---
DSP	1832	broad.mit.edu	37	6	7569358	7569358	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:7569358delA	uc003mxp.1	+						DSP_uc003mxq.1_Intron	NM_004415	NP_004406			desmoplakin isoform I						cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)														---	---	---	---
DSP	1832	broad.mit.edu	37	6	7572364	7572364	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:7572364delA	uc003mxp.1	+						DSP_uc003mxq.1_Intron	NM_004415	NP_004406			desmoplakin isoform I						cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)														---	---	---	---
BMP6	654	broad.mit.edu	37	6	7880637	7880638	+	3'UTR	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:7880637_7880638delAA	uc003mxu.3	+	7						NM_001718	NP_001709			bone morphogenetic protein 6 preproprotein						BMP signaling pathway|cartilage development|growth|immune response|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	BMP receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity			large_intestine(2)|ovary(1)	3	Ovarian(93;0.0721)																	---	---	---	---
SLC35B3	51000	broad.mit.edu	37	6	8434774	8434774	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:8434774delT	uc010joe.2	-						uc003mye.2_5'Flank|SLC35B3_uc003myc.2_Intron|SLC35B3_uc003myb.2_Intron|SLC35B3_uc011did.1_Intron|SLC35B3_uc003myd.2_Intron|SLC35B3_uc010jof.2_Intron|SLC35B3_uc011die.1_Intron	NM_001142541	NP_001136013			solute carrier family 35, member B3						transmembrane transport	Golgi membrane|integral to membrane					0	Ovarian(93;0.0569)																	---	---	---	---
TMEM14B	81853	broad.mit.edu	37	6	10756864	10756864	+	3'UTR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:10756864delA	uc003mzk.3	+	6					SYCP2L_uc011dim.1_Intron|TMEM14B_uc010jor.2_3'UTR|TMEM14B_uc010jos.1_Intron	NM_030969	NP_112231			transmembrane protein 14B isoform a							integral to membrane					0	Ovarian(93;0.107)|Breast(50;0.137)	all_hematologic(90;0.135)																---	---	---	---
PHACTR1	221692	broad.mit.edu	37	6	13286469	13286469	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:13286469delT	uc010jpc.2	+						PHACTR1_uc003nah.1_Intron|TBC1D7_uc003naj.2_Intron|TBC1D7_uc011dis.1_Intron|uc003nak.1_Intron	NM_030948	NP_112210			phosphatase and actin regulator 1							cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity				0	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)															---	---	---	---
GFOD1	54438	broad.mit.edu	37	6	13391013	13391016	+	Intron	DEL	AAGG	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:13391013_13391016delAAGG	uc003nat.1	-						GFOD1_uc003nas.1_Intron	NM_018988	NP_061861			glucose-fructose oxidoreductase domain							extracellular region	binding|oxidoreductase activity			ovary(2)	2	Breast(50;0.0296)|Ovarian(93;0.0454)	all_hematologic(90;0.135)	Epithelial(50;0.0348)|BRCA - Breast invasive adenocarcinoma(129;0.1)|all cancers(50;0.108)															---	---	---	---
Unknown	0	broad.mit.edu	37	6	13521431	13521431	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:13521431delA								GFOD1 (33644 upstream) : SIRT5 (53361 downstream)																																			---	---	---	---
SIRT5	23408	broad.mit.edu	37	6	13599058	13599063	+	Intron	DEL	AAAAAA	-	-	rs76997472		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:13599058_13599063delAAAAAA	uc003nay.2	+						SIRT5_uc003naw.2_Intron|SIRT5_uc003nax.2_Intron|SIRT5_uc011dit.1_Intron	NM_012241	NP_036373			sirtuin 5 isoform 1						chromatin silencing|protein ADP-ribosylation|protein deacetylation	mitochondrial intermembrane space|mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|zinc ion binding			skin(2)|upper_aerodigestive_tract(1)	3	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.176)		Suramin(DB04786)													---	---	---	---
SIRT5	23408	broad.mit.edu	37	6	13612197	13612197	+	3'UTR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:13612197delA	uc003nay.2	+	10					SIRT5_uc003nax.2_3'UTR|SIRT5_uc011dit.1_3'UTR	NM_012241	NP_036373			sirtuin 5 isoform 1						chromatin silencing|protein ADP-ribosylation|protein deacetylation	mitochondrial intermembrane space|mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|zinc ion binding			skin(2)|upper_aerodigestive_tract(1)	3	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.176)		Suramin(DB04786)													---	---	---	---
JARID2	3720	broad.mit.edu	37	6	15508639	15508639	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:15508639delC	uc003nbj.2	+	12	3044	c.2800delC	c.(2800-2802)CACfs	p.H934fs	JARID2_uc011div.1_Frame_Shift_Del_p.H762fs|JARID2_uc011diw.1_Frame_Shift_Del_p.H896fs	NM_004973	NP_004964	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2 protein	934	JmjC.				central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			ovary(2)|lung(1)|pancreas(1)	4	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)																---	---	---	---
MYLIP	29116	broad.mit.edu	37	6	16141709	16141709	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:16141709delT	uc003nbq.2	+						MYLIP_uc003nbr.2_Intron	NM_013262	NP_037394			myosin regulatory light chain interacting						cellular component movement|nervous system development	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|ubiquitin-protein ligase activity|zinc ion binding			pancreas(1)	1	Breast(50;0.0799)|Ovarian(93;0.103)	all_hematologic(90;0.0895)	Epithelial(50;0.241)															---	---	---	---
CAP2	10486	broad.mit.edu	37	6	17514215	17514215	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:17514215delA	uc003ncb.2	+						CAP2_uc010jpk.1_Intron|CAP2_uc011dja.1_Intron|CAP2_uc011djb.1_Intron|CAP2_uc011djc.1_Intron|CAP2_uc011djd.1_Intron	NM_006366	NP_006357			adenylyl cyclase-associated protein 2						activation of adenylate cyclase activity|axon guidance|cytoskeleton organization|establishment or maintenance of cell polarity|signal transduction	plasma membrane	actin binding			ovary(1)	1	Breast(50;0.0333)|Ovarian(93;0.0386)	all_hematologic(90;0.0466)	all cancers(50;0.194)|Epithelial(50;0.227)															---	---	---	---
TPMT	7172	broad.mit.edu	37	6	18134021	18134021	+	Intron	DEL	C	-	-	rs68138647		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:18134021delC	uc003ncm.2	-						TPMT_uc010jpm.1_Frame_Shift_Del_p.G198fs	NM_000367	NP_000358			thiopurine S-methyltransferase						xenobiotic metabolic process	cytosol	thiopurine S-methyltransferase activity				0	Ovarian(93;0.016)|Breast(50;0.0245)	all_hematologic(90;0.146)	all cancers(50;0.06)|Epithelial(50;0.0654)		Mercaptopurine(DB01033)													---	---	---	---
CDKAL1	54901	broad.mit.edu	37	6	21231418	21231418	+	3'UTR	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:21231418delC	uc003ndc.1	+	16					CDKAL1_uc003ndd.1_3'UTR|CDKAL1_uc003nde.1_3'UTR|CDKAL1_uc003ndf.1_3'UTR|CDKAL1_uc003ndg.2_RNA	NM_017774	NP_060244			CDK5 regulatory subunit associated protein						RNA modification	integral to membrane	4 iron, 4 sulfur cluster binding|metal ion binding|transferase activity			ovary(2)	2	all_epithelial(95;0.0708)|Breast(50;0.131)|Ovarian(93;0.227)		OV - Ovarian serous cystadenocarcinoma(7;0.0241)|all cancers(50;0.123)|Epithelial(50;0.248)															---	---	---	---
MRS2	57380	broad.mit.edu	37	6	24416484	24416484	+	Intron	DEL	T	-	-	rs35657958		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:24416484delT	uc003neb.2	+						MRS2_uc003nea.2_Intron|MRS2_uc011djl.1_Intron|MRS2_uc011djm.1_Intron|MRS2_uc011djn.1_Intron|MRS2_uc003nec.2_Intron	NM_020662	NP_065713			MRS2-like, magnesium homeostasis factor						ion transport	integral to membrane|mitochondrial inner membrane					0																		---	---	---	---
LRRC16A	55604	broad.mit.edu	37	6	25279940	25279940	+	5'UTR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:25279940delA	uc011djw.1	+	1					LRRC16A_uc010jpx.2_5'UTR|LRRC16A_uc010jpy.2_5'UTR	NM_017640	NP_060110			leucine rich repeat containing 16A						actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				ovary(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4																		---	---	---	---
BTN3A2	11118	broad.mit.edu	37	6	26373817	26373819	+	Intron	DEL	AAA	-	-	rs71863965		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:26373817_26373819delAAA	uc010jqh.1	+						BTN3A2_uc003nho.1_Intron|BTN3A2_uc003nhp.2_Intron|BTN3A2_uc011dkd.1_Intron|BTN3A2_uc011dke.1_Intron|BTN3A2_uc010jqi.1_Intron	NM_007047	NP_008978			butyrophilin, subfamily 3, member A2 precursor							integral to membrane					0																		---	---	---	---
HIST1H2BN	8341	broad.mit.edu	37	6	27806403	27806403	+	5'Flank	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:27806403delT	uc003njv.2	+						HIST1H2AK_uc003njs.2_5'Flank|HIST1H2BN_uc003njt.1_RNA|HIST1H2BN_uc003nju.1_5'UTR	NM_003520	NP_003511			histone cluster 1, H2bn						nucleosome assembly	nucleosome|nucleus	DNA binding				0																		---	---	---	---
ZSCAN23	222696	broad.mit.edu	37	6	28403542	28403542	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:28403542delA	uc003nli.3	-						ZSCAN23_uc003nlh.2_Intron|ZSCAN23_uc010jrf.1_Intron|ZSCAN23_uc011dli.1_Intron	NM_001012455	NP_001012458			zinc finger protein 390						viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0																		---	---	---	---
GPX5	2880	broad.mit.edu	37	6	28502011	28502011	+	3'UTR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:28502011delA	uc003nll.2	+	5					GPX5_uc003nlm.2_3'UTR|GPX5_uc003nln.2_RNA	NM_001509	NP_001500			glutathione peroxidase 5 isoform 1 precursor						lipid metabolic process|response to oxidative stress	extracellular region	glutathione peroxidase activity			skin(1)	1					Glutathione(DB00143)													---	---	---	---
HLA-A	3105	broad.mit.edu	37	6	29911457	29911458	+	Intron	INS	-	T	T	rs140855897	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:29911457_29911458insT	uc003nol.2	+						HLA-G_uc011dmb.1_Intron|HCG4P6_uc003nog.1_5'Flank|HLA-A_uc010jrq.2_Intron|HLA-A_uc003nok.2_Intron|HLA-A_uc003non.2_Intron|HLA-A_uc003noo.2_Intron|HLA-A_uc010jrr.2_Intron|HLA-A_uc003nom.2_Intron|HLA-A_uc010klp.2_Intron|HLA-A_uc011dmc.1_Intron|HLA-A_uc011dmd.1_Intron	NM_002116	NP_002107			major histocompatibility complex, class I, A						antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2														Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of|Osteosarcoma_Familial_Clustering_of|Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of	Multiple Myeloma(9;0.094)			---	---	---	---
TRIM26	7726	broad.mit.edu	37	6	30153579	30153579	+	3'UTR	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:30153579delC	uc003npr.2	-	9					TRIM26_uc003nps.2_3'UTR|TRIM26_uc010jry.2_3'UTR|TRIM26_uc003npt.2_3'UTR	NM_003449	NP_003440			tripartite motif-containing 26								DNA binding|zinc ion binding			ovary(2)|lung(1)	3																		---	---	---	---
HLA-E	3133	broad.mit.edu	37	6	30459582	30459582	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:30459582delT	uc003nqg.2	+						HLA-E_uc011dmg.1_Intron|HLA-E_uc011dmh.1_Intron	NM_005516	NP_005507			major histocompatibility complex, class I, E						antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity			central_nervous_system(4)|ovary(1)	5																		---	---	---	---
CCHCR1	54535	broad.mit.edu	37	6	31116617	31116617	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:31116617delG	uc003nsr.3	-						CCHCR1_uc011dne.1_Intron|CCHCR1_uc003nsq.3_Intron|CCHCR1_uc003nsp.3_Intron|CCHCR1_uc010jsk.1_Intron	NM_019052	NP_061925			coiled-coil alpha-helical rod protein 1 isoform						cell differentiation|multicellular organismal development	cytoplasm|nucleus	protein binding			skin(1)	1																		---	---	---	---
BAT2	7916	broad.mit.edu	37	6	31604804	31604804	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:31604804delT	uc003nvb.3	+						BAT2_uc003nvc.3_Intron	NM_080686	NP_542417			HLA-B associated transcript-2							cytoplasm|nucleus	protein binding				0																		---	---	---	---
LSM2	57819	broad.mit.edu	37	6	31765402	31765402	+	3'UTR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:31765402delA	uc003nxg.2	-	5					VARS_uc003nxe.2_5'Flank|VARS_uc011doi.1_5'Flank	NM_021177	NP_067000			LSM2 homolog, U6 small nuclear RNA associated						exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|cytosol|nucleoplasm	U6 snRNA binding				0																		---	---	---	---
CYP21A2	1589	broad.mit.edu	37	6	32006625	32006625	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:32006625delT	uc003nze.1	+						CYP21A2_uc003nzf.1_Intron	NM_000500	NP_000491			cytochrome P450, family 21, subfamily A,						glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|steroid 21-monooxygenase activity|steroid binding				0																		---	---	---	---
PPT2	9374	broad.mit.edu	37	6	32123888	32123889	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:32123888_32123889delTT	uc003nzx.2	+						uc003nzv.3_5'Flank|PPT2_uc003nzw.2_Intron|PPT2_uc011dpi.1_Intron|PPT2_uc003nzy.1_Intron|PPT2_uc003nzz.2_Intron|PPT2_uc003oaa.2_Intron|PPT2_uc010jtu.1_Intron	NM_005155	NP_005146			palmitoyl-protein thioesterase 2 isoform a						protein modification process	lysosome	palmitoyl-(protein) hydrolase activity				0																		---	---	---	---
HLA-DRB5	3127	broad.mit.edu	37	6	32497712	32497713	+	Intron	INS	-	A	A	rs146725750	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:32497712_32497713insA	uc003obj.2	-						HLA-DRB1_uc011dqa.1_Intron|HLA-DRB5_uc003obk.3_Intron	NM_002125	NP_002116			major histocompatibility complex, class II, DR						antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|immune response	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex					0																		---	---	---	---
TAP2	6891	broad.mit.edu	37	6	32805788	32805788	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:32805788delG	uc003occ.2	-	1	254	c.223delC	c.(223-225)CTGfs	p.L75fs	TAP2_uc011dqf.1_Frame_Shift_Del_p.L75fs|TAP2_uc003ocb.1_Frame_Shift_Del_p.L75fs|TAP2_uc003ocd.2_Frame_Shift_Del_p.L75fs	NM_018833	NP_061313	Q03519	TAP2_HUMAN	transporter 2, ATP-binding cassette, sub-family	75	Helical; Name=2; (Potential).				antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|cytosol to ER transport|intracellular transport of viral proteins in host cell|peptide antigen transport|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|positive regulation of T cell mediated cytotoxicity	nucleus|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|tapasin binding				0																		---	---	---	---
SNRPC	6631	broad.mit.edu	37	6	34738000	34738000	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:34738000delA	uc003ojt.1	+							NM_003093	NP_003084			small nuclear ribonucleoprotein polypeptide C						spliceosomal snRNP assembly	Cajal body|U1 snRNP	protein homodimerization activity|single-stranded RNA binding|zinc ion binding			pancreas(1)	1																		---	---	---	---
SNRPC	6631	broad.mit.edu	37	6	34741121	34741121	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:34741121delG	uc003ojt.1	+							NM_003093	NP_003084			small nuclear ribonucleoprotein polypeptide C						spliceosomal snRNP assembly	Cajal body|U1 snRNP	protein homodimerization activity|single-stranded RNA binding|zinc ion binding			pancreas(1)	1																		---	---	---	---
TAF11	6882	broad.mit.edu	37	6	34847943	34847943	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:34847943delT	uc003ojw.1	-						UHRF1BP1_uc010jvm.1_Intron|TAF11_uc011dsr.1_Intron	NM_005643	NP_005634			TBP-associated factor 11						positive regulation by host of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	transcription factor TFIID complex	protein N-terminus binding|thyroid hormone receptor binding|transcription coactivator activity|vitamin D receptor binding				0																		---	---	---	---
C6orf89	221477	broad.mit.edu	37	6	36869931	36869932	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:36869931_36869932insT	uc003omx.2	+						C6orf89_uc003omv.2_Intron|C6orf89_uc003omw.2_Intron|C6orf89_uc011dtr.1_Intron	NM_152734	NP_689947			hypothetical protein LOC221477							integral to membrane				ovary(1)	1																		---	---	---	---
TMEM217	221468	broad.mit.edu	37	6	37186118	37186119	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:37186118_37186119insT	uc003onl.2	-						TMEM217_uc010jwr.2_Intron|TMEM217_uc010jws.2_Intron|TMEM217_uc003onm.3_3'UTR	NM_145316	NP_660359			transmembrane protein 217 isoform 1							integral to membrane					0																		---	---	---	---
DNAH8	1769	broad.mit.edu	37	6	38885823	38885824	+	Frame_Shift_Ins	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:38885823_38885824insA	uc003ooe.1	+	68	10380_10381	c.9780_9781insA	c.(9778-9783)GCCAAAfs	p.A3260fs	uc003oof.1_Intron	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21																		---	---	---	---
NFYA	4800	broad.mit.edu	37	6	41057863	41057863	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:41057863delT	uc003opo.2	+						NFYA_uc003opp.2_Intron|NFYA_uc003opq.2_Intron	NM_002505	NP_002496			nuclear transcription factor Y, alpha isoform 1						transcription from RNA polymerase II promoter	CCAAT-binding factor complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(28;0.0418)|Colorectal(47;0.196)																	---	---	---	---
MED20	9477	broad.mit.edu	37	6	41888527	41888527	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:41888527delA	uc003ork.2	-						MED20_uc003orj.2_Intron|MED20_uc011duh.1_Intron|MED20_uc011dui.1_Intron|MED20_uc011duj.1_Intron|BYSL_uc003orl.2_5'Flank	NM_004275	NP_004266			Trf (TATA binding protein-related						regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	mediator complex	DNA-directed RNA polymerase activity|protein binding				0	Colorectal(47;0.121)		STAD - Stomach adenocarcinoma(11;0.000204)|Epithelial(12;0.000367)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)															---	---	---	---
UBR2	23304	broad.mit.edu	37	6	42643695	42643695	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:42643695delA	uc011dur.1	+						UBR2_uc011dus.1_Intron|UBR2_uc003osh.2_Intron|UBR2_uc011dut.1_Intron	NM_015255	NP_056070			ubiquitin protein ligase E3 component n-recognin						cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			ovary(3)|pancreas(1)	4	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)															---	---	---	---
PRPH2	5961	broad.mit.edu	37	6	42672517	42672518	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:42672517_42672518insA	uc003osk.2	-							NM_000322	NP_000313			peripherin 2						cell adhesion|visual perception	integral to membrane				ovary(4)|central_nervous_system(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.00178)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0904)															---	---	---	---
C6orf153	88745	broad.mit.edu	37	6	42993678	42993678	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:42993678delA	uc003otp.1	+							NM_033112	NP_149103			hypothetical protein LOC88745						ribosomal small subunit biogenesis|rRNA processing	nucleolus					0			Colorectal(64;0.00237)|all cancers(41;0.0034)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0539)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)															---	---	---	---
KLC4	89953	broad.mit.edu	37	6	43038277	43038277	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:43038277delT	uc003otv.1	+						KLC4_uc003otr.1_Intron|KLC4_uc011dvd.1_Intron|KLC4_uc003otw.1_Intron|KLC4_uc003otx.1_Intron|KLC4_uc003oty.1_Intron|KLC4_uc003otz.1_Intron	NM_201521	NP_958929			kinesin-like 8 isoform a							cytoplasm|kinesin complex|microtubule	microtubule motor activity|protein binding			skin(3)|ovary(1)	4			all cancers(41;0.00169)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0376)|KIRC - Kidney renal clear cell carcinoma(2;0.0453)													OREG0017448	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
CUL9	23113	broad.mit.edu	37	6	43190737	43190739	+	Intron	DEL	CTC	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:43190737_43190739delCTC	uc003ouk.2	+						CUL9_uc003oul.2_Intron|CUL9_uc010jyk.2_Intron|CUL9_uc003oun.2_Intron	NM_015089	NP_055904			p53-associated parkin-like cytoplasmic protein						ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12																		---	---	---	---
XPO5	57510	broad.mit.edu	37	6	43528049	43528049	+	Intron	DEL	A	-	-	rs74544728		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:43528049delA	uc003ovp.2	-							NM_020750	NP_065801			exportin 5						gene silencing by RNA	cytosol|nucleoplasm	protein binding|tRNA binding			skin(2)|breast(1)|kidney(1)	4	all_cancers(18;2.08e-05)|Lung NSC(15;0.000907)|all_lung(25;0.00243)		all cancers(41;0.000321)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0524)															---	---	---	---
C6orf223	221416	broad.mit.edu	37	6	43969836	43969836	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:43969836delC	uc003own.2	+	3	273	c.255delC	c.(253-255)CACfs	p.H85fs	uc003owm.1_Intron|C6orf223_uc003owo.2_Frame_Shift_Del_p.H65fs	NM_153246	NP_694978	Q8N319	CF223_HUMAN	hypothetical protein LOC221416	85											0	all_cancers(18;2.28e-07)|all_epithelial(2;1.62e-08)|Lung NSC(15;0.000172)|all_lung(25;0.000533)|Hepatocellular(11;0.00309)|Ovarian(13;0.0437)		all cancers(41;0.00141)|Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.217)															---	---	---	---
SLC35B2	347734	broad.mit.edu	37	6	44223448	44223451	+	Intron	DEL	CTCT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:44223448_44223451delCTCT	uc003oxd.2	-						SLC35B2_uc011dvt.1_Intron|SLC35B2_uc011dvu.1_Intron	NM_178148	NP_835361			solute carrier family 35, member B2						positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity|signal transducer activity			ovary(1)|central_nervous_system(1)	2	all_cancers(18;2e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)															---	---	---	---
C6orf138	442213	broad.mit.edu	37	6	47846151	47846151	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:47846151delA	uc011dwm.1	-	3	2463	c.2378delT	c.(2377-2379)TTCfs	p.F793fs	C6orf138_uc011dwn.1_Frame_Shift_Del_p.F557fs	NM_001013732	NP_001013754	Q6ZW05	CF138_HUMAN	hypothetical protein LOC442213	810						integral to membrane	hedgehog receptor activity			central_nervous_system(1)	1																		---	---	---	---
MUT	4594	broad.mit.edu	37	6	49408202	49408202	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:49408202delT	uc003ozg.3	-							NM_000255	NP_000246			methylmalonyl Coenzyme A mutase precursor						fatty acid beta-oxidation	mitochondrial matrix	cobalamin binding|metal ion binding|methylmalonyl-CoA mutase activity				0	Lung NSC(77;0.0376)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)													---	---	---	---
PKHD1	5314	broad.mit.edu	37	6	51606194	51606195	+	Intron	DEL	TT	-	-	rs71894206		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:51606194_51606195delTT	uc003pah.1	-						PKHD1_uc010jzn.1_Intron|PKHD1_uc003pai.2_Intron	NM_138694	NP_619639			fibrocystin isoform 1						cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)																	---	---	---	---
PKHD1	5314	broad.mit.edu	37	6	51921383	51921383	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:51921383delT	uc003pah.1	-						PKHD1_uc003pai.2_Intron	NM_138694	NP_619639			fibrocystin isoform 1						cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)																	---	---	---	---
PKHD1	5314	broad.mit.edu	37	6	51929876	51929877	+	Intron	DEL	TG	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:51929876_51929877delTG	uc003pah.1	-						PKHD1_uc003pai.2_Intron	NM_138694	NP_619639			fibrocystin isoform 1						cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)																	---	---	---	---
TMEM14A	28978	broad.mit.edu	37	6	52546594	52546594	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:52546594delT	uc003pax.2	+							NM_014051	NP_054770			transmembrane protein 14A							integral to membrane					0	Lung NSC(77;0.118)																	---	---	---	---
GSTA3	2940	broad.mit.edu	37	6	52765063	52765065	+	Intron	DEL	TTT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:52765063_52765065delTTT	uc003pbb.2	-						GSTA3_uc010jzq.2_Intron	NM_000847	NP_000838			glutathione S-transferase alpha 3						glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity				0	Lung NSC(77;0.0912)				Glutathione(DB00143)													---	---	---	---
FBXO9	26268	broad.mit.edu	37	6	52962507	52962507	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:52962507delT	uc003pbo.2	+						FBXO9_uc003pbk.2_Intron|FBXO9_uc003pbl.2_Intron|FBXO9_uc003pbm.2_Intron|FBXO9_uc003pbn.2_Intron	NM_012347	NP_036479			F-box only protein 9 isoform 1							ubiquitin ligase complex	ubiquitin-protein ligase activity			pancreas(1)	1	Lung NSC(77;0.103)																	---	---	---	---
COL21A1	81578	broad.mit.edu	37	6	56047463	56047463	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:56047463delA	uc003pcs.2	-						COL21A1_uc003pct.1_Intron|COL21A1_uc011dxi.1_Intron|COL21A1_uc003pcu.1_Intron	NM_030820	NP_110447			collagen, type XXI, alpha 1 precursor						cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(2)	2	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)															---	---	---	---
DST	667	broad.mit.edu	37	6	56382365	56382365	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:56382365delT	uc003pdf.2	-	64	11854	c.11826delA	c.(11824-11826)AAAfs	p.K3942fs	DST_uc003pcz.3_Frame_Shift_Del_p.K3764fs|DST_uc011dxj.1_Frame_Shift_Del_p.K3793fs|DST_uc011dxk.1_Frame_Shift_Del_p.K3804fs|DST_uc003pcy.3_Frame_Shift_Del_p.K3438fs	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	5850	Spectrin 10.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)															---	---	---	---
DST	667	broad.mit.edu	37	6	56476324	56476324	+	Frame_Shift_Del	DEL	A	-	-	rs35805169		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:56476324delA	uc003pdf.2	-	37	5058	c.5030delT	c.(5029-5031)TTGfs	p.L1677fs	DST_uc003pcz.3_Frame_Shift_Del_p.L1499fs|DST_uc011dxj.1_Frame_Shift_Del_p.L1528fs|DST_uc011dxk.1_Frame_Shift_Del_p.L1539fs|DST_uc003pcy.3_Frame_Shift_Del_p.L1173fs|DST_uc003pdb.2_Frame_Shift_Del_p.L1173fs	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)															---	---	---	---
LGSN	51557	broad.mit.edu	37	6	63989792	63989792	+	3'UTR	DEL	A	-	-	rs79900249		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:63989792delA	uc003peh.2	-	4					LGSN_uc003pei.2_3'UTR	NM_016571	NP_057655			lengsin, lens protein with glutamine synthetase						glutamine biosynthetic process		glutamate-ammonia ligase activity			skin(2)	2					L-Glutamic Acid(DB00142)													---	---	---	---
EYS	346007	broad.mit.edu	37	6	66054075	66054075	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:66054075delA	uc011dxu.1	-						EYS_uc003peq.2_Intron|EYS_uc003per.1_Intron	NM_001142800	NP_001136272			eyes shut homolog isoform 1						response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6																		---	---	---	---
BAI3	577	broad.mit.edu	37	6	69728430	69728430	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:69728430delA	uc003pev.3	+						BAI3_uc010kak.2_Intron	NM_001704	NP_001695			brain-specific angiogenesis inhibitor 3						negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)																---	---	---	---
LMBRD1	55788	broad.mit.edu	37	6	70459210	70459210	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:70459210delA	uc003pfa.2	-						LMBRD1_uc003pez.2_Intron|LMBRD1_uc010kal.2_Intron|LMBRD1_uc003pfb.2_Intron	NM_018368	NP_060838			liver regeneration p-53 related protein						interspecies interaction between organisms|transport	integral to membrane|lysosomal membrane	cobalamin binding			ovary(1)	1																		---	---	---	---
RIMS1	22999	broad.mit.edu	37	6	72952000	72952000	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:72952000delT	uc003pga.2	+						RIMS1_uc011dyb.1_Intron|RIMS1_uc003pgc.2_Intron|RIMS1_uc010kaq.2_Intron|RIMS1_uc011dyc.1_Intron|RIMS1_uc010kar.2_Intron|RIMS1_uc011dyd.1_Intron|RIMS1_uc003pgb.3_Intron|RIMS1_uc010kas.1_Intron	NM_014989	NP_055804			regulating synaptic membrane exocytosis 1						calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)																---	---	---	---
KCNQ5	56479	broad.mit.edu	37	6	73787656	73787656	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:73787656delT	uc003pgk.2	+						KCNQ5_uc003pgj.3_Intron|KCNQ5_uc011dyh.1_Intron|KCNQ5_uc011dyi.1_Intron|KCNQ5_uc010kat.2_Intron|KCNQ5_uc011dyj.1_Intron|KCNQ5_uc011dyk.1_Intron	NM_019842	NP_062816			potassium voltage-gated channel, KQT-like						protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)														---	---	---	---
DDX43	55510	broad.mit.edu	37	6	74123238	74123238	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:74123238delT	uc003pgw.2	+							NM_018665	NP_061135			DEAD (Asp-Glu-Ala-Asp) box polypeptide 43							intracellular	ATP binding|ATP-dependent RNA helicase activity|RNA binding			ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4																		---	---	---	---
COL12A1	1303	broad.mit.edu	37	6	75798721	75798722	+	Intron	DEL	AC	-	-	rs672648		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:75798721_75798722delAC	uc003phs.2	-						COL12A1_uc003pht.2_Intron	NM_004370	NP_004361			collagen, type XII, alpha 1 long isoform						cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9																		---	---	---	---
SENP6	26054	broad.mit.edu	37	6	76376716	76376716	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:76376716delT	uc003pid.3	+						SENP6_uc003pie.3_Intron|SENP6_uc010kbf.2_Intron|SENP6_uc003pic.2_Intron|SENP6_uc003pif.1_Intron	NM_015571	NP_056386			SUMO1/sentrin specific peptidase 6 isoform 1						proteolysis	cytoplasm|nucleus	cysteine-type peptidase activity			breast(2)|urinary_tract(1)|ovary(1)|lung(1)|skin(1)	6		all_hematologic(105;0.189)																---	---	---	---
MYO6	4646	broad.mit.edu	37	6	76542706	76542706	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:76542706delT	uc003pih.1	+						MYO6_uc003pig.1_Intron|MYO6_uc003pii.1_Intron	NM_004999	NP_004990			myosin VI						actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			kidney(1)|pancreas(1)	2		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)														---	---	---	---
PHIP	55023	broad.mit.edu	37	6	79679504	79679504	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:79679504delA	uc003pir.2	-						PHIP_uc003piq.2_Intron|PHIP_uc011dyp.1_Intron	NM_017934	NP_060404			pleckstrin homology domain interacting protein						insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	6		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)														---	---	---	---
TTK	7272	broad.mit.edu	37	6	80751910	80751910	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:80751910delA	uc003pjc.2	+	22	2639	c.2565delA	c.(2563-2565)GGAfs	p.G855fs	TTK_uc003pjb.3_Frame_Shift_Del_p.G854fs	NM_003318	NP_003309	P33981	TTK_HUMAN	TTK protein kinase	855					mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(4)|stomach(2)|lung(2)|large_intestine(2)|pancreas(1)	11		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)														---	---	---	---
Unknown	0	broad.mit.edu	37	6	81265465	81265465	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:81265465delT								BCKDHB (209478 upstream) : None (None downstream)																																			---	---	---	---
ME1	4199	broad.mit.edu	37	6	84056671	84056672	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:84056671_84056672insT	uc003pjy.2	-						ME1_uc011dzb.1_Intron|ME1_uc011dzc.1_Intron	NM_002395	NP_002386			cytosolic malic enzyme 1						carbohydrate metabolic process|cellular lipid metabolic process|malate metabolic process|NADP biosynthetic process|response to carbohydrate stimulus|response to hormone stimulus	cytosol	ADP binding|electron carrier activity|malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|manganese ion binding|NAD binding|NADP binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(76;1.28e-06)|Acute lymphoblastic leukemia(125;5.03e-07)|all_hematologic(105;0.000238)|all_epithelial(107;0.00218)		BRCA - Breast invasive adenocarcinoma(397;0.0641)	NADH(DB00157)													---	---	---	---
SNAP91	9892	broad.mit.edu	37	6	84333106	84333107	+	Intron	INS	-	T	T	rs148344322	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:84333106_84333107insT	uc011dze.1	-						SNAP91_uc003pkb.2_Intron|SNAP91_uc003pkc.2_Intron|SNAP91_uc003pkd.2_Intron|SNAP91_uc003pka.2_Intron|SNAP91_uc011dzf.1_Intron	NM_014841	NP_055656			synaptosomal-associated protein, 91kDa homolog						clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			ovary(1)	1		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)														---	---	---	---
CYB5R4	51167	broad.mit.edu	37	6	84618858	84618858	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:84618858delT	uc003pkf.2	+							NM_016230	NP_057314			cytochrome b5 reductase 4						cell development|detection of oxygen|generation of precursor metabolites and energy|glucose homeostasis|insulin secretion|response to antibiotic|superoxide metabolic process	endoplasmic reticulum|perinuclear region of cytoplasm	cytochrome-b5 reductase activity|heme binding|NAD(P)H oxidase activity			breast(2)	2		all_cancers(76;7e-07)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00128)		BRCA - Breast invasive adenocarcinoma(397;0.0871)														---	---	---	---
SNHG5	387066	broad.mit.edu	37	6	86386983	86386983	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:86386983delA	uc003plb.3	-						SNHG5_uc003plc.3_Intron|SNHG5_uc003pld.3_Intron|SNHG5_uc003plf.2_RNA					Homo sapiens chromosome 6 open reading frame 160, mRNA (cDNA clone IMAGE:3927795).												0																		---	---	---	---
RNGTT	8732	broad.mit.edu	37	6	89614294	89614295	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:89614294_89614295delTT	uc003pmr.2	-						RNGTT_uc003pms.2_Intron|RNGTT_uc011dzu.1_Intron|RNGTT_uc003pmt.2_Intron	NM_003800	NP_003791			RNA guanylyltransferase and 5'-phosphatase						interspecies interaction between organisms|mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	GTP binding|mRNA guanylyltransferase activity|polynucleotide 5'-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			upper_aerodigestive_tract(1)	1		all_cancers(76;4.07e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;6.86e-05)		BRCA - Breast invasive adenocarcinoma(108;0.151)														---	---	---	---
LYRM2	57226	broad.mit.edu	37	6	90347730	90347730	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:90347730delT	uc003pnm.2	-						LYRM2_uc010kce.1_Intron|LYRM2_uc003png.2_Intron|LYRM2_uc010kcf.1_Intron|LYRM2_uc010kcg.2_Intron|LYRM2_uc003pnl.3_Intron	NM_020466	NP_065199			LYR motif containing 2												0		all_cancers(76;2.76e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;3.72e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0131)														---	---	---	---
CASP8AP2	9994	broad.mit.edu	37	6	90571823	90571823	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:90571823delT	uc003pnr.2	+						CASP8AP2_uc003pns.2_Intron|CASP8AP2_uc003pnt.2_Intron|CASP8AP2_uc011dzz.1_Intron	NM_001137667	NP_001131139			caspase 8 associated protein 2						cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			ovary(2)	2		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)														---	---	---	---
MAP3K7	6885	broad.mit.edu	37	6	91245899	91245899	+	Intron	DEL	T	-	-	rs35103741		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:91245899delT	uc003pnz.1	-						MAP3K7_uc003pny.1_Intron|MAP3K7_uc003poa.1_Intron|MAP3K7_uc003pob.1_Intron|MAP3K7_uc003poc.1_Intron	NM_145331	NP_663304			mitogen-activated protein kinase kinase kinase 7						activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|histone H3 acetylation|I-kappaB phosphorylation|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytosol|endosome membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|stomach(1)	6		all_cancers(76;6.4e-08)|Acute lymphoblastic leukemia(125;1.43e-09)|Prostate(29;9.32e-09)|all_hematologic(105;3.69e-06)|all_epithelial(107;0.000187)|Ovarian(999;0.0164)		OV - Ovarian serous cystadenocarcinoma(136;2.05e-11)|all cancers(137;3.25e-11)|GBM - Glioblastoma multiforme(226;0.0416)|BRCA - Breast invasive adenocarcinoma(108;0.0429)														---	---	---	---
USP45	85015	broad.mit.edu	37	6	99883880	99883881	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:99883880_99883881delTT	uc003ppx.2	-						USP45_uc003ppv.2_Intron|USP45_uc003ppw.2_Intron	NM_001080481	NP_001073950			ubiquitin specific peptidase 45						ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|breast(1)	2		all_cancers(76;0.000208)|Acute lymphoblastic leukemia(125;8.41e-11)|all_hematologic(75;2.56e-07)|all_epithelial(107;0.122)|Colorectal(196;0.133)		BRCA - Breast invasive adenocarcinoma(108;0.0718)														---	---	---	---
MCHR2	84539	broad.mit.edu	37	6	100382131	100382131	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:100382131delA	uc003pqh.1	-						MCHR2_uc003pqi.1_Intron	NM_001040179	NP_001035269			melanin-concentrating hormone receptor 2							integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	8		all_cancers(76;4.87e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0309)|Colorectal(196;0.069)		BRCA - Breast invasive adenocarcinoma(108;0.0429)														---	---	---	---
ASCC3	10973	broad.mit.edu	37	6	101296336	101296336	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:101296336delA	uc003pqk.2	-	4	818	c.489delT	c.(487-489)TTTfs	p.F163fs	ASCC3_uc011eai.1_Frame_Shift_Del_p.F65fs|ASCC3_uc003pql.2_Frame_Shift_Del_p.F163fs|ASCC3_uc010kcv.2_Frame_Shift_Del_p.F163fs	NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	163					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)														---	---	---	---
Unknown	0	broad.mit.edu	37	6	107231882	107231883	+	Intron	DEL	TC	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:107231882_107231883delTC	uc003pro.1	-						MIR587_hsa-mir-587|MI0003595_5'Flank					Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 1534000.																														---	---	---	---
BEND3	57673	broad.mit.edu	37	6	107391602	107391602	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:107391602delC	uc003prs.2	-	5	1443	c.793delG	c.(793-795)GACfs	p.D265fs		NM_001080450	NP_001073919	Q5T5X7	BEND3_HUMAN	BEN domain containing 3	265	BEN 1.									ovary(3)	3																		---	---	---	---
C6orf182	285753	broad.mit.edu	37	6	109467946	109467947	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:109467946_109467947insT	uc010kdk.2	+						C6orf182_uc003psv.3_Intron|C6orf182_uc003psw.3_Intron|C6orf182_uc003psx.3_Intron|C6orf182_uc010kdl.2_Intron|C6orf182_uc003psy.3_Intron	NM_001083535	NP_001077004			hypothetical protein LOC285753							microtubule|microtubule organizing center					0		all_cancers(87;4.45e-07)|Acute lymphoblastic leukemia(125;2.15e-10)|all_hematologic(75;3.25e-08)|all_epithelial(87;0.000254)|Colorectal(196;0.0293)|all_lung(197;0.11)		BRCA - Breast invasive adenocarcinoma(108;0.00123)|Epithelial(106;0.0022)|all cancers(137;0.00405)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)														---	---	---	---
MICAL1	64780	broad.mit.edu	37	6	109769198	109769198	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:109769198delG	uc003ptj.2	-						MICAL1_uc003ptk.2_Intron|MICAL1_uc010kdr.2_Intron|MICAL1_uc011eaq.1_Intron	NM_022765	NP_073602			microtubule associated monoxygenase, calponin						cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			breast(2)|ovary(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)														---	---	---	---
ZBTB24	9841	broad.mit.edu	37	6	109796700	109796700	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:109796700delA	uc003ptl.1	-						ZBTB24_uc011ear.1_Intron|ZBTB24_uc010kds.1_Intron|ZBTB24_uc010kdt.1_Intron	NM_014797	NP_055612			zinc finger and BTB domain containing 24 isoform						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0154)|all cancers(137;0.0216)|OV - Ovarian serous cystadenocarcinoma(136;0.0242)|BRCA - Breast invasive adenocarcinoma(108;0.059)														---	---	---	---
AKD1	221264	broad.mit.edu	37	6	109982133	109982133	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:109982133delT	uc003ptn.2	-						AKD1_uc003ptr.3_Intron|AKD1_uc003pts.1_Intron	NM_001145128	NP_001138600			adenylate kinase domain containing 1 isoform 1						nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|nucleoside-triphosphatase activity			ovary(1)	1																		---	---	---	---
FIG4	9896	broad.mit.edu	37	6	110106148	110106148	+	Intron	DEL	T	-	-	rs80037216		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:110106148delT	uc003ptt.2	+						FIG4_uc011eau.1_Intron	NM_014845	NP_055660			Sac domain-containing inositol phosphatase 3						cell death	endosome membrane	protein binding			ovary(1)	1		all_cancers(87;8.63e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000124)|all_lung(197;0.0187)|Colorectal(196;0.0492)|Lung SC(18;0.0548)		OV - Ovarian serous cystadenocarcinoma(136;0.0355)|Epithelial(106;0.038)|all cancers(137;0.0425)|BRCA - Breast invasive adenocarcinoma(108;0.079)														---	---	---	---
WASF1	8936	broad.mit.edu	37	6	110423574	110423574	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:110423574delA	uc003ptv.1	-						WASF1_uc003ptw.1_Intron|WASF1_uc003ptx.1_Intron|WASF1_uc003pty.1_Intron	NM_003931	NP_003922			Wiskott-Aldrich syndrome protein family member						actin filament polymerization|cellular component movement	actin cytoskeleton	actin binding				0		all_cancers(87;1.18e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		OV - Ovarian serous cystadenocarcinoma(136;0.0364)|Epithelial(106;0.051)|all cancers(137;0.0687)														---	---	---	---
WASF1	8936	broad.mit.edu	37	6	110426584	110426584	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:110426584delA	uc003ptv.1	-						WASF1_uc003ptw.1_Intron|WASF1_uc003ptx.1_Intron|WASF1_uc003pty.1_Intron	NM_003931	NP_003922			Wiskott-Aldrich syndrome protein family member						actin filament polymerization|cellular component movement	actin cytoskeleton	actin binding				0		all_cancers(87;1.18e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		OV - Ovarian serous cystadenocarcinoma(136;0.0364)|Epithelial(106;0.051)|all cancers(137;0.0687)														---	---	---	---
CDC40	51362	broad.mit.edu	37	6	110514616	110514616	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:110514616delT	uc003pua.2	+							NM_015891	NP_056975			cell division cycle 40 homolog						mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm					0		all_cancers(87;6.23e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		Epithelial(106;0.0221)|all cancers(137;0.0314)|OV - Ovarian serous cystadenocarcinoma(136;0.034)														---	---	---	---
CDC40	51362	broad.mit.edu	37	6	110530267	110530267	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:110530267delT	uc003pua.2	+							NM_015891	NP_056975			cell division cycle 40 homolog						mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm					0		all_cancers(87;6.23e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		Epithelial(106;0.0221)|all cancers(137;0.0314)|OV - Ovarian serous cystadenocarcinoma(136;0.034)														---	---	---	---
SLC22A16	85413	broad.mit.edu	37	6	110759902	110759902	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:110759902delA	uc003puf.2	-						SLC22A16_uc003pue.2_Intron	NM_033125	NP_149116			solute carrier family 22, member 16						acid secretion|cell differentiation|multicellular organismal development|single fertilization|sperm motility|spermatogenesis	integral to membrane	carnitine transporter activity			ovary(1)	1		all_cancers(87;0.00221)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0485)|Colorectal(196;0.101)		OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.0921)|all cancers(137;0.115)														---	---	---	---
KIAA1919	91749	broad.mit.edu	37	6	111583373	111583373	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:111583373delT	uc003puv.3	+							NM_153369	NP_699200			sodium-dependent glucose transporter 1						carbohydrate transport|sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			ovary(3)	3		all_cancers(87;2.35e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.0209)		OV - Ovarian serous cystadenocarcinoma(136;0.055)|all cancers(137;0.0871)|Epithelial(106;0.0884)														---	---	---	---
KIAA1919	91749	broad.mit.edu	37	6	111587016	111587016	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:111587016delT	uc003puv.3	+							NM_153369	NP_699200			sodium-dependent glucose transporter 1						carbohydrate transport|sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			ovary(3)	3		all_cancers(87;2.35e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.0209)		OV - Ovarian serous cystadenocarcinoma(136;0.055)|all cancers(137;0.0871)|Epithelial(106;0.0884)														---	---	---	---
REV3L	5980	broad.mit.edu	37	6	111650708	111650708	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:111650708delA	uc003puy.3	-						REV3L_uc003pux.3_Intron|REV3L_uc003puz.3_Intron|REV3L_uc003pva.1_Intron	NM_002912	NP_002903			DNA polymerase zeta						DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)									DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					---	---	---	---
REV3L	5980	broad.mit.edu	37	6	111665249	111665249	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:111665249delA	uc003puy.3	-						REV3L_uc003pux.3_Intron|REV3L_uc003puz.3_Intron|REV3L_uc003pva.1_Intron	NM_002912	NP_002903			DNA polymerase zeta						DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)									DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					---	---	---	---
HS3ST5	222537	broad.mit.edu	37	6	114378234	114378234	+	3'UTR	DEL	T	-	-	rs80329057		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:114378234delT	uc003pwg.3	-	2					uc003pwf.2_Intron|HS3ST5_uc003pwh.3_3'UTR	NM_153612	NP_705840			heparan sulfate (glucosamine)						heparan sulfate proteoglycan biosynthetic process, enzymatic modification|negative regulation of coagulation|protein sulfation|regulation of virion penetration into host cell	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|protein binding			ovary(1)|pancreas(1)	2		all_cancers(87;0.0587)|Colorectal(196;0.0676)|all_epithelial(87;0.154)		OV - Ovarian serous cystadenocarcinoma(136;0.00937)|all cancers(137;0.0117)|Epithelial(106;0.0274)|GBM - Glioblastoma multiforme(226;0.143)														---	---	---	---
KPNA5	3841	broad.mit.edu	37	6	117026119	117026119	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:117026119delT	uc003pxh.2	+							NM_002269	NP_002260			karyopherin alpha 5						NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding|protein transporter activity			breast(3)|skin(1)	4		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0298)|all cancers(137;0.0461)|OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.212)														---	---	---	---
GPRC6A	222545	broad.mit.edu	37	6	117117013	117117013	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:117117013delA	uc003pxj.1	-						GPRC6A_uc003pxk.1_Intron|GPRC6A_uc003pxl.1_Intron	NM_148963	NP_683766			G protein-coupled receptor, family C, group 6,						response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)														---	---	---	---
SERINC1	57515	broad.mit.edu	37	6	122768178	122768178	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:122768178delA	uc003pyy.1	-						SERINC1_uc003pyx.1_5'Flank	NM_020755	NP_065806			serine incorporator 1						phosphatidylserine metabolic process|phospholipid biosynthetic process|positive regulation of transferase activity|sphingolipid metabolic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	L-serine transmembrane transporter activity|protein binding			ovary(1)	1				GBM - Glioblastoma multiforme(226;0.126)														---	---	---	---
NKAIN2	154215	broad.mit.edu	37	6	124979215	124979215	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:124979215delA	uc003pzo.2	+						NKAIN2_uc003pzn.1_Intron|NKAIN2_uc003pzp.2_Intron|NKAIN2_uc010keq.2_Intron|NKAIN2_uc010ker.2_Intron	NM_001040214	NP_001035304			T-cell lymphoma breakpoint-associated target 1							integral to membrane|plasma membrane					0				GBM - Glioblastoma multiforme(226;0.104)														---	---	---	---
RNF217	154214	broad.mit.edu	37	6	125330620	125330620	+	Intron	DEL	A	-	-	rs112538609		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:125330620delA	uc003pzs.2	+						RNF217_uc003pzr.2_Intron|RNF217_uc003pzt.2_Intron	NM_152553	NP_689766			ring finger protein 217						protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding				0			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0162)														---	---	---	---
TPD52L1	7164	broad.mit.edu	37	6	125493315	125493316	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:125493315_125493316insT	uc003pzu.1	+						TPD52L1_uc003pzv.1_Intron|TPD52L1_uc003pzw.1_Intron|TPD52L1_uc003pzx.1_Intron|TPD52L1_uc003pzy.1_Intron	NM_003287	NP_003278			tumor protein D52-like 1 isoform 1						DNA fragmentation involved in apoptotic nuclear change|G2/M transition of mitotic cell cycle|induction of apoptosis|positive regulation of JNK cascade|positive regulation of MAP kinase activity	perinuclear region of cytoplasm	caspase activator activity|protein heterodimerization activity|protein homodimerization activity				0			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0265)														---	---	---	---
THEMIS	387357	broad.mit.edu	37	6	128031170	128031170	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:128031170delA	uc003qbi.2	-						THEMIS_uc010kfa.2_Intron|THEMIS_uc011ebt.1_Intron|THEMIS_uc010kfb.2_Intron	NM_001010923	NP_001010923			thymocyte selection pathway associated isoform						negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4																		---	---	---	---
PTPRK	5796	broad.mit.edu	37	6	128321487	128321487	+	Intron	DEL	A	-	-	rs113113294		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:128321487delA	uc003qbk.2	-						PTPRK_uc003qbj.2_Intron|PTPRK_uc010kfc.2_Intron|PTPRK_uc011ebu.1_Intron|PTPRK_uc003qbl.1_Intron|PTPRK_uc011ebv.1_Intron|PTPRK_uc010kfd.1_Intron	NM_002844	NP_002835			protein tyrosine phosphatase, receptor type, K						cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)														---	---	---	---
PTPRK	5796	broad.mit.edu	37	6	128718505	128718505	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:128718505delT	uc003qbk.2	-						PTPRK_uc003qbj.2_Intron|PTPRK_uc010kfc.2_Intron|PTPRK_uc011ebu.1_Intron|PTPRK_uc003qbl.1_Intron|PTPRK_uc011ebv.1_Intron|PTPRK_uc003qbm.3_Intron	NM_002844	NP_002835			protein tyrosine phosphatase, receptor type, K						cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)														---	---	---	---
L3MBTL3	84456	broad.mit.edu	37	6	130370829	130370829	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:130370829delT	uc003qbt.2	+						L3MBTL3_uc003qbu.2_Intron	NM_032438	NP_115814			l(3)mbt-like 3 isoform a						chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.0266)|OV - Ovarian serous cystadenocarcinoma(155;0.154)														---	---	---	---
EPB41L2	2037	broad.mit.edu	37	6	131199492	131199492	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:131199492delA	uc003qch.2	-						EPB41L2_uc003qce.1_Intron|EPB41L2_uc003qcf.1_Intron|EPB41L2_uc003qcg.1_Intron|EPB41L2_uc011eby.1_Intron|EPB41L2_uc003qci.2_Intron|EPB41L2_uc010kfk.2_Intron|EPB41L2_uc010kfl.1_Intron|EPB41L2_uc003qcj.1_5'Flank	NM_001431	NP_001422			erythrocyte membrane protein band 4.1-like 2						cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			central_nervous_system(1)|skin(1)	2	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)														---	---	---	---
AKAP7	9465	broad.mit.edu	37	6	131481276	131481276	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:131481276delA	uc003qck.2	+	3	262	c.229delA	c.(229-231)AAAfs	p.K77fs	AKAP7_uc011ebz.1_Frame_Shift_Del_p.K55fs	NM_016377	NP_057461	O43687	AKA7A_HUMAN	A-kinase anchor protein 7 isoform gamma	Error:Variant_position_missing_in_O43687_after_alignment					intracellular signal transduction|ion transport	apical plasma membrane|intracellular|lateral plasma membrane	protein kinase A binding			ovary(2)	2	Breast(56;0.152)			GBM - Glioblastoma multiforme(226;0.0184)|OV - Ovarian serous cystadenocarcinoma(155;0.0345)														---	---	---	---
ENPP3	5169	broad.mit.edu	37	6	131992278	131992278	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:131992278delT	uc003qcu.3	+						ENPP3_uc010kfn.1_Intron|ENPP3_uc011ecc.1_Intron|ENPP3_uc010kfo.1_Intron|ENPP3_uc010kfp.1_Intron|ENPP3_uc010kfq.2_Intron|ENPP3_uc003qcv.2_Intron	NM_005021	NP_005012			ectonucleotide pyrophosphatase/phosphodiesterase						immune response|nucleoside triphosphate catabolic process|phosphate metabolic process	extracellular region|integral to plasma membrane|perinuclear region of cytoplasm	metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity			ovary(3)|skin(1)	4	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0252)|OV - Ovarian serous cystadenocarcinoma(155;0.0511)														---	---	---	---
Unknown	0	broad.mit.edu	37	6	132083043	132083043	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:132083043delT								ENPP3 (14494 upstream) : ENPP1 (46113 downstream)																																			---	---	---	---
MYB	4602	broad.mit.edu	37	6	135520107	135520107	+	Frame_Shift_Del	DEL	C	-	-	rs66549477		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:135520107delC	uc003qfc.2	+	10	1464	c.1265delC	c.(1264-1266)ACCfs	p.T422fs	MYB_uc003qfh.2_Frame_Shift_Del_p.T543fs|MYB_uc003qfi.2_Frame_Shift_Del_p.T527fs|MYB_uc010kgi.2_Frame_Shift_Del_p.T422fs|MYB_uc003qfq.2_Frame_Shift_Del_p.T540fs|MYB_uc010kgj.2_Frame_Shift_Del_p.T387fs|MYB_uc003qfo.2_Frame_Shift_Del_p.T337fs|MYB_uc003qfu.2_Frame_Shift_Del_p.T419fs|MYB_uc003qfl.2_RNA|MYB_uc003qfv.2_RNA|MYB_uc003qfz.2_RNA|MYB_uc003qfx.2_RNA|MYB_uc003qga.2_RNA|MYB_uc003qgb.2_RNA|MYB_uc010kgk.2_RNA|MYB_uc003qfd.2_RNA|MYB_uc003qfe.2_RNA|MYB_uc003qfg.2_RNA|MYB_uc003qff.2_RNA|MYB_uc003qfj.2_RNA|MYB_uc003qfm.2_RNA|MYB_uc003qfp.2_RNA|MYB_uc003qfn.2_RNA|MYB_uc003qfk.2_RNA|MYB_uc003qfr.2_RNA|MYB_uc003qfs.2_Frame_Shift_Del_p.T48fs|MYB_uc003qft.2_RNA|MYB_uc003qfw.2_Frame_Shift_Del_p.T234fs|MYB_uc003qfy.2_RNA|MYB_uc003qgc.2_RNA|MYB_uc003qfb.1_Frame_Shift_Del_p.T422fs	NM_005375	NP_005366	P10242	MYB_HUMAN	v-myb myeloblastosis viral oncogene homolog	422	Negative regulatory domain (By similarity).				blood coagulation|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone H3-K4 methylation|positive regulation of histone H3-K9 methylation|positive regulation of T-helper cell differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear matrix	DNA binding|protein binding			lung(1)	1	all_epithelial(2;0.109)|Breast(56;0.158)|Colorectal(23;0.221)	Lung NSC(302;3.08e-05)|Ovarian(999;0.208)		OV - Ovarian serous cystadenocarcinoma(155;0.0079)|GBM - Glioblastoma multiforme(68;0.0117)				T	NFIB	adenoid cystic carcinoma								---	---	---	---
AHI1	54806	broad.mit.edu	37	6	135784284	135784284	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:135784284delT	uc003qgi.2	-	8	1294	c.910delA	c.(910-912)ACAfs	p.T304fs	AHI1_uc003qgh.2_Frame_Shift_Del_p.T304fs|AHI1_uc003qgj.2_Frame_Shift_Del_p.T304fs|AHI1_uc003qgk.3_RNA|AHI1_uc003qgl.3_Frame_Shift_Del_p.T304fs	NM_001134831	NP_001128303	Q8N157	AHI1_HUMAN	Abelson helper integration site 1 isoform a	304						adherens junction|cilium|microtubule basal body				ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.239)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00904)|OV - Ovarian serous cystadenocarcinoma(155;0.00991)														---	---	---	---
FAM54A	113115	broad.mit.edu	37	6	136554647	136554647	+	Intron	DEL	A	-	-	rs2274141	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:136554647delA	uc010kgp.1	-						FAM54A_uc003qgt.1_Intron|FAM54A_uc003qgu.1_Intron	NM_001099286	NP_001092756			DUF729 domain containing 1											skin(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00228)|OV - Ovarian serous cystadenocarcinoma(155;0.00504)														---	---	---	---
FAM54A	113115	broad.mit.edu	37	6	136566111	136566111	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:136566111delT	uc010kgp.1	-						FAM54A_uc003qgt.1_Intron|FAM54A_uc003qgu.1_Intron	NM_001099286	NP_001092756			DUF729 domain containing 1											skin(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00228)|OV - Ovarian serous cystadenocarcinoma(155;0.00504)														---	---	---	---
MAP7	9053	broad.mit.edu	37	6	136681027	136681027	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:136681027delA	uc003qgz.2	-						MAP7_uc011edf.1_Intron|MAP7_uc011edg.1_Intron|MAP7_uc010kgu.2_Intron|MAP7_uc011edh.1_Intron|MAP7_uc010kgv.2_Intron|MAP7_uc010kgs.2_Intron|MAP7_uc011edi.1_Intron|MAP7_uc010kgq.1_Intron|MAP7_uc003qha.1_Intron	NM_003980	NP_003971			microtubule-associated protein 7						establishment or maintenance of cell polarity|microtubule cytoskeleton organization|protein localization in plasma membrane|response to osmotic stress	basolateral plasma membrane|microtubule|microtubule associated complex|nucleus|perinuclear region of cytoplasm	receptor binding|structural molecule activity				0	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00199)|OV - Ovarian serous cystadenocarcinoma(155;0.00643)														---	---	---	---
MAP3K5	4217	broad.mit.edu	37	6	136878762	136878766	+	3'UTR	DEL	TTTTA	-	-	rs71769549		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:136878762_136878766delTTTTA	uc003qhc.2	-	30					MAP3K5_uc011edj.1_3'UTR	NM_005923	NP_005914			mitogen-activated protein kinase kinase kinase						activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			ovary(2)|skin(2)|lung(1)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)														---	---	---	---
CITED2	10370	broad.mit.edu	37	6	139694831	139694831	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:139694831delG	uc003qip.1	-	2	495	c.251delC	c.(250-252)CCGfs	p.P84fs		NM_006079	NP_006070	Q99967	CITE2_HUMAN	Cbp/p300-interacting transactivator, with	84					adrenal cortex formation|anti-apoptosis|cell proliferation|determination of left/right symmetry|heart development|liver development|negative regulation of cell migration|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell cycle|positive regulation of cell-cell adhesion|positive regulation of male gonad development|positive regulation of peroxisome proliferator activated receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of organ formation|response to estrogen stimulus|response to fluid shear stress|response to hypoxia|sex determination	cytoplasm|nuclear chromatin|nucleus	chromatin binding|LBD domain binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity				0	Breast(32;0.226)			GBM - Glioblastoma multiforme(68;0.000171)|OV - Ovarian serous cystadenocarcinoma(155;0.00134)														---	---	---	---
PEX3	8504	broad.mit.edu	37	6	143806092	143806092	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:143806092delA	uc003qjl.2	+							NM_003630	NP_003621			peroxisomal biogenesis factor 3						protein import into peroxisome membrane|transmembrane transport	integral to peroxisomal membrane	protein binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(155;5.73e-06)|GBM - Glioblastoma multiforme(68;0.0117)														---	---	---	---
PHACTR2	9749	broad.mit.edu	37	6	144104469	144104469	+	Intron	DEL	A	-	-	rs1012753	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:144104469delA	uc003qjq.3	+						PHACTR2_uc010khh.2_Intron|PHACTR2_uc010khi.2_Intron|PHACTR2_uc003qjr.3_Intron	NM_014721	NP_055536			phosphatase and actin regulator 2 isoform 3								actin binding|protein phosphatase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(155;1.58e-05)|GBM - Glioblastoma multiforme(68;0.0386)														---	---	---	---
UTRN	7402	broad.mit.edu	37	6	144796037	144796037	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:144796037delA	uc003qkt.2	+						UTRN_uc010khq.1_Intron	NM_007124	NP_009055			utrophin						muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)														---	---	---	---
UTRN	7402	broad.mit.edu	37	6	145093031	145093031	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:145093031delT	uc003qkt.2	+							NM_007124	NP_009055			utrophin						muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)														---	---	---	---
SHPRH	257218	broad.mit.edu	37	6	146255804	146255804	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:146255804delA	uc003qlf.2	-						SHPRH_uc003qld.2_Intron|SHPRH_uc003qle.2_Intron|SHPRH_uc003qlg.1_Intron|SHPRH_uc003qlh.2_5'Flank	NM_001042683	NP_001036148			SNF2 histone linker PHD RING helicase isoform a						DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)														---	---	---	---
SASH1	23328	broad.mit.edu	37	6	148865376	148865376	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:148865376delC	uc003qme.1	+	18	3245	c.2770delC	c.(2770-2772)CCCfs	p.P924fs	SASH1_uc011eeb.1_Frame_Shift_Del_p.P685fs|SASH1_uc003qmf.1_Frame_Shift_Del_p.P334fs	NM_015278	NP_056093	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	924							protein binding			central_nervous_system(1)	1		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)														---	---	---	---
LRP11	84918	broad.mit.edu	37	6	150147575	150147575	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:150147575delT	uc003qng.2	-						LRP11_uc003qnh.1_Intron	NM_032832	NP_116221			low density lipoprotein receptor-related protein							integral to membrane	receptor activity				0		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;4.56e-12)|GBM - Glioblastoma multiforme(68;0.225)														---	---	---	---
Unknown	0	broad.mit.edu	37	6	150825358	150825358	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:150825358delA								IYD (99594 upstream) : PLEKHG1 (95641 downstream)																																			---	---	---	---
MTHFD1L	25902	broad.mit.edu	37	6	151253910	151253911	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:151253910_151253911delAA	uc003qob.2	+						MTHFD1L_uc011een.1_Intron|MTHFD1L_uc011eeo.1_Intron|MTHFD1L_uc003qoc.2_Intron	NM_015440	NP_056255			methylenetetrahydrofolate dehydrogenase (NADP+						folic acid-containing compound biosynthetic process|formate metabolic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|protein homodimerization activity			ovary(3)|large_intestine(1)	4		Ovarian(120;0.128)		OV - Ovarian serous cystadenocarcinoma(155;8.7e-12)														---	---	---	---
C6orf97	80129	broad.mit.edu	37	6	151917439	151917439	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:151917439delA	uc003qol.2	+							NM_025059	NP_079335			hypothetical protein LOC80129												0		Ovarian(120;0.126)	BRCA - Breast invasive adenocarcinoma(37;0.111)	OV - Ovarian serous cystadenocarcinoma(155;1.48e-10)														---	---	---	---
SYNE1	23345	broad.mit.edu	37	6	152552705	152552706	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:152552705_152552706delAA	uc010kiw.2	-						SYNE1_uc010kiv.2_Intron|SYNE1_uc003qos.3_Intron|SYNE1_uc003qot.3_Intron|SYNE1_uc003qou.3_Intron	NM_182961	NP_892006			spectrin repeat containing, nuclear envelope 1						cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)											HNSCC(10;0.0054)			---	---	---	---
Unknown	0	broad.mit.edu	37	6	153603371	153603371	+	IGR	DEL	T	-	-	rs113533278		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:153603371delT								RGS17 (150982 upstream) : OPRM1 (728265 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	6	154037518	154037518	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:154037518delT								RGS17 (585129 upstream) : OPRM1 (294118 downstream)																																			---	---	---	---
NOX3	50508	broad.mit.edu	37	6	155761308	155761308	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:155761308delA	uc003qqm.2	-							NM_015718	NP_056533			NADPH oxidase 3								electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			ovary(1)	1		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)														---	---	---	---
TULP4	56995	broad.mit.edu	37	6	158882444	158882445	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:158882444_158882445delAA	uc003qrf.2	+						TULP4_uc011efo.1_Intron|TULP4_uc003qrg.2_Intron	NM_020245	NP_064630			tubby like protein 4 isoform 1						intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)														---	---	---	---
SYTL3	94120	broad.mit.edu	37	6	159129240	159129240	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:159129240delA	uc003qrp.2	+						SYTL3_uc011efp.1_Intron|SYTL3_uc003qro.2_Intron|SYTL3_uc003qrq.2_Intron|SYTL3_uc003qrr.2_Intron|SYTL3_uc003qrs.2_Intron|SYTL3_uc011efq.1_Intron	NM_001009991	NP_001009991			synaptotagmin-like 3						intracellular protein transport	endomembrane system|membrane	Rab GTPase binding				0		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.54e-17)|BRCA - Breast invasive adenocarcinoma(81;8.24e-06)														---	---	---	---
WTAP	9589	broad.mit.edu	37	6	160163106	160163106	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:160163106delT	uc003qsl.2	+						WTAP_uc010kjx.2_Intron|WTAP_uc003qsk.2_Intron|WTAP_uc003qsm.1_Intron|WTAP_uc003qsn.2_Intron	NM_004906	NP_004897			Wilms' tumour 1-associating protein isoform 1						cell cycle|mRNA processing|RNA splicing	nuclear membrane|nucleolus					0		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.75e-18)|BRCA - Breast invasive adenocarcinoma(81;5.93e-06)														---	---	---	---
IGF2R	3482	broad.mit.edu	37	6	160505862	160505862	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:160505862delT	uc003qta.2	+							NM_000876	NP_000867			insulin-like growth factor 2 receptor precursor						receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)														---	---	---	---
QKI	9444	broad.mit.edu	37	6	163987695	163987695	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:163987695delT	uc003qui.2	+						QKI_uc003que.2_3'UTR|QKI_uc003quf.2_3'UTR|QKI_uc003qug.2_3'UTR|QKI_uc003quh.2_3'UTR|QKI_uc003quj.2_Intron	NM_006775	NP_006766			quaking homolog, KH domain RNA binding isoform						mRNA processing|mRNA transport|regulation of translation|RNA splicing	cytoplasm|nucleus|plasma membrane	RNA binding|SH3 domain binding			large_intestine(1)|ovary(1)	2		Breast(66;5e-05)|Prostate(117;0.0235)|all_neural(5;0.0416)|Ovarian(120;0.0448)|Glioma(2;0.203)		all cancers(1;4.4e-46)|OV - Ovarian serous cystadenocarcinoma(33;6.91e-23)|GBM - Glioblastoma multiforme(1;2.94e-19)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|Kidney(3;0.000199)|KIRC - Kidney renal clear cell carcinoma(3;0.000234)														---	---	---	---
SFT2D1	113402	broad.mit.edu	37	6	166741915	166741916	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:166741915_166741916insT	uc003qux.2	-							NM_145169	NP_660152			SFT2 domain containing 1						protein transport|vesicle-mediated transport	integral to membrane				central_nervous_system(1)	1		Breast(66;0.000148)|Prostate(117;0.109)|Ovarian(120;0.199)		OV - Ovarian serous cystadenocarcinoma(33;2.63e-19)|BRCA - Breast invasive adenocarcinoma(81;4.92e-06)|GBM - Glioblastoma multiforme(31;4.58e-05)														---	---	---	---
LFNG	3955	broad.mit.edu	37	7	2566173	2566173	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:2566173delG	uc003smf.2	+						LFNG_uc003smg.2_Intron	NM_001040167	NP_001035257			lunatic fringe isoform a						organ morphogenesis	extracellular region|integral to Golgi membrane	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity				0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;2.54e-14)														---	---	---	---
SDK1	221935	broad.mit.edu	37	7	4218344	4218344	+	Intron	DEL	G	-	-	rs74496933	byFrequency;by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:4218344delG	uc003smx.2	+						SDK1_uc010kso.2_Intron|SDK1_uc003smy.2_Intron	NM_152744	NP_689957			sidekick 1 precursor						cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)														---	---	---	---
WIPI2	26100	broad.mit.edu	37	7	5232565	5232565	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:5232565delT	uc003snv.2	+						WIPI2_uc003snw.2_Intron|WIPI2_uc003snx.2_Intron|WIPI2_uc003sny.2_Intron|WIPI2_uc010ksv.2_Intron	NM_015610	NP_056425			WD repeat domain, phosphoinositide interacting 2						autophagic vacuole assembly	cytosol|PAS complex|pre-autophagosomal structure membrane	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding			ovary(2)	2		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0925)|OV - Ovarian serous cystadenocarcinoma(56;2.59e-14)														---	---	---	---
WIPI2	26100	broad.mit.edu	37	7	5270696	5270696	+	3'UTR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:5270696delA	uc003snv.2	+	13					WIPI2_uc003snw.2_3'UTR|WIPI2_uc003snx.2_3'UTR|WIPI2_uc003sny.2_3'UTR|WIPI2_uc010ksv.2_3'UTR|WIPI2_uc003soa.2_3'UTR|WIPI2_uc003sob.2_3'UTR	NM_015610	NP_056425			WD repeat domain, phosphoinositide interacting 2						autophagic vacuole assembly	cytosol|PAS complex|pre-autophagosomal structure membrane	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding			ovary(2)	2		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0925)|OV - Ovarian serous cystadenocarcinoma(56;2.59e-14)														---	---	---	---
PMS2	5395	broad.mit.edu	37	7	6036896	6036896	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:6036896delA	uc003spl.2	-						PMS2_uc003spj.2_Intron|PMS2_uc003spk.2_Intron|PMS2_uc011jwl.1_Intron|PMS2_uc010ktg.2_Intron|PMS2_uc010kte.2_Intron|PMS2_uc010ktf.1_Intron	NM_000535	NP_000526			PMS2 postmeiotic segregation increased 2 isoform						mismatch repair|reciprocal meiotic recombination|somatic hypermutation of immunoglobulin genes	MutLalpha complex	ATP binding|ATPase activity|endonuclease activity|protein binding|single base insertion or deletion binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;4.39e-15)				Mis|N|F			colorectal|endometrial|ovarian|medulloblastoma|glioma		Direct_reversal_of_damage|MMR	Lynch_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				---	---	---	---
EIF2AK1	27102	broad.mit.edu	37	7	6089528	6089528	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:6089528delT	uc003spp.2	-						EIF2AK1_uc003spq.2_Intron|EIF2AK1_uc011jwm.1_Intron	NM_014413	NP_055228			eukaryotic translation initiation factor 2-alpha						negative regulation of hemoglobin biosynthetic process|negative regulation of translational initiation by iron|protein autophosphorylation|response to external stimulus|response to stress	cytoplasm	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|heme binding|protein homodimerization activity			upper_aerodigestive_tract(1)|stomach(1)|lung(1)|central_nervous_system(1)	4		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.106)|OV - Ovarian serous cystadenocarcinoma(56;5.22e-14)														---	---	---	---
C7orf26	79034	broad.mit.edu	37	7	6633948	6633948	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:6633948delT	uc003sqo.1	+						C7orf26_uc003sqp.1_Intron|C7orf26_uc003sqq.1_Intron	NM_024067	NP_076972			hypothetical protein LOC79034											ovary(1)	1		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)														---	---	---	---
C7orf28B	221960	broad.mit.edu	37	7	6864191	6864191	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:6864191delA	uc003sqx.1	-						C7orf28B_uc011jxd.1_Intron|C7orf28B_uc003sqy.1_Intron	NM_198097	NP_932765			hypothetical protein LOC221960							lysosomal membrane					0		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)														---	---	---	---
MIOS	54468	broad.mit.edu	37	7	7625576	7625576	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:7625576delT	uc003srf.2	+						MIOS_uc003srg.2_Intron|MIOS_uc010ktq.2_Intron	NM_019005	NP_061878			missing oocyte, meiosis regulator, homolog												0																		---	---	---	---
ICA1	3382	broad.mit.edu	37	7	8183660	8183660	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:8183660delA	uc003srm.2	-						ICA1_uc010ktr.2_Intron|ICA1_uc003srl.2_Intron|ICA1_uc003srn.3_Intron|ICA1_uc003srp.3_Intron|ICA1_uc010kts.2_Intron|ICA1_uc003srq.2_Intron|ICA1_uc003srr.2_Intron|ICA1_uc003sro.3_Intron	NM_022307	NP_071682			islet cell autoantigen 1						neurotransmitter transport	cell junction|cytosol|Golgi membrane|nucleus|secretory granule membrane|synaptic vesicle membrane|transport vesicle membrane				central_nervous_system(1)	1		Ovarian(82;0.0612)		UCEC - Uterine corpus endometrioid carcinoma (126;0.246)														---	---	---	---
Unknown	0	broad.mit.edu	37	7	10491542	10491542	+	IGR	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:10491542delG								PER4 (816095 upstream) : NDUFA4 (481273 downstream)																																			---	---	---	---
NDUFA4	4697	broad.mit.edu	37	7	10979407	10979407	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:10979407delT	uc003srx.1	-							NM_002489	NP_002480			NADH dehydrogenase (ubiquinone) 1 alpha						mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity				0				UCEC - Uterine corpus endometrioid carcinoma (126;0.177)	NADH(DB00157)													---	---	---	---
PHF14	9678	broad.mit.edu	37	7	11022426	11022426	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:11022426delA	uc003sry.1	+	3	975	c.540delA	c.(538-540)CCAfs	p.P180fs	PHF14_uc011jxi.1_Intron|PHF14_uc003srz.2_Frame_Shift_Del_p.P180fs|PHF14_uc011jxj.1_Intron	NM_014660	NP_055475	O94880	PHF14_HUMAN	PHD finger protein 14 isoform 2	180							zinc ion binding	p.K182fs*19(1)		kidney(2)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.205)														---	---	---	---
ISPD	729920	broad.mit.edu	37	7	16248899	16248904	+	Intron	DEL	TTTTTT	-	-	rs34795937		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:16248899_16248904delTTTTTT	uc010ktx.2	-						ISPD_uc010kty.2_Intron|uc003stf.2_5'Flank	NM_001101426	NP_001094896			notch1-induced protein isoform a						isoprenoid biosynthetic process		nucleotidyltransferase activity			ovary(1)	1															Multiple Myeloma(15;0.18)			---	---	---	---
Unknown	0	broad.mit.edu	37	7	17125263	17125263	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:17125263delT								AGR3 (203650 upstream) : AHR (213013 downstream)																																			---	---	---	---
ITGB8	3696	broad.mit.edu	37	7	20449395	20449395	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:20449395delA	uc003suu.2	+	13	2886	c.2181delA	c.(2179-2181)TCAfs	p.S727fs	ITGB8_uc011jyh.1_Frame_Shift_Del_p.S592fs	NM_002214	NP_002205	P26012	ITB8_HUMAN	integrin, beta 8 precursor	727	Cytoplasmic (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|placenta blood vessel development	integrin complex	protein binding|receptor activity			skin(3)	3																		---	---	---	---
DNAH11	8701	broad.mit.edu	37	7	21747481	21747482	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:21747481_21747482insT	uc003svc.2	+							NM_003777	NP_003768			dynein, axonemal, heavy chain 11						microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15														Kartagener_syndrome				---	---	---	---
OSBPL3	26031	broad.mit.edu	37	7	24844071	24844071	+	Intron	DEL	A	-	-	rs71815782		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:24844071delA	uc003sxf.2	-						OSBPL3_uc003sxd.2_Intron|OSBPL3_uc003sxe.2_Intron|OSBPL3_uc003sxg.2_Intron|OSBPL3_uc003sxh.2_Intron|OSBPL3_uc003sxi.2_Intron	NM_015550	NP_056365			oxysterol-binding protein-like protein 3 isoform						lipid transport		lipid binding|protein binding			skin(1)	1																		---	---	---	---
HNRNPA2B1	3181	broad.mit.edu	37	7	26237495	26237495	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:26237495delA	uc003sxr.3	-						HNRNPA2B1_uc003sxs.3_Intron	NM_031243	NP_112533			heterogeneous nuclear ribonucleoprotein A2/B1						RNA transport	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|protein binding|RNA binding|single-stranded telomeric DNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3								T	ETV1	prostate								---	---	---	---
HOXA2	3199	broad.mit.edu	37	7	27140390	27140390	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:27140390delA	uc003syh.2	-	2	1361	c.1086delT	c.(1084-1086)TTTfs	p.F362fs		NM_006735	NP_006726	O43364	HXA2_HUMAN	homeobox A2	362						nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2																		---	---	---	---
HOXA4	3201	broad.mit.edu	37	7	27170396	27170396	+	5'UTR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:27170396delT	uc003sym.3	-	1						NM_002141	NP_002132			homeobox A4							nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	7	27308926	27308926	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:27308926delT								EVX1 (22734 upstream) : HIBADH (256137 downstream)																																			---	---	---	---
CPVL	54504	broad.mit.edu	37	7	29111459	29111459	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:29111459delT	uc003szv.2	-	9	913	c.794delA	c.(793-795)AAGfs	p.K265fs	CPVL_uc003szw.2_Frame_Shift_Del_p.K265fs|CPVL_uc003szx.2_Frame_Shift_Del_p.K265fs	NM_031311	NP_112601	Q9H3G5	CPVL_HUMAN	serine carboxypeptidase vitellogenic-like	265					proteolysis		protein binding|serine-type carboxypeptidase activity			ovary(2)	2																		---	---	---	---
GARS	2617	broad.mit.edu	37	7	30662267	30662267	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:30662267delT	uc003tbm.2	+							NM_002047	NP_002038			glycyl-tRNA synthetase						cell death|diadenosine tetraphosphate biosynthetic process|glycyl-tRNA aminoacylation	cytosol|mitochondrial matrix|soluble fraction	ATP binding|glycine-tRNA ligase activity|protein dimerization activity			ovary(1)	1					Glycine(DB00145)													---	---	---	---
CCDC129	223075	broad.mit.edu	37	7	31609355	31609355	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:31609355delT	uc003tcj.1	+						CCDC129_uc011kad.1_Intron|CCDC129_uc003tci.1_Intron|CCDC129_uc011kae.1_Intron|CCDC129_uc003tck.1_Intron	NM_194300	NP_919276			coiled-coil domain containing 129												0																		---	---	---	---
AVL9	23080	broad.mit.edu	37	7	32582583	32582583	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:32582583delT	uc003tcv.1	+						AVL9_uc011kai.1_Intron|AVL9_uc010kwj.1_5'Flank	NM_015060	NP_055875			AVL9 homolog (S. cerevisiase)							integral to membrane					0																		---	---	---	---
AVL9	23080	broad.mit.edu	37	7	32591218	32591220	+	Intron	DEL	TTT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:32591218_32591220delTTT	uc003tcv.1	+						AVL9_uc011kai.1_Intron|AVL9_uc010kwj.1_Intron	NM_015060	NP_055875			AVL9 homolog (S. cerevisiase)							integral to membrane					0																		---	---	---	---
AVL9	23080	broad.mit.edu	37	7	32612708	32612708	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:32612708delT	uc003tcv.1	+						AVL9_uc011kai.1_Intron|AVL9_uc010kwj.1_Intron	NM_015060	NP_055875			AVL9 homolog (S. cerevisiase)							integral to membrane					0																		---	---	---	---
AVL9	23080	broad.mit.edu	37	7	32678981	32678981	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:32678981delA	uc011kai.1	+						uc003tcw.2_Intron	NM_015060	NP_055875			AVL9 homolog (S. cerevisiase)							integral to membrane					0																		---	---	---	---
AVL9	23080	broad.mit.edu	37	7	32958071	32958071	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:32958071delT	uc011kai.1	+						RP9P_uc003tdc.2_Intron|RP9P_uc003tdd.2_Intron|RP9P_uc011kaj.1_Intron	NM_015060	NP_055875			AVL9 homolog (S. cerevisiase)							integral to membrane					0																		---	---	---	---
DPY19L2P1	554236	broad.mit.edu	37	7	35161005	35161005	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:35161005delA	uc003teq.1	-						DPY19L2P1_uc003tep.1_Intron|DPY19L2P1_uc010kwz.1_Intron					RecName: Full=Protein dpy-19 homolog 2-like 2; AltName: Full=Dpy-19-like protein 2 pseudogene 2;												0																		---	---	---	---
DPY19L2P1	554236	broad.mit.edu	37	7	35209315	35209315	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:35209315delA	uc003teq.1	-											RecName: Full=Protein dpy-19 homolog 2-like 2; AltName: Full=Dpy-19-like protein 2 pseudogene 2;												0																		---	---	---	---
DPY19L2P1	554236	broad.mit.edu	37	7	35218857	35218857	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:35218857delA	uc003teq.1	-											RecName: Full=Protein dpy-19 homolog 2-like 2; AltName: Full=Dpy-19-like protein 2 pseudogene 2;												0																		---	---	---	---
Unknown	0	broad.mit.edu	37	7	35997695	35997695	+	IGR	DEL	C	-	-	rs11320725		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:35997695delC								SEPT7 (52780 upstream) : EEPD1 (195141 downstream)																																			---	---	---	---
URGCP	55665	broad.mit.edu	37	7	43921074	43921082	+	Intron	DEL	TTTTTTTTT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:43921074_43921082delTTTTTTTTT	uc003tiw.2	-						URGCP_uc003tiu.2_Intron|URGCP_uc003tiv.2_Intron|URGCP_uc003tix.2_Intron|URGCP_uc003tiy.2_Intron|URGCP_uc003tiz.2_Intron|URGCP_uc011kbj.1_Intron	NM_001077663	NP_001071131			up-regulated gene 4 isoform 3						cell cycle	centrosome|nucleus	GTP binding			ovary(2)|liver(1)|skin(1)	4																		---	---	---	---
Unknown	0	broad.mit.edu	37	7	44628465	44628465	+	IGR	DEL	G	-	-	rs217352	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:44628465delG								TMED4 (6638 upstream) : OGDH (17706 downstream)																																			---	---	---	---
OGDH	4967	broad.mit.edu	37	7	44747227	44747228	+	Frame_Shift_Ins	INS	-	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:44747227_44747228insC	uc003tln.2	+	22	2952_2953	c.2843_2844insC	c.(2842-2844)TACfs	p.Y948fs	OGDH_uc011kbx.1_Frame_Shift_Ins_p.Y944fs|OGDH_uc011kby.1_Frame_Shift_Ins_p.Y798fs|OGDH_uc003tlp.2_Frame_Shift_Ins_p.Y959fs|OGDH_uc011kbz.1_Frame_Shift_Ins_p.Y743fs	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	948					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)													---	---	---	---
HUS1	3364	broad.mit.edu	37	7	48018514	48018514	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:48018514delA	uc003tod.1	-						HUS1_uc003toe.1_Intron|HUS1_uc011kce.1_Intron	NM_004507	NP_004498			HUS1 checkpoint protein						DNA damage checkpoint|DNA replication	Golgi apparatus|nucleolus|nucleoplasm	protein binding			ovary(2)|lung(2)|kidney(1)	5		Breast(660;0.00139)											Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					---	---	---	---
SUN3	256979	broad.mit.edu	37	7	48045524	48045524	+	Intron	DEL	T	-	-	rs80067951		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:48045524delT	uc003tof.2	-						SUN3_uc010kyq.2_Intron|SUN3_uc003tog.2_Intron|SUN3_uc011kcf.1_Intron	NM_152782	NP_689995			Sad1 and UNC84 domain containing 1							integral to membrane				central_nervous_system(1)	1																		---	---	---	---
ABCA13	154664	broad.mit.edu	37	7	48467345	48467345	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:48467345delT	uc003toq.2	+						ABCA13_uc010kys.1_Intron|ABCA13_uc010kyt.1_Intron	NM_152701	NP_689914			ATP binding cassette, sub-family A (ABC1),						transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10																		---	---	---	---
Unknown	0	broad.mit.edu	37	7	56699457	56699457	+	IGR	DEL	A	-	-	rs78077053		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:56699457delA								DKFZp434L192 (134480 upstream) : ZNF479 (487871 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	7	65150817	65150818	+	Intron	DEL	CC	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:65150817_65150818delCC	uc003tud.1	-						INTS4L2_uc003tue.2_Intron					Homo sapiens hypothetical LOC441242, mRNA (cDNA clone MGC:87648 IMAGE:5267764), complete cds.																														---	---	---	---
SBDS	51119	broad.mit.edu	37	7	66456003	66456004	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:66456003_66456004insA	uc003tvm.1	-							NM_016038	NP_057122			Shwachman-Bodian-Diamond syndrome protein						bone marrow development|bone mineralization|leukocyte chemotaxis|mature ribosome assembly|mitotic spindle stabilization|positive regulation of translation|ribosomal large subunit biogenesis|rRNA processing	cytoplasm|nucleolus|nucleoplasm|spindle pole	microtubule binding|ribosome binding|rRNA binding			ovary(1)	1								Gene Conversion			AML|MDS			Shwachman-Diamond_syndrome				---	---	---	---
AUTS2	26053	broad.mit.edu	37	7	70256077	70256077	+	3'UTR	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:70256077delG	uc003tvw.3	+	19					AUTS2_uc003tvx.3_3'UTR|AUTS2_uc011keg.1_3'UTR	NM_015570	NP_056385			autism susceptibility candidate 2 isoform 1											ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)														---	---	---	---
POM121	9883	broad.mit.edu	37	7	72397426	72397427	+	Frame_Shift_Ins	INS	-	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:72397426_72397427insC	uc003twk.2	+	3	947_948	c.947_948insC	c.(946-948)CTCfs	p.L316fs	POM121_uc003twj.2_Frame_Shift_Ins_p.L51fs|POM121_uc010lam.1_Frame_Shift_Ins_p.L51fs	NM_172020	NP_742017	Q96HA1	P121A_HUMAN	nuclear pore membrane protein 121	316	Pore side (Potential).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore					0		Lung NSC(55;0.163)																---	---	---	---
TRIM50	135892	broad.mit.edu	37	7	72729267	72729267	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:72729267delA	uc010lbd.1	-						FKBP6_uc003twz.2_Intron|TRIM50_uc003txy.1_Intron|TRIM50_uc003txz.1_Intron	NM_178125	NP_835226			tripartite motif protein 50A							cytoplasm|intracellular membrane-bounded organelle	ligase activity|zinc ion binding			skin(1)	1																		---	---	---	---
GTF2I	2969	broad.mit.edu	37	7	74105135	74105135	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:74105135delT	uc003uau.2	+						GTF2I_uc003uat.2_Intron|GTF2I_uc003uav.2_Intron|GTF2I_uc003uaw.2_Intron|GTF2I_uc003uay.2_Intron|GTF2I_uc003uax.2_Intron	NM_032999	NP_127492			general transcription factor IIi isoform 1						negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0																		---	---	---	---
HIP1	3092	broad.mit.edu	37	7	75182913	75182913	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:75182913delT	uc003uds.1	-						HIP1_uc011kfz.1_Intron	NM_005338	NP_005329			huntingtin interacting protein 1						activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			lung(3)|pancreas(2)|ovary(1)|breast(1)|central_nervous_system(1)	8								T	PDGFRB	CMML								---	---	---	---
PTPN12	5782	broad.mit.edu	37	7	77240237	77240238	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:77240237_77240238insT	uc003ugh.2	+						PTPN12_uc011kgp.1_Intron|PTPN12_uc011kgq.1_Intron|PTPN12_uc010lds.2_Intron	NM_002835	NP_002826			protein tyrosine phosphatase, non-receptor type							soluble fraction	non-membrane spanning protein tyrosine phosphatase activity|SH3 domain binding			ovary(1)|breast(1)|pancreas(1)	3																		---	---	---	---
PTPN12	5782	broad.mit.edu	37	7	77247668	77247669	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:77247668_77247669delTT	uc003ugh.2	+						PTPN12_uc011kgp.1_Intron|PTPN12_uc011kgq.1_Intron|PTPN12_uc010lds.2_Intron	NM_002835	NP_002826			protein tyrosine phosphatase, non-receptor type							soluble fraction	non-membrane spanning protein tyrosine phosphatase activity|SH3 domain binding			ovary(1)|breast(1)|pancreas(1)	3																		---	---	---	---
SEMA3C	10512	broad.mit.edu	37	7	80427555	80427555	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:80427555delA	uc003uhj.2	-						SEMA3C_uc011kgw.1_Intron|SEMA3C_uc011kgx.1_Intron	NM_006379	NP_006370			semaphorin 3C precursor						immune response|response to drug	membrane	receptor activity			ovary(1)	1																		---	---	---	---
HGF	3082	broad.mit.edu	37	7	81359190	81359190	+	Intron	DEL	T	-	-	rs5745685		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:81359190delT	uc003uhl.2	-						HGF_uc003uhm.2_Intron	NM_000601	NP_000592			hepatocyte growth factor isoform 1						epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4																		---	---	---	---
PCLO	27445	broad.mit.edu	37	7	82582694	82582694	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:82582694delT	uc003uhx.2	-	5	7864	c.7575delA	c.(7573-7575)AAAfs	p.K2525fs	PCLO_uc003uhv.2_Frame_Shift_Del_p.K2525fs|PCLO_uc010lec.2_5'Flank	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	2456	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7																		---	---	---	---
PCLO	27445	broad.mit.edu	37	7	82585204	82585204	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:82585204delT	uc003uhx.2	-	5	5354	c.5065delA	c.(5065-5067)ACAfs	p.T1689fs	PCLO_uc003uhv.2_Frame_Shift_Del_p.T1689fs	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1620					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7																		---	---	---	---
DMTF1	9988	broad.mit.edu	37	7	86823978	86823978	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:86823978delT	uc003uih.2	+						DMTF1_uc003uii.2_Intron|DMTF1_uc003uij.2_Intron|DMTF1_uc011khb.1_Intron|DMTF1_uc003uik.2_Intron|DMTF1_uc003uil.2_Intron|DMTF1_uc003uin.2_Intron	NM_001142327	NP_001135799			cyclin D binding myb-like transcription factor 1						cell cycle	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(14;0.0058)																	---	---	---	---
CROT	54677	broad.mit.edu	37	7	87020765	87020765	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:87020765delT	uc003uit.2	+						CROT_uc003uiu.2_Intron	NM_021151	NP_066974			peroxisomal carnitine O-octanoyltransferase						fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|transport	peroxisomal matrix	carnitine O-octanoyltransferase activity			ovary(2)|lung(1)	3	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)				L-Carnitine(DB00583)													---	---	---	---
SLC25A40	55972	broad.mit.edu	37	7	87485473	87485473	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:87485473delA	uc003uje.2	-							NM_018843	NP_061331			mitochondrial carrier family protein						transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			haematopoietic_and_lymphoid_tissue(1)	1	Esophageal squamous(14;0.00202)																	---	---	---	---
ADAM22	53616	broad.mit.edu	37	7	87772153	87772153	+	Intron	DEL	A	-	-	rs144525827		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:87772153delA	uc003ujn.2	+						ADAM22_uc003ujk.1_Intron|ADAM22_uc003ujl.1_Intron|ADAM22_uc003ujm.2_Intron|ADAM22_uc003ujo.2_Intron|ADAM22_uc003ujp.1_Intron	NM_021723	NP_068369			ADAM metallopeptidase domain 22 isoform 1						cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)															---	---	---	---
CDK14	5218	broad.mit.edu	37	7	90233649	90233649	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:90233649delA	uc003uky.2	+						CDK14_uc003ukt.1_Intron|CDK14_uc003ukv.1_Intron|CDK14_uc003uku.1_Intron|CDK14_uc003ukx.1_Intron	NM_012395	NP_036527			PFTAIRE protein kinase 1						cell division|G2/M transition of mitotic cell cycle|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane	ATP binding|cyclin binding|cyclin-dependent protein kinase activity			lung(3)|ovary(1)	4																		---	---	---	---
CDK14	5218	broad.mit.edu	37	7	90747315	90747316	+	Intron	DEL	AA	-	-	rs803167	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:90747315_90747316delAA	uc003uky.2	+						CDK14_uc003ukz.1_Intron|CDK14_uc010les.1_Intron|CDK14_uc011khl.1_Intron	NM_012395	NP_036527			PFTAIRE protein kinase 1						cell division|G2/M transition of mitotic cell cycle|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane	ATP binding|cyclin binding|cyclin-dependent protein kinase activity			lung(3)|ovary(1)	4																		---	---	---	---
KRIT1	889	broad.mit.edu	37	7	91870165	91870165	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:91870165delA	uc003ulq.1	-						KRIT1_uc010lev.1_Intron|KRIT1_uc003ulr.1_Intron|KRIT1_uc003uls.1_Intron|KRIT1_uc003ult.1_Intron|KRIT1_uc003ulu.1_Intron|KRIT1_uc003ulv.1_Intron	NM_194456	NP_919438			krev interaction trapped 1 isoform 1						angiogenesis|cell redox homeostasis|negative regulation of angiogenesis|negative regulation of endothelial cell apoptosis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|regulation of establishment of cell polarity|small GTPase mediated signal transduction	cell-cell junction|cytoskeleton	protein binding|small GTPase regulator activity			ovary(2)|lung(1)	3	all_cancers(62;1.04e-09)|all_epithelial(64;5.75e-09)|Breast(17;0.00206)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)											Familial_Cerebral_Cavernous_Angioma				---	---	---	---
KRIT1	889	broad.mit.edu	37	7	91871512	91871512	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:91871512delA	uc003ulq.1	-						KRIT1_uc010lev.1_5'Flank|KRIT1_uc003ulr.1_Intron|KRIT1_uc003uls.1_Intron|KRIT1_uc003ult.1_Intron|KRIT1_uc003ulu.1_Intron|KRIT1_uc003ulv.1_Intron	NM_194456	NP_919438			krev interaction trapped 1 isoform 1						angiogenesis|cell redox homeostasis|negative regulation of angiogenesis|negative regulation of endothelial cell apoptosis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|regulation of establishment of cell polarity|small GTPase mediated signal transduction	cell-cell junction|cytoskeleton	protein binding|small GTPase regulator activity			ovary(2)|lung(1)	3	all_cancers(62;1.04e-09)|all_epithelial(64;5.75e-09)|Breast(17;0.00206)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)											Familial_Cerebral_Cavernous_Angioma				---	---	---	---
CCDC132	55610	broad.mit.edu	37	7	92932925	92932925	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:92932925delA	uc003umo.2	+						CCDC132_uc003umq.2_Intron|CCDC132_uc003ump.2_Intron|CCDC132_uc003umr.2_Intron|CCDC132_uc011khz.1_Intron	NM_017667	NP_060137			coiled-coil domain containing 132 isoform a												0	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)															---	---	---	---
CCDC132	55610	broad.mit.edu	37	7	92940603	92940603	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:92940603delA	uc003umo.2	+						CCDC132_uc003umq.2_Intron|CCDC132_uc003ump.2_Intron|CCDC132_uc003umr.2_Intron|CCDC132_uc011khz.1_Intron	NM_017667	NP_060137			coiled-coil domain containing 132 isoform a												0	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)															---	---	---	---
SGCE	8910	broad.mit.edu	37	7	94248281	94248281	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:94248281delA	uc003unl.2	-						SGCE_uc003unk.2_5'Flank|SGCE_uc003unm.2_Intron|SGCE_uc003unn.2_Intron|SGCE_uc011kic.1_Intron|SGCE_uc011kid.1_Intron	NM_003919	NP_003910			sarcoglycan, epsilon isoform 2						cell-matrix adhesion|muscle organ development	cytoplasm|cytoskeleton|integral to plasma membrane|sarcoglycan complex|sarcolemma	calcium ion binding			ovary(1)	1	all_cancers(62;8.26e-10)|all_epithelial(64;5.59e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)															---	---	---	---
Unknown	0	broad.mit.edu	37	7	98104875	98104875	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:98104875delA								BAIAP2L1 (74448 upstream) : NPTX2 (141722 downstream)																																			---	---	---	---
TMEM130	222865	broad.mit.edu	37	7	98457692	98457693	+	Intron	DEL	AA	-	-	rs67317732		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:98457692_98457693delAA	uc003upo.2	-						TMEM130_uc011kiq.1_Intron|TMEM130_uc011kir.1_Intron|TMEM130_uc003upn.2_Intron	NM_001134450	NP_001127922			transmembrane protein 130 isoform a							Golgi membrane|integral to membrane				ovary(1)|central_nervous_system(1)	2	all_cancers(62;4.05e-09)|all_epithelial(64;2.62e-09)|Lung NSC(181;0.01)|all_lung(186;0.0115)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)															---	---	---	---
TRRAP	8295	broad.mit.edu	37	7	98533362	98533362	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:98533362delA	uc003upp.2	+						TRRAP_uc011kis.1_Intron|TRRAP_uc003upr.2_Intron	NM_003496	NP_003487			transformation/transcription domain-associated						histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)															---	---	---	---
ARPC1A	10552	broad.mit.edu	37	7	98951411	98951411	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:98951411delT	uc003upx.1	+						ARPC1A_uc010lfu.1_Intron|ARPC1A_uc003upy.1_Intron|ARPC1A_uc011kit.1_Intron	NM_006409	NP_006400			actin related protein 2/3 complex subunit 1A						actin cytoskeleton organization|regulation of actin filament polymerization	actin cytoskeleton|cytoplasm	actin binding			ovary(1)	1	all_cancers(62;4.46e-09)|all_epithelial(64;3.44e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0258)		STAD - Stomach adenocarcinoma(171;0.215)															---	---	---	---
ZNF789	285989	broad.mit.edu	37	7	99081253	99081253	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99081253delA	uc003uqq.1	+						ZNF789_uc010lfw.1_Intron|ZNF789_uc003uqr.1_5'UTR	NM_213603	NP_998768			zinc finger protein 789 isoform 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)																	---	---	---	---
AP4M1	9179	broad.mit.edu	37	7	99701731	99701731	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99701731delT	uc003utb.3	+	7	768	c.560delT	c.(559-561)GTTfs	p.V187fs	MCM7_uc003usw.1_5'Flank|MCM7_uc003usx.1_5'Flank|AP4M1_uc011kjg.1_Frame_Shift_Del_p.V141fs|AP4M1_uc010lgl.1_Frame_Shift_Del_p.V187fs|AP4M1_uc003utc.3_Frame_Shift_Del_p.V194fs|AP4M1_uc010lgm.2_Frame_Shift_Del_p.V59fs|AP4M1_uc003utd.2_Frame_Shift_Del_p.V187fs|AP4M1_uc011kjh.1_Frame_Shift_Del_p.V139fs|AP4M1_uc003ute.3_5'UTR|AP4M1_uc003utf.3_Frame_Shift_Del_p.V59fs	NM_004722	NP_004713	O00189	AP4M1_HUMAN	adaptor-related protein complex 4, mu 1 subunit	187	MHD.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|coated pit|Golgi trans cisterna	transporter activity				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)																	---	---	---	---
PILRB	29990	broad.mit.edu	37	7	99943553	99943553	+	5'UTR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99943553delT	uc003uuk.2	+	4					PILRB_uc003uul.2_5'UTR	NM_013440	NP_038468			paired immunoglobulin-like type 2 receptor beta						activation of transmembrane receptor protein tyrosine kinase activity	integral to plasma membrane	protein binding|receptor activity				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)																	---	---	---	---
ZAN	7455	broad.mit.edu	37	7	100369721	100369721	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100369721delT	uc003uwj.2	+						ZAN_uc003uwk.2_Intron|ZAN_uc003uwl.2_Intron|ZAN_uc010lhh.2_Intron|ZAN_uc010lhi.2_Intron|ZAN_uc011kkd.1_Intron|ZAN_uc011kke.1_5'Flank	NM_003386	NP_003377			zonadhesin isoform 3						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)															---	---	---	---
AP1S1	1174	broad.mit.edu	37	7	100802405	100802406	+	Frame_Shift_Del	DEL	GG	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100802405_100802406delGG	uc003uxv.3	+	4	467_468	c.357_358delGG	c.(355-360)ATGGGGfs	p.M119fs		NM_001283	NP_001274	P61966	AP1S1_HUMAN	adaptor-related protein complex 1, sigma 1	119_120					intracellular protein transport|post-Golgi vesicle-mediated transport|receptor-mediated endocytosis|regulation of defense response to virus by virus|response to virus|viral reproduction	AP-1 adaptor complex|coated pit|cytosol|lysosomal membrane	protein binding|protein transporter activity				0	Lung NSC(181;0.168)|all_lung(186;0.215)																	---	---	---	---
PMPCB	9512	broad.mit.edu	37	7	102952082	102952082	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:102952082delT	uc003vbl.2	+						PMPCB_uc003vbk.1_Intron|PMPCB_uc003vbm.2_Intron|PMPCB_uc010liv.2_Intron|PMPCB_uc010liw.2_Intron|PMPCB_uc011kll.1_Intron|PMPCB_uc011klm.1_Intron	NM_004279	NP_004270			mitochondrial processing peptidase beta subunit						proteolysis	mitochondrial matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)	4																		---	---	---	---
SYPL1	6856	broad.mit.edu	37	7	105739760	105739760	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:105739760delA	uc003vdp.2	-						SYPL1_uc003vdo.2_Intron	NM_006754	NP_006745			synaptophysin-like 1 isoform a						synaptic transmission	cytoplasmic vesicle membrane|integral to plasma membrane|melanosome|synaptic vesicle	transporter activity				0																		---	---	---	---
SLC26A3	1811	broad.mit.edu	37	7	107414307	107414307	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:107414307delT	uc003ver.2	-						SLC26A3_uc003ves.2_Intron	NM_000111	NP_000102			solute carrier family 26, member 3						excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			ovary(3)|skin(1)	4																		---	---	---	---
PNPLA8	50640	broad.mit.edu	37	7	108119959	108119959	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:108119959delA	uc003vff.1	-						PNPLA8_uc003vfg.1_Intron|PNPLA8_uc003vfh.1_Intron|PNPLA8_uc003vfi.1_Intron|PNPLA8_uc003vfj.1_Intron|PNPLA8_uc003vfk.1_Intron	NM_015723	NP_056538			patatin-like phospholipase domain containing 8						fatty acid metabolic process|lipid catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|membrane fraction|perinuclear region of cytoplasm|peroxisomal membrane	ATP binding|calcium-independent phospholipase A2 activity|lysophospholipase activity			breast(2)	2																		---	---	---	---
IMMP2L	83943	broad.mit.edu	37	7	111034854	111034854	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:111034854delT	uc003vfq.1	-						IMMP2L_uc010ljr.1_Intron|IMMP2L_uc003vfr.2_Intron	NM_032549	NP_115938			IMP2 inner mitochondrial membrane protease-like						protein processing involved in protein targeting to mitochondrion|proteolysis	integral to membrane|mitochondrial inner membrane peptidase complex|nucleus	serine-type peptidase activity				0				UCEC - Uterine corpus endometrioid carcinoma (4;0.053)|Epithelial(3;2.27e-07)|all cancers(3;1.36e-05)|STAD - Stomach adenocarcinoma(3;0.00148)|KIRC - Kidney renal clear cell carcinoma(11;0.0339)|Lung(3;0.0375)|Kidney(11;0.0415)|LUSC - Lung squamous cell carcinoma(290;0.173)														---	---	---	---
IFRD1	3475	broad.mit.edu	37	7	112112570	112112570	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:112112570delT	uc003vgh.2	+						IFRD1_uc011kmn.1_Intron|IFRD1_uc003vgj.2_Intron|IFRD1_uc011kmo.1_Intron|IFRD1_uc011kmp.1_Intron|IFRD1_uc003vgk.2_Intron	NM_001007245	NP_001007246			interferon-related developmental regulator 1						multicellular organismal development|myoblast cell fate determination		binding			kidney(1)|central_nervous_system(1)	2																		---	---	---	---
MET	4233	broad.mit.edu	37	7	116395377	116395378	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:116395377_116395378insT	uc003vij.2	+						MET_uc010lkh.2_Intron|MET_uc011knc.1_Intron|MET_uc011knd.1_Intron|MET_uc011kne.1_Intron|MET_uc011knf.1_Intron|MET_uc011kng.1_Intron|MET_uc011knh.1_Intron|MET_uc011kni.1_Intron|MET_uc011knj.1_Intron	NM_000245	NP_000236			met proto-oncogene isoform b precursor						axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			upper_aerodigestive_tract(63)|lung(41)|kidney(18)|NS(10)|ovary(5)|thyroid(4)|central_nervous_system(4)|stomach(3)|liver(3)|pleura(2)|large_intestine(2)|breast(2)|testis(1)|skin(1)	159	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)					Mis		papillary renal|head-neck squamous cell 	papillary renal			Hereditary_Papillary_Renal_Carcinoma_(type_1)				---	---	---	---
CAPZA2	830	broad.mit.edu	37	7	116538816	116538816	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:116538816delT	uc003vil.2	+						CAPZA2_uc003vik.1_Intron|CAPZA2_uc011knk.1_Intron	NM_006136	NP_006127			capping protein (actin filament) muscle Z-line,						actin cytoskeleton organization|actin filament capping|blood coagulation|cellular component movement|innate immune response|protein complex assembly	cytosol|extracellular region|F-actin capping protein complex	actin binding				0	all_cancers(3;8.53e-08)|all_epithelial(6;7.79e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)		GBM - Glioblastoma multiforme(2;5.01e-06)|STAD - Stomach adenocarcinoma(10;0.000512)|all cancers(2;0.00326)															---	---	---	---
C7orf58	79974	broad.mit.edu	37	7	120776081	120776081	+	Intron	DEL	T	-	-	rs78822434		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:120776081delT	uc003vjq.3	+						C7orf58_uc003vjr.1_Intron|C7orf58_uc003vjs.3_Intron|C7orf58_uc003vjt.3_Intron	NM_024913	NP_079189			hypothetical protein LOC79974 isoform 1							endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)																	---	---	---	---
WNT16	51384	broad.mit.edu	37	7	120971879	120971879	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:120971879delG	uc003vjw.2	+	3	751	c.494delG	c.(493-495)TGGfs	p.W165fs	WNT16_uc003vjv.2_Frame_Shift_Del_p.W155fs|WNT16_uc010lkl.2_Intron	NM_057168	NP_476509	Q9UBV4	WNT16_HUMAN	wingless-type MMTV integration site family,	165					anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|keratinocyte differentiation|keratinocyte proliferation|negative regulation of cell death|optic cup formation involved in camera-type eye development|oxidative stress-induced premature senescence|positive regulation of gene expression|positive regulation of JNK cascade|positive regulation of phosphatidylinositol 3-kinase cascade|replicative senescence|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled binding|signal transducer activity			lung(2)|ovary(2)|large_intestine(1)	5	all_neural(327;0.117)																	---	---	---	---
FAM3C	10447	broad.mit.edu	37	7	121022812	121022812	+	Intron	DEL	A	-	-	rs77488516		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:121022812delA	uc003vjx.2	-						FAM3C_uc010lkm.2_Intron	NM_014888	NP_055703			family with sequence similarity 3, member C						multicellular organismal development	cytoplasmic membrane-bounded vesicle|extracellular region	cytokine activity				0	all_neural(327;0.117)																	---	---	---	---
CADPS2	93664	broad.mit.edu	37	7	122033704	122033704	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:122033704delA	uc010lkp.2	-						CADPS2_uc011knx.1_Intron|CADPS2_uc003vkg.3_Intron|CADPS2_uc010lkq.2_Intron	NM_017954	NP_060424			Ca2+-dependent activator protein for secretion 2						exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
SLC13A1	6561	broad.mit.edu	37	7	122759366	122759366	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:122759366delA	uc003vkm.2	-						SLC13A1_uc010lks.2_Intron	NM_022444	NP_071889			solute carrier family 13 (sodium/sulfate							integral to membrane|plasma membrane	sodium:sulfate symporter activity			ovary(2)	2					Succinic acid(DB00139)													---	---	---	---
Unknown	0	broad.mit.edu	37	7	126924059	126924064	+	IGR	DEL	GTGTGT	-	-	rs35016672		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:126924059_126924064delGTGTGT								GRM8 (30912 upstream) : ZNF800 (86290 downstream)																																			---	---	---	---
FSCN3	29999	broad.mit.edu	37	7	127233859	127233859	+	5'UTR	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:127233859delG	uc003vmd.1	+	1					FSCN3_uc003vmc.1_Intron|FSCN3_uc011kog.1_RNA|FSCN3_uc011koh.1_5'UTR|FSCN3_uc010llc.1_5'UTR	NM_020369	NP_065102			fascin 3							actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging			ovary(1)	1																		---	---	---	---
NRF1	4899	broad.mit.edu	37	7	129395139	129395139	+	3'UTR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:129395139delT	uc003voz.2	+	11					NRF1_uc003vpa.2_3'UTR|NRF1_uc011kpa.1_3'UTR|NRF1_uc003vpb.2_3'UTR	NM_005011	NP_005002			nuclear respiratory factor 1						generation of precursor metabolites and energy|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1																		---	---	---	---
ZC3HC1	51530	broad.mit.edu	37	7	129679185	129679185	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:129679185delA	uc003vpi.2	-						ZC3HC1_uc003vph.2_Intron|ZC3HC1_uc010lma.2_Intron	NM_016478	NP_057562			zinc finger, C3HC type 1						cell division|mitosis	nucleus	protein kinase binding|zinc ion binding				0	Melanoma(18;0.0435)																	---	---	---	---
TMEM209	84928	broad.mit.edu	37	7	129842518	129842518	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:129842518delT	uc003vpn.2	-						TMEM209_uc010lmc.1_Intron|TMEM209_uc003vpo.2_Intron	NM_032842	NP_116231			transmembrane protein 209							integral to membrane				ovary(2)|large_intestine(1)	3	Melanoma(18;0.0435)																	---	---	---	---
COPG2	26958	broad.mit.edu	37	7	130148870	130148870	+	Intron	DEL	A	-	-	rs77402405		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:130148870delA	uc003vqh.1	-							NM_012133	NP_036265			coatomer protein complex, subunit gamma 2						intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat	protein binding|structural molecule activity				0	Melanoma(18;0.0435)																	---	---	---	---
MKLN1	4289	broad.mit.edu	37	7	130927794	130927795	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:130927794_130927795delAA	uc011kpl.1	+							NM_001145354	NP_001138826			muskelin 1, intracellular mediator containing						signal transduction	cytoplasm	protein binding			breast(1)	1	Melanoma(18;0.162)																	---	---	---	---
STRA8	346673	broad.mit.edu	37	7	134929926	134929927	+	Intron	INS	-	AC	AC			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:134929926_134929927insAC	uc011kpx.1	+							NM_182489	NP_872295			STRA8						DNA replication|regulation of transcription, DNA-dependent	cytoplasm|nucleus					0																		---	---	---	---
NUP205	23165	broad.mit.edu	37	7	135256070	135256070	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:135256070delT	uc003vsw.2	+						NUP205_uc011kqa.1_Intron	NM_015135	NP_055950			nucleoporin 205kDa						carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6																		---	---	---	---
NUP205	23165	broad.mit.edu	37	7	135260952	135260953	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:135260952_135260953insT	uc003vsw.2	+						NUP205_uc011kqa.1_Intron	NM_015135	NP_055950			nucleoporin 205kDa						carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6																		---	---	---	---
NUP205	23165	broad.mit.edu	37	7	135287555	135287555	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:135287555delA	uc003vsw.2	+	18	2546	c.2515delA	c.(2515-2517)AAAfs	p.K839fs		NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	839					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6																		---	---	---	---
DGKI	9162	broad.mit.edu	37	7	137151696	137151696	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:137151696delA	uc003vtt.2	-						DGKI_uc003vtu.2_Intron	NM_004717	NP_004708			diacylglycerol kinase, iota						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3																		---	---	---	---
DGKI	9162	broad.mit.edu	37	7	137237501	137237504	+	Intron	DEL	AAAA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:137237501_137237504delAAAA	uc003vtt.2	-						DGKI_uc003vtu.2_Intron	NM_004717	NP_004708			diacylglycerol kinase, iota						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3																		---	---	---	---
JHDM1D	80853	broad.mit.edu	37	7	139829506	139829506	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:139829506delA	uc003vvm.2	-							NM_030647	NP_085150			jumonji C domain containing histone demethylase						midbrain development|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1	Melanoma(164;0.0142)																	---	---	---	---
BRAF	673	broad.mit.edu	37	7	140434620	140434621	+	Intron	INS	-	AAAG	AAAG	rs145368076	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:140434620_140434621insAAAG	uc003vwc.3	-							NM_004333	NP_004324			B-Raf						activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)		61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				---	---	---	---
MRPS33	51650	broad.mit.edu	37	7	140710177	140710177	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:140710177delA	uc003vwd.3	-						MRPS33_uc003vwe.3_Intron	NM_016071	NP_057155			mitochondrial ribosomal protein S33						translation	mitochondrial small ribosomal subunit	structural constituent of ribosome				0	Melanoma(164;0.00956)																	---	---	---	---
AGK	55750	broad.mit.edu	37	7	141311097	141311097	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:141311097delT	uc003vwi.2	+						AGK_uc011krg.1_Intron	NM_018238	NP_060708			acylglycerol kinase precursor						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway	mitochondrial membrane	acylglycerol kinase activity|ATP binding|diacylglycerol kinase activity|NAD+ kinase activity			ovary(1)|breast(1)	2	Melanoma(164;0.0171)																	---	---	---	---
TPK1	27010	broad.mit.edu	37	7	144532719	144532719	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:144532719delA	uc003weq.2	-						TPK1_uc003wer.2_Intron|TPK1_uc003wes.2_Intron	NM_022445	NP_071890			thiamin pyrophosphokinase 1 isoform a						thiamine diphosphate biosynthetic process	cytosol	ATP binding|kinase activity|thiamine diphosphokinase activity			ovary(2)	2					Thiamine(DB00152)													---	---	---	---
ZNF786	136051	broad.mit.edu	37	7	148771740	148771742	+	Intron	DEL	AAA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:148771740_148771742delAAA	uc003wfh.2	-						ZNF786_uc011kuk.1_Intron|ZNF786_uc003wfi.2_Intron	NM_152411	NP_689624			zinc finger protein 786						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|skin(1)	4	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)															---	---	---	---
ZNF212	7988	broad.mit.edu	37	7	148947139	148947139	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:148947139delT	uc003wfp.2	+							NM_012256	NP_036388			zinc finger protein 212						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			ovary(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)															---	---	---	---
GALNTL5	168391	broad.mit.edu	37	7	151684235	151684235	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:151684235delT	uc003wkp.2	+						GALNTL5_uc003wkq.2_Intron|GALNTL5_uc003wkr.2_Intron|GALNTL5_uc003wks.2_Intron|GALNTL5_uc010lqf.2_Intron	NM_145292	NP_660335			UDP-N-acetyl-alpha-D-galactosamine:polypeptide							Golgi membrane|integral to membrane	transferase activity, transferring glycosyl groups			ovary(2)	2	all_neural(206;0.187)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00427)	UCEC - Uterine corpus endometrioid carcinoma (81;0.18)|BRCA - Breast invasive adenocarcinoma(188;0.166)														---	---	---	---
MLL3	58508	broad.mit.edu	37	7	151945528	151945530	+	In_Frame_Del	DEL	TGC	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:151945528_151945530delTGC	uc003wla.2	-	14	2208_2210	c.1989_1991delGCA	c.(1987-1992)CAGCAA>CAA	p.663_664QQ>Q		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	663_664	Potential.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)				N		medulloblastoma								---	---	---	---
ACTR3B	57180	broad.mit.edu	37	7	152549035	152549035	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:152549035delA	uc003wle.1	+						ACTR3B_uc003wlf.1_Intron|ACTR3B_uc003wlg.1_Intron|ACTR3B_uc011kvp.1_Intron	NM_020445	NP_065178			actin-related protein 3-beta isoform 1						regulation of actin filament polymerization	cell projection|cytoplasm|cytoskeleton	actin binding|ATP binding				0		all_hematologic(28;0.0592)|Prostate(32;0.191)	OV - Ovarian serous cystadenocarcinoma(82;0.0287)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0434)														---	---	---	---
RBM33	155435	broad.mit.edu	37	7	155473256	155473257	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:155473256_155473257delTT	uc010lqk.1	+						RBM33_uc003wme.2_Intron	NM_053043	NP_444271			RNA binding motif protein 33								nucleotide binding|RNA binding			ovary(1)	1	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)														---	---	---	---
LMBR1	64327	broad.mit.edu	37	7	156476636	156476636	+	3'UTR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:156476636delA	uc003wmw.3	-	17					LMBR1_uc003wmv.3_3'UTR|LMBR1_uc003wmx.3_3'UTR|LMBR1_uc010lqn.2_3'UTR|LMBR1_uc011kvx.1_3'UTR	NM_022458	NP_071903			limb region 1 protein							integral to membrane	receptor activity				0	Ovarian(565;0.218)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.208)														---	---	---	---
UBE3C	9690	broad.mit.edu	37	7	157046585	157046585	+	Intron	DEL	T	-	-	rs79641264		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:157046585delT	uc010lqs.2	+						UBE3C_uc003wni.3_Intron	NM_014671	NP_055486			ubiquitin protein ligase E3C						protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(2)|large_intestine(1)	5		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)														---	---	---	---
NCAPG2	54892	broad.mit.edu	37	7	158438335	158438335	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:158438335delA	uc003wnv.1	-						NCAPG2_uc010lqu.1_Intron|NCAPG2_uc003wnw.1_Intron|NCAPG2_uc003wnx.1_Intron|NCAPG2_uc011kwe.1_Intron|NCAPG2_uc011kwc.1_Intron|NCAPG2_uc011kwd.1_Intron	NM_017760	NP_060230			leucine zipper protein 5						cell division|chromosome condensation|mitosis	nucleus	methylated histone residue binding			ovary(1)|breast(1)|kidney(1)	3	Ovarian(565;0.152)	all_cancers(7;3.44e-11)|all_epithelial(9;3.05e-05)|all_hematologic(28;0.014)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.187)|STAD - Stomach adenocarcinoma(7;0.18)														---	---	---	---
Unknown	0	broad.mit.edu	37	7	159024963	159024963	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:159024963delT								VIPR2 (87314 upstream) : None (None downstream)																																			---	---	---	---
ARHGEF10	9639	broad.mit.edu	37	8	1817227	1817227	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:1817227delA	uc003wpr.2	+						ARHGEF10_uc003wpq.1_Intron|ARHGEF10_uc003wps.2_Intron|ARHGEF10_uc003wpt.2_Intron|ARHGEF10_uc010lrd.1_Intron|ARHGEF10_uc003wpu.2_Intron	NM_014629	NP_055444			Rho guanine nucleotide exchange factor 10						centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)														---	---	---	---
CSMD1	64478	broad.mit.edu	37	8	4808940	4808940	+	Intron	DEL	A	-	-	rs76437598	byFrequency;by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:4808940delA	uc011kwk.1	-							NM_033225	NP_150094			CUB and Sushi multiple domains 1 precursor							integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)														---	---	---	---
AGPAT5	55326	broad.mit.edu	37	8	6612540	6612540	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:6612540delA	uc003wqo.2	+						AGPAT5_uc011kwm.1_Intron	NM_018361	NP_060831			1-acylglycerol-3-phosphate O-acyltransferase 5						phospholipid biosynthetic process	integral to membrane|mitochondrion	1-acylglycerol-3-phosphate O-acyltransferase activity				0			STAD - Stomach adenocarcinoma(24;0.0578)	READ - Rectum adenocarcinoma(644;0.156)|COAD - Colon adenocarcinoma(149;0.191)														---	---	---	---
TNKS	8658	broad.mit.edu	37	8	9414303	9414303	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:9414303delG	uc003wss.2	+						TNKS_uc011kwv.1_Intron|uc003wsr.1_5'Flank	NM_003747	NP_003738			tankyrase, TRF1-interacting ankyrin-related						mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			lung(4)|ovary(2)|kidney(1)	7				COAD - Colon adenocarcinoma(149;0.0467)														---	---	---	---
TNKS	8658	broad.mit.edu	37	8	9583927	9583927	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:9583927delA	uc003wss.2	+						TNKS_uc011kww.1_Intron|TNKS_uc010lrs.1_Intron	NM_003747	NP_003738			tankyrase, TRF1-interacting ankyrin-related						mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			lung(4)|ovary(2)|kidney(1)	7				COAD - Colon adenocarcinoma(149;0.0467)														---	---	---	---
DLC1	10395	broad.mit.edu	37	8	12949030	12949030	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:12949030delA	uc003wwm.2	-						DLC1_uc003wwk.1_Intron|DLC1_uc003wwl.1_Intron|DLC1_uc011kxx.1_Intron	NM_182643	NP_872584			deleted in liver cancer 1 isoform 1						actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7																		---	---	---	---
VPS37A	137492	broad.mit.edu	37	8	17142235	17142235	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:17142235delT	uc003wxj.2	+						VPS37A_uc003wxk.2_Intron|VPS37A_uc003wxl.2_Intron	NM_152415	NP_689628			hepatocellular carcinoma related protein 1						cellular membrane organization|endosome transport|protein transport	centrosome|late endosome membrane|nucleus					0				Colorectal(111;0.0553)|COAD - Colon adenocarcinoma(73;0.212)														---	---	---	---
PCM1	5108	broad.mit.edu	37	8	17871605	17871607	+	Intron	DEL	AAA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:17871605_17871607delAAA	uc003wyi.3	+						PCM1_uc011kyh.1_Intron|PCM1_uc003wyj.3_Intron|PCM1_uc011kyi.1_Intron|PCM1_uc011kyj.1_Intron|PCM1_uc003wyk.3_Intron|PCM1_uc011kyk.1_Intron	NM_006197	NP_006188			pericentriolar material 1						centrosome organization|cilium assembly|G2/M transition of mitotic cell cycle|interkinetic nuclear migration|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome	centriolar satellite|cytosol|nuclear membrane|pericentriolar material	identical protein binding		PCM1/JAK2(30)	haematopoietic_and_lymphoid_tissue(30)|breast(4)|ovary(2)	36				Colorectal(111;0.0789)				T	RET|JAK2	papillary thyroid|CML|MPD								---	---	---	---
SLC39A14	23516	broad.mit.edu	37	8	22248227	22248227	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:22248227delT	uc003xbq.3	+						SLC39A14_uc011kzg.1_Intron|SLC39A14_uc003xbp.3_Intron|SLC39A14_uc011kzh.1_Intron	NM_001128431	NP_001121903			solute carrier family 39 (zinc transporter),							endoplasmic reticulum|Golgi apparatus|integral to membrane|lamellipodium|plasma membrane	zinc ion transmembrane transporter activity				0				Colorectal(74;0.019)|COAD - Colon adenocarcinoma(73;0.0731)														---	---	---	---
SLC25A37	51312	broad.mit.edu	37	8	23425655	23425655	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:23425655delT	uc003xdo.2	+						SLC25A37_uc003xdp.2_Intron|SLC25A37_uc010ltz.2_Intron|SLC25A37_uc003xdq.2_RNA|SLC25A37_uc003xdr.1_5'Flank	NM_016612	NP_057696			solute carrier family 25, member 37						ion transport|iron ion homeostasis	integral to membrane|mitochondrial inner membrane					0		Prostate(55;0.114)		Colorectal(74;0.0198)|COAD - Colon adenocarcinoma(73;0.0751)														---	---	---	---
DOCK5	80005	broad.mit.edu	37	8	25203373	25203373	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:25203373delT	uc003xeg.2	+						DOCK5_uc010luf.1_Intron|DOCK5_uc003xeh.1_Intron|DOCK5_uc003xei.2_Intron|DOCK5_uc003xej.2_Intron	NM_024940	NP_079216			dedicator of cytokinesis 5							cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)														---	---	---	---
DOCK5	80005	broad.mit.edu	37	8	25240127	25240127	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:25240127delT	uc003xeg.2	+						PPP2R2A_uc003xek.2_Intron|DOCK5_uc003xei.2_Intron|DOCK5_uc003xej.2_Intron	NM_024940	NP_079216			dedicator of cytokinesis 5							cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)														---	---	---	---
KIF13B	23303	broad.mit.edu	37	8	28929788	28929788	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:28929788delC	uc003xhh.3	-	39	4626	c.4567delG	c.(4567-4569)GCCfs	p.A1523fs	KIF13B_uc011laz.1_Frame_Shift_Del_p.A42fs	NM_015254	NP_056069	Q9NQT8	KI13B_HUMAN	kinesin family member 13B	1523					microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding				0		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)														---	---	---	---
KIF13B	23303	broad.mit.edu	37	8	28956895	28956895	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:28956895delT	uc003xhh.3	-						KIF13B_uc011laz.1_5'Flank	NM_015254	NP_056069			kinesin family member 13B						microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding				0		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)														---	---	---	---
KIF13B	23303	broad.mit.edu	37	8	28989772	28989772	+	Intron	DEL	A	-	-	rs112826611		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:28989772delA	uc003xhh.3	-						uc003xhi.1_Intron	NM_015254	NP_056069			kinesin family member 13B						microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding				0		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)														---	---	---	---
WRN	7486	broad.mit.edu	37	8	30938371	30938371	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:30938371delT	uc003xio.3	+						WRN_uc011lbd.1_5'Flank|WRN_uc011lbe.1_5'Flank	NM_000553	NP_000544			Werner syndrome protein						base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			ovary(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	7		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)				Mis|N|F|S			osteosarcoma|meningioma|others		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Werner_syndrome				---	---	---	---
KCNU1	157855	broad.mit.edu	37	8	36779849	36779849	+	Intron	DEL	A	-	-	rs68098747		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:36779849delA	uc010lvw.2	+						KCNU1_uc003xjw.2_Intron	NM_001031836	NP_001027006			potassium channel, subfamily U, member 1							voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)														---	---	---	---
ADAM32	203102	broad.mit.edu	37	8	39128387	39128387	+	Intron	DEL	C	-	-	rs4733994	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:39128387delC	uc003xmt.3	+						ADAM32_uc011lch.1_Intron|ADAM32_uc003xmu.3_Intron|ADAM32_uc003xmv.2_Intron	NM_145004	NP_659441			a disintegrin and metalloprotease domain 32						proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)|kidney(1)	3		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)															---	---	---	---
Unknown	0	broad.mit.edu	37	8	40266001	40266002	+	IGR	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:40266001_40266002insT								C8orf4 (253180 upstream) : ZMAT4 (122114 downstream)																																			---	---	---	---
MYST3	7994	broad.mit.edu	37	8	41832349	41832349	+	Intron	DEL	A	-	-	rs75568702		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:41832349delA	uc010lxb.2	-						MYST3_uc010lxc.2_Intron|MYST3_uc003xon.3_Intron|MYST3_uc010lxd.2_Intron	NM_001099412	NP_001092882			MYST histone acetyltransferase (monocytic						histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)															---	---	---	---
Unknown	0	broad.mit.edu	37	8	41926441	41926441	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:41926441delA								MYST3 (16936 upstream) : AP3M2 (84023 downstream)																																			---	---	---	---
SLC20A2	6575	broad.mit.edu	37	8	42342439	42342439	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:42342439delA	uc010lxl.2	-						SLC20A2_uc010lxm.2_Intron|SLC20A2_uc003xpe.2_Intron	NM_006749	NP_006740			solute carrier family 20, member 2						interspecies interaction between organisms	integral to plasma membrane|membrane fraction	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			ovary(2)	2	all_lung(13;8.33e-12)|Lung NSC(13;1.41e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;5.73e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00419)|Lung(22;0.0302)|LUSC - Lung squamous cell carcinoma(45;0.0869)															---	---	---	---
Unknown	0	broad.mit.edu	37	8	42538760	42538760	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:42538760delA								C8orf40 (130621 upstream) : CHRNB3 (13802 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	8	48144963	48144963	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:48144963delA								BEYLA (377556 upstream) : KIAA0146 (28579 downstream)																																			---	---	---	---
PRKDC	5591	broad.mit.edu	37	8	48701621	48701621	+	Intron	DEL	A	-	-	rs34211555		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:48701621delA	uc003xqi.2	-						PRKDC_uc003xqj.2_Intron|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835			protein kinase, DNA-activated, catalytic						cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)											NHEJ					---	---	---	---
EFCAB1	79645	broad.mit.edu	37	8	49643852	49643852	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:49643852delT	uc003xqo.2	-						EFCAB1_uc003xqn.3_Intron|EFCAB1_uc011ldj.1_Intron|EFCAB1_uc010lxx.2_Intron|EFCAB1_uc011ldk.1_Intron	NM_024593	NP_078869			EF-hand calcium binding domain 1 isoform a								calcium ion binding				0		all_epithelial(80;0.0134)|Lung NSC(129;0.0207)|all_lung(136;0.0464)																---	---	---	---
TGS1	96764	broad.mit.edu	37	8	56705105	56705105	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:56705105delT	uc003xsj.3	+						TGS1_uc010lyh.2_Intron	NM_024831	NP_079107			trimethylguanosine synthase homolog						cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			ovary(1)|lung(1)|breast(1)	3		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)															---	---	---	---
NSMAF	8439	broad.mit.edu	37	8	59499343	59499343	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:59499343delA	uc003xtt.2	-						NSMAF_uc011lee.1_Intron	NM_003580	NP_003571			neutral sphingomyelinase (N-SMase) activation						ceramide metabolic process	cytoplasm|soluble fraction	protein binding|receptor signaling protein activity			ovary(1)	1		all_lung(136;0.174)|Lung NSC(129;0.2)																---	---	---	---
CA8	767	broad.mit.edu	37	8	61139553	61139553	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:61139553delA	uc003xtz.1	-						CA8_uc003xua.1_Intron	NM_004056	NP_004047			carbonic anhydrase VIII						one-carbon metabolic process		carbonate dehydratase activity|zinc ion binding				0		all_cancers(86;0.172)|all_epithelial(80;0.0383)|all_lung(136;0.0413)|Lung NSC(129;0.0474)																---	---	---	---
CHD7	55636	broad.mit.edu	37	8	61778454	61778454	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:61778454delG	uc003xue.2	+	38	9433	c.8956delG	c.(8956-8958)GGGfs	p.G2986fs		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2986					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)															---	---	---	---
CYP7B1	9420	broad.mit.edu	37	8	65528077	65528078	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:65528077_65528078delAA	uc003xvj.2	-							NM_004820	NP_004811			cytochrome P450, family 7, subfamily B,						bile acid biosynthetic process|cell death|cholesterol metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	25-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity			ovary(3)	3		all_cancers(86;0.217)|Lung NSC(129;0.0521)|all_lung(136;0.0906)|all_epithelial(80;0.215)																---	---	---	---
PDE7A	5150	broad.mit.edu	37	8	66636440	66636440	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:66636440delA	uc003xvq.2	-						PDE7A_uc003xvr.2_Intron|PDE7A_uc003xvp.2_Intron	NM_002604	NP_002595			phosphodiesterase 7A isoform b							cell fraction|cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding				0			Epithelial(68;0.0509)|BRCA - Breast invasive adenocarcinoma(89;0.111)|all cancers(69;0.168)|OV - Ovarian serous cystadenocarcinoma(28;0.238)		Dyphylline(DB00651)|Ketotifen(DB00920)													---	---	---	---
RRS1	23212	broad.mit.edu	37	8	67341501	67341501	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:67341501delC	uc003xwa.2	+	1	239	c.135delC	c.(133-135)AACfs	p.N45fs		NM_015169	NP_055984	Q15050	RRS1_HUMAN	homolog of yeast ribosome biogenesis regulatory	45					mitotic metaphase plate congression|ribosome biogenesis	condensed nuclear chromosome|nucleolus					0		Lung NSC(129;0.197)	Epithelial(68;0.0391)|all cancers(69;0.0898)|BRCA - Breast invasive adenocarcinoma(89;0.111)|OV - Ovarian serous cystadenocarcinoma(28;0.226)													OREG0018806	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
ADHFE1	137872	broad.mit.edu	37	8	67357336	67357336	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:67357336delA	uc003xwb.3	+						ADHFE1_uc003xwd.3_Intron|ADHFE1_uc003xwc.3_Intron|ADHFE1_uc003xwe.3_Intron|ADHFE1_uc003xwf.3_Intron|ADHFE1_uc011les.1_Intron|ADHFE1_uc011leq.1_Intron|ADHFE1_uc011ler.1_Intron	NM_144650	NP_653251			alcohol dehydrogenase, iron containing, 1						2-oxoglutarate metabolic process|molecular hydrogen transport	mitochondrial matrix	hydroxyacid-oxoacid transhydrogenase activity|metal ion binding			ovary(1)|lung(1)|breast(1)|skin(1)	4		Lung NSC(129;0.197)	Epithelial(68;0.0321)|all cancers(69;0.0751)|BRCA - Breast invasive adenocarcinoma(89;0.0855)|OV - Ovarian serous cystadenocarcinoma(28;0.226)															---	---	---	---
LRRC67	286187	broad.mit.edu	37	8	67925535	67925535	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:67925535delT	uc003xxc.2	-							NM_001013626	NP_001013648			leucine rich repeat containing 67												0																		---	---	---	---
ARFGEF1	10565	broad.mit.edu	37	8	68208890	68208890	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:68208890delT	uc003xxo.1	-							NM_006421	NP_006412			brefeldin A-inhibited guanine						exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)															---	---	---	---
ARFGEF1	10565	broad.mit.edu	37	8	68214710	68214710	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:68214710delA	uc003xxo.1	-							NM_006421	NP_006412			brefeldin A-inhibited guanine						exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)															---	---	---	---
C8orf34	116328	broad.mit.edu	37	8	69699867	69699867	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:69699867delA	uc010lyz.2	+						C8orf34_uc003xyb.2_Intron	NM_052958	NP_443190			hypothetical protein LOC116328						signal transduction		cAMP-dependent protein kinase regulator activity			large_intestine(1)	1			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)															---	---	---	---
HNF4G	3174	broad.mit.edu	37	8	76465212	76465212	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:76465212delA	uc003yaq.2	+						HNF4G_uc003yar.2_Intron	NM_004133	NP_004124			hepatocyte nuclear factor 4, gamma						endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)															---	---	---	---
Unknown	0	broad.mit.edu	37	8	76722793	76722796	+	IGR	DEL	TTCC	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:76722793_76722796delTTCC								HNF4G (243734 upstream) : LOC100192378 (800319 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	8	82530375	82530376	+	IGR	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:82530375_82530376delTT								FABP12 (86825 upstream) : IMPA1 (38775 downstream)																																			---	---	---	---
LRRCC1	85444	broad.mit.edu	37	8	86027524	86027524	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:86027524delT	uc003ycw.2	+						LRRCC1_uc010lzz.1_Intron|LRRCC1_uc010maa.1_Intron|LRRCC1_uc003ycx.2_Intron|LRRCC1_uc003ycy.2_Intron	NM_033402	NP_208325			sodium channel associated protein 2 isoform a						cell division|mitosis	centriole|nucleus					0																		---	---	---	---
TMEM64	169200	broad.mit.edu	37	8	91637754	91637755	+	3'UTR	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:91637754_91637755delAA	uc003yen.2	-	3					TMEM64_uc003yeo.2_3'UTR|TMEM64_uc011lgf.1_3'UTR	NM_001008495	NP_001008495			transmembrane protein 64 isoform 1							integral to membrane					0			BRCA - Breast invasive adenocarcinoma(11;0.0598)															---	---	---	---
OTUD6B	51633	broad.mit.edu	37	8	92096993	92096993	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:92096993delT	uc003yeu.3	+						OTUD6B_uc011lgh.1_Intron	NM_016023	NP_057107			OTU domain containing 6B											ovary(2)|lung(1)	3			BRCA - Breast invasive adenocarcinoma(11;0.0187)															---	---	---	---
FAM92A1	137392	broad.mit.edu	37	8	94738534	94738534	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:94738534delA	uc010maq.2	+						FAM92A1_uc003yfv.3_Intron|FAM92A1_uc003yfx.3_Intron|FAM92A1_uc003yfw.3_Intron|FAM92A1_uc010mar.2_Intron	NM_145269	NP_660312			hypothetical protein LOC137392												0	Breast(36;2.4e-06)		BRCA - Breast invasive adenocarcinoma(8;0.0168)															---	---	---	---
RBM12B	389677	broad.mit.edu	37	8	94745548	94745548	+	3'UTR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:94745548delA	uc003yfz.2	-	3						NM_203390	NP_976324			RNA binding motif protein 12B								nucleotide binding|RNA binding				0	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)															---	---	---	---
ESRP1	54845	broad.mit.edu	37	8	95686611	95686611	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:95686611delA	uc003ygq.3	+	12	1711	c.1528delA	c.(1528-1530)AAAfs	p.K510fs	ESRP1_uc003ygr.3_Frame_Shift_Del_p.K510fs|ESRP1_uc003ygs.3_Frame_Shift_Del_p.K510fs|ESRP1_uc003ygt.3_Frame_Shift_Del_p.K510fs|ESRP1_uc003ygu.3_Frame_Shift_Del_p.K510fs|ESRP1_uc003ygv.2_Frame_Shift_Del_p.K350fs|ESRP1_uc003ygw.2_Frame_Shift_Del_p.K350fs	NM_017697	NP_060167	Q6NXG1	ESRP1_HUMAN	RNA binding motif protein 35A isoform 1	510	RRM 3.				mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	prostate(4)	4																		---	---	---	---
LAPTM4B	55353	broad.mit.edu	37	8	98827797	98827797	+	Intron	DEL	T	-	-	rs111936259		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:98827797delT	uc003yia.2	+						LAPTM4B_uc010mbg.2_Intron	NM_018407	NP_060877			lysosomal associated transmembrane protein 4						transport	endomembrane system|integral to membrane	protein binding			skin(1)	1	Breast(36;1.59e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.149)															---	---	---	---
RPL30	6156	broad.mit.edu	37	8	99054504	99054504	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:99054504delT	uc003yif.2	-						RPL30_uc010mbk.1_Intron|SNORA72_uc003yig.1_5'Flank	NM_000989	NP_000980			ribosomal protein L30						endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	RNA binding|structural constituent of ribosome				0	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.192)															---	---	---	---
POP1	10940	broad.mit.edu	37	8	99148630	99148630	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:99148630delA	uc003yij.3	+						POP1_uc011lgv.1_Intron|POP1_uc003yik.2_Intron	NM_001145860	NP_001139332			processing of precursor 1						tRNA 5'-leader removal|tRNA catabolic process	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease MRP activity|ribonuclease P activity			ovary(1)|breast(1)	2	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.145)															---	---	---	---
NIPAL2	79815	broad.mit.edu	37	8	99264978	99264978	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:99264978delT	uc003yil.1	-						NIPAL2_uc011lgw.1_5'Flank|NIPAL2_uc003yim.1_Intron	NM_024759	NP_079035			NIPA-like domain containing 2							integral to membrane					0																		---	---	---	---
YWHAZ	7534	broad.mit.edu	37	8	101936665	101936665	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:101936665delT	uc011lhe.1	-						YWHAZ_uc003yjv.2_Intron|YWHAZ_uc011lhf.1_Intron|YWHAZ_uc003yjw.2_Intron|YWHAZ_uc010mbq.2_Intron|YWHAZ_uc011lhg.1_Intron|YWHAZ_uc010mbr.2_Intron|YWHAZ_uc003yjx.2_Intron|YWHAZ_uc003yjy.2_Intron	NM_001135702	NP_001129174			tyrosine 3/tryptophan 5 -monooxygenase						anti-apoptosis|mRNA metabolic process|platelet activation|signal transduction	cytosol|melanosome	transcription factor binding				0	all_cancers(14;7.43e-06)|all_epithelial(15;2.77e-08)|Lung NSC(17;6.08e-05)|all_lung(17;0.000197)		Epithelial(11;2.79e-11)|all cancers(13;5.45e-09)|OV - Ovarian serous cystadenocarcinoma(57;4.75e-05)		Ginkgo biloba(DB01381)													---	---	---	---
Unknown	0	broad.mit.edu	37	8	103487951	103487951	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:103487951delT								UBR5 (63456 upstream) : ODF1 (75897 downstream)																																			---	---	---	---
NUDCD1	84955	broad.mit.edu	37	8	110257725	110257725	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:110257725delA	uc003ynb.3	-						NUDCD1_uc003yna.2_Intron|NUDCD1_uc010mcl.2_Intron	NM_032869	NP_116258			NudC domain containing 1 isoform 1											ovary(1)|breast(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;1.56e-12)															---	---	---	---
PKHD1L1	93035	broad.mit.edu	37	8	110413824	110413824	+	Intron	DEL	C	-	-	rs2061294	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:110413824delC	uc003yne.2	+							NM_177531	NP_803875			fibrocystin L precursor						immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)												HNSCC(38;0.096)			---	---	---	---
PKHD1L1	93035	broad.mit.edu	37	8	110460747	110460748	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:110460747_110460748delTT	uc003yne.2	+							NM_177531	NP_803875			fibrocystin L precursor						immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)												HNSCC(38;0.096)			---	---	---	---
PKHD1L1	93035	broad.mit.edu	37	8	110464253	110464254	+	Intron	INS	-	T	T	rs149400770	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:110464253_110464254insT	uc003yne.2	+							NM_177531	NP_803875			fibrocystin L precursor						immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)												HNSCC(38;0.096)			---	---	---	---
EIF3H	8667	broad.mit.edu	37	8	117668365	117668366	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:117668365_117668366delAA	uc003yoa.2	-						EIF3H_uc003yob.2_Intron	NM_003756	NP_003747			eukaryotic translation initiation factor 3,						regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			lung(3)	3	all_cancers(13;3.98e-22)|Lung NSC(37;0.000183)|Ovarian(258;0.0172)																	---	---	---	---
EXT1	2131	broad.mit.edu	37	8	119108904	119108919	+	Intron	DEL	AGGAAGGAAGGGAGGG	-	-	rs72254367		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:119108904_119108919delAGGAAGGAAGGGAGGG	uc003yok.1	-							NM_000127	NP_000118			exostosin 1						glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction|skeletal system development	Golgi membrane|integral to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|lung(2)	4	all_cancers(13;2.36e-26)|Lung NSC(37;5.02e-07)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.012)					Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses|Langer-Giedion_syndrome				---	---	---	---
TAF2	6873	broad.mit.edu	37	8	120770136	120770136	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:120770136delA	uc003you.2	-							NM_003184	NP_003175			TBP-associated factor 2						G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(2)|ovary(2)|kidney(1)|skin(1)	6	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)															---	---	---	---
WDR67	93594	broad.mit.edu	37	8	124138174	124138174	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:124138174delT	uc003ypp.1	+						WDR67_uc011lig.1_Intron|WDR67_uc011lih.1_Intron|WDR67_uc003ypq.1_Intron|WDR67_uc003yps.1_Intron|WDR67_uc003ypt.1_5'Flank|WDR67_uc003ypu.1_5'Flank	NM_145647	NP_663622			WD repeat domain 67 isoform 1							centrosome	Rab GTPase activator activity			skin(1)	1	Lung NSC(37;7e-10)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)															---	---	---	---
FER1L6	654463	broad.mit.edu	37	8	124968212	124968212	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:124968212delT	uc003yqw.2	+							NM_001039112	NP_001034201			fer-1-like 6							integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)															---	---	---	---
TATDN1	83940	broad.mit.edu	37	8	125520941	125520942	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:125520941_125520942delAA	uc003yrd.2	-						TATDN1_uc003yre.2_Intron|TATDN1_uc010mdm.2_Intron|TATDN1_uc003yrf.2_Intron	NM_032026	NP_114415			TatD DNase domain containing 1 isoform a							nucleus	endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding				0	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)															---	---	---	---
Unknown	0	broad.mit.edu	37	8	125850042	125850043	+	IGR	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:125850042_125850043insT								MTSS1 (109312 upstream) : LOC157381 (101841 downstream)																																			---	---	---	---
FAM49B	51571	broad.mit.edu	37	8	130874724	130874724	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:130874724delT	uc003yss.2	-						FAM49B_uc003yst.2_Intron|FAM49B_uc003ysu.2_Intron|FAM49B_uc003ysv.2_Intron|FAM49B_uc003ysw.2_Intron|FAM49B_uc003ysx.2_Intron|FAM49B_uc003ysy.1_Intron	NM_016623	NP_057707			hypothetical protein LOC51571												0	Ovarian(5;0.000567)|Esophageal squamous(12;0.00693)|Acute lymphoblastic leukemia(118;0.155)		LUAD - Lung adenocarcinoma(14;0.0989)															---	---	---	---
COL22A1	169044	broad.mit.edu	37	8	139793232	139793232	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:139793232delA	uc003yvd.2	-							NM_152888	NP_690848			collagen, type XXII, alpha 1						cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)												HNSCC(7;0.00092)			---	---	---	---
Unknown	0	broad.mit.edu	37	8	142343687	142343687	+	IGR	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:142343687delG								SLC45A4 (79462 upstream) : LOC731779 (6961 downstream)																																			---	---	---	---
TSNARE1	203062	broad.mit.edu	37	8	143356289	143356289	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:143356289delC	uc003ywk.2	-						TSNARE1_uc011lju.1_Intron|TSNARE1_uc003ywj.2_Intron|TSNARE1_uc003ywl.3_Intron	NM_145003	NP_659440			t-SNARE domain containing 1						vesicle-mediated transport	integral to membrane					0	all_cancers(97;7.39e-11)|all_epithelial(106;8.98e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000332)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)																	---	---	---	---
EEF1D	1936	broad.mit.edu	37	8	144668488	144668488	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:144668488delT	uc011lki.1	-						EEF1D_uc003yyp.1_Intron|EEF1D_uc003yyq.1_Intron|EEF1D_uc011lkj.1_Intron|EEF1D_uc003yyr.2_Intron|EEF1D_uc003yyt.2_Intron|EEF1D_uc011lkk.1_Intron|EEF1D_uc003yys.2_Intron|EEF1D_uc003yyv.2_Intron|EEF1D_uc003yyu.2_Intron|EEF1D_uc011lkl.1_Intron	NM_001130057	NP_001123529			eukaryotic translation elongation factor 1 delta						positive regulation of I-kappaB kinase/NF-kappaB cascade	cytosol|eukaryotic translation elongation factor 1 complex	protein binding|signal transducer activity|translation elongation factor activity			ovary(1)|kidney(1)|skin(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)															---	---	---	---
SMARCA2	6595	broad.mit.edu	37	9	2161562	2161562	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:2161562delT	uc003zhc.2	+						SMARCA2_uc003zhd.2_Intron|SMARCA2_uc010mha.2_Intron|SMARCA2_uc011llw.1_Intron|SMARCA2_uc003zhf.2_Intron|SMARCA2_uc011llx.1_Intron|SMARCA2_uc003zhe.2_Intron|SMARCA2_uc003zhg.2_Intron|SMARCA2_uc010mhb.2_Intron	NM_003070	NP_003061			SWI/SNF-related matrix-associated						chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)														---	---	---	---
GLIS3	169792	broad.mit.edu	37	9	4126054	4126055	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:4126054_4126055delTT	uc003zhw.1	-						GLIS3_uc003zhx.1_Intron|GLIS3_uc003zic.1_Intron|GLIS3_uc003zie.1_Intron|GLIS3_uc010mhh.1_Intron|GLIS3_uc003zid.1_Intron|GLIS3_uc010mhi.1_Intron|GLIS3_uc003zif.1_Intron|GLIS3_uc003zig.1_Intron|GLIS3_uc003zih.1_Intron|GLIS3_uc003zib.1_Intron|GLIS3_uc010mhg.1_Intron	NM_152629	NP_689842			GLIS family zinc finger 3 isoform b						negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)														---	---	---	---
SLC1A1	6505	broad.mit.edu	37	9	4561291	4561292	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:4561291_4561292insT	uc003zij.1	+						C9orf68_uc003zik.2_Intron	NM_004170	NP_004161			solute carrier family 1, member 1						D-aspartate import|L-glutamate import|synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity				0		Acute lymphoblastic leukemia(2;0.0359)|Breast(48;0.0457)		GBM - Glioblastoma multiforme(50;0.0124)|Lung(218;0.183)	L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)													---	---	---	---
Unknown	0	broad.mit.edu	37	9	4781395	4781401	+	IGR	DEL	TTTTTTT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:4781395_4781401delTTTTTTT								AK3 (39352 upstream) : RCL1 (11433 downstream)																																			---	---	---	---
RCL1	10171	broad.mit.edu	37	9	4860070	4860071	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:4860070_4860071insT	uc003zis.2	+						RCL1_uc003zit.2_Intron|RCL1_uc010mhk.1_Intron|RCL1_uc010mhl.1_Intron|RCL1_uc003ziv.1_5'Flank	NM_005772	NP_005763			RNA terminal phosphate cyclase-like 1						ribosome biogenesis|RNA processing	nucleolus	RNA-3'-phosphate cyclase activity				0	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0206)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0244)														---	---	---	---
C9orf46	55848	broad.mit.edu	37	9	5361173	5361173	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:5361173delT	uc003zjc.2	-	5	431	c.227delA	c.(226-228)AAGfs	p.K76fs	C9orf46_uc003zjd.2_Frame_Shift_Del_p.K76fs	NM_018465	NP_060935	Q9HBL7	CI046_HUMAN	hypothetical protein LOC55848	76						integral to membrane				ovary(1)	1	all_hematologic(13;0.158)	Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.00106)|Lung(218;0.125)														---	---	---	---
UHRF2	115426	broad.mit.edu	37	9	6475180	6475180	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:6475180delT	uc003zjy.2	+						UHRF2_uc003zjz.2_Intron|UHRF2_uc003zka.1_Intron	NM_152896	NP_690856			ubiquitin-like with PHD and ring finger domains						cell cycle|cell differentiation|cell proliferation|protein autoubiquitination|regulation of cell cycle|ubiquitin-dependent protein catabolic process	nucleus	DNA binding|histone binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0392)|Lung(218;0.129)														---	---	---	---
C9orf123	90871	broad.mit.edu	37	9	7798642	7798642	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:7798642delA	uc003zki.2	-						C9orf123_uc003zkj.2_Intron					Homo sapiens cDNA FLJ46908 fis, clone FEBRA2004867.							integral to membrane					0		all_cancers(3;0.0539)|Lung NSC(3;3.36e-05)|all_lung(3;0.000156)|all_epithelial(3;0.0356)		GBM - Glioblastoma multiforme(50;0.0561)														---	---	---	---
PTPRD	5789	broad.mit.edu	37	9	8501114	8501114	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:8501114delA	uc003zkk.2	-						PTPRD_uc003zkp.2_Intron|PTPRD_uc003zkq.2_Intron|PTPRD_uc003zkr.2_Intron|PTPRD_uc003zks.2_Intron|PTPRD_uc003zkl.2_Intron|PTPRD_uc003zkm.2_Intron|PTPRD_uc003zkn.2_Intron|PTPRD_uc003zko.2_Intron	NM_002839	NP_002830			protein tyrosine phosphatase, receptor type, D						transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)											TSP Lung(15;0.13)			---	---	---	---
Unknown	0	broad.mit.edu	37	9	12530917	12530918	+	IGR	DEL	AG	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:12530917_12530918delAG								None (None upstream) : TYRP1 (162468 downstream)																																			---	---	---	---
MPDZ	8777	broad.mit.edu	37	9	13125277	13125277	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:13125277delT	uc010mia.1	-	34	4802	c.4745delA	c.(4744-4746)AAGfs	p.K1582fs	MPDZ_uc003zky.3_Frame_Shift_Del_p.K144fs|MPDZ_uc010mib.2_Frame_Shift_Del_p.K287fs|MPDZ_uc010mhx.2_Frame_Shift_Del_p.K404fs|MPDZ_uc011lmm.1_Frame_Shift_Del_p.K441fs|MPDZ_uc003zkz.3_Frame_Shift_Del_p.K275fs|MPDZ_uc010mhy.2_Frame_Shift_Del_p.K1582fs|MPDZ_uc010mhz.2_Frame_Shift_Del_p.K1549fs|MPDZ_uc011lmn.1_Frame_Shift_Del_p.K1549fs|MPDZ_uc003zlb.3_Frame_Shift_Del_p.K1582fs	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1582					interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)														---	---	---	---
FREM1	158326	broad.mit.edu	37	9	14759696	14759696	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:14759696delA	uc003zlm.2	-						FREM1_uc010mic.2_Intron|FREM1_uc003zlk.2_Intron|FREM1_uc003zll.2_Intron	NM_144966	NP_659403			FRAS1 related extracellular matrix 1 precursor						cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)														---	---	---	---
HAUS6	54801	broad.mit.edu	37	9	19082750	19082750	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:19082750delA	uc003znk.2	-						HAUS6_uc011lmz.1_Intron|HAUS6_uc003znl.1_Intron|HAUS6_uc003znm.1_Intron	NM_017645	NP_060115			HAUS augmin-like complex, subunit 6						cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|nucleus|spindle				ovary(2)	2																		---	---	---	---
DENND4C	55667	broad.mit.edu	37	9	19360231	19360231	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:19360231delT	uc003znq.2	+						DENND4C_uc011lnc.1_Intron|DENND4C_uc011lnd.1_Intron|DENND4C_uc003znr.2_Intron|DENND4C_uc003zns.2_Intron	NM_017925	NP_060395			DENN/MADD domain containing 4C							integral to membrane				ovary(1)|skin(1)	2																		---	---	---	---
DENND4C	55667	broad.mit.edu	37	9	19370037	19370037	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:19370037delA	uc003znq.2	+						DENND4C_uc011lnc.1_Intron|DENND4C_uc011lnd.1_Intron|DENND4C_uc003znr.2_3'UTR|DENND4C_uc003zns.2_Intron	NM_017925	NP_060395			DENN/MADD domain containing 4C							integral to membrane				ovary(1)|skin(1)	2																		---	---	---	---
ACER2	340485	broad.mit.edu	37	9	19434763	19434763	+	Intron	DEL	T	-	-	rs144391104		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:19434763delT	uc003zny.1	+						ACER2_uc003znx.1_Intron|ACER2_uc003znz.1_Intron	NM_001010887	NP_001010887			alkaline ceramidase 2						ceramide metabolic process|negative regulation of cell adhesion mediated by integrin|negative regulation of cell-matrix adhesion|negative regulation of protein glycosylation in Golgi|positive regulation of cell proliferation|response to retinoic acid|sphingosine biosynthetic process	integral to Golgi membrane	ceramidase activity			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2																		---	---	---	---
KIAA1797	54914	broad.mit.edu	37	9	20993167	20993168	+	Intron	INS	-	AT	AT			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:20993167_20993168insAT	uc003zog.1	+						KIAA1797_uc003zoh.1_Intron	NM_017794	NP_060264			hypothetical protein LOC54914							integral to membrane	binding			ovary(8)|breast(1)|kidney(1)	10				GBM - Glioblastoma multiforme(3;2.1e-125)|Lung(42;2.76e-14)|LUSC - Lung squamous cell carcinoma(42;1.99e-11)														---	---	---	---
PLAA	9373	broad.mit.edu	37	9	26923082	26923082	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:26923082delA	uc003zqd.2	-						PLAA_uc003zqe.2_Intron	NM_001031689	NP_001026859			phospholipase A2-activating protein						phospholipid metabolic process|signal transduction		phospholipase A2 activator activity				0		all_neural(3;3.53e-10)|Glioma(3;2.71e-09)		Lung(218;1.32e-05)|LUSC - Lung squamous cell carcinoma(38;0.00011)														---	---	---	---
IFT74	80173	broad.mit.edu	37	9	27060506	27060506	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:27060506delT	uc010mja.2	+						IFT74_uc010mjb.2_Intron|IFT74_uc003zqg.3_Intron	NM_001099223	NP_001092693			coiled-coil domain containing 2 isoform a							cytoplasmic membrane-bounded vesicle|intraflagellar transport particle B|microtubule-based flagellum				skin(1)	1		all_neural(11;2.36e-10)		Lung(218;1.4e-05)|LUSC - Lung squamous cell carcinoma(38;0.000114)														---	---	---	---
Unknown	0	broad.mit.edu	37	9	29826281	29826281	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:29826281delT								MIR873 (937328 upstream) : None (None downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	9	29999679	29999679	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:29999679delA								None (None upstream) : None (None downstream)																																			---	---	---	---
DDX58	23586	broad.mit.edu	37	9	32472893	32472894	+	Intron	DEL	AC	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:32472893_32472894delAC	uc003zra.2	-						DDX58_uc010mjj.2_Intron|DDX58_uc010mjk.1_Intron|DDX58_uc011lnr.1_Intron|DDX58_uc010mji.2_Intron	NM_014314	NP_055129			DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide						detection of virus|innate immune response|negative regulation of type I interferon production|positive regulation of defense response to virus by host|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	cytosol	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|protein binding|zinc ion binding			ovary(2)|liver(1)|pancreas(1)	4			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;0.00056)														---	---	---	---
PTENP1	11191	broad.mit.edu	37	9	33675365	33675365	+	3'UTR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:33675365delA	uc003zth.3	-	1						NR_023917				SubName: Full=Phosphatase and tensin homolog 2; Flags: Fragment;												0																		---	---	---	---
Unknown	0	broad.mit.edu	37	9	34923047	34923047	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:34923047delT								C9orf144 (84464 upstream) : KIAA1045 (34474 downstream)																																			---	---	---	---
RNF38	152006	broad.mit.edu	37	9	36353341	36353341	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:36353341delA	uc003zzh.2	-						RNF38_uc003zzi.2_Intron|RNF38_uc003zzj.2_Intron|RNF38_uc003zzk.2_Intron|RNF38_uc003zzl.2_Intron|RNF38_uc003zzm.2_Intron	NM_022781	NP_073618			ring finger protein 38 isoform 1								zinc ion binding			central_nervous_system(1)	1			STAD - Stomach adenocarcinoma(86;0.228)															---	---	---	---
ZNF658	26149	broad.mit.edu	37	9	40771888	40771888	+	3'UTR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:40771888delT	uc004abs.2	-	5					ZNF658_uc010mmm.1_Intron|ZNF658_uc010mmn.1_3'UTR	NM_033160	NP_149350			zinc finger protein 658						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)														---	---	---	---
FAM122A	116224	broad.mit.edu	37	9	71395787	71395788	+	Frame_Shift_Del	DEL	GT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:71395787_71395788delGT	uc004agw.1	+	1	824_825	c.707_708delGT	c.(706-708)GGTfs	p.G236fs	PIP5K1B_uc004agu.2_Intron|PIP5K1B_uc011lrq.1_Intron|PIP5K1B_uc004agv.2_Intron	NM_138333	NP_612206	Q96E09	F122A_HUMAN	hypothetical protein LOC116224	236											0																		---	---	---	---
PIP5K1B	8395	broad.mit.edu	37	9	71555419	71555419	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:71555419delA	uc004agu.2	+						PIP5K1B_uc011lrq.1_Intron|PIP5K1B_uc004agv.2_Intron	NM_003558	NP_003549			phosphatidylinositol-4-phosphate 5-kinase, type							endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			stomach(1)	1				Lung(182;0.133)														---	---	---	---
TJP2	9414	broad.mit.edu	37	9	71852905	71852905	+	Intron	DEL	T	-	-	rs73450890	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:71852905delT	uc004ahe.2	+						TJP2_uc011lrs.1_Intron|TJP2_uc011lrt.1_Intron|TJP2_uc004ahd.2_Intron|TJP2_uc004ahf.2_Intron|TJP2_uc011lru.1_Intron|TJP2_uc011lrv.1_Intron	NM_004817	NP_004808			tight junction protein 2 (zona occludens 2)						cellular component disassembly involved in apoptosis	adherens junction|cytoplasm|nucleus|tight junction	guanylate kinase activity|protein binding				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	9	72842857	72842857	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:72842857delT	uc004ahq.1	-											Homo sapiens cDNA FLJ42142 fis, clone TESTI2045155.																														---	---	---	---
TMC1	117531	broad.mit.edu	37	9	75430881	75430881	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:75430881delA	uc004aiz.1	+						TMC1_uc010moz.1_Intron|TMC1_uc004aja.1_Intron|TMC1_uc004ajb.1_Intron|TMC1_uc004ajc.1_Intron|TMC1_uc010mpa.1_Intron	NM_138691	NP_619636			transmembrane channel-like 1						sensory perception of sound	integral to membrane				ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	9	76091073	76091073	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:76091073delT								ANXA1 (305766 upstream) : None (None downstream)																																			---	---	---	---
TRPM6	140803	broad.mit.edu	37	9	77407756	77407756	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:77407756delA	uc004ajl.1	-						TRPM6_uc004ajk.1_Intron|TRPM6_uc010mpb.1_Intron|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajm.1_Intron	NM_017662	NP_060132			transient receptor potential cation channel,						response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8																		---	---	---	---
PCSK5	5125	broad.mit.edu	37	9	78799576	78799576	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:78799576delT	uc004ajz.2	+						PCSK5_uc004aka.2_Intron|PCSK5_uc004akb.2_Intron	NM_006200	NP_006191			proprotein convertase subtilisin/kexin type 5						anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3																		---	---	---	---
VPS13A	23230	broad.mit.edu	37	9	79897181	79897181	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:79897181delA	uc004akr.2	+	29	3369	c.3109delA	c.(3109-3111)AAAfs	p.K1037fs	VPS13A_uc004akp.3_Frame_Shift_Del_p.K1037fs|VPS13A_uc004akq.3_Frame_Shift_Del_p.K1037fs|VPS13A_uc004aks.2_Frame_Shift_Del_p.K1037fs	NM_033305	NP_150648	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13A isoform A	1037					Golgi to endosome transport|protein transport	intracellular	protein binding			pancreas(3)|skin(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	10																		---	---	---	---
KIF27	55582	broad.mit.edu	37	9	86457388	86457388	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:86457388delT	uc004ana.2	-						KIF27_uc010mpw.2_Intron|KIF27_uc010mpx.2_Intron	NM_017576	NP_060046			kinesin family member 27						cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			lung(4)|skin(1)	5																		---	---	---	---
KIF27	55582	broad.mit.edu	37	9	86503510	86503511	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:86503510_86503511insA	uc004ana.2	-						KIF27_uc010mpw.2_Intron|KIF27_uc010mpx.2_Intron	NM_017576	NP_060046			kinesin family member 27						cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			lung(4)|skin(1)	5																		---	---	---	---
HNRNPK	3190	broad.mit.edu	37	9	86584096	86584096	+	3'UTR	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:86584096delC	uc004ang.3	-	17					HNRNPK_uc011lsw.1_3'UTR|HNRNPK_uc004and.3_3'UTR|HNRNPK_uc004ank.3_3'UTR|HNRNPK_uc004anf.3_3'UTR|HNRNPK_uc004anh.3_3'UTR|HNRNPK_uc011lsx.1_3'UTR|HNRNPK_uc004ani.3_3'UTR|HNRNPK_uc004anj.3_3'UTR|HNRNPK_uc004ann.3_3'UTR|HNRNPK_uc004anl.3_3'UTR|HNRNPK_uc004anm.3_3'UTR	NM_031262	NP_112552			heterogeneous nuclear ribonucleoprotein K						interspecies interaction between organisms|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of receptor-mediated endocytosis|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of low-density lipoprotein particle clearance|signal transduction	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nuclear chromatin|nucleoplasm	protein binding|RNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|single-stranded DNA binding			skin(1)	1																		---	---	---	---
NTRK2	4915	broad.mit.edu	37	9	87636093	87636093	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:87636093delT	uc004aoa.1	+						NTRK2_uc004anz.1_Intron	NM_001018064	NP_001018074			neurotrophic tyrosine kinase, receptor, type 2						activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			lung(11)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|liver(1)	16															TSP Lung(25;0.17)			---	---	---	---
Unknown	0	broad.mit.edu	37	9	88551425	88551425	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:88551425delT								AGTPBP1 (194481 upstream) : NAA35 (4632 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	9	88990441	88990442	+	IGR	INS	-	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:88990441_88990442insG								ZCCHC6 (21063 upstream) : GAS1 (568837 downstream)																																			---	---	---	---
SPIN1	10927	broad.mit.edu	37	9	91026437	91026437	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:91026437delT	uc010mqj.2	+						SPIN1_uc004apy.2_Intron|SPIN1_uc004apz.2_Intron|SPIN1_uc010mqk.2_Intron	NM_006717	NP_006708			spindlin						cell cycle|gamete generation|multicellular organismal development	nucleus	methylated histone residue binding				0																		---	---	---	---
SECISBP2	79048	broad.mit.edu	37	9	91934385	91934385	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:91934385delA	uc004aqj.1	+						SECISBP2_uc010mqn.1_Intron|SECISBP2_uc004aqi.1_Intron|SECISBP2_uc011ltk.1_Intron|SECISBP2_uc004aqk.1_Intron|SECISBP2_uc010mqo.1_Intron|SECISBP2_uc011ltl.1_Intron	NM_024077	NP_076982			SECIS binding protein 2						translation	nucleus	mRNA 3'-UTR binding			ovary(2)|skin(1)	3																		---	---	---	---
SEMA4D	10507	broad.mit.edu	37	9	92011547	92011548	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:92011547_92011548insT	uc004aqo.1	-						SEMA4D_uc011ltm.1_Intron|SEMA4D_uc011ltn.1_Intron|SEMA4D_uc011lto.1_Intron|SEMA4D_uc004aqp.1_Intron	NM_006378	NP_006369			semaphorin 4D isoform 1						anti-apoptosis|axon guidance|cell adhesion|immune response	integral to membrane|plasma membrane	receptor activity|receptor binding			ovary(1)|pancreas(1)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	9	93932373	93932373	+	IGR	DEL	A	-	-	rs78734638		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:93932373delA								SYK (271540 upstream) : AUH (43726 downstream)																																			---	---	---	---
NOL8	55035	broad.mit.edu	37	9	95085870	95085871	+	Intron	DEL	AA	-	-	rs75489638		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:95085870_95085871delAA	uc004arv.2	-						CENPP_uc004arz.2_5'Flank|CENPP_uc010mqx.2_5'Flank|NOL8_uc004arw.2_Intron|NOL8_uc011ltw.1_Intron|NOL8_uc004arx.2_Intron|CENPP_uc004ary.1_5'Flank	NM_017948	NP_060418			nucleolar protein 8						DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			ovary(1)	1																		---	---	---	---
PHF2	5253	broad.mit.edu	37	9	96422612	96422612	+	Frame_Shift_Del	DEL	A	-	-	rs76832193		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:96422612delA	uc004aub.2	+	12	1615	c.1468delA	c.(1468-1470)AAAfs	p.K490fs	PHF2_uc011lug.1_Frame_Shift_Del_p.K373fs|PHF2_uc004auc.2_5'Flank	NM_005392	NP_005383	O75151	PHF2_HUMAN	PHD finger protein 2	490	Pro-rich.|Lys-rich.				liver development|negative regulation of chromatin silencing at rDNA|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K9 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;9.11e-28)														---	---	---	---
CDC14B	8555	broad.mit.edu	37	9	99327506	99327507	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:99327506_99327507delTT	uc004awj.2	-						CDC14B_uc004awk.2_Intron|CDC14B_uc004awl.2_Intron|CDC14B_uc004awi.2_Intron	NM_033331	NP_201588			CDC14 homolog B isoform 2						activation of anaphase-promoting complex activity|DNA repair|G2/M transition DNA damage checkpoint	nucleolus|nucleoplasm	protein binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)	1		Acute lymphoblastic leukemia(62;0.0559)																---	---	---	---
TSTD2	158427	broad.mit.edu	37	9	100389583	100389584	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:100389583_100389584delTT	uc004axn.2	-						TSTD2_uc004axo.2_Intron|TSTD2_uc004axp.1_5'Flank	NM_139246	NP_640339			thiosulfate sulfurtransferase (rhodanese)-like											ovary(2)	2																		---	---	---	---
TRIM14	9830	broad.mit.edu	37	9	100840335	100840335	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:100840335delC	uc004ayd.2	-						NANS_uc004ayb.2_Intron|NANS_uc004ayc.2_Intron|NANS_uc004aye.1_5'Flank	NM_033220	NP_150089			tripartite motif protein TRIM14 isoform alpha							cytoplasm|intracellular	zinc ion binding			central_nervous_system(1)	1		Acute lymphoblastic leukemia(62;0.0559)																---	---	---	---
ANKS6	203286	broad.mit.edu	37	9	101536043	101536043	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:101536043delA	uc004ayu.2	-						ANKS6_uc004ayt.2_Intron|ANKS6_uc004ayv.1_Intron|ANKS6_uc004ayw.1_Intron|ANKS6_uc004ayx.1_Intron|ANKS6_uc004ayy.1_Intron	NM_173551	NP_775822			ankyrin repeat and sterile alpha motif domain											ovary(2)	2		Acute lymphoblastic leukemia(62;0.0527)																---	---	---	---
COL15A1	1306	broad.mit.edu	37	9	101806909	101806909	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:101806909delG	uc004azb.1	+	25	2840	c.2634delG	c.(2632-2634)ATGfs	p.M878fs		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	878	Nonhelical region 5 (NC5).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)																---	---	---	---
Unknown	0	broad.mit.edu	37	9	102150441	102150441	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:102150441delA								SEC61B (157541 upstream) : NR4A3 (433696 downstream)																																			---	---	---	---
TEX10	54881	broad.mit.edu	37	9	103083927	103083928	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:103083927_103083928insT	uc004bas.2	-						TEX10_uc011lvf.1_Intron|TEX10_uc011lvg.1_Intron	NM_017746	NP_060216			testis expressed 10 isoform 1							integral to membrane|MLL1 complex|nuclear membrane|nucleolus	binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)														---	---	---	---
TMEFF1	8577	broad.mit.edu	37	9	103323954	103323954	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:103323954delA	uc004baz.1	+						TMEFF1_uc004bay.1_Intron	NM_003692	NP_003683			transmembrane protein with EGF-like and two						multicellular organismal development	integral to membrane|plasma membrane					0		Acute lymphoblastic leukemia(62;0.0452)																---	---	---	---
RAD23B	5887	broad.mit.edu	37	9	110081279	110081279	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:110081279delT	uc004bde.2	+						RAD23B_uc011lwa.1_Intron|RAD23B_uc011lwb.1_Intron	NM_002874	NP_002865			UV excision repair protein RAD23 homolog B						nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|nucleoplasm|proteasome complex|XPC complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding			ovary(1)	1													Direct_reversal_of_damage|NER					---	---	---	---
IKBKAP	8518	broad.mit.edu	37	9	111680022	111680022	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:111680022delT	uc004bdm.3	-						IKBKAP_uc004bdl.2_5'UTR|IKBKAP_uc011lwc.1_Intron|IKBKAP_uc010mtq.2_Intron	NM_003640	NP_003631			inhibitor of kappa light polypeptide gene						immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	7																		---	---	---	---
PTPN3	5774	broad.mit.edu	37	9	112172142	112172142	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:112172142delC	uc004bed.2	-						PTPN3_uc004beb.2_Intron|PTPN3_uc004bec.2_Intron|PTPN3_uc010mtu.2_Intron|PTPN3_uc011lwg.1_Intron|PTPN3_uc011lwh.1_Intron|PTPN3_uc011lwd.1_Intron|PTPN3_uc011lwe.1_Intron|PTPN3_uc011lwf.1_Intron	NM_002829	NP_002820			protein tyrosine phosphatase, non-receptor type						negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(3)	3																		---	---	---	---
C9orf84	158401	broad.mit.edu	37	9	114520479	114520479	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:114520479delA	uc004bfr.2	-						C9orf84_uc011lwt.1_Intron|C9orf84_uc004bfs.1_Intron|C9orf84_uc004bfq.2_Intron|C9orf84_uc010mug.2_Intron	NM_173521	NP_775792			hypothetical protein LOC158401 isoform 1											ovary(2)	2																		---	---	---	---
KIAA1958	158405	broad.mit.edu	37	9	115336232	115336232	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:115336232delT	uc004bgf.1	+						KIAA1958_uc011lwx.1_Intron	NM_133465	NP_597722			hypothetical protein LOC158405											skin(1)	1																		---	---	---	---
C9orf80	58493	broad.mit.edu	37	9	115451949	115451949	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:115451949delT	uc004bgg.2	-						C9orf80_uc010muk.2_Intron	NM_021218	NP_067041			SOSSC protein						DNA repair|response to ionizing radiation	SOSS complex	protein binding				0																		---	---	---	---
FKBP15	23307	broad.mit.edu	37	9	115969629	115969629	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:115969629delT	uc004bgs.2	-						FKBP15_uc010muu.1_Intron|FKBP15_uc011lxd.1_Intron|FKBP15_uc010mut.1_Intron|FKBP15_uc004bgt.2_Intron	NM_015258	NP_056073			FK506 binding protein 15, 133kDa						endocytosis|protein folding	axon|early endosome	actin binding			ovary(3)	3																		---	---	---	---
RGS3	5998	broad.mit.edu	37	9	116246637	116246637	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:116246637delA	uc004bhq.2	+						RGS3_uc004bhr.2_Intron|RGS3_uc004bhs.2_Intron	NM_144488	NP_652759			regulator of G-protein signalling 3 isoform 6						inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3																		---	---	---	---
ASTN2	23245	broad.mit.edu	37	9	119748440	119748440	+	Intron	DEL	C	-	-	rs34599827		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:119748440delC	uc004bjs.1	-						ASTN2_uc004bjr.1_Intron|ASTN2_uc004bjt.1_Intron	NM_198187	NP_937830			astrotactin 2 isoform c							integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9																		---	---	---	---
C5	727	broad.mit.edu	37	9	123777594	123777594	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:123777594delA	uc004bkv.2	-						C5_uc010mvm.1_Intron|C5_uc010mvn.1_Intron	NM_001735	NP_001726			complement component 5 preproprotein						activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)													---	---	---	---
RAB14	51552	broad.mit.edu	37	9	123945493	123945493	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:123945493delA	uc004blc.2	-							NM_016322	NP_057406			GTPase Rab14						embryo development|fibroblast growth factor receptor signaling pathway|Golgi to endosome transport|neurotransmitter secretion|protein transport|small GTPase mediated signal transduction	cytosol|early endosome membrane|Golgi membrane|Golgi stack|late endosome|lysosome|membrane fraction|nuclear outer membrane-endoplasmic reticulum membrane network|perinuclear region of cytoplasm|rough endoplasmic reticulum|trans-Golgi network transport vesicle	GDP binding|GTP binding|GTPase activity				0																		---	---	---	---
RABGAP1	23637	broad.mit.edu	37	9	125861041	125861042	+	Frame_Shift_Ins	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:125861041_125861042insA	uc011lzh.1	+	23	2915_2916	c.2781_2782insA	c.(2779-2784)ATTAAAfs	p.I927fs	RABGAP1_uc004bnl.3_RNA|RABGAP1_uc011lzj.1_Frame_Shift_Ins_p.I266fs	NM_012197	NP_036329	Q9Y3P9	RBGP1_HUMAN	RAB GTPase activating protein 1	927_928	Potential.				cell cycle	centrosome|cytosol|microtubule associated complex	Rab GTPase activator activity|tubulin binding			ovary(3)|kidney(2)	5																		---	---	---	---
NR6A1	2649	broad.mit.edu	37	9	127360927	127360934	+	Intron	DEL	AAAAAAAA	-	-	rs137950041		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:127360927_127360934delAAAAAAAA	uc004bor.1	-						NR6A1_uc004boq.1_Intron|NR6A1_uc010mwq.1_Intron	NM_033334	NP_201591			nuclear receptor subfamily 6, group A, member 1						cell proliferation|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	transcription factor complex	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(3)	3																		---	---	---	---
Unknown	0	broad.mit.edu	37	9	128184665	128184665	+	IGR	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:128184665delC								GAPVD1 (57376 upstream) : MAPKAP1 (15009 downstream)																																			---	---	---	---
GARNL3	84253	broad.mit.edu	37	9	130076035	130076035	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:130076035delA	uc011mae.1	+						GARNL3_uc011mad.1_Intron	NM_032293	NP_115669			GTPase activating Rap/RanGAP domain-like 3						regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			ovary(1)|central_nervous_system(1)|skin(1)	3																		---	---	---	---
ST6GALNAC4	27090	broad.mit.edu	37	9	130672340	130672340	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:130672340delG	uc004bss.2	-						ST6GALNAC4_uc004bst.2_Intron	NM_175039	NP_778204			sialyltransferase 7D isoform a						glycolipid metabolic process|protein glycosylation	integral to Golgi membrane|nucleus|soluble fraction	(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity				0																		---	---	---	---
DNM1	1759	broad.mit.edu	37	9	130988357	130988357	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:130988357delA	uc011mau.1	+						DNM1_uc010mxr.2_Frame_Shift_Del_p.K414fs|DNM1_uc011mat.1_Intron	NM_004408	NP_004399			dynamin 1 isoform 1						receptor-mediated endocytosis	microtubule	GTP binding|GTPase activity			ovary(2)	2																		---	---	---	---
GOLGA2	2801	broad.mit.edu	37	9	131025242	131025242	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131025242delC	uc011maw.1	-						GOLGA2_uc010mxw.2_Intron|GOLGA2_uc004buh.2_5'Flank|GOLGA2_uc004bul.1_Intron|uc004bun.2_5'Flank	NM_004486	NP_004477			Golgi autoantigen, golgin subfamily a, 2							Golgi cisterna membrane	protein binding			ovary(1)	1																		---	---	---	---
SPTAN1	6709	broad.mit.edu	37	9	131347884	131347884	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131347884delA	uc004bvl.3	+						SPTAN1_uc011mbg.1_Intron|SPTAN1_uc011mbh.1_Intron|SPTAN1_uc004bvm.3_Intron|SPTAN1_uc004bvn.3_Intron	NM_003127	NP_003118			spectrin, alpha, non-erythrocytic 1						actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10																		---	---	---	---
WDR34	89891	broad.mit.edu	37	9	131397627	131397627	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131397627delA	uc004bvq.1	-						WDR34_uc004bvs.1_Intron|WDR34_uc004bvr.1_Intron	NM_052844	NP_443076			WD repeat domain 34							cytoplasm				central_nervous_system(2)|skin(1)	3																OREG0019522	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
C9orf114	51490	broad.mit.edu	37	9	131588911	131588912	+	Intron	INS	-	GA	GA			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131588911_131588912insGA	uc004bwd.2	-						C9orf114_uc004bwe.2_Intron|C9orf114_uc010mym.2_Intron	NM_016390	NP_057474			hypothetical protein LOC51490												0																		---	---	---	---
CCBL1	883	broad.mit.edu	37	9	131597418	131597419	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131597418_131597419delAA	uc004bwh.2	-						CCBL1_uc004bwf.2_Intron|CCBL1_uc004bwg.2_Intron|CCBL1_uc010myn.2_Intron|CCBL1_uc004bwj.2_Intron|CCBL1_uc011mbl.1_Intron|CCBL1_uc004bwi.2_Intron|CCBL1_uc010myo.2_Intron	NM_004059	NP_004050			kynurenine aminotransferase I isoform a						kynurenine metabolic process|L-phenylalanine catabolic process|tryptophan catabolic process	cytosol|nucleus	1-aminocyclopropane-1-carboxylate synthase activity|cysteine-S-conjugate beta-lyase activity|glutamine-phenylpyruvate transaminase activity|kynurenine-oxoglutarate transaminase activity|L-glutamine:pyruvate aminotransferase activity|L-phenylalanine:pyruvate aminotransferase activity|protein homodimerization activity|pyridoxal phosphate binding			ovary(1)	1					L-Glutamine(DB00130)|Pyridoxal Phosphate(DB00114)													---	---	---	---
GPR107	57720	broad.mit.edu	37	9	132848815	132848815	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:132848815delT	uc004bze.2	+						GPR107_uc004bzb.2_Intron|GPR107_uc004bzc.3_Intron|GPR107_uc011mbx.1_Intron|GPR107_uc004bzd.2_Intron	NM_001136557	NP_001130029			G protein-coupled receptor 107 isoform 1							integral to membrane				upper_aerodigestive_tract(1)	1		Ovarian(14;0.000531)																---	---	---	---
FUBP3	8939	broad.mit.edu	37	9	133489868	133489868	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:133489868delA	uc004bzr.1	+						FUBP3_uc010mzd.1_Intron|FUBP3_uc004bzs.1_Intron	NM_003934	NP_003925			far upstream element (FUSE) binding protein 3						positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|RNA binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(145;0.000279)														---	---	---	---
C9orf98	158067	broad.mit.edu	37	9	135695600	135695604	+	Intron	DEL	AAAAA	-	-	rs66490117		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:135695600_135695604delAAAAA	uc004cbu.1	-						C9orf98_uc010mzx.1_Intron|C9orf98_uc004cbv.1_Intron	NM_152572	NP_689785			putative adenylate kinase-like protein C9orf98							cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity				0				OV - Ovarian serous cystadenocarcinoma(145;4.89e-06)|Epithelial(140;0.00016)														---	---	---	---
Unknown	0	broad.mit.edu	37	9	136184772	136184774	+	IGR	DEL	CTG	-	-	rs72449624		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:136184772_136184774delCTG								ABO (34142 upstream) : SURF6 (12779 downstream)																																			---	---	---	---
ADAMTS13	11093	broad.mit.edu	37	9	136302845	136302845	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:136302845delC	uc004cdv.3	+						ADAMTS13_uc004cdp.3_Intron|ADAMTS13_uc004cdt.1_Intron|ADAMTS13_uc004cdu.1_Intron|ADAMTS13_uc004cdw.3_Intron|ADAMTS13_uc004cdx.3_Intron|ADAMTS13_uc004cdy.1_Intron|ADAMTS13_uc004cdz.3_Intron|ADAMTS13_uc004cds.1_Intron|ADAMTS13_uc004cdr.1_Intron	NM_139025	NP_620594			ADAM metallopeptidase with thrombospondin type 1						cell-matrix adhesion|glycoprotein metabolic process|integrin-mediated signaling pathway|peptide catabolic process|platelet activation|protein processing|proteolysis	cell surface|proteinaceous extracellular matrix	calcium ion binding|integrin binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|kidney(1)	6				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)														---	---	---	---
RNU6ATAC	100151684	broad.mit.edu	37	9	137032202	137032203	+	5'Flank	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:137032202_137032203insT	uc010nap.1	-							NR_023344				Homo sapiens RNA, U6atac small nuclear (U12-dependent splicing) (RNU6ATAC), non-coding RNA.												0																		---	---	---	---
KIAA0649	9858	broad.mit.edu	37	9	138378961	138378961	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:138378961delG	uc004cfr.1	+	4	3154	c.2605delG	c.(2605-2607)GGGfs	p.G869fs		NM_014811	NP_055626	Q5T8A7	K0649_HUMAN	1A6/DRIM (down-regulated in metastasis)	869						nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(145;6.91e-08)|Epithelial(140;4.69e-07)|all cancers(34;9.33e-06)														---	---	---	---
GRIN1	2902	broad.mit.edu	37	9	140036496	140036496	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:140036496delC	uc004clk.2	+	2	620	c.290delC	c.(289-291)ACCfs	p.T97fs	GRIN1_uc004cli.1_5'UTR|GRIN1_uc004clj.1_Frame_Shift_Del_p.T94fs|GRIN1_uc004cll.2_Frame_Shift_Del_p.T97fs|GRIN1_uc004clm.2_Frame_Shift_Del_p.T97fs|GRIN1_uc004cln.2_Frame_Shift_Del_p.T94fs|GRIN1_uc004clo.2_Frame_Shift_Del_p.T94fs	NM_007327	NP_015566	Q05586	NMDZ1_HUMAN	NMDA receptor 1 isoform NR1-3 precursor	97	Extracellular (Potential).				ionotropic glutamate receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|regulation of excitatory postsynaptic membrane potential|response to ethanol|visual learning	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane|synaptic vesicle|synaptosome	calcium ion binding|calmodulin binding|extracellular-glutamate-gated ion channel activity|glutamate binding|glycine binding			skin(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;6.87e-05)|Epithelial(140;0.00095)	L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)													---	---	---	---
RNF208	727800	broad.mit.edu	37	9	140115502	140115502	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:140115502delG	uc004clz.1	-	1	274	c.163delC	c.(163-165)CGGfs	p.R55fs		NM_031297	NP_112587	Q9H0X6	RN208_HUMAN	ring finger protein 208	55							zinc ion binding				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)														---	---	---	---
NOXA1	10811	broad.mit.edu	37	9	140327669	140327670	+	Frame_Shift_Ins	INS	-	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:140327669_140327670insG	uc004cmv.2	+	10	998_999	c.863_864insG	c.(862-864)ATGfs	p.M288fs	C9orf167_uc011mew.1_Intron|NOXA1_uc004cmu.2_Frame_Shift_Ins_p.M288fs|NOXA1_uc010nch.2_Frame_Shift_Ins_p.M232fs	NM_006647	NP_006638	Q86UR1	NOXA1_HUMAN	NADPH oxidase activator 1	288			Missing (in NOXA1truncated, a cDNA isolated from Caco-2 cells treated with butyrate).		regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|superoxide metabolic process	cytoplasm|NADPH oxidase complex	Rac GTPase binding|superoxide-generating NADPH oxidase activator activity				0	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000238)|Epithelial(140;0.000982)														---	---	---	---
PFKP	5214	broad.mit.edu	37	10	3162363	3162363	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:3162363delT	uc001igp.2	+						PFKP_uc001igq.2_Intron|PFKP_uc009xhr.2_Intron|PFKP_uc009xhs.1_Intron|PFKP_uc009xht.2_Intron|PFKP_uc009xhu.2_Intron	NM_002627	NP_002618			phosphofructokinase, platelet						glycolysis	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|metal ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3				GBM - Glioblastoma multiforme(1;0.000975)|all cancers(11;0.00351)|Epithelial(11;0.142)												OREG0019976	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
NET1	10276	broad.mit.edu	37	10	5495688	5495689	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:5495688_5495689delAA	uc001iia.2	+						NET1_uc010qar.1_Intron|NET1_uc001iib.2_Intron|NET1_uc010qas.1_Intron	NM_001047160	NP_001040625			neuroepithelial cell transforming gene 1 isoform						apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell growth|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	Rho guanyl-nucleotide exchange factor activity			breast(1)	1																		---	---	---	---
GDI2	2665	broad.mit.edu	37	10	5826928	5826928	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:5826928delT	uc001iil.3	-						GDI2_uc001iim.3_Intron|GDI2_uc009xid.2_Intron	NM_001494	NP_001485			GDP dissociation inhibitor 2 isoform 1						protein transport|small GTPase mediated signal transduction	cell surface|cytosol|membrane	protein binding|Rab GDP-dissociation inhibitor activity				0																		---	---	---	---
SFMBT2	57713	broad.mit.edu	37	10	7249383	7249386	+	Intron	DEL	GAAA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:7249383_7249386delGAAA	uc009xio.1	-						SFMBT2_uc001ijn.1_Intron|SFMBT2_uc010qay.1_Intron	NM_001029880	NP_001025051			Scm-like with four mbt domains 2						regulation of transcription, DNA-dependent	nucleus				ovary(4)|upper_aerodigestive_tract(2)|large_intestine(1)|central_nervous_system(1)	8																		---	---	---	---
ITIH5	80760	broad.mit.edu	37	10	7679010	7679011	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:7679010_7679011delAA	uc001ijq.2	-						ITIH5_uc001ijr.1_Intron	NM_030569	NP_085046			inter-alpha trypsin inhibitor heavy chain						hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4																		---	---	---	---
KIN	22944	broad.mit.edu	37	10	7816627	7816627	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:7816627delA	uc001ijt.2	-						KIN_uc010qaz.1_Intron|KIN_uc009xip.2_Intron|KIN_uc010qba.1_Intron	NM_012311	NP_036443			HsKin17 protein						DNA recombination|DNA repair|DNA replication|interspecies interaction between organisms|mRNA processing	cytoplasm|nuclear matrix	double-stranded DNA binding|RNA binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3																		---	---	---	---
CELF2	10659	broad.mit.edu	37	10	11060019	11060019	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:11060019delC	uc001iki.3	+						CELF2_uc010qbi.1_Intron|CELF2_uc010qbj.1_Intron|CELF2_uc001ikk.2_5'UTR|CELF2_uc001ikl.3_5'UTR	NM_001025077	NP_001020248			CUG triplet repeat, RNA binding protein 2						mRNA processing|regulation of heart contraction	cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding				0																		---	---	---	---
USP6NL	9712	broad.mit.edu	37	10	11567611	11567611	+	Intron	DEL	T	-	-	rs77058930		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:11567611delT	uc001ikt.3	-						USP6NL_uc001iks.1_Intron	NM_014688	NP_055503			USP6 N-terminal like isoform 1							intracellular	Rab GTPase activator activity				0																		---	---	---	---
UPF2	26019	broad.mit.edu	37	10	11963471	11963471	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:11963471delA	uc001ila.2	-						UPF2_uc001ilb.2_Intron|UPF2_uc001ilc.2_Intron	NM_080599	NP_542166			UPF2 regulator of nonsense transcripts homolog						mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			central_nervous_system(2)|ovary(1)	3		Renal(717;0.228)																---	---	---	---
OPTN	10133	broad.mit.edu	37	10	13151192	13151192	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:13151192delC	uc001ilu.1	+	4	508	c.70delC	c.(70-72)CCCfs	p.P24fs	OPTN_uc001ilv.1_Frame_Shift_Del_p.P24fs|OPTN_uc001ilw.1_Frame_Shift_Del_p.P24fs|OPTN_uc001ilx.1_Frame_Shift_Del_p.P24fs|OPTN_uc001ily.1_Frame_Shift_Del_p.P24fs|OPTN_uc010qbr.1_5'UTR|OPTN_uc001ilz.1_Frame_Shift_Del_p.P24fs	NM_001008213	NP_001008214	Q96CV9	OPTN_HUMAN	optineurin	24					cell death|Golgi ribbon formation|Golgi to plasma membrane protein transport|protein targeting to Golgi|signal transduction	perinuclear region of cytoplasm|trans-Golgi network	protein C-terminus binding			ovary(2)	2																		---	---	---	---
SEPHS1	22929	broad.mit.edu	37	10	13365060	13365060	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:13365060delG	uc001imk.2	-						SEPHS1_uc001imh.2_Intron|SEPHS1_uc010qbs.1_Intron|SEPHS1_uc001imi.2_Intron|SEPHS1_uc001imj.2_Intron|SEPHS1_uc010qbt.1_Intron	NM_012247	NP_036379			selenophosphate synthetase 1						protein modification process		ATP binding|GTP binding|selenide, water dikinase activity			skin(1)	1																		---	---	---	---
DCLRE1C	64421	broad.mit.edu	37	10	14943277	14943278	+	Intron	DEL	AC	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:14943277_14943278delAC	uc010qbx.1	-						SUV39H2_uc001ing.2_Intron|SUV39H2_uc001inh.2_Intron|SUV39H2_uc001ini.2_Intron|SUV39H2_uc001inj.2_Intron	NM_001033855	NP_001029027			artemis protein isoform a						DNA recombination	nucleus	5'-3' exonuclease activity|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)	1													Involved_in_tolerance_or_repair_of_DNA_crosslinks|NHEJ					---	---	---	---
DCLRE1C	64421	broad.mit.edu	37	10	14950433	14950433	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:14950433delT	uc001inn.2	-	14	2138	c.2053delA	c.(2053-2055)AGAfs	p.R685fs	DCLRE1C_uc010qbx.1_Intron|DCLRE1C_uc001ink.2_Frame_Shift_Del_p.R338fs|DCLRE1C_uc001inl.2_Frame_Shift_Del_p.R565fs|DCLRE1C_uc009xji.2_Frame_Shift_Del_p.R570fs|DCLRE1C_uc001inm.2_Frame_Shift_Del_p.R565fs|DCLRE1C_uc001ino.2_Frame_Shift_Del_p.R570fs|DCLRE1C_uc009xjh.2_RNA|DCLRE1C_uc001inp.2_Frame_Shift_Del_p.R565fs|DCLRE1C_uc001inq.2_Frame_Shift_Del_p.R565fs|DCLRE1C_uc001inr.2_Frame_Shift_Del_p.R570fs	NM_001033855	NP_001029027	Q96SD1	DCR1C_HUMAN	artemis protein isoform a	685					DNA recombination	nucleus	5'-3' exonuclease activity|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)	1													Involved_in_tolerance_or_repair_of_DNA_crosslinks|NHEJ					---	---	---	---
FAM188A	80013	broad.mit.edu	37	10	15885111	15885111	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:15885111delA	uc001iod.1	-						FAM188A_uc001ioe.1_Intron|FAM188A_uc001iof.1_Intron	NM_024948	NP_079224			chromosome 10 open reading frame 97						apoptosis	nucleus	calcium ion binding			ovary(1)	1																		---	---	---	---
CUBN	8029	broad.mit.edu	37	10	17146613	17146613	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:17146613delA	uc001ioo.2	-							NM_001081	NP_001072			cubilin precursor						cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)													---	---	---	---
VIM	7431	broad.mit.edu	37	10	17277960	17277960	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:17277960delT	uc001iou.2	+						VIM_uc001iov.1_Intron|VIM_uc001iow.1_Intron|VIM_uc001iox.1_Intron|VIM_uc001ioy.1_Intron|VIM_uc001ioz.1_Intron|VIM_uc001ipb.1_Intron|VIM_uc009xjv.1_Intron|VIM_uc001ipc.1_Intron	NM_003380	NP_003371			vimentin						cellular component disassembly involved in apoptosis|cellular component movement|interspecies interaction between organisms|muscle filament sliding	cytosol|intermediate filament	protein C-terminus binding|structural constituent of cytoskeleton			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4																		---	---	---	---
STAM	8027	broad.mit.edu	37	10	17747187	17747187	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:17747187delT	uc001ipj.1	+						STAM_uc009xjw.1_Intron	NM_003473	NP_003464			signal transducing adaptor molecule 1						cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	SH3/SH2 adaptor activity			large_intestine(1)|ovary(1)	2																		---	---	---	---
MRC1	4360	broad.mit.edu	37	10	17875549	17875549	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:17875549delA	uc001ipk.2	+							NM_002438	NP_002429			mannose receptor C type 1 precursor						receptor-mediated endocytosis	endosome membrane|integral to plasma membrane	mannose binding|receptor activity				0																		---	---	---	---
CACNB2	783	broad.mit.edu	37	10	18816362	18816363	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:18816362_18816363insA	uc001ipr.2	+						CACNB2_uc009xjz.1_Intron|CACNB2_uc001ips.2_Intron|CACNB2_uc001ipt.2_Intron|CACNB2_uc010qcl.1_Intron|CACNB2_uc001ipu.2_Intron|CACNB2_uc001ipv.2_Intron|CACNB2_uc009xka.1_Intron|CACNB2_uc001ipw.2_Intron|CACNB2_uc001ipx.2_Intron|CACNB2_uc001ipz.2_Intron|CACNB2_uc001ipy.2_Intron|CACNB2_uc010qco.1_Intron|CACNB2_uc001iqa.2_Intron|NSUN6_uc001iqb.2_Intron	NM_201596	NP_963890			calcium channel, voltage-dependent, beta 2						axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			large_intestine(1)|central_nervous_system(1)|skin(1)	3					Magnesium Sulfate(DB00653)|Verapamil(DB00661)													---	---	---	---
PLXDC2	84898	broad.mit.edu	37	10	20335732	20335732	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:20335732delT	uc001iqg.1	+						PLXDC2_uc001iqh.1_Intron	NM_032812	NP_116201			plexin domain containing 2 precursor							integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4																		---	---	---	---
BMI1	648	broad.mit.edu	37	10	22607014	22607014	+	5'Flank	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:22607014delT	uc001irh.2	+						COMMD3_uc001ire.2_Intron|COMMD3_uc001irf.2_Intron|COMMD3_uc001irg.2_Intron|BMI1_uc009xkg.2_Intron	NM_005180	NP_005171			BMI1 polycomb ring finger oncogene						hemopoiesis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fibroblast proliferation|positive regulation of ubiquitin-protein ligase activity|segment specification|transcription, DNA-dependent	cytoplasm|nucleolus|PcG protein complex|ubiquitin ligase complex	RING-like zinc finger domain binding|zinc ion binding			ovary(1)|skin(1)	2																		---	---	---	---
MYO3A	53904	broad.mit.edu	37	10	26457756	26457756	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:26457756delA	uc001isn.2	+	28	3587	c.3227delA	c.(3226-3228)CAAfs	p.Q1076fs	MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1076	IQ 1.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18																		---	---	---	---
ABI1	10006	broad.mit.edu	37	10	27112339	27112339	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:27112339delA	uc001isx.2	-						ABI1_uc001ite.2_Intron|ABI1_uc010qdh.1_Intron|ABI1_uc010qdi.1_Intron|ABI1_uc001isy.2_Intron|ABI1_uc001ita.2_Intron|ABI1_uc001isz.2_Intron|ABI1_uc001itb.2_Intron|ABI1_uc001itc.2_Intron|ABI1_uc010qdj.1_Intron|ABI1_uc001itd.2_Intron|ABI1_uc010qdk.1_Intron	NM_005470	NP_005461			abl-interactor 1 isoform a						actin polymerization or depolymerization|cellular component movement|negative regulation of cell proliferation|peptidyl-tyrosine phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	cell junction|cytoskeleton|cytosol|endoplasmic reticulum|filopodium|growth cone|lamellipodium|nucleus|soluble fraction|synapse|synaptosome	cytoskeletal protein binding			central_nervous_system(1)	1																		---	---	---	---
MASTL	84930	broad.mit.edu	37	10	27470152	27470152	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:27470152delA	uc001itm.2	+						MASTL_uc001itl.2_Intron|MASTL_uc009xkw.1_Intron|MASTL_uc009xkx.1_Intron	NM_032844	NP_116233			microtubule associated serine/threonine						cell division|G2/M transition of mitotic cell cycle|mitosis|negative regulation of protein phosphatase type 2A activity|regulation of cell cycle|response to DNA damage stimulus	centrosome|cleavage furrow|nucleus	ATP binding|protein phosphatase 2A binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3																		---	---	---	---
ZEB1	6935	broad.mit.edu	37	10	31791266	31791266	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:31791266delT	uc001ivs.3	+						ZEB1_uc001ivr.3_Intron|ZEB1_uc010qee.1_Intron|ZEB1_uc010qef.1_Intron|ZEB1_uc009xlh.1_Intron|ZEB1_uc009xli.1_Intron|ZEB1_uc009xlj.1_Intron|ZEB1_uc010qeg.1_Intron|ZEB1_uc009xlk.1_Intron|ZEB1_uc001ivt.3_Intron|ZEB1_uc001ivu.3_Intron|ZEB1_uc001ivv.3_Intron|ZEB1_uc010qeh.1_Intron|ZEB1_uc009xll.2_Intron|ZEB1_uc009xlm.1_Intron|ZEB1_uc009xln.1_Intron|ZEB1_uc009xlo.1_Intron|ZEB1_uc009xlp.2_Intron	NM_030751	NP_110378			zinc finger E-box binding homeobox 1 isoform b						cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(3)|central_nervous_system(2)	5		Prostate(175;0.0156)																---	---	---	---
Unknown	0	broad.mit.edu	37	10	32404710	32404710	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:32404710delT								KIF5B (59339 upstream) : EPC1 (153149 downstream)																																			---	---	---	---
EPC1	80314	broad.mit.edu	37	10	32575774	32575774	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:32575774delA	uc001iwg.1	-						EPC1_uc001iwi.3_Intron|EPC1_uc009xlt.2_Intron|EPC1_uc001iwh.1_Intron	NM_025209	NP_079485			enhancer of polycomb 1						histone H2A acetylation|histone H4 acetylation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear membrane|Piccolo NuA4 histone acetyltransferase complex				ovary(3)|central_nervous_system(1)	4		Prostate(175;0.0199)																---	---	---	---
PARD3	56288	broad.mit.edu	37	10	34572884	34572885	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:34572884_34572885delTT	uc010qej.1	-						PARD3_uc010qek.1_Intron|PARD3_uc010qel.1_Intron|PARD3_uc010qem.1_Intron|PARD3_uc010qen.1_Intron|PARD3_uc010qeo.1_Intron|PARD3_uc010qep.1_Intron|PARD3_uc010qeq.1_Intron	NM_019619	NP_062565			partitioning-defective protein 3 homolog						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)																---	---	---	---
PARD3	56288	broad.mit.edu	37	10	34964778	34964779	+	Intron	DEL	CA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:34964778_34964779delCA	uc010qej.1	-						PARD3_uc010qek.1_Intron|PARD3_uc010qel.1_Intron|PARD3_uc010qem.1_Intron|PARD3_uc010qen.1_Intron|PARD3_uc010qeo.1_Intron|PARD3_uc010qep.1_Intron|PARD3_uc010qeq.1_Intron|PARD3_uc001ixq.1_Intron|PARD3_uc001ixr.1_Intron|PARD3_uc001ixu.1_Intron	NM_019619	NP_062565			partitioning-defective protein 3 homolog						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)																---	---	---	---
Unknown	0	broad.mit.edu	37	10	42672240	42672241	+	IGR	INS	-	TAAG	TAAG	rs71529068		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:42672240_42672241insTAAG								None (None upstream) : LOC441666 (155074 downstream)																																			---	---	---	---
ZNF22	7570	broad.mit.edu	37	10	45498706	45498706	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:45498706delT	uc001jbw.2	+						C10orf25_uc010qff.1_5'Flank|C10orf25_uc001jbv.1_5'Flank|uc001jbx.1_RNA	NM_006963	NP_008894			zinc finger protein 22 (KOX 15)						odontogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|plasma membrane	DNA binding|zinc ion binding			breast(1)|kidney(1)	2		Prostate(175;0.0352)|all_neural(218;0.202)																---	---	---	---
Unknown	0	broad.mit.edu	37	10	45687313	45687313	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:45687313delT								LOC100133308 (37269 upstream) : OR13A1 (110789 downstream)																																			---	---	---	---
AGAP7	653268	broad.mit.edu	37	10	51465538	51465538	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:51465538delT	uc001jio.2	-	7	1044	c.918delA	c.(916-918)AAAfs	p.K306fs	PARG_uc001jih.2_Intron|uc010qha.1_Intron|uc001jin.2_Intron|uc010qhb.1_Intron|uc010qhc.1_Intron	NM_001077685	NP_001071153	Q5VUJ5	AGAP7_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	306	PH.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding				0																		---	---	---	---
PRKG1	5592	broad.mit.edu	37	10	53387680	53387680	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:53387680delC	uc001jjm.2	+						PRKG1_uc001jjn.2_Intron|PRKG1_uc001jjo.2_Intron	NM_001098512	NP_001091982			protein kinase, cGMP-dependent, type I isoform						actin cytoskeleton organization|platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			lung(2)|stomach(1)|ovary(1)|central_nervous_system(1)|skin(1)	6		all_cancers(4;2.13e-08)|all_epithelial(4;2.44e-08)|all_lung(4;0.000173)		all cancers(4;1.18e-05)|GBM - Glioblastoma multiforme(4;0.000359)|Epithelial(53;0.00532)|Lung(62;0.0606)														---	---	---	---
PRKG1	5592	broad.mit.edu	37	10	54040479	54040479	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:54040479delA	uc001jjm.2	+						PRKG1_uc001jjo.2_Intron|PRKG1_uc009xow.1_Intron|uc001jjq.1_Intron	NM_001098512	NP_001091982			protein kinase, cGMP-dependent, type I isoform						actin cytoskeleton organization|platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			lung(2)|stomach(1)|ovary(1)|central_nervous_system(1)|skin(1)	6		all_cancers(4;2.13e-08)|all_epithelial(4;2.44e-08)|all_lung(4;0.000173)		all cancers(4;1.18e-05)|GBM - Glioblastoma multiforme(4;0.000359)|Epithelial(53;0.00532)|Lung(62;0.0606)														---	---	---	---
PCDH15	65217	broad.mit.edu	37	10	55944777	55944777	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:55944777delT	uc001jju.1	-						PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qhs.1_Intron|PCDH15_uc010qht.1_Intron|PCDH15_uc010qhu.1_Intron|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Intron|PCDH15_uc010qhw.1_Intron|PCDH15_uc010qhx.1_Intron|PCDH15_uc010qhy.1_Intron|PCDH15_uc010qhz.1_Intron|PCDH15_uc010qia.1_Intron|PCDH15_uc010qib.1_Intron|PCDH15_uc001jjw.2_Intron	NM_033056	NP_149045			protocadherin 15 isoform CD1-4 precursor						equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)													HNSCC(58;0.16)			---	---	---	---
PCDH15	65217	broad.mit.edu	37	10	55945034	55945034	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:55945034delA	uc001jju.1	-						PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qhs.1_Intron|PCDH15_uc010qht.1_Intron|PCDH15_uc010qhu.1_Intron|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Intron|PCDH15_uc010qhw.1_Intron|PCDH15_uc010qhx.1_Intron|PCDH15_uc010qhy.1_Intron|PCDH15_uc010qhz.1_Intron|PCDH15_uc010qia.1_Intron|PCDH15_uc010qib.1_Intron|PCDH15_uc001jjw.2_Intron	NM_033056	NP_149045			protocadherin 15 isoform CD1-4 precursor						equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)													HNSCC(58;0.16)			---	---	---	---
Unknown	0	broad.mit.edu	37	10	59317935	59317935	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:59317935delA								None (None upstream) : IPMK (637683 downstream)																																			---	---	---	---
SLC16A9	220963	broad.mit.edu	37	10	61444172	61444172	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:61444172delA	uc010qig.1	-							NM_194298	NP_919274			solute carrier family 16 (monocarboxylic acid						urate metabolic process	integral to membrane|plasma membrane	symporter activity			skin(2)|ovary(1)	3																		---	---	---	---
ANK3	288	broad.mit.edu	37	10	61893881	61893882	+	Intron	INS	-	T	T	rs141972925	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:61893881_61893882insT	uc001jky.2	-						ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jla.1_Intron|ANK3_uc001jlb.1_Intron	NM_020987	NP_066267			ankyrin 3 isoform 1						establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19																		---	---	---	---
ARID5B	84159	broad.mit.edu	37	10	63661899	63661899	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:63661899delT	uc001jlt.1	+						ARID5B_uc010qil.1_Intron	NM_032199	NP_115575			AT rich interactive domain 5B (MRF1-like)						liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4	Prostate(12;0.016)|all_hematologic(501;0.215)																	---	---	---	---
RTKN2	219790	broad.mit.edu	37	10	63958219	63958219	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:63958219delA	uc001jlw.2	-						RTKN2_uc009xpf.1_Intron|RTKN2_uc001jlv.2_Intron	NM_145307	NP_660350			rhotekin 2						signal transduction	intracellular					0	Prostate(12;0.0297)|all_hematologic(501;0.215)																	---	---	---	---
ZNF365	22891	broad.mit.edu	37	10	64415396	64415396	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:64415396delT	uc001jmd.1	+						ZNF365_uc001jmc.2_Intron|ZNF365_uc001jme.1_Intron|ZNF365_uc001jmf.1_Intron|ZNF365_uc009xpg.1_Intron	NM_199452	NP_955524			zinc finger protein 365 isoform D											ovary(1)|skin(1)	2	Prostate(12;0.0297)|all_hematologic(501;0.228)																	---	---	---	---
JMJD1C	221037	broad.mit.edu	37	10	65140296	65140296	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:65140296delT	uc001jmn.2	-						JMJD1C_uc009xpi.2_Intron|JMJD1C_uc001jmr.1_Intron	NM_032776	NP_116165			jumonji domain containing 1C isoform a						blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)																	---	---	---	---
HERC4	26091	broad.mit.edu	37	10	69705599	69705599	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:69705599delA	uc001jng.3	-						HERC4_uc009xpq.2_Intron|HERC4_uc001jnf.3_Intron|HERC4_uc001jnh.3_Intron|HERC4_uc009xpr.2_Intron|HERC4_uc001jni.3_Intron	NM_022079	NP_071362			hect domain and RLD 4 isoform a						cell differentiation|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|spermatogenesis	cytosol	ubiquitin-protein ligase activity			ovary(1)|breast(1)|skin(1)	3																		---	---	---	---
MYPN	84665	broad.mit.edu	37	10	69926167	69926167	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:69926167delC	uc001jnm.3	+	11	1902	c.1717delC	c.(1717-1719)CCCfs	p.P573fs	MYPN_uc001jnl.1_Frame_Shift_Del_p.P573fs|MYPN_uc001jnn.3_Frame_Shift_Del_p.P298fs|MYPN_uc001jno.3_Frame_Shift_Del_p.P573fs|MYPN_uc009xps.2_Frame_Shift_Del_p.P573fs|MYPN_uc009xpt.2_Frame_Shift_Del_p.P573fs|MYPN_uc010qit.1_Frame_Shift_Del_p.P279fs|MYPN_uc010qiu.1_RNA	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	573						nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5																		---	---	---	---
RUFY2	55680	broad.mit.edu	37	10	70136913	70136913	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:70136913delT	uc001job.2	-						RUFY2_uc001jnz.1_Intron|RUFY2_uc001joa.2_5'UTR	NM_017987	NP_060457			RUN and FYVE domain-containing 2 isoform a							nucleus	metal ion binding			ovary(1)	1																		---	---	---	---
DNA2	1763	broad.mit.edu	37	10	70182521	70182521	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:70182521delA	uc001jof.2	-	15	2593	c.2593delT	c.(2593-2595)TCAfs	p.S865fs	DNA2_uc001jog.1_Intron|DNA2_uc001joh.1_RNA	NM_001080449	NP_001073918	P51530	DNA2L_HUMAN	DNA replication helicase 2 homolog	779					base-excision repair|DNA replication, removal of RNA primer|mitochondrial DNA repair|mitochondrial DNA replication|positive regulation of DNA replication|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	mitochondrial nucleoid|nucleoplasm	5'-flap endonuclease activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|site-specific endodeoxyribonuclease activity, specific for altered base				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	10	70304123	70304123	+	IGR	DEL	T	-	-	rs71716010		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:70304123delT								SLC25A16 (16539 upstream) : TET1 (15994 downstream)																																			---	---	---	---
DDX21	9188	broad.mit.edu	37	10	70741207	70741207	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:70741207delT	uc001jov.1	+						DDX21_uc001jow.1_Intron	NM_004728	NP_004719			DEAD (Asp-Glu-Ala-Asp) box polypeptide 21							nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)	3																		---	---	---	---
HKDC1	80201	broad.mit.edu	37	10	70980320	70980320	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:70980320delA	uc001jpf.3	+							NM_025130	NP_079406			hexokinase domain containing 1						glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			ovary(4)|skin(1)	5																		---	---	---	---
KIAA1274	27143	broad.mit.edu	37	10	72245966	72245967	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:72245966_72245967delTT	uc001jrd.3	+							NM_014431	NP_055246			KIAA1274											ovary(2)|central_nervous_system(1)	3																		---	---	---	---
PCBD1	5092	broad.mit.edu	37	10	72644720	72644720	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:72644720delT	uc001jrn.1	-							NM_000281	NP_000272			pterin-4 alpha-carbinolamine						L-phenylalanine catabolic process|regulation of transcription, DNA-dependent|tetrahydrobiopterin biosynthetic process|transcription, DNA-dependent	cytosol|nucleus	4-alpha-hydroxytetrahydrobiopterin dehydratase activity|identical protein binding|transcription coactivator activity				0																		---	---	---	---
CDH23	64072	broad.mit.edu	37	10	73567018	73567018	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:73567018delC	uc001jrx.3	+						CDH23_uc001jsg.3_Intron|CDH23_uc001jsh.3_Intron|CDH23_uc001jsi.3_Intron	NM_022124	NP_071407			cadherin-like 23 isoform 1 precursor						calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11																		---	---	---	---
ASCC1	51008	broad.mit.edu	37	10	73887716	73887716	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:73887716delA	uc001jst.1	-						ASCC1_uc001jsr.1_Intron|ASCC1_uc001jss.1_Intron|ASCC1_uc001jsu.1_Intron|ASCC1_uc010qju.1_Intron					RecName: Full=Activating signal cointegrator 1 complex subunit 1; AltName: Full=ASC-1 complex subunit p50; AltName: Full=Trip4 complex subunit p50;						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	RNA binding				0																		---	---	---	---
ASCC1	51008	broad.mit.edu	37	10	73940733	73940733	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:73940733delT	uc001jst.1	-						ASCC1_uc001jsr.1_Intron|ASCC1_uc001jss.1_Intron|ASCC1_uc001jsu.1_Intron|ASCC1_uc010qju.1_Intron					RecName: Full=Activating signal cointegrator 1 complex subunit 1; AltName: Full=ASC-1 complex subunit p50; AltName: Full=Trip4 complex subunit p50;						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	RNA binding				0																		---	---	---	---
OIT3	170392	broad.mit.edu	37	10	74653469	74653470	+	5'UTR	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:74653469_74653470delAA	uc001jte.1	+	1					OIT3_uc009xqs.1_RNA	NM_152635	NP_689848			oncoprotein-induced transcript 3 precursor							nuclear envelope	calcium ion binding			ovary(2)	2	Prostate(51;0.0198)																	---	---	---	---
MRPS16	51021	broad.mit.edu	37	10	75011301	75011301	+	Intron	DEL	T	-	-	rs113802791		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:75011301delT	uc001jts.1	-						DNAJC9_uc010qkg.1_5'Flank|MRPS16_uc010qkh.1_Intron|MRPS16_uc001jtt.1_Intron|uc001jtu.1_5'Flank	NM_016065	NP_057149			mitochondrial ribosomal protein S16 precursor						translation	mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome				0	Prostate(51;0.0119)																	---	---	---	---
USP54	159195	broad.mit.edu	37	10	75299152	75299152	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:75299152delT	uc001juo.2	-						USP54_uc001jum.2_Intron|USP54_uc001jun.2_Intron|USP54_uc001jup.2_Intron|USP54_uc010qkl.1_Intron|USP54_uc001juq.1_Intron	NM_152586	NP_689799			ubiquitin specific peptidase 54						ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(3)|lung(2)|kidney(1)	6	Prostate(51;0.0112)																	---	---	---	---
NDST2	8509	broad.mit.edu	37	10	75567574	75567575	+	Frame_Shift_Ins	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:75567574_75567575insA	uc001jvk.2	-	3	1376_1377	c.572_573insT	c.(571-573)TTAfs	p.L191fs	NDST2_uc010qks.1_5'Flank|NDST2_uc010qkt.1_Frame_Shift_Ins_p.L68fs|NDST2_uc009xro.2_5'Flank|NDST2_uc010qku.1_Frame_Shift_Ins_p.L68fs	NM_003635	NP_003626	P52849	NDST2_HUMAN	heparan glucosaminyl	191	Lumenal (Potential).|Heparan sulfate N-deacetylase 2.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			ovary(1)	1	Prostate(51;0.0112)																	---	---	---	---
VCL	7414	broad.mit.edu	37	10	75860952	75860952	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:75860952delA	uc001jwd.2	+						VCL_uc009xrr.2_Intron|VCL_uc010qky.1_Intron|VCL_uc001jwe.2_Intron|VCL_uc010qkz.1_Intron	NM_014000	NP_054706			vinculin isoform meta-VCL						adherens junction assembly|apical junction assembly|cell-matrix adhesion|cellular component movement|epithelial cell-cell adhesion|lamellipodium assembly|morphogenesis of an epithelium|muscle contraction|negative regulation of cell migration|platelet activation|platelet degranulation|protein localization at cell surface	costamere|cytosol|extracellular region|focal adhesion	actin binding|alpha-catenin binding|beta-catenin binding|beta-dystroglycan binding|cadherin binding|structural molecule activity		VCL/ALK(4)	kidney(4)|ovary(1)|central_nervous_system(1)	6	Prostate(51;0.0112)																	---	---	---	---
SAMD8	142891	broad.mit.edu	37	10	76928537	76928537	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:76928537delA	uc001jwx.1	+						SAMD8_uc001jwy.1_Intron	NM_144660	NP_653261			sterile alpha motif domain containing 8						sphingomyelin biosynthetic process	integral to membrane					0	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)																	---	---	---	---
KCNMA1	3778	broad.mit.edu	37	10	78869920	78869920	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:78869920delT	uc001jxn.2	-						KCNMA1_uc001jxj.2_Intron|KCNMA1_uc001jxk.1_Intron|KCNMA1_uc009xrt.1_Intron|KCNMA1_uc001jxl.1_Intron|KCNMA1_uc001jxo.2_Intron|KCNMA1_uc001jxm.2_Intron|KCNMA1_uc001jxq.2_Intron	NM_001161352	NP_001154824			large conductance calcium-activated potassium						cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)													---	---	---	---
DYDC1	143241	broad.mit.edu	37	10	82112170	82112170	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:82112170delT	uc001kbx.2	-						DYDC1_uc001kby.1_Intron|DYDC1_uc009xsr.1_Intron|DYDC2_uc001kbz.1_Intron|DYDC2_uc001kca.1_Intron	NM_138812	NP_620167			DPY30 domain containing 1												0			Colorectal(32;0.229)															---	---	---	---
Unknown	0	broad.mit.edu	37	10	86787405	86787405	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:86787405delT								FAM190B (509129 upstream) : GRID1 (571907 downstream)																																			---	---	---	---
MINPP1	9562	broad.mit.edu	37	10	89272866	89272866	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:89272866delT	uc001keu.2	+						MINPP1_uc009xtf.1_Intron|MINPP1_uc001kev.2_Intron	NM_004897	NP_004888			multiple inositol polyphosphate histidine						bone mineralization|polyphosphate metabolic process	endoplasmic reticulum lumen	acid phosphatase activity|bisphosphoglycerate 3-phosphatase activity|multiple inositol-polyphosphate phosphatase activity|phosphohistidine phosphatase activity			urinary_tract(1)	1		Colorectal(252;0.122)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00123)														---	---	---	---
ANKRD22	118932	broad.mit.edu	37	10	90591844	90591844	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:90591844delA	uc001kfj.3	-							NM_144590	NP_653191			ankyrin repeat domain 22												0		Colorectal(252;0.0163)		Colorectal(12;6.29e-05)|COAD - Colon adenocarcinoma(12;7.69e-05)														---	---	---	---
Unknown	0	broad.mit.edu	37	10	93679068	93679068	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:93679068delA								FGFBP3 (9810 upstream) : BTAF1 (4668 downstream)																																			---	---	---	---
BTAF1	9044	broad.mit.edu	37	10	93748896	93748896	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:93748896delT	uc001khr.2	+						BTAF1_uc001khs.1_Intron|BTAF1_uc001kht.1_Intron	NM_003972	NP_003963			BTAF1 RNA polymerase II, B-TFIID transcription						negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)																---	---	---	---
BTAF1	9044	broad.mit.edu	37	10	93770919	93770919	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:93770919delT	uc001khr.2	+							NM_003972	NP_003963			BTAF1 RNA polymerase II, B-TFIID transcription						negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)																---	---	---	---
BTAF1	9044	broad.mit.edu	37	10	93787238	93787238	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:93787238delT	uc001khr.2	+							NM_003972	NP_003963			BTAF1 RNA polymerase II, B-TFIID transcription						negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)																---	---	---	---
IDE	3416	broad.mit.edu	37	10	94268091	94268091	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:94268091delA	uc001kia.2	-							NM_004969	NP_004960			insulin-degrading enzyme isoform 1 precursor						beta-amyloid metabolic process|bradykinin catabolic process|interspecies interaction between organisms|sex differentiation	cell surface|extracellular space|soluble fraction	ATP binding|metalloendopeptidase activity|protein homodimerization activity|signal transducer activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3					Bacitracin(DB00626)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)													---	---	---	---
EXOC6	54536	broad.mit.edu	37	10	94675429	94675429	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:94675429delA	uc001kig.2	+						EXOC6_uc010qnr.1_Intron|EXOC6_uc001kie.2_Intron|EXOC6_uc009xub.2_Intron|EXOC6_uc009xuc.2_Intron	NM_019053	NP_061926			SEC15-like 1 isoform a						protein transport|vesicle docking involved in exocytosis	exocyst				skin(1)	1		Colorectal(252;0.123)																---	---	---	---
LGI1	9211	broad.mit.edu	37	10	95536972	95536973	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:95536972_95536973insA	uc001kjc.3	+						LGI1_uc010qnv.1_Intron|LGI1_uc001kjd.3_Intron|LGI1_uc009xui.2_Intron|LGI1_uc001kje.2_Intron	NM_005097	NP_005088			leucine-rich, glioma inactivated 1 precursor						axon guidance|cell proliferation|positive regulation of cell growth|positive regulation of synaptic transmission	cell junction|extracellular space|synapse	receptor binding			ovary(2)|central_nervous_system(1)|skin(1)	4		Colorectal(252;0.124)																---	---	---	---
NOC3L	64318	broad.mit.edu	37	10	96099440	96099440	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:96099440delA	uc001kjq.1	-							NM_022451	NP_071896			nucleolar complex associated 3 homolog							nuclear speck|nucleolus	binding			ovary(1)	1		Colorectal(252;0.0897)																---	---	---	---
HELLS	3070	broad.mit.edu	37	10	96313731	96313731	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:96313731delT	uc001kjt.2	+						HELLS_uc001kjs.2_Intron|HELLS_uc009xul.2_Intron|HELLS_uc009xum.2_Intron|HELLS_uc009xun.2_Intron|HELLS_uc009xuo.2_Intron|HELLS_uc001kju.2_Intron|HELLS_uc009xup.2_Intron|HELLS_uc009xuq.2_Intron|HELLS_uc009xur.2_Intron	NM_018063	NP_060533			helicase, lymphoid-specific						cell division|centromeric heterochromatin formation|lymphocyte proliferation|maintenance of DNA methylation|methylation-dependent chromatin silencing|mitosis|transcription, DNA-dependent	centromeric heterochromatin|nucleus	ATP binding|DNA binding|helicase activity			ovary(1)|kidney(1)	2		Colorectal(252;0.0429)		all cancers(201;2.13e-05)														---	---	---	---
DNTT	1791	broad.mit.edu	37	10	98088357	98088357	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:98088357delA	uc001kmf.2	+						DNTT_uc001kmg.2_Intron	NM_004088	NP_004079			terminal deoxynucleotidyltransferase isoform 1						DNA modification	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			ovary(1)	1		Colorectal(252;0.0815)|all_hematologic(284;0.224)		Epithelial(162;7.97e-08)|all cancers(201;1.89e-06)														---	---	---	---
TM9SF3	56889	broad.mit.edu	37	10	98312908	98312908	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:98312908delA	uc001kmm.3	-						TM9SF3_uc010qot.1_Intron|TM9SF3_uc001kmn.1_5'Flank	NM_020123	NP_064508			transmembrane 9 superfamily member 3 precursor							integral to membrane	binding				0		Colorectal(252;0.158)		Epithelial(162;1.84e-09)|all cancers(201;2.84e-08)														---	---	---	---
MMS19	64210	broad.mit.edu	37	10	99221731	99221731	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:99221731delA	uc001kns.3	-						MMS19_uc001knq.2_5'Flank|MMS19_uc009xvs.2_Intron|MMS19_uc009xvt.2_Intron|MMS19_uc001knr.2_Intron|MMS19_uc010qox.1_Intron|MMS19_uc001knt.2_Intron|MMS19_uc001knu.1_Intron	NM_022362	NP_071757			MMS19 nucleotide excision repair homolog						chromosome segregation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|response to hormone stimulus|transcription, DNA-dependent|two-component signal transduction system (phosphorelay)	cytoplasm|holo TFIIH complex|MMXD complex	estrogen receptor binding|protein binding, bridging|receptor signaling complex scaffold activity|transcription coactivator activity				0		Colorectal(252;0.0846)		Epithelial(162;3.33e-10)|all cancers(201;2.74e-08)									Direct_reversal_of_damage|NER					---	---	---	---
MMS19	64210	broad.mit.edu	37	10	99226748	99226748	+	Intron	DEL	T	-	-	rs67140194		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:99226748delT	uc001kns.3	-						MMS19_uc009xvs.2_Intron|MMS19_uc009xvt.2_Intron|MMS19_uc001knr.2_Intron|MMS19_uc010qox.1_Intron|MMS19_uc001knt.2_Intron|MMS19_uc001knu.1_Intron	NM_022362	NP_071757			MMS19 nucleotide excision repair homolog						chromosome segregation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|response to hormone stimulus|transcription, DNA-dependent|two-component signal transduction system (phosphorelay)	cytoplasm|holo TFIIH complex|MMXD complex	estrogen receptor binding|protein binding, bridging|receptor signaling complex scaffold activity|transcription coactivator activity				0		Colorectal(252;0.0846)		Epithelial(162;3.33e-10)|all cancers(201;2.74e-08)									Direct_reversal_of_damage|NER					---	---	---	---
Unknown	0	broad.mit.edu	37	10	99823576	99823579	+	IGR	DEL	CTTC	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:99823576_99823579delCTTC								CRTAC1 (32991 upstream) : C10orf28 (70802 downstream)																																			---	---	---	---
CPN1	1369	broad.mit.edu	37	10	101808725	101808725	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:101808725delT	uc001kql.2	-							NM_001308	NP_001299			carboxypeptidase N, polypeptide 1 precursor						proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(3)|pancreas(1)	4		Colorectal(252;0.234)		Epithelial(162;4.77e-10)|all cancers(201;3.82e-08)														---	---	---	---
CHUK	1147	broad.mit.edu	37	10	101969560	101969560	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:101969560delA	uc001kqp.2	-							NM_001278	NP_001269			conserved helix-loop-helix ubiquitous kinase						I-kappaB phosphorylation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|nucleus	ATP binding|identical protein binding|IkappaB kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|breast(1)	7		Colorectal(252;0.117)		Epithelial(162;2.05e-10)|all cancers(201;1.91e-08)														---	---	---	---
SEMA4G	57715	broad.mit.edu	37	10	102734718	102734718	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:102734718delA	uc010qpt.1	+						SEMA4G_uc001krv.2_Intron|SEMA4G_uc001krw.1_Intron|SEMA4G_uc001krx.2_Intron|MIR608_hsa-mir-608|MI0003621_5'Flank	NM_017893	NP_060363			semaphorin 4G						cell differentiation|nervous system development	integral to membrane	receptor activity			breast(1)	1		Colorectal(252;0.234)		Epithelial(162;3.71e-09)|all cancers(201;2.1e-07)														---	---	---	---
TLX1	3195	broad.mit.edu	37	10	102893955	102893955	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:102893955delC	uc001ksw.2	+	2	830	c.592delC	c.(592-594)CCCfs	p.P198fs		NM_005521	NP_005512	P31314	TLX1_HUMAN	T-cell leukemia homeobox 1	198						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1				Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)				T	TRB@|TRD@	T-ALL								---	---	---	---
BTRC	8945	broad.mit.edu	37	10	103310573	103310573	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:103310573delC	uc001kta.2	+	14	1887	c.1774delC	c.(1774-1776)CCCfs	p.P592fs	BTRC_uc001ktb.2_Frame_Shift_Del_p.P556fs|BTRC_uc001ktc.2_Frame_Shift_Del_p.P566fs	NM_033637	NP_378663	Q9Y297	FBW1A_HUMAN	beta-transducin repeat containing protein	592					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|positive regulation of proteolysis|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|viral reproduction|Wnt receptor signaling pathway	cytosol|nucleus|SCF ubiquitin ligase complex				ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;1.05e-08)|all cancers(201;6.59e-07)														---	---	---	---
PPRC1	23082	broad.mit.edu	37	10	103904107	103904109	+	Intron	DEL	CAG	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:103904107_103904109delCAG	uc001kum.2	+						PPRC1_uc001kun.2_Intron|PPRC1_uc010qqj.1_Intron|PPRC1_uc009xxa.2_Intron	NM_015062	NP_055877			peroxisome proliferator-activated receptor						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)														---	---	---	---
PSD	5662	broad.mit.edu	37	10	104167026	104167026	+	Intron	DEL	G	-	-	rs113725792		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:104167026delG	uc001kvg.1	-						PSD_uc001kve.1_5'Flank|PSD_uc001kvf.1_Intron|PSD_uc001kvh.1_Intron|PSD_uc009xxd.1_Intron	NM_002779	NP_002770			pleckstrin and Sec7 domain containing						regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|urinary_tract(1)	3				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)														---	---	---	---
PDCD11	22984	broad.mit.edu	37	10	105159974	105159975	+	Intron	INS	-	C	C	rs146704197	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:105159974_105159975insC	uc001kwy.1	+							NM_014976	NP_055791			programmed cell death 11						mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)														---	---	---	---
SLK	9748	broad.mit.edu	37	10	105752287	105752287	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:105752287delA	uc001kxo.1	+						SLK_uc001kxp.1_Intron	NM_014720	NP_055535			serine/threonine kinase 2						apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			ovary(2)|stomach(2)|skin(2)|lung(1)|kidney(1)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)														---	---	---	---
XPNPEP1	7511	broad.mit.edu	37	10	111651337	111651337	+	Intron	DEL	T	-	-	rs112429910		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:111651337delT	uc001kyp.1	-						XPNPEP1_uc009xxt.1_Intron|XPNPEP1_uc001kyq.1_Intron|XPNPEP1_uc010qrb.1_Intron	NM_020383	NP_065116			X-prolyl aminopeptidase (aminopeptidase P) 1,						bradykinin catabolic process|proteolysis		manganese ion binding|metalloaminopeptidase activity|protein homodimerization activity			ovary(3)|pancreas(1)	4		Breast(234;0.174)		Epithelial(162;1.64e-05)|all cancers(201;0.000564)|BRCA - Breast invasive adenocarcinoma(275;0.0721)														---	---	---	---
ADD3	120	broad.mit.edu	37	10	111882229	111882229	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:111882229delT	uc001kyt.3	+						ADD3_uc001kys.3_Intron|ADD3_uc001kyu.2_Intron|ADD3_uc001kyv.2_Intron|ADD3_uc001kyw.2_Intron|ADD3_uc001kyx.2_5'Flank	NM_016824	NP_058432			adducin 3 (gamma) isoform a							cytoskeleton	actin binding|calmodulin binding|metal ion binding|structural constituent of cytoskeleton			ovary(2)|skin(2)|large_intestine(1)	5		Breast(234;0.052)|Lung NSC(174;0.223)		Epithelial(162;4.15e-05)|all cancers(201;0.000587)|BRCA - Breast invasive adenocarcinoma(275;0.0742)														---	---	---	---
SMC3	9126	broad.mit.edu	37	10	112343399	112343399	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:112343399delT	uc001kze.2	+							NM_005445	NP_005436			structural maintenance of chromosomes 3						cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)														---	---	---	---
PDCD4	27250	broad.mit.edu	37	10	112657698	112657698	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:112657698delA	uc001kzh.2	+						PDCD4_uc001kzg.2_Intron|PDCD4_uc010qre.1_Intron	NM_014456	NP_055271			programmed cell death 4 isoform 1						apoptosis|cell aging|negative regulation of cell cycle|negative regulation of JUN kinase activity|negative regulation of transcription, DNA-dependent	cytosol|nucleus	protein binding|RNA binding			ovary(1)|breast(1)|skin(1)	3		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.000526)|all cancers(201;0.00794)|BRCA - Breast invasive adenocarcinoma(275;0.125)														---	---	---	---
ADRA2A	150	broad.mit.edu	37	10	112839027	112839029	+	In_Frame_Del	DEL	TTC	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:112839027_112839029delTTC	uc001kzo.2	+	1	2238_2240	c.1273_1275delTTC	c.(1273-1275)TTCdel	p.F427del		NM_000681	NP_000672	P08913	ADA2A_HUMAN	alpha-2A-adrenergic receptor	412	Helical; Name=7; (By similarity).			F->N: 350-fold reduced affinity for alpha-2 antagonist yohimbine, 3000-fold increase for beta-antagonist alprenolol.	actin cytoskeleton organization|activation of MAPK activity by adrenergic receptor signaling pathway|activation of phospholipase C activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cellular component movement|cellular response to hormone stimulus|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|glucose homeostasis|inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway|intestinal absorption|negative regulation of adrenergic receptor signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cAMP biosynthetic process|negative regulation of epinephrine secretion|negative regulation of insulin secretion involved in cellular response to glucose stimulus|negative regulation of lipid catabolic process|negative regulation of norepinephrine secretion|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cytokine production|positive regulation of membrane protein ectodomain proteolysis|positive regulation of potassium ion transport|positive regulation of wound healing|Rho protein signal transduction	basolateral plasma membrane|cytoplasm|integral to plasma membrane|receptor complex	alpha-1B adrenergic receptor binding|alpha-2C adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|heterotrimeric G-protein binding|norepinephrine binding|protein heterodimerization activity|protein homodimerization activity|protein kinase binding|thioesterase binding				0		Breast(234;0.0735)|Lung NSC(174;0.238)		Epithelial(162;0.000316)|all cancers(201;0.00501)|BRCA - Breast invasive adenocarcinoma(275;0.118)	Amitriptyline(DB00321)|Amphetamine(DB00182)|Apraclonidine(DB00964)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Brimonidine(DB00484)|Clonidine(DB00575)|Debrisoquin(DB04840)|Dexmedetomidine(DB00633)|Dipivefrin(DB00449)|Epinastine(DB00751)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanabenz(DB00629)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Lofexidine(DB04948)|Methyldopa(DB00968)|Mianserin(DB06148)|Mirtazapine(DB00370)|Norepinephrine(DB00368)|Oxymetazoline(DB00935)|Phentolamine(DB00692)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Tizanidine(DB00697)|Trazodone(DB00656)|Yohimbine(DB01392)													---	---	---	---
GPAM	57678	broad.mit.edu	37	10	113921516	113921516	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:113921516delT	uc009xxy.1	-						GPAM_uc001kzp.2_Intron|GPAM_uc001kzq.1_Intron	NM_020918	NP_065969			mitochondrial glycerol 3-phosphate						phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			ovary(1)|skin(1)	2				Epithelial(162;0.0306)|all cancers(201;0.123)														---	---	---	---
TCF7L2	6934	broad.mit.edu	37	10	114919590	114919595	+	Intron	DEL	CCCCCC	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:114919590_114919595delCCCCCC	uc001lae.3	+						TCF7L2_uc001lac.3_Intron|TCF7L2_uc010qrk.1_Intron|TCF7L2_uc010qrl.1_Intron|TCF7L2_uc010qrm.1_Intron|TCF7L2_uc010qrn.1_Intron|TCF7L2_uc001lad.3_Intron|TCF7L2_uc001lag.3_Intron|TCF7L2_uc001laf.3_Intron|TCF7L2_uc010qro.1_Intron|TCF7L2_uc001lah.2_Intron|TCF7L2_uc010qrp.1_Intron|TCF7L2_uc010qrq.1_Intron|TCF7L2_uc010qrr.1_Intron|TCF7L2_uc010qrs.1_Intron|TCF7L2_uc010qrt.1_Intron|TCF7L2_uc010qru.1_Intron|TCF7L2_uc010qrv.1_Intron|TCF7L2_uc010qrw.1_Intron|TCF7L2_uc010qrx.1_Intron	NM_001146274	NP_001139746			transcription factor 7-like 2 isoform 1						anti-apoptosis|blood vessel development|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell cycle arrest|cell proliferation|fat cell differentiation|glucose homeostasis|maintenance of DNA repeat elements|myoblast cell fate commitment|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|pancreas development|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of insulin secretion|positive regulation of protein binding|positive regulation of protein export from nucleus|positive regulation of protein kinase B signaling cascade|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone metabolic process|regulation of smooth muscle cell proliferation|response to glucose stimulus	beta-catenin-TCF7L2 complex|PML body|protein-DNA complex	armadillo repeat domain binding|beta-catenin binding|gamma-catenin binding|nuclear hormone receptor binding|protein kinase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			large_intestine(3)|ovary(1)	4		Breast(234;0.058)|Colorectal(252;0.0615)		Epithelial(162;0.00554)|all cancers(201;0.02)														---	---	---	---
NRAP	4892	broad.mit.edu	37	10	115391082	115391083	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:115391082_115391083insA	uc001laj.2	-						NRAP_uc009xyb.2_5'Flank|NRAP_uc001lak.2_Intron|NRAP_uc001lal.3_Intron	NM_198060	NP_932326			nebulin-related anchoring protein isoform S							fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			ovary(6)|central_nervous_system(3)|upper_aerodigestive_tract(1)	10		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)														---	---	---	---
VWA2	340706	broad.mit.edu	37	10	116014989	116014989	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:116014989delT	uc001lbl.1	+						VWA2_uc001lbk.1_Intron|VWA2_uc009xyf.1_Intron	NM_198496	NP_940898			von Willebrand factor A domain containing 2							extracellular region				ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5				Epithelial(162;0.036)|all cancers(201;0.0793)														---	---	---	---
ABLIM1	3983	broad.mit.edu	37	10	116197441	116197441	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:116197441delT	uc010qsg.1	-						ABLIM1_uc010qsh.1_Intron|ABLIM1_uc010qsi.1_Intron|ABLIM1_uc010qsf.1_Intron	NM_002313	NP_002304			actin-binding LIM protein 1 isoform a						axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding			breast(1)	1		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)														---	---	---	---
ABLIM1	3983	broad.mit.edu	37	10	116450448	116450448	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:116450448delT	uc001lbz.1	-											Homo sapiens cDNA FLJ25105 fis, clone CBR01442.						axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding			breast(1)	1		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)														---	---	---	---
ATRNL1	26033	broad.mit.edu	37	10	117221591	117221591	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:117221591delT	uc001lcg.2	+						ATRNL1_uc010qsm.1_Intron|ATRNL1_uc010qsn.1_Intron	NM_207303	NP_997186			attractin-like 1 precursor							integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)														---	---	---	---
PNLIP	5406	broad.mit.edu	37	10	118305523	118305523	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:118305523delC	uc001lcm.2	+							NM_000936	NP_000927			pancreatic lipase precursor						lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|skin(1)	3				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)													---	---	---	---
PNLIP	5406	broad.mit.edu	37	10	118307590	118307591	+	Intron	DEL	CA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:118307590_118307591delCA	uc001lcm.2	+							NM_000936	NP_000927			pancreatic lipase precursor						lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|skin(1)	3				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)													---	---	---	---
KIAA1598	57698	broad.mit.edu	37	10	118719757	118719757	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:118719757delA	uc009xyw.2	-						KIAA1598_uc001lcz.3_Intron|KIAA1598_uc010qso.1_Intron|KIAA1598_uc010qsp.1_Intron|KIAA1598_uc010qsq.1_Intron|KIAA1598_uc001lcy.3_Intron	NM_001127211	NP_001120683			shootin1 isoform a						axon guidance	axon					0				all cancers(201;0.00494)														---	---	---	---
TIAL1	7073	broad.mit.edu	37	10	121335157	121335157	+	3'UTR	DEL	T	-	-	rs73366847	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:121335157delT	uc001lei.1	-	12					TIAL1_uc001leh.1_3'UTR|TIAL1_uc001lej.1_3'UTR|TIAL1_uc001lek.1_3'UTR|TIAL1_uc009xzi.1_3'UTR	NM_003252	NP_003243			TIA-1 related protein isoform 1						apoptosis|defense response|induction of apoptosis|regulation of transcription from RNA polymerase II promoter	lysosome|nucleus|stress granule	nucleotide binding|RNA binding			ovary(1)	1		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.00239)|BRCA - Breast invasive adenocarcinoma(275;0.0932)														---	---	---	---
INPP5F	22876	broad.mit.edu	37	10	121566037	121566037	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:121566037delT	uc001leo.2	+							NM_014937	NP_055752			inositol polyphosphate-5-phosphatase F								phosphoric ester hydrolase activity			ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)														---	---	---	---
INPP5F	22876	broad.mit.edu	37	10	121567369	121567369	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:121567369delT	uc001leo.2	+							NM_014937	NP_055752			inositol polyphosphate-5-phosphatase F								phosphoric ester hydrolase activity			ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)														---	---	---	---
TACC2	10579	broad.mit.edu	37	10	123842738	123842738	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:123842738delG	uc001lfv.2	+	4	1083	c.723delG	c.(721-723)CAGfs	p.Q241fs	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Frame_Shift_Del_p.Q241fs|TACC2_uc010qtv.1_Frame_Shift_Del_p.Q241fs	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	241						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)																---	---	---	---
CPXM2	119587	broad.mit.edu	37	10	125514127	125514127	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:125514127delA	uc001lhk.1	-						CPXM2_uc001lhj.2_Intron	NM_198148	NP_937791			carboxypeptidase X (M14 family), member 2						cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)														---	---	---	---
OAT	4942	broad.mit.edu	37	10	126100397	126100404	+	Intron	DEL	AAAAAAAG	-	-	rs148068339		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:126100397_126100404delAAAAAAAG	uc001lhp.2	-						OAT_uc001lhq.2_Intron|OAT_uc001lhr.2_Intron	NM_000274	NP_000265			ornithine aminotransferase precursor						cellular amino acid biosynthetic process|visual perception	mitochondrial matrix	ornithine-oxo-acid transaminase activity|protein binding|pyridoxal phosphate binding				0		all_lung(145;0.0271)|Lung NSC(174;0.0436)|Colorectal(57;0.102)|all_neural(114;0.116)			L-Ornithine(DB00129)|Pyridoxal Phosphate(DB00114)													---	---	---	---
C10orf137	26098	broad.mit.edu	37	10	127426305	127426305	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:127426305delT	uc001liq.1	+						C10orf137_uc001lin.2_Intron|C10orf137_uc001lio.1_Intron|C10orf137_uc001lip.1_Intron|C10orf137_uc001lir.2_Intron|C10orf137_uc001lis.1_5'Flank	NM_015608	NP_056423			erythroid differentiation-related factor 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			ovary(5)|large_intestine(3)|lung(2)	10		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)																---	---	---	---
C10orf137	26098	broad.mit.edu	37	10	127429008	127429008	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:127429008delT	uc001liq.1	+						C10orf137_uc001lin.2_Intron|C10orf137_uc001lio.1_Intron|C10orf137_uc001lip.1_Intron|C10orf137_uc001lir.2_Intron|C10orf137_uc001lis.1_5'Flank	NM_015608	NP_056423			erythroid differentiation-related factor 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			ovary(5)|large_intestine(3)|lung(2)	10		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)																---	---	---	---
BCCIP	56647	broad.mit.edu	37	10	127524551	127524551	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:127524551delT	uc001ljb.3	+						BCCIP_uc001ljd.3_Intron|BCCIP_uc010qui.1_Intron|BCCIP_uc001ljc.3_Intron|BCCIP_uc010quj.1_Intron	NM_078468	NP_510868			BRCA2 and CDKN1A-interacting protein isoform						cell cycle|DNA repair|neuroendocrine cell differentiation|regulation of cyclin-dependent protein kinase activity	nuclear cyclin-dependent protein kinase holoenzyme complex	kinase regulator activity|protein binding			ovary(1)|breast(1)	2		all_lung(145;0.00751)|Lung NSC(174;0.0115)|Colorectal(57;0.0846)|all_neural(114;0.0936)																---	---	---	---
C10orf90	118611	broad.mit.edu	37	10	128114309	128114309	+	3'UTR	DEL	A	-	-	rs144809692		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:128114309delA	uc001ljq.2	-	9					C10orf90_uc001ljp.2_3'UTR|C10orf90_uc010qum.1_3'UTR|C10orf90_uc001ljo.2_RNA	NM_001004298	NP_001004298			hypothetical protein LOC118611											ovary(1)|skin(1)	2		all_epithelial(44;4.51e-05)|all_lung(145;0.0068)|Lung NSC(174;0.0105)|Colorectal(57;0.0848)|all_neural(114;0.0936)|Breast(234;0.203)		COAD - Colon adenocarcinoma(40;0.0442)|Colorectal(40;0.0479)														---	---	---	---
DOCK1	1793	broad.mit.edu	37	10	129237392	129237392	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:129237392delA	uc001ljt.2	+	49	5163	c.5099delA	c.(5098-5100)GAAfs	p.E1700fs	DOCK1_uc010qun.1_Frame_Shift_Del_p.E1721fs|DOCK1_uc009yaq.2_Frame_Shift_Del_p.E695fs	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1700					apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)														---	---	---	---
EPS8L2	64787	broad.mit.edu	37	11	726232	726232	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:726232delG	uc001lqt.2	+						EPS8L2_uc001lqu.2_Intron|EPS8L2_uc010qwk.1_Intron|EPS8L2_uc001lqv.2_Intron|EPS8L2_uc001lqw.2_Intron|EPS8L2_uc001lqx.2_Intron|EPS8L2_uc001lqy.2_Intron	NM_022772	NP_073609			epidermal growth factor receptor pathway							cytoplasm				pancreas(1)	1		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.37e-27)|Epithelial(43;2.81e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-20)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)														---	---	---	---
IGF2	3481	broad.mit.edu	37	11	2167369	2167370	+	Intron	INS	-	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:2167369_2167370insC	uc001lvh.2	-						INS-IGF2_uc001lvi.2_Intron|IGF2AS_uc001lvk.1_Intron|IGF2AS_uc010qxi.1_Intron|IGF2AS_uc001lvl.1_Intron	NM_001007139	NP_001007140			insulin-like growth factor 2 isoform 1						glucose metabolic process|ossification|phosphatidylinositol 3-kinase cascade involved in insulin receptor signaling|positive regulation of activated T cell proliferation|positive regulation of cell division|positive regulation of glycogen (starch) synthase activity|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|skeletal system development	extracellular space	growth factor activity|hormone activity|insulin receptor binding|insulin-like growth factor receptor binding|protein serine/threonine kinase activator activity|receptor activator activity			central_nervous_system(1)	1		all_epithelial(84;5.04e-06)|Breast(177;0.000777)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)|all_lung(207;0.24)	Colorectal(5;0.0179)|COAD - Colon adenocarcinoma(6;0.029)	BRCA - Breast invasive adenocarcinoma(625;1.09e-05)|LUSC - Lung squamous cell carcinoma(625;0.082)|Lung(200;0.153)														---	---	---	---
RRM1	6240	broad.mit.edu	37	11	4141256	4141256	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:4141256delT	uc001lyw.3	+						RRM1_uc009yej.2_Intron|RRM1_uc009yei.2_Intron|RRM1_uc010qyc.1_Intron|RRM1_uc010qyd.1_Intron	NM_001033	NP_001024			ribonucleoside-diphosphate reductase M1 chain						deoxyribonucleotide biosynthetic process|DNA replication|nucleobase, nucleoside and nucleotide interconversion	cytosol|nucleoplasm|ribonucleoside-diphosphate reductase complex	ATP binding|ribonucleoside-diphosphate reductase activity			skin(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.00502)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0848)|LUSC - Lung squamous cell carcinoma(625;0.205)	Clofarabine(DB00631)|Fludarabine(DB01073)|Gemcitabine(DB00441)|Hydroxyurea(DB01005)													---	---	---	---
NRIP3	56675	broad.mit.edu	37	11	9005799	9005799	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:9005799delT	uc001mhg.2	-						NRIP3_uc010rbu.1_Intron	NM_020645	NP_065696			nuclear receptor interacting protein 3						proteolysis		aspartic-type endopeptidase activity				0				Epithelial(150;4.77e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0241)														---	---	---	---
SCUBE2	57758	broad.mit.edu	37	11	9081805	9081805	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:9081805delG	uc001mhh.1	-						SCUBE2_uc001mhi.1_Intron|SCUBE2_uc001mhj.1_Intron	NM_020974	NP_066025			CEGP1 protein precursor							extracellular region	calcium ion binding			ovary(1)|skin(1)	2				all cancers(16;8.57e-09)|Epithelial(150;4.42e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0116)														---	---	---	---
ZNF143	7702	broad.mit.edu	37	11	9493100	9493101	+	Intron	INS	-	T	T	rs7119680	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:9493100_9493101insT	uc001mhr.2	+						ZNF143_uc009yfu.2_Intron|ZNF143_uc010rby.1_Intron	NM_003442	NP_003433			zinc finger protein 143						regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding|zinc ion binding				0				all cancers(16;4.12e-09)|Epithelial(150;2.29e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0212)														---	---	---	---
ZNF143	7702	broad.mit.edu	37	11	9494462	9494464	+	Intron	DEL	TTT	-	-	rs141312409		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:9494462_9494464delTTT	uc001mhr.2	+						ZNF143_uc009yfu.2_Intron|ZNF143_uc010rby.1_Intron	NM_003442	NP_003433			zinc finger protein 143						regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding|zinc ion binding				0				all cancers(16;4.12e-09)|Epithelial(150;2.29e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0212)														---	---	---	---
ZNF143	7702	broad.mit.edu	37	11	9500922	9500923	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:9500922_9500923insT	uc001mhr.2	+						ZNF143_uc009yfu.2_Intron|ZNF143_uc010rby.1_Intron	NM_003442	NP_003433			zinc finger protein 143						regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding|zinc ion binding				0				all cancers(16;4.12e-09)|Epithelial(150;2.29e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0212)														---	---	---	---
WEE1	7465	broad.mit.edu	37	11	9608515	9608516	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:9608515_9608516insT	uc001mhs.2	+						WEE1_uc001mht.2_Intron	NM_003390	NP_003381			WEE1 tyrosine kinase isoform 1						blood coagulation|cell cycle checkpoint|cell division|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|S phase of mitotic cell cycle	nucleoplasm	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)|ovary(1)|breast(1)|skin(1)	5				all cancers(16;4.59e-09)|Epithelial(150;3.15e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0484)														---	---	---	---
TEAD1	7003	broad.mit.edu	37	11	12951569	12951569	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:12951569delT	uc001mkj.3	+						TEAD1_uc001mkk.3_Intron|TEAD1_uc009ygl.2_Intron	NM_021961	NP_068780			TEA domain family member 1						hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0				Epithelial(150;0.00223)|BRCA - Breast invasive adenocarcinoma(625;0.236)														---	---	---	---
COPB1	1315	broad.mit.edu	37	11	14510133	14510133	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:14510133delA	uc001mli.2	-						COPB1_uc001mlg.2_Intron|COPB1_uc001mlh.2_Intron	NM_016451	NP_057535			coatomer protein complex, subunit beta 1						COPI coating of Golgi vesicle|interspecies interaction between organisms|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|ER-Golgi intermediate compartment|plasma membrane	protein binding|structural molecule activity			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
PDE3B	5140	broad.mit.edu	37	11	14807885	14807886	+	Intron	DEL	AT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:14807885_14807886delAT	uc001mln.2	+						PDE3B_uc010rcr.1_Intron	NM_000922	NP_000913			phosphodiesterase 3B						cAMP catabolic process|insulin receptor signaling pathway|negative regulation of lipid catabolic process|platelet activation	cytosol|endoplasmic reticulum|Golgi apparatus|guanyl-nucleotide exchange factor complex|integral to membrane|microsome	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding|protein kinase B binding				0																		---	---	---	---
ABCC8	6833	broad.mit.edu	37	11	17452095	17452096	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:17452095_17452096delTT	uc001mnc.2	-							NM_000352	NP_000343			ATP-binding cassette, sub-family C, member 8						carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)													---	---	---	---
SAA4	6291	broad.mit.edu	37	11	18257512	18257512	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:18257512delA	uc001mny.2	-							NM_006512	NP_006503			serum amyloid A4, constitutive precursor						acute-phase response	high-density lipoprotein particle					0																		---	---	---	---
TSG101	7251	broad.mit.edu	37	11	18530965	18530965	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:18530965delA	uc001mor.2	-						TSG101_uc001mos.1_Intron|TSG101_uc009yhs.1_Intron	NM_006292	NP_006283			tumor susceptibility gene 101						cell division|cellular membrane organization|endosome transport|interspecies interaction between organisms|non-lytic virus budding|protein transport|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	early endosome|late endosome membrane|multivesicular body|nucleolus|plasma membrane	calcium-dependent protein binding|DNA binding|transcription corepressor activity|ubiquitin binding|ubiquitin protein ligase binding				0																		---	---	---	---
PTPN5	84867	broad.mit.edu	37	11	18771070	18771070	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:18771070delG	uc001mpd.2	-						PTPN5_uc001mpb.2_Intron|PTPN5_uc001mpc.2_Intron|PTPN5_uc001mpe.2_Intron|PTPN5_uc010rdj.1_Intron|PTPN5_uc001mpf.2_Intron|PTPN5_uc010rdk.1_Intron	NM_006906	NP_008837			protein-tyrosine-phosphatase non-receptor 5							integral to membrane	phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(2)	2																		---	---	---	---
CSRP3	8048	broad.mit.edu	37	11	19204344	19204344	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:19204344delT	uc001mpk.2	-							NM_003476	NP_003467			cysteine and glycine-rich protein 3						cell differentiation|skeletal muscle tissue development	cytoskeleton|nucleus	protein binding|zinc ion binding				0																		---	---	---	---
CSRP3	8048	broad.mit.edu	37	11	19214121	19214121	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:19214121delT	uc001mpk.2	-							NM_003476	NP_003467			cysteine and glycine-rich protein 3						cell differentiation|skeletal muscle tissue development	cytoskeleton|nucleus	protein binding|zinc ion binding				0																		---	---	---	---
LGR4	55366	broad.mit.edu	37	11	27390693	27390693	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:27390693delA	uc001mrj.3	-						LGR4_uc001mrk.3_Intron	NM_018490	NP_060960			leucine-rich repeat-containing G protein-coupled							integral to membrane|plasma membrane	protein-hormone receptor activity			ovary(1)	1																		---	---	---	---
KIF18A	81930	broad.mit.edu	37	11	28057728	28057728	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:28057728delA	uc001msc.2	-							NM_031217	NP_112494			kinesin family member 18A						blood coagulation|microtubule depolymerization|microtubule-based movement|mitotic metaphase plate congression|mitotic prometaphase|protein transport	caveola|cytosol|kinetochore microtubule|microtubule organizing center|nucleus|ruffle	actin binding|ATP binding|microtubule plus-end binding|plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity|ubiquitin binding			ovary(2)	2																		---	---	---	---
KIF18A	81930	broad.mit.edu	37	11	28058226	28058226	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:28058226delA	uc001msc.2	-							NM_031217	NP_112494			kinesin family member 18A						blood coagulation|microtubule depolymerization|microtubule-based movement|mitotic metaphase plate congression|mitotic prometaphase|protein transport	caveola|cytosol|kinetochore microtubule|microtubule organizing center|nucleus|ruffle	actin binding|ATP binding|microtubule plus-end binding|plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity|ubiquitin binding			ovary(2)	2																		---	---	---	---
MPPED2	744	broad.mit.edu	37	11	30602049	30602049	+	5'Flank	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:30602049delA	uc001msr.2	-						MPPED2_uc001msq.3_Intron|MPPED2_uc009yji.2_Intron	NM_001584	NP_001575			metallophosphoesterase domain containing 2						nervous system development		hydrolase activity|metal ion binding			skin(1)	1																		---	---	---	---
DCDC1	341019	broad.mit.edu	37	11	31287157	31287157	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:31287157delA	uc001msv.2	-						DCDC1_uc001msu.1_Intron	NM_181807	NP_861523			doublecortin domain containing 1						intracellular signal transduction					skin(1)	1	Lung SC(675;0.225)																	---	---	---	---
PAX6	5080	broad.mit.edu	37	11	31812317	31812317	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:31812317delG	uc001mtd.3	-	11	2014	c.1124delC	c.(1123-1125)CCAfs	p.P375fs	PAX6_uc001mte.3_Frame_Shift_Del_p.P375fs|PAX6_uc001mtg.3_Frame_Shift_Del_p.P389fs|PAX6_uc001mtf.3_Frame_Shift_Del_p.P375fs|PAX6_uc001mth.3_Frame_Shift_Del_p.P375fs|PAX6_uc009yjr.2_Frame_Shift_Del_p.P375fs	NM_001127612	NP_001121084	P26367	PAX6_HUMAN	paired box gene 6 isoform a	375	Pro/Ser/Thr-rich.		P -> Q (in AN; reduced DNA binding ability).		blood vessel development|central nervous system development|cornea development in camera-type eye|glucose homeostasis|iris morphogenesis|negative regulation of neurogenesis|neuron fate commitment|pancreatic A cell development|positive regulation of transcription, DNA-dependent|response to wounding|visual perception	cytoplasm|nuclear chromatin	R-SMAD binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|ubiquitin-protein ligase activity			lung(4)|ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	9	Lung SC(675;0.225)													Wilms_tumor-Aniridia-ambiguous_Genitals-mental_Retardation				---	---	---	---
PRRG4	79056	broad.mit.edu	37	11	32860418	32860418	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:32860418delT	uc001mtx.2	+							NM_024081	NP_076986			proline rich Gla (G-carboxyglutamic acid) 4							extracellular region|Golgi apparatus|integral to membrane	calcium ion binding				0	Breast(20;0.206)																	---	---	---	---
TCP11L1	55346	broad.mit.edu	37	11	33080665	33080665	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:33080665delT	uc001mud.2	+						TCP11L1_uc009yju.2_Intron|TCP11L1_uc010rei.1_Intron|TCP11L1_uc001mue.2_Intron|TCP11L1_uc001muf.1_Intron	NM_018393	NP_060863			t-complex 11 (mouse) like 1												0																		---	---	---	---
NAT10	55226	broad.mit.edu	37	11	34152854	34152854	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:34152854delT	uc001mvk.2	+						NAT10_uc010ren.1_Intron	NM_024662	NP_078938			N-acetyltransferase 10 isoform a							nucleolus	ATP binding|N-acetyltransferase activity|protein binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(5;0.0119)|all_hematologic(20;0.0231)																---	---	---	---
NAT10	55226	broad.mit.edu	37	11	34153221	34153221	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:34153221delT	uc001mvk.2	+						NAT10_uc010ren.1_Intron	NM_024662	NP_078938			N-acetyltransferase 10 isoform a							nucleolus	ATP binding|N-acetyltransferase activity|protein binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(5;0.0119)|all_hematologic(20;0.0231)																---	---	---	---
CAT	847	broad.mit.edu	37	11	34483083	34483083	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:34483083delT	uc001mvm.2	+						CAT_uc009ykc.1_Intron|CAT_uc001mvn.2_Intron	NM_001752	NP_001743			catalase						hydrogen peroxide catabolic process|negative regulation of apoptosis|positive regulation of cell division|protein tetramerization|purine base metabolic process|purine nucleotide catabolic process|UV protection	peroxisomal matrix|peroxisomal membrane	catalase activity|heme binding|NADP binding|protein homodimerization activity			ovary(2)|pancreas(1)	3		Lung NSC(402;2.76e-08)|Acute lymphoblastic leukemia(5;0.00143)|all_hematologic(20;0.0116)|Melanoma(852;0.027)		BRCA - Breast invasive adenocarcinoma(625;0.000995)	Fomepizole(DB01213)													---	---	---	---
ACCSL	390110	broad.mit.edu	37	11	44077578	44077580	+	Intron	DEL	CTT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:44077578_44077580delCTT	uc001mxw.1	+						ACCSL_uc009ykr.2_Intron	NM_001031854	NP_001027025			1-aminocyclopropane-1-carboxylate synthase								1-aminocyclopropane-1-carboxylate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(5)	5																		---	---	---	---
CKAP5	9793	broad.mit.edu	37	11	46792292	46792292	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:46792292delT	uc001ndi.1	-						CKAP5_uc009ylg.1_Intron|CKAP5_uc001ndj.1_Intron|CKAP5_uc001ndh.1_5'Flank	NM_001008938	NP_001008938			colonic and hepatic tumor over-expressed protein						cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2																		---	---	---	---
C11orf49	79096	broad.mit.edu	37	11	47179233	47179233	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:47179233delC	uc001ndp.2	+						C11orf49_uc001nds.2_Intron|C11orf49_uc001ndq.2_Intron|C11orf49_uc001ndr.2_Intron|C11orf49_uc010rgx.1_Intron|C11orf49_uc010rgy.1_Intron|C11orf49_uc010rgz.1_Intron	NM_024113	NP_077018			hypothetical protein LOC79096 isoform 3												0																		---	---	---	---
MTCH2	23788	broad.mit.edu	37	11	47657242	47657242	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:47657242delT	uc010rho.1	-						MTCH2_uc001nge.2_Intron|MTCH2_uc010rhp.1_Intron	NM_014342	NP_055157			mitochondrial carrier 2						transport	integral to membrane|mitochondrial inner membrane					0																		---	---	---	---
AGBL2	79841	broad.mit.edu	37	11	47713524	47713524	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:47713524delT	uc001ngg.2	-						AGBL2_uc001ngf.2_5'Flank|AGBL2_uc010rhq.1_Intron|AGBL2_uc001ngh.1_Intron	NM_024783	NP_079059			carboxypeptidase 2, cytosolic						proteolysis	cytosol	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2																		---	---	---	---
NUP160	23279	broad.mit.edu	37	11	47843813	47843815	+	Intron	DEL	ATT	-	-	rs76943871		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:47843813_47843815delATT	uc001ngm.2	-						NUP160_uc009ylw.2_Intron	NM_015231	NP_056046			nucleoporin 160kDa						carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7																		---	---	---	---
Unknown	0	broad.mit.edu	37	11	48967951	48967951	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:48967951delA								OR4A47 (456679 upstream) : FOLH1 (200237 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	11	49896454	49896454	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:49896454delT								LOC440040 (64487 upstream) : OR4C13 (77521 downstream)																																			---	---	---	---
TRIM48	79097	broad.mit.edu	37	11	55035952	55035952	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55035952delT	uc010rid.1	+							NM_024114	NP_077019			tripartite motif-containing 48							intracellular	zinc ion binding				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	11	55179009	55179009	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55179009delA								OR4A15 (42616 upstream) : OR4C15 (142774 downstream)																																			---	---	---	---
OR5W2	390148	broad.mit.edu	37	11	55682137	55682137	+	5'Flank	DEL	A	-	-	rs79964529		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55682137delA	uc010rir.1	-							NM_001001960	NP_001001960			olfactory receptor, family 5, subfamily W,						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2																		---	---	---	---
OR5M3	219482	broad.mit.edu	37	11	56237709	56237709	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:56237709delT	uc010rjk.1	-	1	265	c.265delA	c.(265-267)ACAfs	p.T89fs		NM_001004742	NP_001004742	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M,	89	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)																	---	---	---	---
CLP1	10978	broad.mit.edu	37	11	57428126	57428126	+	Intron	DEL	A	-	-	rs74496835		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:57428126delA	uc001nkw.2	+						CLP1_uc010rjw.1_Intron|CLP1_uc009yml.2_Intron	NM_006831	NP_006822			ATP/GTP-binding protein isoform 1						mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|siRNA loading onto RISC involved in RNA interference|targeting of mRNA for destruction involved in RNA interference|termination of RNA polymerase II transcription|tRNA splicing, via endonucleolytic cleavage and ligation	nucleoplasm|tRNA-intron endonuclease complex	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity			ovary(1)	1																		---	---	---	---
CTNND1	1500	broad.mit.edu	37	11	57563859	57563859	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:57563859delA	uc001nmc.3	+						CTNND1_uc001nlf.1_Intron|CTNND1_uc001nlh.1_Intron|CTNND1_uc001nlu.3_Intron|CTNND1_uc001nlt.3_Intron|CTNND1_uc001nls.3_Intron|CTNND1_uc001nlw.3_Intron|CTNND1_uc001nmf.3_Intron|CTNND1_uc001nmd.3_Intron|CTNND1_uc001nlk.3_Intron|CTNND1_uc001nme.3_Intron|CTNND1_uc001nll.3_Intron|CTNND1_uc001nmg.3_Intron|CTNND1_uc001nlj.3_Intron|CTNND1_uc001nlr.3_Intron|CTNND1_uc001nlp.3_Intron|CTNND1_uc001nlx.3_Intron|CTNND1_uc001nlz.3_Intron|CTNND1_uc009ymn.2_Intron|CTNND1_uc001nlm.3_Intron|CTNND1_uc001nly.3_Intron|CTNND1_uc001nmb.3_Intron|CTNND1_uc001nma.3_Intron|CTNND1_uc001nmi.3_Intron|CTNND1_uc001nmh.3_Intron|CTNND1_uc001nlq.3_Intron|CTNND1_uc001nln.3_Intron|CTNND1_uc001nli.3_Intron|CTNND1_uc001nlo.3_Intron|CTNND1_uc001nlv.3_Intron	NM_001085458	NP_001078927			catenin, delta 1 isoform 1ABC						adherens junction organization|cell junction assembly|negative regulation of canonical Wnt receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytosol|midbody|nucleus	cadherin binding|protein binding|receptor binding			breast(4)|ovary(1)|kidney(1)	6		all_epithelial(135;0.155)																---	---	---	---
OR5B3	441608	broad.mit.edu	37	11	58170465	58170466	+	Frame_Shift_Del	DEL	CA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:58170465_58170466delCA	uc010rkf.1	-	1	417_418	c.417_418delTG	c.(415-420)TGTGCTfs	p.C139fs		NM_001005469	NP_001005469	Q8NH48	OR5B3_HUMAN	olfactory receptor, family 5, subfamily B,	139_140	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(5;0.0027)	Breast(21;0.0778)																---	---	---	---
GLYAT	10249	broad.mit.edu	37	11	58482936	58482936	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:58482936delA	uc001nnb.2	-						GLYAT_uc001nnc.2_Intron	NM_201648	NP_964011			glycine-N-acyltransferase isoform a						acyl-CoA metabolic process|response to toxin|xenobiotic metabolic process	mitochondrial matrix	glycine N-acyltransferase activity|glycine N-benzoyltransferase activity				0		Breast(21;0.0044)|all_epithelial(135;0.0157)			Glycine(DB00145)													---	---	---	---
MS4A14	84689	broad.mit.edu	37	11	60182852	60182852	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:60182852delA	uc001npj.2	+						MS4A14_uc001npi.2_Intron|MS4A14_uc001npn.2_Intron|MS4A14_uc001npk.2_Intron|MS4A14_uc001npl.2_Intron|MS4A14_uc001npm.2_Intron	NM_032597	NP_115986			membrane-spanning 4-domains, subfamily A, member							integral to membrane	receptor activity			breast(1)	1																		---	---	---	---
MS4A1	931	broad.mit.edu	37	11	60234644	60234644	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:60234644delA	uc001npp.2	+						MS4A1_uc001npq.2_Intron|MS4A1_uc009yna.2_Intron|MS4A1_uc009ymz.2_Intron|MS4A1_uc010rlc.1_Intron	NM_152866	NP_690605			membrane-spanning 4-domains, subfamily A, member						B cell activation|immune response	integral to plasma membrane				ovary(3)|lung(2)	5					Ibritumomab(DB00078)|Rituximab(DB00073)|Tositumomab(DB00081)													---	---	---	---
TMEM132A	54972	broad.mit.edu	37	11	60696555	60696559	+	Intron	DEL	AAACT	-	-	rs139814160		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:60696555_60696559delAAACT	uc001nqj.2	+						TMEM132A_uc001nqi.2_Intron|TMEM132A_uc001nqk.2_Intron|TMEM132A_uc001nql.1_Intron	NM_178031	NP_821174			transmembrane protein 132A isoform b							endoplasmic reticulum membrane|Golgi membrane|integral to membrane				skin(1)	1																		---	---	---	---
TMEM216	51259	broad.mit.edu	37	11	61161279	61161280	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:61161279_61161280insT	uc010rlj.1	+						TMEM216_uc001nrn.1_Intron	NM_016499	NP_057583			transmembrane protein 216							integral to membrane					0																		---	---	---	---
CPSF7	79869	broad.mit.edu	37	11	61184129	61184130	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:61184129_61184130insT	uc001nrq.2	-						CPSF7_uc001nro.2_Intron|CPSF7_uc001nrp.2_Intron|CPSF7_uc001nrr.2_Intron|CPSF7_uc001nrs.1_Intron	NM_001136040	NP_001129512			pre-mRNA cleavage factor I, 59 kDa subunit						mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|protein tetramerization|termination of RNA polymerase II transcription	mRNA cleavage factor complex	nucleotide binding|protein binding|RNA binding			central_nervous_system(1)	1																		---	---	---	---
TUT1	64852	broad.mit.edu	37	11	62346016	62346016	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62346016delA	uc001nto.2	-						TUT1_uc001ntp.1_5'Flank	NM_022830	NP_073741			terminal uridylyl transferase 1, U6						mRNA cleavage|mRNA polyadenylation|snRNA processing	nuclear speck|nucleolus	ATP binding|enzyme binding|mRNA 3'-UTR binding|polynucleotide adenylyltransferase activity|RNA uridylyltransferase activity|zinc ion binding			central_nervous_system(1)|skin(1)	2																		---	---	---	---
INTS5	80789	broad.mit.edu	37	11	62417596	62417596	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62417596delT	uc001nud.2	-							NM_030628	NP_085131			integrator complex subunit 5						snRNA processing	integral to membrane|integrator complex	protein binding			ovary(2)	2																		---	---	---	---
NXF1	10482	broad.mit.edu	37	11	62561638	62561638	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62561638delA	uc001nvf.1	-						TMEM223_uc001nve.2_5'Flank|NXF1_uc001nvg.1_Intron	NM_006362	NP_006353			nuclear RNA export factor 1 isoform 1						gene expression|interspecies interaction between organisms	cytosol|nuclear speck	nucleotide binding|protein binding			skin(3)	3																		---	---	---	---
GPR137	56834	broad.mit.edu	37	11	64055217	64055217	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:64055217delG	uc001nzg.1	+	4	740	c.432delG	c.(430-432)GTGfs	p.V144fs	GPR137_uc009ypj.1_Frame_Shift_Del_p.V150fs|GPR137_uc010rni.1_Frame_Shift_Del_p.V202fs|GPR137_uc001nze.1_Frame_Shift_Del_p.V144fs|GPR137_uc001nzf.2_Frame_Shift_Del_p.V144fs|GPR137_uc001nzh.1_Frame_Shift_Del_p.V144fs|GPR137_uc001nzi.2_Frame_Shift_Del_p.V144fs|GPR137_uc010rnj.1_Frame_Shift_Del_p.V144fs	NM_020155	NP_064540	Q96N19	G137A_HUMAN	G protein-coupled receptor 137	144	Helical; (Potential).					integral to membrane				central_nervous_system(1)	1																		---	---	---	---
CCDC88B	283234	broad.mit.edu	37	11	64121543	64121543	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:64121543delG	uc001nzy.2	+	24	4044	c.4000delG	c.(4000-4002)GGGfs	p.G1334fs	CCDC88B_uc009ypo.1_Frame_Shift_Del_p.G1331fs|CCDC88B_uc001oaa.2_Intron|CCDC88B_uc001oab.1_Frame_Shift_Del_p.G165fs|CCDC88B_uc001oac.2_Intron	NM_032251	NP_115627	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88	1334					microtubule cytoskeleton organization	cytoplasm	microtubule binding			ovary(3)|skin(1)	4																		---	---	---	---
NRXN2	9379	broad.mit.edu	37	11	64374527	64374527	+	3'UTR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:64374527delT	uc001oap.2	-	8					NRXN2_uc001oar.2_3'UTR|NRXN2_uc001oas.2_3'UTR|NRXN2_uc001oao.2_3'UTR|NRXN2_uc001oaq.2_3'UTR	NM_138734	NP_620063			neurexin 2 isoform beta precursor						cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10																		---	---	---	---
SNX15	29907	broad.mit.edu	37	11	64802769	64802770	+	Intron	DEL	TG	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:64802769_64802770delTG	uc001oci.3	+						SNX15_uc009ypy.2_Intron|SNX15_uc001ocj.2_Intron|SNX15_uc001ock.2_Intron	NM_013306	NP_037438			sorting nexin 15 isoform A						cell communication|intracellular protein transport	cytoplasmic vesicle membrane|cytosol	phosphatidylinositol binding|protein transporter activity			ovary(1)	1																		---	---	---	---
MAP3K11	4296	broad.mit.edu	37	11	65376091	65376091	+	Intron	DEL	T	-	-	rs112101273		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65376091delT	uc001oew.2	-						MAP3K11_uc001oev.2_5'Flank|MAP3K11_uc010rol.1_Intron|MAP3K11_uc001oex.1_5'Flank	NM_002419	NP_002410			mitogen-activated protein kinase kinase kinase						activation of JUN kinase activity|cell proliferation|G1 phase of mitotic cell cycle|microtubule-based process|positive regulation of JNK cascade|protein autophosphorylation	centrosome|microtubule	ATP binding|JUN kinase kinase kinase activity|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity			breast(3)|lung(1)|central_nervous_system(1)|skin(1)	6																		---	---	---	---
NPAS4	266743	broad.mit.edu	37	11	66190092	66190093	+	Intron	INS	-	TC	TC			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66190092_66190093insTC	uc001ohx.1	+						NPAS4_uc010rpc.1_Intron	NM_178864	NP_849195			neuronal PAS domain protein 4						transcription, DNA-dependent		DNA binding|signal transducer activity				0																		---	---	---	---
KDM2A	22992	broad.mit.edu	37	11	66983146	66983147	+	Intron	DEL	AA	-	-	rs113780245	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66983146_66983147delAA	uc001ojw.2	+						KDM2A_uc001ojx.2_Intron|KDM2A_uc001ojy.2_Intron	NM_012308	NP_036440			F-box and leucine-rich repeat protein 11						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			ovary(4)|lung(3)|breast(1)|skin(1)	9																		---	---	---	---
CORO1B	57175	broad.mit.edu	37	11	67209168	67209168	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:67209168delG	uc001olj.1	-						CORO1B_uc009yrs.1_Intron|CORO1B_uc001olk.1_Intron|CORO1B_uc009yrt.1_Intron|CORO1B_uc009yru.1_Intron|CORO1B_uc001oll.1_Intron|CORO1B_uc010rps.1_Intron|CORO1B_uc009yrv.1_Frame_Shift_Del_p.H164fs	NM_020441	NP_065174			coronin, actin binding protein, 1B						actin cytoskeleton organization	actin cytoskeleton|cytoplasm	actin filament binding			large_intestine(1)|ovary(1)	2			BRCA - Breast invasive adenocarcinoma(15;3.26e-06)															---	---	---	---
NDUFV1	4723	broad.mit.edu	37	11	67378705	67378705	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:67378705delG	uc001omj.2	+						NDUFV1_uc010rpv.1_Intron|NDUFV1_uc001oml.2_Intron|NDUFV1_uc001omk.3_Intron|NDUFV1_uc009yrz.1_Intron|NDUFV1_uc010rpw.1_Intron	NM_007103	NP_009034			NADH dehydrogenase ubiquinone flavoprotein 1						mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|FMN binding|metal ion binding|NAD binding|NADH dehydrogenase (ubiquinone) activity			skin(1)	1					NADH(DB00157)													---	---	---	---
TPCN2	219931	broad.mit.edu	37	11	68834894	68834895	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:68834894_68834895insT	uc001oos.2	+						TPCN2_uc009ysk.1_Intron|TPCN2_uc001oor.2_Intron|TPCN2_uc010rqg.1_Intron	NM_139075	NP_620714			two pore segment channel 2						cellular calcium ion homeostasis|smooth muscle contraction	endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated calcium channel activity				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)															---	---	---	---
NADSYN1	55191	broad.mit.edu	37	11	71192975	71192975	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:71192975delT	uc001oqn.2	+	13	1180	c.1054delT	c.(1054-1056)TTTfs	p.F352fs	NADSYN1_uc001oqo.2_Frame_Shift_Del_p.F92fs|NADSYN1_uc001oqp.2_5'UTR	NM_018161	NP_060631	Q6IA69	NADE_HUMAN	NAD synthetase 1	352	Ligase (By similarity).				NAD biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|NAD+ synthase (glutamine-hydrolyzing) activity|protein binding			ovary(2)	2					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)													---	---	---	---
RNF121	55298	broad.mit.edu	37	11	71694044	71694045	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:71694044_71694045insA	uc001ora.2	+						RNF121_uc001ord.2_Intron|RNF121_uc001orb.2_Intron|RNF121_uc009yst.2_Intron	NM_018320	NP_060790			ring finger protein 121							integral to membrane	zinc ion binding				0																		---	---	---	---
NUMA1	4926	broad.mit.edu	37	11	71728560	71728561	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:71728560_71728561delAA	uc001orl.1	-						NUMA1_uc009ysw.1_5'Flank|NUMA1_uc001ork.1_Intron|NUMA1_uc001orm.1_Intron|NUMA1_uc001orn.2_5'Flank|NUMA1_uc009ysx.1_Intron|NUMA1_uc001oro.1_Intron|NUMA1_uc009ysy.1_3'UTR|NUMA1_uc001orp.2_3'UTR|NUMA1_uc001orq.2_3'UTR	NM_006185	NP_006176			nuclear mitotic apparatus protein 1						G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			ovary(3)|lung(2)|skin(2)|central_nervous_system(1)	8								T	RARA	APL								---	---	---	---
PDE2A	5138	broad.mit.edu	37	11	72292040	72292040	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:72292040delA	uc010rrc.1	-						PDE2A_uc001oso.2_Intron|PDE2A_uc010rra.1_Intron|PDE2A_uc001osn.2_Intron|PDE2A_uc010rrb.1_Intron|PDE2A_uc010rrd.1_Intron	NM_002599	NP_002590			phosphodiesterase 2A isoform 1						platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(2)|breast(1)|skin(1)	4			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)													---	---	---	---
C11orf30	56946	broad.mit.edu	37	11	76255914	76255914	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:76255914delA	uc001oxl.2	+						C11orf30_uc001oxm.2_Intron|C11orf30_uc010rsb.1_Intron|C11orf30_uc010rsc.1_Intron|C11orf30_uc001oxn.2_Intron|C11orf30_uc010rsd.1_Intron|C11orf30_uc010rse.1_Intron|C11orf30_uc001oxp.2_Intron	NM_020193	NP_064578			EMSY protein						chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6																		---	---	---	---
ACER3	55331	broad.mit.edu	37	11	76709664	76709664	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:76709664delT	uc009yum.1	+						ACER3_uc010rsg.1_Intron|ACER3_uc009yul.1_Intron|ACER3_uc001oxu.2_Intron|ACER3_uc009yun.1_Intron|ACER3_uc009yuo.1_Intron|ACER3_uc010rsh.1_Intron|ACER3_uc010rsi.1_Intron|ACER3_uc010rsj.1_Intron	NM_018367	NP_060837			phytoceramidase, alkaline						ceramide metabolic process|phytosphingosine biosynthetic process|positive regulation of cell proliferation|sphingosine biosynthetic process	integral to endoplasmic reticulum membrane|integral to Golgi membrane	phytoceramidase activity				0																		---	---	---	---
CLNS1A	1207	broad.mit.edu	37	11	77336676	77336679	+	Intron	DEL	GTGT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:77336676_77336679delGTGT	uc001oyk.2	-						CLNS1A_uc001oyl.2_Intron	NM_001293	NP_001284			chloride channel, nucleotide-sensitive, 1A						blood circulation|cell volume homeostasis|chloride transport|ncRNA metabolic process|spliceosomal snRNP assembly	cytoskeleton|cytosol|nucleus|plasma membrane	protein binding			ovary(1)	1	all_cancers(14;5.43e-17)|all_epithelial(13;1.78e-19)		Epithelial(5;1.02e-48)|BRCA - Breast invasive adenocarcinoma(5;1.4e-30)															---	---	---	---
RSF1	51773	broad.mit.edu	37	11	77409751	77409751	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:77409751delA	uc001oyn.2	-						RSF1_uc001oym.2_Intron	NM_016578	NP_057662			remodeling and spacing factor 1						CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)															---	---	---	---
RSF1	51773	broad.mit.edu	37	11	77413116	77413116	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:77413116delT	uc001oyn.2	-	6	1278	c.1158delA	c.(1156-1158)AAAfs	p.K386fs	RSF1_uc001oym.2_Frame_Shift_Del_p.K134fs	NM_016578	NP_057662	Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	386					CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)															---	---	---	---
NARS2	79731	broad.mit.edu	37	11	78154811	78154812	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:78154811_78154812delAA	uc001ozi.2	-						NARS2_uc010rsq.1_Intron	NM_024678	NP_078954			asparaginyl-tRNA synthetase 2, mitochondrial						asparaginyl-tRNA aminoacylation	mitochondrial matrix	asparagine-tRNA ligase activity|ATP binding|nucleic acid binding			ovary(2)	2	all_cancers(14;2.63e-17)|all_epithelial(13;1.85e-19)				L-Asparagine(DB00174)													---	---	---	---
ODZ4	26011	broad.mit.edu	37	11	78440816	78440816	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:78440816delA	uc001ozl.3	-							NM_001098816	NP_001092286			odz, odd Oz/ten-m homolog 4						signal transduction	integral to membrane				ovary(2)|pancreas(2)	4																		---	---	---	---
PRCP	5547	broad.mit.edu	37	11	82550236	82550236	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:82550236delT	uc001ozs.2	-						PRCP_uc001ozr.2_Intron	NM_005040	NP_005031			prolylcarboxypeptidase isoform 1 preproprotein						blood coagulation, intrinsic pathway|proteolysis	lysosome|plasma membrane	protein binding|serine-type carboxypeptidase activity			skin(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	11	90017337	90017337	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:90017337delA								CHORDC1 (60805 upstream) : MIR1261 (584952 downstream)																																			---	---	---	---
SLC36A4	120103	broad.mit.edu	37	11	92896062	92896062	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:92896062delT	uc001pdn.2	-						SLC36A4_uc001pdm.2_Intron	NM_152313	NP_689526			solute carrier family 36 (proton/amino acid						L-alanine transport|proline transport|tryptophan transport	integral to membrane	symporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)																---	---	---	---
SNORA8	654320	broad.mit.edu	37	11	93464783	93464783	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:93464783delT	uc001pec.2	-						TAF1D_uc001pdz.2_Intron|SNORA25_uc001pdy.3_5'Flank|SNORA32_uc009ywc.1_5'Flank|TAF1D_uc001pea.1_Intron|SNORD6_uc001peb.2_5'Flank					Homo sapiens cDNA: FLJ23363 fis, clone HEP15507.												0																		---	---	---	---
Unknown	0	broad.mit.edu	37	11	97158168	97158168	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:97158168delT								None (None upstream) : None (None downstream)																																			---	---	---	---
YAP1	10413	broad.mit.edu	37	11	102056691	102056691	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:102056691delT	uc001pgt.2	+						YAP1_uc001pgs.2_Intron|YAP1_uc001pgu.2_Intron|YAP1_uc001pgv.2_Intron|YAP1_uc010ruo.1_Intron|YAP1_uc001pgw.2_Intron|YAP1_uc010rup.1_5'Flank	NM_001130145	NP_001123617			Yes-associated protein 1, 65kDa isoform 1						cell proliferation|cellular response to gamma radiation|contact inhibition|hippo signaling cascade|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription coactivator activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(1)|lung(1)|central_nervous_system(1)	3	all_cancers(8;0.000575)|all_epithelial(12;0.00564)	Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.00936)	Lung(13;0.245)	BRCA - Breast invasive adenocarcinoma(274;0.0189)														---	---	---	---
DYNC2H1	79659	broad.mit.edu	37	11	102995711	102995712	+	Intron	INS	-	T	T	rs140570273	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:102995711_102995712insT	uc001pho.2	+						DYNC2H1_uc001phn.1_Intron|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932			dynein, cytoplasmic 2, heavy chain 1						cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)														---	---	---	---
DYNC2H1	79659	broad.mit.edu	37	11	102996096	102996102	+	Intron	DEL	TTTTTTT	-	-	rs34114270		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:102996096_102996102delTTTTTTT	uc001pho.2	+						DYNC2H1_uc001phn.1_Intron|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932			dynein, cytoplasmic 2, heavy chain 1						cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)														---	---	---	---
PDGFD	80310	broad.mit.edu	37	11	104034730	104034730	+	5'UTR	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:104034730delC	uc001phq.2	-	1					PDGFD_uc001php.2_5'UTR	NM_025208	NP_079484			platelet derived growth factor D isoform 1						positive regulation of cell division	endoplasmic reticulum lumen|extracellular region|Golgi membrane	growth factor activity			upper_aerodigestive_tract(1)|large_intestine(1)	2		Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Melanoma(852;0.0563)|all_neural(303;0.165)		BRCA - Breast invasive adenocarcinoma(274;0.00136)|Epithelial(105;0.111)												OREG0021315	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
KBTBD3	143879	broad.mit.edu	37	11	105929470	105929470	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:105929470delT	uc001pja.2	-						KBTBD3_uc001pjb.2_Intron|KBTBD3_uc009yxm.2_Intron	NM_198439	NP_940841			BTB and kelch domain containing 3											ovary(1)|central_nervous_system(1)	2		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.43e-05)|Epithelial(105;0.00418)|all cancers(92;0.0299)														---	---	---	---
CWF19L2	143884	broad.mit.edu	37	11	107312354	107312354	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:107312354delA	uc010rvp.1	-						CWF19L2_uc001pjh.3_Intron|CWF19L2_uc009yxo.2_Intron	NM_152434	NP_689647			CWF19-like 2, cell cycle control								catalytic activity				0		Melanoma(852;1.75e-05)|all_epithelial(67;6.27e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0258)		Epithelial(105;7.18e-06)|BRCA - Breast invasive adenocarcinoma(274;1.65e-05)|all cancers(92;1.76e-05)														---	---	---	---
CUL5	8065	broad.mit.edu	37	11	107920607	107920607	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:107920607delT	uc001pjv.2	+						CUL5_uc001pju.2_Intron	NM_003478	NP_003469			Vasopressin-activated calcium-mobilizing						cell cycle arrest|cell proliferation|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process|viral reproduction	cullin-RING ubiquitin ligase complex|cytosol	calcium channel activity|receptor activity|ubiquitin protein ligase binding			ovary(1)	1		all_cancers(61;7.09e-10)|all_epithelial(67;2.97e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|Melanoma(852;4.48e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;3.58e-05)|Epithelial(105;4.68e-05)|all cancers(92;0.00122)|OV - Ovarian serous cystadenocarcinoma(223;0.217)														---	---	---	---
NPAT	4863	broad.mit.edu	37	11	108047686	108047686	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:108047686delT	uc001pjz.3	-						NPAT_uc001pka.2_Intron	NM_002519	NP_002510			nuclear protein,  ataxia-telangiectasia locus						positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	protein C-terminus binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			ovary(2)	2		all_cancers(61;2.31e-10)|all_epithelial(67;1.11e-06)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;1.05e-05)|Epithelial(105;3.01e-05)|all cancers(92;0.000816)|Colorectal(284;0.116)														---	---	---	---
ATM	472	broad.mit.edu	37	11	108139043	108139043	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:108139043delT	uc001pkb.1	+						ATM_uc009yxr.1_Intron|ATM_uc009yxs.1_5'Flank	NM_000051	NP_000042			ataxia telangiectasia mutated isoform 1						cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)				D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			---	---	---	---
ATM	472	broad.mit.edu	37	11	108206006	108206006	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:108206006delT	uc001pkb.1	+						ATM_uc009yxr.1_Intron|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_RNA|ATM_uc001pke.1_Intron	NM_000051	NP_000042			ataxia telangiectasia mutated isoform 1						cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)				D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			---	---	---	---
DDX10	1662	broad.mit.edu	37	11	108548163	108548163	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:108548163delT	uc001pkm.2	+						DDX10_uc001pkl.1_Intron	NM_004398	NP_004389			DEAD (Asp-Glu-Ala-Asp) box polypeptide 10								ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity			breast(2)|lung(1)|prostate(1)	4		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)				T	NUP98	AML*								---	---	---	---
DDX10	1662	broad.mit.edu	37	11	108559530	108559530	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:108559530delT	uc001pkm.2	+						DDX10_uc001pkl.1_Intron	NM_004398	NP_004389			DEAD (Asp-Glu-Ala-Asp) box polypeptide 10								ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity			breast(2)|lung(1)|prostate(1)	4		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)				T	NUP98	AML*								---	---	---	---
DDX10	1662	broad.mit.edu	37	11	108788854	108788854	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:108788854delT	uc001pkm.2	+						DDX10_uc001pkl.1_3'UTR	NM_004398	NP_004389			DEAD (Asp-Glu-Ala-Asp) box polypeptide 10								ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity			breast(2)|lung(1)|prostate(1)	4		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)				T	NUP98	AML*								---	---	---	---
FDX1	2230	broad.mit.edu	37	11	110306545	110306545	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:110306545delT	uc001pkx.2	+							NM_004109	NP_004100			ferredoxin 1 precursor						electron transport chain|transport	mitochondrial matrix	2 iron, 2 sulfur cluster binding|electron carrier activity|iron ion binding				0		all_cancers(61;1.59e-12)|all_epithelial(67;8.38e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.01e-06)|BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|all cancers(92;5.27e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0384)|Colorectal(284;0.228)	Mitotane(DB00648)													---	---	---	---
ARHGAP20	57569	broad.mit.edu	37	11	110501197	110501197	+	Intron	DEL	T	-	-	rs35229947		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:110501197delT	uc001pkz.1	-						ARHGAP20_uc001pky.1_Intron|ARHGAP20_uc009yyb.1_Intron|ARHGAP20_uc001pla.1_Intron	NM_020809	NP_065860			Rho GTPase activating protein 20						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)|kidney(2)	5		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)														---	---	---	---
PPP2R1B	5519	broad.mit.edu	37	11	111625624	111625624	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:111625624delA	uc001plx.1	-						PPP2R1B_uc001plw.1_Intron|PPP2R1B_uc010rwi.1_Intron|PPP2R1B_uc010rwj.1_Intron|PPP2R1B_uc010rwk.1_Intron|PPP2R1B_uc010rwl.1_Intron	NM_002716	NP_002707			beta isoform of regulatory subunit A, protein								protein binding				0		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|Epithelial(105;2.36e-06)|all cancers(92;3.78e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0761)														---	---	---	---
PTS	5805	broad.mit.edu	37	11	112100752	112100752	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:112100752delA	uc001pnj.3	+						PTS_uc009yyo.2_Intron	NM_000317	NP_000308			6-pyruvoyltetrahydropterin synthase						cellular amino acid metabolic process|central nervous system development|tetrahydrobiopterin biosynthetic process	mitochondrion	6-pyruvoyltetrahydropterin synthase activity|metal ion binding				0		all_cancers(61;2.51e-14)|all_epithelial(67;1.64e-08)|Melanoma(852;8.81e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;1.27e-06)|BRCA - Breast invasive adenocarcinoma(274;1.43e-06)|all cancers(92;2.1e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0519)														---	---	---	---
Unknown	0	broad.mit.edu	37	11	112332121	112332121	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:112332121delT								PTS (191444 upstream) : NCAM1 (499874 downstream)																																			---	---	---	---
TTC12	54970	broad.mit.edu	37	11	113194320	113194320	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:113194320delT	uc001pnu.2	+						TTC12_uc001pnv.2_Intron|TTC12_uc001pnw.2_Intron|TTC12_uc001pnx.2_Intron	NM_017868	NP_060338			tetratricopeptide repeat domain 12								binding			pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4		all_cancers(61;2.73e-16)|all_epithelial(67;8.64e-10)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.183)|Renal(330;0.187)		BRCA - Breast invasive adenocarcinoma(274;5.3e-06)|Epithelial(105;8.37e-05)|all cancers(92;0.000694)														---	---	---	---
Unknown	0	broad.mit.edu	37	11	114383758	114383759	+	IGR	INS	-	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:114383758_114383759insC								REXO2 (62760 upstream) : FAM55A (8679 downstream)																																			---	---	---	---
BUD13	84811	broad.mit.edu	37	11	116628023	116628023	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:116628023delT	uc001ppn.2	-						BUD13_uc001ppo.2_Intron	NM_032725	NP_116114			BUD13 homolog isoform 1											large_intestine(1)|pancreas(1)	2	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)														---	---	---	---
CEP164	22897	broad.mit.edu	37	11	117265007	117265008	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:117265007_117265008insT	uc001prc.2	+						CEP164_uc001prb.2_Intron|CEP164_uc010rxk.1_Intron|CEP164_uc001prf.2_Intron|CEP164_uc009yzp.1_Intron|CEP164_uc001prg.1_Intron	NM_014956	NP_055771			centrosomal protein 164kDa						cell division|DNA repair|G2/M transition of mitotic cell cycle|mitosis	centriole|cytosol|nucleus				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;4e-05)|Epithelial(105;0.0008)														---	---	---	---
FXYD6	53826	broad.mit.edu	37	11	117711831	117711831	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:117711831delC	uc001pro.1	-						FXYD6_uc001prn.1_Intron|FXYD6_uc001prp.1_Intron|FXYD6_uc001prq.1_Intron|FXYD6_uc001prr.1_Intron|FXYD6_uc009yzq.1_Intron	NM_022003	NP_071286			FXYD domain-containing ion transport regulator 6							integral to membrane|plasma membrane	ion channel activity			central_nervous_system(1)|skin(1)	2	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|Breast(348;0.111)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.89e-05)|Epithelial(105;0.00122)														---	---	---	---
UBE4A	9354	broad.mit.edu	37	11	118246074	118246074	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118246074delT	uc001psw.2	+						UBE4A_uc001psv.2_Intron	NM_004788	NP_004779			ubiquitination factor E4A						ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	5	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)														---	---	---	---
DDX6	1656	broad.mit.edu	37	11	118626216	118626217	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118626216_118626217delAA	uc001pub.2	-						DDX6_uc001pua.2_Intron|DDX6_uc001puc.2_Intron	NM_004397	NP_004388			DEAD (Asp-Glu-Ala-Asp) box polypeptide 6						exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|RNA-induced silencing complex|stress granule	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|RNA helicase activity			ovary(1)	1	all_hematologic(175;0.0839)	Renal(330;0.0183)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)|Hepatocellular(160;0.0893)|Breast(348;0.0979)|all_hematologic(192;0.103)		OV - Ovarian serous cystadenocarcinoma(223;3.39e-06)|BRCA - Breast invasive adenocarcinoma(274;3.4e-05)|Colorectal(284;0.0377)				T	IGH@	B-NHL								---	---	---	---
DDX6	1656	broad.mit.edu	37	11	118628030	118628030	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118628030delA	uc001pub.2	-						DDX6_uc001pua.2_Intron|DDX6_uc001puc.2_Intron	NM_004397	NP_004388			DEAD (Asp-Glu-Ala-Asp) box polypeptide 6						exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|RNA-induced silencing complex|stress granule	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|RNA helicase activity			ovary(1)	1	all_hematologic(175;0.0839)	Renal(330;0.0183)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)|Hepatocellular(160;0.0893)|Breast(348;0.0979)|all_hematologic(192;0.103)		OV - Ovarian serous cystadenocarcinoma(223;3.39e-06)|BRCA - Breast invasive adenocarcinoma(274;3.4e-05)|Colorectal(284;0.0377)				T	IGH@	B-NHL								---	---	---	---
DDX6	1656	broad.mit.edu	37	11	118629513	118629513	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118629513delT	uc001pub.2	-	9	1324	c.963delA	c.(961-963)AAAfs	p.K321fs	DDX6_uc001pua.2_Frame_Shift_Del_p.K21fs|DDX6_uc001puc.2_Frame_Shift_Del_p.K321fs	NM_004397	NP_004388	P26196	DDX6_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 6	321	Helicase C-terminal.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|RNA-induced silencing complex|stress granule	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|RNA helicase activity			ovary(1)	1	all_hematologic(175;0.0839)	Renal(330;0.0183)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)|Hepatocellular(160;0.0893)|Breast(348;0.0979)|all_hematologic(192;0.103)		OV - Ovarian serous cystadenocarcinoma(223;3.39e-06)|BRCA - Breast invasive adenocarcinoma(274;3.4e-05)|Colorectal(284;0.0377)				T	IGH@	B-NHL								---	---	---	---
CCDC84	338657	broad.mit.edu	37	11	118873663	118873663	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118873663delT	uc001pul.2	+						CCDC84_uc010ryk.1_Intron|CCDC84_uc010ryl.1_Intron|CCDC84_uc010rym.1_Intron	NM_198489	NP_940891			coiled-coil domain containing 84											ovary(1)	1	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_neural(223;0.224)|all_hematologic(192;0.243)		BRCA - Breast invasive adenocarcinoma(274;7.72e-05)														---	---	---	---
CBL	867	broad.mit.edu	37	11	119169036	119169038	+	Intron	DEL	AGA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:119169036_119169038delAGA	uc001pwe.2	+							NM_005188	NP_005179			Cas-Br-M (murine) ecotropic retroviral						epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of receptor-mediated endocytosis	cytosol|nucleus	calcium ion binding|sequence-specific DNA binding transcription factor activity|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(135)|lung(10)|central_nervous_system(2)|ovary(1)|breast(1)	149		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.92e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.000784)										CBL_gene-associated_Juvenile_Myelomonocytic_Leukemia_and_Developmental_Anomalies|Noonan_syndrome				---	---	---	---
ARHGEF12	23365	broad.mit.edu	37	11	120318572	120318572	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:120318572delT	uc001pxl.1	+						ARHGEF12_uc009zat.2_Intron|ARHGEF12_uc010rzn.1_Intron|ARHGEF12_uc009zau.1_Intron	NM_015313	NP_056128			Rho guanine nucleotide exchange factor (GEF) 12						apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(2)|breast(2)|skin(2)|ovary(1)	7		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)				T	MLL	AML								---	---	---	---
ARHGEF12	23365	broad.mit.edu	37	11	120340100	120340100	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:120340100delA	uc001pxl.1	+						ARHGEF12_uc009zat.2_Intron|ARHGEF12_uc010rzn.1_Intron|ARHGEF12_uc009zau.1_Intron	NM_015313	NP_056128			Rho guanine nucleotide exchange factor (GEF) 12						apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(2)|breast(2)|skin(2)|ovary(1)	7		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)				T	MLL	AML								---	---	---	---
Unknown	0	broad.mit.edu	37	11	121859323	121859324	+	IGR	DEL	AG	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:121859323_121859324delAG								SORL1 (354852 upstream) : LOC399959 (100487 downstream)																																			---	---	---	---
C11orf63	79864	broad.mit.edu	37	11	122775729	122775729	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:122775729delT	uc001pym.2	+						C11orf63_uc001pyl.1_Intron	NM_024806	NP_079082			hypothetical protein LOC79864 isoform 1											ovary(3)	3		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)														---	---	---	---
Unknown	0	broad.mit.edu	37	11	123676067	123676067	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:123676067delA								OR6X1 (50841 upstream) : OR6M1 (50 downstream)																																			---	---	---	---
VWA5A	4013	broad.mit.edu	37	11	124012217	124012217	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:124012217delG	uc001pzu.2	+						VWA5A_uc001pzt.2_Intron	NM_001130142	NP_001123614			BCSC-1 isoform 1											upper_aerodigestive_tract(1)|ovary(1)	2																		---	---	---	---
FEZ1	9638	broad.mit.edu	37	11	125333222	125333222	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:125333222delA	uc001qbx.2	-						FEZ1_uc010sbc.1_Intron	NM_005103	NP_005094			zygin 1 isoform 1						axon guidance|cell adhesion|transport	microtubule|plasma membrane				central_nervous_system(3)|ovary(1)	4	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0934)														---	---	---	---
STT3A	3703	broad.mit.edu	37	11	125481184	125481184	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:125481184delT	uc001qcd.2	+						STT3A_uc001qce.2_Intron|STT3A_uc010sbg.1_Intron|STT3A_uc009zbn.2_Intron	NM_152713	NP_689926			integral membrane protein 1						post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity				0	all_hematologic(175;0.228)	Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0919)|all_lung(97;0.0994)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0996)														---	---	---	---
CHEK1	1111	broad.mit.edu	37	11	125496889	125496889	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:125496889delA	uc009zbo.2	+						CHEK1_uc010sbh.1_Intron|CHEK1_uc010sbi.1_Intron|CHEK1_uc001qcf.3_Intron|CHEK1_uc009zbp.2_Intron|CHEK1_uc001qcg.3_Intron|CHEK1_uc009zbq.2_Intron|CHEK1_uc001qci.1_Intron	NM_001114122	NP_001107594			checkpoint kinase 1						cellular response to mechanical stimulus|DNA repair|DNA replication|gamete generation|negative regulation of cell proliferation|reciprocal meiotic recombination|regulation of cyclin-dependent protein kinase activity|replicative senescence	condensed nuclear chromosome|microtubule organizing center|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(3)|lung(2)|skin(1)	6	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0748)									Other_conserved_DNA_damage_response_genes					---	---	---	---
ACRV1	56	broad.mit.edu	37	11	125542254	125542254	+	3'UTR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:125542254delA	uc001qcs.2	-	4					CHEK1_uc001qcf.3_Intron|ACRV1_uc001qck.2_3'UTR|ACRV1_uc001qcl.2_3'UTR|ACRV1_uc001qcm.2_3'UTR|ACRV1_uc001qcn.2_3'UTR|ACRV1_uc001qco.2_3'UTR|ACRV1_uc001qcp.2_3'UTR|ACRV1_uc001qcq.2_3'UTR|ACRV1_uc001qcr.2_3'UTR	NM_001612	NP_001603			acrosomal vesicle protein 1 isoform a precursor						multicellular organismal development	acrosomal vesicle					0	all_hematologic(175;0.177)	Breast(109;0.0021)|all_lung(97;0.0179)|Lung NSC(97;0.0185)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0713)														---	---	---	---
IGSF9B	22997	broad.mit.edu	37	11	133789014	133789015	+	Intron	DEL	GG	-	-	rs72000603		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:133789014_133789015delGG	uc001qgx.3	-							NM_014987	NP_055802			immunoglobulin superfamily, member 9B							integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)														---	---	---	---
NCAPD3	23310	broad.mit.edu	37	11	134072805	134072805	+	Intron	DEL	A	-	-	rs34989286		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:134072805delA	uc001qhd.1	-						NCAPD3_uc010scm.1_Intron|NCAPD3_uc009zda.1_Intron	NM_015261	NP_056076			non-SMC condensin II complex, subunit D3						cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	5	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)														---	---	---	---
IQSEC3	440073	broad.mit.edu	37	12	271387	271387	+	Intron	DEL	T	-	-	rs66703624		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:271387delT	uc001qhw.1	+						IQSEC3_uc001qhu.1_Intron	NM_015232	NP_056047			IQ motif and Sec7 domain 3						regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)														---	---	---	---
WNK1	65125	broad.mit.edu	37	12	971210	971211	+	Intron	DEL	TC	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:971210_971211delTC	uc001qio.3	+						WNK1_uc001qip.3_Intron|WNK1_uc001qir.3_Intron	NM_018979	NP_061852			WNK lysine deficient protein kinase 1						intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)															---	---	---	---
ADIPOR2	79602	broad.mit.edu	37	12	1863751	1863751	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:1863751delA	uc001qjm.2	+						ADIPOR2_uc001qjn.2_Intron	NM_024551	NP_078827			adiponectin receptor 2						fatty acid oxidation|hormone-mediated signaling pathway	integral to membrane	hormone binding|receptor activity				0	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000382)															---	---	---	---
CACNA2D4	93589	broad.mit.edu	37	12	1909657	1909657	+	Intron	DEL	C	-	-	rs111637110		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:1909657delC	uc001qjp.2	-						CACNA2D4_uc009zds.1_Intron|CACNA2D4_uc001qjo.2_Intron|CACNA2D4_uc001qjs.1_Intron|CACNA2D4_uc010sdw.1_Intron|CACNA2D4_uc009zdr.1_Intron	NM_172364	NP_758952			voltage-gated calcium channel alpha(2)delta-4							integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			ovary(1)	1	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)												OREG0021569	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
CACNA1C	775	broad.mit.edu	37	12	2743051	2743051	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:2743051delA	uc009zdu.1	+						CACNA1C_uc009zdv.1_Intron|CACNA1C_uc001qkb.2_Intron|CACNA1C_uc001qkc.2_Intron|CACNA1C_uc001qke.2_Intron|CACNA1C_uc001qkf.2_Intron|CACNA1C_uc001qjz.2_Intron|CACNA1C_uc001qkd.2_Intron|CACNA1C_uc001qkg.2_Intron|CACNA1C_uc009zdw.1_Intron|CACNA1C_uc001qkh.2_Intron|CACNA1C_uc001qkl.2_Intron|CACNA1C_uc001qkn.2_Intron|CACNA1C_uc001qko.2_Intron|CACNA1C_uc001qkp.2_Intron|CACNA1C_uc001qkr.2_Intron|CACNA1C_uc001qku.2_Intron|CACNA1C_uc001qkq.2_Intron|CACNA1C_uc001qks.2_Intron|CACNA1C_uc001qkt.2_Intron|CACNA1C_uc001qki.1_Intron|CACNA1C_uc001qkj.1_Intron|CACNA1C_uc001qkk.1_Intron|CACNA1C_uc001qkm.1_Intron	NM_199460	NP_955630			calcium channel, voltage-dependent, L type,						axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)													---	---	---	---
CACNA1C	775	broad.mit.edu	37	12	2786183	2786184	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:2786183_2786184insA	uc009zdu.1	+						CACNA1C_uc009zdv.1_Intron|CACNA1C_uc001qkb.2_Intron|CACNA1C_uc001qkc.2_Intron|CACNA1C_uc001qke.2_Intron|CACNA1C_uc001qkf.2_Intron|CACNA1C_uc001qjz.2_Intron|CACNA1C_uc001qkd.2_Intron|CACNA1C_uc001qkg.2_Intron|CACNA1C_uc009zdw.1_Intron|CACNA1C_uc001qkh.2_Intron|CACNA1C_uc001qkl.2_Intron|CACNA1C_uc001qkn.2_Intron|CACNA1C_uc001qko.2_Intron|CACNA1C_uc001qkp.2_Intron|CACNA1C_uc001qkr.2_Intron|CACNA1C_uc001qku.2_Intron|CACNA1C_uc001qkq.2_Intron|CACNA1C_uc001qks.2_Intron|CACNA1C_uc001qkt.2_Intron|CACNA1C_uc001qki.1_Intron|CACNA1C_uc001qkj.1_Intron|CACNA1C_uc001qkk.1_Intron|CACNA1C_uc001qkm.1_Intron|CACNA1C_uc010sea.1_Intron|uc001qkx.1_RNA|CACNA1C_uc001qky.1_5'Flank	NM_199460	NP_955630			calcium channel, voltage-dependent, L type,						axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)													---	---	---	---
C12orf4	57102	broad.mit.edu	37	12	4634594	4634595	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:4634594_4634595insA	uc001qms.2	-						C12orf4_uc001qmt.2_Intron	NM_020374	NP_065107			hypothetical protein LOC57102												0			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)	BRCA - Breast invasive adenocarcinoma(232;0.0281)														---	---	---	---
C12orf4	57102	broad.mit.edu	37	12	4638925	4638925	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:4638925delT	uc001qms.2	-						C12orf4_uc001qmt.2_Intron	NM_020374	NP_065107			hypothetical protein LOC57102												0			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)	BRCA - Breast invasive adenocarcinoma(232;0.0281)														---	---	---	---
RAD51AP1	10635	broad.mit.edu	37	12	4653217	4653217	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:4653217delT	uc001qmw.2	+						RAD51AP1_uc001qmu.2_Intron|RAD51AP1_uc001qmv.2_Intron|RAD51AP1_uc010sep.1_Intron|RAD51AP1_uc010seq.1_Intron	NM_001130862	NP_001124334			RAD51 associated protein 1 isoform a						double-strand break repair via homologous recombination		double-stranded DNA binding|protein binding|protein binding|RNA binding|single-stranded DNA binding				0			Colorectal(7;0.00306)|COAD - Colon adenocarcinoma(12;0.0389)															---	---	---	---
RAD51AP1	10635	broad.mit.edu	37	12	4667939	4667939	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:4667939delT	uc001qmw.2	+						RAD51AP1_uc001qmu.2_Intron|RAD51AP1_uc001qmv.2_Intron|RAD51AP1_uc010sep.1_Intron|RAD51AP1_uc010seq.1_Intron|RAD51AP1_uc009zeg.2_Intron	NM_001130862	NP_001124334			RAD51 associated protein 1 isoform a						double-strand break repair via homologous recombination		double-stranded DNA binding|protein binding|protein binding|RNA binding|single-stranded DNA binding				0			Colorectal(7;0.00306)|COAD - Colon adenocarcinoma(12;0.0389)															---	---	---	---
IFFO1	25900	broad.mit.edu	37	12	6656906	6656907	+	Intron	DEL	AG	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:6656906_6656907delAG	uc001qpd.1	-						IFFO1_uc001qoy.2_Intron|IFFO1_uc001qpa.1_Intron|IFFO1_uc001qpb.1_Intron|IFFO1_uc001qpe.1_Intron|IFFO1_uc010sfe.1_Intron|IFFO1_uc001qpf.1_Intron|IFFO1_uc001qoz.1_Intron|IFFO1_uc001qpc.1_Intron|IFFO1_uc001qpg.2_Intron	NM_080730	NP_542768			intermediate filament family orphan isoform 2							intermediate filament					0																		---	---	---	---
CHD4	1108	broad.mit.edu	37	12	6704291	6704292	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:6704291_6704292delTT	uc001qpo.2	-						CHD4_uc001qpn.2_Intron|CHD4_uc001qpp.2_Intron	NM_001273	NP_001264			chromodomain helicase DNA binding protein 4						chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2																		---	---	---	---
C1R	715	broad.mit.edu	37	12	7187997	7187997	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:7187997delC	uc010sfy.1	-	10	2016	c.1957delG	c.(1957-1959)GATfs	p.D653fs		NM_001733	NP_001724	P00736	C1R_HUMAN	complement component 1, r subcomponent	653	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity				0					Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)													---	---	---	---
C1R	715	broad.mit.edu	37	12	7241600	7241600	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:7241600delT	uc010sfy.1	-						C1R_uc010sfz.1_Intron|C1R_uc010sga.1_Intron	NM_001733	NP_001724			complement component 1, r subcomponent						complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity				0					Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)													---	---	---	---
C1R	715	broad.mit.edu	37	12	7242010	7242010	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:7242010delG	uc010sfy.1	-	5	706	c.647delC	c.(646-648)CCTfs	p.P216fs	C1R_uc010sfz.1_Frame_Shift_Del_p.P230fs|C1R_uc010sga.1_Frame_Shift_Del_p.P182fs	NM_001733	NP_001724	P00736	C1R_HUMAN	complement component 1, r subcomponent	216	CUB 2.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity				0					Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)													---	---	---	---
CD163L1	283316	broad.mit.edu	37	12	7527765	7527765	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:7527765delC	uc001qsy.2	-						CD163L1_uc010sge.1_Intron	NM_174941	NP_777601			scavenger receptor cysteine-rich type 1							extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11																		---	---	---	---
CD163L1	283316	broad.mit.edu	37	12	7551740	7551743	+	Intron	DEL	CTTC	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:7551740_7551743delCTTC	uc001qsy.2	-						CD163L1_uc010sge.1_Intron	NM_174941	NP_777601			scavenger receptor cysteine-rich type 1							extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11																		---	---	---	---
CD163L1	283316	broad.mit.edu	37	12	7592370	7592370	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:7592370delC	uc001qsy.2	-						CD163L1_uc010sge.1_Intron	NM_174941	NP_777601			scavenger receptor cysteine-rich type 1							extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11																		---	---	---	---
CLEC4D	338339	broad.mit.edu	37	12	8674037	8674038	+	3'UTR	DEL	TG	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:8674037_8674038delTG	uc001qun.2	+	6						NM_080387	NP_525126			C-type lectin domain family 4, member D						innate immune response	integral to membrane	sugar binding				0	Lung SC(5;0.184)																	---	---	---	---
PZP	5858	broad.mit.edu	37	12	9313518	9313518	+	Intron	DEL	T	-	-	rs7972015	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:9313518delT	uc001qvl.2	-						PZP_uc009zgl.2_Intron|PZP_uc010sgo.1_Intron	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5																		---	---	---	---
KLRF1	51348	broad.mit.edu	37	12	9994590	9994590	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:9994590delA	uc010sgw.1	+						KLRF1_uc009zgw.2_Intron|KLRF1_uc009zgx.2_Intron|KLRF1_uc001qwm.2_Intron|KLRF1_uc009zgy.2_Intron|KLRF1_uc009zgz.2_Intron|KLRF1_uc009zha.2_Intron	NM_016523	NP_057607			killer cell lectin-like receptor subfamily F,						cell surface receptor linked signaling pathway	integral to plasma membrane	MHC class I receptor activity|sugar binding			large_intestine(1)	1																		---	---	---	---
CLEC9A	283420	broad.mit.edu	37	12	10193879	10193879	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:10193879delA	uc001qxa.2	+							NM_207345	NP_997228			C-type lectin domain family 9, member A						positive regulation of cytokine secretion|receptor-mediated endocytosis	cell surface|integral to membrane	receptor activity|sugar binding			ovary(1)	1																		---	---	---	---
KLRC3	3823	broad.mit.edu	37	12	10586195	10586195	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:10586195delA	uc001qyh.2	-						KLRC2_uc010she.1_Intron|KLRC2_uc001qyk.2_Intron	NM_002261	NP_002252			killer cell lectin-like receptor subfamily C,						cellular defense response	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|skin(1)	3																		---	---	---	---
Unknown	0	broad.mit.edu	37	12	10660065	10660065	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:10660065delT								KLRC1 (53081 upstream) : KLRA1 (81013 downstream)																																			---	---	---	---
PRB4	5545	broad.mit.edu	37	12	11285719	11285720	+	Intron	INS	-	AC	AC	rs146193223	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:11285719_11285720insAC	uc001qzf.1	-						PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRH1_uc001qzj.2_Intron	NM_002723	NP_002714			proline-rich protein BstNI subfamily 4							extracellular region				ovary(1)	1															HNSCC(22;0.051)			---	---	---	---
ETV6	2120	broad.mit.edu	37	12	12264842	12264842	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:12264842delA	uc001raa.1	+						BCL2L14_uc001raf.1_Intron	NM_001987	NP_001978			ets variant 6							cytoplasm|nucleolus	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		ETV6/NTRK3(234)|ETV6/JAK2(11)	soft_tissue(85)|kidney(66)|breast(55)|salivary_gland(26)|haematopoietic_and_lymphoid_tissue(13)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)|pancreas(1)	250		all_cancers(2;1.88e-12)|Acute lymphoblastic leukemia(2;6.91e-39)|all_hematologic(2;2.7e-36)						T	NTRK3|RUNX1|PDGFRB|ABL1|MN1|ABL2|FACL6|CHIC2|ARNT|JAK2|EVI1|CDX2|STL|HLXB9|MDS2|PER1|SYK|TTL|FGFR3|PAX5	congenital fibrosarcoma|multiple leukemia and lymphoma| secretory breast|MDS|ALL								---	---	---	---
ATF7IP	55729	broad.mit.edu	37	12	14577801	14577802	+	Frame_Shift_Ins	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:14577801_14577802insA	uc001rbw.2	+	2	1110_1111	c.952_953insA	c.(952-954)GAAfs	p.E318fs	ATF7IP_uc010shs.1_Frame_Shift_Ins_p.E318fs|ATF7IP_uc001rbu.2_Frame_Shift_Ins_p.E318fs|ATF7IP_uc001rbv.1_Frame_Shift_Ins_p.E318fs|ATF7IP_uc001rbx.2_Frame_Shift_Ins_p.E318fs|ATF7IP_uc010sht.1_Frame_Shift_Ins_p.E318fs|ATF7IP_uc001rby.3_Frame_Shift_Ins_p.E318fs|ATF7IP_uc001rbz.1_Frame_Shift_Ins_p.E318fs|ATF7IP_uc001rca.2_Frame_Shift_Ins_p.E318fs|ATF7IP_uc001rcb.2_5'Flank	NM_018179	NP_060649	Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting	318					DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			lung(3)|ovary(1)|skin(1)	5																		---	---	---	---
ATF7IP	55729	broad.mit.edu	37	12	14590987	14590987	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:14590987delA	uc001rbw.2	+						ATF7IP_uc010shs.1_Intron|ATF7IP_uc001rbu.2_Intron|ATF7IP_uc001rbv.1_Intron|ATF7IP_uc001rbx.2_Intron|ATF7IP_uc010sht.1_Intron|ATF7IP_uc001rby.3_Intron|ATF7IP_uc001rca.2_Intron	NM_018179	NP_060649			activating transcription factor 7 interacting						DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			lung(3)|ovary(1)|skin(1)	5																		---	---	---	---
ART4	420	broad.mit.edu	37	12	14993875	14993876	+	Frame_Shift_Del	DEL	GT	-	-	rs144350521	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:14993875_14993876delGT	uc001rcl.1	-	2	722_723	c.356_357delAC	c.(355-357)CACfs	p.H119fs	ART4_uc009zid.1_Intron|ART4_uc009zie.1_Intron|ART4_uc001rcm.1_Frame_Shift_Del_p.H119fs	NM_021071	NP_066549	Q93070	NAR4_HUMAN	ADP-ribosyltransferase 4 precursor	119					arginine metabolic process|protein ADP-ribosylation	anchored to membrane|plasma membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity				0																		---	---	---	---
PDE6H	5149	broad.mit.edu	37	12	15130881	15130881	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:15130881delT	uc001rcr.2	+							NM_006205	NP_006196			phosphodiesterase 6H						visual perception		3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|enzyme inhibitor activity			ovary(1)|skin(1)	2																		---	---	---	---
SLCO1C1	53919	broad.mit.edu	37	12	20905167	20905169	+	Intron	DEL	TAT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:20905167_20905169delTAT	uc001rej.3	+						SLCO1C1_uc010sii.1_Intron|SLCO1C1_uc010sij.1_Intron|SLCO1C1_uc009zip.2_Intron|SLCO1C1_uc001rei.2_Intron|SLCO1C1_uc010sik.1_Intron	NM_017435	NP_059131			solute carrier organic anion transporter family,						sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)																	---	---	---	---
KIAA0528	9847	broad.mit.edu	37	12	22624482	22624482	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:22624482delT	uc001rfq.2	-						KIAA0528_uc010sir.1_Intron|KIAA0528_uc010sis.1_Intron|KIAA0528_uc010sit.1_Intron|KIAA0528_uc010siu.1_Intron|KIAA0528_uc001rfr.2_Intron	NM_014802	NP_055617			hypothetical protein LOC9847								protein binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4																		---	---	---	---
SOX5	6660	broad.mit.edu	37	12	23887578	23887578	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:23887578delT	uc001rfw.2	-						SOX5_uc001rfx.2_Intron|SOX5_uc001rfy.2_Intron|SOX5_uc010siv.1_Intron|SOX5_uc010siw.1_Intron|SOX5_uc001rfz.1_Intron	NM_006940	NP_008871			SRY (sex determining region Y)-box 5 isoform a						transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6																		---	---	---	---
ARNTL2	56938	broad.mit.edu	37	12	27523049	27523052	+	Intron	DEL	TCCT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:27523049_27523052delTCCT	uc001rht.1	+						ARNTL2_uc001rhw.2_Intron|ARNTL2_uc010sjp.1_Intron|ARNTL2_uc001rhu.1_Intron|ARNTL2_uc009zji.1_Intron|ARNTL2_uc001rhv.1_Intron	NM_020183	NP_064568			aryl hydrocarbon receptor nuclear						circadian rhythm|entrainment of circadian clock|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(1)|skin(1)	2	Colorectal(261;0.0847)|Lung SC(9;0.184)																	---	---	---	---
PPFIBP1	8496	broad.mit.edu	37	12	27841020	27841020	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:27841020delA	uc001ric.1	+						PPFIBP1_uc010sjr.1_Intron|PPFIBP1_uc001rib.1_Intron|PPFIBP1_uc001ria.2_Intron|PPFIBP1_uc001rid.1_Intron|PPFIBP1_uc001rif.1_Intron	NM_003622	NP_003613			PTPRF interacting protein binding protein 1						cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	soft_tissue(3)|kidney(1)|skin(1)	5	Lung SC(9;0.0873)																	---	---	---	---
TMTC1	83857	broad.mit.edu	37	12	29736558	29736558	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:29736558delC	uc001rjb.2	-						TMTC1_uc001riz.2_Intron|TMTC1_uc001rja.2_Intron|TMTC1_uc001rjc.1_Intron	NM_175861	NP_787057			transmembrane and tetratricopeptide repeat							integral to membrane	binding				0	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)																	---	---	---	---
Unknown	0	broad.mit.edu	37	12	38926648	38926649	+	IGR	INS	-	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:38926648_38926649insC								ALG10B (203121 upstream) : CPNE8 (119353 downstream)																																			---	---	---	---
KIF21A	55605	broad.mit.edu	37	12	39713784	39713784	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:39713784delT	uc001rly.2	-	28	3849	c.3703delA	c.(3703-3705)ATTfs	p.I1235fs	KIF21A_uc001rlv.2_Frame_Shift_Del_p.I240fs|KIF21A_uc001rlw.2_Frame_Shift_Del_p.I552fs|KIF21A_uc001rlx.2_Frame_Shift_Del_p.I1222fs|KIF21A_uc001rlz.2_Frame_Shift_Del_p.I1199fs|KIF21A_uc010skl.1_Frame_Shift_Del_p.I1215fs|KIF21A_uc001rlu.2_5'UTR	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	1235					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)																---	---	---	---
KIF21A	55605	broad.mit.edu	37	12	39750759	39750759	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:39750759delA	uc001rly.2	-						KIF21A_uc001rlx.2_Intron|KIF21A_uc001rlz.2_Intron|KIF21A_uc010skl.1_Intron|KIF21A_uc001rma.1_Intron	NM_017641	NP_060111			kinesin family member 21A						microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)																---	---	---	---
C12orf40	283461	broad.mit.edu	37	12	40041836	40041836	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:40041836delT	uc001rmc.2	+						C12orf40_uc009zjv.1_Intron	NM_001031748	NP_001026918			hypothetical protein LOC283461											ovary(6)	6																		---	---	---	---
LRRK2	120892	broad.mit.edu	37	12	40671669	40671669	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:40671669delT	uc001rmg.3	+						LRRK2_uc001rmh.1_Intron	NM_198578	NP_940980			leucine-rich repeat kinase 2						activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)																---	---	---	---
LRRK2	120892	broad.mit.edu	37	12	40704083	40704083	+	Intron	DEL	A	-	-	rs34761947		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:40704083delA	uc001rmg.3	+						LRRK2_uc009zjw.2_Intron|LRRK2_uc001rmi.2_Intron	NM_198578	NP_940980			leucine-rich repeat kinase 2						activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)																---	---	---	---
RPAP3	79657	broad.mit.edu	37	12	48091573	48091573	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:48091573delA	uc001rpr.2	-						RPAP3_uc010slk.1_Intron|RPAP3_uc001rps.2_Intron	NM_024604	NP_078880			RNA polymerase II associated protein 3 isoform								binding			ovary(1)	1	Lung SC(27;0.192)																	---	---	---	---
VDR	7421	broad.mit.edu	37	12	48249317	48249317	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:48249317delA	uc001rqm.2	-						VDR_uc001rql.2_Intron|VDR_uc001rqn.2_Intron|VDR_uc010slq.1_Intron	NM_001017535	NP_001017535			vitamin D (1,25-dihydroxyvitamin D3) receptor						decidualization|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of vitamin D 24-hydroxylase activity|regulation of calcidiol 1-monooxygenase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid X receptor binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|vitamin D3 receptor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Acute lymphoblastic leukemia(13;0.109)|all_hematologic(14;0.214)		GBM - Glioblastoma multiforme(48;0.17)	Calcidiol(DB00146)|Calcipotriol(DB02300)|Calcitriol(DB00136)|Dihydrotachysterol(DB01070)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)													---	---	---	---
MLL2	8085	broad.mit.edu	37	12	49443667	49443667	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49443667delC	uc001rta.3	-	11	3704	c.3704delG	c.(3703-3705)GGTfs	p.G1235fs		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1235					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41								N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			---	---	---	---
MLL2	8085	broad.mit.edu	37	12	49448408	49448408	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49448408delC	uc001rta.3	-	3	303	c.303delG	c.(301-303)GGGfs	p.G101fs		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	101					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41								N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			---	---	---	---
SPATS2	65244	broad.mit.edu	37	12	49893816	49893816	+	Intron	DEL	T	-	-	rs71812288		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49893816delT	uc001rud.2	+						SPATS2_uc001rue.2_Intron|SPATS2_uc009zli.1_Intron|SPATS2_uc001ruf.2_Intron|SPATS2_uc001rug.2_Intron	NM_023071	NP_075559			spermatogenesis associated, serine-rich 2							cytoplasm				breast(1)	1																		---	---	---	---
ACCN2	41	broad.mit.edu	37	12	50453038	50453039	+	Intron	INS	-	C	C	rs144549190	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:50453038_50453039insC	uc001rvw.2	+						ACCN2_uc001rvv.2_Intron|ACCN2_uc009zln.2_Intron|ACCN2_uc009zlo.2_Intron	NM_001095	NP_001086			amiloride-sensitive cation channel 2, neuronal						calcium ion transport|response to pH|signal transduction	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(1)	1					Amiloride(DB00594)													---	---	---	---
DIP2B	57609	broad.mit.edu	37	12	51019634	51019634	+	Intron	DEL	C	-	-	rs66747566		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:51019634delC	uc001rwv.2	+						DIP2B_uc001rwu.2_Intron	NM_173602	NP_775873			DIP2 disco-interacting protein 2 homolog B							nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6																		---	---	---	---
ATF1	466	broad.mit.edu	37	12	51174134	51174134	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:51174134delT	uc001rww.3	+						ATF1_uc010smu.1_Intron	NM_005171	NP_005162			activating transcription factor 1						innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway				EWSR1/ATF1(323)|FUS/ATF1(4)	soft_tissue(321)|ovary(2)|NS(2)|bone(2)|skin(2)	329								T	EWSR1|FUS	malignant melanoma of soft parts |angiomatoid fibrous histiocytoma 								---	---	---	---
CELA1	1990	broad.mit.edu	37	12	51736568	51736568	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:51736568delT	uc001ryi.1	-							NM_001971	NP_001962			chymotrypsin-like elastase family, member 1						proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			breast(1)	1																		---	---	---	---
KRT2	3849	broad.mit.edu	37	12	53042647	53042647	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:53042647delC	uc001sat.2	-							NM_000423	NP_000414			keratin 2						keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.19)														---	---	---	---
SOAT2	8435	broad.mit.edu	37	12	53499311	53499311	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:53499311delT	uc001sbv.2	+						SOAT2_uc009zms.2_Intron	NM_003578	NP_003569			acyl-CoA:cholesterol acyltransferase 2						cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|macrophage derived foam cell differentiation|very-low-density lipoprotein particle assembly	brush border|endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			ovary(1)	1																		---	---	---	---
AMHR2	269	broad.mit.edu	37	12	53818451	53818452	+	Intron	INS	-	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:53818451_53818452insC	uc001scx.1	+						AMHR2_uc009zmy.1_Intron	NM_020547	NP_065434			anti-Mullerian hormone receptor, type II isoform						Mullerian duct regression		ATP binding|hormone binding|metal ion binding			ovary(1)|skin(1)	2					Adenosine triphosphate(DB00171)									Persistant_Mullerian_Duct_Syndrome_(type_I_and_II)				---	---	---	---
PCBP2	5094	broad.mit.edu	37	12	53849431	53849431	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:53849431delT	uc001sdl.3	+						PCBP2_uc001sdc.3_Intron|PCBP2_uc001sdb.3_Intron|PCBP2_uc001sde.3_Intron|PCBP2_uc001sdi.3_Intron|PCBP2_uc001sdd.3_Intron|PCBP2_uc001sdf.3_Intron|PCBP2_uc009zna.2_Intron|PCBP2_uc010soh.1_Intron|PCBP2_uc009zmz.1_Intron	NM_001128911	NP_001122383			poly(rC) binding protein 2 isoform d						innate immune response|negative regulation of defense response to virus|negative regulation of type I interferon production|nuclear mRNA splicing, via spliceosome|proteasomal ubiquitin-dependent protein catabolic process|response to virus	cytosol|nucleoplasm|ribonucleoprotein complex	DNA binding|RNA binding|ubiquitin protein ligase binding				0																		---	---	---	---
HNRNPA1	3178	broad.mit.edu	37	12	54676166	54676166	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:54676166delT	uc001sfl.2	+						CBX5_uc001sfk.3_5'Flank|CBX5_uc001sfi.3_5'Flank|HNRNPA1_uc001sfm.2_Intron|HNRNPA1_uc009zng.2_Intron|HNRNPA1_uc009znh.2_Intron|HNRNPA1_uc009zni.2_Intron|HNRNPA1_uc001sfn.2_Intron|HNRNPA1_uc001sfo.3_Intron|HNRNPA1_uc001sfp.1_Intron|HNRNPA1_uc009znj.1_Intron	NM_031157	NP_112420			heterogeneous nuclear ribonucleoprotein A1						interspecies interaction between organisms|mRNA transport|nuclear import	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|single-stranded DNA binding			skin(2)|ovary(1)	3																		---	---	---	---
Unknown	0	broad.mit.edu	37	12	55805997	55805997	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:55805997delT								OR6C65 (10748 upstream) : OR6C76 (14041 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	12	55808513	55808513	+	IGR	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:55808513delC								OR6C65 (13264 upstream) : OR6C76 (11525 downstream)																																			---	---	---	---
SMARCC2	6601	broad.mit.edu	37	12	56561674	56561675	+	Intron	DEL	AC	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56561674_56561675delAC	uc001skb.2	-						SMARCC2_uc001skd.2_Intron|SMARCC2_uc001ska.2_Intron|SMARCC2_uc001skc.2_Intron|SMARCC2_uc010sqf.1_Intron	NM_003075	NP_003066			SWI/SNF-related matrix-associated						chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			lung(2)|central_nervous_system(2)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(18;0.123)															---	---	---	---
Unknown	0	broad.mit.edu	37	12	56775604	56775604	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56775604delA								APOF (19021 upstream) : TIMELESS (34553 downstream)																																			---	---	---	---
PTGES3	10728	broad.mit.edu	37	12	57059872	57059872	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57059872delT	uc001slu.3	-						PTGES3_uc001slw.3_RNA|PTGES3_uc010sqs.1_Intron|PTGES3_uc001slv.3_Intron|PTGES3_uc010sqt.1_Intron|PTGES3_uc009zox.2_Intron	NM_006601	NP_006592			prostaglandin-E synthase 3						chaperone cofactor-dependent protein refolding|hormone biosynthetic process|prostaglandin biosynthetic process|signal transduction|telomere maintenance	cytosol|telomerase holoenzyme complex	prostaglandin-E synthase activity|telomerase activity|unfolded protein binding				0																		---	---	---	---
NACA	4666	broad.mit.edu	37	12	57106300	57106300	+	3'UTR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57106300delA	uc001slz.2	-	8					NACA_uc001sly.2_3'UTR|NACA_uc009zoy.1_3'UTR|NACA_uc001smc.2_3'UTR|NACA_uc001sma.2_3'UTR|NACA_uc001smb.2_3'UTR|NACA_uc010squ.1_RNA	NM_001113201	NP_001106672			nascent polypeptide-associated complex alpha						interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			ovary(1)	1								T	BCL6	NHL								---	---	---	---
LRP1	4035	broad.mit.edu	37	12	57542755	57542755	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57542755delT	uc001snd.2	+						LRP1_uc010sre.1_Intron|LRP1_uc001snb.2_Intron|LRP1_uc001snc.1_Intron	NM_002332	NP_002323			low density lipoprotein-related protein 1						aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)													---	---	---	---
GLI1	2735	broad.mit.edu	37	12	57860075	57860075	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57860075delG	uc001snx.2	+	8	893	c.815delG	c.(814-816)TGGfs	p.W272fs	GLI1_uc009zpq.2_Frame_Shift_Del_p.W144fs	NM_005269	NP_005260	P08151	GLI1_HUMAN	GLI family zinc finger 1 isoform 1	272	C2H2-type 2.				epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			skin(4)|ovary(4)|breast(3)|central_nervous_system(1)|urinary_tract(1)|kidney(1)|pancreas(1)	15			GBM - Glioblastoma multiforme(3;3.99e-32)															---	---	---	---
MARS	4141	broad.mit.edu	37	12	57905367	57905367	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57905367delA	uc001sog.2	+						MARS_uc001sof.1_Intron|MARS_uc010srp.1_Intron|MARS_uc010srq.1_Intron|MARS_uc001soh.1_5'Flank	NM_004990	NP_004981			methionyl-tRNA synthetase						methionyl-tRNA aminoacylation	cytosol	ATP binding|methionine-tRNA ligase activity|protein binding|tRNA binding			ovary(3)|central_nervous_system(1)|pancreas(1)	5			GBM - Glioblastoma multiforme(3;4.27e-41)		L-Methionine(DB00134)													---	---	---	---
SLC26A10	65012	broad.mit.edu	37	12	58015698	58015698	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:58015698delC	uc001spe.2	+						SLC26A10_uc001spf.2_Intron|SLC26A10_uc009zpz.1_5'Flank	NM_133489	NP_597996			solute carrier family 26, member 10							integral to membrane	antiporter activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(17;0.122)															OREG0021948	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
Unknown	0	broad.mit.edu	37	12	59447283	59447285	+	IGR	DEL	CTC	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:59447283_59447285delCTC								LRIG3 (133021 upstream) : SLC16A7 (542563 downstream)																																			---	---	---	---
SRGAP1	57522	broad.mit.edu	37	12	64377821	64377821	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:64377821delA	uc010ssp.1	+	2	218	c.162delA	c.(160-162)CGAfs	p.R54fs	SRGAP1_uc001srt.2_Frame_Shift_Del_p.R54fs|SRGAP1_uc001srv.2_Frame_Shift_Del_p.R14fs	NM_020762	NP_065813	Q7Z6B7	SRGP1_HUMAN	SLIT-ROBO Rho GTPase activating protein 1	54	FCH.				axon guidance	cytosol				ovary(2)|central_nervous_system(2)	4			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)														---	---	---	---
XPOT	11260	broad.mit.edu	37	12	64811765	64811765	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:64811765delT	uc001ssb.2	+						XPOT_uc009zqm.1_Intron	NM_007235	NP_009166			tRNA exportin						intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(28;0.0404)														---	---	---	---
XPOT	11260	broad.mit.edu	37	12	64828782	64828782	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:64828782delT	uc001ssb.2	+							NM_007235	NP_009166			tRNA exportin						intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(28;0.0404)														---	---	---	---
Unknown	0	broad.mit.edu	37	12	66039649	66039649	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:66039649delA								MSRB3 (178969 upstream) : RPSAP52 (112154 downstream)																																			---	---	---	---
HMGA2	8091	broad.mit.edu	37	12	66221835	66221835	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:66221835delA	uc001ssx.2	+	2	977	c.166delA	c.(166-168)AAAfs	p.K56fs	RPSAP52_uc001sso.2_5'Flank|HMGA2_uc001ssw.1_Frame_Shift_Del_p.K56fs|HMGA2_uc001ssp.1_RNA|HMGA2_uc010ssv.1_RNA|HMGA2_uc001sss.1_RNA|HMGA2_uc001sst.1_Frame_Shift_Del_p.K56fs|HMGA2_uc001ssu.1_Frame_Shift_Del_p.K56fs|HMGA2_uc001ssv.2_Frame_Shift_Del_p.K56fs	NM_003483	NP_003474	P52926	HMGA2_HUMAN	high mobility group AT-hook 2 isoform a	56	Interaction with E4F1.				cell division|chromatin organization|mitosis|multicellular organismal development|regulation of growth|transcription, DNA-dependent	chromatin	AT DNA binding		HMGA2/LPP(161)|HMGA2/WIF1_ENST00000286574(14)|HMGA2/RAD51B(11)|HMGA2/NFIB_ENST00000397581(8)|HMGA2/FHIT_ENST00000476844(4)|HMGA2/CCNB1IP1(2)|HMGA2/ALDH2_ENST00000261733(2)|HMGA2/EBF1(2)|HMGA2/LHFP(2)|HMGA2/COX6C(2)	soft_tissue(159)|bone(27)|salivary_gland(22)	208	all_cancers(1;5.78e-46)		GBM - Glioblastoma multiforme(1;0.00179)|LUSC - Lung squamous cell carcinoma(43;0.156)	GBM - Glioblastoma multiforme(28;0.0386)				T	 LHFP|RAD51L1|LPP|HEI10|COX6C|CMKOR1|NFIB|ALDH2|CCNB1IP1|EBF1|WIF1|FHIT	lipoma|leiomyoma|pleiomorphic salivary gland adenoma								---	---	---	---
IRAK3	11213	broad.mit.edu	37	12	66642137	66642137	+	3'UTR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:66642137delA	uc001sth.2	+	12					IRAK3_uc010ssy.1_3'UTR	NM_007199	NP_009130			interleukin-1 receptor-associated kinase 3						interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			lung(3)|ovary(2)|breast(2)|central_nervous_system(1)	8				GBM - Glioblastoma multiforme(28;0.0203)														---	---	---	---
MDM1	56890	broad.mit.edu	37	12	68707200	68707200	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:68707200delT	uc001stz.2	-						MDM1_uc010stc.1_Intron|MDM1_uc009zqv.1_Intron	NM_017440	NP_059136			mouse Mdm1 nuclear protein homolog isoform 1							nucleus				ovary(3)|skin(2)	5			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000174)														---	---	---	---
MDM1	56890	broad.mit.edu	37	12	68709828	68709828	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:68709828delT	uc001stz.2	-						MDM1_uc010stc.1_Intron|MDM1_uc009zqv.1_Intron	NM_017440	NP_059136			mouse Mdm1 nuclear protein homolog isoform 1							nucleus				ovary(3)|skin(2)	5			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000174)														---	---	---	---
MDM2	4193	broad.mit.edu	37	12	69199184	69199184	+	5'Flank	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:69199184delT	uc001sui.2	+						MDM2_uc009zri.2_5'Flank|MDM2_uc009zqx.2_5'Flank|MDM2_uc009zqw.2_5'Flank|MDM2_uc001suk.2_5'Flank	NM_002392	NP_002383			mouse double minute 2 homolog isoform MDM2						cellular response to hypoxia|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|establishment of protein localization|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell cycle arrest|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein complex assembly|protein destabilization|protein localization to nucleus|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to antibiotic|synaptic transmission	cytosol|endocytic vesicle membrane|insoluble fraction|nucleolus|nucleoplasm|plasma membrane|protein complex	enzyme binding|identical protein binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|central_nervous_system(1)	3	all_cancers(1;8.46e-121)|all_epithelial(5;3.21e-36)|Lung NSC(4;2.16e-33)|all_lung(4;3.03e-31)|Glioma(1;1.9e-09)|Breast(13;1.59e-06)|all_neural(1;1.03e-05)|Melanoma(1;0.0171)|Renal(347;0.0684)		all cancers(2;8.67e-65)|GBM - Glioblastoma multiforme(2;8.89e-62)|BRCA - Breast invasive adenocarcinoma(5;2.43e-08)|Lung(24;1.5e-05)|LUAD - Lung adenocarcinoma(15;8.5e-05)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)					A		sarcoma|glioma|colorectal|other								---	---	---	---
MDM2	4193	broad.mit.edu	37	12	69229771	69229771	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:69229771delT	uc001sui.2	+						MDM2_uc009zri.2_Intron|MDM2_uc009zqx.2_Intron|MDM2_uc009zqw.2_Intron|MDM2_uc001suk.2_Intron|MDM2_uc001sun.3_Intron|MDM2_uc009zqz.2_Intron|MDM2_uc009zra.2_Intron|MDM2_uc001sum.1_Intron|MDM2_uc009zrd.2_Intron|MDM2_uc009zrc.2_Intron|MDM2_uc009zre.2_Intron|MDM2_uc009zrf.2_Intron|MDM2_uc001suo.2_Intron|MDM2_uc009zrg.2_Intron|MDM2_uc009zrh.2_Intron	NM_002392	NP_002383			mouse double minute 2 homolog isoform MDM2						cellular response to hypoxia|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|establishment of protein localization|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell cycle arrest|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein complex assembly|protein destabilization|protein localization to nucleus|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to antibiotic|synaptic transmission	cytosol|endocytic vesicle membrane|insoluble fraction|nucleolus|nucleoplasm|plasma membrane|protein complex	enzyme binding|identical protein binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|central_nervous_system(1)	3	all_cancers(1;8.46e-121)|all_epithelial(5;3.21e-36)|Lung NSC(4;2.16e-33)|all_lung(4;3.03e-31)|Glioma(1;1.9e-09)|Breast(13;1.59e-06)|all_neural(1;1.03e-05)|Melanoma(1;0.0171)|Renal(347;0.0684)		all cancers(2;8.67e-65)|GBM - Glioblastoma multiforme(2;8.89e-62)|BRCA - Breast invasive adenocarcinoma(5;2.43e-08)|Lung(24;1.5e-05)|LUAD - Lung adenocarcinoma(15;8.5e-05)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)					A		sarcoma|glioma|colorectal|other								---	---	---	---
CNOT2	4848	broad.mit.edu	37	12	70732385	70732385	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:70732385delT	uc001svv.2	+						CNOT2_uc009zro.2_Intron|CNOT2_uc009zrp.2_Intron|CNOT2_uc009zrq.2_Intron|CNOT2_uc001svw.1_Intron	NM_014515	NP_055330			CCR4-NOT transcription complex, subunit 2						nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	protein binding|RNA polymerase II transcription cofactor activity				0	Renal(347;0.236)		GBM - Glioblastoma multiforme(1;4.77e-09)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00243)|STAD - Stomach adenocarcinoma(21;0.0118)															---	---	---	---
PTPRR	5801	broad.mit.edu	37	12	71066303	71066303	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:71066303delA	uc001swi.1	-						PTPRR_uc001swh.1_Intron|PTPRR_uc009zrs.2_Intron|PTPRR_uc010stq.1_Intron|PTPRR_uc010str.1_Intron	NM_002849	NP_002840			protein tyrosine phosphatase, receptor type, R						in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			skin(2)|ovary(1)	3			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)														---	---	---	---
TSPAN8	7103	broad.mit.edu	37	12	71523013	71523013	+	Intron	DEL	T	-	-	rs112700480		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:71523013delT	uc009zrt.1	-						TSPAN8_uc001swk.1_Intron|TSPAN8_uc001swj.1_Intron	NM_004616	NP_004607			transmembrane 4 superfamily member 3						protein glycosylation	integral to membrane|lysosome	signal transducer activity			skin(2)|lung(1)|central_nervous_system(1)	4			LUSC - Lung squamous cell carcinoma(43;0.24)|OV - Ovarian serous cystadenocarcinoma(12;0.244)															---	---	---	---
KCNC2	3747	broad.mit.edu	37	12	75445117	75445117	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:75445117delA	uc001sxg.1	-						KCNC2_uc009zry.2_Intron|KCNC2_uc001sxe.2_Intron|KCNC2_uc001sxf.2_Intron|KCNC2_uc010stw.1_Intron	NM_139137	NP_631875			Shaw-related voltage-gated potassium channel						energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(2)|pancreas(2)|skin(1)|lung(1)	6																		---	---	---	---
BBS10	79738	broad.mit.edu	37	12	76740960	76740960	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:76740960delA	uc001syd.1	-	2	889	c.805delT	c.(805-807)TCCfs	p.S269fs		NM_024685	NP_078961	Q8TAM1	BBS10_HUMAN	Bardet-Biedl syndrome 10	269					cellular protein metabolic process|nonmotile primary cilium assembly|photoreceptor cell maintenance|response to stimulus|retina homeostasis	cilium	ATP binding			ovary(1)|skin(1)	2														Bardet-Biedl_syndrome				---	---	---	---
ZDHHC17	23390	broad.mit.edu	37	12	77203640	77203640	+	Intron	DEL	A	-	-	rs137909589		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:77203640delA	uc001syk.1	+						ZDHHC17_uc001syi.1_Intron|ZDHHC17_uc001syj.2_Intron	NM_015336	NP_056151			huntingtin interacting protein 14						lipoprotein transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi-associated vesicle membrane|integral to membrane	magnesium ion transmembrane transporter activity|protein binding|protein-cysteine S-palmitoleyltransferase activity|signal transducer activity|zinc ion binding				0																		---	---	---	---
NAV3	89795	broad.mit.edu	37	12	78392262	78392265	+	Intron	DEL	TGTT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:78392262_78392265delTGTT	uc001syp.2	+						NAV3_uc001syo.2_Intron	NM_014903	NP_055718			neuron navigator 3							nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17															HNSCC(70;0.22)			---	---	---	---
SYT1	6857	broad.mit.edu	37	12	79747092	79747092	+	Intron	DEL	A	-	-	rs143147207		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:79747092delA	uc001sys.2	+						SYT1_uc001syt.2_Intron|SYT1_uc001syu.2_Intron|SYT1_uc001syv.2_Intron	NM_001135805	NP_001129277			synaptotagmin I						detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			skin(3)|pancreas(2)|ovary(1)	6																		---	---	---	---
PAWR	5074	broad.mit.edu	37	12	79988067	79988067	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:79988067delA	uc001syx.2	-							NM_002583	NP_002574			PRKC, apoptosis, WT1, regulator						actin filament bundle assembly|apoptosis|induction of apoptosis|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	actin binding|enzyme binding|leucine zipper domain binding|transcription corepressor activity				0																		---	---	---	---
PPP1R12A	4659	broad.mit.edu	37	12	80169698	80169699	+	3'UTR	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:80169698_80169699delTT	uc001syz.2	-	25					PPP1R12A_uc010suc.1_3'UTR|PPP1R12A_uc001sza.2_3'UTR|PPP1R12A_uc010sud.1_3'UTR|PPP1R12A_uc001szb.2_3'UTR|PPP1R12A_uc001syy.2_RNA	NM_002480	NP_002471			protein phosphatase 1, regulatory (inhibitor)							contractile fiber	protein binding|signal transducer activity			ovary(2)|breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	7																		---	---	---	---
Unknown	0	broad.mit.edu	37	12	80656010	80656010	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:80656010delT								PPP1R12A (326775 upstream) : PTPRQ (182116 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	12	80658629	80658629	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:80658629delA								PPP1R12A (329394 upstream) : PTPRQ (179497 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	12	80714026	80714026	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:80714026delT								PPP1R12A (384791 upstream) : PTPRQ (124100 downstream)																																			---	---	---	---
LIN7A	8825	broad.mit.edu	37	12	81239456	81239456	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:81239456delA	uc001szj.1	-						LIN7A_uc001szk.1_Intron	NM_004664	NP_004655			lin-7 homolog A						exocytosis|protein complex assembly|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	L27 domain binding			ovary(1)|skin(1)	2																		---	---	---	---
LRRIQ1	84125	broad.mit.edu	37	12	85449618	85449618	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:85449618delA	uc001tac.2	+	8	1158	c.1047delA	c.(1045-1047)AGAfs	p.R349fs	LRRIQ1_uc001tab.1_Frame_Shift_Del_p.R349fs|LRRIQ1_uc001taa.1_Frame_Shift_Del_p.R324fs	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	349	Glu-rich.									ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)														---	---	---	---
LRRIQ1	84125	broad.mit.edu	37	12	85554294	85554294	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:85554294delT	uc001tac.2	+							NM_001079910	NP_001073379			leucine-rich repeats and IQ motif containing 1											ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)														---	---	---	---
TMTC3	160418	broad.mit.edu	37	12	88560085	88560085	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:88560085delT	uc001tau.2	+						TMTC3_uc009zsm.2_Intron	NM_181783	NP_861448			transmembrane and tetratricopeptide repeat							integral to membrane	binding			skin(1)	1																		---	---	---	---
DCN	1634	broad.mit.edu	37	12	91540129	91540136	+	Intron	DEL	TTTTTTTT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:91540129_91540136delTTTTTTTT	uc001tbs.2	-						DCN_uc001tbo.2_Intron|DCN_uc001tbp.2_Intron|DCN_uc001tbq.2_Intron|DCN_uc001tbr.2_Intron|DCN_uc001tbt.2_Intron|DCN_uc001tbu.2_Intron	NM_133503	NP_598010			decorin isoform a preproprotein						organ morphogenesis	extracellular space				central_nervous_system(2)|ovary(1)|lung(1)	4																		---	---	---	---
PLEKHG7	440107	broad.mit.edu	37	12	93163851	93163851	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:93163851delT	uc001tcj.2	+							NM_001004330	NP_001004330			pleckstrin homology domain containing, family G						regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1																		---	---	---	---
PLXNC1	10154	broad.mit.edu	37	12	94631377	94631377	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:94631377delT	uc001tdc.2	+							NM_005761	NP_005752			plexin C1 precursor						axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
PLXNC1	10154	broad.mit.edu	37	12	94690920	94690920	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:94690920delT	uc001tdc.2	+						PLXNC1_uc010sut.1_Intron|PLXNC1_uc009zsv.2_Intron	NM_005761	NP_005752			plexin C1 precursor						axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
NR2C1	7181	broad.mit.edu	37	12	95445724	95445724	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:95445724delA	uc001tdm.3	-						NR2C1_uc010suu.1_Intron|NR2C1_uc001tdo.3_Intron|NR2C1_uc001tdn.3_Intron	NM_003297	NP_003288			nuclear receptor subfamily 2, group C, member 1						regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	PML body	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1																		---	---	---	---
USP44	84101	broad.mit.edu	37	12	95911790	95911790	+	3'UTR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:95911790delA	uc001teg.2	-	6					USP44_uc001teh.2_3'UTR|USP44_uc009zte.2_3'UTR	NM_001042403	NP_001035862			ubiquitin thiolesterase 44						anaphase|cell division|mitosis|negative regulation of mitotic anaphase-promoting complex activity|protein deubiquitination|regulation of spindle checkpoint|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(1)|breast(1)|central_nervous_system(1)	3																		---	---	---	---
CCDC38	120935	broad.mit.edu	37	12	96288675	96288675	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:96288675delA	uc001tek.1	-							NM_182496	NP_872302			coiled-coil domain containing 38											skin(1)	1																		---	---	---	---
CCDC38	120935	broad.mit.edu	37	12	96292432	96292432	+	Frame_Shift_Del	DEL	T	-	-	rs142628960		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:96292432delT	uc001tek.1	-	6	681	c.447delA	c.(445-447)AAAfs	p.K149fs		NM_182496	NP_872302	Q502W7	CCD38_HUMAN	coiled-coil domain containing 38	149	Potential.									skin(1)	1																		---	---	---	---
LTA4H	4048	broad.mit.edu	37	12	96418448	96418450	+	Intron	DEL	TTT	-	-	rs5800241		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:96418448_96418450delTTT	uc001ten.1	-						LTA4H_uc010suy.1_Intron|LTA4H_uc010suz.1_Intron|LTA4H_uc010sva.1_Intron	NM_000895	NP_000886			leukotriene A4 hydrolase						hormone biosynthetic process|inflammatory response|leukotriene biosynthetic process|peptide catabolic process|prostanoid metabolic process|proteolysis	cytosol|nucleus	aminopeptidase activity|epoxide hydrolase activity|leukotriene-A4 hydrolase activity|metallopeptidase activity|protein binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)	1																		---	---	---	---
TMPO	7112	broad.mit.edu	37	12	98921672	98921672	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:98921672delA	uc001tfj.2	+	2	525	c.288delA	c.(286-288)ACAfs	p.T96fs	TMPO_uc001tfi.1_Frame_Shift_Del_p.T96fs|TMPO_uc001tfk.2_Frame_Shift_Del_p.T96fs|TMPO_uc001tfl.2_RNA|TMPO_uc001tfh.1_Frame_Shift_Del_p.T96fs	NM_001032283	NP_001027454	P42167	LAP2B_HUMAN	thymopoietin isoform beta	96	Linker.|Nucleoplasmic (Potential).					integral to membrane|nuclear inner membrane	DNA binding|lamin binding			ovary(2)	2																		---	---	---	---
ANKS1B	56899	broad.mit.edu	37	12	100175880	100175880	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:100175880delA	uc001tge.1	-						ANKS1B_uc001tgf.1_Intron|ANKS1B_uc009ztt.1_Intron	NM_152788	NP_690001			cajalin 2 isoform a							Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)														---	---	---	---
Unknown	0	broad.mit.edu	37	12	100402758	100402758	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:100402758delT								ANKS1B (24326 upstream) : UHRF1BP1L (28107 downstream)																																			---	---	---	---
UHRF1BP1L	23074	broad.mit.edu	37	12	100489623	100489623	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:100489623delA	uc001tgq.2	-						UHRF1BP1L_uc001tgr.2_Intron|UHRF1BP1L_uc001tgp.2_5'Flank	NM_015054	NP_055869			UHRF1 (ICBP90) binding protein 1-like isoform a											ovary(2)	2																		---	---	---	---
DEPDC4	120863	broad.mit.edu	37	12	100657163	100657163	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:100657163delT	uc001thi.2	-						DEPDC4_uc001thh.1_Intron|DEPDC4_uc001thj.1_Intron|DEPDC4_uc009ztv.1_Intron|DEPDC4_uc001thk.1_Intron|DEPDC4_uc001thl.1_Intron	NM_152317	NP_689530			DEP domain containing 4						intracellular signal transduction						0																		---	---	---	---
SLC17A8	246213	broad.mit.edu	37	12	100795814	100795814	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:100795814delA	uc010svi.1	+						SLC17A8_uc009ztx.2_Intron	NM_139319	NP_647480			solute carrier family 17 (sodium-dependent						neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)	3																		---	---	---	---
Unknown	0	broad.mit.edu	37	12	101818528	101818528	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:101818528delA								ARL1 (16956 upstream) : SPIC (50671 downstream)																																			---	---	---	---
HSP90B1	7184	broad.mit.edu	37	12	104340286	104340286	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:104340286delT	uc001tkb.1	+						HSP90B1_uc010swg.1_Intron|HSP90B1_uc009zui.1_Intron	NM_003299	NP_003290			heat shock protein 90kDa beta, member 1						actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			ovary(2)|skin(1)	3					Rifabutin(DB00615)													---	---	---	---
GLT8D2	83468	broad.mit.edu	37	12	104390451	104390451	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:104390451delG	uc001tkh.1	-						GLT8D2_uc001tki.1_Intron	NM_031302	NP_112592			glycosyltransferase 8 domain containing 2							integral to membrane	transferase activity, transferring glycosyl groups			ovary(1)|skin(1)	2																		---	---	---	---
PRDM4	11108	broad.mit.edu	37	12	108147900	108147900	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:108147900delT	uc001tmp.2	-						PRDM4_uc001tmq.2_Intron	NM_012406	NP_036538			PR domain containing 4						cell proliferation|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2																		---	---	---	---
CORO1C	23603	broad.mit.edu	37	12	109056094	109056094	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:109056094delT	uc001tnj.2	-						CORO1C_uc009zva.2_Intron|CORO1C_uc010sxf.1_Intron	NM_014325	NP_055140			coronin, actin binding protein, 1C isoform 1						actin cytoskeleton organization|phagocytosis|signal transduction	actin cytoskeleton	actin filament binding			skin(3)	3																		---	---	---	---
SSH1	54434	broad.mit.edu	37	12	109211984	109211984	+	Intron	DEL	A	-	-	rs75291911	byFrequency;by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:109211984delA	uc001tnm.2	-						SSH1_uc010sxg.1_Intron|SSH1_uc001tnn.3_Intron|SSH1_uc001tno.1_5'Flank	NM_018984	NP_061857			slingshot 1 isoform 1						actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(4)	4																		---	---	---	---
MYO1H	283446	broad.mit.edu	37	12	109838771	109838772	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:109838771_109838772insA	uc010sxn.1	+							NM_001101421	NP_001094891			myosin 1H							myosin complex	motor activity				0																		---	---	---	---
GIT2	9815	broad.mit.edu	37	12	110403605	110403605	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:110403605delA	uc001tps.2	-						GIT2_uc001tpq.2_Intron|GIT2_uc001tpv.2_Intron|GIT2_uc001tpu.2_Intron|GIT2_uc001tpt.2_Intron|GIT2_uc010sxu.1_Intron|GIT2_uc001tpw.2_Intron|GIT2_uc010sxv.1_Intron	NM_057169	NP_476510			G protein-coupled receptor kinase interacting						regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	nucleoplasm	ARF GTPase activator activity|protein binding|zinc ion binding			central_nervous_system(1)	1																		---	---	---	---
IFT81	28981	broad.mit.edu	37	12	110655832	110655832	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:110655832delT	uc001tqi.2	+						IFT81_uc001tqh.2_Intron|IFT81_uc001tqj.2_Intron	NM_001143779	NP_001137251			intraflagellar transport 81-like isoform 1						cell differentiation|multicellular organismal development|spermatogenesis	intraflagellar transport particle B|microtubule-based flagellum				ovary(1)	1																		---	---	---	---
ANAPC7	51434	broad.mit.edu	37	12	110834322	110834322	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:110834322delT	uc001tqo.2	-						ANAPC7_uc001tqp.3_Intron	NM_016238	NP_057322			anaphase-promoting complex subunit 7 isoform a						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding				0																		---	---	---	---
CUX2	23316	broad.mit.edu	37	12	111785947	111785948	+	Frame_Shift_Ins	INS	-	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:111785947_111785948insC	uc001tsa.1	+	22	4432_4433	c.4279_4280insC	c.(4279-4281)GCCfs	p.A1427fs		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	1427	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6																		---	---	---	---
ATXN2	6311	broad.mit.edu	37	12	111908553	111908553	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:111908553delA	uc001tsj.2	-						ATXN2_uc001tsh.2_Intron|ATXN2_uc001tsi.2_Intron|ATXN2_uc001tsk.2_Intron|ATXN2_uc001tsg.2_Intron|ATXN2_uc001tsl.1_Frame_Shift_Del_p.S17fs	NM_002973	NP_002964			ataxin 2						cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			ovary(1)|breast(1)	2																		---	---	---	---
ACAD10	80724	broad.mit.edu	37	12	112130849	112130849	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:112130849delG	uc001tsq.2	+						ACAD10_uc009zvw.2_Intron|ACAD10_uc001tso.3_Intron|ACAD10_uc001tsp.2_Intron|ACAD10_uc009zvx.2_Intron	NM_025247	NP_079523			acyl-Coenzyme A dehydrogenase family, member 10								acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			ovary(2)	2																		---	---	---	---
NAA25	80018	broad.mit.edu	37	12	112491483	112491483	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:112491483delA	uc001ttm.2	-						NAA25_uc001ttn.3_Intron|NAA25_uc009zvz.1_Intron|NAA25_uc009zwa.1_Intron	NM_024953	NP_079229			mitochondrial distribution and morphology 20							cytoplasm	protein binding			ovary(1)|breast(1)|pancreas(1)	3																		---	---	---	---
RPH3A	22895	broad.mit.edu	37	12	113307382	113307382	+	Intron	DEL	A	-	-	rs113867631		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:113307382delA	uc010syl.1	+						RPH3A_uc001ttz.2_Intron|RPH3A_uc001tty.2_Intron|RPH3A_uc009zwe.1_Intron|RPH3A_uc010sym.1_Intron|RPH3A_uc001tua.2_5'UTR	NM_001143854	NP_001137326			rabphilin 3A homolog isoform 1						intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			ovary(3)|central_nervous_system(2)|skin(2)	7				BRCA - Breast invasive adenocarcinoma(302;0.00453)														---	---	---	---
MED13L	23389	broad.mit.edu	37	12	116549356	116549356	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:116549356delA	uc001tvw.2	-							NM_015335	NP_056150			mediator complex subunit 13-like						regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)														---	---	---	---
FBXO21	23014	broad.mit.edu	37	12	117603583	117603583	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:117603583delA	uc001twk.2	-						FBXO21_uc001twj.2_Intron|FBXO21_uc009zwq.2_Intron|FBXO21_uc001twl.1_Intron	NM_033624	NP_296373			F-box only protein 21 isoform 1						ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			kidney(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0291)														---	---	---	---
NOS1	4842	broad.mit.edu	37	12	117703230	117703230	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:117703230delC	uc001twm.1	-	12	2713	c.2027delG	c.(2026-2028)GGCfs	p.G676fs		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	676					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)													---	---	---	---
WSB2	55884	broad.mit.edu	37	12	118481123	118481123	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:118481123delC	uc001twr.2	-	3	340	c.242delG	c.(241-243)GGCfs	p.G81fs	WSB2_uc010sza.1_5'UTR|WSB2_uc010szb.1_Intron|WSB2_uc009zws.1_Frame_Shift_Del_p.G81fs	NM_018639	NP_061109	Q9NYS7	WSB2_HUMAN	WD SOCS-box protein 2	81					intracellular signal transduction					ovary(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)																	---	---	---	---
VSIG10	54621	broad.mit.edu	37	12	118519823	118519829	+	Intron	DEL	AAAAAAA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:118519823_118519829delAAAAAAA	uc001tws.2	-							NM_019086	NP_061959			V-set and immunoglobulin domain containing 10							integral to membrane					0																		---	---	---	---
CIT	11113	broad.mit.edu	37	12	120194922	120194923	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:120194922_120194923delAA	uc001txi.1	-						CIT_uc001txh.1_Intron|CIT_uc001txj.1_Intron	NM_007174	NP_009105			citron						intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)														---	---	---	---
CCDC64	92558	broad.mit.edu	37	12	120510172	120510172	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:120510172delA	uc001txl.1	+						CCDC64_uc001txk.2_Intron|CCDC64_uc009zwv.1_Intron|CCDC64_uc010sze.1_Intron|CCDC64_uc010szf.1_Intron	NM_207311	NP_997194			coiled-coil domain containing 64						Golgi to secretory granule transport|neuron projection development	centrosome	dynactin binding|Rab GTPase binding			ovary(2)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)																	---	---	---	---
RNF10	9921	broad.mit.edu	37	12	120990230	120990230	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:120990230delT	uc001typ.3	+						RNF10_uc010szk.1_Intron|RNF10_uc001tyq.3_Intron	NM_014868	NP_055683			ring finger protein 10						negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)																	---	---	---	---
HNF1A	6927	broad.mit.edu	37	12	121432115	121432115	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:121432115delG	uc001tzg.2	+	4	885	c.862delG	c.(862-864)GGGfs	p.G288fs	HNF1A_uc001tze.1_Frame_Shift_Del_p.G288fs|HNF1A_uc001tzf.2_Frame_Shift_Del_p.G288fs|HNF1A_uc010szn.1_Frame_Shift_Del_p.G288fs	NM_000545	NP_000536	P20823	HNF1A_HUMAN	hepatic nuclear factor-1-alpha	288					glucose homeostasis|glucose import|insulin secretion|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|renal glucose absorption	cytoplasm|nucleus|protein complex	DNA binding|protein dimerization activity|protein heterodimerization activity|protein homodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			liver(92)|large_intestine(15)|endometrium(6)|breast(2)|lung(1)	116	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)													Hepatic_Adenoma_Familial_Clustering_of				---	---	---	---
KDM2B	84678	broad.mit.edu	37	12	122018158	122018158	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:122018158delG	uc001uat.2	-						KDM2B_uc001uas.2_5'UTR|KDM2B_uc001uau.2_Intron|KDM2B_uc001uav.3_Intron	NM_032590	NP_115979			F-box and leucine-rich repeat protein 10 isoform						embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			ovary(1)|skin(1)	2																		---	---	---	---
HPD	3242	broad.mit.edu	37	12	122281717	122281718	+	Frame_Shift_Del	DEL	CT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:122281717_122281718delCT	uc001ubj.2	-	12	892_893	c.852_853delAG	c.(850-855)AGAGGCfs	p.R284fs	HPD_uc001ubk.2_Frame_Shift_Del_p.R245fs	NM_002150	NP_002141	P32754	HPPD_HUMAN	4-hydroxyphenylpyruvate dioxygenase	284_285					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	4-hydroxyphenylpyruvate dioxygenase activity|metal ion binding				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000105)|Epithelial(86;0.000352)|BRCA - Breast invasive adenocarcinoma(302;0.225)	Nitisinone(DB00348)													---	---	---	---
WDR66	144406	broad.mit.edu	37	12	122437595	122437595	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:122437595delT	uc009zxk.2	+							NM_144668	NP_653269			WD repeat domain 66								calcium ion binding			ovary(1)|skin(1)	2	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)														---	---	---	---
WDR66	144406	broad.mit.edu	37	12	122439289	122439289	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:122439289delA	uc009zxk.2	+							NM_144668	NP_653269			WD repeat domain 66								calcium ion binding			ovary(1)|skin(1)	2	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)														---	---	---	---
VPS33A	65082	broad.mit.edu	37	12	122716609	122716609	+	3'UTR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:122716609delA	uc001ucd.2	-	13					VPS33A_uc001ucc.2_Intron	NM_022916	NP_075067			vacuolar protein sorting 33A						lysosome localization|melanosome localization|platelet formation|protein transport|regulation of developmental pigmentation|vesicle docking involved in exocytosis	early endosome|late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			skin(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000336)|Epithelial(86;0.000606)|BRCA - Breast invasive adenocarcinoma(302;0.23)														---	---	---	---
RSRC2	65117	broad.mit.edu	37	12	123003697	123003697	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:123003697delA	uc001ucr.2	-						RSRC2_uc001uco.2_Intron|RSRC2_uc001ucp.2_Intron|RSRC2_uc001ucq.2_Intron|RSRC2_uc001ucs.2_Intron|RSRC2_uc001uct.2_Intron|RSRC2_uc001ucu.2_Intron	NM_023012	NP_075388			arginine/serine-rich coiled-coil 2 isoform a											ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.14e-05)|Epithelial(86;0.000183)|BRCA - Breast invasive adenocarcinoma(302;0.201)														---	---	---	---
KNTC1	9735	broad.mit.edu	37	12	123073397	123073397	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:123073397delT	uc001ucv.2	+						KNTC1_uc010taf.1_Intron	NM_014708	NP_055523			Rough Deal homolog, centromere/kinetochore						cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)														---	---	---	---
VPS37B	79720	broad.mit.edu	37	12	123351892	123351892	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:123351892delG	uc001udl.2	-	4	732	c.629delC	c.(628-630)CCAfs	p.P210fs		NM_024667	NP_078943	Q9H9H4	VP37B_HUMAN	vacuolar protein sorting 37B	210	Pro-rich.				cellular membrane organization|endosome transport|protein transport	late endosome membrane					0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.08e-05)|Epithelial(86;0.000197)|BRCA - Breast invasive adenocarcinoma(302;0.205)														---	---	---	---
MPHOSPH9	10198	broad.mit.edu	37	12	123682911	123682911	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:123682911delA	uc001uel.2	-						MPHOSPH9_uc010tal.1_Intron|MPHOSPH9_uc010tam.1_Intron|MPHOSPH9_uc001uem.2_Intron	NM_022782	NP_073619			M-phase phosphoprotein 9						M phase of mitotic cell cycle	centriole|Golgi membrane					0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000182)|Epithelial(86;0.00046)|BRCA - Breast invasive adenocarcinoma(302;0.169)														---	---	---	---
SBNO1	55206	broad.mit.edu	37	12	123794232	123794233	+	Intron	INS	-	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:123794232_123794233insG	uc010tap.1	-						SBNO1_uc009zxv.2_Intron|SBNO1_uc010tao.1_Intron|SBNO1_uc010taq.1_Intron|SBNO1_uc001ues.1_Intron	NM_018183	NP_060653			sno, strawberry notch homolog 1								ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)														---	---	---	---
SBNO1	55206	broad.mit.edu	37	12	123832759	123832759	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:123832759delA	uc010tap.1	-						SBNO1_uc010tao.1_Intron|SBNO1_uc010taq.1_Intron|SBNO1_uc001uet.2_Intron|SBNO1_uc001ueu.2_Intron|SBNO1_uc001uev.2_Intron|SBNO1_uc009zxy.1_Intron	NM_018183	NP_060653			sno, strawberry notch homolog 1								ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)														---	---	---	---
DNAH10	196385	broad.mit.edu	37	12	124358317	124358318	+	Intron	DEL	GT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:124358317_124358318delGT	uc001uft.3	+							NM_207437	NP_997320			dynein, axonemal, heavy chain 10						microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)														---	---	---	---
TMEM132B	114795	broad.mit.edu	37	12	126075567	126075568	+	Intron	DEL	GT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:126075567_126075568delGT	uc001uhe.1	+							NM_052907	NP_443139			transmembrane protein 132B							integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)														---	---	---	---
Unknown	0	broad.mit.edu	37	12	127562381	127562381	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:127562381delT								LOC100128554 (605051 upstream) : None (None downstream)																																			---	---	---	---
ULK1	8408	broad.mit.edu	37	12	132406103	132406103	+	3'UTR	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:132406103delG	uc001uje.2	+	28						NM_003565	NP_003556			Unc-51-like kinase 1						autophagy|protein localization|regulation of autophagy	autophagic vacuole|cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	ATP binding|protein complex binding|protein serine/threonine kinase activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.07e-08)|Epithelial(86;2.56e-07)|all cancers(50;3.01e-07)														---	---	---	---
NOC4L	79050	broad.mit.edu	37	12	132632002	132632002	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:132632002delG	uc001ujz.1	+							NM_024078	NP_076983			nucleolar complex associated 4 homolog						rRNA processing	integral to membrane|nuclear membrane|nucleolus	protein binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.2e-08)|Epithelial(86;3.34e-07)|all cancers(50;1.97e-05)														---	---	---	---
Unknown	0	broad.mit.edu	37	12	133702170	133702170	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:133702170delA								ZNF140 (17914 upstream) : ZNF10 (5043 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	13	19761247	19761247	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:19761247delT								TUBA3C (5311 upstream) : LOC100101938 (75694 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	13	19801216	19801216	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:19801216delT								TUBA3C (45280 upstream) : LOC100101938 (35725 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	13	19943478	19943478	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:19943478delA								LOC100101938 (24365 upstream) : TPTE2 (53543 downstream)																																			---	---	---	---
XPO4	64328	broad.mit.edu	37	13	21359809	21359809	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:21359809delA	uc001unq.3	-							NM_022459	NP_071904			exportin 4						protein transport	cytoplasm|nucleus	protein binding			large_intestine(1)|ovary(1)|kidney(1)	3		all_cancers(29;5.05e-24)|all_epithelial(30;5.56e-20)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000521)|Epithelial(112;0.000892)|OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Lung(94;0.0189)|LUSC - Lung squamous cell carcinoma(192;0.0548)														---	---	---	---
XPO4	64328	broad.mit.edu	37	13	21359921	21359922	+	Intron	DEL	GA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:21359921_21359922delGA	uc001unq.3	-							NM_022459	NP_071904			exportin 4						protein transport	cytoplasm|nucleus	protein binding			large_intestine(1)|ovary(1)|kidney(1)	3		all_cancers(29;5.05e-24)|all_epithelial(30;5.56e-20)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000521)|Epithelial(112;0.000892)|OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Lung(94;0.0189)|LUSC - Lung squamous cell carcinoma(192;0.0548)														---	---	---	---
XPO4	64328	broad.mit.edu	37	13	21436786	21436786	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:21436786delA	uc001unq.3	-						XPO4_uc010tcr.1_Intron	NM_022459	NP_071904			exportin 4						protein transport	cytoplasm|nucleus	protein binding			large_intestine(1)|ovary(1)|kidney(1)	3		all_cancers(29;5.05e-24)|all_epithelial(30;5.56e-20)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000521)|Epithelial(112;0.000892)|OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Lung(94;0.0189)|LUSC - Lung squamous cell carcinoma(192;0.0548)														---	---	---	---
Unknown	0	broad.mit.edu	37	13	21523421	21523422	+	IGR	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:21523421_21523422insT								XPO4 (46508 upstream) : LATS2 (23756 downstream)																																			---	---	---	---
LATS2	26524	broad.mit.edu	37	13	21557175	21557175	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:21557175delA	uc009zzs.2	-						LATS2_uc001unr.3_Intron	NM_014572	NP_055387			LATS, large tumor suppressor, homolog 2						cell division|G1/S transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|central_nervous_system(3)|ovary(2)|breast(1)|pancreas(1)	10		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)														---	---	---	---
TNFRSF19	55504	broad.mit.edu	37	13	24164483	24164484	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:24164483_24164484insT	uc001uov.1	+						TNFRSF19_uc001uot.2_Intron|TNFRSF19_uc010tcu.1_Intron|TNFRSF19_uc001uow.2_Intron|TNFRSF19_uc001uou.2_Intron	NM_018647	NP_061117			tumor necrosis factor receptor superfamily,						apoptosis|induction of apoptosis|JNK cascade	integral to membrane|mitochondrion	tumor necrosis factor receptor activity			kidney(1)|skin(1)	2		all_cancers(29;3.4e-22)|all_epithelial(30;8.75e-19)|all_lung(29;5.09e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00193)|Epithelial(112;0.0137)|OV - Ovarian serous cystadenocarcinoma(117;0.0465)|GBM - Glioblastoma multiforme(144;0.184)|Lung(94;0.19)														---	---	---	---
PARP4	143	broad.mit.edu	37	13	25030500	25030500	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:25030500delT	uc001upl.2	-	21	2647	c.2541delA	c.(2539-2541)AAAfs	p.K847fs	PARP4_uc010tdc.1_Frame_Shift_Del_p.K847fs	NM_006437	NP_006428	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	847					cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			ovary(3)|skin(1)	4		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)														---	---	---	---
ATP8A2	51761	broad.mit.edu	37	13	26114438	26114438	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:26114438delT	uc001uqk.2	+						ATP8A2_uc010tdi.1_Intron|ATP8A2_uc010tdj.1_Intron|ATP8A2_uc001uql.1_Intron	NM_016529	NP_057613			ATPase, aminophospholipid transporter-like,						ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)														---	---	---	---
ATP8A2	51761	broad.mit.edu	37	13	26133701	26133701	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:26133701delA	uc001uqk.2	+						ATP8A2_uc010tdi.1_Intron|ATP8A2_uc010tdj.1_Intron|ATP8A2_uc001uql.1_Intron	NM_016529	NP_057613			ATPase, aminophospholipid transporter-like,						ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)														---	---	---	---
POLR1D	51082	broad.mit.edu	37	13	28240241	28240241	+	3'UTR	DEL	A	-	-	rs71698623		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:28240241delA	uc001urp.2	+	3					POLR1D_uc010aam.2_3'UTR|POLR1D_uc001urq.2_RNA	NM_152705	NP_689918			polymerase (RNA) I polypeptide D isoform 2						termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein dimerization activity				0		Lung SC(185;0.0161)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	all cancers(112;0.0758)|OV - Ovarian serous cystadenocarcinoma(117;0.1)|Epithelial(112;0.213)														---	---	---	---
FLT3	2322	broad.mit.edu	37	13	28601359	28601359	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:28601359delA	uc001urw.2	-	17	2155	c.2073delT	c.(2071-2073)TTTfs	p.F691fs	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Frame_Shift_Del_p.F691fs	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	691	Protein kinase.|Cytoplasmic (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)			Mis|O		AML|ALL								---	---	---	---
KATNAL1	84056	broad.mit.edu	37	13	30782950	30782951	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:30782950_30782951insA	uc001uss.2	-						KATNAL1_uc001ust.2_Intron	NM_001014380	NP_001014402			katanin p60 subunit A-like 1							cytoplasm|microtubule	ATP binding|microtubule-severing ATPase activity				0		Lung SC(185;0.0257)		all cancers(112;0.114)|OV - Ovarian serous cystadenocarcinoma(117;0.213)														---	---	---	---
KATNAL1	84056	broad.mit.edu	37	13	30784427	30784427	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:30784427delA	uc001uss.2	-						KATNAL1_uc001ust.2_Intron	NM_001014380	NP_001014402			katanin p60 subunit A-like 1							cytoplasm|microtubule	ATP binding|microtubule-severing ATPase activity				0		Lung SC(185;0.0257)		all cancers(112;0.114)|OV - Ovarian serous cystadenocarcinoma(117;0.213)														---	---	---	---
FRY	10129	broad.mit.edu	37	13	32753208	32753208	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:32753208delT	uc001utx.2	+						FRY_uc010tdw.1_Intron	NM_023037	NP_075463			furry homolog						regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)														---	---	---	---
FRY	10129	broad.mit.edu	37	13	32868490	32868490	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:32868490delT	uc001utx.2	+						FRY_uc010tdw.1_Intron|FRY_uc001utz.2_Intron|FRY_uc010tdx.1_Intron	NM_023037	NP_075463			furry homolog						regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)														---	---	---	---
PDS5B	23047	broad.mit.edu	37	13	33315189	33315190	+	Intron	DEL	GT	-	-	rs2320470		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:33315189_33315190delGT	uc010abf.2	+						PDS5B_uc010abg.2_Intron	NM_015032	NP_055847			PDS5, regulator of cohesion maintenance, homolog						cell division|cell proliferation|mitotic sister chromatid cohesion|negative regulation of cell proliferation	chromatin|nucleus	ATP binding|DNA binding|identical protein binding			ovary(2)|lung(1)|pancreas(1)	4		Lung SC(185;0.0367)		all cancers(112;5.55e-06)|Epithelial(112;2.7e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00303)|BRCA - Breast invasive adenocarcinoma(63;0.0204)														---	---	---	---
STARD13	90627	broad.mit.edu	37	13	33752098	33752099	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:33752098_33752099insA	uc001uuw.2	-						STARD13_uc001uuu.2_Intron|STARD13_uc001uuv.2_Intron|STARD13_uc001uux.2_Intron|STARD13_uc010tec.1_Intron|STARD13_uc010abh.1_Intron	NM_178006	NP_821074			StAR-related lipid transfer (START) domain						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)														---	---	---	---
C13orf36	400120	broad.mit.edu	37	13	37269030	37269030	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:37269030delT	uc001uvt.3	+							NM_203451	NP_982276			hypothetical protein LOC400120							integral to membrane				skin(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	13	38541489	38541490	+	IGR	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:38541489_38541490delTT								TRPC4 (97550 upstream) : UFM1 (382452 downstream)																																			---	---	---	---
COG6	57511	broad.mit.edu	37	13	40301747	40301747	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:40301747delT	uc001uxh.2	+						COG6_uc001uxi.2_Intron|COG6_uc010acb.2_Intron	NM_020751	NP_065802			component of oligomeric golgi complex 6 isoform						protein transport	Golgi membrane|Golgi transport complex				kidney(1)|skin(1)	2		Lung NSC(96;0.000124)|Breast(139;0.0199)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.03e-09)|Epithelial(112;7e-07)|OV - Ovarian serous cystadenocarcinoma(117;0.00015)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.0168)														---	---	---	---
MRPS31	10240	broad.mit.edu	37	13	41323144	41323144	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:41323144delT	uc001uxm.3	-							NM_005830	NP_005821			mitochondrial ribosomal protein S31 precursor							mitochondrion|ribosome	protein domain specific binding				0		Lung NSC(96;3.55e-06)|Breast(139;0.00394)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(188;0.194)		all cancers(112;1.52e-08)|Epithelial(112;7.63e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000192)|GBM - Glioblastoma multiforme(144;0.00233)|BRCA - Breast invasive adenocarcinoma(63;0.0706)														---	---	---	---
MTRF1	9617	broad.mit.edu	37	13	41826691	41826691	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:41826691delA	uc001uxx.2	-						MTRF1_uc001uxy.2_Intron|MTRF1_uc001uxz.2_Intron|MTRF1_uc010tff.1_Intron|MTRF1_uc001uyc.1_Intron	NM_004294	NP_004285			mitochondrial translational release factor 1						regulation of translational termination	mitochondrion	translation release factor activity, codon specific				0		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)|Ovarian(182;0.125)		OV - Ovarian serous cystadenocarcinoma(117;4.24e-10)|all cancers(112;2.05e-09)|Epithelial(112;2.48e-09)|GBM - Glioblastoma multiforme(144;0.00115)|BRCA - Breast invasive adenocarcinoma(63;0.0721)|KIRC - Kidney renal clear cell carcinoma(186;0.248)														---	---	---	---
KIAA0564	23078	broad.mit.edu	37	13	42293886	42293886	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:42293886delA	uc001uyj.2	-						KIAA0564_uc001uyk.2_Intron	NM_015058	NP_055873			hypothetical protein LOC23078 isoform a							extracellular region	ATP binding|ATPase activity			ovary(3)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	6		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)														---	---	---	---
AKAP11	11215	broad.mit.edu	37	13	42882563	42882563	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:42882563delT	uc001uys.1	+							NM_016248	NP_057332			A-kinase anchor protein 11						intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)														---	---	---	---
ENOX1	55068	broad.mit.edu	37	13	43986300	43986300	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:43986300delA	uc001uza.3	-						ENOX1_uc001uzb.3_Intron|ENOX1_uc001uzc.3_Intron	NM_001127615	NP_001121087			ecto-NOX disulfide-thiol exchanger 1						electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			pancreas(1)|skin(1)	2		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)														---	---	---	---
TSC22D1	8848	broad.mit.edu	37	13	45090339	45090339	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:45090339delA	uc001uzn.3	-						TSC22D1_uc001uzo.1_Intron	NM_183422	NP_904358			TSC22 domain family, member 1 isoform 1						transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity				0		all_hematologic(4;8.74e-08)|Acute lymphoblastic leukemia(4;1.78e-07)|Lung NSC(96;2.21e-05)|Breast(139;0.000625)|Prostate(109;0.000947)|Hepatocellular(98;0.0202)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;0.000522)|BRCA - Breast invasive adenocarcinoma(63;0.118)														---	---	---	---
Unknown	0	broad.mit.edu	37	13	46014351	46014352	+	IGR	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:46014351_46014352delAA								SLC25A30 (21835 upstream) : COG3 (24719 downstream)																																			---	---	---	---
ZC3H13	23091	broad.mit.edu	37	13	46543397	46543398	+	Frame_Shift_Ins	INS	-	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:46543397_46543398insG	uc010tfw.1	-	13	3287_3288	c.3281_3282insC	c.(3280-3282)CCTfs	p.P1094fs	ZC3H13_uc001vaq.2_5'Flank|ZC3H13_uc001vas.1_Frame_Shift_Ins_p.P1094fs|ZC3H13_uc001vat.1_Frame_Shift_Ins_p.P1094fs	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	1094							nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)														---	---	---	---
ZC3H13	23091	broad.mit.edu	37	13	46577338	46577338	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:46577338delT	uc010tfw.1	-	7	886	c.880delA	c.(880-882)ACAfs	p.T294fs	ZC3H13_uc001vas.1_Frame_Shift_Del_p.T294fs|ZC3H13_uc001vat.1_Frame_Shift_Del_p.T294fs	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	294							nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)														---	---	---	---
ESD	2098	broad.mit.edu	37	13	47361063	47361063	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:47361063delA	uc001vbn.2	-						ESD_uc001vbo.2_Intron	NM_001984	NP_001975			esterase D/formylglutathione hydrolase							cytoplasmic membrane-bounded vesicle	carboxylesterase activity|S-formylglutathione hydrolase activity			ovary(1)	1		all_lung(13;3.54e-08)|Lung NSC(96;9.1e-06)|Breast(56;0.000148)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)		GBM - Glioblastoma multiforme(144;2.66e-05)	Glutathione(DB00143)													---	---	---	---
RCBTB1	55213	broad.mit.edu	37	13	50108433	50108433	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:50108433delT	uc001vde.1	-							NM_018191	NP_060661			regulator of chromosome condensation (RCC1) and						cell cycle|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(1)	1		Lung NSC(96;2.1e-05)|Breast(56;0.00015)|Prostate(109;0.00314)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;4.7e-09)														---	---	---	---
INTS6	26512	broad.mit.edu	37	13	52026040	52026040	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:52026040delG	uc001vfk.2	-						INTS6_uc001vfj.2_Intron|INTS6_uc001vfl.2_Intron|INTS6_uc001vfm.2_Intron|uc001vfn.2_5'Flank	NM_012141	NP_036273			integrator complex subunit 6 isoform a						snRNA processing	actin cytoskeleton|integrator complex	protein binding|transmembrane receptor activity			ovary(1)|lung(1)	2		Breast(56;0.000286)|Lung NSC(96;0.00145)|Prostate(109;0.00403)|Hepatocellular(98;0.065)|Myeloproliferative disorder(33;0.163)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;7.7e-08)														---	---	---	---
DHRS12	79758	broad.mit.edu	37	13	52364073	52364073	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:52364073delT	uc001vfq.2	-						DHRS12_uc001vfr.1_Intron|DHRS12_uc001vfs.1_Intron					RecName: Full=Dehydrogenase/reductase SDR family member 12;          EC=1.1.-.-;								binding|oxidoreductase activity				0		Breast(56;0.00173)|Prostate(109;0.00899)|Lung NSC(96;0.0199)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.81e-08)														---	---	---	---
THSD1P1	374500	broad.mit.edu	37	13	52764065	52764065	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:52764065delA	uc001vgk.2	-						THSD1P1_uc001vgm.1_Intron|THSD1P1_uc010adx.1_Intron|THSD1P1_uc010ady.1_Intron|THSD1P1_uc001vgl.1_RNA					Homo sapiens cDNA FLJ14630 fis, clone NT2RP2000459.												0																		---	---	---	---
VPS36	51028	broad.mit.edu	37	13	52999942	52999942	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:52999942delA	uc001vgs.2	-						VPS36_uc001vgq.2_Intron	NM_016075	NP_057159			vacuolar protein sorting 36						cellular membrane organization|endosome transport|protein transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|late endosome|membrane|nucleus	lipid binding			skin(1)	1		Breast(56;0.000207)|Lung NSC(96;0.00212)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.14e-08)														---	---	---	---
DACH1	1602	broad.mit.edu	37	13	72049399	72049399	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:72049399delA	uc010thn.1	-						DACH1_uc010tho.1_Intron|DACH1_uc010thp.1_Intron	NM_080759	NP_542937			dachshund homolog 1 isoform a						multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			breast(1)	1		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)														---	---	---	---
KLF5	688	broad.mit.edu	37	13	73650112	73650112	+	3'UTR	DEL	C	-	-	rs9573097	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:73650112delC	uc001vje.2	+	4					KLF5_uc001vjd.2_3'UTR	NM_001730	NP_001721			Kruppel-like factor 5						transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|pancreas(1)	3		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)														---	---	---	---
TBC1D4	9882	broad.mit.edu	37	13	75863376	75863376	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:75863376delA	uc001vjl.1	-						TBC1D4_uc010tht.1_Intron|TBC1D4_uc010thu.1_Intron|TBC1D4_uc010aer.2_Intron|TBC1D4_uc010aes.2_Intron	NM_014832	NP_055647			TBC1 domain family, member 4							cytoplasm	Rab GTPase activator activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)														---	---	---	---
TBC1D4	9882	broad.mit.edu	37	13	75901807	75901807	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:75901807delA	uc001vjl.1	-						TBC1D4_uc010aer.2_Intron|TBC1D4_uc010aes.2_Intron	NM_014832	NP_055647			TBC1 domain family, member 4							cytoplasm	Rab GTPase activator activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)														---	---	---	---
TBC1D4	9882	broad.mit.edu	37	13	75910884	75910885	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:75910884_75910885insA	uc001vjl.1	-						TBC1D4_uc010aer.2_Intron|TBC1D4_uc010aes.2_Intron	NM_014832	NP_055647			TBC1 domain family, member 4							cytoplasm	Rab GTPase activator activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)														---	---	---	---
LMO7	4008	broad.mit.edu	37	13	76210945	76210946	+	Intron	DEL	CT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:76210945_76210946delCT	uc010thv.1	+						LMO7_uc001vjt.1_Intron	NM_005358	NP_005349			LIM domain only 7 isoform 1							cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)|prostate(1)|skin(1)	5		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)														---	---	---	---
MYCBP2	23077	broad.mit.edu	37	13	77743708	77743708	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:77743708delT	uc001vkf.2	-						MYCBP2_uc010aev.2_Intron	NM_015057	NP_055872			MYC binding protein 2						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)														---	---	---	---
MYCBP2	23077	broad.mit.edu	37	13	77765900	77765900	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:77765900delC	uc001vkf.2	-	29	3961	c.3870delG	c.(3868-3870)GGGfs	p.G1290fs	MYCBP2_uc010aev.2_Frame_Shift_Del_p.G694fs	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	1290					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)														---	---	---	---
MYCBP2	23077	broad.mit.edu	37	13	77834802	77834802	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:77834802delA	uc001vkf.2	-						MYCBP2_uc010aev.2_Intron	NM_015057	NP_055872			MYC binding protein 2						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)														---	---	---	---
EDNRB	1910	broad.mit.edu	37	13	78477273	78477273	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:78477273delA	uc001vko.2	-						EDNRB_uc001vkq.1_Intron|uc001vkn.1_Intron|EDNRB_uc010aez.1_Intron|EDNRB_uc001vkp.1_Intron	NM_001122659	NP_001116131			endothelin receptor type B isoform 1 precursor						activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|enteric nervous system development|enteric smooth muscle cell differentiation|macrophage chemotaxis|negative regulation of adenylate cyclase activity|negative regulation of cellular protein metabolic process|negative regulation of neuron maturation|negative regulation of transcription from RNA polymerase II promoter|vein smooth muscle contraction	integral to plasma membrane	endothelin-B receptor activity|peptide hormone binding				0		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0933)	Bosentan(DB00559)													---	---	---	---
RBM26	64062	broad.mit.edu	37	13	79940022	79940022	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:79940022delT	uc001vkz.2	-						RBM26_uc001vky.2_Intron|RBM26_uc001vla.2_Intron|RBM26_uc001vkx.2_Intron	NM_022118	NP_071401			RNA binding motif protein 26						mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)														---	---	---	---
NDFIP2	54602	broad.mit.edu	37	13	80122252	80122252	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:80122252delT	uc001vlf.2	+						NDFIP2_uc010tib.1_Intron|NDFIP2_uc001vlg.2_Intron	NM_019080	NP_061953			Nedd4 family interacting protein 2 isoform 1						negative regulation of gene expression|negative regulation of protein transport|negative regulation of transporter activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of protein ubiquitination	endoplasmic reticulum|Golgi membrane|integral to membrane|mitochondrion|multivesicular body membrane|perinuclear region of cytoplasm	signal transducer activity|WW domain binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.205)		GBM - Glioblastoma multiforme(99;0.0196)														---	---	---	---
Unknown	0	broad.mit.edu	37	13	82265134	82265134	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:82265134delT								None (None upstream) : None (None downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	13	83894251	83894251	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:83894251delA								None (None upstream) : SLITRK1 (557093 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	13	90902014	90902025	+	IGR	DEL	GAAGGAAGGAAG	-	-	rs143996596	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:90902014_90902025delGAAGGAAGGAAG								MIR622 (18483 upstream) : LOC144776 (641183 downstream)																																			---	---	---	---
GPC6	10082	broad.mit.edu	37	13	94197839	94197840	+	Intron	DEL	TT	-	-	rs34963201		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:94197839_94197840delTT	uc001vlt.2	+						GPC6_uc010tig.1_Intron|GPC6_uc001vlu.1_Intron	NM_005708	NP_005699			glypican 6 precursor							anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)																---	---	---	---
TGDS	23483	broad.mit.edu	37	13	95243093	95243093	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:95243093delA	uc001vlw.2	-						TGDS_uc001vlx.2_Intron	NM_014305	NP_055120			TDP-glucose 4,6-dehydratase						cellular metabolic process		coenzyme binding|dTDP-glucose 4,6-dehydratase activity|protein binding				0	all_neural(89;0.0684)|Medulloblastoma(90;0.163)																	---	---	---	---
GPR180	160897	broad.mit.edu	37	13	95273242	95273243	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:95273242_95273243delAA	uc001vly.2	+						GPR180_uc001vlz.2_Intron|GPR180_uc010afi.2_Intron	NM_180989	NP_851320			G protein-coupled receptor 180 precursor							integral to membrane				breast(1)	1	all_neural(89;0.0684)|Medulloblastoma(90;0.163)																	---	---	---	---
ABCC4	10257	broad.mit.edu	37	13	95862712	95862712	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:95862712delA	uc001vmd.3	-						ABCC4_uc010afk.2_Intron|ABCC4_uc001vme.2_Intron|ABCC4_uc010tih.1_Intron|ABCC4_uc001vmf.2_Intron|ABCC4_uc010afl.1_Intron|ABCC4_uc010afm.1_Intron	NM_005845	NP_005836			ATP-binding cassette, sub-family C, member 4						platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			central_nervous_system(3)|skin(1)	4	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)													---	---	---	---
UGGT2	55757	broad.mit.edu	37	13	96579593	96579593	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:96579593delA	uc001vmt.2	-							NM_020121	NP_064506			UDP-glucose ceramide glucosyltransferase-like 2						post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
DOCK9	23348	broad.mit.edu	37	13	99630097	99630097	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:99630097delG	uc001vnt.2	-						DOCK9_uc001vnw.2_Frame_Shift_Del_p.L23fs|DOCK9_uc001vnv.1_Intron|DOCK9_uc010tir.1_Intron|DOCK9_uc010tis.1_Frame_Shift_Del_p.L23fs|DOCK9_uc010tit.1_Intron	NM_015296	NP_056111			dedicator of cytokinesis 9 isoform a						blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)																	---	---	---	---
UBAC2	337867	broad.mit.edu	37	13	100020309	100020309	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:100020309delT	uc001voa.3	+						UBAC2_uc010tiu.1_Intron|UBAC2_uc001vob.3_Intron|UBAC2_uc010tiv.1_Intron|UBAC2_uc001vod.2_Intron|UBAC2_uc001voc.2_Intron|UBAC2_uc010tiw.1_Intron|UBAC2_uc001voh.2_Intron	NM_001144072	NP_001137544			UBA domain containing 2 isoform 1							integral to membrane				ovary(1)	1	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)																	---	---	---	---
TM9SF2	9375	broad.mit.edu	37	13	100196011	100196011	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:100196011delA	uc001voj.1	+						TM9SF2_uc010afz.1_Intron	NM_004800	NP_004791			transmembrane 9 superfamily member 2 precursor						transport	endosome membrane|integral to plasma membrane				ovary(1)	1	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.218)																	---	---	---	---
TPP2	7174	broad.mit.edu	37	13	103266436	103266436	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:103266436delT	uc001vpi.3	+							NM_003291	NP_003282			tripeptidyl peptidase II						proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)																	---	---	---	---
Unknown	0	broad.mit.edu	37	13	106297202	106297205	+	IGR	DEL	TTCC	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:106297202_106297205delTTCC								DAOA (153820 upstream) : EFNB2 (844893 downstream)																																			---	---	---	---
TNFSF13B	10673	broad.mit.edu	37	13	108955486	108955486	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:108955486delT	uc001vqr.2	+						TNFSF13B_uc010agj.2_Intron|TNFSF13B_uc001vqs.1_Intron	NM_006573	NP_006564			tumor necrosis factor superfamily, member 13b						cell proliferation|immune response|signal transduction	extracellular space|integral to membrane|plasma membrane|soluble fraction	cytokine activity|tumor necrosis factor receptor binding				0	all_lung(23;0.000396)|all_neural(89;0.00256)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00902)|Lung SC(71;0.104)		all cancers(43;0.184)|BRCA - Breast invasive adenocarcinoma(86;0.19)															---	---	---	---
Unknown	0	broad.mit.edu	37	13	110078785	110078788	+	IGR	DEL	TCCT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:110078785_110078788delTCCT								MYO16 (218430 upstream) : IRS2 (327398 downstream)																																			---	---	---	---
COL4A1	1282	broad.mit.edu	37	13	110861640	110861640	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:110861640delT	uc001vqw.3	-						COL4A1_uc010agl.2_Intron	NM_001845	NP_001836			alpha 1 type IV collagen preproprotein						angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)															---	---	---	---
ARHGEF7	8874	broad.mit.edu	37	13	111940880	111940881	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:111940880_111940881insT	uc001vrs.2	+						ARHGEF7_uc001vrr.2_Intron|ARHGEF7_uc001vrt.2_Intron|ARHGEF7_uc001vrv.3_Intron|ARHGEF7_uc001vrw.3_Intron|ARHGEF7_uc001vrx.3_Intron|ARHGEF7_uc010tjo.1_Intron|ARHGEF7_uc010tjp.1_Intron|ARHGEF7_uc001vry.1_Intron	NM_001113511	NP_001106983			PAK-interacting exchange factor beta isoform c						apoptosis|epidermal growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_lung(23;3.96e-05)|Lung NSC(43;0.00156)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.188)															---	---	---	---
ATP11A	23250	broad.mit.edu	37	13	113460329	113460329	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:113460329delA	uc001vsi.3	+						ATP11A_uc001vsj.3_Intron|ATP11A_uc001vsm.1_Intron	NM_015205	NP_056020			ATPase, class VI, type 11A isoform a						ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)																---	---	---	---
TFDP1	7027	broad.mit.edu	37	13	114294635	114294635	+	3'UTR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:114294635delT	uc001vtw.2	+	12					TFDP1_uc010tkd.1_3'UTR|TFDP1_uc010tke.1_3'UTR|TFDP1_uc001vty.3_3'UTR|TFDP1_uc001vtx.2_3'UTR	NM_007111	NP_009042			transcription factor Dp-1						cell proliferation|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|regulation of transcription from RNA polymerase II promoter	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			lung(4)|ovary(2)|skin(1)	7	Lung NSC(43;0.0113)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.132)|all_epithelial(44;0.0731)|all_lung(25;0.149)|Breast(118;0.153)	all cancers(43;0.0576)												TSP Lung(29;0.18)			---	---	---	---
GAS6	2621	broad.mit.edu	37	13	114537792	114537792	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:114537792delC	uc001vud.2	-						GAS6_uc001vug.2_5'Flank|GAS6_uc001vuf.2_Intron	NM_000820	NP_000811			growth arrest-specific 6 isoform 1 precursor						cell proliferation|leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|post-translational protein modification|proteolysis|regulation of growth	endoplasmic reticulum lumen|extracellular space|Golgi lumen|platelet alpha granule lumen	calcium ion binding|receptor agonist activity			central_nervous_system(4)	4	Lung NSC(43;0.00976)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0176)|all_epithelial(44;0.0104)|all_lung(25;0.0249)|Lung NSC(25;0.0908)|Breast(118;0.188)																---	---	---	---
Unknown	0	broad.mit.edu	37	14	21191414	21191415	+	IGR	DEL	CC	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:21191414_21191415delCC								RNASE4 (22657 upstream) : EDDM3A (8445 downstream)																																			---	---	---	---
RPGRIP1	57096	broad.mit.edu	37	14	21790312	21790312	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:21790312delT	uc001wag.2	+						RPGRIP1_uc001wah.2_Intron|RPGRIP1_uc001wai.2_Intron|RPGRIP1_uc001waj.1_Intron|RPGRIP1_uc001wak.2_Intron|RPGRIP1_uc010aim.2_Intron|RPGRIP1_uc001wal.2_Intron|RPGRIP1_uc001wam.2_5'Flank	NM_020366	NP_065099			retinitis pigmentosa GTPase regulator						response to stimulus|visual perception	cilium				ovary(4)|breast(2)|pancreas(1)	7	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)														---	---	---	---
Unknown	0	broad.mit.edu	37	14	22293607	22293607	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:22293607delA	uc010tmf.1	+						uc001wbw.2_5'Flank|uc010ais.1_5'Flank					SubName: Full=Putative uncharacterized protein ENSP00000374943;																														---	---	---	---
Unknown	0	broad.mit.edu	37	14	22409540	22409541	+	Intron	INS	-	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:22409540_22409541insC	uc001wbw.2	+						uc010tmg.1_Intron|uc010tmh.1_Intron|uc010aiv.1_Intron|uc010tmi.1_Intron|uc010tmj.1_Intron|uc010aja.1_Intron|uc010ajb.1_Intron|uc001wck.2_Intron					SubName: Full=Alpha-chain C region; Flags: Fragment;																														---	---	---	---
MMP14	4323	broad.mit.edu	37	14	23313406	23313406	+	Intron	DEL	A	-	-	rs33967775		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:23313406delA	uc001whc.2	+							NM_004995	NP_004986			matrix metalloproteinase 14 preproprotein							extracellular matrix|integral to plasma membrane|melanosome	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0	all_cancers(95;9.47e-05)			GBM - Glioblastoma multiforme(265;0.00551)														---	---	---	---
PSMB5	5693	broad.mit.edu	37	14	23502434	23502434	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:23502434delA	uc001wii.2	-						PSMB5_uc001wij.2_Intron|PSMB5_uc010tni.1_Intron	NM_002797	NP_002788			proteasome beta 5 subunit isoform 1						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus	protein binding|threonine-type endopeptidase activity			ovary(1)	1	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.0121)	Bortezomib(DB00188)													---	---	---	---
RABGGTA	5875	broad.mit.edu	37	14	24740265	24740266	+	Intron	INS	-	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:24740265_24740266insG	uc001wof.2	-						RABGGTA_uc001woe.2_5'Flank|RABGGTA_uc001wog.2_Intron|RABGGTA_uc001woh.2_Intron|RABGGTA_uc001woi.2_Intron	NM_004581	NP_004572			Rab geranylgeranyltransferase alpha						visual perception		Rab geranylgeranyltransferase activity|zinc ion binding				0				GBM - Glioblastoma multiforme(265;0.0184)														---	---	---	---
NYNRIN	57523	broad.mit.edu	37	14	24877215	24877215	+	Frame_Shift_Del	DEL	C	-	-	rs10148781	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:24877215delC	uc001wpf.3	+	3	657	c.339delC	c.(337-339)GGCfs	p.G113fs		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	113					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
G2E3	55632	broad.mit.edu	37	14	31074772	31074772	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:31074772delA	uc001wqk.2	+	11	1226	c.1072delA	c.(1072-1074)AAAfs	p.K358fs	G2E3_uc010tpe.1_Intron|G2E3_uc010tpf.1_Frame_Shift_Del_p.K312fs	NM_017769	NP_060239	Q7L622	G2E3_HUMAN	G2/M-phase specific E3 ubiquitin ligase	358					apoptosis|multicellular organismal development|protein modification process	Golgi apparatus|nucleolus	acid-amino acid ligase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3																		---	---	---	---
SCFD1	23256	broad.mit.edu	37	14	31122672	31122672	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:31122672delT	uc001wqm.1	+						SCFD1_uc001wqn.1_Intron|SCFD1_uc010tpg.1_Intron|SCFD1_uc010tph.1_Intron|SCFD1_uc010amf.1_Intron|SCFD1_uc010tpi.1_Intron|SCFD1_uc010amd.1_Intron|SCFD1_uc010ame.1_Intron	NM_016106	NP_057190			vesicle transport-related protein isoform a						post-Golgi vesicle-mediated transport|protein transport|regulation of ER to Golgi vesicle-mediated transport|response to toxin|retrograde vesicle-mediated transport, Golgi to ER|vesicle docking involved in exocytosis	cis-Golgi network|endoplasmic reticulum membrane|Golgi cisterna membrane|Golgi-associated vesicle|plasma membrane	syntaxin-5 binding				0	Hepatocellular(127;0.0877)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)	GBM - Glioblastoma multiforme(265;0.0181)														---	---	---	---
SCFD1	23256	broad.mit.edu	37	14	31175237	31175238	+	Intron	INS	-	T	T	rs150091343	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:31175237_31175238insT	uc001wqm.1	+						SCFD1_uc001wqn.1_Intron|SCFD1_uc010tpg.1_Intron|SCFD1_uc010tph.1_Intron|SCFD1_uc010amf.1_Intron|SCFD1_uc010tpi.1_Intron|SCFD1_uc010amd.1_Intron|SCFD1_uc010ame.1_Intron	NM_016106	NP_057190			vesicle transport-related protein isoform a						post-Golgi vesicle-mediated transport|protein transport|regulation of ER to Golgi vesicle-mediated transport|response to toxin|retrograde vesicle-mediated transport, Golgi to ER|vesicle docking involved in exocytosis	cis-Golgi network|endoplasmic reticulum membrane|Golgi cisterna membrane|Golgi-associated vesicle|plasma membrane	syntaxin-5 binding				0	Hepatocellular(127;0.0877)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)	GBM - Glioblastoma multiforme(265;0.0181)														---	---	---	---
SCFD1	23256	broad.mit.edu	37	14	31177400	31177400	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:31177400delT	uc001wqm.1	+						SCFD1_uc001wqn.1_Intron|SCFD1_uc010tpg.1_Intron|SCFD1_uc010tph.1_Intron|SCFD1_uc010amf.1_Intron|SCFD1_uc010tpi.1_Intron|SCFD1_uc010amd.1_Intron|SCFD1_uc010ame.1_Intron	NM_016106	NP_057190			vesicle transport-related protein isoform a						post-Golgi vesicle-mediated transport|protein transport|regulation of ER to Golgi vesicle-mediated transport|response to toxin|retrograde vesicle-mediated transport, Golgi to ER|vesicle docking involved in exocytosis	cis-Golgi network|endoplasmic reticulum membrane|Golgi cisterna membrane|Golgi-associated vesicle|plasma membrane	syntaxin-5 binding				0	Hepatocellular(127;0.0877)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)	GBM - Glioblastoma multiforme(265;0.0181)														---	---	---	---
ARHGAP5	394	broad.mit.edu	37	14	32562545	32562545	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:32562545delT	uc001wrl.2	+	2	2909	c.2670delT	c.(2668-2670)GATfs	p.D890fs	ARHGAP5_uc001wrm.2_Frame_Shift_Del_p.D890fs|ARHGAP5_uc001wrn.2_Frame_Shift_Del_p.D890fs|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	890					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)														---	---	---	---
ARHGAP5	394	broad.mit.edu	37	14	32562675	32562675	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:32562675delT	uc001wrl.2	+	2	3039	c.2800delT	c.(2800-2802)TTTfs	p.F934fs	ARHGAP5_uc001wrm.2_Frame_Shift_Del_p.F934fs|ARHGAP5_uc001wrn.2_Frame_Shift_Del_p.F934fs|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	934					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)														---	---	---	---
Unknown	0	broad.mit.edu	37	14	35163907	35163907	+	IGR	DEL	T	-	-	rs11627743	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:35163907delT								SNX6 (64541 upstream) : CFL2 (15681 downstream)																																			---	---	---	---
RALGAPA1	253959	broad.mit.edu	37	14	36244342	36244342	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:36244342delT	uc001wti.2	-						RALGAPA1_uc001wtj.2_Intron|RALGAPA1_uc010tpv.1_Intron|RALGAPA1_uc010tpw.1_Intron	NM_014990	NP_055805			Ral GTPase activating protein, alpha subunit 1						activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4																		---	---	---	---
MBIP	51562	broad.mit.edu	37	14	36770037	36770037	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:36770037delA	uc001wtm.2	-						MBIP_uc001wto.2_Intron|MBIP_uc010tpy.1_Intron|MBIP_uc001wtn.2_Intron	NM_016586	NP_057670			MAP3K12 binding inhibitory protein 1 isoform 1						histone H3 acetylation|inactivation of MAPK activity involved in osmosensory signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm|nucleolus	identical protein binding|protein kinase inhibitor activity				0	all_cancers(3;1.55e-52)|all_epithelial(1;2.69e-62)|Breast(36;0.0505)|Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)		Lung(8;1.28e-07)|LUAD - Lung adenocarcinoma(9;3e-07)|Epithelial(34;0.0303)|all cancers(34;0.0781)	GBM - Glioblastoma multiforme(112;0.0191)														---	---	---	---
MBIP	51562	broad.mit.edu	37	14	36777407	36777407	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:36777407delA	uc001wtm.2	-						MBIP_uc001wto.2_Intron|MBIP_uc010tpy.1_Intron|MBIP_uc001wtn.2_Intron	NM_016586	NP_057670			MAP3K12 binding inhibitory protein 1 isoform 1						histone H3 acetylation|inactivation of MAPK activity involved in osmosensory signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm|nucleolus	identical protein binding|protein kinase inhibitor activity				0	all_cancers(3;1.55e-52)|all_epithelial(1;2.69e-62)|Breast(36;0.0505)|Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)		Lung(8;1.28e-07)|LUAD - Lung adenocarcinoma(9;3e-07)|Epithelial(34;0.0303)|all cancers(34;0.0781)	GBM - Glioblastoma multiforme(112;0.0191)														---	---	---	---
SEC23A	10484	broad.mit.edu	37	14	39514288	39514289	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:39514288_39514289insT	uc001wup.1	-						SEC23A_uc010tqa.1_Intron|SEC23A_uc010tqb.1_Intron	NM_006364	NP_006355			SEC23-related protein A						COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|Golgi membrane|smooth endoplasmic reticulum membrane	protein binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5	Hepatocellular(127;0.213)		Lung(238;0.00047)|LUAD - Lung adenocarcinoma(48;0.000565)	GBM - Glioblastoma multiforme(112;0.0151)														---	---	---	---
SEC23A	10484	broad.mit.edu	37	14	39517726	39517726	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:39517726delC	uc001wup.1	-						SEC23A_uc010tqa.1_Intron|SEC23A_uc010tqb.1_Intron	NM_006364	NP_006355			SEC23-related protein A						COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|Golgi membrane|smooth endoplasmic reticulum membrane	protein binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5	Hepatocellular(127;0.213)		Lung(238;0.00047)|LUAD - Lung adenocarcinoma(48;0.000565)	GBM - Glioblastoma multiforme(112;0.0151)														---	---	---	---
SEC23A	10484	broad.mit.edu	37	14	39532705	39532705	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:39532705delA	uc001wup.1	-						SEC23A_uc010tqa.1_Intron|SEC23A_uc010tqb.1_Intron|SEC23A_uc010tqc.1_Intron	NM_006364	NP_006355			SEC23-related protein A						COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|Golgi membrane|smooth endoplasmic reticulum membrane	protein binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5	Hepatocellular(127;0.213)		Lung(238;0.00047)|LUAD - Lung adenocarcinoma(48;0.000565)	GBM - Glioblastoma multiforme(112;0.0151)														---	---	---	---
SEC23A	10484	broad.mit.edu	37	14	39560923	39560923	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:39560923delA	uc001wup.1	-						SEC23A_uc010tqa.1_Intron|SEC23A_uc010tqb.1_Intron|SEC23A_uc010tqc.1_5'Flank	NM_006364	NP_006355			SEC23-related protein A						COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|Golgi membrane|smooth endoplasmic reticulum membrane	protein binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5	Hepatocellular(127;0.213)		Lung(238;0.00047)|LUAD - Lung adenocarcinoma(48;0.000565)	GBM - Glioblastoma multiforme(112;0.0151)														---	---	---	---
CTAGE5	4253	broad.mit.edu	37	14	39734733	39734733	+	5'Flank	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:39734733delT	uc001wvg.3	+						CTAGE5_uc010tqe.1_Intron|CTAGE5_uc001wuz.3_Intron|CTAGE5_uc001wuy.3_Intron|CTAGE5_uc001wvb.3_5'Flank|CTAGE5_uc001wvc.3_5'Flank|CTAGE5_uc001wva.3_5'Flank|CTAGE5_uc001wve.1_5'Flank|CTAGE5_uc001wvh.3_5'Flank|CTAGE5_uc001wvf.3_5'Flank|CTAGE5_uc001wvi.3_5'Flank|CTAGE5_uc010amz.2_5'Flank	NM_005930	NP_005921			CTAGE family, member 5 isoform 1								enzyme activator activity|protein binding				0	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0475)														---	---	---	---
CTAGE5	4253	broad.mit.edu	37	14	39782401	39782401	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:39782401delT	uc001wvg.3	+						CTAGE5_uc010tqe.1_Intron|CTAGE5_uc001wuz.3_Intron|CTAGE5_uc001wuy.3_Intron|CTAGE5_uc001wvb.3_Intron|CTAGE5_uc001wvc.3_Intron|CTAGE5_uc001wva.3_Intron|CTAGE5_uc001wvh.3_Intron|CTAGE5_uc001wvf.3_Intron|CTAGE5_uc001wvi.3_Intron|CTAGE5_uc010amz.2_Intron|CTAGE5_uc001wvj.3_Intron	NM_005930	NP_005921			CTAGE family, member 5 isoform 1								enzyme activator activity|protein binding				0	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0475)														---	---	---	---
Unknown	0	broad.mit.edu	37	14	39855714	39855714	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:39855714delT								CTAGE5 (35319 upstream) : FBXO33 (11164 downstream)																																			---	---	---	---
LRFN5	145581	broad.mit.edu	37	14	42373617	42373618	+	3'UTR	INS	-	A	A	rs11539099		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:42373617_42373618insA	uc001wvm.2	+	6					LRFN5_uc010ana.2_3'UTR	NM_152447	NP_689660			leucine rich repeat and fibronectin type III							integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)											HNSCC(30;0.082)			---	---	---	---
Unknown	0	broad.mit.edu	37	14	44546597	44546597	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:44546597delT								None (None upstream) : FSCB (426758 downstream)																																			---	---	---	---
FAM179B	23116	broad.mit.edu	37	14	45540826	45540826	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:45540826delT	uc001wvv.2	+						FAM179B_uc001wvw.2_Intron|FAM179B_uc010anc.2_Intron	NM_015091	NP_055906			hypothetical protein LOC23116								binding			skin(2)|upper_aerodigestive_tract(1)	3																		---	---	---	---
SDCCAG1	9147	broad.mit.edu	37	14	50247296	50247296	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:50247296delA	uc010anj.1	-						KLHDC2_uc001wwx.2_Intron|KLHDC2_uc001wwy.2_Intron|KLHDC2_uc010anp.2_Intron	NM_004713	NP_004704			serologically defined colon cancer antigen 1							cytoplasm|nucleus					0	all_epithelial(31;0.000822)|Breast(41;0.0117)	all_lung(585;1.02e-05)		OV - Ovarian serous cystadenocarcinoma(311;5.99e-34)														---	---	---	---
ATL1	51062	broad.mit.edu	37	14	51088550	51088550	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:51088550delT	uc001wyf.3	+						ATL1_uc001wyd.3_Intron|ATL1_uc001wye.3_Intron	NM_015915	NP_056999			atlastin GTPase 1 isoform a						axonogenesis|cell death|endoplasmic reticulum organization|protein homooligomerization	axon|endoplasmic reticulum membrane|Golgi cis cisterna|Golgi membrane|integral to membrane|microsome	GTP binding|GTPase activity|identical protein binding			skin(3)|central_nervous_system(1)	4																		---	---	---	---
Unknown	0	broad.mit.edu	37	14	52755931	52755931	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:52755931delA								PTGDR (12490 upstream) : PTGER2 (25085 downstream)																																			---	---	---	---
TXNDC16	57544	broad.mit.edu	37	14	52957817	52957817	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:52957817delA	uc001wzs.2	-						TXNDC16_uc010tqu.1_Intron|TXNDC16_uc010aoe.2_Intron	NM_020784	NP_065835			thioredoxin domain containing 16 isoform 1						cell redox homeostasis	extracellular region					0	Breast(41;0.0716)																	---	---	---	---
BMP4	652	broad.mit.edu	37	14	54416700	54416701	+	3'UTR	DEL	GT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:54416700_54416701delGT	uc001xal.3	-	3					BMP4_uc010aoh.2_3'UTR|BMP4_uc001xao.3_3'UTR|BMP4_uc001xan.3_3'UTR	NM_130851	NP_570912			bone morphogenetic protein 4 preproprotein						activation of MAPKK activity|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|BMP signaling pathway involved in heart induction|BMP signaling pathway involved in nephric duct formation|branching involved in ureteric bud morphogenesis|bronchus development|bud dilation involved in lung branching|cardiac septum development|cartilage development|endocardial cushion development|epithelial cell proliferation involved in lung morphogenesis|intermediate mesodermal cell differentiation|lung alveolus development|lymphoid progenitor cell differentiation|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway|negative regulation of branching involved in ureteric bud morphogenesis|negative regulation of cell proliferation involved in heart morphogenesis|negative regulation of glomerular mesangial cell proliferation|negative regulation of glomerulus development|negative regulation of immature T cell proliferation in thymus|negative regulation of MAP kinase activity|negative regulation of metanephric comma-shaped body morphogenesis|negative regulation of metanephric S-shaped body morphogenesis|negative regulation of mitosis|negative regulation of myoblast differentiation|negative regulation of phosphorylation|negative regulation of striated muscle tissue development|negative regulation of thymocyte apoptosis|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cardiac muscle fiber development|positive regulation of cartilage development|positive regulation of collagen biosynthetic process|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of kidney development|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|protein localization to nucleus|pulmonary artery endothelial tube morphogenesis|secondary heart field specification|SMAD protein signal transduction|specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway|steroid hormone mediated signaling pathway	extracellular space|proteinaceous extracellular matrix	BMP receptor binding|chemoattractant activity|cytokine activity|growth factor activity				0																		---	---	---	---
CDKN3	1033	broad.mit.edu	37	14	54868069	54868070	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:54868069_54868070delTT	uc001xap.2	+						CDKN3_uc001xar.2_Intron|CDKN3_uc001xaq.2_Intron|CDKN3_uc010aoi.1_Intron|CDKN3_uc001xas.1_Intron|CDKN3_uc010aoj.1_Intron	NM_005192	NP_005183			cyclin-dependent kinase inhibitor 3 isoform 1						cell cycle arrest|G1/S transition of mitotic cell cycle|negative regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity	perinuclear region of cytoplasm	protein binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0																		---	---	---	---
GCH1	2643	broad.mit.edu	37	14	55310346	55310346	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:55310346delA	uc001xbh.1	-						GCH1_uc001xbi.1_3'UTR|GCH1_uc001xbj.1_Intron|GCH1_uc001xbk.1_Intron|GCH1_uc010aol.1_Intron	NM_001024024	NP_001019195			GTP cyclohydrolase 1 isoform 1						dopamine biosynthetic process|GTP catabolic process|neuromuscular process controlling posture|nitric oxide biosynthetic process|positive regulation of nitric-oxide synthase activity|protein homooligomerization|response to interferon-gamma|response to lipopolysaccharide|response to pain|response to tumor necrosis factor|tetrahydrobiopterin biosynthetic process|tetrahydrofolate biosynthetic process	cytoplasmic vesicle|cytosol|nuclear membrane|protein complex	GTP binding|GTP cyclohydrolase I activity|protein homodimerization activity|zinc ion binding			skin(1)	1																		---	---	---	---
KTN1	3895	broad.mit.edu	37	14	56103092	56103092	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:56103092delT	uc001xcb.2	+						KTN1_uc001xce.2_Intron|KTN1_uc001xcc.2_Intron|KTN1_uc001xcd.2_Intron|KTN1_uc010trb.1_Intron|KTN1_uc001xcf.1_Intron	NM_182926	NP_891556			kinectin 1 isoform a						microtubule-based movement	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction				breast(3)|ovary(2)|lung(1)|central_nervous_system(1)	7								T	RET	papillary thryoid								---	---	---	---
Unknown	0	broad.mit.edu	37	14	57150485	57150488	+	IGR	DEL	AAAA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:57150485_57150488delAAAA								C14orf101 (34255 upstream) : OTX2 (116939 downstream)																																			---	---	---	---
C14orf37	145407	broad.mit.edu	37	14	58604646	58604646	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:58604646delA	uc001xdc.2	-						C14orf37_uc010tro.1_Intron|C14orf37_uc001xdd.2_Intron|C14orf37_uc001xde.2_Intron	NM_001001872	NP_001001872			hypothetical protein LOC145407 precursor							integral to membrane	binding				0																		---	---	---	---
C14orf37	145407	broad.mit.edu	37	14	58675918	58675918	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:58675918delT	uc010tro.1	-						ACTR10_uc001xdf.2_Intron|ACTR10_uc001xdg.2_Intron|ACTR10_uc001xdh.2_Intron	NM_001001872	NP_001001872			hypothetical protein LOC145407 precursor							integral to membrane	binding				0																		---	---	---	---
C14orf37	145407	broad.mit.edu	37	14	58681823	58681823	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:58681823delA	uc010tro.1	-						ACTR10_uc001xdf.2_Intron|ACTR10_uc001xdg.2_Intron|ACTR10_uc001xdh.2_Intron|ACTR10_uc010trp.1_Intron|ACTR10_uc010apc.2_Intron	NM_001001872	NP_001001872			hypothetical protein LOC145407 precursor							integral to membrane	binding				0																		---	---	---	---
C14orf37	145407	broad.mit.edu	37	14	58727860	58727863	+	Intron	DEL	TTTT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:58727860_58727863delTTTT	uc010tro.1	-						PSMA3_uc001xdj.1_Intron|PSMA3_uc001xdk.1_Intron	NM_001001872	NP_001001872			hypothetical protein LOC145407 precursor							integral to membrane	binding				0																		---	---	---	---
KIAA0586	9786	broad.mit.edu	37	14	59014755	59014755	+	3'UTR	DEL	A	-	-	rs74607305		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:59014755delA	uc001xdv.3	+	30					KIAA0586_uc010trr.1_3'UTR|KIAA0586_uc001xdt.3_3'UTR|KIAA0586_uc001xdu.3_3'UTR|KIAA0586_uc010trs.1_3'UTR	NM_014749	NP_055564			talpid3 protein											ovary(1)	1																		---	---	---	---
RTN1	6252	broad.mit.edu	37	14	60097034	60097034	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:60097034delC	uc001xen.1	-						RTN1_uc001xem.1_Intron|RTN1_uc001xek.1_Intron|RTN1_uc001xel.1_Intron|RTN1_uc010apl.1_Intron	NM_021136	NP_066959			reticulon 1 isoform A						neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0968)														---	---	---	---
SIX4	51804	broad.mit.edu	37	14	61180924	61180924	+	Intron	DEL	A	-	-	rs35020088		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:61180924delA	uc001xfc.2	-							NM_017420	NP_059116			sine oculis homeobox homolog 4							nucleus				breast(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0275)														---	---	---	---
PPP2R5E	5529	broad.mit.edu	37	14	63920691	63920691	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:63920691delA	uc001xgd.1	-						PPP2R5E_uc010tsf.1_Intron|PPP2R5E_uc010tsg.1_Intron|PPP2R5E_uc001xge.2_Intron|PPP2R5E_uc010tsh.1_Intron|PPP2R5E_uc001xgf.1_Intron|PPP2R5E_uc001xgg.3_Intron	NM_006246	NP_006237			epsilon isoform of regulatory subunit B56,						signal transduction	cytoplasm|intracellular membrane-bounded organelle|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.00197)|all cancers(60;0.0153)|BRCA - Breast invasive adenocarcinoma(234;0.128)														---	---	---	---
ZBTB25	7597	broad.mit.edu	37	14	64953537	64953537	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:64953537delA	uc001xhc.2	-											Homo sapiens cDNA FLJ40862 fis, clone TRACH2018262, highly similar to Zinc finger and BTB domain-containing protein 25.							cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2				all cancers(60;0.00865)|OV - Ovarian serous cystadenocarcinoma(108;0.0102)|BRCA - Breast invasive adenocarcinoma(234;0.0469)														---	---	---	---
C14orf50	145376	broad.mit.edu	37	14	65019694	65019694	+	Intron	DEL	T	-	-	rs77325213		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:65019694delT	uc001xhl.1	+							NM_172365	NP_758953			hypothetical protein LOC145376											skin(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.00382)|all cancers(60;0.00427)|BRCA - Breast invasive adenocarcinoma(234;0.0488)														---	---	---	---
PLEKHG3	26030	broad.mit.edu	37	14	65197457	65197457	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:65197457delC	uc001xho.1	+						PLEKHG3_uc001xhn.1_Intron|PLEKHG3_uc001xhp.2_Intron|PLEKHG3_uc010aqh.1_Intron	NM_015549	NP_056364			pleckstrin homology domain containing, family G,						regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)	1				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)														---	---	---	---
ATP6V1D	51382	broad.mit.edu	37	14	67809927	67809927	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:67809927delT	uc001xjf.2	-						ATP6V1D_uc001xje.2_Intron	NM_015994	NP_057078			H(+)-transporting two-sector ATPase						ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|proton-transporting two-sector ATPase complex, catalytic domain|vacuolar proton-transporting V-type ATPase complex	protein binding|proton-transporting ATPase activity, rotational mechanism			ovary(1)|lung(1)	2				all cancers(60;0.000739)|OV - Ovarian serous cystadenocarcinoma(108;0.00597)|BRCA - Breast invasive adenocarcinoma(234;0.00957)														---	---	---	---
EIF2S1	1965	broad.mit.edu	37	14	67831815	67831816	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:67831815_67831816delAA	uc001xjg.2	+							NM_004094	NP_004085			eukaryotic translation initiation factor 2,							cytosol|eukaryotic translation initiation factor 2 complex|polysome|stress granule	protein binding|ribosome binding|translation initiation factor activity			ovary(1)	1				all cancers(60;0.000683)|OV - Ovarian serous cystadenocarcinoma(108;0.00579)|BRCA - Breast invasive adenocarcinoma(234;0.00937)														---	---	---	---
PCNX	22990	broad.mit.edu	37	14	71572271	71572272	+	Intron	DEL	TT	-	-	rs79334123		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:71572271_71572272delTT	uc001xmo.2	+						PCNX_uc010are.1_Intron|PCNX_uc010arf.1_Intron|PCNX_uc001xmp.2_Intron	NM_014982	NP_055797			pecanex-like 1							integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)														---	---	---	---
RBM25	58517	broad.mit.edu	37	14	73566524	73566524	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:73566524delA	uc001xno.2	+						RBM25_uc001xnn.3_Intron|RBM25_uc010ttu.1_Intron|RBM25_uc001xnp.2_Intron	NM_021239	NP_067062			RNA binding motif protein 25						apoptosis|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|RNA splicing	cytoplasm|nuclear speck	mRNA binding|nucleotide binding|protein binding			central_nervous_system(2)|ovary(1)|breast(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00362)|OV - Ovarian serous cystadenocarcinoma(108;0.0688)														---	---	---	---
DNAL1	83544	broad.mit.edu	37	14	74153808	74153808	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:74153808delA	uc001xoq.3	+						DNAL1_uc010aru.2_Intron|DNAL1_uc010arv.2_Intron	NM_031427	NP_113615			axonemal dynein light chain 1												0				BRCA - Breast invasive adenocarcinoma(234;0.00384)|KIRC - Kidney renal clear cell carcinoma(182;0.095)														---	---	---	---
KIAA0317	9870	broad.mit.edu	37	14	75131633	75131633	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:75131633delA	uc001xqb.2	-						KIAA0317_uc010tut.1_Intron	NM_001039479	NP_001034568			hypothetical protein LOC9870						protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane|intracellular	ubiquitin-protein ligase activity			ovary(2)|kidney(1)|central_nervous_system(1)|pancreas(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00404)														---	---	---	---
KIAA0317	9870	broad.mit.edu	37	14	75137987	75137987	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:75137987delT	uc001xqb.2	-						KIAA0317_uc010tut.1_Intron|KIAA0317_uc001xqc.2_Intron	NM_001039479	NP_001034568			hypothetical protein LOC9870						protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane|intracellular	ubiquitin-protein ligase activity			ovary(2)|kidney(1)|central_nervous_system(1)|pancreas(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00404)														---	---	---	---
TMED10	10972	broad.mit.edu	37	14	75601712	75601712	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:75601712delA	uc001xrm.1	-						TMED10_uc010ash.1_Intron|TMED10_uc010asg.1_Intron|TMED10_uc010tuz.1_Intron	NM_006827	NP_006818			transmembrane emp24 domain-containing protein 10						protein transport|regulated secretory pathway|vesicle targeting, to, from or within Golgi	cis-Golgi network|ER-Golgi intermediate compartment|Golgi membrane|integral to membrane|melanosome|microsome|zymogen granule membrane	protein binding				0				BRCA - Breast invasive adenocarcinoma(234;0.0126)														---	---	---	---
Unknown	0	broad.mit.edu	37	14	77352655	77352656	+	IGR	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:77352655_77352656delTT								C14orf166B (16010 upstream) : C14orf4 (138232 downstream)																																			---	---	---	---
DIO2	1734	broad.mit.edu	37	14	80669640	80669641	+	Intron	DEL	AA	-	-	rs72035234		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:80669640_80669641delAA	uc010tvq.1	-						DIO2_uc010tvp.1_Intron|DIO2_uc001xut.2_Intron|DIO2_uc010asx.2_Intron|DIO2_uc010tvr.1_Intron|DIO2_uc010asy.2_Intron	NM_000793	NP_000784			deiodinase, iodothyronine, type II isoform a						hormone biosynthetic process|selenocysteine incorporation|thyroid hormone generation	integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|ubiquitin protein ligase binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0281)														---	---	---	---
TSHR	7253	broad.mit.edu	37	14	81557384	81557384	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:81557384delT	uc001xvd.1	+						TSHR_uc001xvb.1_Intron|TSHR_uc001xvc.2_Intron|TSHR_uc010tvs.1_Intron	NM_000369	NP_000360			thyroid stimulating hormone receptor isoform 1						cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			thyroid(289)|ovary(5)|lung(3)|kidney(1)|skin(1)	299				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)			Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism 						---	---	---	---
Unknown	0	broad.mit.edu	37	14	88801396	88801397	+	IGR	INS	-	CT	CT			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:88801396_88801397insCT								KCNK10 (8140 upstream) : SPATA7 (50615 downstream)																																			---	---	---	---
SPATA7	55812	broad.mit.edu	37	14	88862579	88862579	+	Intron	DEL	A	-	-	rs149093540	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:88862579delA	uc001xwq.2	+						SPATA7_uc001xwr.2_Intron	NM_018418	NP_060888			spermatogenesis-associated protein 7 isoform a						response to stimulus|visual perception					ovary(1)	1																		---	---	---	---
CCDC88C	440193	broad.mit.edu	37	14	91810086	91810086	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:91810086delA	uc010aty.2	-						CCDC88C_uc010twk.1_Intron	NM_001080414	NP_001073883			DVL-binding protein DAPLE						microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			ovary(3)	3		all_cancers(154;0.0468)																---	---	---	---
TRIP11	9321	broad.mit.edu	37	14	92491852	92491853	+	Intron	INS	-	C	C	rs112570044		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:92491852_92491853insC	uc001xzy.2	-							NM_004239	NP_004230			thyroid hormone receptor interactor 11						transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)				T	PDGFRB	AML								---	---	---	---
CPSF2	53981	broad.mit.edu	37	14	92623949	92623949	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:92623949delT	uc001yah.1	+							NM_017437	NP_059133			cleavage and polyadenylation specific factor 2						histone mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	hydrolase activity|protein binding|RNA binding			ovary(2)	2		all_cancers(154;0.0766)		COAD - Colon adenocarcinoma(157;0.222)														---	---	---	---
KIAA1409	57578	broad.mit.edu	37	14	93979562	93979569	+	Intron	DEL	TTCCTTCT	-	-	rs67292676		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:93979562_93979569delTTCCTTCT	uc001ybv.1	+						KIAA1409_uc001ybs.1_Intron|KIAA1409_uc001ybu.1_Intron	NM_020818	NP_065869			hypothetical protein LOC57578							integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)														---	---	---	---
PPP4R4	57718	broad.mit.edu	37	14	94697700	94697700	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:94697700delT	uc001ycs.1	+							NM_058237	NP_478144			HEAT-like repeat-containing protein isoform 1							cytoplasm|protein serine/threonine phosphatase complex	protein binding			skin(3)|upper_aerodigestive_tract(1)	4																		---	---	---	---
SERPINA3	12	broad.mit.edu	37	14	95088657	95088657	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:95088657delT	uc001ydp.2	+						SERPINA3_uc001ydo.3_Intron|SERPINA3_uc001ydr.2_Intron|SERPINA3_uc001ydq.2_Intron|SERPINA3_uc001yds.2_Intron|SERPINA3_uc010avg.2_Intron	NM_001085	NP_001076			serpin peptidase inhibitor, clade A, member 3						acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|skin(1)	6		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)														---	---	---	---
ATG2B	55102	broad.mit.edu	37	14	96809753	96809753	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:96809753delA	uc001yfi.2	-							NM_018036	NP_060506			ATG2 autophagy related 2 homolog B											ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)														---	---	---	---
AK7	122481	broad.mit.edu	37	14	96938100	96938100	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:96938100delT	uc001yfn.2	+							NM_152327	NP_689540			adenylate kinase 7						cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			ovary(1)	1		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)														---	---	---	---
PAPOLA	10914	broad.mit.edu	37	14	97029110	97029110	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:97029110delT	uc001yfq.2	+						PAPOLA_uc001yfr.2_Intron|PAPOLA_uc010twv.1_Intron|PAPOLA_uc010avp.2_Intron	NM_032632	NP_116021			poly(A) polymerase alpha						mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|RNA binding				0		all_cancers(154;0.0555)|all_epithelial(191;0.149)|Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.213)														---	---	---	---
C14orf177	283598	broad.mit.edu	37	14	99175254	99175255	+	5'Flank	DEL	TC	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:99175254_99175255delTC	uc001yfz.1	+							NM_182560	NP_872366			hypothetical protein LOC283598												0		Melanoma(154;0.128)																---	---	---	---
CCNK	8812	broad.mit.edu	37	14	99968522	99968522	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:99968522delT	uc001ygi.3	+						CCNK_uc001ygg.3_Intron	NM_001099402	NP_001092872			cyclin K isoform 1						cell division|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein kinase binding				0		all_cancers(154;0.224)|all_epithelial(191;0.0643)|Melanoma(154;0.0866)																---	---	---	---
Unknown	0	broad.mit.edu	37	14	101377646	101377646	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:101377646delT								MIR370 (96 upstream) : SNORD113-1 (13512 downstream)																																			---	---	---	---
SNORD114-12	767590	broad.mit.edu	37	14	101434616	101434616	+	5'Flank	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:101434616delA	uc001yjc.2	+						SNORD114-13_uc001yjd.2_5'Flank	NR_003205				Homo sapiens small nucleolar RNA, C/D box 114-12 (SNORD114-12), non-coding RNA.												0																		---	---	---	---
ZNF839	55778	broad.mit.edu	37	14	102801998	102801998	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:102801998delT	uc001ylo.2	+						ZNF839_uc010awk.1_Intron|ZNF839_uc001ylp.2_Intron|ZNF839_uc001ylq.1_Intron|ZNF839_uc001ylr.2_Intron|ZNF839_uc001yls.2_Intron|ZNF839_uc001ylt.2_5'UTR	NM_018335	NP_060805			zinc finger protein 839							intracellular	zinc ion binding			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	14	103031011	103031011	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:103031011delT								ANKRD9 (54883 upstream) : RCOR1 (28222 downstream)																																			---	---	---	---
PPP1R13B	23368	broad.mit.edu	37	14	104271908	104271908	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:104271908delA	uc001yof.1	-						PPP1R13B_uc001yog.1_Intron	NM_015316	NP_056131			apoptosis-stimulating protein of p53, 1						apoptosis|induction of apoptosis|negative regulation of cell cycle	cytoplasm|nucleus|plasma membrane	protein binding			ovary(1)	1		all_cancers(154;0.173)|all_epithelial(191;0.131)|Melanoma(154;0.155)																---	---	---	---
KIF26A	26153	broad.mit.edu	37	14	104633326	104633326	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:104633326delC	uc001yos.3	+	5	1054	c.1054delC	c.(1054-1056)CCCfs	p.P352fs		NM_015656	NP_056471	Q9ULI4	KI26A_HUMAN	kinesin family member 26A	352					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			pancreas(1)	1		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)														---	---	---	---
MTA1	9112	broad.mit.edu	37	14	105930432	105930432	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:105930432delG	uc001yqx.2	+	13	1327	c.1140delG	c.(1138-1140)ACGfs	p.T380fs	MTA1_uc001yqy.2_RNA|MTA1_uc001yrb.2_Frame_Shift_Del_p.T141fs	NM_004689	NP_004680	Q13330	MTA1_HUMAN	metastasis associated protein	380					signal transduction	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(154;0.0293)|all_epithelial(191;0.128)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00897)|Epithelial(46;0.026)	Epithelial(152;0.19)														---	---	---	---
Unknown	0	broad.mit.edu	37	14	105978038	105978041	+	IGR	DEL	ACAC	-	-	rs67448562		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:105978038_105978041delACAC								C14orf80 (12454 upstream) : TMEM121 (14912 downstream)																																			---	---	---	---
ADAM6	8755	broad.mit.edu	37	14	106016171	106016172	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:106016171_106016172delTT	uc010tyt.1	-											Parts of antibodies, mostly variable regions.												0																		---	---	---	---
ADAM6	8755	broad.mit.edu	37	14	106877447	106877448	+	Intron	INS	-	TGATCT	TGATCT	rs144817208	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:106877447_106877448insTGATCT	uc010tyt.1	-						uc010tyu.1_In_Frame_Ins_p.168_169insRS					Parts of antibodies, mostly variable regions.												0																		---	---	---	---
Unknown	0	broad.mit.edu	37	15	20104041	20104041	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:20104041delT								None (None upstream) : GOLGA6L6 (633053 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	15	20710570	20710570	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:20710570delA	uc001ytg.2	-						uc010tyx.1_Intron|uc001yth.3_Intron					RecName: Full=Putative HERC2-like protein 3;																														---	---	---	---
TUBGCP5	114791	broad.mit.edu	37	15	22841913	22841913	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:22841913delA	uc001yur.3	+						TUBGCP5_uc001yuq.2_Intron	NM_052903	NP_443135			tubulin, gamma complex associated protein 5						G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			skin(1)	1		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)														---	---	---	---
CYFIP1	23191	broad.mit.edu	37	15	22939037	22939037	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:22939037delT	uc001yus.2	+						CYFIP1_uc001yut.2_Intron|CYFIP1_uc010aya.1_Intron	NM_014608	NP_055423			cytoplasmic FMR1 interacting protein 1 isoform						axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			ovary(4)|pancreas(3)|liver(1)|skin(1)	9		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)														---	---	---	---
CYFIP1	23191	broad.mit.edu	37	15	23003106	23003106	+	3'UTR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:23003106delT	uc001yus.2	+	31					CYFIP1_uc001yut.2_3'UTR|CYFIP1_uc001yuu.2_3'UTR|CYFIP1_uc001yuv.2_3'UTR	NM_014608	NP_055423			cytoplasmic FMR1 interacting protein 1 isoform						axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			ovary(4)|pancreas(3)|liver(1)|skin(1)	9		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)														---	---	---	---
HERC2P2	400322	broad.mit.edu	37	15	23299147	23299149	+	Intron	DEL	AAA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:23299147_23299149delAAA	uc001yvq.2	-						HERC2P2_uc001yvo.3_Intron|HERC2P2_uc001yvp.3_Intron					Homo sapiens mRNA for KIAA0393 protein, partial cds.												0																		---	---	---	---
Unknown	0	broad.mit.edu	37	15	23680401	23680401	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:23680401delT								GOLGA8E (231978 upstream) : MKRN3 (130053 downstream)																																			---	---	---	---
SNRPN	6638	broad.mit.edu	37	15	25222784	25222784	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:25222784delA	uc001ywp.1	+						SNRPN_uc001ywq.1_Intron|SNRPN_uc001ywr.1_Intron|SNRPN_uc001yws.1_Intron|SNRPN_uc001ywt.1_Intron|SNRPN_uc001ywv.1_Intron|SNRPN_uc001yww.1_Intron|SNRPN_uc001ywx.1_Intron|SNRPN_uc001ywz.1_Intron|PAR-SN_uc001yxa.1_Intron|SNRPN_uc001ywy.1_Intron	NM_022807	NP_073718			small nuclear ribonucleoprotein polypeptide N						RNA splicing	small nuclear ribonucleoprotein complex|spliceosomal complex	identical protein binding|RNA binding			ovary(1)	1		all_cancers(20;9.33e-22)|Breast(32;0.000625)		all cancers(64;3.38e-08)|Epithelial(43;3.45e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000207)|GBM - Glioblastoma multiforme(186;0.125)										Prader-Willi_syndrome				---	---	---	---
IPW	3653	broad.mit.edu	37	15	25417773	25417773	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:25417773delC	uc001yyp.1	+						IPW_uc010aym.1_Intron|SNORD115-2_uc001yyr.1_5'Flank|uc001yys.1_5'Flank|SNORD115-3_uc001yyt.1_5'Flank					Homo sapiens clone kid12 SNURF-SNRPN mRNA, downstream untranslated exons, alternatively spliced.												0																		---	---	---	---
Unknown	0	broad.mit.edu	37	15	25420057	25420057	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:25420057delG	uc001yys.1	+						SNORD115-3_uc001yyt.1_5'Flank|SNORD115-4_uc001yyu.1_5'Flank					Homo sapiens clone Rt-5 SNURF-SNRPN mRNA, downstream untranslated exons, alternatively spliced.																														---	---	---	---
UBE3A	7337	broad.mit.edu	37	15	25650459	25650459	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:25650459delA	uc001zaq.2	-						UBE3A_uc001zar.2_Intron|UBE3A_uc001zas.2_Intron|UBE3A_uc001zat.2_Intron	NM_000462	NP_000453			ubiquitin protein ligase E3A isoform 2						brain development|interspecies interaction between organisms|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			upper_aerodigestive_tract(1)|ovary(1)|breast(1)	3		all_cancers(20;3.47e-21)|Breast(32;0.00123)		all cancers(64;2.78e-08)|Epithelial(43;8.85e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0155)|Lung(196;0.0616)														---	---	---	---
HERC2	8924	broad.mit.edu	37	15	28388214	28388214	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:28388214delA	uc001zbj.2	-							NM_004667	NP_004658			hect domain and RLD 2						DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)														---	---	---	---
HERC2	8924	broad.mit.edu	37	15	28473276	28473277	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:28473276_28473277delAA	uc001zbj.2	-							NM_004667	NP_004658			hect domain and RLD 2						DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)														---	---	---	---
HERC2	8924	broad.mit.edu	37	15	28525215	28525215	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:28525215delT	uc001zbj.2	-	5	647	c.541delA	c.(541-543)AGTfs	p.S181fs	HERC2_uc001zbl.1_5'UTR	NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	181					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)														---	---	---	---
Unknown	0	broad.mit.edu	37	15	28913367	28913367	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:28913367delT	uc010azc.2	+						uc010uao.1_Intron					Homo sapiens I.M.A.G.E. clone 321824, mRNA sequence.																														---	---	---	---
TJP1	7082	broad.mit.edu	37	15	30020390	30020391	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:30020390_30020391delTT	uc001zcr.2	-						TJP1_uc010azl.2_Intron|TJP1_uc001zcq.2_Intron|TJP1_uc001zcs.2_Intron	NM_003257	NP_003248			tight junction protein 1 isoform a						cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)														---	---	---	---
TRPM1	4308	broad.mit.edu	37	15	31293996	31293997	+	3'UTR	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:31293996_31293997delAA	uc001zfm.2	-	27					TRPM1_uc010azy.2_3'UTR|TRPM1_uc001zfl.2_RNA	NM_002420	NP_002411			transient receptor potential cation channel,						cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)														---	---	---	---
TRPM1	4308	broad.mit.edu	37	15	31359898	31359898	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:31359898delT	uc001zfm.2	-						TRPM1_uc010azy.2_Intron|TRPM1_uc001zfl.2_Intron|uc010ubm.1_5'Flank|MIR211_hsa-mir-211|MI0000287_5'Flank|uc010ubn.1_5'Flank	NM_002420	NP_002411			transient receptor potential cation channel,						cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)														---	---	---	---
RYR3	6263	broad.mit.edu	37	15	33873557	33873557	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:33873557delA	uc001zhi.2	+						RYR3_uc010bar.2_Intron	NM_001036	NP_001027			ryanodine receptor 3						cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)														---	---	---	---
AQR	9716	broad.mit.edu	37	15	35178962	35178962	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:35178962delA	uc001ziv.2	-							NM_014691	NP_055506			aquarius							catalytic step 2 spliceosome	RNA binding			large_intestine(1)	1		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)														---	---	---	---
AQR	9716	broad.mit.edu	37	15	35210693	35210693	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:35210693delT	uc001ziv.2	-							NM_014691	NP_055506			aquarius							catalytic step 2 spliceosome	RNA binding			large_intestine(1)	1		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)														---	---	---	---
ATPBD4	89978	broad.mit.edu	37	15	35834516	35834517	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:35834516_35834517insT	uc001zja.2	-						ATPBD4_uc001ziz.2_Intron|ATPBD4_uc001zjb.2_Intron	NM_080650	NP_542381			ATP binding domain 4 isoform 1												0		all_epithelial(112;2.11e-09)|Lung NSC(122;2.38e-08)|all_lung(180;3.65e-07)		all cancers(64;9.9e-19)|GBM - Glioblastoma multiforme(113;2.01e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)														---	---	---	---
C15orf41	84529	broad.mit.edu	37	15	36983573	36983574	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:36983573_36983574delTT	uc001zje.3	+						C15orf41_uc001zjd.2_Intron|C15orf41_uc010bbb.1_Intron|C15orf41_uc001zjf.2_Intron|C15orf41_uc010uci.1_Intron	NM_001130010	NP_001123482			hypothetical protein LOC84529 isoform 1								protein binding			pancreas(1)	1		all_epithelial(112;3.06e-10)|Lung NSC(122;6.48e-08)|all_lung(180;8.31e-07)|Melanoma(134;0.222)		all cancers(64;1.76e-19)|GBM - Glioblastoma multiforme(113;5.03e-07)|BRCA - Breast invasive adenocarcinoma(123;0.11)														---	---	---	---
TMCO5A	145942	broad.mit.edu	37	15	38234246	38234246	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:38234246delG	uc001zjw.2	+						TMCO5A_uc001zjv.1_Intron|TMCO5A_uc010bbc.1_Intron	NM_152453	NP_689666			transmembrane and coiled-coil domains 5A							integral to membrane				central_nervous_system(1)	1																		---	---	---	---
THBS1	7057	broad.mit.edu	37	15	39882846	39882846	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:39882846delT	uc001zkh.2	+						THBS1_uc010bbi.2_Intron	NM_003246	NP_003237			thrombospondin 1 precursor						activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			ovary(3)|central_nervous_system(3)	6		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)													---	---	---	---
EIF2AK4	440275	broad.mit.edu	37	15	40300128	40300128	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:40300128delT	uc001zkm.1	+						EIF2AK4_uc010bbj.1_Intron|EIF2AK4_uc001zkn.1_Intron|EIF2AK4_uc001zko.1_Intron|EIF2AK4_uc010bbk.1_Intron	NM_001013703	NP_001013725			eukaryotic translation initiation factor 2 alpha						translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			lung(2)|stomach(1)|skin(1)	4		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)														---	---	---	---
EIF2AK4	440275	broad.mit.edu	37	15	40314943	40314943	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:40314943delT	uc001zkm.1	+						EIF2AK4_uc010bbj.1_Intron|EIF2AK4_uc001zkn.1_Intron|EIF2AK4_uc001zko.1_Intron|EIF2AK4_uc010bbk.1_Intron	NM_001013703	NP_001013725			eukaryotic translation initiation factor 2 alpha						translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			lung(2)|stomach(1)|skin(1)	4		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)														---	---	---	---
BUB1B	701	broad.mit.edu	37	15	40494488	40494488	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:40494488delA	uc001zkx.3	+						BUB1B_uc010ucl.1_Intron	NM_001211	NP_001202			budding uninhibited by benzimidazoles 1 beta						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|kidney(1)	4		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)				Mis|N|F|S			rhabdomyosarcoma			Mosaic_Variegated_Aneuploidy_Syndrome				---	---	---	---
PLCB2	5330	broad.mit.edu	37	15	40583165	40583165	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:40583165delG	uc001zld.2	-						PLCB2_uc001zlc.2_Intron|PLCB2_uc010bbo.2_Intron|PLCB2_uc010ucm.1_Intron	NM_004573	NP_004564			phospholipase C, beta 2						activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(3)|breast(3)|kidney(1)|pancreas(1)	8		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)														---	---	---	---
EXD1	161829	broad.mit.edu	37	15	41483956	41483956	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:41483956delA	uc001znk.2	-						EXD1_uc001znj.2_5'Flank|EXD1_uc010ucv.1_Intron	NM_152596	NP_689809			exonuclease 3'-5' domain containing 1						nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			ovary(1)	1																		---	---	---	---
RTF1	23168	broad.mit.edu	37	15	41749724	41749724	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:41749724delA	uc001zny.2	+							NM_015138	NP_055953			Paf1/RNA polymerase II complex component						histone modification|regulation of transcription, DNA-dependent|transcription initiation, DNA-dependent	nucleoplasm	protein binding|single-stranded DNA binding			ovary(2)	2		all_cancers(109;1.79e-19)|all_epithelial(112;8.18e-17)|Lung NSC(122;3.16e-11)|all_lung(180;8.14e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;1.15e-16)|GBM - Glioblastoma multiforme(113;1.81e-06)|BRCA - Breast invasive adenocarcinoma(123;0.119)														---	---	---	---
SPTBN5	51332	broad.mit.edu	37	15	42146849	42146849	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:42146849delA	uc001zos.2	-							NM_016642	NP_057726			spectrin, beta, non-erythrocytic 5						actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)														---	---	---	---
TMEM87A	25963	broad.mit.edu	37	15	42536228	42536228	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:42536228delA	uc010udd.1	-						TMEM87A_uc001zpf.3_Intron|TMEM87A_uc010bcu.1_Intron	NM_015497	NP_056312			transmembrane protein 87A isoform 1							integral to membrane				ovary(1)	1		all_cancers(109;4.28e-16)|all_epithelial(112;1.04e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;1.03e-06)														---	---	---	---
UBR1	197131	broad.mit.edu	37	15	43360383	43360388	+	Intron	DEL	TTTTTT	-	-	rs35199000		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:43360383_43360388delTTTTTT	uc001zqq.2	-						UBR1_uc010udk.1_Intron	NM_174916	NP_777576			ubiquitin protein ligase E3 component n-recognin						cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			lung(1)	1		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)														---	---	---	---
CATSPER2	117155	broad.mit.edu	37	15	43927354	43927354	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:43927354delT	uc001zsh.2	-						STRC_uc010udz.1_5'Flank|CATSPER2_uc010bdm.2_Intron|CATSPER2_uc001zsi.2_Intron|CATSPER2_uc001zsj.2_Intron	NM_172095	NP_742093			sperm-associated cation channel 2 isoform 2						cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|protein binding|voltage-gated ion channel activity			ovary(1)	1		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)												OREG0003957	type=REGULATORY REGION|Gene=AK093318|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	---	---	---	---
FRMD5	84978	broad.mit.edu	37	15	44211597	44211598	+	Intron	INS	-	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:44211597_44211598insC	uc001ztl.2	-						FRMD5_uc001ztk.1_Intron|FRMD5_uc001ztm.2_Intron|FRMD5_uc001ztn.2_Intron	NM_032892	NP_116281			FERM domain containing 5 isoform 2							cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			ovary(1)	1		all_cancers(109;2.29e-15)|all_epithelial(112;9.98e-13)|Lung NSC(122;4.89e-08)|all_lung(180;5.08e-07)|Melanoma(134;0.0275)		all cancers(107;8.63e-20)|GBM - Glioblastoma multiforme(94;3.63e-06)														---	---	---	---
SPG11	80208	broad.mit.edu	37	15	44887360	44887360	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:44887360delA	uc001ztx.2	-						SPG11_uc010ueh.1_Intron|SPG11_uc010uei.1_Intron|SPG11_uc001zty.1_Intron	NM_025137	NP_079413			spatacsin isoform 1						cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)														---	---	---	---
B2M	567	broad.mit.edu	37	15	45008499	45008499	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:45008499delT	uc001zuc.2	+						B2M_uc010uek.1_3'UTR|B2M_uc010bdx.1_Intron	NM_004048	NP_004039			beta-2-microglobulin precursor						antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of defense response to virus by virus|viral reproduction	early endosome membrane|Golgi membrane|MHC class I protein complex	protein binding			ovary(2)|skin(1)	3		all_cancers(109;1.88e-13)|all_epithelial(112;2.13e-11)|Lung NSC(122;2.22e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;4.16e-21)|GBM - Glioblastoma multiforme(94;8.97e-07)|COAD - Colon adenocarcinoma(120;0.0357)|Colorectal(105;0.0377)|Lung(196;0.0903)|LUSC - Lung squamous cell carcinoma(244;0.192)														---	---	---	---
SLC28A2	9153	broad.mit.edu	37	15	45561372	45561372	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:45561372delA	uc001zva.2	+							NM_004212	NP_004203			solute carrier family 28 (sodium-coupled						nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding|nucleoside:sodium symporter activity|purine nucleoside transmembrane transporter activity			ovary(4)	4		all_cancers(109;8.53e-07)|all_epithelial(112;1.39e-05)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.77e-16)|GBM - Glioblastoma multiforme(94;2.71e-06)														---	---	---	---
SQRDL	58472	broad.mit.edu	37	15	45980714	45980715	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:45980714_45980715delTT	uc001zvt.2	+						SQRDL_uc001zvu.2_Intron|SQRDL_uc001zvv.2_Intron	NM_021199	NP_067022			sulfide dehydrogenase like precursor								oxidoreductase activity			ovary(1)	1		Lung NSC(122;0.000117)|all_lung(180;0.000737)|Melanoma(134;0.0417)		all cancers(107;5.89e-18)|GBM - Glioblastoma multiforme(94;1.21e-06)|COAD - Colon adenocarcinoma(120;0.17)|Colorectal(133;0.188)														---	---	---	---
MYEF2	50804	broad.mit.edu	37	15	48433478	48433478	+	3'UTR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:48433478delA	uc001zwi.3	-	17					SLC24A5_uc001zwe.2_Intron|SLC24A5_uc010bel.2_Intron|MYEF2_uc001zwg.3_3'UTR|MYEF2_uc001zwh.3_3'UTR|MYEF2_uc001zwj.3_3'UTR|SLC24A5_uc001zwk.2_Intron	NM_016132	NP_057216			myelin expression factor 2						transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding|nucleotide binding|RNA binding			lung(2)|ovary(1)	3		all_lung(180;0.00217)		all cancers(107;3.73e-10)|GBM - Glioblastoma multiforme(94;7.81e-07)														---	---	---	---
DUT	1854	broad.mit.edu	37	15	48626883	48626883	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:48626883delT	uc001zws.2	+						DUT_uc001zwt.2_Intron|DUT_uc001zwu.2_Intron|DUT_uc001zwv.2_Intron|DUT_uc001zww.2_Intron|uc010ben.1_5'Flank	NM_001025248	NP_001020419			deoxyuridine triphosphatase isoform 1 precursor						DNA replication|dUTP metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside biosynthetic process	mitochondrion|nucleoplasm	dUTP diphosphatase activity|protein binding				0		all_lung(180;0.00265)		all cancers(107;2.66e-09)|GBM - Glioblastoma multiforme(94;6.76e-07)									Modulation_of_nucleotide_pools					---	---	---	---
SECISBP2L	9728	broad.mit.edu	37	15	49293299	49293299	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:49293299delA	uc001zxe.1	-						SECISBP2L_uc001zxd.1_Intron|SECISBP2L_uc010bep.1_Intron	NM_014701	NP_055516			SECIS binding protein 2-like											breast(1)|skin(1)	2																		---	---	---	---
COPS2	9318	broad.mit.edu	37	15	49429779	49429779	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:49429779delA	uc001zxf.2	-						COPS2_uc001zxh.2_Intron|COPS2_uc010ufa.1_Intron	NM_004236	NP_004227			COP9 constitutive photomorphogenic homolog						cullin deneddylation|transcription from RNA polymerase II promoter	cytoplasm|signalosome	protein binding|signal transducer activity			lung(1)	1		all_lung(180;0.0428)		all cancers(107;1.34e-07)|GBM - Glioblastoma multiforme(94;3.02e-05)														---	---	---	---
HDC	3067	broad.mit.edu	37	15	50555231	50555231	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:50555231delA	uc001zxz.2	-						HDC_uc010uff.1_Intron|HDC_uc010bet.1_Intron|HDC_uc010beu.1_Intron	NM_002112	NP_002103			histidine decarboxylase						catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)													---	---	---	---
GABPB1	2553	broad.mit.edu	37	15	50571062	50571062	+	Intron	DEL	A	-	-	rs71993721		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:50571062delA	uc001zyb.2	-						GABPB1_uc001zya.2_Intron|GABPB1_uc010ufg.1_Intron	NM_005254	NP_005245			GA binding protein transcription factor, beta						positive regulation of transcription from RNA polymerase II promoter	nucleus	protein binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)	1																		---	---	---	---
TRPM7	54822	broad.mit.edu	37	15	50862369	50862369	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:50862369delA	uc001zyt.3	-						TRPM7_uc001zyr.2_Intron	NM_017672	NP_060142			transient receptor potential cation channel,						cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			ovary(4)|stomach(3)|breast(1)|central_nervous_system(1)|skin(1)	10				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)														---	---	---	---
AP4E1	23431	broad.mit.edu	37	15	51221550	51221550	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:51221550delT	uc001zyx.1	+						AP4E1_uc010ufi.1_Intron|AP4E1_uc010ufj.1_Intron|AP4E1_uc010ufk.1_Intron	NM_007347	NP_031373			adaptor-related protein complex 4, epsilon 1						intracellular protein transport|vesicle-mediated transport	COPI vesicle coat	binding|structural molecule activity				0				all cancers(107;0.000893)|GBM - Glioblastoma multiforme(94;0.00364)														---	---	---	---
CYP19A1	1588	broad.mit.edu	37	15	51510860	51510860	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:51510860delA	uc001zyz.3	-						CYP19A1_uc001zza.3_Intron|CYP19A1_uc001zzb.2_Intron|CYP19A1_uc001zzc.1_5'Flank	NM_031226	NP_112503			cytochrome P450, family 19						estrogen biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|membrane fraction	aromatase activity|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(3)	3				all cancers(107;0.000372)|GBM - Glioblastoma multiforme(94;0.0128)	Aminoglutethimide(DB00357)|Anastrozole(DB01217)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Diethylstilbestrol(DB00255)|Exemestane(DB00990)|Letrozole(DB01006)|Testolactone(DB00894)|Testosterone(DB00624)													---	---	---	---
GLDN	342035	broad.mit.edu	37	15	51643233	51643233	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:51643233delT	uc002aba.2	+						GLDN_uc010bez.1_Intron	NM_181789	NP_861454			gliomedin						cell differentiation|nervous system development	collagen|integral to membrane|plasma membrane				ovary(2)	2				all cancers(107;0.00194)|GBM - Glioblastoma multiforme(94;0.00942)														---	---	---	---
DMXL2	23312	broad.mit.edu	37	15	51834793	51834793	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:51834793delT	uc002abf.2	-						DMXL2_uc010ufy.1_Intron|DMXL2_uc010bfa.2_Intron	NM_015263	NP_056078			Dmx-like 2							cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)														---	---	---	---
WDR72	256764	broad.mit.edu	37	15	53908566	53908566	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:53908566delT	uc002acj.2	-						WDR72_uc010bfi.1_Intron	NM_182758	NP_877435			WD repeat domain 72											lung(1)|skin(1)	2				all cancers(107;0.0511)														---	---	---	---
WDR72	256764	broad.mit.edu	37	15	54003203	54003203	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:54003203delT	uc002acj.2	-						WDR72_uc010bfi.1_Intron	NM_182758	NP_877435			WD repeat domain 72											lung(1)|skin(1)	2				all cancers(107;0.0511)														---	---	---	---
PIGB	9488	broad.mit.edu	37	15	55611484	55611484	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:55611484delG	uc002act.2	+	1	352	c.36delG	c.(34-36)CCGfs	p.P12fs	uc002acs.2_5'Flank|PIGB_uc010ugg.1_5'UTR	NM_004855	NP_004846	Q92521	PIGB_HUMAN	phosphatidylinositol glycan, class B	12					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	integral to membrane|intrinsic to endoplasmic reticulum membrane	glycolipid mannosyltransferase activity				0				all cancers(107;0.0255)														---	---	---	---
CCPG1	9236	broad.mit.edu	37	15	55653148	55653148	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:55653148delT	uc002acv.1	-						CCPG1_uc002acy.2_Intron|CCPG1_uc002acu.1_Intron|CCPG1_uc002acw.1_Intron|CCPG1_uc002acx.2_Intron|CCPG1_uc010bfk.1_Intron|CCPG1_uc002acz.1_Intron	NM_020739	NP_065790			cell cycle progression 1 isoform 2						cell cycle	integral to membrane				ovary(1)	1				all cancers(107;0.0354)														---	---	---	---
CCPG1	9236	broad.mit.edu	37	15	55723120	55723120	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:55723120delT	uc002acy.2	-						DYX1C1_uc010ugh.1_Intron|DYX1C1_uc010ugi.1_Intron|DYX1C1_uc002adb.2_Intron|DYX1C1_uc002adc.2_Intron|DYX1C1_uc002add.2_Intron	NM_020739	NP_065790			cell cycle progression 1 isoform 2						cell cycle	integral to membrane				ovary(1)	1				all cancers(107;0.0354)														---	---	---	---
NEDD4	4734	broad.mit.edu	37	15	56144502	56144502	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:56144502delA	uc002adj.2	-						NEDD4_uc002adl.2_Intron|NEDD4_uc002adi.2_Intron|NEDD4_uc010ugj.1_Intron|NEDD4_uc010bfm.2_Intron|NEDD4_uc002adk.2_Intron	NM_198400	NP_006145			neural precursor cell expressed, developmentally						development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|RNA polymerase binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|breast(1)	4				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)														---	---	---	---
ZNF280D	54816	broad.mit.edu	37	15	57138419	57138420	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:57138419_57138420insA	uc002adw.1	-							NM_001002843	NP_001002843			suppressor of hairy wing homolog 4 isoform 2						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.0399)|GBM - Glioblastoma multiforme(80;0.0787)														---	---	---	---
FAM63B	54629	broad.mit.edu	37	15	59146925	59146926	+	3'UTR	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:59146925_59146926insT	uc002afj.2	+	9					FAM63B_uc002afi.2_3'UTR|FAM63B_uc002afk.2_RNA|FAM63B_uc002afl.2_RNA	NM_001040450	NP_001035540			hypothetical protein LOC54629 isoform a											central_nervous_system(1)	1																		---	---	---	---
SLTM	79811	broad.mit.edu	37	15	59192258	59192261	+	Intron	DEL	AAAA	-	-	rs35822874		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:59192258_59192261delAAAA	uc002afp.2	-						SLTM_uc002afo.2_Intron|SLTM_uc002afq.2_Intron|SLTM_uc010bgd.2_Intron|SLTM_uc002afr.1_Intron	NM_024755	NP_079031			modulator of estrogen induced transcription						apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)	1																		---	---	---	---
VPS13C	54832	broad.mit.edu	37	15	62147035	62147035	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:62147035delA	uc002agz.2	-						VPS13C_uc002aha.2_Intron	NM_020821	NP_065872			vacuolar protein sorting 13C protein isoform 2A						protein localization					ovary(2)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	15	62654383	62654383	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:62654383delT								C2CD4B (196901 upstream) : MGC15885 (274988 downstream)																																			---	---	---	---
TLN2	83660	broad.mit.edu	37	15	62999154	62999154	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:62999154delA	uc002alb.3	+							NM_015059	NP_055874			talin 2						cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11																		---	---	---	---
TLN2	83660	broad.mit.edu	37	15	63014438	63014438	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:63014438delT	uc002alb.3	+							NM_015059	NP_055874			talin 2						cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11																		---	---	---	---
HERC1	8925	broad.mit.edu	37	15	63964903	63964903	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:63964903delA	uc002amp.2	-							NM_003922	NP_003913			hect domain and RCC1-like domain 1						protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19																		---	---	---	---
SNX1	6642	broad.mit.edu	37	15	64419305	64419305	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:64419305delA	uc002amv.2	+						SNX1_uc010bgv.2_Intron|SNX1_uc010uio.1_Intron|SNX1_uc002amw.2_Intron|SNX1_uc002amx.2_Intron|SNX1_uc002amy.2_Intron|SNX1_uc010bgw.2_Intron	NM_003099	NP_003090			sorting nexin 1 isoform a						cell communication|early endosome to Golgi transport|endocytosis|intracellular protein transport	early endosome membrane|Golgi apparatus	phosphatidylinositol binding|protein binding|protein transporter activity				0																		---	---	---	---
PPIB	5479	broad.mit.edu	37	15	64448020	64448021	+	3'UTR	DEL	AA	-	-	rs67185132		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:64448020_64448021delAA	uc002and.2	-	5					SNX22_uc002anc.1_3'UTR	NM_000942	NP_000933			peptidylprolyl isomerase B precursor						protein folding	endoplasmic reticulum lumen|melanosome	peptide binding|peptidyl-prolyl cis-trans isomerase activity|unfolded protein binding				0					L-Proline(DB00172)													---	---	---	---
TRIP4	9325	broad.mit.edu	37	15	64717846	64717847	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:64717846_64717847delTT	uc002anm.2	+							NM_016213	NP_057297			thyroid hormone receptor interactor 4						positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	ligand-dependent nuclear receptor binding|transcription coactivator activity|zinc ion binding			ovary(1)|kidney(1)|skin(1)	3																		---	---	---	---
ZNF609	23060	broad.mit.edu	37	15	64923741	64923741	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:64923741delT	uc002ann.2	+							NM_015042	NP_055857			zinc finger protein 609							nucleus	zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3																		---	---	---	---
SPG21	51324	broad.mit.edu	37	15	65266813	65266813	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:65266813delA	uc002aod.2	-						SPG21_uc002aoe.2_Intron|SPG21_uc010bhb.2_Intron|SPG21_uc010bhc.2_Intron	NM_001127889	NP_001121361			spastic paraplegia 21 isoform a						cell death	cytosol|endosome membrane|trans-Golgi network transport vesicle	CD4 receptor binding				0																		---	---	---	---
PDCD7	10081	broad.mit.edu	37	15	65411613	65411613	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:65411613delA	uc002aol.2	-							NM_005707	NP_005698			programmed cell death 7						apoptosis|induction of apoptosis|response to glucocorticoid stimulus	U12-type spliceosomal complex					0																		---	---	---	---
DPP8	54878	broad.mit.edu	37	15	65748819	65748819	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:65748819delA	uc002aov.2	-						DPP8_uc002aow.2_Intron|DPP8_uc010uiv.1_Intron|DPP8_uc002aox.2_Intron|DPP8_uc002aoy.2_Intron|DPP8_uc002aoz.2_Intron|DPP8_uc010bhj.2_Intron|DPP8_uc002apa.2_Intron|DPP8_uc010bhi.2_Intron|DPP8_uc010bhk.1_Intron	NM_130434	NP_569118			dipeptidyl peptidase 8 isoform 1						immune response|proteolysis	cytoplasm|membrane|nucleus	aminopeptidase activity|dipeptidyl-peptidase activity|serine-type peptidase activity			ovary(1)	1																		---	---	---	---
DENND4A	10260	broad.mit.edu	37	15	65989151	65989152	+	Intron	DEL	TT	-	-	rs72741230	byFrequency;by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:65989151_65989152delTT	uc002aph.2	-						DENND4A_uc002api.2_Intron|DENND4A_uc002apj.3_Intron	NM_005848	NP_005839			DENN/MADD domain containing 4A isoform 2						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4																		---	---	---	---
TIPIN	54962	broad.mit.edu	37	15	66629667	66629670	+	Intron	DEL	TTTT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:66629667_66629670delTTTT	uc002apr.2	-						TIPIN_uc010ujn.1_Intron|TIPIN_uc010ujo.1_Intron	NM_017858	NP_060328			TIMELESS interacting protein						cell division|DNA replication checkpoint|intra-S DNA damage checkpoint|mitosis|positive regulation of cell proliferation|regulation of DNA replication involved in S phase|replication fork protection	cytoplasm|nuclear chromatin	protein binding			ovary(1)	1																		---	---	---	---
AAGAB	79719	broad.mit.edu	37	15	67528577	67528577	+	Intron	DEL	A	-	-	rs35008448		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:67528577delA	uc002aqk.3	-						AAGAB_uc002aql.2_Intron|AAGAB_uc010uju.1_Intron	NM_024666	NP_078942			alpha- and gamma-adaptin-binding protein p34						protein transport	cytoplasm					0																		---	---	---	---
CALML4	91860	broad.mit.edu	37	15	68491623	68491624	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:68491623_68491624insT	uc002arb.2	-						CALML4_uc002arc.2_Intron|CALML4_uc002ard.2_Intron|CALML4_uc002are.2_Intron|CALML4_uc010bhz.2_Intron	NM_033429	NP_219501			calmodulin-like 4 isoform 1								calcium ion binding				0																		---	---	---	---
PAQR5	54852	broad.mit.edu	37	15	69692557	69692558	+	Intron	DEL	AG	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:69692557_69692558delAG	uc002arz.2	+						PAQR5_uc002asa.2_Intron	NM_017705	NP_060175			progestin and adipoQ receptor family member V						cell differentiation|multicellular organismal development|oogenesis	integral to membrane	receptor activity|steroid binding			ovary(2)	2																		---	---	---	---
KIF23	9493	broad.mit.edu	37	15	69715487	69715488	+	Intron	DEL	TC	-	-	rs7180624	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:69715487_69715488delTC	uc002asb.2	+						KIF23_uc002asc.2_Intron|KIF23_uc010bii.2_Intron|KIF23_uc010ukc.1_Intron|KIF23_uc010bih.1_Intron	NM_138555	NP_612565			kinesin family member 23 isoform 1						blood coagulation|cytokinesis|microtubule-based movement|mitosis|mitotic spindle elongation	cytosol|kinesin complex|microtubule|midbody|nucleoplasm|spindle	ATP binding|microtubule motor activity|protein binding				0																		---	---	---	---
KIF23	9493	broad.mit.edu	37	15	69728443	69728443	+	Intron	DEL	T	-	-	rs28533847		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:69728443delT	uc002asb.2	+						KIF23_uc002asc.2_Intron|KIF23_uc010bii.2_Intron|KIF23_uc010ukc.1_Intron|KIF23_uc010bih.1_Intron	NM_138555	NP_612565			kinesin family member 23 isoform 1						blood coagulation|cytokinesis|microtubule-based movement|mitosis|mitotic spindle elongation	cytosol|kinesin complex|microtubule|midbody|nucleoplasm|spindle	ATP binding|microtubule motor activity|protein binding				0																		---	---	---	---
LRRC49	54839	broad.mit.edu	37	15	71203971	71203972	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:71203971_71203972insA	uc002asw.2	+						LRRC49_uc002asu.2_Intron|LRRC49_uc002asx.2_Intron|LRRC49_uc010ukf.1_Intron|LRRC49_uc002asy.2_Intron|LRRC49_uc002asz.2_Intron	NM_017691	NP_060161			leucine rich repeat containing 49							cytoplasm|microtubule				ovary(1)	1																		---	---	---	---
THSD4	79875	broad.mit.edu	37	15	72041049	72041049	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:72041049delA	uc002atb.1	+						THSD4_uc002ate.2_Intron	NM_024817	NP_079093			thrombospondin, type I, domain containing 4							proteinaceous extracellular matrix	metalloendopeptidase activity			ovary(2)	2																		---	---	---	---
GRAMD2	196996	broad.mit.edu	37	15	72462287	72462287	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:72462287delA	uc002atq.2	-						GRAMD2_uc010bis.2_Intron	NM_001012642	NP_001012660			GRAM domain containing 2							integral to membrane					0																		---	---	---	---
NPTN	27020	broad.mit.edu	37	15	73854451	73854451	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:73854451delA	uc002avs.2	-						NPTN_uc010bjc.2_Intron|NPTN_uc002avt.2_Intron|NPTN_uc002avr.2_Intron|NPTN_uc010ula.1_Intron	NM_012428	NP_036560			neuroplastin isoform b precursor						elevation of cytosolic calcium ion concentration|homophilic cell adhesion|long-term synaptic potentiation|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of long-term neuronal synaptic plasticity|positive regulation of neuron projection development|positive regulation of protein phosphorylation	integral to membrane|plasma membrane|presynaptic membrane	cell adhesion molecule binding|type 1 fibroblast growth factor receptor binding				0																		---	---	---	---
LOXL1	4016	broad.mit.edu	37	15	74235283	74235285	+	In_Frame_Del	DEL	GGA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:74235283_74235285delGGA	uc002awc.1	+	2	1527_1529	c.1191_1193delGGA	c.(1189-1194)GCGGAG>GCG	p.E399del		NM_005576	NP_005567	Q08397	LOXL1_HUMAN	lysyl oxidase-like 1 preproprotein	399	Lysyl-oxidase like.				protein deamination	extracellular space	copper ion binding				0																		---	---	---	---
SIN3A	25942	broad.mit.edu	37	15	75722399	75722399	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:75722399delT	uc002bai.2	-						SIN3A_uc002baj.2_Intron|SIN3A_uc010uml.1_Intron|SIN3A_uc002bak.3_Intron	NM_015477	NP_056292			transcriptional co-repressor Sin3A						blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			skin(3)|ovary(1)|lung(1)	5																		---	---	---	---
UBE2Q2	92912	broad.mit.edu	37	15	76161275	76161278	+	Intron	DEL	TTCT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:76161275_76161278delTTCT	uc002bbg.2	+						UBE2Q2_uc002bbh.2_Intron|UBE2Q2_uc010umn.1_Intron|UBE2Q2_uc002bbi.2_Intron	NM_173469	NP_775740			ubiquitin-conjugating enzyme E2Q 2 isoform 1						protein K48-linked ubiquitination	cytoplasm	ATP binding|ubiquitin-protein ligase activity			ovary(2)	2																		---	---	---	---
ISL2	64843	broad.mit.edu	37	15	76633897	76633897	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:76633897delC	uc002bbw.1	+							NM_145805	NP_665804			ISL LIM homeobox 2							nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0																		---	---	---	---
TBC1D2B	23102	broad.mit.edu	37	15	78316386	78316386	+	Intron	DEL	T	-	-	rs1992470	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:78316386delT	uc002bcy.3	-						TBC1D2B_uc010bla.2_Intron	NM_144572	NP_653173			TBC1 domain family, member 2B isoform a							intracellular	protein binding|Rab GTPase activator activity			ovary(1)|large_intestine(1)|breast(1)	3																		---	---	---	---
CIB2	10518	broad.mit.edu	37	15	78397504	78397504	+	3'UTR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:78397504delT	uc002bdb.1	-	6					CIB2_uc002bdc.1_3'UTR	NM_006383	NP_006374			DNA-dependent protein kinase catalytic								calcium ion binding				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	15	79156196	79156196	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:79156196delA								ADAMTS7 (52423 upstream) : MORF4L1 (8976 downstream)																																			---	---	---	---
ST20	400410	broad.mit.edu	37	15	80215063	80215063	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:80215063delC	uc002bfa.3	-						C15orf37_uc002bfb.2_5'Flank	NM_001100880	NP_001094350			cervical cancer suppressor-1												0																		---	---	---	---
GOLGA6L10	647042	broad.mit.edu	37	15	83003607	83003608	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:83003607_83003608delTT	uc010unt.1	-						uc002bhl.2_Intron|uc002bhm.2_Intron|GOLGA6L10_uc010uny.1_Intron|uc002bhz.2_5'Flank					Homo sapiens cDNA FLJ40113 fis, clone TESTI2008621.												0																		---	---	---	---
C15orf40	123207	broad.mit.edu	37	15	83657726	83657727	+	3'UTR	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:83657726_83657727insT	uc010uon.1	-	4					FAM103A1_uc002bjl.1_Intron	NM_001160116	NP_001153588			hypothetical protein LOC123207 isoform e											skin(1)	1																		---	---	---	---
ADAMTSL3	57188	broad.mit.edu	37	15	84560208	84560208	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:84560208delA	uc002bjz.3	+						ADAMTSL3_uc010bmt.1_Intron|ADAMTSL3_uc010bmu.1_Intron	NM_207517	NP_997400			ADAMTS-like 3 precursor							proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)															---	---	---	---
AGBL1	123624	broad.mit.edu	37	15	86923509	86923510	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:86923509_86923510delTT	uc002blz.1	+							NM_152336	NP_689549			ATP/GTP binding protein-like 1						C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	15	87757788	87757789	+	IGR	INS	-	GGAA	GGAA	rs57002659		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:87757788_87757789insGGAA								AGBL1 (185505 upstream) : NCRNA00052 (362371 downstream)																																			---	---	---	---
NTRK3	4916	broad.mit.edu	37	15	88670279	88670279	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:88670279delT	uc002bme.1	-						NTRK3_uc002bmh.2_Intron|NTRK3_uc002bmf.1_Intron|NTRK3_uc010upl.1_Intron|NTRK3_uc010bnh.1_Intron|NTRK3_uc002bmg.2_Intron	NM_001012338	NP_001012338			neurotrophic tyrosine kinase, receptor, type 3						transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)					T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			---	---	---	---
WDR93	56964	broad.mit.edu	37	15	90265496	90265496	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:90265496delA	uc002boj.2	+						WDR93_uc010bnr.2_Intron|WDR93_uc010upz.1_Intron	NM_020212	NP_064597			WD repeat domain 93						electron transport chain	mitochondrial inner membrane	oxidoreductase activity, acting on NADH or NADPH			ovary(2)	2	Lung NSC(78;0.0237)|all_lung(78;0.0478)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|BRCA - Breast invasive adenocarcinoma(143;0.128)															---	---	---	---
BLM	641	broad.mit.edu	37	15	91308328	91308328	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:91308328delT	uc002bpr.2	+						BLM_uc010uqh.1_Intron|BLM_uc010uqi.1_Intron|BLM_uc010bnx.2_Intron|BLM_uc002bps.1_Intron	NM_000057	NP_000048			Bloom syndrome protein						double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			ovary(3)|skin(2)|breast(1)	6	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)					Mis|N|F			leukemia|lymphoma|skin squamous cell |other cancers		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Bloom_syndrome				---	---	---	---
CHD2	1106	broad.mit.edu	37	15	93444561	93444561	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:93444561delT	uc002bsp.2	+						CHD2_uc002bsm.1_Intron|CHD2_uc002bsn.2_Intron|CHD2_uc002bso.1_Intron	NM_001271	NP_001262			chromodomain helicase DNA binding protein 2						regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)															---	---	---	---
MCTP2	55784	broad.mit.edu	37	15	94884266	94884266	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:94884266delG	uc002btj.2	+						MCTP2_uc010urg.1_Intron|MCTP2_uc002bti.2_Intron|MCTP2_uc010boj.2_Intron|MCTP2_uc010bok.2_Intron|MCTP2_uc002btg.3_3'UTR|MCTP2_uc002bth.3_3'UTR	NM_018349	NP_060819			multiple C2 domains, transmembrane 2 isoform 1						calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)															---	---	---	---
MCTP2	55784	broad.mit.edu	37	15	95019879	95019882	+	Intron	DEL	AGAC	-	-	rs28760289	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:95019879_95019882delAGAC	uc002btj.2	+						MCTP2_uc010boj.2_Intron|MCTP2_uc010bok.2_Intron|MCTP2_uc002btl.2_Intron	NM_018349	NP_060819			multiple C2 domains, transmembrane 2 isoform 1						calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)															---	---	---	---
Unknown	0	broad.mit.edu	37	15	96513434	96513434	+	IGR	DEL	A	-	-	rs147101321	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:96513434delA								LOC145820 (462360 upstream) : NR2F2 (355723 downstream)																																			---	---	---	---
MEF2A	4205	broad.mit.edu	37	15	100214570	100214570	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:100214570delT	uc010urw.1	+						MEF2A_uc010urv.1_Intron|MEF2A_uc010bos.2_Intron|MEF2A_uc002bvf.2_Intron|MEF2A_uc002bve.2_Intron|MEF2A_uc002bvg.2_Intron|MEF2A_uc002bvi.2_Intron|MEF2A_uc010bot.2_Intron	NM_005587	NP_005578			myocyte enhancer factor 2A isoform 1						apoptosis|BMK cascade|cardiac conduction|cellular response to calcium ion|dendrite morphogenesis|innate immune response|mitochondrial genome maintenance|mitochondrion distribution|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|ventricular cardiac myofibril development	nuclear chromatin|nucleoplasm	activating transcription factor binding|histone acetyltransferase binding|histone deacetylase binding|protein heterodimerization activity|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|SMAD binding			ovary(1)	1	Lung NSC(78;0.00335)|all_lung(78;0.00659)|Melanoma(26;0.00778)|Medulloblastoma(229;0.163)		OV - Ovarian serous cystadenocarcinoma(32;0.00085)															---	---	---	---
CHSY1	22856	broad.mit.edu	37	15	101719196	101719196	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:101719196delA	uc002bwt.1	-						CHSY1_uc010usd.1_Intron	NM_014918	NP_055733			chondroitin sulfate synthase 1						chondroitin sulfate biosynthetic process	Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity				0	Lung NSC(78;0.00217)|all_lung(78;0.00271)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)															---	---	---	---
LUC7L	55692	broad.mit.edu	37	16	240498	240498	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:240498delA	uc002cgc.1	-						LUC7L_uc002cga.1_Intron|LUC7L_uc002cgd.1_Intron|LUC7L_uc002cge.1_Intron|LUC7L_uc002cgb.1_Intron	NM_201412	NP_958815			LUC7-like isoform b								metal ion binding			central_nervous_system(1)	1		all_cancers(16;1.1e-06)|all_epithelial(16;2.71e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.0138)|all_lung(18;0.0306)																---	---	---	---
PIGQ	9091	broad.mit.edu	37	16	624018	624018	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:624018delG	uc002cho.2	+						PIGQ_uc010bqw.2_Intron|PIGQ_uc002chm.2_Intron|PIGQ_uc002chn.2_Intron|PIGQ_uc010uui.1_Intron	NM_148920	NP_683721			phosphatidylinositol glycan anchor biosynthesis,						C-terminal protein lipidation|carbohydrate metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			central_nervous_system(1)	1		Hepatocellular(780;0.00335)																---	---	---	---
WDR90	197335	broad.mit.edu	37	16	703327	703327	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:703327delC	uc002cii.1	+						WDR90_uc002cig.1_Intron|WDR90_uc002cih.1_Intron|WDR90_uc002cij.1_Intron|WDR90_uc002cik.1_5'Flank	NM_145294	NP_660337			WD repeat domain 90											ovary(1)	1		Hepatocellular(780;0.0218)																---	---	---	---
RHBDL1	9028	broad.mit.edu	37	16	727713	727713	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:727713delG	uc002cis.1	+						RHBDL1_uc002cir.1_Intron|RHBDL1_uc010uun.1_3'UTR|STUB1_uc002cit.2_5'Flank|STUB1_uc002ciu.2_5'Flank|STUB1_uc010bqz.2_5'Flank|STUB1_uc002civ.2_5'Flank	NM_003961	NP_003952			rhomboid protease 1						proteolysis|signal transduction	integral to plasma membrane|membrane fraction	calcium ion binding|serine-type endopeptidase activity				0		Hepatocellular(780;0.0218)																---	---	---	---
ABCA3	21	broad.mit.edu	37	16	2342075	2342075	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2342075delA	uc002cpy.1	-						ABCA3_uc010bsk.1_Intron|ABCA3_uc010bsl.1_Intron	NM_001089	NP_001080			ATP-binding cassette, sub-family A member 3						response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)																---	---	---	---
ABCA3	21	broad.mit.edu	37	16	2382235	2382235	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2382235delT	uc002cpy.1	-						ABCA3_uc010bsk.1_Intron|ABCA3_uc010bsl.1_Intron|ABCA3_uc002cpz.1_5'Flank	NM_001089	NP_001080			ATP-binding cassette, sub-family A member 3						response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)																---	---	---	---
CCNF	899	broad.mit.edu	37	16	2481116	2481117	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2481116_2481117insT	uc002cqd.1	+						CCNF_uc002cqe.1_Intron	NM_001761	NP_001752			cyclin F						cell division|mitosis|negative regulation of centrosome duplication|protein ubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	centriole|nucleus|SCF ubiquitin ligase complex	protein binding			central_nervous_system(1)|kidney(1)	2		Ovarian(90;0.17)																---	---	---	---
CCNF	899	broad.mit.edu	37	16	2495726	2495728	+	Intron	DEL	TGT	-	-	rs141290345	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2495726_2495728delTGT	uc002cqd.1	+						CCNF_uc002cqe.1_Intron	NM_001761	NP_001752			cyclin F						cell division|mitosis|negative regulation of centrosome duplication|protein ubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	centriole|nucleus|SCF ubiquitin ligase complex	protein binding			central_nervous_system(1)|kidney(1)	2		Ovarian(90;0.17)																---	---	---	---
MEFV	4210	broad.mit.edu	37	16	3299798	3299798	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3299798delA	uc002cun.1	-							NM_000243	NP_000234			Mediterranean fever protein						inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|lung(1)	6					Colchicine(DB01394)													---	---	---	---
CLUAP1	23059	broad.mit.edu	37	16	3569691	3569691	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3569691delA	uc002cvk.1	+						CLUAP1_uc002cvj.1_Intron|CLUAP1_uc002cvl.1_Intron|CLUAP1_uc002cvm.1_Intron	NM_015041	NP_055856			clusterin associated protein 1 isoform 1							nucleus	protein binding			ovary(1)|breast(1)|pancreas(1)	3																		---	---	---	---
ADCY9	115	broad.mit.edu	37	16	4027728	4027728	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:4027728delT	uc002cvx.2	-							NM_001116	NP_001107			adenylate cyclase 9						activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6																		---	---	---	---
SRL	6345	broad.mit.edu	37	16	4247598	4247598	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:4247598delT	uc002cvz.3	-						SRL_uc002cvy.3_Intron	NM_001098814	NP_001092284			sarcalumenin							sarcoplasmic reticulum lumen	GTP binding|GTPase activity			ovary(3)|skin(2)	5																		---	---	---	---
C16orf71	146562	broad.mit.edu	37	16	4788056	4788056	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:4788056delT	uc002cxn.2	+							NM_139170	NP_631909			hypothetical protein LOC146562											central_nervous_system(1)	1																		---	---	---	---
GLYR1	84656	broad.mit.edu	37	16	4896043	4896043	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:4896043delA	uc002cxx.3	-						GLYR1_uc002cxy.2_Intron|GLYR1_uc002cxz.1_Intron|GLYR1_uc002cya.2_Intron|GLYR1_uc010uxv.1_Intron|UBN1_uc010uxw.1_5'Flank|UBN1_uc002cyb.2_5'Flank	NM_032569	NP_115958			cytokine-like nuclear factor n-pac						pentose-phosphate shunt	nucleus	coenzyme binding|DNA binding|methylated histone residue binding|phosphogluconate dehydrogenase (decarboxylating) activity				0																		---	---	---	---
USP7	7874	broad.mit.edu	37	16	8994269	8994269	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:8994269delA	uc002czl.2	-						USP7_uc010uyk.1_Intron|USP7_uc002czj.2_Intron|USP7_uc010uyj.1_Intron|USP7_uc002czk.2_Intron	NM_003470	NP_003461			ubiquitin specific peptidase 7						interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)	3																		---	---	---	---
USP7	7874	broad.mit.edu	37	16	8994680	8994680	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:8994680delA	uc002czl.2	-						USP7_uc010uyk.1_Intron|USP7_uc002czj.2_Intron|USP7_uc010uyj.1_Intron|USP7_uc002czk.2_Intron	NM_003470	NP_003461			ubiquitin specific peptidase 7						interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)	3																		---	---	---	---
NUBP1	4682	broad.mit.edu	37	16	10851656	10851656	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:10851656delA	uc002daa.1	+						NUBP1_uc010bum.1_Intron|NUBP1_uc002dab.1_Intron	NM_002484	NP_002475			nucleotide binding protein 1						cell growth|cellular iron ion homeostasis|iron-sulfur cluster assembly	cytosol	4 iron, 4 sulfur cluster binding|ATP binding|metal ion binding|nucleoside-triphosphatase activity|protein binding			ovary(1)|skin(1)	2																		---	---	---	---
CLEC16A	23274	broad.mit.edu	37	16	11141159	11141159	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:11141159delT	uc002dao.2	+	17	2056	c.1826delT	c.(1825-1827)ATTfs	p.I609fs	CLEC16A_uc002dan.3_Frame_Shift_Del_p.I591fs	NM_015226	NP_056041	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	609										ovary(1)|central_nervous_system(1)	2																		---	---	---	---
C16orf75	116028	broad.mit.edu	37	16	11374581	11374581	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:11374581delC	uc002daq.1	+											Homo sapiens cDNA FLJ41770 fis, clone IMR322007225.						DNA replication	nucleus	DNA binding				0								T	CIITA	PMBL|Hodgkin Lymphona|								---	---	---	---
SNX29	92017	broad.mit.edu	37	16	12492571	12492572	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:12492571_12492572delTT	uc002dby.3	+							NM_001080530	NP_001073999			sorting nexin 29						cell communication		phosphatidylinositol binding			ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	16	12936326	12936326	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:12936326delT								CPPED1 (38582 upstream) : SHISA9 (59151 downstream)																																			---	---	---	---
MKL2	57496	broad.mit.edu	37	16	14312901	14312901	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:14312901delT	uc010uza.1	+						MKL2_uc002dcg.2_Intron|MKL2_uc002dch.2_Intron|MKL2_uc010uzb.1_Intron	NM_014048	NP_054767			megakaryoblastic leukemia 2 protein						cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			ovary(3)|kidney(1)|pancreas(1)	5																		---	---	---	---
PARN	5073	broad.mit.edu	37	16	14674917	14674917	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:14674917delT	uc010uzd.1	-						PARN_uc010uzc.1_Intron|PARN_uc010uze.1_Intron|PARN_uc010uzf.1_Intron	NM_002582	NP_002573			poly(A)-specific ribonuclease (deadenylation						female gamete generation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|RNA modification	cytosol|nucleolus	metal ion binding|mRNA 3'-UTR binding|nucleotide binding|poly(A)-specific ribonuclease activity|protein binding			ovary(2)	2																		---	---	---	---
MPV17L	255027	broad.mit.edu	37	16	15501606	15501606	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:15501606delA	uc002ddn.2	+						MPV17L_uc002ddm.2_Intron	NM_001128423	NP_001121895			MPV17 mitochondrial membrane protein-like							integral to membrane|peroxisomal membrane					0																		---	---	---	---
NDE1	54820	broad.mit.edu	37	16	15793752	15793752	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:15793752delT	uc010uzy.1	+						NDE1_uc002dds.2_Intron	NM_001143979	NP_001137451			nuclear distribution gene E homolog 1						cell differentiation|cell division|centrosome duplication|establishment of chromosome localization|establishment of mitotic spindle orientation|G2/M transition of mitotic cell cycle|mitotic prometaphase|nervous system development	cleavage furrow|condensed chromosome kinetochore|cytosol|microtubule|spindle pole centrosome	microtubule binding			ovary(1)	1																		---	---	---	---
MYH11	4629	broad.mit.edu	37	16	15880370	15880370	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:15880370delG	uc002ddy.2	-						MYH11_uc002ddv.2_Intron|MYH11_uc002ddw.2_Intron|MYH11_uc002ddx.2_Intron|MYH11_uc010bvg.2_Intron|MYH11_uc002dea.1_5'Flank|MYH11_uc002deb.3_3'UTR	NM_002474	NP_002465			smooth muscle myosin heavy chain 11 isoform						axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15								T	CBFB	AML								---	---	---	---
ABCC1	4363	broad.mit.edu	37	16	16165586	16165587	+	Splice_Site	INS	-	GT	GT			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:16165586_16165587insGT	uc010bvi.2	+	14	2087	c.1912_splice	c.e14+1	p.G638_splice	ABCC1_uc010bvj.2_Splice_Site_p.G638_splice|ABCC1_uc010bvk.2_Splice_Site_p.G638_splice|ABCC1_uc010bvl.2_Splice_Site_p.G638_splice|ABCC1_uc010bvm.2_Splice_Site_p.G638_splice|ABCC1_uc002del.3_Splice_Site_p.G522_splice	NM_004996	NP_004987			ATP-binding cassette, sub-family C, member 1						hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)													---	---	---	---
ARL6IP1	23204	broad.mit.edu	37	16	18810349	18810350	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:18810349_18810350delTT	uc002dfl.1	-						ARL6IP1_uc010van.1_Intron|ARL6IP1_uc010bvz.1_Intron	NM_015161	NP_055976			ADP-ribosylation factor-like 6 interacting							integral to membrane	protein binding				0																		---	---	---	---
GPRC5B	51704	broad.mit.edu	37	16	19873331	19873331	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:19873331delA	uc002dgt.2	-						GPRC5B_uc010vav.1_Intron	NM_016235	NP_057319			G protein-coupled receptor, family C, group 5,											lung(1)|breast(1)|skin(1)	3																		---	---	---	---
DNAH3	55567	broad.mit.edu	37	16	21145457	21145457	+	Intron	DEL	T	-	-	rs74724528		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:21145457delT	uc010vbe.1	-						DNAH3_uc002die.2_Intron	NM_017539	NP_060009			dynein, axonemal, heavy chain 3						ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)														---	---	---	---
ANKS4B	257629	broad.mit.edu	37	16	21262269	21262270	+	3'UTR	DEL	GA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:21262269_21262270delGA	uc010bwp.1	+	2					CRYM_uc010bwq.1_Intron	NM_145865	NP_665872			harmonin-interacting ankyrin-repeat containing											ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0565)														---	---	---	---
EARS2	124454	broad.mit.edu	37	16	23544150	23544150	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:23544150delT	uc002dlt.3	-						EARS2_uc002dlr.3_Intron|EARS2_uc002dls.3_Intron|EARS2_uc002dlu.2_Intron	NM_001083614	NP_001077083			glutamyl-tRNA synthetase 2 precursor						glutamyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|glutamate-tRNA ligase activity|RNA binding				0				GBM - Glioblastoma multiforme(48;0.0353)	L-Glutamic Acid(DB00142)													---	---	---	---
GTF3C1	2975	broad.mit.edu	37	16	27509762	27509762	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:27509762delT	uc002dov.1	-						GTF3C1_uc002dou.2_Intron	NM_001520	NP_001511			general transcription factor IIIC, polypeptide							transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5																		---	---	---	---
APOB48R	55911	broad.mit.edu	37	16	28508985	28508985	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:28508985delG	uc002dqb.1	+	3	2606	c.2596delG	c.(2596-2598)GGGfs	p.G866fs	uc010vct.1_Intron|APOB48R_uc010byg.1_Frame_Shift_Del_p.G404fs	NM_018690	NP_061160	Q0VD83	APOBR_HUMAN	apolipoprotein B48 receptor	866	Glu-rich.				cholesterol metabolic process|lipid transport	chylomicron|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle					0																		---	---	---	---
BOLA2	552900	broad.mit.edu	37	16	29636194	29636194	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:29636194delA	uc010bzb.1	-						uc002dtf.2_Intron					SubName: Full=Putative uncharacterized protein ENSP00000369970; Flags: Fragment;												0																		---	---	---	---
KIF22	3835	broad.mit.edu	37	16	29809531	29809531	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:29809531delT	uc002dts.3	+						uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|KIF22_uc010vdv.1_Intron|KIF22_uc010vdw.1_Intron|KIF22_uc010bzf.2_Intron	NM_007317	NP_015556			kinesin family member 22						blood coagulation|DNA repair|microtubule-based movement|mitosis	cytosol|kinetochore|microtubule|nucleus	ATP binding|DNA binding|microtubule motor activity|protein binding				0																		---	---	---	---
LOC595101	595101	broad.mit.edu	37	16	30291742	30291742	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:30291742delA	uc002dxp.1	-							NR_002453				Homo sapiens cDNA FLJ39663 fis, clone SMINT2007187.												0																		---	---	---	---
ZNF48	197407	broad.mit.edu	37	16	30409310	30409310	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:30409310delC	uc002dya.1	+	2	798	c.739delC	c.(739-741)CCCfs	p.P247fs	ZNF48_uc002dxz.1_Frame_Shift_Del_p.P124fs	NM_152652	NP_689865	Q96MX3	ZNF48_HUMAN	zinc finger protein 48	247					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
BCL7C	9274	broad.mit.edu	37	16	30899222	30899223	+	Frame_Shift_Ins	INS	-	G	G	rs150838242		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:30899222_30899223insG	uc002dzv.2	-	6	751_752	c.617_618insC	c.(616-618)CCAfs	p.P206fs	BCL7C_uc002dzt.1_Intron|uc002dzu.2_Intron	NM_004765	NP_004756	Q8WUZ0	BCL7C_HUMAN	B-cell CLL/lymphoma 7C	206	Pro-rich.				apoptosis						0			Colorectal(24;0.198)															---	---	---	---
PRSS53	339105	broad.mit.edu	37	16	31106664	31106665	+	5'Flank	DEL	AG	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:31106664_31106665delAG	uc002ear.2	-						VKORC1_uc002eas.2_5'Flank|VKORC1_uc002eat.2_5'Flank|VKORC1_uc002eau.2_5'Flank	NM_001039503	NP_001034592			polyserase 3 precursor						proteolysis	extracellular region	serine-type endopeptidase activity				0																		---	---	---	---
PRSS36	146547	broad.mit.edu	37	16	31151942	31151942	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:31151942delG	uc002ebd.2	-	13	2097	c.2038delC	c.(2038-2040)CTGfs	p.L680fs	PRSS36_uc010vff.1_Frame_Shift_Del_p.L455fs|PRSS36_uc010vfg.1_Frame_Shift_Del_p.L675fs|PRSS36_uc010vfh.1_Intron	NM_173502	NP_775773	Q5K4E3	POLS2_HUMAN	protease, serine, 36 precursor	680	Peptidase S1 3.				proteolysis	cytoplasm|proteinaceous extracellular matrix	serine-type endopeptidase activity			ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	16	33014059	33014059	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:33014059delA								SLC6A10P (117596 upstream) : MIR1826 (951449 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	16	34723667	34723667	+	IGR	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:34723667delC								LOC146481 (8700 upstream) : None (None downstream)																																			---	---	---	---
ITFG1	81533	broad.mit.edu	37	16	47292700	47292700	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:47292700delA	uc002eet.2	-						ITFG1_uc010vgg.1_Intron|ITFG1_uc010vgh.1_Intron	NM_030790	NP_110417			integrin alpha FG-GAP repeat containing 1							extracellular region|integral to membrane				ovary(1)|central_nervous_system(1)	2		all_cancers(37;0.0613)|all_lung(18;0.0543)|Lung NSC(13;0.227)																---	---	---	---
ITFG1	81533	broad.mit.edu	37	16	47485385	47485385	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:47485385delA	uc002eet.2	-						ITFG1_uc010vgh.1_Intron|ITFG1_uc010cbf.1_Intron	NM_030790	NP_110417			integrin alpha FG-GAP repeat containing 1							extracellular region|integral to membrane				ovary(1)|central_nervous_system(1)	2		all_cancers(37;0.0613)|all_lung(18;0.0543)|Lung NSC(13;0.227)																---	---	---	---
PHKB	5257	broad.mit.edu	37	16	47730282	47730282	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:47730282delT	uc002eev.3	+						PHKB_uc002eeu.3_Intron|PHKB_uc002eew.3_Intron	NM_000293	NP_000284			phosphorylase kinase, beta isoform a						glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity			ovary(1)|large_intestine(1)|breast(1)	3		all_cancers(37;0.00447)|all_lung(18;0.00616)|Lung NSC(13;0.0418)|Breast(268;0.203)																---	---	---	---
HEATR3	55027	broad.mit.edu	37	16	50106493	50106493	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:50106493delT	uc002efw.2	+						HEATR3_uc002efx.2_Intron	NM_182922	NP_891552			HEAT repeat containing 3								binding			ovary(1)|skin(1)	2																		---	---	---	---
SALL1	6299	broad.mit.edu	37	16	51185193	51185193	+	5'Flank	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:51185193delA	uc010vgs.1	-						SALL1_uc010vgr.1_5'Flank|SALL1_uc010cbv.2_5'Flank	NM_002968	NP_002959			sal-like 1 isoform a						adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)															---	---	---	---
CHD9	80205	broad.mit.edu	37	16	53326632	53326633	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:53326632_53326633delTT	uc002ehb.2	+						CHD9_uc002egy.2_Intron|CHD9_uc002ehc.2_Intron|CHD9_uc002ehf.2_Intron|CHD9_uc010cbw.2_Intron	NM_025134	NP_079410			chromodomain helicase DNA binding protein 9						cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)																---	---	---	---
RBL2	5934	broad.mit.edu	37	16	53515565	53515565	+	Intron	DEL	T	-	-	rs72027669		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:53515565delT	uc002ehi.3	+						RBL2_uc002ehj.2_Intron|RBL2_uc010vgw.1_Intron	NM_005611	NP_005602			retinoblastoma-like 2 (p130)						cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5																		---	---	---	---
IRX3	79191	broad.mit.edu	37	16	54319087	54319087	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:54319087delC	uc002eht.1	-	2	1122	c.706delG	c.(706-708)GAGfs	p.E236fs		NM_024336	NP_077312	P78415	IRX3_HUMAN	iroquois homeobox 3	236	Asp/Glu-rich (acidic).				multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0																		---	---	---	---
LPCAT2	54947	broad.mit.edu	37	16	55579807	55579807	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:55579807delT	uc002eie.3	+						LPCAT2_uc002eic.2_Intron	NM_017839	NP_060309			lysophosphatidylcholine acyltransferase 2						cellular membrane organization|platelet activating factor biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|Golgi stack|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding				0																		---	---	---	---
SLC6A2	6530	broad.mit.edu	37	16	55730393	55730393	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:55730393delA	uc002eif.2	+						SLC6A2_uc010ccd.2_Intron|SLC6A2_uc002eig.2_Intron|SLC6A2_uc002eih.2_Intron|SLC6A2_uc002eii.2_Intron|SLC6A2_uc002eij.2_Intron	NM_001043	NP_001034			solute carrier family 6 member 2						synaptic transmission	integral to plasma membrane|membrane fraction	norepinephrine:sodium symporter activity			lung(4)|ovary(2)|pancreas(2)	8				BRCA - Breast invasive adenocarcinoma(181;0.01)|Kidney(780;0.0267)	Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Atomoxetine(DB00289)|Bethanidine(DB00217)|Bupropion(DB01156)|Clomipramine(DB01242)|Cocaine(DB00907)|Debrisoquin(DB04840)|Desipramine(DB01151)|Diethylpropion(DB00937)|Doxepin(DB01142)|Duloxetine(DB00476)|Ergotamine(DB00696)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Imipramine(DB00458)|Maprotiline(DB00934)|Mazindol(DB00579)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Protriptyline(DB00344)|Reboxetine(DB00234)|Sibutramine(DB01105)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)													---	---	---	---
FAM192A	80011	broad.mit.edu	37	16	57206437	57206437	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:57206437delA	uc010vhk.1	-						FAM192A_uc002ekz.3_Intron|FAM192A_uc002ekv.3_Intron|FAM192A_uc002ekw.3_Intron|FAM192A_uc002ekx.3_Intron|FAM192A_uc002eky.3_Intron|FAM192A_uc010ccx.2_Intron	NM_024946	NP_079222			NEFA-interacting nuclear protein NIP30							nucleus					0																		---	---	---	---
CX3CL1	6376	broad.mit.edu	37	16	57416105	57416105	+	Frame_Shift_Del	DEL	G	-	-	rs147669719		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:57416105delG	uc002eli.2	+	3	422	c.355delG	c.(355-357)GGGfs	p.G119fs		NM_002996	NP_002987	P78423	X3CL1_HUMAN	chemokine (C-X3-C motif) ligand 1 precursor	119	Mucin-like stalk.|Extracellular (Potential).				cell adhesion|cytokine-mediated signaling pathway|defense response|immune response|leukocyte adhesive activation|positive regulation of calcium-independent cell-cell adhesion|positive regulation of inflammatory response	cell surface|extracellular space|integral to membrane|plasma membrane	chemokine activity				0																		---	---	---	---
KATNB1	10300	broad.mit.edu	37	16	57788697	57788698	+	Intron	INS	-	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:57788697_57788698insC	uc002eml.1	+							NM_005886	NP_005877			katanin p80 subunit B 1						cell division|mitosis|negative regulation of microtubule depolymerization|positive regulation of microtubule depolymerization|protein targeting	katanin complex|microtubule|spindle pole	microtubule binding|protein heterodimerization activity				0		all_neural(199;0.223)																---	---	---	---
C16orf57	79650	broad.mit.edu	37	16	58048101	58048101	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:58048101delT	uc002emz.2	+						C16orf57_uc010vib.1_Intron	NM_024598	NP_078874			hypothetical protein LOC79650												0																		---	---	---	---
CNOT1	23019	broad.mit.edu	37	16	58587613	58587613	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:58587613delA	uc002env.2	-						CNOT1_uc002enw.2_Intron|CNOT1_uc002enu.3_Intron|CNOT1_uc002enx.2_Intron|CNOT1_uc002enz.1_Intron|CNOT1_uc010vik.1_5'Flank	NM_016284	NP_057368			CCR4-NOT transcription complex, subunit 1						nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)														---	---	---	---
Unknown	0	broad.mit.edu	37	16	59590649	59590649	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:59590649delT								GOT2 (822403 upstream) : None (None downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	16	60214879	60214890	+	IGR	DEL	TTTTTTCTTTCT	-	-	rs61127820	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:60214879_60214890delTTTTTTCTTTCT								None (None upstream) : None (None downstream)																																			---	---	---	---
CDH8	1006	broad.mit.edu	37	16	61689778	61689780	+	Intron	DEL	TTT	-	-	rs66728481		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:61689778_61689780delTTT	uc002eog.1	-							NM_001796	NP_001787			cadherin 8, type 2 preproprotein						adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)														---	---	---	---
NAE1	8883	broad.mit.edu	37	16	66855469	66855470	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:66855469_66855470delAA	uc002eqf.2	-						NAE1_uc002eqe.2_Intron|NAE1_uc002eqg.2_Intron|NAE1_uc010cdv.2_Intron|NAE1_uc010cdw.1_Intron	NM_003905	NP_003896			NEDD8 activating enzyme E1 subunit 1 isoform a						apoptosis|cell cycle|DNA replication|mitotic cell cycle DNA replication checkpoint|protein neddylation|signal transduction	cytoplasm|insoluble fraction|plasma membrane	catalytic activity|protein heterodimerization activity			ovary(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0914)|Epithelial(162;0.214)	Adenosine triphosphate(DB00171)													---	---	---	---
CBFB	865	broad.mit.edu	37	16	67116033	67116036	+	Intron	DEL	AAAA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67116033_67116036delAAAA	uc002era.2	+						CBFB_uc002erb.2_Intron|CBFB_uc010vja.1_Intron	NM_001755	NP_001746			core-binding factor, beta subunit isoform 2						transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)	2		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00189)|Epithelial(162;0.00755)|all cancers(182;0.066)				T	MYH11	AML								---	---	---	---
KCTD19	146212	broad.mit.edu	37	16	67331704	67331704	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67331704delT	uc002esu.2	-						KCTD19_uc002est.2_Intron|KCTD19_uc010vjj.1_Intron	NM_001100915	NP_001094385			potassium channel tetramerisation domain							voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)														---	---	---	---
KCTD19	146212	broad.mit.edu	37	16	67342074	67342075	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67342074_67342075delTT	uc002esu.2	-						KCTD19_uc002est.2_Intron|KCTD19_uc010vjj.1_Intron	NM_001100915	NP_001094385			potassium channel tetramerisation domain							voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)														---	---	---	---
SLC12A4	6560	broad.mit.edu	37	16	67980644	67980644	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67980644delG	uc002euz.2	-						LCAT_uc002euy.1_5'Flank|SLC12A4_uc010ceu.2_Intron|SLC12A4_uc010vkh.1_Intron|SLC12A4_uc010vki.1_Intron|SLC12A4_uc010vkj.1_Intron|SLC12A4_uc002eva.2_Intron|SLC12A4_uc010cev.1_Intron	NM_005072	NP_005063			solute carrier family 12, member 4 isoform a						cell volume homeostasis|potassium ion transport|sodium ion transport	integral to plasma membrane|membrane fraction	potassium:chloride symporter activity			ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)	Bumetanide(DB00887)|Potassium Chloride(DB00761)													---	---	---	---
PLA2G15	23659	broad.mit.edu	37	16	68279440	68279440	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:68279440delC	uc002evr.2	+	1	194	c.111delC	c.(109-111)CACfs	p.H37fs	PLA2G15_uc010vld.1_Frame_Shift_Del_p.H37fs|PLA2G15_uc010vle.1_Frame_Shift_Del_p.H37fs|PLA2G15_uc010vlf.1_Frame_Shift_Del_p.H37fs	NM_012320	NP_036452	Q8NCC3	PAG15_HUMAN	lysophospholipase 3 (lysosomal phospholipase A2)	37					fatty acid catabolic process	extracellular region|lysosome	lysophospholipase activity|phosphatidylcholine-sterol O-acyltransferase activity|phospholipid binding			ovary(1)	1																		---	---	---	---
SLC7A6	9057	broad.mit.edu	37	16	68335453	68335453	+	3'UTR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:68335453delT	uc002evt.1	+	12					SLC7A6_uc002evu.1_3'UTR|SLC7A6_uc002evv.1_RNA|SLC7A6_uc010cfc.1_RNA|SLC7A6OS_uc002evw.1_Intron	NM_001076785	NP_001070253			solute carrier family 7 (cationic amino acid						blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	basolateral plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|antiporter activity			central_nervous_system(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.034)|Epithelial(162;0.0948)														---	---	---	---
SMPD3	55512	broad.mit.edu	37	16	68397781	68397781	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:68397781delG	uc002ewa.2	-						SMPD3_uc010cfe.2_Intron|SMPD3_uc010vlh.1_Intron	NM_018667	NP_061137			neutral sphingomyelin phosphodiesterase 3						cell cycle|multicellular organismal development|sphingomyelin catabolic process	Golgi membrane|integral to membrane|plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity			skin(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0184)|Epithelial(162;0.0785)	Phosphatidylserine(DB00144)													---	---	---	---
TMCO7	79613	broad.mit.edu	37	16	68952818	68952818	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:68952818delA	uc002ewi.3	+							NM_024562	NP_078838			transmembrane and coiled-coil domains 7							integral to membrane	binding				0		Ovarian(137;0.0568)		OV - Ovarian serous cystadenocarcinoma(108;0.0446)|Epithelial(162;0.198)														---	---	---	---
CIRH1A	84916	broad.mit.edu	37	16	69196806	69196807	+	Intron	INS	-	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:69196806_69196807insG	uc002ews.3	+						CIRH1A_uc002ewr.2_Intron|CIRH1A_uc002ewt.3_Intron|CIRH1A_uc010cfi.2_Intron	NM_032830	NP_116219			cirhin							nucleolus	protein binding				0				OV - Ovarian serous cystadenocarcinoma(108;0.125)														---	---	---	---
SNTB2	6645	broad.mit.edu	37	16	69317980	69317980	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:69317980delC	uc002ewu.2	+	5	1198	c.1178delC	c.(1177-1179)TCCfs	p.S393fs		NM_006750	NP_006741	Q13425	SNTB2_HUMAN	basic beta 2 syntrophin	393	PH 2.					cell junction|dystrophin-associated glycoprotein complex|membrane fraction|microtubule|transport vesicle membrane	actin binding|calmodulin binding|protein binding				0		Ovarian(137;0.101)		OV - Ovarian serous cystadenocarcinoma(108;0.208)														---	---	---	---
NFAT5	10725	broad.mit.edu	37	16	69710992	69710992	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:69710992delT	uc002exm.1	+						NFAT5_uc002exh.1_Intron|NFAT5_uc002exi.2_Intron|NFAT5_uc002exj.1_Intron|NFAT5_uc002exk.1_Intron|NFAT5_uc002exl.1_Intron|NFAT5_uc002exn.1_Intron	NM_006599	NP_006590			nuclear factor of activated T-cells 5 isoform c						excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0																		---	---	---	---
NOB1	28987	broad.mit.edu	37	16	69785968	69785968	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:69785968delA	uc002exs.2	-							NM_014062	NP_054781			nin one binding protein							nucleus	metal ion binding|protein binding				0																		---	---	---	---
CLEC18C	283971	broad.mit.edu	37	16	70030143	70030143	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:70030143delA	uc002exy.2	+						PDXDC2_uc002eyb.2_Intron|PDXDC2_uc002eyc.2_Intron	NM_182619	NP_872425			secretory protein LOC348174 precursor							extracellular region	sugar binding				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	16	70268054	70268056	+	Intron	DEL	AAA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:70268054_70268056delAAA	uc010cfp.1	-											Homo sapiens cDNA, FLJ98908.																														---	---	---	---
COG4	25839	broad.mit.edu	37	16	70548110	70548110	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:70548110delA	uc002ezc.2	-						COG4_uc010cfu.2_Intron|COG4_uc002ezd.2_Intron|COG4_uc002eze.2_Intron	NM_015386	NP_056201			component of oligomeric golgi complex 4						Golgi organization|Golgi vesicle prefusion complex stabilization|protein transport|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding				0		Ovarian(137;0.0694)																---	---	---	---
SF3B3	23450	broad.mit.edu	37	16	70566261	70566262	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:70566261_70566262delAA	uc002ezf.2	+							NM_012426	NP_036558			splicing factor 3b, subunit 3						protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(1)	1		Ovarian(137;0.0694)																---	---	---	---
SF3B3	23450	broad.mit.edu	37	16	70605544	70605544	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:70605544delT	uc002ezf.2	+							NM_012426	NP_036558			splicing factor 3b, subunit 3						protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(1)	1		Ovarian(137;0.0694)																---	---	---	---
IL34	146433	broad.mit.edu	37	16	70690422	70690422	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:70690422delA	uc002ezh.1	+						IL34_uc002ezi.1_Intron	NM_152456	NP_689669			interleukin 34 precursor						positive regulation of cell proliferation|positive regulation of protein phosphorylation	extracellular space	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding			central_nervous_system(1)|skin(1)	2																		---	---	---	---
MTSS1L	92154	broad.mit.edu	37	16	70714812	70714812	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:70714812delG	uc002ezj.2	-						MTSS1L_uc002ezk.1_5'Flank	NM_138383	NP_612392			metastasis suppressor 1-like						filopodium assembly|signal transduction		actin binding|cytoskeletal adaptor activity|SH3 domain binding			central_nervous_system(1)	1																		---	---	---	---
AP1G1	164	broad.mit.edu	37	16	71766876	71766877	+	3'UTR	INS	-	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:71766876_71766877insG	uc010cgg.2	-	23					AP1G1_uc002fba.2_3'UTR|AP1G1_uc002fbb.2_3'UTR|AP1G1_uc002faz.2_3'UTR	NM_001128	NP_001119			adaptor-related protein complex 1, gamma 1						endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity			ovary(2)	2		Ovarian(137;0.125)																---	---	---	---
KARS	3735	broad.mit.edu	37	16	75670510	75670510	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:75670510delA	uc002feq.2	-						KARS_uc002fer.2_Intron|KARS_uc002fes.2_Intron|KARS_uc010cgz.2_Intron	NM_005548	NP_005539			lysyl-tRNA synthetase isoform 2						interspecies interaction between organisms|lysyl-tRNA aminoacylation|tRNA processing	cytosol|extracellular region|mitochondrial matrix|nucleus|plasma membrane|soluble fraction	ATP binding|lysine-tRNA ligase activity|metal ion binding|tRNA binding			ovary(2)	2					L-Lysine(DB00123)													---	---	---	---
VAT1L	57687	broad.mit.edu	37	16	77850683	77850683	+	Intron	DEL	A	-	-	rs71884745		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:77850683delA	uc002ffg.1	+							NM_020927	NP_065978			vesicle amine transport protein 1 homolog (T.								oxidoreductase activity|zinc ion binding			central_nervous_system(1)	1																		---	---	---	---
CENPN	55839	broad.mit.edu	37	16	81045858	81045858	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:81045858delA	uc002ffx.2	+						CENPN_uc002ffw.3_Intron|CENPN_uc010vnl.1_Intron|CENPN_uc010vnm.1_Intron|CENPN_uc002ffy.3_Intron	NM_001100624	NP_001094094			centromere protein N isoform 2						CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm					0																		---	---	---	---
CENPN	55839	broad.mit.edu	37	16	81051116	81051116	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:81051116delA	uc002ffx.2	+						CENPN_uc002ffw.3_Intron|CENPN_uc010vnl.1_Intron|CENPN_uc010vnm.1_Intron|CENPN_uc002ffy.3_Intron	NM_001100624	NP_001094094			centromere protein N isoform 2						CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm					0																		---	---	---	---
C16orf46	123775	broad.mit.edu	37	16	81095915	81095915	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:81095915delA	uc002fgc.3	-						C16orf46_uc010chf.2_Intron|C16orf46_uc010vno.1_Intron	NM_152337	NP_689550			chromosome 16 open reading frame 46 isoform 2												0																		---	---	---	---
BCMO1	53630	broad.mit.edu	37	16	81295523	81295523	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:81295523delT	uc002fgn.1	+						BCMO1_uc002fgm.1_Intron|BCMO1_uc010vnp.1_Intron	NM_017429	NP_059125			beta-carotene 15,15'-monooxygenase						retinoid metabolic process|steroid metabolic process	cytosol	beta-carotene 15,15'-monooxygenase activity|metal ion binding|monooxygenase activity				0																		---	---	---	---
HSDL1	83693	broad.mit.edu	37	16	84165089	84165092	+	Intron	DEL	TCTA	-	-	rs36192181	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:84165089_84165092delTCTA	uc002fhk.2	-						HSDL1_uc010vnv.1_Intron	NM_031463	NP_113651			hydroxysteroid dehydrogenase like 1 isoform a							mitochondrion	oxidoreductase activity|protein binding				0																		---	---	---	---
ZDHHC7	55625	broad.mit.edu	37	16	85010039	85010039	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:85010039delG	uc002fiq.2	-	8	1190	c.837delC	c.(835-837)CCCfs	p.P279fs	ZDHHC7_uc010voi.1_Frame_Shift_Del_p.P316fs|ZDHHC7_uc002fir.1_RNA	NM_017740	NP_060210	Q9NXF8	ZDHC7_HUMAN	zinc finger, DHHC-type containing 7 isoform 2	279						integral to membrane	acyltransferase activity|protein binding|zinc ion binding			large_intestine(1)	1																		---	---	---	---
KLHDC4	54758	broad.mit.edu	37	16	87742157	87742157	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:87742157delG	uc002fki.2	-						LOC100129637_uc002fkg.2_5'Flank|LOC100129637_uc002fke.2_5'Flank|KLHDC4_uc002fkh.1_Intron|KLHDC4_uc010cht.1_Intron|KLHDC4_uc002fkj.2_Intron|KLHDC4_uc002fkk.2_Intron|KLHDC4_uc002fkl.2_Intron	NM_017566	NP_060036			kelch domain containing 4											pancreas(2)	2				BRCA - Breast invasive adenocarcinoma(80;0.0283)														---	---	---	---
KLHDC4	54758	broad.mit.edu	37	16	87764100	87764100	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:87764100delA	uc002fki.2	-						KLHDC4_uc010cht.1_Intron|KLHDC4_uc002fkj.2_Intron|KLHDC4_uc002fkk.2_Intron|KLHDC4_uc002fkl.2_Intron|KLHDC4_uc010chu.1_Intron	NM_017566	NP_060036			kelch domain containing 4											pancreas(2)	2				BRCA - Breast invasive adenocarcinoma(80;0.0283)														---	---	---	---
Unknown	0	broad.mit.edu	37	16	88620069	88620072	+	IGR	DEL	CCCA	-	-	rs2340958		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:88620069_88620072delCCCA								ZFPM1 (18496 upstream) : ZC3H18 (16717 downstream)																																			---	---	---	---
SNAI3	333929	broad.mit.edu	37	16	88752673	88752674	+	Intron	DEL	CT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:88752673_88752674delCT	uc002flj.2	-						MGC23284_uc002fli.3_Intron	NM_178310	NP_840101			snail homolog 3						oxidation-reduction process		copper ion binding|DNA binding|zinc ion binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.048)														---	---	---	---
PRPF8	10594	broad.mit.edu	37	17	1581125	1581125	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:1581125delA	uc002fte.2	-							NM_006445	NP_006436			U5 snRNP-specific protein							catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			lung(4)|ovary(2)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)														---	---	---	---
PAFAH1B1	5048	broad.mit.edu	37	17	2568632	2568632	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:2568632delT	uc002fuw.3	+						PAFAH1B1_uc010ckb.1_Intron	NM_000430	NP_000421			platelet-activating factor acetylhydrolase,						acrosome assembly|actin cytoskeleton organization|adult locomotory behavior|brain morphogenesis|corpus callosum morphogenesis|establishment of mitotic spindle orientation|G2/M transition of mitotic cell cycle|hippocampus development|layer formation in cerebral cortex|learning or memory|lipid catabolic process|microtubule organizing center organization|mitotic prometaphase|neuroblast proliferation|neuromuscular process controlling balance|neuron migration|platelet activating factor metabolic process|regulation of Rho GTPase activity|retrograde axon cargo transport|synaptic transmission|vesicle transport along microtubule	astral microtubule|cell cortex|centrosome|cytosol|kinetochore|motile primary cilium|nuclear membrane|perinuclear region of cytoplasm	dynactin binding|heparin binding|microtubule binding|phospholipase binding|phosphoprotein binding|protein homodimerization activity			skin(1)	1																		---	---	---	---
SHPK	23729	broad.mit.edu	37	17	3523247	3523248	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:3523247_3523248insA	uc002fvz.1	-							NM_013276	NP_037408			carbohydrate kinase-like						carbohydrate metabolic process	cytoplasm	ATP binding|sedoheptulokinase activity			ovary(1)	1				COAD - Colon adenocarcinoma(5;0.0828)														---	---	---	---
SHPK	23729	broad.mit.edu	37	17	3524895	3524896	+	Intron	INS	-	TCCC	TCCC			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:3524895_3524896insTCCC	uc002fvz.1	-							NM_013276	NP_037408			carbohydrate kinase-like						carbohydrate metabolic process	cytoplasm	ATP binding|sedoheptulokinase activity			ovary(1)	1				COAD - Colon adenocarcinoma(5;0.0828)														---	---	---	---
ZZEF1	23140	broad.mit.edu	37	17	3935310	3935311	+	Intron	INS	-	A	A	rs111443292		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:3935310_3935311insA	uc002fxe.2	-						ZZEF1_uc002fxh.2_Intron|ZZEF1_uc002fxi.2_Intron	NM_015113	NP_055928			zinc finger, ZZ type with EF hand domain 1								calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4																		---	---	---	---
ZZEF1	23140	broad.mit.edu	37	17	3967494	3967495	+	Intron	DEL	AA	-	-	rs112787658		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:3967494_3967495delAA	uc002fxe.2	-						ZZEF1_uc002fxh.2_5'Flank|ZZEF1_uc002fxi.2_Intron|ZZEF1_uc002fxj.1_Intron	NM_015113	NP_055928			zinc finger, ZZ type with EF hand domain 1								calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4																		---	---	---	---
SPNS3	201305	broad.mit.edu	37	17	4350102	4350102	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:4350102delG	uc002fxt.2	+						SPNS3_uc002fxu.2_Intron	NM_182538	NP_872344			spinster homolog 3						lipid transport|transmembrane transport	integral to membrane				large_intestine(1)	1																		---	---	---	---
ENO3	2027	broad.mit.edu	37	17	4857193	4857193	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:4857193delG	uc002gab.3	+						ENO3_uc010vsr.1_Intron|ENO3_uc002gac.3_Intron|ENO3_uc010vss.1_Intron|ENO3_uc010vst.1_Intron	NM_053013	NP_443739			enolase 3						gluconeogenesis|glycolysis	phosphopyruvate hydratase complex	magnesium ion binding|phosphopyruvate hydratase activity			ovary(1)	1																		---	---	---	---
FAM64A	54478	broad.mit.edu	37	17	6350599	6350599	+	Intron	DEL	T	-	-	rs113827676		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:6350599delT	uc002gcw.1	+						FAM64A_uc002gct.1_Intron|FAM64A_uc002gcu.1_Intron|FAM64A_uc002gcv.1_Intron|FAM64A_uc002gcx.1_Intron|FAM64A_uc002gcy.1_Intron|FAM64A_uc002gcz.1_Intron|FAM64A_uc002gda.1_Intron|FAM64A_uc002gdb.1_Intron	NM_019013	NP_061886			family with sequence similarity 64, member A							nucleolus	protein binding				0				COAD - Colon adenocarcinoma(228;0.141)														---	---	---	---
Unknown	0	broad.mit.edu	37	17	6563141	6563154	+	IGR	DEL	TCTCTCTCTCTCCT	-	-	rs146987408	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:6563141_6563154delTCTCTCTCTCTCCT								C17orf100 (6524 upstream) : SLC13A5 (24887 downstream)																																			---	---	---	---
WRAP53	55135	broad.mit.edu	37	17	7603866	7603866	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7603866delA	uc010vuh.1	+						WRAP53_uc010vui.1_Intron|WRAP53_uc002gip.2_Intron|WRAP53_uc002gir.2_Intron|WRAP53_uc002giq.2_Intron|WRAP53_uc010cnl.2_Intron|WRAP53_uc010vuj.1_5'Flank	NM_001143990	NP_001137462			WD repeat domain 79 isoform 2						positive regulation of telomerase activity|telomere formation via telomerase	Cajal body|cytoplasm|telomerase holoenzyme complex	protein binding|RNA binding				0																		---	---	---	---
DNAH2	146754	broad.mit.edu	37	17	7658285	7658287	+	Intron	DEL	AAA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7658285_7658287delAAA	uc002giu.1	+							NM_020877	NP_065928			dynein heavy chain domain 3						ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)																---	---	---	---
DNAH2	146754	broad.mit.edu	37	17	7667784	7667785	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7667784_7667785delTT	uc002giu.1	+							NM_020877	NP_065928			dynein heavy chain domain 3						ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)																---	---	---	---
PER1	5187	broad.mit.edu	37	17	8050889	8050889	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:8050889delG	uc002gkd.2	-	12	1634	c.1396delC	c.(1396-1398)CTGfs	p.L466fs	PER1_uc010vuq.1_RNA|PER1_uc010vur.1_Frame_Shift_Del_p.L450fs	NM_002616	NP_002607	O15534	PER1_HUMAN	period 1	466					circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			lung(2)|breast(2)|skin(2)|large_intestine(1)|ovary(1)|kidney(1)	9								T	ETV6	AML|CMML			Other_conserved_DNA_damage_response_genes					---	---	---	---
MYH10	4628	broad.mit.edu	37	17	8387385	8387385	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:8387385delT	uc002gll.2	-						MYH10_uc002glm.2_Intron|MYH10_uc010cnx.2_Intron	NM_005964	NP_005955			myosin, heavy polypeptide 10, non-muscle						actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2																		---	---	---	---
GLP2R	9340	broad.mit.edu	37	17	9729616	9729616	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:9729616delT	uc002gmd.1	+						GLP2R_uc010cog.1_Intron	NM_004246	NP_004237			glucagon-like peptide 2 receptor precursor						G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of cell proliferation	integral to membrane|plasma membrane				lung(2)|ovary(1)	3					Glucagon recombinant(DB00040)													---	---	---	---
C17orf48	56985	broad.mit.edu	37	17	10609714	10609714	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:10609714delA	uc002gmt.2	+						C17orf48_uc002gmu.2_Intron|C17orf48_uc002gmv.2_Intron|C17orf48_uc010vvg.1_Intron	NM_020233	NP_064618			ADP-ribose/CDP-alcohol pyrophosphatase								ADP-ribose diphosphatase activity|CDP-glycerol diphosphatase activity|metal ion binding				0																		---	---	---	---
MYOCD	93649	broad.mit.edu	37	17	12663850	12663850	+	Intron	DEL	A	-	-	rs74445886		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:12663850delA	uc002gnn.2	+						MYOCD_uc002gno.2_Intron|MYOCD_uc002gnq.2_Intron	NM_153604	NP_705832			myocardin isoform 2						cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)														---	---	---	---
Unknown	0	broad.mit.edu	37	17	14608345	14608345	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:14608345delT								HS3ST3B1 (358853 upstream) : PMP22 (524752 downstream)																																			---	---	---	---
TRIM16	10626	broad.mit.edu	37	17	15508389	15508389	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:15508389delA	uc002gor.1	-						CDRT1_uc002gov.3_Intron|CDRT1_uc002gou.2_Intron					SubName: Full=Putative uncharacterized protein; Flags: Fragment;						histone H3 acetylation|histone H4 acetylation|positive regulation of interleukin-1 beta secretion|positive regulation of keratinocyte differentiation|positive regulation of retinoic acid receptor signaling pathway|positive regulation of transcription, DNA-dependent|response to growth hormone stimulus|response to organophosphorus|response to retinoic acid	cytoplasm|plasma membrane|PML body	DNA binding|interleukin-1 binding|NACHT domain binding|zinc ion binding			ovary(2)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (92;0.0839)|Epithelial(1;8.4e-29)|all cancers(1;3.06e-28)|Colorectal(1;1.57e-19)|OV - Ovarian serous cystadenocarcinoma(1;6.1e-17)|COAD - Colon adenocarcinoma(1;3.38e-12)|READ - Rectum adenocarcinoma(2;1.46e-05)|BRCA - Breast invasive adenocarcinoma(8;0.0559)														---	---	---	---
FBXW10	10517	broad.mit.edu	37	17	18673620	18673620	+	Intron	DEL	T	-	-	rs67319828		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:18673620delT	uc002guk.2	+						FBXW10_uc002guj.2_Intron|FBXW10_uc002gul.2_Intron|FBXW10_uc010cqh.1_Intron	NM_031456	NP_113644			F-box and WD-40 domain protein 10											ovary(1)	1																		---	---	---	---
SLC5A10	125206	broad.mit.edu	37	17	18874258	18874258	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:18874258delG	uc002guu.1	+						SLC5A10_uc002gur.1_Intron|SLC5A10_uc002gut.1_Intron|SLC5A10_uc002guv.1_Intron|SLC5A10_uc010vyl.1_Intron	NM_001042450	NP_001035915			solute carrier family 5 (sodium/glucose						sodium ion transport|transmembrane transport	integral to membrane	transporter activity			ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	17	18988562	18988563	+	IGR	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:18988562_18988563delTT								GRAP (38226 upstream) : GRAPL (42219 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	17	19349228	19349228	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:19349228delT								RNF112 (28641 upstream) : SLC47A1 (87939 downstream)																																			---	---	---	---
CYTSB	92521	broad.mit.edu	37	17	20209172	20209172	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:20209172delT	uc002gwq.2	+						CYTSB_uc002gws.2_Intron|CYTSB_uc002gwv.2_Intron|CYTSB_uc010vzf.1_Intron|CYTSB_uc002gww.2_Intron	NM_001033553	NP_001028725			spectrin domain with coiled-coils 1 NSP5b3b							nucleus					0																		---	---	---	---
CCDC144C	348254	broad.mit.edu	37	17	20261134	20261134	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:20261134delT	uc010cqy.1	+							NR_023380				Homo sapiens cDNA FLJ59693 complete cds, moderately similar to Ankyrin repeat domain-containing protein 26.												0																		---	---	---	---
USP22	23326	broad.mit.edu	37	17	20921190	20921190	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:20921190delT	uc002gym.3	-						USP22_uc002gyn.3_Intron|USP22_uc002gyl.3_Intron	NM_015276	NP_056091			ubiquitin thiolesterase 22						cell cycle|embryo development|histone deubiquitination|histone H4 acetylation|histone ubiquitination|positive regulation of mitotic cell cycle|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	SAGA complex	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(1)	1																		---	---	---	---
PIGS	94005	broad.mit.edu	37	17	26888698	26888698	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:26888698delA	uc002hbo.2	-						PIGS_uc002hbn.2_Intron|PIGS_uc010wap.1_Intron	NM_033198	NP_149975			phosphatidylinositol glycan anchor biosynthesis,						attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			breast(2)|urinary_tract(1)|kidney(1)	4	Lung NSC(42;0.00431)																	---	---	---	---
SEZ6	124925	broad.mit.edu	37	17	27296914	27296914	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:27296914delC	uc002hdp.2	-	4	1109	c.915delG	c.(913-915)GGGfs	p.G305fs	SEZ6_uc002hdm.2_RNA|SEZ6_uc010cry.1_Frame_Shift_Del_p.G305fs|SEZ6_uc002hdq.1_Frame_Shift_Del_p.G180fs|SEZ6_uc010crz.1_Frame_Shift_Del_p.G305fs	NM_178860	NP_849191	Q53EL9	SEZ6_HUMAN	seizure related 6 homolog isoform 1	305	Extracellular (Potential).					integral to membrane|plasma membrane				large_intestine(1)|central_nervous_system(1)	2	Lung NSC(42;0.0137)		Epithelial(11;4.73e-06)|all cancers(11;2.91e-05)|BRCA - Breast invasive adenocarcinoma(11;8.06e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.111)															---	---	---	---
TAOK1	57551	broad.mit.edu	37	17	27794299	27794299	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:27794299delT	uc002hdz.1	+						TAOK1_uc010wbe.1_Intron|TAOK1_uc010wbf.1_Intron	NM_020791	NP_065842			TAO kinase 1						mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)|skin(1)	4			Colorectal(6;0.198)															---	---	---	---
SSH2	85464	broad.mit.edu	37	17	28104812	28104821	+	Intron	DEL	AAAAAAAAAA	-	-	rs144026943		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:28104812_28104821delAAAAAAAAAA	uc002heo.1	-						SSH2_uc010wbh.1_Intron|SSH2_uc002hep.1_Intron|SSH2_uc002her.2_Intron|SSH2_uc010csc.1_Intron	NM_033389	NP_203747			slingshot 2						actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(2)	2																		---	---	---	---
EFCAB5	374786	broad.mit.edu	37	17	28396072	28396072	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:28396072delA	uc002het.2	+						EFCAB5_uc010wbj.1_Intron|EFCAB5_uc010wbk.1_Intron|EFCAB5_uc010csd.2_Intron|EFCAB5_uc010cse.2_Intron|EFCAB5_uc010csf.2_Intron	NM_198529	NP_940931			EF-hand calcium binding domain 5 isoform a								calcium ion binding			ovary(1)|skin(1)	2																		---	---	---	---
CCDC55	84081	broad.mit.edu	37	17	28505077	28505077	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:28505077delT	uc002heu.2	+						CCDC55_uc002hev.2_Intron|CCDC55_uc010wbl.1_Intron|CCDC55_uc010wbm.1_Intron|CCDC55_uc002hex.2_Intron	NM_032141	NP_115517			coiled-coil domain containing 55 isoform 1						developmental process|nucleocytoplasmic transport|regulation of alternative nuclear mRNA splicing, via spliceosome	nuclear speck|ribonucleoprotein complex	mRNA binding|protein binding				0																		---	---	---	---
CPD	1362	broad.mit.edu	37	17	28783223	28783223	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:28783223delA	uc002hfb.1	+						CPD_uc010wbo.1_Intron|CPD_uc010wbp.1_Intron	NM_001304	NP_001295			carboxypeptidase D precursor						proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			liver(1)|skin(1)	2																		---	---	---	---
GOSR1	9527	broad.mit.edu	37	17	28849612	28849613	+	3'UTR	DEL	AA	-	-	rs76806222		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:28849612_28849613delAA	uc002hfe.2	+	9					GOSR1_uc002hfd.2_3'UTR|GOSR1_uc002hff.2_3'UTR	NM_004871	NP_004862			golgi SNAP receptor complex member 1 isoform 1						intra-Golgi vesicle-mediated transport|protein transport|retrograde transport, endosome to Golgi	Golgi membrane|integral to membrane|SNARE complex	SNAP receptor activity				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	17	29335110	29335110	+	IGR	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:29335110delG								RNF135 (8185 upstream) : NF1 (86885 downstream)														p.?(1)																					---	---	---	---
NF1	4763	broad.mit.edu	37	17	29553477	29553478	+	Frame_Shift_Ins	INS	-	C	C	rs145092683		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:29553477_29553478insC	uc002hgg.2	+	18	2359_2360	c.2026_2027insC	c.(2026-2028)ACCfs	p.T676fs	NF1_uc002hgh.2_Frame_Shift_Ins_p.T676fs|NF1_uc010csn.1_Frame_Shift_Ins_p.T536fs|NF1_uc002hgi.1_5'UTR	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	676					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)|p.P678fs*10(1)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)				D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			---	---	---	---
UTP6	55813	broad.mit.edu	37	17	30216089	30216089	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:30216089delA	uc002hgr.2	-						UTP6_uc002hgq.2_5'Flank|UTP6_uc010cst.2_Intron|UTP6_uc010wbw.1_Intron	NM_018428	NP_060898			hepatocellular carcinoma-associated antigen 66						rRNA processing	nucleolus	binding			ovary(1)	1		all_hematologic(16;0.0149)|Ovarian(249;0.021)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|Breast(31;0.231)																---	---	---	---
GGNBP2	79893	broad.mit.edu	37	17	34923771	34923771	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:34923771delT	uc002hnb.2	+						GGNBP2_uc002hna.2_Intron	NM_024835	NP_079111			zinc finger protein 403						cell differentiation|multicellular organismal development|spermatogenesis	cytoplasmic membrane-bounded vesicle				ovary(2)	2		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)														---	---	---	---
GGNBP2	79893	broad.mit.edu	37	17	34942126	34942126	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:34942126delA	uc002hnb.2	+						GGNBP2_uc002hna.2_3'UTR|GGNBP2_uc002hnc.1_Intron	NM_024835	NP_079111			zinc finger protein 403						cell differentiation|multicellular organismal development|spermatogenesis	cytoplasmic membrane-bounded vesicle				ovary(2)	2		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)														---	---	---	---
MRM1	79922	broad.mit.edu	37	17	34964978	34964979	+	3'UTR	DEL	GG	-	-	rs74361156	byFrequency;by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:34964978_34964979delGG	uc002hne.2	+	5					MRM1_uc002hnf.2_3'UTR	NM_024864	NP_079140			mitochondrial rRNA methyltransferase 1 homolog						RNA processing	mitochondrion	RNA binding|RNA methyltransferase activity				0		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)												OREG0024339	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
AATF	26574	broad.mit.edu	37	17	35346372	35346372	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:35346372delT	uc002hni.2	+						AATF_uc002hnj.2_Intron	NM_012138	NP_036270			apoptosis antagonizing transcription factor						anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of superoxide anion generation|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to DNA damage stimulus	centrosome|focal adhesion|nucleolus	leucine zipper domain binding|sequence-specific DNA binding transcription factor activity				0		Breast(25;0.00607)																---	---	---	---
ACACA	31	broad.mit.edu	37	17	35548923	35548923	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:35548923delT	uc002hnm.2	-						ACACA_uc002hnk.2_Intron|ACACA_uc002hnl.2_Intron|ACACA_uc002hnn.2_Intron|ACACA_uc002hno.2_Intron|ACACA_uc010cuy.2_Intron	NM_198836	NP_942133			acetyl-Coenzyme A carboxylase alpha isoform 2						acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)													---	---	---	---
ACACA	31	broad.mit.edu	37	17	35656166	35656167	+	Intron	INS	-	AT	AT			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:35656166_35656167insAT	uc002hnm.2	-						ACACA_uc002hnk.2_Intron|ACACA_uc002hnl.2_Intron|ACACA_uc002hnn.2_Intron|ACACA_uc002hno.2_Intron|ACACA_uc010cuz.2_Intron|ACACA_uc002hnq.2_Intron|ACACA_uc002hnp.1_Intron	NM_198836	NP_942133			acetyl-Coenzyme A carboxylase alpha isoform 2						acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)													---	---	---	---
TBC1D3	729873	broad.mit.edu	37	17	36375188	36375188	+	5'Flank	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:36375188delA	uc010wdn.1	-						uc002hpx.2_Intron					Homo sapiens TBC1D3 mRNA for TBC1 domain family, member 3, complete cds.							intracellular	Rab GTPase activator activity				0	Breast(7;2.97e-12)	Breast(25;0.102)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)														---	---	---	---
SOCS7	30837	broad.mit.edu	37	17	36520536	36520537	+	Intron	INS	-	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:36520536_36520537insC	uc002hqa.2	+						SOCS7_uc010cvl.2_Intron|SOCS7_uc002hqb.2_Intron	NM_014598	NP_055413			suppressor of cytokine signaling 7						intracellular signal transduction|negative regulation of signal transduction|regulation of growth	cytoplasm|nucleus|plasma membrane	protein binding|SH3 domain binding			skin(1)	1	Breast(7;3.47e-17)																	---	---	---	---
SRCIN1	80725	broad.mit.edu	37	17	36707452	36707452	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:36707452delG	uc002hqd.2	-	15	3126	c.2901delC	c.(2899-2901)CCCfs	p.P967fs	SRCIN1_uc002hqf.1_Frame_Shift_Del_p.P839fs|SRCIN1_uc002hqe.2_Frame_Shift_Del_p.P821fs	NM_025248	NP_079524	Q9C0H9	SRCN1_HUMAN	SNAP25-interacting protein	839	Pro-rich.				exocytosis|negative regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|regulation of cell migration|regulation of dendritic spine morphogenesis|substrate adhesion-dependent cell spreading	actin cytoskeleton|axon|cell junction|cytoplasm|dendrite|postsynaptic density|postsynaptic membrane	protein kinase binding				0																		---	---	---	---
C17orf98	388381	broad.mit.edu	37	17	36993202	36993205	+	Intron	DEL	AAAA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:36993202_36993205delAAAA	uc002hqv.2	-							NM_001080465	NP_001073934			hypothetical protein LOC388381												0																		---	---	---	---
MED24	9862	broad.mit.edu	37	17	38183951	38183951	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:38183951delG	uc002htt.2	-						MED24_uc010wes.1_Intron|MED24_uc010wet.1_Intron|MED24_uc002hts.2_Intron|MED24_uc002htu.2_Intron|MED24_uc010cwn.2_Intron|MED24_uc010weu.1_Intron|MED24_uc010wev.1_Intron|MED24_uc010wew.1_Intron|MED24_uc010wex.1_Intron	NM_014815	NP_055630			mediator complex subunit 24 isoform 1						androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)	1	Colorectal(19;0.000442)															OREG0024386	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
TOP2A	7153	broad.mit.edu	37	17	38573157	38573157	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:38573157delA	uc002huq.2	-							NM_001067	NP_001058			DNA topoisomerase II, alpha isozyme						apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)													---	---	---	---
CCR7	1236	broad.mit.edu	37	17	38712161	38712161	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:38712161delT	uc002huw.2	-							NM_001838	NP_001829			chemokine (C-C motif) receptor 7 precursor						cell maturation|immunological synapse formation|inflammatory response|interleukin-12 secretion|lymphocyte migration into lymph node|positive regulation of dendritic cell antigen processing and presentation|positive regulation of glycoprotein biosynthetic process|positive regulation of humoral immune response|positive regulation of hypersensitivity|positive regulation of interleukin-12 production|positive regulation of neutrophil chemotaxis|regulation of interferon-gamma production|regulation of interleukin-1 beta secretion|T cell costimulation	integral to membrane|intracellular	C-C chemokine receptor activity|chemokine (C-C motif) ligand 19 binding|chemokine (C-C motif) ligand 21 binding			breast(1)	1		Breast(137;0.000496)																---	---	---	---
Unknown	0	broad.mit.edu	37	17	39369595	39369603	+	IGR	DEL	TTTTTTTTT	-	-	rs5820393		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:39369595_39369603delTTTTTTTTT								KRTAP4-1 (6469 upstream) : KRTAP9-2 (13297 downstream)																																			---	---	---	---
ACLY	47	broad.mit.edu	37	17	40024247	40024247	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40024247delA	uc002hyg.2	-						KLHL11_uc002hyf.1_5'Flank|ACLY_uc002hyh.2_Intron|ACLY_uc002hyi.2_Intron|ACLY_uc010wfx.1_Intron|ACLY_uc010wfy.1_Intron	NM_001096	NP_001087			ATP citrate lyase isoform 1						ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			ovary(2)|central_nervous_system(1)	3		Breast(137;0.000143)																---	---	---	---
MLX	6945	broad.mit.edu	37	17	40720380	40720380	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40720380delA	uc002iag.2	+						MLX_uc002iaf.2_Intron|MLX_uc002iah.2_Intron	NM_170607	NP_733752			transcription factor-like protein 4 isoform						energy reserve metabolic process|negative regulation of transcription, DNA-dependent|positive regulation of cellular metabolic process	cytoplasm|nucleus	DNA binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding				0		all_cancers(22;4.26e-05)|Breast(137;0.000153)|all_epithelial(22;0.00148)		BRCA - Breast invasive adenocarcinoma(366;0.129)														---	---	---	---
CNTNAP1	8506	broad.mit.edu	37	17	40836955	40836955	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40836955delA	uc002iay.2	+						CNTNAP1_uc010wgs.1_Intron	NM_003632	NP_003623			contactin associated protein 1 precursor						axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(3)|breast(3)|upper_aerodigestive_tract(1)|lung(1)	8		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)														---	---	---	---
Unknown	0	broad.mit.edu	37	17	40905438	40905438	+	IGR	DEL	A	-	-	rs150921188	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40905438delA								EZH1 (8367 upstream) : LOC100190938 (86 downstream)																																			---	---	---	---
PSME3	10197	broad.mit.edu	37	17	40990332	40990333	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40990332_40990333insT	uc002ibr.2	+						PSME3_uc002ibp.2_Intron|PSME3_uc002ibq.2_Intron|PSME3_uc002ibs.2_Intron|PSME3_uc010whd.1_Intron	NM_005789	NP_005780			proteasome activator subunit 3 isoform 1						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of proteasomal protein catabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome activator complex	endopeptidase activator activity|identical protein binding|MDM2 binding|p53 binding				0		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)														---	---	---	---
AARSD1	80755	broad.mit.edu	37	17	41108984	41108988	+	Intron	DEL	TTTTT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:41108984_41108988delTTTTT	uc002icc.2	-						AARSD1_uc002icd.2_Intron|AARSD1_uc002ice.2_Intron|AARSD1_uc002icf.2_Intron|AARSD1_uc010whg.1_Intron|AARSD1_uc010cyu.1_Intron	NM_025267	NP_079543			alanyl-tRNA synthetase domain containing 1						alanyl-tRNA aminoacylation	cytoplasm	alanine-tRNA ligase activity|ATP binding|metal ion binding|nucleic acid binding				0		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.161)														---	---	---	---
BRCA1	672	broad.mit.edu	37	17	41231836	41231836	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:41231836delA	uc002icq.2	-						BRCA1_uc010whp.1_Intron|BRCA1_uc010whl.1_Intron|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Intron|BRCA1_uc002icu.2_Intron|BRCA1_uc010cyx.2_Intron|BRCA1_uc002ict.2_Intron|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Intron|BRCA1_uc002idc.1_Intron|BRCA1_uc010whr.1_Intron	NM_007294	NP_009225			breast cancer 1, early onset isoform 1						androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)				D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			---	---	---	---
BRCA1	672	broad.mit.edu	37	17	41321890	41321890	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:41321890delT	uc010whp.1	-						uc010czc.2_Intron|NBR1_uc010czd.2_5'Flank|NBR1_uc010diz.2_5'Flank|NBR1_uc010whu.1_5'Flank|NBR1_uc010whv.1_5'Flank|NBR1_uc010whw.1_5'Flank	NM_007298	NP_009229			breast cancer 1, early onset isoform 4						androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)				D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			---	---	---	---
ARL4D	379	broad.mit.edu	37	17	41477713	41477713	+	3'UTR	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:41477713delC	uc002idt.2	+	2						NM_001661	NP_001652			ADP-ribosylation factor-like 4D						protein secretion|small GTPase mediated signal transduction	cytoplasm|nucleolus|plasma membrane	GTP binding|GTPase activity|protein binding			ovary(1)	1		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.155)														---	---	---	---
GPATCH8	23131	broad.mit.edu	37	17	42512617	42512617	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:42512617delA	uc002igw.1	-						GPATCH8_uc002igv.1_Intron|GPATCH8_uc010wiz.1_Intron	NM_001002909	NP_001002909			G patch domain containing 8							intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)														---	---	---	---
Unknown	0	broad.mit.edu	37	17	43616612	43616612	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:43616612delA	uc002ijh.2	-						uc010wjv.1_Intron					Homo sapiens cDNA FLJ45049 fis, clone BRAWH3022347.																														---	---	---	---
MAPT	4137	broad.mit.edu	37	17	44101592	44101592	+	3'UTR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:44101592delA	uc002ijr.3	+	14					MAPT_uc010dau.2_3'UTR|MAPT_uc002ijs.3_3'UTR|MAPT_uc002ijx.3_3'UTR|MAPT_uc002ijt.3_3'UTR|MAPT_uc002iju.3_3'UTR|MAPT_uc002ijv.3_3'UTR	NM_016835	NP_058519			microtubule-associated protein tau isoform 1						cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			pancreas(1)	1		Melanoma(429;0.216)																---	---	---	---
Unknown	0	broad.mit.edu	37	17	44324687	44324687	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:44324687delT								KIAA1267 (21970 upstream) : ARL17B (39176 downstream)																																			---	---	---	---
GOSR2	9570	broad.mit.edu	37	17	45017754	45017754	+	3'UTR	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:45017754delG	uc002ila.2	+	6					GOSR2_uc010wkh.1_Intron|GOSR2_uc002ikz.2_Intron	NM_004287	NP_004278			golgi SNAP receptor complex member 2 isoform A						cellular membrane fusion|ER to Golgi vesicle-mediated transport|protein transport	Golgi membrane|integral to membrane	transporter activity			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(9;0.102)															---	---	---	---
NPEPPS	9520	broad.mit.edu	37	17	45662846	45662847	+	Intron	INS	-	T	T	rs147836270	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:45662846_45662847insT	uc002ilr.3	+						NPEPPS_uc010wkt.1_Intron|NPEPPS_uc010wku.1_Intron|NPEPPS_uc010dba.1_Intron|NPEPPS_uc010wkv.1_5'Flank	NM_006310	NP_006301			aminopeptidase puromycin sensitive						proteolysis	cytosol|nucleus	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding				0																		---	---	---	---
NPEPPS	9520	broad.mit.edu	37	17	45679204	45679205	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:45679204_45679205delAA	uc002ilr.3	+						NPEPPS_uc010wkt.1_Intron|NPEPPS_uc010wku.1_Intron|NPEPPS_uc010wkv.1_Intron|NPEPPS_uc002ils.1_5'Flank	NM_006310	NP_006301			aminopeptidase puromycin sensitive						proteolysis	cytosol|nucleus	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding				0																		---	---	---	---
KPNB1	3837	broad.mit.edu	37	17	45734124	45734125	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:45734124_45734125insA	uc002ilt.1	+						KPNB1_uc010wkw.1_Intron|KPNB1_uc010wkx.1_5'Flank	NM_002265	NP_002256			karyopherin beta 1						DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|protein import into nucleus, translocation|ribosomal protein import into nucleus|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein domain specific binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3																		---	---	---	---
MRPL10	124995	broad.mit.edu	37	17	45904363	45904363	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:45904363delG	uc002ilz.2	-						MRPL10_uc010wky.1_Intron|MRPL10_uc002ily.2_Intron	NM_145255	NP_660298			mitochondrial ribosomal protein L10 precursor						ribosome biogenesis|translation	mitochondrial large ribosomal subunit	structural constituent of ribosome			ovary(1)	1																		---	---	---	---
SLC35B1	10237	broad.mit.edu	37	17	47780109	47780109	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:47780109delA	uc002iph.1	-						SLC35B1_uc002ipi.1_Intron|SLC35B1_uc002ipj.1_Intron	NM_005827	NP_005818			solute carrier family 35, member B1							endoplasmic reticulum membrane|integral to membrane|microsome	UDP-galactose transmembrane transporter activity				0																		---	---	---	---
NME1-NME2	654364	broad.mit.edu	37	17	49245465	49245466	+	Intron	DEL	TA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:49245465_49245466delTA	uc002itk.2	+						NME1-NME2_uc002itj.2_Intron|NME2_uc002itl.2_Intron|NME2_uc002itm.2_Intron|NME2_uc002itn.2_Intron|NME2_uc002ito.2_Intron	NM_002512	NP_002503			nucleoside diphosphate kinase B						cell adhesion|CTP biosynthetic process|GTP biosynthetic process|negative regulation of apoptosis|nucleobase, nucleoside and nucleotide interconversion|positive regulation of epithelial cell proliferation|positive regulation of keratinocyte differentiation|UTP biosynthetic process	cytosol|lamellipodium|nucleus|ruffle	ATP binding|DNA binding|metal ion binding|nucleoside diphosphate kinase activity|protein binding|protein histidine kinase activity|sequence-specific DNA binding transcription factor activity				0			BRCA - Breast invasive adenocarcinoma(22;1.54e-08)															---	---	---	---
Unknown	0	broad.mit.edu	37	17	51834303	51834303	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:51834303delT								None (None upstream) : KIF2B (65936 downstream)																																			---	---	---	---
HLF	3131	broad.mit.edu	37	17	53345288	53345288	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:53345288delC	uc002iug.1	+	2	817	c.292delC	c.(292-294)CCCfs	p.P98fs	HLF_uc010dce.1_Frame_Shift_Del_p.P13fs|HLF_uc002iuh.2_Frame_Shift_Del_p.P13fs|HLF_uc010wni.1_Frame_Shift_Del_p.F46fs	NM_002126	NP_002117	Q16534	HLF_HUMAN	hepatic leukemia factor	98					multicellular organismal development|rhythmic process|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2								T	TCF3	ALL								---	---	---	---
ANKFN1	162282	broad.mit.edu	37	17	54305178	54305178	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:54305178delT	uc002iun.1	+						uc002iuo.2_5'Flank	NM_153228	NP_694960			ankyrin-repeat and fibronectin type III domain											large_intestine(1)|ovary(1)	2																		---	---	---	---
MSI2	124540	broad.mit.edu	37	17	55334578	55334581	+	Intron	DEL	CCCC	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:55334578_55334581delCCCC	uc002iuz.1	+						MSI2_uc010wnm.1_Intron|MSI2_uc002iva.2_Intron	NM_138962	NP_620412			musashi 2 isoform a							cytoplasm	nucleotide binding|RNA binding			central_nervous_system(1)|pancreas(1)	2	Breast(9;1.78e-08)			GBM - Glioblastoma multiforme(1;0.0025)				T	HOXA9	CML								---	---	---	---
MSI2	124540	broad.mit.edu	37	17	55339499	55339499	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:55339499delT	uc002iuz.1	+						MSI2_uc010wnm.1_Intron|MSI2_uc002iva.2_Intron|MSI2_uc002ivb.2_RNA	NM_138962	NP_620412			musashi 2 isoform a							cytoplasm	nucleotide binding|RNA binding			central_nervous_system(1)|pancreas(1)	2	Breast(9;1.78e-08)			GBM - Glioblastoma multiforme(1;0.0025)				T	HOXA9	CML								---	---	---	---
LPO	4025	broad.mit.edu	37	17	56343830	56343830	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:56343830delT	uc002ivt.2	+						LPO_uc010wns.1_Intron|LPO_uc010dcp.2_Intron|LPO_uc010dcq.2_Intron|LPO_uc010dcr.2_Intron	NM_006151	NP_006142			lactoperoxidase isoform 1 preproprotein						hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|breast(1)	2																		---	---	---	---
RNF43	54894	broad.mit.edu	37	17	56435161	56435161	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:56435161delC	uc002iwf.2	-	8	3932	c.1976delG	c.(1975-1977)GGTfs	p.G659fs	RNF43_uc010wnv.1_Frame_Shift_Del_p.G618fs|RNF43_uc002iwh.3_Frame_Shift_Del_p.G659fs|RNF43_uc002iwg.3_Frame_Shift_Del_p.G659fs|RNF43_uc010dcw.2_Frame_Shift_Del_p.G532fs	NM_017763	NP_060233	Q68DV7	RNF43_HUMAN	ring finger protein 43 precursor	659	Pro-rich.|Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			ovary(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)																	---	---	---	---
HSF5	124535	broad.mit.edu	37	17	56554105	56554106	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:56554105_56554106insA	uc002iwi.1	-							NM_001080439	NP_001073908			heat shock transcription factor family member 5							nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)																	---	---	---	---
HSF5	124535	broad.mit.edu	37	17	56554230	56554230	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:56554230delT	uc002iwi.1	-							NM_001080439	NP_001073908			heat shock transcription factor family member 5							nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)																	---	---	---	---
TEX14	56155	broad.mit.edu	37	17	56691030	56691030	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:56691030delT	uc010dcz.1	-						TEX14_uc002iwr.1_Intron|TEX14_uc002iws.1_Intron|TEX14_uc010dda.1_Intron	NM_198393	NP_938207			testis expressed sequence 14 isoform a							cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)																	---	---	---	---
TRIM37	4591	broad.mit.edu	37	17	57093165	57093165	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:57093165delA	uc002iwy.3	-						TRIM37_uc002iwz.3_Intron|TRIM37_uc002ixa.3_Intron|TRIM37_uc010woc.1_Intron	NM_001005207	NP_001005207			tripartite motif-containing 37 protein							perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			lung(2)|pancreas(2)|ovary(1)|skin(1)|breast(1)	7	Medulloblastoma(34;0.0922)|all_neural(34;0.101)													Mulibrey_Nanism				---	---	---	---
TRIM37	4591	broad.mit.edu	37	17	57138340	57138340	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:57138340delG	uc002iwy.3	-						TRIM37_uc002iwz.3_Intron|TRIM37_uc002ixa.3_Intron|TRIM37_uc010woc.1_Intron	NM_001005207	NP_001005207			tripartite motif-containing 37 protein							perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			lung(2)|pancreas(2)|ovary(1)|skin(1)|breast(1)	7	Medulloblastoma(34;0.0922)|all_neural(34;0.101)													Mulibrey_Nanism				---	---	---	---
TRIM37	4591	broad.mit.edu	37	17	57148100	57148100	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:57148100delA	uc002iwy.3	-						TRIM37_uc002iwz.3_Intron|TRIM37_uc002ixa.3_Intron|TRIM37_uc010woc.1_Intron	NM_001005207	NP_001005207			tripartite motif-containing 37 protein							perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			lung(2)|pancreas(2)|ovary(1)|skin(1)|breast(1)	7	Medulloblastoma(34;0.0922)|all_neural(34;0.101)													Mulibrey_Nanism				---	---	---	---
TRIM37	4591	broad.mit.edu	37	17	57165879	57165881	+	Intron	DEL	TTT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:57165879_57165881delTTT	uc002iwy.3	-						TRIM37_uc002iwz.3_Intron|TRIM37_uc002ixa.3_Intron|TRIM37_uc010woc.1_Intron	NM_001005207	NP_001005207			tripartite motif-containing 37 protein							perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			lung(2)|pancreas(2)|ovary(1)|skin(1)|breast(1)	7	Medulloblastoma(34;0.0922)|all_neural(34;0.101)													Mulibrey_Nanism				---	---	---	---
GDPD1	284161	broad.mit.edu	37	17	57311748	57311751	+	Intron	DEL	CAAA	-	-	rs113162600		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:57311748_57311751delCAAA	uc002ixk.1	+						GDPD1_uc002ixj.2_Intron	NM_182569	NP_872375			glycerophosphodiester phosphodiesterase domain						glycerol metabolic process|lipid metabolic process	cytoplasm|integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding				0	all_neural(34;0.0837)|Medulloblastoma(34;0.0922)																	---	---	---	---
HEATR6	63897	broad.mit.edu	37	17	58153604	58153604	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:58153604delA	uc002iyk.1	-						HEATR6_uc010wos.1_5'Flank	NM_022070	NP_071353			HEAT repeat containing 6								binding			ovary(1)|skin(1)	2	all_cancers(5;2.25e-13)|Breast(5;4.84e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		BRCA - Breast invasive adenocarcinoma(1;5.93e-19)|Epithelial(12;7.59e-12)|all cancers(12;1.26e-10)															---	---	---	---
USP32	84669	broad.mit.edu	37	17	58303679	58303679	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:58303679delT	uc002iyo.1	-						USP32_uc002iyn.1_Intron	NM_032582	NP_115971			ubiquitin specific protease 32						protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)															---	---	---	---
BCAS3	54828	broad.mit.edu	37	17	58952111	58952111	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:58952111delT	uc002iyv.3	+						BCAS3_uc010wow.1_Intron|BCAS3_uc002iyu.3_Intron|BCAS3_uc002iyw.3_Intron	NM_001099432	NP_001092902			breast carcinoma amplified sequence 3 isoform 1							nucleus				ovary(2)|central_nervous_system(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)															---	---	---	---
MED13	9969	broad.mit.edu	37	17	60028493	60028493	+	Intron	DEL	A	-	-	rs77073490		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:60028493delA	uc002izo.2	-							NM_005121	NP_005112			mediator complex subunit 13						androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	17	60318950	60318950	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:60318950delT								MED13 (176307 upstream) : TBC1D3P2 (23119 downstream)																																			---	---	---	---
EFCAB3	146779	broad.mit.edu	37	17	60483827	60483827	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:60483827delT	uc002izu.1	+						EFCAB3_uc010wpc.1_Intron	NM_173503	NP_775774			EF-hand calcium binding domain 3 isoform b								calcium ion binding			skin(1)	1			BRCA - Breast invasive adenocarcinoma(2;2.27e-11)															---	---	---	---
CCDC45	90799	broad.mit.edu	37	17	62512808	62512808	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:62512808delT	uc002jem.2	+						CCDC45_uc002jen.2_Intron|CCDC45_uc010wqb.1_Intron	NM_138363	NP_612372			coiled-coil domain containing 45							centrosome|spindle pole	protein binding				0	Breast(5;1.32e-14)		BRCA - Breast invasive adenocarcinoma(8;8.6e-12)															---	---	---	---
LRRC37A3	374819	broad.mit.edu	37	17	62856785	62856785	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:62856785delT	uc002jey.2	-	11	4010	c.3479delA	c.(3478-3480)AACfs	p.N1160fs	LRRC37A3_uc010wqg.1_Frame_Shift_Del_p.N278fs|LRRC37A3_uc002jex.1_Frame_Shift_Del_p.N137fs|LRRC37A3_uc010wqf.1_Frame_Shift_Del_p.N198fs|LRRC37A3_uc010dek.1_Frame_Shift_Del_p.N166fs	NM_199340	NP_955372	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	1160	Extracellular (Potential).|LRR 11.					integral to membrane					0																		---	---	---	---
LRRC37A3	374819	broad.mit.edu	37	17	62864851	62864851	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:62864851delT	uc002jey.2	-						LRRC37A3_uc010wqg.1_Intron|LRRC37A3_uc010wqf.1_Intron|LRRC37A3_uc010dek.1_Intron	NM_199340	NP_955372			leucine rich repeat containing 37, member A3							integral to membrane					0																		---	---	---	---
RGS9	8787	broad.mit.edu	37	17	63186049	63186049	+	Intron	DEL	T	-	-	rs112552969		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:63186049delT	uc002jfe.2	+						RGS9_uc010dem.2_Intron|RGS9_uc002jfd.2_Intron|RGS9_uc002jff.2_Intron|RGS9_uc002jfg.2_Intron	NM_003835	NP_003826			regulator of G-protein signaling 9 isoform 1						intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			ovary(2)|skin(2)	4																		---	---	---	---
CCDC46	201134	broad.mit.edu	37	17	64171073	64171074	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:64171073_64171074insA	uc002jfl.2	-						CCDC46_uc002jfm.2_Intron|CCDC46_uc010dep.2_Intron	NM_145036	NP_659473			coiled-coil domain containing 46 isoform a							centrosome					0			BRCA - Breast invasive adenocarcinoma(6;1.53e-06)															---	---	---	---
APOH	350	broad.mit.edu	37	17	64216930	64216930	+	Intron	DEL	A	-	-	rs78195703		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:64216930delA	uc002jfn.3	-							NM_000042	NP_000033			apolipoprotein H precursor						blood coagulation, intrinsic pathway|negative regulation of angiogenesis|negative regulation of blood coagulation|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of myeloid cell apoptosis|negative regulation of smooth muscle cell apoptosis|plasminogen activation|positive regulation of lipoprotein lipase activity|triglyceride metabolic process|triglyceride transport	cell surface|chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	eukaryotic cell surface binding|glycoprotein binding|heparin binding|lipoprotein lipase activator activity|phospholipid binding				0			BRCA - Breast invasive adenocarcinoma(6;9.74e-08)															---	---	---	---
NOL11	25926	broad.mit.edu	37	17	65732696	65732696	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:65732696delT	uc002jgd.1	+						NOL11_uc010wql.1_Intron|NOL11_uc010deu.1_Intron	NM_015462	NP_056277			nucleolar protein 11							nucleolus					0	all_cancers(12;1.54e-10)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0518)|COAD - Colon adenocarcinoma(4;0.0977)|LUSC - Lung squamous cell carcinoma(166;0.24)															---	---	---	---
BPTF	2186	broad.mit.edu	37	17	65906916	65906916	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:65906916delA	uc002jgf.2	+						BPTF_uc002jge.2_Intron	NM_182641	NP_872579			bromodomain PHD finger transcription factor						brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)															---	---	---	---
KPNA2	3838	broad.mit.edu	37	17	66033402	66033402	+	Intron	DEL	A	-	-	rs34040105		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:66033402delA	uc002jgk.2	+						KPNA2_uc002jgl.2_Intron	NM_002266	NP_002257			karyopherin alpha 2						DNA metabolic process|G2 phase of mitotic cell cycle|interspecies interaction between organisms|M phase specific microtubule process|NLS-bearing substrate import into nucleus|regulation of DNA recombination	cytoplasm|nuclear pore|nucleoplasm	histone deacetylase binding|nuclear localization sequence binding|protein transporter activity			central_nervous_system(2)	2	all_cancers(12;1.18e-09)		BRCA - Breast invasive adenocarcinoma(8;1.03e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)															---	---	---	---
LOC651250	651250	broad.mit.edu	37	17	66124428	66124428	+	RNA	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:66124428delA	uc002jgq.2	+	6		c.3551delA			LOC651250_uc002kit.2_RNA|LOC651250_uc002jgo.1_Intron	NR_027418				Homo sapiens cDNA FLJ33831 fis, clone CTONG2003937.												0																		---	---	---	---
ABCA8	10351	broad.mit.edu	37	17	66921168	66921168	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:66921168delA	uc002jhp.2	-						ABCA8_uc002jhq.2_Intron|ABCA8_uc010wqq.1_Intron|ABCA8_uc010wqr.1_Intron|ABCA8_uc002jhr.2_Intron	NM_007168	NP_009099			ATP-binding cassette, sub-family A member 8							integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)																	---	---	---	---
ABCA6	23460	broad.mit.edu	37	17	67124603	67124604	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:67124603_67124604delTT	uc002jhw.1	-							NM_080284	NP_525023			ATP-binding cassette, sub-family A, member 6						transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)																	---	---	---	---
ABCA10	10349	broad.mit.edu	37	17	67189694	67189694	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:67189694delT	uc010dfa.1	-	15	2460	c.1581delA	c.(1579-1581)AAAfs	p.K527fs	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfb.1_Frame_Shift_Del_p.K128fs	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	527	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)																	---	---	---	---
ABCA10	10349	broad.mit.edu	37	17	67197935	67197935	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:67197935delT	uc010dfa.1	-						ABCA10_uc010wqt.1_Intron|ABCA10_uc010dfb.1_Intron|ABCA10_uc010dfc.1_Intron	NM_080282	NP_525021			ATP-binding cassette, sub-family A, member 10						transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)																	---	---	---	---
KCNJ16	3773	broad.mit.edu	37	17	68128128	68128128	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:68128128delT	uc002jin.2	+						KCNJ16_uc002jio.2_Intron|KCNJ16_uc002jip.2_Intron|KCNJ16_uc002jiq.2_Intron	NM_018658	NP_061128			potassium inwardly-rectifying channel J16						synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Breast(10;2.96e-09)																	---	---	---	---
Unknown	0	broad.mit.edu	37	17	73231941	73231941	+	IGR	DEL	T	-	-	rs71898043		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73231941delT								NUP85 (87 upstream) : GGA3 (754 downstream)																																			---	---	---	---
RECQL5	9400	broad.mit.edu	37	17	73625328	73625328	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73625328delC	uc010dgl.2	-	16	2331	c.2175delG	c.(2173-2175)GGGfs	p.G725fs	RECQL5_uc010dgk.2_Frame_Shift_Del_p.G698fs|RECQL5_uc002jot.3_5'Flank	NM_004259	NP_004250	O94762	RECQ5_HUMAN	RecQ protein-like 5 isoform 1	725					DNA recombination|DNA repair	cytoplasm|nuclear membrane|nucleolus|nucleoplasm	ATP binding|ATP-dependent helicase activity|DNA helicase activity|nucleic acid binding			kidney(3)	3	all_cancers(13;2.73e-08)|Breast(9;6.04e-09)|all_epithelial(9;6.79e-09)		all cancers(21;1.15e-06)|Epithelial(20;2.19e-06)|Lung(188;0.101)|LUSC - Lung squamous cell carcinoma(166;0.112)										Other_identified_genes_with_known_or_suspected_DNA_repair_function					---	---	---	---
TRIM47	91107	broad.mit.edu	37	17	73874707	73874707	+	5'Flank	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73874707delC	uc002jpw.2	-						TRIM47_uc002jpv.2_5'Flank	NM_033452	NP_258411			tripartite motif-containing 47							cytoplasm|nucleus	zinc ion binding			ovary(2)|prostate(1)|lung(1)|breast(1)	5			Epithelial(20;4.23e-06)|all cancers(21;5.24e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00092)|LUSC - Lung squamous cell carcinoma(166;0.154)															---	---	---	---
ACOX1	51	broad.mit.edu	37	17	73947678	73947678	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73947678delA	uc002jqf.2	-						ACOX1_uc010wsq.1_Intron|ACOX1_uc002jqe.2_Intron|ACOX1_uc010wsr.1_Intron	NM_007292	NP_009223			acyl-Coenzyme A oxidase 1 isoform b						fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|prostaglandin metabolic process|very long-chain fatty acid metabolic process	peroxisomal matrix	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity|flavin adenine dinucleotide binding|protein N-terminus binding			ovary(1)	1																		---	---	---	---
EXOC7	23265	broad.mit.edu	37	17	74077588	74077588	+	3'UTR	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:74077588delC	uc002jqs.2	-	20					ZACN_uc002jqn.2_Intron|ZACN_uc002jqo.2_Intron|ZACN_uc010dgu.2_Intron|EXOC7_uc002jqp.1_3'UTR|EXOC7_uc010dgv.1_3'UTR|EXOC7_uc002jqq.2_3'UTR|EXOC7_uc010wsw.1_3'UTR|EXOC7_uc010wsx.1_3'UTR|EXOC7_uc002jqr.2_3'UTR|EXOC7_uc010wsv.1_3'UTR	NM_001145297	NP_001138769			exocyst complex component 7 isoform 4						exocytosis|protein transport	centriolar satellite|cytosol|exocyst|plasma membrane	protein binding				0			LUSC - Lung squamous cell carcinoma(166;0.187)															---	---	---	---
RNF157	114804	broad.mit.edu	37	17	74160693	74160693	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:74160693delA	uc002jqz.2	-						RNF157_uc002jra.2_Intron	NM_052916	NP_443148			ring finger protein 157								zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(166;0.187)															---	---	---	---
RNF157	114804	broad.mit.edu	37	17	74161765	74161765	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:74161765delT	uc002jqz.2	-						RNF157_uc002jra.2_Intron	NM_052916	NP_443148			ring finger protein 157								zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(166;0.187)															---	---	---	---
QRICH2	84074	broad.mit.edu	37	17	74283094	74283095	+	Intron	INS	-	C	C	rs11657066		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:74283094_74283095insC	uc002jrd.1	-						QRICH2_uc010wsz.1_Intron|QRICH2_uc010dgw.1_Intron	NM_032134	NP_115510			glutamine rich 2								protein binding			ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)|skin(1)	5																		---	---	---	---
MFSD11	79157	broad.mit.edu	37	17	74738414	74738414	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:74738414delT	uc002jta.2	+						MFSD11_uc002jtb.2_Intron|MFSD11_uc010dha.2_Intron|MFSD11_uc002jtc.2_Intron|MFSD11_uc002jtd.3_Intron|MFSD11_uc010dhb.2_Intron|MFSD11_uc002jte.2_Intron	NM_024311	NP_077287			major facilitator superfamily domain containing							integral to membrane				ovary(1)	1																		---	---	---	---
PGS1	9489	broad.mit.edu	37	17	76397284	76397284	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:76397284delG	uc002jvm.2	+						PGS1_uc010wtt.1_Intron|PGS1_uc010dho.2_Intron|PGS1_uc002jvn.2_Intron|PGS1_uc002jvo.2_Intron|PGS1_uc002jvp.1_Intron	NM_024419	NP_077733			phosphatidylglycerophosphate synthase 1						phospholipid biosynthetic process	endoplasmic reticulum|mitochondrion	ATP binding|CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity				0			BRCA - Breast invasive adenocarcinoma(99;0.00144)|OV - Ovarian serous cystadenocarcinoma(97;0.031)															---	---	---	---
DNAH17	8632	broad.mit.edu	37	17	76554440	76554440	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:76554440delG	uc002jvv.1	-											RecName: Full=Dynein heavy chain 17, axonemal; AltName: Full=Axonemal beta dynein heavy chain 17; AltName: Full=Ciliary dynein heavy chain 17; AltName: Full=Ciliary dynein heavy chain-like protein 1; AltName: Full=Axonemal dynein heavy chain-like protein 1; AltName: Full=Dynein light chain 2, axonemal;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)															---	---	---	---
RPTOR	57521	broad.mit.edu	37	17	78674612	78674614	+	Intron	DEL	TGA	-	-	rs145354332		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:78674612_78674614delTGA	uc002jyt.1	+						RPTOR_uc002jys.2_Intron|RPTOR_uc010wuf.1_Intron|RPTOR_uc010wug.1_Intron	NM_020761	NP_065812			raptor isoform 1						cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			lung(4)|urinary_tract(1)|ovary(1)	6																		---	---	---	---
BAIAP2	10458	broad.mit.edu	37	17	79031774	79031780	+	Intron	DEL	CCCCCCC	-	-	rs72416300		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:79031774_79031780delCCCCCCC	uc002jzg.2	+						BAIAP2_uc002jyz.3_Intron|BAIAP2_uc002jza.2_Intron|BAIAP2_uc002jzc.2_Intron|BAIAP2_uc002jzb.2_Intron|BAIAP2_uc002jzd.2_Intron|BAIAP2_uc002jzf.2_Intron|BAIAP2_uc002jze.2_Intron|BAIAP2_uc010wuh.1_Intron	NM_017451	NP_059345			BAI1-associated protein 2 isoform 2						axonogenesis|filopodium assembly|insulin receptor signaling pathway|regulation of actin cytoskeleton organization|response to bacterium	cell junction|cytoskeleton|cytosol|filopodium|nucleus|ruffle	cytoskeletal adaptor activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding				0	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)															---	---	---	---
FSCN2	25794	broad.mit.edu	37	17	79497255	79497255	+	Intron	DEL	G	-	-	rs78333089	byFrequency;by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:79497255delG	uc010wup.1	+						FSCN2_uc010wuo.1_Intron	NM_012418	NP_036550			fascin 2 isoform 1						actin filament bundle assembly|anatomical structure morphogenesis|visual perception	actin cytoskeleton|cytoplasm|stereocilium	actin filament binding|protein binding, bridging				0	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)															---	---	---	---
WDR45L	56270	broad.mit.edu	37	17	80574691	80574691	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:80574691delA	uc002kfq.2	-						WDR45L_uc002kfr.2_Intron	NM_019613	NP_062559			WDR45-like						autophagy|response to starvation	organelle membrane	phosphatidylinositol-3,5-bisphosphate binding			ovary(1)	1	Breast(20;0.00106)|all_neural(118;0.0952)	all_cancers(8;0.101)|all_epithelial(8;0.198)	BRCA - Breast invasive adenocarcinoma(99;0.0262)|OV - Ovarian serous cystadenocarcinoma(97;0.0835)															---	---	---	---
TBCD	6904	broad.mit.edu	37	17	80726117	80726117	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:80726117delG	uc002kfz.2	+						TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron	NM_005993	NP_005984			beta-tubulin cofactor D						'de novo' posttranslational protein folding|adherens junction assembly|negative regulation of cell-substrate adhesion|negative regulation of microtubule polymerization|post-chaperonin tubulin folding pathway|tight junction assembly	adherens junction|cytoplasm|lateral plasma membrane|microtubule|tight junction	beta-tubulin binding|chaperone binding|GTPase activator activity				0	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0266)|all_epithelial(8;0.0696)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.18)															---	---	---	---
TBCD	6904	broad.mit.edu	37	17	80730173	80730173	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:80730173delT	uc002kfz.2	+						TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron	NM_005993	NP_005984			beta-tubulin cofactor D						'de novo' posttranslational protein folding|adherens junction assembly|negative regulation of cell-substrate adhesion|negative regulation of microtubule polymerization|post-chaperonin tubulin folding pathway|tight junction assembly	adherens junction|cytoplasm|lateral plasma membrane|microtubule|tight junction	beta-tubulin binding|chaperone binding|GTPase activator activity				0	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0266)|all_epithelial(8;0.0696)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.18)															---	---	---	---
TBCD	6904	broad.mit.edu	37	17	80879308	80879308	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:80879308delT	uc002kfz.2	+						TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kgb.1_Intron	NM_005993	NP_005984			beta-tubulin cofactor D						'de novo' posttranslational protein folding|adherens junction assembly|negative regulation of cell-substrate adhesion|negative regulation of microtubule polymerization|post-chaperonin tubulin folding pathway|tight junction assembly	adherens junction|cytoplasm|lateral plasma membrane|microtubule|tight junction	beta-tubulin binding|chaperone binding|GTPase activator activity				0	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0266)|all_epithelial(8;0.0696)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.18)															---	---	---	---
Unknown	0	broad.mit.edu	37	18	117217	117217	+	RNA	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:117217delC	uc002kke.2	+	3		c.643delC								Homo sapiens Rho-associated, coiled-coil containing protein kinase 1, mRNA (cDNA clone IMAGE:5269982), complete cds.																														---	---	---	---
THOC1	9984	broad.mit.edu	37	18	265348	265348	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:265348delT	uc002kkj.3	-	3	184	c.144delA	c.(142-144)AAAfs	p.K48fs	THOC1_uc002kkk.3_RNA|THOC1_uc002kkl.2_Frame_Shift_Del_p.K48fs	NM_005131	NP_005122	Q96FV9	THOC1_HUMAN	THO complex 1	48					apoptosis|intronless viral mRNA export from host nucleus|mRNA processing|regulation of transcription elongation, DNA-dependent|RNA splicing|signal transduction|transcription, DNA-dependent	cytoplasm|nuclear matrix|nuclear speck|THO complex part of transcription export complex	DNA binding|protein binding|RNA binding			ovary(1)	1		all_cancers(4;0.0896)|Myeloproliferative disorder(11;0.0412)																---	---	---	---
THOC1	9984	broad.mit.edu	37	18	265533	265533	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:265533delA	uc002kkj.3	-						THOC1_uc002kkk.3_Intron|THOC1_uc002kkl.2_Intron	NM_005131	NP_005122			THO complex 1						apoptosis|intronless viral mRNA export from host nucleus|mRNA processing|regulation of transcription elongation, DNA-dependent|RNA splicing|signal transduction|transcription, DNA-dependent	cytoplasm|nuclear matrix|nuclear speck|THO complex part of transcription export complex	DNA binding|protein binding|RNA binding			ovary(1)	1		all_cancers(4;0.0896)|Myeloproliferative disorder(11;0.0412)																---	---	---	---
LPIN2	9663	broad.mit.edu	37	18	2922287	2922287	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:2922287delT	uc002klo.2	-							NM_014646	NP_055461			lipin 2						fatty acid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|triglyceride biosynthetic process	cytosol|endoplasmic reticulum membrane|nucleus	phosphatidate phosphatase activity|transcription coactivator activity			ovary(1)|skin(1)	2				READ - Rectum adenocarcinoma(2;0.0419)|Colorectal(6;0.156)														---	---	---	---
LPIN2	9663	broad.mit.edu	37	18	2946646	2946647	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:2946646_2946647insA	uc002klo.2	-						LOC727896_uc010wyu.1_5'Flank	NM_014646	NP_055461			lipin 2						fatty acid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|triglyceride biosynthetic process	cytosol|endoplasmic reticulum membrane|nucleus	phosphatidate phosphatase activity|transcription coactivator activity			ovary(1)|skin(1)	2				READ - Rectum adenocarcinoma(2;0.0419)|Colorectal(6;0.156)														---	---	---	---
MYOM1	8736	broad.mit.edu	37	18	3134954	3134954	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:3134954delT	uc002klp.2	-						MYOM1_uc002klq.2_Intron	NM_003803	NP_003794			myomesin 1 isoform a							striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5																		---	---	---	---
MYOM1	8736	broad.mit.edu	37	18	3188633	3188633	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:3188633delA	uc002klp.2	-						MYOM1_uc002klq.2_Intron	NM_003803	NP_003794			myomesin 1 isoform a							striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5																		---	---	---	---
MYL12A	10627	broad.mit.edu	37	18	3255845	3255845	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:3255845delA	uc002klr.2	+	4	840	c.445delA	c.(445-447)AAAfs	p.K149fs	MYL12A_uc002kls.2_Frame_Shift_Del_p.K155fs	NM_006471	NP_006462	P19105	ML12A_HUMAN	myosin, light chain 12A, regulatory,	149	EF-hand 3.					myosin complex	calcium ion binding|protein binding				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	18	5003297	5003298	+	IGR	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:5003297_5003298insA								DLGAP1 (548031 upstream) : LOC642597 (140374 downstream)																																			---	---	---	---
L3MBTL4	91133	broad.mit.edu	37	18	6322510	6322510	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:6322510delA	uc002kmz.3	-						L3MBTL4_uc010dkt.2_Intron	NM_173464	NP_775735			l(3)mbt-like 4						chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|pancreas(1)	3		Colorectal(10;0.0249)																---	---	---	---
LAMA1	284217	broad.mit.edu	37	18	7034405	7034406	+	Intron	INS	-	AT	AT			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:7034405_7034406insAT	uc002knm.2	-						LAMA1_uc010wzj.1_Intron	NM_005559	NP_005550			laminin, alpha 1 precursor						axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
Unknown	0	broad.mit.edu	37	18	10184900	10184900	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:10184900delA								VAPA (224883 upstream) : APCDD1 (269725 downstream)																																			---	---	---	---
NAPG	8774	broad.mit.edu	37	18	10530751	10530752	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:10530751_10530752insT	uc002kon.2	+						NAPG_uc010wzr.1_Intron|NAPG_uc002koo.2_Intron	NM_003826	NP_003817			N-ethylmaleimide-sensitive factor attachment						cellular membrane fusion|intra-Golgi vesicle-mediated transport|intracellular protein transport|protein complex assembly|protein stabilization	membrane|membrane fraction|mitochondrion	protein binding				0																		---	---	---	---
FAM38B	63895	broad.mit.edu	37	18	10671476	10671476	+	3'UTR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:10671476delA	uc002kor.3	-	14					FAM38B_uc002koq.2_3'UTR	NM_022068	NP_071351			family with sequence similarity 38, member B							integral to membrane	ion channel activity			ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	18	11610675	11610675	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:11610675delA								FAM38B (908696 upstream) : GNAL (78461 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	18	11639513	11639513	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:11639513delA								FAM38B (937534 upstream) : GNAL (49623 downstream)																																			---	---	---	---
IMPA2	3613	broad.mit.edu	37	18	11998925	11998936	+	Intron	DEL	CCGCCCCCCCCC	-	-	rs60067478		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:11998925_11998936delCCGCCCCCCCCC	uc002kqp.1	+						IMPA2_uc002kqo.1_Intron|IMPA2_uc010dlb.1_Intron|IMPA2_uc002kqq.1_Intron	NM_014214	NP_055029			inositol(myo)-1(or 4)-monophosphatase 2						inositol phosphate dephosphorylation|signal transduction	cytoplasm	inositol-1(or 4)-monophosphatase activity|metal ion binding|protein homodimerization activity			skin(2)	2					Lithium(DB01356)													---	---	---	---
MC5R	4161	broad.mit.edu	37	18	13825564	13825568	+	5'Flank	DEL	AAAAA	-	-	rs33981843		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:13825564_13825568delAAAAA	uc010xaf.1	+							NM_005913	NP_005904			melanocortin 5 receptor						G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			ovary(3)|lung(2)|breast(1)	6																		---	---	---	---
NPC1	4864	broad.mit.edu	37	18	21123312	21123314	+	Intron	DEL	AAA	-	-	rs144573107		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:21123312_21123314delAAA	uc002kum.3	-						NPC1_uc010xaz.1_Intron|NPC1_uc010xba.1_Intron	NM_000271	NP_000262			Niemann-Pick disease, type C1 precursor						autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)																	---	---	---	---
LAMA3	3909	broad.mit.edu	37	18	21363786	21363786	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:21363786delT	uc002kuq.2	+						LAMA3_uc010dlv.1_Intron|LAMA3_uc002kur.2_Intron	NM_198129	NP_937762			laminin alpha 3 subunit isoform 1						cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
IMPACT	55364	broad.mit.edu	37	18	22023312	22023312	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:22023312delT	uc002kvh.3	+						IMPACT_uc002kvg.3_Intron	NM_018439	NP_060909			Impact homolog												0	all_cancers(21;0.00018)|all_epithelial(16;1.5e-06)|Lung NSC(20;0.0027)|all_lung(20;0.0085)|Colorectal(14;0.0361)|Ovarian(20;0.0991)																	---	---	---	---
SS18	6760	broad.mit.edu	37	18	23612294	23612294	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:23612294delA	uc002kvm.2	-						SS18_uc002kvn.2_Intron|SS18_uc010xbf.1_Intron|SS18_uc010xbg.1_Intron|SS18_uc010xbh.1_Intron|SS18_uc010xbi.1_Intron	NM_001007559	NP_001007560			synovial sarcoma translocation, chromosome 18						positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding		SS18/SSX1(1169)|SS18/SSX2(702)|SS18/SSX4(12)	soft_tissue(1883)|ovary(1)	1884	all_cancers(21;0.000194)|Lung NSC(5;0.000413)|all_lung(6;0.00118)|Ovarian(20;0.124)							T	SSX1| SSX2	synovial sarcoma								---	---	---	---
SS18	6760	broad.mit.edu	37	18	23667409	23667409	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:23667409delA	uc002kvm.2	-						SS18_uc002kvn.2_Intron|SS18_uc010xbf.1_Intron|SS18_uc010xbg.1_Intron|SS18_uc010xbh.1_Intron|SS18_uc010xbi.1_Intron|SS18_uc010dlz.1_Intron	NM_001007559	NP_001007560			synovial sarcoma translocation, chromosome 18						positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding		SS18/SSX1(1169)|SS18/SSX2(702)|SS18/SSX4(12)	soft_tissue(1883)|ovary(1)	1884	all_cancers(21;0.000194)|Lung NSC(5;0.000413)|all_lung(6;0.00118)|Ovarian(20;0.124)							T	SSX1| SSX2	synovial sarcoma								---	---	---	---
KCTD1	284252	broad.mit.edu	37	18	24056414	24056414	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:24056414delT	uc002kvw.2	-						KCTD1_uc010xbj.1_Intron|KCTD1_uc010xbk.1_Intron|KCTD1_uc002kvy.2_Intron	NM_001136205	NP_001129677			potassium channel tetramerisation domain						negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|voltage-gated potassium channel complex	transcription corepressor activity|transcription factor binding|voltage-gated potassium channel activity			ovary(1)	1	all_cancers(21;0.00191)|Lung NSC(5;0.000698)|all_lung(6;0.0019)|Ovarian(20;0.0848)		Epithelial(2;7.8e-06)|OV - Ovarian serous cystadenocarcinoma(3;9.02e-06)|all cancers(3;3.37e-05)															---	---	---	---
DSC3	1825	broad.mit.edu	37	18	28588133	28588133	+	Intron	DEL	A	-	-	rs34151598		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:28588133delA	uc002kwj.3	-						DSC3_uc002kwi.3_Intron	NM_001941	NP_001932			desmocollin 3 isoform Dsc3a preproprotein						homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			ovary(2)|skin(2)	4			OV - Ovarian serous cystadenocarcinoma(10;0.125)															---	---	---	---
DSC1	1823	broad.mit.edu	37	18	28728328	28728328	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:28728328delA	uc002kwn.2	-						DSC1_uc002kwm.2_Intron	NM_024421	NP_077739			desmocollin 1 isoform Dsc1a preproprotein						homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(10;0.00778)															---	---	---	---
DSG1	1828	broad.mit.edu	37	18	28923779	28923779	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:28923779delT	uc002kwp.2	+						DSG1_uc010xbp.1_5'UTR	NM_001942	NP_001933			desmoglein 1 preproprotein						calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			skin(3)|ovary(2)|central_nervous_system(2)	7			OV - Ovarian serous cystadenocarcinoma(10;0.00559)															---	---	---	---
B4GALT6	9331	broad.mit.edu	37	18	29206810	29206811	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:29206810_29206811insA	uc002kwz.3	-						B4GALT6_uc010dma.2_Intron|B4GALT6_uc010dmb.2_Intron|B4GALT6_uc002kwy.3_5'Flank	NM_004775	NP_004766			beta-1,4-galactosyltransferase 6						post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	metal ion binding				0			OV - Ovarian serous cystadenocarcinoma(10;0.00791)															---	---	---	---
KIAA1012	22878	broad.mit.edu	37	18	29429382	29429382	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:29429382delA	uc002kxc.3	-						KIAA1012_uc002kxb.3_Intron|KIAA1012_uc002kxd.3_Intron	NM_014939	NP_055754			hypothetical protein LOC22878						ER to Golgi vesicle-mediated transport	cis-Golgi network					0																		---	---	---	---
KIAA1012	22878	broad.mit.edu	37	18	29489050	29489050	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:29489050delA	uc002kxc.3	-						KIAA1012_uc002kxb.3_Intron|KIAA1012_uc002kxd.3_Intron|KIAA1012_uc002kxe.2_Intron	NM_014939	NP_055754			hypothetical protein LOC22878						ER to Golgi vesicle-mediated transport	cis-Golgi network					0																		---	---	---	---
RNF125	54941	broad.mit.edu	37	18	29646061	29646061	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:29646061delA	uc002kxf.1	+							NM_017831	NP_060301			ring finger protein 125						negative regulation of type I interferon production	intracellular	ligase activity|zinc ion binding				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	18	29656288	29656288	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:29656288delT								RNF125 (3134 upstream) : RNF138 (15549 downstream)																																			---	---	---	---
C18orf34	374864	broad.mit.edu	37	18	30825168	30825168	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:30825168delT	uc002kxn.2	-						C18orf34_uc010dme.1_Intron|C18orf34_uc010xbr.1_Intron|C18orf34_uc010dmf.1_Intron|C18orf34_uc002kxo.2_Intron|C18orf34_uc002kxp.2_Intron	NM_001105528	NP_001098998			hypothetical protein LOC374864 isoform 1											ovary(1)	1																		---	---	---	---
ASXL3	80816	broad.mit.edu	37	18	31241861	31241862	+	Intron	INS	-	A	A	rs146967011	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:31241861_31241862insA	uc010dmg.1	+						ASXL3_uc002kxq.2_Intron	NM_030632	NP_085135			additional sex combs like 3						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3																		---	---	---	---
KIAA1632	57724	broad.mit.edu	37	18	43437677	43437679	+	Intron	DEL	TTC	-	-	rs143918507		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:43437677_43437679delTTC	uc002lbm.2	-							NM_020964	NP_066015			hypothetical protein LOC57724						autophagy						0																		---	---	---	---
ATP5A1	498	broad.mit.edu	37	18	43670052	43670052	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:43670052delG	uc002lbr.1	-						ATP5A1_uc010dnl.1_Intron|ATP5A1_uc002lbs.1_Intron|ATP5A1_uc002lbt.1_Intron|ATP5A1_uc010xct.1_Intron|ATP5A1_uc010dnm.1_Intron	NM_004046	NP_004037			ATP synthase, H+ transporting, mitochondrial F1						ATP hydrolysis coupled proton transport|embryo development|lipid metabolic process|negative regulation of endothelial cell proliferation|respiratory electron transport chain	mitochondrial matrix|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism				0																		---	---	---	---
PIAS2	9063	broad.mit.edu	37	18	44400843	44400843	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:44400843delA	uc002lck.2	-						PIAS2_uc010dnp.2_Intron|PIAS2_uc002lcl.2_Intron|PIAS2_uc010xda.1_Intron	NM_004671	NP_004662			protein inhibitor of activated STAT X isoform						androgen receptor signaling pathway|negative regulation of androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|PML body	androgen receptor binding|DNA binding|protein binding|SUMO ligase activity|transcription coactivator activity|zinc ion binding			ovary(2)|breast(1)|skin(1)	4																		---	---	---	---
Unknown	0	broad.mit.edu	37	18	46005697	46005697	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:46005697delT								ZBTB7C (70034 upstream) : KIAA0427 (59730 downstream)																																			---	---	---	---
ME2	4200	broad.mit.edu	37	18	48434589	48434589	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:48434589delT	uc002ley.2	+						ME2_uc010dpd.2_Intron	NM_002396	NP_002387			malic enzyme 2, NAD(+)-dependent, mitochondrial						malate metabolic process	mitochondrial matrix	electron carrier activity|malate dehydrogenase (decarboxylating) activity|malate dehydrogenase (oxaloacetate-decarboxylating) activity|metal ion binding|NAD binding				0		Colorectal(6;0.0273)|all_epithelial(6;0.118)		Colorectal(21;0.0313)|READ - Rectum adenocarcinoma(32;0.105)|STAD - Stomach adenocarcinoma(97;0.184)	NADH(DB00157)													---	---	---	---
DCC	1630	broad.mit.edu	37	18	50589440	50589441	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:50589440_50589441insT	uc002lfe.1	+						DCC_uc010xdr.1_Intron|DCC_uc010dpf.1_Intron	NM_005215	NP_005206			netrin receptor DCC precursor						apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)														---	---	---	---
TXNL1	9352	broad.mit.edu	37	18	54283634	54283634	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:54283634delA	uc002lgg.2	-						TXNL1_uc010xdz.1_Intron|TXNL1_uc002lgh.2_Intron|TXNL1_uc002lgi.2_Intron|TXNL1_uc002lgj.1_Intron	NM_004786	NP_004777			thioredoxin-like 1						cell redox homeostasis|electron transport chain|glycerol ether metabolic process|transport	cytoplasm	electron carrier activity|protein disulfide oxidoreductase activity				0				READ - Rectum adenocarcinoma(59;0.193)|Colorectal(16;0.211)														---	---	---	---
ATP8B1	5205	broad.mit.edu	37	18	55373823	55373824	+	Intron	INS	-	A	A	rs34583775		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:55373823_55373824insA	uc002lgw.2	-						uc002lgv.1_Intron	NM_005603	NP_005594			ATPase, class I, type 8B, member 1						ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(5)|ovary(2)|central_nervous_system(2)|lung(1)	10		Colorectal(73;0.229)												Byler_disease				---	---	---	---
NEDD4L	23327	broad.mit.edu	37	18	55989643	55989643	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:55989643delT	uc002lgy.2	+						NEDD4L_uc002lgz.2_Intron|NEDD4L_uc002lgx.2_Intron|NEDD4L_uc010xee.1_Intron|NEDD4L_uc002lhc.2_Intron|NEDD4L_uc002lhd.2_Intron|NEDD4L_uc002lhb.2_Intron|NEDD4L_uc002lhe.2_Intron|NEDD4L_uc002lhf.2_Intron|NEDD4L_uc002lhg.2_Intron|NEDD4L_uc002lhh.2_Intron|NEDD4L_uc010dpm.1_5'Flank	NM_001144967	NP_001138439			neural precursor cell expressed, developmentally						cellular sodium ion homeostasis|excretion|interspecies interaction between organisms|positive regulation of endocytosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein catabolic process|response to metal ion|sodium ion transport|water homeostasis	cytoplasm	protein binding|sodium channel regulator activity|ubiquitin-protein ligase activity			lung(4)	4																OREG0025007	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
SERPINB8	5271	broad.mit.edu	37	18	61652328	61652328	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:61652328delA	uc002ljv.2	+	6	738	c.569delA	c.(568-570)GAAfs	p.E190fs	SERPINB8_uc002ljt.2_Frame_Shift_Del_p.E190fs|SERPINB8_uc002lju.2_Frame_Shift_Del_p.E190fs|SERPINB8_uc010xex.1_Frame_Shift_Del_p.E8fs	NM_198833	NP_942130	P50452	SPB8_HUMAN	serine (or cysteine) proteinase inhibitor, clade	190					regulation of proteolysis	cytosol	protein binding|serine-type endopeptidase inhibitor activity			skin(1)	1		Esophageal squamous(42;0.129)																---	---	---	---
CCDC102B	79839	broad.mit.edu	37	18	66503865	66503867	+	Intron	DEL	AAT	-	-	rs71369199	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:66503865_66503867delAAT	uc002lkk.2	+						CCDC102B_uc002lki.2_Intron|CCDC102B_uc002lkj.1_Intron	NM_001093729	NP_001087198			coiled-coil domain containing 102B											ovary(1)|lung(1)|skin(1)	3		Esophageal squamous(42;0.0559)|Colorectal(73;0.0604)																---	---	---	---
TSHZ1	10194	broad.mit.edu	37	18	72998443	72998443	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:72998443delC	uc002lly.2	+	2	1509	c.946delC	c.(946-948)CCCfs	p.P316fs		NM_005786	NP_005777	Q6ZSZ6	TSH1_HUMAN	teashirt family zinc finger 1	361						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)														---	---	---	---
ZNF236	7776	broad.mit.edu	37	18	74617099	74617099	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:74617099delT	uc002lmi.2	+						ZNF236_uc002lmj.2_Intron	NM_007345	NP_031371			zinc finger protein 236						cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)														---	---	---	---
PARD6G	84552	broad.mit.edu	37	18	77917845	77917845	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:77917845delG	uc002lny.2	-	3	1106	c.940delC	c.(940-942)CAGfs	p.Q314fs	LOC100130522_uc002lnx.2_Intron|LOC100130522_uc010xfn.1_Intron|LOC100130522_uc010xfo.1_Intron	NM_032510	NP_115899	Q9BYG4	PAR6G_HUMAN	PAR-6 gamma protein	314					cell cycle|cell division|tight junction assembly	cytosol|tight junction	protein binding				0		all_cancers(4;5.63e-22)|all_epithelial(4;5.86e-15)|all_lung(4;1.32e-05)|Ovarian(4;1.33e-05)|Lung NSC(4;2.77e-05)|Esophageal squamous(42;0.0157)|all_hematologic(56;0.13)|Melanoma(33;0.144)		Epithelial(2;1.48e-13)|all cancers(1;5.77e-13)|OV - Ovarian serous cystadenocarcinoma(15;2.74e-10)|BRCA - Breast invasive adenocarcinoma(31;0.00166)|STAD - Stomach adenocarcinoma(84;0.18)|Lung(128;0.23)														---	---	---	---
PARD6G	84552	broad.mit.edu	37	18	77918406	77918406	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:77918406delG	uc002lny.2	-	3	545	c.379delC	c.(379-381)CGGfs	p.R127fs	LOC100130522_uc002lnx.2_Intron|LOC100130522_uc010xfn.1_Intron|LOC100130522_uc010xfo.1_Intron	NM_032510	NP_115899	Q9BYG4	PAR6G_HUMAN	PAR-6 gamma protein	127	Interaction with PARD3 and CDC42 (By similarity).				cell cycle|cell division|tight junction assembly	cytosol|tight junction	protein binding				0		all_cancers(4;5.63e-22)|all_epithelial(4;5.86e-15)|all_lung(4;1.32e-05)|Ovarian(4;1.33e-05)|Lung NSC(4;2.77e-05)|Esophageal squamous(42;0.0157)|all_hematologic(56;0.13)|Melanoma(33;0.144)		Epithelial(2;1.48e-13)|all cancers(1;5.77e-13)|OV - Ovarian serous cystadenocarcinoma(15;2.74e-10)|BRCA - Breast invasive adenocarcinoma(31;0.00166)|STAD - Stomach adenocarcinoma(84;0.18)|Lung(128;0.23)														---	---	---	---
BSG	682	broad.mit.edu	37	19	579340	579341	+	Intron	INS	-	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:579340_579341insC	uc002loz.2	+						BSG_uc002loy.2_Intron|BSG_uc002lpa.2_Intron|BSG_uc002lpb.2_Intron|BSG_uc010drr.2_Intron|BSG_uc002lpc.2_Frame_Shift_Ins_p.S133fs	NM_001728	NP_001719			basigin isoform 1 precursor						blood coagulation|cell surface receptor linked signaling pathway|leukocyte migration|pyruvate metabolic process	Golgi membrane|integral to membrane|melanosome	lactate transmembrane transporter activity|mannose binding|protein binding				0		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
GRIN3B	116444	broad.mit.edu	37	19	1004499	1004499	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:1004499delC	uc002lqo.1	+							NM_138690	NP_619635			glutamate receptor, ionotropic,						ionotropic glutamate receptor signaling pathway|protein insertion into membrane|regulation of calcium ion transport	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|ionotropic glutamate receptor activity|neurotransmitter receptor activity				0		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000226)|all_lung(49;0.000353)|Breast(49;0.00066)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Glycine(DB00145)|L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)													---	---	---	---
C19orf26	255057	broad.mit.edu	37	19	1231206	1231206	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:1231206delC	uc002lrm.2	-	9	1305	c.1030delG	c.(1030-1032)GATfs	p.D344fs		NM_152769	NP_689982	Q8N350	DOS_HUMAN	downstream of Stk11	370						integral to membrane					0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)											HNSCC(14;0.022)			---	---	---	---
GAMT	2593	broad.mit.edu	37	19	1399063	1399063	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:1399063delG	uc002lsj.2	-						uc002lsi.1_5'Flank|GAMT_uc002lsk.2_Intron	NM_000156	NP_000147			guanidinoacetate N-methyltransferase isoform a						creatine biosynthetic process|muscle contraction	cytosol	guanidinoacetate N-methyltransferase activity				0		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Lung NSC(49;0.000195)|Breast(49;0.000231)|all_lung(49;0.000247)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Creatine(DB00148)													---	---	---	---
DAZAP1	26528	broad.mit.edu	37	19	1430254	1430254	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:1430254delC	uc002lsn.2	+	10	953	c.764delC	c.(763-765)GCCfs	p.A255fs	DAZAP1_uc002lsm.2_Frame_Shift_Del_p.A255fs|DAZAP1_uc002lso.2_Frame_Shift_Del_p.A254fs|DAZAP1_uc002lsl.1_Frame_Shift_Del_p.A255fs	NM_018959	NP_061832	Q96EP5	DAZP1_HUMAN	DAZ associated protein 1 isoform b	255	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleotide binding|RNA binding			breast(1)	1		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
SPPL2B	56928	broad.mit.edu	37	19	2341094	2341102	+	Intron	DEL	CTCCCTGGA	-	-	rs76166147		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:2341094_2341102delCTCCCTGGA	uc002lvs.2	+						SPPL2B_uc010dsw.1_In_Frame_Del_p.PPW318del|SPPL2B_uc010dsy.1_In_Frame_Del_p.PPW318del|SPPL2B_uc010dsz.1_In_Frame_Del_p.PPW346del|SPPL2B_uc002lvr.2_Intron|SPPL2B_uc010dta.1_In_Frame_Del_p.PPW198del|SPPL2B_uc002lvu.2_In_Frame_Del_p.PPW140del	NM_152988	NP_694533			signal peptide peptidase-like 2B isoform 2							Golgi membrane|integral to membrane	aspartic-type endopeptidase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
SGTA	6449	broad.mit.edu	37	19	2762757	2762757	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:2762757delC	uc002lwi.1	-							NM_003021	NP_003012			small glutamine-rich tetratricopeptide						interspecies interaction between organisms	cytoplasm	protein binding			ovary(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
AES	166	broad.mit.edu	37	19	3057884	3057884	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:3057884delT	uc002lwy.1	-						AES_uc002lwx.1_5'Flank|AES_uc002lwz.1_Intron|AES_uc002lxa.1_Intron|AES_uc002lxb.1_Intron|AES_uc002lxc.2_Intron	NM_001130	NP_001121			amino-terminal enhancer of split isoform b						negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of response to cytokine stimulus|negative regulation of transcription from RNA polymerase II promoter|organ morphogenesis|response to interleukin-1|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
MATK	4145	broad.mit.edu	37	19	3779654	3779654	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:3779654delC	uc002lyt.2	-						MATK_uc002lyv.2_Intron|MATK_uc002lyu.2_Intron|MATK_uc010dtq.2_Intron	NM_139355	NP_647612			megakaryocyte-associated tyrosine kinase isoform						cell proliferation|mesoderm development|positive regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			stomach(2)|ovary(1)|lung(1)|large_intestine(1)	5		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
ZFR2	23217	broad.mit.edu	37	19	3870955	3870955	+	5'Flank	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:3870955delT	uc002lyw.2	-						ZFR2_uc010xhx.1_5'Flank|ZFR2_uc002lyx.3_5'Flank|ZFR2_uc010xhy.1_5'Flank	NM_015174	NP_055989			zinc finger RNA binding protein 2 isoform 1							intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)														---	---	---	---
EEF2	1938	broad.mit.edu	37	19	3977616	3977616	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:3977616delA	uc002lze.2	-							NM_001961	NP_001952			eukaryotic translation elongation factor 2							cytosol|ribonucleoprotein complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|GBM - Glioblastoma multiforme(1328;0.0223)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
FSD1	79187	broad.mit.edu	37	19	4306470	4306470	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4306470delT	uc002lzy.2	+						FSD1_uc010xie.1_Intron|FSD1_uc010xif.1_Intron|FSD1_uc002lzz.2_Intron	NM_024333	NP_077309			fibronectin type III and SPRY domain containing						cell division|mitosis	cleavage furrow|microtubule|microtubule organizing center|nucleus				skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.034)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
SH3GL1	6455	broad.mit.edu	37	19	4362255	4362257	+	Intron	DEL	GGA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4362255_4362257delGGA	uc002maj.2	-						SH3GL1_uc002mak.2_Intron|SH3GL1_uc010xig.1_Intron	NM_003025	NP_003016			SH3-domain GRB2-like 1						central nervous system development|endocytosis|signal transduction	early endosome membrane	lipid binding|protein binding			ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0152)|STAD - Stomach adenocarcinoma(1328;0.182)				T	MLL	AL								---	---	---	---
PLIN4	729359	broad.mit.edu	37	19	4510386	4510389	+	Intron	DEL	AAAC	-	-	rs56906779		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4510386_4510389delAAAC	uc002mar.1	-						PLIN4_uc010dub.1_Intron	NM_001080400	NP_001073869			plasma membrane associated protein, S3-12							lipid particle|plasma membrane					0																		---	---	---	---
SEMA6B	10501	broad.mit.edu	37	19	4554379	4554380	+	Intron	INS	-	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4554379_4554380insC	uc010duc.1	-						SEMA6B_uc010dud.2_Intron|SEMA6B_uc010xih.1_Intron	NM_032108	NP_115484			semaphorin 6B precursor						cell differentiation|nervous system development	integral to membrane	receptor activity			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
KDM4B	23030	broad.mit.edu	37	19	5047350	5047350	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:5047350delG	uc002mbq.3	+						KDM4B_uc010xil.1_Intron|KDM4B_uc010xim.1_Intron	NM_015015	NP_055830			jumonji domain containing 2B						chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			lung(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	19	5402157	5402158	+	IGR	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:5402157_5402158insT								PTPRS (61343 upstream) : ZNRF4 (53268 downstream)																																			---	---	---	---
SAFB	6294	broad.mit.edu	37	19	5667115	5667115	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:5667115delG	uc002mcf.2	+	18	2446	c.2393delG	c.(2392-2394)TGGfs	p.W798fs	SAFB_uc002mcg.2_Frame_Shift_Del_p.W798fs|SAFB_uc002mce.3_Frame_Shift_Del_p.W797fs|SAFB_uc010xir.1_Frame_Shift_Del_p.W797fs|SAFB_uc010xis.1_Frame_Shift_Del_p.W729fs|SAFB_uc010xit.1_Frame_Shift_Del_p.W640fs|SAFB_uc010xiu.1_Frame_Shift_Del_p.W597fs	NM_002967	NP_002958	Q15424	SAFB1_HUMAN	scaffold attachment factor B	798	Interaction with SAFB2.|Arg-rich.|Gly-rich.				chromatin organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding			ovary(1)|liver(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;0.000222)														---	---	---	---
TMEM146	257062	broad.mit.edu	37	19	5754227	5754227	+	Frame_Shift_Del	DEL	C	-	-	rs116784915	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:5754227delC	uc002mda.2	+	13	1310	c.1249delC	c.(1249-1251)CCCfs	p.P417fs	TMEM146_uc010duj.1_Frame_Shift_Del_p.P75fs	NM_152784	NP_689997	Q86XM0	TM146_HUMAN	transmembrane protein 146 precursor	417	Extracellular (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3																		---	---	---	---
Unknown	0	broad.mit.edu	37	19	6562609	6562609	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6562609delT								TNFSF9 (26670 upstream) : CD70 (20526 downstream)																																			---	---	---	---
C3	718	broad.mit.edu	37	19	6713913	6713913	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6713913delC	uc002mfm.2	-							NM_000064	NP_000055			complement component 3 precursor						complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)														---	---	---	---
GPR108	56927	broad.mit.edu	37	19	6735981	6735981	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6735981delA	uc002mfp.2	-						GPR108_uc002mfn.2_Intron|GPR108_uc002mfo.3_Intron|GPR108_uc010duw.2_Intron	NM_001080452	NP_001073921			G protein-coupled receptor 108 isoform 1							integral to membrane					0																OREG0025202	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
STXBP2	6813	broad.mit.edu	37	19	7706774	7706774	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:7706774delC	uc002mha.3	+						STXBP2_uc002mhb.3_Intron|STXBP2_uc010dvj.2_Intron|STXBP2_uc010xjr.1_Intron|STXBP2_uc010dvk.2_Intron|STXBP2_uc002mhc.3_Intron|STXBP2_uc002mhe.1_5'Flank	NM_006949	NP_008880			syntaxin binding protein 2 isoform a						leukocyte mediated cytotoxicity|neutrophil degranulation|protein transport|regulation of mast cell degranulation|vesicle docking involved in exocytosis	azurophil granule|cytolytic granule|cytosol|specific granule|tertiary granule	syntaxin-3 binding			central_nervous_system(1)	1																		---	---	---	---
CLEC4G	339390	broad.mit.edu	37	19	7795847	7795847	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:7795847delC	uc002mhp.3	-							NM_198492	NP_940894			C-type lectin domain family 4, member G							integral to membrane	protein binding|sugar binding				0																		---	---	---	---
TIMM44	10469	broad.mit.edu	37	19	8006187	8006190	+	Intron	DEL	TTTT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:8006187_8006190delTTTT	uc002miz.2	-						TIMM44_uc002mja.2_Intron|TIMM44_uc010dvx.1_Intron	NM_006351	NP_006342			translocase of inner mitochondrial membrane 44						protein targeting to mitochondrion	mitochondrial inner membrane presequence translocase complex|mitochondrial matrix	ATP binding|P-P-bond-hydrolysis-driven protein transmembrane transporter activity			ovary(1)	1																		---	---	---	---
HNRNPM	4670	broad.mit.edu	37	19	8520264	8520264	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:8520264delT	uc010dwe.2	+						HNRNPM_uc010dwc.1_Intron|HNRNPM_uc010xke.1_Intron|HNRNPM_uc010dwd.2_Intron	NM_005968	NP_005959			heterogeneous nuclear ribonucleoprotein M						alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|integral to plasma membrane|nuclear matrix|nucleolus|paraspeckles	nucleotide binding|protein domain specific binding|RNA binding				0																		---	---	---	---
MUC16	94025	broad.mit.edu	37	19	8987392	8987392	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:8987392delG	uc002mkp.2	-						MUC16_uc010dwi.2_Intron|MUC16_uc010dwj.2_Intron|MUC16_uc010xki.1_Intron	NM_024690	NP_078966			mucin 16						cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57																		---	---	---	---
Unknown	0	broad.mit.edu	37	19	9212881	9212882	+	IGR	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9212881_9212882insA								OR1M1 (8020 upstream) : OR7G2 (65 downstream)																																			---	---	---	---
OR7G2	390882	broad.mit.edu	37	19	9213598	9213599	+	Frame_Shift_Ins	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9213598_9213599insA	uc010xkk.1	-	1	384_385	c.384_385insT	c.(382-387)TTTGCTfs	p.F128fs		NM_001005193	NP_001005193	Q8NG99	OR7G2_HUMAN	olfactory receptor, family 7, subfamily G,	107_108	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1																		---	---	---	---
ZNF559	84527	broad.mit.edu	37	19	9451758	9451758	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9451758delT	uc002mlg.2	+						ZNF559_uc002mlf.2_Intron|ZNF559_uc010dwl.1_Intron|ZNF559_uc010xkn.1_Intron|ZNF559_uc010dwm.1_Intron|ZNF559_uc002mle.3_Intron|ZNF559_uc010dwk.1_Intron|ZNF559_uc002mld.2_Intron|ZNF559_uc010dwo.1_Intron|ZNF559_uc002mlh.1_Intron|ZNF177_uc002mli.2_Intron|ZNF177_uc002mlj.2_Intron	NM_032497	NP_115886			zinc finger protein 559						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	19	9802059	9802060	+	Intron	INS	-	T	T	rs144137282	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9802059_9802060insT	uc010xkx.1	-											RecName: Full=Zinc finger protein 562;																														---	---	---	---
DNMT1	1786	broad.mit.edu	37	19	10288073	10288073	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10288073delA	uc002mng.2	-						DNMT1_uc010xlc.1_Intron|DNMT1_uc002mnh.2_Intron|DNMT1_uc010xld.1_Intron|DNMT1_uc010dxb.1_Intron	NM_001379	NP_001370			DNA (cytosine-5-)-methyltransferase 1 isoform b						chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			ovary(2)|prostate(1)|lung(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)													---	---	---	---
ICAM3	3385	broad.mit.edu	37	19	10446091	10446092	+	Intron	INS	-	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10446091_10446092insC	uc002mob.2	-						RAVER1_uc002moa.2_5'Flank|ICAM3_uc010dxd.1_Intron|ICAM3_uc010xlf.1_3'UTR	NM_002162	NP_002153			intercellular adhesion molecule 3 precursor						cell-cell adhesion|regulation of immune response	integral to plasma membrane	integrin binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(20;6.13e-09)|Epithelial(33;9.69e-06)|all cancers(31;2.05e-05)															---	---	---	---
SMARCA4	6597	broad.mit.edu	37	19	11144368	11144368	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:11144368delT	uc002mqf.3	+						SMARCA4_uc010dxp.2_Intron|SMARCA4_uc010dxo.2_Intron|SMARCA4_uc010dxq.2_Intron|SMARCA4_uc010dxr.2_Intron|SMARCA4_uc002mqj.3_Intron|SMARCA4_uc010dxs.2_Intron|SMARCA4_uc010dxt.1_Intron|SMARCA4_uc002mqh.3_Intron|SMARCA4_uc002mqi.1_Intron	NM_003072	NP_003063			SWI/SNF-related matrix-associated						chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity			lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)						F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				---	---	---	---
KANK2	25959	broad.mit.edu	37	19	11304979	11304980	+	Intron	DEL	CT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:11304979_11304980delCT	uc010dxv.2	-						KANK2_uc002mqm.2_Intron|KANK2_uc002mqo.3_Intron|KANK2_uc002mqp.1_5'Flank|KANK2_uc002mqq.2_Intron	NM_015493	NP_056308			ankyrin repeat domain 25 isoform 1												0																		---	---	---	---
LPPR2	64748	broad.mit.edu	37	19	11465693	11465693	+	5'Flank	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:11465693delG	uc002mre.1	+						LPPR2_uc002mrf.1_5'Flank	NM_022737	NP_073574			lipid phosphate phosphatase-related protein type							integral to membrane	phosphatidate phosphatase activity			large_intestine(1)	1																		---	---	---	---
LPPR2	64748	broad.mit.edu	37	19	11472996	11472996	+	Intron	DEL	C	-	-	rs3833252		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:11472996delC	uc002mre.1	+						LPPR2_uc002mrf.1_Intron|LPPR2_uc010dxy.1_5'UTR	NM_022737	NP_073574			lipid phosphate phosphatase-related protein type							integral to membrane	phosphatidate phosphatase activity			large_intestine(1)	1																		---	---	---	---
EPOR	2057	broad.mit.edu	37	19	11488473	11488473	+	3'UTR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:11488473delA	uc002mrh.2	-	2										SubName: Full=Erythropoietin receptor; Flags: Fragment;							extracellular region|integral to plasma membrane	erythropoietin receptor activity|identical protein binding			ovary(1)	1					Darbepoetin alfa(DB00012)|Epoetin alfa(DB00016)											OREG0025254	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
RGL3	57139	broad.mit.edu	37	19	11517667	11517667	+	Intron	DEL	T	-	-	rs5827125		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:11517667delT	uc002mrp.2	-						RGL3_uc002mrn.2_Intron|RGL3_uc002mrm.2_Intron|RGL3_uc002mro.2_Intron	NM_001035223	NP_001030300			ral guanine nucleotide dissociation						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular				ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	19	11696740	11696740	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:11696740delT								ACP5 (6939 upstream) : ZNF627 (11495 downstream)																																			---	---	---	---
WDR83	84292	broad.mit.edu	37	19	12779285	12779285	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:12779285delC	uc002mue.3	+						MAN2B1_uc002mub.2_5'Flank|MAN2B1_uc010dyv.1_5'Flank|WDR83_uc002muc.2_Intron|C19orf56_uc002mud.2_Intron|WDR83_uc010dyw.2_5'Flank	NM_001099737	NP_001093207			mitogen-activated protein kinase organizer 1						nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|cytoplasm				lung(1)|breast(1)	2																		---	---	---	---
DHPS	1725	broad.mit.edu	37	19	12790112	12790112	+	Intron	DEL	A	-	-	rs78778363		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:12790112delA	uc002muh.1	-						DHPS_uc002muf.1_Intron|DHPS_uc002mug.1_Intron|DHPS_uc002mui.1_Intron|DHPS_uc002muj.1_Intron|DHPS_uc002muk.1_Intron|DHPS_uc010xmn.1_Intron	NM_001930	NP_001921			deoxyhypusine synthase isoform a						peptidyl-lysine modification to hypusine|positive regulation of cell proliferation|post-translational protein modification|spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase|translation	cytosol	deoxyhypusine synthase activity|protein binding			central_nervous_system(1)	1					Sulfadoxine(DB01299)													---	---	---	---
NFIX	4784	broad.mit.edu	37	19	13105127	13105128	+	5'Flank	DEL	GT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:13105127_13105128delGT	uc002mwd.2	+							NM_002501	NP_002492			nuclear factor I/X (CCAAT-binding transcription						DNA replication|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			breast(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(19;8.2e-22)															---	---	---	---
CACNA1A	773	broad.mit.edu	37	19	13373629	13373629	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:13373629delT	uc010dze.2	-	25	4247	c.4011delA	c.(4009-4011)AAAfs	p.K1337fs	CACNA1A_uc010xnd.1_Frame_Shift_Del_p.K42fs|CACNA1A_uc002mwx.3_Frame_Shift_Del_p.K42fs|CACNA1A_uc010dzc.2_Frame_Shift_Del_p.K862fs|CACNA1A_uc002mwy.3_Frame_Shift_Del_p.K1336fs|CACNA1A_uc010xne.1_Frame_Shift_Del_p.K865fs	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	1337	III.|Extracellular (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)											OREG0025294	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
CACNA1A	773	broad.mit.edu	37	19	13395850	13395850	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:13395850delC	uc010dze.2	-						CACNA1A_uc010dzc.2_Intron|CACNA1A_uc002mwy.3_Intron|CACNA1A_uc010xne.1_Intron	NM_001127221	NP_001120693			calcium channel, alpha 1A subunit isoform 3						cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)													---	---	---	---
CC2D1A	54862	broad.mit.edu	37	19	14030491	14030491	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:14030491delA	uc002mxo.2	+						CC2D1A_uc002mxn.2_Intron|CC2D1A_uc002mxp.2_Intron|CC2D1A_uc010dzh.2_Intron|CC2D1A_uc002mxq.1_Intron	NM_017721	NP_060191			coiled-coil and C2 domain containing 1A						positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity				0			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)															---	---	---	---
DCAF15	90379	broad.mit.edu	37	19	14067112	14067112	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:14067112delC	uc002mxt.2	+						PODNL1_uc010xnj.1_5'Flank|PODNL1_uc002mxs.2_5'Flank	NM_138353	NP_612362			DDB1 and CUL4 associated factor 15											central_nervous_system(1)	1																		---	---	---	---
CD97	976	broad.mit.edu	37	19	14516481	14516481	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:14516481delG	uc002myl.2	+						CD97_uc002mym.2_Intron|CD97_uc002myn.2_Intron	NM_078481	NP_510966			CD97 antigen isoform 1 precursor						cell adhesion|cell-cell signaling|cellular component movement|immune response|inflammatory response|neuropeptide signaling pathway	extracellular space|integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(3)|breast(1)	4																		---	---	---	---
Unknown	0	broad.mit.edu	37	19	15694556	15694556	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:15694556delT								CYP4F22 (31429 upstream) : CYP4F8 (31473 downstream)																																			---	---	---	---
AP1M1	8907	broad.mit.edu	37	19	16320150	16320150	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:16320150delT	uc002ndu.2	+						AP1M1_uc002ndv.2_Intron|AP1M1_uc010xpd.1_Intron	NM_032493	NP_115882			adaptor-related protein complex 1, mu 1 subunit						cellular membrane organization|endosome to melanosome transport|interspecies interaction between organisms|intracellular protein transport|melanosome organization|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding			ovary(3)|breast(1)	4																		---	---	---	---
UNC13A	23025	broad.mit.edu	37	19	17750846	17750846	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17750846delT	uc002nhd.2	-							NM_001080421	NP_001073890			unc-13 homolog A						exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3																		---	---	---	---
KCNN1	3780	broad.mit.edu	37	19	18084793	18084793	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:18084793delC	uc002nht.2	+	3	406	c.96delC	c.(94-96)CACfs	p.H32fs	KCNN1_uc010xqa.1_Frame_Shift_Del_p.H32fs	NM_002248	NP_002239	Q92952	KCNN1_HUMAN	potassium intermediate/small conductance	32					synaptic transmission	voltage-gated potassium channel complex	calmodulin binding|small conductance calcium-activated potassium channel activity				0																		---	---	---	---
ELL	8178	broad.mit.edu	37	19	18561518	18561519	+	Frame_Shift_Del	DEL	CA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:18561518_18561519delCA	uc002njh.2	-	8	1305_1306	c.1233_1234delTG	c.(1231-1236)TGTGAGfs	p.C411fs	ELL_uc010ebq.2_Frame_Shift_Del_p.C354fs|ELL_uc002njg.2_Frame_Shift_Del_p.C278fs	NM_006532	NP_006523	P55199	ELL_HUMAN	elongation factor RNA polymerase II	411_412					positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	Cajal body|nuclear speck|transcription elongation factor complex	protein binding			lung(1)	1				GBM - Glioblastoma multiforme(1328;7.81e-07)				T	MLL	AL								---	---	---	---
FKBP8	23770	broad.mit.edu	37	19	18649226	18649226	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:18649226delG	uc002njk.1	-	5	682	c.569delC	c.(568-570)CCGfs	p.P190fs	FKBP8_uc002nji.1_Frame_Shift_Del_p.P28fs|FKBP8_uc010xqi.1_Frame_Shift_Del_p.P219fs|FKBP8_uc002njj.1_Frame_Shift_Del_p.P191fs|FKBP8_uc002njl.1_Frame_Shift_Del_p.P191fs|FKBP8_uc002njm.1_Frame_Shift_Del_p.P190fs|FKBP8_uc010ebr.1_Frame_Shift_Del_p.P29fs|FKBP8_uc002njn.2_RNA	NM_012181	NP_036313	Q14318	FKBP8_HUMAN	FK506-binding protein 8	190	PPIase FKBP-type.				apoptosis|interspecies interaction between organisms|intracellular signal transduction|protein folding	integral to endoplasmic reticulum membrane|mitochondrial membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|protein binding			ovary(1)	1																		---	---	---	---
CRLF1	9244	broad.mit.edu	37	19	18707343	18707343	+	Intron	DEL	A	-	-	rs78616489		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:18707343delA	uc010ebt.1	-							NM_004750	NP_004741			cytokine receptor-like factor 1 precursor						negative regulation of neuron apoptosis|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	cytokine binding|protein heterodimerization activity|receptor activity			central_nervous_system(1)	1																		---	---	---	---
CRTC1	23373	broad.mit.edu	37	19	18887993	18887993	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:18887993delC	uc002nkb.3	+	14	1794	c.1706delC	c.(1705-1707)TCCfs	p.S569fs	CRTC1_uc010ebv.2_Frame_Shift_Del_p.S585fs|CRTC1_uc010ebw.2_Frame_Shift_Del_p.S405fs|CRTC1_uc002nkc.3_Frame_Shift_Del_p.S267fs	NM_015321	NP_056136	Q6UUV9	CRTC1_HUMAN	mucoepidermoid carcinoma translocated 1 isoform	569					interspecies interaction between organisms|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	cAMP response element binding protein binding|protein binding		CRTC1/MAML2(516)	salivary_gland(474)|lung(35)|thyroid(4)|breast(3)|skin(2)|ovary(1)	519																		---	---	---	---
MEF2B	100271849	broad.mit.edu	37	19	19260991	19260992	+	Intron	INS	-	GGAA	GGAA	rs149279209	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19260991_19260992insGGAA	uc002nlm.2	-						MEF2B_uc002nln.2_Intron|MEF2B_uc002nll.2_Intron|LOC729991-MEF2B_uc010xqo.1_Intron|LOC729991-MEF2B_uc010xqp.1_Intron|LOC729991-MEF2B_uc002nlo.2_Intron|LOC729991-MEF2B_uc002nlp.2_Intron|MEF2B_uc002nlk.2_Intron	NM_001145785	NP_001139257			myocyte enhancer factor 2B isoform a											skin(1)	1			OV - Ovarian serous cystadenocarcinoma(5;0.00011)|Epithelial(12;0.00412)															---	---	---	---
LOC729991-MEF2B	4207	broad.mit.edu	37	19	19288505	19288505	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19288505delG	uc010xqo.1	-						LOC729991-MEF2B_uc010xqp.1_Intron|LOC729991-MEF2B_uc002nlo.2_Intron|LOC729991-MEF2B_uc002nlp.2_Intron|LOC729991_uc002nlq.2_Intron	NM_005919	NP_005910			myocyte enhancer factor 2B isoform b						muscle organ development	transcription factor complex	histone deacetylase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0																		---	---	---	---
GATAD2A	54815	broad.mit.edu	37	19	19606517	19606517	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19606517delG	uc010xqt.1	+						GATAD2A_uc010xqu.1_Intron|GATAD2A_uc010xqv.1_Intron|GATAD2A_uc010xqw.1_Intron	NM_017660	NP_060130			GATA zinc finger domain containing 2A						DNA methylation|negative regulation of transcription, DNA-dependent	nuclear speck|NuRD complex	protein binding, bridging|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	19	20047790	20047790	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:20047790delA								ZNF93 (2025 upstream) : ZNF682 (67439 downstream)																																			---	---	---	---
ZNF90	7643	broad.mit.edu	37	19	20228702	20228702	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:20228702delA	uc002nor.2	+	4	478	c.339delA	c.(337-339)TTAfs	p.L113fs	ZNF90_uc002nos.1_Intron|ZNF90_uc002not.1_Intron	NM_007138	NP_009069	Q03938	ZNF90_HUMAN	zinc finger protein 90	113						Golgi apparatus|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2																		---	---	---	---
ZNF90	7643	broad.mit.edu	37	19	20236400	20236400	+	RNA	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:20236400delT	uc002nos.1	+	5		c.1076delT			ZNF90_uc002not.1_RNA					Synthetic construct DNA, clone: pF1KB9685, Homo sapiens ZNF90 gene for zinc finger protein 90, without stop codon, in Flexi system.							Golgi apparatus|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	19	20262850	20262850	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:20262850delT								ZNF90 (24965 upstream) : ZNF486 (15233 downstream)																																			---	---	---	---
ZNF486	90649	broad.mit.edu	37	19	20294985	20294985	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:20294985delT	uc002nou.2	+							NM_052852	NP_443084			zinc finger protein 486						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	19	20442507	20442507	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:20442507delT								LOC284441 (72004 upstream) : ZNF826 (8571 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	19	20442697	20442697	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:20442697delT								LOC284441 (72194 upstream) : ZNF826 (8381 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	19	20635101	20635102	+	IGR	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:20635101_20635102insT								ZNF826 (27339 upstream) : ZNF737 (85697 downstream)																																			---	---	---	---
ZNF430	80264	broad.mit.edu	37	19	21239294	21239295	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:21239294_21239295delAA	uc002npj.2	+						ZNF430_uc002npk.2_Intron	NM_025189	NP_079465			zinc finger protein 430						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	19	22398402	22398403	+	IGR	DEL	CT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:22398402_22398403delCT								ZNF676 (18649 upstream) : ZNF98 (175496 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	19	23309536	23309536	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:23309536delT	uc002nrb.1	+											Homo sapiens cDNA FLJ16640 fis, clone TESTI4028938, moderately similar to Zinc finger protein 85.																														---	---	---	---
ZNF681	148213	broad.mit.edu	37	19	23938518	23938518	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:23938518delT	uc002nrk.3	-						ZNF681_uc002nrl.3_Intron|ZNF681_uc002nrj.3_Intron|ZNF681_uc002nrm.1_5'Flank	NM_138286	NP_612143			zinc finger protein 681						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)																---	---	---	---
C19orf2	8725	broad.mit.edu	37	19	30447914	30447914	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:30447914delA	uc002nsr.2	+						C19orf2_uc002nsq.2_Intron|C19orf2_uc002nss.2_Intron	NM_003796	NP_003787			RPB5-mediating protein isoform a						protein folding|regulation of transcription from RNA polymerase II promoter|response to virus	DNA-directed RNA polymerase II, core complex|prefoldin complex	transcription corepressor activity|unfolded protein binding			ovary(1)|kidney(1)	2	Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)	Hepatocellular(1079;0.137)|Renal(1328;0.228)	STAD - Stomach adenocarcinoma(5;5.36e-06)|Lung(7;0.0144)|LUAD - Lung adenocarcinoma(5;0.115)	STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
Unknown	0	broad.mit.edu	37	19	31576892	31576892	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:31576892delT								ZNF536 (527927 upstream) : DKFZp566F0947 (63891 downstream)																																			---	---	---	---
SLC7A10	56301	broad.mit.edu	37	19	33702656	33702656	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:33702656delG	uc002num.2	-						SLC7A10_uc002nul.2_5'Flank|SLC7A10_uc010xrq.1_3'UTR	NM_019849	NP_062823			solute carrier family 7, member 10						blood coagulation|cellular nitrogen compound metabolic process|ion transport|leukocyte migration	integral to plasma membrane	L-serine transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(110;0.137)																	---	---	---	---
RBM42	79171	broad.mit.edu	37	19	36123752	36123753	+	Intron	DEL	CA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36123752_36123753delCA	uc002oan.2	+						RBM42_uc010eef.2_Intron|RBM42_uc002oao.2_Intron|RBM42_uc002oap.2_Intron|RBM42_uc002oaq.2_Intron|RBM42_uc010eeg.2_Intron	NM_024321	NP_077297			RNA binding motif protein 42							cytoplasm|nucleus	nucleotide binding|RNA binding				0	all_lung(56;1.58e-07)|Lung NSC(56;2.43e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)															---	---	---	---
MLL4	9757	broad.mit.edu	37	19	36223002	36223002	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36223002delG	uc010eei.2	+	28	5631	c.5631delG	c.(5629-5631)TTGfs	p.L1877fs		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	1877					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)															---	---	---	---
CAPNS1	826	broad.mit.edu	37	19	36631885	36631885	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36631885delT	uc002odj.2	+						CAPNS1_uc002odi.1_Intron|CAPNS1_uc002odk.2_Intron|CAPNS1_uc002odl.2_Intron	NM_001749	NP_001740			calpain, small subunit 1						positive regulation of cell proliferation	cytoplasm|plasma membrane	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity				0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)															---	---	---	---
Unknown	0	broad.mit.edu	37	19	37550478	37550478	+	IGR	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:37550478delG								ZNF568 (61644 upstream) : ZNF420 (18904 downstream)																																			---	---	---	---
ZNF569	148266	broad.mit.edu	37	19	37916539	37916539	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:37916539delT	uc002ogi.2	-						ZNF569_uc002ogh.2_Intron|ZNF569_uc002ogj.2_Intron	NM_152484	NP_689697			zinc finger protein 569						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)															---	---	---	---
SIPA1L3	23094	broad.mit.edu	37	19	38610300	38610300	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:38610300delG	uc002ohk.2	+	9	3155	c.2646delG	c.(2644-2646)CAGfs	p.Q882fs		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	882					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)															---	---	---	---
RYR1	6261	broad.mit.edu	37	19	39023299	39023299	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:39023299delC	uc002oit.2	+						RYR1_uc002oiu.2_Intron|RYR1_uc002oiv.1_Intron|RYR1_uc010xuf.1_Intron	NM_000540	NP_000531			skeletal muscle ryanodine receptor isoform 1						muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)													---	---	---	---
HNRNPL	3191	broad.mit.edu	37	19	39330959	39330959	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:39330959delG	uc010xul.1	-	8	1021	c.1010delC	c.(1009-1011)CCAfs	p.P337fs	HNRNPL_uc010ege.1_5'UTR|HNRNPL_uc002ojj.1_5'UTR|HNRNPL_uc002ojo.1_5'Flank|HNRNPL_uc002ojk.2_5'UTR|HNRNPL_uc002ojl.2_5'UTR|HNRNPL_uc010xum.1_Frame_Shift_Del_p.P204fs|HNRNPL_uc002ojp.1_5'UTR|HNRNPL_uc010xun.1_Frame_Shift_Del_p.H45fs	NM_001533	NP_001524	P14866	HNRPL_HUMAN	heterogeneous nuclear ribonucleoprotein L	337	Pro-rich.				nuclear mRNA splicing, via spliceosome	cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|transcription regulatory region DNA binding				0	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)															---	---	---	---
DYRK1B	9149	broad.mit.edu	37	19	40320999	40320999	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:40320999delG	uc002omj.2	-						DYRK1B_uc002omi.2_Intron|DYRK1B_uc002omk.2_Intron|DYRK1B_uc002oml.2_Frame_Shift_Del_p.H130fs	NM_004714	NP_004705			dual-specificity tyrosine-(Y)-phosphorylation						positive regulation of transcription, DNA-dependent	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|transcription coactivator activity			ovary(4)|stomach(1)|central_nervous_system(1)|skin(1)	7	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)		Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)															---	---	---	---
PLD3	23646	broad.mit.edu	37	19	40873490	40873490	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:40873490delA	uc002onm.3	+						PLD3_uc002onj.3_Intron|PLD3_uc002onk.3_Intron|PLD3_uc002onl.3_Intron|PLD3_uc002onn.2_Intron|PLD3_uc002ono.2_3'UTR	NM_001031696	NP_001026866			phospholipase D3						lipid catabolic process	endoplasmic reticulum membrane|integral to membrane	NAPE-specific phospholipase D activity|phospholipase D activity|protein binding			skin(2)|ovary(1)	3			Lung(22;0.000636)|LUSC - Lung squamous cell carcinoma(20;0.00248)															---	---	---	---
PLD3	23646	broad.mit.edu	37	19	40884229	40884229	+	3'UTR	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:40884229delC	uc002onm.3	+	13					PLD3_uc002onj.3_3'UTR|PLD3_uc002onk.3_3'UTR|PLD3_uc002onl.3_3'UTR|PLD3_uc002onn.2_3'UTR	NM_001031696	NP_001026866			phospholipase D3						lipid catabolic process	endoplasmic reticulum membrane|integral to membrane	NAPE-specific phospholipase D activity|phospholipase D activity|protein binding			skin(2)|ovary(1)	3			Lung(22;0.000636)|LUSC - Lung squamous cell carcinoma(20;0.00248)															---	---	---	---
SPTBN4	57731	broad.mit.edu	37	19	41007576	41007576	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41007576delA	uc002ony.2	+						SPTBN4_uc002onx.2_Intron|SPTBN4_uc002onz.2_Intron	NM_020971	NP_066022			spectrin, beta, non-erythrocytic 4 isoform						actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)															---	---	---	---
ARHGEF1	9138	broad.mit.edu	37	19	42407087	42407087	+	Intron	DEL	T	-	-	rs76291947		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42407087delT	uc002orx.2	+						ARHGEF1_uc002ory.2_Intron|ARHGEF1_uc002orz.2_Intron|ARHGEF1_uc002osa.2_Intron|ARHGEF1_uc002osb.2_Intron|ARHGEF1_uc002osc.2_Intron|ARHGEF1_uc002osd.2_Intron|ARHGEF1_uc002ose.2_Intron	NM_004706	NP_004697			Rho guanine nucleotide exchange factor 1 isoform						cell proliferation|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(3)|large_intestine(1)	4		Renal(1328;0.000518)|Hepatocellular(1079;0.0046)|Medulloblastoma(540;0.0425)		Epithelial(262;5.89e-46)|GBM - Glioblastoma multiforme(1328;2.49e-12)|STAD - Stomach adenocarcinoma(1328;0.00644)														---	---	---	---
CEACAM1	634	broad.mit.edu	37	19	43016797	43016797	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:43016797delT	uc002otv.2	-						uc010eif.1_Intron|uc002ott.1_Intron|uc010eig.1_Intron|uc010eih.1_Intron|CEACAM1_uc010eii.2_Intron|CEACAM1_uc002otw.2_Intron|CEACAM1_uc010eij.2_Intron|CEACAM1_uc002otx.2_Intron|CEACAM1_uc002oty.2_Intron|CEACAM1_uc002otz.2_Intron|CEACAM1_uc010eik.2_Intron	NM_001712	NP_001703			carcinoembryonic antigen-related cell adhesion						angiogenesis|cell migration|homophilic cell adhesion|integrin-mediated signaling pathway	extracellular region|integral to plasma membrane|membrane fraction				ovary(1)|central_nervous_system(1)	2		Prostate(69;0.00682)		GBM - Glioblastoma multiforme(486;0.00148)	Arcitumomab(DB00113)													---	---	---	---
Unknown	0	broad.mit.edu	37	19	43124783	43124783	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:43124783delT	uc010eif.1	+						uc010eig.1_Intron|uc010eih.1_Intron					Homo sapiens cDNA FLJ39530 fis, clone PUAEN2004400.																														---	---	---	---
PSG1	5669	broad.mit.edu	37	19	43356908	43356908	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:43356908delT	uc010eio.1	-						PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG8_uc002oul.3_Intron|PSG8_uc002oum.3_Intron|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Intron|PSG10_uc010eip.2_Intron|PSG1_uc002our.1_Intron|PSG1_uc002oux.1_Intron|PSG1_uc002ouy.1_Intron	NM_006905	NP_008836			pregnancy specific beta-1-glycoprotein 1						female pregnancy	extracellular region				ovary(2)	2		Prostate(69;0.00682)																---	---	---	---
PSG6	5675	broad.mit.edu	37	19	43440068	43440069	+	Intron	DEL	AC	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:43440068_43440069delAC	uc002ovh.1	-						PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG7_uc002ovl.3_Intron|PSG7_uc010xwl.1_Intron					SubName: Full=Putative uncharacterized protein PSG6;						female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)																---	---	---	---
PSG6	5675	broad.mit.edu	37	19	43460948	43460948	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:43460948delA	uc002ovh.1	-						PSG11_uc002ouw.2_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron					SubName: Full=Putative uncharacterized protein PSG6;						female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)																---	---	---	---
Unknown	0	broad.mit.edu	37	19	44209094	44209094	+	IGR	DEL	T	-	-	rs112090823		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:44209094delT								PLAUR (34592 upstream) : IRGC (11120 downstream)																																			---	---	---	---
ZNF233	353355	broad.mit.edu	37	19	44768591	44768591	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:44768591delT	uc002oyz.1	+						ZNF235_uc002oyx.1_Intron|ZNF235_uc010eji.2_Intron|ZNF233_uc002oyy.1_Intron	NM_181756	NP_861421			zinc finger protein 233						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2		Prostate(69;0.0435)|all_neural(266;0.226)																---	---	---	---
ZNF233	353355	broad.mit.edu	37	19	44776904	44776905	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:44776904_44776905insA	uc002oyz.1	+						ZNF235_uc002oyx.1_Intron|ZNF235_uc010eji.2_Intron|ZNF233_uc002oyy.1_Intron	NM_181756	NP_861421			zinc finger protein 233						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2		Prostate(69;0.0435)|all_neural(266;0.226)																---	---	---	---
ZNF235	9310	broad.mit.edu	37	19	44793456	44793456	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:44793456delC	uc002oza.3	-						ZNF235_uc002oyx.1_Intron|ZNF235_uc010eji.2_Intron|ZNF235_uc002ozb.3_Intron|ZNF235_uc010xwx.1_Intron	NM_004234	NP_004225			zinc finger protein 93 homolog						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)	3		Prostate(69;0.0352)|all_neural(266;0.116)																---	---	---	---
PVR	5817	broad.mit.edu	37	19	45152947	45152947	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:45152947delC	uc002ozm.2	+						PVR_uc010ejs.2_Intron|PVR_uc010xxb.1_Intron|PVR_uc010xxc.1_Intron|PVR_uc002ozn.2_Intron	NM_006505	NP_006496			poliovirus receptor isoform alpha						adherens junction organization|cell adhesion|cell junction assembly|interspecies interaction between organisms|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity	cell junction|cell surface|cytoplasm|extracellular space|integral to membrane|nucleus	cell adhesion molecule binding|receptor activity				0	Lung NSC(12;0.00608)|all_lung(12;0.0148)	Medulloblastoma(540;0.0425)|Ovarian(192;0.0728)|Prostate(69;0.081)|all_neural(266;0.112)		Epithelial(262;0.000601)														---	---	---	---
BCAM	4059	broad.mit.edu	37	19	45317577	45317577	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:45317577delC	uc002ozu.2	+						BCAM_uc002ozt.1_Intron	NM_005581	NP_005572			basal cell adhesion molecule isoform 1						cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			skin(1)	1	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)																---	---	---	---
APOC4	346	broad.mit.edu	37	19	45448708	45448708	+	3'UTR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:45448708delA	uc002pag.1	+	3					APOC2_uc002pah.2_5'Flank	NM_001646	NP_001637			apolipoprotein C-IV precursor						lipid metabolic process|positive regulation of sequestering of triglyceride|triglyceride homeostasis	high-density lipoprotein particle|very-low-density lipoprotein particle	lipid transporter activity			breast(1)	1	Lung NSC(12;0.00858)|all_lung(12;0.0197)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00334)|Epithelial(262;0.178)														---	---	---	---
RELB	5971	broad.mit.edu	37	19	45515357	45515357	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:45515357delC	uc002paj.1	+	5	453	c.327delC	c.(325-327)TGCfs	p.C109fs		NM_006509	NP_006500	Q01201	RELB_HUMAN	reticuloendotheliosis viral oncogene homolog B	109						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00986)														---	---	---	---
MARK4	57787	broad.mit.edu	37	19	45767749	45767749	+	Intron	DEL	A	-	-	rs77123461		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:45767749delA	uc002pbb.1	+						MARK4_uc002paz.1_Intron|MARK4_uc002pba.1_Intron|MARK4_uc002pbc.1_5'Flank					RecName: Full=MAP/microtubule affinity-regulating kinase 4;          EC=2.7.11.1; AltName: Full=MAP/microtubule affinity-regulating kinase-like 1;						microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			central_nervous_system(2)|large_intestine(1)	3		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)														---	---	---	---
Unknown	0	broad.mit.edu	37	19	45833506	45833506	+	IGR	DEL	T	-	-	rs71338768		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:45833506delT								CKM (7372 upstream) : KLC3 (10492 downstream)																																			---	---	---	---
KLC3	147700	broad.mit.edu	37	19	45852955	45852955	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:45852955delG	uc002pbf.1	+						KLC3_uc010ejy.1_Intron|KLC3_uc002pbg.1_Intron	NM_177417	NP_803136			kinesin light chain 3							cytoplasm|kinesin complex|microtubule	microtubule motor activity			ovary(1)	1		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)														---	---	---	---
FOSB	2354	broad.mit.edu	37	19	45973862	45973863	+	Intron	DEL	TG	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:45973862_45973863delTG	uc002pbx.3	+						ERCC1_uc002pbu.1_Intron|FOSB_uc002pbw.2_Intron|FOSB_uc010eke.2_Intron|FOSB_uc002pby.3_Intron|FOSB_uc010eka.1_Intron|FOSB_uc010ekb.1_Intron|FOSB_uc010ekc.1_Intron|FOSB_uc010ekf.2_Intron|FOSB_uc010ekd.1_Intron|FOSB_uc010ekg.2_Intron|FOSB_uc002pca.3_5'UTR	NM_006732	NP_006723			FBJ murine osteosarcoma viral oncogene homolog B						behavior|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(2)|lung(1)	3		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00814)|Epithelial(262;0.18)|GBM - Glioblastoma multiforme(486;0.242)														---	---	---	---
QPCTL	54814	broad.mit.edu	37	19	46198544	46198544	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:46198544delA	uc010xxr.1	+						QPCTL_uc010ekn.2_Intron	NM_017659	NP_060129			glutaminyl-peptide cyclotransferase-like isoform						peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase|proteolysis	Golgi membrane|integral to membrane	acyltransferase activity|glutaminyl-peptide cyclotransferase activity|peptidase activity|protein binding|zinc ion binding			skin(1)	1		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0059)|GBM - Glioblastoma multiforme(486;0.0882)|Epithelial(262;0.208)														---	---	---	---
FBXO46	23403	broad.mit.edu	37	19	46216274	46216274	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:46216274delG	uc002pcy.2	-	2	605	c.480delC	c.(478-480)CCCfs	p.P160fs	FBXO46_uc002pcz.2_Frame_Shift_Del_p.P160fs	NM_001080469	NP_001073938	Q6PJ61	FBX46_HUMAN	F-box protein 46	160							protein binding			ovary(1)|lung(1)|breast(1)	3		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00568)|GBM - Glioblastoma multiforme(486;0.0844)|Epithelial(262;0.201)														---	---	---	---
IRF2BP1	26145	broad.mit.edu	37	19	46388666	46388666	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:46388666delG	uc002pds.1	-	1	711	c.367delC	c.(367-369)CTGfs	p.L123fs		NM_015649	NP_056464	Q8IU81	I2BP1_HUMAN	interferon regulatory factor 2 binding protein	123					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0402)|Epithelial(262;0.231)														---	---	---	---
Unknown	0	broad.mit.edu	37	19	46846833	46846833	+	IGR	DEL	T	-	-	rs112154378		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:46846833delT								HIF3A (144 upstream) : PPP5C (3461 downstream)																																			---	---	---	---
AP2S1	1175	broad.mit.edu	37	19	47342148	47342148	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:47342148delA	uc002pft.1	-						AP2S1_uc002pfu.1_Intron	NM_004069	NP_004060			adaptor-related protein complex 2, sigma 1						axon guidance|clathrin coat assembly|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|regulation of endocytosis|synaptic transmission|viral reproduction	AP-2 adaptor complex|cytosol	protein transporter activity				0		all_cancers(25;1.24e-06)|all_epithelial(76;1.09e-05)|all_lung(116;0.00019)|Lung NSC(112;0.000601)|Ovarian(192;0.0221)|all_neural(266;0.0459)|Breast(70;0.128)		OV - Ovarian serous cystadenocarcinoma(262;3.86e-05)|all cancers(93;0.000107)|Epithelial(262;0.00325)|GBM - Glioblastoma multiforme(486;0.0336)														---	---	---	---
EHD2	30846	broad.mit.edu	37	19	48239465	48239466	+	Intron	DEL	AG	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:48239465_48239466delAG	uc002phj.3	+						EHD2_uc010xyu.1_Intron|EHD2_uc010xyv.1_Intron	NM_014601	NP_055416			EH-domain containing 2						blood coagulation|endocytic recycling	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding			ovary(1)|skin(1)	2		all_cancers(25;6.74e-07)|all_lung(116;2.02e-05)|Lung NSC(112;3.77e-05)|all_epithelial(76;4.89e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		OV - Ovarian serous cystadenocarcinoma(262;0.000336)|all cancers(93;0.000415)|Epithelial(262;0.0132)|GBM - Glioblastoma multiforme(486;0.0537)														---	---	---	---
CABP5	56344	broad.mit.edu	37	19	48537535	48537535	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:48537535delG	uc002phu.1	-	5	558	c.433delC	c.(433-435)CGGfs	p.R145fs		NM_019855	NP_062829	Q9NP86	CABP5_HUMAN	calcium binding protein 5	145	EF-hand 4.				signal transduction	cytoplasm	calcium ion binding			skin(1)	1		all_cancers(25;1.86e-08)|all_lung(116;1.14e-06)|all_epithelial(76;1.16e-06)|Lung NSC(112;2.54e-06)|all_neural(266;0.0138)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;4.09e-05)|all cancers(93;0.000322)|Epithelial(262;0.01)|GBM - Glioblastoma multiforme(486;0.058)														---	---	---	---
LIG1	3978	broad.mit.edu	37	19	48654327	48654327	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:48654327delA	uc002pia.1	-						LIG1_uc010xze.1_Intron|LIG1_uc002phz.1_Intron|LIG1_uc002pib.1_Intron|LIG1_uc010xzf.1_Intron|LIG1_uc010xzg.1_Intron|LIG1_uc010xzh.1_Intron	NM_000234	NP_000225			DNA ligase I						anatomical structure morphogenesis|base-excision repair|cell division|DNA ligation involved in DNA repair|DNA strand elongation involved in DNA replication|double-strand break repair via homologous recombination|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding			large_intestine(2)|lung(1)	3		all_epithelial(76;3.1e-06)|all_lung(116;4.39e-06)|Lung NSC(112;8.96e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;8.45e-05)|all cancers(93;0.000423)|Epithelial(262;0.0177)|GBM - Glioblastoma multiforme(486;0.0329)	Bleomycin(DB00290)								NER					---	---	---	---
SEC1	653677	broad.mit.edu	37	19	49142123	49142123	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49142123delG	uc010xzv.1	+						SEC1_uc002pka.2_Intron|SEC1_uc010xzw.1_Intron|SEC1_uc010ema.2_Intron|DBP_uc002pjx.3_5'Flank|DBP_uc002pjy.2_5'Flank|DBP_uc010elz.1_5'Flank|CA11_uc002pjz.1_Intron	NR_004401				SubName: Full=cDNA FLJ58287, highly similar to Galactoside 2-alpha-L-fucosyltransferase 2 (EC 2.4.1.69);												0																		---	---	---	---
IZUMO1	284359	broad.mit.edu	37	19	49247467	49247467	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49247467delA	uc002pkj.2	-						IZUMO1_uc010eme.2_Intron|IZUMO1_uc010emf.2_Intron	NM_182575	NP_872381			izumo sperm-egg fusion 1 precursor						fusion of sperm to egg plasma membrane	integral to membrane				ovary(1)	1		all_lung(116;0.000156)|Lung NSC(112;0.000251)|all_epithelial(76;0.000761)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000348)|Epithelial(262;0.019)|GBM - Glioblastoma multiforme(486;0.022)														---	---	---	---
PRR12	57479	broad.mit.edu	37	19	50128883	50128883	+	3'UTR	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50128883delG	uc002poo.3	+	14						NM_020719	NP_065770			proline rich 12								DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)														---	---	---	---
PNKP	11284	broad.mit.edu	37	19	50364837	50364837	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50364837delG	uc002pqh.2	-						PNKP_uc002pqg.2_Intron|PNKP_uc002pqi.2_Intron|PNKP_uc002pqj.2_Intron|PNKP_uc010enm.2_Intron|PNKP_uc002pqk.2_Intron	NM_007254	NP_009185			polynucleotide kinase 3' phosphatase						DNA damage response, detection of DNA damage|DNA-dependent DNA replication|nucleotide-excision repair, DNA damage removal|response to oxidative stress|response to radiation	nucleolus	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|damaged DNA binding|double-stranded DNA binding|endonuclease activity|nucleotide kinase activity|polynucleotide 3'-phosphatase activity|protein binding			ovary(1)|kidney(1)	2		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0118)|OV - Ovarian serous cystadenocarcinoma(262;0.0134)									Other_BER_factors					---	---	---	---
IL4I1	259307	broad.mit.edu	37	19	50392802	50392803	+	3'UTR	INS	-	GG	GG			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50392802_50392803insGG	uc002pqv.1	-	11					IL4I1_uc010eno.1_3'UTR|IL4I1_uc002pqw.1_3'UTR	NM_152899	NP_690863			interleukin 4 induced 1 isoform 1 precursor							lysosome	L-amino-acid oxidase activity			lung(1)|ovary(1)|prostate(1)	3		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00245)|OV - Ovarian serous cystadenocarcinoma(262;0.0169)														---	---	---	---
MYH14	79784	broad.mit.edu	37	19	50760525	50760526	+	Intron	INS	-	TC	TC			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50760525_50760526insTC	uc002prr.1	+						MYH14_uc010enu.1_Intron|MYH14_uc002prq.1_Intron	NM_024729	NP_079005			myosin, heavy chain 14 isoform 2						axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)	1		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)														---	---	---	---
MYBPC2	4606	broad.mit.edu	37	19	50946648	50946649	+	Intron	DEL	GA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50946648_50946649delGA	uc002psf.2	+							NM_004533	NP_004524			myosin binding protein C, fast type						cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)														---	---	---	---
Unknown	0	broad.mit.edu	37	19	51906670	51906670	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:51906670delT								LIM2 (15460 upstream) : SIGLEC10 (6606 downstream)																																			---	---	---	---
ZNF766	90321	broad.mit.edu	37	19	52780712	52780712	+	Intron	DEL	A	-	-	rs79554348		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:52780712delA	uc002pyr.1	+						ZNF766_uc002pys.1_Intron|ZNF766_uc002pyt.1_5'UTR	NM_001010851	NP_001010851			zinc finger protein 766						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00236)|OV - Ovarian serous cystadenocarcinoma(262;0.00871)														---	---	---	---
ZNF480	147657	broad.mit.edu	37	19	52819262	52819262	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:52819262delT	uc010ydl.1	+						ZNF480_uc002pyv.2_Intron|ZNF480_uc010ydm.1_Intron|ZNF480_uc010epn.2_Intron|uc002pyw.1_Intron	NM_144684	NP_653285			zinc finger protein 480						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00212)|OV - Ovarian serous cystadenocarcinoma(262;0.00369)														---	---	---	---
Unknown	0	broad.mit.edu	37	19	53366062	53366062	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:53366062delA								ZNF468 (5160 upstream) : ZNF320 (1057 downstream)																																			---	---	---	---
ZNF160	90338	broad.mit.edu	37	19	53573669	53573670	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:53573669_53573670delTT	uc010eqk.2	-						ZNF160_uc002qaq.3_Intron|ZNF160_uc002qar.3_Intron	NM_001102603	NP_001096073			zinc finger protein 160						hemopoiesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(134;0.02)														---	---	---	---
MIR1323	100302255	broad.mit.edu	37	19	54175088	54175089	+	5'Flank	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54175088_54175089insT	hsa-mir-1323|MI0003786	+						MIR498_hsa-mir-498|MI0003142_5'Flank																	0																		---	---	---	---
MIR520E	574461	broad.mit.edu	37	19	54177772	54177772	+	5'Flank	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54177772delT	hsa-mir-520e|MI0003143	+																							0																		---	---	---	---
Unknown	0	broad.mit.edu	37	19	54279184	54279184	+	IGR	DEL	T	-	-	rs62146188		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54279184delT								MIR519A2 (13500 upstream) : MIR371 (11745 downstream)																																			---	---	---	---
TARM1	441864	broad.mit.edu	37	19	54583735	54583736	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54583735_54583736delAA	uc010yei.1	-							NM_001135686	NP_001129158			OSCAR-like transcript-2							integral to membrane					0																		---	---	---	---
PRPF31	26121	broad.mit.edu	37	19	54629881	54629881	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54629881delC	uc002qdh.2	+						PRPF31_uc010yek.1_Intron	NM_015629	NP_056444			pre-mRNA processing factor 31 homolog						assembly of spliceosomal tri-snRNP	Cajal body|MLL1 complex|nuclear speck|U4 snRNP|U4/U6 x U5 tri-snRNP complex|U4atac snRNP	RNA binding|snRNP binding			ovary(1)	1	all_cancers(19;0.00681)|all_epithelial(19;0.00362)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)																	---	---	---	---
LENG1	79165	broad.mit.edu	37	19	54660925	54660925	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54660925delG	uc002qdm.2	-							NM_024316	NP_077292			leukocyte receptor cluster (LRC) member 1											ovary(1)	1	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)																	---	---	---	---
LENG8	114823	broad.mit.edu	37	19	54968820	54968820	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54968820delT	uc002qfv.1	+						LENG8_uc002qfw.2_Intron					RecName: Full=Leukocyte receptor cluster member 8;								protein binding			central_nervous_system(1)|pancreas(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.139)														---	---	---	---
LILRB1	10859	broad.mit.edu	37	19	55148385	55148385	+	3'UTR	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55148385delC	uc002qgj.2	+	16					LILRB1_uc002qgl.2_3'UTR|LILRB1_uc002qgk.2_3'UTR|LILRB1_uc002qgm.2_3'UTR|LILRB1_uc010erq.2_3'UTR|LILRB1_uc010err.2_RNA	NM_006669	NP_006660			leukocyte immunoglobulin-like receptor,						regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)											HNSCC(37;0.09)			---	---	---	---
Unknown	0	broad.mit.edu	37	19	55212296	55212296	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55212296delA								LILRB4 (32452 upstream) : LILRP2 (7305 downstream)																																			---	---	---	---
NLRP2	55655	broad.mit.edu	37	19	55492878	55492878	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55492878delC	uc002qij.2	+						NLRP2_uc010yfp.1_Intron|NLRP2_uc010esn.2_Intron|NLRP2_uc010eso.2_Intron|NLRP2_uc010esp.2_Intron	NM_017852	NP_060322			NLR family, pyrin domain containing 2						apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)														---	---	---	---
BRSK1	84446	broad.mit.edu	37	19	55798502	55798502	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55798502delG	uc002qkg.2	+						BRSK1_uc002qkf.2_Intron	NM_032430	NP_115806			BR serine/threonine kinase 1						establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|stomach(1)|lung(1)|breast(1)|skin(1)	6		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)														---	---	---	---
ZNF264	9422	broad.mit.edu	37	19	57724155	57724155	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:57724155delA	uc002qob.2	+	4	2103	c.1690delA	c.(1690-1692)AAAfs	p.K564fs		NM_003417	NP_003408	O43296	ZN264_HUMAN	zinc finger protein 264	564					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0135)														---	---	---	---
ZSCAN4	201516	broad.mit.edu	37	19	58188084	58188084	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58188084delA	uc002qpu.2	+							NM_152677	NP_689890			zinc finger and SCAN domain containing 4						telomere maintenance via telomere lengthening|viral reproduction	nuclear chromosome, telomeric region	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)														---	---	---	---
NOP56	10528	broad.mit.edu	37	20	2638355	2638355	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:2638355delT	uc002wgh.2	+						NOP56_uc010zpy.1_Intron|NOP56_uc002wgi.2_Intron|NOP56_uc002wgm.1_3'UTR	NM_006392	NP_006383			nucleolar protein 5A						rRNA processing	box C/D snoRNP complex|pre-snoRNP complex	protein binding|snoRNA binding			ovary(1)|pancreas(1)	2																		---	---	---	---
GNRH2	2797	broad.mit.edu	37	20	3026238	3026238	+	Intron	DEL	G	-	-	rs6138994	byFrequency;by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:3026238delG	uc002whr.1	+						GNRH2_uc002whp.1_Intron|GNRH2_uc002whq.1_Intron|GNRH2_uc010gau.1_Intron|MRPS26_uc002whs.2_5'Flank	NM_001501	NP_001492			gonadotropin-releasing hormone 2 isoform a						multicellular organismal development|signal transduction	extracellular region|soluble fraction	hormone activity				0																		---	---	---	---
OXT	5020	broad.mit.edu	37	20	3052728	3052728	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:3052728delC	uc002wht.1	+	2	162	c.126delC	c.(124-126)CTCfs	p.L42fs		NM_000915	NP_000906	P01178	NEU1_HUMAN	oxytocin-neurophysin I preproprotein	42					signal transduction		neurohypophyseal hormone activity				0					Oxytocin(DB00107)													---	---	---	---
ATRN	8455	broad.mit.edu	37	20	3562734	3562734	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:3562734delA	uc002wim.2	+						ATRN_uc002wil.2_Intron	NM_139321	NP_647537			attractin isoform 1						inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			ovary(1)|breast(1)	2																		---	---	---	---
ATRN	8455	broad.mit.edu	37	20	3565224	3565224	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:3565224delA	uc002wim.2	+						ATRN_uc002wil.2_Intron	NM_139321	NP_647537			attractin isoform 1						inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			ovary(1)|breast(1)	2																		---	---	---	---
MAVS	57506	broad.mit.edu	37	20	3843260	3843260	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:3843260delT	uc002wjw.3	+						MAVS_uc002wjx.3_Intron|MAVS_uc002wjy.3_Intron	NM_020746	NP_065797			virus-induced signaling adapter						activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity				0																		---	---	---	---
RNF24	11237	broad.mit.edu	37	20	3915479	3915480	+	Intron	DEL	CA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:3915479_3915480delCA	uc002wkh.2	-						RNF24_uc002wki.2_Intron|RNF24_uc002wkj.2_Intron	NM_007219	NP_009150			ring finger protein 24 isoform 1							Golgi membrane|integral to membrane	zinc ion binding				0																		---	---	---	---
GPCPD1	56261	broad.mit.edu	37	20	5545874	5545874	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:5545874delT	uc002wme.3	-						GPCPD1_uc002wmd.3_Intron	NM_019593	NP_062539			hypothetical protein LOC56261						glycerol metabolic process|lipid metabolic process		carbohydrate binding|glycerophosphodiester phosphodiesterase activity				0																		---	---	---	---
GPCPD1	56261	broad.mit.edu	37	20	5560876	5560876	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:5560876delT	uc002wme.3	-						GPCPD1_uc002wmd.3_Intron	NM_019593	NP_062539			hypothetical protein LOC56261						glycerol metabolic process|lipid metabolic process		carbohydrate binding|glycerophosphodiester phosphodiesterase activity				0																		---	---	---	---
PLCB1	23236	broad.mit.edu	37	20	8703048	8703048	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:8703048delA	uc002wnb.2	+	15	1564	c.1561delA	c.(1561-1563)AAAfs	p.K521fs	PLCB1_uc010zrb.1_Frame_Shift_Del_p.K420fs|PLCB1_uc002wna.2_Frame_Shift_Del_p.K521fs|PLCB1_uc002wnc.1_Frame_Shift_Del_p.K420fs|PLCB1_uc002wnd.1_Frame_Shift_Del_p.K98fs	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	521					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12																		---	---	---	---
PLCB1	23236	broad.mit.edu	37	20	8714162	8714162	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:8714162delT	uc002wnb.2	+						PLCB1_uc010zrb.1_Intron|PLCB1_uc002wna.2_Intron|PLCB1_uc002wnc.1_Intron|PLCB1_uc002wnd.1_Intron	NM_015192	NP_056007			phosphoinositide-specific phospholipase C beta 1						activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12																		---	---	---	---
PLCB4	5332	broad.mit.edu	37	20	9438188	9438188	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:9438188delT	uc002wnf.2	+						PLCB4_uc010gbx.2_Intron|PLCB4_uc002wne.2_Intron|PLCB4_uc002wnh.2_Intron	NM_182797	NP_877949			phospholipase C beta 4 isoform b						intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15																		---	---	---	---
C20orf94	128710	broad.mit.edu	37	20	10439002	10439002	+	Intron	DEL	T	-	-	rs6039947	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:10439002delT	uc010zre.1	+							NM_001009608	NP_001009608			hypothetical protein LOC128710								protein binding				0																		---	---	---	---
ESF1	51575	broad.mit.edu	37	20	13740507	13740507	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:13740507delA	uc002woj.2	-						ESF1_uc002wok.1_Intron	NM_016649	NP_057733			ABT1-associated protein						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm				ovary(1)	1																		---	---	---	---
ESF1	51575	broad.mit.edu	37	20	13752187	13752187	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:13752187delA	uc002woj.2	-						ESF1_uc002wok.1_Intron	NM_016649	NP_057733			ABT1-associated protein						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm				ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	20	19991812	19991812	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:19991812delA								RIN2 (8712 upstream) : NAA20 (6125 downstream)																																			---	---	---	---
CRNKL1	51340	broad.mit.edu	37	20	20016830	20016830	+	3'UTR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:20016830delA	uc002wrs.2	-	15						NM_016652	NP_057736			crooked neck-like 1 protein						spliceosome assembly	catalytic step 2 spliceosome|cytoplasm|nuclear speck	RNA binding			ovary(2)|large_intestine(1)	3																		---	---	---	---
XRN2	22803	broad.mit.edu	37	20	21321692	21321693	+	Intron	INS	-	GTA	GTA	rs141054974	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:21321692_21321693insGTA	uc002wsf.1	+						XRN2_uc002wsg.1_Intron|XRN2_uc010zsk.1_Intron	NM_012255	NP_036387			5'-3' exoribonuclease 2						cell growth|DNA catabolic process, exonucleolytic|mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|spermatogenesis|transcription termination, DNA-dependent	nucleolus	5'-3' exoribonuclease activity|nucleic acid binding|protein binding|zinc ion binding			skin(1)	1																		---	---	---	---
GZF1	64412	broad.mit.edu	37	20	23345195	23345195	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:23345195delT	uc010gdb.2	+	3	349	c.175delT	c.(175-177)TTTfs	p.F59fs	GZF1_uc002wsy.2_Frame_Shift_Del_p.F59fs|GZF1_uc010zsq.1_Intron|GZF1_uc010zsr.1_Intron|GZF1_uc002wsz.2_Frame_Shift_Del_p.F59fs	NM_022482	NP_071927	Q9H116	GZF1_HUMAN	GDNF-inducible zinc finger protein 1	59	BTB.				transcription, DNA-dependent	nucleolus|nucleoplasm	sequence-specific DNA binding|zinc ion binding			kidney(1)	1	Lung NSC(19;0.0605)|Colorectal(13;0.0993)|all_lung(19;0.135)																	---	---	---	---
DEFB115	245929	broad.mit.edu	37	20	29845391	29845391	+	5'Flank	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:29845391delT	uc002wvp.1	+							NM_001037730	NP_001032819			beta-defensin 115 precursor						defense response to bacterium	extracellular region				ovary(1)	1			Colorectal(19;0.00445)|COAD - Colon adenocarcinoma(19;0.0347)															---	---	---	---
Unknown	0	broad.mit.edu	37	20	29930713	29930713	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:29930713delT								DEFB116 (34325 upstream) : DEFB118 (25715 downstream)																																			---	---	---	---
ASXL1	171023	broad.mit.edu	37	20	31017181	31017182	+	Frame_Shift_Del	DEL	GA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:31017181_31017182delGA	uc002wxs.2	+	6	938_939	c.512_513delGA	c.(511-513)CGAfs	p.R171fs	ASXL1_uc010geb.2_Frame_Shift_Del_p.R113fs	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	171					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248								F|N|Mis		MDS|CMML								---	---	---	---
ASXL1	171023	broad.mit.edu	37	20	31022442	31022442	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:31022442delG	uc002wxs.2	+	12	2353	c.1927delG	c.(1927-1929)GGGfs	p.G643fs	ASXL1_uc010geb.2_Frame_Shift_Del_p.G534fs	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	643	Gly-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding	p.A640fs*14(2)|p.T639_G659>PPWD(1)|p.A640_S664>PCSGG(1)|p.T639fs*14(1)|p.T639fs*19(1)|p.T639_P647>PPSDGS(1)		haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248								F|N|Mis		MDS|CMML								---	---	---	---
EIF2S2	8894	broad.mit.edu	37	20	32684309	32684309	+	Intron	DEL	G	-	-	rs2235596	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:32684309delG	uc002xaf.2	-						EIF2S2_uc002xag.2_Intron|EIF2S2_uc010ges.2_Intron	NM_003908	NP_003899			eukaryotic translation initiation factor 2 beta							cytosol|eukaryotic translation initiation factor 2 complex	metal ion binding|protein binding|translation initiation factor activity			large_intestine(1)	1																		---	---	---	---
MYH7B	57644	broad.mit.edu	37	20	33572391	33572391	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:33572391delC	uc002xbi.1	+							NM_020884	NP_065935			myosin, heavy polypeptide 7B, cardiac muscle,							membrane|myosin filament	actin binding|ATP binding|motor activity			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00691)															---	---	---	---
GDF5	8200	broad.mit.edu	37	20	33969913	33969913	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:33969913delT	uc010gfc.1	-						UQCC_uc010zuy.1_Intron|UQCC_uc002xcd.2_Intron|UQCC_uc010zuz.1_Intron|UQCC_uc010zva.1_Intron|UQCC_uc002xce.2_Intron|UQCC_uc002xcg.2_Intron|UQCC_uc010gfb.2_Intron|UQCC_uc010zvb.1_Intron|UQCC_uc002xcf.2_Intron|UQCC_uc002xci.1_Intron|UQCC_uc010gfd.1_Intron	NM_000557	NP_000548			growth differentiation factor 5 preproprotein						cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity				0	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)															---	---	---	---
DLGAP4	22839	broad.mit.edu	37	20	35091141	35091141	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:35091141delG	uc002xff.2	+						DLGAP4_uc010zvp.1_Intron|DLGAP4_uc002xfg.2_Intron|DLGAP4_uc002xfh.2_Intron	NM_014902	NP_055717			disks large-associated protein 4 isoform a						cell-cell signaling	membrane	protein binding			skin(2)|ovary(1)	3	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)																---	---	---	---
DSN1	79980	broad.mit.edu	37	20	35395406	35395407	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:35395406_35395407delAA	uc010gfr.2	-						DSN1_uc002xfz.2_Intron|DSN1_uc002xfy.3_Intron|DSN1_uc002xga.2_Intron|DSN1_uc010zvs.1_Intron|DSN1_uc002xgc.2_Intron|DSN1_uc002xgb.2_Intron	NM_001145316	NP_001138788			DSN1, MIND kinetochore complex component,						cell division|chromosome segregation|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding			ovary(2)	2		Myeloproliferative disorder(115;0.00874)																---	---	---	---
C20orf117	140710	broad.mit.edu	37	20	35445891	35445891	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:35445891delA	uc002xgd.1	-						C20orf117_uc002xge.1_5'Flank	NM_199181	NP_954650			hypothetical protein LOC140710 isoform 2												0		Myeloproliferative disorder(115;0.00874)																---	---	---	---
SAMHD1	25939	broad.mit.edu	37	20	35526446	35526446	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:35526446delT	uc002xgh.1	-						SAMHD1_uc010gft.1_Intron	NM_015474	NP_056289			SAM domain- and HD domain-containing protein 1						defense response to virus|innate immune response|regulation of innate immune response	nucleus	metal ion binding|phosphoric diester hydrolase activity				0		Myeloproliferative disorder(115;0.00878)																---	---	---	---
KIAA0406	9675	broad.mit.edu	37	20	36627613	36627613	+	Frame_Shift_Del	DEL	G	-	-	rs149568606		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:36627613delG	uc002xhl.2	-	6	2979	c.2770delC	c.(2770-2772)CTGfs	p.L924fs	KIAA0406_uc002xhm.2_Frame_Shift_Del_p.L924fs	NM_014657	NP_055472	O43156	TTI1_HUMAN	hypothetical protein LOC9675	924							binding				0		Myeloproliferative disorder(115;0.00874)																---	---	---	---
RPRD1B	58490	broad.mit.edu	37	20	36687672	36687672	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:36687672delT	uc002xho.3	+							NM_021215	NP_067038			Regulation of nuclear pre-mRNA domain containing											pancreas(1)	1																		---	---	---	---
SEMG2	6407	broad.mit.edu	37	20	43837376	43837376	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:43837376delT	uc010ggz.2	+						SEMG1_uc002xni.2_Intron|SEMG1_uc002xnj.2_Intron|SEMG1_uc002xnh.2_Intron	NM_003008	NP_002999			semenogelin II precursor						sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(1)	1		Myeloproliferative disorder(115;0.0122)																---	---	---	---
TP53TG5	27296	broad.mit.edu	37	20	44006414	44006414	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:44006414delA	uc002xny.2	-						SYS1-DBNDD2_uc002xnx.2_Intron	NM_014477	NP_055292			TP53-target gene 5 protein						intracellular signal transduction|negative regulation of cell growth	cytoplasm|nucleus				central_nervous_system(1)	1																		---	---	---	---
ZMYND8	23613	broad.mit.edu	37	20	45867410	45867410	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:45867410delA	uc002xta.1	-						ZMYND8_uc010ghq.1_Intron|ZMYND8_uc010ghr.1_Intron|ZMYND8_uc002xst.1_Intron|ZMYND8_uc002xsu.1_Intron|ZMYND8_uc002xsv.1_Intron|ZMYND8_uc002xsw.1_Intron|ZMYND8_uc002xsx.1_Intron|ZMYND8_uc002xsy.1_Intron|ZMYND8_uc002xsz.1_Intron|ZMYND8_uc010zxy.1_Intron|ZMYND8_uc002xtb.1_Intron|ZMYND8_uc002xss.2_Intron|ZMYND8_uc010zxz.1_Intron|ZMYND8_uc002xtc.1_Intron|ZMYND8_uc002xtd.1_Intron|ZMYND8_uc002xte.1_Intron|ZMYND8_uc010zya.1_Intron|ZMYND8_uc002xtf.1_Intron|ZMYND8_uc002xtg.2_Frame_Shift_Del_p.F893fs|ZMYND8_uc010ghs.1_Frame_Shift_Del_p.F893fs|ZMYND8_uc002xsr.1_Intron	NM_012408	NP_036540			zinc finger, MYND-type containing 8 isoform b								protein binding|zinc ion binding			central_nervous_system(2)|urinary_tract(1)|ovary(1)|skin(1)	5			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)															---	---	---	---
CSE1L	1434	broad.mit.edu	37	20	47707098	47707098	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:47707098delA	uc002xty.2	+						CSE1L_uc010zyg.1_Intron|CSE1L_uc010ghx.2_Intron|CSE1L_uc010ghy.2_Intron|CSE1L_uc010zyh.1_Intron	NM_001316	NP_001307			CSE1 chromosome segregation 1-like protein						apoptosis|cell proliferation|intracellular protein transport	cytoplasm|nucleus	importin-alpha export receptor activity			large_intestine(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000491)|Colorectal(8;0.198)															---	---	---	---
DDX27	55661	broad.mit.edu	37	20	47858504	47858504	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:47858504delA	uc002xuh.2	+	17	2126	c.2065delA	c.(2065-2067)AAAfs	p.K689fs		NM_017895	NP_060365	Q96GQ7	DDX27_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 27	689						nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			kidney(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.000899)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)															---	---	---	---
TMEM189-UBE2V1	387522	broad.mit.edu	37	20	48747522	48747522	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:48747522delC	uc002xvf.2	-						TMEM189_uc010zyq.1_Intron|TMEM189_uc002xvg.2_Intron|TMEM189_uc010gif.2_Intron|TMEM189_uc010zyp.1_Intron	NM_199203	NP_954673			TMEM189-UBE2V1 readthrough transcript						cell differentiation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|protein K63-linked ubiquitination|regulation of DNA repair|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleus|UBC13-UEV1A complex|ubiquitin ligase complex	acid-amino acid ligase activity|protein binding				0			BRCA - Breast invasive adenocarcinoma(9;8.29e-07)															---	---	---	---
AURKA	6790	broad.mit.edu	37	20	54945812	54945812	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:54945812delC	uc002xxd.1	-						AURKA_uc002xxe.1_Intron|AURKA_uc002xxf.1_Intron|AURKA_uc002xxg.1_Intron|AURKA_uc002xxh.1_Intron|AURKA_uc002xxi.1_Intron|AURKA_uc002xxj.1_Intron|AURKA_uc002xxk.1_Intron|AURKA_uc010zzd.1_Intron	NM_198433	NP_940835			serine/threonine protein kinase 6						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|phosphatidylinositol-mediated signaling|regulation of protein stability|spindle organization	cytosol|nucleus|perinuclear region of cytoplasm|spindle microtubule|spindle pole centrosome	ATP binding|protein kinase binding|protein serine/threonine kinase activity			lung(3)|ovary(2)|breast(1)|large_intestine(1)|skin(1)	8			Colorectal(105;0.202)															---	---	---	---
AURKA	6790	broad.mit.edu	37	20	54959235	54959235	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:54959235delT	uc002xxd.1	-						AURKA_uc002xxe.1_Intron|AURKA_uc002xxf.1_Intron|AURKA_uc002xxg.1_Intron|AURKA_uc002xxh.1_Intron|AURKA_uc002xxi.1_Intron|AURKA_uc002xxj.1_Intron|AURKA_uc002xxk.1_Intron|AURKA_uc010zzd.1_Intron	NM_198433	NP_940835			serine/threonine protein kinase 6						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|phosphatidylinositol-mediated signaling|regulation of protein stability|spindle organization	cytosol|nucleus|perinuclear region of cytoplasm|spindle microtubule|spindle pole centrosome	ATP binding|protein kinase binding|protein serine/threonine kinase activity			lung(3)|ovary(2)|breast(1)|large_intestine(1)|skin(1)	8			Colorectal(105;0.202)															---	---	---	---
C20orf85	128602	broad.mit.edu	37	20	56726009	56726009	+	5'UTR	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:56726009delC	uc002xyv.2	+	1						NM_178456	NP_848551			hypothetical protein LOC128602											ovary(1)	1	all_epithelial(3;5.99e-14)|Lung NSC(12;0.000152)|all_lung(29;0.000518)|Melanoma(10;0.118)		BRCA - Breast invasive adenocarcinoma(13;5.53e-12)|Epithelial(14;7.42e-08)|all cancers(14;7.19e-07)															---	---	---	---
SLMO2	51012	broad.mit.edu	37	20	57610185	57610185	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:57610185delA	uc002yam.2	-						ATP5E_uc002yal.2_5'Flank|SLMO2_uc010zzv.1_Intron	NM_016045	NP_057129			slowmo homolog 2											skin(1)	1	all_lung(29;0.00711)		Colorectal(105;0.109)															---	---	---	---
SYCP2	10388	broad.mit.edu	37	20	58461024	58461024	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:58461024delA	uc002yaz.2	-							NM_014258	NP_055073			synaptonemal complex protein 2						cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			ovary(3)|lung(2)	5	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)															---	---	---	---
SYCP2	10388	broad.mit.edu	37	20	58467740	58467741	+	Frame_Shift_Ins	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:58467740_58467741insT	uc002yaz.2	-	22	1948_1949	c.1809_1810insA	c.(1807-1812)TTAGACfs	p.L603fs		NM_014258	NP_055073	Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	603_604					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			ovary(3)|lung(2)	5	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)															---	---	---	---
C20orf151	140893	broad.mit.edu	37	20	60991168	60991168	+	Intron	DEL	G	-	-	rs150469970	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:60991168delG	uc002ycw.1	-							NM_080833	NP_543023			hypothetical protein LOC140893												0	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;6.43e-06)															---	---	---	---
SLCO4A1	28231	broad.mit.edu	37	20	61299084	61299084	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:61299084delC	uc002ydb.1	+						SLCO4A1_uc002ydc.1_Intron|LOC100127888_uc002ydd.2_5'Flank|SLCO4A1_uc002yde.1_5'Flank	NM_016354	NP_057438			solute carrier organic anion transporter family						sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(1)	1	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;2.33e-06)															---	---	---	---
ARFGAP1	55738	broad.mit.edu	37	20	61906824	61906825	+	Intron	INS	-	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:61906824_61906825insC	uc002yem.2	+						ARFGAP1_uc011aas.1_Intron|ARFGAP1_uc011aat.1_Intron|ARFGAP1_uc002yel.2_Intron|ARFGAP1_uc002yen.2_Intron	NM_018209	NP_060679			ADP-ribosylation factor GTPase activating						COPI coating of Golgi vesicle|protein transport|regulation of ARF GTPase activity|retrograde vesicle-mediated transport, Golgi to ER	cytosol|Golgi-associated vesicle membrane	ARF GTPase activator activity|zinc ion binding			pancreas(1)	1	all_cancers(38;1.59e-09)																	---	---	---	---
ARFRP1	10139	broad.mit.edu	37	20	62333351	62333355	+	Intron	DEL	CCCCC	-	-	rs66479347		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:62333351_62333355delCCCCC	uc002yga.2	-						ARFRP1_uc002ygc.2_Intron|ARFRP1_uc002ygh.3_Intron|ARFRP1_uc011abf.1_Intron|ARFRP1_uc011abg.1_Intron|ARFRP1_uc002yge.2_Intron|ARFRP1_uc002ygd.2_Intron|ARFRP1_uc002ygf.2_Intron|ARFRP1_uc002ygg.2_Intron|ARFRP1_uc011abh.1_Intron	NM_003224	NP_003215			ADP-ribosylation factor related protein 1						small GTPase mediated signal transduction	Golgi apparatus|membrane fraction	GTP binding|GTPase activity			breast(1)|skin(1)	2	all_cancers(38;9.53e-13)|all_epithelial(29;2.64e-14)|Lung NSC(23;7e-10)|all_lung(23;2.53e-09)		Epithelial(9;4.09e-08)|all cancers(9;1.7e-07)|OV - Ovarian serous cystadenocarcinoma(5;0.0102)															---	---	---	---
PRPF6	24148	broad.mit.edu	37	20	62663047	62663048	+	Intron	DEL	AC	-	-	rs28680252	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:62663047_62663048delAC	uc002yho.2	+						PRPF6_uc002yhp.2_Intron|NCRNA00176_uc002yhq.2_5'Flank|NCRNA00176_uc011abq.1_5'Flank	NM_012469	NP_036601			PRP6 pre-mRNA processing factor 6 homolog						assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			ovary(2)	2	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)																	---	---	---	---
MYT1	4661	broad.mit.edu	37	20	62836762	62836762	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:62836762delT	uc002yii.2	+						MYT1_uc002yih.2_Intron|MYT1_uc002yij.2_5'Flank	NM_004535	NP_004526			myelin transcription factor 1						cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)																	---	---	---	---
USP25	29761	broad.mit.edu	37	21	17203605	17203605	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:17203605delA	uc002yjy.1	+						USP25_uc011aby.1_Intron|USP25_uc002yjz.1_Intron|USP25_uc010gla.1_Intron	NM_013396	NP_037528			ubiquitin specific peptidase 25						protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)|liver(2)	5				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)														---	---	---	---
USP25	29761	broad.mit.edu	37	21	17250089	17250089	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:17250089delT	uc002yjy.1	+						USP25_uc011aby.1_Intron|USP25_uc002yjz.1_Intron|USP25_uc010gla.1_Intron	NM_013396	NP_037528			ubiquitin specific peptidase 25						protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)|liver(2)	5				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)														---	---	---	---
TMPRSS15	5651	broad.mit.edu	37	21	19701699	19701699	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:19701699delA	uc002ykw.2	-							NM_002772	NP_002763			enterokinase precursor						proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8																		---	---	---	---
Unknown	0	broad.mit.edu	37	21	21112410	21112412	+	IGR	DEL	AGA	-	-	rs1829338	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:21112410_21112412delAGA								None (None upstream) : None (None downstream)																																			---	---	---	---
MRPL39	54148	broad.mit.edu	37	21	26976400	26976400	+	Intron	DEL	A	-	-	rs11303574		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:26976400delA	uc002ylo.2	-						MRPL39_uc002yln.2_Intron	NM_017446	NP_059142			mitochondrial ribosomal protein L39 isoform a							mitochondrial ribosome	nucleotide binding				0																		---	---	---	---
RNF160	26046	broad.mit.edu	37	21	30332708	30332708	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:30332708delA	uc002ymr.2	-							NM_015565	NP_056380			zinc finger protein 294								ligase activity|zinc ion binding				0																		---	---	---	---
USP16	10600	broad.mit.edu	37	21	30409901	30409907	+	Intron	DEL	TTTTTTT	-	-	rs68075573		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:30409901_30409907delTTTTTTT	uc002ymy.2	+						USP16_uc002ymx.2_Intron|USP16_uc002ymw.2_Intron|USP16_uc011acm.1_Intron|USP16_uc011acn.1_Intron|USP16_uc011aco.1_5'Flank	NM_006447	NP_006438			ubiquitin specific protease 16 isoform a						cell division|histone deubiquitination|mitosis|positive regulation of transcription, DNA-dependent|protein homotetramerization|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|histone binding|transcription coactivator activity|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(2)|breast(1)|pancreas(1)	4																		---	---	---	---
USP16	10600	broad.mit.edu	37	21	30415629	30415629	+	Intron	DEL	A	-	-	rs2832157	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:30415629delA	uc002ymy.2	+						USP16_uc002ymx.2_Intron|USP16_uc002ymw.2_Intron|USP16_uc011acm.1_Intron|USP16_uc011acn.1_Intron|USP16_uc011aco.1_Intron	NM_006447	NP_006438			ubiquitin specific protease 16 isoform a						cell division|histone deubiquitination|mitosis|positive regulation of transcription, DNA-dependent|protein homotetramerization|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|histone binding|transcription coactivator activity|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(2)|breast(1)|pancreas(1)	4																		---	---	---	---
SFRS15	57466	broad.mit.edu	37	21	33074822	33074822	+	Intron	DEL	A	-	-	rs72441176		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:33074822delA	uc002ypd.2	-						SFRS15_uc002ype.2_Intron|SFRS15_uc010glu.2_Intron|SFRS15_uc002ypf.1_5'Flank|SFRS15_uc002ypg.2_Intron	NM_020706	NP_065757			splicing factor, arginine/serine-rich 15 isoform							nucleus	nucleotide binding|RNA binding				0																		---	---	---	---
GCFC1	94104	broad.mit.edu	37	21	34115632	34115632	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:34115632delA	uc002yqn.2	-						GCFC1_uc002yql.2_Intron|GCFC1_uc002yqm.2_Intron|GCFC1_uc002yqo.2_Intron|GCFC1_uc002yqp.2_Intron	NM_016631	NP_057715			GC-rich sequence DNA-binding factor candidate							cytosol|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2																		---	---	---	---
GCFC1	94104	broad.mit.edu	37	21	34116927	34116927	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:34116927delA	uc002yqn.2	-						GCFC1_uc002yql.2_Intron|GCFC1_uc002yqm.2_Intron|GCFC1_uc002yqo.2_Intron|GCFC1_uc002yqp.2_Intron	NM_016631	NP_057715			GC-rich sequence DNA-binding factor candidate							cytosol|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2																		---	---	---	---
IFNAR1	3454	broad.mit.edu	37	21	34715563	34715563	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:34715563delT	uc002yrn.2	+						IFNAR1_uc011adv.1_Intron	NM_000629	NP_000620			interferon-alpha receptor 1 precursor						JAK-STAT cascade|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	integral to plasma membrane	type I interferon receptor activity			central_nervous_system(1)|skin(1)	2					Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Interferon alfa-n3(DB00018)|Interferon alfacon-1(DB00069)|Interferon beta-1b(DB00068)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)													---	---	---	---
DONSON	29980	broad.mit.edu	37	21	34947889	34947889	+	3'UTR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:34947889delT	uc002ysi.1	-	9					SON_uc002ysd.2_Intron|SON_uc002yse.1_Intron|SON_uc002ysf.1_Intron|SON_uc002ysh.2_Intron	NM_017613	NP_060083			downstream neighbor of SON						multicellular organismal development	nucleus				ovary(1)|central_nervous_system(1)	2																		---	---	---	---
CLDN14	23562	broad.mit.edu	37	21	37858152	37858153	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:37858152_37858153delTT	uc002yvn.1	-						CLDN14_uc002yvo.1_Intron	NM_001146078	NP_001139550			claudin 14						calcium-independent cell-cell adhesion|protein complex assembly|tight junction assembly	endoplasmic reticulum|integral to membrane|tight junction	identical protein binding|structural molecule activity				0																		---	---	---	---
TTC3	7267	broad.mit.edu	37	21	38460480	38460480	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:38460480delT	uc002yvz.2	+						TTC3_uc011aee.1_Intron|TTC3_uc002ywa.2_Intron|TTC3_uc002ywb.2_Intron|TTC3_uc010gnf.2_Intron|TTC3_uc011aed.1_Intron|TTC3_uc010gne.1_Intron	NM_001001894	NP_001001894			tetratricopeptide repeat domain 3						protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)																---	---	---	---
DYRK1A	1859	broad.mit.edu	37	21	38845339	38845340	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:38845339_38845340delTT	uc002ywk.2	+						DYRK1A_uc002ywh.1_Intron|DYRK1A_uc002ywi.2_Intron|DYRK1A_uc002ywj.2_Intron|DYRK1A_uc002ywl.2_Intron|DYRK1A_uc002ywm.2_Intron	NM_001396	NP_001387			dual-specificity tyrosine-(Y)-phosphorylation						nervous system development|peptidyl-tyrosine phosphorylation|protein autophosphorylation	nuclear speck	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding|protein self-association|protein serine/threonine kinase activity			ovary(2)|lung(1)|breast(1)	4																		---	---	---	---
BRWD1	54014	broad.mit.edu	37	21	40584804	40584804	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:40584804delA	uc002yxk.1	-						BRWD1_uc010goc.1_Intron|BRWD1_uc002yxl.2_Intron|BRWD1_uc010god.1_Intron	NM_018963	NP_061836			bromodomain and WD repeat domain containing 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)																---	---	---	---
PRDM15	63977	broad.mit.edu	37	21	43291441	43291441	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:43291441delC	uc002yzq.1	-						PRDM15_uc002yzo.2_Intron|PRDM15_uc002yzp.2_Intron|PRDM15_uc002yzr.1_Intron	NM_022115	NP_071398			PR domain containing 15 isoform 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	21	43595231	43595237	+	IGR	DEL	AAAAAAG	-	-	rs141977787		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:43595231_43595237delAAAAAAG								UMODL1 (32126 upstream) : ABCG1 (24562 downstream)																																			---	---	---	---
NDUFV3	4731	broad.mit.edu	37	21	44327107	44327107	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:44327107delT	uc002zcn.2	+						NDUFV3_uc002zcm.2_Intron	NM_001001503	NP_001001503			NADH-ubiquinone oxidoreductase flavoprotein 3						mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I|nucleus	NADH dehydrogenase (ubiquinone) activity			ovary(2)	2				STAD - Stomach adenocarcinoma(101;0.0606)	NADH(DB00157)													---	---	---	---
CBS	875	broad.mit.edu	37	21	44474240	44474240	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:44474240delT	uc002zcu.2	-						CBS_uc002zcs.1_Intron|CBS_uc002zct.2_Intron|CBS_uc002zcw.3_Intron|CBS_uc002zcv.2_Intron	NM_000071	NP_000062			cystathionine-beta-synthase						cysteine biosynthetic process from serine|cysteine biosynthetic process via cystathionine|homocysteine catabolic process|hydrogen sulfide biosynthetic process|L-cysteine catabolic process|L-serine catabolic process	cytosol|nucleolus	cystathionine beta-synthase activity|heme binding|protein homodimerization activity|pyridoxal phosphate binding|ubiquitin protein ligase binding				0					L-Cysteine(DB00151)|L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)|S-Adenosylmethionine(DB00118)													---	---	---	---
CBS	875	broad.mit.edu	37	21	44476001	44476002	+	Intron	DEL	TT	-	-	rs79861734		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:44476001_44476002delTT	uc002zcu.2	-						CBS_uc002zcs.1_Intron|CBS_uc002zct.2_Intron|CBS_uc002zcw.3_Intron|CBS_uc002zcv.2_Intron|CBS_uc002zcx.2_3'UTR	NM_000071	NP_000062			cystathionine-beta-synthase						cysteine biosynthetic process from serine|cysteine biosynthetic process via cystathionine|homocysteine catabolic process|hydrogen sulfide biosynthetic process|L-cysteine catabolic process|L-serine catabolic process	cytosol|nucleolus	cystathionine beta-synthase activity|heme binding|protein homodimerization activity|pyridoxal phosphate binding|ubiquitin protein ligase binding				0					L-Cysteine(DB00151)|L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)|S-Adenosylmethionine(DB00118)													---	---	---	---
CBS	875	broad.mit.edu	37	21	44486330	44486330	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:44486330delC	uc002zcu.2	-						CBS_uc002zcs.1_Intron|CBS_uc002zct.2_Intron|CBS_uc002zcw.3_Intron|CBS_uc002zcv.2_Intron	NM_000071	NP_000062			cystathionine-beta-synthase						cysteine biosynthetic process from serine|cysteine biosynthetic process via cystathionine|homocysteine catabolic process|hydrogen sulfide biosynthetic process|L-cysteine catabolic process|L-serine catabolic process	cytosol|nucleolus	cystathionine beta-synthase activity|heme binding|protein homodimerization activity|pyridoxal phosphate binding|ubiquitin protein ligase binding				0					L-Cysteine(DB00151)|L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)|S-Adenosylmethionine(DB00118)													---	---	---	---
HSF2BP	11077	broad.mit.edu	37	21	44949885	44949885	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:44949885delT	uc002zdi.2	-						HSF2BP_uc011aey.1_Intron	NM_007031	NP_008962			heat shock transcription factor 2 binding						spermatogenesis|transcription from RNA polymerase II promoter	cytosol	binding			skin(1)	1				STAD - Stomach adenocarcinoma(101;0.18)														---	---	---	---
PWP2	5822	broad.mit.edu	37	21	45546769	45546769	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:45546769delT	uc002zeb.2	+							NM_005049	NP_005040			PWP2 periodic tryptophan protein homolog							cytoplasm|nucleolus	signal transducer activity			pancreas(1)	1				STAD - Stomach adenocarcinoma(101;0.172)|Colorectal(79;0.2)														---	---	---	---
DNMT3L	29947	broad.mit.edu	37	21	45666330	45666330	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:45666330delG	uc002zeg.1	-	12	1595	c.1111delC	c.(1111-1113)CTAfs	p.L371fs	DNMT3L_uc002zeh.1_Frame_Shift_Del_p.L372fs	NM_175867	NP_787063	Q9UJW3	DNM3L_HUMAN	cytosine-5-methyltransferase 3-like protein	371					DNA methylation|negative regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|spermatogenesis	cytosol	enzyme activator activity|enzyme binding|metal ion binding			skin(2)	2				Colorectal(79;0.0165)|READ - Rectum adenocarcinoma(84;0.0781)														---	---	---	---
KRTAP10-1	386677	broad.mit.edu	37	21	45959500	45959500	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:45959500delG	uc002zfh.1	-	1	579	c.534delC	c.(532-534)CCCfs	p.P178fs	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198691	NP_941964	P60331	KR101_HUMAN	keratin associated protein 10-1	178	24 X 5 AA repeats of C-C-X(3).					keratin filament				skin(1)	1																		---	---	---	---
MCM3AP	8888	broad.mit.edu	37	21	47678651	47678652	+	Intron	INS	-	TG	TG	rs138647437	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:47678651_47678652insTG	uc002zir.1	-						MCM3AP_uc002zip.1_Intron|MCM3AP_uc002ziq.1_Intron	NM_003906	NP_003897			minichromosome maintenance complex component 3						DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			large_intestine(2)|lung(1)|ovary(1)|skin(1)	5	Breast(49;0.112)																	---	---	---	---
DIP2A	23181	broad.mit.edu	37	21	47965735	47965735	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:47965735delT	uc002zjo.2	+						DIP2A_uc011afy.1_Intron|DIP2A_uc011afz.1_Intron|DIP2A_uc002zjl.2_Intron|DIP2A_uc002zjm.2_Intron|DIP2A_uc010gql.2_Intron|DIP2A_uc002zjn.2_Intron|DIP2A_uc002zjq.2_Intron	NM_015151	NP_055966			disco-interacting protein 2A isoform a						multicellular organismal development	nucleus	catalytic activity|transcription factor binding			ovary(2)	2	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)														---	---	---	---
CCT8L2	150160	broad.mit.edu	37	22	17071787	17071787	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:17071787delT	uc002zlp.1	-	1	1914	c.1654delA	c.(1654-1656)ATCfs	p.I552fs		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	552					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)																---	---	---	---
Unknown	0	broad.mit.edu	37	22	17336954	17336954	+	IGR	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:17336954delG								HSFYL1 (26729 upstream) : GAB4 (105875 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	22	17341117	17341117	+	IGR	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:17341117delG								HSFYL1 (30892 upstream) : GAB4 (101712 downstream)																																			---	---	---	---
IL17RA	23765	broad.mit.edu	37	22	17581032	17581037	+	Intron	DEL	AAAAAA	-	-	rs72374041		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:17581032_17581037delAAAAAA	uc002zly.2	+						IL17RA_uc010gqt.2_Intron	NM_014339	NP_055154			interleukin 17A receptor precursor						fibroblast activation|positive regulation of interleukin-23 production	integral to plasma membrane	interleukin-17 receptor activity			skin(2)	2		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.241)														---	---	---	---
SLC25A1	6576	broad.mit.edu	37	22	19164530	19164530	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:19164530delG	uc002zoz.2	-						SLC25A1_uc002zoy.2_Intron|SLC25A1_uc002zpa.2_Intron	NM_005984	NP_005975			solute carrier family 25 (mitochondrial carrier;						gluconeogenesis|long-chain fatty-acyl-CoA biosynthetic process|mitochondrial citrate transport|triglyceride biosynthetic process	integral to membrane|mitochondrial inner membrane	citrate transmembrane transporter activity|protein binding				0	Colorectal(54;0.0993)	all_lung(157;9.94e-09)		Lung(27;0.124)														---	---	---	---
CLTCL1	8218	broad.mit.edu	37	22	19246388	19246388	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:19246388delA	uc002zpb.2	-						CLTCL1_uc011agv.1_Intron|CLTCL1_uc011agw.1_Intron	NM_007098	NP_009029			clathrin, heavy polypeptide-like 1 isoform 1						anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			ovary(4)|central_nervous_system(1)	5	Colorectal(54;0.0993)							T	?	ALCL								---	---	---	---
DGCR8	54487	broad.mit.edu	37	22	20093809	20093809	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:20093809delG	uc002zri.2	+						DGCR8_uc010grz.2_Intron|DGCR8_uc002zrj.2_Intron	NM_022720	NP_073557			DiGeorge syndrome critical region gene 8						primary miRNA processing	cytoplasm|cytoplasm|microtubule cytoskeleton|nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding				0	Colorectal(54;0.0993)																	---	---	---	---
Unknown	0	broad.mit.edu	37	22	20731389	20731389	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:20731389delA	uc011ahq.1	-											RecName: Full=Putative ubiquitin carboxyl-terminal hydrolase 41;          EC=3.1.2.15; AltName: Full=Ubiquitin thioesterase 41; AltName: Full=Ubiquitin-specific-processing protease 41; AltName: Full=Deubiquitinating enzyme 41;																														---	---	---	---
LOC96610	96610	broad.mit.edu	37	22	23010922	23010922	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:23010922delG	uc011aim.1	+											Parts of antibodies, mostly variable regions.												0																		---	---	---	---
RTDR1	27156	broad.mit.edu	37	22	23404190	23404191	+	Intron	INS	-	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:23404190_23404191insC	uc002zwt.2	-							NM_014433	NP_055248			rhabdoid tumor deletion region protein 1								binding			ovary(1)	1	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.175)														---	---	---	---
DDT	1652	broad.mit.edu	37	22	24271693	24271694	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:24271693_24271694delAA	uc011ajf.1	-							NM_001355	NP_001346			D-dopachrome tautomerase						melanin biosynthetic process	cytoplasm	D-dopachrome decarboxylase activity|dopachrome isomerase activity|protein binding				0																		---	---	---	---
CYTSA	23384	broad.mit.edu	37	22	24665251	24665251	+	5'Flank	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:24665251delT	uc002zzw.2	+						CYTSA_uc002zzv.3_5'Flank|CYTSA_uc011ajq.1_5'Flank	NM_015330	NP_056145			cytospin A						cell cycle|cell division						0																		---	---	---	---
HPS4	89781	broad.mit.edu	37	22	26849090	26849090	+	3'UTR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:26849090delA	uc003acl.2	-	14					HPS4_uc003aci.2_3'UTR|HPS4_uc003acj.2_3'UTR|HPS4_uc003ack.2_3'UTR|HPS4_uc003acn.2_3'UTR|HPS4_uc003ach.2_3'UTR	NM_022081	NP_071364			light ear protein isoform a						lysosome organization|positive regulation of eye pigmentation|protein stabilization|protein targeting	lysosome|melanosome|membrane fraction|platelet dense granule	protein homodimerization activity				0														Hermansky-Pudlak_syndrome				---	---	---	---
EMID1	129080	broad.mit.edu	37	22	29654727	29654727	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:29654727delC	uc003aen.2	+						EMID1_uc003aem.2_Intron|EMID1_uc003aeo.2_Intron|EMID1_uc003aep.2_Intron	NM_133455	NP_597712			EMI domain containing 1							collagen					0																		---	---	---	---
MTMR3	8897	broad.mit.edu	37	22	30409662	30409662	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:30409662delT	uc003agv.3	+						MTMR3_uc003agu.3_Intron|MTMR3_uc003agw.3_Intron	NM_021090	NP_066576			myotubularin-related protein 3 isoform c						phosphatidylinositol dephosphorylation	cytoplasm|membrane|membrane fraction|nucleus	metal ion binding|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(3)|ovary(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(5;0.00204)|Epithelial(10;0.06)|all cancers(5;0.107)															---	---	---	---
RNF215	200312	broad.mit.edu	37	22	30775966	30775968	+	Intron	DEL	TGG	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:30775966_30775968delTGG	uc003ahp.2	-						RNF215_uc011akw.1_Intron	NM_001017981	NP_001017981			ring finger protein 215							integral to membrane	zinc ion binding			central_nervous_system(1)	1																		---	---	---	---
SYN3	8224	broad.mit.edu	37	22	33230144	33230144	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:33230144delT	uc003amx.2	-						SYN3_uc003amy.2_Intron|SYN3_uc003amz.2_Intron|TIMP3_uc003anb.2_Intron	NM_003490	NP_003481			synapsin III isoform IIIa						neurotransmitter secretion	cell junction|synaptic vesicle membrane	ATP binding|ligase activity			skin(1)	1																		---	---	---	---
TIMP3	7078	broad.mit.edu	37	22	33255324	33255324	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:33255324delC	uc003anb.2	+	5	1782	c.596delC	c.(595-597)GCCfs	p.A199fs	SYN3_uc003amx.2_Intron|SYN3_uc003amy.2_Intron|SYN3_uc003amz.2_Intron	NM_000362	NP_000353	P35625	TIMP3_HUMAN	tissue inhibitor of metalloproteinase 3	199					negative regulation of membrane protein ectodomain proteolysis|visual perception		metal ion binding|metalloendopeptidase inhibitor activity|protein binding			lung(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	22	35560569	35560570	+	IGR	INS	-	TTGTTG	TTGTTG	rs147993226	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:35560569_35560570insTTGTTG								ISX (77191 upstream) : HMGXB4 (92875 downstream)																																			---	---	---	---
KCTD17	79734	broad.mit.edu	37	22	37458553	37458553	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:37458553delT	uc010gxb.2	+						KCTD17_uc011amv.1_Intron|KCTD17_uc010gxc.2_Intron	NM_024681	NP_078957			potassium channel tetramerisation domain							voltage-gated potassium channel complex	identical protein binding|voltage-gated potassium channel activity				0																		---	---	---	---
SH3BP1	23616	broad.mit.edu	37	22	38039084	38039084	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:38039084delC	uc003ati.2	+						SH3BP1_uc003atg.1_Intron|SH3BP1_uc011anl.1_Intron|SH3BP1_uc003ath.1_Intron|SH3BP1_uc003atj.1_Intron|SH3BP1_uc003atk.1_Intron|uc003atl.1_Intron	NM_018957	NP_061830			SH3-domain binding protein 1						signal transduction	cytoplasm	GTPase activator activity|SH3 domain binding			central_nervous_system(1)	1	Melanoma(58;0.0574)															OREG0026546	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
BAIAP2L2	80115	broad.mit.edu	37	22	38503898	38503899	+	Frame_Shift_Del	DEL	AG	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:38503898_38503899delAG	uc003auw.2	-	4	380_381	c.236_237delCT	c.(235-237)TCTfs	p.S79fs		NM_025045	NP_079321	Q6UXY1	BI2L2_HUMAN	BAI1-associated protein 2-like 2	79	IMD.				filopodium assembly|signal transduction		cytoskeletal adaptor activity|SH3 domain binding			pancreas(1)	1	Melanoma(58;0.045)																	---	---	---	---
DMC1	11144	broad.mit.edu	37	22	38934201	38934201	+	Intron	DEL	A	-	-	rs66487664		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:38934201delA	uc003avz.1	-						DMC1_uc011anv.1_Intron	NM_007068	NP_008999			DMC1 dosage suppressor of mck1 homolog						reciprocal meiotic recombination	condensed nuclear chromosome	ATP binding|DNA binding|DNA-dependent ATPase activity|protein binding			ovary(1)	1	Melanoma(58;0.0286)												Homologous_recombination					---	---	---	---
DMC1	11144	broad.mit.edu	37	22	38964457	38964458	+	Intron	DEL	TG	-	-	rs11570378		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:38964457_38964458delTG	uc003avz.1	-						DMC1_uc011anv.1_5'Flank|DMC1_uc003awa.1_Intron	NM_007068	NP_008999			DMC1 dosage suppressor of mck1 homolog						reciprocal meiotic recombination	condensed nuclear chromosome	ATP binding|DNA binding|DNA-dependent ATPase activity|protein binding			ovary(1)	1	Melanoma(58;0.0286)												Homologous_recombination					---	---	---	---
CACNA1I	8911	broad.mit.edu	37	22	40061872	40061872	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:40061872delC	uc003ayc.2	+						CACNA1I_uc003ayd.2_Intron|CACNA1I_uc003aye.2_Intron|CACNA1I_uc003ayf.2_Intron	NM_021096	NP_066919			calcium channel, voltage-dependent, T type,						axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)													---	---	---	---
EP300	2033	broad.mit.edu	37	22	41545781	41545782	+	Frame_Shift_Ins	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:41545781_41545782insT	uc003azl.3	+	14	2791_2792	c.2396_2397insT	c.(2395-2397)TCTfs	p.S799fs		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	799	Poly-Ser.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64								T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				---	---	---	---
EP300	2033	broad.mit.edu	37	22	41565470	41565470	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:41565470delT	uc003azl.3	+							NM_001429	NP_001420			E1A binding protein p300						apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64								T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				---	---	---	---
ACO2	50	broad.mit.edu	37	22	41921495	41921496	+	Intron	DEL	AG	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:41921495_41921496delAG	uc003bac.2	+						ACO2_uc003bad.2_Intron	NM_001098	NP_001089			aconitase 2, mitochondrial precursor						citrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron ion binding|isocitrate hydro-lyase (cis-aconitate-forming) activity			breast(2)|ovary(1)|lung(1)	4																		---	---	---	---
RRP7B	91695	broad.mit.edu	37	22	42972105	42972107	+	RNA	DEL	CCT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:42972105_42972107delCCT	uc003bcs.2	-	6		c.587_589delAGG			RRP7B_uc003bct.2_RNA					Homo sapiens cDNA FLJ90011 fis, clone HEMBA1000443, highly similar to Gastric cancer antigen Zg14.												0																		---	---	---	---
ARFGAP3	26286	broad.mit.edu	37	22	43213405	43213405	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:43213405delT	uc003bdd.2	-						ARFGAP3_uc010gzf.2_Intron|ARFGAP3_uc011apu.1_Intron	NM_014570	NP_055385			ADP-ribosylation factor GTPase activating						intracellular protein transport|protein secretion|regulation of ARF GTPase activity|vesicle-mediated transport	cytosol|Golgi membrane	ARF GTPase activator activity|protein transporter activity|zinc ion binding			breast(1)	1																		---	---	---	---
ARFGAP3	26286	broad.mit.edu	37	22	43227796	43227796	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:43227796delT	uc003bdd.2	-						ARFGAP3_uc010gzf.2_Intron|ARFGAP3_uc011apu.1_Intron	NM_014570	NP_055385			ADP-ribosylation factor GTPase activating						intracellular protein transport|protein secretion|regulation of ARF GTPase activity|vesicle-mediated transport	cytosol|Golgi membrane	ARF GTPase activator activity|protein transporter activity|zinc ion binding			breast(1)	1																		---	---	---	---
PACSIN2	11252	broad.mit.edu	37	22	43287235	43287235	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:43287235delG	uc010gzg.2	-						PACSIN2_uc003bdg.3_Intron|PACSIN2_uc003bde.3_Intron|PACSIN2_uc003bdf.3_Intron	NM_007229	NP_009160			protein kinase C and casein kinase substrate in						actin cytoskeleton organization|endocytosis	cytoplasmic membrane-bounded vesicle	transporter activity				0		Glioma(61;0.222)																---	---	---	---
TTLL1	25809	broad.mit.edu	37	22	43442684	43442684	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:43442684delT	uc003bdi.2	-						TTLL1_uc010gzh.2_Intron|TTLL1_uc003bdj.2_Intron|TTLL1_uc003bdh.2_Intron	NM_012263	NP_036395			tubulin tyrosine ligase-like family, member 1						protein polyglutamylation	cytoplasm|microtubule	ATP binding|tubulin-glutamic acid ligase activity|tubulin-tyrosine ligase activity			skin(1)	1		Ovarian(80;0.0694)		BRCA - Breast invasive adenocarcinoma(115;0.00461)														---	---	---	---
SMC1B	27127	broad.mit.edu	37	22	45754477	45754477	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:45754477delA	uc003bgc.2	-						SMC1B_uc003bgd.2_Intron	NM_148674	NP_683515			SMC1 structural maintenance of chromosomes						chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			ovary(2)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)														---	---	---	---
GRAMD4	23151	broad.mit.edu	37	22	47070686	47070686	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:47070686delG	uc003bhx.2	+						GRAMD4_uc010had.2_Intron|GRAMD4_uc003bhy.2_Intron	NM_015124	NP_055939			death-inducing-protein						apoptosis	integral to membrane|mitochondrial membrane				ovary(1)	1		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|BRCA - Breast invasive adenocarcinoma(115;0.166)														---	---	---	---
TBC1D22A	25771	broad.mit.edu	37	22	47188443	47188444	+	Frame_Shift_Ins	INS	-	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:47188443_47188444insC	uc003bib.2	+	2	224_225	c.89_90insC	c.(88-90)CACfs	p.H30fs	TBC1D22A_uc010haf.2_5'UTR|TBC1D22A_uc003bic.2_Frame_Shift_Ins_p.H30fs|TBC1D22A_uc003bie.2_Intron|TBC1D22A_uc003bid.2_RNA|TBC1D22A_uc010hag.2_RNA|TBC1D22A_uc003bif.2_5'UTR	NM_014346	NP_055161	Q8WUA7	TB22A_HUMAN	TBC1 domain family, member 22A	30						intracellular	protein homodimerization activity|Rab GTPase activator activity			ovary(1)	1		all_cancers(38;4.44e-05)|all_epithelial(38;0.000507)|Breast(42;0.0488)|all_lung(38;0.0682)|Ovarian(80;0.0731)|all_neural(38;0.0966)|Glioma(61;0.222)|Lung SC(80;0.236)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0347)|BRCA - Breast invasive adenocarcinoma(115;0.231)														---	---	---	---
ZBED4	9889	broad.mit.edu	37	22	50280682	50280682	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:50280682delC	uc003bix.2	+	2	3842	c.3372delC	c.(3370-3372)TGCfs	p.C1124fs		NM_014838	NP_055653	O75132	ZBED4_HUMAN	zinc finger, BED-type containing 4	1124						cytoplasm|nucleus	DNA binding|metal ion binding|protein dimerization activity			ovary(2)	2		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)|BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)														---	---	---	---
IL17REL	400935	broad.mit.edu	37	22	50437528	50437529	+	Intron	DEL	CA	-	-	rs71919421		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:50437528_50437529delCA	uc003bje.1	-							NM_001001694	NP_001001694			interleukin 17 receptor E-like											pancreas(1)	1		all_cancers(38;5.53e-07)|all_epithelial(38;3.84e-06)|all_lung(38;0.00208)|Breast(42;0.0104)|Lung NSC(38;0.0199)|Ovarian(80;0.0907)|Lung SC(80;0.236)		BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)														---	---	---	---
ARSA	410	broad.mit.edu	37	22	51063978	51063978	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:51063978delG	uc003bnb.3	-						ARSA_uc003bna.3_Intron|ARSA_uc003bnc.3_Intron|ARSA_uc003bnd.3_Intron|ARSA_uc003bmz.3_Intron	NM_001085426	NP_001078895			arylsulfatase A isoform a precursor							lysosome	arylsulfatase activity|calcium ion binding|cerebroside-sulfatase activity			pancreas(1)|skin(1)	2		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)	Micafungin(DB01141)													---	---	---	---
EGFL6	25975	broad.mit.edu	37	X	13651258	13651258	+	3'UTR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:13651258delT	uc004cvi.2	+	12					EGFL6_uc004cvj.2_3'UTR	NM_015507	NP_056322			epidermal growth factor-like protein 6						cell adhesion|cell cycle|cell differentiation|multicellular organismal development	basement membrane|extracellular space|membrane	calcium ion binding|integrin binding			breast(2)	2																		---	---	---	---
GEMIN8	54960	broad.mit.edu	37	X	14039512	14039512	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:14039512delA	uc004cwb.2	-						GEMIN8_uc004cwc.2_Intron|GEMIN8_uc004cwd.2_Intron	NM_017856	NP_060326			gem (nuclear organelle) associated protein 8						spliceosomal snRNP assembly	Cajal body|cytoplasm|SMN complex|spliceosomal complex	protein binding				0																		---	---	---	---
FANCB	2187	broad.mit.edu	37	X	14868472	14868472	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:14868472delA	uc004cwg.1	-						FANCB_uc004cwh.1_Intron	NM_001018113	NP_001018123			Fanconi anemia complementation group B						DNA repair	nucleoplasm				lung(1)	1	Hepatocellular(33;0.183)												Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				---	---	---	---
ASB9	140462	broad.mit.edu	37	X	15273107	15273107	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:15273107delA	uc004cwl.2	-						ASB9_uc004cwk.2_Intron|ASB9_uc004cwm.2_Intron|ASB9_uc010ner.2_Intron|ASB9_uc004cwn.2_Intron	NM_001031739	NP_001026909			ankyrin repeat and SOCS box-containing 9 isoform						intracellular signal transduction						0	Hepatocellular(33;0.183)																	---	---	---	---
CTPS2	56474	broad.mit.edu	37	X	16688837	16688837	+	Intron	DEL	T	-	-	rs72340997		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:16688837delT	uc004cxk.2	-						CTPS2_uc004cxl.2_Intron|CTPS2_uc004cxm.2_Intron	NM_001144002	NP_001137474			cytidine triphosphate synthase II						glutamine metabolic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine nucleotide biosynthetic process	cytosol	ATP binding|CTP synthase activity			ovary(1)	1	Hepatocellular(33;0.0997)																	---	---	---	---
RBBP7	5931	broad.mit.edu	37	X	16871713	16871713	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:16871713delA	uc004cxt.2	-						RBBP7_uc004cxs.1_Intron|RBBP7_uc004cxu.2_Intron|RBBP7_uc010nez.2_3'UTR	NM_002893	NP_002884			retinoblastoma binding protein 7						cell proliferation|cellular heat acclimation|CenH3-containing nucleosome assembly at centromere|DNA replication|multicellular organismal development|negative regulation of cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex|NuRD complex	protein binding			upper_aerodigestive_tract(1)|ovary(1)	2	Hepatocellular(33;0.0997)																	---	---	---	---
REPS2	9185	broad.mit.edu	37	X	17086437	17086437	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:17086437delA	uc004cxv.1	+						REPS2_uc004cxw.1_Intron|REPS2_uc011miw.1_Intron	NM_004726	NP_004717			RALBP1 associated Eps domain containing 2						epidermal growth factor receptor signaling pathway|protein complex assembly	cytoplasm	calcium ion binding|protein binding			skin(2)|central_nervous_system(1)	3	Hepatocellular(33;0.183)																	---	---	---	---
RAI2	10742	broad.mit.edu	37	X	17819461	17819461	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:17819461delG	uc004cyf.2	-	3	1240	c.670delC	c.(670-672)CTGfs	p.L224fs	RAI2_uc004cyg.2_Frame_Shift_Del_p.L224fs|RAI2_uc010nfa.2_Frame_Shift_Del_p.L224fs|RAI2_uc004cyh.3_Frame_Shift_Del_p.L224fs|RAI2_uc011miy.1_Frame_Shift_Del_p.L174fs	NM_021785	NP_068557	Q9Y5P3	RAI2_HUMAN	retinoic acid induced 2	224	Pro-rich.				embryo development					ovary(1)|breast(1)	2	Hepatocellular(33;0.183)																	---	---	---	---
SCML2	10389	broad.mit.edu	37	X	18275212	18275212	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:18275212delA	uc004cyl.2	-						SCML2_uc004cyk.3_Intron|SCML2_uc010nfd.1_Intron|SCML2_uc011miz.1_Intron|SCML2_uc010nfc.2_Intron	NM_006089	NP_006080			sex comb on midleg-like 2						anatomical structure morphogenesis	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(33;0.183)																	---	---	---	---
SCML2	10389	broad.mit.edu	37	X	18278429	18278429	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:18278429delA	uc004cyl.2	-						SCML2_uc004cyk.3_Intron|SCML2_uc010nfd.1_Intron|SCML2_uc011miz.1_Intron|SCML2_uc010nfc.2_Intron	NM_006089	NP_006080			sex comb on midleg-like 2						anatomical structure morphogenesis	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(33;0.183)																	---	---	---	---
SCML2	10389	broad.mit.edu	37	X	18343207	18343209	+	Intron	DEL	AAA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:18343207_18343209delAAA	uc004cyl.2	-						SCML2_uc004cyk.3_Intron|SCML2_uc010nfd.1_Intron|SCML2_uc011miz.1_Intron	NM_006089	NP_006080			sex comb on midleg-like 2						anatomical structure morphogenesis	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(33;0.183)																	---	---	---	---
PPEF1	5475	broad.mit.edu	37	X	18748213	18748213	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:18748213delT	uc004cyq.2	+						PPEF1_uc004cyp.2_Intron|PPEF1_uc004cyr.2_Intron|PPEF1_uc004cys.2_Intron|PPEF1_uc011mja.1_Intron|PPEF1_uc011mjb.1_5'Flank	NM_006240	NP_006231			protein phosphatase with EF hand calcium-binding						detection of stimulus involved in sensory perception|protein dephosphorylation		calcium ion binding|iron ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity				0	Hepatocellular(33;0.183)																	---	---	---	---
PPEF1	5475	broad.mit.edu	37	X	18824431	18824432	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:18824431_18824432insT	uc004cyq.2	+						PPEF1_uc004cyp.2_Intron|PPEF1_uc004cyr.2_Intron|PPEF1_uc004cys.2_Intron|PPEF1_uc011mja.1_Intron|PPEF1_uc011mjb.1_Intron	NM_006240	NP_006231			protein phosphatase with EF hand calcium-binding						detection of stimulus involved in sensory perception|protein dephosphorylation		calcium ion binding|iron ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity				0	Hepatocellular(33;0.183)																	---	---	---	---
EIF1AX	1964	broad.mit.edu	37	X	20156751	20156751	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:20156751delA	uc004czt.2	-						SCARNA9L_uc010nfp.2_5'Flank	NM_001412	NP_001403			X-linked eukaryotic translation initiation							cytosol	translation initiation factor activity			ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	X	26522467	26522468	+	IGR	INS	-	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:26522467_26522468insC								MAGEB6 (308705 upstream) : VENTXP1 (53986 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	X	27133242	27133242	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:27133242delA								VENTXP1 (554074 upstream) : SMEK3P (345086 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	X	27537028	27537028	+	IGR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:27537028delA								SMEK3P (55570 upstream) : DCAF8L2 (227898 downstream)																																			---	---	---	---
DMD	1756	broad.mit.edu	37	X	31222117	31222118	+	Frame_Shift_Ins	INS	-	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:31222117_31222118insC	uc004dda.1	-	67	10011_10012	c.9767_9768insG	c.(9766-9768)GGCfs	p.G3256fs	DMD_uc004dcq.1_Frame_Shift_Ins_p.G527fs|DMD_uc004dcr.1_Frame_Shift_Ins_p.G796fs|DMD_uc004dcs.1_Frame_Shift_Ins_p.G796fs|DMD_uc004dct.1_Frame_Shift_Ins_p.G796fs|DMD_uc004dcu.1_Frame_Shift_Ins_p.G796fs|DMD_uc004dcv.1_Frame_Shift_Ins_p.G796fs|DMD_uc004dcw.2_Frame_Shift_Ins_p.G1912fs|DMD_uc004dcx.2_Frame_Shift_Ins_p.G1915fs|DMD_uc004dcz.2_Frame_Shift_Ins_p.G3133fs|DMD_uc004dcy.1_Frame_Shift_Ins_p.G3252fs|DMD_uc004ddb.1_Frame_Shift_Ins_p.G3248fs|DMD_uc004dcm.1_Frame_Shift_Ins_p.G188fs|DMD_uc004dcn.1_Frame_Shift_Ins_p.G188fs|DMD_uc004dco.1_Frame_Shift_Ins_p.G188fs|DMD_uc004dcp.1_Frame_Shift_Ins_p.G188fs|DMD_uc011mkb.1_Frame_Shift_Ins_p.G188fs|DMD_uc010ngm.2_Frame_Shift_Ins_p.G188fs	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	3256	Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)																---	---	---	---
DMD	1756	broad.mit.edu	37	X	32456541	32456541	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:32456541delT	uc004dda.1	-						DMD_uc004dcz.2_Intron|DMD_uc004dcy.1_Intron|DMD_uc004ddb.1_Intron|DMD_uc010ngo.1_Intron	NM_004006	NP_003997			dystrophin Dp427m isoform						muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)																---	---	---	---
DMD	1756	broad.mit.edu	37	X	32613815	32613815	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:32613815delT	uc004dda.1	-						DMD_uc004dcz.2_Intron|DMD_uc004dcy.1_Intron|DMD_uc004ddb.1_Intron|DMD_uc010ngo.1_Intron|DMD_uc004ddf.2_Intron|DMD_uc010ngp.1_Intron|DMD_uc010ngq.1_Intron	NM_004006	NP_003997			dystrophin Dp427m isoform						muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)																---	---	---	---
CXorf59	286464	broad.mit.edu	37	X	36117799	36117799	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:36117799delA	uc004ddk.1	+							NM_173695	NP_775966			hypothetical protein LOC286464							integral to membrane				central_nervous_system(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	X	36229987	36229987	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:36229987delT								CXorf59 (66800 upstream) : CXorf30 (24064 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	X	36579122	36579123	+	IGR	INS	-	TTCC	TTCC			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:36579122_36579123insTTCC								CXorf30 (175689 upstream) : FAM47C (447347 downstream)																																			---	---	---	---
BCOR	54880	broad.mit.edu	37	X	39930433	39930434	+	Intron	INS	-	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:39930433_39930434insA	uc004den.3	-						BCOR_uc004dep.3_Intron|BCOR_uc004deo.3_Intron|BCOR_uc004dem.3_Intron	NM_001123385	NP_001116857			BCL-6 interacting corepressor isoform c						heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4																		---	---	---	---
USP9X	8239	broad.mit.edu	37	X	41056585	41056585	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:41056585delC	uc004dfb.2	+						USP9X_uc004dfc.2_Intron	NM_001039590	NP_001034679			ubiquitin specific protease 9, X-linked isoform						BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6																		---	---	---	---
Unknown	0	broad.mit.edu	37	X	41182355	41182355	+	IGR	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:41182355delG								USP9X (86525 upstream) : DDX3X (10296 downstream)																																			---	---	---	---
KDM6A	7403	broad.mit.edu	37	X	44938317	44938317	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:44938317delA	uc004dge.3	+						KDM6A_uc010nhk.2_Intron|KDM6A_uc011mkz.1_Intron|KDM6A_uc011mla.1_Intron|KDM6A_uc011mlb.1_Intron|KDM6A_uc011mlc.1_Intron|KDM6A_uc011mld.1_Intron	NM_021140	NP_066963			ubiquitously transcribed tetratricopeptide						histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84								D|N|F|S		renal|oesophageal SCC|MM								---	---	---	---
RBM10	8241	broad.mit.edu	37	X	47044618	47044618	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:47044618delC	uc004dhf.2	+						RBM10_uc004dhg.2_Intron|RBM10_uc004dhh.2_Intron|RBM10_uc010nhq.2_Intron|RBM10_uc004dhi.2_Intron	NM_005676	NP_005667			RNA binding motif protein 10 isoform 1						mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			ovary(1)|large_intestine(1)|prostate(1)|breast(1)|pancreas(1)	5																		---	---	---	---
ELK1	2002	broad.mit.edu	37	X	47500596	47500596	+	Intron	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:47500596delG	uc004dik.3	-						ELK1_uc010nhv.2_Intron|ELK1_uc010nhw.2_5'UTR|ELK1_uc004dil.3_Intron	NM_001114123	NP_001107595			ELK1 protein						innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	X	48305869	48305869	+	IGR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:48305869delT								SSX4 (53084 upstream) : SLC38A5 (11059 downstream)																																			---	---	---	---
RBM3	5935	broad.mit.edu	37	X	48435397	48435398	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:48435397_48435398delTT	uc004dkf.1	+						RBM3_uc004dkd.1_Intron|RBM3_uc004dkg.2_Intron	NM_006743	NP_006734			RNA binding motif protein 3						positive regulation of translation	dendrite|nucleus	nucleotide binding|RNA binding			ovary(1)	1																		---	---	---	---
GAGE12J	729396	broad.mit.edu	37	X	49199451	49199452	+	Intron	DEL	CA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:49199451_49199452delCA	uc004dnl.3	+						GAGE13_uc004dnn.3_Intron|GAGE8_uc011mne.1_Intron|GAGE8_uc011mnf.1_Intron|GAGE8_uc011mng.1_Intron|GAGE2A_uc004dnr.3_Intron|GAGE8_uc004dnq.3_Intron|GAGE10_uc010nis.2_Intron|GAGE12J_uc004dnk.3_Intron|GAGE2D_uc004dnp.3_Intron|GAGE2C_uc004dno.3_Intron|GAGE2E_uc010njb.2_Intron|GAGE8_uc011mnh.1_Intron	NM_001098406	NP_001465			G antigen 12J												0	Ovarian(276;0.236)																	---	---	---	---
Unknown	0	broad.mit.edu	37	X	49920893	49920893	+	IGR	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:49920893delC								CLCN5 (57001 upstream) : AKAP4 (34518 downstream)																																			---	---	---	---
SSX8	280659	broad.mit.edu	37	X	52654537	52654538	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:52654537_52654538delTT	uc011moa.1	+						SSX8_uc011mob.1_Intron					Homo sapiens cDNA FLJ56587 complete cds, highly similar to Protein SSX8.												0																		---	---	---	---
FAM104B	90736	broad.mit.edu	37	X	55172448	55172449	+	Intron	INS	-	T	T	rs5902536		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:55172448_55172449insT	uc004duh.1	-						FAM104B_uc004dug.1_Intron|FAM104B_uc004dui.3_3'UTR	NM_138362	NP_612371			hypothetical protein LOC90736												0																		---	---	---	---
LAS1L	81887	broad.mit.edu	37	X	64751477	64751477	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:64751477delA	uc004dwa.1	-						LAS1L_uc004dwc.1_Intron|LAS1L_uc004dwd.1_Intron	NM_031206	NP_112483			LAS1-like							MLL1 complex|nucleolus	protein binding			ovary(3)|large_intestine(1)	4																		---	---	---	---
MSN	4478	broad.mit.edu	37	X	64952934	64952936	+	Intron	DEL	AAG	-	-	rs113973416		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:64952934_64952936delAAG	uc004dwf.2	+							NM_002444	NP_002435			moesin						leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking	apical plasma membrane|cytoskeleton|extrinsic to membrane|microvillus membrane|nucleolus	cell adhesion molecule binding|receptor binding|structural constituent of cytoskeleton		MSN/ALK(6)	haematopoietic_and_lymphoid_tissue(6)|ovary(3)|lung(1)	10								T	ALK	ALCL								---	---	---	---
TAF1	6872	broad.mit.edu	37	X	70643256	70643257	+	Intron	DEL	TT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:70643256_70643257delTT	uc004dzu.3	+						BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Intron|TAF1_uc004dzv.3_Intron|TAF1_uc010nld.1_Intron|TAF1_uc010nle.1_Intron|TAF1_uc010nlf.1_Intron|TAF1_uc004dzx.2_Intron|TAF1_uc004dzy.2_Intron|TAF1_uc004dzw.1_Intron	NM_138923	NP_620278			TBP-associated factor 1 isoform 2						G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)																---	---	---	---
XIST	7503	broad.mit.edu	37	X	73050846	73050846	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:73050846delA	uc004ebm.1	-							NR_001564				Homo sapiens cDNA: FLJ21545 fis, clone COL06195.												0																		---	---	---	---
RLIM	51132	broad.mit.edu	37	X	73836528	73836528	+	5'Flank	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:73836528delT	uc004ebu.2	-						RLIM_uc004ebw.2_5'Flank	NM_183353	NP_899196			ring finger protein, LIM domain interacting						random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2																		---	---	---	---
ATRX	546	broad.mit.edu	37	X	76763680	76763680	+	3'UTR	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:76763680delA	uc004ecp.3	-	35					ATRX_uc004ecq.3_3'UTR|ATRX_uc004eco.3_3'UTR	NM_000489	NP_000480			transcriptional regulator ATRX isoform 1						DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						---	---	---	---
ATRX	546	broad.mit.edu	37	X	76776810	76776811	+	Intron	INS	-	A	A	rs45507999		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:76776810_76776811insA	uc004ecp.3	-						ATRX_uc004ecq.3_Intron|ATRX_uc004eco.3_Intron	NM_000489	NP_000480			transcriptional regulator ATRX isoform 1						DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						---	---	---	---
ATP7A	538	broad.mit.edu	37	X	77264922	77264922	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:77264922delT	uc004ecx.3	+						ATP7A_uc004ecw.2_3'UTR	NM_000052	NP_000043			ATPase, Cu++ transporting, alpha polypeptide						ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity				0																		---	---	---	---
CYSLTR1	10800	broad.mit.edu	37	X	77529282	77529282	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:77529282delA	uc004edb.2	-						CYSLTR1_uc010nma.2_Intron|CYSLTR1_uc010nmb.2_Intron	NM_006639	NP_006630			cysteinyl leukotriene receptor 1						elevation of cytosolic calcium ion concentration|respiratory gaseous exchange	integral to plasma membrane|membrane fraction	leukotriene receptor activity			ovary(1)	1					Amlexanox(DB01025)|Cinalukast(DB00587)|Montelukast(DB00471)|Nedocromil(DB00716)|Pranlukast(DB01411)|Zafirlukast(DB00549)													---	---	---	---
BRWD3	254065	broad.mit.edu	37	X	80047491	80047491	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:80047491delT	uc004edt.2	-						BRWD3_uc004edo.2_Intron|BRWD3_uc004edp.2_Intron|BRWD3_uc004edq.2_Intron|BRWD3_uc010nmj.1_Intron|BRWD3_uc004edr.2_Intron|BRWD3_uc004eds.2_Intron|BRWD3_uc004edu.2_Intron|BRWD3_uc004edv.2_Intron|BRWD3_uc004edw.2_Intron|BRWD3_uc004edx.2_Intron|BRWD3_uc004edy.2_Intron|BRWD3_uc004edz.2_Intron|BRWD3_uc004eea.2_Intron|BRWD3_uc004eeb.2_Intron	NM_153252	NP_694984			bromodomain and WD repeat domain containing 3											ovary(4)	4																		---	---	---	---
APOOL	139322	broad.mit.edu	37	X	84309335	84309335	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:84309335delT	uc004eem.2	+						APOOL_uc010nmp.2_Intron	NM_198450	NP_940852			apolipoprotein O-like precursor							extracellular region					0																		---	---	---	---
PCDH19	57526	broad.mit.edu	37	X	99662505	99662505	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:99662505delG	uc010nmz.2	-	1	2767	c.1091delC	c.(1090-1092)CCGfs	p.P364fs	PCDH19_uc004efw.3_Frame_Shift_Del_p.P364fs|PCDH19_uc004efx.3_Frame_Shift_Del_p.P364fs	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	364	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7																		---	---	---	---
BTK	695	broad.mit.edu	37	X	100615498	100615498	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:100615498delT	uc004ehg.2	-						BTK_uc004ehf.2_5'Flank|BTK_uc010nnh.2_5'Flank|BTK_uc010nni.2_5'Flank|BTK_uc004ehe.2_5'Flank|BTK_uc010nnj.2_5'Flank|BTK_uc010nnk.2_5'Flank|BTK_uc010nnl.2_5'Flank|BTK_uc010nnm.2_5'Flank|BTK_uc010nnn.2_Intron|BTK_uc010nno.2_Intron|BTK_uc004ehh.1_5'Flank|BTK_uc004ehi.2_Intron	NM_000061	NP_000052			Bruton agammaglobulinemia tyrosine kinase						calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding			lung(3)|central_nervous_system(2)|ovary(1)	6														Agammaglobulinemia_X-linked				---	---	---	---
TBC1D8B	54885	broad.mit.edu	37	X	106066802	106066802	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:106066802delT	uc004emo.2	+						MORC4_uc004emp.3_Intron|TBC1D8B_uc004emm.2_Intron|TBC1D8B_uc004emn.2_Intron	NM_017752	NP_060222			TBC1 domain family, member 8B (with GRAM domain)							intracellular	calcium ion binding|Rab GTPase activator activity			ovary(2)|central_nervous_system(1)|skin(1)	4																		---	---	---	---
CXorf41	139212	broad.mit.edu	37	X	106461964	106461965	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:106461964_106461965delAA	uc004enc.2	+						CXorf41_uc004end.2_Intron	NM_173494	NP_775765			hypothetical protein LOC139212												0																		---	---	---	---
COL4A6	1288	broad.mit.edu	37	X	107438186	107438187	+	Intron	DEL	AA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:107438186_107438187delAA	uc004enw.3	-						COL4A6_uc004env.3_Intron|COL4A6_uc011msn.1_Intron|COL4A6_uc010npk.2_Intron	NM_001847	NP_001838			type IV alpha 6 collagen isoform A precursor						cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(6)|urinary_tract(1)|large_intestine(1)	8														Alport_syndrome_with_Diffuse_Leiomyomatosis				---	---	---	---
ALG13	79868	broad.mit.edu	37	X	110971388	110971389	+	Intron	DEL	GT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:110971388_110971389delGT	uc011msy.1	+						ALG13_uc011msx.1_Intron|ALG13_uc011msz.1_Intron|ALG13_uc011mta.1_Intron|ALG13_uc011mtb.1_Intron					SubName: Full=Asparagine-linked glycosylation 13 homolog (S. cerevisiae);						dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			lung(1)	1																		---	---	---	---
PLS3	5358	broad.mit.edu	37	X	114868272	114868272	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:114868272delT	uc004eqd.2	+						PLS3_uc010nqg.2_Intron|PLS3_uc011mtf.1_Intron|PLS3_uc004eqe.2_Intron|PLS3_uc011mtg.1_Intron|PLS3_uc011mth.1_Intron	NM_005032	NP_005023			plastin 3							cytoplasm	actin binding|calcium ion binding			lung(1)|breast(1)	2																		---	---	---	---
IL13RA1	3597	broad.mit.edu	37	X	117907665	117907665	+	Intron	DEL	T	-	-	rs3838204		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:117907665delT	uc004eqs.2	+						IL13RA1_uc004eqt.1_Intron	NM_001560	NP_001551			interleukin 13 receptor, alpha 1 precursor							interleukin-13 receptor complex	cytokine receptor activity				0																		---	---	---	---
LAMP2	3920	broad.mit.edu	37	X	119580473	119580473	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:119580473delA	uc004est.3	-						LAMP2_uc004ess.3_Intron|LAMP2_uc011mtz.1_Intron|LAMP2_uc011mua.1_Intron|LAMP2_uc010nqp.1_Intron	NM_002294	NP_002285			lysosomal-associated membrane protein 2 isoform						platelet activation|platelet degranulation	endosome membrane|integral to membrane|late endosome|lysosomal membrane|membrane fraction|plasma membrane|platelet dense granule membrane				ovary(1)	1																		---	---	---	---
STAG2	10735	broad.mit.edu	37	X	123179073	123179073	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:123179073delT	uc004etz.3	+	7	861	c.522delT	c.(520-522)AGTfs	p.S174fs	STAG2_uc004eua.2_Frame_Shift_Del_p.S174fs|STAG2_uc004eub.2_Frame_Shift_Del_p.S174fs|STAG2_uc004euc.2_Frame_Shift_Del_p.S174fs|STAG2_uc004eud.2_Frame_Shift_Del_p.S174fs|STAG2_uc004eue.2_Frame_Shift_Del_p.S174fs	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	174					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5																		---	---	---	---
STAG2	10735	broad.mit.edu	37	X	123191971	123191971	+	Intron	DEL	T	-	-	rs6655781		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:123191971delT	uc004etz.3	+						STAG2_uc004eua.2_Intron|STAG2_uc004eub.2_Intron|STAG2_uc004euc.2_Intron|STAG2_uc004eud.2_Intron|STAG2_uc004eue.2_Intron	NM_006603	NP_006594			stromal antigen 2 isoform b						cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5																		---	---	---	---
Unknown	0	broad.mit.edu	37	X	127261004	127261004	+	IGR	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:127261004delC								ACTRT1 (74622 upstream) : None (None downstream)																																			---	---	---	---
AIFM1	9131	broad.mit.edu	37	X	129267606	129267606	+	Intron	DEL	T	-	-	rs66532248		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:129267606delT	uc004evg.2	-						AIFM1_uc011mur.1_Intron|AIFM1_uc011mus.1_Intron|AIFM1_uc004evh.2_Intron|AIFM1_uc004evi.2_Intron|AIFM1_uc004evk.2_Intron	NM_004208	NP_004199			programmed cell death 8 isoform 1						activation of caspase activity|apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytosol|mitochondrial inner membrane|mitochondrial intermembrane space|nucleus|perinuclear region of cytoplasm	DNA binding|electron carrier activity|flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			ovary(4)|central_nervous_system(1)	5																		---	---	---	---
ENOX2	10495	broad.mit.edu	37	X	129779822	129779823	+	Intron	DEL	GA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:129779822_129779823delGA	uc004evw.2	-						ENOX2_uc004evx.2_Intron|ENOX2_uc004evy.2_Intron|ENOX2_uc004evv.2_Intron	NM_182314	NP_872114			ecto-NOX disulfide-thiol exchanger 2 isoform b						cell growth|electron transport chain|regulation of growth|transport|ultradian rhythm	cytosol|external side of plasma membrane|extracellular space	nucleic acid binding|nucleotide binding|protein disulfide oxidoreductase activity			ovary(1)	1																		---	---	---	---
ENOX2	10495	broad.mit.edu	37	X	129804249	129804250	+	Intron	DEL	AG	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:129804249_129804250delAG	uc004evw.2	-						ENOX2_uc004evx.2_Intron|ENOX2_uc004evy.2_Intron|ENOX2_uc004evv.2_Intron	NM_182314	NP_872114			ecto-NOX disulfide-thiol exchanger 2 isoform b						cell growth|electron transport chain|regulation of growth|transport|ultradian rhythm	cytosol|external side of plasma membrane|extracellular space	nucleic acid binding|nucleotide binding|protein disulfide oxidoreductase activity			ovary(1)	1																		---	---	---	---
MOSPD1	56180	broad.mit.edu	37	X	134033048	134033048	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:134033048delT	uc004eyb.2	-						MOSPD1_uc004eya.2_Intron|MOSPD1_uc010nrv.2_Intron|MOSPD1_uc011mvr.1_Intron	NM_019556	NP_062456			motile sperm domain containing 1						negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	integral to membrane|nucleus|perinuclear region of cytoplasm	structural molecule activity			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
ZNF449	203523	broad.mit.edu	37	X	134495119	134495119	+	3'UTR	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:134495119delT	uc004eys.2	+	5					ZNF449_uc004eyt.2_3'UTR|ZNF449_uc004eyu.2_3'UTR	NM_152695	NP_689908			zinc finger protein 449						viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
SLC9A6	10479	broad.mit.edu	37	X	135068099	135068099	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:135068099delC	uc004ezj.2	+						SLC9A6_uc004ezk.2_Intron|SLC9A6_uc011mvx.1_Intron	NM_006359	NP_006350			solute carrier family 9 (sodium/hydrogen						regulation of pH	early endosome membrane|endoplasmic reticulum membrane|integral to membrane|microsome|plasma membrane|recycling endosome membrane	sodium:hydrogen antiporter activity			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
MAP7D3	79649	broad.mit.edu	37	X	135314193	135314194	+	Frame_Shift_Ins	INS	-	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:135314193_135314194insG	uc004ezt.2	-	8	1013_1014	c.922_923insC	c.(922-924)CAGfs	p.Q308fs	MAP7D3_uc004ezs.2_Frame_Shift_Ins_p.Q272fs|MAP7D3_uc011mwc.1_Frame_Shift_Ins_p.Q290fs|MAP7D3_uc010nsa.1_Frame_Shift_Ins_p.Q266fs	NM_024597	NP_078873	Q8IWC1	MA7D3_HUMAN	MAP7 domain containing 3	308						cytoplasm|spindle				ovary(2)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
ARHGEF6	9459	broad.mit.edu	37	X	135764121	135764121	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:135764121delT	uc004fab.2	-	14	1948	c.1486delA	c.(1486-1488)ATAfs	p.I496fs	ARHGEF6_uc011mwd.1_Frame_Shift_Del_p.I369fs|ARHGEF6_uc011mwe.1_Frame_Shift_Del_p.I342fs	NM_004840	NP_004831	Q15052	ARHG6_HUMAN	Rac/Cdc42 guanine nucleotide exchange factor 6	496	PH.				apoptosis|cell junction assembly|induction of apoptosis by extracellular signals|JNK cascade|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity				0	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
FGF13	2258	broad.mit.edu	37	X	138286075	138286075	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:138286075delC	uc004faq.2	-						FGF13_uc004far.2_Intron|FGF13_uc011mwj.1_Intron|FGF13_uc011mwk.1_Intron	NM_001139502	NP_001132974			fibroblast growth factor 13 isoform 3						cell-cell signaling|MAPKKK cascade|nervous system development	cytoplasm|nucleus	growth factor activity|protein kinase activator activity			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
ATP11C	286410	broad.mit.edu	37	X	138840030	138840030	+	Intron	DEL	A	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:138840030delA	uc004faz.2	-						ATP11C_uc004fax.2_Intron|ATP11C_uc004fay.2_Intron|ATP11C_uc004fba.2_Intron	NM_173694	NP_775965			ATPase, class VI, type 11C isoform a						ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(5)|large_intestine(3)	8	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
ATP11C	286410	broad.mit.edu	37	X	138871362	138871364	+	Intron	DEL	AAA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:138871362_138871364delAAA	uc004faz.2	-						ATP11C_uc004fay.2_Intron|ATP11C_uc004fba.2_Intron	NM_173694	NP_775965			ATPase, class VI, type 11C isoform a						ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(5)|large_intestine(3)	8	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
Unknown	0	broad.mit.edu	37	X	140233030	140233032	+	IGR	DEL	AAA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:140233030_140233032delAAA								SPANXB2 (147160 upstream) : LDOC1 (36908 downstream)																																			---	---	---	---
SPANXC	64663	broad.mit.edu	37	X	140357858	140357858	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:140357858delT	uc004fbl.2	-											Homo sapiens nuclear-associated protein SPAN-Xa (SPANX) mRNA, complete cds.							cytoplasm|nucleus					0	Acute lymphoblastic leukemia(192;7.65e-05)																	---	---	---	---
Unknown	0	broad.mit.edu	37	X	142761223	142761224	+	IGR	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:142761223_142761224insT								SLITRK4 (37627 upstream) : SPANXN2 (33832 downstream)																																			---	---	---	---
FMR1	2332	broad.mit.edu	37	X	147009953	147009954	+	Intron	INS	-	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:147009953_147009954insT	uc010nst.2	+						FMR1_uc011mwz.1_Intron|FMR1_uc004fcj.2_Intron|FMR1_uc004fck.3_Intron|FMR1_uc004fcl.3_5'UTR|FMR1_uc011mxa.1_5'Flank	NM_002024	NP_002015			fragile X mental retardation 1						mRNA transport|negative regulation of translational initiation	cytoplasm|mRNA cap binding complex|nucleolus|nucleoplasm|soluble fraction	mRNA binding|protein binding			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)													Fragile_X_syndrome				---	---	---	---
MAGEA11	4110	broad.mit.edu	37	X	148794753	148794754	+	Intron	INS	-	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:148794753_148794754insC	uc004fdq.2	+						HSFX2_uc004fdl.2_Intron|HSFX1_uc004fdm.2_Intron|MAGEA11_uc004fdr.2_Intron	NM_005366	NP_005357			melanoma antigen family A, 11 isoform a							cytoplasm|nucleus	protein binding			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)																	---	---	---	---
MAMLD1	10046	broad.mit.edu	37	X	149637879	149637880	+	Intron	DEL	CT	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:149637879_149637880delCT	uc004fee.1	+						MAMLD1_uc011mxt.1_Intron|MAMLD1_uc011mxu.1_Intron|MAMLD1_uc011mxv.1_Intron|MAMLD1_uc011mxw.1_5'Flank	NM_005491	NP_005482			mastermind-like domain containing 1						male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
VMA21	203547	broad.mit.edu	37	X	150573370	150573370	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:150573370delT	uc004feu.2	+							NM_001017980	NP_001017980			VMA21 vacuolar H+-ATPase homolog						vacuolar proton-transporting V-type ATPase complex assembly	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|integral to membrane|lysosome					0																		---	---	---	---
PASD1	139135	broad.mit.edu	37	X	150770186	150770186	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:150770186delT	uc004fev.3	+							NM_173493	NP_775764			PAS domain containing 1							nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
PASD1	139135	broad.mit.edu	37	X	150816900	150816900	+	Intron	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:150816900delT	uc004fev.3	+							NM_173493	NP_775764			PAS domain containing 1							nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
FLNA	2316	broad.mit.edu	37	X	153586532	153586532	+	Intron	DEL	C	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153586532delC	uc004fkk.2	-						FLNA_uc011mzn.1_Intron|FLNA_uc010nuu.1_Intron	NM_001110556	NP_001104026			filamin A, alpha isoform 2						actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)																	---	---	---	---
G6PD	2539	broad.mit.edu	37	X	153774052	153774055	+	Intron	DEL	AAAA	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153774052_153774055delAAAA	uc004fly.1	-						G6PD_uc004flx.1_Intron|IKBKG_uc011mzr.1_Intron|IKBKG_uc010nva.2_5'Flank|IKBKG_uc004fmb.3_5'Flank|IKBKG_uc011mzs.1_5'Flank|IKBKG_uc004fma.3_5'Flank|IKBKG_uc004fmc.3_5'Flank|IKBKG_uc004fmd.2_5'Flank	NM_001042351	NP_001035810			glucose-6-phosphate dehydrogenase isoform b						cellular response to oxidative stress|cholesterol biosynthetic process|cytokine production|erythrocyte maturation|glucose 6-phosphate metabolic process|glutathione metabolic process|negative regulation of protein glutathionylation|pentose-phosphate shunt, oxidative branch|ribose phosphate biosynthetic process	centrosome|cytosol|internal side of plasma membrane|intracellular membrane-bounded organelle	glucose binding|glucose-6-phosphate dehydrogenase activity|NADP binding|protein homodimerization activity			ovary(4)	4	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)																	---	---	---	---
F8	2157	broad.mit.edu	37	X	154091467	154091467	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:154091467delT	uc004fmt.2	-	23	6636	c.6465delA	c.(6463-6465)AAAfs	p.K2155fs	F8_uc004fms.2_Frame_Shift_Del_p.K20fs	NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	2155	F5/8 type C 1.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)													---	---	---	---
Unknown	0	broad.mit.edu	37	Y	28687103	28687103	+	IGR	DEL	G	-	-			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrY:28687103delG								None (None upstream) : None (None downstream)																																			---	---	---	---
AGRN	375790	broad.mit.edu	37	1	977548	977548	+	Intron	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:977548C>T	uc001ack.1	+							NM_198576	NP_940978			agrin precursor						axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)														---	---	---	---
CPSF3L	54973	broad.mit.edu	37	1	1249291	1249291	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:1249291T>C	uc001aee.1	-	9	836	c.778A>G	c.(778-780)AAC>GAC	p.N260D	CPSF3L_uc009vjy.1_RNA|CPSF3L_uc001aef.1_Missense_Mutation_p.N266D|CPSF3L_uc009vjz.1_Missense_Mutation_p.N238D|CPSF3L_uc010nyj.1_Missense_Mutation_p.N231D|CPSF3L_uc001aeg.1_Missense_Mutation_p.N136D|CPSF3L_uc001aeh.1_Missense_Mutation_p.N159D|CPSF3L_uc001aei.1_Missense_Mutation_p.N162D|CPSF3L_uc001aej.1_Missense_Mutation_p.N87D|CPSF3L_uc001aek.1_Missense_Mutation_p.N2D	NM_017871	NP_060341	Q5TA45	INT11_HUMAN	cleavage and polyadenylation specific factor	260						Golgi apparatus|nucleus	hydrolase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;6.71e-35)|OV - Ovarian serous cystadenocarcinoma(86;4.35e-21)|Colorectal(212;0.000166)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.00235)|BRCA - Breast invasive adenocarcinoma(365;0.00255)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0349)|Lung(427;0.201)														---	---	---	---
MXRA8	54587	broad.mit.edu	37	1	1290349	1290349	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:1290349C>T	uc001aew.2	-	5	693	c.662G>A	c.(661-663)CGC>CAC	p.R221H	MXRA8_uc001aex.3_Missense_Mutation_p.R221H|MXRA8_uc001aey.3_Missense_Mutation_p.R221H|MXRA8_uc010nyl.1_Missense_Mutation_p.R221H|MXRA8_uc001aez.2_Missense_Mutation_p.R120H|MXRA8_uc001afa.2_Missense_Mutation_p.R212H	NM_032348	NP_115724	Q9BRK3	MXRA8_HUMAN	matrix-remodelling associated 8 precursor	221	Ig-like V-type 2.|Extracellular (Potential).					integral to membrane					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)														---	---	---	---
PRKCZ	5590	broad.mit.edu	37	1	1987914	1987914	+	Intron	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:1987914C>A	uc001aiq.2	+							NM_002744	NP_002735			protein kinase C, zeta isoform 1						anti-apoptosis|intracellular signal transduction|negative regulation of insulin receptor signaling pathway|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein complex assembly|peptidyl-serine phosphorylation|platelet activation	endosome	ATP binding|protein kinase C activity|zinc ion binding			central_nervous_system(4)|large_intestine(2)	6	all_cancers(77;0.000177)|all_epithelial(69;6.41e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;1.14e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.96e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.3e-23)|GBM - Glioblastoma multiforme(42;2.85e-08)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00294)|BRCA - Breast invasive adenocarcinoma(365;0.00493)|STAD - Stomach adenocarcinoma(132;0.00669)|KIRC - Kidney renal clear cell carcinoma(229;0.0411)|Lung(427;0.213)														---	---	---	---
SKI	6497	broad.mit.edu	37	1	2235477	2235477	+	Silent	SNP	C	T	T	rs150985728	byFrequency	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:2235477C>T	uc001aja.3	+	4	1482	c.1410C>T	c.(1408-1410)CCC>CCT	p.P470P		NM_003036	NP_003027	P12755	SKI_HUMAN	v-ski sarcoma viral oncogene homolog	470					anterior/posterior axis specification|BMP signaling pathway|bone morphogenesis|cell motility|cell proliferation|embryonic limb morphogenesis|face morphogenesis|lens morphogenesis in camera-type eye|myelination in peripheral nervous system|myotube differentiation|negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of fibroblast proliferation|negative regulation of osteoblast differentiation|negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|neural tube closure|nose morphogenesis|olfactory bulb development|palate development|positive regulation of DNA binding|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|protein homotrimerization|regulation of apoptosis|retina development in camera-type eye|skeletal muscle fiber development|SMAD protein signal transduction|somatic stem cell maintenance|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|PML body|transcription factor complex|transcriptional repressor complex	histone deacetylase inhibitor activity|nucleotide binding|protein domain specific binding|protein kinase binding|repressing transcription factor binding|SMAD binding|transcription corepressor activity|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding			lung(1)|central_nervous_system(1)	2	all_cancers(77;0.000139)|all_epithelial(69;4.45e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)			Epithelial(90;2.14e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.72e-29)|GBM - Glioblastoma multiforme(42;2.45e-08)|Colorectal(212;5.33e-05)|COAD - Colon adenocarcinoma(227;0.000228)|Kidney(185;0.00268)|BRCA - Breast invasive adenocarcinoma(365;0.00471)|STAD - Stomach adenocarcinoma(132;0.0147)|KIRC - Kidney renal clear cell carcinoma(229;0.0385)|Lung(427;0.207)														---	---	---	---
MORN1	79906	broad.mit.edu	37	1	2317268	2317268	+	Missense_Mutation	SNP	C	T	T	rs147757432		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:2317268C>T	uc001ajb.1	-	5	448	c.427G>A	c.(427-429)GGC>AGC	p.G143S	MORN1_uc009vld.2_Missense_Mutation_p.G119S|MORN1_uc001ajd.1_Missense_Mutation_p.G143S|MORN1_uc010nyy.1_Silent_p.T85T	NM_024848	NP_079124	Q5T089	MORN1_HUMAN	MORN repeat containing 1	143	MORN 5.									ovary(2)|central_nervous_system(1)	3	all_cancers(77;0.000194)|all_epithelial(69;9.96e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;3.3e-15)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;2.21e-37)|OV - Ovarian serous cystadenocarcinoma(86;5.01e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00137)|BRCA - Breast invasive adenocarcinoma(365;0.00488)|STAD - Stomach adenocarcinoma(132;0.00665)|KIRC - Kidney renal clear cell carcinoma(229;0.0203)|Lung(427;0.212)														---	---	---	---
MMEL1	79258	broad.mit.edu	37	1	2528129	2528129	+	Splice_Site	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:2528129C>A	uc001ajy.2	-	14	1487	c.1273_splice	c.e14-1	p.A425_splice	MMEL1_uc009vlg.1_Splice_Site	NM_033467	NP_258428			membrane metallo-endopeptidase-like 1						proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity				0	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)														---	---	---	---
LRRC47	57470	broad.mit.edu	37	1	3703754	3703754	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:3703754C>T	uc001akx.1	-	2	764	c.736G>A	c.(736-738)GTC>ATC	p.V246I		NM_020710	NP_065761	Q8N1G4	LRC47_HUMAN	leucine rich repeat containing 47	246	LRR 7.				translation		phenylalanine-tRNA ligase activity|RNA binding			large_intestine(1)|ovary(1)	2	all_cancers(77;0.0375)|Ovarian(185;0.0634)|all_lung(157;0.208)|Lung NSC(156;0.21)	all_epithelial(116;1.34e-16)|all_lung(118;2.53e-06)|Lung NSC(185;0.00028)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.0743)|Ovarian(437;0.127)		Epithelial(90;5.49e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.43e-22)|GBM - Glioblastoma multiforme(42;3.69e-16)|Colorectal(212;1.21e-05)|COAD - Colon adenocarcinoma(227;5.87e-05)|Kidney(185;0.000367)|BRCA - Breast invasive adenocarcinoma(365;0.000704)|KIRC - Kidney renal clear cell carcinoma(229;0.00567)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.124)														---	---	---	---
LRRC47	57470	broad.mit.edu	37	1	3703780	3703780	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:3703780A>G	uc001akx.1	-	2	738	c.710T>C	c.(709-711)CTG>CCG	p.L237P		NM_020710	NP_065761	Q8N1G4	LRC47_HUMAN	leucine rich repeat containing 47	237	LRR 7.				translation		phenylalanine-tRNA ligase activity|RNA binding			large_intestine(1)|ovary(1)	2	all_cancers(77;0.0375)|Ovarian(185;0.0634)|all_lung(157;0.208)|Lung NSC(156;0.21)	all_epithelial(116;1.34e-16)|all_lung(118;2.53e-06)|Lung NSC(185;0.00028)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.0743)|Ovarian(437;0.127)		Epithelial(90;5.49e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.43e-22)|GBM - Glioblastoma multiforme(42;3.69e-16)|Colorectal(212;1.21e-05)|COAD - Colon adenocarcinoma(227;5.87e-05)|Kidney(185;0.000367)|BRCA - Breast invasive adenocarcinoma(365;0.000704)|KIRC - Kidney renal clear cell carcinoma(229;0.00567)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.124)														---	---	---	---
PLEKHG5	57449	broad.mit.edu	37	1	6534577	6534577	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:6534577A>T	uc001ano.1	-	7	642	c.541T>A	c.(541-543)TCC>ACC	p.S181T	PLEKHG5_uc001ann.1_Missense_Mutation_p.S162T|PLEKHG5_uc001anq.1_Missense_Mutation_p.S202T|PLEKHG5_uc001anp.1_Missense_Mutation_p.S202T|PLEKHG5_uc001anj.1_5'Flank|PLEKHG5_uc009vma.1_5'UTR|PLEKHG5_uc010nzr.1_Missense_Mutation_p.S194T|PLEKHG5_uc001ank.1_Missense_Mutation_p.S125T|PLEKHG5_uc009vmb.1_Missense_Mutation_p.S125T|PLEKHG5_uc001anl.1_Missense_Mutation_p.S125T|PLEKHG5_uc001anm.1_Missense_Mutation_p.S125T	NM_001042663	NP_001036128	O94827	PKHG5_HUMAN	pleckstrin homology domain containing family G	181					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)														---	---	---	---
SLC45A1	50651	broad.mit.edu	37	1	8384496	8384496	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:8384496C>T	uc001apb.2	+	1	107	c.107C>T	c.(106-108)ACA>ATA	p.T36I		NM_001080397	NP_001073866	Q9Y2W3	S45A1_HUMAN	DNB5	36					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
RERE	473	broad.mit.edu	37	1	8420006	8420006	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:8420006G>A	uc001ape.2	-	20	4246	c.3436C>T	c.(3436-3438)CGG>TGG	p.R1146W	RERE_uc001apf.2_Missense_Mutation_p.R1146W|RERE_uc001apd.2_Missense_Mutation_p.R592W	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	1146					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)														---	---	---	---
UBE4B	10277	broad.mit.edu	37	1	10240023	10240023	+	3'UTR	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:10240023G>A	uc001aqs.3	+	28					UBE4B_uc001aqr.3_3'UTR|UBE4B_uc010oai.1_RNA|UBE4B_uc010oaj.1_3'UTR|UBE4B_uc001aqu.2_3'UTR	NM_001105562	NP_001099032			ubiquitination factor E4B isoform 1						apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			ovary(2)|skin(2)	4		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)														---	---	---	---
TARDBP	23435	broad.mit.edu	37	1	11082567	11082567	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:11082567C>T	uc001art.2	+	6	1235	c.1101C>T	c.(1099-1101)TTC>TTT	p.F367F	TARDBP_uc010oap.1_Silent_p.F251F	NM_007375	NP_031401	Q13148	TADBP_HUMAN	TAR DNA binding protein	367	Gly-rich.				3'-UTR-mediated mRNA stabilization|cell death|mRNA processing|negative regulation by host of viral transcription|RNA splicing|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0578)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.37e-07)|COAD - Colon adenocarcinoma(227;7.38e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)														---	---	---	---
MTOR	2475	broad.mit.edu	37	1	11307756	11307756	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:11307756T>C	uc001asd.2	-	8	1272	c.1151A>G	c.(1150-1152)AAG>AGG	p.K384R		NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	384					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29																		---	---	---	---
MTHFR	4524	broad.mit.edu	37	1	11863504	11863504	+	Intron	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:11863504G>A	uc001atc.1	-						MTHFR_uc001atb.1_5'Flank|MTHFR_uc001atd.1_RNA|MTHFR_uc009vnd.1_Intron|CLCN6_uc009vne.1_5'Flank|CLCN6_uc009vnf.1_5'Flank|CLCN6_uc009vng.1_5'Flank|CLCN6_uc009vnh.1_5'Flank|CLCN6_uc001ate.3_5'Flank|CLCN6_uc010oat.1_5'Flank|CLCN6_uc010oau.1_5'Flank	NM_005957	NP_005948			5,10-methylenetetrahydrofolate reductase						blood circulation|folic acid metabolic process	cytosol	methylenetetrahydrofolate reductase (NADPH) activity|protein binding				0	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00826)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)	Benazepril(DB00542)|Cyanocobalamin(DB00115)|Folic Acid(DB00158)|L-Methionine(DB00134)|Menadione(DB00170)|Methotrexate(DB00563)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)|Raltitrexed(DB00293)|Riboflavin(DB00140)|S-Adenosylmethionine(DB00118)|Tetrahydrofolic acid(DB00116)													---	---	---	---
CLCN6	1185	broad.mit.edu	37	1	11887152	11887152	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:11887152G>T	uc001ate.3	+	10	827	c.714G>T	c.(712-714)AAG>AAT	p.K238N	CLCN6_uc009vnf.1_Nonsense_Mutation_p.E242*|CLCN6_uc009vng.1_Intron|CLCN6_uc009vnh.1_Missense_Mutation_p.K238N|CLCN6_uc010oat.1_Intron|CLCN6_uc010oau.1_Missense_Mutation_p.K216N	NM_001286	NP_001277	P51797	CLCN6_HUMAN	chloride channel 6 isoform ClC-6a	238					cell volume homeostasis|signal transduction	endosome membrane|integral to membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity				0	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000816)|KIRC - Kidney renal clear cell carcinoma(229;0.00268)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
VPS13D	55187	broad.mit.edu	37	1	12337111	12337111	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:12337111T>C	uc001atv.2	+	19	3607	c.3466T>C	c.(3466-3468)TAC>CAC	p.Y1156H	VPS13D_uc001atw.2_Missense_Mutation_p.Y1156H|VPS13D_uc001atx.2_Missense_Mutation_p.Y344H	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	1156					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)														---	---	---	---
KAZ	23254	broad.mit.edu	37	1	15430600	15430600	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:15430600G>A	uc001avm.3	+	13	2244	c.1963G>A	c.(1963-1965)GCC>ACC	p.A655T	KAZ_uc001avs.3_Missense_Mutation_p.A102T	NM_201628	NP_963922	Q674X7	KAZRN_HUMAN	kazrin isoform E	655	SAM 3.				keratinization	cornified envelope|cytoplasm|desmosome|nucleus					0																		---	---	---	---
ZBTB17	7709	broad.mit.edu	37	1	16269901	16269901	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:16269901C>A	uc001axl.3	-	12	1929	c.1690G>T	c.(1690-1692)GGC>TGC	p.G564C	ZBTB17_uc010obq.1_Missense_Mutation_p.G481C|ZBTB17_uc010obr.1_Missense_Mutation_p.G564C|ZBTB17_uc010obs.1_Missense_Mutation_p.G488C	NM_003443	NP_003434	Q13105	ZBT17_HUMAN	zinc finger and BTB domain containing 17	564	C2H2-type 10.				negative regulation of cell cycle	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|Colorectal(212;4.12e-07)|COAD - Colon adenocarcinoma(227;2.43e-05)|BRCA - Breast invasive adenocarcinoma(304;9.97e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
ZBTB17	7709	broad.mit.edu	37	1	16270392	16270392	+	Splice_Site	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:16270392T>C	uc001axl.3	-	10	1611	c.1372_splice	c.e10-1	p.V458_splice	ZBTB17_uc010obq.1_Splice_Site_p.V375_splice|ZBTB17_uc010obr.1_Splice_Site_p.V458_splice|ZBTB17_uc010obs.1_Splice_Site_p.V382_splice|ZBTB17_uc010obt.1_3'UTR|ZBTB17_uc010obu.1_3'UTR	NM_003443	NP_003434			zinc finger and BTB domain containing 17						negative regulation of cell cycle	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|Colorectal(212;4.12e-07)|COAD - Colon adenocarcinoma(227;2.43e-05)|BRCA - Breast invasive adenocarcinoma(304;9.97e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
PADI3	51702	broad.mit.edu	37	1	17609341	17609341	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:17609341G>A	uc001bai.2	+	16	1802	c.1762G>A	c.(1762-1764)GTG>ATG	p.V588M		NM_016233	NP_057317	Q9ULW8	PADI3_HUMAN	peptidyl arginine deiminase, type III	588					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			ovary(1)|breast(1)	2		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;1.17e-05)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)													---	---	---	---
KLHDC7A	127707	broad.mit.edu	37	1	18808480	18808480	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:18808480A>G	uc001bax.2	+	1	1057	c.1005A>G	c.(1003-1005)CAA>CAG	p.Q335Q	KLHDC7A_uc009vpg.2_Silent_p.Q117Q	NM_152375	NP_689588	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	335	Kelch 1.					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
TAS1R2	80834	broad.mit.edu	37	1	19166520	19166520	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:19166520A>G	uc001bba.1	-	6	2094	c.2093T>C	c.(2092-2094)CTG>CCG	p.L698P		NM_152232	NP_689418	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2 precursor	698	Helical; Name=4; (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)													---	---	---	---
NBL1	4681	broad.mit.edu	37	1	19983449	19983449	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:19983449A>G	uc001bck.1	+	4	525	c.370A>G	c.(370-372)AAG>GAG	p.K124E	NBL1_uc009vpl.1_Missense_Mutation_p.K125E|NBL1_uc001bcj.1_Missense_Mutation_p.K160E|NBL1_uc009vpm.1_Missense_Mutation_p.K125E	NM_005380	NP_005371	P41271	NBL1_HUMAN	neuroblastoma, suppression of tumorigenicity 1 2	124						extracellular region				ovary(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00043)|Ovarian(437;0.00373)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;5.9e-05)|Kidney(64;0.000173)|GBM - Glioblastoma multiforme(114;0.0012)|KIRC - Kidney renal clear cell carcinoma(64;0.0026)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
HSPG2	3339	broad.mit.edu	37	1	22179477	22179477	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:22179477G>A	uc001bfj.2	-	51	6566	c.6526C>T	c.(6526-6528)CCC>TCC	p.P2176S	HSPG2_uc009vqd.2_Missense_Mutation_p.P2177S	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2176	Ig-like C2-type 7.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)													---	---	---	---
E2F2	1870	broad.mit.edu	37	1	23845552	23845552	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:23845552T>C	uc001bhe.1	-	5	1236	c.808A>G	c.(808-810)AAG>GAG	p.K270E		NM_004091	NP_004082	Q14209	E2F2_HUMAN	E2F transcription factor 2	270	Dimerization (Potential).				G1 phase of mitotic cell cycle|transcription initiation from RNA polymerase II promoter	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(2)|skin(2)	4		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.52e-24)|Colorectal(126;6.25e-08)|COAD - Colon adenocarcinoma(152;3.42e-06)|GBM - Glioblastoma multiforme(114;8.98e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00102)|KIRC - Kidney renal clear cell carcinoma(1967;0.00366)|STAD - Stomach adenocarcinoma(196;0.0132)|READ - Rectum adenocarcinoma(331;0.0652)|Lung(427;0.0888)|LUSC - Lung squamous cell carcinoma(448;0.19)														---	---	---	---
CLIC4	25932	broad.mit.edu	37	1	25166340	25166340	+	Intron	SNP	T	C	C	rs41268781		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:25166340T>C	uc001bjo.2	+						CLIC4_uc001bjn.2_Intron|CLIC4_uc001bjp.1_Intron	NM_013943	NP_039234			chloride intracellular channel 4						cellular response to calcium ion|establishment or maintenance of apical/basal cell polarity|keratinocyte differentiation|negative regulation of cell migration|regulation of cytoskeleton organization	actin cytoskeleton|apical part of cell|cell surface|cell-cell junction|centrosome|chloride channel complex|cytoplasmic vesicle membrane|cytosol|microvillus|midbody|mitochondrion|nuclear matrix|perinuclear region of cytoplasm|soluble fraction	voltage-gated chloride channel activity				0		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000778)|all_lung(284;0.00106)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0479)|OV - Ovarian serous cystadenocarcinoma(117;1.06e-24)|Colorectal(126;1.03e-07)|COAD - Colon adenocarcinoma(152;4.93e-06)|STAD - Stomach adenocarcinoma(196;0.000418)|GBM - Glioblastoma multiforme(114;0.000451)|BRCA - Breast invasive adenocarcinoma(304;0.00215)|KIRC - Kidney renal clear cell carcinoma(1967;0.00216)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.18)														---	---	---	---
C1orf63	57035	broad.mit.edu	37	1	25573425	25573425	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:25573425C>A	uc001bjw.2	-	2	282	c.30G>T	c.(28-30)CCG>CCT	p.P10P		NM_020317	NP_064713	Q9BUV0	CA063_HUMAN	hypothetical protein LOC57035	10										pancreas(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;7.9e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;6.43e-07)|STAD - Stomach adenocarcinoma(196;0.000333)|BRCA - Breast invasive adenocarcinoma(304;0.000443)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.000932)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)														---	---	---	---
SESN2	83667	broad.mit.edu	37	1	28599313	28599313	+	Intron	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:28599313C>T	uc001bps.2	+							NM_031459	NP_113647			sestrin 2						cell cycle arrest	cytoplasm|nucleus				skin(3)|ovary(2)|pancreas(1)|lung(1)	7		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;4.76e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;2.98e-22)|Colorectal(126;3.04e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00279)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00595)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
ZSCAN20	7579	broad.mit.edu	37	1	33955113	33955113	+	Intron	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:33955113C>T	uc001bxj.3	+						ZSCAN20_uc001bxk.2_Intron|ZSCAN20_uc009vui.2_Intron	NM_145238	NP_660281			zinc finger protein 31						viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)																---	---	---	---
EIF2C1	26523	broad.mit.edu	37	1	36358858	36358858	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:36358858T>C	uc001bzl.2	+	4	704	c.491T>C	c.(490-492)ATG>ACG	p.M164T	EIF2C1_uc001bzk.2_Missense_Mutation_p.M89T|EIF2C1_uc009vuy.2_5'Flank	NM_012199	NP_036331	Q9UL18	AGO1_HUMAN	eukaryotic translation initiation factor 2C, 1	164					negative regulation of translation involved in gene silencing by miRNA|nuclear-transcribed mRNA catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|polysome	protein binding|RNA binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)																---	---	---	---
MRPS15	64960	broad.mit.edu	37	1	36921835	36921835	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:36921835G>A	uc001cas.2	-	7	753	c.589C>T	c.(589-591)CGA>TGA	p.R197*		NM_031280	NP_112570	P82914	RT15_HUMAN	mitochondrial ribosomal protein S15 precursor	197					translation	mitochondrial small ribosomal subunit|nuclear membrane	structural constituent of ribosome			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)																---	---	---	---
CSF3R	1441	broad.mit.edu	37	1	36938264	36938264	+	Missense_Mutation	SNP	G	A	A	rs150616658		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:36938264G>A	uc001caw.1	-	7	875	c.697C>T	c.(697-699)CGG>TGG	p.R233W	CSF3R_uc001cat.1_5'Flank|CSF3R_uc009vvc.1_5'Flank|CSF3R_uc001cau.1_5'Flank|CSF3R_uc001cav.1_Missense_Mutation_p.R233W|CSF3R_uc001cax.1_Missense_Mutation_p.R233W|CSF3R_uc001cay.1_Missense_Mutation_p.R233W	NM_000760	NP_000751	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor isoform a	233	Extracellular (Potential).				cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(2)|ovary(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)													---	---	---	---
MACF1	23499	broad.mit.edu	37	1	39844153	39844153	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:39844153G>T	uc010oiu.1	+	17	8685	c.8554G>T	c.(8554-8556)GGA>TGA	p.G2852*	MACF1_uc010ois.1_Nonsense_Mutation_p.G2350*|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	4417				SILPSVG -> EYRLFKI (in Ref. 5; BAA86565).	cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)															---	---	---	---
KIAA0754	643314	broad.mit.edu	37	1	39876405	39876405	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:39876405A>G	uc009vvt.1	+	1	1230	c.468A>G	c.(466-468)TCA>TCG	p.S156S	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc010oiu.1_Intron	NM_015038	NP_055853	O94854	K0754_HUMAN	hypothetical protein LOC643314	20											0	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)															---	---	---	---
HPCAL4	51440	broad.mit.edu	37	1	40149624	40149624	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:40149624C>T	uc001cdr.2	-	3	483	c.363G>A	c.(361-363)ATG>ATA	p.M121I	HPCAL4_uc010oix.1_Intron	NM_016257	NP_057341	Q9UM19	HPCL4_HUMAN	hippocalcin-like protein 4	121	EF-hand 3.				central nervous system development	intracellular	calcium ion binding			central_nervous_system(1)	1	all_cancers(7;4.65e-13)|Lung NSC(20;2.88e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)															---	---	---	---
TRIT1	54802	broad.mit.edu	37	1	40309854	40309854	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:40309854A>G	uc010oiz.1	-	10	1167	c.1153T>C	c.(1153-1155)TAC>CAC	p.Y385H	TRIT1_uc001cec.3_RNA|TRIT1_uc001ced.3_Missense_Mutation_p.Y81H|TRIT1_uc001cee.3_RNA|TRIT1_uc001cef.3_RNA|TRIT1_uc001ceg.3_Missense_Mutation_p.Y139H|TRIT1_uc001ceh.3_Missense_Mutation_p.Y139H|TRIT1_uc009vvv.2_Missense_Mutation_p.Y218H|TRIT1_uc001cei.3_Missense_Mutation_p.Y139H|TRIT1_uc001ceq.2_Missense_Mutation_p.Y81H|TRIT1_uc001cek.2_Missense_Mutation_p.Y81H|TRIT1_uc009vvx.2_RNA|TRIT1_uc001cel.2_Intron|TRIT1_uc001cem.2_Missense_Mutation_p.Y303H|TRIT1_uc001cen.2_Missense_Mutation_p.Y139H|TRIT1_uc001ceo.2_Missense_Mutation_p.Y139H|TRIT1_uc001cep.2_Missense_Mutation_p.Y139H	NM_017646	NP_060116	Q9H3H1	MOD5_HUMAN	tRNA isopentenyltransferase 1 precursor	385					tRNA processing	mitochondrion	ATP binding|metal ion binding|tRNA dimethylallyltransferase activity			ovary(1)	1	all_cancers(7;4.55e-14)|all_lung(5;1.23e-16)|all_epithelial(6;2.17e-16)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;3.29e-18)|Epithelial(16;3.07e-17)|all cancers(16;6.21e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)															---	---	---	---
ZNF642	339559	broad.mit.edu	37	1	40961584	40961584	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:40961584T>C	uc001cfo.2	+	6	1728	c.1434T>C	c.(1432-1434)CAT>CAC	p.H478H	ZNF642_uc009vwb.2_Silent_p.H478H|ZNF642_uc010ojk.1_Silent_p.H479H	NM_198494	NP_940896	Q49AA0	ZN642_HUMAN	zinc finger protein 642	478	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;8.81e-19)															---	---	---	---
LEPRE1	64175	broad.mit.edu	37	1	43224593	43224593	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:43224593T>C	uc001chv.2	-	4	983	c.870A>G	c.(868-870)CCA>CCG	p.P290P	LEPRE1_uc001chw.2_Silent_p.P290P|LEPRE1_uc001chx.3_Silent_p.P290P	NM_022356	NP_071751	Q32P28	P3H1_HUMAN	leprecan 1 isoform 1	290					negative regulation of cell proliferation	endoplasmic reticulum|proteinaceous extracellular matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			ovary(3)|lung(1)	4	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)			L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)													---	---	---	---
ZNF691	51058	broad.mit.edu	37	1	43317265	43317265	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:43317265C>T	uc001cih.2	+	2	768	c.717C>T	c.(715-717)GGC>GGT	p.G239G	ZNF691_uc001cig.2_Silent_p.G212G|ZNF691_uc009vwm.2_Silent_p.G232G	NM_015911	NP_056995	Q5VV52	ZN691_HUMAN	zinc finger protein 691	243	C2H2-type 5.					nucleus	DNA binding|zinc ion binding			ovary(2)	2	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)																---	---	---	---
ELOVL1	64834	broad.mit.edu	37	1	43829798	43829798	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:43829798A>G	uc001ciz.2	-	9	872	c.629T>C	c.(628-630)GTC>GCC	p.V210A	ELOVL1_uc001cja.2_Missense_Mutation_p.V210A|ELOVL1_uc001cjb.2_Missense_Mutation_p.V210A|ELOVL1_uc001cjc.2_RNA|ELOVL1_uc010okh.1_Missense_Mutation_p.V183A	NM_022821	NP_073732	Q9BW60	ELOV1_HUMAN	elongation of very long chain fatty acids-like	210	Helical; (Potential).				fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|sphingolipid biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	integral to endoplasmic reticulum membrane	fatty acid elongase activity|protein binding				0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)																---	---	---	---
KIAA0467	23334	broad.mit.edu	37	1	43896402	43896402	+	Silent	SNP	C	T	T	rs147043685		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:43896402C>T	uc001cjk.1	+	17	2481	c.2019C>T	c.(2017-2019)TCC>TCT	p.S673S		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	1572						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)																---	---	---	---
KDM4A	9682	broad.mit.edu	37	1	44163664	44163664	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:44163664C>T	uc001cjx.2	+	19	2987	c.2821C>T	c.(2821-2823)CTT>TTT	p.L941F	KDM4A_uc010oki.1_Intron	NM_014663	NP_055478	O75164	KDM4A_HUMAN	jumonji domain containing 2A	941	Tudor 1.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleolus	histone demethylase activity (H3-K36 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			skin(1)	1																		---	---	---	---
IPO13	9670	broad.mit.edu	37	1	44415386	44415386	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:44415386G>A	uc001ckx.2	+	2	1177	c.382G>A	c.(382-384)GCC>ACC	p.A128T		NM_014652	NP_055467	O94829	IPO13_HUMAN	importin 13	128					protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)																---	---	---	---
DPH2	1802	broad.mit.edu	37	1	44437275	44437275	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:44437275T>C	uc001ckz.2	+	4	896	c.701T>C	c.(700-702)CTG>CCG	p.L234P	DPH2_uc001cla.2_Intron|DPH2_uc010okk.1_Missense_Mutation_p.L99P|DPH2_uc001clb.2_Missense_Mutation_p.L158P	NM_001384	NP_001375	Q9BQC3	DPH2_HUMAN	diphthamide biosynthesis protein 2 isoform a	234					peptidyl-diphthamide biosynthetic process from peptidyl-histidine	cytoplasm				ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)																---	---	---	---
B4GALT2	8704	broad.mit.edu	37	1	44447558	44447558	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:44447558C>T	uc001clg.2	+	3	881	c.511C>T	c.(511-513)CGG>TGG	p.R171W	B4GALT2_uc001clh.2_Missense_Mutation_p.R105W|B4GALT2_uc010okl.1_Missense_Mutation_p.R200W|B4GALT2_uc001cli.2_Missense_Mutation_p.R171W	NM_003780	NP_003771	O60909	B4GT2_HUMAN	UDP-Gal:betaGlcNAc beta 1,4-	171	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|lactose synthase activity|metal ion binding|N-acetyllactosamine synthase activity			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			N-Acetyl-D-glucosamine(DB00141)													---	---	---	---
DMAP1	55929	broad.mit.edu	37	1	44684858	44684858	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:44684858C>T	uc001clq.1	+	7	931	c.851C>T	c.(850-852)ACG>ATG	p.T284M	DMAP1_uc001clr.1_Missense_Mutation_p.T284M|DMAP1_uc001cls.1_Missense_Mutation_p.T284M|DMAP1_uc010oku.1_Missense_Mutation_p.T274M	NM_001034024	NP_001029196	Q9NPF5	DMAP1_HUMAN	DNA methyltransferase 1 associated protein 1	284					DNA methylation|histone H2A acetylation|histone H4 acetylation|negative regulation of transcription, DNA-dependent|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex	DNA binding|protein binding				0	Acute lymphoblastic leukemia(166;0.155)																	---	---	---	---
KIF2C	11004	broad.mit.edu	37	1	45218915	45218915	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:45218915C>A	uc001cmg.3	+	6	666	c.551C>A	c.(550-552)CCT>CAT	p.P184H	KIF2C_uc010olb.1_Intron|KIF2C_uc010olc.1_Missense_Mutation_p.P71H|KIF2C_uc001cmh.3_Missense_Mutation_p.P130H	NM_006845	NP_006836	Q99661	KIF2C_HUMAN	kinesin family member 2C	184	Globular (Potential).				blood coagulation|cell division|cell proliferation|chromosome segregation|establishment or maintenance of microtubule cytoskeleton polarity|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|kinesin complex|microtubule|nucleus	ATP binding|centromeric DNA binding|microtubule motor activity|microtubule plus-end binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)																	---	---	---	---
ZSWIM5	57643	broad.mit.edu	37	1	45504669	45504669	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:45504669G>A	uc001cnd.2	-	8	2061	c.1833C>T	c.(1831-1833)TGC>TGT	p.C611C		NM_020883	NP_065934	Q9P217	ZSWM5_HUMAN	zinc finger, SWIM domain containing 5	611							zinc ion binding				0	Acute lymphoblastic leukemia(166;0.155)																	---	---	---	---
GPBP1L1	60313	broad.mit.edu	37	1	46094046	46094046	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:46094046A>G	uc001coq.2	-	13	2668	c.1307T>C	c.(1306-1308)TTG>TCG	p.L436S	GPBP1L1_uc001coo.2_Missense_Mutation_p.L180S	NM_021639	NP_067652	Q9HC44	GPBL1_HUMAN	GC-rich promoter binding protein 1-like 1	436					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)																	---	---	---	---
GPBP1L1	60313	broad.mit.edu	37	1	46095321	46095321	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:46095321T>C	uc001coq.2	-	12	2560	c.1199A>G	c.(1198-1200)TAT>TGT	p.Y400C	GPBP1L1_uc001coo.2_Missense_Mutation_p.Y144C	NM_021639	NP_067652	Q9HC44	GPBL1_HUMAN	GC-rich promoter binding protein 1-like 1	400					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)																	---	---	---	---
MAST2	23139	broad.mit.edu	37	1	46500422	46500422	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:46500422C>T	uc001cov.2	+	29	4364	c.4081C>T	c.(4081-4083)CGG>TGG	p.R1361W	MAST2_uc001cow.2_Missense_Mutation_p.R1360W|MAST2_uc001cpa.2_Intron	NM_015112	NP_055927	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase	1361					regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			ovary(5)|lung(3)|stomach(2)|breast(1)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)																	---	---	---	---
MKNK1	8569	broad.mit.edu	37	1	47046238	47046238	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:47046238G>T	uc001cqb.2	-	4	442	c.198C>A	c.(196-198)GCC>GCA	p.A66A	MKNK1_uc010omd.1_5'UTR|MKNK1_uc001cqc.2_Silent_p.A66A|MKNK1_uc009vyi.2_Silent_p.A66A|MKNK1_uc010ome.1_5'UTR|MKNK1_uc009vyj.2_Intron|MKNK1_uc001cqd.2_Silent_p.A54A|MKNK1_uc010omf.1_Silent_p.A66A	NM_003684	NP_003675	Q9BUB5	MKNK1_HUMAN	MAP kinase-interacting serine/threonine kinase 1	66	Protein kinase.				intracellular protein kinase cascade|peptidyl-serine phosphorylation|regulation of translation	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)	2	Acute lymphoblastic leukemia(166;0.155)																	---	---	---	---
CYP4Z1	199974	broad.mit.edu	37	1	47571852	47571852	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:47571852C>T	uc001cqu.1	+	9	1123	c.1120C>T	c.(1120-1122)CGC>TGC	p.R374C		NM_178134	NP_835235	Q86W10	CP4Z1_HUMAN	cytochrome P450 4Z1	374	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			skin(1)	1																		---	---	---	---
ELAVL4	1996	broad.mit.edu	37	1	50663114	50663114	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:50663114C>T	uc001csb.2	+	6	1016	c.748C>T	c.(748-750)CTT>TTT	p.L250F	ELAVL4_uc001cry.3_Missense_Mutation_p.L253F|ELAVL4_uc001crz.3_Missense_Mutation_p.L250F|ELAVL4_uc001csa.3_Missense_Mutation_p.L267F|ELAVL4_uc001csc.3_Missense_Mutation_p.L250F|ELAVL4_uc009vyu.2_Missense_Mutation_p.L255F|ELAVL4_uc010omz.1_Missense_Mutation_p.L255F	NM_021952	NP_068771	P26378	ELAV4_HUMAN	ELAV-like 4 isoform 1	250					mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			ovary(1)|pancreas(1)	2																		---	---	---	---
TTC39A	22996	broad.mit.edu	37	1	51771659	51771659	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:51771659G>A	uc001csl.2	-	7	791	c.686C>T	c.(685-687)GCC>GTC	p.A229V	TTC39A_uc001csk.2_Missense_Mutation_p.A194V|TTC39A_uc010ond.1_Missense_Mutation_p.A166V|TTC39A_uc010one.1_Missense_Mutation_p.A193V|TTC39A_uc010onf.1_Missense_Mutation_p.A197V|TTC39A_uc001csn.2_Missense_Mutation_p.A228V|TTC39A_uc001cso.1_Missense_Mutation_p.A225V|TTC39A_uc009vyy.1_Missense_Mutation_p.A166V	NM_001080494	NP_001073963	Q5SRH9	TT39A_HUMAN	tetratricopeptide repeat domain 39A isoform 2	229							binding			skin(1)	1																		---	---	---	---
OSBPL9	114883	broad.mit.edu	37	1	52179678	52179678	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:52179678G>A	uc001cst.2	+	4	264	c.245G>A	c.(244-246)CGT>CAT	p.R82H	OSBPL9_uc001css.2_Missense_Mutation_p.R100H|OSBPL9_uc001csx.2_RNA|OSBPL9_uc009vza.2_Missense_Mutation_p.R83H|OSBPL9_uc001csu.2_Missense_Mutation_p.R82H|OSBPL9_uc001csv.2_Translation_Start_Site|OSBPL9_uc001csw.2_Missense_Mutation_p.R82H	NM_024586	NP_078862	Q96SU4	OSBL9_HUMAN	oxysterol binding protein-like 9 isoform e	82	PH.				lipid transport		lipid binding			central_nervous_system(1)	1																		---	---	---	---
ORC1L	4998	broad.mit.edu	37	1	52861829	52861829	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:52861829G>T	uc001ctt.2	-	5	829	c.610C>A	c.(610-612)CCA>ACA	p.P204T	ORC1L_uc010oni.1_Missense_Mutation_p.P204T|ORC1L_uc001ctu.2_Missense_Mutation_p.P204T|ORC1L_uc009vzd.2_5'UTR	NM_004153	NP_004144	Q13415	ORC1_HUMAN	origin recognition complex, subunit 1	204					cell cycle checkpoint|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nuclear origin of replication recognition complex|nucleolus|nucleoplasm|plasma membrane	ATP binding|DNA binding|nucleoside-triphosphatase activity|protein binding				0																		---	---	---	---
LRRC42	115353	broad.mit.edu	37	1	54433549	54433549	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:54433549A>G	uc001cwj.1	+	8	1424	c.1224A>G	c.(1222-1224)CAA>CAG	p.Q408Q	LRRC42_uc001cwl.1_Silent_p.Q408Q|LRRC42_uc001cwk.1_Silent_p.Q408Q|LRRC42_uc009vzm.1_Silent_p.Q404Q	NM_052940	NP_443172	Q9Y546	LRC42_HUMAN	leucine rich repeat containing 42	408											0																		---	---	---	---
DHCR24	1718	broad.mit.edu	37	1	55337114	55337114	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:55337114T>C	uc001cyc.1	-	5	914	c.785A>G	c.(784-786)CAG>CGG	p.Q262R	DHCR24_uc010ooj.1_Missense_Mutation_p.Q124R|DHCR24_uc010ook.1_Missense_Mutation_p.Q221R	NM_014762	NP_055577	Q15392	DHC24_HUMAN	24-dehydrocholesterol reductase precursor	262					anti-apoptosis|apoptosis|cell cycle arrest|cholesterol biosynthetic process|negative regulation of caspase activity|neuroprotection|response to oxidative stress|skin development	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus	delta24-sterol reductase activity|enzyme binding|flavin adenine dinucleotide binding|peptide antigen binding			pancreas(1)	1																		---	---	---	---
USP24	23358	broad.mit.edu	37	1	55624658	55624658	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:55624658G>A	uc001cyg.3	-	9	784	c.784C>T	c.(784-786)CGC>TGC	p.R262C		NM_015306	NP_056121	Q9UPU5	UBP24_HUMAN	ubiquitin specific protease 24	374					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(6)|kidney(6)|breast(1)	13																		---	---	---	---
MYSM1	114803	broad.mit.edu	37	1	59126870	59126870	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:59126870C>T	uc009wab.1	-	19	2323	c.2300G>A	c.(2299-2301)CGG>CAG	p.R767Q	uc001cza.2_5'Flank|MYSM1_uc009waa.1_Missense_Mutation_p.R173Q|MYSM1_uc001czc.2_RNA	NM_001085487	NP_001078956	Q5VVJ2	MYSM1_HUMAN	Myb-like, SWIRM and MPN domains 1	767					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin remodeling complex	DNA binding|histone binding|metal ion binding|metallopeptidase activity|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(1)	1	all_cancers(7;9.36e-06)																	---	---	---	---
MIER1	57708	broad.mit.edu	37	1	67436605	67436605	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:67436605C>T	uc001dde.2	+	9	1021	c.887C>T	c.(886-888)GCA>GTA	p.A296V	MIER1_uc010opf.1_Missense_Mutation_p.A260V|MIER1_uc009way.2_Missense_Mutation_p.A260V|MIER1_uc001ddc.2_Missense_Mutation_p.A296V|MIER1_uc001ddh.2_Missense_Mutation_p.A180V|MIER1_uc001ddf.2_Missense_Mutation_p.A260V|MIER1_uc001ddg.2_Missense_Mutation_p.A216V|MIER1_uc010opg.1_Missense_Mutation_p.A260V|MIER1_uc001ddj.1_Missense_Mutation_p.A243V|MIER1_uc001ddi.2_Missense_Mutation_p.A243V	NM_001077700	NP_001071168	Q8N108	MIER1_HUMAN	mesoderm induction early response 1 isoform b	267	ELM2.|Interaction with HDAC1.				positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)	1																		---	---	---	---
PTGER3	5733	broad.mit.edu	37	1	71512898	71512898	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:71512898C>T	uc001dfg.1	-	1	594	c.363G>A	c.(361-363)GAG>GAA	p.E121E	PTGER3_uc001dfh.1_RNA|PTGER3_uc001dfi.1_RNA|PTGER3_uc001dfj.1_RNA|PTGER3_uc001dfk.1_Silent_p.E121E|PTGER3_uc001dfl.1_Silent_p.E121E|PTGER3_uc009wbm.1_Silent_p.E121E|PTGER3_uc001dfm.1_RNA|PTGER3_uc001dfn.2_Silent_p.E121E|PTGER3_uc009wbn.1_Silent_p.E121E|PTGER3_uc009wbo.2_Silent_p.E121E|PTGER3_uc001dfo.2_Silent_p.E121E|PTGER3_uc001dfp.1_Silent_p.E121E|PTGER3_uc001dfq.2_Silent_p.E121E|uc001dfr.2_RNA	NM_198714	NP_942007	P43115	PE2R3_HUMAN	prostaglandin E receptor 3, subtype EP3 isoform	121	Extracellular (Potential).				cell death|positive regulation of fever generation|transcription, DNA-dependent	integral to plasma membrane|nuclear envelope	ligand-dependent nuclear receptor activity|prostaglandin E receptor activity			pancreas(1)|lung(1)|skin(1)	3					Bimatoprost(DB00905)													---	---	---	---
SLC44A5	204962	broad.mit.edu	37	1	75693519	75693519	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:75693519A>G	uc001dgu.2	-	13	1021	c.877T>C	c.(877-879)TAC>CAC	p.Y293H	SLC44A5_uc001dgt.2_Missense_Mutation_p.Y293H|SLC44A5_uc001dgs.2_Missense_Mutation_p.Y251H|SLC44A5_uc001dgr.2_Missense_Mutation_p.Y251H|SLC44A5_uc010oqz.1_Missense_Mutation_p.Y332H|SLC44A5_uc010ora.1_Missense_Mutation_p.Y287H|SLC44A5_uc010orb.1_Missense_Mutation_p.Y163H	NM_152697	NP_689910	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5 isoform A	293	Extracellular (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			ovary(2)|skin(2)	4																		---	---	---	---
ELTD1	64123	broad.mit.edu	37	1	79383320	79383320	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:79383320A>G	uc001diq.3	-	12	1904	c.1748T>C	c.(1747-1749)CTT>CCT	p.L583P		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	583	Helical; Name=5; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)														---	---	---	---
ELTD1	64123	broad.mit.edu	37	1	79383329	79383329	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:79383329A>T	uc001diq.3	-	12	1895	c.1739T>A	c.(1738-1740)CTA>CAA	p.L580Q		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	580	Helical; Name=5; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)														---	---	---	---
CCBL2	56267	broad.mit.edu	37	1	89408688	89408688	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:89408688T>C	uc001dmp.2	-	13	1679	c.1302A>G	c.(1300-1302)AAA>AAG	p.K434K	CCBL2_uc001dmq.2_Silent_p.K400K|CCBL2_uc001dmr.2_Silent_p.K270K	NM_001008661	NP_001008661	Q6YP21	KAT3_HUMAN	kynurenine aminotransferase III isoform 1	434					biosynthetic process|kynurenine metabolic process|tryptophan catabolic process		cysteine-S-conjugate beta-lyase activity|kynurenine-glyoxylate transaminase activity|kynurenine-oxoglutarate transaminase activity|pyridoxal phosphate binding			ovary(1)	1		Lung NSC(277;0.123)		all cancers(265;0.0117)|Epithelial(280;0.0341)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)													---	---	---	---
GBP6	163351	broad.mit.edu	37	1	89851037	89851037	+	3'UTR	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:89851037T>C	uc001dnf.2	+	11					GBP6_uc010ost.1_3'UTR	NM_198460	NP_940862			guanylate binding protein family, member 6								GTP binding|GTPase activity			ovary(2)	2		Lung NSC(277;0.0908)		all cancers(265;0.0108)|Epithelial(280;0.0398)														---	---	---	---
LRRC8D	55144	broad.mit.edu	37	1	90399962	90399962	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:90399962A>G	uc001dnm.2	+	3	1760	c.1335A>G	c.(1333-1335)AAA>AAG	p.K445K	LRRC8D_uc001dnn.2_Silent_p.K445K	NM_001134479	NP_001127951	Q7L1W4	LRC8D_HUMAN	leucine rich repeat containing 8 family, member	445						integral to membrane	protein binding			ovary(2)	2		all_lung(203;0.0894)|Lung NSC(277;0.227)		all cancers(265;0.0109)|Epithelial(280;0.0427)														---	---	---	---
TGFBR3	7049	broad.mit.edu	37	1	92224190	92224190	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:92224190C>A	uc001doh.2	-	4	830	c.364G>T	c.(364-366)GGG>TGG	p.G122W	TGFBR3_uc009wde.2_5'UTR|TGFBR3_uc010osy.1_Missense_Mutation_p.G80W|TGFBR3_uc001doi.2_Missense_Mutation_p.G122W|TGFBR3_uc001doj.2_Missense_Mutation_p.G122W	NM_003243	NP_003234	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	122	Extracellular (Potential).				BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			ovary(3)	3		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)														---	---	---	---
MTF2	22823	broad.mit.edu	37	1	93602519	93602519	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:93602519C>T	uc009wdj.2	+	15	2009	c.1717C>T	c.(1717-1719)CGT>TGT	p.R573C	MTF2_uc010oth.1_Missense_Mutation_p.R471C|MTF2_uc009wdk.2_Missense_Mutation_p.R516C|MTF2_uc001dpi.3_Missense_Mutation_p.R300C|MTF2_uc010oti.1_Missense_Mutation_p.R471C|MTF2_uc001dpj.3_Missense_Mutation_p.R471C|MTF2_uc001dpl.3_Missense_Mutation_p.R471C|MTF2_uc001dpm.3_Missense_Mutation_p.R242C	NM_007358	NP_031384	Q9Y483	MTF2_HUMAN	metal response element binding transcription	573						nucleus	DNA binding|zinc ion binding			ovary(2)	2		all_lung(203;0.00196)|Lung NSC(277;0.00902)|Melanoma(281;0.099)|Ovarian(761;0.109)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00076)|GBM - Glioblastoma multiforme(16;0.00157)|Epithelial(280;0.0886)														---	---	---	---
GCLM	2730	broad.mit.edu	37	1	94360237	94360237	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:94360237C>T	uc001dqg.1	-	6	881	c.588G>A	c.(586-588)ATG>ATA	p.M196I		NM_002061	NP_002052	P48507	GSH0_HUMAN	glutamate-cysteine ligase regulatory protein	196					glutamate metabolic process|glutathione biosynthetic process|regulation of blood vessel size|response to drug|response to oxidative stress|xenobiotic metabolic process	cytosol|soluble fraction	glutamate-cysteine ligase catalytic subunit binding			ovary(1)	1		all_lung(203;0.000815)|Lung NSC(277;0.00363)		all cancers(265;0.00566)|GBM - Glioblastoma multiforme(16;0.0203)|Epithelial(280;0.131)	L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)													---	---	---	---
PTBP2	58155	broad.mit.edu	37	1	97250755	97250755	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:97250755A>G	uc001drq.2	+	8	1095	c.849A>G	c.(847-849)CAA>CAG	p.Q283Q	PTBP2_uc001drn.2_Silent_p.Q283Q|PTBP2_uc001dro.2_Silent_p.Q283Q|PTBP2_uc010otz.1_Silent_p.Q294Q|PTBP2_uc001drp.2_RNA|PTBP2_uc009wdw.2_Silent_p.Q231Q|PTBP2_uc001drr.2_Silent_p.Q283Q|PTBP2_uc010oua.1_Silent_p.Q291Q|PTBP2_uc001dru.2_RNA|PTBP2_uc001drs.1_5'UTR|PTBP2_uc001drt.2_5'UTR	NM_021190	NP_067013	Q9UKA9	PTBP2_HUMAN	polypyrimidine tract binding protein 2	283							nucleotide binding				0		all_epithelial(167;2.95e-05)|all_lung(203;0.000396)|Lung NSC(277;0.00171)		all cancers(265;0.0582)|Epithelial(280;0.0716)|Colorectal(170;0.0879)|KIRC - Kidney renal clear cell carcinoma(1967;0.202)														---	---	---	---
DBT	1629	broad.mit.edu	37	1	100676315	100676315	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:100676315C>A	uc001dta.2	-	8	985	c.952G>T	c.(952-954)GGA>TGA	p.G318*	DBT_uc010oug.1_Nonsense_Mutation_p.G137*	NM_001918	NP_001909	P11182	ODB2_HUMAN	dihydrolipoamide branched chain transacylase	318					branched chain family amino acid catabolic process|fatty-acyl-CoA biosynthetic process	microtubule cytoskeleton|mitochondrial alpha-ketoglutarate dehydrogenase complex|mitochondrial nucleoid	acyltransferase activity|cofactor binding|dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity|protein binding			pancreas(1)	1		all_epithelial(167;5.4e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0739)|all cancers(265;0.123)|COAD - Colon adenocarcinoma(174;0.154)|Lung(183;0.199)														---	---	---	---
DPH5	51611	broad.mit.edu	37	1	101487198	101487198	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:101487198C>A	uc001dts.2	-	3	406	c.259G>T	c.(259-261)GGG>TGG	p.G87W	DPH5_uc001dtr.2_Missense_Mutation_p.G87W|DPH5_uc001dtq.2_RNA|DPH5_uc001dtt.2_Missense_Mutation_p.G87W|DPH5_uc001dtu.2_RNA|DPH5_uc001dtv.2_RNA|DPH5_uc001dtw.2_RNA|DPH5_uc001dtx.2_Missense_Mutation_p.G87W|DPH5_uc001dty.2_Missense_Mutation_p.L16F|DPH5_uc001dtz.2_RNA	NM_015958	NP_057042	Q9H2P9	DPH5_HUMAN	diphthine synthase isoform a	87		S-adenosyl-L-methionine; via carbonyl oxygen (By similarity).			peptidyl-diphthamide biosynthetic process from peptidyl-histidine		diphthine synthase activity				0		all_epithelial(167;3.1e-06)|all_lung(203;0.000414)|Lung NSC(277;0.000946)		Epithelial(280;0.0385)|all cancers(265;0.043)|COAD - Colon adenocarcinoma(174;0.151)|Colorectal(144;0.173)|Lung(183;0.198)														---	---	---	---
NTNG1	22854	broad.mit.edu	37	1	107961230	107961230	+	Intron	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:107961230G>A	uc001dvh.3	+						NTNG1_uc001dvf.3_Silent_p.P372P|NTNG1_uc010out.1_Silent_p.P372P|NTNG1_uc001dvc.3_Intron|NTNG1_uc001dvi.2_Intron|NTNG1_uc001dve.2_RNA|NTNG1_uc009wek.2_RNA|NTNG1_uc001dvg.2_RNA|NTNG1_uc009wem.2_Intron	NM_001113226	NP_001106697			netrin G1 isoform 1						axonogenesis	anchored to plasma membrane	protein binding			large_intestine(2)|ovary(2)|skin(2)	6		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)														---	---	---	---
WDR47	22911	broad.mit.edu	37	1	109525279	109525279	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:109525279T>C	uc001dwj.2	-	12	2594	c.2218A>G	c.(2218-2220)ACC>GCC	p.T740A	WDR47_uc001dwl.2_Missense_Mutation_p.T748A|WDR47_uc001dwi.2_Missense_Mutation_p.T741A|WDR47_uc010ovf.1_Missense_Mutation_p.T665A	NM_001142551	NP_001136023	O94967	WDR47_HUMAN	WD repeat domain 47 isoform 3	740	WD 3.									ovary(1)	1		all_lung(203;0.00519)|all_epithelial(167;0.00611)|Lung NSC(277;0.00822)		Colorectal(144;0.0165)|Lung(183;0.0484)|COAD - Colon adenocarcinoma(174;0.128)|Epithelial(280;0.168)|all cancers(265;0.201)|LUSC - Lung squamous cell carcinoma(189;0.244)														---	---	---	---
FAM40A	85369	broad.mit.edu	37	1	110592070	110592070	+	Intron	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:110592070T>C	uc001dza.1	+						FAM40A_uc001dyz.1_Intron|FAM40A_uc009wfp.1_Intron	NM_033088	NP_149079			hypothetical protein LOC85369							nucleus	protein binding			ovary(3)|large_intestine(1)	4		all_cancers(81;8.51e-05)|all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0154)|all cancers(265;0.0732)|Epithelial(280;0.0781)|Colorectal(144;0.115)|LUSC - Lung squamous cell carcinoma(189;0.137)														---	---	---	---
SIKE1	80143	broad.mit.edu	37	1	115322723	115322723	+	Intron	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:115322723T>C	uc001efo.3	-						SIKE1_uc001efp.3_Intron	NM_025073	NP_079349			suppressor of IKK epsilon isoform 2							cytosol	protein binding				0																		---	---	---	---
LIX1L	128077	broad.mit.edu	37	1	145487432	145487432	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:145487432A>G	uc001enr.2	+	2	495	c.421A>G	c.(421-423)ACC>GCC	p.T141A	NBPF10_uc001emp.3_Intron	NM_153713	NP_714924	Q8IVB5	LIX1L_HUMAN	Lix1 homolog (mouse) like	141										ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)																	---	---	---	---
NUDT17	200035	broad.mit.edu	37	1	145588461	145588461	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:145588461C>A	uc001eoe.2	-	4	420	c.412G>T	c.(412-414)GGA>TGA	p.G138*	NBPF10_uc001emp.3_Intron	NM_001012758	NP_001012776	P0C025	NUD17_HUMAN	nudix (nucleoside diphosphate linked moiety	138	Nudix box.|Nudix hydrolase.						hydrolase activity|metal ion binding				0	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)															OREG0013751	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
POLR3C	10623	broad.mit.edu	37	1	145606365	145606365	+	Splice_Site	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:145606365T>C	uc001eoh.2	-	5	751	c.590_splice	c.e5-1	p.G197_splice	NBPF10_uc001emp.3_Intron|POLR3C_uc001eog.2_Splice_Site_p.G210_splice|POLR3C_uc001eoi.2_Splice_Site|POLR3C_uc009wix.2_Splice_Site_p.G197_splice	NM_006468	NP_006459			polymerase (RNA) III (DNA directed) polypeptide						innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|regulation of transcription from RNA polymerase III promoter|response to virus	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity			ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)		Epithelial(2;7.55e-13)															---	---	---	---
SETDB1	9869	broad.mit.edu	37	1	150923206	150923206	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:150923206A>G	uc001evu.2	+	13	2043	c.1853A>G	c.(1852-1854)AAC>AGC	p.N618S	SETDB1_uc009wmf.2_Missense_Mutation_p.N619S|SETDB1_uc001evv.2_Missense_Mutation_p.N618S|SETDB1_uc009wmg.1_Missense_Mutation_p.N618S	NM_001145415	NP_001138887	Q15047	SETB1_HUMAN	SET domain, bifurcated 1 isoform 1	618	MBD.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)															---	---	---	---
TCHH	7062	broad.mit.edu	37	1	152081227	152081227	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:152081227T>C	uc001ezp.2	-	2	4466	c.4466A>G	c.(4465-4467)GAG>GGG	p.E1489G	TCHH_uc009wne.1_Missense_Mutation_p.E1489G	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1489	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)															---	---	---	---
HRNR	388697	broad.mit.edu	37	1	152188012	152188012	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:152188012T>C	uc001ezt.1	-	3	6169	c.6093A>G	c.(6091-6093)CAA>CAG	p.Q2031Q		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2031	22.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)															---	---	---	---
HRNR	388697	broad.mit.edu	37	1	152192230	152192230	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:152192230T>C	uc001ezt.1	-	3	1951	c.1875A>G	c.(1873-1875)CAA>CAG	p.Q625Q		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	625	6.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)															---	---	---	---
HRNR	388697	broad.mit.edu	37	1	152192934	152192934	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:152192934C>A	uc001ezt.1	-	3	1247	c.1171G>T	c.(1171-1173)GGC>TGC	p.G391C		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	391	4.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)															---	---	---	---
FLG2	388698	broad.mit.edu	37	1	152326514	152326514	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:152326514T>C	uc001ezw.3	-	3	3821	c.3748A>G	c.(3748-3750)AGC>GGC	p.S1250G	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1250	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)															---	---	---	---
LCE5A	254910	broad.mit.edu	37	1	152484072	152484072	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:152484072C>A	uc001ezy.2	+	2	238	c.62C>A	c.(61-63)CCT>CAT	p.P21H	CRCT1_uc001ezz.2_5'Flank	NM_178438	NP_848525	Q5TCM9	LCE5A_HUMAN	late cornified envelope 5A	21	Cys-rich.				keratinization					ovary(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)															---	---	---	---
IVL	3713	broad.mit.edu	37	1	152882474	152882474	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:152882474A>G	uc001fau.2	+	2	247	c.201A>G	c.(199-201)GTA>GTG	p.V67V		NM_005547	NP_005538	P07476	INVO_HUMAN	involucrin	67					isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine|keratinization|response to UV-B	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			ovary(3)	3	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)															---	---	---	---
NPR1	4881	broad.mit.edu	37	1	153657446	153657446	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:153657446G>A	uc001fcs.3	+	8	1912	c.1491G>A	c.(1489-1491)ATG>ATA	p.M497I	NPR1_uc010pdz.1_Missense_Mutation_p.M243I|NPR1_uc010pea.1_Missense_Mutation_p.M1I	NM_000906	NP_000897	P16066	ANPRA_HUMAN	natriuretic peptide receptor 1 precursor	497	Cytoplasmic (Potential).				body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			ovary(3)|lung(2)|stomach(1)|breast(1)	7	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)													---	---	---	---
CREB3L4	148327	broad.mit.edu	37	1	153946445	153946445	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:153946445T>C	uc001fdn.3	+	10	1358	c.1092T>C	c.(1090-1092)GAT>GAC	p.D364D	CREB3L4_uc010pef.1_Silent_p.D217D|CREB3L4_uc001fdo.3_Silent_p.D344D|CREB3L4_uc001fdm.1_Silent_p.D364D|CREB3L4_uc001fdp.1_Silent_p.D344D|CREB3L4_uc001fdr.2_Silent_p.D364D|CREB3L4_uc001fdq.2_Silent_p.D344D	NM_130898	NP_570968	Q8TEY5	CR3L4_HUMAN	cAMP responsive element binding protein 3-like	364	Lumenal (Potential).				response to unfolded protein	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)															---	---	---	---
NUP210L	91181	broad.mit.edu	37	1	154112412	154112412	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:154112412C>T	uc001fdw.2	-	5	655	c.583G>A	c.(583-585)GAA>AAA	p.E195K	NUP210L_uc010peh.1_Missense_Mutation_p.E195K	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	195						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)															---	---	---	---
UBAP2L	9898	broad.mit.edu	37	1	154239006	154239006	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:154239006G>A	uc001fep.3	+	25	3099	c.2932G>A	c.(2932-2934)GTG>ATG	p.V978M	UBAP2L_uc010pel.1_Missense_Mutation_p.V988M|UBAP2L_uc001feq.2_Missense_Mutation_p.V174M|UBAP2L_uc001fer.2_Missense_Mutation_p.V174M	NM_014847	NP_055662	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like isoform a	978					binding of sperm to zona pellucida		protein binding			ovary(1)|central_nervous_system(1)	2	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)															---	---	---	---
ADAR	103	broad.mit.edu	37	1	154569705	154569705	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:154569705G>T	uc001ffh.2	-	5	2173	c.1973C>A	c.(1972-1974)CCC>CAC	p.P658H	ADAR_uc001ffj.2_Missense_Mutation_p.P658H|ADAR_uc001ffi.2_Missense_Mutation_p.P658H|ADAR_uc001ffk.2_Missense_Mutation_p.P363H	NM_001111	NP_001102	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific isoform a	658	DRBM 2.				adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)														---	---	---	---
DCST1	149095	broad.mit.edu	37	1	155020285	155020285	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:155020285C>T	uc001fgn.1	+	15	1731	c.1635C>T	c.(1633-1635)GGC>GGT	p.G545G	DCST1_uc010pes.1_Silent_p.G520G|uc001fgo.2_Intron	NM_152494	NP_689707	Q5T197	DCST1_HUMAN	DC-STAMP domain containing 1 isoform 1	545	Extracellular (Potential).					integral to membrane	zinc ion binding			ovary(1)|skin(1)	2	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)															---	---	---	---
TRIM46	80128	broad.mit.edu	37	1	155154563	155154563	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:155154563C>T	uc001fhs.1	+	9	1907	c.1824C>T	c.(1822-1824)GGC>GGT	p.G608G	RAG1AP1_uc010pey.1_Intron|TRIM46_uc009wpe.1_RNA|TRIM46_uc001fht.1_RNA|TRIM46_uc010pfa.1_Silent_p.G482G|TRIM46_uc001fhu.1_Silent_p.G585G|TRIM46_uc009wpg.1_Silent_p.G595G|TRIM46_uc001fhw.1_RNA	NM_025058	NP_079334	Q7Z4K8	TRI46_HUMAN	tripartite motif-containing 46	608	B30.2/SPRY.					intracellular	zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;6.62e-10)|all cancers(21;2.68e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)															---	---	---	---
HCN3	57657	broad.mit.edu	37	1	155252506	155252506	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:155252506C>T	uc001fjz.1	+	2	591	c.583C>T	c.(583-585)CGG>TGG	p.R195W	RAG1AP1_uc010pey.1_Intron|HCN3_uc010pfz.1_Translation_Start_Site	NM_020897	NP_065948	Q9P1Z3	HCN3_HUMAN	hyperpolarization activated cyclic	195	Extracellular (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)|breast(1)	2	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)															---	---	---	---
FDPS	2224	broad.mit.edu	37	1	155282155	155282155	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:155282155G>A	uc001fkc.2	+	4	668	c.449G>A	c.(448-450)CGG>CAG	p.R150Q	RAG1AP1_uc010pey.1_Intron|FDPS_uc001fkd.2_Missense_Mutation_p.R84Q|FDPS_uc001fke.2_Missense_Mutation_p.R150Q|FDPS_uc001fkf.2_Missense_Mutation_p.R84Q	NM_002004	NP_001995	P14324	FPPS_HUMAN	farnesyl diphosphate synthase isoform a	150					cholesterol biosynthetic process|interspecies interaction between organisms|isoprenoid biosynthetic process	cytosol|nucleus	dimethylallyltranstransferase activity|geranyltranstransferase activity|metal ion binding				0	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;2.03e-10)|all cancers(21;5.23e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)		Alendronate(DB00630)|Ibandronate(DB00710)|Pamidronate(DB00282)|Risedronate(DB00884)|Zoledronate(DB00399)													---	---	---	---
ASH1L	55870	broad.mit.edu	37	1	155448724	155448724	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:155448724G>T	uc009wqq.2	-	3	4417	c.3937C>A	c.(3937-3939)CGA>AGA	p.R1313R	ASH1L_uc001fkt.2_Silent_p.R1313R|ASH1L_uc009wqr.1_Silent_p.R1313R	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	1313					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)															---	---	---	---
ASH1L	55870	broad.mit.edu	37	1	155451338	155451338	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:155451338A>G	uc009wqq.2	-	3	1803	c.1323T>C	c.(1321-1323)AGT>AGC	p.S441S	ASH1L_uc001fkt.2_Silent_p.S441S|ASH1L_uc009wqr.1_Silent_p.S441S	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	441					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)															---	---	---	---
LMNA	4000	broad.mit.edu	37	1	156105025	156105025	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156105025G>A	uc001fni.2	+	5	1107	c.858G>A	c.(856-858)GGG>GGA	p.G286G	LMNA_uc001fnf.1_Silent_p.G286G|LMNA_uc001fng.2_Silent_p.G286G|LMNA_uc001fnh.2_Silent_p.G286G|LMNA_uc009wro.1_Silent_p.G286G|LMNA_uc010pgz.1_Silent_p.G174G|LMNA_uc001fnj.2_Silent_p.G205G|LMNA_uc001fnk.2_Silent_p.G187G|LMNA_uc009wrp.2_Missense_Mutation_p.G14E|LMNA_uc010pha.1_5'Flank	NM_170707	NP_733821	P02545	LMNA_HUMAN	lamin A/C isoform 1 precursor	286	Coil 2.|Rod.				cellular component disassembly involved in apoptosis|cellular response to hypoxia|establishment or maintenance of microtubule cytoskeleton polarity|muscle organ development|positive regulation of cell aging|regulation of apoptosis|regulation of cell migration	cytoplasm|lamin filament|nuclear envelope|nuclear envelope|perinuclear region of cytoplasm	protein binding|structural molecule activity|structural molecule activity			ovary(2)	2	Hepatocellular(266;0.158)													Werner_syndrome|Hutchinson-Gilford_Progeria_Syndrome				---	---	---	---
SMG5	23381	broad.mit.edu	37	1	156235734	156235734	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156235734T>G	uc001foc.3	-	12	1842	c.1693A>C	c.(1693-1695)AGC>CGC	p.S565R	SMG5_uc009wrv.2_Missense_Mutation_p.S50R	NM_015327	NP_056142	Q9UPR3	SMG5_HUMAN	SMG5 homolog nonsense mediated mRNA decay	565					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			ovary(2)|skin(2)|pancreas(1)	5	Hepatocellular(266;0.158)																	---	---	---	---
NES	10763	broad.mit.edu	37	1	156642747	156642747	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156642747A>G	uc001fpq.2	-	4	1366	c.1233T>C	c.(1231-1233)CCT>CCC	p.P411P		NM_006617	NP_006608	P48681	NEST_HUMAN	nestin	411	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)																	---	---	---	---
SH2D2A	9047	broad.mit.edu	37	1	156779193	156779193	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156779193G>A	uc001fqd.2	-	7	944	c.804C>T	c.(802-804)CGC>CGT	p.R268R	SH2D2A_uc001fqc.1_Silent_p.R240R|SH2D2A_uc009wsh.2_Silent_p.R278R|SH2D2A_uc001fqe.2_Silent_p.R250R|SH2D2A_uc010phs.1_Silent_p.R268R	NM_003975	NP_003966	Q9NP31	SH22A_HUMAN	SH2 domain protein 2A isoform 2	268	Pro-rich.				angiogenesis|cell differentiation|signal transduction	cytoplasm|soluble fraction	SH3 domain binding|SH3/SH2 adaptor activity				0	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)																	---	---	---	---
INSRR	3645	broad.mit.edu	37	1	156816356	156816356	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156816356G>A	uc010pht.1	-	8	2019	c.1765C>T	c.(1765-1767)CAA>TAA	p.Q589*	NTRK1_uc001fqf.1_Intron|NTRK1_uc009wsi.1_Intron	NM_014215	NP_055030	P14616	INSRR_HUMAN	insulin receptor-related receptor precursor	589	Fibronectin type-III 1.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			lung(11)|ovary(5)|skin(2)|kidney(1)|central_nervous_system(1)	20	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)																	---	---	---	---
CD1D	912	broad.mit.edu	37	1	158152042	158152042	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:158152042C>T	uc001frr.2	+	4	1048	c.549C>T	c.(547-549)ACC>ACT	p.T183T	CD1D_uc009wsr.1_Silent_p.T183T|CD1D_uc009wss.2_Silent_p.T183T|CD1D_uc009wst.1_Silent_p.T79T	NM_001766	NP_001757	P15813	CD1D_HUMAN	CD1D antigen precursor	183	Extracellular (Potential).				antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			ovary(1)	1	all_hematologic(112;0.0378)																	---	---	---	---
CD1A	909	broad.mit.edu	37	1	158226686	158226686	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:158226686C>T	uc001frt.2	+	4	1248	c.715C>T	c.(715-717)CGG>TGG	p.R239W		NM_001763	NP_001754	P06126	CD1A_HUMAN	CD1A antigen precursor	239	Extracellular (Potential).|Ig-like.				antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)													---	---	---	---
CD1B	910	broad.mit.edu	37	1	158299763	158299763	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:158299763G>T	uc001frx.2	-	3	594	c.486C>A	c.(484-486)TTC>TTA	p.F162L	CD1B_uc001frw.2_Missense_Mutation_p.F55L	NM_001764	NP_001755	P29016	CD1B_HUMAN	CD1B antigen precursor	162	Extracellular (Potential).				antigen processing and presentation|immune response	endosome membrane|integral to membrane|lysosomal membrane|plasma membrane	protein binding			ovary(2)	2	all_hematologic(112;0.0378)																	---	---	---	---
CD1E	913	broad.mit.edu	37	1	158325868	158325868	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:158325868G>A	uc001fse.2	+	4	1116	c.877G>A	c.(877-879)GGG>AGG	p.G293R	CD1E_uc010pid.1_Missense_Mutation_p.G291R|CD1E_uc010pie.1_Missense_Mutation_p.G194R|CD1E_uc010pif.1_Missense_Mutation_p.G104R|CD1E_uc001fsd.2_Intron|CD1E_uc001fsk.2_Missense_Mutation_p.G203R|CD1E_uc001fsj.2_Intron|CD1E_uc001fsc.2_Missense_Mutation_p.G104R|CD1E_uc010pig.1_Intron|CD1E_uc001fsa.2_Intron|CD1E_uc001fsf.2_Missense_Mutation_p.G293R|CD1E_uc001fry.2_Intron|CD1E_uc001fsg.2_Intron|CD1E_uc001fsh.2_Missense_Mutation_p.G104R|CD1E_uc001fsi.2_Intron|CD1E_uc009wsv.2_Missense_Mutation_p.G194R|CD1E_uc001frz.2_Missense_Mutation_p.G203R|CD1E_uc009wsw.2_Missense_Mutation_p.G51R	NM_030893	NP_112155	P15812	CD1E_HUMAN	CD1E antigen isoform a precursor	293	Ig-like.				antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				skin(3)	3	all_hematologic(112;0.0378)																	---	---	---	---
SPTA1	6708	broad.mit.edu	37	1	158581162	158581162	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:158581162T>G	uc001fst.1	-	52	7351	c.7152A>C	c.(7150-7152)CAA>CAC	p.Q2384H		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	2384	EF-hand 3.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)																	---	---	---	---
OR6K3	391114	broad.mit.edu	37	1	158687251	158687251	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:158687251T>C	uc010pip.1	-	1	703	c.703A>G	c.(703-705)AGA>GGA	p.R235G		NM_001005327	NP_001005327	Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K,	235	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(112;0.0378)																	---	---	---	---
IGSF9	57549	broad.mit.edu	37	1	159900941	159900941	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:159900941A>G	uc001fur.2	-	13	1822	c.1624T>C	c.(1624-1626)TGG>CGG	p.W542R	IGSF9_uc001fuq.2_Missense_Mutation_p.W526R|IGSF9_uc001fup.2_5'UTR	NM_001135050	NP_001128522	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9 isoform a	542	Fibronectin type-III 1.|Extracellular (Potential).					cell junction|integral to membrane|synapse				ovary(2)|central_nervous_system(2)|large_intestine(1)	5	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)															---	---	---	---
PIGM	93183	broad.mit.edu	37	1	160001186	160001186	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:160001186A>G	uc001fuv.1	-	1	598	c.344T>C	c.(343-345)CTG>CCG	p.L115P		NM_145167	NP_660150	Q9H3S5	PIGM_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	115	Cytoplasmic (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane				ovary(2)|skin(1)	3	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)															---	---	---	---
NOS1AP	9722	broad.mit.edu	37	1	162325131	162325131	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:162325131C>T	uc001gbv.2	+	7	1137	c.750C>T	c.(748-750)CAC>CAT	p.H250H	NOS1AP_uc010pkr.1_Silent_p.H245H|NOS1AP_uc010pks.1_RNA|NOS1AP_uc001gbw.2_Silent_p.H245H	NM_014697	NP_055512	O75052	CAPON_HUMAN	nitric oxide synthase 1 (neuronal) adaptor	250					regulation of apoptosis|regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity		nitric-oxide synthase binding|PDZ domain binding			lung(2)|upper_aerodigestive_tract(1)	3	all_hematologic(112;0.203)		BRCA - Breast invasive adenocarcinoma(70;0.0537)															---	---	---	---
UCK2	7371	broad.mit.edu	37	1	165876941	165876941	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:165876941C>T	uc001gdp.2	+	7	848	c.667C>T	c.(667-669)CAG>TAG	p.Q223*	UCK2_uc010plb.1_Nonsense_Mutation_p.Q85*	NM_012474	NP_036606	Q9BZX2	UCK2_HUMAN	uridine-cytidine kinase 2	223					pyrimidine base metabolic process|pyrimidine nucleoside salvage	cytosol	ATP binding|phosphotransferase activity, alcohol group as acceptor|uridine kinase activity			ovary(1)	1	all_hematologic(923;0.048)|Acute lymphoblastic leukemia(8;0.155)																	---	---	---	---
MAEL	84944	broad.mit.edu	37	1	166958612	166958612	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:166958612G>A	uc001gdy.1	+	1	94	c.23G>A	c.(22-24)CGG>CAG	p.R8Q	MAEL_uc001gdz.1_Missense_Mutation_p.R8Q|MAEL_uc009wvf.1_5'Flank	NM_032858	NP_116247	Q96JY0	MAEL_HUMAN	maelstrom homolog	8	HMG box.				cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			skin(1)	1																		---	---	---	---
TBX19	9095	broad.mit.edu	37	1	168262376	168262376	+	Intron	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:168262376C>T	uc001gfl.2	+						TBX19_uc001gfj.3_Intron	NM_005149	NP_005140			T-box 19						anatomical structure morphogenesis	nucleus	DNA binding				0	all_hematologic(923;0.215)																	---	---	---	---
METTL13	51603	broad.mit.edu	37	1	171753504	171753504	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:171753504C>T	uc001ghz.2	+	2	1125	c.778C>T	c.(778-780)CGC>TGC	p.R260C	METTL13_uc001gia.2_Missense_Mutation_p.R174C|METTL13_uc001gib.2_Intron|METTL13_uc010pml.1_Missense_Mutation_p.R259C	NM_015935	NP_057019	Q8N6R0	MTL13_HUMAN	CGI-01 protein isoform 1	260							methyltransferase activity|protein binding			kidney(1)	1																		---	---	---	---
KLHL20	27252	broad.mit.edu	37	1	173702865	173702865	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:173702865C>T	uc001gjc.2	+	3	216	c.37C>T	c.(37-39)CGA>TGA	p.R13*	KLHL20_uc010pmr.1_Intron|KLHL20_uc009wwf.2_5'UTR|KLHL20_uc001gjd.2_Nonsense_Mutation_p.R13*	NM_014458	NP_055273	Q9Y2M5	KLH20_HUMAN	kelch-like 20	13					cytoskeleton organization|negative regulation of apoptosis|proteasomal ubiquitin-dependent protein catabolic process|response to interferon-alpha	actin cytoskeleton|cell surface|Cul3-RING ubiquitin ligase complex|Golgi apparatus|perinuclear region of cytoplasm|PML body	actin binding|interferon-gamma binding|ubiquitin-protein ligase activity			ovary(1)	1																		---	---	---	---
KLHL20	27252	broad.mit.edu	37	1	173735385	173735385	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:173735385G>A	uc001gjc.2	+	8	1431	c.1252G>A	c.(1252-1254)GTG>ATG	p.V418M	KLHL20_uc010pmr.1_Missense_Mutation_p.V229M|KLHL20_uc009wwf.2_Missense_Mutation_p.V400M	NM_014458	NP_055273	Q9Y2M5	KLH20_HUMAN	kelch-like 20	418	Kelch 3.				cytoskeleton organization|negative regulation of apoptosis|proteasomal ubiquitin-dependent protein catabolic process|response to interferon-alpha	actin cytoskeleton|cell surface|Cul3-RING ubiquitin ligase complex|Golgi apparatus|perinuclear region of cytoplasm|PML body	actin binding|interferon-gamma binding|ubiquitin-protein ligase activity			ovary(1)	1																		---	---	---	---
GPR52	9293	broad.mit.edu	37	1	174417458	174417458	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:174417458T>C	uc001gka.1	+	1	247	c.209T>C	c.(208-210)CTG>CCG	p.L70P	RABGAP1L_uc001gjw.2_Intron|RABGAP1L_uc001gjx.2_Intron|RABGAP1L_uc001gjy.2_Intron|RABGAP1L_uc001gjz.2_Intron	NM_005684	NP_005675	Q9Y2T5	GPR52_HUMAN	G protein-coupled receptor 52	70	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			skin(1)	1																		---	---	---	---
TNR	7143	broad.mit.edu	37	1	175372584	175372584	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:175372584C>T	uc001gkp.1	-	2	749	c.668G>A	c.(667-669)AGC>AAC	p.S223N	TNR_uc009wwu.1_Missense_Mutation_p.S223N|TNR_uc010pmz.1_Missense_Mutation_p.S223N	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	223	Cys-rich.|EGF-like 2.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix		p.S223S(1)		pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)																	---	---	---	---
RFWD2	64326	broad.mit.edu	37	1	175996767	175996767	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:175996767T>C	uc001gku.1	-	15	1926	c.1670A>G	c.(1669-1671)AAT>AGT	p.N557S	RFWD2_uc001gkv.1_Missense_Mutation_p.N533S|RFWD2_uc001gkw.1_Missense_Mutation_p.N317S|RFWD2_uc009wwv.2_Missense_Mutation_p.N356S|RFWD2_uc001gkt.1_Missense_Mutation_p.N396S	NM_022457	NP_071902	Q8NHY2	RFWD2_HUMAN	ring finger and WD repeat domain 2 isoform a	557	WD 4.				DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	centrosome|cytosol|focal adhesion|nuclear speck	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0																		---	---	---	---
RFWD2	64326	broad.mit.edu	37	1	176012905	176012905	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:176012905A>G	uc001gku.1	-	13	1727	c.1471T>C	c.(1471-1473)TAT>CAT	p.Y491H	RFWD2_uc001gkv.1_Missense_Mutation_p.Y467H|RFWD2_uc001gkw.1_Missense_Mutation_p.Y251H|RFWD2_uc009wwv.2_Missense_Mutation_p.Y290H|RFWD2_uc001gkt.1_Missense_Mutation_p.Y330H	NM_022457	NP_071902	Q8NHY2	RFWD2_HUMAN	ring finger and WD repeat domain 2 isoform a	491	WD 2.				DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	centrosome|cytosol|focal adhesion|nuclear speck	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0																		---	---	---	---
CACNA1E	777	broad.mit.edu	37	1	181686388	181686388	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:181686388G>A	uc001gow.2	+	11	1640	c.1475G>A	c.(1474-1476)TGT>TAT	p.C492Y	CACNA1E_uc009wxs.2_Missense_Mutation_p.C399Y	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	492	Helical; Name=S1 of repeat II.|II.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6																		---	---	---	---
HMCN1	83872	broad.mit.edu	37	1	186107029	186107029	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:186107029T>A	uc001grq.1	+	89	14078	c.13849T>A	c.(13849-13851)TCA>ACA	p.S4617T	HMCN1_uc001grs.1_Missense_Mutation_p.S186T	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4617	TSP type-1 2.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23																		---	---	---	---
TPR	7175	broad.mit.edu	37	1	186325579	186325579	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:186325579A>G	uc001grv.2	-	15	2024	c.1727T>C	c.(1726-1728)ATC>ACC	p.I576T		NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	576	Potential.				carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)				T	NTRK1	papillary thyroid								---	---	---	---
PLA2G4A	5321	broad.mit.edu	37	1	186901899	186901899	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:186901899C>A	uc001gsc.2	+	8	768	c.563C>A	c.(562-564)CCT>CAT	p.P188H	PLA2G4A_uc010pos.1_Missense_Mutation_p.P128H	NM_024420	NP_077734	P47712	PA24A_HUMAN	cytosolic phospholipase A2, group IVA	188	PLA2c.				phospholipid catabolic process|platelet activating factor biosynthetic process|platelet activation	cytosol|endoplasmic reticulum membrane	calcium ion binding|calcium-dependent phospholipid binding|lysophospholipase activity			lung(2)|breast(1)	3					Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Medrysone(DB00253)|Quinacrine(DB01103)													---	---	---	---
CRB1	23418	broad.mit.edu	37	1	197390889	197390889	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:197390889A>G	uc001gtz.2	+	6	2066	c.1931A>G	c.(1930-1932)CAA>CGA	p.Q644R	CRB1_uc010poz.1_Missense_Mutation_p.Q575R|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.Q532R|CRB1_uc010ppb.1_Missense_Mutation_p.Q644R|CRB1_uc010ppc.1_RNA|CRB1_uc010ppd.1_Missense_Mutation_p.Q125R|CRB1_uc001gub.1_Missense_Mutation_p.Q293R	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	644	Extracellular (Potential).|Laminin G-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9																		---	---	---	---
KIF21B	23046	broad.mit.edu	37	1	200977992	200977992	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:200977992C>T	uc001gvs.1	-	3	669	c.352G>A	c.(352-354)GCA>ACA	p.A118T	KIF21B_uc001gvr.1_Missense_Mutation_p.A118T|KIF21B_uc009wzl.1_Missense_Mutation_p.A118T|KIF21B_uc010ppn.1_Missense_Mutation_p.A118T	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	118	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6																		---	---	---	---
ARL8A	127829	broad.mit.edu	37	1	202107101	202107101	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:202107101G>A	uc001gxk.1	-	3	436	c.270C>T	c.(268-270)AGC>AGT	p.S90S		NM_138795	NP_620150	Q96BM9	ARL8A_HUMAN	ADP-ribosylation factor-like 8A	90					cell division|chromosome segregation|mitosis|small GTPase mediated signal transduction	late endosome membrane|lysosomal membrane|midbody|spindle midzone	alpha-tubulin binding|beta-tubulin binding|GTP binding|GTPase activity			ovary(2)	2																		---	---	---	---
PTPN7	5778	broad.mit.edu	37	1	202121666	202121666	+	Intron	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:202121666G>A	uc001gxm.1	-						PTPN7_uc001gxl.1_Intron|PTPN7_uc001gxn.1_Intron|PTPN7_uc010ppv.1_Intron|PTPN7_uc010ppw.1_Intron|PTPN7_uc010ppx.1_Intron|PTPN7_uc010ppy.1_Intron|PTPN7_uc001gxo.1_Intron	NM_002832	NP_002823			protein tyrosine phosphatase, non-receptor type							cytosol|internal side of plasma membrane	protein binding|protein tyrosine phosphatase activity			skin(1)	1																		---	---	---	---
PPP1R12B	4660	broad.mit.edu	37	1	202407084	202407084	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:202407084C>A	uc001gya.1	+	10	1534	c.1390C>A	c.(1390-1392)CGA>AGA	p.R464R	PPP1R12B_uc001gxy.2_Silent_p.R464R|PPP1R12B_uc009xad.1_Silent_p.R270R|PPP1R12B_uc009xae.1_3'UTR|PPP1R12B_uc001gxz.1_Silent_p.R464R	NM_002481	NP_002472	O60237	MYPT2_HUMAN	protein phosphatase 1, regulatory (inhibitor)	464					regulation of muscle contraction|signal transduction	cytoplasm	enzyme activator activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(75;0.166)															---	---	---	---
PPFIA4	8497	broad.mit.edu	37	1	203015058	203015058	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:203015058T>C	uc009xaj.2	+	12	1389	c.1389T>C	c.(1387-1389)CAT>CAC	p.H463H	PPFIA4_uc010pqf.1_Silent_p.H23H			O75335	LIPA4_HUMAN	SubName: Full=Liprin alpha4;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell communication	cell surface|cytoplasm	protein binding			ovary(4)|skin(1)	5																		---	---	---	---
CHI3L1	1116	broad.mit.edu	37	1	203152803	203152803	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:203152803C>T	uc001gzi.2	-	5	602	c.431G>A	c.(430-432)CGG>CAG	p.R144Q	FMOD_uc010pqi.1_Intron|CHI3L1_uc001gzk.1_5'Flank|CHI3L1_uc001gzj.2_Missense_Mutation_p.R144Q	NM_001276	NP_001267	P36222	CH3L1_HUMAN	chitinase 3-like 1 precursor	144					chitin catabolic process	extracellular space|proteinaceous extracellular matrix	cation binding|chitinase activity|extracellular matrix structural constituent|sugar binding			pancreas(1)	1																		---	---	---	---
ZC3H11A	9877	broad.mit.edu	37	1	203819736	203819736	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:203819736C>T	uc001hac.2	+	18	2649	c.2033C>T	c.(2032-2034)GCT>GTT	p.A678V	ZC3H11A_uc001had.2_Missense_Mutation_p.A678V|ZC3H11A_uc001hae.2_Missense_Mutation_p.A678V|ZC3H11A_uc001haf.2_Missense_Mutation_p.A678V|ZC3H11A_uc010pqm.1_Missense_Mutation_p.A624V	NM_014827	NP_055642	O75152	ZC11A_HUMAN	zinc finger CCCH-type containing 11A	678							nucleic acid binding|protein binding|zinc ion binding			lung(1)|central_nervous_system(1)	2	all_cancers(21;0.0904)|all_epithelial(62;0.234)		BRCA - Breast invasive adenocarcinoma(75;0.109)															---	---	---	---
LRRN2	10446	broad.mit.edu	37	1	204587612	204587612	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:204587612C>A	uc001hbe.1	-	3	1897	c.1509G>T	c.(1507-1509)GTG>GTT	p.V503V	MDM4_uc001hbd.1_Intron|LRRN2_uc001hbf.1_Silent_p.V503V|LRRN2_uc009xbf.1_Silent_p.V503V|MDM4_uc001hbc.2_Intron	NM_006338	NP_006329	O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2 precursor	503	Ig-like C2-type.|Extracellular (Potential).				cell adhesion	integral to membrane	receptor activity			central_nervous_system(2)	2	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)															---	---	---	---
TMCC2	9911	broad.mit.edu	37	1	205238532	205238532	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:205238532G>A	uc001hbz.1	+	4	1646	c.1202G>A	c.(1201-1203)GGC>GAC	p.G401D	TMCC2_uc010prf.1_Missense_Mutation_p.G323D|TMCC2_uc001hca.2_Missense_Mutation_p.G176D|TMCC2_uc001hcb.1_Missense_Mutation_p.G161D|TMCC2_uc001hcc.1_Missense_Mutation_p.G22D|TMCC2_uc001hcd.2_Missense_Mutation_p.G168D	NM_014858	NP_055673	O75069	TMCC2_HUMAN	transmembrane and coiled-coil domain family 2	401						integral to membrane	protein binding			pancreas(1)	1	Breast(84;0.0871)		BRCA - Breast invasive adenocarcinoma(75;0.117)															---	---	---	---
LGTN	1939	broad.mit.edu	37	1	206769145	206769145	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:206769145G>T	uc001heh.2	-	13	1640	c.1431C>A	c.(1429-1431)CCC>CCA	p.P477P	LGTN_uc009xbw.2_Silent_p.P353P	NM_006893	NP_008824	P41214	EIF2D_HUMAN	ligatin	477					intracellular protein transport	cytoplasm	protein binding|receptor activity|translation initiation factor activity				0	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)															---	---	---	---
IL20	50604	broad.mit.edu	37	1	207039973	207039973	+	Silent	SNP	C	A	A	rs150575323	byFrequency	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:207039973C>A	uc001her.2	+	3	414	c.370C>A	c.(370-372)CGG>AGG	p.R124R	IL20_uc010pry.1_Silent_p.R195R|IL20_uc009xby.2_Silent_p.R124R	NM_018724	NP_061194	Q9NYY1	IL20_HUMAN	interleukin 20 precursor	124					positive regulation of keratinocyte differentiation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of inflammatory response	extracellular space	cytokine activity|interleukin-20 receptor binding				0	Breast(84;0.201)			OV - Ovarian serous cystadenocarcinoma(81;0.00459)														---	---	---	---
CR1	1378	broad.mit.edu	37	1	207739212	207739212	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:207739212A>G	uc001hfy.2	+	16	2686	c.2546A>G	c.(2545-2547)TAT>TGT	p.Y849C	CR1_uc009xcl.1_Intron|CR1_uc001hfx.2_Missense_Mutation_p.Y1299C|CR1_uc009xck.1_Intron	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	849	Extracellular (Potential).|Sushi 13.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3																		---	---	---	---
CR1	1378	broad.mit.edu	37	1	207782932	207782932	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:207782932T>C	uc001hfy.2	+	29	4984	c.4844T>C	c.(4843-4845)ATC>ACC	p.I1615T	CR1_uc009xcl.1_Missense_Mutation_p.I1165T|CR1_uc001hfx.2_Missense_Mutation_p.I2065T	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	1615	Extracellular (Potential).|Sushi 25.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3																		---	---	---	---
LAMB3	3914	broad.mit.edu	37	1	209788709	209788709	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:209788709C>T	uc001hhg.2	-	22	3816	c.3426G>A	c.(3424-3426)CTG>CTA	p.L1142L	LAMB3_uc009xco.2_Silent_p.L1142L|LAMB3_uc001hhh.2_Silent_p.L1142L	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	1142	Domain I.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)														---	---	---	---
LAMB3	3914	broad.mit.edu	37	1	209789929	209789929	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:209789929T>C	uc001hhg.2	-	21	3659	c.3269A>G	c.(3268-3270)GAC>GGC	p.D1090G	LAMB3_uc009xco.2_Missense_Mutation_p.D1090G|LAMB3_uc001hhh.2_Missense_Mutation_p.D1090G	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	1090	Domain I.|Potential.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)														---	---	---	---
TRAF3IP3	80342	broad.mit.edu	37	1	209953828	209953828	+	Silent	SNP	C	A	A	rs148709289		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:209953828C>A	uc001hho.2	+	15	1616	c.1326C>A	c.(1324-1326)CCC>CCA	p.P442P	TRAF3IP3_uc001hhn.2_Silent_p.P422P|TRAF3IP3_uc009xcr.2_Silent_p.P442P	NM_025228	NP_079504	Q9Y228	T3JAM_HUMAN	TRAF3-interacting JNK-activating modulator	442	Cytoplasmic (Potential).					integral to membrane	protein binding			large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.045)														---	---	---	---
SERTAD4	56256	broad.mit.edu	37	1	210415037	210415037	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:210415037A>G	uc001hhy.2	+	4	605	c.426A>G	c.(424-426)GAA>GAG	p.E142E	SERTAD4_uc009xcw.2_Silent_p.E142E	NM_019605	NP_062551	Q9NUC0	SRTD4_HUMAN	SERTA domain containing 4	142	SERTA.						protein binding			ovary(1)|pancreas(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0237)|all cancers(67;0.127)														---	---	---	---
KCNH1	3756	broad.mit.edu	37	1	210857460	210857460	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:210857460G>A	uc001hib.2	-	11	2303	c.2133C>T	c.(2131-2133)AGC>AGT	p.S711S	KCNH1_uc001hic.2_Silent_p.S684S	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	711	Cytoplasmic (Potential).|Calmodulin-binding.				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)														---	---	---	---
PPP2R5A	5525	broad.mit.edu	37	1	212519208	212519208	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:212519208C>T	uc001hjb.2	+	5	1211	c.637C>T	c.(637-639)CGA>TGA	p.R213*	PPP2R5A_uc010ptd.1_Nonsense_Mutation_p.R154*	NM_006243	NP_006234	Q15172	2A5A_HUMAN	protein phosphatase 2, regulatory subunit B	213					negative regulation of establishment of protein localization in plasma membrane|negative regulation of lipid kinase activity|positive regulation of protein dephosphorylation|signal transduction	chromosome, centromeric region|cytoplasm|nucleus|protein phosphatase type 2A complex	kinase binding|protein phosphatase type 2A regulator activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0125)|all cancers(67;0.029)|Epithelial(68;0.154)|GBM - Glioblastoma multiforme(131;0.155)														---	---	---	---
TATDN3	128387	broad.mit.edu	37	1	212981104	212981104	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:212981104T>C	uc001hjo.2	+	8	608	c.514T>C	c.(514-516)TTT>CTT	p.F172L	TATDN3_uc010ptj.1_Missense_Mutation_p.F172L|TATDN3_uc010ptk.1_Missense_Mutation_p.F172L|TATDN3_uc001hjp.2_Missense_Mutation_p.F172L|TATDN3_uc010ptl.1_Missense_Mutation_p.F151L|TATDN3_uc010ptm.1_Missense_Mutation_p.F120L	NM_001042552	NP_001036017	Q17R31	TATD3_HUMAN	TatD DNase domain containing 3 isoform 1	172						nucleus	endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00699)|all cancers(67;0.0118)|GBM - Glioblastoma multiforme(131;0.0801)|Epithelial(68;0.104)														---	---	---	---
PROX1	5629	broad.mit.edu	37	1	214169903	214169903	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:214169903C>A	uc001hkh.2	+	2	297	c.25C>A	c.(25-27)CTC>ATC	p.L9I	PROX1_uc001hkg.1_Missense_Mutation_p.L9I	NM_002763	NP_002754	Q92786	PROX1_HUMAN	prospero homeobox 1	9					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(3)|lung(1)|central_nervous_system(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)														---	---	---	---
KCNK2	3776	broad.mit.edu	37	1	215179291	215179291	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:215179291T>C	uc001hko.2	+	1	407	c.27T>C	c.(25-27)GAT>GAC	p.D9D	KCNK2_uc009xdm.2_RNA|KCNK2_uc001hkp.2_RNA	NM_001017424	NP_001017424	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2 isoform	Error:Variant_position_missing_in_O95069_after_alignment							outward rectifier potassium channel activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)													---	---	---	---
KCTD3	51133	broad.mit.edu	37	1	215777493	215777493	+	Silent	SNP	C	T	T	rs138597417	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:215777493C>T	uc001hks.2	+	13	1452	c.1158C>T	c.(1156-1158)ATC>ATT	p.I386I	KCTD3_uc001hkt.2_Silent_p.I386I|KCTD3_uc010pub.1_Silent_p.I284I|KCTD3_uc009xdn.2_Silent_p.I138I	NM_016121	NP_057205	Q9Y597	KCTD3_HUMAN	potassium channel tetramerisation domain	386						voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			ovary(3)	3				all cancers(67;0.0164)|OV - Ovarian serous cystadenocarcinoma(81;0.019)|GBM - Glioblastoma multiforme(131;0.0862)|Epithelial(68;0.13)														---	---	---	---
USH2A	7399	broad.mit.edu	37	1	216496967	216496967	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:216496967A>G	uc001hku.1	-	8	1786	c.1399T>C	c.(1399-1401)TAC>CAC	p.Y467H	USH2A_uc001hkv.2_Missense_Mutation_p.Y467H	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	467	Laminin N-terminal.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)											HNSCC(13;0.011)			---	---	---	---
TGFB2	7042	broad.mit.edu	37	1	218607454	218607454	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:218607454A>G	uc001hlm.2	+	3	1194	c.541A>G	c.(541-543)ACC>GCC	p.T181A	TGFB2_uc001hln.2_Missense_Mutation_p.T209A|TGFB2_uc010pue.1_RNA|TGFB2_uc001hlo.2_RNA	NM_003238	NP_003229	P61812	TGFB2_HUMAN	transforming growth factor, beta 2 isoform 2	181					activation of protein kinase activity|angiogenesis|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cardioblast differentiation|catagen|cell cycle arrest|cell death|cell growth|cell-cell junction organization|cell-cell signaling|collagen fibril organization|dopamine biosynthetic process|embryonic digestive tract development|eye development|glial cell migration|hair follicle morphogenesis|hemopoiesis|menstrual cycle phase|negative regulation of alkaline phosphatase activity|negative regulation of cell growth|negative regulation of epithelial cell proliferation|negative regulation of immune response|negative regulation of macrophage cytokine production|neuron development|neutrophil chemotaxis|odontogenesis|pathway-restricted SMAD protein phosphorylation|platelet activation|platelet degranulation|positive regulation of cardioblast differentiation|positive regulation of catagen|positive regulation of cell adhesion mediated by integrin|positive regulation of cell cycle|positive regulation of cell division|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of epithelial cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of heart contraction|positive regulation of immune response|positive regulation of integrin biosynthetic process|positive regulation of neuron apoptosis|positive regulation of ossification|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein secretion|positive regulation of stress-activated MAPK cascade|regulation of transforming growth factor-beta2 production|response to hypoxia|response to progesterone stimulus|salivary gland morphogenesis|SMAD protein import into nucleus|somatic stem cell division|transforming growth factor beta receptor signaling pathway	axon|extracellular matrix|extracellular space|neuronal cell body|platelet alpha granule lumen	beta-amyloid binding|cytokine activity|growth factor activity|protein heterodimerization activity|protein homodimerization activity|receptor signaling protein serine/threonine kinase activity|type II transforming growth factor beta receptor binding				0				all cancers(67;0.0459)|OV - Ovarian serous cystadenocarcinoma(81;0.049)|GBM - Glioblastoma multiforme(131;0.0776)														---	---	---	---
TGFB2	7042	broad.mit.edu	37	1	218610849	218610849	+	Intron	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:218610849A>G	uc001hlm.2	+						TGFB2_uc001hln.2_Intron|TGFB2_uc010pue.1_Intron|TGFB2_uc001hlo.2_Intron	NM_003238	NP_003229			transforming growth factor, beta 2 isoform 2						activation of protein kinase activity|angiogenesis|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cardioblast differentiation|catagen|cell cycle arrest|cell death|cell growth|cell-cell junction organization|cell-cell signaling|collagen fibril organization|dopamine biosynthetic process|embryonic digestive tract development|eye development|glial cell migration|hair follicle morphogenesis|hemopoiesis|menstrual cycle phase|negative regulation of alkaline phosphatase activity|negative regulation of cell growth|negative regulation of epithelial cell proliferation|negative regulation of immune response|negative regulation of macrophage cytokine production|neuron development|neutrophil chemotaxis|odontogenesis|pathway-restricted SMAD protein phosphorylation|platelet activation|platelet degranulation|positive regulation of cardioblast differentiation|positive regulation of catagen|positive regulation of cell adhesion mediated by integrin|positive regulation of cell cycle|positive regulation of cell division|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of epithelial cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of heart contraction|positive regulation of immune response|positive regulation of integrin biosynthetic process|positive regulation of neuron apoptosis|positive regulation of ossification|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein secretion|positive regulation of stress-activated MAPK cascade|regulation of transforming growth factor-beta2 production|response to hypoxia|response to progesterone stimulus|salivary gland morphogenesis|SMAD protein import into nucleus|somatic stem cell division|transforming growth factor beta receptor signaling pathway	axon|extracellular matrix|extracellular space|neuronal cell body|platelet alpha granule lumen	beta-amyloid binding|cytokine activity|growth factor activity|protein heterodimerization activity|protein homodimerization activity|receptor signaling protein serine/threonine kinase activity|type II transforming growth factor beta receptor binding				0				all cancers(67;0.0459)|OV - Ovarian serous cystadenocarcinoma(81;0.049)|GBM - Glioblastoma multiforme(131;0.0776)														---	---	---	---
LBR	3930	broad.mit.edu	37	1	225598068	225598068	+	Silent	SNP	G	A	A	rs149483088		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:225598068G>A	uc001hoy.2	-	10	1382	c.1239C>T	c.(1237-1239)CGC>CGT	p.R413R	LBR_uc001hoz.2_Silent_p.R413R|LBR_uc001hpa.1_Silent_p.R413R	NM_002296	NP_002287	Q14739	LBR_HUMAN	lamin B receptor	413					cholesterol biosynthetic process	integral to nuclear inner membrane	chromo shadow domain binding|delta14-sterol reductase activity|DNA binding|lamin binding|receptor activity			ovary(1)|skin(1)	2	Breast(184;0.165)			GBM - Glioblastoma multiforme(131;0.117)														---	---	---	---
PARP1	142	broad.mit.edu	37	1	226562030	226562030	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:226562030G>A	uc001hqd.3	-	14	2138	c.1967C>T	c.(1966-1968)ACA>ATA	p.T656I		NM_001618	NP_001609	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase family, member 1	656					cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			lung(3)|ovary(2)|breast(2)|skin(2)|upper_aerodigestive_tract(1)	10	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)									Direct_reversal_of_damage|PARP_enzymes_that_bind_to_DNA					---	---	---	---
OBSCN	84033	broad.mit.edu	37	1	228434434	228434434	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:228434434C>T	uc009xez.1	+	13	4007	c.3963C>T	c.(3961-3963)GGC>GGT	p.G1321G	OBSCN_uc001hsn.2_Silent_p.G1321G	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	1321	Ig-like 13.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)																---	---	---	---
OBSCN	84033	broad.mit.edu	37	1	228468282	228468282	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:228468282G>A	uc009xez.1	+	30	8026	c.7982G>A	c.(7981-7983)CGC>CAC	p.R2661H	OBSCN_uc001hsn.2_Missense_Mutation_p.R2661H|OBSCN_uc001hsp.1_Missense_Mutation_p.R360H|OBSCN_uc001hsq.1_5'UTR	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	2661	Ig-like 26.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)																---	---	---	---
OBSCN	84033	broad.mit.edu	37	1	228505275	228505275	+	Missense_Mutation	SNP	C	A	A	rs113376653	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:228505275C>A	uc009xez.1	+	52	13716	c.13672C>A	c.(13672-13674)CGC>AGC	p.R4558S	OBSCN_uc001hsn.2_Missense_Mutation_p.R4558S	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	4558	Fibronectin type-III 3.		R -> H (in a colorectal cancer sample; somatic mutation).		apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)																---	---	---	---
URB2	9816	broad.mit.edu	37	1	229770731	229770731	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:229770731G>A	uc001hts.1	+	4	507	c.371G>A	c.(370-372)CGA>CAA	p.R124Q	URB2_uc009xfd.1_Missense_Mutation_p.R124Q	NM_014777	NP_055592	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog	124						nucleolus				central_nervous_system(2)|ovary(1)	3																		---	---	---	---
C1orf198	84886	broad.mit.edu	37	1	230979463	230979463	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:230979463C>T	uc001hub.2	-	3	608	c.564G>A	c.(562-564)GCG>GCA	p.A188A	C1orf198_uc009xfh.1_Silent_p.A58A|C1orf198_uc001huc.1_5'UTR|C1orf198_uc001hud.1_Silent_p.A150A	NM_032800	NP_116189	Q9H425	CA198_HUMAN	hypothetical protein LOC84886 isoform 1	188											0	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)																---	---	---	---
SIPA1L2	57568	broad.mit.edu	37	1	232581327	232581327	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:232581327C>T	uc001hvg.2	-	9	3459	c.3301G>A	c.(3301-3303)GCT>ACT	p.A1101T	SIPA1L2_uc001hvf.2_Missense_Mutation_p.A175T	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	1101					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)																---	---	---	---
KIAA1804	84451	broad.mit.edu	37	1	233507898	233507898	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:233507898C>T	uc001hvt.3	+	6	1928	c.1667C>T	c.(1666-1668)GCC>GTC	p.A556V	KIAA1804_uc001hvs.1_Missense_Mutation_p.A556V	NM_032435	NP_115811	Q5TCX8	M3KL4_HUMAN	mixed lineage kinase 4	556					activation of JUN kinase activity|protein autophosphorylation		ATP binding|MAP kinase kinase kinase activity|protein homodimerization activity			lung(5)|central_nervous_system(2)|skin(1)	8		all_cancers(173;0.000405)|all_epithelial(177;0.0345)|Prostate(94;0.122)																---	---	---	---
ARID4B	51742	broad.mit.edu	37	1	235345722	235345722	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:235345722A>C	uc001hwq.2	-	20	3010	c.2512T>G	c.(2512-2514)TCA>GCA	p.S838A	ARID4B_uc001hwr.2_Missense_Mutation_p.S752A|ARID4B_uc001hws.3_Missense_Mutation_p.S752A|ARID4B_uc001hwp.2_RNA|ARID4B_uc001hwt.3_Missense_Mutation_p.S519A	NM_016374	NP_057458	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B isoform 1	838					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			ovary(2)|lung(1)	3	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)															---	---	---	---
LYST	1130	broad.mit.edu	37	1	235840481	235840481	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:235840481A>C	uc001hxj.2	-	50	11123	c.10948T>G	c.(10948-10950)TAT>GAT	p.Y3650D	LYST_uc001hxi.2_Missense_Mutation_p.Y874D	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	3650	WD 4.				defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)											Chediak-Higashi_syndrome				---	---	---	---
LYST	1130	broad.mit.edu	37	1	235972552	235972552	+	Silent	SNP	C	A	A	rs140648262	byFrequency	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:235972552C>A	uc001hxj.2	-	5	1741	c.1566G>T	c.(1564-1566)TCG>TCT	p.S522S	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA|LYST_uc001hxl.1_Silent_p.S522S	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	522					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)											Chediak-Higashi_syndrome				---	---	---	---
NID1	4811	broad.mit.edu	37	1	236208817	236208817	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:236208817T>C	uc001hxo.2	-	3	794	c.692A>G	c.(691-693)AAG>AGG	p.K231R	NID1_uc009xgd.2_Missense_Mutation_p.K231R	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	231	NIDO.				cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)													---	---	---	---
RYR2	6262	broad.mit.edu	37	1	237919637	237919637	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:237919637A>G	uc001hyl.1	+	81	11315	c.11195A>G	c.(11194-11196)CAC>CGC	p.H3732R	RYR2_uc010pya.1_Missense_Mutation_p.H147R	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3732					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)															---	---	---	---
RGS7	6000	broad.mit.edu	37	1	240990446	240990446	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:240990446C>A	uc001hyv.2	-	10	966	c.636G>T	c.(634-636)GTG>GTT	p.V212V	RGS7_uc010pyh.1_Silent_p.V186V|RGS7_uc010pyj.1_Silent_p.V128V|RGS7_uc001hyu.2_Silent_p.V212V|RGS7_uc009xgn.1_Silent_p.V159V|RGS7_uc001hyw.2_Silent_p.V212V|RGS7_uc001hyt.2_Silent_p.V44V	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	212					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)															---	---	---	---
CHML	1122	broad.mit.edu	37	1	241798364	241798364	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:241798364T>C	uc001hzd.2	-	1	869	c.705A>G	c.(703-705)TCA>TCG	p.S235S	OPN3_uc001hza.2_Intron|OPN3_uc001hzb.2_Intron|OPN3_uc001hzc.2_Intron	NM_001821	NP_001812	P26374	RAE2_HUMAN	choroideremia-like Rab escort protein 2	235					intracellular protein transport|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			ovary(4)|skin(2)	6	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)															---	---	---	---
EXO1	9156	broad.mit.edu	37	1	242030359	242030359	+	Splice_Site	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:242030359T>C	uc001hzh.2	+	11	1807	c.1267_splice	c.e11+2	p.A423_splice	EXO1_uc001hzi.2_Splice_Site_p.A423_splice|EXO1_uc001hzj.2_Splice_Site_p.A423_splice|EXO1_uc009xgq.2_Splice_Site_p.E423_splice	NM_130398	NP_569082			exonuclease 1 isoform b						meiosis|mismatch repair	nucleus	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|flap endonuclease activity|metal ion binding|protein binding|protein binding|ribonuclease H activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity			ovary(2)|lung(2)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;0.0555)	OV - Ovarian serous cystadenocarcinoma(106;0.0107)										Direct_reversal_of_damage|Editing_and_processing_nucleases					---	---	---	---
ADSS	159	broad.mit.edu	37	1	244580919	244580919	+	Intron	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:244580919A>G	uc001iaj.2	-							NM_001126	NP_001117			adenylosuccinate synthase						AMP biosynthetic process|immune system process|purine base metabolic process	cytosol|plasma membrane	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			ovary(2)|kidney(1)	3	all_cancers(71;2.17e-05)|all_epithelial(71;0.00015)|all_neural(11;0.0269)|Breast(184;0.0654)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0874)|Lung NSC(105;0.121)	all_cancers(173;0.0896)|all_epithelial(177;0.172)	all cancers(7;9.71e-08)|GBM - Glioblastoma multiforme(7;1.28e-05)|OV - Ovarian serous cystadenocarcinoma(106;0.0014)		L-Aspartic Acid(DB00128)													---	---	---	---
ZNF695	57116	broad.mit.edu	37	1	247150914	247150914	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:247150914A>G	uc009xgu.2	-	4	1048	c.903T>C	c.(901-903)TGT>TGC	p.C301C	ZNF695_uc001ica.2_Intron|ZNF695_uc001icb.1_Intron|ZNF695_uc009xgt.1_Intron|ZNF695_uc001ibx.2_Intron|ZNF695_uc001iby.2_Intron	NM_020394	NP_065127	Q8IW36	ZN695_HUMAN	zinc finger protein SBZF3	301	C2H2-type 6.				regulation of transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)															---	---	---	---
OR2G3	81469	broad.mit.edu	37	1	247769239	247769239	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:247769239A>G	uc010pyz.1	+	1	352	c.352A>G	c.(352-354)ATG>GTG	p.M118V		NM_001001914	NP_001001914	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G,	118	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)															---	---	---	---
OR2W3	343171	broad.mit.edu	37	1	248059019	248059019	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:248059019C>T	uc001idp.1	+	3	400	c.131C>T	c.(130-132)ACC>ATC	p.T44I	OR2W3_uc010pzb.1_Missense_Mutation_p.T44I	NM_001001957	NP_001001957	Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W,	44	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|pancreas(1)	3	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)															---	---	---	---
OR2M5	127059	broad.mit.edu	37	1	248309326	248309326	+	Missense_Mutation	SNP	C	A	A	rs150445512	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:248309326C>A	uc010pze.1	+	1	877	c.877C>A	c.(877-879)CGC>AGC	p.R293S		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	293	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)															---	---	---	---
OR2T27	403239	broad.mit.edu	37	1	248813394	248813394	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:248813394A>G	uc010pzo.1	-	1	792	c.792T>C	c.(790-792)TCT>TCC	p.S264S		NM_001001824	NP_001001824	Q8NH04	O2T27_HUMAN	olfactory receptor, family 2, subfamily T,	264	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;1.15e-05)|all_epithelial(71;5.29e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.089)|Lung NSC(105;0.0969)|Melanoma(84;0.199)	all_cancers(173;0.237)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)															---	---	---	---
SH3BP5L	80851	broad.mit.edu	37	1	249107289	249107289	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:249107289C>T	uc001iew.1	-	6	1162	c.610G>A	c.(610-612)GCT>ACT	p.A204T	SH3BP5L_uc010pzp.1_Missense_Mutation_p.A97T|SH3BP5L_uc010pzq.1_Missense_Mutation_p.A172T|SH3BP5L_uc001iev.1_Missense_Mutation_p.A85T	NM_030645	NP_085148	Q7L8J4	3BP5L_HUMAN	SH3-binding domain protein 5-like	204	Potential.										0	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)															---	---	---	---
TMEM18	129787	broad.mit.edu	37	2	675542	675542	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:675542T>C	uc002qwl.2	-	2	240	c.146A>G	c.(145-147)TAC>TGC	p.Y49C	TMEM18_uc002qwk.2_RNA|uc002qwm.1_5'Flank	NM_152834	NP_690047	Q96B42	TMM18_HUMAN	transmembrane protein 18	49					cell migration	integral to membrane|nuclear membrane				ovary(1)	1	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;5.27e-05)|all_epithelial(98;2.11e-06)|Ovarian(717;0.0253)		all cancers(51;1.95e-21)|Epithelial(75;9.47e-21)|OV - Ovarian serous cystadenocarcinoma(76;8.15e-18)|GBM - Glioblastoma multiforme(21;0.0285)														---	---	---	---
TPO	7173	broad.mit.edu	37	2	1500522	1500522	+	Missense_Mutation	SNP	C	T	T	rs113070603		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:1500522C>T	uc002qww.2	+	13	2462	c.2371C>T	c.(2371-2373)CCT>TCT	p.P791S	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Missense_Mutation_p.P734S|TPO_uc002qwr.2_Missense_Mutation_p.P791S|TPO_uc002qwx.2_Missense_Mutation_p.P734S|TPO_uc010yio.1_Missense_Mutation_p.P618S|TPO_uc010yip.1_Missense_Mutation_p.P791S|TPO_uc002qwy.1_Missense_Mutation_p.P131S|TPO_uc002qwz.2_Intron	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	791	Extracellular (Potential).|Sushi.				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)													---	---	---	---
TPO	7173	broad.mit.edu	37	2	1544465	1544465	+	Silent	SNP	G	A	A	rs149611408		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:1544465G>A	uc002qww.2	+	16	2809	c.2718G>A	c.(2716-2718)CCG>CCA	p.P906P	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Silent_p.P849P|TPO_uc002qwr.2_Silent_p.P906P|TPO_uc002qwx.2_Silent_p.P849P|TPO_uc010yio.1_Silent_p.P733P|TPO_uc010yip.1_Silent_p.P862P|TPO_uc002qwy.1_Silent_p.P202P|TPO_uc002qwz.2_Intron	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	906	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)													---	---	---	---
PXDN	7837	broad.mit.edu	37	2	1670198	1670198	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:1670198G>A	uc002qxa.2	-	10	1143	c.1079C>T	c.(1078-1080)ACG>ATG	p.T360M	PXDN_uc002qxb.1_Missense_Mutation_p.T360M|PXDN_uc002qxc.1_Missense_Mutation_p.T177M	NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	360	Ig-like C2-type 2.				extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)														---	---	---	---
PXDN	7837	broad.mit.edu	37	2	1680796	1680796	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:1680796C>T	uc002qxa.2	-	8	815	c.751G>A	c.(751-753)GAG>AAG	p.E251K	PXDN_uc002qxb.1_Missense_Mutation_p.E251K|PXDN_uc002qxc.1_Missense_Mutation_p.E68K	NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	251	Ig-like C2-type 1.				extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)														---	---	---	---
PXDN	7837	broad.mit.edu	37	2	1684063	1684063	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:1684063G>A	uc002qxa.2	-	7	696	c.632C>T	c.(631-633)GCG>GTG	p.A211V	PXDN_uc002qxb.1_Missense_Mutation_p.A211V|PXDN_uc002qxc.1_Missense_Mutation_p.A28V	NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	211	LRRCT.				extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)														---	---	---	---
MYT1L	23040	broad.mit.edu	37	2	1926341	1926341	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:1926341C>T	uc002qxe.2	-	10	2027	c.1200G>A	c.(1198-1200)GCG>GCA	p.A400A	MYT1L_uc002qxd.2_Silent_p.A400A|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	400					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)														---	---	---	---
COLEC11	78989	broad.mit.edu	37	2	3687869	3687869	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:3687869T>C	uc002qya.2	+	5	424	c.276T>C	c.(274-276)GGT>GGC	p.G92G	COLEC11_uc002qxz.2_Silent_p.G89G|COLEC11_uc002qyb.2_Silent_p.G68G|COLEC11_uc002qyc.2_Silent_p.G68G|COLEC11_uc010ewo.2_Silent_p.G44G|COLEC11_uc010ewp.2_Silent_p.G66G|COLEC11_uc010ewq.2_Silent_p.G42G|COLEC11_uc010ewr.2_Silent_p.G42G|COLEC11_uc010ews.2_Silent_p.G18G	NM_024027	NP_076932	Q9BWP8	COL11_HUMAN	collectin sub-family member 11 isoform a	92	Collagen-like.					collagen	mannose binding				0	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.127)														---	---	---	---
HPCAL1	3241	broad.mit.edu	37	2	10566920	10566920	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:10566920C>T	uc002raj.2	+	5	929	c.555C>T	c.(553-555)TGC>TGT	p.C185C	HPCAL1_uc002rak.2_Silent_p.C185C|HPCAL1_uc002ral.2_Silent_p.C185C|HPCAL1_uc010exe.2_RNA|HPCAL1_uc010exf.2_Silent_p.C185C	NM_002149	NP_002140	P37235	HPCL1_HUMAN	hippocalcin-like 1	185							calcium ion binding			pancreas(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.214)														---	---	---	---
NTSR2	23620	broad.mit.edu	37	2	11809758	11809758	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:11809758G>A	uc002rbq.3	-	1	572	c.498C>T	c.(496-498)CTC>CTT	p.L166L		NM_012344	NP_036476	O95665	NTR2_HUMAN	neurotensin receptor 2	166	Helical; Name=4; (Potential).				sensory perception	integral to plasma membrane					0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.129)|OV - Ovarian serous cystadenocarcinoma(76;0.24)	Levocabastine(DB01106)													---	---	---	---
MSGN1	343930	broad.mit.edu	37	2	17998228	17998228	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:17998228G>A	uc010yjt.1	+	1	443	c.443G>A	c.(442-444)CGG>CAG	p.R148Q		NM_001105569	NP_001099039	A6NI15	MSGN1_HUMAN	mesogenin 1	148	Helix-loop-helix motif.				cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)																	---	---	---	---
OSR1	130497	broad.mit.edu	37	2	19553164	19553164	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:19553164C>A	uc002rdc.2	-	2	706	c.403G>T	c.(403-405)GGT>TGT	p.G135C		NM_145260	NP_660303	Q8TAX0	OSR1_HUMAN	odd-skipped related 1	135					chondrocyte differentiation|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic leg joint morphogenesis|embryonic skeletal joint morphogenesis|heart development|mesangial cell development|mesonephric duct morphogenesis|metanephric cap mesenchymal cell proliferation involved in metanephros development|metanephric glomerulus vasculature development|metanephric interstitial cell development|metanephric mesenchymal cell differentiation|metanephric nephron tubule development|metanephric smooth muscle tissue development|middle ear morphogenesis|negative regulation of apoptosis|negative regulation of nephron tubule epithelial cell differentiation|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|pattern specification involved in metanephros development|positive regulation of bone mineralization|positive regulation of epithelial cell proliferation|positive regulation of gastrulation|positive regulation of transcription from RNA polymerase II promoter|pronephros development|renal vesicle progenitor cell differentiation|specification of anterior mesonephric tubule identity|specification of posterior mesonephric tubule identity|stem cell differentiation|transcription, DNA-dependent|ureter urothelium development|ureteric bud development	nucleolus	nucleic acid binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)	Acute lymphoblastic leukemia(84;0.221)																---	---	---	---
WDR35	57539	broad.mit.edu	37	2	20130156	20130156	+	Splice_Site	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:20130156C>T	uc002rdi.2	-	26	3262	c.3154_splice	c.e26+1	p.A1052_splice	WDR35_uc002rdj.2_Splice_Site_p.A1041_splice|WDR35_uc010ext.2_Splice_Site|WDR35_uc002rdh.2_Splice_Site_p.V525_splice	NM_001006657	NP_001006658			WD repeat domain 35 isoform 1											ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
GDF7	151449	broad.mit.edu	37	2	20870891	20870891	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:20870891G>A	uc002rdz.1	+	2	1635	c.1059G>A	c.(1057-1059)CCG>CCA	p.P353P		NM_182828	NP_878248	Q7Z4P5	GDF7_HUMAN	growth differentiation factor 7 preproprotein	353					activin receptor signaling pathway|BMP signaling pathway|growth|pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
ADCY3	109	broad.mit.edu	37	2	25057655	25057655	+	Intron	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:25057655G>T	uc002rfs.3	-						ADCY3_uc002rfr.3_Intron|ADCY3_uc010ykm.1_Intron	NM_004036	NP_004027			adenylate cyclase 3						activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			breast(3)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)																	---	---	---	---
POMC	5443	broad.mit.edu	37	2	25384348	25384348	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:25384348T>C	uc002rfy.1	-	4	669	c.406A>G	c.(406-408)AAG>GAG	p.K136E	POMC_uc002rfz.1_Missense_Mutation_p.K136E|POMC_uc002rga.1_Missense_Mutation_p.K136E	NM_001035256	NP_001030333	P01189	COLI_HUMAN	proopiomelanocortin preproprotein	136					cell-cell signaling|cellular nitrogen compound metabolic process|cellular pigmentation|generation of precursor metabolites and energy|hormone biosynthetic process|negative regulation of tumor necrosis factor production|neuropeptide signaling pathway|peptide hormone processing|positive regulation of transcription from RNA polymerase II promoter|regulation of appetite|regulation of blood pressure	extracellular space|stored secretory granule	hormone activity|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Hydrocortisone(DB00741)|Loperamide(DB00836)|Trilostane(DB01108)													---	---	---	---
DNMT3A	1788	broad.mit.edu	37	2	25471002	25471002	+	Silent	SNP	G	T	T	rs77558739	byFrequency;by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:25471002G>T	uc002rgc.2	-	7	1016	c.759C>A	c.(757-759)CCC>CCA	p.P253P	DNMT3A_uc002rgd.2_Silent_p.P253P|DNMT3A_uc010eyi.2_RNA|DNMT3A_uc002rgb.2_Silent_p.P64P	NM_022552	NP_072046	Q9Y6K1	DNM3A_HUMAN	DNA cytosine methyltransferase 3 alpha isoform	253	Interaction with DNMT1 and DNMT3B.				regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(133)|lung(4)|ovary(3)	140	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)							Mis|F|N|S		AML								---	---	---	---
DNMT3A	1788	broad.mit.edu	37	2	25523110	25523110	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:25523110G>A	uc002rgc.2	-	3	332	c.75C>T	c.(73-75)GAC>GAT	p.D25D	DNMT3A_uc002rgd.2_Silent_p.D25D|DNMT3A_uc010eyi.2_RNA|DNMT3A_uc002rge.2_Silent_p.D22D|DNMT3A_uc002rgf.2_Silent_p.D25D	NM_022552	NP_072046	Q9Y6K1	DNM3A_HUMAN	DNA cytosine methyltransferase 3 alpha isoform	25					regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(133)|lung(4)|ovary(3)	140	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)							Mis|F|N|S		AML								---	---	---	---
OTOF	9381	broad.mit.edu	37	2	26684657	26684657	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:26684657T>C	uc002rhk.2	-	43	5567	c.5440A>G	c.(5440-5442)ATG>GTG	p.M1814V	OTOF_uc010yla.1_Missense_Mutation_p.M544V|OTOF_uc002rhh.2_Missense_Mutation_p.M1047V|OTOF_uc002rhi.2_Missense_Mutation_p.M1124V|OTOF_uc002rhj.2_Missense_Mutation_p.M1047V	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	1814	Cytoplasmic (Potential).				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
EMILIN1	11117	broad.mit.edu	37	2	27306603	27306603	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27306603A>C	uc002rii.3	+	4	2592	c.2164A>C	c.(2164-2166)AGC>CGC	p.S722R	EMILIN1_uc002rik.3_5'UTR	NM_007046	NP_008977	Q9Y6C2	EMIL1_HUMAN	elastin microfibril interfacer 1 precursor	722	Potential.				cell adhesion	collagen				pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
EIF2B4	8890	broad.mit.edu	37	2	27591882	27591882	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27591882T>G	uc002rkb.2	-	4	552	c.409A>C	c.(409-411)ACC>CCC	p.T137P	EIF2B4_uc002rjz.2_Missense_Mutation_p.T157P|EIF2B4_uc002rka.2_Missense_Mutation_p.T122P|EIF2B4_uc002rkc.2_Missense_Mutation_p.T136P|EIF2B4_uc002rkd.2_5'UTR|EIF2B4_uc002rke.2_Missense_Mutation_p.T106P|EIF2B4_uc002rkf.1_Missense_Mutation_p.T106P|SNX17_uc010ylj.1_5'Flank|SNX17_uc002rkg.1_5'Flank|SNX17_uc010ylk.1_5'Flank|SNX17_uc010eza.1_5'Flank|SNX17_uc002rki.1_5'Flank|SNX17_uc002rkh.1_5'Flank|SNX17_uc010yll.1_5'Flank|SNX17_uc010ylm.1_5'Flank|SNX17_uc010yln.1_5'Flank|SNX17_uc010ylo.1_5'Flank|SNX17_uc010ylp.1_5'Flank|SNX17_uc010ylq.1_5'Flank	NM_001034116	NP_001029288	Q9UI10	EI2BD_HUMAN	eukaryotic translation initiation factor 2B,	137					myelination|negative regulation of translational initiation in response to stress|oligodendrocyte development|ovarian follicle development|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex	translation initiation factor activity|translation initiation factor binding				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
C2orf16	84226	broad.mit.edu	37	2	27801187	27801187	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27801187C>T	uc002rkz.3	+	1	1799	c.1748C>T	c.(1747-1749)ACA>ATA	p.T583I		NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	583										large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
C2orf16	84226	broad.mit.edu	37	2	27803773	27803773	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27803773A>G	uc002rkz.3	+	1	4385	c.4334A>G	c.(4333-4335)TAC>TGC	p.Y1445C	ZNF512_uc010ylv.1_5'Flank|ZNF512_uc010ylw.1_5'Flank|ZNF512_uc002rlb.2_5'Flank|ZNF512_uc010ylx.1_5'Flank|ZNF512_uc002rlc.2_5'Flank|ZNF512_uc002rla.2_5'Flank|ZNF512_uc010yly.1_5'Flank|ZNF512_uc010ylz.1_5'Flank	NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	1445										large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
RBKS	64080	broad.mit.edu	37	2	28050499	28050499	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:28050499G>A	uc002rlo.1	-	7	741	c.730C>T	c.(730-732)CTG>TTG	p.L244L	RBKS_uc010ezi.1_Silent_p.L177L|RBKS_uc010ymg.1_Silent_p.L244L	NM_022128	NP_071411	Q9H477	RBSK_HUMAN	ribokinase	244					D-ribose metabolic process		ATP binding|ribokinase activity			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
EHD3	30845	broad.mit.edu	37	2	31467323	31467323	+	Intron	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:31467323G>A	uc002rnu.2	+						EHD3_uc010ymt.1_Intron	NM_014600	NP_055415			EH-domain containing 3						blood coagulation|endocytic recycling|protein homooligomerization	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			skin(2)	2	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
TTC27	55622	broad.mit.edu	37	2	32961876	32961876	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:32961876A>G	uc002rom.2	+	12	1676	c.1445A>G	c.(1444-1446)CAC>CGC	p.H482R	TTC27_uc010ymx.1_Missense_Mutation_p.H432R|TTC27_uc002ron.2_RNA	NM_017735	NP_060205	Q6P3X3	TTC27_HUMAN	tetratricopeptide repeat domain 27	482	TPR 2.						protein binding			central_nervous_system(1)	1																		---	---	---	---
HEATR5B	54497	broad.mit.edu	37	2	37217780	37217780	+	Intron	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:37217780G>A	uc002rpp.1	-						HEATR5B_uc002rpo.1_Intron|HEATR5B_uc010ezy.1_Intron	NM_019024	NP_061897			HEAT repeat containing 5B								binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)																---	---	---	---
DHX57	90957	broad.mit.edu	37	2	39050138	39050138	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:39050138C>T	uc002rrf.2	-	17	3387	c.3288G>A	c.(3286-3288)CCG>CCA	p.P1096P	DHX57_uc002rrd.3_Silent_p.P480P|DHX57_uc002rre.2_Silent_p.P529P	NM_198963	NP_945314	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	1096							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		all_hematologic(82;0.248)																---	---	---	---
DHX57	90957	broad.mit.edu	37	2	39095333	39095333	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:39095333C>T	uc002rrf.2	-	2	314	c.215G>A	c.(214-216)CGC>CAC	p.R72H	DHX57_uc002rre.2_5'Flank|DHX57_uc002rrg.2_Missense_Mutation_p.R72H	NM_198963	NP_945314	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	72							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		all_hematologic(82;0.248)																---	---	---	---
PKDCC	91461	broad.mit.edu	37	2	42281307	42281307	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:42281307C>T	uc002rsg.2	+	3	1073	c.894C>T	c.(892-894)GAC>GAT	p.D298D		NM_138370	NP_612379	Q504Y2	PKDCC_HUMAN	protein kinase-like protein SgK493	298	Protein kinase.				cell differentiation|embryonic digestive tract development|lung alveolus development|negative regulation of Golgi to plasma membrane protein transport|ossification|palate development|positive regulation of bone mineralization|positive regulation of chondrocyte differentiation|protein transport	Golgi apparatus	ATP binding|protein kinase activity			breast(1)	1																		---	---	---	---
COX7A2L	9167	broad.mit.edu	37	2	42578377	42578377	+	Silent	SNP	C	T	T	rs79591809	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:42578377C>T	uc002rsk.2	-	3	382	c.327G>A	c.(325-327)TCG>TCA	p.S109S	COX7A2L_uc002rsl.2_RNA	NM_004718	NP_004709	O14548	COX7R_HUMAN	cytochrome c oxidase subunit VIIa polypeptide 2	109					respiratory electron transport chain	mitochondrial respiratory chain	cytochrome-c oxidase activity|electron carrier activity				0																		---	---	---	---
MCFD2	90411	broad.mit.edu	37	2	47135054	47135054	+	Silent	SNP	C	T	T	rs144700781		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:47135054C>T	uc002rvk.2	-	3	298	c.204G>A	c.(202-204)TCG>TCA	p.S68S	MCFD2_uc002rvl.2_Silent_p.S16S|MCFD2_uc010fba.2_Silent_p.S66S|MCFD2_uc010yof.1_Silent_p.S49S	NM_139279	NP_644808	Q8NI22	MCFD2_HUMAN	multiple coagulation factor deficiency 2	68	EF-hand 1.				post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|vesicle-mediated transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment|Golgi apparatus	calcium ion binding			central_nervous_system(1)	1		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)		Antihemophilic Factor(DB00025)													---	---	---	---
PSME4	23198	broad.mit.edu	37	2	54164655	54164655	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:54164655C>T	uc002rxp.2	-	5	624	c.568G>A	c.(568-570)GCT>ACT	p.A190T	PSME4_uc010yop.1_Missense_Mutation_p.A76T|PSME4_uc010yoq.1_RNA|PSME4_uc010fbu.1_5'UTR|PSME4_uc010fbv.1_Intron	NM_014614	NP_055429	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator	190					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			ovary(2)|breast(2)|pancreas(1)	5			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)															---	---	---	---
ARHGAP25	9938	broad.mit.edu	37	2	69049486	69049486	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:69049486T>C	uc002seu.2	+	10	1576	c.1212T>C	c.(1210-1212)GAT>GAC	p.D404D	ARHGAP25_uc010fdg.2_Silent_p.D405D|ARHGAP25_uc010yql.1_Silent_p.D365D|ARHGAP25_uc002sew.2_Silent_p.D397D|ARHGAP25_uc002sex.2_Silent_p.D398D|ARHGAP25_uc002sey.2_Silent_p.D131D	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Rho GTPase activating protein 25 isoform a	404					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|breast(2)	4																		---	---	---	---
AAK1	22848	broad.mit.edu	37	2	69741805	69741805	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:69741805T>G	uc002sfp.2	-	13	2079	c.1574A>C	c.(1573-1575)CAG>CCG	p.Q525P	AAK1_uc010fdk.2_Missense_Mutation_p.Q525P|AAK1_uc010yqm.1_Missense_Mutation_p.Q525P	NM_014911	NP_055726	Q2M2I8	AAK1_HUMAN	AP2 associated kinase 1	525	Gln-rich.					coated pit|mitochondrion|plasma membrane	ATP binding|protein serine/threonine kinase activity				0																		---	---	---	---
ZNF638	27332	broad.mit.edu	37	2	71577170	71577170	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:71577170A>G	uc002shx.2	+	2	1405	c.1086A>G	c.(1084-1086)GTA>GTG	p.V362V	ZNF638_uc010fec.2_Silent_p.V468V|ZNF638_uc010yqw.1_Intron|ZNF638_uc002shw.2_Silent_p.V362V|ZNF638_uc002shy.2_Silent_p.V362V|ZNF638_uc002shz.2_Silent_p.V362V|ZNF638_uc002sia.2_Silent_p.V362V|ZNF638_uc002sib.1_Silent_p.V362V	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	362					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4																		---	---	---	---
CCDC142	84865	broad.mit.edu	37	2	74702431	74702431	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:74702431C>T	uc002slr.2	-	7	2110	c.1717G>A	c.(1717-1719)GCC>ACC	p.A573T	MRPL53_uc002sln.2_5'Flank|CCDC142_uc002slo.2_RNA|CCDC142_uc002slq.2_Missense_Mutation_p.A566T|CCDC142_uc002slp.2_Missense_Mutation_p.A573T	NM_032779	NP_116168	Q17RM4	CC142_HUMAN	coiled-coil domain containing 142	573										central_nervous_system(1)	1																		---	---	---	---
DQX1	165545	broad.mit.edu	37	2	74746779	74746779	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:74746779C>T	uc010yrw.1	-	10	1875	c.1710G>A	c.(1708-1710)ATG>ATA	p.M570I	DQX1_uc002smc.2_Missense_Mutation_p.M131I	NM_133637	NP_598376	Q8TE96	DQX1_HUMAN	DEAQ box polypeptide 1 (RNA-dependent ATPase)	570						nucleus	ATP binding|helicase activity|nucleic acid binding			ovary(2)	2																		---	---	---	---
TACR1	6869	broad.mit.edu	37	2	75347784	75347784	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:75347784T>C	uc002sng.2	-	2	1085	c.500A>G	c.(499-501)TAC>TGC	p.Y167C	TACR1_uc002snh.2_Missense_Mutation_p.Y167C	NM_001058	NP_001049	P25103	NK1R_HUMAN	tachykinin receptor 1 isoform long	167	Helical; Name=4; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|detection of abiotic stimulus|mechanosensory behavior	integral to plasma membrane	protein binding			ovary(1)	1					Aprepitant(DB00673)|Ketamine(DB01221)|Vapreotide(DB04894)													---	---	---	---
CTNNA2	1496	broad.mit.edu	37	2	80773145	80773145	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:80773145C>T	uc010ysh.1	+	10	1502	c.1497C>T	c.(1495-1497)GCC>GCT	p.A499A	CTNNA2_uc010yse.1_Silent_p.A499A|CTNNA2_uc010ysf.1_Silent_p.A499A|CTNNA2_uc010ysg.1_Silent_p.A499A|CTNNA2_uc010ysi.1_Silent_p.A131A	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	499					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9																		---	---	---	---
SUCLG1	8802	broad.mit.edu	37	2	84668521	84668521	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:84668521A>G	uc002son.2	-	4	574	c.381T>C	c.(379-381)GCT>GCC	p.A127A	SUCLG1_uc010ysk.1_Silent_p.A114A	NM_003849	NP_003840	P53597	SUCA_HUMAN	succinate-CoA ligase, GDP-forming alpha subunit	127					tricarboxylic acid cycle		ATP citrate synthase activity|GTP binding|succinate-CoA ligase (GDP-forming) activity				0					Succinic acid(DB00139)													---	---	---	---
TCF7L1	83439	broad.mit.edu	37	2	85536512	85536512	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:85536512C>T	uc002soy.2	+	12	1768	c.1694C>T	c.(1693-1695)ACG>ATG	p.T565M		NM_031283	NP_112573	Q9HCS4	TF7L1_HUMAN	HMG-box transcription factor TCF-3	565					chromatin organization|regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)|breast(1)|central_nervous_system(1)	3																		---	---	---	---
GGCX	2677	broad.mit.edu	37	2	85779652	85779652	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:85779652G>A	uc002sps.2	-	10	1432	c.1326C>T	c.(1324-1326)GAC>GAT	p.D442D	GGCX_uc010yss.1_Silent_p.D281D|GGCX_uc010yst.1_Silent_p.D385D	NM_000821	NP_000812	P38435	VKGC_HUMAN	gamma-glutamyl carboxylase isoform 1	442	Lumenal (Potential).				blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification	endoplasmic reticulum membrane|integral to membrane|membrane fraction	gamma-glutamyl carboxylase activity			ovary(1)	1					Anisindione(DB01125)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Drotrecogin alfa(DB00055)|L-Glutamic Acid(DB00142)|Menadione(DB00170)|Phytonadione(DB01022)											OREG0014747	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
POLR1A	25885	broad.mit.edu	37	2	86266558	86266558	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:86266558G>A	uc002sqs.2	-	26	4147	c.3768C>T	c.(3766-3768)AGC>AGT	p.S1256S	POLR1A_uc010ytb.1_Silent_p.S622S|POLR1A_uc002sqt.1_Silent_p.S279S	NM_015425	NP_056240	O95602	RPA1_HUMAN	DNA-directed RNA polymerase I A	1256					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3																		---	---	---	---
Unknown	0	broad.mit.edu	37	2	89340006	89340006	+	RNA	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:89340006G>A	uc010ytr.1	-	64		c.5853C>T			uc002stl.2_Intron					Parts of antibodies, mostly variable regions.																														---	---	---	---
TEKT4	150483	broad.mit.edu	37	2	95537771	95537771	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:95537771C>T	uc002stw.1	+	1	540	c.447C>T	c.(445-447)CGC>CGT	p.R149R	uc002stv.1_Intron|TEKT4_uc010fhr.1_RNA	NM_144705	NP_653306	Q8WW24	TEKT4_HUMAN	tektin 4	149	Potential.				cell projection organization|microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(1)|breast(1)|skin(1)	3																		---	---	---	---
SNRNP200	23020	broad.mit.edu	37	2	96956125	96956125	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:96956125A>G	uc002svu.2	-	20	2767	c.2681T>C	c.(2680-2682)GTT>GCT	p.V894A	SNRNP200_uc002svw.1_5'Flank	NM_014014	NP_054733	O75643	U520_HUMAN	activating signal cointegrator 1 complex subunit	894	Helicase C-terminal 1.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(5)|skin(4)|large_intestine(1)	10																		---	---	---	---
KIAA1310	55683	broad.mit.edu	37	2	97267523	97267523	+	Intron	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:97267523A>G	uc002swn.3	-						KIAA1310_uc002swh.3_Intron|KIAA1310_uc002swi.3_Intron|KIAA1310_uc002swj.3_Intron|KIAA1310_uc002swk.3_Intron|KIAA1310_uc010fhz.2_Intron|KIAA1310_uc002swl.3_Intron|KIAA1310_uc002swm.3_Intron|KIAA1310_uc010yur.1_Intron|KIAA1310_uc002swo.2_Intron	NM_001115016	NP_001108488			hypothetical protein LOC55683 isoform a												0																		---	---	---	---
FER1L5	90342	broad.mit.edu	37	2	97368419	97368419	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:97368419C>T	uc010fia.2	+	47	5446	c.5446C>T	c.(5446-5448)CGG>TGG	p.R1816W	FER1L5_uc002sws.3_Missense_Mutation_p.R525W|FER1L5_uc002swt.3_Missense_Mutation_p.R525W|FER1L5_uc010yus.1_Missense_Mutation_p.R524W	NM_001113382	NP_001106853	A0AVI2	FR1L5_HUMAN	fer-1-like 5 isoform 2	1816	C2 6.					integral to membrane				ovary(1)	1																		---	---	---	---
ZAP70	7535	broad.mit.edu	37	2	98354255	98354255	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:98354255C>T	uc002syd.1	+	12	1725	c.1518C>T	c.(1516-1518)TAC>TAT	p.Y506Y	ZAP70_uc002sye.1_Silent_p.Y396Y|ZAP70_uc002syf.1_Silent_p.Y199Y	NM_001079	NP_001070	P43403	ZAP70_HUMAN	zeta-chain associated protein kinase 70kDa	506	Protein kinase.				immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(4)|upper_aerodigestive_tract(1)|ovary(1)	6																		---	---	---	---
TSGA10	80705	broad.mit.edu	37	2	99695187	99695187	+	Missense_Mutation	SNP	G	T	T	rs17852533		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:99695187G>T	uc002szg.3	-	10	1445	c.817C>A	c.(817-819)CTG>ATG	p.L273M	TSGA10_uc002szh.3_Missense_Mutation_p.L273M|TSGA10_uc002szi.3_Missense_Mutation_p.L273M|TSGA10_uc010fin.1_Missense_Mutation_p.L273M|TSGA10_uc010yvn.1_Missense_Mutation_p.L273M	NM_182911	NP_878915	Q9BZW7	TSG10_HUMAN	testis specific, 10	273				L -> M (in Ref. 5; AAH28366).	spermatogenesis	cytoplasm|nuclear membrane				ovary(1)|central_nervous_system(1)	2																		---	---	---	---
C2orf15	150590	broad.mit.edu	37	2	99767017	99767017	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:99767017T>C	uc002szk.2	+	4	497	c.98T>C	c.(97-99)ATC>ACC	p.I33T	TSGA10_uc002szi.3_Intron|MRPL30_uc002szl.1_Intron	NM_144706	NP_653307	Q8WU43	CB015_HUMAN	hypothetical protein LOC150590	33											0																		---	---	---	---
EIF5B	9669	broad.mit.edu	37	2	99978135	99978135	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:99978135A>G	uc002tab.2	+	4	955	c.771A>G	c.(769-771)GAA>GAG	p.E257E		NM_015904	NP_056988	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	257					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			ovary(2)|pancreas(1)	3																		---	---	---	---
NPAS2	4862	broad.mit.edu	37	2	101565870	101565870	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:101565870A>G	uc002tap.1	+	7	812	c.526A>G	c.(526-528)AGC>GGC	p.S176G	NPAS2_uc010yvt.1_Missense_Mutation_p.S241G	NM_002518	NP_002509	Q99743	NPAS2_HUMAN	neuronal PAS domain protein 2	176					central nervous system development|positive regulation of transcription from RNA polymerase II promoter|rhythmic process	transcription factor complex	DNA binding|Hsp90 protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(3)|upper_aerodigestive_tract(1)	4																		---	---	---	---
MAP4K4	9448	broad.mit.edu	37	2	102476242	102476242	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:102476242A>G	uc002tbg.2	+	15	1675	c.1620A>G	c.(1618-1620)CCA>CCG	p.P540P	MAP4K4_uc002tbc.2_Silent_p.P540P|MAP4K4_uc002tbd.2_Silent_p.P509P|MAP4K4_uc002tbe.2_Silent_p.P509P|MAP4K4_uc002tbf.2_Silent_p.P509P|MAP4K4_uc010yvy.1_Silent_p.P509P|MAP4K4_uc002tbh.2_Silent_p.P509P|MAP4K4_uc002tbi.2_Silent_p.P393P|MAP4K4_uc010yvz.1_Silent_p.P489P|MAP4K4_uc002tbk.2_Silent_p.P49P|MAP4K4_uc002tbj.1_Silent_p.P405P	NM_145687	NP_663720	O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase	540					intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			stomach(1)|lung(1)|central_nervous_system(1)|skin(1)	4																		---	---	---	---
UXS1	80146	broad.mit.edu	37	2	106717534	106717534	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:106717534C>T	uc002tdm.2	-	12	1047	c.949G>A	c.(949-951)GTC>ATC	p.V317I	UXS1_uc002tdl.2_Missense_Mutation_p.V149I|UXS1_uc002tdn.2_Missense_Mutation_p.V322I|UXS1_uc002tdo.2_Missense_Mutation_p.V260I|UXS1_uc010ywh.1_Missense_Mutation_p.V161I	NM_025076	NP_079352	Q8NBZ7	UXS1_HUMAN	UDP-glucuronate decarboxylase 1	317	Lumenal (Potential).				cellular metabolic process	Golgi cisterna membrane|integral to membrane	coenzyme binding|UDP-glucuronate decarboxylase activity			ovary(2)	2																		---	---	---	---
SULT1C4	27233	broad.mit.edu	37	2	108994805	108994805	+	Silent	SNP	C	T	T	rs144464562		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:108994805C>T	uc002tea.1	+	1	385	c.12C>T	c.(10-12)CAC>CAT	p.H4H	SULT1C4_uc002tdz.2_Silent_p.H4H|SULT1C4_uc010ywr.1_RNA|SULT1C4_uc002teb.1_Silent_p.H4H	NM_006588	NP_006579	O75897	ST1C4_HUMAN	sulfotransferase family, cytosolic, 1C, member	4					3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol	sulfotransferase activity				0																		---	---	---	---
RANBP2	5903	broad.mit.edu	37	2	109371692	109371692	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:109371692T>C	uc002tem.3	+	17	2569	c.2443T>C	c.(2443-2445)TGC>CGC	p.C815R		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	815					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18																		---	---	---	---
ANAPC1	64682	broad.mit.edu	37	2	112601029	112601029	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:112601029A>G	uc002thi.2	-	17	2247	c.2000T>C	c.(1999-2001)ATG>ACG	p.M667T		NM_022662	NP_073153	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	667					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				skin(2)	2																		---	---	---	---
ANAPC1	64682	broad.mit.edu	37	2	112608394	112608394	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:112608394T>C	uc002thi.2	-	14	1856	c.1609A>G	c.(1609-1611)ACT>GCT	p.T537A		NM_022662	NP_073153	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	537					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				skin(2)	2																		---	---	---	---
ANAPC1	64682	broad.mit.edu	37	2	112615883	112615883	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:112615883C>A	uc002thi.2	-	11	1605	c.1358G>T	c.(1357-1359)CGC>CTC	p.R453L		NM_022662	NP_073153	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	453					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				skin(2)	2																		---	---	---	---
ANAPC1	64682	broad.mit.edu	37	2	112621311	112621311	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:112621311T>C	uc002thi.2	-	9	1240	c.993A>G	c.(991-993)TCA>TCG	p.S331S		NM_022662	NP_073153	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	331					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				skin(2)	2																		---	---	---	---
IL1F9	56300	broad.mit.edu	37	2	113742478	113742478	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:113742478G>A	uc002tio.1	+	5	431	c.362G>A	c.(361-363)CGT>CAT	p.R121H	IL1F9_uc010fkr.1_Missense_Mutation_p.R86H	NM_019618	NP_062564	Q9NZH8	IL36G_HUMAN	interleukin 1 family, member 9	121					cell-cell signaling	extracellular space	cytokine activity|interleukin-1 receptor antagonist activity				0																		---	---	---	---
SLC35F5	80255	broad.mit.edu	37	2	114512832	114512832	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:114512832A>G	uc002tku.1	-	3	607	c.183T>C	c.(181-183)AGT>AGC	p.S61S	SLC35F5_uc002tkt.2_RNA|SLC35F5_uc002tkv.2_Silent_p.S55S|SLC35F5_uc002tkw.2_Silent_p.S61S	NM_025181	NP_079457	Q8WV83	S35F5_HUMAN	solute carrier family 35, member F5	61					transport	integral to membrane					0																		---	---	---	---
DPP10	57628	broad.mit.edu	37	2	116520172	116520172	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:116520172T>C	uc002tla.1	+	12	1556	c.1099T>C	c.(1099-1101)TGG>CGG	p.W367R	DPP10_uc002tlb.1_Missense_Mutation_p.W317R|DPP10_uc002tlc.1_Missense_Mutation_p.W363R|DPP10_uc002tle.2_Missense_Mutation_p.W371R|DPP10_uc002tlf.1_Missense_Mutation_p.W360R	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	367	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10																		---	---	---	---
INHBB	3625	broad.mit.edu	37	2	121103981	121103981	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:121103981G>A	uc002tmn.2	+	1	263	c.217G>A	c.(217-219)GAC>AAC	p.D73N		NM_002193	NP_002184	P09529	INHBB_HUMAN	inhibin beta B subunit preproprotein	73					activin receptor signaling pathway|cellular response to insulin stimulus|cellular response to starvation|defense response|fat cell differentiation|growth|negative regulation of follicle-stimulating hormone secretion|negative regulation of hepatocyte growth factor biosynthetic process|negative regulation of insulin secretion|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation	extracellular region|perinuclear region of cytoplasm	cytokine activity|growth factor activity|hormone activity|host cell surface receptor binding|protein homodimerization activity			pancreas(2)|skin(1)	3		Prostate(154;0.122)																---	---	---	---
TSN	7247	broad.mit.edu	37	2	122522827	122522827	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:122522827C>A	uc002tnl.2	+	6	806	c.571C>A	c.(571-573)CTG>ATG	p.L191M	TSN_uc002tnm.2_Missense_Mutation_p.L144M|TSN_uc010yze.1_3'UTR|TSN_uc010flt.2_RNA	NM_004622	NP_004613	Q15631	TSN_HUMAN	translin	191	Leucine-zipper (Potential).				DNA recombination	cytoplasm|nucleus	sequence-specific DNA binding			breast(2)|large_intestine(1)	3		Ovarian(717;0.0563)|Prostate(154;0.116)																---	---	---	---
CNTNAP5	129684	broad.mit.edu	37	2	125192170	125192170	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:125192170A>T	uc002tno.2	+	5	1003	c.639A>T	c.(637-639)CAA>CAT	p.Q213H	CNTNAP5_uc010flu.2_Missense_Mutation_p.Q213H	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	213	Laminin G-like 1.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)														---	---	---	---
CYP27C1	339761	broad.mit.edu	37	2	127952980	127952980	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:127952980C>A	uc002tod.2	-	5	781	c.650G>T	c.(649-651)AGG>ATG	p.R217M		NM_001001665	NP_001001665	Q4G0S4	C27C1_HUMAN	cytochrome P450, family 27, subfamily C,	217						membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.071)														---	---	---	---
PROC	5624	broad.mit.edu	37	2	128186037	128186037	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:128186037G>A	uc002tok.2	+	9	974	c.901G>A	c.(901-903)GCA>ACA	p.A301T	PROC_uc002tol.2_Missense_Mutation_p.A322T|PROC_uc010yzi.1_Missense_Mutation_p.A357T|PROC_uc010yzj.1_Missense_Mutation_p.A196T|PROC_uc010yzk.1_Missense_Mutation_p.A356T|PROC_uc002tom.2_Missense_Mutation_p.A335T	NM_000312	NP_000303	P04070	PROC_HUMAN	protein C	301	Peptidase S1.		A -> V (in patients with PROC deficiency).|A -> T (in patients with PROC deficiency).		blood coagulation|leukocyte migration|negative regulation of apoptosis|negative regulation of blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|protein binding|serine-type endopeptidase activity				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0673)	Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)|Sodium Tetradecyl Sulfate(DB00464)													---	---	---	---
MYO7B	4648	broad.mit.edu	37	2	128339595	128339595	+	Intron	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:128339595T>C	uc002top.2	+							NM_001080527	NP_001073996			myosin VIIB							apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)														---	---	---	---
LIMS2	55679	broad.mit.edu	37	2	128400603	128400603	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:128400603A>G	uc002tpa.2	-	5	570	c.404T>C	c.(403-405)CTG>CCG	p.L135P	LIMS2_uc002tou.2_5'Flank|LIMS2_uc002tov.2_5'UTR|LIMS2_uc002tow.2_5'UTR|LIMS2_uc002tox.2_Missense_Mutation_p.L159P|LIMS2_uc010fmb.2_Missense_Mutation_p.L45P|LIMS2_uc002toy.2_Missense_Mutation_p.L130P|LIMS2_uc010yzm.1_Missense_Mutation_p.L157P|LIMS2_uc002toz.2_Missense_Mutation_p.L130P|LIMS2_uc002tpb.2_Missense_Mutation_p.L130P|GPR17_uc010yzn.1_5'Flank|GPR17_uc002tpc.2_5'Flank|GPR17_uc010yzo.1_5'Flank|GPR17_uc002tpd.2_5'Flank	NM_001161403	NP_001154875	Q7Z4I7	LIMS2_HUMAN	LIM and senescent cell antigen-like domains 2	135					cell junction assembly	cytosol|focal adhesion|nucleus	zinc ion binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0681)														---	---	---	---
SAP130	79595	broad.mit.edu	37	2	128712741	128712741	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:128712741G>A	uc002tpp.2	-	15	2346	c.2214C>T	c.(2212-2214)GCC>GCT	p.A738A	SAP130_uc002tpn.2_Silent_p.A498A|SAP130_uc002tpo.2_Silent_p.A518A|SAP130_uc010fmd.2_Silent_p.A773A|SAP130_uc002tpq.1_Silent_p.A746A	NM_024545	NP_078821	Q9H0E3	SP130_HUMAN	Sin3A-associated protein, 130kDa isoform b	738	Pro-rich.				histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			ovary(2)|skin(2)	4	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0771)														---	---	---	---
CCDC74B	91409	broad.mit.edu	37	2	130897150	130897150	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:130897150C>T	uc002tqm.1	-	8	1183	c.1121G>A	c.(1120-1122)CGC>CAC	p.R374H	CCDC74B_uc010yzw.1_Missense_Mutation_p.R476H|CCDC74B_uc002tqn.1_Missense_Mutation_p.R308H	NM_207310	NP_997193	Q96LY2	CC74B_HUMAN	coiled-coil domain containing 74B	374											0	Colorectal(110;0.1)																	---	---	---	---
TUBA3E	112714	broad.mit.edu	37	2	130951615	130951615	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:130951615A>G	uc002tqv.2	-	4	901	c.800T>C	c.(799-801)TTC>TCC	p.F267S		NM_207312	NP_997195	Q6PEY2	TBA3E_HUMAN	tubulin, alpha 3e	267					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			skin(1)	1	Colorectal(110;0.1)																	---	---	---	---
NCKAP5	344148	broad.mit.edu	37	2	133542601	133542601	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:133542601T>A	uc002ttp.2	-	14	2157	c.1783A>T	c.(1783-1785)AGC>TGC	p.S595C	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	595							protein binding				0																		---	---	---	---
THSD7B	80731	broad.mit.edu	37	2	138208468	138208468	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:138208468G>A	uc002tva.1	+	14	2920	c.2920G>A	c.(2920-2922)GAT>AAT	p.D974N	THSD7B_uc010zbj.1_Intron	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)														---	---	---	---
HNMT	3176	broad.mit.edu	37	2	138738852	138738852	+	Intron	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:138738852G>A	uc002tvc.2	+						HNMT_uc002tve.2_Missense_Mutation_p.R86H|HNMT_uc002tvf.2_Intron	NM_006895	NP_008826			histamine N-methyltransferase isoform 1						respiratory gaseous exchange	cytoplasm	histamine N-methyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.125)	Amodiaquine(DB00613)|Histamine Phosphate(DB00667)|Quinacrine(DB01103)													---	---	---	---
LRP1B	53353	broad.mit.edu	37	2	141458106	141458106	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:141458106G>A	uc002tvj.1	-	41	7484	c.6512C>T	c.(6511-6513)GCC>GTC	p.A2171V		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2171	Extracellular (Potential).|EGF-like 5.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)											TSP Lung(27;0.18)			---	---	---	---
ZEB2	9839	broad.mit.edu	37	2	145156685	145156685	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:145156685T>C	uc002tvu.2	-	8	2549	c.2069A>G	c.(2068-2070)GAA>GGA	p.E690G	ZEB2_uc002tvv.2_Missense_Mutation_p.E684G|ZEB2_uc010zbm.1_Missense_Mutation_p.E661G|ZEB2_uc010fnp.2_Intron|ZEB2_uc010fnq.1_Missense_Mutation_p.E719G	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	690	Homeobox; atypical.					cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)														---	---	---	---
GPD2	2820	broad.mit.edu	37	2	157425876	157425876	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:157425876T>C	uc002tzf.3	+	11	1662	c.1302T>C	c.(1300-1302)GGT>GGC	p.G434G	GPD2_uc010zch.1_Silent_p.G207G|GPD2_uc002tzd.3_Silent_p.G434G|GPD2_uc002tze.1_RNA	NM_001083112	NP_001076581	P43304	GPDM_HUMAN	glycerol-3-phosphate dehydrogenase 2,	434					cellular lipid metabolic process	glycerol-3-phosphate dehydrogenase complex|mitochondrial inner membrane	calcium ion binding|sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity			ovary(1)	1																		---	---	---	---
ACVR1	90	broad.mit.edu	37	2	158634684	158634684	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:158634684C>T	uc002tzm.3	-	6	841	c.502G>A	c.(502-504)GAA>AAA	p.E168K	ACVR1_uc002tzn.3_Missense_Mutation_p.E168K|ACVR1_uc010fog.2_Missense_Mutation_p.E168K	NM_001111067	NP_001104537	Q04771	ACVR1_HUMAN	activin A receptor, type I precursor	168	Cytoplasmic (Potential).				BMP signaling pathway|G1/S transition of mitotic cell cycle|negative regulation of activin receptor signaling pathway|negative regulation of apoptosis|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	activin receptor complex	activin binding|ATP binding|follistatin binding|metal ion binding|protein homodimerization activity|SMAD binding|transforming growth factor beta binding			ovary(2)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.104)	Adenosine triphosphate(DB00171)													---	---	---	---
TANC1	85461	broad.mit.edu	37	2	160019872	160019872	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:160019872T>C	uc002uag.2	+	8	1035	c.761T>C	c.(760-762)TTA>TCA	p.L254S	TANC1_uc010fol.1_Missense_Mutation_p.L148S|TANC1_uc010zcm.1_Missense_Mutation_p.L253S|TANC1_uc010fom.1_Intron	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	254						cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
TANC1	85461	broad.mit.edu	37	2	160031474	160031474	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:160031474A>G	uc002uag.2	+	12	1788	c.1514A>G	c.(1513-1515)TAC>TGC	p.Y505C	TANC1_uc010fol.1_Missense_Mutation_p.Y399C|TANC1_uc010zcm.1_Missense_Mutation_p.Y497C|TANC1_uc010fom.1_Missense_Mutation_p.Y311C|TANC1_uc002uai.1_5'Flank	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	505						cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
DPP4	1803	broad.mit.edu	37	2	162865133	162865133	+	Silent	SNP	C	A	A	rs41268649	byFrequency;by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:162865133C>A	uc002ubz.2	-	22	2487	c.1926G>T	c.(1924-1926)TCG>TCT	p.S642S	DPP4_uc010fpb.2_Silent_p.S318S	NM_001935	NP_001926	P27487	DPP4_HUMAN	dipeptidylpeptidase IV	642	Extracellular (Potential).				cell adhesion|endothelial cell migration|negative regulation of extracellular matrix disassembly|positive regulation of cell proliferation|proteolysis|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation|T cell costimulation	apical plasma membrane|cell surface|endocytic vesicle|extracellular region|integral to membrane|invadopodium membrane|lamellipodium membrane|membrane raft	aminopeptidase activity|dipeptidyl-peptidase activity|protease binding|protein homodimerization activity|receptor activity|receptor binding|serine-type endopeptidase activity			ovary(3)	3					Sitagliptin(DB01261)													---	---	---	---
XIRP2	129446	broad.mit.edu	37	2	168104267	168104267	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:168104267G>A	uc002udx.2	+	8	6383	c.6365G>A	c.(6364-6366)GGA>GAA	p.G2122E	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.G1947E|XIRP2_uc010fpq.2_Missense_Mutation_p.G1900E|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'UTR	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1947					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14																		---	---	---	---
XIRP2	129446	broad.mit.edu	37	2	168107832	168107832	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:168107832G>T	uc002udx.2	+	8	9948	c.9930G>T	c.(9928-9930)CAG>CAT	p.Q3310H	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.Q3135H|XIRP2_uc010fpq.2_Missense_Mutation_p.Q3088H|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	3135					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14																		---	---	---	---
ABCB11	8647	broad.mit.edu	37	2	169828384	169828384	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:169828384G>T	uc002ueo.1	-	14	1737	c.1611C>A	c.(1609-1611)GCC>GCA	p.A537A	ABCB11_uc010zda.1_5'UTR|ABCB11_uc010zdb.1_Silent_p.A13A	NM_003742	NP_003733	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	537	Cytoplasmic (Potential).|ABC transporter 1.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			ovary(2)|large_intestine(2)|breast(1)	5					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)													---	---	---	---
LRP2	4036	broad.mit.edu	37	2	170072887	170072887	+	Missense_Mutation	SNP	G	A	A	rs61995913	byFrequency;by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:170072887G>A	uc002ues.2	-	35	5915	c.5702C>T	c.(5701-5703)GCC>GTC	p.A1901V		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	1901	LDL-receptor class B 17.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)													---	---	---	---
LRP2	4036	broad.mit.edu	37	2	170134319	170134319	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:170134319G>A	uc002ues.2	-	13	1921	c.1708C>T	c.(1708-1710)CGT>TGT	p.R570C	LRP2_uc010zdf.1_Intron	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	570	LDL-receptor class B 4.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)													---	---	---	---
PPIG	9360	broad.mit.edu	37	2	170488344	170488344	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:170488344T>A	uc002uez.2	+	11	1050	c.830T>A	c.(829-831)ATC>AAC	p.I277N	PPIG_uc010fpx.2_Missense_Mutation_p.I262N|PPIG_uc010fpy.2_Missense_Mutation_p.I270N|PPIG_uc002ufa.2_Missense_Mutation_p.I277N|PPIG_uc002ufb.2_Missense_Mutation_p.I277N|PPIG_uc002ufd.2_Missense_Mutation_p.I274N	NM_004792	NP_004783	Q13427	PPIG_HUMAN	peptidylprolyl isomerase G	277					protein folding|RNA splicing	nuclear matrix|nuclear speck	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|central_nervous_system(1)	3					L-Proline(DB00172)													---	---	---	---
PHOSPHO2	493911	broad.mit.edu	37	2	170558005	170558005	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:170558005T>A	uc002ufg.2	+	4	912	c.524T>A	c.(523-525)GTT>GAT	p.V175D	KLHL23_uc002ufh.1_Intron	NM_001008489	NP_001008489	Q8TCD6	PHOP2_HUMAN	phosphatase, orphan 2	175							metal ion binding|pyridoxal phosphatase activity			skin(1)	1																		---	---	---	---
MYO3B	140469	broad.mit.edu	37	2	171071345	171071345	+	Intron	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:171071345A>G	uc002ufy.2	+						MYO3B_uc002ufv.2_Intron|MYO3B_uc010fqb.1_Intron|MYO3B_uc002ufz.2_Intron|MYO3B_uc002ufw.2_Intron|MYO3B_uc002ufx.2_Intron|MYO3B_uc002uga.2_Intron	NM_138995	NP_620482			myosin IIIB isoform 2						response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			lung(8)|ovary(6)|skin(4)|central_nervous_system(1)	19																		---	---	---	---
DLX2	1746	broad.mit.edu	37	2	172966181	172966181	+	Intron	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:172966181G>A	uc002uhn.2	-						DLX2_uc010zdx.1_Silent_p.L198L	NM_004405	NP_004396			distal-less homeobox 2							nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.216)															---	---	---	---
HOXD12	3238	broad.mit.edu	37	2	176964613	176964613	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:176964613C>T	uc010zev.1	+	1	84	c.84C>T	c.(82-84)AAC>AAT	p.N28N	HOXD12_uc010zew.1_Silent_p.N28N	NM_021193	NP_067016	P35452	HXD12_HUMAN	homeobox D12	28						nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0521)|READ - Rectum adenocarcinoma(9;0.0678)														---	---	---	---
HOXD10	3236	broad.mit.edu	37	2	176981694	176981694	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:176981694A>G	uc002ukj.2	+	1	203	c.133A>G	c.(133-135)ACC>GCC	p.T45A		NM_002148	NP_002139	P28358	HXD10_HUMAN	homeobox D10	45						nucleus	sequence-specific DNA binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0226)|READ - Rectum adenocarcinoma(9;0.0556)														---	---	---	---
HNRNPA3	220988	broad.mit.edu	37	2	178080823	178080823	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:178080823A>G	uc002ulb.1	+	4	566	c.460A>G	c.(460-462)ACC>GCC	p.T154A	HNRNPA3_uc002ulc.1_Missense_Mutation_p.T154A|HNRNPA3_uc002uld.2_Missense_Mutation_p.T132A|HNRNPA3_uc002ule.2_5'Flank	NM_194247	NP_919223	P51991	ROA3_HUMAN	heterogeneous nuclear ribonucleoprotein A3	154	RRM 2.					catalytic step 2 spliceosome|nucleolus|nucleoplasm	nucleotide binding|protein binding|RNA binding			ovary(2)	2																		---	---	---	---
TTN	7273	broad.mit.edu	37	2	179399998	179399998	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179399998T>C	uc010zfg.1	-	307	93864	c.93640A>G	c.(93640-93642)ACC>GCC	p.T31214A	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.T24909A|TTN_uc010zfi.1_Missense_Mutation_p.T24842A|TTN_uc010zfj.1_Missense_Mutation_p.T24717A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	32141							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179407619	179407619	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179407619C>T	uc010zfg.1	-	297	89482	c.89258G>A	c.(89257-89259)GGC>GAC	p.G29753D	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G23448D|TTN_uc010zfi.1_Missense_Mutation_p.G23381D|TTN_uc010zfj.1_Missense_Mutation_p.G23256D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	30680							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179451992	179451992	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179451992C>T	uc010zfg.1	-	256	56466	c.56242G>A	c.(56242-56244)GTT>ATT	p.V18748I	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V12443I|TTN_uc010zfi.1_Missense_Mutation_p.V12376I|TTN_uc010zfj.1_Missense_Mutation_p.V12251I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	19675							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179471746	179471746	+	Splice_Site	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179471746A>G	uc010zfg.1	-	227	46101	c.45877_splice	c.e227+1	p.G15293_splice	uc002ump.1_Intron|TTN_uc010zfh.1_Splice_Site_p.G8988_splice|TTN_uc010zfi.1_Splice_Site_p.G8921_splice|TTN_uc010zfj.1_Splice_Site_p.G8796_splice	NM_133378	NP_596869			titin isoform N2-A								ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179485917	179485917	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179485917T>C	uc010zfg.1	-	195	38048	c.37824A>G	c.(37822-37824)CTA>CTG	p.L12608L	TTN_uc010zfh.1_Silent_p.L6303L|TTN_uc010zfi.1_Silent_p.L6236L|TTN_uc010zfj.1_Silent_p.L6111L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	13535							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179486301	179486301	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179486301T>C	uc010zfg.1	-	194	37770	c.37546A>G	c.(37546-37548)AAG>GAG	p.K12516E	TTN_uc010zfh.1_Missense_Mutation_p.K6211E|TTN_uc010zfi.1_Missense_Mutation_p.K6144E|TTN_uc010zfj.1_Missense_Mutation_p.K6019E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	13443							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179599675	179599675	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179599675T>C	uc010zfg.1	-	48	11468	c.11244A>G	c.(11242-11244)TTA>TTG	p.L3748L	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.L409L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4675							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179614709	179614709	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179614709T>C	uc002unb.2	-	46	12642	c.12418A>G	c.(12418-12420)ACT>GCT	p.T4140A	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179638802	179638802	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179638802G>T	uc010zfg.1	-	31	7317	c.7093C>A	c.(7093-7095)CAA>AAA	p.Q2365K	TTN_uc010zfh.1_Missense_Mutation_p.Q2319K|TTN_uc010zfi.1_Missense_Mutation_p.Q2319K|TTN_uc010zfj.1_Missense_Mutation_p.Q2319K|TTN_uc002unb.2_Missense_Mutation_p.Q2365K|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2365							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
NEUROD1	4760	broad.mit.edu	37	2	182543033	182543033	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:182543033C>T	uc002uof.2	-	2	791	c.555G>A	c.(553-555)GCG>GCA	p.A185A	CERKL_uc002uod.1_Intron	NM_002500	NP_002491	Q13562	NDF1_HUMAN	neurogenic differentiation 1	185				A -> G (in Ref. 2; BAA11558 and 5; BAA87605).	amacrine cell differentiation|cerebellum development|dentate gyrus development|embryonic organ morphogenesis|enteroendocrine cell differentiation|glucose homeostasis|inner ear development|insulin secretion|negative regulation of apoptosis|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of intestinal epithelial structure maintenance|response to glucose stimulus	cytoplasm|nucleus	chromatin binding|E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.088)															---	---	---	---
NCKAP1	10787	broad.mit.edu	37	2	183860523	183860523	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:183860523C>T	uc002upc.2	-	7	1049	c.647G>A	c.(646-648)CGA>CAA	p.R216Q	NCKAP1_uc002upb.2_Missense_Mutation_p.R222Q	NM_013436	NP_038464	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1 isoform 1	216					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)															---	---	---	---
TFPI	7035	broad.mit.edu	37	2	188332652	188332652	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:188332652G>T	uc002upx.2	-	7	669	c.636C>A	c.(634-636)CAC>CAA	p.H212Q	TFPI_uc002upy.2_Missense_Mutation_p.H212Q|TFPI_uc002upz.2_Missense_Mutation_p.H208Q	NM_006287	NP_006278	P10646	TFPI1_HUMAN	tissue factor pathway inhibitor isoform a	212					blood coagulation, extrinsic pathway	extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0554)		Coagulation factor VIIa(DB00036)													---	---	---	---
STAT1	6772	broad.mit.edu	37	2	191862940	191862940	+	Intron	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:191862940T>C	uc002usj.2	-						STAT1_uc010fse.1_Intron|STAT1_uc002usk.2_Intron|STAT1_uc002usl.2_Intron|STAT1_uc010fsf.1_Intron	NM_007315	NP_009330			signal transducer and activator of transcription						activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			lung(3)|breast(3)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)													---	---	---	---
DNAH7	56171	broad.mit.edu	37	2	196746682	196746682	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:196746682A>G	uc002utj.3	-	36	5899	c.5798T>C	c.(5797-5799)TTG>TCG	p.L1933S		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1933					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12																		---	---	---	---
C2orf66	401027	broad.mit.edu	37	2	197672182	197672182	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:197672182A>G	uc002utv.2	-	2	1228	c.339T>C	c.(337-339)AAT>AAC	p.N113N		NM_213608	NP_998773	Q6UXQ4	CB066_HUMAN	hypothetical protein LOC401027 precursor	113						extracellular region					0																		---	---	---	---
CTLA4	1493	broad.mit.edu	37	2	204735621	204735621	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:204735621T>C	uc002vak.1	+	2	579	c.422T>C	c.(421-423)CTG>CCG	p.L141P	CTLA4_uc002val.1_Missense_Mutation_p.L141P|CTLA4_uc010fty.1_Intron|CTLA4_uc010ftz.1_Intron	NM_005214	NP_005205	P16410	CTLA4_HUMAN	cytotoxic T-lymphocyte-associated protein 4	141	Extracellular (Potential).				B cell receptor signaling pathway|immune response|negative regulation of B cell proliferation|negative regulation of regulatory T cell differentiation|positive regulation of apoptosis|response to DNA damage stimulus|T cell costimulation	clathrin-coated endocytic vesicle|external side of plasma membrane|Golgi apparatus|integral to plasma membrane|perinuclear region of cytoplasm					0					Abatacept(DB01281)													---	---	---	---
PARD3B	117583	broad.mit.edu	37	2	206050586	206050586	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:206050586A>G	uc002var.1	+	14	2230	c.2023A>G	c.(2023-2025)AGC>GGC	p.S675G	PARD3B_uc010fub.1_Missense_Mutation_p.S675G|PARD3B_uc002vao.1_Missense_Mutation_p.S675G|PARD3B_uc002vap.1_Missense_Mutation_p.S613G|PARD3B_uc002vaq.1_Missense_Mutation_p.S675G	NM_152526	NP_689739	Q8TEW8	PAR3L_HUMAN	par-3 partitioning defective 3 homolog B isoform	675					cell cycle|cell division	endomembrane system|tight junction				skin(2)|ovary(1)|breast(1)	4		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)														---	---	---	---
INO80D	54891	broad.mit.edu	37	2	206874370	206874370	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:206874370G>A	uc002vaz.3	-	9	2096	c.1691C>T	c.(1690-1692)CCT>CTT	p.P564L		NM_017759	NP_060229	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	564					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1																		---	---	---	---
ZDBF2	57683	broad.mit.edu	37	2	207174184	207174184	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:207174184T>C	uc002vbp.2	+	5	5182	c.4932T>C	c.(4930-4932)GAT>GAC	p.D1644D		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1644							nucleic acid binding|zinc ion binding			ovary(3)	3																		---	---	---	---
ADAM23	8745	broad.mit.edu	37	2	207437886	207437886	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:207437886T>C	uc002vbq.2	+	18	1927	c.1704T>C	c.(1702-1704)GAT>GAC	p.D568D	ADAM23_uc010ziv.1_RNA	NM_003812	NP_003803	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23 preproprotein	568	Disintegrin.|May bind the integrin receptor.|Extracellular (Potential).				cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)														---	---	---	---
FAM119A	151194	broad.mit.edu	37	2	208486582	208486582	+	Silent	SNP	G	A	A	rs150521439		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:208486582G>A	uc002vcf.2	-	3	367	c.207C>T	c.(205-207)GCC>GCT	p.A69A	FAM119A_uc002vce.2_Silent_p.A69A|FAM119A_uc010fuk.1_Silent_p.A69A|FAM119A_uc002vcg.3_Silent_p.A69A	NM_145280	NP_660323	Q8WXB1	MT21A_HUMAN	hypothetical protein LOC151194	69						integral to membrane	methyltransferase activity				0				LUSC - Lung squamous cell carcinoma(261;0.0705)|Epithelial(149;0.131)|Lung(261;0.135)														---	---	---	---
IKZF2	22807	broad.mit.edu	37	2	213872794	213872794	+	Nonsense_Mutation	SNP	G	A	A	rs146574423		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:213872794G>A	uc002vem.2	-	8	1040	c.871C>T	c.(871-873)CGA>TGA	p.R291*	IKZF2_uc010fuu.2_Nonsense_Mutation_p.R146*|IKZF2_uc002vej.2_Nonsense_Mutation_p.R238*|IKZF2_uc002vek.2_RNA|IKZF2_uc010fuv.2_Nonsense_Mutation_p.R217*|IKZF2_uc002vel.2_Nonsense_Mutation_p.R212*|IKZF2_uc010fuw.2_Nonsense_Mutation_p.R65*|IKZF2_uc010fux.2_Nonsense_Mutation_p.R65*|IKZF2_uc010fuy.2_Nonsense_Mutation_p.R219*|IKZF2_uc002ven.2_Nonsense_Mutation_p.R265*|IKZF2_uc002vei.2_Nonsense_Mutation_p.R69*	NM_016260	NP_057344	Q9UKS7	IKZF2_HUMAN	helios isoform 1	291					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)														---	---	---	---
SMARCAL1	50485	broad.mit.edu	37	2	217332655	217332655	+	Intron	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:217332655T>C	uc002vgc.3	+						SMARCAL1_uc010fvf.2_Intron|SMARCAL1_uc002vgd.3_Intron|SMARCAL1_uc010fvg.2_Intron	NM_014140	NP_054859			SWI/SNF-related matrix-associated						chromatin modification|DNA metabolic process|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity			ovary(3)|breast(3)|skin(1)	7		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)										Schimke_Immuno-Osseous_Dysplasia				---	---	---	---
TNS1	7145	broad.mit.edu	37	2	218673324	218673324	+	Splice_Site	SNP	A	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:218673324A>T	uc002vgt.2	-	31	5428	c.5030_splice	c.e31+1	p.K1677_splice	TNS1_uc002vgr.2_Splice_Site_p.K1663_splice|TNS1_uc002vgs.2_Splice_Site_p.K1656_splice|TNS1_uc002vgq.2_Splice_Site_p.K177_splice	NM_022648	NP_072174			tensin							cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)														---	---	---	---
TNS1	7145	broad.mit.edu	37	2	218682650	218682650	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:218682650T>G	uc002vgt.2	-	24	4491	c.4093A>C	c.(4093-4095)AGC>CGC	p.S1365R	TNS1_uc002vgr.2_Missense_Mutation_p.S1352R|TNS1_uc002vgs.2_Missense_Mutation_p.S1344R|TNS1_uc010zjv.1_Missense_Mutation_p.S1344R	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	1365						cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)														---	---	---	---
TNS1	7145	broad.mit.edu	37	2	218682831	218682831	+	Silent	SNP	G	A	A	rs149340421	byFrequency	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:218682831G>A	uc002vgt.2	-	24	4310	c.3912C>T	c.(3910-3912)CTC>CTT	p.L1304L	TNS1_uc002vgr.2_Silent_p.L1291L|TNS1_uc002vgs.2_Silent_p.L1283L|TNS1_uc010zjv.1_Silent_p.L1283L	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	1304						cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)														---	---	---	---
RNF25	64320	broad.mit.edu	37	2	219528977	219528977	+	Silent	SNP	G	A	A	rs148126928		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:219528977G>A	uc002vit.2	-	10	1171	c.1083C>T	c.(1081-1083)CAC>CAT	p.H361H	RNF25_uc010fvw.2_Silent_p.H249H	NM_022453	NP_071898	Q96BH1	RNF25_HUMAN	ring finger protein 25	361					positive regulation of NF-kappaB transcription factor activity	cytosol|nucleus	NF-kappaB binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Renal(207;0.0474)		Epithelial(149;6.99e-07)|all cancers(144;0.000129)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)														---	---	---	---
STK36	27148	broad.mit.edu	37	2	219559251	219559251	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:219559251G>A	uc002viu.2	+	21	2670	c.2404G>A	c.(2404-2406)GCA>ACA	p.A802T	STK36_uc002viv.2_Missense_Mutation_p.A802T|STK36_uc002viw.2_5'UTR|STK36_uc002vix.2_5'Flank	NM_015690	NP_056505	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	802					cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			ovary(4)|stomach(2)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	11		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)														---	---	---	---
STK36	27148	broad.mit.edu	37	2	219561249	219561249	+	Splice_Site	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:219561249G>T	uc002viu.2	+	22	2778	c.2512_splice	c.e22-1	p.V838_splice	STK36_uc002viv.2_Intron|STK36_uc002viw.2_Splice_Site_p.V17_splice|STK36_uc002vix.2_5'Flank	NM_015690	NP_056505			serine/threonine kinase 36						cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			ovary(4)|stomach(2)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	11		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)														---	---	---	---
CRYBA2	1412	broad.mit.edu	37	2	219856929	219856929	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:219856929C>T	uc002vjj.1	-	3	233	c.198G>A	c.(196-198)CAG>CAA	p.Q66Q	CRYBA2_uc002vjk.1_Silent_p.Q66Q	NM_057094	NP_476435	P53672	CRBA2_HUMAN	crystallin, beta A2	66	Beta/gamma crystallin 'Greek key' 2.						structural constituent of eye lens				0		Renal(207;0.0474)		Epithelial(149;9.77e-07)|all cancers(144;0.000167)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)														---	---	---	---
ATG9A	79065	broad.mit.edu	37	2	220092657	220092657	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:220092657G>T	uc002vke.1	-	3	276	c.90C>A	c.(88-90)GCC>GCA	p.A30A	ATG9A_uc002vkd.1_5'Flank|ATG9A_uc002vkf.1_Silent_p.A30A|ANKZF1_uc010zkv.1_5'Flank|ANKZF1_uc010zkw.1_5'Flank|ANKZF1_uc002vkg.2_5'Flank|ANKZF1_uc002vkh.2_5'Flank|ANKZF1_uc002vki.2_5'Flank|ANKZF1_uc002vkj.1_5'Flank	NM_001077198	NP_001070666	Q7Z3C6	ATG9A_HUMAN	APG9 autophagy 9-like 1	30	Cytoplasmic (By similarity).				autophagic vacuole assembly|protein transport	autophagic vacuole membrane|cytoplasmic vesicle|Golgi apparatus|integral to membrane|late endosome membrane				skin(1)	1		Renal(207;0.0474)		Epithelial(149;1.37e-06)|all cancers(144;0.000222)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)														---	---	---	---
MOGAT1	116255	broad.mit.edu	37	2	223553067	223553067	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:223553067G>A	uc010fws.1	+	2	147	c.99G>A	c.(97-99)CCG>CCA	p.P33P	MOGAT1_uc010fwt.1_5'UTR	NM_058165	NP_477513	Q96PD6	MOGT1_HUMAN	monoacylglycerol O-acyltransferase 1	33	Helical; (Potential).				glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			breast(1)	1		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;2.06e-07)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0105)														---	---	---	---
SERPINE2	5270	broad.mit.edu	37	2	224842297	224842297	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:224842297T>C	uc002vnu.2	-	8	1366	c.1123A>G	c.(1123-1125)AGA>GGA	p.R375G	SERPINE2_uc002vnt.2_Missense_Mutation_p.R374G|SERPINE2_uc010zlr.1_Missense_Mutation_p.R386G|SERPINE2_uc002vnv.2_Missense_Mutation_p.R374G	NM_006216	NP_006207	P07093	GDN_HUMAN	plasminogen activator inhibitor type 1, member 2	375					negative regulation of blood coagulation|negative regulation of plasminogen activation|negative regulation of platelet aggregation|positive regulation of astrocyte differentiation|regulation of cell migration	cytosol|extracellular matrix|extracellular space|extrinsic to external side of plasma membrane|neuromuscular junction|platelet alpha granule	heparin binding|receptor binding|serine-type endopeptidase inhibitor activity			breast(2)|ovary(1)|central_nervous_system(1)	4		Renal(207;0.025)|all_lung(227;0.0586)|Lung NSC(271;0.0682)|all_hematologic(139;0.0797)		Epithelial(121;5.68e-10)|all cancers(144;1.9e-07)|Lung(261;0.0088)|LUSC - Lung squamous cell carcinoma(224;0.00902)														---	---	---	---
CUL3	8452	broad.mit.edu	37	2	225360635	225360635	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:225360635T>C	uc002vny.2	-	13	2140	c.1756A>G	c.(1756-1758)AAT>GAT	p.N586D	CUL3_uc010zls.1_Missense_Mutation_p.N520D|CUL3_uc010fwy.1_Missense_Mutation_p.N592D|CUL3_uc002vnz.1_Missense_Mutation_p.N33D	NM_003590	NP_003581	Q13618	CUL3_HUMAN	cullin 3	586					cell cycle arrest|cell migration|cyclin catabolic process|cytokinesis|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|mitotic anaphase|negative regulation of Rho protein signal transduction|positive regulation of cell proliferation|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|Golgi apparatus|nucleus|polar microtubule	ubiquitin protein ligase binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|kidney(1)	4		all_lung(227;0.00877)|Lung NSC(271;0.011)|Renal(207;0.0112)|all_hematologic(139;0.138)		Epithelial(121;1.58e-11)|all cancers(144;1.43e-08)|Lung(261;0.00863)|LUSC - Lung squamous cell carcinoma(224;0.00902)														---	---	---	---
TRIP12	9320	broad.mit.edu	37	2	230723776	230723776	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:230723776A>G	uc002vpw.1	-	3	722	c.613T>C	c.(613-615)TCG>CCG	p.S205P	TRIP12_uc002vpx.1_Missense_Mutation_p.S247P|TRIP12_uc002vpy.1_Intron|TRIP12_uc010zlz.1_RNA|TRIP12_uc010fxh.1_Missense_Mutation_p.S205P	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	205					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)														---	---	---	---
SP140	11262	broad.mit.edu	37	2	231106186	231106186	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:231106186A>G	uc002vql.2	+	4	589	c.474A>G	c.(472-474)CTA>CTG	p.L158L	SP140_uc010zma.1_RNA|SP140_uc002vqk.2_Silent_p.L158L|SP140_uc002vqn.2_Silent_p.L158L|SP140_uc002vqm.2_Silent_p.L158L|SP140_uc010fxl.2_Silent_p.L158L	NM_007237	NP_009168	Q13342	LY10_HUMAN	SP140 nuclear body protein isoform 1	158					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)														---	---	---	---
C2orf57	165100	broad.mit.edu	37	2	232458157	232458157	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:232458157G>A	uc002vrz.2	+	1	546	c.495G>A	c.(493-495)CAG>CAA	p.Q165Q		NM_152614	NP_689827	Q53QW1	CB057_HUMAN	hypothetical protein LOC165100	165										ovary(1)	1		Renal(207;0.025)|all_hematologic(139;0.0735)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;1.33e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.014)														---	---	---	---
CHRND	1144	broad.mit.edu	37	2	233392150	233392150	+	Nonsense_Mutation	SNP	G	T	T	rs121909504		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:233392150G>T	uc002vsw.2	+	3	242	c.238G>T	c.(238-240)GAG>TAG	p.E80*	CHRND_uc010zmg.1_Intron|CHRND_uc010fyc.2_5'UTR|CHRND_uc010zmh.1_5'UTR	NM_000751	NP_000742	Q07001	ACHD_HUMAN	nicotinic acetylcholine receptor delta	80	Extracellular (Potential).		E -> K (in FCCMS; reduced adult and fetal AChR expression and a reduced probability of both adult and fetal AChR being in the open state).		muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)|breast(1)|skin(1)	3		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)														---	---	---	---
TRPM8	79054	broad.mit.edu	37	2	234835246	234835246	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:234835246C>T	uc002vvh.2	+	2	104	c.64C>T	c.(64-66)CGG>TGG	p.R22W	TRPM8_uc010fyj.2_5'UTR	NM_024080	NP_076985	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel,	22	Cytoplasmic (Potential).					integral to membrane				skin(4)	4		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)													---	---	---	---
AGAP1	116987	broad.mit.edu	37	2	237029052	237029052	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:237029052C>T	uc002vvs.2	+	17	2926	c.2331C>T	c.(2329-2331)TGC>TGT	p.C777C	AGAP1_uc002vvt.2_Silent_p.C724C	NM_001037131	NP_001032208	Q9UPQ3	AGAP1_HUMAN	centaurin, gamma 2 isoform 1	777	ANK 1.				protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm	ARF GTPase activator activity|GTP binding|zinc ion binding			ovary(2)|skin(1)	3																		---	---	---	---
GBX2	2637	broad.mit.edu	37	2	237076619	237076619	+	5'UTR	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:237076619G>A	uc002vvw.1	-	1					GBX2_uc010zng.1_5'UTR	NM_001485	NP_001476			gastrulation brain homeo box 2							nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		Breast(86;0.00235)|Renal(207;0.00339)|all_hematologic(139;0.00357)|all_lung(227;0.0616)|Acute lymphoblastic leukemia(138;0.0775)|Ovarian(221;0.089)|Lung NSC(271;0.179)		Epithelial(121;4.5e-25)|OV - Ovarian serous cystadenocarcinoma(60;5.16e-11)|BRCA - Breast invasive adenocarcinoma(100;3.4e-05)|Lung(119;0.00195)|LUSC - Lung squamous cell carcinoma(224;0.00471)														---	---	---	---
HDAC4	9759	broad.mit.edu	37	2	240029856	240029856	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:240029856G>C	uc002vyk.3	-	15	2779	c.1987C>G	c.(1987-1989)CTG>GTG	p.L663V	HDAC4_uc010fyz.1_Missense_Mutation_p.L658V|HDAC4_uc010zoa.1_Missense_Mutation_p.L663V|HDAC4_uc010fza.2_Missense_Mutation_p.L668V|HDAC4_uc010fyy.2_Missense_Mutation_p.L620V|HDAC4_uc010znz.1_Missense_Mutation_p.L546V	NM_006037	NP_006028	P56524	HDAC4_HUMAN	histone deacetylase 4	663	Histone deacetylase.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			breast(3)|skin(2)|ovary(1)	6		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)														---	---	---	---
HDAC4	9759	broad.mit.edu	37	2	240048352	240048352	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:240048352C>T	uc002vyk.3	-	12	2110	c.1318G>A	c.(1318-1320)GCA>ACA	p.A440T	HDAC4_uc010fyz.1_Missense_Mutation_p.A435T|HDAC4_uc010zoa.1_Missense_Mutation_p.A440T|HDAC4_uc010fza.2_Missense_Mutation_p.A445T|HDAC4_uc010fyy.2_Missense_Mutation_p.A397T|HDAC4_uc010znz.1_Missense_Mutation_p.A323T|HDAC4_uc010fzb.1_RNA	NM_006037	NP_006028	P56524	HDAC4_HUMAN	histone deacetylase 4	440					B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			breast(3)|skin(2)|ovary(1)	6		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)														---	---	---	---
NDUFA10	4705	broad.mit.edu	37	2	240954271	240954271	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:240954271T>C	uc002vyn.2	-	5	634	c.554A>G	c.(553-555)GAC>GGC	p.D185G	NDUFA10_uc010fzc.1_Missense_Mutation_p.D225G|NDUFA10_uc002vyo.1_Missense_Mutation_p.D185G	NM_004544	NP_004535	O95299	NDUAA_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	185					mitochondrial electron transport, NADH to ubiquinone|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transport	mitochondrial matrix|mitochondrial respiratory chain complex I	ATP binding|NADH dehydrogenase (ubiquinone) activity|phosphotransferase activity, alcohol group as acceptor			central_nervous_system(1)	1		all_epithelial(40;4.26e-15)|Breast(86;4.4e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0396)|Lung NSC(271;0.128)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(121;7.82e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.5e-13)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;2.39e-05)|Lung(119;0.00519)|LUSC - Lung squamous cell carcinoma(224;0.0202)	NADH(DB00157)													---	---	---	---
Unknown	0	broad.mit.edu	37	2	241065974	241065974	+	IGR	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:241065974T>C								OR6B3 (80485 upstream) : MYEOV2 (6 downstream)																																			---	---	---	---
RNPEPL1	57140	broad.mit.edu	37	2	241516004	241516004	+	Silent	SNP	G	A	A	rs139086666		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:241516004G>A	uc002vzi.2	+	9	1463	c.870G>A	c.(868-870)CCG>CCA	p.P290P	RNPEPL1_uc010fzf.2_Silent_p.P196P|RNPEPL1_uc002vzj.2_5'UTR	NM_018226	NP_060696	Q9HAU8	RNPL1_HUMAN	arginyl aminopeptidase (aminopeptidase B)-like	290					leukotriene biosynthetic process|proteolysis		aminopeptidase activity|metallopeptidase activity|zinc ion binding			large_intestine(1)|skin(1)	2		all_epithelial(40;1.13e-11)|Breast(86;0.000169)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.204)|Melanoma(123;0.238)		Epithelial(32;3.05e-31)|all cancers(36;8.2e-29)|OV - Ovarian serous cystadenocarcinoma(60;8.55e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.12e-06)|Lung(119;0.00168)|Colorectal(34;0.005)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.0322)														---	---	---	---
KIF1A	547	broad.mit.edu	37	2	241683449	241683449	+	Missense_Mutation	SNP	A	G	G	rs35698242		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:241683449A>G	uc002vzy.2	-	31	3337	c.3191T>C	c.(3190-3192)ATT>ACT	p.I1064T	KIF1A_uc010fzk.2_Missense_Mutation_p.I1165T|KIF1A_uc002vzz.1_Missense_Mutation_p.I1165T	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	1064					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)														---	---	---	---
HDLBP	3069	broad.mit.edu	37	2	242176107	242176107	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:242176107C>T	uc002waz.2	-	21	3055	c.2827G>A	c.(2827-2829)GGC>AGC	p.G943S	HDLBP_uc002wba.2_Missense_Mutation_p.G943S|HDLBP_uc002wbb.2_Missense_Mutation_p.G895S	NM_203346	NP_976221	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	943	KH 11.				cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(3)|skin(1)	4		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)														---	---	---	---
C2orf85	285093	broad.mit.edu	37	2	242815392	242815392	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:242815392G>A	uc010fzu.1	+	2	1708	c.1685G>A	c.(1684-1686)CGG>CAG	p.R562Q		NM_173821	NP_776182	Q14D33	CB085_HUMAN	hypothetical protein LOC285093	562						integral to membrane				ovary(1)	1																		---	---	---	---
CRELD1	78987	broad.mit.edu	37	3	9979713	9979713	+	Missense_Mutation	SNP	C	T	T	rs2302787	byFrequency;by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:9979713C>T	uc003bug.2	+	5	501	c.383C>T	c.(382-384)CCG>CTG	p.P128L	CIDEC_uc003bto.2_Intron|CRELD1_uc003buf.2_Missense_Mutation_p.P128L|CRELD1_uc003buh.2_Missense_Mutation_p.P128L|CRELD1_uc003bui.2_Missense_Mutation_p.P128L|CRELD1_uc003buj.2_RNA	NM_001077415	NP_001070883	Q96HD1	CREL1_HUMAN	cysteine-rich with EGF-like domains 1 isoform 3	128	Extracellular (Potential).				cardiac septum development|endocardial cushion development	integral to membrane	calcium ion binding			ovary(1)	1																		---	---	---	---
ATP2B2	491	broad.mit.edu	37	3	10452437	10452437	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:10452437G>A	uc003bvt.2	-	3	701	c.262C>T	c.(262-264)CCT>TCT	p.P88S	ATP2B2_uc003bvv.2_Missense_Mutation_p.P88S|ATP2B2_uc003bvw.2_Missense_Mutation_p.P88S|ATP2B2_uc010hdp.2_Missense_Mutation_p.P88S|ATP2B2_uc010hdo.2_5'UTR	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	88	Cytoplasmic (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6																		---	---	---	---
TBC1D5	9779	broad.mit.edu	37	3	17208262	17208262	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:17208262T>C	uc003cbf.2	-	21	3756	c.2091A>G	c.(2089-2091)AAA>AAG	p.K697K	TBC1D5_uc010heu.2_Silent_p.K284K|TBC1D5_uc010hev.2_Silent_p.K719K|TBC1D5_uc003cbe.2_Silent_p.K697K	NM_014744	NP_055559	Q92609	TBCD5_HUMAN	TBC1 domain family, member 5 isoform b	697						intracellular	protein binding|Rab GTPase activator activity			ovary(1)	1																		---	---	---	---
KCNH8	131096	broad.mit.edu	37	3	19190227	19190227	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:19190227G>T	uc003cbk.1	+	1	211	c.16G>T	c.(16-18)GGA>TGA	p.G6*	KCNH8_uc011awe.1_Nonsense_Mutation_p.G6*|KCNH8_uc010hex.1_Translation_Start_Site	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	6	Cytoplasmic (Potential).					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5																		---	---	---	---
EFHB	151651	broad.mit.edu	37	3	19974823	19974823	+	Silent	SNP	T	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:19974823T>G	uc003cbl.3	-	1	884	c.688A>C	c.(688-690)AGA>CGA	p.R230R	EFHB_uc003cbm.2_Silent_p.R100R	NM_144715	NP_653316	Q8N7U6	EFHB_HUMAN	EF hand domain family, member B	230					signal transduction	proteinaceous extracellular matrix	calcium ion binding				0																		---	---	---	---
THRB	7068	broad.mit.edu	37	3	24185077	24185077	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:24185077T>C	uc003ccx.3	-	8	1002	c.653A>G	c.(652-654)GAA>GGA	p.E218G	THRB_uc010hfe.2_Missense_Mutation_p.E218G|THRB_uc003ccy.3_Missense_Mutation_p.E218G|THRB_uc003ccz.3_Missense_Mutation_p.E213G	NM_001128176	NP_001121648	P10828	THB_HUMAN	thyroid hormone receptor, beta	218					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	enzyme binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription corepressor activity|zinc ion binding			skin(2)|pancreas(1)	3					Levothyroxine(DB00451)|Liothyronine(DB00279)													---	---	---	---
STT3B	201595	broad.mit.edu	37	3	31658571	31658571	+	Intron	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:31658571C>T	uc011axe.1	+						STT3B_uc010hft.1_Intron|STT3B_uc003cer.1_Intron|STT3B_uc003cet.2_Intron	NM_178862	NP_849193			source of immunodominant MHC-associated						protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding				0																		---	---	---	---
TRANK1	9881	broad.mit.edu	37	3	36873314	36873314	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:36873314C>T	uc003cgj.2	-	12	6280	c.5978G>A	c.(5977-5979)CGC>CAC	p.R1993H		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	2543					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
TRANK1	9881	broad.mit.edu	37	3	36875321	36875321	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:36875321T>A	uc003cgj.2	-	12	4273	c.3971A>T	c.(3970-3972)TAT>TTT	p.Y1324F		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	1874					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
DLEC1	9940	broad.mit.edu	37	3	38139378	38139378	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:38139378G>T	uc003cho.1	+	18	2730	c.2709G>T	c.(2707-2709)CAG>CAT	p.Q903H	DLEC1_uc003chp.1_Missense_Mutation_p.Q903H|DLEC1_uc010hgv.1_Missense_Mutation_p.Q903H|DLEC1_uc003chr.1_Missense_Mutation_p.Q9H|DLEC1_uc010hgx.1_RNA	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	903					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)														---	---	---	---
OXSR1	9943	broad.mit.edu	37	3	38287635	38287635	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:38287635C>T	uc003chy.2	+	13	1522	c.1180C>T	c.(1180-1182)CAG>TAG	p.Q394*	OXSR1_uc010hhb.2_Nonsense_Mutation_p.Q328*	NM_005109	NP_005100	O95747	OXSR1_HUMAN	oxidative-stress responsive 1	394					intracellular protein kinase cascade|response to oxidative stress		ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)														---	---	---	---
WDR48	57599	broad.mit.edu	37	3	39107318	39107318	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:39107318C>T	uc003cit.2	+	3	216	c.206C>T	c.(205-207)GCA>GTA	p.A69V	WDR48_uc011ayt.1_Missense_Mutation_p.A69V|WDR48_uc011ayu.1_Intron|WDR48_uc011ayv.1_Intron|WDR48_uc003ciu.2_RNA	NM_020839	NP_065890	Q8TAF3	WDR48_HUMAN	WD repeat domain 48	69					interspecies interaction between organisms|protein deubiquitination	lysosome|nucleus	protein binding			ovary(1)|breast(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)														---	---	---	---
ZNF620	253639	broad.mit.edu	37	3	40557593	40557593	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:40557593T>C	uc003ckk.2	+	5	657	c.508T>C	c.(508-510)TTT>CTT	p.F170L	ZNF620_uc003ckl.2_Missense_Mutation_p.F56L	NM_175888	NP_787084	Q6ZNG0	ZN620_HUMAN	zinc finger protein 620	170					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0519)|Kidney(284;0.0653)														---	---	---	---
C3orf39	84892	broad.mit.edu	37	3	43122150	43122150	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:43122150G>A	uc003cmq.1	-	2	915	c.774C>T	c.(772-774)CTC>CTT	p.L258L	C3orf39_uc003cmr.1_Silent_p.L258L	NM_032806	NP_116195	Q8NAT1	AGO61_HUMAN	glycosyltransferase precursor	258						extracellular region	transferase activity, transferring glycosyl groups			ovary(1)|skin(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0571)|Kidney(284;0.0718)														---	---	---	---
C3orf23	285343	broad.mit.edu	37	3	44434452	44434452	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:44434452G>T	uc010him.2	+	6	923	c.678G>T	c.(676-678)TTG>TTT	p.L226F	C3orf23_uc003cnd.3_Missense_Mutation_p.L226F|C3orf23_uc003cne.3_Missense_Mutation_p.L82F	NM_173826	NP_776187	Q8N3R3	CC023_HUMAN	hypothetical protein LOC285343 isoform 1	226						mitochondrion				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(197;0.0468)|Kidney(197;0.0585)														---	---	---	---
C3orf23	285343	broad.mit.edu	37	3	44434453	44434453	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:44434453C>T	uc010him.2	+	6	924	c.679C>T	c.(679-681)CAA>TAA	p.Q227*	C3orf23_uc003cnd.3_Nonsense_Mutation_p.Q227*|C3orf23_uc003cne.3_Nonsense_Mutation_p.Q83*	NM_173826	NP_776187	Q8N3R3	CC023_HUMAN	hypothetical protein LOC285343 isoform 1	227						mitochondrion				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(197;0.0468)|Kidney(197;0.0585)														---	---	---	---
ZNF197	10168	broad.mit.edu	37	3	44683855	44683855	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:44683855G>A	uc003cnm.2	+	6	1439	c.1233G>A	c.(1231-1233)TCG>TCA	p.S411S	ZNF197_uc003cnn.2_Intron|ZNF197_uc003cno.2_Intron|ZNF197_uc003cnp.2_Intron	NM_006991	NP_008922	O14709	ZN197_HUMAN	zinc finger protein 197 isoform 1	411	C2H2-type 2.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|skin(1)	4				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)														---	---	---	---
ZNF197	10168	broad.mit.edu	37	3	44684845	44684845	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:44684845G>T	uc003cnm.2	+	6	2429	c.2223G>T	c.(2221-2223)AAG>AAT	p.K741N	ZNF197_uc003cnn.2_Intron|ZNF197_uc003cno.2_Intron|ZNF197_uc003cnp.2_Intron	NM_006991	NP_008922	O14709	ZN197_HUMAN	zinc finger protein 197 isoform 1	741	C2H2-type 14.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|skin(1)	4				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)														---	---	---	---
ZNF502	91392	broad.mit.edu	37	3	44762936	44762936	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:44762936A>G	uc011baa.1	+	4	882	c.627A>G	c.(625-627)AAA>AAG	p.K209K	ZNF502_uc003cns.2_Silent_p.K209K|ZNF502_uc011bab.1_Silent_p.K209K|ZNF502_uc003cnt.2_Silent_p.K209K	NM_001134440	NP_001127912	Q8TBZ5	ZN502_HUMAN	zinc finger protein 502	209					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00855)|KIRC - Kidney renal clear cell carcinoma(197;0.0471)|Kidney(197;0.0589)														---	---	---	---
SMARCC1	6599	broad.mit.edu	37	3	47719787	47719787	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:47719787C>T	uc003crq.2	-	16	1590	c.1472G>A	c.(1471-1473)CGA>CAA	p.R491Q	SMARCC1_uc011bbc.1_RNA|SMARCC1_uc011bbd.1_Missense_Mutation_p.R382Q	NM_003074	NP_003065	Q92922	SMRC1_HUMAN	SWI/SNF-related matrix-associated	491	SWIRM.				chromatin remodeling|nervous system development|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex|WINAC complex	DNA binding|protein N-terminus binding|transcription coactivator activity			skin(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;7.47e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)														---	---	---	---
SMARCC1	6599	broad.mit.edu	37	3	47721922	47721922	+	Intron	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:47721922C>A	uc003crq.2	-						SMARCC1_uc011bbc.1_Intron|SMARCC1_uc011bbd.1_Intron	NM_003074	NP_003065			SWI/SNF-related matrix-associated						chromatin remodeling|nervous system development|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex|WINAC complex	DNA binding|protein N-terminus binding|transcription coactivator activity			skin(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;7.47e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)														---	---	---	---
DHX30	22907	broad.mit.edu	37	3	47888976	47888976	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:47888976G>A	uc003cru.2	+	13	2486	c.2060G>A	c.(2059-2061)CGC>CAC	p.R687H	DHX30_uc003crt.2_Missense_Mutation_p.R648H|MIR1226_hsa-mir-1226|MI0006313_5'Flank	NM_138615	NP_619520	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 30	687	Helicase C-terminal.					mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)														---	---	---	---
MIR1226	100302232	broad.mit.edu	37	3	47891116	47891116	+	RNA	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:47891116C>A	hsa-mir-1226|MI0006313	+			c.72C>A			DHX30_uc003crt.2_Intron|DHX30_uc003cru.2_Intron																	0																		---	---	---	---
COL7A1	1294	broad.mit.edu	37	3	48628108	48628108	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:48628108C>T	uc003ctz.2	-	13	1779	c.1778G>A	c.(1777-1779)CGG>CAG	p.R593Q		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	593	Fibronectin type-III 4.|Nonhelical region (NC1).				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)														---	---	---	---
COL7A1	1294	broad.mit.edu	37	3	48631901	48631901	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:48631901C>T	uc003ctz.2	-	2	167	c.166G>A	c.(166-168)GAG>AAG	p.E56K		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	56	Nonhelical region (NC1).|VWFA 1.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)														---	---	---	---
UQCRC1	7384	broad.mit.edu	37	3	48636573	48636573	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:48636573C>T	uc003cub.1	-	13	1476	c.1431G>A	c.(1429-1431)TGG>TGA	p.W477*	UQCRC1_uc003cua.1_Nonsense_Mutation_p.W362*|UQCRC1_uc003cuc.1_Nonsense_Mutation_p.W478*|UQCRC1_uc003cud.1_Nonsense_Mutation_p.W476*	NM_003365	NP_003356	P31930	QCR1_HUMAN	ubiquinol-cytochrome c reductase core protein I	477					aerobic respiration|proteolysis		metalloendopeptidase activity|ubiquinol-cytochrome-c reductase activity|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)	Atovaquone(DB01117)													---	---	---	---
CELSR3	1951	broad.mit.edu	37	3	48677916	48677916	+	Silent	SNP	T	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:48677916T>G	uc003cul.2	-	34	9383	c.9102A>C	c.(9100-9102)GCA>GCC	p.A3034A	CELSR3_uc003cuf.1_Silent_p.A3132A|CELSR3_uc010hkf.2_Silent_p.A324A|CELSR3_uc010hkg.2_Silent_p.A1017A	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	3034	Cytoplasmic (Potential).				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)														---	---	---	---
AMT	275	broad.mit.edu	37	3	49459855	49459855	+	Missense_Mutation	SNP	C	T	T	rs150649086		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49459855C>T	uc003cww.2	-	1	158	c.29G>A	c.(28-30)CGT>CAT	p.R10H	AMT_uc011bcn.1_5'UTR|AMT_uc003cwx.2_Missense_Mutation_p.R10H|AMT_uc011bco.1_Missense_Mutation_p.R10H|AMT_uc003cwy.2_5'UTR|AMT_uc011bcp.1_5'UTR|AMT_uc011bcq.1_Missense_Mutation_p.R10H|NICN1_uc003cwz.1_3'UTR	NM_000481	NP_000472	P48728	GCST_HUMAN	aminomethyltransferase isoform 1 precursor	10					glycine catabolic process	mitochondrion	aminomethyltransferase activity|transaminase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)													---	---	---	---
BSN	8927	broad.mit.edu	37	3	49700719	49700719	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49700719C>A	uc003cxe.3	+	7	11242	c.11128C>A	c.(11128-11130)CGT>AGT	p.R3710S		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	3710					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)														---	---	---	---
RNF123	63891	broad.mit.edu	37	3	49736480	49736480	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49736480G>A	uc003cxh.2	+	10	792	c.706G>A	c.(706-708)GCC>ACC	p.A236T	RNF123_uc010hky.1_5'Flank|RNF123_uc003cxi.2_5'Flank	NM_022064	NP_071347	Q5XPI4	RN123_HUMAN	ring finger protein 123	236	B30.2/SPRY.					cytoplasm	ligase activity|protein binding|zinc ion binding			kidney(3)|ovary(1)|lung(1)|breast(1)|skin(1)	7				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)														---	---	---	---
C3orf54	389119	broad.mit.edu	37	3	49842011	49842011	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49842011G>A	uc003cxq.1	+	2	588	c.455G>A	c.(454-456)CGG>CAG	p.R152Q		NM_203370	NP_976248	Q96EL1	CC054_HUMAN	hypothetical protein LOC389119	150											0				BRCA - Breast invasive adenocarcinoma(193;3.55e-06)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)														---	---	---	---
GNAI2	2771	broad.mit.edu	37	3	50293689	50293689	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:50293689G>A	uc003cyq.1	+	5	651	c.530G>A	c.(529-531)CGG>CAG	p.R177Q	GNAI2_uc003cyo.1_Missense_Mutation_p.R161Q|GNAI2_uc003cyp.1_Missense_Mutation_p.R161Q|GNAI2_uc010hlg.1_Missense_Mutation_p.R96Q|GNAI2_uc011bdn.1_Missense_Mutation_p.R140Q|GNAI2_uc003cyr.1_Missense_Mutation_p.R96Q	NM_002070	NP_002061	P04899	GNAI2_HUMAN	guanine nucleotide binding protein (G protein),	177	GTP (By similarity).				adenosine receptor signaling pathway|cell cycle|cell division|gamma-aminobutyric acid signaling pathway|inhibition of adenylate cyclase activity by G-protein signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|platelet activation|response to nutrient|synaptic transmission	centrosome|heterotrimeric G-protein complex|midbody	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000288)|KIRC - Kidney renal clear cell carcinoma(197;0.00571)|Kidney(197;0.00651)														---	---	---	---
C3orf45	132228	broad.mit.edu	37	3	50316562	50316562	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:50316562C>T	uc003cyz.2	+	1	45	c.18C>T	c.(16-18)CCC>CCT	p.P6P		NM_153215	NP_694947	Q8N112	CC045_HUMAN	hypothetical protein LOC132228	6						integral to membrane				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)														---	---	---	---
RASSF1	11186	broad.mit.edu	37	3	50374740	50374740	+	Intron	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:50374740G>A	uc003dad.1	-						RASSF1_uc003dab.1_Missense_Mutation_p.A4V|RASSF1_uc003dac.2_Intron|RASSF1_uc003dae.1_Intron|RASSF1_uc010hlk.1_Intron|RASSF1_uc003daf.1_Intron|RASSF1_uc011bdq.1_3'UTR	NM_170714	NP_733832			Ras association domain family 1 isoform D						cell cycle arrest|negative regulation of cell cycle arrest|positive regulation of protein ubiquitination|protein stabilization|Ras protein signal transduction|response to DNA damage stimulus	microtubule|microtubule cytoskeleton|microtubule organizing center|nucleus|spindle pole	identical protein binding|protein binding|protein N-terminus binding|zinc ion binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000278)|OV - Ovarian serous cystadenocarcinoma(275;0.0015)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)														---	---	---	---
MAPKAPK3	7867	broad.mit.edu	37	3	50683670	50683670	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:50683670T>C	uc003day.1	+	10	1400	c.804T>C	c.(802-804)CCT>CCC	p.P268P	MAPKAPK3_uc003daz.1_Silent_p.P268P|MAPKAPK3_uc003dba.1_Silent_p.P268P|MAPKAPK3_uc010hlr.1_Silent_p.P268P	NM_004635	NP_004626	Q16644	MAPK3_HUMAN	mitogen-activated protein kinase-activated	268	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.0188)|Kidney(197;0.0223)														---	---	---	---
RBM15B	29890	broad.mit.edu	37	3	51430939	51430939	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:51430939C>T	uc003dbd.2	+	1	2209	c.2109C>T	c.(2107-2109)CAC>CAT	p.H703H		NM_013286	NP_037418	Q8NDT2	RB15B_HUMAN	RNA binding motif protein 15B	703					interspecies interaction between organisms|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nucleoplasm	nucleotide binding|protein binding|RNA binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000224)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)														---	---	---	---
RAD54L2	23132	broad.mit.edu	37	3	51696633	51696633	+	Missense_Mutation	SNP	G	A	A	rs146832677	byFrequency	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:51696633G>A	uc011bdt.1	+	22	3726	c.3601G>A	c.(3601-3603)GCC>ACC	p.A1201T	RAD54L2_uc003dbh.2_Missense_Mutation_p.A790T|RAD54L2_uc011bdu.1_Missense_Mutation_p.A895T|RAD54L2_uc003dbj.2_Missense_Mutation_p.A527T	NM_015106	NP_055921	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2	1201						nucleus	ATP binding|DNA binding|helicase activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)														---	---	---	---
GRM2	2912	broad.mit.edu	37	3	51751698	51751698	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:51751698G>A	uc010hlv.2	+	5	2649	c.2410G>A	c.(2410-2412)GTG>ATG	p.V804M	GRM2_uc003dbo.3_Missense_Mutation_p.V186M|GRM2_uc010hlu.2_RNA	NM_000839	NP_000830	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2 isoform a	804	Helical; Name=7; (Potential).				synaptic transmission	integral to plasma membrane				lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)													---	---	---	---
RRP9	9136	broad.mit.edu	37	3	51970485	51970485	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:51970485C>T	uc003dbw.1	-	7	643	c.604G>A	c.(604-606)GTC>ATC	p.V202I		NM_004704	NP_004695	O43818	U3IP2_HUMAN	RNA, U3 small nucleolar interacting protein 2	202	WD 2.				rRNA processing	nucleolus|small nuclear ribonucleoprotein complex|small nucleolar ribonucleoprotein complex	RNA binding			breast(2)|ovary(1)	3				BRCA - Breast invasive adenocarcinoma(193;8.04e-05)|Kidney(197;0.000553)|KIRC - Kidney renal clear cell carcinoma(197;0.000724)														---	---	---	---
PARP3	10039	broad.mit.edu	37	3	51980202	51980202	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:51980202C>T	uc003dby.2	+	9	1490	c.1119C>T	c.(1117-1119)CAC>CAT	p.H373H	PARP3_uc003dbz.2_Silent_p.H380H	NM_005485	NP_005476	Q9Y6F1	PARP3_HUMAN	poly (ADP-ribose) polymerase family, member 3	373	PARP catalytic.				DNA repair|protein ADP-ribosylation	centriole|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)														---	---	---	---
GPR62	118442	broad.mit.edu	37	3	51989789	51989789	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:51989789C>T	uc003dca.3	+	1	460	c.121C>T	c.(121-123)CGC>TGC	p.R41C		NM_080865	NP_543141	Q9BZJ7	GPR62_HUMAN	G protein-coupled receptor 62	41	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)														---	---	---	---
TLR9	54106	broad.mit.edu	37	3	52255388	52255388	+	Missense_Mutation	SNP	G	A	A	rs142806370		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52255388G>A	uc003dda.1	-	2	3578	c.2944C>T	c.(2944-2946)CGG>TGG	p.R982W	TLR9_uc003ddb.2_Missense_Mutation_p.R1079W	NM_017442	NP_059138	Q9NR96	TLR9_HUMAN	toll-like receptor 9 isoform A precursor	982	TIR.|Cytoplasmic (Potential).				defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			large_intestine(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)													---	---	---	---
PHF7	51533	broad.mit.edu	37	3	52453868	52453868	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52453868C>A	uc003ddy.2	+	5	1012	c.206C>A	c.(205-207)CCT>CAT	p.P69H	PHF7_uc003ddz.2_Missense_Mutation_p.P69H	NM_016483	NP_057567	Q9BWX1	PHF7_HUMAN	PHD finger protein 7 isoform 1	69						nucleus	zinc ion binding			breast(1)	1				BRCA - Breast invasive adenocarcinoma(193;1.71e-05)|Kidney(197;0.00178)|KIRC - Kidney renal clear cell carcinoma(197;0.00201)|OV - Ovarian serous cystadenocarcinoma(275;0.0275)														---	---	---	---
SEMA3G	56920	broad.mit.edu	37	3	52475717	52475717	+	Intron	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52475717G>A	uc003dea.1	-							NM_020163	NP_064548			semaphorin sem2 precursor						multicellular organismal development	extracellular region|membrane	receptor activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00173)|KIRC - Kidney renal clear cell carcinoma(197;0.00196)|OV - Ovarian serous cystadenocarcinoma(275;0.0333)														---	---	---	---
TNNC1	7134	broad.mit.edu	37	3	52485861	52485861	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52485861C>A	uc003deb.2	-	4	242	c.216G>T	c.(214-216)GTG>GTT	p.V72V		NM_003280	NP_003271	P63316	TNNC1_HUMAN	troponin C, slow	72	EF-hand 2.|1.				cardiac muscle contraction|muscle filament sliding|regulation of ATPase activity|regulation of muscle filament sliding speed|ventricular cardiac muscle tissue morphogenesis	cytosol|troponin complex	actin filament binding|calcium ion binding|calcium-dependent protein binding|protein homodimerization activity|troponin I binding|troponin T binding				0				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00175)|KIRC - Kidney renal clear cell carcinoma(197;0.00198)|OV - Ovarian serous cystadenocarcinoma(275;0.0525)	Bepridil(DB01244)|Dihydroxyaluminium(DB01375)|Levosimendan(DB00922)													---	---	---	---
GNL3	26354	broad.mit.edu	37	3	52723158	52723158	+	Silent	SNP	T	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52723158T>G	uc003dfd.2	+	6	650	c.477T>G	c.(475-477)CCT>CCG	p.P159P	GNL3_uc011beh.1_RNA|GNL3_uc003dfe.2_Silent_p.P147P|GNL3_uc003dff.2_Silent_p.P147P|SNORD19_uc003dfg.1_5'Flank|SNORD19B_uc010hml.1_5'Flank	NM_014366	NP_055181	Q9BVP2	GNL3_HUMAN	guanine nucleotide binding protein-like 3	159					regulation of cell proliferation	nucleolus	GTP binding|protein binding				0				BRCA - Breast invasive adenocarcinoma(193;6.75e-05)|Kidney(197;0.000611)|KIRC - Kidney renal clear cell carcinoma(197;0.000773)|OV - Ovarian serous cystadenocarcinoma(275;0.048)														---	---	---	---
GLT8D1	55830	broad.mit.edu	37	3	52730046	52730046	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52730046A>G	uc003dfi.3	-	7	682	c.543T>C	c.(541-543)CTT>CTC	p.L181L	GLT8D1_uc003dfj.2_Silent_p.L181L|GLT8D1_uc003dfk.2_Silent_p.L181L|GLT8D1_uc003dfl.2_Silent_p.L181L|GLT8D1_uc003dfm.2_Silent_p.L181L|GLT8D1_uc003dfn.2_Silent_p.L181L|GLT8D1_uc003dfo.1_Silent_p.L181L	NM_152932	NP_690909	Q68CQ7	GL8D1_HUMAN	glycosyltransferase 8 domain containing 1	181	Lumenal (Potential).					integral to membrane|mitochondrion	transferase activity, transferring glycosyl groups				0				BRCA - Breast invasive adenocarcinoma(193;6.78e-05)|Kidney(197;0.000618)|KIRC - Kidney renal clear cell carcinoma(197;0.000779)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)														---	---	---	---
NEK4	6787	broad.mit.edu	37	3	52786250	52786250	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52786250T>C	uc003dfq.3	-	7	1255	c.1066A>G	c.(1066-1068)ACC>GCC	p.T356A	NEK4_uc011bej.1_Missense_Mutation_p.T267A|NEK4_uc003dfr.2_Missense_Mutation_p.T356A	NM_003157	NP_003148	P51957	NEK4_HUMAN	NIMA-related kinase 4	356					cell division|mitosis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(1)	1				BRCA - Breast invasive adenocarcinoma(193;7.44e-05)|Kidney(197;0.000711)|KIRC - Kidney renal clear cell carcinoma(197;0.00086)|OV - Ovarian serous cystadenocarcinoma(275;0.0513)														---	---	---	---
CACNA1D	776	broad.mit.edu	37	3	53806910	53806910	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:53806910G>A	uc003dgv.3	+	33	4258	c.4095G>A	c.(4093-4095)GCG>GCA	p.A1365A	CACNA1D_uc003dgu.3_Silent_p.A1385A|CACNA1D_uc003dgy.3_Silent_p.A1350A|CACNA1D_uc003dgw.3_Silent_p.A1032A|CACNA1D_uc003dgx.1_Silent_p.A541A	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	1365	IV.|Helical; Name=S5 of repeat IV; (Potential).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)													---	---	---	---
WNT5A	7474	broad.mit.edu	37	3	55508419	55508419	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:55508419G>T	uc003dhn.2	-	4	948	c.630C>A	c.(628-630)TCC>TCA	p.S210S	WNT5A_uc003dhm.2_Silent_p.S195S|WNT5A_uc010hmw.2_Silent_p.S195S|WNT5A_uc010hmx.2_Silent_p.S121S	NM_003392	NP_003383	P41221	WNT5A_HUMAN	wingless-type MMTV integration site family,	210					activation of JUN kinase activity|activation of protein kinase B activity|axon guidance|cartilage development|cellular protein localization|cellular response to calcium ion|cellular response to interferon-gamma|cellular response to lipopolysaccharide|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|cervix development|cochlea morphogenesis|convergent extension involved in organogenesis|dopaminergic neuron differentiation|dorsal/ventral axis specification|embryonic digit morphogenesis|embryonic skeletal system development|epithelial cell proliferation involved in mammary gland duct elongation|epithelial to mesenchymal transition|face development|genitalia development|heart looping|hemopoietic stem cell proliferation|keratinocyte differentiation|lateral sprouting involved in mammary gland duct morphogenesis|lens development in camera-type eye|male gonad development|mammary gland branching involved in thelarche|negative regulation of apoptosis|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of mesenchymal cell proliferation|negative regulation of transcription, DNA-dependent|neural tube closure|olfactory bulb interneuron development|optic cup formation involved in camera-type eye development|palate development|positive regulation of angiogenesis|positive regulation of cartilage development|positive regulation of cGMP metabolic process|positive regulation of chemokine biosynthetic process|positive regulation of cytokine secretion involved in immune response|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of macrophage activation|positive regulation of macrophage cytokine production|positive regulation of mesenchymal cell proliferation|positive regulation of neuron projection development|positive regulation of NF-kappaB transcription factor activity|positive regulation of ossification|positive regulation of protein catabolic process|positive regulation of protein kinase C signaling cascade|positive regulation of T cell chemotaxis|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|primitive streak formation|regulation of branching involved in mammary gland duct morphogenesis|somitogenesis|tail morphogenesis|type B pancreatic cell development|urinary bladder development|uterus development|vagina development|Wnt receptor signaling pathway, calcium modulating pathway|wound healing	extracellular space|membrane fraction|plasma membrane|proteinaceous extracellular matrix	frizzled binding|frizzled-2 binding|receptor tyrosine kinase-like orphan receptor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0				KIRC - Kidney renal clear cell carcinoma(284;0.00377)|Kidney(284;0.00408)|OV - Ovarian serous cystadenocarcinoma(275;0.204)														---	---	---	---
FLNB	2317	broad.mit.edu	37	3	58127668	58127668	+	Intron	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:58127668G>T	uc003djj.2	+						FLNB_uc010hne.2_Intron|FLNB_uc003djk.2_Intron|FLNB_uc010hnf.2_Intron|FLNB_uc003djl.2_Intron|FLNB_uc003djm.2_Intron	NM_001457	NP_001448			filamin B isoform 2						actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)														---	---	---	---
KCTD6	200845	broad.mit.edu	37	3	58486884	58486884	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:58486884C>T	uc003dkj.3	+	3	356	c.239C>T	c.(238-240)CCG>CTG	p.P80L	KCTD6_uc003dki.3_Missense_Mutation_p.P80L|KCTD6_uc003dkk.3_Missense_Mutation_p.P80L	NM_001128214	NP_001121686	Q8NC69	KCTD6_HUMAN	potassium channel tetramerisation domain	80	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1				BRCA - Breast invasive adenocarcinoma(55;0.000177)|Kidney(10;0.00229)|KIRC - Kidney renal clear cell carcinoma(10;0.00258)|OV - Ovarian serous cystadenocarcinoma(275;0.148)														---	---	---	---
PRICKLE2	166336	broad.mit.edu	37	3	64184458	64184458	+	Splice_Site	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:64184458A>G	uc003dmf.2	-	2	730	c.144_splice	c.e2+1	p.Q48_splice		NM_198859	NP_942559			prickle-like 2							cytoplasm|nuclear membrane	zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)														---	---	---	---
MAGI1	9223	broad.mit.edu	37	3	66023754	66023754	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:66023754C>A	uc003dmn.2	-	1	756	c.230G>T	c.(229-231)CGG>CTG	p.R77L	MAGI1_uc003dmm.2_Missense_Mutation_p.R77L|MAGI1_uc003dmo.2_Missense_Mutation_p.R77L|MAGI1_uc003dmp.2_Missense_Mutation_p.R77L|MAGI1_uc003dmr.2_Missense_Mutation_p.R77L	NM_001033057	NP_001028229	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ	77	PDZ 1.				cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			lung(2)|skin(1)|breast(1)|kidney(1)|pancreas(1)	6		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)														---	---	---	---
LRIG1	26018	broad.mit.edu	37	3	66455662	66455662	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:66455662T>C	uc003dmx.2	-	9	1134	c.1120A>G	c.(1120-1122)ACG>GCG	p.T374A	LRIG1_uc011bfu.1_5'Flank|LRIG1_uc003dmw.2_Missense_Mutation_p.T40A|LRIG1_uc010hnz.2_Missense_Mutation_p.T114A|LRIG1_uc010hoa.2_Missense_Mutation_p.T374A	NM_015541	NP_056356	Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like	374	Extracellular (Potential).|LRR 13.					integral to membrane				skin(3)|ovary(2)	5		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)														---	---	---	---
MITF	4286	broad.mit.edu	37	3	70014292	70014292	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:70014292C>A	uc003dnz.2	+	10	1572	c.1456C>A	c.(1456-1458)CCC>ACC	p.P486T	MITF_uc011bgb.1_Missense_Mutation_p.P434T|MITF_uc003doa.2_Missense_Mutation_p.P485T|MITF_uc003dob.2_Missense_Mutation_p.P470T|MITF_uc003dod.2_Missense_Mutation_p.P461T|MITF_uc003doe.2_Missense_Mutation_p.P379T|MITF_uc003dof.2_Missense_Mutation_p.P385T	NM_198159	NP_937802	O75030	MITF_HUMAN	microphthalmia-associated transcription factor	492					melanocyte differentiation|multicellular organismal development|protein complex assembly	nucleus|protein complex	DNA binding|protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			ovary(2)	2		Lung NSC(201;0.0384)|Prostate(884;0.0526)		BRCA - Breast invasive adenocarcinoma(55;3.07e-05)|Epithelial(33;0.000138)|LUSC - Lung squamous cell carcinoma(21;0.008)|Lung(16;0.0107)|KIRC - Kidney renal clear cell carcinoma(39;0.204)|Kidney(39;0.239)				A		melanoma 		Waardenburg syndrome type 2|Tietz syndrome						---	---	---	---
GPR27	2850	broad.mit.edu	37	3	71803853	71803853	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:71803853G>A	uc011bge.1	+	1	653	c.653G>A	c.(652-654)CGC>CAC	p.R218H	EIF4E3_uc003dox.2_5'Flank|EIF4E3_uc011bgd.1_5'Flank|EIF4E3_uc010hoc.2_5'UTR	NM_018971	NP_061844	Q9NS67	GPR27_HUMAN	G protein-coupled receptor 27	218	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1		Prostate(10;0.00899)		BRCA - Breast invasive adenocarcinoma(55;1.78e-05)|Epithelial(33;5.75e-05)|Lung(16;0.0012)|LUSC - Lung squamous cell carcinoma(21;0.00156)														---	---	---	---
CNTN3	5067	broad.mit.edu	37	3	74350697	74350697	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:74350697C>T	uc003dpm.1	-	15	2027	c.1947G>A	c.(1945-1947)GTG>GTA	p.V649V		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	649	Fibronectin type-III 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)														---	---	---	---
OR5H1	26341	broad.mit.edu	37	3	97852151	97852151	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:97852151G>A	uc011bgt.1	+	1	610	c.610G>A	c.(610-612)GGT>AGT	p.G204S		NM_001005338	NP_001005338	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H,	204	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2																		---	---	---	---
GPR128	84873	broad.mit.edu	37	3	100413713	100413713	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:100413713G>A	uc003duc.2	+	16	2530	c.2262G>A	c.(2260-2262)AGG>AGA	p.R754R	GPR128_uc011bhc.1_Silent_p.R455R|GPR128_uc003dud.2_Silent_p.R277R	NM_032787	NP_116176	Q96K78	GP128_HUMAN	G protein-coupled receptor 128 precursor	754	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(1)	4																		---	---	---	---
SENP7	57337	broad.mit.edu	37	3	101136469	101136469	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:101136469T>C	uc003dut.2	-	5	561	c.450A>G	c.(448-450)GAA>GAG	p.E150E	SENP7_uc003duu.2_Silent_p.E150E|SENP7_uc003duv.2_Silent_p.E117E|SENP7_uc003duw.2_Intron|SENP7_uc003dux.2_Intron	NM_020654	NP_065705	Q9BQF6	SENP7_HUMAN	sentrin/SUMO-specific protease 7 isoform 1	150					proteolysis	nucleus	cysteine-type peptidase activity			ovary(3)|lung(2)	5																		---	---	---	---
CEP97	79598	broad.mit.edu	37	3	101481356	101481356	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:101481356T>C	uc003dvk.1	+	10	1872	c.1845T>C	c.(1843-1845)CGT>CGC	p.R615R	CEP97_uc011bhf.1_Silent_p.R556R|CEP97_uc003dvl.1_Silent_p.R311R|CEP97_uc003dvm.1_Silent_p.R453R	NM_024548	NP_078824	Q8IW35	CEP97_HUMAN	centrosomal protein 97kDa	615	CEP110 binding.					centrosome|nucleus	protein binding			ovary(2)	2																		---	---	---	---
ALCAM	214	broad.mit.edu	37	3	105252520	105252520	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:105252520A>G	uc003dvx.2	+	5	1073	c.533A>G	c.(532-534)CAT>CGT	p.H178R	ALCAM_uc003dvw.1_Missense_Mutation_p.H178R|ALCAM_uc003dvy.2_Missense_Mutation_p.H178R|ALCAM_uc011bhh.1_Missense_Mutation_p.H127R|ALCAM_uc010hpp.2_5'UTR	NM_001627	NP_001618	Q13740	CD166_HUMAN	activated leukocyte cell adhesion molecule	178	Extracellular (Potential).|Ig-like V-type 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(2)|breast(1)	3																		---	---	---	---
CBLB	868	broad.mit.edu	37	3	105470339	105470339	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:105470339A>G	uc003dwc.2	-	5	1012	c.690T>C	c.(688-690)GTT>GTC	p.V230V	CBLB_uc011bhi.1_Silent_p.V252V|CBLB_uc003dwd.1_Silent_p.V230V|CBLB_uc003dwe.1_Silent_p.V230V|CBLB_uc011bhj.1_RNA	NM_170662	NP_733762	Q13191	CBLB_HUMAN	Cas-Br-M (murine) ecotropic retroviral	230	Potential.|Cbl-PTB.|EF-hand-like.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			lung(4)|ovary(3)|breast(1)|skin(1)	9								Mis S		AML								---	---	---	---
HHLA2	11148	broad.mit.edu	37	3	108072520	108072520	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:108072520C>T	uc003dwy.3	+	4	478	c.311C>T	c.(310-312)GCG>GTG	p.A104V	HHLA2_uc011bhl.1_Intron|HHLA2_uc010hpu.2_Missense_Mutation_p.A104V|HHLA2_uc003dwz.2_Missense_Mutation_p.A104V	NM_007072	NP_009003	Q9UM44	HHLA2_HUMAN	HERV-H LTR-associating 2 precursor	104	Ig-like V-type 1.					integral to membrane				ovary(1)	1																		---	---	---	---
PVRL3	25945	broad.mit.edu	37	3	110852716	110852716	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:110852716G>A	uc003dxt.1	+	6	1304	c.1304G>A	c.(1303-1305)CGT>CAT	p.R435H	PVRL3_uc003dxu.1_Intron	NM_015480	NP_056295	Q9NQS3	PVRL3_HUMAN	poliovirus receptor-related 3 precursor	435	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane	cell adhesion molecule binding|protein homodimerization activity	p.R435C(1)		upper_aerodigestive_tract(2)	2																		---	---	---	---
BOC	91653	broad.mit.edu	37	3	112991451	112991451	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:112991451A>G	uc003dzx.2	+	7	1483	c.862A>G	c.(862-864)ACC>GCC	p.T288A	BOC_uc003dzy.2_Missense_Mutation_p.T288A|BOC_uc003dzz.2_Missense_Mutation_p.T288A|BOC_uc003eab.2_5'UTR	NM_033254	NP_150279	Q9BWV1	BOC_HUMAN	brother of CDO precursor	288	Ig-like C2-type 3.|Extracellular (Potential).				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|pancreas(1)	6			Epithelial(53;0.227)															---	---	---	---
CCDC52	152185	broad.mit.edu	37	3	113179491	113179491	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:113179491T>A	uc003eag.3	-	12	1699	c.1408A>T	c.(1408-1410)ACA>TCA	p.T470S	CCDC52_uc003eaf.3_RNA|CCDC52_uc003eah.1_Missense_Mutation_p.T366S	NM_144718	NP_653319	Q8N0Z3	SPICE_HUMAN	coiled-coil domain containing 52	470					cell division|mitosis	centriole|spindle	protein binding				0																		---	---	---	---
UPK1B	7348	broad.mit.edu	37	3	118909928	118909928	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:118909928A>G	uc003ecc.2	+	5	534	c.445A>G	c.(445-447)ACC>GCC	p.T149A	UPK1B_uc011bix.1_Missense_Mutation_p.T69A|UPK1B_uc003ecd.2_Missense_Mutation_p.T141A	NM_006952	NP_008883	O75841	UPK1B_HUMAN	uroplakin 1B	149	Extracellular (Potential).				epithelial cell differentiation	integral to membrane	structural molecule activity				0				GBM - Glioblastoma multiforme(114;0.222)														---	---	---	---
NR1I2	8856	broad.mit.edu	37	3	119531741	119531741	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:119531741T>C	uc003edj.2	+	5	2567	c.728T>C	c.(727-729)ATG>ACG	p.M243T	NR1I2_uc003edi.2_Missense_Mutation_p.M206T|NR1I2_uc003edk.2_Missense_Mutation_p.M282T|NR1I2_uc003edl.2_Missense_Mutation_p.M131T	NM_003889	NP_003880	O75469	NR1I2_HUMAN	nuclear receptor subfamily 1, group I, member 2	243	Ligand-binding.				drug export|exogenous drug catabolic process|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid metabolic process|xenobiotic metabolic process|xenobiotic transport	nucleoplasm	drug binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(114;0.175)	Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Rifampin(DB01045)|Vitamin E(DB00163)													---	---	---	---
POLQ	10721	broad.mit.edu	37	3	121206385	121206385	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:121206385G>T	uc003eee.3	-	16	5522	c.5393C>A	c.(5392-5394)CCT>CAT	p.P1798H	POLQ_uc003eed.2_Missense_Mutation_p.P970H	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	1798					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)									DNA_polymerases_(catalytic_subunits)					---	---	---	---
POLQ	10721	broad.mit.edu	37	3	121260235	121260235	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:121260235G>T	uc003eee.3	-	3	564	c.435C>A	c.(433-435)CCC>CCA	p.P145P		NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	145	Helicase ATP-binding.				DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)									DNA_polymerases_(catalytic_subunits)					---	---	---	---
KPNA1	3836	broad.mit.edu	37	3	122146494	122146494	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:122146494T>C	uc003efd.1	-	13	1356	c.1320A>G	c.(1318-1320)GTA>GTG	p.V440V	KPNA1_uc003efb.1_Silent_p.V239V|KPNA1_uc003efc.1_Silent_p.V239V|KPNA1_uc011bjr.1_Silent_p.V239V|KPNA1_uc010hrh.2_Silent_p.V239V|KPNA1_uc003efe.2_Silent_p.V440V	NM_002264	NP_002255	P52294	IMA1_HUMAN	karyopherin alpha 1	440	ARM 9.				DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|regulation of DNA recombination|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein binding|protein transporter activity				0				GBM - Glioblastoma multiforme(114;0.0898)														---	---	---	---
ITGB5	3693	broad.mit.edu	37	3	124492710	124492710	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:124492710G>A	uc003eho.2	-	11	2040	c.1743C>T	c.(1741-1743)ATC>ATT	p.I581I	ITGB5_uc010hrx.2_RNA|ITGB5_uc003ehp.1_RNA	NM_002213	NP_002204	P18084	ITB5_HUMAN	integrin, beta 5 precursor	581	III.|Extracellular (Potential).|Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|muscle contraction	integrin complex	receptor activity			skin(2)	2				GBM - Glioblastoma multiforme(114;0.163)														---	---	---	---
CCDC37	348807	broad.mit.edu	37	3	126137587	126137587	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:126137587A>G	uc003eiu.1	+	7	719	c.620A>G	c.(619-621)AAT>AGT	p.N207S	CCDC37_uc010hsg.1_Missense_Mutation_p.N208S	NM_182628	NP_872434	Q494V2	CCD37_HUMAN	coiled-coil domain containing 37	207										ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.166)														---	---	---	---
C3orf22	152065	broad.mit.edu	37	3	126268739	126268739	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:126268739G>A	uc003ejb.2	-	4	727	c.398C>T	c.(397-399)GCG>GTG	p.A133V		NM_152533	NP_689746	Q8N5N4	CC022_HUMAN	hypothetical protein LOC152065	133											0				GBM - Glioblastoma multiforme(114;0.147)														---	---	---	---
MCM2	4171	broad.mit.edu	37	3	127339714	127339714	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:127339714C>G	uc003ejp.2	+	14	2496	c.2439C>G	c.(2437-2439)AGC>AGG	p.S813R	MCM2_uc011bkm.1_Missense_Mutation_p.S683R|MCM2_uc010hsl.2_RNA|MCM2_uc011bkn.1_Missense_Mutation_p.S766R	NM_004526	NP_004517	P49736	MCM2_HUMAN	minichromosome maintenance complex component 2	813					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|helicase activity|metal ion binding			ovary(3)|skin(1)	4																		---	---	---	---
PIK3R4	30849	broad.mit.edu	37	3	130422668	130422668	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:130422668A>G	uc003enj.2	-	13	3578	c.2997T>C	c.(2995-2997)ATT>ATC	p.I999I		NM_014602	NP_055417	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	999	WD 1.				fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|breast(2)|skin(2)|stomach(1)|central_nervous_system(1)|kidney(1)	12																		---	---	---	---
PIK3R4	30849	broad.mit.edu	37	3	130463961	130463961	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:130463961A>G	uc003enj.2	-	2	683	c.102T>C	c.(100-102)AGT>AGC	p.S34S		NM_014602	NP_055417	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	34	ATP (By similarity).|Protein kinase.				fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|breast(2)|skin(2)|stomach(1)|central_nervous_system(1)|kidney(1)	12																		---	---	---	---
ATP2C1	27032	broad.mit.edu	37	3	130717188	130717188	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:130717188C>T	uc003enl.2	+	26	2664	c.2442C>T	c.(2440-2442)TGC>TGT	p.C814C	ATP2C1_uc011blg.1_Silent_p.C848C|ATP2C1_uc011blh.1_Silent_p.C809C|ATP2C1_uc011bli.1_Silent_p.C848C|ATP2C1_uc003enk.2_Silent_p.C798C|ATP2C1_uc003enm.2_Silent_p.C814C|ATP2C1_uc003enn.2_Silent_p.C798C|ATP2C1_uc003eno.2_Silent_p.C814C|ATP2C1_uc003enp.2_Silent_p.C814C|ATP2C1_uc003enq.2_Silent_p.C814C|ATP2C1_uc003enr.2_Silent_p.C814C|ATP2C1_uc003ens.2_Silent_p.C814C|ATP2C1_uc003ent.2_Silent_p.C814C|ATP2C1_uc003enu.2_Silent_p.C492C	NM_014382	NP_055197	P98194	AT2C1_HUMAN	calcium-transporting ATPase 2C1 isoform 1a	814	Helical; Name=8; (By similarity).				actin cytoskeleton reorganization|ATP biosynthetic process|calcium-dependent cell-cell adhesion|cellular calcium ion homeostasis|cellular manganese ion homeostasis|epidermis development|Golgi calcium ion homeostasis|Golgi calcium ion transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi apparatus|Golgi membrane|integral to membrane|trans-Golgi network	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|manganese ion binding|manganese-transporting ATPase activity|metal ion binding|signal transducer activity			skin(1)	1					Arsenic trioxide(DB01169)|Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Miconazole(DB01110)|Sevoflurane(DB01236)									Hailey-Hailey_disease				---	---	---	---
ACPP	55	broad.mit.edu	37	3	132071668	132071668	+	Splice_Site	SNP	G	A	A	rs144833647		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:132071668G>A	uc010htp.2	+	9	1058	c.968_splice	c.e9+1	p.G323_splice	ACPP_uc003eon.3_Splice_Site_p.G290_splice|ACPP_uc003eop.3_Splice_Site_p.G323_splice	NM_001099	NP_001090			acid phosphatase, prostate short isoform							extracellular region|lysosomal membrane	5'-nucleotidase activity|acid phosphatase activity			ovary(1)	1																		---	---	---	---
ZBTB38	253461	broad.mit.edu	37	3	141161284	141161284	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:141161284G>T	uc003etw.2	+	8	1036	c.54G>T	c.(52-54)ACG>ACT	p.T18T	ZBTB38_uc010hun.2_Silent_p.T15T|ZBTB38_uc010huo.2_Silent_p.T18T|ZBTB38_uc003ety.2_Silent_p.T18T|ZBTB38_uc010hup.2_Silent_p.T19T	NM_001080412	NP_001073881	Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	18					positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3																		---	---	---	---
GRK7	131890	broad.mit.edu	37	3	141497368	141497368	+	Missense_Mutation	SNP	G	A	A	rs34429284	byFrequency	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:141497368G>A	uc011bnd.1	+	1	326	c.242G>A	c.(241-243)CGC>CAC	p.R81H		NM_139209	NP_631948	Q8WTQ7	GRK7_HUMAN	G-protein-coupled receptor kinase 7 precursor	81	RGS.				visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			lung(2)|stomach(1)|ovary(1)|skin(1)	5																		---	---	---	---
CPA3	1359	broad.mit.edu	37	3	148597629	148597629	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:148597629G>A	uc003ewm.2	+	6	581	c.529G>A	c.(529-531)GCA>ACA	p.A177T		NM_001870	NP_001861	P15088	CBPA3_HUMAN	carboxypeptidase A3 precursor	177					proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			breast(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)															---	---	---	---
FAM194A	131831	broad.mit.edu	37	3	150421612	150421612	+	Nonsense_Mutation	SNP	A	T	T	rs144754399		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:150421612A>T	uc003eyg.2	-	1	131	c.74T>A	c.(73-75)TTA>TAA	p.L25*	FAM194A_uc003eyh.2_5'UTR	NM_152394	NP_689607	Q7L0X2	F194A_HUMAN	hypothetical protein LOC131831	25	Glu-rich.									skin(2)|ovary(1)	3																		---	---	---	---
FAM194A	131831	broad.mit.edu	37	3	150421613	150421613	+	Missense_Mutation	SNP	A	C	C	rs147867348		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:150421613A>C	uc003eyg.2	-	1	130	c.73T>G	c.(73-75)TTA>GTA	p.L25V	FAM194A_uc003eyh.2_5'UTR	NM_152394	NP_689607	Q7L0X2	F194A_HUMAN	hypothetical protein LOC131831	25	Glu-rich.									skin(2)|ovary(1)	3																		---	---	---	---
SIAH2	6478	broad.mit.edu	37	3	150460129	150460129	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:150460129G>A	uc003eyi.2	-	2	1401	c.774C>T	c.(772-774)GCC>GCT	p.A258A		NM_005067	NP_005058	O43255	SIAH2_HUMAN	seven in absentia homolog 2	258	SBD.				apoptosis|axon guidance|cell cycle|negative regulation of canonical Wnt receptor signaling pathway|small GTPase mediated signal transduction|ubiquitin-dependent protein catabolic process	cytosol|nucleus	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)															---	---	---	---
MED12L	116931	broad.mit.edu	37	3	151129094	151129094	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:151129094G>A	uc003eyp.2	+	39	5872	c.5834G>A	c.(5833-5835)GGG>GAG	p.G1945E	MED12L_uc011bnz.1_Intron	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	1945	Gln-rich.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)															---	---	---	---
MME	4311	broad.mit.edu	37	3	154861271	154861271	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:154861271C>T	uc010hvr.1	+	13	1439	c.1228C>T	c.(1228-1230)CGT>TGT	p.R410C	MME_uc003fab.1_Missense_Mutation_p.R410C|MME_uc003fac.1_Missense_Mutation_p.R410C|MME_uc003fad.1_Missense_Mutation_p.R410C|MME_uc003fae.1_Missense_Mutation_p.R410C	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	410	Extracellular (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)													---	---	---	---
SHOX2	6474	broad.mit.edu	37	3	157815808	157815808	+	3'UTR	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:157815808C>T	uc003fbr.2	-	5					SHOX2_uc003fbs.2_3'UTR|SHOX2_uc010hvw.2_3'UTR	NM_006884	NP_006875			short stature homeobox 2 isoform a						nervous system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			Lung(72;0.00318)|LUSC - Lung squamous cell carcinoma(72;0.0043)															---	---	---	---
SMC4	10051	broad.mit.edu	37	3	160150859	160150859	+	Silent	SNP	G	T	T	rs61762668	byFrequency	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:160150859G>T	uc003fdh.2	+	23	3689	c.3576G>T	c.(3574-3576)TCG>TCT	p.S1192S	IFT80_uc003fda.2_Intron|SMC4_uc003fdi.2_Silent_p.S1167S|SMC4_uc003fdj.2_Silent_p.S1192S|SMC4_uc010hwd.2_Silent_p.S1134S|SMC4_uc003fdl.2_Silent_p.S895S	NM_001002800	NP_001002800	Q9NTJ3	SMC4_HUMAN	SMC4 structural maintenance of chromosomes	1192	Ala/Asp-rich (DA-box).				cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			ovary(1)|breast(1)	2			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)															---	---	---	---
B3GALNT1	8706	broad.mit.edu	37	3	160804426	160804426	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:160804426G>T	uc003fdv.2	-	5	536	c.117C>A	c.(115-117)CCC>CCA	p.P39P	B3GALNT1_uc003fdw.2_Silent_p.P39P|B3GALNT1_uc003fdx.2_Silent_p.P39P|B3GALNT1_uc003fdy.2_Silent_p.P39P|B3GALNT1_uc003fdz.2_Silent_p.P39P|B3GALNT1_uc003fea.2_Silent_p.P39P|B3GALNT1_uc011bpa.1_Silent_p.P39P	NM_033169	NP_149359	O75752	B3GL1_HUMAN	UDP-Gal:betaGlcNAc beta	39	Helical; Signal-anchor for type II membrane protein; (Potential).				protein glycosylation	Golgi membrane|integral to membrane	galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			skin(1)	1			LUSC - Lung squamous cell carcinoma(72;4.41e-05)|Lung(72;4.61e-05)															---	---	---	---
ZBBX	79740	broad.mit.edu	37	3	167045770	167045770	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:167045770A>G	uc003fep.2	-	11	1145	c.822T>C	c.(820-822)CAT>CAC	p.H274H	ZBBX_uc011bpc.1_Silent_p.H274H|ZBBX_uc003feq.2_Silent_p.H245H	NM_024687	NP_078963	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	274						intracellular	zinc ion binding			ovary(2)	2																		---	---	---	---
PRKCI	5584	broad.mit.edu	37	3	170013723	170013723	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:170013723T>A	uc003fgs.2	+	15	1680	c.1442T>A	c.(1441-1443)ATA>AAA	p.I481K	PRKCI_uc003fgt.2_Missense_Mutation_p.I36K	NM_002740	NP_002731	P41743	KPCI_HUMAN	protein kinase C, iota	481	Protein kinase.				anti-apoptosis|cellular membrane organization|cellular response to insulin stimulus|establishment or maintenance of epithelial cell apical/basal polarity|intracellular signal transduction|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|protein targeting to membrane|secretion|tight junction assembly|vesicle-mediated transport	cytosol|endosome|nucleus|polarisome	ATP binding|phospholipid binding|protein binding|protein kinase C activity|zinc ion binding			lung(2)|ovary(1)|breast(1)|skin(1)	5	all_cancers(22;6.45e-23)|all_epithelial(15;8.52e-28)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)															---	---	---	---
FNDC3B	64778	broad.mit.edu	37	3	172061960	172061960	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:172061960A>G	uc003fhy.2	+	19	2334	c.2162A>G	c.(2161-2163)TAC>TGC	p.Y721C	FNDC3B_uc003fhz.3_Missense_Mutation_p.Y721C	NM_022763	NP_073600	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	721	Fibronectin type-III 5.					endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)														---	---	---	---
GHSR	2693	broad.mit.edu	37	3	172165646	172165646	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:172165646G>A	uc003fib.1	-	1	558	c.558C>T	c.(556-558)CAC>CAT	p.H186H	GHSR_uc011bpv.1_Silent_p.H186H	NM_198407	NP_940799	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor isoform 1a	186	Extracellular (Potential).				actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			lung(3)|ovary(1)|central_nervous_system(1)	5	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)															---	---	---	---
PIK3CA	5290	broad.mit.edu	37	3	178952085	178952085	+	Missense_Mutation	SNP	A	G	G	rs121913279		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:178952085A>G	uc003fjk.2	+	21	3297	c.3140A>G	c.(3139-3141)CAT>CGT	p.H1047R		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	1047	PI3K/PI4K.		H -> L (in cancer).|H -> R (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; requires binding to p85 regulatory subunit to induce cellular transformation but not interaction with RAS; may mimic the conformatitonal change triggered by the interaction with RAS; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells; increases lipid kinase activity; may alter the interaction of the PI3K/ PI4K kinase domain with the cell membrane).|H -> Y (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.H1047R(1269)|p.H1047L(152)|p.H1047Y(31)|p.H1047Q(3)|p.H1047T(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			H1047R(BT20_BREAST)|H1047R(NCIH1048_LUNG)|H1047R(MCAS_OVARY)|H1047R(HCC1954_BREAST)|H1047R(RKO_LARGE_INTESTINE)|H1047L(EFM19_BREAST)|H1047R(CAL33_UPPER_AERODIGESTIVE_TRACT)|H1047R(CAL29_URINARY_TRACT)|H1047R(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|H1047R(LS180_LARGE_INTESTINE)|H1047R(T47D_BREAST)|H1047R(HCT116_LARGE_INTESTINE)|H1047R(HSC2_UPPER_AERODIGESTIVE_TRACT)|H1047R(SKOV3_OVARY)|H1047R(MDAMB453_BREAST)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			---	---	---	---
GNB4	59345	broad.mit.edu	37	3	179123026	179123026	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:179123026C>T	uc003fjv.3	-	9	1148	c.868G>A	c.(868-870)GAT>AAT	p.D290N	GNB4_uc003fju.3_Intron	NM_021629	NP_067642	Q9HAV0	GBB4_HUMAN	guanine nucleotide-binding protein, beta-4	290	WD 6.				cellular response to glucagon stimulus|energy reserve metabolic process	plasma membrane	signal transducer activity			skin(2)	2	all_cancers(143;2.01e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.0169)|BRCA - Breast invasive adenocarcinoma(182;0.237)															---	---	---	---
ATP11B	23200	broad.mit.edu	37	3	182583408	182583408	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:182583408T>C	uc003flb.2	+	13	1622	c.1365T>C	c.(1363-1365)AGT>AGC	p.S455S	ATP11B_uc003flc.2_Silent_p.S39S	NM_014616	NP_055431	Q9Y2G3	AT11B_HUMAN	ATPase, class VI, type 11B	455	Cytoplasmic (Potential).				aminophospholipid transport|ATP biosynthetic process	integral to membrane|nuclear inner membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;1.2e-42)|Epithelial(37;2.77e-36)|LUSC - Lung squamous cell carcinoma(7;7.58e-24)|Lung(8;4.66e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.35e-20)															---	---	---	---
EIF4G1	1981	broad.mit.edu	37	3	184035509	184035509	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:184035509G>A	uc003fnp.2	+	6	527	c.329G>A	c.(328-330)CGT>CAT	p.R110H	EIF4G1_uc003fno.1_Missense_Mutation_p.R51H|EIF4G1_uc010hxw.1_Intron|EIF4G1_uc003fnt.2_5'UTR|EIF4G1_uc003fnq.2_Missense_Mutation_p.R23H|EIF4G1_uc003fnr.2_5'UTR|EIF4G1_uc010hxx.2_Missense_Mutation_p.R117H|EIF4G1_uc003fns.2_Missense_Mutation_p.R70H|EIF4G1_uc010hxy.2_Missense_Mutation_p.R117H|EIF4G1_uc010hxz.1_Missense_Mutation_p.R23H|EIF4G1_uc003fnv.3_Missense_Mutation_p.R110H|EIF4G1_uc003fnu.3_Missense_Mutation_p.R110H|EIF4G1_uc003fnw.2_Missense_Mutation_p.R117H|EIF4G1_uc003fnx.2_5'Flank|EIF4G1_uc003fny.3_5'Flank	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	110					insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)															---	---	---	---
EIF4G1	1981	broad.mit.edu	37	3	184042123	184042123	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:184042123T>C	uc003fnp.2	+	17	2805	c.2607T>C	c.(2605-2607)GAT>GAC	p.D869D	EIF4G1_uc003fno.1_Silent_p.D810D|EIF4G1_uc010hxw.1_Silent_p.D705D|EIF4G1_uc003fnt.2_Silent_p.D580D|EIF4G1_uc003fnq.2_Silent_p.D782D|EIF4G1_uc003fnr.2_Silent_p.D705D|EIF4G1_uc010hxx.2_Silent_p.D876D|EIF4G1_uc003fns.2_Silent_p.D829D|EIF4G1_uc010hxy.2_Silent_p.D876D|EIF4G1_uc003fnv.3_Silent_p.D870D|EIF4G1_uc003fnu.3_Silent_p.D869D|EIF4G1_uc003fnw.2_Silent_p.D876D|EIF4G1_uc003fnx.2_Silent_p.D674D|EIF4G1_uc003fny.3_Silent_p.D673D|SNORD66_uc003fnz.2_5'Flank	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	869	eIF3/EIF4A-binding.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)															---	---	---	---
CLCN2	1181	broad.mit.edu	37	3	184071569	184071569	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:184071569C>T	uc003foi.2	-	16	1860	c.1736G>A	c.(1735-1737)CGT>CAT	p.R579H	CLCN2_uc003foh.2_Missense_Mutation_p.R103H|CLCN2_uc010hya.1_Missense_Mutation_p.R562H|CLCN2_uc011brl.1_Missense_Mutation_p.R579H|CLCN2_uc011brm.1_Missense_Mutation_p.R535H	NM_004366	NP_004357	P51788	CLCN2_HUMAN	chloride channel 2	579	Cytoplasmic (By similarity).					chloride channel complex	voltage-gated chloride channel activity				0	all_cancers(143;6.66e-11)|Ovarian(172;0.0339)		Epithelial(37;2.22e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Lubiprostone(DB01046)													---	---	---	---
OPA1	4976	broad.mit.edu	37	3	193334982	193334982	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:193334982C>T	uc003ftm.2	+	4	698	c.464C>T	c.(463-465)GCC>GTC	p.A155V	OPA1_uc003ftg.2_Missense_Mutation_p.A155V|OPA1_uc003fth.2_Intron|OPA1_uc003fti.2_Missense_Mutation_p.A155V|OPA1_uc003ftj.2_Missense_Mutation_p.A155V|OPA1_uc003ftk.2_Intron|OPA1_uc003ftl.2_Intron|OPA1_uc003ftn.2_Intron	NM_015560	NP_056375	O60313	OPA1_HUMAN	optic atrophy 1 isoform 1	155	Mitochondrial intermembrane (By similarity).				apoptosis|axon transport of mitochondrion|inner mitochondrial membrane organization|mitochondrial fission|mitochondrial fusion|positive regulation of anti-apoptosis|response to stimulus|visual perception	dendrite|integral to membrane|mitochondrial crista|mitochondrial intermembrane space|mitochondrial outer membrane	GTP binding|GTPase activity|magnesium ion binding|protein binding				0	all_cancers(143;9.56e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;9.19e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000162)														---	---	---	---
CPN2	1370	broad.mit.edu	37	3	194062086	194062086	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:194062086C>T	uc003fts.2	-	2	1436	c.1346G>A	c.(1345-1347)CGG>CAG	p.R449Q		NM_001080513	NP_001073982	P22792	CPN2_HUMAN	carboxypeptidase N, polypeptide 2	449					protein stabilization	extracellular region	enzyme regulator activity			ovary(5)	5	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.65e-05)														---	---	---	---
ATP13A3	79572	broad.mit.edu	37	3	194169309	194169309	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:194169309C>A	uc003fty.3	-	11	1429	c.1027G>T	c.(1027-1029)GGA>TGA	p.G343*	ATP13A3_uc003ftz.1_Nonsense_Mutation_p.G49*	NM_024524	NP_078800	Q9H7F0	AT133_HUMAN	ATPase type 13A3	343					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(1)	1	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)														---	---	---	---
RNF168	165918	broad.mit.edu	37	3	196199224	196199224	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:196199224G>T	uc003fwq.2	-	6	1720	c.1182C>A	c.(1180-1182)TCC>TCA	p.S394S	RNF168_uc010iah.2_Silent_p.S227S|uc010iag.1_5'Flank	NM_152617	NP_689830	Q8IYW5	RN168_HUMAN	ring finger protein 168	394					double-strand break repair|histone H2A K63-linked ubiquitination|positive regulation of DNA repair|response to ionizing radiation	nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;5.25e-24)|all cancers(36;5.47e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00348)														---	---	---	---
MFI2	4241	broad.mit.edu	37	3	196748318	196748318	+	Silent	SNP	G	A	A	rs148913417	byFrequency;by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:196748318G>A	uc003fxk.3	-	6	782	c.669C>T	c.(667-669)GAC>GAT	p.D223D	MFI2_uc003fxl.3_Silent_p.D223D|MFI2_uc011bua.1_Missense_Mutation_p.T196M	NM_005929	NP_005920	P08582	TRFM_HUMAN	melanoma-associated antigen p97 isoform 1	223	Transferrin-like 1.				cellular iron ion homeostasis|iron ion transport	anchored to membrane|extracellular region|integral to plasma membrane	ferric iron binding|protein binding				0	all_cancers(143;3.95e-09)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.55e-24)|all cancers(36;2.87e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00536)														---	---	---	---
ZNF718	255403	broad.mit.edu	37	4	155138	155138	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:155138T>C	uc003fzt.3	+	8	796	c.663T>C	c.(661-663)CAT>CAC	p.H221H	ZNF595_uc003fzu.1_Intron|ZNF718_uc010iaz.2_RNA|ZNF718_uc003fzw.3_Missense_Mutation_p.M1T	NM_001039127	NP_001034216	Q3SXZ3	ZN718_HUMAN	zinc finger protein 718	221	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0681)|Epithelial(2;0.0838)|all cancers(2;0.135)|LUSC - Lung squamous cell carcinoma(95;0.18)														---	---	---	---
TMEM175	84286	broad.mit.edu	37	4	951976	951976	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:951976G>A	uc003gbq.2	+	11	1305	c.1207G>A	c.(1207-1209)GAG>AAG	p.E403K	TMEM175_uc003gbr.2_Missense_Mutation_p.E321K|TMEM175_uc003gbu.2_Missense_Mutation_p.E321K|TMEM175_uc003gbs.2_Missense_Mutation_p.E286K|TMEM175_uc003gbt.2_Missense_Mutation_p.E286K|TMEM175_uc003gbv.2_Missense_Mutation_p.E286K|TMEM175_uc010ibm.2_Missense_Mutation_p.E219K	NM_032326	NP_115702	Q9BSA9	TM175_HUMAN	transmembrane protein 175	403						integral to membrane					0			OV - Ovarian serous cystadenocarcinoma(23;0.0158)															---	---	---	---
TMEM175	84286	broad.mit.edu	37	4	952157	952157	+	Missense_Mutation	SNP	G	A	A	rs139453980		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:952157G>A	uc003gbq.2	+	11	1486	c.1388G>A	c.(1387-1389)CGC>CAC	p.R463H	TMEM175_uc003gbr.2_Missense_Mutation_p.R381H|TMEM175_uc003gbu.2_Missense_Mutation_p.R381H|TMEM175_uc003gbs.2_Missense_Mutation_p.R346H|TMEM175_uc003gbt.2_Missense_Mutation_p.R346H|TMEM175_uc003gbv.2_Missense_Mutation_p.R346H|TMEM175_uc010ibm.2_Missense_Mutation_p.R279H	NM_032326	NP_115702	Q9BSA9	TM175_HUMAN	transmembrane protein 175	463	Helical; (Potential).					integral to membrane					0			OV - Ovarian serous cystadenocarcinoma(23;0.0158)															---	---	---	---
IDUA	3425	broad.mit.edu	37	4	995261	995261	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:995261T>C	uc003gby.2	+	5	587	c.499T>C	c.(499-501)TAC>CAC	p.Y167H	IDUA_uc003gbz.2_RNA|IDUA_uc003gca.2_Missense_Mutation_p.Y120H	NM_000203	NP_000194	P35475	IDUA_HUMAN	alpha-L-iduronidase precursor	167					disaccharide metabolic process	lysosome	cation binding|L-iduronidase activity				0			OV - Ovarian serous cystadenocarcinoma(23;0.0158)		Laronidase(DB00090)													---	---	---	---
SPON2	10417	broad.mit.edu	37	4	1165270	1165270	+	Silent	SNP	G	A	A	rs141880428		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:1165270G>A	uc003gcn.3	-	2	252	c.225C>T	c.(223-225)GCC>GCT	p.A75A	SPON2_uc003gco.3_Silent_p.A75A|SPON2_uc010ibr.2_Silent_p.A75A|SPON2_uc003gcm.1_5'UTR	NM_012445	NP_036577	Q9BUD6	SPON2_HUMAN	spondin 2, extracellular matrix protein	75	Spondin.				axon guidance|cell adhesion|innate immune response	proteinaceous extracellular matrix	metal ion binding			central_nervous_system(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.00805)	UCEC - Uterine corpus endometrioid carcinoma (64;0.139)|Colorectal(103;0.19)														---	---	---	---
CRIPAK	285464	broad.mit.edu	37	4	1388791	1388791	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:1388791G>A	uc003gdf.2	+	1	3452	c.492G>A	c.(490-492)GTG>GTA	p.V164V		NM_175918	NP_787114	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	164					ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0106)															---	---	---	---
CRIPAK	285464	broad.mit.edu	37	4	1388836	1388836	+	Silent	SNP	C	T	T	rs148951627	byFrequency	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:1388836C>T	uc003gdf.2	+	1	3497	c.537C>T	c.(535-537)TGC>TGT	p.C179C		NM_175918	NP_787114	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	179	4.				ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0106)															---	---	---	---
WHSC2	7469	broad.mit.edu	37	4	1993312	1993312	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:1993312T>G	uc003gem.2	-	2	614	c.374A>C	c.(373-375)AAT>ACT	p.N125T	WHSC2_uc003gel.2_Missense_Mutation_p.N39T|WHSC2_uc003gen.2_Intron	NM_005663	NP_005654	Q9H3P2	NELFA_HUMAN	Wolf-Hirschhorn syndrome candidate 2 protein	114					multicellular organismal development|positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm				skin(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0155)															---	---	---	---
POLN	353497	broad.mit.edu	37	4	2083454	2083454	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:2083454G>A	uc003ger.2	-	20	2214	c.2214C>T	c.(2212-2214)ATC>ATT	p.I738I	POLN_uc010icg.1_Silent_p.I186I|POLN_uc010ich.1_Silent_p.I270I	NM_181808	NP_861524	Q7Z5Q5	DPOLN_HUMAN	DNA-directed DNA polymerase nu	738					DNA repair|DNA replication	nucleus	DNA binding|DNA-directed DNA polymerase activity			kidney(2)|ovary(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(23;0.0955)										DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					---	---	---	---
POLN	353497	broad.mit.edu	37	4	2209885	2209885	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:2209885G>T	uc003ger.2	-	3	543	c.543C>A	c.(541-543)GCC>GCA	p.A181A	POLN_uc010ich.1_5'UTR|POLN_uc011bvi.1_Silent_p.A181A	NM_181808	NP_861524	Q7Z5Q5	DPOLN_HUMAN	DNA-directed DNA polymerase nu	181					DNA repair|DNA replication	nucleus	DNA binding|DNA-directed DNA polymerase activity			kidney(2)|ovary(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(23;0.0955)										DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					---	---	---	---
FAM193A	8603	broad.mit.edu	37	4	2661631	2661631	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:2661631C>A	uc010icl.2	+	8	1073	c.722C>A	c.(721-723)CCA>CAA	p.P241Q	FAM193A_uc010ick.2_Missense_Mutation_p.P441Q|FAM193A_uc003gfd.2_Missense_Mutation_p.P241Q|FAM193A_uc011bvm.1_Missense_Mutation_p.P265Q|FAM193A_uc011bvn.1_Missense_Mutation_p.P241Q|FAM193A_uc011bvo.1_RNA|FAM193A_uc010icm.2_RNA|FAM193A_uc003gfe.2_Missense_Mutation_p.P95Q	NM_003704	NP_003695	P78312	F193A_HUMAN	hypothetical protein LOC8603	241										ovary(3)	3																		---	---	---	---
SH3BP2	6452	broad.mit.edu	37	4	2831297	2831297	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:2831297C>A	uc003gfi.3	+	8	784	c.664C>A	c.(664-666)CGG>AGG	p.R222R	SH3BP2_uc011bvp.1_Silent_p.R250R|SH3BP2_uc003gfj.3_Silent_p.R279R|SH3BP2_uc003gfk.3_Silent_p.R222R|SH3BP2_uc003gfl.3_Silent_p.R155R|SH3BP2_uc003gfm.3_Silent_p.R197R	NM_001122681	NP_001116153	P78314	3BP2_HUMAN	SH3-domain binding protein 2 isoform a	222					signal transduction		SH3 domain binding|SH3/SH2 adaptor activity			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.164)										Cherubism				---	---	---	---
RGS12	6002	broad.mit.edu	37	4	3318198	3318198	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:3318198C>T	uc003ggw.2	+	2	1205	c.301C>T	c.(301-303)CGC>TGC	p.R101C	RGS12_uc003ggu.2_Missense_Mutation_p.R101C|RGS12_uc010ics.1_Intron|RGS12_uc011bvr.1_RNA|RGS12_uc003ggv.2_Missense_Mutation_p.R101C|RGS12_uc003ggx.1_Missense_Mutation_p.R101C	NM_198229	NP_937872	O14924	RGS12_HUMAN	regulator of G-protein signalling 12 isoform 1	101						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)														---	---	---	---
RGS12	6002	broad.mit.edu	37	4	3425305	3425305	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:3425305G>A	uc003ggw.2	+	13	4075	c.3171G>A	c.(3169-3171)ACG>ACA	p.T1057T	RGS12_uc003ggv.2_Silent_p.T1057T|RGS12_uc003ggy.1_Silent_p.T455T|RGS12_uc003ggz.2_Silent_p.T409T|RGS12_uc010icu.1_Silent_p.T256T|RGS12_uc011bvs.1_Silent_p.T399T|RGS12_uc003gha.2_Silent_p.T399T|RGS12_uc010icv.2_Silent_p.T256T|RGS12_uc003ghb.2_Silent_p.T256T	NM_198229	NP_937872	O14924	RGS12_HUMAN	regulator of G-protein signalling 12 isoform 1	1057	RBD 2.					condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)														---	---	---	---
HGFAC	3083	broad.mit.edu	37	4	3444812	3444812	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:3444812T>C	uc003ghc.2	+	3	337	c.334T>C	c.(334-336)TTC>CTC	p.F112L	HGFAC_uc010icw.2_Missense_Mutation_p.F112L	NM_001528	NP_001519	Q04756	HGFA_HUMAN	HGF activator preproprotein	112	Fibronectin type-II.				proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(2)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)														---	---	---	---
DOK7	285489	broad.mit.edu	37	4	3494914	3494914	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:3494914C>A	uc003ghd.2	+	7	1271	c.1201C>A	c.(1201-1203)CTG>ATG	p.L401M	DOK7_uc003ghe.2_Missense_Mutation_p.L263M|DOK7_uc003ghf.2_Silent_p.P142P|DOK7_uc003ghg.1_Missense_Mutation_p.L91M	NM_173660	NP_775931	Q18PE1	DOK7_HUMAN	downstream of tyrosine kinase 7 isoform 1	401					positive regulation of protein tyrosine kinase activity	cell junction|synapse	insulin receptor binding|protein kinase binding			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)														---	---	---	---
TMEM128	85013	broad.mit.edu	37	4	4239591	4239591	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:4239591A>G	uc003ghr.1	-	4	500	c.470T>C	c.(469-471)GTT>GCT	p.V157A	TMEM128_uc003ghq.1_Missense_Mutation_p.V133A|TMEM128_uc003ghs.2_3'UTR|TMEM128_uc011bvv.1_Missense_Mutation_p.V157A|TMEM128_uc011bvw.1_Intron	NM_032927	NP_116316	Q5BJH2	TM128_HUMAN	transmembrane protein 128	157	Helical; (Potential).					integral to membrane					0				UCEC - Uterine corpus endometrioid carcinoma (64;0.166)														---	---	---	---
CYTL1	54360	broad.mit.edu	37	4	5021035	5021035	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:5021035C>A	uc003gig.2	-	1	163	c.138G>T	c.(136-138)CAG>CAT	p.Q46H		NM_018659	NP_061129	Q9NRR1	CYTL1_HUMAN	cytokine-like 1 precursor	46					signal transduction	extracellular space|soluble fraction	receptor binding			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.164)														---	---	---	---
MAN2B2	23324	broad.mit.edu	37	4	6621751	6621751	+	Missense_Mutation	SNP	C	T	T	rs149521690	byFrequency;by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:6621751C>T	uc003gjf.1	+	18	2948	c.2912C>T	c.(2911-2913)ACG>ATG	p.T971M	MAN2B2_uc003gje.1_3'UTR|MAN2B2_uc011bwf.1_Missense_Mutation_p.T920M	NM_015274	NP_056089	Q9Y2E5	MA2B2_HUMAN	mannosidase, alpha, class 2B, member 2	971					mannose metabolic process	extracellular region	alpha-mannosidase activity|carbohydrate binding|zinc ion binding			ovary(2)	2																		---	---	---	---
ABLIM2	84448	broad.mit.edu	37	4	7985021	7985021	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:7985021C>T	uc003gko.2	-	19	1835	c.1692G>A	c.(1690-1692)CTG>CTA	p.L564L	ABLIM2_uc003gkk.2_Silent_p.L189L|ABLIM2_uc003gkl.2_Silent_p.L292L|ABLIM2_uc003gkj.3_Silent_p.L598L|ABLIM2_uc003gkm.3_Silent_p.L512L|ABLIM2_uc003gkp.2_Silent_p.L484L|ABLIM2_uc003gkq.2_Silent_p.L525L|ABLIM2_uc003gkr.2_Silent_p.L474L|ABLIM2_uc003gki.2_RNA	NM_001130084	NP_001123556	Q6H8Q1	ABLM2_HUMAN	actin binding LIM protein family, member 2	564	HP.				axon guidance|cytoskeleton organization	actin cytoskeleton|cytoplasm|intermediate filament cytoskeleton|nucleus	actin binding|zinc ion binding			pancreas(3)	3																		---	---	---	---
DRD5	1816	broad.mit.edu	37	4	9783796	9783796	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:9783796C>T	uc003gmb.3	+	1	539	c.143C>T	c.(142-144)ACC>ATC	p.T48I		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	48	Helical; Name=1; (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)													---	---	---	---
BOD1L	259282	broad.mit.edu	37	4	13605418	13605418	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:13605418C>T	uc003gmz.1	-	10	3223	c.3106G>A	c.(3106-3108)GAC>AAC	p.D1036N	BOD1L_uc010idr.1_Missense_Mutation_p.D373N	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	1036	Lys-rich.						DNA binding			ovary(5)|breast(1)	6																		---	---	---	---
CPEB2	132864	broad.mit.edu	37	4	15055827	15055827	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:15055827A>G	uc003gni.1	+	7	1199	c.1112A>G	c.(1111-1113)TAT>TGT	p.Y371C	CPEB2_uc003gnj.1_Missense_Mutation_p.Y341C|CPEB2_uc003gnk.1_Missense_Mutation_p.Y379C|CPEB2_uc003gnl.1_Missense_Mutation_p.Y352C|CPEB2_uc003gnm.1_Missense_Mutation_p.Y349C|CPEB2_uc003gnn.1_Missense_Mutation_p.Y344C	NM_182485	NP_872291	Q7Z5Q1	CPEB2_HUMAN	cytoplasmic polyadenylation element binding	371	RRM 1.				regulation of translation	cytoplasm	nucleotide binding|RNA binding			skin(1)	1																		---	---	---	---
CD38	952	broad.mit.edu	37	4	15780217	15780217	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:15780217C>A	uc011bxc.1	+	1	287	c.180C>A	c.(178-180)CCC>CCA	p.P60P	CD38_uc003goj.1_Silent_p.P60P|CD38_uc003gol.1_Silent_p.P60P	NM_001775	NP_001766	P28907	CD38_HUMAN	CD38 antigen	60	Extracellular (Potential).				B cell receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of apoptosis|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of transcription, DNA-dependent|response to drug	integral to membrane|plasma membrane	binding|NAD+ nucleosidase activity|receptor activity			ovary(2)	2																		---	---	---	---
TAPT1	202018	broad.mit.edu	37	4	16165090	16165090	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:16165090T>C	uc010ied.1	-	14	1626	c.1545A>G	c.(1543-1545)ATA>ATG	p.I515M	TAPT1_uc011bxd.1_RNA|TAPT1_uc011bxe.1_Missense_Mutation_p.I404M	NM_153365	NP_699196	Q6NXT6	TAPT1_HUMAN	transmembrane anterior posterior transformation	515						integral to membrane	growth hormone-releasing hormone receptor activity				0																		---	---	---	---
SLIT2	9353	broad.mit.edu	37	4	20490474	20490474	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:20490474G>A	uc003gpr.1	+	8	848	c.644G>A	c.(643-645)TGC>TAC	p.C215Y	SLIT2_uc003gps.1_Missense_Mutation_p.C215Y	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	215	LRRCT 1.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11																		---	---	---	---
GPR125	166647	broad.mit.edu	37	4	22463424	22463424	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:22463424G>T	uc003gqm.1	-	3	602	c.337C>A	c.(337-339)CGA>AGA	p.R113R	GPR125_uc003gqo.2_Silent_p.R113R	NM_145290	NP_660333	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125 precursor	113	Extracellular (Potential).|LRR 2.				neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			skin(1)	1		Breast(46;0.198)																---	---	---	---
PI4K2B	55300	broad.mit.edu	37	4	25270149	25270149	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:25270149A>G	uc003grk.2	+	8	1296	c.1163A>G	c.(1162-1164)GAC>GGC	p.D388G	PI4K2B_uc011bxs.1_Missense_Mutation_p.D292G	NM_018323	NP_060793	Q8TCG2	P4K2B_HUMAN	phosphatidylinositol 4-kinase type 2 beta	388	PI3K/PI4K.					cytoplasm|membrane	1-phosphatidylinositol 4-kinase activity|ATP binding			ovary(2)|skin(2)	4		Breast(46;0.173)																---	---	---	---
STIM2	57620	broad.mit.edu	37	4	27024487	27024487	+	Missense_Mutation	SNP	G	A	A	rs145387199		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:27024487G>A	uc003gsh.3	+	13	2611	c.2395G>A	c.(2395-2397)GAC>AAC	p.D799N	STIM2_uc003gsg.3_Missense_Mutation_p.D791N|STIM2_uc010iex.2_3'UTR|STIM2_uc010iey.2_3'UTR	NM_020860	NP_065911	Q9P246	STIM2_HUMAN	stromal interaction molecule 2	704	Cytoplasmic (Potential).				activation of store-operated calcium channel activity|calcium ion transport|cellular calcium ion homeostasis|negative regulation of calcium ion transport via store-operated calcium channel activity	endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel regulator activity|calcium ion binding|protein binding			central_nervous_system(1)|skin(1)	2		Breast(46;0.0503)																---	---	---	---
FAM114A1	92689	broad.mit.edu	37	4	38910203	38910203	+	Intron	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:38910203T>C	uc003gtn.2	+						FAM114A1_uc011byh.1_Intron	NM_138389	NP_612398			hypothetical protein LOC92689							cytoplasm				ovary(1)	1																		---	---	---	---
N4BP2	55728	broad.mit.edu	37	4	40108561	40108561	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:40108561C>T	uc003guy.3	+	5	1753	c.1415C>T	c.(1414-1416)ACT>ATT	p.T472I	N4BP2_uc010ifq.2_Missense_Mutation_p.T392I|N4BP2_uc010ifr.2_Missense_Mutation_p.T392I	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	472						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8																		---	---	---	---
APBB2	323	broad.mit.edu	37	4	40818121	40818121	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:40818121G>T	uc003gvl.2	-	18	2895	c.2265C>A	c.(2263-2265)ACC>ACA	p.T755T	APBB2_uc010ifu.2_Silent_p.T327T|APBB2_uc003gvm.2_Silent_p.T733T|APBB2_uc003gvn.2_Silent_p.T756T|APBB2_uc003gvk.2_Silent_p.T207T	NM_173075	NP_775098	Q92870	APBB2_HUMAN	amyloid beta A4 precursor protein-binding,	755					cell cycle arrest|intracellular signal transduction|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|regulation of transcription, DNA-dependent	growth cone|lamellipodium|membrane|nucleus|synapse	beta-amyloid binding|transcription factor binding			ovary(2)|large_intestine(1)	3																		---	---	---	---
LIMCH1	22998	broad.mit.edu	37	4	41607973	41607973	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:41607973G>A	uc003gvu.3	+	6	492	c.438G>A	c.(436-438)ACG>ACA	p.T146T	LIMCH1_uc003gvt.1_5'UTR|LIMCH1_uc003gvv.3_Silent_p.T146T|LIMCH1_uc003gvw.3_Silent_p.T146T|LIMCH1_uc003gvx.3_Silent_p.T146T|LIMCH1_uc003gwe.3_Silent_p.T146T|LIMCH1_uc003gvy.3_5'UTR|LIMCH1_uc003gwa.3_5'UTR|LIMCH1_uc003gvz.3_5'UTR	NM_014988	NP_055803	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1 isoform a	146					actomyosin structure organization		actin binding|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4																		---	---	---	---
GUF1	60558	broad.mit.edu	37	4	44699434	44699434	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:44699434C>T	uc003gww.3	+	16	2052	c.1845C>T	c.(1843-1845)GCC>GCT	p.A615A	GUF1_uc011bza.1_Silent_p.A22A	NM_021927	NP_068746	Q8N442	GUF1_HUMAN	GUF1 GTPase homolog	615					translation	mitochondrial inner membrane	GTP binding|GTPase activity			upper_aerodigestive_tract(1)	1																		---	---	---	---
SLAIN2	57606	broad.mit.edu	37	4	48384616	48384616	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:48384616T>C	uc003gya.3	+	5	1038	c.894T>C	c.(892-894)TCT>TCC	p.S298S	SLAIN2_uc003gyb.1_5'UTR	NM_020846	NP_065897	Q9P270	SLAI2_HUMAN	SLAIN motif family, member 2	298						centrosome					0																		---	---	---	---
FRYL	285527	broad.mit.edu	37	4	48588687	48588687	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:48588687A>G	uc003gyh.1	-	19	2304	c.1699T>C	c.(1699-1701)TTG>CTG	p.L567L	FRYL_uc003gyk.2_Silent_p.L567L	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	567					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1																		---	---	---	---
FRYL	285527	broad.mit.edu	37	4	48622719	48622719	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:48622719C>T	uc003gyh.1	-	6	856	c.251G>A	c.(250-252)CGC>CAC	p.R84H	FRYL_uc003gyk.2_Missense_Mutation_p.R84H|FRYL_uc003gyl.1_Missense_Mutation_p.R135H|FRYL_uc003gym.1_Missense_Mutation_p.R84H	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	84					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1																		---	---	---	---
LRRC66	339977	broad.mit.edu	37	4	52883364	52883364	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:52883364T>C	uc003gzi.2	-	1	429	c.416A>G	c.(415-417)CAC>CGC	p.H139R		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	139						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3																		---	---	---	---
SPATA18	132671	broad.mit.edu	37	4	52943136	52943136	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:52943136C>T	uc003gzl.2	+	7	1228	c.950C>T	c.(949-951)GCG>GTG	p.A317V	SPATA18_uc010igl.1_RNA|SPATA18_uc011bzq.1_Missense_Mutation_p.A285V|SPATA18_uc003gzk.1_Missense_Mutation_p.A317V	NM_145263	NP_660306	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18 homolog	317					mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			ovary(2)|skin(2)	4			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)															---	---	---	---
FIP1L1	81608	broad.mit.edu	37	4	54325484	54325484	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:54325484C>T	uc003gzy.2	+	18	1839	c.1653C>T	c.(1651-1653)CGC>CGT	p.R551R	PDGFRA_uc003haa.2_Intron|FIP1L1_uc011bzu.1_Silent_p.R545R|FIP1L1_uc003gzz.2_Silent_p.R477R|FIP1L1_uc003hab.2_Silent_p.R516R|FIP1L1_uc003hac.2_Silent_p.R305R|FIP1L1_uc010ign.2_RNA|FIP1L1_uc003had.2_Missense_Mutation_p.A136V|FIP1L1_uc003hae.2_Missense_Mutation_p.A139V	NM_030917	NP_112179	Q6UN15	FIP1_HUMAN	FIP1 like 1 isoform 1	551	Arg-rich.|Sufficient for interaction with CPSF1 and CSTF3.|Glu-rich.				mRNA processing	nucleus	RNA binding			ovary(1)|skin(1)	2			GBM - Glioblastoma multiforme(3;3.31e-36)|LUSC - Lung squamous cell carcinoma(32;0.0134)					T	PDGFRA	idiopathic hypereosinophilic syndrome								---	---	---	---
UGT2A3	79799	broad.mit.edu	37	4	69817175	69817175	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:69817175A>T	uc003hef.2	-	1	335	c.304T>A	c.(304-306)TCA>ACA	p.S102T	UGT2A3_uc010ihp.1_RNA	NM_024743	NP_079019	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family,	102	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(1)|skin(1)	2																		---	---	---	---
UGT2A3	79799	broad.mit.edu	37	4	69817265	69817265	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:69817265A>G	uc003hef.2	-	1	245	c.214T>C	c.(214-216)TTG>CTG	p.L72L	UGT2A3_uc010ihp.1_RNA	NM_024743	NP_079019	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family,	72	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(1)|skin(1)	2																		---	---	---	---
AMTN	401138	broad.mit.edu	37	4	71390632	71390632	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:71390632C>A	uc003hfk.1	+	5	337	c.248C>A	c.(247-249)CCA>CAA	p.P83Q	AMTN_uc010ihy.1_Missense_Mutation_p.P82Q	NM_212557	NP_997722	Q6UX39	AMTN_HUMAN	amelotin precursor	83					biomineral tissue development|cell adhesion|odontogenesis of dentine-containing tooth	basal lamina|cell-cell junction				large_intestine(1)|central_nervous_system(1)	2			Lung(101;0.235)															---	---	---	---
CDKL2	8999	broad.mit.edu	37	4	76522205	76522205	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:76522205A>G	uc003hiq.2	-	9	1761	c.1236T>C	c.(1234-1236)ATT>ATC	p.I412I	CDKL2_uc011cbp.1_Silent_p.I412I	NM_003948	NP_003939	Q92772	CDKL2_HUMAN	cyclin-dependent kinase-like 2	412					sex differentiation|signal transduction	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			ovary(2)|stomach(2)|breast(2)|skin(1)	7			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)															---	---	---	---
SHROOM3	57619	broad.mit.edu	37	4	77662420	77662420	+	Missense_Mutation	SNP	G	A	A	rs151102508		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:77662420G>A	uc011cbx.1	+	5	4047	c.3094G>A	c.(3094-3096)GTG>ATG	p.V1032M	SHROOM3_uc011cbz.1_Missense_Mutation_p.V856M|SHROOM3_uc003hkf.1_Missense_Mutation_p.V907M|SHROOM3_uc003hkg.2_Missense_Mutation_p.V810M	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	1032					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)															---	---	---	---
PRDM8	56978	broad.mit.edu	37	4	81124490	81124490	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:81124490A>G	uc010ijo.2	+	8	2713	c.1874A>G	c.(1873-1875)AAC>AGC	p.N625S	PRDM8_uc003hmb.3_Missense_Mutation_p.N625S|PRDM8_uc003hmc.3_Missense_Mutation_p.N625S	NM_020226	NP_064611	Q9NQV8	PRDM8_HUMAN	PR domain containing 8	625	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1																		---	---	---	---
HNRPDL	9987	broad.mit.edu	37	4	83348411	83348411	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:83348411T>G	uc003hmr.2	-	5	1488	c.953A>C	c.(952-954)CAG>CCG	p.Q318P	HNRPDL_uc003hmq.2_RNA|HNRPDL_uc003hms.2_RNA|HNRPDL_uc003hmt.2_Missense_Mutation_p.Q318P	NM_031372	NP_112740	O14979	HNRDL_HUMAN	heterogeneous nuclear ribonucleoprotein D-like	318	Poly-Gln.				regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	cytoplasm|heterogeneous nuclear ribonucleoprotein complex	double-stranded DNA binding|nucleotide binding|poly(A) RNA binding|protein binding|single-stranded DNA binding			skin(1)	1		Hepatocellular(203;0.114)																---	---	---	---
SEC31A	22872	broad.mit.edu	37	4	83770124	83770124	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:83770124T>A	uc003hnf.2	-	20	2499	c.2335A>T	c.(2335-2337)ATC>TTC	p.I779F	SEC31A_uc003hne.2_Missense_Mutation_p.I512F|SEC31A_uc011ccl.1_Missense_Mutation_p.I740F|SEC31A_uc003hnl.2_Missense_Mutation_p.I740F|SEC31A_uc003hng.2_Missense_Mutation_p.I779F|SEC31A_uc003hnh.2_Missense_Mutation_p.I779F|SEC31A_uc003hni.2_Missense_Mutation_p.I779F|SEC31A_uc003hnj.2_Missense_Mutation_p.I740F|SEC31A_uc011ccm.1_Missense_Mutation_p.I774F|SEC31A_uc011ccn.1_Missense_Mutation_p.I779F|SEC31A_uc003hnk.2_Missense_Mutation_p.I740F|SEC31A_uc003hnm.2_Missense_Mutation_p.I779F|SEC31A_uc003hnn.1_Missense_Mutation_p.I779F	NM_001077207	NP_001070675	O94979	SC31A_HUMAN	SEC31 homolog A isoform 1	779					COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/JAK2(4)|SEC31A/ALK(3)	haematopoietic_and_lymphoid_tissue(4)|soft_tissue(3)|breast(1)	8		Hepatocellular(203;0.114)																---	---	---	---
COPS4	51138	broad.mit.edu	37	4	83978203	83978203	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:83978203A>G	uc003hoa.2	+	5	674	c.535A>G	c.(535-537)ACC>GCC	p.T179A	COPS4_uc003hob.2_Missense_Mutation_p.T179A|COPS4_uc010ijw.2_Missense_Mutation_p.T179A|COPS4_uc010ijx.2_Missense_Mutation_p.T179A	NM_016129	NP_057213	Q9BT78	CSN4_HUMAN	COP9 signalosome subunit 4	179					cullin deneddylation	cytoplasm|signalosome	protein binding			kidney(1)	1		Hepatocellular(203;0.114)																---	---	---	---
PLAC8	51316	broad.mit.edu	37	4	84015872	84015872	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:84015872T>C	uc003hoe.2	-	4	477	c.316A>G	c.(316-318)ATC>GTC	p.I106V	PLAC8_uc011cco.1_Missense_Mutation_p.I106V|PLAC8_uc010ijy.2_RNA|PLAC8_uc010ijz.2_RNA|PLAC8_uc003hod.2_Missense_Mutation_p.I106V	NM_001130716	NP_001124188	Q9NZF1	PLAC8_HUMAN	placenta-specific 8	106										ovary(1)	1		Hepatocellular(203;0.114)																---	---	---	---
FAM175A	84142	broad.mit.edu	37	4	84383916	84383916	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:84383916G>T	uc003hou.2	-	9	1001	c.936C>A	c.(934-936)AAC>AAA	p.N312K	MRPS18C_uc011ccu.1_Intron|FAM175A_uc003hot.2_Missense_Mutation_p.N140K|FAM175A_uc003hov.2_Missense_Mutation_p.N203K	NM_139076	NP_620775	Q6UWZ7	F175A_HUMAN	coiled-coil domain containing 98	312					chromatin modification|double-strand break repair|G2/M transition DNA damage checkpoint|positive regulation of DNA repair|response to ionizing radiation	BRCA1-A complex	polyubiquitin binding			kidney(1)	1																		---	---	---	---
WDFY3	23001	broad.mit.edu	37	4	85708820	85708820	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:85708820G>T	uc003hpd.2	-	23	4124	c.3716C>A	c.(3715-3717)CCA>CAA	p.P1239Q		NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	1239						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)														---	---	---	---
SPP1	6696	broad.mit.edu	37	4	88902839	88902839	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:88902839C>T	uc003hra.2	+	6	594	c.429C>T	c.(427-429)ACC>ACT	p.T143T	SPP1_uc003hrb.2_Silent_p.T116T|SPP1_uc003hrc.2_Silent_p.T129T|SPP1_uc011cde.1_Silent_p.T156T|SPP1_uc003hrd.2_Silent_p.T102T	NM_001040058	NP_001035147	P10451	OSTP_HUMAN	secreted phosphoprotein 1 isoform a	143					biomineral tissue development|cell adhesion|decidualization|embryo implantation|ossification|response to vitamin D	extracellular space	cytokine activity			ovary(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-05)														---	---	---	---
ABCG2	9429	broad.mit.edu	37	4	89052253	89052253	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:89052253A>G	uc003hrg.2	-	5	984	c.491T>C	c.(490-492)GTC>GCC	p.V164A	ABCG2_uc003hrh.2_Missense_Mutation_p.V164A|ABCG2_uc003hrf.2_Missense_Mutation_p.V34A	NM_004827	NP_004818	Q9UNQ0	ABCG2_HUMAN	ATP-binding cassette, sub-family G, member 2	164	ABC transporter.|Cytoplasmic (Potential).				cellular iron ion homeostasis|urate metabolic process	integral to membrane|plasma membrane	ATP binding|heme transporter activity|protein homodimerization activity|xenobiotic-transporting ATPase activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;7.02e-05)	Imatinib(DB00619)|Mitoxantrone(DB01204)|Nicardipine(DB00622)|Nitrendipine(DB01054)|Rosuvastatin(DB01098)|Saquinavir(DB01232)|Topotecan(DB01030)													---	---	---	---
HERC3	8916	broad.mit.edu	37	4	89589160	89589160	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:89589160T>C	uc003hrw.1	+	14	1727	c.1561T>C	c.(1561-1563)TAT>CAT	p.Y521H	HERC3_uc011cdn.1_Missense_Mutation_p.Y403H|HERC3_uc011cdo.1_Intron	NM_014606	NP_055421	Q15034	HERC3_HUMAN	hect domain and RLD 3	521					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasmic membrane-bounded vesicle	ubiquitin-protein ligase activity			lung(2)|prostate(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(123;0.000319)														---	---	---	---
GRID2	2895	broad.mit.edu	37	4	94316827	94316827	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:94316827C>T	uc011cdt.1	+	9	1573	c.1315C>T	c.(1315-1317)CGT>TGT	p.R439C	GRID2_uc011cdu.1_Missense_Mutation_p.R344C	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	439	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)													---	---	---	---
BANK1	55024	broad.mit.edu	37	4	102951225	102951225	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:102951225A>G	uc003hvy.3	+	10	1977	c.1703A>G	c.(1702-1704)GAA>GGA	p.E568G	BANK1_uc003hvx.3_Missense_Mutation_p.E553G|BANK1_uc010ill.2_Missense_Mutation_p.E435G|BANK1_uc003hvz.3_Missense_Mutation_p.E538G	NM_017935	NP_060405	Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	568					B cell activation					ovary(2)|skin(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)														---	---	---	---
TACR3	6870	broad.mit.edu	37	4	104640758	104640758	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:104640758G>A	uc003hxe.1	-	1	218	c.75C>T	c.(73-75)ACC>ACT	p.T25T		NM_001059	NP_001050	P29371	NK3R_HUMAN	tachykinin receptor 3	25	Extracellular (Potential).					integral to plasma membrane	tachykinin receptor activity			ovary(3)|lung(2)|breast(1)|skin(1)	7		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)														---	---	---	---
GSTCD	79807	broad.mit.edu	37	4	106755632	106755632	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:106755632T>C	uc003hxz.3	+	9	1617	c.1545T>C	c.(1543-1545)GCT>GCC	p.A515A	GSTCD_uc003hxy.3_Silent_p.A428A|GSTCD_uc011cfb.1_Silent_p.A138A	NM_001031720	NP_001026890	Q8NEC7	GSTCD_HUMAN	glutathione S-transferase, C-terminal domain	515						cytoplasm	rRNA methyltransferase activity			breast(1)|central_nervous_system(1)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.15e-07)|READ - Rectum adenocarcinoma(30;0.139)														---	---	---	---
SEC24B	10427	broad.mit.edu	37	4	110459743	110459743	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:110459743A>G	uc003hzk.2	+	23	3738	c.3683A>G	c.(3682-3684)CAC>CGC	p.H1228R	SEC24B_uc003hzl.2_Missense_Mutation_p.H1193R|SEC24B_uc011cfp.1_Missense_Mutation_p.H1258R|SEC24B_uc011cfq.1_Missense_Mutation_p.H1227R|SEC24B_uc011cfr.1_Missense_Mutation_p.H1192R	NM_006323	NP_006314	O95487	SC24B_HUMAN	SEC24 (S. cerevisiae) homolog B isoform a	1228					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)														---	---	---	---
ENPEP	2028	broad.mit.edu	37	4	111409763	111409763	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:111409763C>A	uc003iab.3	+	2	1053	c.711C>A	c.(709-711)CCC>CCA	p.P237P		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	237	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)													---	---	---	---
C4orf21	55345	broad.mit.edu	37	4	113539998	113539998	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:113539998C>A	uc003iau.2	-	6	1411	c.1200G>T	c.(1198-1200)CAG>CAT	p.Q400H	C4orf21_uc003iaw.2_Missense_Mutation_p.Q400H	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	Error:Variant_position_missing_in_Q6ZU11_after_alignment						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)														---	---	---	---
ARSJ	79642	broad.mit.edu	37	4	114824636	114824636	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:114824636A>G	uc003ibq.1	-	2	1482	c.594T>C	c.(592-594)GGT>GGC	p.G198G	ARSJ_uc010imu.1_Silent_p.G198G|ARSJ_uc010imv.1_Silent_p.G26G	NM_024590	NP_078866	Q5FYB0	ARSJ_HUMAN	arylsulfatase J precursor	198						extracellular region	arylsulfatase activity|metal ion binding			ovary(1)	1		Ovarian(17;0.0035)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00194)														---	---	---	---
SEC24D	9871	broad.mit.edu	37	4	119726993	119726993	+	Intron	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:119726993A>G	uc003ici.3	-						SEC24D_uc003icj.3_Intron|SEC24D_uc003icl.2_Intron|SEC24D_uc010imz.1_Intron|SEC24D_uc011cgg.1_Intron	NM_014822	NP_055637			Sec24-related protein D						COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0																		---	---	---	---
SYNPO2	171024	broad.mit.edu	37	4	119951132	119951132	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:119951132G>A	uc003icm.3	+	4	1398	c.1202G>A	c.(1201-1203)CGT>CAT	p.R401H	SYNPO2_uc010ina.2_Missense_Mutation_p.R401H|SYNPO2_uc010inb.2_Missense_Mutation_p.R401H|SYNPO2_uc011cgh.1_Intron|SYNPO2_uc010inc.2_Missense_Mutation_p.R329H	NM_001128933	NP_001122405	Q9UMS6	SYNP2_HUMAN	synaptopodin 2 isoform b	401	Poly-Arg.					nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			ovary(2)	2																		---	---	---	---
PDE5A	8654	broad.mit.edu	37	4	120427073	120427073	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:120427073A>G	uc003idh.2	-	17	2359	c.2204T>C	c.(2203-2205)TTT>TCT	p.F735S	uc003ide.3_Intron|PDE5A_uc003idf.2_Missense_Mutation_p.F693S|PDE5A_uc003idg.2_Missense_Mutation_p.F683S	NM_001083	NP_001074	O76074	PDE5A_HUMAN	phosphodiesterase 5A isoform 1	735	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|zinc ion binding				0					Dipyridamole(DB00975)|Pentoxifylline(DB00806)|Sildenafil(DB00203)|Tadalafil(DB00820)|Theophylline(DB00277)|Vardenafil(DB00862)													---	---	---	---
TNIP3	79931	broad.mit.edu	37	4	122075732	122075732	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:122075732C>T	uc010ing.2	-	5	662	c.466G>A	c.(466-468)GAA>AAA	p.E156K	TNIP3_uc010inh.2_Missense_Mutation_p.E156K|TNIP3_uc011cgj.1_Missense_Mutation_p.E214K|TNIP3_uc010ini.2_Missense_Mutation_p.E156K	NM_024873	NP_079149	Q96KP6	TNIP3_HUMAN	TNFAIP3 interacting protein 3	156	Potential.									ovary(1)	1																		---	---	---	---
TMEM155	132332	broad.mit.edu	37	4	122682762	122682762	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:122682762G>A	uc003idx.1	-	5	702	c.143C>T	c.(142-144)GCT>GTT	p.A48V	TMEM155_uc003idy.1_Missense_Mutation_p.A48V	NM_152399	NP_689612	Q4W5P6	TM155_HUMAN	transmembrane protein 155 precursor	48						extracellular region					0																		---	---	---	---
TRPC3	7222	broad.mit.edu	37	4	122853842	122853842	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:122853842C>T	uc003ieg.2	-	2	645	c.571G>A	c.(571-573)GTA>ATA	p.V191I	TRPC3_uc010inr.2_Missense_Mutation_p.V118I|TRPC3_uc003ief.2_Missense_Mutation_p.V118I|TRPC3_uc011cgl.1_5'UTR	NM_001130698	NP_001124170	Q13507	TRPC3_HUMAN	transient receptor potential cation channel,	106	Cytoplasmic (Potential).|ANK 3.				axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2																		---	---	---	---
FAT4	79633	broad.mit.edu	37	4	126239277	126239277	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:126239277A>C	uc003ifj.3	+	1	1711	c.1711A>C	c.(1711-1713)ACT>CCT	p.T571P		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	571	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18																OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
FAT4	79633	broad.mit.edu	37	4	126371710	126371710	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:126371710T>C	uc003ifj.3	+	9	9539	c.9539T>C	c.(9538-9540)GTG>GCG	p.V3180A	FAT4_uc011cgp.1_Missense_Mutation_p.V1478A|FAT4_uc003ifi.1_Missense_Mutation_p.V658A	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3180	Cadherin 30.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18																		---	---	---	---
FAT4	79633	broad.mit.edu	37	4	126373095	126373095	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:126373095G>A	uc003ifj.3	+	9	10924	c.10924G>A	c.(10924-10926)GAT>AAT	p.D3642N	FAT4_uc011cgp.1_Missense_Mutation_p.D1940N|FAT4_uc003ifi.1_Missense_Mutation_p.D1120N	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3642	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18																		---	---	---	---
PLK4	10733	broad.mit.edu	37	4	128814517	128814517	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:128814517A>G	uc003ifo.2	+	11	2511	c.2266A>G	c.(2266-2268)AGT>GGT	p.S756G	PLK4_uc011cgs.1_Missense_Mutation_p.S724G|PLK4_uc011cgt.1_Missense_Mutation_p.S715G	NM_014264	NP_055079	O00444	PLK4_HUMAN	polo-like kinase 4	756					G2/M transition of mitotic cell cycle|positive regulation of centriole replication|trophoblast giant cell differentiation	centriole|cleavage furrow|cytosol|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0																		---	---	---	---
PCDH10	57575	broad.mit.edu	37	4	134072897	134072897	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:134072897G>A	uc003iha.2	+	1	2428	c.1602G>A	c.(1600-1602)GAG>GAA	p.E534E	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Silent_p.E534E	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	534	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)														---	---	---	---
MAML3	55534	broad.mit.edu	37	4	140641268	140641268	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:140641268T>C	uc003ihz.1	-	7	3363	c.2611A>G	c.(2611-2613)ACA>GCA	p.T871A	MGST2_uc010ioi.1_Intron|MAML3_uc011chd.1_Missense_Mutation_p.T339A	NM_018717	NP_061187	Q96JK9	MAML3_HUMAN	mastermind-like 3	872	Gln-rich.				Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			ovary(1)	1	all_hematologic(180;0.162)																	---	---	---	---
ANAPC10	10393	broad.mit.edu	37	4	145916687	145916687	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:145916687A>G	uc003iju.3	-	6	551	c.396T>C	c.(394-396)ACT>ACC	p.T132T	ANAPC10_uc003ijv.3_Silent_p.T132T|ANAPC10_uc003ijw.3_Silent_p.T132T	NM_014885	NP_055700	Q9UM13	APC10_HUMAN	anaphase promoting complex subunit 10	132	DOC.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G2/M transition of mitotic cell cycle|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	ubiquitin-protein ligase activity				0	all_hematologic(180;0.151)																	---	---	---	---
OTUD4	54726	broad.mit.edu	37	4	146072045	146072045	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:146072045C>A	uc003ika.3	-	12	924	c.786G>T	c.(784-786)AAG>AAT	p.K262N	OTUD4_uc003ijz.3_Missense_Mutation_p.K261N	NM_001102653	NP_001096123	Q01804	OTUD4_HUMAN	OTU domain containing 4 protein isoform 3	326							protein binding			ovary(2)|breast(1)	3	all_hematologic(180;0.151)																	---	---	---	---
TMEM184C	55751	broad.mit.edu	37	4	148555054	148555054	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:148555054A>G	uc003ila.3	+	9	1587	c.1018A>G	c.(1018-1020)AGA>GGA	p.R340G		NM_018241	NP_060711	Q9NVA4	T184C_HUMAN	transmembrane protein 184C	340						integral to membrane					0																		---	---	---	---
FHDC1	85462	broad.mit.edu	37	4	153897218	153897218	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:153897218G>T	uc003inf.2	+	11	2850	c.2775G>T	c.(2773-2775)CGG>CGT	p.R925R		NM_033393	NP_203751	Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	925					actin cytoskeleton organization		actin binding			large_intestine(1)|ovary(1)	2	all_hematologic(180;0.093)																	---	---	---	---
TLR2	7097	broad.mit.edu	37	4	154625490	154625490	+	Silent	SNP	G	A	A	rs150700268		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:154625490G>A	uc003inq.2	+	3	1650	c.1431G>A	c.(1429-1431)CCG>CCA	p.P477P	TLR2_uc003inr.2_Silent_p.P477P|TLR2_uc003ins.2_Silent_p.P477P	NM_003264	NP_003255	O60603	TLR2_HUMAN	toll-like receptor 2 precursor	477	LRR 13.|Extracellular (Potential).				cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			ovary(1)|lung(1)|breast(1)	3	all_hematologic(180;0.093)	Renal(120;0.117)																---	---	---	---
DCHS2	54798	broad.mit.edu	37	4	155163886	155163886	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:155163886A>G	uc003inw.2	-	22	5615	c.5615T>C	c.(5614-5616)CTT>CCT	p.L1872P		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1872	Cadherin 16.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)														---	---	---	---
GLRB	2743	broad.mit.edu	37	4	158060032	158060032	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:158060032T>C	uc003ipj.2	+	7	884	c.682T>C	c.(682-684)TTG>CTG	p.L228L		NM_000824	NP_000815	P48167	GLRB_HUMAN	glycine receptor, beta isoform A precursor	228	Extracellular (Probable).				nervous system development|neuropeptide signaling pathway|startle response	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|protein binding|receptor activity			skin(2)	2	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0564)|COAD - Colon adenocarcinoma(41;0.0642)|Kidney(143;0.0707)	Glycine(DB00145)													---	---	---	---
GRIA2	2891	broad.mit.edu	37	4	158282733	158282733	+	Intron	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:158282733G>A	uc003ipm.3	+						GRIA2_uc011cit.1_Missense_Mutation_p.V732I|GRIA2_uc003ipl.3_Missense_Mutation_p.V779I|GRIA2_uc003ipk.3_Missense_Mutation_p.V732I|GRIA2_uc010iqh.1_RNA|GRIA2_uc011ciu.1_3'UTR|GRIA2_uc011civ.1_RNA|GRIA2_uc011ciw.1_Intron|GRIA2_uc011cix.1_Intron|GRIA2_uc011ciy.1_Missense_Mutation_p.V89I|GRIA2_uc011ciz.1_RNA	NM_001083619	NP_001077088			glutamate receptor, ionotropic, AMPA 2 isoform 2						synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)													---	---	---	---
KLHL2	11275	broad.mit.edu	37	4	166218824	166218824	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:166218824C>T	uc003irb.2	+	7	977	c.718C>T	c.(718-720)CGA>TGA	p.R240*	KLHL2_uc011cjm.1_Nonsense_Mutation_p.R244*|KLHL2_uc003irc.2_Nonsense_Mutation_p.R152*|KLHL2_uc010ira.2_5'UTR	NM_007246	NP_009177	O95198	KLHL2_HUMAN	kelch-like 2, Mayven isoform 1	240					intracellular protein transport	actin cytoskeleton|cytoplasm	actin binding|transporter activity				0	all_hematologic(180;0.221)			GBM - Glioblastoma multiforme(119;2.94e-27)|COAD - Colon adenocarcinoma(41;1.4e-05)|Kidney(143;4.95e-05)|KIRC - Kidney renal clear cell carcinoma(143;0.000927)														---	---	---	---
KLHL2	11275	broad.mit.edu	37	4	166231869	166231869	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:166231869T>C	uc003irb.2	+	10	1463	c.1204T>C	c.(1204-1206)TTA>CTA	p.L402L	KLHL2_uc011cjm.1_Silent_p.L406L|KLHL2_uc003irc.2_Silent_p.L314L|KLHL2_uc010ira.2_Silent_p.L55L	NM_007246	NP_009177	O95198	KLHL2_HUMAN	kelch-like 2, Mayven isoform 1	402	Kelch 3.				intracellular protein transport	actin cytoskeleton|cytoplasm	actin binding|transporter activity				0	all_hematologic(180;0.221)			GBM - Glioblastoma multiforme(119;2.94e-27)|COAD - Colon adenocarcinoma(41;1.4e-05)|Kidney(143;4.95e-05)|KIRC - Kidney renal clear cell carcinoma(143;0.000927)														---	---	---	---
GALNTL6	442117	broad.mit.edu	37	4	173730604	173730604	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:173730604C>A	uc003isv.2	+	6	1382	c.646C>A	c.(646-648)CGT>AGT	p.R216S		NM_001034845	NP_001030017	Q49A17	GLTL6_HUMAN	N-acetylgalactosaminyltransferase-like 6	216	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|ovary(1)|skin(1)	4																		---	---	---	---
GALNTL6	442117	broad.mit.edu	37	4	173804067	173804067	+	Intron	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:173804067C>A	uc003isv.2	+							NM_001034845	NP_001030017			N-acetylgalactosaminyltransferase-like 6							Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|ovary(1)|skin(1)	4																		---	---	---	---
SPCS3	60559	broad.mit.edu	37	4	177241279	177241279	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:177241279G>A	uc003iur.3	+	1	190	c.52G>A	c.(52-54)GTG>ATG	p.V18M		NM_021928	NP_068747	P61009	SPCS3_HUMAN	signal peptidase complex subunit 3	18	Helical; Signal-anchor for type II membrane protein; (Potential).				energy reserve metabolic process|regulation of insulin secretion|signal peptide processing	integral to membrane|microsome|signal peptidase complex	peptidase activity			ovary(1)	1		Breast(14;0.0011)|Prostate(90;0.0129)|Melanoma(52;0.0133)|Renal(120;0.0376)|all_hematologic(60;0.124)		all cancers(43;2.43e-19)|Epithelial(43;1.84e-16)|OV - Ovarian serous cystadenocarcinoma(60;4.51e-09)|GBM - Glioblastoma multiforme(59;0.000142)|STAD - Stomach adenocarcinoma(60;0.00279)|LUSC - Lung squamous cell carcinoma(193;0.0319)														---	---	---	---
ODZ3	55714	broad.mit.edu	37	4	183664526	183664526	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:183664526C>T	uc003ivd.1	+	18	3620	c.3583C>T	c.(3583-3585)CGG>TGG	p.R1195W	ODZ3_uc003ive.1_Missense_Mutation_p.R601W	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	1195	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)														---	---	---	---
ODZ3	55714	broad.mit.edu	37	4	183696226	183696226	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:183696226A>G	uc003ivd.1	+	23	5261	c.5224A>G	c.(5224-5226)AAC>GAC	p.N1742D		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	1742	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)														---	---	---	---
C4orf41	60684	broad.mit.edu	37	4	184614802	184614802	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:184614802T>C	uc003ivx.2	+	21	2474	c.2298T>C	c.(2296-2298)ACT>ACC	p.T766T	C4orf41_uc003ivw.2_Silent_p.T766T|C4orf41_uc010isc.2_Silent_p.T110T|C4orf41_uc003ivy.2_Silent_p.T372T	NM_021942	NP_068761	Q7Z392	CD041_HUMAN	hypothetical protein LOC60684 isoform a	766											0		all_lung(41;4.4e-14)|Lung NSC(41;1.03e-13)|Colorectal(36;0.00139)|all_hematologic(60;0.00756)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.202)		all cancers(43;1.39e-26)|Epithelial(43;2.42e-22)|OV - Ovarian serous cystadenocarcinoma(60;6.85e-10)|GBM - Glioblastoma multiforme(59;6.71e-06)|Colorectal(24;9.67e-06)|STAD - Stomach adenocarcinoma(60;2.36e-05)|COAD - Colon adenocarcinoma(29;7.07e-05)|LUSC - Lung squamous cell carcinoma(40;0.00984)|READ - Rectum adenocarcinoma(43;0.171)														---	---	---	---
PDLIM3	27295	broad.mit.edu	37	4	186423511	186423511	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:186423511G>A	uc003ixw.3	-	8	1156	c.1032C>T	c.(1030-1032)CAC>CAT	p.H344H	PDLIM3_uc003ixx.3_Silent_p.H296H|PDLIM3_uc010isi.2_RNA	NM_014476	NP_055291	Q53GG5	PDLI3_HUMAN	PDZ and LIM domain protein 3 isoform a	344	LIM zinc-binding.					sarcomere	zinc ion binding			ovary(2)	2		all_lung(41;1.03e-13)|Lung NSC(41;2.49e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.00996)|Colorectal(36;0.0161)|all_hematologic(60;0.0592)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.4e-10)|BRCA - Breast invasive adenocarcinoma(30;8.64e-05)|GBM - Glioblastoma multiforme(59;0.000167)|STAD - Stomach adenocarcinoma(60;0.000828)|LUSC - Lung squamous cell carcinoma(40;0.00984)|COAD - Colon adenocarcinoma(29;0.0115)|READ - Rectum adenocarcinoma(43;0.171)														---	---	---	---
FAT1	2195	broad.mit.edu	37	4	187510305	187510305	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:187510305T>C	uc003izf.2	-	27	13396	c.13208A>G	c.(13207-13209)TAT>TGT	p.Y4403C	FAT1_uc010isn.2_Missense_Mutation_p.Y50C|FAT1_uc003ize.2_Missense_Mutation_p.Y294C	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	4403	Cytoplasmic (Potential).				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12															HNSCC(5;0.00058)			---	---	---	---
FAT1	2195	broad.mit.edu	37	4	187530973	187530973	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:187530973A>G	uc003izf.2	-	15	10238	c.10050T>C	c.(10048-10050)CTT>CTC	p.L3350L		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3350	Extracellular (Potential).|Cadherin 31.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12															HNSCC(5;0.00058)			---	---	---	---
FAT1	2195	broad.mit.edu	37	4	187628465	187628465	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:187628465A>G	uc003izf.2	-	2	2705	c.2517T>C	c.(2515-2517)AGT>AGC	p.S839S	FAT1_uc010iso.1_Silent_p.S839S	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	839	Extracellular (Potential).|Cadherin 7.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12															HNSCC(5;0.00058)			---	---	---	---
FRG1	2483	broad.mit.edu	37	4	190878618	190878618	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:190878618A>C	uc003izs.2	+	6	689	c.498A>C	c.(496-498)GAA>GAC	p.E166D		NM_004477	NP_004468	Q14331	FRG1_HUMAN	FSHD region gene 1	166					rRNA processing	Cajal body|catalytic step 2 spliceosome|nuclear speck|nucleolus					0		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;1.73e-30)|Epithelial(3;5.85e-30)|OV - Ovarian serous cystadenocarcinoma(60;5.56e-15)|BRCA - Breast invasive adenocarcinoma(30;9.14e-06)|Lung(3;3.54e-05)|STAD - Stomach adenocarcinoma(60;8.83e-05)|LUSC - Lung squamous cell carcinoma(40;0.000198)|GBM - Glioblastoma multiforme(59;0.00892)|READ - Rectum adenocarcinoma(43;0.161)														---	---	---	---
SLC9A3	6550	broad.mit.edu	37	5	475020	475020	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:475020C>T	uc003jbe.2	-	16	2591	c.2479G>A	c.(2479-2481)GCC>ACC	p.A827T	SLC9A3_uc011clx.1_Missense_Mutation_p.A818T|LOC25845_uc003jbd.2_5'Flank|LOC25845_uc010itb.1_5'Flank	NM_004174	NP_004165	P48764	SL9A3_HUMAN	solute carrier family 9 (sodium/hydrogen	827	Cytoplasmic (Potential).					cell surface|integral to membrane	sodium:hydrogen antiporter activity				0			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)															---	---	---	---
ADAMTS16	170690	broad.mit.edu	37	5	5146476	5146476	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:5146476C>T	uc003jdl.2	+	3	547	c.409C>T	c.(409-411)CAG>TAG	p.Q137*	ADAMTS16_uc003jdk.1_Nonsense_Mutation_p.Q137*|ADAMTS16_uc003jdj.1_Nonsense_Mutation_p.Q137*	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	137					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8																		---	---	---	---
CTNND2	1501	broad.mit.edu	37	5	11159846	11159846	+	Silent	SNP	G	A	A	rs149766664	byFrequency	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:11159846G>A	uc003jfa.1	-	12	2146	c.2001C>T	c.(1999-2001)TGC>TGT	p.C667C	CTNND2_uc010itt.2_Silent_p.C576C|CTNND2_uc011cmy.1_Silent_p.C330C|CTNND2_uc011cmz.1_Silent_p.C234C|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Silent_p.C234C	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	667					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8																		---	---	---	---
DNAH5	1767	broad.mit.edu	37	5	13876895	13876895	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:13876895G>T	uc003jfd.2	-	22	3336	c.3294C>A	c.(3292-3294)CCC>CCA	p.P1098P		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1098	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)													Kartagener_syndrome				---	---	---	---
TRIO	7204	broad.mit.edu	37	5	14378154	14378154	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:14378154G>T	uc003jff.2	+	20	3371	c.3365G>T	c.(3364-3366)AGG>ATG	p.R1122M	TRIO_uc003jfg.2_RNA|TRIO_uc011cna.1_Missense_Mutation_p.R1073M|TRIO_uc003jfh.1_Missense_Mutation_p.R771M	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	1122	Spectrin 4.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)																	---	---	---	---
TRIO	7204	broad.mit.edu	37	5	14498693	14498693	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:14498693G>A	uc003jff.2	+	53	8282	c.8276G>A	c.(8275-8277)TGC>TAC	p.C2759Y	TRIO_uc003jfg.2_RNA	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	2759	Ig-like C2-type.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)																	---	---	---	---
PRDM9	56979	broad.mit.edu	37	5	23527575	23527575	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:23527575G>A	uc003jgo.2	+	11	2560	c.2378G>A	c.(2377-2379)AGT>AAT	p.S793N		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	793	C2H2-type 11.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6															HNSCC(3;0.000094)			---	---	---	---
RNASEN	29102	broad.mit.edu	37	5	31449427	31449427	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:31449427C>T	uc003jhg.2	-	21	3141	c.2782G>A	c.(2782-2784)GGA>AGA	p.G928R	RNASEN_uc003jhh.2_Missense_Mutation_p.G891R|RNASEN_uc003jhi.2_Missense_Mutation_p.G891R	NM_013235	NP_037367	Q9NRR4	RNC_HUMAN	ribonuclease III, nuclear isoform 1	928	Necessary for interaction with DGCR8 and pri-miRNA processing activity.|RNase III 1.				gene silencing by RNA|ribosome biogenesis|RNA processing	nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity				0																		---	---	---	---
C5orf22	55322	broad.mit.edu	37	5	31553019	31553019	+	3'UTR	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:31553019A>G	uc003jhj.3	+	9					C5orf22_uc003jhk.3_3'UTR|C5orf22_uc010iuj.2_3'UTR	NM_018356	NP_060826			hypothetical protein LOC55322											ovary(2)	2																		---	---	---	---
PDZD2	23037	broad.mit.edu	37	5	31983706	31983706	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:31983706C>T	uc003jhl.2	+	3	1310	c.922C>T	c.(922-924)CGC>TGC	p.R308C	PDZD2_uc003jhm.2_Missense_Mutation_p.R308C|PDZD2_uc011cnx.1_Missense_Mutation_p.R134C	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	308					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9																		---	---	---	---
TARS	6897	broad.mit.edu	37	5	33467736	33467736	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:33467736C>T	uc003jhy.2	+	19	2390	c.2095C>T	c.(2095-2097)CGC>TGC	p.R699C	TARS_uc011cob.1_Missense_Mutation_p.R687C|TARS_uc011coc.1_Missense_Mutation_p.R720C|TARS_uc003jhz.2_Missense_Mutation_p.R595C|TARS_uc011cod.1_Missense_Mutation_p.R578C	NM_152295	NP_689508	P26639	SYTC_HUMAN	threonyl-tRNA synthetase	699					threonyl-tRNA aminoacylation	cytosol	ATP binding|protein homodimerization activity|threonine-tRNA ligase activity			ovary(2)	2					L-Threonine(DB00156)													---	---	---	---
PLCXD3	345557	broad.mit.edu	37	5	41382376	41382376	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:41382376T>C	uc003jmm.1	-	2	466	c.364A>G	c.(364-366)AAT>GAT	p.N122D		NM_001005473	NP_001005473	Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X	122	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			skin(2)|urinary_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	6																		---	---	---	---
NNT	23530	broad.mit.edu	37	5	43659315	43659315	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:43659315G>A	uc003joe.2	+	17	2752	c.2497G>A	c.(2497-2499)GTC>ATC	p.V833I	NNT_uc003jof.2_Missense_Mutation_p.V833I	NM_012343	NP_036475	Q13423	NNTM_HUMAN	nicotinamide nucleotide transhydrogenase	833	Helical; (Potential).				tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain	NAD binding|NAD(P)+ transhydrogenase (AB-specific) activity|NAD(P)+ transhydrogenase (B-specific) activity|NADP binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(6;2.58e-06)				NADH(DB00157)													---	---	---	---
PARP8	79668	broad.mit.edu	37	5	50057724	50057724	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:50057724G>A	uc003jon.3	+	7	597	c.415G>A	c.(415-417)GGA>AGA	p.G139R	PARP8_uc011cpz.1_Missense_Mutation_p.G31R|PARP8_uc003joo.2_Missense_Mutation_p.G139R|PARP8_uc003jop.2_Missense_Mutation_p.G139R	NM_024615	NP_078891	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	139						intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)																---	---	---	---
DHX29	54505	broad.mit.edu	37	5	54579187	54579187	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:54579187A>G	uc003jpx.2	-	11	1929	c.1809T>C	c.(1807-1809)ACT>ACC	p.T603T	DHX29_uc010ivw.2_RNA	NM_019030	NP_061903	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	603	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|translation initiation factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)																---	---	---	---
CCNB1	891	broad.mit.edu	37	5	68470154	68470154	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:68470154G>T	uc003jvm.2	+	5	800	c.623G>T	c.(622-624)TGG>TTG	p.W208L	CCNB1_uc011crd.1_Missense_Mutation_p.W208L|CCNB1_uc010ixb.2_Missense_Mutation_p.W208L	NM_031966	NP_114172	P14635	CCNB1_HUMAN	cyclin B1	208					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitotic cell cycle spindle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|mitotic spindle stabilization|positive regulation of attachment of spindle microtubules to kinetochore|positive regulation of mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	condensed nuclear chromosome outer kinetochore|cytosol|microtubule organizing center|nucleoplasm|spindle pole					0		Lung NSC(167;5.51e-05)|Prostate(74;0.00634)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.24e-56)|Epithelial(20;1.12e-52)|all cancers(19;2.63e-48)|Lung(70;0.0177)														---	---	---	---
GCNT4	51301	broad.mit.edu	37	5	74324987	74324987	+	Silent	SNP	G	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:74324987G>C	uc003kdn.2	-	1	1738	c.876C>G	c.(874-876)CCC>CCG	p.P292P		NM_016591	NP_057675	Q9P109	GCNT4_HUMAN	core 2 beta-1,6-N-acetylglucosaminyltransferase	292	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			ovary(2)|skin(1)	3		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;8.44e-57)														---	---	---	---
HMGCR	3156	broad.mit.edu	37	5	74643031	74643031	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:74643031T>C	uc003kdp.2	+	6	609	c.453T>C	c.(451-453)GAT>GAC	p.D151D	HMGCR_uc011cst.1_Silent_p.D171D|HMGCR_uc003kdq.2_Silent_p.D151D|HMGCR_uc010izn.1_5'UTR	NM_000859	NP_000850	P04035	HMDH_HUMAN	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	151					cholesterol biosynthetic process|coenzyme A metabolic process|germ cell migration|gonad development|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal membrane	hydroxymethylglutaryl-CoA reductase (NADPH) activity|NADP binding			ovary(1)	1		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;2.24e-54)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Cerivastatin(DB00439)|Fluvastatin(DB01095)|Lovastatin(DB00227)|NADH(DB00157)|Pravastatin(DB00175)|Rosuvastatin(DB01098)|Simvastatin(DB00641)													---	---	---	---
ATP6AP1L	92270	broad.mit.edu	37	5	81613882	81613882	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:81613882G>A	uc003khv.2	+	10	1763	c.438G>A	c.(436-438)TCG>TCA	p.S146S	ATP6AP1L_uc003khw.2_Silent_p.S146S	NM_001017971	NP_001017971	Q52LC2	VAS1L_HUMAN	ATPase, H+ transporting, lysosomal accessory	146					ATP hydrolysis coupled proton transport	integral to membrane|proton-transporting V-type ATPase, V1 domain	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism				0																		---	---	---	---
RASA1	5921	broad.mit.edu	37	5	86645084	86645084	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:86645084T>C	uc003kiw.2	+	8	1274	c.1156T>C	c.(1156-1158)TAT>CAT	p.Y386H	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_Missense_Mutation_p.Y209H|RASA1_uc011ctv.1_Missense_Mutation_p.Y219H|RASA1_uc011ctw.1_Missense_Mutation_p.Y220H|RASA1_uc010jaw.2_Missense_Mutation_p.Y208H	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	386	SH2 2.				cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)														---	---	---	---
POLR3G	10622	broad.mit.edu	37	5	89783832	89783832	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:89783832C>T	uc003kjq.2	+	3	333	c.133C>T	c.(133-135)CCA>TCA	p.P45S	POLR3G_uc011cuc.1_Missense_Mutation_p.P45S	NM_006467	NP_006458	O15318	RPC7_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	45					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|regulation of transcription from RNA polymerase III promoter|response to virus	DNA-directed RNA polymerase III complex	DNA-directed RNA polymerase activity				0		all_cancers(142;5.03e-09)|all_epithelial(76;1.23e-11)|Lung NSC(167;2.46e-05)|all_lung(232;3.25e-05)|Ovarian(174;0.00832)|Colorectal(57;0.122)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(54;2.74e-31)|Epithelial(54;8.2e-26)|all cancers(79;3.86e-22)														---	---	---	---
RFESD	317671	broad.mit.edu	37	5	94991908	94991908	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:94991908A>G	uc003klf.2	+	5	1761	c.369A>G	c.(367-369)ACA>ACG	p.T123T	RFESD_uc003klg.2_Silent_p.T176T|RFESD_uc011cun.1_Silent_p.T176T|SPATA9_uc010jbh.1_Intron|SPATA9_uc003klh.1_Intron|SPATA9_uc003kli.1_Intron	NM_173362	NP_775498	Q8TAC1	RFESD_HUMAN	Rieske (Fe-S) domain containing isoform 2	123	Rieske 2.						2 iron, 2 sulfur cluster binding|metal ion binding|oxidoreductase activity				0		all_cancers(142;0.000215)|all_epithelial(76;7.43e-07)|all_lung(232;0.0318)|Lung NSC(167;0.041)|Ovarian(225;0.051)|Colorectal(57;0.162)		all cancers(79;5.94e-17)														---	---	---	---
ERAP2	64167	broad.mit.edu	37	5	96239120	96239120	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:96239120T>C	uc003kmq.2	+	13	2578	c.1868T>C	c.(1867-1869)TTT>TCT	p.F623S	uc003kmo.1_Intron|ERAP2_uc003kmt.2_Missense_Mutation_p.F623S|ERAP2_uc003kmr.2_RNA|ERAP2_uc003kms.2_Missense_Mutation_p.F572S|ERAP2_uc003kmu.2_RNA	NM_022350	NP_071745	Q6P179	ERAP2_HUMAN	endoplasmic reticulum aminopeptidase 2	623	Lumenal (Potential).				antigen processing and presentation of endogenous peptide antigen via MHC class I|proteolysis|regulation of blood pressure	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding				0		all_cancers(142;0.000311)|all_epithelial(76;1.54e-06)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0596)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0703)														---	---	---	---
ERAP2	64167	broad.mit.edu	37	5	96253217	96253217	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:96253217T>C	uc003kmq.2	+	19	3501	c.2791T>C	c.(2791-2793)TTT>CTT	p.F931L	uc003kmo.1_Intron|ERAP2_uc003kmt.2_Missense_Mutation_p.F931L|ERAP2_uc003kmr.2_RNA|ERAP2_uc003kms.2_Missense_Mutation_p.F880L|ERAP2_uc003kmu.2_RNA	NM_022350	NP_071745	Q6P179	ERAP2_HUMAN	endoplasmic reticulum aminopeptidase 2	931	Lumenal (Potential).				antigen processing and presentation of endogenous peptide antigen via MHC class I|proteolysis|regulation of blood pressure	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding				0		all_cancers(142;0.000311)|all_epithelial(76;1.54e-06)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0596)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0703)														---	---	---	---
LNPEP	4012	broad.mit.edu	37	5	96362455	96362455	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:96362455T>C	uc003kmv.1	+	16	3372	c.2858T>C	c.(2857-2859)GTA>GCA	p.V953A	LNPEP_uc003kmw.1_Missense_Mutation_p.V939A	NM_005575	NP_005566	Q9UIQ6	LCAP_HUMAN	leucyl/cystinyl aminopeptidase isoform 1	953	Extracellular (Potential).				cell-cell signaling|female pregnancy|proteolysis	extracellular region|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(3)|breast(1)	4		all_cancers(142;7e-07)|all_epithelial(76;9.52e-10)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0269)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.072)														---	---	---	---
ST8SIA4	7903	broad.mit.edu	37	5	100191913	100191913	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:100191913T>C	uc003knk.2	-	4	1019	c.691A>G	c.(691-693)AAA>GAA	p.K231E		NM_005668	NP_005659	Q92187	SIA8D_HUMAN	ST8 alpha-N-acetyl-neuraminide	231	Lumenal (Potential).				axon guidance|N-glycan processing	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			large_intestine(1)|central_nervous_system(1)	2		all_cancers(142;1.5e-07)|all_epithelial(76;1.43e-10)|Prostate(80;0.000644)|Lung NSC(167;0.0059)|all_lung(232;0.00914)|Ovarian(225;0.024)|Colorectal(57;0.09)|Breast(839;0.203)		COAD - Colon adenocarcinoma(37;0.00402)														---	---	---	---
SLCO6A1	133482	broad.mit.edu	37	5	101834428	101834428	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:101834428A>G	uc003knn.2	-	1	293	c.121T>C	c.(121-123)TCC>CCC	p.S41P	SLCO6A1_uc003kno.2_Missense_Mutation_p.S41P|SLCO6A1_uc003knp.2_Missense_Mutation_p.S41P|SLCO6A1_uc003knq.2_Missense_Mutation_p.S41P	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	41	Cytoplasmic (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)														---	---	---	---
GIN1	54826	broad.mit.edu	37	5	102423850	102423850	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:102423850C>G	uc003koa.1	-	8	1403	c.1321G>C	c.(1321-1323)GTA>CTA	p.V441L	GIN1_uc003kob.1_Missense_Mutation_p.V294L|GIN1_uc003koc.1_Missense_Mutation_p.Q222H	NM_017676	NP_060146	Q9NXP7	GIN1_HUMAN	zinc finger, H2C2 domain containing	441					DNA integration		DNA binding			ovary(1)|skin(1)	2		all_cancers(142;3.23e-07)|all_epithelial(76;3.64e-10)|Prostate(80;0.00914)|Ovarian(225;0.0139)|Lung NSC(167;0.0212)|Colorectal(57;0.0249)|all_lung(232;0.0283)		Epithelial(69;3.57e-14)|COAD - Colon adenocarcinoma(37;0.00794)														---	---	---	---
PPIP5K2	23262	broad.mit.edu	37	5	102519007	102519007	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:102519007A>G	uc003kod.3	+	25	3514	c.2995A>G	c.(2995-2997)ACT>GCT	p.T999A	PPIP5K2_uc011cva.1_RNA|PPIP5K2_uc003koe.2_Missense_Mutation_p.T999A|PPIP5K2_uc003kof.2_Intron	NM_015216	NP_056031	O43314	VIP2_HUMAN	Histidine acid phosphatase domain containing 1	999					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			ovary(1)|skin(1)	2																		---	---	---	---
FER	2241	broad.mit.edu	37	5	108294945	108294945	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:108294945G>A	uc003kop.1	+	13	1937	c.1553G>A	c.(1552-1554)GGC>GAC	p.G518D	FER_uc011cvf.1_RNA|FER_uc011cvg.1_Missense_Mutation_p.G343D	NM_005246	NP_005237	P16591	FER_HUMAN	fer (fps/fes related) tyrosine kinase	518	SH2.				intracellular signal transduction|peptidyl-tyrosine phosphorylation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|kidney(1)	5		all_cancers(142;2.86e-06)|all_epithelial(76;9.81e-08)|Prostate(80;0.00972)|Lung NSC(167;0.039)|Ovarian(225;0.0448)|all_lung(232;0.0496)|Colorectal(57;0.0986)|Breast(839;0.152)		OV - Ovarian serous cystadenocarcinoma(64;6.77e-10)|Epithelial(69;4.13e-08)|COAD - Colon adenocarcinoma(37;0.0174)														---	---	---	---
EPB41L4A	64097	broad.mit.edu	37	5	111541212	111541212	+	Intron	SNP	A	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:111541212A>T	uc003kpv.1	-						EPB41L4A_uc003kpp.1_Intron	NM_022140	NP_071423			erythrocyte protein band 4.1-like 4							cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			ovary(1)	1		all_cancers(142;4.93e-06)|all_epithelial(76;2.28e-08)|Prostate(80;0.000244)|Colorectal(10;0.000788)|Ovarian(225;0.0448)|Lung NSC(167;0.126)|all_lung(232;0.135)		OV - Ovarian serous cystadenocarcinoma(64;6.24e-09)|Epithelial(69;1.43e-07)|all cancers(49;2.78e-05)|COAD - Colon adenocarcinoma(37;0.0467)|Colorectal(14;0.0791)														---	---	---	---
APC	324	broad.mit.edu	37	5	112178834	112178834	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:112178834A>G	uc010jby.2	+	16	7923	c.7543A>G	c.(7543-7545)ATA>GTA	p.I2515V	APC_uc011cvt.1_Missense_Mutation_p.I2497V|APC_uc003kpz.3_Missense_Mutation_p.I2515V|APC_uc003kpy.3_Missense_Mutation_p.I2515V|APC_uc010jbz.2_Missense_Mutation_p.I2232V|APC_uc010jca.2_Missense_Mutation_p.I1815V	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	2515	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)			12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			---	---	---	---
FEM1C	56929	broad.mit.edu	37	5	114861055	114861055	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:114861055G>T	uc003krb.1	-	3	1366	c.804C>A	c.(802-804)TAC>TAA	p.Y268*		NM_020177	NP_064562	Q96JP0	FEM1C_HUMAN	feminization 1 homolog a	268	TPR 1.					cytoplasm				breast(2)|ovary(1)	3		all_cancers(142;0.000575)|all_epithelial(76;9.98e-06)|Prostate(80;0.00955)|Ovarian(225;0.0443)|all_lung(232;0.132)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;2.5e-07)|Epithelial(69;2.66e-07)|all cancers(49;1.39e-05)														---	---	---	---
FBN2	2201	broad.mit.edu	37	5	127670530	127670530	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:127670530T>C	uc003kuu.2	-	31	4419	c.3980A>G	c.(3979-3981)AAT>AGT	p.N1327S	FBN2_uc003kuv.2_Missense_Mutation_p.N1294S	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1327	EGF-like 21; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)														---	---	---	---
ADAMTS19	171019	broad.mit.edu	37	5	128977572	128977572	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:128977572A>G	uc003kvb.1	+	11	1773	c.1773A>G	c.(1771-1773)TTA>TTG	p.L591L	ADAMTS19_uc010jdh.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	591	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)														---	---	---	---
RAPGEF6	51735	broad.mit.edu	37	5	130897705	130897705	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:130897705T>C	uc003kvn.1	-	5	523	c.317A>G	c.(316-318)GAT>GGT	p.D106G	RAPGEF6_uc003kvp.1_Missense_Mutation_p.D156G|RAPGEF6_uc003kvo.1_Missense_Mutation_p.D106G|RAPGEF6_uc010jdi.1_Missense_Mutation_p.D106G|RAPGEF6_uc010jdj.1_Missense_Mutation_p.D106G|RAPGEF6_uc003kvr.2_Missense_Mutation_p.D106G|RAPGEF6_uc011cxe.1_RNA|RAPGEF6_uc010jdk.2_Missense_Mutation_p.D106G	NM_016340	NP_057424	Q8TEU7	RPGF6_HUMAN	PDZ domain-containing guanine nucleotide	106					Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			ovary(1)|lung(1)|central_nervous_system(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)														---	---	---	---
AFF4	27125	broad.mit.edu	37	5	132216839	132216839	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:132216839A>C	uc003kyd.2	-	21	3812	c.3404T>G	c.(3403-3405)ATC>AGC	p.I1135S	AFF4_uc011cxk.1_Missense_Mutation_p.I813S	NM_014423	NP_055238	Q9UHB7	AFF4_HUMAN	ALL1 fused gene from 5q31	1135					transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|kidney(2)|skin(1)	5		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)															---	---	---	---
HSPA4	3308	broad.mit.edu	37	5	132424849	132424849	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:132424849T>C	uc003kyj.2	+	10	1521	c.1240T>C	c.(1240-1242)TCA>CCA	p.S414P		NM_002154	NP_002145	P34932	HSP74_HUMAN	heat shock 70kDa protein 4	414					cellular chaperone-mediated protein complex assembly|protein import into mitochondrial outer membrane|response to unfolded protein	cytoplasm|nucleus	ATP binding			lung(1)|breast(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)															---	---	---	---
HSPA4	3308	broad.mit.edu	37	5	132426873	132426873	+	Intron	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:132426873G>A	uc003kyj.2	+							NM_002154	NP_002145			heat shock 70kDa protein 4						cellular chaperone-mediated protein complex assembly|protein import into mitochondrial outer membrane|response to unfolded protein	cytoplasm|nucleus	ATP binding			lung(1)|breast(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)															---	---	---	---
CDKN2AIPNL	91368	broad.mit.edu	37	5	133738594	133738594	+	3'UTR	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:133738594A>G	uc011cxs.1	-	3						NM_080656	NP_542387			CDKN2A interacting protein N-terminal like												0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)															---	---	---	---
PHF15	23338	broad.mit.edu	37	5	133914438	133914438	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:133914438G>A	uc003kzo.1	+	11	1983	c.1804G>A	c.(1804-1806)GCC>ACC	p.A602T	PHF15_uc011cxt.1_Missense_Mutation_p.A646T|PHF15_uc003kzk.2_Missense_Mutation_p.A662T|PHF15_uc003kzl.2_3'UTR|PHF15_uc003kzm.2_Missense_Mutation_p.A603T|PHF15_uc003kzn.2_3'UTR	NM_015288	NP_056103	Q9NQC1	JADE2_HUMAN	PHD finger protein 15	602	Pro-rich.				histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)															---	---	---	---
BRD8	10902	broad.mit.edu	37	5	137500697	137500697	+	Silent	SNP	C	A	A	rs116382389	byFrequency	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:137500697C>A	uc003lcf.1	-	12	1492	c.1437G>T	c.(1435-1437)ACG>ACT	p.T479T	BRD8_uc003lcc.1_RNA|BRD8_uc011cyl.1_Silent_p.T258T|BRD8_uc003lcg.2_Silent_p.T552T|BRD8_uc003lci.2_Silent_p.T482T|BRD8_uc003lch.2_Silent_p.T373T|BRD8_uc011cym.1_Silent_p.T463T|BRD8_uc010jer.1_Silent_p.T448T|BRD8_uc011cyn.1_Silent_p.T438T	NM_139199	NP_631938	Q9H0E9	BRD8_HUMAN	bromodomain containing 8 isoform 2	479					cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)															---	---	---	---
DND1	373863	broad.mit.edu	37	5	140052333	140052333	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140052333C>T	uc003lgt.2	-	3	345	c.301G>A	c.(301-303)GCC>ACC	p.A101T		NM_194249	NP_919225	Q8IYX4	DND1_HUMAN	dead end homolog 1	101	RRM 1.				multicellular organismal development|negative regulation of gene silencing by miRNA	cytoplasm|nucleus	AU-rich element binding|nucleotide binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHA1	56147	broad.mit.edu	37	5	140167327	140167327	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140167327G>A	uc003lhb.2	+	1	1452	c.1452G>A	c.(1450-1452)GCG>GCA	p.A484A	PCDHA1_uc003lha.2_Silent_p.A484A|PCDHA1_uc003lgz.2_Silent_p.A484A	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	484	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHA1	56147	broad.mit.edu	37	5	140167916	140167916	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140167916C>T	uc003lhb.2	+	1	2041	c.2041C>T	c.(2041-2043)CGG>TGG	p.R681W	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lgz.2_Missense_Mutation_p.R681W	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	681	Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHA8	56140	broad.mit.edu	37	5	140222665	140222665	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140222665G>A	uc003lhs.2	+	1	1759	c.1759G>A	c.(1759-1761)GCG>ACG	p.A587T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Missense_Mutation_p.A587T	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	587	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHA8	56140	broad.mit.edu	37	5	140223022	140223022	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140223022G>A	uc003lhs.2	+	1	2116	c.2116G>A	c.(2116-2118)GCG>ACG	p.A706T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Missense_Mutation_p.A706T	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	706	Helical; (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHA11	56138	broad.mit.edu	37	5	140249146	140249146	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140249146C>A	uc003lia.2	+	1	1316	c.458C>A	c.(457-459)CCA>CAA	p.P153Q	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.P153Q	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	153	Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHA12	56137	broad.mit.edu	37	5	140256340	140256340	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140256340G>T	uc003lic.2	+	1	1410	c.1283G>T	c.(1282-1284)CGG>CTG	p.R428L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Missense_Mutation_p.R428L	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	428	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHA12	56137	broad.mit.edu	37	5	140256640	140256640	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140256640T>C	uc003lic.2	+	1	1710	c.1583T>C	c.(1582-1584)CTG>CCG	p.L528P	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Missense_Mutation_p.L528P	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	528	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHA12	56137	broad.mit.edu	37	5	140256803	140256803	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140256803G>A	uc003lic.2	+	1	1873	c.1746G>A	c.(1744-1746)CCG>CCA	p.P582P	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Silent_p.P582P	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	582	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHB6	56130	broad.mit.edu	37	5	140531520	140531520	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140531520A>G	uc003lir.2	+	1	1682	c.1682A>G	c.(1681-1683)TAC>TGC	p.Y561C	PCDHB6_uc011dah.1_Missense_Mutation_p.Y425C	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	561	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)															---	---	---	---
PCDHB7	56129	broad.mit.edu	37	5	140554460	140554460	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140554460A>G	uc003lit.2	+	1	2218	c.2044A>G	c.(2044-2046)AAC>GAC	p.N682D	PCDHB8_uc011dai.1_5'Flank	NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	682	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)															---	---	---	---
PCDHB7	56129	broad.mit.edu	37	5	140554465	140554465	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140554465G>T	uc003lit.2	+	1	2223	c.2049G>T	c.(2047-2049)TCG>TCT	p.S683S	PCDHB8_uc011dai.1_5'Flank	NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	683	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)															---	---	---	---
PCDHB7	56129	broad.mit.edu	37	5	140554522	140554522	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140554522G>A	uc003lit.2	+	1	2280	c.2106G>A	c.(2104-2106)TCG>TCA	p.S702S	PCDHB8_uc011dai.1_5'Flank	NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	702	Helical; (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)															---	---	---	---
PCDHB8	56128	broad.mit.edu	37	5	140559519	140559519	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140559519A>G	uc011dai.1	+	1	2090	c.1904A>G	c.(1903-1905)GAC>GGC	p.D635G	PCDHB16_uc003liv.2_5'Flank|PCDHB16_uc010jfw.1_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	635	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)															---	---	---	---
PCDHB11	56125	broad.mit.edu	37	5	140581561	140581561	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140581561C>T	uc003liy.2	+	1	2214	c.2214C>T	c.(2212-2214)GAC>GAT	p.D738D	PCDHB11_uc011daj.1_Silent_p.D373D	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	738	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)															---	---	---	---
PCDHB14	56122	broad.mit.edu	37	5	140605248	140605248	+	Missense_Mutation	SNP	G	A	A	rs142658705		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140605248G>A	uc003ljb.2	+	1	2171	c.2171G>A	c.(2170-2172)CGC>CAC	p.R724H	PCDHB14_uc011dal.1_Missense_Mutation_p.R571H	NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	protocadherin beta 14 precursor	724	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)															---	---	---	---
PCDHGA6	56109	broad.mit.edu	37	5	140755541	140755541	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140755541G>A	uc003ljy.1	+	1	1891	c.1891G>A	c.(1891-1893)GCC>ACC	p.A631T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Missense_Mutation_p.A631T	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	631	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHGA2	56113	broad.mit.edu	37	5	140780159	140780159	+	Intron	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140780159G>A	uc003ljk.1	+						PCDHGA1_uc003lji.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc011dax.1_5'Flank|PCDHGA9_uc003lkh.1_5'Flank	NM_018915	NP_061738			protocadherin gamma subfamily A, 2 isoform 1						homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHGB6	56100	broad.mit.edu	37	5	140788117	140788117	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140788117T>C	uc003lkj.1	+	1	348	c.348T>C	c.(346-348)ATT>ATC	p.I116I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lki.1_Silent_p.I116I	NM_018926	NP_061749	Q9Y5F9	PCDGI_HUMAN	protocadherin gamma subfamily B, 6 isoform 1	116	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHGC3	5098	broad.mit.edu	37	5	140857618	140857618	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140857618G>A	uc003lkv.1	+	1	2050	c.1935G>A	c.(1933-1935)ACG>ACA	p.T645T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc003lkt.1_Intron|PCDHGC3_uc003lku.1_Silent_p.T645T|PCDHGC3_uc003lkw.1_Intron	NM_002588	NP_002579	Q9UN70	PCDGK_HUMAN	protocadherin gamma subfamily C, 3 isoform 1	645	Extracellular (Potential).|Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)													OREG0016865	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
PCDH12	51294	broad.mit.edu	37	5	141331071	141331071	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:141331071G>T	uc003llx.2	-	2	4176	c.2965C>A	c.(2965-2967)CCA>ACA	p.P989T		NM_016580	NP_057664	Q9NPG4	PCD12_HUMAN	protocadherin 12 precursor	989	Cytoplasmic (Potential).				neuron recognition	integral to plasma membrane	calcium ion binding			ovary(3)	3		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)													OREG0016877	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
RNF14	9604	broad.mit.edu	37	5	141354463	141354463	+	Nonsense_Mutation	SNP	T	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:141354463T>A	uc003lly.2	+	3	288	c.249T>A	c.(247-249)TAT>TAA	p.Y83*	RNF14_uc003llz.2_Nonsense_Mutation_p.Y83*|RNF14_uc003lma.2_Nonsense_Mutation_p.Y83*|RNF14_uc003lmb.2_Intron|RNF14_uc003lmc.2_Nonsense_Mutation_p.Y83*|RNF14_uc011dbg.1_Nonsense_Mutation_p.Y83*|RNF14_uc011dbh.1_Intron|RNF14_uc003lmd.2_Nonsense_Mutation_p.Y83*	NM_183399	NP_899646	Q9UBS8	RNF14_HUMAN	ring finger protein 14 isoform 1	83	RWD.				androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|protein ubiquitination|regulation of androgen receptor signaling pathway|regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|small conjugating protein ligase activity|transcription coactivator activity|zinc ion binding				0		all_hematologic(541;0.0536)|Ovarian(839;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.0407)														---	---	---	---
POU4F3	5459	broad.mit.edu	37	5	145719546	145719546	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:145719546G>A	uc003loa.2	+	2	645	c.556G>A	c.(556-558)GAG>AAG	p.E186K		NM_002700	NP_002691	Q15319	PO4F3_HUMAN	POU class 4 homeobox 3	186	POU-specific.				sensory perception of sound|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)															---	---	---	---
STK32A	202374	broad.mit.edu	37	5	146750335	146750335	+	Splice_Site	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:146750335T>C	uc010jgn.1	+	9	1057	c.777_splice	c.e9+2	p.K259_splice	STK32A_uc003lom.2_Splice_Site_p.K259_splice|STK32A_uc011dbw.1_Splice_Site_p.K259_splice	NM_001112724	NP_001106195			serine/threonine kinase 32A isoform 1								ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
AFAP1L1	134265	broad.mit.edu	37	5	148687114	148687114	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:148687114C>T	uc003lqh.2	+	7	816	c.685C>T	c.(685-687)CGG>TGG	p.R229W	AFAP1L1_uc003lqg.3_Missense_Mutation_p.R229W|AFAP1L1_uc010jgy.2_Missense_Mutation_p.R229W	NM_152406	NP_689619	Q8TED9	AF1L1_HUMAN	actin filament associated protein 1-like 1	229	PH 1.						protein binding			breast(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PDGFRB	5159	broad.mit.edu	37	5	149510153	149510153	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:149510153C>A	uc003lro.2	-	9	1785	c.1316G>T	c.(1315-1317)CGG>CTG	p.R439L	PDGFRB_uc010jhd.2_Missense_Mutation_p.R278L	NM_002609	NP_002600	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor beta	439	Extracellular (Potential).|Ig-like C2-type 5.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			central_nervous_system(4)|lung(4)|breast(3)|stomach(2)|prostate(2)|large_intestine(1)|ovary(1)	17		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)			T	ETV6|TRIP11|HIP1|RAB5EP|H4|NIN|HCMOGT-1|PDE4DIP	MPD|AML|CMML|CML						OREG0016927	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
NDST1	3340	broad.mit.edu	37	5	149907475	149907475	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:149907475A>G	uc003lsk.3	+	3	1125	c.623A>G	c.(622-624)TAC>TGC	p.Y208C	NDST1_uc011dcj.1_Missense_Mutation_p.Y208C|NDST1_uc003lsl.2_Missense_Mutation_p.Y208C	NM_001543	NP_001534	P52848	NDST1_HUMAN	N-deacetylase/N-sulfotransferase (heparan	208	Heparan sulfate N-deacetylase 1.|Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process|inflammatory response	Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			breast(1)|skin(1)	2		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)															---	---	---	---
SYNPO	11346	broad.mit.edu	37	5	150029196	150029196	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:150029196C>A	uc003lsn.2	+	3	2465	c.2091C>A	c.(2089-2091)GCC>GCA	p.A697A	SYNPO_uc003lso.3_Silent_p.A453A|SYNPO_uc003lsp.2_Silent_p.A453A	NM_001109974	NP_001103444	Q8N3V7	SYNPO_HUMAN	synaptopodin isoform B	697					positive regulation of actin filament bundle assembly|regulation of stress fiber assembly	actin cytoskeleton|cytoplasm|dendritic spine|perikaryon|postsynaptic density|postsynaptic membrane|tight junction	actin binding|protein binding			large_intestine(1)	1		Medulloblastoma(196;0.134)|all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)															---	---	---	---
SLC36A3	285641	broad.mit.edu	37	5	150666876	150666876	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:150666876G>T	uc003ltw.2	-	6	1058	c.639C>A	c.(637-639)TCC>TCA	p.S213S	GM2A_uc011dcs.1_Intron|SLC36A3_uc003ltv.2_Silent_p.S198S|SLC36A3_uc003ltx.2_Silent_p.S254S	NM_181774	NP_861439	Q495N2	S36A3_HUMAN	solute carrier family 36, member 3 isoform 2	213	Helical; (Potential).					integral to membrane				ovary(2)|skin(1)	3		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)															---	---	---	---
SLC36A2	153201	broad.mit.edu	37	5	150696535	150696535	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:150696535T>C	uc003lty.2	-	10	1425	c.1295A>G	c.(1294-1296)TAC>TGC	p.Y432C	GM2A_uc011dcs.1_Intron|SLC36A2_uc003ltz.2_RNA|SLC36A2_uc003lua.2_Missense_Mutation_p.Y234C	NM_181776	NP_861441	Q495M3	S36A2_HUMAN	solute carrier family 36, member 2	432	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process	cytoplasm|integral to membrane|plasma membrane	glycine transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)															---	---	---	---
FAT2	2196	broad.mit.edu	37	5	150948143	150948143	+	Missense_Mutation	SNP	A	C	C	rs34180611		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:150948143A>C	uc003lue.3	-	1	363	c.350T>G	c.(349-351)CTC>CGC	p.L117R	GM2A_uc011dcs.1_Intron|FAT2_uc010jhx.1_Missense_Mutation_p.L117R	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	117	Extracellular (Potential).|Cadherin 1.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)															---	---	---	---
G3BP1	10146	broad.mit.edu	37	5	151176797	151176797	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:151176797G>T	uc003lun.2	+	7	720	c.549G>T	c.(547-549)ATG>ATT	p.M183I	G3BP1_uc003lum.2_Missense_Mutation_p.M183I|G3BP1_uc011dcu.1_Missense_Mutation_p.M1I|G3BP1_uc010jhz.2_Missense_Mutation_p.M1I|G3BP1_uc003luq.2_5'UTR	NM_005754	NP_005745	Q13283	G3BP1_HUMAN	Ras-GTPase-activating protein SH3-domain-binding	183	Glu-rich.				Ras protein signal transduction|transport	cytosol|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|endonuclease activity|protein binding|RNA binding			skin(3)|ovary(1)	4		all_hematologic(541;0.0338)|Medulloblastoma(196;0.091)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)															---	---	---	---
GABRG2	2566	broad.mit.edu	37	5	161522498	161522498	+	Intron	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:161522498C>A	uc003lyz.3	+						GABRG2_uc010jjc.2_Intron|GABRG2_uc003lyy.3_Intron|GABRG2_uc011dej.1_Intron	NM_000816	NP_000807			gamma-aminobutyric acid A receptor, gamma 2						gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)														---	---	---	---
GABRG2	2566	broad.mit.edu	37	5	161522524	161522524	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:161522524G>A	uc003lyz.3	+	3	641	c.283G>A	c.(283-285)GAC>AAC	p.D95N	GABRG2_uc010jjc.2_Missense_Mutation_p.D95N|GABRG2_uc003lyy.3_Missense_Mutation_p.D95N|GABRG2_uc011dej.1_5'UTR	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	95	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)														---	---	---	---
FBLL1	345630	broad.mit.edu	37	5	167957476	167957476	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:167957476G>A	uc011dep.1	+	1	895	c.682G>A	c.(682-684)GGG>AGG	p.G228R		NR_024356				RecName: Full=rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1;          EC=2.1.1.-;												0																		---	---	---	---
CCDC99	54908	broad.mit.edu	37	5	169023668	169023668	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:169023668A>G	uc003mae.3	+	8	1274	c.995A>G	c.(994-996)CAT>CGT	p.H332R	CCDC99_uc010jjj.2_Missense_Mutation_p.H261R|CCDC99_uc011deq.1_Missense_Mutation_p.H149R|CCDC99_uc010jjk.2_Missense_Mutation_p.H58R	NM_017785	NP_060255	Q96EA4	SPDLY_HUMAN	coiled-coil domain containing 99	332	Potential.				cell division|establishment of mitotic spindle orientation|mitotic metaphase plate congression|mitotic prometaphase|protein localization to kinetochore	condensed chromosome outer kinetochore|cytosol|microtubule organizing center|nucleus|spindle pole	kinetochore binding|protein binding			ovary(1)|liver(1)	2	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)															---	---	---	---
CCDC99	54908	broad.mit.edu	37	5	169023669	169023669	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:169023669T>C	uc003mae.3	+	8	1275	c.996T>C	c.(994-996)CAT>CAC	p.H332H	CCDC99_uc010jjj.2_Silent_p.H261H|CCDC99_uc011deq.1_Silent_p.H149H|CCDC99_uc010jjk.2_Silent_p.H58H	NM_017785	NP_060255	Q96EA4	SPDLY_HUMAN	coiled-coil domain containing 99	332	Potential.				cell division|establishment of mitotic spindle orientation|mitotic metaphase plate congression|mitotic prometaphase|protein localization to kinetochore	condensed chromosome outer kinetochore|cytosol|microtubule organizing center|nucleus|spindle pole	kinetochore binding|protein binding			ovary(1)|liver(1)	2	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)															---	---	---	---
ERGIC1	57222	broad.mit.edu	37	5	172377747	172377747	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:172377747C>A	uc003mbw.3	+	10	995	c.801C>A	c.(799-801)GCC>GCA	p.A267A	ERGIC1_uc003mby.3_Silent_p.A175A|ERGIC1_uc011dfa.1_Silent_p.A212A|ERGIC1_uc003mca.3_RNA	NM_001031711	NP_001026881	Q969X5	ERGI1_HUMAN	endoplasmic reticulum-golgi intermediate	267	Helical; (Potential).				ER to Golgi vesicle-mediated transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	protein binding			skin(2)|ovary(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00344)|all_lung(126;0.00594)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)															---	---	---	---
STC2	8614	broad.mit.edu	37	5	172750372	172750372	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:172750372C>T	uc003mco.1	-	3	1666	c.356G>A	c.(355-357)GGC>GAC	p.G119D	STC2_uc003mcn.1_Missense_Mutation_p.G34D	NM_003714	NP_003705	O76061	STC2_HUMAN	stanniocalcin 2 precursor	119					cell surface receptor linked signaling pathway|cell-cell signaling	extracellular region	hormone activity			skin(2)|ovary(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00229)|all_lung(126;0.004)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|Ovarian(839;0.223)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)															---	---	---	---
FAF2	23197	broad.mit.edu	37	5	175923649	175923649	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:175923649C>T	uc003mej.3	+	8	877	c.824C>T	c.(823-825)TCA>TTA	p.S275L		NM_014613	NP_055428	Q96CS3	FAF2_HUMAN	UBX domain containing 8	275	Potential.				response to unfolded protein	endoplasmic reticulum|lipid particle	protein binding			ovary(1)	1																		---	---	---	---
NSD1	64324	broad.mit.edu	37	5	176638979	176638979	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:176638979T>C	uc003mfr.3	+	5	3717	c.3579T>C	c.(3577-3579)AGT>AGC	p.S1193S	NSD1_uc003mft.3_Silent_p.S924S|NSD1_uc003mfs.1_Silent_p.S1090S|NSD1_uc011dfx.1_Silent_p.S841S	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1193					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)				T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			---	---	---	---
PDLIM7	9260	broad.mit.edu	37	5	176919648	176919648	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:176919648C>T	uc003mhc.1	-	3	212	c.127G>A	c.(127-129)GGA>AGA	p.G43R	PDLIM7_uc003mha.1_5'Flank|PDLIM7_uc003mhb.1_Missense_Mutation_p.G43R|PDLIM7_uc003mhd.1_5'UTR|PDLIM7_uc003mhe.1_RNA|PDLIM7_uc003mhf.2_Missense_Mutation_p.G43R|PDLIM7_uc003mhg.1_Missense_Mutation_p.G43R	NM_005451	NP_005442	Q9NR12	PDLI7_HUMAN	PDZ and LIM domain 7 isoform 1	43	PDZ.				cell differentiation|multicellular organismal development|ossification|receptor-mediated endocytosis	cytoplasm|focal adhesion	protein binding|zinc ion binding			breast(1)	1	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)															---	---	---	---
RMND5B	64777	broad.mit.edu	37	5	177569706	177569706	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:177569706C>A	uc003mim.2	+	4	442	c.262C>A	c.(262-264)CGA>AGA	p.R88R	RMND5B_uc003min.2_Silent_p.R88R|RMND5B_uc003mio.2_Silent_p.R75R|RMND5B_uc003mip.2_Silent_p.R88R|RMND5B_uc011dgf.1_Silent_p.R88R|RMND5B_uc003miq.2_Silent_p.R28R	NM_022762	NP_073599	Q96G75	RMD5B_HUMAN	required for meiotic nuclear division 5 homolog	88										ovary(1)|skin(1)	2	all_cancers(89;0.00294)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)															---	---	---	---
ZNF354A	6940	broad.mit.edu	37	5	178152390	178152390	+	Silent	SNP	G	A	A	rs113512483	byFrequency	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:178152390G>A	uc003mjj.2	-	4	441	c.243C>T	c.(241-243)GGC>GGT	p.G81G		NM_005649	NP_005640	O60765	Z354A_HUMAN	zinc finger protein 354A	81	KRAB.				regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(1)	3	all_cancers(89;0.000536)|Renal(175;0.000159)|all_epithelial(37;0.000221)|Lung NSC(126;0.00308)|all_lung(126;0.00536)	all_cancers(40;0.0452)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.185)														---	---	---	---
TBC1D9B	23061	broad.mit.edu	37	5	179320205	179320205	+	Intron	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:179320205G>A	uc003mlh.2	-						TBC1D9B_uc003mli.2_Intron|TBC1D9B_uc003mlj.2_Intron	NM_198868	NP_942568			TBC1 domain family, member 9B (with GRAM domain)							integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(1)|skin(1)	2	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)															---	---	---	---
TBC1D9B	23061	broad.mit.edu	37	5	179321503	179321503	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:179321503C>T	uc003mlh.2	-	4	497	c.460G>A	c.(460-462)GAG>AAG	p.E154K	TBC1D9B_uc003mli.2_Missense_Mutation_p.E154K|TBC1D9B_uc003mlj.2_Missense_Mutation_p.E154K	NM_198868	NP_942568	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	154	GRAM 1.					integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(1)|skin(1)	2	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)															---	---	---	---
FLT4	2324	broad.mit.edu	37	5	180057235	180057235	+	Missense_Mutation	SNP	G	A	A	rs148392893		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:180057235G>A	uc003mma.3	-	4	582	c.503C>T	c.(502-504)ACG>ATG	p.T168M	FLT4_uc003mlz.3_Missense_Mutation_p.T168M|FLT4_uc003mmb.1_5'Flank|FLT4_uc011dgy.1_Missense_Mutation_p.T168M|FLT4_uc011dgz.1_Missense_Mutation_p.T168M|FLT4_uc011dha.1_Missense_Mutation_p.R152C	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	168	Ig-like C2-type 2.|Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)									Congenital_Hereditary_Lymphedema				---	---	---	---
BTNL8	79908	broad.mit.edu	37	5	180338563	180338563	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:180338563A>G	uc003mmp.2	+	3	856	c.622A>G	c.(622-624)ATG>GTG	p.M208V	BTNL8_uc003mmq.2_Missense_Mutation_p.M208V|BTNL8_uc011dhg.1_Missense_Mutation_p.M83V|BTNL8_uc010jll.2_Missense_Mutation_p.M208V|BTNL8_uc010jlm.2_Missense_Mutation_p.M92V|BTNL8_uc011dhh.1_Missense_Mutation_p.M24V	NM_001040462	NP_001035552	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8 isoform 2 precursor	208	Ig-like V-type 2.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|skin(1)	2	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)															---	---	---	---
RREB1	6239	broad.mit.edu	37	6	7226755	7226755	+	Missense_Mutation	SNP	G	A	A	rs138181401	byFrequency	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:7226755G>A	uc003mxc.2	+	9	1153	c.763G>A	c.(763-765)GCG>ACG	p.A255T	RREB1_uc003mxb.2_Missense_Mutation_p.A255T|RREB1_uc010jnx.2_Missense_Mutation_p.A255T	NM_001003698	NP_001003698	Q92766	RREB1_HUMAN	ras responsive element binding protein 1 isoform	255	C2H2-type 5.				multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)																---	---	---	---
DSP	1832	broad.mit.edu	37	6	7558359	7558359	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:7558359A>T	uc003mxp.1	+	3	563	c.284A>T	c.(283-285)TAT>TTT	p.Y95F	DSP_uc003mxq.1_Missense_Mutation_p.Y95F	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	95	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)														---	---	---	---
HIVEP1	3096	broad.mit.edu	37	6	12162165	12162165	+	Intron	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:12162165A>G	uc003nac.2	+						HIVEP1_uc011diq.1_Intron	NM_002114	NP_002105			human immunodeficiency virus type I enhancer						transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)																---	---	---	---
PHACTR1	221692	broad.mit.edu	37	6	13230285	13230285	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:13230285G>A	uc010jpc.2	+	10	1583	c.1251G>A	c.(1249-1251)AAG>AAA	p.K417K	PHACTR1_uc011dir.1_Silent_p.K486K|PHACTR1_uc003nag.1_Silent_p.K417K|PHACTR1_uc003nah.1_Silent_p.K417K	NM_030948	NP_112210	Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	417						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity				0	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)															---	---	---	---
GFOD1	54438	broad.mit.edu	37	6	13365589	13365589	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:13365589G>T	uc003nat.1	-	2	1224	c.559C>A	c.(559-561)CTC>ATC	p.L187I	GFOD1_uc003nas.1_Missense_Mutation_p.L84I	NM_018988	NP_061861	Q9NXC2	GFOD1_HUMAN	glucose-fructose oxidoreductase domain	187						extracellular region	binding|oxidoreductase activity			ovary(2)	2	Breast(50;0.0296)|Ovarian(93;0.0454)	all_hematologic(90;0.135)	Epithelial(50;0.0348)|BRCA - Breast invasive adenocarcinoma(129;0.1)|all cancers(50;0.108)															---	---	---	---
SIRT5	23408	broad.mit.edu	37	6	13612106	13612106	+	3'UTR	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:13612106G>T	uc003nay.2	+	10					SIRT5_uc003nax.2_3'UTR|SIRT5_uc011dit.1_3'UTR	NM_012241	NP_036373			sirtuin 5 isoform 1						chromatin silencing|protein ADP-ribosylation|protein deacetylation	mitochondrial intermembrane space|mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|zinc ion binding			skin(2)|upper_aerodigestive_tract(1)	3	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.176)		Suramin(DB04786)													---	---	---	---
KIF13A	63971	broad.mit.edu	37	6	17764503	17764503	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:17764503A>T	uc003ncg.3	-	39	5361	c.5256T>A	c.(5254-5256)GAT>GAA	p.D1752E	KIF13A_uc003ncf.2_Missense_Mutation_p.D1704E|KIF13A_uc003nch.3_Missense_Mutation_p.D1717E|KIF13A_uc003nci.3_Missense_Mutation_p.D1704E|KIF13A_uc003nce.1_Missense_Mutation_p.D303E	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	1752					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)															---	---	---	---
KIF13A	63971	broad.mit.edu	37	6	17764689	17764689	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:17764689G>A	uc003ncg.3	-	39	5175	c.5070C>T	c.(5068-5070)TCC>TCT	p.S1690S	KIF13A_uc003ncf.2_Silent_p.S1642S|KIF13A_uc003nch.3_Silent_p.S1655S|KIF13A_uc003nci.3_Silent_p.S1642S|KIF13A_uc003nce.1_Silent_p.S241S	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	1690					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)															---	---	---	---
NHLRC1	378884	broad.mit.edu	37	6	18122645	18122645	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:18122645C>T	uc003ncl.1	-	1	207	c.193G>A	c.(193-195)GCC>ACC	p.A65T		NM_198586	NP_940988	Q6VVB1	NHLC1_HUMAN	NHL repeat containing 1	65	RING-type.				proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	endoplasmic reticulum|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0	Ovarian(93;0.016)|Breast(50;0.0245)	all_hematologic(90;0.165)	all cancers(50;0.0451)|Epithelial(50;0.0493)															---	---	---	---
KDM1B	221656	broad.mit.edu	37	6	18208394	18208394	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:18208394T>C	uc003nco.1	+	10	1289	c.1214T>C	c.(1213-1215)GTG>GCG	p.V405A	KDM1B_uc003ncn.1_Missense_Mutation_p.V376A	NM_153042	NP_694587	Q8NB78	KDM1B_HUMAN	amine oxidase (flavin containing) domain 1	608					multicellular organismal development|regulation of DNA methylation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-monomethyl-K4 specific)|oxidoreductase activity|zinc ion binding			skin(1)	1																		---	---	---	---
TDP2	51567	broad.mit.edu	37	6	24651211	24651211	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:24651211A>G	uc003nej.2	-	7	919	c.894T>C	c.(892-894)GAT>GAC	p.D298D	TDP2_uc003nei.2_Silent_p.D186D	NM_016614	NP_057698	O95551	TYDP2_HUMAN	TRAF and TNF receptor-associated protein	298					cell surface receptor linked signaling pathway|double-strand break repair	PML body	5'-tyrosyl-DNA phosphodiesterase activity|magnesium ion binding|nuclease activity|protein binding|transcription corepressor activity			ovary(1)|lung(1)	2													Direct_reversal_of_damage|Editing_and_processing_nucleases					---	---	---	---
HIST1H4A	8359	broad.mit.edu	37	6	26022123	26022123	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:26022123T>C	uc003nfq.2	+	1	217	c.217T>C	c.(217-219)TAT>CAT	p.Y73H		NM_003538	NP_003529	P62805	H4_HUMAN	histone cluster 1, H4a	73					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding				0																		---	---	---	---
HIST1H4G	8369	broad.mit.edu	37	6	26246947	26246947	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:26246947C>T	uc003nhf.2	-	1	259	c.259G>A	c.(259-261)GTG>ATG	p.V87M		NM_003547	NP_003538	Q99525	H4G_HUMAN	histone cluster 1, H4g	87					nucleosome assembly	nucleosome|nucleus	DNA binding				0		all_hematologic(11;0.0945)|Acute lymphoblastic leukemia(11;0.167)																---	---	---	---
BTN2A1	11120	broad.mit.edu	37	6	26468539	26468539	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:26468539G>T	uc003nib.1	+	8	1558	c.1346G>T	c.(1345-1347)CGG>CTG	p.R449L	BTN2A1_uc003nic.1_3'UTR|BTN2A1_uc003nid.1_Missense_Mutation_p.R297L|BTN2A1_uc011dko.1_Missense_Mutation_p.R388L|BTN2A1_uc010jqk.1_Missense_Mutation_p.R209L	NM_007049	NP_008980	Q7KYR7	BT2A1_HUMAN	butyrophilin, subfamily 2, member A1 isoform 1	449	Cytoplasmic (Potential).|B30.2/SPRY.				lipid metabolic process	integral to plasma membrane				ovary(1)|skin(1)	2																		---	---	---	---
ABT1	29777	broad.mit.edu	37	6	26598259	26598259	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:26598259G>A	uc003nii.2	+	2	390	c.359G>A	c.(358-360)CGC>CAC	p.R120H		NM_013375	NP_037507	Q9ULW3	ABT1_HUMAN	activator of basal transcription 1	120	RRM.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleolus	DNA binding|nucleotide binding|protein binding|RNA binding|transcription coactivator activity			ovary(1)	1																		---	---	---	---
HIST1H4I	8294	broad.mit.edu	37	6	27107159	27107159	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:27107159C>T	uc003niy.1	+	1	72	c.72C>T	c.(70-72)CGC>CGT	p.R24R	HIST1H2BK_uc003nix.1_Intron	NM_003495	NP_003486	P62805	H4_HUMAN	histone cluster 1, H4i	24					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			lung(1)	1								T	BCL6	NHL								---	---	---	---
HIST1H2BK	85236	broad.mit.edu	37	6	27114460	27114460	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:27114460C>T	uc003nix.1	-	1	160	c.118G>A	c.(118-120)GTA>ATA	p.V40I	HIST1H2AH_uc003niz.2_5'Flank|hsa-mir-3143|MI0014167_5'Flank	NM_080593	NP_542160	O60814	H2B1K_HUMAN	histone cluster 1, H2bk	40					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding				0																		---	---	---	---
ZNF184	7738	broad.mit.edu	37	6	27440058	27440058	+	Intron	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:27440058C>A	uc003njj.2	-						ZNF184_uc010jqv.2_Intron|ZNF184_uc003nji.2_Intron	NM_007149	NP_009080			zinc finger protein 184						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1																		---	---	---	---
ZKSCAN3	80317	broad.mit.edu	37	6	28333883	28333883	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:28333883T>C	uc003nle.3	+	6	1654	c.1438T>C	c.(1438-1440)TAT>CAT	p.Y480H	ZKSCAN3_uc010jrc.2_Missense_Mutation_p.Y480H|ZKSCAN3_uc003nlf.3_Missense_Mutation_p.Y332H|uc010jrd.2_5'Flank	NM_024493	NP_077819	Q9BRR0	ZKSC3_HUMAN	zinc finger with KRAB and SCAN domains 3	480	C2H2-type 6.				positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	chromatin binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2																		---	---	---	---
SCAND3	114821	broad.mit.edu	37	6	28540949	28540949	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:28540949C>T	uc003nlo.2	-	4	3335	c.2717G>A	c.(2716-2718)TGC>TAC	p.C906Y		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	906					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1																		---	---	---	---
OR14J1	442191	broad.mit.edu	37	6	29274633	29274633	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:29274633C>A	uc011dln.1	+	1	167	c.167C>A	c.(166-168)CCC>CAC	p.P56H		NM_030946	NP_112208	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 5, subfamily U member	56	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1																		---	---	---	---
TRIM39	56658	broad.mit.edu	37	6	30297302	30297302	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:30297302C>T	uc010jrz.2	+	3	520	c.208C>T	c.(208-210)CGA>TGA	p.R70*	HCG18_uc003npx.2_5'Flank|HCG18_uc003npy.2_5'Flank|TRIM39_uc003npz.2_Nonsense_Mutation_p.R70*|TRIM39_uc003nqb.2_Nonsense_Mutation_p.R70*|TRIM39_uc003nqc.2_Nonsense_Mutation_p.R70*|TRIM39_uc010jsa.1_Nonsense_Mutation_p.R70*	NM_021253	NP_067076	Q9HCM9	TRI39_HUMAN	tripartite motif-containing 39 isoform 1	70	RING-type.				apoptosis	cytosol|mitochondrion	identical protein binding|zinc ion binding			ovary(3)	3																		---	---	---	---
HLA-E	3133	broad.mit.edu	37	6	30459108	30459108	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:30459108G>T	uc003nqg.2	+	4	843	c.805G>T	c.(805-807)GTG>TTG	p.V269L	HLA-E_uc011dmg.1_RNA|HLA-E_uc011dmh.1_Missense_Mutation_p.V310L	NM_005516	NP_005507	P13747	HLAE_HUMAN	major histocompatibility complex, class I, E	269	Ig-like C1-type.|Alpha-3.|Extracellular (Potential).				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity			central_nervous_system(4)|ovary(1)	5																		---	---	---	---
PSORS1C2	170680	broad.mit.edu	37	6	31105997	31105997	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:31105997G>T	uc003nso.3	-	2	466	c.142C>A	c.(142-144)CCA>ACA	p.P48T	PSORS1C1_uc003nsl.1_Intron|PSORS1C1_uc010jsj.1_Intron|PSORS1C1_uc003nsn.1_Intron	NM_014069	NP_054788	Q9UIG4	PS1C2_HUMAN	SPR1 protein precursor	48						extracellular region					0																		---	---	---	---
SLC44A4	80736	broad.mit.edu	37	6	31838664	31838664	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:31838664C>T	uc010jti.2	-	10	928	c.862G>A	c.(862-864)GCC>ACC	p.A288T	SLC44A4_uc011dol.1_Missense_Mutation_p.A212T|SLC44A4_uc011dom.1_Missense_Mutation_p.A246T	NM_025257	NP_079533	Q53GD3	CTL4_HUMAN	choline transporter-like protein 4	288	Extracellular (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4					Choline(DB00122)													---	---	---	---
SLC44A4	80736	broad.mit.edu	37	6	31838702	31838702	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:31838702T>C	uc010jti.2	-	10	890	c.824A>G	c.(823-825)TAC>TGC	p.Y275C	SLC44A4_uc011dol.1_Missense_Mutation_p.Y199C|SLC44A4_uc011dom.1_Missense_Mutation_p.Y233C	NM_025257	NP_079533	Q53GD3	CTL4_HUMAN	choline transporter-like protein 4	275	Extracellular (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4					Choline(DB00122)													---	---	---	---
CFB	629	broad.mit.edu	37	6	31916154	31916154	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:31916154G>A	uc003nyj.3	+	7	1179	c.901G>A	c.(901-903)GCA>ACA	p.A301T	CFB_uc011dor.1_Missense_Mutation_p.A803T|CFB_uc003nyi.2_Missense_Mutation_p.A301T	NM_001710	NP_001701	P00751	CFAB_HUMAN	complement factor B preproprotein	301	VWFA.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			skin(1)	1																		---	---	---	---
TNXB	7148	broad.mit.edu	37	6	32015707	32015707	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:32015707C>A	uc003nzl.2	-	30	10324	c.10122G>T	c.(10120-10122)ACG>ACT	p.T3374T	TNXB_uc003nzg.1_5'Flank|TNXB_uc003nzh.1_5'Flank	NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	3421	Fibronectin type-III 26.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0																		---	---	---	---
ATF6B	1388	broad.mit.edu	37	6	32083545	32083545	+	Missense_Mutation	SNP	G	T	T	rs139288603		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:32083545G>T	uc003nzn.2	-	18	2116	c.2083C>A	c.(2083-2085)CAC>AAC	p.H695N	TNXB_uc010jts.1_Intron|ATF6B_uc003nzm.1_Intron|ATF6B_uc003nzo.2_Missense_Mutation_p.H692N	NM_004381	NP_004372	Q99941	ATF6B_HUMAN	activating transcription factor 6 beta isoform	695	Lumenal (Potential).				response to unfolded protein|signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0																		---	---	---	---
SLC39A7	7922	broad.mit.edu	37	6	33170162	33170162	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:33170162G>A	uc003odf.2	+	5	874	c.757G>A	c.(757-759)GCT>ACT	p.A253T	RXRB_uc003odb.2_5'Flank|RXRB_uc003odc.2_5'Flank|RXRB_uc003odd.2_5'Flank|RXRB_uc011dqr.1_5'Flank|RXRB_uc011dqs.1_5'Flank|RXRB_uc011dqt.1_5'Flank|RXRB_uc011dqu.1_5'Flank|SLC39A7_uc003odg.2_Missense_Mutation_p.A253T|SLC39A7_uc011dqv.1_Missense_Mutation_p.A128T|SLC39A7_uc003odh.2_5'UTR|HSD17B8_uc003odi.1_5'Flank	NM_001077516	NP_001070984	Q92504	S39A7_HUMAN	solute carrier family 39, member 7	253	His-rich.					endoplasmic reticulum membrane|integral to membrane|membrane fraction	protein binding|zinc ion transmembrane transporter activity			large_intestine(1)	1																		---	---	---	---
KIFC1	3833	broad.mit.edu	37	6	33373349	33373349	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:33373349G>T	uc003oef.3	+	7	1927	c.1477G>T	c.(1477-1479)GGG>TGG	p.G493W	KIFC1_uc011drf.1_Missense_Mutation_p.G485W	NM_002263	NP_002254	Q9BW19	KIFC1_HUMAN	kinesin family member C1	493	Kinesin-motor.				blood coagulation|cell division|microtubule-based movement|mitotic sister chromatid segregation	early endosome|microtubule|microtubule associated complex|microtubule organizing center|nucleus|spindle	ATP binding|microtubule motor activity				0																		---	---	---	---
UHRF1BP1	54887	broad.mit.edu	37	6	34826874	34826874	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:34826874G>T	uc003oju.3	+	14	2975	c.2741G>T	c.(2740-2742)CGG>CTG	p.R914L	UHRF1BP1_uc010jvm.1_RNA|UHRF1BP1_uc010jvn.2_RNA|UHRF1BP1_uc010jvo.2_RNA	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	ICBP90 binding protein 1	914										ovary(3)	3																		---	---	---	---
SFRS3	6428	broad.mit.edu	37	6	36568978	36568978	+	Intron	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:36568978A>G	uc003omj.2	+						SFRS3_uc003omk.2_Intron	NM_003017	NP_003008			splicing factor, arginine/serine-rich 3						mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding				0								T	BCL6	follicular lymphoma								---	---	---	---
CPNE5	57699	broad.mit.edu	37	6	36710137	36710137	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:36710137G>A	uc003omr.1	-	21	1757	c.1690C>T	c.(1690-1692)CGC>TGC	p.R564C	CPNE5_uc003omp.1_Missense_Mutation_p.R272C|CPNE5_uc010jwn.1_Missense_Mutation_p.R214C|CPNE5_uc003omq.1_Missense_Mutation_p.R214C	NM_020939	NP_065990	Q9HCH3	CPNE5_HUMAN	copine V	564										skin(1)	1																		---	---	---	---
KCNK5	8645	broad.mit.edu	37	6	39159204	39159204	+	Missense_Mutation	SNP	G	A	A	rs145388113		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:39159204G>A	uc003oon.2	-	5	1326	c.962C>T	c.(961-963)ACG>ATG	p.T321M		NM_003740	NP_003731	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	321	Cytoplasmic (Potential).				excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|skin(1)	2																		---	---	---	---
PGC	5225	broad.mit.edu	37	6	41704583	41704583	+	3'UTR	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:41704583A>G	uc003ora.1	-	9					TFEB_uc003oqs.1_5'Flank|TFEB_uc003oqt.1_5'Flank|TFEB_uc003oqu.1_5'Flank|TFEB_uc003oqv.1_5'Flank|TFEB_uc010jxo.1_5'Flank|TFEB_uc010jxq.1_5'Flank	NM_002630	NP_002621			progastricsin (pepsinogen C) precursor						digestion|proteolysis	extracellular space	aspartic-type endopeptidase activity				0	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;0.000132)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)															---	---	---	---
TRERF1	55809	broad.mit.edu	37	6	42236421	42236421	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:42236421G>A	uc003osd.2	-	5	1471	c.908C>T	c.(907-909)CCG>CTG	p.P303L	TRERF1_uc011duq.1_Missense_Mutation_p.P303L|TRERF1_uc003osb.2_Missense_Mutation_p.P142L|TRERF1_uc003osc.2_Missense_Mutation_p.P142L|TRERF1_uc003ose.2_Missense_Mutation_p.P303L	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	303	Gln-rich.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)															---	---	---	---
TRERF1	55809	broad.mit.edu	37	6	42237177	42237177	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:42237177G>A	uc003osd.2	-	5	715	c.152C>T	c.(151-153)TCG>TTG	p.S51L	TRERF1_uc011duq.1_Missense_Mutation_p.S51L|TRERF1_uc003osb.2_Intron|TRERF1_uc003osc.2_Intron|TRERF1_uc003ose.2_Missense_Mutation_p.S51L	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	51					cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)															---	---	---	---
CUL7	9820	broad.mit.edu	37	6	43018788	43018788	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:43018788C>A	uc003otq.2	-	4	1454	c.1151G>T	c.(1150-1152)CGG>CTG	p.R384L	CUL7_uc011dvb.1_Missense_Mutation_p.R468L|CUL7_uc010jyh.2_Intron|KLC4_uc003otr.1_Intron	NM_014780	NP_055595	Q14999	CUL7_HUMAN	cullin 7	384	Interaction with TP53.				interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			ovary(3)|kidney(1)	4			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)															---	---	---	---
KLC4	89953	broad.mit.edu	37	6	43034086	43034086	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:43034086A>G	uc003otv.1	+	5	691	c.614A>G	c.(613-615)TAT>TGT	p.Y205C	KLC4_uc003otr.1_RNA|KLC4_uc011dvd.1_Missense_Mutation_p.Y128C|KLC4_uc003otu.2_Missense_Mutation_p.Y205C|KLC4_uc003otw.1_Missense_Mutation_p.Y223C|KLC4_uc003otx.1_Missense_Mutation_p.Y205C|KLC4_uc003oty.1_Missense_Mutation_p.Y205C|KLC4_uc003otz.1_Missense_Mutation_p.Y205C	NM_201521	NP_958929	Q9NSK0	KLC4_HUMAN	kinesin-like 8 isoform a	205						cytoplasm|kinesin complex|microtubule	microtubule motor activity|protein binding			skin(3)|ovary(1)	4			all cancers(41;0.00169)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0376)|KIRC - Kidney renal clear cell carcinoma(2;0.0453)															---	---	---	---
ZNF318	24149	broad.mit.edu	37	6	43325431	43325431	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:43325431G>A	uc003oux.2	-	3	699	c.621C>T	c.(619-621)TCC>TCT	p.S207S	ZNF318_uc003ouw.2_RNA	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	207					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)															---	---	---	---
GPR116	221395	broad.mit.edu	37	6	46826498	46826498	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:46826498A>G	uc003oyo.3	-	17	3431	c.3142T>C	c.(3142-3144)TAT>CAT	p.Y1048H	GPR116_uc011dwj.1_Missense_Mutation_p.Y603H|GPR116_uc011dwk.1_Missense_Mutation_p.Y477H|GPR116_uc003oyp.3_Missense_Mutation_p.Y906H|GPR116_uc003oyq.3_Missense_Mutation_p.Y1048H|GPR116_uc010jzi.1_Missense_Mutation_p.Y720H	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	1048	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)															---	---	---	---
GPR115	221393	broad.mit.edu	37	6	47682692	47682692	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:47682692G>A	uc003oza.1	+	6	1969	c.1711G>A	c.(1711-1713)GCT>ACT	p.A571T	GPR115_uc003oyz.1_Missense_Mutation_p.A628T|GPR115_uc003ozb.1_Missense_Mutation_p.A569T	NM_153838	NP_722580	Q8IZF3	GP115_HUMAN	G-protein coupled receptor 115 precursor	571	Helical; Name=5; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8																		---	---	---	---
TINAG	27283	broad.mit.edu	37	6	54214656	54214656	+	Missense_Mutation	SNP	A	G	G	rs149134126		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:54214656A>G	uc003pcj.2	+	7	1188	c.1042A>G	c.(1042-1044)ATC>GTC	p.I348V	TINAG_uc010jzt.2_RNA	NM_014464	NP_055279	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	348					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity			ovary(3)|central_nervous_system(1)	4	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)															---	---	---	---
BMP5	653	broad.mit.edu	37	6	55620351	55620351	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:55620351G>A	uc003pcq.2	-	7	2057	c.1345C>T	c.(1345-1347)CGC>TGC	p.R449C	BMP5_uc011dxf.1_Missense_Mutation_p.R412C	NM_021073	NP_066551	P22003	BMP5_HUMAN	bone morphogenetic protein 5 preproprotein	449					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			ovary(2)	2	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)															---	---	---	---
DST	667	broad.mit.edu	37	6	56358915	56358915	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:56358915G>A	uc003pdf.2	-	77	13958	c.13930C>T	c.(13930-13932)CAG>TAG	p.Q4644*	DST_uc003pcz.3_Nonsense_Mutation_p.Q4466*|DST_uc011dxj.1_Nonsense_Mutation_p.Q4495*|DST_uc011dxk.1_Nonsense_Mutation_p.Q4506*|DST_uc003pcy.3_Nonsense_Mutation_p.Q4140*|DST_uc003pda.3_5'Flank	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	6552	Spectrin 16.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)															---	---	---	---
DST	667	broad.mit.edu	37	6	56362821	56362821	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:56362821A>T	uc003pdf.2	-	75	13598	c.13570T>A	c.(13570-13572)TCC>ACC	p.S4524T	DST_uc003pcz.3_Missense_Mutation_p.S4346T|DST_uc011dxj.1_Missense_Mutation_p.S4375T|DST_uc011dxk.1_Missense_Mutation_p.S4386T|DST_uc003pcy.3_Missense_Mutation_p.S4020T	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	6432	Spectrin 15.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)															---	---	---	---
ZNF451	26036	broad.mit.edu	37	6	57012429	57012429	+	Missense_Mutation	SNP	C	T	T	rs113698145		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:57012429C>T	uc003pdm.1	+	10	1770	c.1546C>T	c.(1546-1548)CAC>TAC	p.H516Y	ZNF451_uc003pdl.2_Missense_Mutation_p.H516Y|ZNF451_uc003pdn.1_Missense_Mutation_p.H516Y|uc003pdq.1_Intron|ZNF451_uc003pdk.1_Missense_Mutation_p.H516Y	NM_001031623	NP_001026794	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451 isoform 1	516	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)															---	---	---	---
PRIM2	5558	broad.mit.edu	37	6	57190736	57190736	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:57190736C>T	uc003pdx.2	+	5	439	c.352C>T	c.(352-354)CGC>TGC	p.R118C	PRIM2_uc003pdv.1_Missense_Mutation_p.R118C|PRIM2_uc003pdw.2_Missense_Mutation_p.R118C	NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	118					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)														---	---	---	---
KHDRBS2	202559	broad.mit.edu	37	6	62604724	62604724	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:62604724G>A	uc003peg.2	-	6	873	c.626C>T	c.(625-627)GCC>GTC	p.A209V		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	209					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)														---	---	---	---
COL9A1	1297	broad.mit.edu	37	6	70961812	70961812	+	Intron	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:70961812G>T	uc003pfg.3	-						COL9A1_uc003pfe.3_Intron|COL9A1_uc003pff.3_Intron	NM_001851	NP_001842			alpha 1 type IX collagen isoform 1 precursor						axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			ovary(4)	4																		---	---	---	---
FAM135A	57579	broad.mit.edu	37	6	71233735	71233735	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:71233735C>A	uc003pfj.2	+	12	1302	c.1169C>A	c.(1168-1170)CCC>CAC	p.P390H	FAM135A_uc003pfi.2_Missense_Mutation_p.P390H|FAM135A_uc003pfh.2_Missense_Mutation_p.P373H|FAM135A_uc003pfk.2_Missense_Mutation_p.P416H|FAM135A_uc003pfl.2_Missense_Mutation_p.P253H|FAM135A_uc003pfn.2_Missense_Mutation_p.P16H|FAM135A_uc003pfo.1_5'Flank	NM_001162529	NP_001156001	Q9P2D6	F135A_HUMAN	hypothetical protein LOC57579 isoform c	390										central_nervous_system(1)	1																		---	---	---	---
B3GAT2	135152	broad.mit.edu	37	6	71603902	71603902	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:71603902A>G	uc003pfv.2	-	2	1321	c.665T>C	c.(664-666)GTG>GCG	p.V222A	B3GAT2_uc011dxz.1_RNA|B3GAT2_uc003pfw.2_Missense_Mutation_p.V222A	NM_080742	NP_542780	Q9NPZ5	B3GA2_HUMAN	beta-1,3-glucuronyltransferase 2	222	Lumenal (Potential).				carbohydrate biosynthetic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|metal ion binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3																		---	---	---	---
OGFRL1	79627	broad.mit.edu	37	6	72003284	72003284	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:72003284T>C	uc003pfx.1	+	3	533	c.370T>C	c.(370-372)TAT>CAT	p.Y124H		NM_024576	NP_078852	Q5TC84	OGRL1_HUMAN	opioid growth factor receptor-like 1	124						membrane	receptor activity				0																		---	---	---	---
C6orf221	154288	broad.mit.edu	37	6	74073542	74073542	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:74073542C>A	uc003pgt.3	+	3	666	c.613C>A	c.(613-615)CGG>AGG	p.R205R		NM_001017361	NP_001017361	Q587J8	ECAT1_HUMAN	hypothetical protein LOC154288	205										skin(2)	2																		---	---	---	---
COL12A1	1303	broad.mit.edu	37	6	75799923	75799923	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:75799923T>C	uc003phs.2	-	63	9010	c.8844A>G	c.(8842-8844)GGA>GGG	p.G2948G	COL12A1_uc003pht.2_Silent_p.G1784G	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	2948	Triple-helical region (COL1) with 2 imperfections.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9																		---	---	---	---
COL12A1	1303	broad.mit.edu	37	6	75833999	75833999	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:75833999G>T	uc003phs.2	-	41	6862	c.6696C>A	c.(6694-6696)TCC>TCA	p.S2232S	COL12A1_uc003pht.2_Silent_p.S1068S	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	2232	Fibronectin type-III 18.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9																		---	---	---	---
PHIP	55023	broad.mit.edu	37	6	79675723	79675723	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:79675723C>T	uc003pir.2	-	28	3482	c.3256G>A	c.(3256-3258)GAA>AAA	p.E1086K	PHIP_uc003piq.2_Missense_Mutation_p.E110K|PHIP_uc011dyp.1_Missense_Mutation_p.E1085K|PHIP_uc003pio.3_5'UTR	NM_017934	NP_060404	Q8WWQ0	PHIP_HUMAN	pleckstrin homology domain interacting protein	1086	Mediates interaction with IRS1 (By similarity).				insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	6		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)														---	---	---	---
IBTK	25998	broad.mit.edu	37	6	82883120	82883120	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:82883120T>C	uc003pjl.1	-	27	4288	c.3761A>G	c.(3760-3762)AAC>AGC	p.N1254S	IBTK_uc011dyu.1_Missense_Mutation_p.N205S|IBTK_uc011dyv.1_Missense_Mutation_p.N1239S|IBTK_uc011dyw.1_Missense_Mutation_p.N1053S|IBTK_uc010kbi.1_Missense_Mutation_p.N948S	NM_015525	NP_056340	Q9P2D0	IBTK_HUMAN	inhibitor of Bruton's tyrosine kinase	1254					negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity			ovary(2)|central_nervous_system(2)	4		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)														---	---	---	---
IBTK	25998	broad.mit.edu	37	6	82933343	82933343	+	Intron	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:82933343A>G	uc003pjl.1	-						IBTK_uc011dyv.1_Intron|IBTK_uc011dyw.1_Intron|IBTK_uc010kbi.1_Intron|IBTK_uc003pjm.2_Intron	NM_015525	NP_056340			inhibitor of Bruton's tyrosine kinase						negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity			ovary(2)|central_nervous_system(2)	4		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)														---	---	---	---
DOPEY1	23033	broad.mit.edu	37	6	83847804	83847804	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:83847804A>G	uc003pjs.1	+	21	4303	c.4043A>G	c.(4042-4044)GAC>GGC	p.D1348G	DOPEY1_uc011dyy.1_Missense_Mutation_p.D1339G|DOPEY1_uc010kbl.1_Missense_Mutation_p.D1339G|DOPEY1_uc003pjt.2_RNA	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	1348					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)														---	---	---	---
DOPEY1	23033	broad.mit.edu	37	6	83861592	83861592	+	Intron	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:83861592A>G	uc003pjs.1	+						DOPEY1_uc011dyy.1_Intron|DOPEY1_uc010kbl.1_Intron|DOPEY1_uc003pjt.2_Intron	NM_015018	NP_055833			dopey family member 1						protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)														---	---	---	---
SNAP91	9892	broad.mit.edu	37	6	84368747	84368747	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:84368747C>A	uc011dze.1	-	6	834	c.517G>T	c.(517-519)GGA>TGA	p.G173*	SNAP91_uc003pkb.2_Nonsense_Mutation_p.G138*|SNAP91_uc003pkc.2_Nonsense_Mutation_p.G173*|SNAP91_uc003pkd.2_Nonsense_Mutation_p.G173*|SNAP91_uc003pka.2_Nonsense_Mutation_p.G173*|SNAP91_uc011dzf.1_Nonsense_Mutation_p.G54*	NM_014841	NP_055656	O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa homolog	173					clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			ovary(1)	1		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)														---	---	---	---
TBX18	9096	broad.mit.edu	37	6	85446535	85446535	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:85446535C>A	uc003pkl.1	-	8	1692	c.1692G>T	c.(1690-1692)ACG>ACT	p.T564T	TBX18_uc010kbq.1_Intron	NM_001080508	NP_001073977	O95935	TBX18_HUMAN	T-box 18	564					multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|pancreas(2)|lung(1)	5		all_cancers(76;0.000283)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0858)		BRCA - Breast invasive adenocarcinoma(108;0.0267)														---	---	---	---
ZNF292	23036	broad.mit.edu	37	6	87964552	87964552	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:87964552C>T	uc003plm.3	+	8	1246	c.1205C>T	c.(1204-1206)GCG>GTG	p.A402V		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	402					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)														---	---	---	---
ORC3L	23595	broad.mit.edu	37	6	88315636	88315636	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:88315636T>C	uc003pmh.2	+	5	368	c.324T>C	c.(322-324)GGT>GGC	p.G108G	ORC3L_uc011dzl.1_Silent_p.G108G|ORC3L_uc011dzm.1_Silent_p.G108G|ORC3L_uc011dzn.1_RNA|ORC3L_uc003pmg.2_Silent_p.G108G|ORC3L_uc003pmi.2_Silent_p.G108G|ORC3L_uc011dzo.1_5'UTR|ORC3L_uc011dzp.1_5'UTR	NM_012381	NP_036513	Q9UBD5	ORC3_HUMAN	origin recognition complex, subunit 3 isoform 2	108					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	DNA replication origin binding|protein binding				0		all_cancers(76;9.05e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;5.29e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.0469)														---	---	---	---
ANKRD6	22881	broad.mit.edu	37	6	90312801	90312801	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:90312801C>T	uc003pni.3	+	4	614	c.273C>T	c.(271-273)ATC>ATT	p.I91I	ANKRD6_uc003pne.3_Silent_p.I91I|ANKRD6_uc003pnf.3_Silent_p.I91I|ANKRD6_uc011dzy.1_Silent_p.I91I|ANKRD6_uc010kcd.2_Silent_p.I91I|LYRM2_uc010kce.1_Intron|LYRM2_uc003png.2_RNA|ANKRD6_uc003pnh.3_5'UTR	NM_014942	NP_055757	Q9Y2G4	ANKR6_HUMAN	ankyrin repeat domain 6	91	ANK 3.						protein binding			ovary(2)|pancreas(1)	3		all_cancers(76;1.22e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;1.83e-05)|Lung NSC(302;0.239)		BRCA - Breast invasive adenocarcinoma(108;0.0209)														---	---	---	---
MDN1	23195	broad.mit.edu	37	6	90380703	90380703	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:90380703T>C	uc003pnn.1	-	83	14007	c.13891A>G	c.(13891-13893)ACT>GCT	p.T4631A		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	4631					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)														---	---	---	---
MDN1	23195	broad.mit.edu	37	6	90394665	90394665	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:90394665T>C	uc003pnn.1	-	71	11875	c.11759A>G	c.(11758-11760)TAC>TGC	p.Y3920C		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	3920					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)														---	---	---	---
BACH2	60468	broad.mit.edu	37	6	90659999	90659999	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:90659999C>A	uc011eab.1	-	7	2635	c.1826G>T	c.(1825-1827)AGG>ATG	p.R609M	BACH2_uc003pnw.2_Missense_Mutation_p.R609M|BACH2_uc010kch.2_Missense_Mutation_p.R609M	NM_021813	NP_068585	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper	609						nucleus	protein dimerization activity|sequence-specific DNA binding			ovary(3)|pancreas(1)|lung(1)|skin(1)	6		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)														---	---	---	---
BACH2	60468	broad.mit.edu	37	6	90660239	90660239	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:90660239G>A	uc011eab.1	-	7	2395	c.1586C>T	c.(1585-1587)GCG>GTG	p.A529V	BACH2_uc003pnw.2_Missense_Mutation_p.A529V|BACH2_uc010kch.2_Missense_Mutation_p.A529V	NM_021813	NP_068585	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper	529						nucleus	protein dimerization activity|sequence-specific DNA binding			ovary(3)|pancreas(1)|lung(1)|skin(1)	6		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)														---	---	---	---
SFRS18	25957	broad.mit.edu	37	6	99849046	99849046	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:99849046T>A	uc003ppo.3	-	12	2016	c.1788A>T	c.(1786-1788)AGA>AGT	p.R596S	SFRS18_uc003ppl.2_Missense_Mutation_p.R142S|SFRS18_uc003ppp.3_Missense_Mutation_p.R596S|SFRS18_uc011eag.1_Missense_Mutation_p.R596S	NM_032870	NP_116259	Q8TF01	PNISR_HUMAN	splicing factor, arginine/serine-rich 130	596						nuclear speck					0		all_cancers(76;1.24e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.00716)|Colorectal(196;0.0691)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0631)														---	---	---	---
FOXO3	2309	broad.mit.edu	37	6	108984970	108984970	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:108984970C>T	uc003psk.2	+	3	1250	c.934C>T	c.(934-936)CGC>TGC	p.R312C	FOXO3_uc003psn.2_Intron|FOXO3_uc003psm.2_Missense_Mutation_p.R312C|FOXO3_uc011ean.1_Missense_Mutation_p.R92C|FOXO3_uc010kdj.1_Missense_Mutation_p.R92C	NM_201559	NP_963853	O43524	FOXO3_HUMAN	forkhead box O3A	312				PGSPTSRSSDELDAWTDFRSRTNSNASTVSGRLSPIMAS -> AWQPHVNAAVMSWMRGRTSVHAPILTPAQSVAACRPSW QV (in Ref. 5; CAA04860).	antral ovarian follicle growth|apoptosis|embryo development|glucose homeostasis|induction of apoptosis|initiation of primordial ovarian follicle growth|insulin receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|oocyte maturation|ovulation from ovarian follicle|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			central_nervous_system(4)|lung(2)	6		all_cancers(87;1.78e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;3.88e-05)|Colorectal(196;0.0294)|all_lung(197;0.0487)|Lung SC(18;0.152)		Epithelial(106;0.000759)|all cancers(137;0.00121)|BRCA - Breast invasive adenocarcinoma(108;0.00163)|OV - Ovarian serous cystadenocarcinoma(136;0.00718)														---	---	---	---
MICAL1	64780	broad.mit.edu	37	6	109771647	109771647	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:109771647T>C	uc003ptj.2	-	7	1301	c.1047A>G	c.(1045-1047)CTA>CTG	p.L349L	MICAL1_uc003ptk.2_Silent_p.L349L|MICAL1_uc010kdr.2_Intron|MICAL1_uc011eaq.1_Silent_p.L368L	NM_022765	NP_073602	Q8TDZ2	MICA1_HUMAN	microtubule associated monoxygenase, calponin	349					cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			breast(2)|ovary(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)														---	---	---	---
GPR6	2830	broad.mit.edu	37	6	110300985	110300985	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:110300985C>T	uc011eaw.1	+	2	850	c.670C>T	c.(670-672)CGC>TGC	p.R224C	GPR6_uc011eav.1_Missense_Mutation_p.R239C|GPR6_uc003ptu.2_Missense_Mutation_p.R224C	NM_005284	NP_005275	P46095	GPR6_HUMAN	G protein-coupled receptor 6	224	Extracellular (Potential).					integral to plasma membrane					0		all_cancers(87;1.64e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;2.83e-05)|all_lung(197;0.00016)|Lung NSC(302;0.000318)|Colorectal(196;0.0488)		BRCA - Breast invasive adenocarcinoma(108;8.01e-05)|Epithelial(106;8.76e-05)|all cancers(137;0.000197)|OV - Ovarian serous cystadenocarcinoma(136;0.0307)														---	---	---	---
AMD1	262	broad.mit.edu	37	6	111210137	111210137	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:111210137T>C	uc003puk.1	+	3	597	c.275T>C	c.(274-276)GTT>GCT	p.V92A	AMD1_uc011eay.1_Missense_Mutation_p.V23A|AMD1_uc011eaz.1_Missense_Mutation_p.V63A|AMD1_uc011eba.1_Intron|AMD1_uc003pul.1_Intron	NM_001634	NP_001625	P17707	DCAM_HUMAN	adenosylmethionine decarboxylase 1 isoform 1	92					spermidine biosynthetic process|spermine biosynthetic process	cytosol	adenosylmethionine decarboxylase activity			upper_aerodigestive_tract(1)	1		all_cancers(87;3.83e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0209)		OV - Ovarian serous cystadenocarcinoma(136;0.0522)|Epithelial(106;0.111)|all cancers(137;0.143)	S-Adenosylmethionine(DB00118)													---	---	---	---
ROS1	6098	broad.mit.edu	37	6	117710733	117710733	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:117710733A>G	uc003pxp.1	-	12	1738	c.1539T>C	c.(1537-1539)GAT>GAC	p.D513D	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	513	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)				T	GOPC|ROS1	glioblastoma|NSCLC								---	---	---	---
GOPC	57120	broad.mit.edu	37	6	117923425	117923425	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:117923425T>C	uc003pxu.2	-	1	257	c.27A>G	c.(25-27)GCA>GCG	p.A9A	GOPC_uc003pxv.2_Silent_p.A9A	NM_020399	NP_065132	Q9HD26	GOPC_HUMAN	golgi associated PDZ and coiled-coil motif	9					apical protein localization|cytoplasmic sequestering of CFTR protein|ER to Golgi vesicle-mediated transport|Golgi to plasma membrane transport|protein homooligomerization|protein transport	cell junction|dendrite|Golgi membrane|postsynaptic density|postsynaptic membrane|trans-Golgi network transport vesicle	cystic fibrosis transmembrane conductance regulator binding			ovary(1)	1		all_cancers(87;0.00844)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0363)|OV - Ovarian serous cystadenocarcinoma(136;0.0821)|all cancers(137;0.0976)				O	ROS1	glioblastoma						OREG0017633	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
GJA1	2697	broad.mit.edu	37	6	121768887	121768887	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:121768887C>T	uc003pyr.2	+	2	1144	c.894C>T	c.(892-894)TGC>TGT	p.C298C	GJA1_uc011ebo.1_Silent_p.C199C|GJA1_uc011ebp.1_Silent_p.C86C	NM_000165	NP_000156	P17302	CXA1_HUMAN	connexin 43	298	Cytoplasmic (Potential).				cell-cell signaling|cellular membrane organization|gap junction assembly|heart development|muscle contraction|positive regulation of I-kappaB kinase/NF-kappaB cascade	connexon complex|Golgi-associated vesicle membrane|integral to plasma membrane|membrane raft	ion transmembrane transporter activity|signal transducer activity			ovary(2)	2				GBM - Glioblastoma multiforme(226;0.00252)	Carvedilol(DB01136)													---	---	---	---
TPD52L1	7164	broad.mit.edu	37	6	125541281	125541281	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:125541281A>G	uc003pzu.1	+	2	296	c.77A>G	c.(76-78)GAC>GGC	p.D26G	TPD52L1_uc003pzv.1_Missense_Mutation_p.D26G|TPD52L1_uc003pzw.1_Missense_Mutation_p.D26G|TPD52L1_uc003pzx.1_5'UTR|TPD52L1_uc003pzy.1_5'UTR|TPD52L1_uc003pzz.1_5'UTR	NM_003287	NP_003278	Q16890	TPD53_HUMAN	tumor protein D52-like 1 isoform 1	26	Potential.				DNA fragmentation involved in apoptotic nuclear change|G2/M transition of mitotic cell cycle|induction of apoptosis|positive regulation of JNK cascade|positive regulation of MAP kinase activity	perinuclear region of cytoplasm	caspase activator activity|protein heterodimerization activity|protein homodimerization activity				0			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0265)														---	---	---	---
LAMA2	3908	broad.mit.edu	37	6	129636721	129636721	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:129636721C>T	uc003qbn.2	+	25	3761	c.3656C>T	c.(3655-3657)GCC>GTC	p.A1219V	LAMA2_uc003qbo.2_Missense_Mutation_p.A1219V	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1219	Laminin IV type A 2.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)														---	---	---	---
ARHGAP18	93663	broad.mit.edu	37	6	129959541	129959541	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:129959541T>C	uc003qbr.2	-	3	639	c.550A>G	c.(550-552)ACA>GCA	p.T184A	ARHGAP18_uc011ebw.1_Missense_Mutation_p.T184A	NM_033515	NP_277050	Q8N392	RHG18_HUMAN	Rho GTPase activating protein 18	184					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			ovary(2)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(136;0.0621)|GBM - Glioblastoma multiforme(226;0.0638)|all cancers(137;0.074)														---	---	---	---
TMEM200A	114801	broad.mit.edu	37	6	130761656	130761656	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:130761656C>A	uc003qca.2	+	3	960	c.89C>A	c.(88-90)CCG>CAG	p.P30Q	TMEM200A_uc010kfh.2_Missense_Mutation_p.P30Q|TMEM200A_uc010kfi.2_Missense_Mutation_p.P30Q|TMEM200A_uc003qcb.2_Missense_Mutation_p.P30Q	NM_052913	NP_443145	Q86VY9	T200A_HUMAN	transmembrane protein 200A	30	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)														---	---	---	---
EPB41L2	2037	broad.mit.edu	37	6	131179333	131179333	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:131179333C>T	uc003qch.2	-	19	3143	c.2961G>A	c.(2959-2961)TCG>TCA	p.S987S	EPB41L2_uc003qce.1_Silent_p.S365S|EPB41L2_uc003qcf.1_RNA|EPB41L2_uc003qcg.1_Silent_p.S729S|EPB41L2_uc011eby.1_Silent_p.S655S|EPB41L2_uc003qci.2_Silent_p.S834S|EPB41L2_uc010kfk.2_Silent_p.S655S|EPB41L2_uc003qcd.1_Silent_p.S148S	NM_001431	NP_001422	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	987	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			central_nervous_system(1)|skin(1)	2	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)														---	---	---	---
MED23	9439	broad.mit.edu	37	6	131919553	131919553	+	Silent	SNP	T	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:131919553T>G	uc003qcs.1	-	20	2655	c.2481A>C	c.(2479-2481)GCA>GCC	p.A827A	MED23_uc003qcq.2_Silent_p.A833A|MED23_uc011eca.1_Silent_p.A468A|MED23_uc003qct.1_Silent_p.A833A	NM_004830	NP_004821	Q9ULK4	MED23_HUMAN	mediator complex subunit 23 isoform a	827					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)														---	---	---	---
EYA4	2070	broad.mit.edu	37	6	133833922	133833922	+	Intron	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:133833922G>T	uc003qec.3	+						EYA4_uc011ecq.1_Intron|EYA4_uc011ecr.1_Intron|EYA4_uc003qed.3_Intron|EYA4_uc003qee.3_Intron|EYA4_uc011ecs.1_Intron|uc003qeg.1_Intron	NM_004100	NP_004091			eyes absent 4 isoform a						anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			large_intestine(2)	2	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)														---	---	---	---
TCF21	6943	broad.mit.edu	37	6	134210668	134210668	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:134210668G>A	uc003qei.3	+	1	409	c.133G>A	c.(133-135)GAG>AAG	p.E45K	uc003qeg.1_5'Flank|TCF21_uc003qej.2_Missense_Mutation_p.E45K	NM_003206	NP_003197	O43680	TCF21_HUMAN	transcription factor 21	45					branching involved in ureteric bud morphogenesis|mesoderm development|negative regulation of androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus	androgen receptor binding|E-box binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity				0	Colorectal(23;0.221)|Breast(56;0.247)			GBM - Glioblastoma multiforme(68;0.00518)|OV - Ovarian serous cystadenocarcinoma(155;0.00783)														---	---	---	---
MYB	4602	broad.mit.edu	37	6	135516107	135516107	+	Intron	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:135516107C>T	uc003qfc.2	+						MYB_uc003qfh.2_Intron|MYB_uc003qfi.2_Intron|MYB_uc010kgi.2_Intron|MYB_uc003qfq.2_Intron|MYB_uc010kgj.2_Intron|MYB_uc003qfo.2_Intron|MYB_uc003qfu.2_Intron|MYB_uc003qfl.2_Intron|MYB_uc003qfv.2_Intron|MYB_uc003qfz.2_Intron|MYB_uc003qfx.2_RNA|MYB_uc003qga.2_Intron|MYB_uc003qgb.2_Intron|MYB_uc010kgk.2_Intron|MYB_uc003qfd.2_Intron|MYB_uc003qfe.2_Intron|MYB_uc003qfg.2_RNA|MYB_uc003qff.2_Intron|MYB_uc003qfj.2_Intron|MYB_uc003qfm.2_Intron|MYB_uc003qfp.2_RNA|MYB_uc003qfn.2_Intron|MYB_uc003qfk.2_RNA|MYB_uc003qfr.2_RNA|MYB_uc003qfs.2_5'UTR|MYB_uc003qft.2_RNA|MYB_uc003qfw.2_Intron|MYB_uc003qfy.2_Intron|MYB_uc003qgc.2_RNA|MYB_uc003qfb.1_Intron|MYB_uc003qge.1_5'Flank	NM_005375	NP_005366			v-myb myeloblastosis viral oncogene homolog						blood coagulation|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone H3-K4 methylation|positive regulation of histone H3-K9 methylation|positive regulation of T-helper cell differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear matrix	DNA binding|protein binding			lung(1)	1	all_epithelial(2;0.109)|Breast(56;0.158)|Colorectal(23;0.221)	Lung NSC(302;3.08e-05)|Ovarian(999;0.208)		OV - Ovarian serous cystadenocarcinoma(155;0.0079)|GBM - Glioblastoma multiforme(68;0.0117)				T	NFIB	adenoid cystic carcinoma								---	---	---	---
MYB	4602	broad.mit.edu	37	6	135518328	135518328	+	Intron	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:135518328T>C	uc003qfc.2	+						MYB_uc003qfh.2_Missense_Mutation_p.V478A|MYB_uc003qfi.2_Missense_Mutation_p.V462A|MYB_uc010kgi.2_Intron|MYB_uc003qfq.2_Missense_Mutation_p.V475A|MYB_uc010kgj.2_Intron|MYB_uc003qfo.2_Intron|MYB_uc003qfu.2_Intron|MYB_uc003qfl.2_Intron|MYB_uc003qfv.2_Intron|MYB_uc003qfz.2_RNA|MYB_uc003qfx.2_Intron|MYB_uc003qga.2_Intron|MYB_uc003qgb.2_Intron|MYB_uc010kgk.2_Intron|MYB_uc003qfd.2_Intron|MYB_uc003qfe.2_Intron|MYB_uc003qfg.2_Intron|MYB_uc003qff.2_Intron|MYB_uc003qfj.2_Intron|MYB_uc003qfm.2_RNA|MYB_uc003qfp.2_RNA|MYB_uc003qfn.2_Intron|MYB_uc003qfk.2_Intron|MYB_uc003qfr.2_Intron|MYB_uc003qfs.2_Intron|MYB_uc003qft.2_Intron|MYB_uc003qfw.2_Intron|MYB_uc003qfy.2_RNA|MYB_uc003qgc.2_Intron|MYB_uc003qfb.1_Intron|MYB_uc003qge.1_RNA	NM_005375	NP_005366			v-myb myeloblastosis viral oncogene homolog						blood coagulation|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone H3-K4 methylation|positive regulation of histone H3-K9 methylation|positive regulation of T-helper cell differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear matrix	DNA binding|protein binding			lung(1)	1	all_epithelial(2;0.109)|Breast(56;0.158)|Colorectal(23;0.221)	Lung NSC(302;3.08e-05)|Ovarian(999;0.208)		OV - Ovarian serous cystadenocarcinoma(155;0.0079)|GBM - Glioblastoma multiforme(68;0.0117)				T	NFIB	adenoid cystic carcinoma								---	---	---	---
IFNGR1	3459	broad.mit.edu	37	6	137527263	137527263	+	Intron	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:137527263T>C	uc003qho.2	-						IFNGR1_uc011edm.1_Intron|IFNGR1_uc011edn.1_Intron	NM_000416	NP_000407			interferon gamma receptor 1 precursor						regulation of interferon-gamma-mediated signaling pathway|response to virus	integral to plasma membrane	interferon-gamma receptor activity			upper_aerodigestive_tract(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000829)|OV - Ovarian serous cystadenocarcinoma(155;0.00389)	Interferon gamma-1b(DB00033)													---	---	---	---
HIVEP2	3097	broad.mit.edu	37	6	143095619	143095619	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:143095619G>T	uc003qjd.2	-	5	1000	c.257C>A	c.(256-258)CCG>CAG	p.P86Q		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	86					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)														---	---	---	---
KATNA1	11104	broad.mit.edu	37	6	149918302	149918302	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:149918302G>A	uc003qmr.1	-	9	1219	c.1174C>T	c.(1174-1176)CGA>TGA	p.R392*	KATNA1_uc003qms.2_Nonsense_Mutation_p.R392*|KATNA1_uc003qmt.2_Intron	NM_007044	NP_008975	O75449	KTNA1_HUMAN	katanin p60 subunit A 1	392					cell division|interphase of mitotic cell cycle|mitosis	microtubule|microtubule organizing center|spindle pole	ATP binding|microtubule binding|microtubule-severing ATPase activity|protein heterodimerization activity			skin(1)	1		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;2.95e-12)|GBM - Glioblastoma multiforme(68;0.173)														---	---	---	---
PLEKHG1	57480	broad.mit.edu	37	6	151153335	151153335	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:151153335G>A	uc003qny.1	+	16	3400	c.3088G>A	c.(3088-3090)GCC>ACC	p.A1030T	PLEKHG1_uc011eel.1_Missense_Mutation_p.A1070T|PLEKHG1_uc011eem.1_Missense_Mutation_p.A1089T|PLEKHG1_uc003qnz.2_Missense_Mutation_p.A1030T	NM_001029884	NP_001025055	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G	1030					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)														---	---	---	---
TIAM2	26230	broad.mit.edu	37	6	155498051	155498051	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:155498051A>G	uc003qqb.2	+	12	3736	c.2463A>G	c.(2461-2463)GGA>GGG	p.G821G	TIAM2_uc003qqe.2_Silent_p.G821G|TIAM2_uc010kjj.2_Silent_p.G354G|TIAM2_uc003qqf.2_Silent_p.G197G|TIAM2_uc011efl.1_Silent_p.G157G|TIAM2_uc003qqg.2_Silent_p.G133G	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	821	RBD.				apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)														---	---	---	---
TIAM2	26230	broad.mit.edu	37	6	155498077	155498077	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:155498077A>G	uc003qqb.2	+	12	3762	c.2489A>G	c.(2488-2490)CAC>CGC	p.H830R	TIAM2_uc003qqe.2_Missense_Mutation_p.H830R|TIAM2_uc010kjj.2_Missense_Mutation_p.H363R|TIAM2_uc003qqf.2_Missense_Mutation_p.H206R|TIAM2_uc011efl.1_Missense_Mutation_p.H166R|TIAM2_uc003qqg.2_Missense_Mutation_p.H142R	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	830	RBD.				apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)														---	---	---	---
RSPH3	83861	broad.mit.edu	37	6	159404767	159404767	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:159404767T>C	uc003qrx.2	-	4	1035	c.845A>G	c.(844-846)GAC>GGC	p.D282G	RSPH3_uc010kju.2_Intron|RSPH3_uc003qry.1_Missense_Mutation_p.D282G	NM_031924	NP_114130	Q86UC2	RSPH3_HUMAN	radial spoke 3 homolog	282										ovary(1)|skin(1)	2		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;2.36e-16)|BRCA - Breast invasive adenocarcinoma(81;5.92e-06)														---	---	---	---
IGF2R	3482	broad.mit.edu	37	6	160461669	160461669	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:160461669G>A	uc003qta.2	+	11	1541	c.1393G>A	c.(1393-1395)GCC>ACC	p.A465T		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	465	Lumenal (Potential).|3.				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)														---	---	---	---
IGF2R	3482	broad.mit.edu	37	6	160468379	160468379	+	Intron	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:160468379T>C	uc003qta.2	+							NM_000876	NP_000867			insulin-like growth factor 2 receptor precursor						receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)														---	---	---	---
SLC22A2	6582	broad.mit.edu	37	6	160679379	160679379	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:160679379G>T	uc003qtf.2	-	1	581	c.411C>A	c.(409-411)ACC>ACA	p.T137T	SLC22A2_uc003qte.1_Silent_p.T137T|SLC22A2_uc003qth.1_Silent_p.T137T	NM_003058	NP_003049	O15244	S22A2_HUMAN	solute carrier family 22 member 2	137	Extracellular (Potential).				body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity			breast(1)|skin(1)	2		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)														---	---	---	---
T	6862	broad.mit.edu	37	6	166571837	166571837	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:166571837G>A	uc003quu.1	-	9	1767	c.1274C>T	c.(1273-1275)GCC>GTC	p.A425V	T_uc003qut.1_Missense_Mutation_p.A426V|T_uc003quv.1_Missense_Mutation_p.A367V	NM_003181	NP_003172	O15178	BRAC_HUMAN	transcription factor T	425					anterior/posterior axis specification, embryo|mesoderm development|primitive streak formation	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2		Prostate(117;4.48e-07)|Ovarian(120;1.78e-06)|Breast(66;2.54e-06)|Lung SC(201;0.0225)|Esophageal squamous(34;0.0559)		OV - Ovarian serous cystadenocarcinoma(33;1.09e-113)|GBM - Glioblastoma multiforme(31;1.51e-108)|BRCA - Breast invasive adenocarcinoma(81;8.45e-09)|LUAD - Lung adenocarcinoma(999;0.0407)										Chordoma_Familial_Clustering_of				---	---	---	---
MLLT4	4301	broad.mit.edu	37	6	168271129	168271129	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:168271129G>A	uc003qwd.2	+	3	507	c.365G>A	c.(364-366)CGG>CAG	p.R122Q	MLLT4_uc003qwb.1_Missense_Mutation_p.R122Q|MLLT4_uc003qwc.1_Missense_Mutation_p.R122Q	NM_001040001	NP_001035090	P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	122	Ras-associating 1.				adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			ovary(2)|lung(1)|kidney(1)|central_nervous_system(1)	5		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)				T	MLL	AL								---	---	---	---
HEATR2	54919	broad.mit.edu	37	7	796443	796443	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:796443G>T	uc010krz.1	+	6	1302	c.1282G>T	c.(1282-1284)GGG>TGG	p.G428W	HEATR2_uc003siz.2_Missense_Mutation_p.G296W	NM_017802	NP_060272	Q86Y56	HEAT2_HUMAN	HEAT repeat containing 2	428							protein binding			skin(1)	1		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0182)|Epithelial(4;5.48e-17)|OV - Ovarian serous cystadenocarcinoma(56;1.95e-16)|all cancers(6;2.98e-14)														---	---	---	---
HEATR2	54919	broad.mit.edu	37	7	808793	808793	+	Intron	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:808793C>T	uc010krz.1	+						HEATR2_uc003siz.2_Intron|HEATR2_uc003sja.2_Intron|HEATR2_uc003sjb.2_Intron|HEATR2_uc003sjc.2_Silent_p.G3G	NM_017802	NP_060272			HEAT repeat containing 2								protein binding			skin(1)	1		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0182)|Epithelial(4;5.48e-17)|OV - Ovarian serous cystadenocarcinoma(56;1.95e-16)|all cancers(6;2.98e-14)														---	---	---	---
MAD1L1	8379	broad.mit.edu	37	7	2108876	2108876	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:2108876C>T	uc003slh.1	-	12	1437	c.1171G>A	c.(1171-1173)GAG>AAG	p.E391K	MAD1L1_uc003sle.1_Missense_Mutation_p.E120K|MAD1L1_uc003slf.1_Missense_Mutation_p.E391K|MAD1L1_uc003slg.1_Missense_Mutation_p.E391K|MAD1L1_uc010ksh.1_Missense_Mutation_p.E391K|MAD1L1_uc003sli.1_Missense_Mutation_p.E299K|MAD1L1_uc010ksi.1_Missense_Mutation_p.E344K|MAD1L1_uc010ksj.2_Missense_Mutation_p.E391K	NM_001013836	NP_001013858	Q9Y6D9	MD1L1_HUMAN	MAD1-like 1 protein	391	Necessary for interaction with NEK2.|Potential.				cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)														---	---	---	---
FTSJ2	29960	broad.mit.edu	37	7	2279284	2279284	+	Missense_Mutation	SNP	G	A	A	rs138187457	byFrequency	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:2279284G>A	uc003slm.2	-	2	96	c.67C>T	c.(67-69)CGC>TGC	p.R23C	FTSJ2_uc003slk.2_5'UTR|FTSJ2_uc003sll.2_5'UTR|FTSJ2_uc003sln.2_RNA|FTSJ2_uc003slo.2_5'UTR|NUDT1_uc003slp.1_5'Flank|NUDT1_uc003slq.1_5'Flank|NUDT1_uc003slr.1_5'Flank|NUDT1_uc003sls.1_5'Flank|NUDT1_uc003slt.1_5'Flank	NM_013393	NP_037525	Q9UI43	RRMJ2_HUMAN	FtsJ homolog 2	23					cell proliferation	mitochondrion|nucleolus	nucleic acid binding|rRNA (uridine-2'-O-)-methyltransferase activity			ovary(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0822)|OV - Ovarian serous cystadenocarcinoma(56;2.7e-14)														---	---	---	---
SNX8	29886	broad.mit.edu	37	7	2297420	2297420	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:2297420C>T	uc003slw.2	-	8	977	c.934G>A	c.(934-936)GAC>AAC	p.D312N		NM_013321	NP_037453	Q9Y5X2	SNX8_HUMAN	sorting nexin 8	312					cell communication|early endosome to Golgi transport|intracellular protein transport	early endosome membrane	phosphatidylinositol binding|protein binding			large_intestine(1)|ovary(1)	2		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0853)|OV - Ovarian serous cystadenocarcinoma(56;3.79e-14)														---	---	---	---
C7orf27	221927	broad.mit.edu	37	7	2577902	2577902	+	Missense_Mutation	SNP	C	A	A	rs35955968		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:2577902C>A	uc003smi.2	-	14	2309	c.2267G>T	c.(2266-2268)CGG>CTG	p.R756L	C7orf27_uc003smh.3_Missense_Mutation_p.R188L	NM_152743	NP_689956	Q6PJG6	BRAT1_HUMAN	hypothetical protein LOC221927 precursor	756					response to ionizing radiation	nucleus	protein binding				0		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;2.91e-14)														---	---	---	---
C7orf27	221927	broad.mit.edu	37	7	2583343	2583343	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:2583343G>A	uc003smi.2	-	5	726	c.684C>T	c.(682-684)TGC>TGT	p.C228C	C7orf27_uc003smh.3_5'Flank|C7orf27_uc003smj.1_Silent_p.C228C	NM_152743	NP_689956	Q6PJG6	BRAT1_HUMAN	hypothetical protein LOC221927 precursor	228					response to ionizing radiation	nucleus	protein binding				0		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;2.91e-14)														---	---	---	---
CARD11	84433	broad.mit.edu	37	7	2974156	2974156	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:2974156T>C	uc003smv.2	-	10	1853	c.1449A>G	c.(1447-1449)TCA>TCG	p.S483S		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	483					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)				Mis		DLBCL								---	---	---	---
CARD11	84433	broad.mit.edu	37	7	2984023	2984023	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:2984023C>T	uc003smv.2	-	5	911	c.507G>A	c.(505-507)ACG>ACA	p.T169T		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	169	Potential.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)				Mis		DLBCL								---	---	---	---
RNF216	54476	broad.mit.edu	37	7	5662491	5662491	+	Nonstop_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:5662491T>C	uc003soy.1	-	17	2791	c.2601A>G	c.(2599-2601)TGA>TGG	p.*867W	RNF216_uc010ksz.1_Nonstop_Mutation_p.*489W|RNF216_uc010kta.1_Nonstop_Mutation_p.*489W|RNF216_uc011jwj.1_Nonstop_Mutation_p.*489W|RNF216_uc003sox.1_Nonstop_Mutation_p.*924W	NM_207116	NP_996999	Q9NWF9	RN216_HUMAN	ring finger protein 216 isoform b	867					apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus|nucleus	ligase activity|protein binding|protein binding|zinc ion binding			ovary(3)|breast(2)	5		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)														---	---	---	---
C7orf26	79034	broad.mit.edu	37	7	6634210	6634210	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:6634210G>A	uc003sqo.1	+	3	559	c.559G>A	c.(559-561)GCG>ACG	p.A187T	C7orf26_uc003sqp.1_Missense_Mutation_p.A168T|C7orf26_uc003sqq.1_Intron	NM_024067	NP_076972	Q96N11	CG026_HUMAN	hypothetical protein LOC79034	187										ovary(1)	1		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)														---	---	---	---
HDAC9	9734	broad.mit.edu	37	7	18767320	18767320	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:18767320G>A	uc003suh.2	+	12	1881	c.1840G>A	c.(1840-1842)GCT>ACT	p.A614T	HDAC9_uc003sue.2_Missense_Mutation_p.A614T|HDAC9_uc011jyd.1_Missense_Mutation_p.A614T|HDAC9_uc003sui.2_Missense_Mutation_p.A617T|HDAC9_uc003suj.2_Missense_Mutation_p.A573T|HDAC9_uc003sua.1_Missense_Mutation_p.A592T|HDAC9_uc010kue.1_Missense_Mutation_p.A269T	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	614					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)													---	---	---	---
TMEM196	256130	broad.mit.edu	37	7	19765163	19765163	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:19765163G>C	uc011jyg.1	-	3	518	c.433C>G	c.(433-435)CAT>GAT	p.H145D	TMEM196_uc003sur.2_RNA	NM_152774	NP_689987	Q5HYL7	TM196_HUMAN	transmembrane protein 196	151						integral to membrane					0																		---	---	---	---
NFE2L3	9603	broad.mit.edu	37	7	26217597	26217597	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:26217597T>C	uc003sxq.2	+	2	877	c.605T>C	c.(604-606)GTG>GCG	p.V202A		NM_004289	NP_004280	Q9Y4A8	NF2L3_HUMAN	nuclear factor erythroid 2-like 3	202					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			skin(3)|ovary(1)	4																		---	---	---	---
HOXA3	3200	broad.mit.edu	37	7	27150193	27150193	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:27150193C>T	uc011jzl.1	-	2	267	c.67G>A	c.(67-69)GGG>AGG	p.G23R	HOXA3_uc011jzk.1_Intron|HOXA3_uc003syk.2_Missense_Mutation_p.G23R	NM_030661	NP_109377	O43365	HXA3_HUMAN	homeobox A3 isoform a	23					angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)	2																		---	---	---	---
HOXA6	3203	broad.mit.edu	37	7	27185286	27185286	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:27185286C>A	uc003syo.1	-	2	693	c.693G>T	c.(691-693)GCG>GCT	p.A231A	HOXA5_uc003syn.1_5'Flank|uc003syp.1_5'Flank	NM_024014	NP_076919	P31267	HXA6_HUMAN	homeobox A6	231						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
HOXA7	3204	broad.mit.edu	37	7	27194826	27194826	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:27194826C>A	uc003sys.2	-	2	527	c.395G>T	c.(394-396)CGG>CTG	p.R132L	HOXA6_uc003syq.1_5'Flank|uc003syr.1_3'UTR	NM_006896	NP_008827	P31268	HXA7_HUMAN	homeobox A7	132	Homeobox.				angiogenesis|negative regulation of cell-matrix adhesion|negative regulation of keratinocyte differentiation|negative regulation of leukocyte migration|negative regulation of monocyte differentiation|negative regulation of transcription from RNA polymerase II promoter		sequence-specific DNA binding|transcription factor binding				0																		---	---	---	---
FAM188B	84182	broad.mit.edu	37	7	30911931	30911931	+	Intron	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:30911931C>T	uc003tbt.2	+						FAM188B_uc010kwe.2_Intron|AQP1_uc011kac.1_Intron|FAM188B_uc003tbu.2_Intron	NM_032222	NP_115598			hypothetical protein LOC84182												0																		---	---	---	---
DPY19L1	23333	broad.mit.edu	37	7	35009088	35009088	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:35009088A>G	uc003tem.3	-	9	897	c.752T>C	c.(751-753)TTC>TCC	p.F251S		NM_015283	NP_056098	Q2PZI1	D19L1_HUMAN	dpy-19-like 1	251	Helical; (Potential).					integral to membrane					0																		---	---	---	---
POU6F2	11281	broad.mit.edu	37	7	39472696	39472696	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:39472696G>A	uc003thb.1	+	7	1089	c.1047G>A	c.(1045-1047)CTG>CTA	p.L349L		NM_007252	NP_009183	P78424	PO6F2_HUMAN	POU class 6 homeobox 2 isoform 1	349	Gln-rich.				central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1																		---	---	---	---
C7orf10	79783	broad.mit.edu	37	7	40900065	40900065	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:40900065A>C	uc003thn.1	+	14	1349	c.1304A>C	c.(1303-1305)CAT>CCT	p.H435P	C7orf10_uc003thm.1_Missense_Mutation_p.H431P|C7orf10_uc003tho.1_Missense_Mutation_p.H387P|C7orf10_uc003thp.1_RNA	NM_024728	NP_079004	Q9HAC7	CG010_HUMAN	dermal papilla derived protein 13	442							transferase activity			ovary(2)	2																		---	---	---	---
GLI3	2737	broad.mit.edu	37	7	42005281	42005281	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:42005281G>A	uc011kbh.1	-	15	3481	c.3390C>T	c.(3388-3390)GAC>GAT	p.D1130D	GLI3_uc011kbg.1_Silent_p.D1071D	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1130					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19														Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				---	---	---	---
POLM	27434	broad.mit.edu	37	7	44118330	44118330	+	Intron	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:44118330C>A	uc003tjt.2	-						POLM_uc003tjw.1_5'Flank|POLM_uc003tju.2_Intron|POLM_uc003tjx.2_Intron|POLM_uc003tjv.2_Intron|POLM_uc011kbt.1_Intron|POLM_uc003tka.1_5'Flank|POLM_uc003tjz.3_Intron|POLM_uc011kbu.1_Missense_Mutation_p.R208S|POLM_uc010kxy.2_Missense_Mutation_p.R241S	NM_013284	NP_037416			DNA-directed DNA polymerase mu						DNA recombination|DNA repair	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			ovary(2)|central_nervous_system(1)	3													DNA_polymerases_(catalytic_subunits)					---	---	---	---
NPC1L1	29881	broad.mit.edu	37	7	44579719	44579719	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:44579719C>T	uc003tlb.2	-	2	333	c.277G>A	c.(277-279)GCC>ACC	p.A93T	NPC1L1_uc003tlc.2_Missense_Mutation_p.A93T|NPC1L1_uc011kbw.1_Missense_Mutation_p.A93T|NPC1L1_uc003tld.2_Missense_Mutation_p.A93T	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	93	Extracellular (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)													---	---	---	---
TBRG4	9238	broad.mit.edu	37	7	45148709	45148709	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:45148709G>A	uc003tmv.2	-	2	254	c.128C>T	c.(127-129)GCC>GTC	p.A43V	TBRG4_uc003tmu.2_5'Flank|TBRG4_uc003tmw.2_Missense_Mutation_p.A43V|TBRG4_uc003tmx.2_Missense_Mutation_p.A43V|TBRG4_uc011kcd.1_Missense_Mutation_p.A54V	NM_004749	NP_004740	Q969Z0	TBRG4_HUMAN	cell cycle progression 2 protein isoform 1	43					apoptosis|cell cycle arrest|cellular respiration|G1 phase of mitotic cell cycle|positive regulation of cell proliferation	mitochondrion	ATP binding|protein binding|protein kinase activity				0																		---	---	---	---
PKD1L1	168507	broad.mit.edu	37	7	47851503	47851503	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:47851503G>A	uc003tny.1	-	50	7493	c.7493C>T	c.(7492-7494)ACG>ATG	p.T2498M	C7orf69_uc003tnz.3_Intron|C7orf69_uc003toa.1_Intron|PKD1L1_uc003tob.2_Missense_Mutation_p.T225M	NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	2498	Extracellular (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11																		---	---	---	---
PKD1L1	168507	broad.mit.edu	37	7	47942044	47942044	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:47942044G>A	uc003tny.1	-	13	1996	c.1996C>T	c.(1996-1998)CAA>TAA	p.Q666*		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	666	Extracellular (Potential).|PKD 2.				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11																		---	---	---	---
ZNF107	51427	broad.mit.edu	37	7	64167799	64167799	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:64167799G>A	uc003ttd.2	+	7	1903	c.1117G>A	c.(1117-1119)GAA>AAA	p.E373K	ZNF107_uc003tte.2_Missense_Mutation_p.E373K	NM_016220	NP_057304	Q9UII5	ZN107_HUMAN	zinc finger protein 107	373	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.00948)|all_lung(88;0.0249)																---	---	---	---
ZNF107	51427	broad.mit.edu	37	7	64168521	64168521	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:64168521T>C	uc003ttd.2	+	7	2625	c.1839T>C	c.(1837-1839)TGT>TGC	p.C613C	ZNF107_uc003tte.2_Silent_p.C613C	NM_016220	NP_057304	Q9UII5	ZN107_HUMAN	zinc finger protein 107	613	C2H2-type 20.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.00948)|all_lung(88;0.0249)																---	---	---	---
BAZ1B	9031	broad.mit.edu	37	7	72892140	72892140	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:72892140G>A	uc003tyc.2	-	7	1996	c.1651C>T	c.(1651-1653)CGG>TGG	p.R551W		NM_032408	NP_115784	Q9UIG0	BAZ1B_HUMAN	bromodomain adjacent to zinc finger domain, 1B	551	Potential.|Lys-rich.				ATP-dependent chromatin remodeling|chromatin-mediated maintenance of transcription|DNA replication-dependent nucleosome disassembly|double-strand break repair|heart morphogenesis|transcription, DNA-dependent	WINAC complex	ATP binding|chromatin binding|histone acetyl-lysine binding|histone kinase activity|non-membrane spanning protein tyrosine kinase activity|protein complex scaffold|vitamin D receptor activator activity|vitamin D receptor binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	7		Lung NSC(55;0.0659)|all_lung(88;0.152)																---	---	---	---
MLXIPL	51085	broad.mit.edu	37	7	73038576	73038576	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:73038576C>T	uc003tyn.1	-	1	295	c.247G>A	c.(247-249)GAC>AAC	p.D83N	MLXIPL_uc003tyk.1_Missense_Mutation_p.D83N|MLXIPL_uc003tyl.1_Missense_Mutation_p.D83N|MLXIPL_uc003tym.1_Missense_Mutation_p.D83N|MLXIPL_uc003tyo.1_RNA|MLXIPL_uc003typ.1_Missense_Mutation_p.D83N	NM_032951	NP_116569	Q9NP71	WBS14_HUMAN	Williams Beuren syndrome chromosome region 14	83					anatomical structure morphogenesis|energy reserve metabolic process|glucose mediated signaling pathway|intracellular protein kinase cascade|negative regulation of cell cycle arrest|negative regulation of oxidative phosphorylation|negative regulation of peptidyl-serine phosphorylation|positive regulation of cell proliferation|positive regulation of fatty acid biosynthetic process|positive regulation of glycolysis|positive regulation of transcription from RNA polymerase II promoter|triglyceride homeostasis	cytosol|transcription factor complex	carbohydrate response element binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			pancreas(1)	1		Lung NSC(55;0.0659)|all_lung(88;0.152)																---	---	---	---
SEMA3E	9723	broad.mit.edu	37	7	83277761	83277761	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:83277761A>G	uc003uhy.1	-	1	564	c.98T>C	c.(97-99)TTA>TCA	p.L33S		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	33	Sema.				axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)																---	---	---	---
ABCB1	5243	broad.mit.edu	37	7	87183250	87183250	+	Splice_Site	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:87183250T>C	uc003uiz.1	-	10	1246	c.828_splice	c.e10-1	p.R276_splice	ABCB1_uc011khc.1_Splice_Site_p.R212_splice	NM_000927	NP_000918			ATP-binding cassette, subfamily B, member 1						G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)													---	---	---	---
C7orf63	79846	broad.mit.edu	37	7	89936277	89936277	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:89936277T>C	uc010lep.2	+	20	2579	c.2328T>C	c.(2326-2328)ACT>ACC	p.T776T	C7orf63_uc011khj.1_Silent_p.T758T|C7orf63_uc011khk.1_Silent_p.T292T	NM_001039706	NP_001034795	A5D8W1	CG063_HUMAN	hypothetical protein LOC79846 isoform 1	776							binding			ovary(1)	1																		---	---	---	---
CDK14	5218	broad.mit.edu	37	7	90747392	90747392	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:90747392T>G	uc003uky.2	+	14	1529	c.1307T>G	c.(1306-1308)TTT>TGT	p.F436C	CDK14_uc003ukz.1_Missense_Mutation_p.F418C|CDK14_uc010les.1_Missense_Mutation_p.F390C|CDK14_uc011khl.1_Missense_Mutation_p.F307C	NM_012395	NP_036527	O94921	CDK14_HUMAN	PFTAIRE protein kinase 1	436					cell division|G2/M transition of mitotic cell cycle|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane	ATP binding|cyclin binding|cyclin-dependent protein kinase activity			lung(3)|ovary(1)	4																		---	---	---	---
AKAP9	10142	broad.mit.edu	37	7	91645473	91645473	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:91645473A>G	uc003ulg.2	+	11	3868	c.3643A>G	c.(3643-3645)ACT>GCT	p.T1215A	AKAP9_uc003ule.2_Missense_Mutation_p.T1227A|AKAP9_uc003ulf.2_Missense_Mutation_p.T1215A|AKAP9_uc003uli.2_Missense_Mutation_p.T840A	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	1227					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)					T	BRAF	papillary thyroid								---	---	---	---
SAMD9	54809	broad.mit.edu	37	7	92734173	92734173	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:92734173T>C	uc003umf.2	-	3	1494	c.1238A>G	c.(1237-1239)TAC>TGC	p.Y413C	SAMD9_uc003umg.2_Missense_Mutation_p.Y413C	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	413						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)															---	---	---	---
SAMD9L	219285	broad.mit.edu	37	7	92761679	92761679	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:92761679T>C	uc003umh.1	-	5	4822	c.3606A>G	c.(3604-3606)GAA>GAG	p.E1202E	SAMD9L_uc003umj.1_Silent_p.E1202E|SAMD9L_uc003umi.1_Silent_p.E1202E|SAMD9L_uc010lfb.1_Silent_p.E1202E|SAMD9L_uc003umk.1_Silent_p.E1202E|SAMD9L_uc010lfc.1_Silent_p.E1202E|SAMD9L_uc010lfd.1_Silent_p.E1202E|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1202										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)															---	---	---	---
PPP1R9A	55607	broad.mit.edu	37	7	94750077	94750077	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:94750077G>A	uc003unp.2	+	4	1864	c.1582G>A	c.(1582-1584)GGA>AGA	p.G528R	PPP1R9A_uc010lfj.2_Missense_Mutation_p.G528R|PPP1R9A_uc011kif.1_Missense_Mutation_p.G528R|PPP1R9A_uc003unq.2_Missense_Mutation_p.G528R|PPP1R9A_uc011kig.1_Missense_Mutation_p.G528R	NM_017650	NP_060120	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	528	PDZ.					cell junction|synapse|synaptosome	actin binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)												HNSCC(28;0.073)			---	---	---	---
DYNC1I1	1780	broad.mit.edu	37	7	95726809	95726809	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:95726809C>T	uc003uoc.3	+	17	2119	c.1842C>T	c.(1840-1842)CAC>CAT	p.H614H	DYNC1I1_uc003uod.3_Silent_p.H597H|DYNC1I1_uc003uob.2_Silent_p.H577H|DYNC1I1_uc003uoe.3_Silent_p.H594H|DYNC1I1_uc010lfl.2_Silent_p.H603H	NM_004411	NP_004402	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1	614	WD 7.				vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity			ovary(3)|kidney(1)	4	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)															---	---	---	---
ASNS	440	broad.mit.edu	37	7	97493592	97493592	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:97493592C>T	uc003uot.3	-	4	972	c.466G>A	c.(466-468)GCT>ACT	p.A156T	ASNS_uc011kin.1_Missense_Mutation_p.A73T|ASNS_uc003uou.3_Missense_Mutation_p.A156T|ASNS_uc003uov.3_Missense_Mutation_p.A156T|ASNS_uc011kio.1_Missense_Mutation_p.A135T|ASNS_uc003uow.3_Missense_Mutation_p.A135T|ASNS_uc003uox.3_Missense_Mutation_p.A73T	NM_133436	NP_597680	P08243	ASNS_HUMAN	asparagine synthetase	156	Glutamine amidotransferase type-2.				cellular response to glucose starvation|glutamine metabolic process|negative regulation of apoptosis|positive regulation of mitotic cell cycle	cytosol|soluble fraction	asparagine synthase (glutamine-hydrolyzing) activity|ATP binding			ovary(1)	1	all_cancers(62;6.64e-09)|all_epithelial(64;1.58e-09)|Esophageal squamous(72;0.00448)|Lung NSC(181;0.0342)|all_lung(186;0.0369)				Adenosine triphosphate(DB00171)|L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)													---	---	---	---
BAIAP2L1	55971	broad.mit.edu	37	7	97944915	97944915	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:97944915T>C	uc003upj.2	-	7	759	c.496A>G	c.(496-498)ACC>GCC	p.T166A		NM_018842	NP_061330	Q9UHR4	BI2L1_HUMAN	BAI1-associated protein 2-like 1	166	IMD.				filopodium assembly|positive regulation of actin cytoskeleton reorganization|positive regulation of actin filament polymerization|response to bacterium|signal transduction	cell junction|cytoskeleton|cytosol|nucleus	actin binding|cytoskeletal adaptor activity|proline-rich region binding|SH3 domain binding			ovary(1)	1	all_cancers(62;4.34e-10)|all_epithelial(64;5e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0113)|all_lung(186;0.0126)		STAD - Stomach adenocarcinoma(171;0.215)															---	---	---	---
TRRAP	8295	broad.mit.edu	37	7	98533290	98533290	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:98533290C>T	uc003upp.2	+	28	4312	c.4103C>T	c.(4102-4104)GCG>GTG	p.A1368V	TRRAP_uc011kis.1_Missense_Mutation_p.A1368V|TRRAP_uc003upr.2_Missense_Mutation_p.A1060V	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	1368					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)															---	---	---	---
TRRAP	8295	broad.mit.edu	37	7	98608823	98608823	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:98608823C>T	uc003upp.2	+	70	11254	c.11045C>T	c.(11044-11046)GCG>GTG	p.A3682V	TRRAP_uc011kis.1_Missense_Mutation_p.A3653V|TRRAP_uc003upr.2_Missense_Mutation_p.A3388V|TRRAP_uc003ups.2_5'Flank	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	3682	PI3K/PI4K.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)															---	---	---	---
ZNF655	79027	broad.mit.edu	37	7	99170016	99170016	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99170016A>T	uc003urh.2	+	3	678	c.285A>T	c.(283-285)AGA>AGT	p.R95S	ZNF655_uc010lga.2_Missense_Mutation_p.R130S|ZNF655_uc010lgc.2_Missense_Mutation_p.R130S|ZNF655_uc003urj.2_Missense_Mutation_p.R95S|ZNF655_uc003urk.2_5'UTR|ZNF655_uc010lgd.2_5'UTR	NM_138494	NP_612503	Q8N720	ZN655_HUMAN	zinc finger protein 655 isoform a	95					G1 phase|regulation of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			ovary(1)	1	all_epithelial(64;3.19e-09)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)																	---	---	---	---
GIGYF1	64599	broad.mit.edu	37	7	100280207	100280207	+	Intron	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100280207G>A	uc003uwg.1	-							NM_022574	NP_072096			PERQ amino acid rich, with GYF domain 1											large_intestine(1)|central_nervous_system(1)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)																	---	---	---	---
MUC17	140453	broad.mit.edu	37	7	100681299	100681299	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100681299C>G	uc003uxp.1	+	3	6655	c.6602C>G	c.(6601-6603)TCT>TGT	p.S2201C	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2201	Extracellular (Potential).|35.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)																	---	---	---	---
PMPCB	9512	broad.mit.edu	37	7	102940681	102940681	+	Silent	SNP	T	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:102940681T>G	uc003vbl.2	+	4	418	c.384T>G	c.(382-384)GCT>GCG	p.A128A	PMPCB_uc010liu.1_Silent_p.A128A|PMPCB_uc003vbk.1_Silent_p.A128A|PMPCB_uc003vbm.2_Silent_p.A37A|PMPCB_uc010liv.2_Silent_p.A34A|PMPCB_uc010liw.2_Silent_p.A37A|PMPCB_uc011kll.1_Silent_p.A23A|PMPCB_uc011klm.1_Silent_p.A3A	NM_004279	NP_004270	O75439	MPPB_HUMAN	mitochondrial processing peptidase beta subunit	128					proteolysis	mitochondrial matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)	4																		---	---	---	---
SLC26A5	375611	broad.mit.edu	37	7	103030877	103030877	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:103030877T>C	uc003vbz.2	-	12	1546	c.1310A>G	c.(1309-1311)CAG>CGG	p.Q437R	SLC26A5_uc003vbt.1_Missense_Mutation_p.Q437R|SLC26A5_uc003vbu.1_Missense_Mutation_p.Q437R|SLC26A5_uc003vbv.1_Intron|SLC26A5_uc003vbw.2_RNA|SLC26A5_uc003vbx.2_Missense_Mutation_p.Q437R|SLC26A5_uc003vby.2_RNA|SLC26A5_uc010liy.2_Intron	NM_198999	NP_945350	P58743	S26A5_HUMAN	prestin isoform a	437	Cytoplasmic (Potential).				regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			ovary(1)	1																		---	---	---	---
SLC26A5	375611	broad.mit.edu	37	7	103050937	103050937	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:103050937G>A	uc003vbz.2	-	7	866	c.630C>T	c.(628-630)GTC>GTT	p.V210V	SLC26A5_uc003vbt.1_Silent_p.V210V|SLC26A5_uc003vbu.1_Silent_p.V210V|SLC26A5_uc003vbv.1_Silent_p.V210V|SLC26A5_uc003vbw.2_RNA|SLC26A5_uc003vbx.2_Silent_p.V210V|SLC26A5_uc003vby.2_RNA|SLC26A5_uc010liy.2_RNA	NM_198999	NP_945350	P58743	S26A5_HUMAN	prestin isoform a	210	Cytoplasmic (Potential).				regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			ovary(1)	1																		---	---	---	---
MLL5	55904	broad.mit.edu	37	7	104753406	104753406	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:104753406T>C	uc003vcm.2	+	27	5737	c.5203T>C	c.(5203-5205)TCA>CCA	p.S1735P	MLL5_uc010ljc.2_Missense_Mutation_p.S1735P|MLL5_uc010ljf.1_Intron|MLL5_uc010ljg.2_Missense_Mutation_p.S469P	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	1735	Pro-rich.				cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3																		---	---	---	---
MLL5	55904	broad.mit.edu	37	7	104753622	104753622	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:104753622A>G	uc003vcm.2	+	27	5953	c.5419A>G	c.(5419-5421)ACT>GCT	p.T1807A	MLL5_uc010ljc.2_Missense_Mutation_p.T1807A|MLL5_uc010ljf.1_RNA|MLL5_uc010ljg.2_Missense_Mutation_p.T541A	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	1807	Pro-rich.				cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3																		---	---	---	---
RINT1	60561	broad.mit.edu	37	7	105205915	105205915	+	Intron	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:105205915A>G	uc003vda.1	+						RINT1_uc010ljj.1_Intron|EFCAB10_uc003vdb.2_Intron|uc003vdd.1_5'Flank	NM_021930	NP_068749			RAD50 interactor 1						cell cycle|G2/M transition DNA damage checkpoint|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane	protein binding			ovary(3)|central_nervous_system(1)	4																		---	---	---	---
PNPLA8	50640	broad.mit.edu	37	7	108155211	108155211	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:108155211T>C	uc003vff.1	-	4	1132	c.725A>G	c.(724-726)GAA>GGA	p.E242G	PNPLA8_uc003vfg.1_RNA|PNPLA8_uc003vfh.1_Missense_Mutation_p.E242G|PNPLA8_uc003vfi.1_Missense_Mutation_p.E142G|PNPLA8_uc003vfj.1_Missense_Mutation_p.E242G|PNPLA8_uc003vfk.1_Missense_Mutation_p.E142G	NM_015723	NP_056538	Q9NP80	PLPL8_HUMAN	patatin-like phospholipase domain containing 8	242					fatty acid metabolic process|lipid catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|membrane fraction|perinuclear region of cytoplasm|peroxisomal membrane	ATP binding|calcium-independent phospholipase A2 activity|lysophospholipase activity			breast(2)	2																		---	---	---	---
FOXP2	93986	broad.mit.edu	37	7	114268597	114268597	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:114268597G>A	uc003vhb.2	+	4	635	c.261G>A	c.(259-261)GTG>GTA	p.V87V	FOXP2_uc003vgu.2_RNA|FOXP2_uc003vgz.2_Silent_p.V112V|FOXP2_uc003vha.2_5'UTR|FOXP2_uc011kmu.1_Silent_p.V87V|FOXP2_uc011kmv.1_Silent_p.V87V|FOXP2_uc010ljz.1_5'UTR|FOXP2_uc003vgt.1_RNA|FOXP2_uc003vgv.1_Silent_p.V87V|FOXP2_uc003vgw.2_Silent_p.V112V|FOXP2_uc003vgx.2_Silent_p.V87V|FOXP2_uc003vhd.2_Silent_p.V87V|FOXP2_uc003vhc.2_Silent_p.V112V	NM_014491	NP_055306	O15409	FOXP2_HUMAN	forkhead box P2 isoform I	87	Gln-rich.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|lung(1)|breast(1)|skin(1)	8																		---	---	---	---
ST7	7982	broad.mit.edu	37	7	116770650	116770650	+	Silent	SNP	C	A	A	rs144973249		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:116770650C>A	uc003vin.2	+	5	769	c.555C>A	c.(553-555)CCC>CCA	p.P185P	ST7_uc011knl.1_Silent_p.P185P|ST7_uc003vio.2_Silent_p.P185P|ST7_uc003viq.2_Silent_p.P139P|ST7_uc011knm.1_Silent_p.P142P|ST7_uc003vir.2_Silent_p.P133P|ST7OT2_uc003viu.2_Intron|ST7_uc011knn.1_Silent_p.P133P|ST7OT2_uc003viw.2_RNA|ST7_uc003vix.1_Silent_p.P21P	NM_021908	NP_068708	Q9NRC1	ST7_HUMAN	suppression of tumorigenicity 7 isoform b	185						integral to membrane	binding			central_nervous_system(1)|skin(1)	2	all_cancers(3;3.88e-07)|all_epithelial(6;3.42e-07)|Lung NSC(10;0.00072)|all_lung(10;0.000847)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)														---	---	---	---
ANKRD7	56311	broad.mit.edu	37	7	117867989	117867989	+	Intron	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:117867989T>C	uc003vji.2	+							NM_019644	NP_062618			ankyrin repeat domain 7						male gonad development						0																		---	---	---	---
SLC13A1	6561	broad.mit.edu	37	7	122809232	122809232	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:122809232C>T	uc003vkm.2	-	4	548	c.523G>A	c.(523-525)GGA>AGA	p.G175R	SLC13A1_uc010lks.2_5'UTR	NM_022444	NP_071889	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate	175						integral to membrane|plasma membrane	sodium:sulfate symporter activity			ovary(2)	2					Succinic acid(DB00139)													---	---	---	---
SND1	27044	broad.mit.edu	37	7	127447559	127447559	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:127447559C>T	uc003vmi.2	+	11	1400	c.1174C>T	c.(1174-1176)CCC>TCC	p.P392S	SND1_uc010lle.2_Missense_Mutation_p.P45S	NM_014390	NP_055205	Q7KZF4	SND1_HUMAN	staphylococcal nuclease domain containing 1	392	Nuclear localization signal (Potential).|TNase-like 3.				gene silencing by RNA|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	melanosome|nucleus|RNA-induced silencing complex	nuclease activity|nucleic acid binding|protein binding|transcription cofactor activity			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
CCDC136	64753	broad.mit.edu	37	7	128452101	128452101	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:128452101G>A	uc003vnv.1	+	13	2643	c.2276G>A	c.(2275-2277)CGC>CAC	p.R759H	CCDC136_uc003vnu.1_Intron|CCDC136_uc003vnw.1_Intron|CCDC136_uc003vnx.1_Missense_Mutation_p.R575H|CCDC136_uc010llq.1_Missense_Mutation_p.R128H|CCDC136_uc003vny.1_Missense_Mutation_p.R369H	NM_022742	NP_073579	Q96JN2	CC136_HUMAN	coiled-coil domain containing 136	759						integral to membrane	protein binding			ovary(2)	2																		---	---	---	---
FLNC	2318	broad.mit.edu	37	7	128470849	128470849	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:128470849T>C	uc003vnz.3	+	1	367	c.158T>C	c.(157-159)GTG>GCG	p.V53A	FLNC_uc003voa.3_Missense_Mutation_p.V53A	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	53	CH 1.|Actin-binding.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12																		---	---	---	---
FLNC	2318	broad.mit.edu	37	7	128483926	128483926	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:128483926C>A	uc003vnz.3	+	19	3097	c.2888C>A	c.(2887-2889)CCG>CAG	p.P963Q	FLNC_uc003voa.3_Missense_Mutation_p.P963Q	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	963	Filamin 8.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12																		---	---	---	---
FLNC	2318	broad.mit.edu	37	7	128494600	128494600	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:128494600G>T	uc003vnz.3	+	41	7070	c.6861G>T	c.(6859-6861)ACG>ACT	p.T2287T	FLNC_uc003voa.3_Silent_p.T2254T	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	2287	Filamin 20.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12																		---	---	---	---
PLXNA4	91584	broad.mit.edu	37	7	131831339	131831339	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:131831339T>C	uc003vra.3	-	28	5214	c.4985A>G	c.(4984-4986)GAC>GGC	p.D1662G	PLXNA4_uc003vqz.3_5'Flank	NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1662	Cytoplasmic (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1																		---	---	---	---
NUP205	23165	broad.mit.edu	37	7	135292023	135292023	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:135292023T>C	uc003vsw.2	+	22	3130	c.3099T>C	c.(3097-3099)CTT>CTC	p.L1033L		NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	1033					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6																		---	---	---	---
CHRM2	1129	broad.mit.edu	37	7	136700105	136700105	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:136700105A>T	uc003vtf.1	+	4	1116	c.493A>T	c.(493-495)ATT>TTT	p.I165F	CHRM2_uc003vtg.1_Missense_Mutation_p.I165F|CHRM2_uc003vtj.1_Missense_Mutation_p.I165F|CHRM2_uc003vtk.1_Missense_Mutation_p.I165F|CHRM2_uc003vtl.1_Missense_Mutation_p.I165F|CHRM2_uc003vtm.1_Missense_Mutation_p.I165F|CHRM2_uc003vti.1_Missense_Mutation_p.I165F|CHRM2_uc003vto.1_Missense_Mutation_p.I165F|CHRM2_uc003vtn.1_Missense_Mutation_p.I165F|uc003vtp.1_Intron	NM_001006630	NP_001006631	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	165	Extracellular (By similarity).				activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			ovary(4)|central_nervous_system(1)	5					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)													---	---	---	---
TRIM24	8805	broad.mit.edu	37	7	138265376	138265376	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:138265376C>A	uc003vuc.2	+	16	2870	c.2655C>A	c.(2653-2655)CCC>CCA	p.P885P	TRIM24_uc003vub.2_Silent_p.P851P	NM_015905	NP_056989	O15164	TIF1A_HUMAN	transcriptional intermediary factor 1 alpha	885					cellular response to estrogen stimulus|protein catabolic process|regulation of apoptosis|regulation of protein stability|transcription from RNA polymerase II promoter	cytoplasm	chromatin binding|estrogen response element binding|histone acetyl-lysine binding|p53 binding|transcription coactivator activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(3)|ovary(2)|stomach(1)|breast(1)|skin(1)	8																		---	---	---	---
SVOPL	136306	broad.mit.edu	37	7	138312947	138312947	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:138312947G>A	uc011kqh.1	-	10	1025	c.1025C>T	c.(1024-1026)TCT>TTT	p.S342F	SVOPL_uc003vue.2_Missense_Mutation_p.S190F	NM_001139456	NP_001132928	Q8N434	SVOPL_HUMAN	SVOP-like isoform 1	342						integral to membrane	transmembrane transporter activity				0																		---	---	---	---
SVOPL	136306	broad.mit.edu	37	7	138333866	138333866	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:138333866C>T	uc011kqh.1	-	7	551	c.551G>A	c.(550-552)GGC>GAC	p.G184D	SVOPL_uc003vue.2_Missense_Mutation_p.G32D	NM_001139456	NP_001132928	Q8N434	SVOPL_HUMAN	SVOP-like isoform 1	184	Helical; (Potential).					integral to membrane	transmembrane transporter activity				0																		---	---	---	---
BRAF	673	broad.mit.edu	37	7	140434395	140434395	+	3'UTR	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:140434395T>C	uc003vwc.3	-	18						NM_004333	NP_004324			B-Raf						activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)		61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				---	---	---	---
KIAA1147	57189	broad.mit.edu	37	7	141365032	141365032	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:141365032C>T	uc003vwk.2	-	6	907	c.907G>A	c.(907-909)GTG>ATG	p.V303M		NM_001080392	NP_001073861	A4D1U4	LCHN_HUMAN	hypothetical protein LOC57189	303										ovary(1)	1	Melanoma(164;0.0171)																	---	---	---	---
WEE2	494551	broad.mit.edu	37	7	141408668	141408668	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:141408668C>T	uc003vwn.2	+	1	516	c.110C>T	c.(109-111)TCG>TTG	p.S37L	FLJ40852_uc011krh.1_Intron|FLJ40852_uc010lnm.2_Intron|FLJ40852_uc010lnn.2_Intron|FLJ40852_uc003vwm.3_Intron|FLJ40852_uc010lno.2_Intron	NM_001105558	NP_001099028	P0C1S8	WEE2_HUMAN	WEE1 homolog 2	37					egg activation|female meiosis|female pronucleus assembly|meiotic metaphase II|meiotic prophase I|mitosis|negative regulation of oocyte development|regulation of meiosis I	centrosome|nucleus	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2	Melanoma(164;0.0171)																	---	---	---	---
Unknown	0	broad.mit.edu	37	7	142008730	142008730	+	Intron	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:142008730A>G	uc011kro.1	+						uc011krp.1_5'Flank|uc003vxf.3_Missense_Mutation_p.Y68C					SubName: Full=V_segment translation product; Flags: Fragment;																														---	---	---	---
OR2F2	135948	broad.mit.edu	37	7	143632813	143632813	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:143632813C>G	uc011ktv.1	+	1	488	c.488C>G	c.(487-489)ACC>AGC	p.T163S		NM_001004685	NP_001004685	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F,	163	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	Melanoma(164;0.0903)																	---	---	---	---
CUL1	8454	broad.mit.edu	37	7	148464776	148464776	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:148464776T>G	uc010lpg.2	+	9	1544	c.1018T>G	c.(1018-1020)TTG>GTG	p.L340V	CUL1_uc003wey.2_Missense_Mutation_p.L340V|CUL1_uc003wez.2_Missense_Mutation_p.L230V	NM_003592	NP_003583	Q13616	CUL1_HUMAN	cullin 1	340					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			lung(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)															---	---	---	---
Unknown	0	broad.mit.edu	37	7	148963504	148963504	+	RNA	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:148963504T>C	uc003wfr.3	+	2		c.266T>C								Homo sapiens cDNA FLJ36716 fis, clone UTERU2010651.																														---	---	---	---
ABP1	26	broad.mit.edu	37	7	150554663	150554663	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:150554663A>G	uc003why.1	+	3	5323	c.1105A>G	c.(1105-1107)ACC>GCC	p.T369A	ABP1_uc003whz.1_Missense_Mutation_p.T369A|ABP1_uc003wia.1_Missense_Mutation_p.T369A	NM_001091	NP_001082	P19801	ABP1_HUMAN	amiloride binding protein 1 precursor	369					amine metabolic process	extracellular space|peroxisome	copper ion binding|diamine oxidase activity|heparin binding|histamine oxidase activity|methylputrescine oxidase activity|primary amine oxidase activity|propane-1,3-diamine oxidase activity|quinone binding			ovary(2)|breast(2)|skin(2)	6	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiloride(DB00594)|Spermine(DB00127)													---	---	---	---
ACCN3	9311	broad.mit.edu	37	7	150747861	150747861	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:150747861C>T	uc003win.2	+	4	1198	c.830C>T	c.(829-831)CCG>CTG	p.P277L	ACCN3_uc003wio.2_Missense_Mutation_p.P277L|ACCN3_uc003wip.2_Missense_Mutation_p.P277L|ACCN3_uc003wiq.2_RNA	NM_004769	NP_004760	Q9UHC3	ACCN3_HUMAN	amiloride-sensitive cation channel 3 isoform a	277	Extracellular (Potential).				sensory perception|signal transduction	cytoplasm|integral to plasma membrane	ligand-gated sodium channel activity	p.P277S(1)		ovary(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)														---	---	---	---
MLL3	58508	broad.mit.edu	37	7	151891595	151891595	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:151891595A>G	uc003wla.2	-	29	4656	c.4437T>C	c.(4435-4437)AGT>AGC	p.S1479S	MLL3_uc003wkz.2_Silent_p.S540S	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1479					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)				N		medulloblastoma								---	---	---	---
HTR5A	3361	broad.mit.edu	37	7	154863162	154863162	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:154863162T>C	uc003wlu.1	+	1	617	c.553T>C	c.(553-555)TAC>CAC	p.Y185H	uc011kvt.1_5'UTR|uc003wlt.2_5'UTR	NM_024012	NP_076917	P47898	5HT5A_HUMAN	5-hydroxytryptamine receptor 5A	185	Extracellular (By similarity).					integral to plasma membrane	serotonin receptor activity			ovary(2)|large_intestine(1)	3	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)														---	---	---	---
NOM1	64434	broad.mit.edu	37	7	156745292	156745292	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:156745292G>T	uc003wmy.2	+	2	1127	c.1112G>T	c.(1111-1113)AGG>ATG	p.R371M		NM_138400	NP_612409	Q5C9Z4	NOM1_HUMAN	nucleolar protein with MIF4G domain 1	371	MIF4G.				RNA metabolic process	nucleolus	protein binding				0	Ovarian(565;0.218)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00301)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)														---	---	---	---
WDR60	55112	broad.mit.edu	37	7	158711457	158711457	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:158711457T>C	uc003woe.3	+	15	1976	c.1818T>C	c.(1816-1818)GAT>GAC	p.D606D	WDR60_uc010lqv.2_RNA|WDR60_uc010lqw.2_Silent_p.D238D	NM_018051	NP_060521	Q8WVS4	WDR60_HUMAN	WD repeat domain 60	606										ovary(2)|breast(1)|central_nervous_system(1)	4	Ovarian(565;0.152)	all_cancers(7;1.25e-09)|all_epithelial(9;0.000894)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)|STAD - Stomach adenocarcinoma(7;0.18)														---	---	---	---
ZNF596	169270	broad.mit.edu	37	8	195403	195403	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:195403A>C	uc003wot.2	+	6	844	c.556A>C	c.(556-558)AGT>CGT	p.S186R	ZNF596_uc003wou.2_Missense_Mutation_p.S85R|ZNF596_uc003wov.2_Missense_Mutation_p.S186R|ZNF596_uc003wow.2_Missense_Mutation_p.S186R	NM_173539	NP_775810	Q8TC21	ZN596_HUMAN	zinc finger protein 596	186					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(2;4.81e-29)|all_epithelial(2;5.03e-19)|Lung NSC(2;8.68e-08)|all_lung(2;1.52e-07)|Ovarian(12;0.00965)|Colorectal(14;0.0367)|all_neural(12;0.0837)|Myeloproliferative disorder(644;0.116)|all_hematologic(2;0.138)|Acute lymphoblastic leukemia(644;0.242)		Epithelial(5;3.77e-18)|all cancers(2;5.2e-17)|OV - Ovarian serous cystadenocarcinoma(5;5.37e-09)|BRCA - Breast invasive adenocarcinoma(11;1.7e-06)|Colorectal(2;6.51e-05)|READ - Rectum adenocarcinoma(2;0.0276)|COAD - Colon adenocarcinoma(149;0.0702)														---	---	---	---
FBXO25	26260	broad.mit.edu	37	8	408486	408486	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:408486T>C	uc003wox.2	+	8	1044	c.778T>C	c.(778-780)TAT>CAT	p.Y260H	FBXO25_uc003woy.2_Missense_Mutation_p.Y260H|FBXO25_uc003woz.2_Missense_Mutation_p.Y193H|FBXO25_uc003wpa.2_Missense_Mutation_p.Y43H	NM_183421	NP_904357	Q8TCJ0	FBX25_HUMAN	F-box only protein 25 isoform 1	260	F-box.					nucleus|SCF ubiquitin ligase complex	actin binding|ubiquitin-protein ligase activity			lung(1)	1		Ovarian(12;0.00965)|Colorectal(14;0.0815)|Myeloproliferative disorder(644;0.116)|all_neural(12;0.122)		Epithelial(5;3.14e-14)|OV - Ovarian serous cystadenocarcinoma(5;1.56e-07)|BRCA - Breast invasive adenocarcinoma(11;1.88e-06)														---	---	---	---
DLGAP2	9228	broad.mit.edu	37	8	1649527	1649527	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:1649527G>A	uc003wpl.2	+	12	2980	c.2883G>A	c.(2881-2883)GCG>GCA	p.A961A	DLGAP2_uc003wpm.2_Silent_p.A947A	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	1040					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)														---	---	---	---
MYOM2	9172	broad.mit.edu	37	8	2044108	2044108	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:2044108G>A	uc003wpx.3	+	18	2285	c.2147G>A	c.(2146-2148)GGG>GAG	p.G716E	MYOM2_uc011kwi.1_Missense_Mutation_p.G141E	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	716	Fibronectin type-III 4.				muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)														---	---	---	---
DEFA6	1671	broad.mit.edu	37	8	6783453	6783453	+	Missense_Mutation	SNP	C	A	A	rs113837602	byFrequency;by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:6783453C>A	uc003wqt.2	-	1	146	c.105G>T	c.(103-105)GAG>GAT	p.E35D		NM_001926	NP_001917	Q01524	DEF6_HUMAN	defensin, alpha 6 preproprotein	35					defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space					0			STAD - Stomach adenocarcinoma(24;0.0322)	COAD - Colon adenocarcinoma(149;0.0572)|READ - Rectum adenocarcinoma(644;0.121)														---	---	---	---
MFHAS1	9258	broad.mit.edu	37	8	8749149	8749149	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:8749149T>C	uc003wsj.1	-	1	1983	c.1420A>G	c.(1420-1422)ATC>GTC	p.I474V		NM_004225	NP_004216	Q9Y4C4	MFHA1_HUMAN	malignant fibrous histiocytoma amplified	474	Roc.										0		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.124)														---	---	---	---
PSD3	23362	broad.mit.edu	37	8	18729499	18729499	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:18729499C>T	uc003wza.2	-	3	978	c.875G>A	c.(874-876)CGC>CAC	p.R292H		NM_015310	NP_056125	Q9NYI0	PSD3_HUMAN	ADP-ribosylation factor guanine nucleotide	292					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)														---	---	---	---
LZTS1	11178	broad.mit.edu	37	8	20110461	20110461	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:20110461C>T	uc003wzr.2	-	2	1092	c.981G>A	c.(979-981)GCG>GCA	p.A327A	LZTS1_uc010ltg.1_Silent_p.A327A	NM_021020	NP_066300	Q9Y250	LZTS1_HUMAN	leucine zipper, putative tumor suppressor 1	327	Potential.				cell cycle|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	cell junction|dendritic spine|Golgi apparatus|nucleolus|nucleoplasm|postsynaptic density|postsynaptic membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				Colorectal(74;0.0511)|COAD - Colon adenocarcinoma(73;0.207)														---	---	---	---
LZTS1	11178	broad.mit.edu	37	8	20110845	20110845	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:20110845G>T	uc003wzr.2	-	2	708	c.597C>A	c.(595-597)CCC>CCA	p.P199P	LZTS1_uc010ltg.1_Silent_p.P199P	NM_021020	NP_066300	Q9Y250	LZTS1_HUMAN	leucine zipper, putative tumor suppressor 1	199					cell cycle|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	cell junction|dendritic spine|Golgi apparatus|nucleolus|nucleoplasm|postsynaptic density|postsynaptic membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				Colorectal(74;0.0511)|COAD - Colon adenocarcinoma(73;0.207)														---	---	---	---
XPO7	23039	broad.mit.edu	37	8	21835279	21835279	+	Splice_Site	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:21835279A>G	uc003xaa.3	+	8	866	c.764_splice	c.e8-2	p.A255_splice	XPO7_uc010lti.2_Splice_Site_p.A264_splice|XPO7_uc010ltk.2_Splice_Site_p.A256_splice	NM_015024	NP_055839			exportin 7 isoform b						mRNA transport|protein export from nucleus|transmembrane transport	cytoplasm|nuclear pore	nuclear export signal receptor activity|protein transporter activity			ovary(1)|kidney(1)|breast(1)|central_nervous_system(1)|pancreas(1)	5				Colorectal(74;0.0187)|COAD - Colon adenocarcinoma(73;0.0724)														---	---	---	---
XPO7	23039	broad.mit.edu	37	8	21846547	21846547	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:21846547A>G	uc003xaa.3	+	16	1923	c.1821A>G	c.(1819-1821)GAA>GAG	p.E607E	XPO7_uc010lti.2_Silent_p.E616E|XPO7_uc010ltk.2_Silent_p.E608E	NM_015024	NP_055839	Q9UIA9	XPO7_HUMAN	exportin 7 isoform b	607					mRNA transport|protein export from nucleus|transmembrane transport	cytoplasm|nuclear pore	nuclear export signal receptor activity|protein transporter activity			ovary(1)|kidney(1)|breast(1)|central_nervous_system(1)|pancreas(1)	5				Colorectal(74;0.0187)|COAD - Colon adenocarcinoma(73;0.0724)														---	---	---	---
HR	55806	broad.mit.edu	37	8	21973915	21973915	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:21973915G>A	uc003xas.2	-	18	4070	c.3405C>T	c.(3403-3405)AGC>AGT	p.S1135S	HR_uc003xat.2_Silent_p.S1080S	NM_005144	NP_005135	O43593	HAIR_HUMAN	hairless protein isoform a	1135	JmjC.						DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)														---	---	---	---
C8orf58	541565	broad.mit.edu	37	8	22458605	22458605	+	Missense_Mutation	SNP	C	A	A	rs11552429		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:22458605C>A	uc003xce.2	+	2	363	c.251C>A	c.(250-252)CCG>CAG	p.P84Q	C8orf58_uc011kzl.1_Missense_Mutation_p.P84Q|C8orf58_uc003xcf.2_Missense_Mutation_p.P84Q	NM_001013842	NP_001013864	Q8NAV2	CH058_HUMAN	hypothetical protein LOC541565	84										skin(1)	1		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00563)|Colorectal(74;0.0145)|COAD - Colon adenocarcinoma(73;0.0608)														---	---	---	---
TNFRSF10A	8797	broad.mit.edu	37	8	23058108	23058108	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:23058108C>A	uc003xda.2	-	6	774	c.709G>T	c.(709-711)GGA>TGA	p.G237*		NM_003844	NP_003835	O00220	TR10A_HUMAN	tumor necrosis factor receptor superfamily,	237	Extracellular (Potential).				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors		caspase activator activity|death receptor activity|TRAIL binding|transcription factor binding			central_nervous_system(3)|ovary(2)|skin(1)	6		Prostate(55;0.0421)|Breast(100;0.14)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)														---	---	---	---
ENTPD4	9583	broad.mit.edu	37	8	23302035	23302035	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:23302035C>A	uc003xdl.2	-	5	661	c.497G>T	c.(496-498)CGG>CTG	p.R166L	ENTPD4_uc011kzu.1_Missense_Mutation_p.R166L|ENTPD4_uc003xdm.2_Missense_Mutation_p.R166L|ENTPD4_uc011kzv.1_Missense_Mutation_p.R166L|ENTPD4_uc011kzw.1_Missense_Mutation_p.R132L	NM_004901	NP_004892	Q9Y227	ENTP4_HUMAN	ectonucleoside triphosphate diphosphohydrolase 4	166	Lumenal (Potential).				UDP catabolic process	autophagic vacuole membrane|cytoplasmic vesicle|integral to Golgi membrane	uridine-diphosphatase activity			ovary(1)|kidney(1)	2		Prostate(55;0.114)		Colorectal(74;0.0161)|COAD - Colon adenocarcinoma(73;0.0649)														---	---	---	---
ADAM7	8756	broad.mit.edu	37	8	24323272	24323272	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:24323272A>G	uc003xeb.2	+	5	486	c.373A>G	c.(373-375)ACG>GCG	p.T125A	ADAM7_uc003xea.1_Missense_Mutation_p.T125A	NM_003817	NP_003808	Q9H2U9	ADAM7_HUMAN	a disintegrin and metalloproteinase domain 7	125	Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(1)|kidney(1)	5		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)														---	---	---	---
DOCK5	80005	broad.mit.edu	37	8	25154129	25154129	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:25154129T>C	uc003xeg.2	+	7	708	c.571T>C	c.(571-573)TCC>CCC	p.S191P	DOCK5_uc010luf.1_RNA|DOCK5_uc003xeh.1_5'UTR|DOCK5_uc003xef.2_Missense_Mutation_p.S191P	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	191						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)														---	---	---	---
GNRH1	2796	broad.mit.edu	37	8	25280721	25280721	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:25280721A>G	uc003xem.3	-	2	967	c.126T>C	c.(124-126)ATT>ATC	p.I42I	PPP2R2A_uc003xek.2_Intron|GNRH1_uc003xen.3_Silent_p.I42I	NM_001083111	NP_001076580	P01148	GON1_HUMAN	gonadotropin-releasing hormone 1 precursor	42					cell-cell signaling|multicellular organismal development|negative regulation of cell proliferation|signal transduction	soluble fraction	gonadotropin hormone-releasing hormone activity			large_intestine(1)	1		all_cancers(63;0.0423)|Ovarian(32;0.000626)|all_epithelial(46;0.0186)|Hepatocellular(4;0.114)|Breast(100;0.14)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0201)|Epithelial(17;1.25e-12)|Colorectal(74;0.0113)|COAD - Colon adenocarcinoma(73;0.0385)														---	---	---	---
CDCA2	157313	broad.mit.edu	37	8	25364904	25364904	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:25364904A>G	uc003xep.1	+	15	3201	c.2722A>G	c.(2722-2724)ATT>GTT	p.I908V	PPP2R2A_uc003xek.2_Intron|CDCA2_uc011lae.1_3'UTR|CDCA2_uc003xeq.1_Missense_Mutation_p.I893V|CDCA2_uc003xer.1_Missense_Mutation_p.I571V	NM_152562	NP_689775	Q69YH5	CDCA2_HUMAN	cell division cycle associated 2	908					cell division|mitosis	cytoplasm|nucleus					0		all_cancers(63;0.0378)|Ovarian(32;0.000878)|all_epithelial(46;0.0162)|Breast(100;0.0164)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.022)|Epithelial(17;1.37e-11)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0443)														---	---	---	---
STMN4	81551	broad.mit.edu	37	8	27101222	27101222	+	Intron	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:27101222A>G	uc003xfk.2	-						STMN4_uc003xfj.2_Intron|STMN4_uc011lai.1_Intron|STMN4_uc011laj.1_Intron|STMN4_uc011lak.1_Intron|STMN4_uc010luo.2_Intron					RecName: Full=Stathmin-4; AltName: Full=Stathmin-like protein B3;          Short=RB3;						intracellular signal transduction					large_intestine(1)|pancreas(1)	2		Ovarian(32;0.00167)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0214)|Epithelial(17;9.82e-10)|Colorectal(74;0.142)														---	---	---	---
PTK2B	2185	broad.mit.edu	37	8	27287640	27287640	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:27287640A>G	uc003xfn.1	+	11	1390	c.582A>G	c.(580-582)GCA>GCG	p.A194A	PTK2B_uc003xfo.1_Silent_p.A194A|PTK2B_uc003xfp.1_Silent_p.A194A|PTK2B_uc003xfq.1_Silent_p.A194A|PTK2B_uc010luq.1_5'Flank|PTK2B_uc003xfr.1_5'Flank	NM_173174	NP_775266	Q14289	FAK2_HUMAN	PTK2B protein tyrosine kinase 2 beta isoform a	194	FERM.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			lung(3)|ovary(1)|skin(1)	5		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)														---	---	---	---
EXTL3	2137	broad.mit.edu	37	8	28575031	28575031	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:28575031G>A	uc003xgz.1	+	3	2048	c.1455G>A	c.(1453-1455)GTG>GTA	p.V485V		NM_001440	NP_001431	O43909	EXTL3_HUMAN	exostoses-like 3	485	Lumenal (Potential).					integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding|protein binding			skin(2)	2		Ovarian(32;0.069)		KIRC - Kidney renal clear cell carcinoma(542;0.107)|Kidney(114;0.129)|Colorectal(74;0.228)														---	---	---	---
TEX15	56154	broad.mit.edu	37	8	30702068	30702068	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:30702068T>G	uc003xil.2	-	1	4466	c.4466A>C	c.(4465-4467)TAC>TCC	p.Y1489S		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	1489										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)														---	---	---	---
NRG1	3084	broad.mit.edu	37	8	32600231	32600231	+	Intron	SNP	A	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:32600231A>T	uc003xiv.2	+						NRG1_uc003xip.2_Missense_Mutation_p.Y405F|NRG1_uc010lvn.2_Missense_Mutation_p.Y190F|NRG1_uc003xis.2_Missense_Mutation_p.Y224F|NRG1_uc011lbf.1_Missense_Mutation_p.Y224F|NRG1_uc010lvo.2_Missense_Mutation_p.Y224F|NRG1_uc003xiu.2_Missense_Mutation_p.Y224F|NRG1_uc003xiw.2_Missense_Mutation_p.Y224F|NRG1_uc003xit.2_Intron|NRG1_uc010lvr.2_Intron|NRG1_uc010lvs.2_Intron|NRG1_uc010lvp.2_Missense_Mutation_p.Y173F|NRG1_uc010lvq.2_Missense_Mutation_p.Y156F|NRG1_uc003xix.2_Missense_Mutation_p.T137S|NRG1_uc003xiy.2_Missense_Mutation_p.Y279F|NRG1_uc010lvt.2_Missense_Mutation_p.T236S|NRG1_uc011lbg.1_Intron|NRG1_uc011lbh.1_Missense_Mutation_p.Y70F|NRG1_uc003xiz.1_RNA|NRG1_uc003xja.2_Intron	NM_013964	NP_039258			neuregulin 1 isoform HRG-alpha						activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity				0		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)														---	---	---	---
UNC5D	137970	broad.mit.edu	37	8	35616995	35616995	+	Intron	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:35616995C>A	uc003xjr.1	+						UNC5D_uc003xjs.1_Intron|UNC5D_uc003xju.1_Intron	NM_080872	NP_543148			unc-5 homolog D precursor						apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)														---	---	---	---
WHSC1L1	54904	broad.mit.edu	37	8	38205098	38205098	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:38205098T>C	uc003xli.2	-	2	1110	c.592A>G	c.(592-594)AAA>GAA	p.K198E	WHSC1L1_uc011lbm.1_Missense_Mutation_p.K198E|WHSC1L1_uc010lwe.2_Missense_Mutation_p.K198E|WHSC1L1_uc003xlj.2_Missense_Mutation_p.K198E	NM_023034	NP_075447	Q9BZ95	NSD3_HUMAN	WHSC1L1 protein isoform long	198					cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)	1	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)					T	NUP98	AML								---	---	---	---
ANK1	286	broad.mit.edu	37	8	41552854	41552854	+	Intron	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:41552854G>T	uc003xok.2	-						NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Intron|ANK1_uc003xoi.2_Intron|ANK1_uc003xoj.2_Intron|ANK1_uc003xol.2_Intron|ANK1_uc003xom.2_Intron	NM_020476	NP_065209			ankyrin 1 isoform 1						axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)															---	---	---	---
MYST3	7994	broad.mit.edu	37	8	41814575	41814575	+	Intron	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:41814575G>A	uc010lxb.2	-						MYST3_uc010lxc.2_Intron|MYST3_uc003xon.3_Intron|MYST3_uc010lxd.2_Intron	NM_001099412	NP_001092882			MYST histone acetyltransferase (monocytic						histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)															---	---	---	---
PRKDC	5591	broad.mit.edu	37	8	48740750	48740750	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:48740750T>C	uc003xqi.2	-	63	8613	c.8556A>G	c.(8554-8556)CCA>CCG	p.P2852P	PRKDC_uc003xqj.2_Silent_p.P2852P|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	2852	KIP-binding.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)											NHEJ					---	---	---	---
PRKDC	5591	broad.mit.edu	37	8	48761849	48761849	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:48761849C>T	uc003xqi.2	-	55	7203	c.7146G>A	c.(7144-7146)GTG>GTA	p.V2382V	PRKDC_uc003xqj.2_Silent_p.V2382V|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	2382					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)											NHEJ					---	---	---	---
MCM4	4173	broad.mit.edu	37	8	48888391	48888391	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:48888391C>T	uc003xqk.1	+	16	2577	c.2482C>T	c.(2482-2484)CGG>TGG	p.R828W	MCM4_uc003xql.1_Missense_Mutation_p.R828W|MCM4_uc011ldi.1_Missense_Mutation_p.R815W	NM_182746	NP_877423	P33991	MCM4_HUMAN	minichromosome maintenance complex component 4	828					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(2)|skin(2)	4		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)																---	---	---	---
ST18	9705	broad.mit.edu	37	8	53126792	53126792	+	Missense_Mutation	SNP	G	A	A	rs145495470		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:53126792G>A	uc003xqz.2	-	2	182	c.26C>T	c.(25-27)ACG>ATG	p.T9M	ST18_uc011ldq.1_Translation_Start_Site|ST18_uc011ldr.1_Translation_Start_Site|ST18_uc011lds.1_Translation_Start_Site|ST18_uc003xra.2_Missense_Mutation_p.T9M|ST18_uc003xrb.2_Missense_Mutation_p.T9M|ST18_uc010lyb.2_RNA	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	9						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)																---	---	---	---
RB1CC1	9821	broad.mit.edu	37	8	53569170	53569170	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:53569170T>C	uc003xre.3	-	15	3777	c.3219A>G	c.(3217-3219)GAA>GAG	p.E1073E	RB1CC1_uc003xrf.3_Silent_p.E1073E	NM_014781	NP_055596	Q8TDY2	RBCC1_HUMAN	Rb1-inducible coiled coil protein 1 isoform 1	1073	Potential.				autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			ovary(8)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	11		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)																---	---	---	---
TGS1	96764	broad.mit.edu	37	8	56699432	56699432	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:56699432A>G	uc003xsj.3	+	4	1362	c.975A>G	c.(973-975)AAA>AAG	p.K325K	TGS1_uc010lyh.2_Silent_p.K229K	NM_024831	NP_079107	Q96RS0	TGS1_HUMAN	trimethylguanosine synthase homolog	325					cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			ovary(1)|lung(1)|breast(1)	3		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)															---	---	---	---
FAM110B	90362	broad.mit.edu	37	8	59059811	59059811	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:59059811G>A	uc003xtj.1	+	5	1902	c.1022G>A	c.(1021-1023)GGC>GAC	p.G341D		NM_147189	NP_671722	Q8TC76	F110B_HUMAN	hypothetical protein LOC90362	341						microtubule organizing center|mitochondrion|nucleus				large_intestine(1)	1		all_epithelial(80;0.025)|all_lung(136;0.0274)|Lung NSC(129;0.0355)																---	---	---	---
NSMAF	8439	broad.mit.edu	37	8	59502072	59502072	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:59502072A>G	uc003xtt.2	-	26	2364	c.2150T>C	c.(2149-2151)GTT>GCT	p.V717A	NSMAF_uc011lee.1_Missense_Mutation_p.V748A	NM_003580	NP_003571	Q92636	FAN_HUMAN	neutral sphingomyelinase (N-SMase) activation	717	WD 3.				ceramide metabolic process	cytoplasm|soluble fraction	protein binding|receptor signaling protein activity			ovary(1)	1		all_lung(136;0.174)|Lung NSC(129;0.2)																---	---	---	---
TOX	9760	broad.mit.edu	37	8	59739434	59739434	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:59739434T>C	uc003xtw.1	-	6	1173	c.952A>G	c.(952-954)AAG>GAG	p.K318E		NM_014729	NP_055544	O94900	TOX_HUMAN	thymus high mobility group box protein TOX	318	HMG box.					nucleus	DNA binding			kidney(2)|lung(1)|skin(1)	4		all_cancers(86;0.165)|Myeloproliferative disorder(644;0.00452)|all_lung(136;0.036)|Lung NSC(129;0.0464)|all_epithelial(80;0.0607)																---	---	---	---
CHD7	55636	broad.mit.edu	37	8	61654743	61654743	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:61654743A>G	uc003xue.2	+	2	1229	c.752A>G	c.(751-753)CAC>CGC	p.H251R		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	251					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)															---	---	---	---
BHLHE22	27319	broad.mit.edu	37	8	65494211	65494211	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:65494211C>T	uc003xvi.2	+	1	1398	c.864C>T	c.(862-864)CTC>CTT	p.L288L	LOC401463_uc003xvh.2_Intron	NM_152414	NP_689627	Q8NFJ8	BHE22_HUMAN	basic helix-loop-helix domain containing, class	288	Helix-loop-helix motif.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0																		---	---	---	---
MTFR1	9650	broad.mit.edu	37	8	66594621	66594621	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:66594621C>A	uc003xvm.2	+	3	312	c.100C>A	c.(100-102)CGA>AGA	p.R34R	MTFR1_uc011lep.1_Silent_p.R34R|MTFR1_uc003xvn.2_Intron|MTFR1_uc003xvo.1_Silent_p.R24R	NM_014637	NP_055452	Q15390	MTFR1_HUMAN	mitochondrial fission regulator 1 isoform 1	34						mitochondrion|plasma membrane				pancreas(1)	1			Epithelial(68;0.0526)|BRCA - Breast invasive adenocarcinoma(89;0.156)|all cancers(69;0.171)|OV - Ovarian serous cystadenocarcinoma(28;0.194)															---	---	---	---
TRIM55	84675	broad.mit.edu	37	8	67049351	67049351	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:67049351G>A	uc003xvv.2	+	4	755	c.529G>A	c.(529-531)GCC>ACC	p.A177T	TRIM55_uc003xvu.2_Missense_Mutation_p.A177T|TRIM55_uc003xvw.2_Missense_Mutation_p.A177T|TRIM55_uc003xvx.2_Missense_Mutation_p.A177T	NM_184085	NP_908973	Q9BYV6	TRI55_HUMAN	tripartite motif-containing 55 isoform 1	177	Potential.					cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)															---	---	---	---
C8orf46	254778	broad.mit.edu	37	8	67405952	67405952	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:67405952G>T	uc003xwg.2	+	1	462	c.69G>T	c.(67-69)AAG>AAT	p.K23N	C8orf46_uc003xwh.2_RNA|C8orf46_uc011let.1_Missense_Mutation_p.K23N	NM_152765	NP_689978	Q8TAG6	CH046_HUMAN	hypothetical protein LOC254778	23										skin(2)	2			Epithelial(68;0.0224)|BRCA - Breast invasive adenocarcinoma(89;0.0508)|all cancers(69;0.0558)|OV - Ovarian serous cystadenocarcinoma(28;0.226)															---	---	---	---
C8orf45	157777	broad.mit.edu	37	8	67796162	67796162	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:67796162C>T	uc003xwz.3	+	9	1177	c.1006C>T	c.(1006-1008)CGT>TGT	p.R336C	C8orf45_uc003xwv.2_Missense_Mutation_p.R336C|C8orf45_uc011lev.1_Missense_Mutation_p.R336C|C8orf45_uc011lew.1_Missense_Mutation_p.R267C|C8orf45_uc011lex.1_Missense_Mutation_p.R94C|C8orf45_uc003xwy.3_Missense_Mutation_p.R336C	NM_173518	NP_775789	Q4G0Z9	CH045_HUMAN	minichromosome maintenance complex	336					DNA replication		ATP binding|DNA binding			ovary(1)	1	Breast(64;0.186)		Epithelial(68;0.00384)|OV - Ovarian serous cystadenocarcinoma(28;0.00913)|all cancers(69;0.0175)|BRCA - Breast invasive adenocarcinoma(89;0.206)															---	---	---	---
C8orf45	157777	broad.mit.edu	37	8	67803170	67803170	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:67803170A>G	uc003xwz.3	+	10	1315	c.1144A>G	c.(1144-1146)ACT>GCT	p.T382A	C8orf45_uc011lev.1_Missense_Mutation_p.T382A|C8orf45_uc011lew.1_Missense_Mutation_p.T313A|C8orf45_uc011lex.1_Missense_Mutation_p.T140A|C8orf45_uc003xwy.3_Missense_Mutation_p.T382A	NM_173518	NP_775789	Q4G0Z9	CH045_HUMAN	minichromosome maintenance complex	382					DNA replication		ATP binding|DNA binding			ovary(1)	1	Breast(64;0.186)		Epithelial(68;0.00384)|OV - Ovarian serous cystadenocarcinoma(28;0.00913)|all cancers(69;0.0175)|BRCA - Breast invasive adenocarcinoma(89;0.206)															---	---	---	---
LRRC67	286187	broad.mit.edu	37	8	67922971	67922971	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:67922971G>A	uc003xxc.2	-	5	676	c.531C>T	c.(529-531)GAC>GAT	p.D177D		NM_001013626	NP_001013648	Q7Z4L9	LRC67_HUMAN	leucine rich repeat containing 67	177	LRR 7.										0																		---	---	---	---
SLCO5A1	81796	broad.mit.edu	37	8	70744467	70744467	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:70744467A>G	uc003xyl.2	-	2	1149	c.442T>C	c.(442-444)TAC>CAC	p.Y148H	SLCO5A1_uc010lzb.2_Missense_Mutation_p.Y148H|SLCO5A1_uc011lfa.1_RNA|SLCO5A1_uc003xyk.2_Missense_Mutation_p.Y148H|SLCO5A1_uc010lzc.2_Missense_Mutation_p.Y148H	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	148	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)													OREG0018815	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
TRPA1	8989	broad.mit.edu	37	8	72967924	72967924	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:72967924G>A	uc003xza.2	-	11	1536	c.1361C>T	c.(1360-1362)GCC>GTC	p.A454V		NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	454	ANK 11.|Cytoplasmic (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)													---	---	---	---
TRPA1	8989	broad.mit.edu	37	8	72981394	72981394	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:72981394T>C	uc003xza.2	-	3	483	c.308A>G	c.(307-309)CAT>CGT	p.H103R		NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	103	Cytoplasmic (Potential).|ANK 2.					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)													---	---	---	---
KCNB2	9312	broad.mit.edu	37	8	73849583	73849583	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:73849583G>T	uc003xzb.2	+	3	2581	c.1993G>T	c.(1993-1995)GGC>TGC	p.G665C		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	665	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)															---	---	---	---
PI15	51050	broad.mit.edu	37	8	75737657	75737657	+	Missense_Mutation	SNP	G	A	A	rs141788887	byFrequency;by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:75737657G>A	uc003yal.2	+	2	352	c.173G>A	c.(172-174)CGG>CAG	p.R58Q	uc003yak.1_Intron|PI15_uc003yam.2_Missense_Mutation_p.R58Q	NM_015886	NP_056970	O43692	PI15_HUMAN	protease inhibitor 15 preproprotein	58						extracellular region	peptidase inhibitor activity			central_nervous_system(2)|ovary(1)	3	Breast(64;0.137)		BRCA - Breast invasive adenocarcinoma(89;0.104)|Epithelial(68;0.118)															---	---	---	---
ZFHX4	79776	broad.mit.edu	37	8	77768496	77768496	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:77768496C>T	uc003yav.2	+	10	9591	c.9204C>T	c.(9202-9204)AAC>AAT	p.N3068N	ZFHX4_uc003yau.1_Silent_p.N3113N|ZFHX4_uc003yaw.1_Silent_p.N3068N	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	3068	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)												HNSCC(33;0.089)			---	---	---	---
PEX2	5828	broad.mit.edu	37	8	77896243	77896243	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:77896243C>T	uc003yax.2	-	4	630	c.172G>A	c.(172-174)GCG>ACG	p.A58T	PEX2_uc003yay.2_Missense_Mutation_p.A58T|PEX2_uc003yaz.2_Missense_Mutation_p.A58T	NM_000318	NP_000309	P28328	PEX2_HUMAN	peroxin 2	58					peroxisome organization	integral to peroxisomal membrane	protein binding|zinc ion binding			ovary(1)	1																		---	---	---	---
WWP1	11059	broad.mit.edu	37	8	87393036	87393036	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:87393036C>T	uc003ydt.2	+	4	432	c.152C>T	c.(151-153)ACG>ATG	p.T51M	WWP1_uc010mai.2_Translation_Start_Site	NM_007013	NP_008944	Q9H0M0	WWP1_HUMAN	WW domain containing E3 ubiquitin protein ligase	51	C2.				central nervous system development|entry of virus into host cell|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|signal transduction	cytoplasm|nucleus|plasma membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			lung(1)|liver(1)	2																		---	---	---	---
CNGB3	54714	broad.mit.edu	37	8	87591466	87591466	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:87591466C>G	uc003ydx.2	-	16	1842	c.1796G>C	c.(1795-1797)GGA>GCA	p.G599A	CNGB3_uc010maj.2_Missense_Mutation_p.G456A	NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	599	Cytoplasmic (Potential).|cGMP (By similarity).				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3																		---	---	---	---
RIPK2	8767	broad.mit.edu	37	8	90784971	90784971	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:90784971A>G	uc003yee.2	+	6	1082	c.768A>G	c.(766-768)CCA>CCG	p.P256P	RIPK2_uc003yef.2_Silent_p.P119P	NM_003821	NP_003812	O43353	RIPK2_HUMAN	receptor-interacting serine-threonine kinase 2	256	Protein kinase.				activation of MAPK activity|anti-apoptosis|apoptosis|inflammatory response|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein ubiquitination|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|CARD domain binding|LIM domain binding|protein homodimerization activity|protein serine/threonine kinase activity|signal transducer activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.0474)															---	---	---	---
CDH17	1015	broad.mit.edu	37	8	95142918	95142918	+	Missense_Mutation	SNP	G	T	T	rs141222335	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:95142918G>T	uc003ygh.2	-	17	2459	c.2334C>A	c.(2332-2334)CAC>CAA	p.H778Q	CDH17_uc011lgo.1_Intron|CDH17_uc011lgp.1_Missense_Mutation_p.H778Q	NM_004063	NP_004054	Q12864	CAD17_HUMAN	cadherin 17 precursor	778	Extracellular (Potential).					integral to membrane	calcium ion binding			ovary(5)|skin(1)	6	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)															---	---	---	---
RAD54B	25788	broad.mit.edu	37	8	95384421	95384421	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:95384421T>C	uc003ygk.2	-	15	2808	c.2710A>G	c.(2710-2712)ACC>GCC	p.T904A		NM_012415	NP_036547	O95073	FSBP_HUMAN	RAD54 homolog B	Error:Variant_position_missing_in_O95073_after_alignment					double-strand break repair via homologous recombination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA translocase activity|protein binding			kidney(2)|lung(1)|skin(1)	4	Breast(36;4.5e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00217)										Direct_reversal_of_damage|Homologous_recombination					---	---	---	---
KIAA1429	25962	broad.mit.edu	37	8	95543324	95543324	+	Intron	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:95543324A>G	uc003ygo.1	-						KIAA1429_uc003ygp.2_Intron	NM_015496	NP_056311			hypothetical protein LOC25962 isoform 1						mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)															---	---	---	---
ESRP1	54845	broad.mit.edu	37	8	95680231	95680231	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:95680231G>A	uc003ygq.3	+	10	1169	c.986G>A	c.(985-987)CGC>CAC	p.R329H	ESRP1_uc003ygr.3_Missense_Mutation_p.R329H|ESRP1_uc003ygs.3_Missense_Mutation_p.R329H|ESRP1_uc003ygt.3_Missense_Mutation_p.R329H|ESRP1_uc003ygu.3_Missense_Mutation_p.R329H|ESRP1_uc003ygv.2_Missense_Mutation_p.R169H|ESRP1_uc003ygw.2_Missense_Mutation_p.R169H	NM_017697	NP_060167	Q6NXG1	ESRP1_HUMAN	RNA binding motif protein 35A isoform 1	329	RRM 2.				mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	prostate(4)	4																		---	---	---	---
DPY19L4	286148	broad.mit.edu	37	8	95800209	95800209	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:95800209G>A	uc003ygx.2	+	18	2060	c.1936G>A	c.(1936-1938)GCT>ACT	p.A646T		NM_181787	NP_861452	Q7Z388	D19L4_HUMAN	dpy-19-like 4	646						integral to membrane				ovary(2)	2	Breast(36;3.85e-06)																	---	---	---	---
RPL30	6156	broad.mit.edu	37	8	99054391	99054391	+	Intron	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:99054391G>A	uc003yif.2	-						RPL30_uc010mbk.1_Intron|SNORA72_uc003yig.1_RNA	NM_000989	NP_000980			ribosomal protein L30						endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	RNA binding|structural constituent of ribosome				0	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.192)															---	---	---	---
POP1	10940	broad.mit.edu	37	8	99170251	99170251	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:99170251C>A	uc003yij.3	+	16	2927	c.2827C>A	c.(2827-2829)CTG>ATG	p.L943M	POP1_uc011lgv.1_Missense_Mutation_p.L943M|POP1_uc003yik.2_Missense_Mutation_p.L943M	NM_001145860	NP_001139332	Q99575	POP1_HUMAN	processing of precursor 1	943					tRNA 5'-leader removal|tRNA catabolic process	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease MRP activity|ribonuclease P activity			ovary(1)|breast(1)	2	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.145)															---	---	---	---
KCNS2	3788	broad.mit.edu	37	8	99440298	99440298	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:99440298C>T	uc003yin.2	+	2	441	c.91C>T	c.(91-93)CGC>TGC	p.R31C		NM_020697	NP_065748	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel,	31	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)															---	---	---	---
VPS13B	157680	broad.mit.edu	37	8	100108587	100108587	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:100108587T>C	uc003yiv.2	+	4	450	c.339T>C	c.(337-339)GCT>GCC	p.A113A	VPS13B_uc003yiw.2_Silent_p.A113A|VPS13B_uc003yit.2_Silent_p.A113A|VPS13B_uc003yiu.1_Silent_p.A113A|VPS13B_uc003yis.2_Silent_p.A113A|VPS13B_uc011lgy.1_5'UTR	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	113					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)															---	---	---	---
VPS13B	157680	broad.mit.edu	37	8	100133550	100133550	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:100133550T>C	uc003yiv.2	+	8	1194	c.1083T>C	c.(1081-1083)GAT>GAC	p.D361D	VPS13B_uc003yiw.2_Silent_p.D361D|VPS13B_uc003yit.2_Silent_p.D361D|VPS13B_uc003yiu.1_Silent_p.D361D|VPS13B_uc003yis.2_Silent_p.D361D|VPS13B_uc011lgy.1_Silent_p.D237D	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	361					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)															---	---	---	---
RGS22	26166	broad.mit.edu	37	8	101092401	101092401	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:101092401G>T	uc003yjb.1	-	4	495	c.300C>A	c.(298-300)CCC>CCA	p.P100P	RGS22_uc003yja.1_Silent_p.P4P|RGS22_uc003yjc.1_Silent_p.P100P|RGS22_uc010mbo.1_RNA	NM_015668	NP_056483	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	100					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)															---	---	---	---
UBR5	51366	broad.mit.edu	37	8	103277510	103277510	+	Intron	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:103277510A>G	uc003ykr.1	-						UBR5_uc003yks.1_Intron|UBR5_uc003ykq.2_Intron	NM_015902	NP_056986			ubiquitin protein ligase E3 component n-recognin						cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)															---	---	---	---
UBR5	51366	broad.mit.edu	37	8	103292631	103292631	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:103292631T>C	uc003ykr.1	-	42	6025	c.5992A>G	c.(5992-5994)ACC>GCC	p.T1998A	UBR5_uc003yks.1_Missense_Mutation_p.T1998A	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	1998					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)															---	---	---	---
UBR5	51366	broad.mit.edu	37	8	103310725	103310725	+	Intron	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:103310725A>G	uc003ykr.1	-						UBR5_uc003yks.1_Intron	NM_015902	NP_056986			ubiquitin protein ligase E3 component n-recognin						cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)															---	---	---	---
SYBU	55638	broad.mit.edu	37	8	110656869	110656869	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:110656869C>T	uc003ynj.3	-	1	183	c.20G>A	c.(19-21)AGC>AAC	p.S7N	SYBU_uc003yni.3_5'Flank|SYBU_uc003ynk.3_5'UTR|SYBU_uc010mco.2_Missense_Mutation_p.S7N|SYBU_uc003ynl.3_Missense_Mutation_p.S7N|SYBU_uc010mcp.2_Missense_Mutation_p.S7N|SYBU_uc010mcq.2_Missense_Mutation_p.S7N|SYBU_uc003yno.3_Intron|SYBU_uc010mcr.2_Missense_Mutation_p.S7N|SYBU_uc003ynm.3_Missense_Mutation_p.S7N|SYBU_uc003ynn.3_Missense_Mutation_p.S7N|SYBU_uc010mcs.2_Intron|SYBU_uc010mct.2_Missense_Mutation_p.S7N|SYBU_uc010mcu.2_Missense_Mutation_p.S7N|SYBU_uc003ynp.3_Intron|SYBU_uc010mcv.2_Missense_Mutation_p.S7N|uc003ynq.1_Intron	NM_001099754	NP_001093224	Q9NX95	SYBU_HUMAN	Golgi-localized syntaphilin-related protein	7	Sufficient for interaction with KIF5B.					cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane				ovary(1)	1																		---	---	---	---
CSMD3	114788	broad.mit.edu	37	8	113256755	113256755	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:113256755C>A	uc003ynu.2	-	65	10429	c.10270G>T	c.(10270-10272)GGG>TGG	p.G3424W	CSMD3_uc003yns.2_Missense_Mutation_p.G2626W|CSMD3_uc003ynt.2_Missense_Mutation_p.G3384W|CSMD3_uc011lhx.1_Missense_Mutation_p.G3255W	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3424	Extracellular (Potential).|Sushi 28.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63															HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			---	---	---	---
TRPS1	7227	broad.mit.edu	37	8	116430589	116430589	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:116430589T>C	uc003ynz.2	-	5	3212	c.2753A>G	c.(2752-2754)AAC>AGC	p.N918S	TRPS1_uc011lhy.1_Missense_Mutation_p.N922S|TRPS1_uc003yny.2_Missense_Mutation_p.N931S|TRPS1_uc010mcy.2_Missense_Mutation_p.N918S	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	918	GATA-type.				negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)											Langer-Giedion_syndrome				---	---	---	---
TAF2	6873	broad.mit.edu	37	8	120795639	120795639	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:120795639A>G	uc003you.2	-	16	2364	c.2094T>C	c.(2092-2094)GCT>GCC	p.A698A		NM_003184	NP_003175	Q6P1X5	TAF2_HUMAN	TBP-associated factor 2	698					G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(2)|ovary(2)|kidney(1)|skin(1)	6	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)															---	---	---	---
TAF2	6873	broad.mit.edu	37	8	120818521	120818521	+	Splice_Site	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:120818521A>G	uc003you.2	-	4	688	c.418_splice	c.e4+1	p.E140_splice		NM_003184	NP_003175			TBP-associated factor 2						G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(2)|ovary(2)|kidney(1)|skin(1)	6	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)															---	---	---	---
SNTB1	6641	broad.mit.edu	37	8	121554212	121554212	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:121554212A>G	uc010mdg.2	-	6	1588	c.1362T>C	c.(1360-1362)CGT>CGC	p.R454R		NM_021021	NP_066301	Q13884	SNTB1_HUMAN	basic beta 1 syntrophin	454					muscle contraction	cell junction|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|calmodulin binding			skin(5)	5	Lung NSC(37;4.46e-09)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)		STAD - Stomach adenocarcinoma(47;0.00503)															---	---	---	---
HAS2	3037	broad.mit.edu	37	8	122641434	122641434	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:122641434A>G	uc003yph.2	-	2	685	c.147T>C	c.(145-147)TAT>TAC	p.Y49Y		NM_005328	NP_005319	Q92819	HAS2_HUMAN	hyaluronan synthase 2	49	Helical; Name=2; (Potential).					integral to plasma membrane	hyaluronan synthase activity		HAS2/PLAG1(10)	soft_tissue(10)|ovary(5)	15	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)															---	---	---	---
ZHX2	22882	broad.mit.edu	37	8	123964129	123964129	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:123964129G>A	uc003ypk.1	+	3	946	c.379G>A	c.(379-381)GAC>AAC	p.D127N		NM_014943	NP_055758	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	127	C2H2-type 2.					cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)															---	---	---	---
FAM83A	84985	broad.mit.edu	37	8	124204041	124204041	+	Splice_Site	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:124204041A>G	uc003ypv.2	+	3	2495	c.481_splice	c.e3-2	p.V161_splice	FAM83A_uc003ypw.2_Splice_Site_p.V161_splice|FAM83A_uc003ypy.2_Intron|FAM83A_uc003ypx.2_Splice_Site_p.V161_splice|FAM83A_uc003ypz.2_Splice_Site_p.V161_splice	NM_032899	NP_116288			hypothetical protein LOC84985 isoform a											ovary(3)|skin(1)	4	Lung NSC(37;1.55e-09)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)															---	---	---	---
ZHX1	11244	broad.mit.edu	37	8	124266020	124266020	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:124266020A>G	uc003yqe.2	-	3	2597	c.2167T>C	c.(2167-2169)TAC>CAC	p.Y723H	C8orf76_uc003yqd.2_Intron|ZHX1_uc003yqf.2_Missense_Mutation_p.Y723H|ZHX1_uc003yqg.2_Intron|ZHX1_uc010mdi.2_Missense_Mutation_p.Y723H	NM_007222	NP_009153	Q9UKY1	ZHX1_HUMAN	zinc fingers and homeoboxes 1	723					negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)															---	---	---	---
ATAD2	29028	broad.mit.edu	37	8	124340720	124340720	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:124340720G>A	uc003yqh.3	-	25	3686	c.3578C>T	c.(3577-3579)GCC>GTC	p.A1193V	ATAD2_uc011lii.1_Missense_Mutation_p.A984V|ATAD2_uc003yqi.3_RNA	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	1193					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)															---	---	---	---
FER1L6	654463	broad.mit.edu	37	8	125131154	125131154	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:125131154C>T	uc003yqw.2	+	40	5565	c.5359C>T	c.(5359-5361)CGA>TGA	p.R1787*	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1787	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)															---	---	---	---
SQLE	6713	broad.mit.edu	37	8	126011817	126011817	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:126011817C>T	uc011liq.1	+	1	1098	c.172C>T	c.(172-174)CAG>TAG	p.Q58*		NM_003129	NP_003120	Q14534	ERG1_HUMAN	squalene epoxidase	58				Q -> R (in Ref. 1; BAA22372).	cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome	flavin adenine dinucleotide binding|squalene monooxygenase activity			ovary(1)|breast(1)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)		Butenafine(DB01091)|Naftifine(DB00735)|Terbinafine(DB00857)													---	---	---	---
SQLE	6713	broad.mit.edu	37	8	126021227	126021227	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:126021227A>G	uc011liq.1	+	5	1763	c.837A>G	c.(835-837)CCA>CCG	p.P279P		NM_003129	NP_003120	Q14534	ERG1_HUMAN	squalene epoxidase	279					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome	flavin adenine dinucleotide binding|squalene monooxygenase activity			ovary(1)|breast(1)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)		Butenafine(DB01091)|Naftifine(DB00735)|Terbinafine(DB00857)													---	---	---	---
FAM49B	51571	broad.mit.edu	37	8	130861526	130861526	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:130861526T>C	uc003yss.2	-	13	1352	c.803A>G	c.(802-804)CAT>CGT	p.H268R	FAM49B_uc003yst.2_Missense_Mutation_p.H268R|FAM49B_uc003ysu.2_Missense_Mutation_p.H268R|FAM49B_uc003ysv.2_Missense_Mutation_p.H122R|FAM49B_uc003ysw.2_Missense_Mutation_p.H268R|FAM49B_uc003ysx.2_Missense_Mutation_p.H268R|FAM49B_uc003ysy.1_Missense_Mutation_p.H268R	NM_016623	NP_057707	Q9NUQ9	FA49B_HUMAN	hypothetical protein LOC51571	268											0	Ovarian(5;0.000567)|Esophageal squamous(12;0.00693)|Acute lymphoblastic leukemia(118;0.155)		LUAD - Lung adenocarcinoma(14;0.0989)															---	---	---	---
ASAP1	50807	broad.mit.edu	37	8	131124450	131124450	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:131124450C>T	uc003yta.1	-	23	2319	c.2291G>A	c.(2290-2292)CGG>CAG	p.R764Q	ASAP1_uc003ysz.1_Missense_Mutation_p.R575Q|ASAP1_uc011liw.1_Missense_Mutation_p.R757Q	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	764					cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4																		---	---	---	---
ASAP1	50807	broad.mit.edu	37	8	131172152	131172152	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:131172152T>C	uc003yta.1	-	11	996	c.968A>G	c.(967-969)TAT>TGT	p.Y323C	ASAP1_uc003ysz.1_Missense_Mutation_p.Y134C|ASAP1_uc011liw.1_Missense_Mutation_p.Y316C	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	323					cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4																		---	---	---	---
ASAP1	50807	broad.mit.edu	37	8	131226861	131226861	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:131226861T>C	uc003yta.1	-	4	374	c.346A>G	c.(346-348)ACC>GCC	p.T116A	ASAP1_uc011liw.1_Missense_Mutation_p.T109A	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	116					cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4																		---	---	---	---
KCNQ3	3786	broad.mit.edu	37	8	133142242	133142242	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:133142242A>G	uc003ytj.2	-	15	2111	c.1886T>C	c.(1885-1887)GTT>GCT	p.V629A	KCNQ3_uc010mdt.2_Missense_Mutation_p.V617A	NM_004519	NP_004510	O43525	KCNQ3_HUMAN	potassium voltage-gated channel KQT-like protein	629					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)															---	---	---	---
ST3GAL1	6482	broad.mit.edu	37	8	134477028	134477028	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:134477028T>C	uc003yuk.2	-	7	1505	c.676A>G	c.(676-678)ATT>GTT	p.I226V	ST3GAL1_uc003yum.2_Missense_Mutation_p.I226V	NM_173344	NP_775479	Q11201	SIA4A_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase	226	Lumenal (Potential).				protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,3-sialyltransferase activity				0	all_epithelial(106;1.53e-23)|Lung NSC(106;3.15e-07)|all_lung(105;1.26e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.00721)															---	---	---	---
COL22A1	169044	broad.mit.edu	37	8	139890149	139890149	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:139890149C>T	uc003yvd.2	-	3	949	c.502G>A	c.(502-504)GCT>ACT	p.A168T		NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	168	VWFA.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)												HNSCC(7;0.00092)			---	---	---	---
KCNK9	51305	broad.mit.edu	37	8	140631311	140631311	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:140631311C>A	uc003yvf.1	-	2	379	c.315G>T	c.(313-315)GCG>GCT	p.A105A	KCNK9_uc003yvg.1_Silent_p.A105A|KCNK9_uc003yve.1_RNA	NM_016601	NP_057685	Q9NPC2	KCNK9_HUMAN	potassium channel, subfamily K, member 9	105	Extracellular (Potential).					integral to membrane|membrane fraction	potassium channel activity|voltage-gated ion channel activity			ovary(2)|lung(1)	3	all_cancers(97;3.94e-14)|all_epithelial(106;4.81e-13)|Lung NSC(106;8.18e-05)|all_lung(105;0.00015)|Ovarian(258;0.00235)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;0.134)	BRCA - Breast invasive adenocarcinoma(115;0.0855)															---	---	---	---
TRAPPC9	83696	broad.mit.edu	37	8	141407709	141407709	+	Intron	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:141407709A>G	uc003yvj.2	-						TRAPPC9_uc003yvh.2_Intron|TRAPPC9_uc003yvi.1_Intron	NM_001160372	NP_001153844			trafficking protein particle complex 9 isoform						cell differentiation	endoplasmic reticulum|Golgi apparatus				skin(2)	2																		---	---	---	---
PSCA	8000	broad.mit.edu	37	8	143763436	143763436	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:143763436C>A	uc003ywu.2	+	3	313	c.258C>A	c.(256-258)TGC>TGA	p.C86*	uc003ywt.1_5'Flank	NM_005672	NP_005663	O43653	PSCA_HUMAN	prostate stem cell antigen preproprotein	77											0	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)																	---	---	---	---
ZC3H3	23144	broad.mit.edu	37	8	144620193	144620193	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:144620193G>T	uc003yyd.2	-	2	1373	c.1344C>A	c.(1342-1344)ATC>ATA	p.I448I		NM_015117	NP_055932	Q8IXZ2	ZC3H3_HUMAN	zinc finger CCCH-type containing 3	448					mRNA polyadenylation|poly(A)+ mRNA export from nucleus|regulation of mRNA export from nucleus	nucleus	nucleic acid binding|zinc ion binding			skin(1)	1	all_cancers(97;8.64e-11)|all_epithelial(106;6.43e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.107)															---	---	---	---
MAPK15	225689	broad.mit.edu	37	8	144800428	144800428	+	Missense_Mutation	SNP	G	T	T	rs145380962		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:144800428G>T	uc003yzj.2	+	4	283	c.242G>T	c.(241-243)CGG>CTG	p.R81L		NM_139021	NP_620590	Q8TD08	MK15_HUMAN	mitogen-activated protein kinase 15	81	Protein kinase.				protein autophosphorylation	extracellular region	ATP binding|MAP kinase activity|SH3 domain binding			lung(2)	2	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)															---	---	---	---
FAM83H	286077	broad.mit.edu	37	8	144811260	144811260	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:144811260A>G	uc003yzk.2	-	4	683	c.614T>C	c.(613-615)TTC>TCC	p.F205S	FAM83H_uc010mfk.1_5'Flank	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	205					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)															---	---	---	---
SCRIB	23513	broad.mit.edu	37	8	144891811	144891811	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:144891811G>A	uc003yzp.1	-	14	1615	c.1608C>T	c.(1606-1608)CCC>CCT	p.P536P	SCRIB_uc003yzo.1_Silent_p.P536P	NM_015356	NP_056171	Q14160	SCRIB_HUMAN	scribble isoform b	536	Sufficient for targeting to adherens junction and to inhibit cell proliferation.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)|pancreas(1)	5	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)															---	---	---	---
NRBP2	340371	broad.mit.edu	37	8	144917985	144917985	+	Intron	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:144917985C>T	uc011lkt.1	-						NRBP2_uc003yzv.2_Missense_Mutation_p.R238H|NRBP2_uc003yzz.1_Silent_p.A161A|NRBP2_uc003yzw.2_Intron|NRBP2_uc010mfl.2_Intron|NRBP2_uc010mfm.2_Intron|NRBP2_uc011lks.1_Intron|NRBP2_uc003yzy.2_Intron	NM_178564	NP_848659			nuclear receptor binding protein 2						negative regulation of neuron apoptosis|neuron differentiation	cytoplasm	ATP binding|protein kinase activity			central_nervous_system(2)	2	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)															---	---	---	---
PLEC	5339	broad.mit.edu	37	8	144993053	144993053	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:144993053G>A	uc003zaf.1	-	32	11517	c.11347C>T	c.(11347-11349)CGC>TGC	p.R3783C	PLEC_uc003zab.1_Missense_Mutation_p.R3646C|PLEC_uc003zac.1_Missense_Mutation_p.R3650C|PLEC_uc003zad.2_Missense_Mutation_p.R3646C|PLEC_uc003zae.1_Missense_Mutation_p.R3614C|PLEC_uc003zag.1_Missense_Mutation_p.R3624C|PLEC_uc003zah.2_Missense_Mutation_p.R3632C|PLEC_uc003zaj.2_Missense_Mutation_p.R3673C	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3783	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9																		---	---	---	---
PLEC	5339	broad.mit.edu	37	8	144994803	144994803	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:144994803G>T	uc003zaf.1	-	32	9767	c.9597C>A	c.(9595-9597)GCC>GCA	p.A3199A	PLEC_uc003zab.1_Silent_p.A3062A|PLEC_uc003zac.1_Silent_p.A3066A|PLEC_uc003zad.2_Silent_p.A3062A|PLEC_uc003zae.1_Silent_p.A3030A|PLEC_uc003zag.1_Silent_p.A3040A|PLEC_uc003zah.2_Silent_p.A3048A|PLEC_uc003zaj.2_Silent_p.A3089A	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3199	Globular 2.|Plectin 8.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9																		---	---	---	---
PLEC	5339	broad.mit.edu	37	8	144999422	144999422	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:144999422G>A	uc003zaf.1	-	31	5256	c.5086C>T	c.(5086-5088)CGA>TGA	p.R1696*	PLEC_uc003zab.1_Nonsense_Mutation_p.R1559*|PLEC_uc003zac.1_Nonsense_Mutation_p.R1563*|PLEC_uc003zad.2_Nonsense_Mutation_p.R1559*|PLEC_uc003zae.1_Nonsense_Mutation_p.R1527*|PLEC_uc003zag.1_Nonsense_Mutation_p.R1537*|PLEC_uc003zah.2_Nonsense_Mutation_p.R1545*|PLEC_uc003zaj.2_Nonsense_Mutation_p.R1586*	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	1696	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9																		---	---	---	---
GRINA	2907	broad.mit.edu	37	8	145066963	145066963	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145066963A>G	uc003zan.1	+	7	1236	c.1070A>G	c.(1069-1071)AAC>AGC	p.N357S	GRINA_uc003zao.1_Missense_Mutation_p.N357S|GRINA_uc003zap.1_Missense_Mutation_p.N357S	NM_001009184	NP_001009184	Q7Z429	GRINA_HUMAN	glutamate receptor, ionotropic, N-methyl	357	Helical; (Potential).					integral to membrane				central_nervous_system(1)	1	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)															---	---	---	---
OPLAH	26873	broad.mit.edu	37	8	145107485	145107485	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145107485A>G	uc003zar.3	-	23	3252	c.3170T>C	c.(3169-3171)GTG>GCG	p.V1057A		NM_017570	NP_060040	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	1057							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding				0	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)													---	---	---	---
COMMD5	28991	broad.mit.edu	37	8	146076258	146076258	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:146076258G>A	uc003zem.2	-	2	597	c.466C>T	c.(466-468)CGG>TGG	p.R156W	COMMD5_uc003zel.1_RNA|COMMD5_uc003zen.2_Missense_Mutation_p.R156W|COMMD5_uc003zeo.3_Missense_Mutation_p.R156W|COMMD5_uc010mgf.2_Missense_Mutation_p.R156W	NM_001081004	NP_001074473	Q9GZQ3	COMD5_HUMAN	COMM domain containing 5	156	COMM.					nucleus	protein binding			ovary(1)	1	all_cancers(97;1.14e-11)|all_epithelial(106;7.74e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;8.75e-39)|OV - Ovarian serous cystadenocarcinoma(54;1.13e-38)|all cancers(56;8.48e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)															---	---	---	---
CBWD1	55871	broad.mit.edu	37	9	164038	164038	+	Splice_Site	SNP	C	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:164038C>G	uc003zga.3	-	5	537	c.431_splice	c.e5-1	p.G144_splice	CBWD1_uc010mgs.2_Splice_Site|CBWD1_uc003zgb.3_Splice_Site_p.G108_splice|CBWD1_uc003zgc.3_Splice_Site_p.G144_splice|CBWD1_uc011llr.1_Splice_Site_p.G108_splice	NM_018491	NP_060961			COBW domain containing 1 isoform 1								ATP binding|protein binding			ovary(1)	1	all_lung(41;0.218)	all_cancers(5;3.04e-16)|all_epithelial(5;4.68e-12)|all_lung(10;1.94e-10)|Lung NSC(10;3.61e-10)|Acute lymphoblastic leukemia(5;0.00439)|Breast(48;0.0148)|all_hematologic(5;0.024)|Prostate(43;0.122)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)														---	---	---	---
DOCK8	81704	broad.mit.edu	37	9	382611	382611	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:382611A>G	uc003zgf.2	+	22	2816	c.2704A>G	c.(2704-2706)AGC>GGC	p.S902G	DOCK8_uc010mgu.2_Missense_Mutation_p.S204G|DOCK8_uc010mgv.2_Missense_Mutation_p.S834G|DOCK8_uc010mgw.1_Missense_Mutation_p.S204G|DOCK8_uc003zgk.2_Missense_Mutation_p.S360G	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	902					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)														---	---	---	---
KANK1	23189	broad.mit.edu	37	9	711872	711872	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:711872A>G	uc003zgl.1	+	7	1755	c.1106A>G	c.(1105-1107)CAA>CGA	p.Q369R	KANK1_uc003zgm.2_Missense_Mutation_p.Q369R|KANK1_uc003zgn.1_Missense_Mutation_p.Q369R|KANK1_uc003zgo.1_Missense_Mutation_p.Q369R|KANK1_uc003zgp.1_Missense_Mutation_p.Q369R|KANK1_uc003zgq.2_Missense_Mutation_p.Q211R|KANK1_uc003zgr.1_Missense_Mutation_p.Q211R|KANK1_uc003zgs.1_Missense_Mutation_p.Q211R	NM_015158	NP_055973	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1 isoform a	369	Potential.				negative regulation of actin filament polymerization	cytoplasm				ovary(2)|central_nervous_system(1)|pancreas(1)	4		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)														---	---	---	---
SMARCA2	6595	broad.mit.edu	37	9	2073627	2073627	+	Intron	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:2073627T>C	uc003zhc.2	+						SMARCA2_uc003zhd.2_Intron|SMARCA2_uc010mha.2_Intron	NM_003070	NP_003061			SWI/SNF-related matrix-associated						chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)														---	---	---	---
SMARCA2	6595	broad.mit.edu	37	9	2123850	2123850	+	Silent	SNP	A	G	G	rs141291951		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:2123850A>G	uc003zhc.2	+	27	3993	c.3894A>G	c.(3892-3894)GAA>GAG	p.E1298E	SMARCA2_uc003zhd.2_Silent_p.E1298E|SMARCA2_uc010mha.2_Silent_p.E1231E	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	1298	Poly-Glu.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)														---	---	---	---
RANBP6	26953	broad.mit.edu	37	9	6014994	6014994	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:6014994G>A	uc003zjr.2	-	1	625	c.614C>T	c.(613-615)GCA>GTA	p.A205V	RANBP6_uc011lmf.1_Intron|RANBP6_uc003zjs.2_Intron	NM_012416	NP_036548	O60518	RNBP6_HUMAN	RAN binding protein 6	205	Poly-Ala.				protein transport	cytoplasm|nucleus	binding			ovary(3)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)														---	---	---	---
GLDC	2731	broad.mit.edu	37	9	6645245	6645245	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:6645245C>T	uc003zkc.2	-	1	448	c.255G>A	c.(253-255)GCG>GCA	p.A85A		NM_000170	NP_000161	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	85					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			ovary(2)	2		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)													---	---	---	---
C9orf123	90871	broad.mit.edu	37	9	7799532	7799532	+	Intron	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:7799532A>G	uc003zki.2	-						C9orf123_uc003zkj.2_Missense_Mutation_p.V68A					Homo sapiens cDNA FLJ46908 fis, clone FEBRA2004867.							integral to membrane					0		all_cancers(3;0.0539)|Lung NSC(3;3.36e-05)|all_lung(3;0.000156)|all_epithelial(3;0.0356)		GBM - Glioblastoma multiforme(50;0.0561)														---	---	---	---
MPDZ	8777	broad.mit.edu	37	9	13205908	13205908	+	Intron	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:13205908G>A	uc010mia.1	-						MPDZ_uc010mhy.2_Intron|MPDZ_uc010mhz.2_Intron|MPDZ_uc011lmn.1_Intron|MPDZ_uc003zlb.3_Intron	NM_003829	NP_003820			multiple PDZ domain protein						interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)														---	---	---	---
IFNA7	3444	broad.mit.edu	37	9	21201793	21201793	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:21201793T>C	uc003zop.1	-	1	412	c.372A>G	c.(370-372)ATA>ATG	p.I124M	IFNA14_uc003zoo.1_Intron	NM_021057	NP_066401	P01567	IFNA7_HUMAN	interferon, alpha 7 precursor	124					blood coagulation|cell-cell signaling|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding				0				GBM - Glioblastoma multiforme(5;4.75e-197)|Lung(24;1.26e-23)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)														---	---	---	---
CDKN2A	1029	broad.mit.edu	37	9	21971106	21971106	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:21971106G>A	uc003zpk.2	-	2	464	c.252C>T	c.(250-252)GAC>GAT	p.D84D	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.R140C	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	84	ANK 3.		D -> E (in a bladder tumor).|D -> N (in an esophagus, a head and neck and a lung tumor).|D -> H (in non-small cell lung carcinoma).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(13)|p.D84Y(9)|p.D84V(4)|p.D84N(3)|p.D84fs*63(2)|p.D84G(2)|p.D84H(2)|p.H83fs*2(2)|p.D84_F90del(1)|p.D84D(1)|p.V82_E88del(1)|p.V82_G89>G(1)|p.D84fs*0(1)|p.E61_L94del(1)|p.D84fs*36(1)|p.R137fs*48(1)|p.A68fs*3(1)|p.P81_A85del(1)|p.R80fs*34(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)			17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			---	---	---	---
DMRTA1	63951	broad.mit.edu	37	9	22447574	22447574	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:22447574T>C	uc003zpp.1	+	1	735	c.510T>C	c.(508-510)GGT>GGC	p.G170G		NM_022160	NP_071443	Q5VZB9	DMRTA_HUMAN	DMRT-like family A1	170					cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|skin(1)	2		all_cancers(5;4.09e-243)|Acute lymphoblastic leukemia(3;8.25e-150)|all_hematologic(3;4.25e-147)|Esophageal squamous(3;2.32e-09)|Renal(3;1.71e-07)|Breast(3;2.07e-06)|Hepatocellular(5;0.00563)		GBM - Glioblastoma multiforme(1;5.12e-278)|Lung(24;8.2e-52)|LUSC - Lung squamous cell carcinoma(38;1.46e-37)|OV - Ovarian serous cystadenocarcinoma(39;0.0517)														---	---	---	---
LRRC19	64922	broad.mit.edu	37	9	26995768	26995768	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:26995768A>G	uc003zqh.2	-	5	975	c.864T>C	c.(862-864)TTT>TTC	p.F288F	IFT74_uc010mja.2_Intron|IFT74_uc010mjb.2_Intron|IFT74_uc003zqf.3_Intron|IFT74_uc003zqg.3_Intron	NM_022901	NP_075052	Q9H756	LRC19_HUMAN	leucine rich repeat containing 19 precursor	288	Helical; (Potential).					integral to membrane					0		all_neural(11;1.81e-09)		Lung(218;1.06e-05)|LUSC - Lung squamous cell carcinoma(38;0.0001)														---	---	---	---
AQP7	364	broad.mit.edu	37	9	33395068	33395068	+	Intron	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:33395068C>T	uc003zst.2	-						SUGT1P1_uc010mjq.1_Intron|AQP7_uc003zsu.1_Intron|AQP7_uc010mjs.2_5'Flank|AQP7_uc010mjt.2_Intron|AQP7_uc011lnx.1_Intron|AQP7_uc011lny.1_Intron|AQP7_uc003zss.3_Intron|AQP7_uc011lnz.1_Intron|AQP7_uc011loa.1_Intron	NM_001170	NP_001161			aquaporin 7						excretion|generation of precursor metabolites and energy	cell-cell junction|cytoplasm|integral to plasma membrane	glycerol channel activity|water channel activity				0			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.191)														---	---	---	---
KIF24	347240	broad.mit.edu	37	9	34297077	34297077	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:34297077C>T	uc003zua.3	-	4	969	c.849G>A	c.(847-849)GCG>GCA	p.A283A	KIF24_uc010mkb.2_Silent_p.A314A	NM_194313	NP_919289	Q5T7B8	KIF24_HUMAN	kinesin family member 24	283	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			central_nervous_system(1)	1			LUSC - Lung squamous cell carcinoma(29;0.0107)															---	---	---	---
KIAA1161	57462	broad.mit.edu	37	9	34371197	34371197	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:34371197G>A	uc003zue.3	-	3	1912	c.1745C>T	c.(1744-1746)GCC>GTC	p.A582V		NM_020702	NP_065753	Q6NSJ0	K1161_HUMAN	hypothetical protein LOC57462	582	Extracellular (Potential).				carbohydrate metabolic process	integral to membrane	hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(1)|breast(1)|central_nervous_system(1)	3			LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.126)														---	---	---	---
IL11RA	3590	broad.mit.edu	37	9	34658640	34658640	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:34658640G>A	uc003zvi.2	+	8	2126	c.770G>A	c.(769-771)CGT>CAT	p.R257H	IL11RA_uc011loq.1_Missense_Mutation_p.R257H|IL11RA_uc003zvj.2_Missense_Mutation_p.R257H|IL11RA_uc003zvk.2_Missense_Mutation_p.R257H|IL11RA_uc010mke.2_Missense_Mutation_p.R139H|IL11RA_uc003zvl.2_RNA	NM_004512	NP_004503	Q14626	I11RA_HUMAN	interleukin 11 receptor, alpha isoform 1	257	Extracellular (Potential).|Fibronectin type-III 2.					integral to plasma membrane	cytokine receptor activity			skin(1)	1	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.174)	Oprelvekin(DB00038)													---	---	---	---
UNC13B	10497	broad.mit.edu	37	9	35380612	35380612	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:35380612G>A	uc003zwq.2	+	17	2396	c.2104G>A	c.(2104-2106)GAG>AAG	p.E702K	UNC13B_uc003zwr.2_Missense_Mutation_p.E702K	NM_006377	NP_006368	O14795	UN13B_HUMAN	UNC13 (C. elegans)-like	702					excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			ovary(3)|large_intestine(1)|skin(1)	5	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)															---	---	---	---
UNC13B	10497	broad.mit.edu	37	9	35381108	35381108	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:35381108G>T	uc003zwq.2	+	18	2432	c.2140G>T	c.(2140-2142)GAC>TAC	p.D714Y	UNC13B_uc003zwr.2_Missense_Mutation_p.D714Y	NM_006377	NP_006368	O14795	UN13B_HUMAN	UNC13 (C. elegans)-like	714					excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			ovary(3)|large_intestine(1)|skin(1)	5	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)															---	---	---	---
C9orf100	84904	broad.mit.edu	37	9	35661184	35661184	+	3'UTR	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:35661184A>G	uc003zxm.1	-	9					C9orf100_uc003zxl.2_Intron	NM_032818	NP_116207			hypothetical protein LOC84904						regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity				0	all_epithelial(49;0.217)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)															---	---	---	---
CLTA	1211	broad.mit.edu	37	9	36199078	36199078	+	Missense_Mutation	SNP	C	T	T	rs138031703		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:36199078C>T	uc003zzc.2	+	3	520	c.358C>T	c.(358-360)CGC>TGC	p.R120C	CLTA_uc003zzd.2_Missense_Mutation_p.R120C|CLTA_uc003zze.2_Missense_Mutation_p.R120C|CLTA_uc011lpk.1_Missense_Mutation_p.R120C|CLTA_uc003zzf.1_RNA	NM_007096	NP_009027	P09496	CLCA_HUMAN	clathrin, light polypeptide A isoform b	120	Involved in binding clathrin heavy chain.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol	structural molecule activity			central_nervous_system(1)	1			STAD - Stomach adenocarcinoma(86;0.228)															---	---	---	---
GNE	10020	broad.mit.edu	37	9	36249330	36249330	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:36249330C>T	uc010mlh.2	-	2	238	c.23G>A	c.(22-24)CGA>CAA	p.R8Q	CLTA_uc003zzf.1_Intron|GNE_uc010mlg.2_Missense_Mutation_p.R8Q|GNE_uc011lpl.1_Intron|GNE_uc010mli.2_Missense_Mutation_p.R39Q|GNE_uc010mlj.2_Intron	NM_005476	NP_005467	Q9Y223	GLCNE_HUMAN	UDP-N-acetylglucosamine-2-epimerase/N-	8	UDP-N-acetylglucosamine 2-epimerase.				cell adhesion|lipopolysaccharide biosynthetic process|N-acetylneuraminate metabolic process|UDP-N-acetylglucosamine metabolic process		ATP binding|N-acylmannosamine kinase activity|UDP-N-acetylglucosamine 2-epimerase activity				0			STAD - Stomach adenocarcinoma(86;0.228)															---	---	---	---
MELK	9833	broad.mit.edu	37	9	36589562	36589562	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:36589562T>C	uc003zzn.2	+	4	312	c.174T>C	c.(172-174)ATT>ATC	p.I58I	MELK_uc011lpm.1_5'UTR|MELK_uc011lpn.1_Silent_p.I58I|MELK_uc011lpo.1_5'UTR|MELK_uc010mll.2_Silent_p.I26I|MELK_uc011lpp.1_Silent_p.I58I|MELK_uc010mlm.2_Intron|MELK_uc011lpq.1_5'UTR|MELK_uc011lpr.1_Silent_p.I58I|MELK_uc011lps.1_Silent_p.I26I	NM_014791	NP_055606	Q14680	MELK_HUMAN	maternal embryonic leucine zipper kinase	58	Protein kinase.					cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6		Acute lymphoblastic leukemia(2;1.09e-08)|all_hematologic(2;8.15e-06)	STAD - Stomach adenocarcinoma(86;0.228)															---	---	---	---
ZBTB5	9925	broad.mit.edu	37	9	37441103	37441103	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:37441103C>T	uc003zzx.2	-	2	1646	c.1446G>A	c.(1444-1446)ATG>ATA	p.M482I		NM_014872	NP_055687	O15062	ZBTB5_HUMAN	zinc finger and BTB domain containing 5	482					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(29;0.00733)|Lung(182;0.226)														---	---	---	---
ZBTB5	9925	broad.mit.edu	37	9	37441822	37441822	+	Missense_Mutation	SNP	T	C	C	rs139375543	byFrequency	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:37441822T>C	uc003zzx.2	-	2	927	c.727A>G	c.(727-729)AAT>GAT	p.N243D		NM_014872	NP_055687	O15062	ZBTB5_HUMAN	zinc finger and BTB domain containing 5	243					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(29;0.00733)|Lung(182;0.226)														---	---	---	---
EXOSC3	51010	broad.mit.edu	37	9	37784757	37784757	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:37784757G>A	uc004aal.2	-	1	311	c.285C>T	c.(283-285)AGC>AGT	p.S95S	EXOSC3_uc010mly.1_Silent_p.S95S|EXOSC3_uc004aam.2_Silent_p.S95S	NM_016042	NP_057126	Q9NQT5	EXOS3_HUMAN	exosome component 3 isoform 1	95				S -> G (in Ref. 7; AAD34097).	CUT catabolic process|DNA deamination|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|isotype switching|rRNA processing	cytoplasmic exosome (RNase complex)|cytosol|nuclear exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5'-exoribonuclease activity|protein binding|RNA binding			breast(2)	2				GBM - Glioblastoma multiforme(29;0.00771)|Lung(182;0.221)														---	---	---	---
PGM5	5239	broad.mit.edu	37	9	70993145	70993145	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:70993145A>G	uc004agr.2	+	2	521	c.292A>G	c.(292-294)ATC>GTC	p.I98V		NM_021965	NP_068800	Q15124	PGM5_HUMAN	phosphoglucomutase 5	98					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			ovary(1)|pancreas(1)	2																		---	---	---	---
APBA1	320	broad.mit.edu	37	9	72056032	72056032	+	Splice_Site	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:72056032C>A	uc004ahh.2	-	11	2458	c.2182_splice	c.e11-1	p.G728_splice		NM_001163	NP_001154			amyloid beta A4 precursor protein-binding,						axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				lung(1)	1																		---	---	---	---
PRUNE2	158471	broad.mit.edu	37	9	79318675	79318675	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:79318675G>A	uc010mpk.2	-	9	7978	c.7854C>T	c.(7852-7854)AGC>AGT	p.S2618S	PRUNE2_uc004akj.3_Silent_p.S71S|PRUNE2_uc010mpl.1_Silent_p.S71S	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	2618				S -> G (in Ref. 4; BAD93351 and 6; BAA20822).	apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0																		---	---	---	---
GNA14	9630	broad.mit.edu	37	9	80046287	80046287	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:80046287G>T	uc004aku.2	-	4	1066	c.543C>A	c.(541-543)CCC>CCA	p.P181P		NM_004297	NP_004288	O95837	GNA14_HUMAN	G alpha 14	181	GTP (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(2)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	9	82006268	82006268	+	IGR	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:82006268G>A								None (None upstream) : TLE4 (180610 downstream)																																			---	---	---	---
SLC28A3	64078	broad.mit.edu	37	9	86894278	86894278	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:86894278C>A	uc010mpz.2	-	17	1976	c.1851G>T	c.(1849-1851)GTG>GTT	p.V617V	SLC28A3_uc011lsy.1_Silent_p.V548V|SLC28A3_uc004anu.1_Silent_p.V617V	NM_022127	NP_071410	Q9HAS3	S28A3_HUMAN	concentrative Na+-nucleoside cotransporter	617	Extracellular (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|skin(1)	4																		---	---	---	---
SLC28A3	64078	broad.mit.edu	37	9	86924587	86924587	+	Silent	SNP	T	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:86924587T>G	uc010mpz.2	-	3	324	c.199A>C	c.(199-201)AGA>CGA	p.R67R	SLC28A3_uc011lsy.1_5'UTR|SLC28A3_uc004anu.1_Silent_p.R67R|SLC28A3_uc010mqb.2_5'UTR	NM_022127	NP_071410	Q9HAS3	S28A3_HUMAN	concentrative Na+-nucleoside cotransporter	67	Cytoplasmic (Potential).		R -> K.		nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|skin(1)	4																		---	---	---	---
DAPK1	1612	broad.mit.edu	37	9	90283523	90283523	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:90283523G>A	uc004apc.2	+	19	2073	c.1935G>A	c.(1933-1935)ACG>ACA	p.T645T	DAPK1_uc004apd.2_Silent_p.T645T|DAPK1_uc011ltg.1_Silent_p.T645T|DAPK1_uc011lth.1_Silent_p.T382T|DAPK1_uc004apf.1_Silent_p.T199T	NM_004938	NP_004929	P53355	DAPK1_HUMAN	death-associated protein kinase 1	645					apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			ovary(1)|breast(1)	2														Chronic_Lymphocytic_Leukemia_Familial_Clustering_of				---	---	---	---
CDK20	23552	broad.mit.edu	37	9	90589317	90589317	+	Silent	SNP	G	A	A	rs138136908		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:90589317G>A	uc004apr.2	-	1	351	c.45C>T	c.(43-45)CAC>CAT	p.H15H	CDK20_uc004aps.2_Silent_p.H15H|CDK20_uc004apt.2_Silent_p.H15H|CDK20_uc004apu.2_Silent_p.H15H	NM_001039803	NP_001034892	Q8IZL9	CDK20_HUMAN	cell cycle related kinase isoform 3	15	Protein kinase.|ATP (By similarity).				cell division|multicellular organismal development	cilium|mitochondrion|nucleus	ATP binding|cyclin-dependent protein kinase activity			skin(1)	1																		---	---	---	---
S1PR3	1903	broad.mit.edu	37	9	91617003	91617003	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:91617003C>T	uc004aqe.2	+	2	1284	c.888C>T	c.(886-888)GTC>GTT	p.V296V		NM_005226	NP_005217	Q99500	S1PR3_HUMAN	sphingosine-1-phosphate receptor 3	296	Helical; Name=7; (By similarity).				anatomical structure morphogenesis|elevation of cytosolic calcium ion concentration|inflammatory response|positive regulation of cell proliferation	integral to plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			ovary(2)|lung(1)|central_nervous_system(1)|skin(1)	5																		---	---	---	---
SEMA4D	10507	broad.mit.edu	37	9	91994223	91994223	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:91994223T>C	uc004aqo.1	-	18	2557	c.1985A>G	c.(1984-1986)CAG>CGG	p.Q662R	SEMA4D_uc011ltm.1_Intron|SEMA4D_uc011ltn.1_Intron|SEMA4D_uc011lto.1_Intron|SEMA4D_uc004aqp.1_Missense_Mutation_p.Q660R	NM_006378	NP_006369	Q92854	SEM4D_HUMAN	semaphorin 4D isoform 1	662	Extracellular (Potential).				anti-apoptosis|axon guidance|cell adhesion|immune response	integral to membrane|plasma membrane	receptor activity|receptor binding			ovary(1)|pancreas(1)	2																		---	---	---	---
NOL8	55035	broad.mit.edu	37	9	95077286	95077286	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:95077286G>T	uc004arv.2	-	7	1958	c.1621C>A	c.(1621-1623)CCT>ACT	p.P541T	NOL8_uc010mqw.2_RNA|NOL8_uc004arw.2_Intron|NOL8_uc011ltw.1_Missense_Mutation_p.P473T	NM_017948	NP_060418	Q76FK4	NOL8_HUMAN	nucleolar protein 8	541					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			ovary(1)	1																		---	---	---	---
BICD2	23299	broad.mit.edu	37	9	95482718	95482718	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:95482718G>A	uc004aso.1	-	4	983	c.926C>T	c.(925-927)GCC>GTC	p.A309V	BICD2_uc004asp.1_Missense_Mutation_p.A309V	NM_015250	NP_056065	Q8TD16	BICD2_HUMAN	bicaudal D homolog 2 isoform 2	309					microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule	cytoplasmic vesicle|cytoskeleton|Golgi apparatus|plasma membrane	Rab GTPase binding			skin(1)	1																		---	---	---	---
FGD3	89846	broad.mit.edu	37	9	95780428	95780428	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:95780428T>C	uc004asw.2	+	11	1914	c.1286T>C	c.(1285-1287)ATC>ACC	p.I429T	FGD3_uc004asx.2_Missense_Mutation_p.I429T|FGD3_uc004asz.2_Missense_Mutation_p.I429T|FGD3_uc004ata.2_Missense_Mutation_p.I232T|FGD3_uc011luc.1_Missense_Mutation_p.I32T	NM_001083536	NP_001077005	Q5JSP0	FGD3_HUMAN	FYVE, RhoGEF and PH domain containing 3	429	PH 1.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(1)|breast(1)	2																		---	---	---	---
ZNF367	195828	broad.mit.edu	37	9	99160512	99160512	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:99160512A>G	uc004awf.2	-	2	860	c.505T>C	c.(505-507)TGT>CGT	p.C169R	ZNF367_uc004awg.2_Missense_Mutation_p.C169R	NM_153695	NP_710162	Q7RTV3	ZN367_HUMAN	zinc finger protein 367	169	C2H2-type 1.				regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Acute lymphoblastic leukemia(62;0.0167)																---	---	---	---
KIAA1529	57653	broad.mit.edu	37	9	100077196	100077196	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:100077196G>A	uc011lut.1	+	20	2085	c.1312G>A	c.(1312-1314)GAA>AAA	p.E438K	KIAA1529_uc004axe.1_Missense_Mutation_p.E438K|KIAA1529_uc004axg.1_Missense_Mutation_p.E299K|KIAA1529_uc011lus.1_Missense_Mutation_p.E256K|KIAA1529_uc010msm.1_RNA|KIAA1529_uc004axf.2_Missense_Mutation_p.E299K|KIAA1529_uc011luv.1_Missense_Mutation_p.E296K	NM_020893	NP_065944			hypothetical protein LOC57653											ovary(4)|large_intestine(2)|skin(1)	7		Acute lymphoblastic leukemia(62;0.154)																---	---	---	---
NANS	54187	broad.mit.edu	37	9	100840602	100840602	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:100840602T>C	uc004ayb.2	+	5	1218	c.576T>C	c.(574-576)CCT>CCC	p.P192P	NANS_uc004ayc.2_Silent_p.P192P|TRIM14_uc004ayd.2_Intron|NANS_uc004aye.1_Silent_p.P40P	NM_018946	NP_061819	Q9NR45	SIAS_HUMAN	N-acetylneuraminic acid phosphate synthase	192					lipopolysaccharide biosynthetic process	cytoplasm	N-acetylneuraminate synthase activity|N-acylneuraminate cytidylyltransferase activity|N-acylneuraminate-9-phosphate synthase activity			skin(1)	1		Acute lymphoblastic leukemia(62;0.0559)																---	---	---	---
GRIN3A	116443	broad.mit.edu	37	9	104432579	104432579	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:104432579G>T	uc004bbp.1	-	3	2716	c.2115C>A	c.(2113-2115)CCC>CCA	p.P705P	GRIN3A_uc004bbq.1_Silent_p.P705P	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	705	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)													---	---	---	---
SLC44A1	23446	broad.mit.edu	37	9	108097858	108097858	+	Nonsense_Mutation	SNP	T	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:108097858T>A	uc004bcn.2	+	4	505	c.284T>A	c.(283-285)TTG>TAG	p.L95*	SLC44A1_uc010mtk.1_Nonsense_Mutation_p.L95*	NM_080546	NP_536856	Q8WWI5	CTL1_HUMAN	CDW92 antigen	95	Mitochondrial intermembrane (Potential).					integral to membrane|mitochondrial outer membrane|plasma membrane	choline transmembrane transporter activity			breast(3)|ovary(1)	4					Choline(DB00122)													---	---	---	---
ZNF462	58499	broad.mit.edu	37	9	109690181	109690181	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:109690181C>T	uc004bcz.2	+	3	4277	c.3988C>T	c.(3988-3990)CAT>TAT	p.H1330Y	ZNF462_uc010mto.2_Missense_Mutation_p.H1178Y|ZNF462_uc004bda.2_Missense_Mutation_p.H1178Y	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	1330					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5																		---	---	---	---
C9orf5	23731	broad.mit.edu	37	9	111853258	111853258	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:111853258A>G	uc004bdt.3	-	5	1126	c.1094T>C	c.(1093-1095)GTC>GCC	p.V365A	C9orf5_uc004bds.3_RNA|C9orf5_uc004bdr.3_Missense_Mutation_p.V365A	NM_032012	NP_114401	Q9H330	CI005_HUMAN	hypothetical protein LOC23731	365	Helical; (Potential).					integral to membrane				central_nervous_system(1)	1		Myeloproliferative disorder(63;0.204)		OV - Ovarian serous cystadenocarcinoma(323;3.08e-05)|STAD - Stomach adenocarcinoma(157;0.0823)														---	---	---	---
EPB41L4B	54566	broad.mit.edu	37	9	111956600	111956600	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:111956600G>A	uc004bdz.1	-	21	2418	c.2123C>T	c.(2122-2124)GCC>GTC	p.A708V		NM_019114	NP_061987	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	708						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|skin(1)	3																		---	---	---	---
PALM2-AKAP2	445815	broad.mit.edu	37	9	112705214	112705214	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:112705214C>T	uc004bei.2	+	7	937	c.745C>T	c.(745-747)CAC>TAC	p.H249Y	PALM2_uc004bef.2_Missense_Mutation_p.H251Y|PALM2_uc004beg.2_Missense_Mutation_p.H217Y|PALM2_uc004beh.3_Missense_Mutation_p.H249Y|PALM2-AKAP2_uc004bek.3_Intron|PALM2-AKAP2_uc004bej.3_Intron|PALM2-AKAP2_uc004bel.1_Intron	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6																		---	---	---	---
DNAJC25	548645	broad.mit.edu	37	9	114412080	114412080	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:114412080G>T	uc004bfl.2	+	3	893	c.837G>T	c.(835-837)GAG>GAT	p.E279D	DNAJC25-GNG10_uc004bfn.2_Intron|DNAJC25_uc004bfm.2_Missense_Mutation_p.E157D	NM_001015882	NP_001015882	Q9H1X3	DJC25_HUMAN	DnaJ (Hsp40) homolog, subfamily C , member 25	279					protein folding	integral to membrane	heat shock protein binding|unfolded protein binding				0																		---	---	---	---
SUSD1	64420	broad.mit.edu	37	9	114840897	114840897	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:114840897C>T	uc004bfu.2	-	12	1715	c.1674G>A	c.(1672-1674)CCG>CCA	p.P558P	SUSD1_uc010mui.2_Silent_p.P558P|SUSD1_uc010muj.2_Silent_p.P558P	NM_022486	NP_071931	Q6UWL2	SUSD1_HUMAN	sushi domain containing 1 precursor	558	Extracellular (Potential).					integral to membrane	calcium ion binding				0																		---	---	---	---
KIAA1958	158405	broad.mit.edu	37	9	115337189	115337189	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:115337189T>C	uc004bgf.1	+	2	1004	c.829T>C	c.(829-831)TCC>CCC	p.S277P	KIAA1958_uc011lwx.1_Missense_Mutation_p.S277P	NM_133465	NP_597722	Q8N8K9	K1958_HUMAN	hypothetical protein LOC158405	277										skin(1)	1																		---	---	---	---
SLC46A2	57864	broad.mit.edu	37	9	115648735	115648735	+	Intron	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:115648735C>T	uc004bgk.2	-							NM_033051	NP_149040			solute carrier family 46, member 2							integral to membrane|plasma membrane	symporter activity			central_nervous_system(1)	1																		---	---	---	---
PRPF4	9128	broad.mit.edu	37	9	116053805	116053805	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:116053805G>A	uc004bgx.2	+	14	1484	c.1434G>A	c.(1432-1434)ACG>ACA	p.T478T	PRPF4_uc004bgy.2_Silent_p.T477T	NM_004697	NP_004688	O43172	PRP4_HUMAN	PRP4 pre-mRNA processing factor 4 homolog	478	WD 6.					Cajal body|nuclear speck|spliceosomal complex|U4/U6 snRNP	protein binding			ovary(2)|pancreas(1)	3																		---	---	---	---
HDHD3	81932	broad.mit.edu	37	9	116136584	116136584	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:116136584C>T	uc004bhi.1	-	2	835	c.51G>A	c.(49-51)ACG>ACA	p.T17T	HDHD3_uc004bhj.2_Silent_p.T17T|HDHD3_uc004bhk.2_Silent_p.T17T	NM_031219	NP_112496	Q9BSH5	HDHD3_HUMAN	haloacid dehalogenase-like hydrolase domain	17							phosphoglycolate phosphatase activity|protein binding				0																		---	---	---	---
ZNF618	114991	broad.mit.edu	37	9	116812206	116812206	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:116812206A>G	uc004bid.2	+	15	2723	c.2624A>G	c.(2623-2625)TAC>TGC	p.Y875C	ZNF618_uc004bic.2_Missense_Mutation_p.Y782C|ZNF618_uc011lxi.1_Missense_Mutation_p.Y842C|ZNF618_uc011lxj.1_Missense_Mutation_p.Y843C|ZNF618_uc010mvb.2_Missense_Mutation_p.Y465C	NM_133374	NP_588615	Q5T7W0	ZN618_HUMAN	zinc finger protein 618	875					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
TRIM32	22954	broad.mit.edu	37	9	119461434	119461434	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:119461434A>G	uc004bjx.2	+	2	1571	c.1413A>G	c.(1411-1413)AAA>AAG	p.K471K	ASTN2_uc004bjr.1_Intron|ASTN2_uc004bjs.1_Intron|ASTN2_uc004bjt.1_Intron|TRIM32_uc004bjw.2_Silent_p.K471K	NM_001099679	NP_001093149	Q13049	TRI32_HUMAN	tripartite motif-containing 32	471	NHL 3.				fat cell differentiation|innate immune response|negative regulation of apoptosis|negative regulation of fibroblast proliferation|positive regulation of cell cycle|positive regulation of cell growth|positive regulation of cell migration|positive regulation of neurogenesis|positive regulation of neuron differentiation|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein catabolic process|positive regulation of proteolysis|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to tumor necrosis factor|response to UV	nucleus	myosin binding|protein self-association|RNA binding|Tat protein binding|transcription coactivator activity|translation initiation factor binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(2)|kidney(1)	3														Bardet-Biedl_syndrome				---	---	---	---
C5	727	broad.mit.edu	37	9	123737105	123737105	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:123737105T>C	uc004bkv.2	-	30	3999	c.3969A>G	c.(3967-3969)TTA>TTG	p.L1323L		NM_001735	NP_001726	P01031	CO5_HUMAN	complement component 5 preproprotein	1323					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)													---	---	---	---
C5	727	broad.mit.edu	37	9	123776151	123776151	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:123776151G>A	uc004bkv.2	-	17	2287	c.2257C>T	c.(2257-2259)CAC>TAC	p.H753Y	C5_uc010mvm.1_Missense_Mutation_p.H753Y	NM_001735	NP_001726	P01031	CO5_HUMAN	complement component 5 preproprotein	753					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)													---	---	---	---
DAB2IP	153090	broad.mit.edu	37	9	124535261	124535261	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:124535261C>T	uc004bln.2	+	12	2439	c.2370C>T	c.(2368-2370)GGC>GGT	p.G790G	DAB2IP_uc004blo.2_Silent_p.G694G|DAB2IP_uc004blp.2_Silent_p.G223G	NM_032552	NP_115941	Q5VWQ8	DAB2P_HUMAN	disabled homolog 2 interacting protein isoform	818					activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
LHX6	26468	broad.mit.edu	37	9	124979348	124979348	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:124979348G>A	uc010mvw.2	-	4	703	c.594C>T	c.(592-594)AAC>AAT	p.N198N	LHX6_uc004blx.3_Silent_p.N227N|LHX6_uc004bly.3_Silent_p.N227N	NM_014368	NP_055183	Q9UPM6	LHX6_HUMAN	LIM homeobox protein 6 isoform 1	198					cell maturation|cerebral cortex GABAergic interneuron migration|cerebral cortex radially oriented cell migration|cerebral cortex tangential migration	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0																		---	---	---	---
ZBTB26	57684	broad.mit.edu	37	9	125681320	125681320	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:125681320A>G	uc004bnj.2	-	2	1106	c.894T>C	c.(892-894)TTT>TTC	p.F298F	ZBTB26_uc004bnk.2_Silent_p.F298F	NM_020924	NP_065975	Q9HCK0	ZBT26_HUMAN	zinc finger and BTB domain containing 26	298	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
GPR21	2844	broad.mit.edu	37	9	125797676	125797676	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:125797676C>A	uc011lzk.1	+	1	831	c.831C>A	c.(829-831)TCC>TCA	p.S277S	RABGAP1_uc004bnl.3_Intron|RABGAP1_uc011lzh.1_Intron|RABGAP1_uc011lzj.1_Intron|GPR21_uc011lzi.1_RNA	NM_005294	NP_005285	Q99679	GPR21_HUMAN	G protein-coupled receptor 21	277	Extracellular (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)	1																		---	---	---	---
LHX2	9355	broad.mit.edu	37	9	126794732	126794732	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:126794732C>T	uc004boe.1	+	5	1706	c.967C>T	c.(967-969)CGC>TGC	p.R323C	LHX2_uc010mwi.1_Missense_Mutation_p.R331C	NM_004789	NP_004780	P50458	LHX2_HUMAN	LIM homeobox protein 2	323	Homeobox.|Nuclear localization signal (Potential).					nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding				0																		---	---	---	---
GARNL3	84253	broad.mit.edu	37	9	130095379	130095379	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:130095379C>A	uc011mae.1	+	9	1149	c.748C>A	c.(748-750)CGT>AGT	p.R250S	GARNL3_uc011mad.1_Missense_Mutation_p.R228S|GARNL3_uc004bqt.1_Missense_Mutation_p.R31S	NM_032293	NP_115669	Q5VVW2	GARL3_HUMAN	GTPase activating Rap/RanGAP domain-like 3	250	Rap-GAP.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			ovary(1)|central_nervous_system(1)|skin(1)	3																		---	---	---	---
NAIF1	203245	broad.mit.edu	37	9	130825856	130825856	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:130825856G>A	uc004bta.2	-	2	1054	c.835C>T	c.(835-837)CAG>TAG	p.Q279*	NAIF1_uc004bsz.2_RNA	NM_197956	NP_931045	Q69YI7	NAIF1_HUMAN	nuclear apoptosis inducing factor 1	279					apoptosis|induction of apoptosis	nucleus					0																		---	---	---	---
PTGES2	80142	broad.mit.edu	37	9	130884681	130884681	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:130884681C>T	uc004bti.2	-	6	1443	c.965G>A	c.(964-966)CGG>CAG	p.R322Q	PTGES2_uc004btj.2_RNA|PTGES2_uc004btk.2_Missense_Mutation_p.R131Q|PTGES2_uc004btl.2_Missense_Mutation_p.R131Q|PTGES2_uc004btm.2_RNA	NM_025072	NP_079348	Q9H7Z7	PGES2_HUMAN	prostaglandin E synthase 2	322	GST C-terminal.|Cytoplasmic (Potential).				cell redox homeostasis|prostaglandin biosynthetic process	Golgi membrane|integral to membrane|mitochondrion|perinuclear region of cytoplasm	electron carrier activity|prostaglandin-E synthase activity|protein binding|protein disulfide oxidoreductase activity				0																		---	---	---	---
GOLGA2	2801	broad.mit.edu	37	9	131020067	131020067	+	Splice_Site	SNP	A	G	G	rs112572208		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131020067A>G	uc011maw.1	-	23	2543	c.2530_splice	c.e23+1	p.G844_splice	GOLGA2_uc010mxw.2_Splice_Site_p.G167_splice|GOLGA2_uc004buh.2_Intron	NM_004486	NP_004477			Golgi autoantigen, golgin subfamily a, 2							Golgi cisterna membrane	protein binding			ovary(1)	1																		---	---	---	---
TOR1A	1861	broad.mit.edu	37	9	132580879	132580879	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:132580879C>A	uc004byl.2	-	4	745	c.668G>T	c.(667-669)AGG>ATG	p.R223M	TOR1A_uc004bym.2_RNA	NM_000113	NP_000104	O14656	TOR1A_HUMAN	torsin A precursor	223					chaperone mediated protein folding requiring cofactor|response to unfolded protein	endoplasmic reticulum lumen|nuclear membrane	ATP binding|serine-type endopeptidase activity|unfolded protein binding			central_nervous_system(1)	1		Ovarian(14;0.00556)																---	---	---	---
LAMC3	10319	broad.mit.edu	37	9	133911697	133911697	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:133911697C>A	uc004caa.1	+	4	1052	c.954C>A	c.(952-954)GCC>GCA	p.A318A		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	318	Laminin EGF-like 1.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)														---	---	---	---
PPAPDC3	84814	broad.mit.edu	37	9	134165682	134165682	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:134165682G>A	uc004cal.2	+	1	602	c.298G>A	c.(298-300)GCT>ACT	p.A100T		NM_032728	NP_116117	Q8NBV4	PPAC3_HUMAN	phosphatidic acid phosphatase type 2 domain	100	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear envelope	hydrolase activity			breast(1)	1	all_hematologic(7;0.0119)			OV - Ovarian serous cystadenocarcinoma(145;1.22e-05)|Epithelial(140;0.000173)														---	---	---	---
RAPGEF1	2889	broad.mit.edu	37	9	134471743	134471743	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:134471743G>A	uc004cbc.2	-	14	2203	c.2073C>T	c.(2071-2073)GAC>GAT	p.D691D	RAPGEF1_uc004cbb.2_Silent_p.D709D|RAPGEF1_uc010mzm.2_RNA|RAPGEF1_uc010mzn.2_Silent_p.D866D|RAPGEF1_uc004cbd.2_Silent_p.D696D	NM_005312	NP_005303	Q13905	RPGF1_HUMAN	guanine nucleotide-releasing factor 2 isoform a	691	N-terminal Ras-GEF.				activation of MAPKK activity|nerve growth factor receptor signaling pathway|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome	guanyl-nucleotide exchange factor activity|SH3 domain binding			lung(3)|ovary(2)|breast(1)|skin(1)	7		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.19e-05)|Epithelial(140;0.000364)														---	---	---	---
SETX	23064	broad.mit.edu	37	9	135202213	135202213	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:135202213G>T	uc004cbk.2	-	10	4955	c.4772C>A	c.(4771-4773)CCT>CAT	p.P1591H	SETX_uc004cbj.2_Missense_Mutation_p.P1210H|SETX_uc010mzt.2_Missense_Mutation_p.P1210H	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	1591					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)														---	---	---	---
SETX	23064	broad.mit.edu	37	9	135203957	135203957	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:135203957G>A	uc004cbk.2	-	10	3211	c.3028C>T	c.(3028-3030)CGT>TGT	p.R1010C	SETX_uc004cbj.2_Missense_Mutation_p.R629C|SETX_uc010mzt.2_Missense_Mutation_p.R629C	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	1010					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)														---	---	---	---
BARHL1	56751	broad.mit.edu	37	9	135462862	135462862	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:135462862G>A	uc004cbp.1	+	2	805	c.613G>A	c.(613-615)GTG>ATG	p.V205M		NM_020064	NP_064448	Q9BZE3	BARH1_HUMAN	BarH-like homeobox 1	205	Homeobox.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				OV - Ovarian serous cystadenocarcinoma(145;1.79e-06)|Epithelial(140;3.12e-05)														---	---	---	---
SARDH	1757	broad.mit.edu	37	9	136596526	136596526	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:136596526G>A	uc004cep.3	-	4	725	c.591C>T	c.(589-591)GAC>GAT	p.D197D	SARDH_uc004ceo.2_Silent_p.D197D|SARDH_uc011mdn.1_Silent_p.D197D|SARDH_uc011mdo.1_Silent_p.D29D	NM_001134707	NP_001128179	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase precursor	197					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)														---	---	---	---
COL5A1	1289	broad.mit.edu	37	9	137717721	137717721	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:137717721T>A	uc004cfe.2	+	63	5420	c.5038T>A	c.(5038-5040)TGC>AGC	p.C1680S	uc004cff.2_Intron	NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	1680	Fibrillar collagen NC1.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)														---	---	---	---
C9orf116	138162	broad.mit.edu	37	9	138387441	138387441	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:138387441C>T	uc004cft.1	-	3	307	c.243G>A	c.(241-243)TCG>TCA	p.S81S	C9orf116_uc004cfs.1_Intron|C9orf116_uc004cfu.1_Intron	NM_001048265	NP_001041730	Q5BN46	CI116_HUMAN	hypothetical protein LOC138162 isoform 1	81											0				OV - Ovarian serous cystadenocarcinoma(145;7.39e-08)|Epithelial(140;5.19e-07)|all cancers(34;1.04e-05)														---	---	---	---
OBP2A	29991	broad.mit.edu	37	9	138440623	138440623	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:138440623C>T	uc004cgb.2	+	5	500	c.458C>T	c.(457-459)TCG>TTG	p.S153L	OBP2A_uc004cgc.2_Missense_Mutation_p.R175W|OBP2A_uc010nau.2_RNA|OBP2A_uc010nav.2_Missense_Mutation_p.S130L	NM_014582	NP_055397	Q9NY56	OBP2A_HUMAN	odorant binding protein 2A precursor	153					response to stimulus|sensory perception of smell	extracellular region	odorant binding|transporter activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.39e-07)|Epithelial(140;1.11e-06)|all cancers(34;2.04e-05)														---	---	---	---
SNAPC4	6621	broad.mit.edu	37	9	139288730	139288730	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139288730C>T	uc004chh.2	-	6	612	c.603G>A	c.(601-603)CTG>CTA	p.L201L		NM_003086	NP_003077	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex,	201					snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)														---	---	---	---
NOTCH1	4851	broad.mit.edu	37	9	139395128	139395128	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139395128C>T	uc004chz.2	-	31	5810	c.5810G>A	c.(5809-5811)CGC>CAC	p.R1937H		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1937	Cytoplasmic (Potential).|ANK 1.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)				T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			---	---	---	---
NOTCH1	4851	broad.mit.edu	37	9	139412608	139412608	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139412608G>A	uc004chz.2	-	7	1236	c.1236C>T	c.(1234-1236)GAC>GAT	p.D412D		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	412	Extracellular (Potential).|EGF-like 11; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)				T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			---	---	---	---
MAMDC4	158056	broad.mit.edu	37	9	139749902	139749902	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139749902G>A	uc004cjs.2	+	12	1352	c.1302G>A	c.(1300-1302)CCG>CCA	p.P434P	MAMDC4_uc011mej.1_Intron	NM_206920	NP_996803	Q6UXC1	AEGP_HUMAN	apical early endosomal glycoprotein precursor	434	Extracellular (Potential).				protein transport	integral to membrane				breast(4)|upper_aerodigestive_tract(2)|central_nervous_system(1)	7	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)														---	---	---	---
ENTPD8	377841	broad.mit.edu	37	9	140331377	140331377	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:140331377C>T	uc004cmw.2	-	5	683	c.499G>A	c.(499-501)GCC>ACC	p.A167T	C9orf167_uc011mew.1_Intron|ENTPD8_uc004cmx.2_Missense_Mutation_p.A167T|ENTPD8_uc004cmy.2_3'UTR	NM_001033113	NP_001028285	Q5MY95	ENTP8_HUMAN	ectonucleoside triphosphate diphosphohydrolase 8	167	Extracellular (Potential).					integral to membrane|plasma membrane	ATP binding			skin(1)	1	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000224)|Epithelial(140;0.000898)														---	---	---	---
ENTPD8	377841	broad.mit.edu	37	9	140331675	140331675	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:140331675G>T	uc004cmw.2	-	4	515	c.331C>A	c.(331-333)CCA>ACA	p.P111T	C9orf167_uc011mew.1_Intron|ENTPD8_uc004cmx.2_Missense_Mutation_p.P111T|ENTPD8_uc004cmy.2_Missense_Mutation_p.P111T	NM_001033113	NP_001028285	Q5MY95	ENTP8_HUMAN	ectonucleoside triphosphate diphosphohydrolase 8	111	Extracellular (Potential).					integral to membrane|plasma membrane	ATP binding			skin(1)	1	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000224)|Epithelial(140;0.000898)														---	---	---	---
ZMYND19	116225	broad.mit.edu	37	9	140481464	140481464	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:140481464G>A	uc004cno.1	-	4	536	c.314C>T	c.(313-315)CCG>CTG	p.P105L		NM_138462	NP_612471	Q96E35	ZMY19_HUMAN	zinc finger, MYND domain containing 19	105						Golgi apparatus|plasma membrane	zinc ion binding			skin(1)	1	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000275)|Epithelial(140;0.00047)														---	---	---	---
ZMYND11	10771	broad.mit.edu	37	10	293373	293373	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:293373A>G	uc010pzt.1	+	12	1622	c.1194A>G	c.(1192-1194)GGA>GGG	p.G398G	ZMYND11_uc001ifk.2_Silent_p.G397G|ZMYND11_uc010pzu.1_Silent_p.G398G|ZMYND11_uc010pzv.1_Silent_p.G343G|ZMYND11_uc010pzw.1_Silent_p.G313G|ZMYND11_uc001ifm.2_Silent_p.G344G|ZMYND11_uc010pzx.1_Silent_p.G398G|ZMYND11_uc001ifn.2_Silent_p.G344G|ZMYND11_uc009xhg.2_Silent_p.G381G|ZMYND11_uc009xhh.2_Silent_p.G272G|ZMYND11_uc010pzy.1_Silent_p.G250G	NM_006624	NP_006615	Q15326	ZMY11_HUMAN	zinc finger, MYND domain containing 11 isoform	358	Nuclear localization signal (Potential).				cell cycle|cell proliferation|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(4;1.32e-05)|all_lung(4;3.67e-05)|Lung NSC(4;0.000301)|all_epithelial(10;0.000416)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.132)	Epithelial(11;0.00289)|all cancers(11;0.0108)|Lung(33;0.0689)|OV - Ovarian serous cystadenocarcinoma(14;0.106)														---	---	---	---
WDR37	22884	broad.mit.edu	37	10	1175291	1175291	+	3'UTR	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:1175291C>T	uc001igf.1	+	14					WDR37_uc009xhm.1_3'UTR|WDR37_uc009xhn.1_RNA|WDR37_uc001igg.1_RNA	NM_014023	NP_054742			WD repeat domain 37												0		all_epithelial(10;0.0449)|Colorectal(49;0.142)		Epithelial(11;0.134)														---	---	---	---
GDI2	2665	broad.mit.edu	37	10	5808594	5808594	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:5808594G>A	uc001iil.3	-	9	1290	c.999C>T	c.(997-999)TAC>TAT	p.Y333Y	GDI2_uc001iim.3_Silent_p.Y288Y|GDI2_uc009xid.2_Silent_p.Y337Y	NM_001494	NP_001485	P50395	GDIB_HUMAN	GDP dissociation inhibitor 2 isoform 1	333					protein transport|small GTPase mediated signal transduction	cell surface|cytosol|membrane	protein binding|Rab GDP-dissociation inhibitor activity				0																		---	---	---	---
SFMBT2	57713	broad.mit.edu	37	10	7239569	7239569	+	Silent	SNP	T	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:7239569T>G	uc009xio.1	-	15	1730	c.1639A>C	c.(1639-1641)AGG>CGG	p.R547R	SFMBT2_uc001ijn.1_Silent_p.R547R|SFMBT2_uc010qay.1_Intron	NM_001029880	NP_001025051	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	547					regulation of transcription, DNA-dependent	nucleus				ovary(4)|upper_aerodigestive_tract(2)|large_intestine(1)|central_nervous_system(1)	8																		---	---	---	---
ITIH2	3698	broad.mit.edu	37	10	7773852	7773852	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:7773852A>G	uc001ijs.2	+	13	1702	c.1540A>G	c.(1540-1542)ACT>GCT	p.T514A		NM_002216	NP_002207	P19823	ITIH2_HUMAN	inter-alpha globulin inhibitor H2 polypeptide	514					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)|pancreas(1)|skin(1)	3																		---	---	---	---
TAF3	83860	broad.mit.edu	37	10	8007477	8007477	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:8007477T>C	uc010qbd.1	+	3	2004	c.2004T>C	c.(2002-2004)CCT>CCC	p.P668P		NM_031923	NP_114129	Q5VWG9	TAF3_HUMAN	RNA polymerase II transcription factor TAFII140	668	Lys-rich.				maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			ovary(1)	1																		---	---	---	---
UPF2	26019	broad.mit.edu	37	10	12009391	12009391	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:12009391T>C	uc001ila.2	-	9	2490	c.2016A>G	c.(2014-2016)GAA>GAG	p.E672E	UPF2_uc001ilb.2_Silent_p.E672E|UPF2_uc001ilc.2_Silent_p.E672E|UPF2_uc009xiz.1_Silent_p.E672E	NM_080599	NP_542166	Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog	672	MIF4G 2.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			central_nervous_system(2)|ovary(1)	3		Renal(717;0.228)																---	---	---	---
FAM171A1	221061	broad.mit.edu	37	10	15256119	15256119	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:15256119T>C	uc001iob.2	-	8	1475	c.1468A>G	c.(1468-1470)AAC>GAC	p.N490D		NM_001010924	NP_001010924	Q5VUB5	F1711_HUMAN	hypothetical protein LOC221061 precursor	490	Cytoplasmic (Potential).					integral to membrane				ovary(2)|breast(1)|skin(1)	4																		---	---	---	---
CUBN	8029	broad.mit.edu	37	10	17113596	17113596	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:17113596C>A	uc001ioo.2	-	19	2506	c.2454G>T	c.(2452-2454)GGG>GGT	p.G818G		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	818	CUB 4.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)													---	---	---	---
GPR158	57512	broad.mit.edu	37	10	25887406	25887406	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:25887406A>G	uc001isj.2	+	11	2911	c.2851A>G	c.(2851-2853)ACA>GCA	p.T951A	GPR158_uc001isk.2_Missense_Mutation_p.T326A	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	951	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8																		---	---	---	---
APBB1IP	54518	broad.mit.edu	37	10	26789948	26789948	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:26789948A>G	uc001iss.2	+	5	682	c.361A>G	c.(361-363)ATC>GTC	p.I121V	APBB1IP_uc001isr.2_Missense_Mutation_p.I121V|APBB1IP_uc009xks.1_Missense_Mutation_p.I121V	NM_019043	NP_061916	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding,	121					blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium				lung(4)|skin(2)|central_nervous_system(1)	7																		---	---	---	---
MASTL	84930	broad.mit.edu	37	10	27453986	27453986	+	Intron	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:27453986T>C	uc001itm.2	+						MASTL_uc001itl.2_Intron|MASTL_uc009xkw.1_Intron|MASTL_uc009xkx.1_Intron	NM_032844	NP_116233			microtubule associated serine/threonine						cell division|G2/M transition of mitotic cell cycle|mitosis|negative regulation of protein phosphatase type 2A activity|regulation of cell cycle|response to DNA damage stimulus	centrosome|cleavage furrow|nucleus	ATP binding|protein phosphatase 2A binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3																		---	---	---	---
KIF5B	3799	broad.mit.edu	37	10	32306209	32306209	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:32306209T>C	uc001iwe.3	-	24	3093	c.2623A>G	c.(2623-2625)AAA>GAA	p.K875E		NM_004521	NP_004512	P33176	KINH_HUMAN	kinesin family member 5B	875					stress granule disassembly|vesicle transport along microtubule	kinesin complex|microtubule|perinuclear region of cytoplasm|vesicle	ATP binding|microtubule binding|microtubule motor activity		KIF5B/ALK(4)	lung(4)|ovary(1)	5		Prostate(175;0.0137)																---	---	---	---
NRP1	8829	broad.mit.edu	37	10	33552726	33552726	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:33552726T>C	uc001iwx.3	-	4	1029	c.506A>G	c.(505-507)AAC>AGC	p.N169S	NRP1_uc001iwv.3_Missense_Mutation_p.N169S|NRP1_uc009xlz.2_Missense_Mutation_p.N169S|NRP1_uc001iww.3_5'UTR|NRP1_uc001iwy.3_Missense_Mutation_p.N169S|NRP1_uc001iwz.2_Missense_Mutation_p.N169S|NRP1_uc001ixa.2_Missense_Mutation_p.N169S|NRP1_uc001ixb.1_Missense_Mutation_p.N169S|NRP1_uc001ixc.1_Missense_Mutation_p.N169S	NM_003873	NP_003864	O14786	NRP1_HUMAN	neuropilin 1 isoform a	169	Extracellular (Potential).|CUB 2.				axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4					Palifermin(DB00039)|Pegaptanib(DB04895)													---	---	---	---
GJD4	219770	broad.mit.edu	37	10	35896701	35896701	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:35896701T>C	uc001iyy.1	+	2	418	c.260T>C	c.(259-261)CTC>CCC	p.L87P		NM_153368	NP_699199	Q96KN9	CXD4_HUMAN	connexin40.1	87	Helical; (Potential).				cell communication	connexon complex|integral to membrane				large_intestine(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5																		---	---	---	---
C10orf25	220979	broad.mit.edu	37	10	45496198	45496198	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:45496198T>C	uc001jbv.1	-	1	139	c.110A>G	c.(109-111)AAC>AGC	p.N37S	C10orf25_uc010qff.1_RNA|ZNF22_uc001jbw.2_5'Flank	NM_001039380	NP_001034469	Q5T742	CJ025_HUMAN	hypothetical protein LOC220979 precursor	37						extracellular region					0																		---	---	---	---
ALOX5	240	broad.mit.edu	37	10	45938585	45938585	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:45938585C>T	uc001jce.2	+	10	1471	c.1372C>T	c.(1372-1374)CGG>TGG	p.R458W	ALOX5_uc009xmt.2_Missense_Mutation_p.R426W|ALOX5_uc010qfg.1_Missense_Mutation_p.R458W	NM_000698	NP_000689	P09917	LOX5_HUMAN	arachidonate 5-lipoxygenase	458	Lipoxygenase.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	cytosol|nuclear envelope lumen|nuclear matrix|nuclear membrane	arachidonate 5-lipoxygenase activity|iron ion binding|lipoxygenase activity|protein binding			ovary(1)|pancreas(1)	2		Lung SC(717;0.0257)			Diethylcarbamazine(DB00711)|Hydrocortisone(DB00741)|Leflunomide(DB01097)|Masoprocol(DB00179)|Meclofenamic acid(DB00939)|Minocycline(DB01017)|Montelukast(DB00471)|Quinacrine(DB01103)|Vitamin E(DB00163)|Zileuton(DB00744)													---	---	---	---
SYT15	83849	broad.mit.edu	37	10	46969273	46969273	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:46969273G>A	uc001jea.2	-	2	341	c.188C>T	c.(187-189)CCG>CTG	p.P63L	SYT15_uc001jdz.2_Missense_Mutation_p.P63L|SYT15_uc001jeb.2_Intron|SYT15_uc010qfp.1_5'Flank	NM_031912	NP_114118	Q9BQS2	SYT15_HUMAN	synaptotagmin XV isoform a	63	Cytoplasmic (Potential).					integral to membrane|plasma membrane					0																		---	---	---	---
FRMPD2	143162	broad.mit.edu	37	10	49414808	49414808	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:49414808C>A	uc001jgi.2	-	14	1887	c.1780G>T	c.(1780-1782)GGG>TGG	p.G594W	FRMPD2_uc001jgh.2_Missense_Mutation_p.G562W|FRMPD2_uc001jgj.2_Missense_Mutation_p.G572W	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2 isoform 3	594	FERM.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)														---	---	---	---
ERCC6	2074	broad.mit.edu	37	10	50732687	50732687	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:50732687G>A	uc001jhs.3	-	5	943	c.789C>T	c.(787-789)ATC>ATT	p.I263I	PGBD3_uc001jht.2_5'Flank|PGBD3_uc009xoe.2_Silent_p.I263I|PGBD3_uc001jhu.2_Silent_p.I263I	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent	263					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16													Direct_reversal_of_damage|NER					---	---	---	---
CISD1	55847	broad.mit.edu	37	10	60036948	60036948	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:60036948T>C	uc001jkc.3	+	2	242	c.103T>C	c.(103-105)TAT>CAT	p.Y35H		NM_018464	NP_060934	Q9NZ45	CISD1_HUMAN	CDGSH iron sulfur domain 1	35	Cytoplasmic (Potential).					integral to membrane|mitochondrial outer membrane	2 iron, 2 sulfur cluster binding|metal ion binding				0																		---	---	---	---
ANK3	288	broad.mit.edu	37	10	61827769	61827769	+	Splice_Site	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:61827769T>C	uc001jky.2	-	38	12437	c.12245_splice	c.e38-1	p.G4082_splice	ANK3_uc001jkw.2_Splice_Site_p.S603_splice|ANK3_uc009xpa.2_Splice_Site_p.S603_splice|ANK3_uc001jkx.2_Splice_Site_p.S647_splice|ANK3_uc010qih.1_Splice_Site_p.S1470_splice|ANK3_uc001jkz.3_Splice_Site_p.S1463_splice|ANK3_uc001jkv.2_Splice_Site_p.S2_splice|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267			ankyrin 3 isoform 1						establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19																		---	---	---	---
EGR2	1959	broad.mit.edu	37	10	64573620	64573620	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:64573620G>A	uc010qim.1	-	3	932	c.778C>T	c.(778-780)CCT>TCT	p.P260S	EGR2_uc010qin.1_Missense_Mutation_p.P210S|EGR2_uc001jmi.2_Missense_Mutation_p.P260S|EGR2_uc010qio.1_Missense_Mutation_p.P273S|EGR2_uc009xph.2_Missense_Mutation_p.P260S	NM_001136177	NP_001129649	P11161	EGR2_HUMAN	early growth response 2 protein isoform a	260					fat cell differentiation|protein export from nucleus|transcription from RNA polymerase II promoter	cytoplasm|nucleus	chromatin binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			ovary(2)	2	Prostate(12;0.0297)|all_hematologic(501;0.228)																	---	---	---	---
CTNNA3	29119	broad.mit.edu	37	10	67829230	67829230	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:67829230C>A	uc009xpn.1	-	15	2118	c.1995G>T	c.(1993-1995)CTG>CTT	p.L665L	CTNNA3_uc001jmw.2_Silent_p.L665L	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	665					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8																		---	---	---	---
CCAR1	55749	broad.mit.edu	37	10	70509441	70509441	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:70509441T>C	uc001joo.2	+	10	1236	c.1117T>C	c.(1117-1119)TGT>CGT	p.C373R	CCAR1_uc001jol.1_RNA|CCAR1_uc001jom.1_Missense_Mutation_p.C178R|CCAR1_uc009xpx.1_Missense_Mutation_p.C347R|CCAR1_uc001jon.1_Missense_Mutation_p.C319R|CCAR1_uc010qiz.1_Missense_Mutation_p.C358R|CCAR1_uc010qja.1_Missense_Mutation_p.C358R|CCAR1_uc010qjb.1_RNA	NM_018237	NP_060707	Q8IX12	CCAR1_HUMAN	cell-cycle and apoptosis regulatory protein 1	373					apoptosis|cell cycle|nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm|perinuclear region of cytoplasm	calcium ion binding|nucleic acid binding|protein binding			ovary(6)|large_intestine(1)	7																		---	---	---	---
KIAA1279	26128	broad.mit.edu	37	10	70768669	70768669	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:70768669G>A	uc001joy.2	+	5	958	c.862G>A	c.(862-864)GCC>ACC	p.A288T		NM_015634	NP_056449	Q96EK5	KBP_HUMAN	KIF1 binding protein	288					cell differentiation|mitochondrial transport|nervous system development	mitochondrion	kinesin binding			ovary(1)	1																		---	---	---	---
HKDC1	80201	broad.mit.edu	37	10	71026488	71026488	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:71026488T>C	uc001jpf.3	+	18	2862	c.2729T>C	c.(2728-2730)TTA>TCA	p.L910S	HKDC1_uc010qje.1_Missense_Mutation_p.L773S|HKDC1_uc009xqb.2_RNA	NM_025130	NP_079406	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	910					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			ovary(4)|skin(1)	5																		---	---	---	---
CDH23	64072	broad.mit.edu	37	10	73405660	73405660	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:73405660G>A	uc001jrx.3	+	12	1590	c.1213G>A	c.(1213-1215)GTC>ATC	p.V405I	CDH23_uc001jrw.3_Missense_Mutation_p.V405I|CDH23_uc001jry.2_Missense_Mutation_p.V21I|CDH23_uc001jrz.2_Missense_Mutation_p.V21I	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	405	Cadherin 4.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11																		---	---	---	---
CDH23	64072	broad.mit.edu	37	10	73491866	73491866	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:73491866A>G	uc001jrx.3	+	31	4215	c.3838A>G	c.(3838-3840)ATG>GTG	p.M1280V	CDH23_uc001jrz.2_Missense_Mutation_p.M896V|C10orf105_uc001jsb.1_Intron|CDH23_uc001jsc.1_Missense_Mutation_p.M88V	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	1280	Cadherin 12.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11																		---	---	---	---
CDH23	64072	broad.mit.edu	37	10	73571099	73571099	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:73571099G>A	uc001jrx.3	+	61	9482	c.9105G>A	c.(9103-9105)AAG>AAA	p.K3035K	CDH23_uc001jsg.3_Silent_p.K795K|CDH23_uc001jsh.3_Silent_p.K795K|CDH23_uc001jsi.3_Silent_p.K795K|CDH23_uc001jsj.3_5'Flank|CDH23_uc010qjr.1_5'Flank	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	3035	Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11																		---	---	---	---
OIT3	170392	broad.mit.edu	37	10	74684031	74684031	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:74684031A>G	uc001jte.1	+	7	1214	c.996A>G	c.(994-996)CTA>CTG	p.L332L	OIT3_uc009xqs.1_Intron	NM_152635	NP_689848	Q8WWZ8	OIT3_HUMAN	oncoprotein-induced transcript 3 precursor	332	ZP.					nuclear envelope	calcium ion binding			ovary(2)	2	Prostate(51;0.0198)																	---	---	---	---
USP54	159195	broad.mit.edu	37	10	75279629	75279629	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:75279629C>T	uc001juo.2	-	17	2621	c.2604G>A	c.(2602-2604)CAG>CAA	p.Q868Q	USP54_uc010qkk.1_Silent_p.Q50Q|USP54_uc001juk.2_Intron|USP54_uc001jul.2_Intron|USP54_uc001jum.2_Intron|USP54_uc001jun.2_Intron|USP54_uc001jup.2_Silent_p.Q868Q	NM_152586	NP_689799	Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	868	Poly-Gln.				ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(3)|lung(2)|kidney(1)	6	Prostate(51;0.0112)																	---	---	---	---
SYNPO2L	79933	broad.mit.edu	37	10	75407636	75407636	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:75407636C>T	uc001jut.3	-	4	1926	c.1774G>A	c.(1774-1776)GCG>ACG	p.A592T	SYNPO2L_uc001jus.3_Missense_Mutation_p.A368T	NM_001114133	NP_001107605	Q9H987	SYP2L_HUMAN	synaptopodin 2-like isoform a	592	Pro-rich.					cytoplasm|cytoskeleton	actin binding			ovary(1)	1	Prostate(51;0.0112)																	---	---	---	---
POLR3A	11128	broad.mit.edu	37	10	79761979	79761979	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:79761979T>C	uc001jzn.2	-	17	2429	c.2335A>G	c.(2335-2337)ACC>GCC	p.T779A		NM_007055	NP_008986	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	779					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding				0	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)															---	---	---	---
GRID1	2894	broad.mit.edu	37	10	87484209	87484209	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:87484209T>C	uc001kdl.1	-	11	1859	c.1758A>G	c.(1756-1758)ATA>ATG	p.I586M	GRID1_uc009xsu.1_RNA|GRID1_uc010qmf.1_Missense_Mutation_p.I157M	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	586	Cytoplasmic (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)										Multiple Myeloma(13;0.14)			---	---	---	---
GLUD1	2746	broad.mit.edu	37	10	88820800	88820800	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:88820800T>C	uc001keh.2	-	7	1028	c.931A>G	c.(931-933)AAT>GAT	p.N311D	GLUD1_uc001keg.2_Missense_Mutation_p.N144D|GLUD1_uc010qmp.1_Missense_Mutation_p.N178D	NM_005271	NP_005262	P00367	DHE3_HUMAN	glutamate dehydrogenase 1 precursor	311					glutamate biosynthetic process|glutamate catabolic process|positive regulation of insulin secretion	mitochondrial matrix	ADP binding|ATP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|identical protein binding|leucine binding|NAD+ binding				0					L-Glutamic Acid(DB00142)|NADH(DB00157)													---	---	---	---
RNLS	55328	broad.mit.edu	37	10	90342950	90342950	+	5'UTR	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:90342950C>T	uc001kfe.2	-	1					RNLS_uc010qms.1_5'UTR|RNLS_uc001kfd.2_5'UTR	NM_001031709	NP_001026879			renalase isoform 1							extracellular region	oxidoreductase activity			ovary(1)	1																OREG0020353	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
STAMBPL1	57559	broad.mit.edu	37	10	90665321	90665321	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:90665321A>G	uc001kfk.2	+	3	575	c.152A>G	c.(151-153)TAC>TGC	p.Y51C	STAMBPL1_uc010qmx.1_Missense_Mutation_p.Y51C|STAMBPL1_uc009xto.2_RNA|STAMBPL1_uc001kfl.2_Missense_Mutation_p.Y51C|STAMBPL1_uc001kfm.2_5'Flank	NM_020799	NP_065850	Q96FJ0	STALP_HUMAN	STAM binding protein-like 1	51							metal ion binding|metallopeptidase activity|protein binding			ovary(1)	1		Colorectal(252;0.0381)		Colorectal(12;6.38e-05)|COAD - Colon adenocarcinoma(12;7.75e-05)														---	---	---	---
IFIT3	3437	broad.mit.edu	37	10	91099808	91099808	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:91099808G>T	uc001kgf.2	+	2	1625	c.1396G>T	c.(1396-1398)GGT>TGT	p.G466C	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron|uc001kgd.2_Intron|IFIT3_uc001kgg.2_Missense_Mutation_p.G466C	NM_001549	NP_001540	O14879	IFIT3_HUMAN	interferon-induced protein with	466	TPR 8.				type I interferon-mediated signaling pathway		protein binding			central_nervous_system(1)	1																		---	---	---	---
KIF11	3832	broad.mit.edu	37	10	94373230	94373230	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:94373230G>T	uc001kic.2	+	8	1194	c.886G>T	c.(886-888)GGA>TGA	p.G296*	KIF11_uc010qnq.1_Intron	NM_004523	NP_004514	P52732	KIF11_HUMAN	kinesin family member 11	296	Kinesin-motor.				blood coagulation|cell division|microtubule-based movement|spindle assembly involved in mitosis	chromatin remodeling complex|cytosol|kinesin complex|microtubule|spindle pole	ATP binding|microtubule motor activity|protein kinase binding			skin(1)	1																		---	---	---	---
NOC3L	64318	broad.mit.edu	37	10	96117944	96117944	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:96117944T>C	uc001kjq.1	-	3	334	c.246A>G	c.(244-246)GAA>GAG	p.E82E	NOC3L_uc009xuk.1_5'UTR	NM_022451	NP_071896	Q8WTT2	NOC3L_HUMAN	nucleolar complex associated 3 homolog	82						nuclear speck|nucleolus	binding			ovary(1)	1		Colorectal(252;0.0897)																---	---	---	---
CYP2C19	1557	broad.mit.edu	37	10	96541727	96541727	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:96541727T>C	uc010qnz.1	+	5	792	c.792T>C	c.(790-792)ATT>ATC	p.I264I	CYP2C19_uc009xus.1_Silent_p.I129I|CYP2C19_uc010qny.1_Silent_p.I242I	NM_000769	NP_000760	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C,	264					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)													---	---	---	---
TM9SF3	56889	broad.mit.edu	37	10	98292872	98292872	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:98292872A>G	uc001kmm.3	-	10	1478	c.1261T>C	c.(1261-1263)TCA>CCA	p.S421P	TM9SF3_uc010qot.1_Missense_Mutation_p.S421P	NM_020123	NP_064508	Q9HD45	TM9S3_HUMAN	transmembrane 9 superfamily member 3 precursor	421						integral to membrane	binding				0		Colorectal(252;0.158)		Epithelial(162;1.84e-09)|all cancers(201;2.84e-08)														---	---	---	---
PYROXD2	84795	broad.mit.edu	37	10	100167414	100167414	+	Splice_Site	SNP	T	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:100167414T>G	uc001kpc.2	-	4	328	c.242_splice	c.e4-1	p.G81_splice	PYROXD2_uc001kpb.2_Splice_Site|PYROXD2_uc001kpd.2_Splice_Site|PYROXD2_uc010qpe.1_Splice_Site_p.G81_splice	NM_032709	NP_116098			pyridine nucleotide-disulphide oxidoreductase								oxidoreductase activity			central_nervous_system(1)	1																		---	---	---	---
CPN1	1369	broad.mit.edu	37	10	101841235	101841235	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:101841235T>G	uc001kql.2	-	1	408	c.148A>C	c.(148-150)AGC>CGC	p.S50R		NM_001308	NP_001299	P15169	CBPN_HUMAN	carboxypeptidase N, polypeptide 1 precursor	50	Catalytic.				proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(3)|pancreas(1)	4		Colorectal(252;0.234)		Epithelial(162;4.77e-10)|all cancers(201;3.82e-08)														---	---	---	---
GBF1	8729	broad.mit.edu	37	10	104117861	104117861	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:104117861G>A	uc001kux.1	+	9	945	c.705G>A	c.(703-705)CGG>CGA	p.R235R	GBF1_uc001kuw.2_Silent_p.R235R|GBF1_uc001kuy.1_Silent_p.R235R|GBF1_uc001kuz.1_Silent_p.R235R	NM_004193	NP_004184	Q92538	GBF1_HUMAN	golgi-specific brefeldin A resistant guanine	235					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)														---	---	---	---
NT5C2	22978	broad.mit.edu	37	10	104860806	104860806	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:104860806T>C	uc001kwo.2	-	8	721	c.535A>G	c.(535-537)ACC>GCC	p.T179A	NT5C2_uc010qqp.1_Missense_Mutation_p.T150A|NT5C2_uc001kwq.2_Missense_Mutation_p.T179A|NT5C2_uc001kwp.2_Translation_Start_Site	NM_012229	NP_036361	P49902	5NTC_HUMAN	5'-nucleotidase, cytosolic II	179					purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|metal ion binding|nucleotide binding|protein binding				0		all_hematologic(284;0.176)|Colorectal(252;0.178)		Epithelial(162;1.33e-08)|all cancers(201;1.04e-07)|BRCA - Breast invasive adenocarcinoma(275;0.159)	Adenosine triphosphate(DB00171)|Ribavirin(DB00811)													---	---	---	---
PDCD11	22984	broad.mit.edu	37	10	105200346	105200346	+	Intron	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:105200346C>T	uc001kwy.1	+							NM_014976	NP_055791			programmed cell death 11						mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)														---	---	---	---
SMC3	9126	broad.mit.edu	37	10	112333461	112333461	+	Intron	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:112333461C>T	uc001kze.2	+							NM_005445	NP_005436			structural maintenance of chromosomes 3						cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)														---	---	---	---
NHLRC2	374354	broad.mit.edu	37	10	115639427	115639427	+	Silent	SNP	A	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:115639427A>T	uc001lax.1	+	4	1094	c.882A>T	c.(880-882)GCA>GCT	p.A294A		NM_198514	NP_940916	Q8NBF2	NHLC2_HUMAN	NHL repeat containing 2	294	NHL 2.				cell redox homeostasis					ovary(1)	1				Epithelial(162;0.017)|all cancers(201;0.0187)														---	---	---	---
ATRNL1	26033	broad.mit.edu	37	10	116881571	116881571	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:116881571A>G	uc001lcg.2	+	3	872	c.486A>G	c.(484-486)GTA>GTG	p.V162V	ATRNL1_uc001lce.2_RNA|ATRNL1_uc001lcf.2_Silent_p.V162V|ATRNL1_uc009xyq.2_Silent_p.V162V	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	162	CUB.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)														---	---	---	---
KCNK18	338567	broad.mit.edu	37	10	118960795	118960795	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:118960795G>A	uc010qsr.1	+	2	349	c.349G>A	c.(349-351)GTG>ATG	p.V117M		NM_181840	NP_862823	Q7Z418	KCNKI_HUMAN	potassium channel, subfamily K, member 18	117						integral to membrane|plasma membrane				upper_aerodigestive_tract(1)	1		Colorectal(252;0.19)		all cancers(201;0.0211)														---	---	---	---
INPP5F	22876	broad.mit.edu	37	10	121587268	121587268	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:121587268C>T	uc001leo.2	+	20	3541	c.3375C>T	c.(3373-3375)TGC>TGT	p.C1125C	INPP5F_uc001lep.2_Silent_p.C515C	NM_014937	NP_055752	Q9Y2H2	SAC2_HUMAN	inositol polyphosphate-5-phosphatase F	1125							phosphoric ester hydrolase activity			ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)														---	---	---	---
FGFR2	2263	broad.mit.edu	37	10	123274742	123274742	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:123274742C>A	uc010qtk.1	-	9	1823	c.1176G>T	c.(1174-1176)GTG>GTT	p.V392V	FGFR2_uc010qtg.1_Silent_p.V280V|FGFR2_uc010qth.1_Silent_p.V277V|FGFR2_uc010qti.1_Silent_p.V303V|FGFR2_uc010qtj.1_Silent_p.V393V|FGFR2_uc010qtl.1_Intron|FGFR2_uc010qtm.1_Silent_p.V277V|FGFR2_uc001lfl.3_Silent_p.V393V|FGFR2_uc001lfm.2_Silent_p.V304V|FGFR2_uc001lfn.3_RNA|FGFR2_uc001lfg.3_Silent_p.V2V	NM_000141	NP_000132	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2 isoform 1	392	Helical; (Potential).				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding	p.V392A(1)		endometrium(44)|skin(28)|lung(11)|ovary(4)|cervix(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|soft_tissue(1)|central_nervous_system(1)	96		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)		5	Mis		gastric. NSCLC|endometrial		Crouzon|Pfeiffer|and Apert syndromes		Apert_syndrome|Saethre-Chotzen_syndrome				---	---	---	---
TACC2	10579	broad.mit.edu	37	10	123971212	123971212	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:123971212G>A	uc001lfv.2	+	9	7632	c.7272G>A	c.(7270-7272)ACG>ACA	p.T2424T	TACC2_uc001lfw.2_Silent_p.T570T|TACC2_uc009xzx.2_Silent_p.T2379T|TACC2_uc010qtv.1_Silent_p.T2428T|TACC2_uc001lfx.2_Silent_p.T128T|TACC2_uc001lfy.2_Silent_p.T128T|TACC2_uc001lfz.2_Silent_p.T502T|TACC2_uc001lga.2_Silent_p.T502T|TACC2_uc009xzy.2_Silent_p.T502T|TACC2_uc001lgb.2_Silent_p.T459T|TACC2_uc010qtw.1_Silent_p.T519T	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	2424						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)																---	---	---	---
LHPP	64077	broad.mit.edu	37	10	126172753	126172753	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:126172753G>A	uc001lhs.1	+	2	191	c.171G>A	c.(169-171)TCG>TCA	p.S57S	LHPP_uc001lht.1_Silent_p.S57S|LHPP_uc009yai.1_Silent_p.S57S	NM_022126	NP_071409	Q9H008	LHPP_HUMAN	phospholysine phosphohistidine inorganic	57					protein dephosphorylation	cytosol|nucleus	inorganic diphosphatase activity|magnesium ion binding|phosphohistidine phosphatase activity|protein homodimerization activity				0		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.163)|Colorectal(40;0.187)														---	---	---	---
CTBP2	1488	broad.mit.edu	37	10	126683183	126683183	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:126683183T>C	uc009yak.2	-	7	922	c.635A>G	c.(634-636)TAC>TGC	p.Y212C	CTBP2_uc009yal.2_Missense_Mutation_p.Y212C|CTBP2_uc001lif.3_Missense_Mutation_p.Y212C|CTBP2_uc001lih.3_Missense_Mutation_p.Y212C|CTBP2_uc001lid.3_Missense_Mutation_p.Y280C|CTBP2_uc001lie.3_Missense_Mutation_p.Y752C	NM_001329	NP_001320	P56545	CTBP2_HUMAN	C-terminal binding protein 2 isoform 1	212					negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent|viral genome replication|white fat cell differentiation	cell junction|synapse|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding				0		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.173)		Colorectal(40;0.00572)|COAD - Colon adenocarcinoma(40;0.0127)|GBM - Glioblastoma multiforme(135;0.147)														---	---	---	---
UROS	7390	broad.mit.edu	37	10	127504804	127504804	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:127504804G>A	uc001liw.3	-	2	222	c.89C>T	c.(88-90)GCC>GTC	p.A30V	UROS_uc001liv.3_5'Flank|UROS_uc010quh.1_RNA|UROS_uc001lix.3_Missense_Mutation_p.A30V|UROS_uc001liy.3_RNA|UROS_uc001liz.2_5'Flank	NM_000375	NP_000366	P10746	HEM4_HUMAN	uroporphyrinogen III synthase	30					heme biosynthetic process|uroporphyrinogen III biosynthetic process	cytosol|mitochondrion	uroporphyrinogen-III synthase activity				0		all_lung(145;0.00756)|Lung NSC(174;0.0116)|Colorectal(57;0.0855)|all_neural(114;0.0937)|Breast(234;0.203)																---	---	---	---
BNIP3	664	broad.mit.edu	37	10	133784230	133784230	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:133784230T>C	uc001lkv.1	-	5	577	c.451A>G	c.(451-453)ATG>GTG	p.M151V	BNIP3_uc001lku.1_5'Flank|BNIP3_uc010qut.1_Missense_Mutation_p.M151V	NM_004052	NP_004043	Q12983	BNIP3_HUMAN	BCL2/adenovirus E1B 19kD-interacting protein 3	151					cellular response to cobalt ion|cellular response to hypoxia|cellular response to mechanical stimulus|chromatin remodeling|defense response to virus|DNA fragmentation involved in apoptotic nuclear change|induction of apoptosis|interspecies interaction between organisms|mitochondrial fragmentation involved in apoptosis|negative regulation of membrane potential|negative regulation of mitochondrial fusion|negative regulation of survival gene product expression|neuron apoptosis|positive regulation of mitochondrial fission|positive regulation of protein complex disassembly|positive regulation of release of cytochrome c from mitochondria|reactive oxygen species metabolic process|regulation of mitochondrial membrane permeability	dendrite|integral to mitochondrial outer membrane|nuclear envelope|nucleoplasm	GTPase binding|protein heterodimerization activity|protein homodimerization activity			lung(1)|skin(1)	2		all_cancers(35;4e-11)|all_epithelial(44;5.07e-08)|Ovarian(717;2.61e-05)|Lung NSC(174;0.00237)|all_lung(145;0.00354)|Breast(234;0.023)|all_neural(114;0.0299)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)		Epithelial(32;1.59e-12)|all cancers(32;3.75e-11)|OV - Ovarian serous cystadenocarcinoma(35;2.57e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)														---	---	---	---
C10orf91	170393	broad.mit.edu	37	10	134261301	134261301	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:134261301A>G	uc001llm.2	+	3	214	c.174A>G	c.(172-174)AAA>AAG	p.K58K		NM_173541	NP_775812	Q5T1B1	CJ091_HUMAN	hypothetical protein LOC170393	58										ovary(1)	1		all_cancers(35;6.69e-12)|all_epithelial(44;1.55e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)|all_hematologic(284;0.224)		OV - Ovarian serous cystadenocarcinoma(35;6.95e-05)|Epithelial(32;0.000142)|all cancers(32;0.000162)														---	---	---	---
ADAM8	101	broad.mit.edu	37	10	135083930	135083930	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:135083930C>T	uc010qva.1	-	15	1653	c.1602G>A	c.(1600-1602)GCG>GCA	p.A534A	ADAM8_uc010quz.1_Silent_p.A573A|ADAM8_uc009ybi.2_Silent_p.A573A			P78325	ADAM8_HUMAN	SubName: Full=cDNA FLJ50704, highly similar to ADAM 8 (EC 3.4.24.-) (A disintegrinand metalloproteinase domain 8);	534					integrin-mediated signaling pathway|proteolysis		metalloendopeptidase activity			large_intestine(2)|central_nervous_system(1)	3		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;7.72e-06)|OV - Ovarian serous cystadenocarcinoma(35;8.23e-06)|Epithelial(32;1.02e-05)														---	---	---	---
TUBGCP2	10844	broad.mit.edu	37	10	135106172	135106172	+	Missense_Mutation	SNP	C	T	T	rs145003131		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:135106172C>T	uc001lmg.1	-	8	1402	c.1045G>A	c.(1045-1047)GAA>AAA	p.E349K	TUBGCP2_uc001lmf.1_5'Flank|TUBGCP2_uc010qvc.1_Missense_Mutation_p.E377K|TUBGCP2_uc009ybk.1_Missense_Mutation_p.E349K|TUBGCP2_uc010qvd.1_Missense_Mutation_p.E219K|TUBGCP2_uc001lmh.1_RNA	NM_006659	NP_006650	Q9BSJ2	GCP2_HUMAN	tubulin, gamma complex associated protein 2	349					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytoplasmic microtubule|cytosol|spindle pole	protein binding				0		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.87e-06)|all cancers(32;8.98e-06)|Epithelial(32;1.15e-05)														---	---	---	---
LRDD	55367	broad.mit.edu	37	11	802043	802043	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:802043G>A	uc001lro.1	-	7	1366	c.1224C>T	c.(1222-1224)TGC>TGT	p.C408C	LRDD_uc009yck.1_RNA|LRDD_uc001lrk.1_Silent_p.C408C|LRDD_uc001lrl.1_Silent_p.C262C|LRDD_uc001lrm.1_Silent_p.C95C|LRDD_uc001lrn.1_Silent_p.C262C|LRDD_uc001lrp.1_5'UTR	NM_145886	NP_665893	Q9HB75	PIDD_HUMAN	leucine rich repeat and death domain containing	408	ZU5 1.				apoptosis|signal transduction	cytoplasm|nucleus	death receptor binding				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)														---	---	---	---
AP2A2	161	broad.mit.edu	37	11	959505	959505	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:959505G>T	uc001lss.2	+	2	317	c.136G>T	c.(136-138)GGT>TGT	p.G46C	AP2A2_uc001lst.1_Missense_Mutation_p.G46C|AP2A2_uc009yco.1_RNA	NM_012305	NP_036437	O94973	AP2A2_HUMAN	adaptor-related protein complex 2, alpha 2	46	Lipid-binding.				axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|cytosol	lipid binding|protein transporter activity				0		all_cancers(49;9.46e-06)|Breast(177;0.00257)|all_epithelial(84;0.0027)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.75e-24)|BRCA - Breast invasive adenocarcinoma(625;5.73e-05)|Lung(200;0.0696)|LUSC - Lung squamous cell carcinoma(625;0.082)														---	---	---	---
LOC338651	338651	broad.mit.edu	37	11	1619234	1619234	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:1619234C>A	uc009ycx.1	+	2	1085	c.334C>A	c.(334-336)CCC>ACC	p.P112T	LOC338651_uc001ltt.1_RNA|KRTAP5-2_uc001ltv.2_Missense_Mutation_p.G83C	NR_021489				SubName: Full=cDNA FLJ30579 fis, clone BRAWH2006989, weakly similar to DNA-DIRECTED RNA POLYMERASE II LARGEST SUBUNIT;          EC=2.7.7.6;												0																		---	---	---	---
SYT8	90019	broad.mit.edu	37	11	1858627	1858627	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:1858627G>A	uc001lue.1	+	9	1300	c.1172G>A	c.(1171-1173)CGC>CAC	p.R391H	SYT8_uc001lud.2_Missense_Mutation_p.R391H|SYT8_uc001luf.1_Missense_Mutation_p.R377H|TNNI2_uc010qxc.1_5'Flank|TNNI2_uc010qxd.1_5'Flank|TNNI2_uc010qxe.1_5'Flank	NM_138567	NP_612634	Q8NBV8	SYT8_HUMAN	synaptotagmin VIII	391	Cytoplasmic (Potential).					acrosomal vesicle|integral to membrane|plasma membrane|synaptic vesicle	transporter activity			ovary(1)	1		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)														---	---	---	---
TH	7054	broad.mit.edu	37	11	2192945	2192945	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:2192945C>T	uc001lvq.2	-	1	91	c.72G>A	c.(70-72)AAG>AAA	p.K24K	TH_uc001lvp.2_Silent_p.K24K|TH_uc001lvr.2_Silent_p.K24K|TH_uc010qxj.1_Silent_p.K24K|TH_uc001lvs.2_Silent_p.K24K|TH_uc001lvt.2_Silent_p.K24K	NM_199292	NP_954986	P07101	TY3H_HUMAN	tyrosine hydroxylase isoform a	24					dopamine biosynthetic process from tyrosine|embryonic camera-type eye morphogenesis|epinephrine biosynthetic process|eye photoreceptor cell development|heart morphogenesis|hormone biosynthetic process|learning|locomotory behavior|memory|neurotransmitter biosynthetic process|neurotransmitter secretion|norepinephrine biosynthetic process|pigmentation|regulation of heart contraction|response to ethanol|response to hypoxia|synaptic transmission, dopaminergic|visual perception	cytosol|internal side of plasma membrane|melanosome membrane|nucleus|perikaryon|smooth endoplasmic reticulum	protein binding|tyrosine 3-monooxygenase activity				0		all_epithelial(84;1.46e-23)|Lung NSC(207;4.44e-11)|all_lung(207;1.11e-09)|Ovarian(85;1.78e-06)|Breast(177;1.78e-05)|Medulloblastoma(188;0.0208)|all_neural(188;0.0416)	Colorectal(5;0.00245)|COAD - Colon adenocarcinoma(6;0.0239)	BRCA - Breast invasive adenocarcinoma(625;8.45e-09)|Lung(200;0.000152)|LUSC - Lung squamous cell carcinoma(625;0.00154)	L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Metyrosine(DB00765)|Tetrahydrobiopterin(DB00360)													---	---	---	---
OSBPL5	114879	broad.mit.edu	37	11	3141754	3141754	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:3141754G>A	uc001lxk.2	-	6	661	c.503C>T	c.(502-504)ACG>ATG	p.T168M	OSBPL5_uc010qxq.1_Intron|OSBPL5_uc009ydw.2_Intron|OSBPL5_uc001lxl.2_Intron|OSBPL5_uc009ydx.2_Missense_Mutation_p.T192M	NM_020896	NP_065947	Q9H0X9	OSBL5_HUMAN	oxysterol-binding protein-like protein 5 isoform	168	PH.				cholesterol metabolic process|cholesterol transport|Golgi to plasma membrane transport	cytosol	oxysterol binding|protein binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)														---	---	---	---
ZNF195	7748	broad.mit.edu	37	11	3380779	3380779	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:3380779T>C	uc001lxt.2	-	6	1637	c.1459A>G	c.(1459-1461)ACT>GCT	p.T487A	uc001lxr.2_5'Flank|ZNF195_uc001lxv.2_Missense_Mutation_p.T464A|ZNF195_uc001lxs.2_Missense_Mutation_p.T415A|ZNF195_uc010qxr.1_Missense_Mutation_p.T468A|ZNF195_uc009ydz.2_Missense_Mutation_p.T442A|ZNF195_uc001lxu.2_Missense_Mutation_p.T419A	NM_001130520	NP_001123992	O14628	ZN195_HUMAN	zinc finger protein 195 isoform 1	487	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Medulloblastoma(188;0.00106)|Breast(177;0.00328)|all_neural(188;0.00681)|Ovarian(85;0.00965)		BRCA - Breast invasive adenocarcinoma(625;0.0361)|LUSC - Lung squamous cell carcinoma(625;0.2)														---	---	---	---
OR51B2	79345	broad.mit.edu	37	11	5345074	5345074	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:5345074C>T	uc001mao.1	-	1	509	c.454G>A	c.(454-456)GTA>ATA	p.V152I	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron	NM_033180	NP_149420	Q9Y5P1	O51B2_HUMAN	olfactory receptor, family 51, subfamily B,	152	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)														---	---	---	---
OR51I1	390063	broad.mit.edu	37	11	5462728	5462728	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:5462728C>T	uc010qze.1	-	1	17	c.17G>A	c.(16-18)GGC>GAC	p.G6D	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001005288	NP_001005288	Q9H343	O51I1_HUMAN	olfactory receptor, family 51, subfamily I,	6	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)														---	---	---	---
TRIM34	53840	broad.mit.edu	37	11	5662423	5662423	+	Intron	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:5662423C>T	uc001mbh.2	+						HBG2_uc001mak.1_Intron|TRIM6-TRIM34_uc001mbf.2_Intron|TRIM34_uc009yeq.2_Intron|TRIM34_uc001mbi.2_Intron|TRIM34_uc001mbj.2_Silent_p.C259C|TRIM78P_uc009yer.2_5'Flank	NM_001003827	NP_001003827			tripartite motif protein 34 isoform 1						protein trimerization	cytoplasm	zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;5.72e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)														---	---	---	---
APBB1	322	broad.mit.edu	37	11	6432080	6432080	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:6432080A>T	uc001mdb.1	-	2	598	c.498T>A	c.(496-498)GAT>GAA	p.D166E	APBB1_uc001mdc.1_Missense_Mutation_p.D166E|APBB1_uc010rah.1_Intron	NM_001164	NP_001155	O00213	APBB1_HUMAN	amyloid beta A4 precursor protein-binding,	166	Glu-rich.				apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding			breast(2)	2		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)														---	---	---	---
OR2AG2	338755	broad.mit.edu	37	11	6789258	6789258	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:6789258G>A	uc001meq.1	-	1	931	c.931C>T	c.(931-933)CTG>TTG	p.L311L		NM_001004490	NP_001004490	A6NM03	O2AG2_HUMAN	olfactory receptor, family 2, subfamily AG,	311	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)		Epithelial(150;2.15e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)														---	---	---	---
OLFML1	283298	broad.mit.edu	37	11	7531212	7531212	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:7531212G>T	uc001mfi.2	+	3	1354	c.1002G>T	c.(1000-1002)GGG>GGT	p.G334G	OLFML1_uc010raz.1_Silent_p.G198G|OLFML1_uc010rba.1_Silent_p.G334G	NM_198474	NP_940876	Q6UWY5	OLFL1_HUMAN	olfactomedin-like 1 precursor	334	Olfactomedin-like.					extracellular region				ovary(2)	2				Epithelial(150;6.96e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)														---	---	---	---
CYB5R2	51700	broad.mit.edu	37	11	7687700	7687700	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:7687700G>T	uc001mfm.2	-	8	878	c.640C>A	c.(640-642)CTG>ATG	p.L214M	CYB5R2_uc001mfn.2_RNA|CYB5R2_uc009yfk.2_Missense_Mutation_p.L214M	NM_016229	NP_057313	Q6BCY4	NB5R2_HUMAN	cytochrome b5 reductase b5R.2	214					sterol biosynthetic process	membrane|soluble fraction	cytochrome-b5 reductase activity				0				Epithelial(150;5.48e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)												OREG0020724	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
RPL27A	6157	broad.mit.edu	37	11	8705792	8705792	+	Intron	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:8705792C>A	uc001mgs.3	+						SNORA3_uc001mgq.1_RNA|SNORA45_uc001mgr.1_5'Flank	NM_000990	NP_000981			ribosomal protein L27a						endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0				Epithelial(150;3.24e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)														---	---	---	---
SCUBE2	57758	broad.mit.edu	37	11	9096091	9096091	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:9096091A>G	uc001mhh.1	-	4	534	c.454T>C	c.(454-456)TGC>CGC	p.C152R	SCUBE2_uc001mhi.1_Missense_Mutation_p.C152R|SCUBE2_uc001mhj.1_Missense_Mutation_p.C152R	NM_020974	NP_066025	Q9NQ36	SCUB2_HUMAN	CEGP1 protein precursor	152	EGF-like 3; calcium-binding (Potential).					extracellular region	calcium ion binding			ovary(1)|skin(1)	2				all cancers(16;8.57e-09)|Epithelial(150;4.42e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0116)														---	---	---	---
ZNF143	7702	broad.mit.edu	37	11	9530309	9530309	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:9530309A>G	uc001mhr.2	+	12	1409	c.1291A>G	c.(1291-1293)ACG>GCG	p.T431A	ZNF143_uc009yfu.2_Missense_Mutation_p.T430A|ZNF143_uc010rby.1_Missense_Mutation_p.T400A	NM_003442	NP_003433	P52747	ZN143_HUMAN	zinc finger protein 143	431	C2H2-type 7.				regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding|zinc ion binding				0				all cancers(16;4.12e-09)|Epithelial(150;2.29e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0212)														---	---	---	---
FAR1	84188	broad.mit.edu	37	11	13732384	13732384	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:13732384G>A	uc001mld.2	+	5	845	c.690G>A	c.(688-690)TCG>TCA	p.S230S	FAR1_uc009ygp.2_Silent_p.S230S	NM_032228	NP_115604	Q8WVX9	FACR1_HUMAN	fatty acyl CoA reductase 1	230					ether lipid biosynthetic process	integral to membrane|peroxisomal matrix|peroxisomal membrane	protein binding			ovary(1)|skin(1)	2																		---	---	---	---
FAR1	84188	broad.mit.edu	37	11	13750296	13750296	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:13750296G>T	uc001mld.2	+	12	1678	c.1523G>T	c.(1522-1524)CGA>CTA	p.R508L		NM_032228	NP_115604	Q8WVX9	FACR1_HUMAN	fatty acyl CoA reductase 1	508					ether lipid biosynthetic process	integral to membrane|peroxisomal matrix|peroxisomal membrane	protein binding			ovary(1)|skin(1)	2																		---	---	---	---
MRGPRX3	117195	broad.mit.edu	37	11	18159005	18159005	+	Missense_Mutation	SNP	C	T	T	rs141255495		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:18159005C>T	uc001mnu.2	+	3	617	c.256C>T	c.(256-258)CGC>TGC	p.R86C		NM_054031	NP_473372	Q96LB0	MRGX3_HUMAN	MAS-related GPR, member X3	86	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|pancreas(1)	2																		---	---	---	---
SLC6A5	9152	broad.mit.edu	37	11	20622906	20622906	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:20622906T>C	uc001mqd.2	+	2	508	c.235T>C	c.(235-237)TCT>CCT	p.S79P	SLC6A5_uc009yic.2_5'UTR	NM_004211	NP_004202	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter	79	Cytoplasmic (Potential).				synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(2)|breast(1)|skin(1)	4					Glycine(DB00145)													---	---	---	---
LUZP2	338645	broad.mit.edu	37	11	24518834	24518834	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:24518834G>A	uc001mqs.2	+	1	279	c.45G>A	c.(43-45)GCG>GCA	p.A15A	LUZP2_uc009yif.2_5'UTR|LUZP2_uc009yig.2_Silent_p.A15A	NM_001009909	NP_001009909	Q86TE4	LUZP2_HUMAN	leucine zipper protein 2 precursor	15						extracellular region				ovary(1)|skin(1)	2																		---	---	---	---
BDNF	627	broad.mit.edu	37	11	27679694	27679694	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:27679694C>T	uc010rdu.1	-	2	1269	c.418G>A	c.(418-420)GTG>ATG	p.V140M	BDNFOS_uc001mrm.2_Intron|BDNFOS_uc009yij.2_Intron|BDNFOS_uc009yik.2_Intron|BDNFOS_uc009yil.2_Intron|BDNFOS_uc001mrp.2_Intron|BDNFOS_uc009yim.2_Intron|BDNFOS_uc009yin.2_Intron|BDNFOS_uc009yio.2_Intron|BDNFOS_uc009yip.2_Intron|BDNFOS_uc001mrn.2_Intron|BDNFOS_uc009yiq.2_Intron|BDNFOS_uc001mro.2_Intron|BDNFOS_uc009yir.2_Intron|BDNFOS_uc009yis.2_Intron|BDNFOS_uc009yit.2_Intron|BDNFOS_uc009yiu.2_Intron|BDNFOS_uc009yiv.2_Intron|BDNFOS_uc009yiw.2_Intron|BDNFOS_uc009yix.2_Intron|BDNFOS_uc009yiy.2_Intron|BDNFOS_uc009yiz.2_Intron|BDNFOS_uc001mrq.3_Intron|BDNFOS_uc001mrr.3_Intron|BDNFOS_uc009yja.2_Intron|BDNFOS_uc009yjb.2_Intron|BDNF_uc010rdv.1_Missense_Mutation_p.V140M|BDNF_uc001mrt.2_Missense_Mutation_p.V155M|BDNF_uc010rdw.1_Missense_Mutation_p.V140M|BDNF_uc009yjd.2_Missense_Mutation_p.V140M|BDNF_uc001mru.2_Missense_Mutation_p.V140M|BDNF_uc010rdx.1_Missense_Mutation_p.V140M|BDNF_uc010rdy.1_Missense_Mutation_p.V140M|BDNF_uc009yjg.2_Missense_Mutation_p.V140M|BDNF_uc009yje.2_Missense_Mutation_p.V222M|BDNF_uc009yjf.2_Missense_Mutation_p.V169M|BDNF_uc001mrv.2_Missense_Mutation_p.V140M|BDNF_uc001mrw.3_Missense_Mutation_p.V140M|BDNF_uc001mrx.2_Missense_Mutation_p.V140M|BDNF_uc001mry.3_Missense_Mutation_p.V140M|BDNF_uc001mrz.3_Missense_Mutation_p.V140M|BDNF_uc001msa.2_Missense_Mutation_p.V148M	NM_001143816	NP_001137288	P23560	BDNF_HUMAN	brain-derived neurotrophic factor isoform a	140						extracellular region	growth factor activity				0																		---	---	---	---
HIPK3	10114	broad.mit.edu	37	11	33309063	33309063	+	Intron	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:33309063T>C	uc001mul.1	+						HIPK3_uc001mum.1_Intron|HIPK3_uc009yjv.1_Intron	NM_005734	NP_005725			homeodomain interacting protein kinase 3 isoform						anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)|skin(1)|stomach(1)|ovary(1)|pancreas(1)	5																		---	---	---	---
ABTB2	25841	broad.mit.edu	37	11	34192448	34192448	+	Intron	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:34192448C>T	uc001mvl.1	-							NM_145804	NP_665803			ankyrin repeat and BTB (POZ) domain containing								DNA binding			central_nervous_system(1)|skin(1)	2		Acute lymphoblastic leukemia(5;0.0508)|all_hematologic(20;0.0691)																---	---	---	---
CAT	847	broad.mit.edu	37	11	34470818	34470818	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:34470818C>A	uc001mvm.2	+	2	229	c.146C>A	c.(145-147)CCC>CAC	p.P49H	CAT_uc009ykc.1_RNA	NM_001752	NP_001743	P04040	CATA_HUMAN	catalase	49					hydrogen peroxide catabolic process|negative regulation of apoptosis|positive regulation of cell division|protein tetramerization|purine base metabolic process|purine nucleotide catabolic process|UV protection	peroxisomal matrix|peroxisomal membrane	catalase activity|heme binding|NADP binding|protein homodimerization activity			ovary(2)|pancreas(1)	3		Lung NSC(402;2.76e-08)|Acute lymphoblastic leukemia(5;0.00143)|all_hematologic(20;0.0116)|Melanoma(852;0.027)		BRCA - Breast invasive adenocarcinoma(625;0.000995)	Fomepizole(DB01213)													---	---	---	---
RAG2	5897	broad.mit.edu	37	11	36615184	36615184	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:36615184G>T	uc001mwv.3	-	2	723	c.535C>A	c.(535-537)CTG>ATG	p.L179M	C11orf74_uc010rfd.1_5'Flank|C11orf74_uc001mww.1_5'Flank|C11orf74_uc001mwx.1_5'Flank|C11orf74_uc001mwy.1_5'Flank|C11orf74_uc001mwz.1_5'Flank|C11orf74_uc010rfe.1_5'Flank	NM_000536	NP_000527	P55895	RAG2_HUMAN	recombination activating gene 2	179					chromatin modification|pre-B cell allelic exclusion|somatic diversification of immunoglobulins|T cell differentiation in thymus|V(D)J recombination	nucleus	chromatin binding|DNA binding|endonuclease activity|methylated histone residue binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|zinc ion binding			skin(3)|ovary(1)|pancreas(1)	5	all_lung(20;0.226)	all_hematologic(20;0.00756)												Familial_Hemophagocytic_Lymphohistiocytosis				---	---	---	---
CREB3L1	90993	broad.mit.edu	37	11	46338915	46338915	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:46338915G>A	uc001ncf.2	+	10	1570	c.1135G>A	c.(1135-1137)GCA>ACA	p.A379T	CREB3L1_uc001ncg.2_Missense_Mutation_p.A13T	NM_052854	NP_443086	Q96BA8	CR3L1_HUMAN	cAMP responsive element binding protein 3-like	379	Helical; Signal-anchor for type II membrane protein; (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L1(6)	soft_tissue(6)|ovary(2)	8				GBM - Glioblastoma multiforme(35;0.0285)				T	FUS	myxofibrosarcoma								---	---	---	---
LRP4	4038	broad.mit.edu	37	11	46917831	46917831	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:46917831C>A	uc001ndn.3	-	9	1124	c.978G>T	c.(976-978)GGG>GGT	p.G326G		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	326	Extracellular (Potential).|LDL-receptor class A 8.				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)														---	---	---	---
MYBPC3	4607	broad.mit.edu	37	11	47353733	47353733	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:47353733A>G	uc001nfa.3	-	32	3759	c.3704T>C	c.(3703-3705)GTG>GCG	p.V1235A		NM_000256	NP_000247	Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	1234	Ig-like C2-type 7.				cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			ovary(2)|central_nervous_system(1)	3				Lung(87;0.176)														---	---	---	---
NUP160	23279	broad.mit.edu	37	11	47828692	47828692	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:47828692C>A	uc001ngm.2	-	19	2461	c.2376G>T	c.(2374-2376)CTG>CTT	p.L792L	NUP160_uc009ylw.2_RNA	NM_015231	NP_056046	Q12769	NU160_HUMAN	nucleoporin 160kDa	792					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7																		---	---	---	---
FOLH1	2346	broad.mit.edu	37	11	49208219	49208219	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:49208219C>T	uc001ngy.2	-	5	877	c.616G>A	c.(616-618)GGG>AGG	p.G206R	FOLH1_uc001ngz.2_Missense_Mutation_p.G206R|FOLH1_uc009yly.2_Missense_Mutation_p.G191R|FOLH1_uc009ylz.2_Missense_Mutation_p.G191R|FOLH1_uc009yma.2_5'UTR	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	206	Extracellular (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)													---	---	---	---
TRIM48	79097	broad.mit.edu	37	11	55035854	55035854	+	Intron	SNP	T	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55035854T>A	uc010rid.1	+							NM_024114	NP_077019			tripartite motif-containing 48							intracellular	zinc ion binding				0																		---	---	---	---
TRIM48	79097	broad.mit.edu	37	11	55035855	55035855	+	Intron	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55035855A>G	uc010rid.1	+							NM_024114	NP_077019			tripartite motif-containing 48							intracellular	zinc ion binding				0																		---	---	---	---
OR4S2	219431	broad.mit.edu	37	11	55418630	55418630	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55418630T>C	uc001nhs.1	+	1	251	c.251T>C	c.(250-252)TTA>TCA	p.L84S		NM_001004059	NP_001004059	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S,	84	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.0748)																---	---	---	---
OR5M9	390162	broad.mit.edu	37	11	56230509	56230509	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:56230509G>A	uc010rjj.1	-	1	369	c.369C>T	c.(367-369)GCC>GCT	p.A123A		NM_001004743	NP_001004743	Q8NGP3	OR5M9_HUMAN	olfactory receptor, family 5, subfamily M,	123	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)																	---	---	---	---
APLNR	187	broad.mit.edu	37	11	57003943	57003943	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:57003943A>G	uc001njo.2	-	1	985	c.536T>C	c.(535-537)GTG>GCG	p.V179A	APLNR_uc001njn.3_RNA	NM_005161	NP_005152	P35414	APJ_HUMAN	apelin receptor	179	Extracellular (Potential).					integral to plasma membrane	G-protein coupled receptor activity			lung(5)|ovary(1)	6																		---	---	---	---
MED19	219541	broad.mit.edu	37	11	57472438	57472438	+	Intron	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:57472438G>A	uc001nla.1	-						MED19_uc001nlb.2_Intron	NM_153450	NP_703151			mediator complex subunit 19						regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(2)	2																		---	---	---	---
OR10Q1	219960	broad.mit.edu	37	11	57995687	57995687	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:57995687C>T	uc010rkd.1	-	1	661	c.661G>A	c.(661-663)GTC>ATC	p.V221I		NM_001004471	NP_001004471	Q8NGQ4	O10Q1_HUMAN	olfactory receptor, family 10, subfamily Q,	221	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Breast(21;0.0589)																---	---	---	---
CNTF	1270	broad.mit.edu	37	11	58391580	58391580	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:58391580A>G	uc001nna.3	+	2	268	c.188A>G	c.(187-189)CAG>CGG	p.Q63R	ZFP91-CNTF_uc010rkm.1_RNA	NM_000614	NP_000605	P26441	CNTF_HUMAN	ciliary neurotrophic factor	63					ciliary neurotrophic factor-mediated signaling pathway|growth|negative regulation of neuron apoptosis|positive regulation of tyrosine phosphorylation of Stat3 protein		ciliary neurotrophic factor receptor binding|growth factor activity|interleukin-6 receptor binding			ovary(1)	1		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)																---	---	---	---
CD6	923	broad.mit.edu	37	11	60777101	60777101	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:60777101T>A	uc001nqq.2	+	5	1062	c.839T>A	c.(838-840)GTA>GAA	p.V280E	CD6_uc009yni.2_Intron|CD6_uc009ynj.2_Intron|CD6_uc001nqp.2_Missense_Mutation_p.V280E|CD6_uc001nqr.2_Missense_Mutation_p.V280E|CD6_uc001nqs.2_RNA|CD6_uc001nqt.2_Missense_Mutation_p.V280E	NM_006725	NP_006716	P30203	CD6_HUMAN	CD6 molecule precursor	280	SRCR 3.|Extracellular (Potential).				cell adhesion	cell surface|integral to plasma membrane	scavenger receptor activity			pancreas(1)	1																		---	---	---	---
CD5	921	broad.mit.edu	37	11	60885876	60885876	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:60885876C>T	uc009ynk.2	+	3	427	c.324C>T	c.(322-324)TAC>TAT	p.Y108Y		NM_014207	NP_055022	P06127	CD5_HUMAN	CD5 molecule precursor	108	Extracellular (Potential).|SRCR 1.				cell proliferation|cell recognition	integral to plasma membrane	scavenger receptor activity			ovary(1)	1		all_lung(304;5.94e-05)|Lung NSC(402;7.26e-05)		BRCA - Breast invasive adenocarcinoma(625;0.000946)|Lung(977;0.0086)|LUSC - Lung squamous cell carcinoma(625;0.0528)														---	---	---	---
DAGLA	747	broad.mit.edu	37	11	61490373	61490373	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:61490373T>C	uc001nsa.2	+	4	461	c.350T>C	c.(349-351)GTC>GCC	p.V117A		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	neural stem cell-derived dendrite regulator	117	Helical; (Potential).				cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3				READ - Rectum adenocarcinoma(4;0.219)														---	---	---	---
FADS2	9415	broad.mit.edu	37	11	61632650	61632650	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:61632650A>G	uc001nsl.1	+	11	1334	c.1184A>G	c.(1183-1185)AAC>AGC	p.N395S	FADS2_uc001nsj.2_Missense_Mutation_p.N373S|FADS2_uc010rlo.1_Missense_Mutation_p.N364S	NM_004265	NP_004256	O95864	FADS2_HUMAN	fatty acid desaturase 2	395	Cytoplasmic (Potential).				electron transport chain|transport|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	heme binding			ovary(1)|pancreas(1)	2					Alpha-Linolenic Acid(DB00132)													---	---	---	---
INCENP	3619	broad.mit.edu	37	11	61908215	61908215	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:61908215C>T	uc001nsw.1	+	9	1585	c.1383C>T	c.(1381-1383)GAC>GAT	p.D461D	INCENP_uc009ynw.1_Silent_p.D461D|INCENP_uc001nsx.1_Silent_p.D461D	NM_001040694	NP_001035784	Q9NQS7	INCE_HUMAN	inner centromere protein antigens 135/155kDa	461					chromosome segregation|cytokinesis|mitotic prometaphase	centromeric heterochromatin|condensed chromosome kinetochore|cytosol|microtubule|spindle	protein binding			lung(1)	1																		---	---	---	---
AHNAK	79026	broad.mit.edu	37	11	62301479	62301479	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62301479T>C	uc001ntl.2	-	5	710	c.410A>G	c.(409-411)GAT>GGT	p.D137G	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	137					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)																---	---	---	---
RARRES3	5920	broad.mit.edu	37	11	63312165	63312165	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:63312165G>A	uc001nxf.3	+	3	259	c.191G>A	c.(190-192)CGC>CAC	p.R64H		NM_004585	NP_004576	Q9UL19	TIG3_HUMAN	retinoic acid receptor responder (tazarotene	64					lipid catabolic process|negative regulation of cell proliferation		hydrolase activity			ovary(1)	1																		---	---	---	---
NRXN2	9379	broad.mit.edu	37	11	64419631	64419631	+	Intron	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:64419631G>A	uc001oar.2	-						NRXN2_uc001oas.2_Intron|NRXN2_uc001oaq.2_Intron	NM_015080	NP_055895			neurexin 2 isoform alpha-1 precursor						cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10																		---	---	---	---
PYGM	5837	broad.mit.edu	37	11	64527327	64527327	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:64527327C>T	uc001oax.3	-	1	861	c.44G>A	c.(43-45)AGT>AAT	p.S15N	PYGM_uc001oay.3_Missense_Mutation_p.S15N	NM_005609	NP_005600	P11217	PYGM_HUMAN	muscle glycogen phosphorylase isoform 1	15					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			ovary(2)	2					Pyridoxal Phosphate(DB00114)													---	---	---	---
CAPN1	823	broad.mit.edu	37	11	64972271	64972271	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:64972271G>A	uc009yqd.1	+	11	1394	c.1283G>A	c.(1282-1284)CGT>CAT	p.R428H	CAPN1_uc001odf.1_Missense_Mutation_p.R428H|CAPN1_uc001odg.1_Missense_Mutation_p.R428H|CAPN1_uc010roa.1_Missense_Mutation_p.R169H	NM_005186	NP_005177	P07384	CAN1_HUMAN	calpain 1, large subunit	428	Domain III.				positive regulation of cell proliferation|proteolysis	cytoplasm|plasma membrane	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|protein binding			ovary(1)	1		Lung NSC(402;0.094)|Melanoma(852;0.16)		Lung(977;0.00168)|LUSC - Lung squamous cell carcinoma(976;0.00813)												OREG0021073	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
FRMD8	83786	broad.mit.edu	37	11	65172535	65172535	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65172535G>T	uc001odu.3	+	10	1464	c.1272G>T	c.(1270-1272)GAG>GAT	p.E424D	FRMD8_uc009yqj.2_Missense_Mutation_p.E368D|FRMD8_uc010rof.1_Missense_Mutation_p.E390D	NM_031904	NP_114110	Q9BZ67	FRMD8_HUMAN	FERM domain containing 8	424						cytoskeleton	binding			lung(1)|pancreas(1)	2																		---	---	---	---
SCYL1	57410	broad.mit.edu	37	11	65293830	65293830	+	Intron	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65293830C>T	uc001oea.1	+						SCYL1_uc009yqk.2_Intron|SCYL1_uc001oeb.1_Intron|SCYL1_uc001oec.1_Intron|SCYL1_uc001oed.1_Intron	NM_020680	NP_065731			SCY1-like 1 isoform A						regulation of transcription, DNA-dependent|retrograde vesicle-mediated transport, Golgi to ER|transcription, DNA-dependent	cis-Golgi network|COPI vesicle coat|ER-Golgi intermediate compartment|microtubule organizing center|nucleus	ATP binding|DNA binding|protein tyrosine kinase activity			skin(1)	1																		---	---	---	---
SCYL1	57410	broad.mit.edu	37	11	65298114	65298114	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65298114C>T	uc001oea.1	+	7	941	c.864C>T	c.(862-864)GCC>GCT	p.A288A	SCYL1_uc009yqk.2_Silent_p.A288A|SCYL1_uc001oeb.1_Silent_p.A288A|SCYL1_uc001oec.1_Silent_p.A288A|SCYL1_uc001oed.1_Silent_p.A145A|SCYL1_uc001oee.1_5'UTR	NM_020680	NP_065731	Q96KG9	NTKL_HUMAN	SCY1-like 1 isoform A	288	Protein kinase.				regulation of transcription, DNA-dependent|retrograde vesicle-mediated transport, Golgi to ER|transcription, DNA-dependent	cis-Golgi network|COPI vesicle coat|ER-Golgi intermediate compartment|microtubule organizing center|nucleus	ATP binding|DNA binding|protein tyrosine kinase activity			skin(1)	1																		---	---	---	---
DKFZp761E198	91056	broad.mit.edu	37	11	65546733	65546733	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65546733C>T	uc001ofo.3	-	1	1090	c.1060G>A	c.(1060-1062)GCC>ACC	p.A354T		NM_138368	NP_612377	Q2VPB7	YK046_HUMAN	hypothetical protein LOC91056	354	Leu-rich.						protein binding				0				READ - Rectum adenocarcinoma(159;0.167)														---	---	---	---
SART1	9092	broad.mit.edu	37	11	65729303	65729303	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65729303G>A	uc001ogl.2	+	1	144	c.52G>A	c.(52-54)GCG>ACG	p.A18T	SART1_uc009yqy.1_Missense_Mutation_p.A18T|SART1_uc010rot.1_5'UTR	NM_005146	NP_005137	O43290	SNUT1_HUMAN	squamous cell carcinoma antigen recognized by T	18					cell cycle arrest|induction of apoptosis by intracellular signals|positive regulation of cytotoxic T cell differentiation|spliceosomal snRNP assembly	Cajal body|catalytic step 2 spliceosome|cytosol				ovary(1)	1																		---	---	---	---
SART1	9092	broad.mit.edu	37	11	65746378	65746378	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65746378A>G	uc001ogl.2	+	19	2469	c.2377A>G	c.(2377-2379)ATG>GTG	p.M793V		NM_005146	NP_005137	O43290	SNUT1_HUMAN	squamous cell carcinoma antigen recognized by T	793					cell cycle arrest|induction of apoptosis by intracellular signals|positive regulation of cytotoxic T cell differentiation|spliceosomal snRNP assembly	Cajal body|catalytic step 2 spliceosome|cytosol				ovary(1)	1																		---	---	---	---
CATSPER1	117144	broad.mit.edu	37	11	65788382	65788382	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65788382G>A	uc001ogt.2	-	6	1965	c.1827C>T	c.(1825-1827)GAC>GAT	p.D609D		NM_053054	NP_444282	Q8NEC5	CTSR1_HUMAN	sperm-associated cation channel 1	609	Extracellular (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			ovary(2)	2																		---	---	---	---
CD248	57124	broad.mit.edu	37	11	66084371	66084371	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66084371G>T	uc001ohm.1	-	1	145	c.128C>A	c.(127-129)ACC>AAC	p.T43N		NM_020404	NP_065137	Q9HCU0	CD248_HUMAN	tumor endothelial marker 1 precursor	43	C-type lectin.|Extracellular (Potential).					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			large_intestine(3)	3					Cefalotin(DB00456)													---	---	---	---
SLC29A2	3177	broad.mit.edu	37	11	66136862	66136862	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66136862G>T	uc001oht.2	-	3	482	c.253C>A	c.(253-255)CTC>ATC	p.L85I	SLC29A2_uc001ohs.2_5'UTR|SLC29A2_uc010rpb.1_RNA|SLC29A2_uc009yrf.2_5'UTR|SLC29A2_uc001ohu.2_Missense_Mutation_p.L85I|SLC29A2_uc001ohv.2_Missense_Mutation_p.L85I|uc001ohw.1_RNA	NM_001532	NP_001523	Q14542	S29A2_HUMAN	solute carrier family 29 (nucleoside	85	Helical; (Potential).				cell proliferation|nucleobase, nucleoside and nucleotide metabolic process	basolateral plasma membrane|integral to plasma membrane|nuclear membrane|nucleolus	nucleoside transmembrane transporter activity			ovary(1)	1																		---	---	---	---
SPTBN2	6712	broad.mit.edu	37	11	66472378	66472378	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66472378C>T	uc001ojd.2	-	14	2441	c.2369G>A	c.(2368-2370)CGG>CAG	p.R790Q		NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	790	Spectrin 5.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4																		---	---	---	---
C11orf80	79703	broad.mit.edu	37	11	66581352	66581352	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66581352C>A	uc001ojf.2	+	10	1062	c.1055C>A	c.(1054-1056)CCT>CAT	p.P352H	C11orf80_uc001ojg.2_Missense_Mutation_p.P119H|C11orf80_uc001ojh.2_Missense_Mutation_p.P120H|C11orf80_uc001oji.2_Missense_Mutation_p.P120H|C11orf80_uc010rpl.1_5'UTR|C11orf80_uc001ojj.2_5'UTR	NM_024650	NP_078926	Q8N6T0	CK080_HUMAN	hypothetical protein LOC79703	197											0																		---	---	---	---
RHOD	29984	broad.mit.edu	37	11	66833381	66833381	+	Silent	SNP	G	A	A	rs147100013		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66833381G>A	uc001ojv.2	+	2	232	c.147G>A	c.(145-147)ACG>ACA	p.T49T		NM_014578	NP_055393	O00212	RHOD_HUMAN	ras homolog D precursor	49	Effector region (Potential).				regulation of small GTPase mediated signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity				0																		---	---	---	---
ADRBK1	156	broad.mit.edu	37	11	67046979	67046979	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:67046979G>A	uc009yrn.1	+	4	621	c.355G>A	c.(355-357)GCC>ACC	p.A119T	ADRBK1_uc009yrm.1_Missense_Mutation_p.A119T	NM_001619	NP_001610	P25098	ARBK1_HUMAN	beta-adrenergic receptor kinase 1	119	RGS.|N-terminal.				activation of phospholipase C activity|cardiac muscle contraction|desensitization of G-protein coupled receptor protein signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of striated muscle contraction|negative regulation of the force of heart contraction by chemical signal|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of catecholamine secretion|tachykinin receptor signaling pathway	cytosol|soluble fraction	alpha-2A adrenergic receptor binding|ATP binding|beta-adrenergic receptor kinase activity|Edg-2 lysophosphatidic acid receptor binding|G-protein coupled receptor kinase activity|signal transducer activity			large_intestine(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)		Adenosine triphosphate(DB00171)													---	---	---	---
TCIRG1	10312	broad.mit.edu	37	11	67816415	67816415	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:67816415G>A	uc001one.2	+	14	1732	c.1624G>A	c.(1624-1626)GGC>AGC	p.G542S	TCIRG1_uc001ong.2_Missense_Mutation_p.G326S|TCIRG1_uc001onh.2_Missense_Mutation_p.G244S|TCIRG1_uc001oni.2_Missense_Mutation_p.G46S|TCIRG1_uc009ysd.2_5'Flank	NM_006019	NP_006010	Q13488	VPP3_HUMAN	T-cell, immune regulator 1 isoform a	542	Helical; (Potential).				ATP hydrolysis coupled proton transport|cellular defense response|cellular iron ion homeostasis|insulin receptor signaling pathway|positive regulation of cell proliferation|transferrin transport	apical plasma membrane|endosome membrane|integral to plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity			ovary(1)	1																		---	---	---	---
CPT1A	1374	broad.mit.edu	37	11	68548161	68548161	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:68548161G>T	uc001oog.3	-	12	1575	c.1405C>A	c.(1405-1407)CTC>ATC	p.L469I	CPT1A_uc001oof.3_Missense_Mutation_p.L469I|CPT1A_uc009ysj.2_Intron	NM_001876	NP_001867	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A liver isoform	469	Cytoplasmic (Potential).				carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			skin(2)	2	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)													---	---	---	---
ANO1	55107	broad.mit.edu	37	11	69957855	69957855	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:69957855A>G	uc001opj.2	+	7	1147	c.842A>G	c.(841-843)TAC>TGC	p.Y281C	ANO1_uc001opk.1_Missense_Mutation_p.Y253C|ANO1_uc001opl.1_RNA|ANO1_uc010rqk.1_Missense_Mutation_p.Y16C	NM_018043	NP_060513	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	281	Cytoplasmic (Potential).				multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			ovary(1)|pancreas(1)	2																		---	---	---	---
ANO1	55107	broad.mit.edu	37	11	70028653	70028653	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:70028653T>C	uc001opj.2	+	24	2754	c.2449T>C	c.(2449-2451)TAC>CAC	p.Y817H	ANO1_uc001opl.1_RNA|ANO1_uc010rqk.1_Missense_Mutation_p.Y526H|ANO1_uc010rql.1_5'UTR	NM_018043	NP_060513	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	817	Extracellular (Potential).				multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			ovary(1)|pancreas(1)	2																		---	---	---	---
KRTAP5-8	57830	broad.mit.edu	37	11	71249264	71249264	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:71249264G>T	uc001oqr.1	+	1	194	c.163G>T	c.(163-165)GGC>TGC	p.G55C		NM_021046	NP_066384	O75690	KRA58_HUMAN	keratin associated protein 5-8	55	9 X 4 AA repeats of C-C-X-P.					extracellular region|keratin filament	structural constituent of epidermis				0																		---	---	---	---
FOLR2	2350	broad.mit.edu	37	11	71932561	71932561	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:71932561T>G	uc009ytd.2	+	5	692	c.523T>G	c.(523-525)TAC>GAC	p.Y175D	FOLR2_uc009yte.2_Missense_Mutation_p.Y175D|FOLR2_uc001ose.3_Missense_Mutation_p.Y175D|FOLR2_uc009ytf.2_Missense_Mutation_p.Y175D	NM_001113534	NP_001107006	P14207	FOLR2_HUMAN	folate receptor 2 precursor	175					folic acid transport	anchored to membrane|extracellular region|membrane fraction|plasma membrane	folic acid binding|receptor activity			breast(2)|ovary(1)	3					Folic Acid(DB00158)													---	---	---	---
ARAP1	116985	broad.mit.edu	37	11	72424265	72424265	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:72424265G>A	uc001osu.2	-	5	892	c.703C>T	c.(703-705)CCA>TCA	p.P235S	ARAP1_uc001osv.2_Missense_Mutation_p.P235S|ARAP1_uc001osr.2_5'UTR|ARAP1_uc001oss.2_5'UTR|ARAP1_uc009yth.2_5'UTR|ARAP1_uc010rre.1_5'UTR	NM_001040118	NP_001035207	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	235					actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			skin(1)	1																		---	---	---	---
C2CD3	26005	broad.mit.edu	37	11	73820094	73820094	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:73820094T>C	uc001ouu.2	-	12	2174	c.1947A>G	c.(1945-1947)AAA>AAG	p.K649K		NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	649						centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)																	---	---	---	---
C2CD3	26005	broad.mit.edu	37	11	73820180	73820180	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:73820180G>A	uc001ouu.2	-	12	2088	c.1861C>T	c.(1861-1863)CGA>TGA	p.R621*		NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	621						centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)																	---	---	---	---
MAP6	4135	broad.mit.edu	37	11	75317002	75317002	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:75317002C>A	uc001owu.2	-	3	1232	c.1167G>T	c.(1165-1167)GCG>GCT	p.A389A	MAP6_uc001owv.2_Silent_p.A389A	NM_033063	NP_149052	Q96JE9	MAP6_HUMAN	microtubule-associated protein 6 isoform 1	389	Calmodulin-binding (By similarity).					Golgi apparatus|microtubule|perinuclear region of cytoplasm	calmodulin binding				0	Ovarian(111;0.11)																	---	---	---	---
INTS4	92105	broad.mit.edu	37	11	77639378	77639378	+	Intron	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:77639378A>G	uc001oys.2	-						INTS4_uc001oyt.2_Intron|INTS4_uc001oyu.1_Intron	NM_033547	NP_291025			integrator complex subunit 4						snRNA processing	integrator complex	protein binding			ovary(2)	2	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)															---	---	---	---
INTS4	92105	broad.mit.edu	37	11	77667073	77667073	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:77667073C>T	uc001oys.2	-	8	861	c.833G>A	c.(832-834)CGC>CAC	p.R278H	INTS4_uc001oyt.2_RNA|INTS4_uc001oyu.1_Missense_Mutation_p.R278H	NM_033547	NP_291025	Q96HW7	INT4_HUMAN	integrator complex subunit 4	278	HEAT 5.				snRNA processing	integrator complex	protein binding			ovary(2)	2	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)															---	---	---	---
ODZ4	26011	broad.mit.edu	37	11	78369281	78369281	+	Missense_Mutation	SNP	C	T	T	rs148029717	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:78369281C>T	uc001ozl.3	-	34	8595	c.8132G>A	c.(8131-8133)CGG>CAG	p.R2711Q	ODZ4_uc001ozk.3_Missense_Mutation_p.R936Q|ODZ4_uc009yvb.1_Intron	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	2711	Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4																		---	---	---	---
CCDC90B	60492	broad.mit.edu	37	11	82972951	82972951	+	3'UTR	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:82972951T>C	uc001pae.2	-	9					CCDC90B_uc001pac.2_3'UTR|CCDC90B_uc001pad.2_3'UTR|CCDC90B_uc001paf.2_3'UTR	NM_021825	NP_068597			coiled-coil domain containing 90B precursor							integral to membrane|mitochondrion|mitochondrion					0		Acute lymphoblastic leukemia(157;0.103)																---	---	---	---
GRM5	2915	broad.mit.edu	37	11	88241901	88241901	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:88241901C>T	uc001pcq.2	-	9	3698	c.3498G>A	c.(3496-3498)CCG>CCA	p.P1166P	GRM5_uc009yvm.2_Silent_p.P1134P	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	1166	Cytoplasmic (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)													---	---	---	---
GRM5	2915	broad.mit.edu	37	11	88300530	88300530	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:88300530A>T	uc001pcq.2	-	7	2521	c.2321T>A	c.(2320-2322)ATC>AAC	p.I774N	GRM5_uc009yvm.2_Missense_Mutation_p.I774N	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	774	Helical; Name=6; (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)													---	---	---	---
FAT3	120114	broad.mit.edu	37	11	92534857	92534857	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:92534857T>C	uc001pdj.3	+	9	8695	c.8678T>C	c.(8677-8679)GTG>GCG	p.V2893A		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2893	Cadherin 26.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)													TCGA Ovarian(4;0.039)			---	---	---	---
SLC36A4	120103	broad.mit.edu	37	11	92915960	92915960	+	Intron	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:92915960A>G	uc001pdn.2	-						SLC36A4_uc001pdm.2_Intron	NM_152313	NP_689526			solute carrier family 36 (proton/amino acid						L-alanine transport|proline transport|tryptophan transport	integral to membrane	symporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)																---	---	---	---
MED17	9440	broad.mit.edu	37	11	93529642	93529642	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:93529642A>G	uc001pem.3	+	7	1354	c.1079A>G	c.(1078-1080)GAG>GGG	p.E360G		NM_004268	NP_004259	Q9NVC6	MED17_HUMAN	mediator complex subunit 17	360					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)																---	---	---	---
MED17	9440	broad.mit.edu	37	11	93545010	93545010	+	Intron	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:93545010T>C	uc001pem.3	+							NM_004268	NP_004259			mediator complex subunit 17						androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)																---	---	---	---
MRE11A	4361	broad.mit.edu	37	11	94224123	94224123	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:94224123T>C	uc001peu.2	-	3	218	c.29A>G	c.(28-30)GAA>GGA	p.E10G	MRE11A_uc001pev.2_Missense_Mutation_p.E10G|MRE11A_uc009ywj.2_Missense_Mutation_p.E13G	NM_005591	NP_005582	P49959	MRE11_HUMAN	meiotic recombination 11 homolog A isoform 1	10					DNA duplex unwinding|double-strand break repair via homologous recombination|double-strand break repair via nonhomologous end joining|negative regulation of DNA endoreduplication|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|sister chromatid cohesion|telomere maintenance via telomerase	Mre11 complex|nucleoplasm	3'-5' exonuclease activity|double-stranded DNA binding|manganese ion binding|protein C-terminus binding|single-stranded DNA specific endodeoxyribonuclease activity			breast(4)|lung(1)	5		Acute lymphoblastic leukemia(157;2.37e-05)|all_hematologic(158;0.00824)											Homologous_recombination	Ataxia-Telangiectasia-Like_Disorder				---	---	---	---
SESN3	143686	broad.mit.edu	37	11	94910901	94910901	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:94910901T>C	uc001pfk.1	-	8	1451	c.1229A>G	c.(1228-1230)CAC>CGC	p.H410R	SESN3_uc010rug.1_Missense_Mutation_p.H271R	NM_144665	NP_653266	P58005	SESN3_HUMAN	sestrin 3	410					cell cycle arrest	nucleus					0		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)		BRCA - Breast invasive adenocarcinoma(274;0.234)														---	---	---	---
MMP8	4317	broad.mit.edu	37	11	102593239	102593239	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:102593239G>A	uc001phe.2	-	2	367	c.268C>T	c.(268-270)CGC>TGC	p.R90C	MMP8_uc010rut.1_Missense_Mutation_p.R25C|MMP8_uc010ruu.1_Missense_Mutation_p.R67C	NM_002424	NP_002415	P22894	MMP8_HUMAN	matrix metalloproteinase 8 preproprotein	90	Cysteine switch (By similarity).				collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase activity|zinc ion binding			ovary(3)|breast(1)	4	all_cancers(8;0.00092)|all_epithelial(12;0.00389)|Lung NSC(15;0.227)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0555)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.189)	BRCA - Breast invasive adenocarcinoma(274;0.0141)														---	---	---	---
GRIA4	2893	broad.mit.edu	37	11	105836774	105836774	+	Intron	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:105836774G>T	uc001pix.2	+						GRIA4_uc001piw.2_Nonsense_Mutation_p.G799*|GRIA4_uc010rvm.1_RNA|GRIA4_uc009yxl.1_RNA	NM_000829	NP_000820			glutamate receptor, ionotrophic, AMPA 4 isoform						glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)													---	---	---	---
KIAA1826	84437	broad.mit.edu	37	11	105881471	105881471	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:105881471T>C	uc001piy.2	-	2	347	c.174A>G	c.(172-174)GTA>GTG	p.V58V	KIAA1826_uc001piz.2_Silent_p.V58V	NM_032424	NP_115800	Q8NCY6	K1826_HUMAN	hypothetical protein LOC84437	58						nucleus				breast(1)	1		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.56e-05)|Epithelial(105;0.00432)|all cancers(92;0.0309)														---	---	---	---
SLC35F2	54733	broad.mit.edu	37	11	107675440	107675440	+	Intron	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:107675440A>G	uc001pjq.2	-						SLC35F2_uc010rvu.1_Intron|SLC35F2_uc001pjs.2_3'UTR	NM_017515	NP_059985			solute carrier family 35, member F2						transport	integral to membrane				central_nervous_system(1)	1		all_cancers(61;9.46e-06)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;0.000111)|all_hematologic(158;0.000315)|all_epithelial(67;0.00197)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)|Epithelial(105;0.000105)|all cancers(92;0.00217)														---	---	---	---
CUL5	8065	broad.mit.edu	37	11	107969130	107969130	+	Intron	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:107969130T>C	uc001pjv.2	+						CUL5_uc001pju.2_Intron	NM_003478	NP_003469			Vasopressin-activated calcium-mobilizing						cell cycle arrest|cell proliferation|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process|viral reproduction	cullin-RING ubiquitin ligase complex|cytosol	calcium channel activity|receptor activity|ubiquitin protein ligase binding			ovary(1)	1		all_cancers(61;7.09e-10)|all_epithelial(67;2.97e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|Melanoma(852;4.48e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;3.58e-05)|Epithelial(105;4.68e-05)|all cancers(92;0.00122)|OV - Ovarian serous cystadenocarcinoma(223;0.217)														---	---	---	---
DDX10	1662	broad.mit.edu	37	11	108593810	108593810	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:108593810C>T	uc001pkm.2	+	13	1651	c.1586C>T	c.(1585-1587)GCC>GTC	p.A529V	DDX10_uc001pkl.1_Missense_Mutation_p.A529V	NM_004398	NP_004389	Q13206	DDX10_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	529							ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity			breast(2)|lung(1)|prostate(1)	4		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)				T	NUP98	AML*								---	---	---	---
C11orf52	91894	broad.mit.edu	37	11	111796699	111796699	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:111796699G>T	uc001pmh.2	+	5	631	c.148G>T	c.(148-150)GGA>TGA	p.G50*	C11orf52_uc001pmi.2_Nonsense_Mutation_p.G50*	NM_080659	NP_542390	Q96A22	CK052_HUMAN	hypothetical protein LOC91894	50										ovary(1)	1		all_cancers(61;8.8e-15)|all_epithelial(67;6.27e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;3.63e-07)|BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|all cancers(92;6.7e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0512)														---	---	---	---
FAM55D	54827	broad.mit.edu	37	11	114453454	114453454	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:114453454C>A	uc001ppc.2	-	3	567	c.386G>T	c.(385-387)CGC>CTC	p.R129L	FAM55D_uc001ppd.2_Intron	NM_001077639	NP_001071107	Q6UWF7	FA55D_HUMAN	hypothetical protein LOC54827 isoform 1	129						extracellular region				ovary(2)|skin(2)	4		all_cancers(61;8.53e-16)|all_epithelial(67;1.71e-08)|all_hematologic(158;3.05e-05)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0194)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;2.82e-06)|Epithelial(105;0.000129)|all cancers(92;0.000938)														---	---	---	---
APOA5	116519	broad.mit.edu	37	11	116660973	116660973	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:116660973G>A	uc001ppr.2	-	3	980	c.972C>T	c.(970-972)TTC>TTT	p.F324F	ZNF259_uc001ppp.2_5'Flank|ZNF259_uc009yzd.2_5'Flank|ZNF259_uc001ppq.2_5'Flank|APOA5_uc009yze.2_Silent_p.F324F|APOA5_uc009yzf.2_Silent_p.F324F|APOA5_uc009yzg.2_Silent_p.F350F	NM_052968	NP_443200	Q6Q788	APOA5_HUMAN	apolipoprotein AV precursor	324					acylglycerol homeostasis|cholesterol homeostasis|lipid transport|lipoprotein metabolic process|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor-mediated endocytosis|positive regulation of triglyceride catabolic process|positive regulation of very-low-density lipoprotein particle remodeling|tissue regeneration|triglyceride catabolic process|triglyceride homeostasis	chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	enzyme binding|heparin binding|lipoprotein lipase activator activity|low-density lipoprotein particle receptor binding|phosphatidylcholine binding				0	all_hematologic(175;0.0487)	all_cancers(61;3.31e-09)|all_epithelial(67;8.03e-06)|Breast(348;0.0126)|Melanoma(852;0.0153)|Acute lymphoblastic leukemia(157;0.0257)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0433)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;4.93e-06)|all cancers(92;0.000123)|OV - Ovarian serous cystadenocarcinoma(223;0.149)														---	---	---	---
SIK3	23387	broad.mit.edu	37	11	116767059	116767059	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:116767059C>T	uc001ppy.2	-	6	637	c.601G>A	c.(601-603)GGT>AGT	p.G201S	SIK3_uc001ppz.2_Missense_Mutation_p.G100S|SIK3_uc001pqa.2_Missense_Mutation_p.G201S	NM_025164	NP_079440	Q9Y2K2	SIK3_HUMAN	serine/threonine-protein kinase QSK	201	Protein kinase.					cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|breast(3)|stomach(2)|lung(1)|skin(1)|kidney(1)	12																		---	---	---	---
DSCAML1	57453	broad.mit.edu	37	11	117303920	117303920	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:117303920G>A	uc001prh.1	-	29	5142	c.5140C>T	c.(5140-5142)CGG>TGG	p.R1714W		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1654	Cytoplasmic (Potential).				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)														---	---	---	---
UBE4A	9354	broad.mit.edu	37	11	118255401	118255401	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118255401C>A	uc001psw.2	+	14	2378	c.2249C>A	c.(2248-2250)CCT>CAT	p.P750H	UBE4A_uc001psv.2_Missense_Mutation_p.P757H	NM_004788	NP_004779	Q14139	UBE4A_HUMAN	ubiquitination factor E4A	750					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	5	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)														---	---	---	---
MLL	4297	broad.mit.edu	37	11	118363823	118363823	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118363823C>T	uc001pta.2	+	16	5070	c.5047C>T	c.(5047-5049)CGC>TGC	p.R1683C	MLL_uc001ptb.2_Missense_Mutation_p.R1686C	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1683					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)				T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								---	---	---	---
ARCN1	372	broad.mit.edu	37	11	118463520	118463520	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118463520G>A	uc001ptq.2	+	7	1242	c.1081G>A	c.(1081-1083)GTG>ATG	p.V361M	ARCN1_uc009zah.2_Intron|ARCN1_uc010ryg.1_Missense_Mutation_p.V273M|ARCN1_uc009zag.2_Missense_Mutation_p.V402M	NM_001655	NP_001646	P48444	COPD_HUMAN	archain isoform 1	361	MHD.				COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	clathrin adaptor complex|COPI vesicle coat|cytosol					0	all_hematologic(175;0.0349)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)														---	---	---	---
BCL9L	283149	broad.mit.edu	37	11	118770759	118770759	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118770759C>T	uc001pug.2	-	7	4238	c.3273G>A	c.(3271-3273)ATG>ATA	p.M1091I	BCL9L_uc009zal.2_Missense_Mutation_p.M1086I	NM_182557	NP_872363	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	1091	Pro-rich.				negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			ovary(1)|pancreas(1)	2	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)														---	---	---	---
ABCG4	64137	broad.mit.edu	37	11	119025010	119025010	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:119025010C>T	uc001pvs.2	+	4	733	c.397C>T	c.(397-399)CCA>TCA	p.P133S	ABCG4_uc009zar.2_Missense_Mutation_p.P133S	NM_022169	NP_071452	Q9H172	ABCG4_HUMAN	ATP-binding cassette, subfamily G, member 4	133	Cytoplasmic (Potential).|ABC transporter.				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)														---	---	---	---
GRIK4	2900	broad.mit.edu	37	11	120837900	120837900	+	Intron	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:120837900G>A	uc001pxn.2	+						GRIK4_uc009zaw.1_Intron|GRIK4_uc009zax.1_Intron	NM_014619	NP_055434			glutamate receptor KA1 precursor						glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|central_nervous_system(1)	3		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)													---	---	---	---
OR10G4	390264	broad.mit.edu	37	11	123886785	123886785	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:123886785T>C	uc010sac.1	+	1	504	c.504T>C	c.(502-504)TGT>TGC	p.C168C		NM_001004462	NP_001004462	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G,	168	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)														---	---	---	---
OR10G7	390265	broad.mit.edu	37	11	123909205	123909205	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:123909205A>G	uc001pzq.1	-	1	504	c.504T>C	c.(502-504)TGT>TGC	p.C168C		NM_001004463	NP_001004463	Q8NGN6	O10G7_HUMAN	olfactory receptor, family 10, subfamily G,	168	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)														---	---	---	---
CHEK1	1111	broad.mit.edu	37	11	125497499	125497499	+	Intron	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:125497499T>C	uc009zbo.2	+						CHEK1_uc010sbh.1_Intron|CHEK1_uc010sbi.1_Intron|CHEK1_uc001qcf.3_Intron|CHEK1_uc009zbp.2_Intron|CHEK1_uc001qcg.3_Intron|CHEK1_uc009zbq.2_Intron|CHEK1_uc001qci.1_Intron	NM_001114122	NP_001107594			checkpoint kinase 1						cellular response to mechanical stimulus|DNA repair|DNA replication|gamete generation|negative regulation of cell proliferation|reciprocal meiotic recombination|regulation of cyclin-dependent protein kinase activity|replicative senescence	condensed nuclear chromosome|microtubule organizing center|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(3)|lung(2)|skin(1)	6	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0748)									Other_conserved_DNA_damage_response_genes					---	---	---	---
PUS3	83480	broad.mit.edu	37	11	125765567	125765567	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:125765567G>A	uc001qcy.2	-	3	594	c.496C>T	c.(496-498)CGG>TGG	p.R166W	HYLS1_uc009zbv.2_Intron|HYLS1_uc001qcx.3_Intron	NM_031307	NP_112597	Q9BZE2	PUS3_HUMAN	pseudouridylate synthase 3	166						nucleus	RNA binding			ovary(1)	1	all_hematologic(175;0.177)	Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.131)|all_lung(97;0.139)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.043)														---	---	---	---
RPUSD4	84881	broad.mit.edu	37	11	126081486	126081486	+	Silent	SNP	G	A	A	rs141244684	byFrequency	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:126081486G>A	uc001qde.2	-	1	102	c.48C>T	c.(46-48)AAC>AAT	p.N16N	FAM118B_uc001qdf.2_5'Flank|FAM118B_uc009zca.2_5'Flank|FAM118B_uc001qdg.2_5'Flank|RPUSD4_uc009zbz.2_Silent_p.N16N|RPUSD4_uc009zby.2_RNA	NM_032795	NP_116184	Q96CM3	RUSD4_HUMAN	RNA pseudouridylate synthase domain containing 4	16					pseudouridine synthesis		protein binding|pseudouridine synthase activity|RNA binding			breast(1)	1	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0919)|all_lung(97;0.0994)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0761)														---	---	---	---
SRPR	6734	broad.mit.edu	37	11	126136516	126136516	+	Missense_Mutation	SNP	G	A	A	rs148507841		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:126136516G>A	uc001qdh.2	-	6	746	c.695C>T	c.(694-696)ACG>ATG	p.T232M	SRPR_uc010sbm.1_Missense_Mutation_p.T204M|FOXRED1_uc001qdi.2_5'Flank|FOXRED1_uc010sbn.1_5'Flank|FOXRED1_uc010sbo.1_5'Flank|FOXRED1_uc010sbp.1_5'Flank|FOXRED1_uc010sbq.1_5'Flank|FOXRED1_uc001qdj.2_5'Flank|FOXRED1_uc010sbr.1_5'Flank	NM_003139	NP_003130	P08240	SRPR_HUMAN	signal recognition particle receptor	232					SRP-dependent cotranslational protein targeting to membrane	integral to membrane|signal recognition particle receptor complex	GTP binding|GTPase activity|receptor activity|signal recognition particle binding				0	all_hematologic(175;0.145)			BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0736)														---	---	---	---
ARHGAP32	9743	broad.mit.edu	37	11	128844793	128844793	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:128844793T>C	uc009zcp.2	-	20	2257	c.2257A>G	c.(2257-2259)AAT>GAT	p.N753D	ARHGAP32_uc009zcq.1_Missense_Mutation_p.N713D|ARHGAP32_uc009zco.2_Translation_Start_Site|ARHGAP32_uc001qez.2_Missense_Mutation_p.N404D	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	753					cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5																		---	---	---	---
PRDM10	56980	broad.mit.edu	37	11	129775589	129775589	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:129775589T>C	uc001qfm.2	-	21	3455	c.3223A>G	c.(3223-3225)ACA>GCA	p.T1075A	PRDM10_uc001qfj.2_Missense_Mutation_p.T976A|PRDM10_uc001qfk.2_Missense_Mutation_p.T938A|PRDM10_uc001qfl.2_Missense_Mutation_p.T989A|PRDM10_uc010sbx.1_Missense_Mutation_p.T985A|PRDM10_uc001qfn.2_Missense_Mutation_p.T1071A	NM_020228	NP_064613	Q9NQV6	PRD10_HUMAN	PR domain containing 10 isoform 1	1062					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)														---	---	---	---
SNX19	399979	broad.mit.edu	37	11	130750587	130750587	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:130750587G>T	uc001qgk.3	-	9	3236	c.2688C>A	c.(2686-2688)CCC>CCA	p.P896P	SNX19_uc009zcw.2_Silent_p.P133P|SNX19_uc010sce.1_Silent_p.P276P|SNX19_uc010scf.1_Silent_p.P339P|SNX19_uc010scg.1_Silent_p.P133P	NM_014758	NP_055573	Q92543	SNX19_HUMAN	sorting nexin 19	896					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			ovary(2)|lung(2)	4	all_hematologic(175;0.0597)	Lung NSC(97;0.000272)|all_lung(97;0.000608)|Breast(109;0.000962)|all_neural(223;0.0298)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;0.0195)|Lung(977;0.233)														---	---	---	---
SLC6A13	6540	broad.mit.edu	37	12	333237	333237	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:333237C>T	uc001qic.1	-	11	1285	c.1232G>A	c.(1231-1233)CGC>CAC	p.R411H	SLC6A13_uc009zdj.1_Missense_Mutation_p.R401H|SLC6A13_uc010sdl.1_Missense_Mutation_p.R319H	NM_016615	NP_057699	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter	411					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)															---	---	---	---
KDM5A	5927	broad.mit.edu	37	12	442691	442691	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:442691T>C	uc001qif.1	-	12	1978	c.1615A>G	c.(1615-1617)ATC>GTC	p.I539V	KDM5A_uc001qie.1_Missense_Mutation_p.I539V|KDM5A_uc010sdn.1_Missense_Mutation_p.I498V|KDM5A_uc010sdo.1_Missense_Mutation_p.I158V	NM_001042603	NP_001036068	P29375	KDM5A_HUMAN	retinoblastoma binding protein 2 isoform 1	539	JmjC.				chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|ovary(1)	3								T 	NUP98	AML								---	---	---	---
NINJ2	4815	broad.mit.edu	37	12	675348	675348	+	Intron	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:675348T>C	uc001qil.2	-						NINJ2_uc010sdr.1_Intron|NINJ2_uc010sds.1_Intron	NM_016533	NP_057617			ninjurin 2						nervous system development|neuron cell-cell adhesion|tissue regeneration	integral to plasma membrane				ovary(2)	2	all_cancers(10;0.0101)|all_epithelial(11;0.0174)|Ovarian(42;0.0512)|all_lung(10;0.103)|Lung NSC(10;0.185)		OV - Ovarian serous cystadenocarcinoma(31;3.26e-05)|BRCA - Breast invasive adenocarcinoma(9;0.0508)															---	---	---	---
RAD52	5893	broad.mit.edu	37	12	1036391	1036391	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:1036391A>G	uc001qis.1	-	6	501	c.387T>C	c.(385-387)AGT>AGC	p.S129S	RAD52_uc001qit.1_RNA|RAD52_uc010sdt.1_Silent_p.S52S|RAD52_uc001qiu.1_Silent_p.S129S|RAD52_uc001qiv.1_RNA|RAD52_uc001qiw.1_Intron|RAD52_uc010sdu.1_Silent_p.S129S|RAD52_uc001qix.1_Silent_p.S129S	NM_134424	NP_602296	P43351	RAD52_HUMAN	RAD52 homolog	129					DNA recombinase assembly|mitotic recombination|reciprocal meiotic recombination	nucleoplasm	DNA binding|protein binding			central_nervous_system(1)	1	all_cancers(10;0.0119)|all_epithelial(11;0.0171)|all_lung(10;0.0521)|Ovarian(42;0.0816)|Lung NSC(10;0.0987)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.0323)										Homologous_recombination					---	---	---	---
CACNA1C	775	broad.mit.edu	37	12	2692102	2692102	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:2692102G>A	uc009zdu.1	+	15	2531	c.2218G>A	c.(2218-2220)GGA>AGA	p.G740R	CACNA1C_uc009zdv.1_Missense_Mutation_p.G737R|CACNA1C_uc001qkb.2_Missense_Mutation_p.G740R|CACNA1C_uc001qkc.2_Missense_Mutation_p.G740R|CACNA1C_uc001qke.2_Missense_Mutation_p.G740R|CACNA1C_uc001qkf.2_Missense_Mutation_p.G740R|CACNA1C_uc001qjz.2_Missense_Mutation_p.G740R|CACNA1C_uc001qkd.2_Missense_Mutation_p.G740R|CACNA1C_uc001qkg.2_Missense_Mutation_p.G740R|CACNA1C_uc009zdw.1_Missense_Mutation_p.G740R|CACNA1C_uc001qkh.2_Missense_Mutation_p.G740R|CACNA1C_uc001qkl.2_Missense_Mutation_p.G740R|CACNA1C_uc001qkn.2_Missense_Mutation_p.G740R|CACNA1C_uc001qko.2_Missense_Mutation_p.G740R|CACNA1C_uc001qkp.2_Missense_Mutation_p.G740R|CACNA1C_uc001qkr.2_Missense_Mutation_p.G740R|CACNA1C_uc001qku.2_Missense_Mutation_p.G740R|CACNA1C_uc001qkq.2_Missense_Mutation_p.G740R|CACNA1C_uc001qks.2_Missense_Mutation_p.G740R|CACNA1C_uc001qkt.2_Missense_Mutation_p.G740R|CACNA1C_uc001qka.1_Missense_Mutation_p.G275R|CACNA1C_uc001qki.1_Missense_Mutation_p.G476R|CACNA1C_uc001qkj.1_Missense_Mutation_p.G476R|CACNA1C_uc001qkk.1_Missense_Mutation_p.G476R|CACNA1C_uc001qkm.1_Missense_Mutation_p.G476R|CACNA1C_uc001qkw.2_Missense_Mutation_p.G29R	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	740	Helical; Name=S6 of repeat II; (Potential).|II.				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)													---	---	---	---
CACNA1C	775	broad.mit.edu	37	12	2764356	2764356	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:2764356G>A	uc009zdu.1	+	36	4641	c.4328G>A	c.(4327-4329)CGG>CAG	p.R1443Q	CACNA1C_uc009zdv.1_Missense_Mutation_p.R1392Q|CACNA1C_uc001qkb.2_Missense_Mutation_p.R1395Q|CACNA1C_uc001qkc.2_Missense_Mutation_p.R1395Q|CACNA1C_uc001qke.2_Missense_Mutation_p.R1384Q|CACNA1C_uc001qkf.2_Missense_Mutation_p.R1384Q|CACNA1C_uc001qjz.2_Missense_Mutation_p.R1395Q|CACNA1C_uc001qkd.2_Missense_Mutation_p.R1395Q|CACNA1C_uc001qkg.2_Missense_Mutation_p.R1382Q|CACNA1C_uc009zdw.1_Missense_Mutation_p.R1417Q|CACNA1C_uc001qkh.2_Missense_Mutation_p.R1384Q|CACNA1C_uc001qkl.2_Missense_Mutation_p.R1443Q|CACNA1C_uc001qkn.2_Missense_Mutation_p.R1395Q|CACNA1C_uc001qko.2_Missense_Mutation_p.R1415Q|CACNA1C_uc001qkp.2_Missense_Mutation_p.R1395Q|CACNA1C_uc001qkr.2_Missense_Mutation_p.R1412Q|CACNA1C_uc001qku.2_Missense_Mutation_p.R1395Q|CACNA1C_uc001qkq.2_Missense_Mutation_p.R1423Q|CACNA1C_uc001qks.2_Missense_Mutation_p.R1395Q|CACNA1C_uc001qkt.2_Missense_Mutation_p.R1395Q|CACNA1C_uc001qki.1_Missense_Mutation_p.R1131Q|CACNA1C_uc001qkj.1_Missense_Mutation_p.R1131Q|CACNA1C_uc001qkk.1_Missense_Mutation_p.R1131Q|CACNA1C_uc001qkm.1_Missense_Mutation_p.R1120Q|CACNA1C_uc010sea.1_Missense_Mutation_p.R86Q	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	1443	Extracellular (Potential).|IV.				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)													---	---	---	---
FKBP4	2288	broad.mit.edu	37	12	2907948	2907948	+	Missense_Mutation	SNP	G	A	A	rs1062478		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:2907948G>A	uc001qkz.2	+	4	668	c.470G>A	c.(469-471)CGC>CAC	p.R157H		NM_002014	NP_002005	Q02790	FKBP4_HUMAN	FK506 binding protein 52	157					negative regulation of microtubule polymerization or depolymerization|negative regulation of neuron projection development|protein folding	axonal growth cone|cytosol|membrane|microtubule|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity|protein binding, bridging				0			OV - Ovarian serous cystadenocarcinoma(31;0.00105)		Dimethyl sulfoxide(DB01093)													---	---	---	---
ITFG2	55846	broad.mit.edu	37	12	2929961	2929961	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:2929961G>A	uc001qlb.1	+	6	682	c.618G>A	c.(616-618)GCG>GCA	p.A206A	ITFG2_uc010seb.1_Silent_p.A29A|ITFG2_uc010sec.1_RNA	NM_018463	NP_060933	Q969R8	ITFG2_HUMAN	integrin alpha FG-GAP repeat containing 2	206											0			OV - Ovarian serous cystadenocarcinoma(31;0.000818)															---	---	---	---
KCNA5	3741	broad.mit.edu	37	12	5153819	5153819	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:5153819G>A	uc001qni.2	+	1	735	c.506G>A	c.(505-507)CGG>CAG	p.R169Q		NM_002234	NP_002225	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related	169						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(2)|breast(2)	4																		---	---	---	---
CD9	928	broad.mit.edu	37	12	6309658	6309658	+	5'UTR	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:6309658C>T	uc001qnp.1	+	2					CD9_uc010seu.1_5'UTR|CD9_uc010sev.1_5'UTR|CD9_uc001qnq.1_5'UTR	NM_001769	NP_001760			CD9 antigen						cell adhesion|cellular component movement|fusion of sperm to egg plasma membrane|paranodal junction assembly|platelet activation|platelet degranulation	integral to plasma membrane|platelet alpha granule membrane				ovary(1)	1																		---	---	---	---
CHD4	1108	broad.mit.edu	37	12	6692419	6692419	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:6692419T>G	uc001qpo.2	-	26	4169	c.4005A>C	c.(4003-4005)AAA>AAC	p.K1335N	CHD4_uc001qpn.2_Missense_Mutation_p.K1328N|CHD4_uc001qpp.2_Missense_Mutation_p.K1332N|uc001qpq.1_3'UTR|SCARNA11_uc001qpr.1_5'Flank	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1335					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2																		---	---	---	---
CHD4	1108	broad.mit.edu	37	12	6703755	6703755	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:6703755G>T	uc001qpo.2	-	15	2347	c.2183C>A	c.(2182-2184)CCC>CAC	p.P728H	CHD4_uc001qpn.2_Missense_Mutation_p.P721H|CHD4_uc001qpp.2_Missense_Mutation_p.P725H	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	728					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2																		---	---	---	---
CHD4	1108	broad.mit.edu	37	12	6707515	6707515	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:6707515G>T	uc001qpo.2	-	11	1723	c.1559C>A	c.(1558-1560)CCT>CAT	p.P520H	CHD4_uc001qpn.2_Missense_Mutation_p.P513H|CHD4_uc001qpp.2_Missense_Mutation_p.P517H	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	520	Chromo 1.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2																		---	---	---	---
ACRBP	84519	broad.mit.edu	37	12	6753468	6753468	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:6753468G>T	uc001qpu.1	-	5	827	c.779C>A	c.(778-780)TCT>TAT	p.S260Y	ACRBP_uc010sfg.1_Missense_Mutation_p.S227Y	NM_032489	NP_115878	Q8NEB7	ACRBP_HUMAN	proacrosin binding protein sp32 precursor	260						acrosomal vesicle|extracellular region				central_nervous_system(1)	1																		---	---	---	---
ATN1	1822	broad.mit.edu	37	12	7044832	7044832	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:7044832T>C	uc001qrw.1	+	5	639	c.402T>C	c.(400-402)AGT>AGC	p.S134S	ATN1_uc001qrx.1_Silent_p.S134S|ATN1_uc001qry.1_Silent_p.S133S	NM_001007026	NP_001007027	P54259	ATN1_HUMAN	atrophin-1	134					cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6																		---	---	---	---
CLEC4A	50856	broad.mit.edu	37	12	8290795	8290795	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:8290795G>A	uc001qtz.1	+	6	873	c.626G>A	c.(625-627)CGT>CAT	p.R209H	CLEC4A_uc009zga.1_Missense_Mutation_p.R170H|CLEC4A_uc001qub.1_Missense_Mutation_p.R176H|CLEC4A_uc001quc.1_Missense_Mutation_p.R137H|CLEC4A_uc009zgb.1_3'UTR	NM_016184	NP_057268	Q9UMR7	CLC4A_HUMAN	C-type lectin domain family 4, member A isoform	209	Extracellular (Potential).|C-type lectin.				cell adhesion|cell surface receptor linked signaling pathway|innate immune response	integral to plasma membrane	sugar binding|transmembrane receptor activity				0				Kidney(36;0.0915)														---	---	---	---
RIMKLB	57494	broad.mit.edu	37	12	8926340	8926340	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:8926340A>G	uc001quu.2	+	6	1372	c.1121A>G	c.(1120-1122)AAC>AGC	p.N374S	RIMKLB_uc009zgf.1_Intron|RIMKLB_uc001qux.2_Missense_Mutation_p.N374S|RIMKLB_uc010sgl.1_Missense_Mutation_p.N374S|RIMKLB_uc001quw.2_Intron	NM_020734	NP_065785	Q9ULI2	RIMKB_HUMAN	ribosomal modification protein rimK-like family	374					protein modification process	cytoplasm	acid-amino acid ligase activity|ATP binding|metal ion binding				0																		---	---	---	---
M6PR	4074	broad.mit.edu	37	12	9095057	9095057	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:9095057C>T	uc001qvf.2	-	6	836	c.666G>A	c.(664-666)CAG>CAA	p.Q222Q		NM_002355	NP_002346	P20645	MPRD_HUMAN	cation-dependent mannose-6-phosphate receptor	222	Cytoplasmic (Potential).				endosome to lysosome transport|receptor-mediated endocytosis	cell surface|endosome|integral to plasma membrane|lysosomal membrane	mannose binding|mannose transmembrane transporter activity|transmembrane receptor activity				0		Hepatocellular(102;0.137)		BRCA - Breast invasive adenocarcinoma(232;0.0146)														---	---	---	---
BCL2L14	79370	broad.mit.edu	37	12	12247797	12247797	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:12247797T>C	uc001rac.2	+	5	1079	c.878T>C	c.(877-879)GTC>GCC	p.V293A	ETV6_uc001raa.1_Intron|BCL2L14_uc001raf.1_Intron|BCL2L14_uc001rad.2_Missense_Mutation_p.V293A|BCL2L14_uc001rae.2_3'UTR	NM_138723	NP_620049	Q9BZR8	B2L14_HUMAN	BCL2-like 14 isoform 1	293					apoptosis|regulation of apoptosis	cytosol|endomembrane system|intracellular organelle|membrane	protein binding			skin(1)	1		Prostate(47;0.0872)		BRCA - Breast invasive adenocarcinoma(232;0.154)														---	---	---	---
LRP6	4040	broad.mit.edu	37	12	12339968	12339968	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:12339968G>A	uc001rah.3	-	4	875	c.733C>T	c.(733-735)CAC>TAC	p.H245Y	BCL2L14_uc001raf.1_Intron|LRP6_uc010shl.1_Missense_Mutation_p.H245Y	NM_002336	NP_002327	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein	245	Extracellular (Potential).|Beta-propeller 1.|LDL-receptor class B 5.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)																---	---	---	---
LMO3	55885	broad.mit.edu	37	12	16713448	16713448	+	Silent	SNP	G	A	A	rs149014326		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:16713448G>A	uc001rdk.1	-	3	671	c.231C>T	c.(229-231)TGC>TGT	p.C77C	LMO3_uc001rdj.1_Silent_p.C88C|LMO3_uc010shy.1_Silent_p.C95C|LMO3_uc001rdl.1_Silent_p.C77C|LMO3_uc009zii.1_RNA|LMO3_uc010shz.1_Silent_p.C99C|LMO3_uc001rdm.1_Silent_p.C77C|LMO3_uc001rdo.1_RNA|LMO3_uc001rdp.1_RNA|LMO3_uc001rdn.1_Silent_p.C77C|LMO3_uc009zij.1_RNA|LMO3_uc009zik.1_RNA	NM_018640	NP_061110	Q8TAP4	LMO3_HUMAN	LIM domain only 3	77	LIM zinc-binding 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent		zinc ion binding				0		Hepatocellular(102;0.244)																---	---	---	---
RECQL	5965	broad.mit.edu	37	12	21628712	21628712	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:21628712A>G	uc001rex.2	-	10	1344	c.996T>C	c.(994-996)GTT>GTC	p.V332V	RECQL_uc001rey.2_Silent_p.V332V	NM_032941	NP_116559	P46063	RECQ1_HUMAN	RecQ protein-like	332	Helicase C-terminal.				DNA recombination|DNA repair|DNA replication	nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|DNA strand annealing activity|protein binding			ovary(1)|lung(1)	2													Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					---	---	---	---
ABCC9	10060	broad.mit.edu	37	12	22086854	22086854	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:22086854C>A	uc001rfi.1	-	2	166	c.146G>T	c.(145-147)TGG>TTG	p.W49L	ABCC9_uc001rfh.2_Missense_Mutation_p.W49L|ABCC9_uc001rfj.1_Missense_Mutation_p.W49L|ABCC9_uc001rfk.2_Missense_Mutation_p.W49L|ABCC9_uc001rfl.1_Missense_Mutation_p.W49L	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	49	Helical; Name=1; (Potential).				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)													---	---	---	---
KRAS	3845	broad.mit.edu	37	12	25398281	25398281	+	Missense_Mutation	SNP	C	T	T	rs112445441		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:25398281C>T	uc001rgp.1	-	2	219	c.38G>A	c.(37-39)GGC>GAC	p.G13D	KRAS_uc001rgq.1_Missense_Mutation_p.G13D|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	13	GTP.		G -> R (in pylocytic astrocytoma; somatic mutation; increase activation of the Ras pathway).|G -> D (in a breast carcinoma cell line and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G13D(2647)|p.G13C(182)|p.G13S(58)|p.G13R(41)|p.G13V(27)|p.G13A(24)|p.G13G(11)|p.G13E(4)|p.G12_G13insG(4)|p.G13N(3)|p.G13I(1)|p.G13_V14>DI(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			G13D(NCIH647_LUNG)|G13D(MDAMB231_BREAST)|G13D(NCIH747_LARGE_INTESTINE)|G13D(T84_LARGE_INTESTINE)|G13D(LOVO_LARGE_INTESTINE)|G13D(DLD1_LARGE_INTESTINE)|G13D(DV90_LUNG)|G13D(HCT15_LARGE_INTESTINE)|G13D(HCT116_LARGE_INTESTINE)|G13D(TOLEDO_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G13D(NOMO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			---	---	---	---
ABCD2	225	broad.mit.edu	37	12	40013372	40013372	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:40013372T>C	uc001rmb.2	-	1	472	c.46A>G	c.(46-48)AGA>GGA	p.R16G		NM_005164	NP_005155	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D, member 2	16	Interaction with PEX19.				fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|central_nervous_system(1)|skin(1)	6																		---	---	---	---
PRICKLE1	144165	broad.mit.edu	37	12	42859016	42859016	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:42859016C>T	uc010skv.1	-	7	1107	c.820G>A	c.(820-822)GCC>ACC	p.A274T	PRICKLE1_uc001rnl.2_Missense_Mutation_p.A274T|PRICKLE1_uc010skw.1_Missense_Mutation_p.A274T|PRICKLE1_uc001rnm.2_Missense_Mutation_p.A274T	NM_001144881	NP_001138353	Q96MT3	PRIC1_HUMAN	prickle homolog 1	274	LIM zinc-binding 3.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			ovary(3)|skin(1)	4	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)														---	---	---	---
SLC38A4	55089	broad.mit.edu	37	12	47178327	47178327	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:47178327C>T	uc001rpi.2	-	7	890	c.491G>A	c.(490-492)GGA>GAA	p.G164E	SLC38A4_uc001rpj.2_Missense_Mutation_p.G164E|SLC38A4_uc009zkl.2_Missense_Mutation_p.G164E	NM_018018	NP_060488	Q969I6	S38A4_HUMAN	solute carrier family 38, member 4	164	Helical; (Potential).				cellular nitrogen compound metabolic process|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Lung SC(27;0.192)|Renal(347;0.236)																	---	---	---	---
ADCY6	112	broad.mit.edu	37	12	49167430	49167430	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49167430A>G	uc001rsh.3	-	15	3103	c.2443T>C	c.(2443-2445)TAC>CAC	p.Y815H	ADCY6_uc001rsj.3_Missense_Mutation_p.Y815H|ADCY6_uc001rsi.3_Missense_Mutation_p.Y762H|ADCY6_uc010slw.1_Missense_Mutation_p.Y46H	NM_015270	NP_056085	O43306	ADCY6_HUMAN	adenylate cyclase 6 isoform a	815	Extracellular (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding				0																		---	---	---	---
MLL2	8085	broad.mit.edu	37	12	49434800	49434800	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49434800C>T	uc001rta.3	-	31	6753	c.6753G>A	c.(6751-6753)TCG>TCA	p.S2251S		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2251	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41								N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			---	---	---	---
DIP2B	57609	broad.mit.edu	37	12	51100412	51100412	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:51100412T>C	uc001rwv.2	+	21	2654	c.2498T>C	c.(2497-2499)TTG>TCG	p.L833S	DIP2B_uc009zlt.2_Missense_Mutation_p.L263S	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	833						nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6																		---	---	---	---
SLC4A8	9498	broad.mit.edu	37	12	51865099	51865099	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:51865099C>T	uc001rys.1	+	14	1865	c.1687C>T	c.(1687-1689)CGA>TGA	p.R563*	SLC4A8_uc010sni.1_Nonsense_Mutation_p.R510*|SLC4A8_uc001rym.2_Nonsense_Mutation_p.R510*|SLC4A8_uc001ryn.2_Nonsense_Mutation_p.R510*|SLC4A8_uc001ryo.2_Nonsense_Mutation_p.R510*|SLC4A8_uc010snj.1_Nonsense_Mutation_p.R590*|SLC4A8_uc001ryq.3_Nonsense_Mutation_p.R563*|SLC4A8_uc001ryr.2_Nonsense_Mutation_p.R563*|SLC4A8_uc010snk.1_Nonsense_Mutation_p.R510*	NM_001039960	NP_001035049	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate	563	Extracellular (Potential).				bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			ovary(3)|pancreas(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.15)														---	---	---	---
KRT84	3890	broad.mit.edu	37	12	52779139	52779139	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:52779139G>A	uc001sah.1	-	1	279	c.231C>T	c.(229-231)GTC>GTT	p.V77V		NM_033045	NP_149034	Q9NSB2	KRT84_HUMAN	keratin, hair, basic, 4	77	Head.					keratin filament	structural constituent of epidermis			skin(1)	1	all_hematologic(5;0.12)			BRCA - Breast invasive adenocarcinoma(357;0.189)														---	---	---	---
KRT74	121391	broad.mit.edu	37	12	52960950	52960950	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:52960950C>A	uc001sap.1	-	9	1441	c.1393G>T	c.(1393-1395)GTC>TTC	p.V465F		NM_175053	NP_778223	Q7RTS7	K2C74_HUMAN	keratin 6 irs4	465	Tail.					keratin filament	structural molecule activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.191)														---	---	---	---
KRT18	3875	broad.mit.edu	37	12	53343180	53343180	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:53343180G>A	uc001sbe.2	+	2	292	c.223G>A	c.(223-225)GGA>AGA	p.G75R	KRT18_uc009zmn.1_Missense_Mutation_p.G75R|KRT18_uc001sbf.1_5'UTR|KRT18_uc001sbg.2_Missense_Mutation_p.G75R|KRT18_uc009zmo.2_Missense_Mutation_p.G75R|KRT8_uc009zml.1_Intron|KRT8_uc009zmm.1_Intron	NM_199187	NP_954657	P05783	K1C18_HUMAN	keratin 18	75	Head.|Necessary for interaction with PNN.				anatomical structure morphogenesis|cell cycle|Golgi to plasma membrane CFTR protein transport|interspecies interaction between organisms|negative regulation of apoptosis	centriolar satellite|keratin filament|perinuclear region of cytoplasm	protein binding|structural molecule activity			skin(1)	1																		---	---	---	---
AMHR2	269	broad.mit.edu	37	12	53818978	53818978	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:53818978C>T	uc001scx.1	+	4	532	c.454C>T	c.(454-456)CTG>TTG	p.L152L	AMHR2_uc009zmy.1_Silent_p.L152L	NM_020547	NP_065434	Q16671	AMHR2_HUMAN	anti-Mullerian hormone receptor, type II isoform	152	Helical; (Potential).				Mullerian duct regression		ATP binding|hormone binding|metal ion binding			ovary(1)|skin(1)	2					Adenosine triphosphate(DB00171)									Persistant_Mullerian_Duct_Syndrome_(type_I_and_II)				---	---	---	---
ITGA5	3678	broad.mit.edu	37	12	54801974	54801974	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:54801974T>C	uc001sga.2	-	7	805	c.737A>G	c.(736-738)TAC>TGC	p.Y246C	ITGA5_uc010sow.1_RNA|ITGA5_uc009znp.1_RNA	NM_002205	NP_002196	P08648	ITA5_HUMAN	integrin alpha 5 precursor	246	Extracellular (Potential).				angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			ovary(2)	2																		---	---	---	---
LACRT	90070	broad.mit.edu	37	12	55025549	55025549	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:55025549C>T	uc001sgi.1	-	4	366	c.328G>A	c.(328-330)GTG>ATG	p.V110M		NM_033277	NP_150593	Q9GZZ8	LACRT_HUMAN	lacritin precursor	110					calcineurin-NFAT signaling pathway|positive regulation of epithelial cell proliferation|positive regulation of NFAT protein import into nucleus|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of secretion|protein localization in Golgi apparatus|tear secretion	extracellular region|stored secretory granule	collagen binding|fibronectin binding|glycoprotein binding|growth factor activity|laminin-1 binding|protein N-terminus binding			central_nervous_system(1)	1																		---	---	---	---
OR6C4	341418	broad.mit.edu	37	12	55945010	55945010	+	5'Flank	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:55945010A>G	uc010spp.1	+							NM_001005494	NP_001005494			olfactory receptor, family 6, subfamily C,						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0																		---	---	---	---
DGKA	1606	broad.mit.edu	37	12	56333930	56333930	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56333930T>C	uc001sij.2	+	10	1038	c.774T>C	c.(772-774)TAT>TAC	p.Y258Y	DGKA_uc009zoc.1_Silent_p.Y258Y|DGKA_uc001sih.1_Silent_p.Y146Y|DGKA_uc001sii.1_Silent_p.Y116Y|DGKA_uc009zod.1_Silent_p.Y177Y|DGKA_uc009zoe.1_3'UTR|DGKA_uc001sik.2_Silent_p.Y258Y|DGKA_uc001sil.2_Silent_p.Y258Y|DGKA_uc001sim.2_Silent_p.Y258Y|DGKA_uc001sin.2_Silent_p.Y258Y|DGKA_uc009zof.2_Intron|DGKA_uc001sio.2_Missense_Mutation_p.M1T	NM_001345	NP_001336	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	258					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			ovary(3)|pancreas(1)	4					Vitamin E(DB00163)											OREG0021913	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
ERBB3	2065	broad.mit.edu	37	12	56489571	56489571	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56489571G>A	uc001sjh.2	+	17	2229	c.2036G>A	c.(2035-2037)CGA>CAA	p.R679Q	ERBB3_uc009zoj.2_Intron|ERBB3_uc010sqb.1_Missense_Mutation_p.R36Q|ERBB3_uc010sqc.1_Missense_Mutation_p.R620Q|ERBB3_uc009zok.2_Missense_Mutation_p.R121Q|ERBB3_uc001sjk.2_5'Flank	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	679	Cytoplasmic (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)															---	---	---	---
ANKRD52	283373	broad.mit.edu	37	12	56642611	56642611	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56642611G>A	uc001skm.3	-	16	1726	c.1636C>T	c.(1636-1638)CGG>TGG	p.R546W		NM_173595	NP_775866	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	546							protein binding			ovary(2)	2																		---	---	---	---
MYO1A	4640	broad.mit.edu	37	12	57435035	57435035	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57435035T>A	uc001smw.3	-	14	1445	c.1202A>T	c.(1201-1203)AAT>ATT	p.N401I	MYO1A_uc010sqz.1_Missense_Mutation_p.N239I|MYO1A_uc009zpd.2_Missense_Mutation_p.N401I	NM_005379	NP_005370	Q9UBC5	MYO1A_HUMAN	myosin IA	401	Myosin head-like.				sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|urinary_tract(1)	7																		---	---	---	---
ARHGAP9	64333	broad.mit.edu	37	12	57871291	57871291	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57871291A>G	uc001sod.2	-	7	1113	c.920T>C	c.(919-921)CTG>CCG	p.L307P	ARHGAP9_uc001sny.2_5'Flank|ARHGAP9_uc001snz.2_Missense_Mutation_p.L52P|ARHGAP9_uc001soa.2_5'UTR|ARHGAP9_uc001sob.2_Missense_Mutation_p.L236P|ARHGAP9_uc001soc.2_Missense_Mutation_p.L236P|ARHGAP9_uc001soe.1_Missense_Mutation_p.L315P|ARHGAP9_uc010sro.1_Missense_Mutation_p.L236P	NM_032496	NP_115885	Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9 isoform 1	236	WW.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			lung(1)	1			GBM - Glioblastoma multiforme(3;3.37e-34)															---	---	---	---
DCTN2	10540	broad.mit.edu	37	12	57924555	57924555	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57924555G>A	uc001som.1	-	14	1255	c.1123C>T	c.(1123-1125)CAG>TAG	p.Q375*	DCTN2_uc009zpu.1_Nonsense_Mutation_p.Q380*|DCTN2_uc009zpv.1_Nonsense_Mutation_p.Q288*|DCTN2_uc009zpw.1_Nonsense_Mutation_p.Q288*|DCTN2_uc001soo.1_RNA|DCTN2_uc001son.1_Nonsense_Mutation_p.Q288*|DCTN2_uc001sop.1_Nonsense_Mutation_p.Q288*|DCTN2_uc001soq.1_RNA|DCTN2_uc009zpx.1_Nonsense_Mutation_p.Q351*	NM_006400	NP_006391	Q13561	DCTN2_HUMAN	dynactin 2	375					cell proliferation|G2/M transition of mitotic cell cycle|mitosis	centrosome|cytosol|dynactin complex|dynein complex|kinetochore|membrane|microtubule|vesicle	motor activity|protein binding			ovary(1)	1																		---	---	---	---
METTL1	4234	broad.mit.edu	37	12	58162865	58162865	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:58162865C>A	uc010ssd.1	-	6	793	c.745G>T	c.(745-747)GGG>TGG	p.G249W	CYP27B1_uc001spz.1_5'Flank|CYP27B1_uc001sqa.1_5'Flank|METTL1_uc009zqc.2_3'UTR	NM_005371	NP_005362	Q9UBP6	TRMB_HUMAN	methyltransferase-like protein 1 isoform a	249						cytoplasm|nucleus	protein binding|tRNA (guanine-N7-)-methyltransferase activity|tRNA binding				0	all_cancers(7;6.73e-81)|Lung NSC(6;1.07e-25)|all_lung(6;8.25e-24)|all_epithelial(6;4.6e-17)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.211)															---	---	---	---
MON2	23041	broad.mit.edu	37	12	62943509	62943509	+	Missense_Mutation	SNP	A	G	G	rs71465159		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:62943509A>G	uc001sre.2	+	23	3206	c.2815A>G	c.(2815-2817)ACA>GCA	p.T939A	MON2_uc009zqj.2_Missense_Mutation_p.T939A|MON2_uc010ssl.1_Missense_Mutation_p.T867A|MON2_uc010ssm.1_Missense_Mutation_p.T916A|MON2_uc010ssn.1_Missense_Mutation_p.T939A|MON2_uc001srf.2_Missense_Mutation_p.T702A	NM_015026	NP_055841	Q7Z3U7	MON2_HUMAN	MON2 homolog	940					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)														---	---	---	---
MON2	23041	broad.mit.edu	37	12	62954787	62954787	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:62954787T>C	uc001sre.2	+	26	4317	c.3926T>C	c.(3925-3927)GTC>GCC	p.V1309A	MON2_uc009zqj.2_Missense_Mutation_p.V1309A|MON2_uc010ssl.1_Missense_Mutation_p.V1237A|MON2_uc010ssm.1_Missense_Mutation_p.V1286A|MON2_uc010ssn.1_Missense_Mutation_p.V1309A|MON2_uc001srf.2_Missense_Mutation_p.V1072A|MON2_uc001srg.2_Missense_Mutation_p.V184A	NM_015026	NP_055841	Q7Z3U7	MON2_HUMAN	MON2 homolog	1310					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)														---	---	---	---
XPOT	11260	broad.mit.edu	37	12	64812728	64812728	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:64812728A>G	uc001ssb.2	+	6	769	c.343A>G	c.(343-345)ACA>GCA	p.T115A	XPOT_uc009zqm.1_Missense_Mutation_p.T25A	NM_007235	NP_009166	O43592	XPOT_HUMAN	tRNA exportin	115	Necessary for interaction with Ran, nuclear localization and nuclear import.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(28;0.0404)														---	---	---	---
XPOT	11260	broad.mit.edu	37	12	64812733	64812733	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:64812733G>A	uc001ssb.2	+	6	774	c.348G>A	c.(346-348)GAG>GAA	p.E116E	XPOT_uc009zqm.1_Silent_p.E26E	NM_007235	NP_009166	O43592	XPOT_HUMAN	tRNA exportin	116	Necessary for interaction with Ran, nuclear localization and nuclear import.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(28;0.0404)														---	---	---	---
XPOT	11260	broad.mit.edu	37	12	64812808	64812808	+	Silent	SNP	C	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:64812808C>G	uc001ssb.2	+	6	849	c.423C>G	c.(421-423)CTC>CTG	p.L141L	XPOT_uc009zqm.1_Silent_p.L51L	NM_007235	NP_009166	O43592	XPOT_HUMAN	tRNA exportin	141	Necessary for interaction with Ran, nuclear localization and nuclear import.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(28;0.0404)														---	---	---	---
RAP1B	5908	broad.mit.edu	37	12	69050939	69050939	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:69050939G>A	uc001sub.2	+	7	690	c.527G>A	c.(526-528)CGC>CAC	p.R176H	RAP1B_uc010ste.1_Missense_Mutation_p.R110H|RAP1B_uc001suc.2_Missense_Mutation_p.R176H|RAP1B_uc010stf.1_Missense_Mutation_p.R157H|RAP1B_uc010stg.1_Missense_Mutation_p.R134H|RAP1B_uc010sth.1_Missense_Mutation_p.R134H|RAP1B_uc010sti.1_Missense_Mutation_p.R129H	NM_001089704	NP_001083173	P61224	RAP1B_HUMAN	SubName: Full=Ras-related protein Rap-1A; SubName: Full=cDNA FLJ75985, highly similar to Homo sapiens RAP1A, member of RAS oncogene family (RAP1A), transcript variant 2, mRNA; SubName: Full=RAP1A, member of RAS oncogene family;	176					blood coagulation|energy reserve metabolic process|regulation of establishment of cell polarity|regulation of insulin secretion	cell-cell junction|cytosol	GDP binding|GTP binding|GTPase activity|protein binding				0	Breast(13;1.24e-05)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)	GBM - Glioblastoma multiforme(7;0.000306)														---	---	---	---
RAB3IP	117177	broad.mit.edu	37	12	70149312	70149312	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:70149312C>T	uc001svp.2	+	2	619	c.172C>T	c.(172-174)CGG>TGG	p.R58W	RAB3IP_uc001svl.1_Missense_Mutation_p.R42W|RAB3IP_uc001svm.2_Missense_Mutation_p.R42W|RAB3IP_uc001svn.2_Missense_Mutation_p.R42W|RAB3IP_uc001svo.2_RNA|RAB3IP_uc001svq.2_Missense_Mutation_p.R58W|RAB3IP_uc001svr.2_RNA|RAB3IP_uc001svs.2_RNA	NM_175623	NP_783322	Q96QF0	RAB3I_HUMAN	RAB3A interacting protein isoform alpha 2	58					cilium assembly|Golgi to plasma membrane transport|protein localization to organelle|protein transport	actin cortical patch|centrosome|cytosol|lamellipodium|microtubule basal body|nucleus	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1	Esophageal squamous(21;0.187)		Lung(24;0.000381)|OV - Ovarian serous cystadenocarcinoma(12;0.00168)|STAD - Stomach adenocarcinoma(21;0.00694)															---	---	---	---
NAP1L1	4673	broad.mit.edu	37	12	76453978	76453978	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:76453978A>G	uc001sxw.2	-	5	700	c.288T>C	c.(286-288)TAT>TAC	p.Y96Y	NAP1L1_uc001sxv.2_Silent_p.Y54Y|NAP1L1_uc001sxz.2_Silent_p.Y54Y|NAP1L1_uc001sxx.2_Silent_p.Y96Y|NAP1L1_uc001sxy.2_Silent_p.Y33Y|NAP1L1_uc010sty.1_Silent_p.Y54Y|NAP1L1_uc010stz.1_5'UTR|NAP1L1_uc010sua.1_Silent_p.Y96Y|NAP1L1_uc001syb.2_Silent_p.Y96Y|NAP1L1_uc001sya.2_Silent_p.Y54Y|NAP1L1_uc001syc.2_Silent_p.Y96Y	NM_139207	NP_631946	P55209	NP1L1_HUMAN	nucleosome assembly protein 1-like 1	96					DNA replication|nucleosome assembly|positive regulation of cell proliferation	chromatin assembly complex|melanosome	protein binding			ovary(1)|skin(1)	2		Colorectal(145;0.09)																---	---	---	---
NAV3	89795	broad.mit.edu	37	12	78513556	78513556	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:78513556G>A	uc001syp.2	+	15	3753	c.3580G>A	c.(3580-3582)GTC>ATC	p.V1194I	NAV3_uc001syo.2_Missense_Mutation_p.V1194I|NAV3_uc010sub.1_Missense_Mutation_p.V694I|NAV3_uc009zsf.2_Missense_Mutation_p.V202I	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1194	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17															HNSCC(70;0.22)			---	---	---	---
PPFIA2	8499	broad.mit.edu	37	12	81688718	81688718	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:81688718T>C	uc001szo.1	-	24	2982	c.2821A>G	c.(2821-2823)AGA>GGA	p.R941G	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	867										ovary(3)|lung(2)|pancreas(1)	6																		---	---	---	---
PPFIA2	8499	broad.mit.edu	37	12	81839401	81839401	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:81839401G>T	uc001szo.1	-	6	665	c.504C>A	c.(502-504)TCC>TCA	p.S168S	PPFIA2_uc010sue.1_Silent_p.S68S|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	94										ovary(3)|lung(2)|pancreas(1)	6																		---	---	---	---
SLC6A15	55117	broad.mit.edu	37	12	85277601	85277601	+	Intron	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:85277601T>C	uc001szv.2	-						SLC6A15_uc010sul.1_Intron|SLC6A15_uc001szy.2_Missense_Mutation_p.T265A	NM_182767	NP_877499			solute carrier family 6, member 15 isoform 1						cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			pancreas(2)|ovary(1)	3																		---	---	---	---
CCDC41	51134	broad.mit.edu	37	12	94772812	94772812	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:94772812T>C	uc001tdd.2	-	7	1142	c.556A>G	c.(556-558)AGA>GGA	p.R186G	CCDC41_uc001tde.2_Missense_Mutation_p.R186G|CCDC41_uc009zsw.1_RNA|CCDC41_uc001tdf.2_Missense_Mutation_p.R186G	NM_016122	NP_057206	Q9Y592	CCD41_HUMAN	NY-REN-58 antigen	178	Potential.										0																		---	---	---	---
FGD6	55785	broad.mit.edu	37	12	95486488	95486488	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:95486488C>A	uc001tdp.3	-	16	3958	c.3734G>T	c.(3733-3735)CGG>CTG	p.R1245L	FGD6_uc009zsx.2_Missense_Mutation_p.R378L|FGD6_uc001tdq.1_Missense_Mutation_p.R281L	NM_018351	NP_060821	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	1245	FYVE-type.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|breast(1)	3																		---	---	---	---
CCDC38	120935	broad.mit.edu	37	12	96288828	96288828	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:96288828T>C	uc001tek.1	-	8	945	c.711A>G	c.(709-711)GCA>GCG	p.A237A		NM_182496	NP_872302	Q502W7	CCD38_HUMAN	coiled-coil domain containing 38	237										skin(1)	1																		---	---	---	---
IKBIP	121457	broad.mit.edu	37	12	99007899	99007899	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:99007899T>C	uc001tfv.2	-	3	627	c.517A>G	c.(517-519)ACA>GCA	p.T173A	IKBIP_uc001tfw.2_3'UTR	NM_201612	NP_963906	Q70UQ0	IKIP_HUMAN	IKK interacting protein isoform 2	173					induction of apoptosis|response to X-ray	endoplasmic reticulum membrane|integral to membrane	protein binding				0																		---	---	---	---
GAS2L3	283431	broad.mit.edu	37	12	100994275	100994275	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:100994275C>T	uc001thu.2	+	4	360	c.134C>T	c.(133-135)GCC>GTC	p.A45V	GAS2L3_uc009zty.2_Missense_Mutation_p.A45V|GAS2L3_uc001thv.2_5'UTR	NM_174942	NP_777602	Q86XJ1	GA2L3_HUMAN	growth arrest-specific 2 like 3	45					cell cycle arrest					skin(1)	1																		---	---	---	---
NT5DC3	51559	broad.mit.edu	37	12	104200659	104200659	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:104200659G>A	uc010swe.1	-	3	483	c.442C>T	c.(442-444)CGT>TGT	p.R148C		NM_001031701	NP_001026871	Q86UY8	NT5D3_HUMAN	5'-nucleotidase domain containing 3	148							hydrolase activity|metal ion binding			ovary(2)|skin(1)	3																		---	---	---	---
ASCL4	121549	broad.mit.edu	37	12	108169229	108169229	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:108169229C>T	uc001tmr.2	+	1	1068	c.237C>T	c.(235-237)AAC>AAT	p.N79N		NM_203436	NP_982260	Q6XD76	ASCL4_HUMAN	achaete-scute complex-like 4	78	Basic motif.				regulation of transcription from RNA polymerase II promoter|skin development|transcription, DNA-dependent	nucleus	DNA binding			central_nervous_system(1)	1																		---	---	---	---
DAO	1610	broad.mit.edu	37	12	109278888	109278888	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:109278888G>A	uc001tnr.3	+	2	259	c.106G>A	c.(106-108)GCG>ACG	p.A36T	DAO_uc001tnq.3_Missense_Mutation_p.A36T|DAO_uc009zvb.2_RNA|DAO_uc001tns.3_RNA	NM_001917	NP_001908	P14920	OXDA_HUMAN	D-amino-acid oxidase	36					glyoxylate metabolic process	peroxisomal matrix	binding|D-amino-acid oxidase activity			ovary(1)|skin(1)	2																		---	---	---	---
ACACB	32	broad.mit.edu	37	12	109702084	109702084	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:109702084C>T	uc001tob.2	+	50	6954	c.6835C>T	c.(6835-6837)CTA>TTA	p.L2279L	ACACB_uc001toc.2_Silent_p.L2279L|ACACB_uc010sxl.1_RNA|ACACB_uc001tod.2_RNA|ACACB_uc010sxm.1_Silent_p.L945L	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	2279	Carboxyltransferase.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)											OREG0022102	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
TRPV4	59341	broad.mit.edu	37	12	110232159	110232159	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:110232159G>A	uc001tpj.1	-	7	1561	c.1466C>T	c.(1465-1467)GCC>GTC	p.A489V	TRPV4_uc001tpg.1_Missense_Mutation_p.A455V|TRPV4_uc001tph.1_Missense_Mutation_p.A442V|TRPV4_uc001tpi.1_Missense_Mutation_p.A382V|TRPV4_uc001tpk.1_Missense_Mutation_p.A489V|TRPV4_uc001tpl.1_Missense_Mutation_p.A429V	NM_021625	NP_067638	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel,	489	Extracellular (Potential).				actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4																		---	---	---	---
TRPV4	59341	broad.mit.edu	37	12	110240832	110240832	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:110240832A>G	uc001tpj.1	-	3	771	c.676T>C	c.(676-678)TTC>CTC	p.F226L	TRPV4_uc001tpg.1_Missense_Mutation_p.F192L|TRPV4_uc001tph.1_Missense_Mutation_p.F226L|TRPV4_uc001tpi.1_Missense_Mutation_p.F226L|TRPV4_uc001tpk.1_Missense_Mutation_p.F226L|TRPV4_uc001tpl.1_Missense_Mutation_p.F226L	NM_021625	NP_067638	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel,	226	Cytoplasmic (Potential).				actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4																		---	---	---	---
GLTP	51228	broad.mit.edu	37	12	110293442	110293442	+	Silent	SNP	G	A	A	rs138733952		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:110293442G>A	uc001tpm.2	-	4	543	c.429C>T	c.(427-429)ATC>ATT	p.I143I	GLTP_uc010sxt.1_RNA	NM_016433	NP_057517	Q9NZD2	GLTP_HUMAN	glycolipid transfer protein	143						cytoplasm	glycolipid binding|glycolipid transporter activity				0		Lung NSC(355;2.38e-06)|Breast(359;0.00354)|Myeloproliferative disorder(1001;0.0122)		BRCA - Breast invasive adenocarcinoma(302;0.0025)														---	---	---	---
CUX2	23316	broad.mit.edu	37	12	111652122	111652122	+	Intron	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:111652122A>G	uc001tsa.1	+						CUX2_uc001tsb.1_Intron	NM_015267	NP_056082			cut-like 2							nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6																		---	---	---	---
TBX5	6910	broad.mit.edu	37	12	114839626	114839626	+	Intron	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:114839626C>A	uc001tvo.2	-						TBX5_uc001tvp.2_Intron|TBX5_uc001tvq.2_Intron|TBX5_uc010syv.1_Intron	NM_181486	NP_852259			T-box 5 isoform 1						cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)														---	---	---	---
SUDS3	64426	broad.mit.edu	37	12	118841306	118841306	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:118841306T>C	uc001twz.2	+	10	926	c.787T>C	c.(787-789)TAC>CAC	p.Y263H		NM_022491	NP_071936	Q9H7L9	SDS3_HUMAN	suppressor of defective silencing 3	263					chromatin modification|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	Sin3 complex	histone deacetylase binding				0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)																	---	---	---	---
GCN1L1	10985	broad.mit.edu	37	12	120567103	120567103	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:120567103G>A	uc001txo.2	-	57	7880	c.7867C>T	c.(7867-7869)CGG>TGG	p.R2623W		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	2623	HEAT 24.				regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)																	---	---	---	---
PXN	5829	broad.mit.edu	37	12	120654873	120654873	+	Intron	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:120654873G>T	uc001txt.2	-						PXN_uc001txu.2_5'UTR|PXN_uc001txv.2_Intron|PXN_uc001txx.2_Intron|PXN_uc001txy.2_Intron|PXN_uc001txz.2_RNA	NM_001080855	NP_001074324			paxillin isoform 1						cell junction assembly|cell-matrix adhesion|cellular response to reactive oxygen species|epidermal growth factor receptor signaling pathway|growth hormone receptor signaling pathway|muscle contraction|signal complex assembly	cytoplasm|focal adhesion|lamellipodium|microtubule associated complex	beta-catenin binding|vinculin binding|zinc ion binding			ovary(1)|breast(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)																	---	---	---	---
PXN	5829	broad.mit.edu	37	12	120660799	120660799	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:120660799G>A	uc001txt.2	-	4	491	c.360C>T	c.(358-360)TTC>TTT	p.F120F	PXN_uc001txv.2_5'UTR|PXN_uc001txx.2_5'UTR|PXN_uc001txy.2_Silent_p.F120F|PXN_uc001txz.2_RNA|uc001tya.2_5'Flank	NM_001080855	NP_001074324	P49023	PAXI_HUMAN	paxillin isoform 1	120					cell junction assembly|cell-matrix adhesion|cellular response to reactive oxygen species|epidermal growth factor receptor signaling pathway|growth hormone receptor signaling pathway|muscle contraction|signal complex assembly	cytoplasm|focal adhesion|lamellipodium|microtubule associated complex	beta-catenin binding|vinculin binding|zinc ion binding			ovary(1)|breast(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)																	---	---	---	---
GATC	283459	broad.mit.edu	37	12	120894950	120894950	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:120894950G>A	uc010szi.1	+	3	326	c.326G>A	c.(325-327)CGC>CAC	p.R109H		NM_176818	NP_789788	O43716	GATCL_HUMAN	glutamyl-tRNA(Gln) amidotransferase, subunit C	109					regulation of translational fidelity						0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)															OREG0022192	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
RHOF	54509	broad.mit.edu	37	12	122219030	122219030	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:122219030C>T	uc001ubb.2	-	3	350	c.295G>A	c.(295-297)GAC>AAC	p.D99N	TMEM120B_uc001ubc.3_3'UTR|TMEM120B_uc009zxh.2_3'UTR|TMEM120B_uc001uba.1_RNA|RHOF_uc001ubd.3_Missense_Mutation_p.D99N	NM_019034	NP_061907	Q9HBH0	RHOF_HUMAN	ras homolog gene family, member F precursor	99					actin filament organization|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity			ovary(1)	1	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;4.38e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.223)														---	---	---	---
WDR66	144406	broad.mit.edu	37	12	122395142	122395142	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:122395142C>G	uc009zxk.2	+	11	1840	c.1698C>G	c.(1696-1698)GAC>GAG	p.D566E		NM_144668	NP_653269	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	566							calcium ion binding			ovary(1)|skin(1)	2	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)														---	---	---	---
KNTC1	9735	broad.mit.edu	37	12	123073263	123073263	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:123073263T>C	uc001ucv.2	+	40	4062	c.3899T>C	c.(3898-3900)TTT>TCT	p.F1300S	KNTC1_uc010taf.1_Intron	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	1300					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)														---	---	---	---
HIP1R	9026	broad.mit.edu	37	12	123333393	123333393	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:123333393C>T	uc001udj.1	+	4	410	c.351C>T	c.(349-351)GAC>GAT	p.D117D	HIP1R_uc001udg.1_Silent_p.D105D|HIP1R_uc001udi.1_Silent_p.D117D|HIP1R_uc001udh.2_Silent_p.D117D	NM_003959	NP_003950	O75146	HIP1R_HUMAN	huntingtin interacting protein-1-related	117	ENTH.				receptor-mediated endocytosis	clathrin coated vesicle membrane|coated pit|perinuclear region of cytoplasm	actin binding|phosphatidylinositol binding			ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;4.6e-05)|Epithelial(86;0.000119)|BRCA - Breast invasive adenocarcinoma(302;0.2)														---	---	---	---
MPHOSPH9	10198	broad.mit.edu	37	12	123706165	123706165	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:123706165A>G	uc001uel.2	-	1	277	c.170T>C	c.(169-171)CTG>CCG	p.L57P	MPHOSPH9_uc010tal.1_5'UTR|MPHOSPH9_uc010tam.1_RNA|MPHOSPH9_uc001uem.2_5'UTR	NM_022782	NP_073619	Q99550	MPP9_HUMAN	M-phase phosphoprotein 9	57					M phase of mitotic cell cycle	centriole|Golgi membrane					0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000182)|Epithelial(86;0.00046)|BRCA - Breast invasive adenocarcinoma(302;0.169)														---	---	---	---
SNRNP35	11066	broad.mit.edu	37	12	123950369	123950369	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:123950369C>T	uc001ufb.1	+	2	398	c.282C>T	c.(280-282)TAC>TAT	p.Y94Y	SNRNP35_uc010tar.1_Silent_p.Y99Y|SNRNP35_uc009zxz.2_Silent_p.Y99Y|SNRNP35_uc001ufc.1_Intron	NM_022717	NP_073208	Q16560	U1SBP_HUMAN	small nuclear ribonucleoprotein 35kDa (U11/U12)	94	RRM.				mRNA processing	U12-type spliceosomal complex	nucleotide binding|RNA binding				0																		---	---	---	---
EIF2B1	1967	broad.mit.edu	37	12	124109418	124109418	+	Intron	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:124109418A>G	uc001ufm.2	-						EIF2B1_uc001ufn.2_Intron	NM_001414	NP_001405			eukaryotic translation initiation factor 2B,						cellular response to stimulus|oligodendrocyte development|regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex|membrane fraction|plasma membrane	protein binding|translation initiation factor activity				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.67e-05)|Epithelial(86;0.000353)|all cancers(50;0.00489)														---	---	---	---
TCTN2	79867	broad.mit.edu	37	12	124191372	124191372	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:124191372T>C	uc001ufp.2	+	16	1997	c.1869T>C	c.(1867-1869)CCT>CCC	p.P623P	TCTN2_uc009zya.2_Silent_p.P622P	NM_024809	NP_079085	Q96GX1	TECT2_HUMAN	tectonic family member 2 isoform 1	623	Extracellular (Potential).				cilium assembly|smoothened signaling pathway	integral to membrane				ovary(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000163)|Epithelial(86;0.000502)|all cancers(50;0.00451)														---	---	---	---
PIWIL1	9271	broad.mit.edu	37	12	130846109	130846109	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:130846109G>A	uc001uik.2	+	16	2023	c.1933G>A	c.(1933-1935)GCA>ACA	p.A645T	PIWIL1_uc001uij.1_Missense_Mutation_p.A645T	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	645	RNA-binding (By similarity).|Piwi.				gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)														---	---	---	---
RAN	5901	broad.mit.edu	37	12	131360449	131360449	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:131360449C>A	uc001uir.2	+	7	694	c.629C>A	c.(628-630)CCG>CAG	p.P210Q	RAN_uc010tbk.1_Missense_Mutation_p.P122Q|RAN_uc010tbl.1_Missense_Mutation_p.P122Q|RAN_uc001uis.2_Missense_Mutation_p.P230Q	NM_006325	NP_006316	P62826	RAN_HUMAN	ras-related nuclear protein	210					androgen receptor signaling pathway|cell division|DNA metabolic process|mitosis|mitotic spindle organization|positive regulation of transcription, DNA-dependent|protein export from nucleus|RNA export from nucleus|viral genome transport in host cell|viral infectious cycle	cytosol|melanosome|nuclear pore|nucleoplasm	androgen receptor binding|chromatin binding|GTP binding|GTPase activity|transcription coactivator activity				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	Lung NSC(355;7.46e-07)|all_epithelial(31;7.36e-06)		OV - Ovarian serous cystadenocarcinoma(86;9.18e-49)|Epithelial(86;1.42e-45)|all cancers(50;6.28e-40)														---	---	---	---
POLE	5426	broad.mit.edu	37	12	133201398	133201398	+	Intron	SNP	T	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:133201398T>G	uc001uks.1	-						POLE_uc001ukq.1_Intron|POLE_uc001ukr.1_Intron|POLE_uc010tbq.1_Intron	NM_006231	NP_006222			DNA-directed DNA polymerase epsilon						base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)									DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					---	---	---	---
GOLGA3	2802	broad.mit.edu	37	12	133384887	133384887	+	Silent	SNP	C	A	A	rs3741487	byFrequency;by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:133384887C>A	uc001ukz.1	-	5	1327	c.768G>T	c.(766-768)GCG>GCT	p.A256A	GOLGA3_uc001ula.1_Silent_p.A256A|GOLGA3_uc001ulb.2_Silent_p.A256A	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	256	Golgi-targeting domain.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)														---	---	---	---
EFHA1	221154	broad.mit.edu	37	13	22178154	22178154	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:22178154G>A	uc001uof.2	-	1	156	c.134C>T	c.(133-135)GCA>GTA	p.A45V		NM_152726	NP_689939	Q8IYU8	EFHA1_HUMAN	EF-hand domain family, member A1	45	Ala-rich.						calcium ion binding				0		all_cancers(29;1.24e-15)|all_epithelial(30;5.4e-14)|all_lung(29;2.04e-13)|Lung SC(185;0.0367)		all cancers(112;0.000171)|Epithelial(112;0.000398)|OV - Ovarian serous cystadenocarcinoma(117;0.00641)|Lung(94;0.189)														---	---	---	---
PABPC3	5042	broad.mit.edu	37	13	25670687	25670687	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:25670687T>G	uc001upy.2	+	1	412	c.351T>G	c.(349-351)GAT>GAG	p.D117E		NM_030979	NP_112241	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	117	RRM 2.				mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			ovary(3)|skin(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)														---	---	---	---
NUPL1	9818	broad.mit.edu	37	13	25911075	25911075	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:25911075G>A	uc001uqi.2	+	14	1683	c.1437G>A	c.(1435-1437)GGG>GGA	p.G479G	NUPL1_uc001uqj.2_Silent_p.G467G	NM_014089	NP_054808	Q9BVL2	NUPL1_HUMAN	nucleoporin like 1 isoform a	479	14 X 2 AA repeats of F-G.				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore					0		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.0092)|Epithelial(112;0.0477)|OV - Ovarian serous cystadenocarcinoma(117;0.165)|GBM - Glioblastoma multiforme(144;0.244)														---	---	---	---
SLC46A3	283537	broad.mit.edu	37	13	29286869	29286869	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:29286869C>A	uc001usi.2	-	2	1978	c.1008G>T	c.(1006-1008)ATG>ATT	p.M336I	SLC46A3_uc001usg.2_Missense_Mutation_p.M261I|SLC46A3_uc001usj.2_Missense_Mutation_p.M336I|SLC46A3_uc001ush.2_Missense_Mutation_p.M336I|SLC46A3_uc001usk.2_Missense_Mutation_p.M261I	NM_181785	NP_861450	Q7Z3Q1	S46A3_HUMAN	solute carrier family 46, member 3 isoform a	336	Helical; (Potential).				transmembrane transport	integral to membrane				central_nervous_system(1)|skin(1)	2		Lung SC(185;0.0367)		all cancers(112;0.159)														---	---	---	---
NBEA	26960	broad.mit.edu	37	13	35716483	35716483	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:35716483T>C	uc001uvb.2	+	19	2620	c.2414T>C	c.(2413-2415)GTG>GCG	p.V805A		NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	805						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)														---	---	---	---
MAB21L1	4081	broad.mit.edu	37	13	36049859	36049859	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:36049859C>T	uc001uvc.2	-	1	974	c.417G>A	c.(415-417)GCG>GCA	p.A139A	NBEA_uc001uvb.2_Intron|NBEA_uc010abi.2_Intron|NBEA_uc010tee.1_Intron|NBEA_uc010tef.1_5'Flank|NBEA_uc010teg.1_5'Flank	NM_005584	NP_005575	Q13394	MB211_HUMAN	mab-21-like protein 1	139					anatomical structure morphogenesis	nucleus				ovary(2)	2		Breast(139;0.014)|Lung SC(185;0.051)|Prostate(109;0.202)		all cancers(112;9.63e-08)|Epithelial(112;1.37e-06)|BRCA - Breast invasive adenocarcinoma(63;0.000659)|OV - Ovarian serous cystadenocarcinoma(117;0.00372)|GBM - Glioblastoma multiforme(144;0.115)														---	---	---	---
DCLK1	9201	broad.mit.edu	37	13	36700166	36700166	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:36700166C>T	uc001uvf.2	-	2	342	c.109G>A	c.(109-111)GCC>ACC	p.A37T		NM_004734	NP_004725	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	37					cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			stomach(6)|ovary(2)|skin(1)	9		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)														---	---	---	---
C13orf36	400120	broad.mit.edu	37	13	37269461	37269461	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:37269461C>T	uc001uvt.3	+	2	692	c.246C>T	c.(244-246)GAC>GAT	p.D82D		NM_203451	NP_982276	A2A2V5	CM036_HUMAN	hypothetical protein LOC400120	82						integral to membrane				skin(1)	1																		---	---	---	---
POSTN	10631	broad.mit.edu	37	13	38160400	38160400	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:38160400C>T	uc001uwo.3	-	7	889	c.771G>A	c.(769-771)TCG>TCA	p.S257S	POSTN_uc001uwp.3_Silent_p.S257S|POSTN_uc001uwr.2_Silent_p.S257S|POSTN_uc001uwq.2_Silent_p.S257S|POSTN_uc010teu.1_Silent_p.S257S|POSTN_uc010tev.1_Silent_p.S257S|POSTN_uc010tew.1_Silent_p.S257S|POSTN_uc010tex.1_Silent_p.S172S	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1	257	FAS1 2.				cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)														---	---	---	---
KBTBD6	89890	broad.mit.edu	37	13	41706053	41706053	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:41706053T>C	uc001uxu.1	-	1	884	c.595A>G	c.(595-597)AAC>GAC	p.N199D	KBTBD6_uc010ace.1_Intron|KBTBD6_uc010tfe.1_Missense_Mutation_p.N133D|uc001uxv.1_5'Flank	NM_152903	NP_690867	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain-containing 6	199							protein binding			ovary(1)|skin(1)	2		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)														---	---	---	---
DGKH	160851	broad.mit.edu	37	13	42780166	42780166	+	Intron	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:42780166A>G	uc001uyl.1	+						DGKH_uc010tfh.1_Intron|DGKH_uc001uym.1_Intron|DGKH_uc010tfi.1_Intron|DGKH_uc010tfj.1_Intron|DGKH_uc001uyn.1_Intron|DGKH_uc001uyo.1_Intron|DGKH_uc001uyp.2_Intron	NM_178009	NP_821077			diacylglycerol kinase, eta isoform 2						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation|protein oligomerization	endosome|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(2)	2		Lung NSC(96;1.02e-05)|Prostate(109;0.0168)|Lung SC(185;0.0262)|Breast(139;0.0709)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;5.88e-05)|GBM - Glioblastoma multiforme(144;0.000935)|BRCA - Breast invasive adenocarcinoma(63;0.109)														---	---	---	---
AKAP11	11215	broad.mit.edu	37	13	42876041	42876041	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:42876041A>G	uc001uys.1	+	8	3334	c.3159A>G	c.(3157-3159)ACA>ACG	p.T1053T		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	1053					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)														---	---	---	---
ENOX1	55068	broad.mit.edu	37	13	43934001	43934001	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:43934001G>A	uc001uza.3	-	7	875	c.575C>T	c.(574-576)GCC>GTC	p.A192V	ENOX1_uc001uzb.3_Missense_Mutation_p.A192V|ENOX1_uc001uzc.3_Missense_Mutation_p.A192V|ENOX1_uc010tfm.1_Missense_Mutation_p.A5V	NM_001127615	NP_001121087	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	192	RRM.				electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			pancreas(1)|skin(1)	2		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)														---	---	---	---
SPERT	220082	broad.mit.edu	37	13	46287374	46287374	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:46287374G>A	uc001van.1	+	3	294	c.214G>A	c.(214-216)GCG>ACG	p.A72T	SPERT_uc001vao.2_Missense_Mutation_p.A36T	NM_152719	NP_689932	Q8NA61	SPERT_HUMAN	spermatid associated	72						cytoplasmic membrane-bounded vesicle				central_nervous_system(1)|pancreas(1)	2		Breast(56;0.000819)|Lung NSC(96;0.00227)|Prostate(109;0.00703)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.26e-05)														---	---	---	---
SPERT	220082	broad.mit.edu	37	13	46287395	46287395	+	Missense_Mutation	SNP	C	T	T	rs149478922		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:46287395C>T	uc001van.1	+	3	315	c.235C>T	c.(235-237)CGG>TGG	p.R79W	SPERT_uc001vao.2_Missense_Mutation_p.R43W	NM_152719	NP_689932	Q8NA61	SPERT_HUMAN	spermatid associated	79						cytoplasmic membrane-bounded vesicle				central_nervous_system(1)|pancreas(1)	2		Breast(56;0.000819)|Lung NSC(96;0.00227)|Prostate(109;0.00703)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.26e-05)														---	---	---	---
RB1	5925	broad.mit.edu	37	13	48919305	48919305	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:48919305T>C	uc001vcb.2	+	4	636	c.470T>C	c.(469-471)GTA>GCA	p.V157A	RB1_uc010acs.1_Intron	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	157					androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(5)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			---	---	---	---
SETDB2	83852	broad.mit.edu	37	13	50062611	50062611	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:50062611C>T	uc001vcz.2	+	13	2704	c.1798C>T	c.(1798-1800)CGA>TGA	p.R600*	SETDB2_uc010adh.2_3'UTR|SETDB2_uc001vda.2_Nonsense_Mutation_p.R588*	NM_031915	NP_114121	Q96T68	SETB2_HUMAN	SET domain, bifurcated 2 isoform a	600	SET.				cell division|chromosome segregation|heart looping|left/right axis specification|mitosis|negative regulation of transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone methyltransferase activity (H3-K9 specific)|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;0.000408)|Breast(56;0.00131)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;3.1e-09)														---	---	---	---
FAM124A	220108	broad.mit.edu	37	13	51854685	51854685	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:51854685A>G	uc001vfg.1	+	4	1065	c.934A>G	c.(934-936)AGC>GGC	p.S312G	FAM124A_uc001vff.1_Missense_Mutation_p.S348G	NM_145019	NP_659456	Q86V42	F124A_HUMAN	hypothetical protein LOC220108	312										central_nervous_system(1)	1		Acute lymphoblastic leukemia(7;0.000334)|Breast(56;0.00156)|Prostate(109;0.00538)|Lung NSC(96;0.0216)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;4.25e-07)														---	---	---	---
UTP14C	9724	broad.mit.edu	37	13	52603377	52603377	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:52603377T>C	uc001vgb.2	+	2	972	c.437T>C	c.(436-438)ATC>ACC	p.I146T	UTP14C_uc001vga.2_3'UTR|UTP14C_uc001vgc.2_RNA	NM_021645	NP_067677	Q5TAP6	UT14C_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein,	146					cell differentiation|meiosis|multicellular organismal development|rRNA processing|spermatogenesis	nucleolus|small-subunit processome				ovary(3)|large_intestine(1)|breast(1)	5		Breast(56;0.00173)|Lung NSC(96;0.0108)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.3e-08)														---	---	---	---
PCDH8	5100	broad.mit.edu	37	13	53418897	53418897	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:53418897T>C	uc001vhi.2	-	3	3214	c.3011A>G	c.(3010-3012)TAC>TGC	p.Y1004C	PCDH8_uc001vhj.2_Missense_Mutation_p.Y907C	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	1004	Cytoplasmic (Potential).				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)														---	---	---	---
PCDH8	5100	broad.mit.edu	37	13	53420526	53420526	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:53420526G>A	uc001vhi.2	-	1	2249	c.2046C>T	c.(2044-2046)CCC>CCT	p.P682P	PCDH8_uc001vhj.2_Silent_p.P682P	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	682	Extracellular (Potential).|Cadherin 6.				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)														---	---	---	---
PCDH20	64881	broad.mit.edu	37	13	61987878	61987878	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:61987878G>T	uc001vid.3	-	2	718	c.354C>A	c.(352-354)TCC>TCA	p.S118S	PCDH20_uc010thj.1_Silent_p.S118S	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	91	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)														---	---	---	---
MYCBP2	23077	broad.mit.edu	37	13	77672481	77672481	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:77672481G>A	uc001vkf.2	-	57	8785	c.8694C>T	c.(8692-8694)TGC>TGT	p.C2898C	MYCBP2_uc010aev.2_Silent_p.C2302C|MYCBP2_uc001vkg.1_Silent_p.C421C|MYCBP2_uc010aew.2_Silent_p.C284C	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	2898					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)														---	---	---	---
MYCBP2	23077	broad.mit.edu	37	13	77718664	77718664	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:77718664T>C	uc001vkf.2	-	50	7196	c.7105A>G	c.(7105-7107)AAT>GAT	p.N2369D	MYCBP2_uc010aev.2_Missense_Mutation_p.N1773D	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	2369	Filamin.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)														---	---	---	---
MYCBP2	23077	broad.mit.edu	37	13	77738662	77738662	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:77738662C>A	uc001vkf.2	-	44	6451	c.6360G>T	c.(6358-6360)TTG>TTT	p.L2120F	MYCBP2_uc010aev.2_Missense_Mutation_p.L1524F	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	2120					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)														---	---	---	---
MYCBP2	23077	broad.mit.edu	37	13	77900654	77900654	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:77900654T>A	uc001vkf.2	-	2	234	c.143A>T	c.(142-144)AAT>ATT	p.N48I	MYCBP2_uc010aev.2_5'UTR	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	48					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)														---	---	---	---
SLITRK1	114798	broad.mit.edu	37	13	84453749	84453749	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:84453749C>T	uc001vlk.2	-	1	2780	c.1894G>A	c.(1894-1896)GCC>ACC	p.A632T		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	632	Helical; (Potential).					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)														---	---	---	---
SLITRK1	114798	broad.mit.edu	37	13	84455314	84455314	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:84455314C>A	uc001vlk.2	-	1	1215	c.329G>T	c.(328-330)AGG>ATG	p.R110M		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	110	Extracellular (Potential).|LRR 3.					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)														---	---	---	---
GPC6	10082	broad.mit.edu	37	13	95034795	95034795	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:95034795G>T	uc001vlt.2	+	7	1912	c.1280G>T	c.(1279-1281)AGC>ATC	p.S427I		NM_005708	NP_005699	Q9Y625	GPC6_HUMAN	glypican 6 precursor	427						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)																---	---	---	---
LIG4	3981	broad.mit.edu	37	13	108862651	108862651	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:108862651A>G	uc001vqn.2	-	2	1239	c.966T>C	c.(964-966)GAT>GAC	p.D322D	LIG4_uc001vqo.2_Silent_p.D322D|LIG4_uc010agg.1_Silent_p.D255D|LIG4_uc010agf.2_Silent_p.D322D|LIG4_uc001vqp.2_Silent_p.D322D	NM_002312	NP_002303	P49917	DNLI4_HUMAN	DNA ligase IV	322					cell cycle|cell division|cell proliferation|central nervous system development|chromosome organization|DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|DNA replication|double-strand break repair via nonhomologous end joining|in utero embryonic development|initiation of viral infection|isotype switching|negative regulation of neuron apoptosis|neuron apoptosis|nucleotide-excision repair, DNA gap filling|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|pro-B cell differentiation|provirus integration|response to gamma radiation|response to X-ray|single strand break repair|somatic stem cell maintenance|T cell differentiation in thymus|T cell receptor V(D)J recombination	condensed chromosome|cytoplasm|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|focal adhesion|nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding|protein C-terminus binding				0	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)												NHEJ					---	---	---	---
ATP11A	23250	broad.mit.edu	37	13	113526106	113526106	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:113526106A>G	uc001vsi.3	+	26	3137	c.3049A>G	c.(3049-3051)ACA>GCA	p.T1017A	ATP11A_uc001vsj.3_Missense_Mutation_p.T1017A|ATP11A_uc010ago.2_RNA	NM_015205	NP_056020	P98196	AT11A_HUMAN	ATPase, class VI, type 11A isoform a	1017	Helical; (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)																---	---	---	---
PCID2	55795	broad.mit.edu	37	13	113851504	113851504	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:113851504G>A	uc010tju.1	-	4	335	c.254C>T	c.(253-255)ACC>ATC	p.T85I	PCID2_uc010tjv.1_Missense_Mutation_p.T85I|PCID2_uc010tjw.1_Missense_Mutation_p.T85I|PCID2_uc001vte.2_5'UTR|PCID2_uc001vtd.2_5'UTR|PCID2_uc001vtf.2_5'UTR|PCID2_uc001vtg.1_RNA	NM_001127203	NP_001120675	Q5JVF3	PCID2_HUMAN	PCI domain containing 2	85					negative regulation of apoptosis|negative regulation of cysteine-type endopeptidase activity|positive regulation of mitotic cell cycle spindle assembly checkpoint|positive regulation of transcription, DNA-dependent|regulation of mRNA stability|spleen development		protein binding				0	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_lung(25;0.216)|all_epithelial(44;0.234)	all cancers(43;0.104)															---	---	---	---
FAM70B	348013	broad.mit.edu	37	13	114507949	114507949	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:114507949G>A	uc001vuh.2	+	8	788	c.761G>A	c.(760-762)CGC>CAC	p.R254H		NM_182614	NP_872420	Q8WV15	FA70B_HUMAN	family with sequence similarity 70, member B	254						integral to membrane					0	Lung NSC(43;0.00976)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_lung(25;0.123)|all_epithelial(44;0.133)	all cancers(43;0.181)															---	---	---	---
RNASE9	390443	broad.mit.edu	37	14	21025060	21025060	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:21025060C>T	uc010aho.2	-	4	328	c.169G>A	c.(169-171)GCC>ACC	p.A57T	RNASE9_uc001vxq.3_Missense_Mutation_p.A62T|RNASE9_uc010ahp.2_Missense_Mutation_p.A62T|RNASE9_uc010ahq.2_Missense_Mutation_p.A62T|RNASE9_uc010ahr.2_Missense_Mutation_p.A62T|RNASE9_uc010ahs.2_Missense_Mutation_p.A57T|RNASE9_uc010aht.2_Missense_Mutation_p.A57T|RNASE9_uc010ahu.2_Missense_Mutation_p.A57T	NM_001110357	NP_001103827	P60153	RNAS9_HUMAN	ribonuclease, RNase A family, 9 (non-active)	57						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			ovary(2)	2	all_cancers(95;0.00238)		Epithelial(56;3.32e-06)|all cancers(55;2.46e-05)	GBM - Glioblastoma multiforme(265;0.0141)														---	---	---	---
RNASE2	6036	broad.mit.edu	37	14	21423932	21423932	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:21423932T>C	uc010aif.2	+	2	71	c.2T>C	c.(1-3)ATG>ACG	p.M1T	RNASE2_uc001vyl.1_Missense_Mutation_p.M1T	NM_002934	NP_002925	P10153	RNAS2_HUMAN	ribonuclease, RNase A family, 2 (liver,	1					chemotaxis|RNA catabolic process	extracellular region|lysosome	nucleic acid binding|pancreatic ribonuclease activity			ovary(1)	1	all_cancers(95;0.00381)		OV - Ovarian serous cystadenocarcinoma(11;6.3e-09)|Epithelial(56;1.42e-07)|all cancers(55;5.48e-07)	GBM - Glioblastoma multiforme(265;0.0187)														---	---	---	---
Unknown	0	broad.mit.edu	37	14	22952006	22952006	+	Intron	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:22952006T>C	uc001wbw.2	+						uc010aja.1_RNA|uc010tmk.1_Intron|uc010tmo.1_Intron|uc001wco.2_RNA|uc010aje.1_Intron|uc001wcp.2_Silent_p.G116G|uc001wcr.1_Intron|uc001wcs.1_Intron|uc010ajf.1_Intron|uc001wcx.3_Intron|uc001wdd.2_Silent_p.G113G|uc010ajj.1_Intron|uc001wde.1_Intron|uc001wdf.2_Intron|uc010ajk.1_Silent_p.G113G|uc001wdg.1_Intron|uc010ajl.1_Intron|uc001wdj.2_Intron|uc010ajo.1_Intron|uc010ajp.1_Intron|uc001wds.1_5'Flank|uc001wdv.3_Intron|uc001wec.2_Intron|uc001wee.3_Intron|uc010tmt.1_Intron|uc010ajv.1_Intron|uc001weg.2_Intron|uc001weh.1_RNA					SubName: Full=Alpha-chain C region; Flags: Fragment;																														---	---	---	---
CDH24	64403	broad.mit.edu	37	14	23518309	23518309	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:23518309C>A	uc001wil.2	-	12	2147	c.1887G>T	c.(1885-1887)GAG>GAT	p.E629D	CDH24_uc001wik.3_RNA|CDH24_uc010akf.2_Missense_Mutation_p.E591D	NM_022478	NP_071923	Q86UP0	CAD24_HUMAN	cadherin-like 24 isoform 1	629	Cadherin 5.|Extracellular (Potential).				adherens junction organization|cell junction assembly|cell-cell adhesion|homophilic cell adhesion	cell-cell junction|cell-cell junction|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|delta-catenin binding			central_nervous_system(1)	1	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00654)														---	---	---	---
RNF31	55072	broad.mit.edu	37	14	24619849	24619849	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:24619849T>C	uc001wmn.1	+	8	1489	c.1240T>C	c.(1240-1242)TAC>CAC	p.Y414H	RNF31_uc001wml.1_Missense_Mutation_p.Y263H|RNF31_uc001wmm.1_Intron|RNF31_uc010alg.1_Missense_Mutation_p.Y229H|RNF31_uc001wmo.1_5'Flank|RNF31_uc001wmp.2_5'Flank	NM_017999	NP_060469	Q96EP0	RNF31_HUMAN	ring finger protein 31	414	Polyubiquitin-binding.|RanBP2-type 3.				CD40 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein linear polyubiquitination|T cell receptor signaling pathway	CD40 receptor complex|internal side of plasma membrane|LUBAC complex	ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00861)														---	---	---	---
ARHGAP5	394	broad.mit.edu	37	14	32562773	32562773	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:32562773A>G	uc001wrl.2	+	2	3137	c.2898A>G	c.(2896-2898)CTA>CTG	p.L966L	ARHGAP5_uc001wrm.2_Silent_p.L966L|ARHGAP5_uc001wrn.2_Silent_p.L966L|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	966					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)														---	---	---	---
SNX6	58533	broad.mit.edu	37	14	35045035	35045035	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:35045035C>T	uc001wsf.1	-	11	892	c.884G>A	c.(883-885)CGA>CAA	p.R295Q	SNX6_uc001wse.1_Missense_Mutation_p.R167Q|SNX6_uc010tpm.1_Missense_Mutation_p.R171Q|SNX6_uc010amm.1_Missense_Mutation_p.R171Q	NM_152233	NP_689419	Q9UNH7	SNX6_HUMAN	sorting nexin 6 isoform b	283					cell communication|intracellular protein transport|negative regulation of epidermal growth factor receptor activity|negative regulation of transcription, DNA-dependent|negative regulation of transforming growth factor beta receptor signaling pathway|retrograde transport, endosome to Golgi	cytoplasmic vesicle membrane|early endosome membrane|nucleus	phosphatidylinositol binding|protein homodimerization activity				0	Breast(36;0.0473)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00199)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.0245)														---	---	---	---
BAZ1A	11177	broad.mit.edu	37	14	35227976	35227976	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:35227976T>C	uc001wsk.2	-	25	4888	c.4320A>G	c.(4318-4320)CAA>CAG	p.Q1440Q	BAZ1A_uc001wsl.2_Silent_p.Q1408Q	NM_013448	NP_038476	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	1440					chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			lung(2)|central_nervous_system(2)|ovary(1)|breast(1)|skin(1)	7	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)														---	---	---	---
INSM2	84684	broad.mit.edu	37	14	36004558	36004558	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:36004558C>A	uc001wth.1	+	1	1311	c.1100C>A	c.(1099-1101)CCG>CAG	p.P367Q		NM_032594	NP_115983	Q96T92	INSM2_HUMAN	insulinoma-associated protein IA-6	367					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			lung(1)|skin(1)	2	Breast(36;0.122)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(9;2.16e-07)|Lung(238;2.63e-07)|Epithelial(34;0.00145)|all cancers(34;0.00452)	GBM - Glioblastoma multiforme(112;0.0223)														---	---	---	---
PAX9	5083	broad.mit.edu	37	14	37132606	37132606	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:37132606C>T	uc001wty.3	+	3	1226	c.509C>T	c.(508-510)GCC>GTC	p.A170V	PAX9_uc010amq.2_5'Flank	NM_006194	NP_006185	P55771	PAX9_HUMAN	paired box 9	170	Interaction with KDM5B.				multicellular organismal development|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)|Breast(36;0.218)		Lung(8;1.12e-09)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.00357)|all cancers(34;0.00998)|LUSC - Lung squamous cell carcinoma(13;0.0189)	GBM - Glioblastoma multiforme(112;0.0181)														---	---	---	---
MIPOL1	145282	broad.mit.edu	37	14	37754595	37754595	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:37754595T>C	uc001wuc.2	+	8	1069	c.566T>C	c.(565-567)ATT>ACT	p.I189T	MIPOL1_uc010amr.2_Intron|MIPOL1_uc001wub.3_Missense_Mutation_p.I158T|MIPOL1_uc001wud.2_Missense_Mutation_p.I189T|MIPOL1_uc010ams.2_Missense_Mutation_p.I189T|MIPOL1_uc001wue.2_Missense_Mutation_p.I158T|MIPOL1_uc010amt.2_Missense_Mutation_p.I8T	NM_138731	NP_620059	Q8TD10	MIPO1_HUMAN	mirror-image polydactyly 1	189	Potential.									ovary(1)|central_nervous_system(1)	2	Breast(36;0.119)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;6.03e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.047)|all cancers(34;0.0953)|LUSC - Lung squamous cell carcinoma(13;0.0975)|BRCA - Breast invasive adenocarcinoma(188;0.196)	GBM - Glioblastoma multiforme(112;0.0358)														---	---	---	---
Unknown	0	broad.mit.edu	37	14	38286771	38286771	+	Intron	SNP	A	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:38286771A>C	uc001wug.2	+						uc001wuh.2_Intron|uc001wui.2_Intron|uc001wuj.2_Intron					Homo sapiens chromosome 14 open reading frame 25, mRNA (cDNA clone IMAGE:5268731), partial cds.																														---	---	---	---
FANCM	57697	broad.mit.edu	37	14	45665536	45665536	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:45665536T>C	uc001wwd.3	+	21	5601	c.5502T>C	c.(5500-5502)ATT>ATC	p.I1834I	FANCM_uc010anf.2_Silent_p.I1808I|FANCM_uc001wwe.3_Silent_p.I1370I|FANCM_uc010ang.2_Silent_p.I1083I	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	1834	Interaction with FAAP24 and EME1.				DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7													Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				---	---	---	---
POLE2	5427	broad.mit.edu	37	14	50131378	50131378	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:50131378A>G	uc001wwu.2	-	9	662	c.648T>C	c.(646-648)GGT>GGC	p.G216G	SDCCAG1_uc010anj.1_Intron|POLE2_uc010ann.2_5'UTR|POLE2_uc001wwv.2_RNA|POLE2_uc010ano.2_5'UTR	NM_002692	NP_002683	P56282	DPOE2_HUMAN	DNA-directed DNA polymerase epsilon 2	216					DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA binding|DNA-directed DNA polymerase activity			ovary(1)|skin(1)	2	all_epithelial(31;0.0021)|Breast(41;0.0124)																	---	---	---	---
NIN	51199	broad.mit.edu	37	14	51230591	51230591	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:51230591G>T	uc001wym.2	-	15	1918	c.1727C>A	c.(1726-1728)CCG>CAG	p.P576Q	NIN_uc001wyi.2_Missense_Mutation_p.P576Q|NIN_uc001wyj.2_RNA|NIN_uc001wyk.2_Missense_Mutation_p.P576Q|NIN_uc010tqp.1_Missense_Mutation_p.P582Q|NIN_uc001wyo.2_Missense_Mutation_p.P576Q	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	576					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)							T	PDGFRB	MPD								---	---	---	---
DLGAP5	9787	broad.mit.edu	37	14	55650367	55650367	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:55650367G>A	uc001xbs.2	-	3	560	c.343C>T	c.(343-345)CGA>TGA	p.R115*	DLGAP5_uc001xbt.2_Nonsense_Mutation_p.R115*	NM_014750	NP_055565	Q15398	DLGP5_HUMAN	discs large homolog 7 isoform a	115	Potential.				cell proliferation|cell-cell signaling|mitotic chromosome movement towards spindle pole|positive regulation of mitotic metaphase/anaphase transition	nucleus|spindle pole centrosome	phosphoprotein phosphatase activity|protein binding			ovary(1)|skin(1)	2																		---	---	---	---
C14orf101	54916	broad.mit.edu	37	14	57052589	57052589	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:57052589T>C	uc001xcm.2	+	3	425	c.303T>C	c.(301-303)TTT>TTC	p.F101F	C14orf101_uc001xcj.2_RNA|C14orf101_uc001xck.2_Silent_p.F101F|C14orf101_uc010aot.1_Silent_p.F101F|C14orf101_uc001xcl.1_RNA|C14orf101_uc001xcn.2_RNA|C14orf101_uc010trf.1_5'UTR	NM_017799	NP_060269	Q9NX78	CN101_HUMAN	hypothetical protein LOC54916	101	Helical; (Potential).					integral to membrane				breast(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(311;0.226)														---	---	---	---
ACTR10	55860	broad.mit.edu	37	14	58669640	58669640	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:58669640C>T	uc001xdf.2	+	2	248	c.145C>T	c.(145-147)CCT>TCT	p.P49S	C14orf37_uc010tro.1_Intron|ACTR10_uc001xdg.2_5'UTR|ACTR10_uc001xdh.2_5'UTR	NM_018477	NP_060947	Q9NZ32	ARP10_HUMAN	uncharacterized hypothalamus protein HARP11	49						cytoplasm				central_nervous_system(1)	1																		---	---	---	---
TRMT5	57570	broad.mit.edu	37	14	61446155	61446155	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:61446155G>A	uc001xff.3	-	2	552	c.461C>T	c.(460-462)GCA>GTA	p.A154V	SLC38A6_uc001xfg.1_5'Flank|SLC38A6_uc001xfh.1_5'Flank|SLC38A6_uc001xfi.2_5'Flank|SLC38A6_uc001xfj.1_5'Flank|SLC38A6_uc001xfk.2_5'Flank|SLC38A6_uc010trz.1_5'Flank	NM_020810	NP_065861	Q32P41	TRMT5_HUMAN	tRNA methyltransferase 5	154						cytoplasm	tRNA (guanine-N1-)-methyltransferase activity			central_nervous_system(2)|large_intestine(1)	3				OV - Ovarian serous cystadenocarcinoma(108;0.0873)														---	---	---	---
TRMT5	57570	broad.mit.edu	37	14	61446156	61446156	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:61446156C>T	uc001xff.3	-	2	551	c.460G>A	c.(460-462)GCA>ACA	p.A154T	SLC38A6_uc001xfg.1_5'Flank|SLC38A6_uc001xfh.1_5'Flank|SLC38A6_uc001xfi.2_5'Flank|SLC38A6_uc001xfj.1_5'Flank|SLC38A6_uc001xfk.2_5'Flank|SLC38A6_uc010trz.1_5'Flank	NM_020810	NP_065861	Q32P41	TRMT5_HUMAN	tRNA methyltransferase 5	154						cytoplasm	tRNA (guanine-N1-)-methyltransferase activity			central_nervous_system(2)|large_intestine(1)	3				OV - Ovarian serous cystadenocarcinoma(108;0.0873)														---	---	---	---
TRMT5	57570	broad.mit.edu	37	14	61446523	61446523	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:61446523A>G	uc001xff.3	-	2	184	c.93T>C	c.(91-93)ATT>ATC	p.I31I	SLC38A6_uc001xfg.1_5'Flank|SLC38A6_uc001xfh.1_5'Flank|SLC38A6_uc001xfi.2_5'Flank|SLC38A6_uc001xfj.1_5'Flank|SLC38A6_uc001xfk.2_5'Flank|SLC38A6_uc010trz.1_5'Flank	NM_020810	NP_065861	Q32P41	TRMT5_HUMAN	tRNA methyltransferase 5	31						cytoplasm	tRNA (guanine-N1-)-methyltransferase activity			central_nervous_system(2)|large_intestine(1)	3				OV - Ovarian serous cystadenocarcinoma(108;0.0873)														---	---	---	---
ZBTB1	22890	broad.mit.edu	37	14	64988914	64988914	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:64988914T>C	uc001xhh.3	+	4	1123	c.692T>C	c.(691-693)TTA>TCA	p.L231S	ZBTB1_uc010aqg.2_Missense_Mutation_p.L231S|ZBTB1_uc001xhi.2_Missense_Mutation_p.L231S	NM_001123329	NP_001116801	Q9Y2K1	ZBTB1_HUMAN	zinc finger and BTB domain containing 1 isoform	231	C2H2-type 1; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		all_lung(585;0.000567)|Myeloproliferative disorder(585;0.0255)|all_neural(303;0.0294)		UCEC - Uterine corpus endometrioid carcinoma (185;0.0182)|all cancers(60;3.78e-43)|OV - Ovarian serous cystadenocarcinoma(108;1.22e-20)|BRCA - Breast invasive adenocarcinoma(234;6.75e-06)|KIRC - Kidney renal clear cell carcinoma(182;0.00269)|STAD - Stomach adenocarcinoma(64;0.012)														---	---	---	---
HSPA2	3306	broad.mit.edu	37	14	65008542	65008542	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:65008542C>T	uc001xhj.2	+	2	1051	c.975C>T	c.(973-975)CGC>CGT	p.R325R	HSPA2_uc001xhk.3_Silent_p.R325R	NM_021979	NP_068814	P54652	HSP72_HUMAN	heat shock 70kDa protein 2	325					response to unfolded protein|spermatid development	cell surface	ATP binding|unfolded protein binding			skin(1)	1				all cancers(60;0.00515)|OV - Ovarian serous cystadenocarcinoma(108;0.00584)|BRCA - Breast invasive adenocarcinoma(234;0.045)														---	---	---	---
C14orf50	145376	broad.mit.edu	37	14	65019585	65019585	+	Intron	SNP	T	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:65019585T>A	uc001xhl.1	+							NM_172365	NP_758953			hypothetical protein LOC145376											skin(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.00382)|all cancers(60;0.00427)|BRCA - Breast invasive adenocarcinoma(234;0.0488)														---	---	---	---
GPHN	10243	broad.mit.edu	37	14	66975274	66975274	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:66975274A>G	uc001xiy.2	+	1	1150	c.29A>G	c.(28-30)AAC>AGC	p.N10S	GPHN_uc001xiw.2_Missense_Mutation_p.N10S|GPHN_uc001xix.2_Missense_Mutation_p.N10S|GPHN_uc010tss.1_Missense_Mutation_p.N10S|GPHN_uc010tst.1_Missense_Mutation_p.N10S|uc010tsr.1_5'Flank	NM_001024218	NP_001019389	Q9NQX3	GEPH_HUMAN	gephyrin isoform 2	10			N -> Y (in STHE; sporadic case).		Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cell junction|cytoplasm|cytoskeleton|postsynaptic membrane	ATP binding|metal ion binding|nucleotidyltransferase activity			ovary(2)	2		all_cancers(7;0.0476)|all_hematologic(31;0.0116)		Epithelial(1;1.73e-08)|all cancers(60;3.15e-07)|OV - Ovarian serous cystadenocarcinoma(108;0.000275)|BRCA - Breast invasive adenocarcinoma(234;0.00323)|Colorectal(3;0.0938)|KIRC - Kidney renal clear cell carcinoma(182;0.184)				T	MLL	AL								---	---	---	---
PNMA1	9240	broad.mit.edu	37	14	74179954	74179954	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:74179954G>A	uc001xor.1	-	1	1175	c.389C>T	c.(388-390)CCG>CTG	p.P130L		NM_006029	NP_006020	Q8ND90	PNMA1_HUMAN	paraneoplastic antigen MA1	130					apoptosis|central nervous system development|inflammatory response to antigenic stimulus|spermatogenesis	cytoplasm|focal adhesion|nucleolus	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00331)|KIRC - Kidney renal clear cell carcinoma(182;0.0797)														---	---	---	---
DLST	1743	broad.mit.edu	37	14	75361033	75361033	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:75361033C>T	uc001xqv.2	+	10	754	c.691C>T	c.(691-693)CGG>TGG	p.R231W	DLST_uc001xqu.2_Missense_Mutation_p.R143W|DLST_uc001xqt.2_Missense_Mutation_p.R147W|DLST_uc010tuw.1_Missense_Mutation_p.R145W|DLST_uc001xqs.2_RNA|DLST_uc010tuv.1_Missense_Mutation_p.R231W	NM_001933	NP_001924	P36957	ODO2_HUMAN	dihydrolipoamide S-succinyltransferase (E2	231					lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	dihydrolipoyllysine-residue succinyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00698)														---	---	---	---
FAM164C	79696	broad.mit.edu	37	14	75537864	75537864	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:75537864G>A	uc001xri.2	+	2	761	c.588G>A	c.(586-588)ACG>ACA	p.T196T	FAM164C_uc001xrh.2_Silent_p.T196T	NM_001042430	NP_001035895	Q53FD0	F164C_HUMAN	chromosome 14 open reading frame 140 isoform b	196										ovary(1)	1																		---	---	---	---
BATF	10538	broad.mit.edu	37	14	75991481	75991481	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:75991481G>A	uc001xrr.2	+	2	360	c.118G>A	c.(118-120)GCC>ACC	p.A40T		NM_006399	NP_006390	Q16520	BATF_HUMAN	basic leucine zipper transcription factor,	40	Basic motif.					nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.028)														---	---	---	---
TTLL5	23093	broad.mit.edu	37	14	76368497	76368497	+	Silent	SNP	G	A	A	rs142835737	byFrequency	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:76368497G>A	uc001xrx.2	+	31	3958	c.3753G>A	c.(3751-3753)GCG>GCA	p.A1251A	TTLL5_uc001xsa.2_Silent_p.A325A	NM_015072	NP_055887	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	1251					protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.029)														---	---	---	---
C14orf179	112752	broad.mit.edu	37	14	76549611	76549611	+	Silent	SNP	G	A	A	rs143729954		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:76549611G>A	uc010asm.1	+	8	520	c.486G>A	c.(484-486)GCG>GCA	p.A162A	C14orf179_uc001xsg.2_Silent_p.A167A|C14orf179_uc010tve.1_RNA	NM_001102564	NP_001096034	Q96FT9	IFT43_HUMAN	hypothetical protein LOC112752 isoform 2	162					cilium morphogenesis|intraflagellar retrograde transport						0				BRCA - Breast invasive adenocarcinoma(234;0.0199)														---	---	---	---
C14orf4	64207	broad.mit.edu	37	14	77493111	77493111	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:77493111C>T	uc001xsy.2	-	1	1924	c.1025G>A	c.(1024-1026)CGC>CAC	p.R342H		NM_024496	NP_078772	Q9H1B7	I2BPL_HUMAN	chromosome 14 open reading frame 4	342	Potential.					nucleus					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.00347)|KIRC - Kidney renal clear cell carcinoma(182;0.0878)														---	---	---	---
NRXN3	9369	broad.mit.edu	37	14	79181267	79181267	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:79181267G>A	uc001xun.2	+	5	1201	c.710G>A	c.(709-711)TGC>TAC	p.C237Y	NRXN3_uc001xum.1_RNA|NRXN3_uc010asv.1_Missense_Mutation_p.C371Y	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	610	Extracellular (Potential).|Laminin G-like 3.				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)														---	---	---	---
TSHR	7253	broad.mit.edu	37	14	81422185	81422185	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:81422185C>T	uc001xvd.1	+	1	317	c.161C>T	c.(160-162)ACG>ATG	p.T54M	C14orf145_uc001xva.1_Intron|TSHR_uc001xvb.1_Missense_Mutation_p.T54M|TSHR_uc001xvc.2_Missense_Mutation_p.T54M|TSHR_uc010tvs.1_Missense_Mutation_p.T54M	NM_000369	NP_000360	P16473	TSHR_HUMAN	thyroid stimulating hormone receptor isoform 1	54	Extracellular (Potential).				cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			thyroid(289)|ovary(5)|lung(3)|kidney(1)|skin(1)	299				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)			Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism 						---	---	---	---
TSHR	7253	broad.mit.edu	37	14	81610680	81610680	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:81610680A>G	uc001xvd.1	+	10	2434	c.2278A>G	c.(2278-2280)ATG>GTG	p.M760V		NM_000369	NP_000360	P16473	TSHR_HUMAN	thyroid stimulating hormone receptor isoform 1	760	Cytoplasmic (Potential).				cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			thyroid(289)|ovary(5)|lung(3)|kidney(1)|skin(1)	299				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)			Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism 						---	---	---	---
GTF2A1	2957	broad.mit.edu	37	14	81670341	81670341	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:81670341C>A	uc001xvf.1	-	3	672	c.240G>T	c.(238-240)CAG>CAT	p.Q80H	GTF2A1_uc010atb.1_Missense_Mutation_p.Q30H|GTF2A1_uc001xvg.1_Missense_Mutation_p.Q41H|GTF2A1_uc001xvh.1_Missense_Mutation_p.Q41H|SNORA79_uc001xvi.1_5'Flank	NM_015859	NP_056943	P52655	TF2AA_HUMAN	TFIIA alpha, p55 isoform 1	80	Poly-Gln.				regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|transcription factor TFIIA complex	DNA binding|protein binding|protein heterodimerization activity|TBP-class protein binding|transcription coactivator activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0287)														---	---	---	---
STON2	85439	broad.mit.edu	37	14	81743536	81743536	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:81743536G>A	uc010tvu.1	-	4	2320	c.2119C>T	c.(2119-2121)CTG>TTG	p.L707L	STON2_uc001xvk.1_Silent_p.L707L|STON2_uc010tvt.1_Silent_p.L504L	NM_033104	NP_149095	Q8WXE9	STON2_HUMAN	stonin 2	707	MHD.				endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			skin(3)|pancreas(2)	5				BRCA - Breast invasive adenocarcinoma(234;0.0348)														---	---	---	---
STON2	85439	broad.mit.edu	37	14	81837500	81837500	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:81837500A>G	uc010tvu.1	-	3	604	c.403T>C	c.(403-405)TGC>CGC	p.C135R	STON2_uc001xvk.1_Missense_Mutation_p.C135R	NM_033104	NP_149095	Q8WXE9	STON2_HUMAN	stonin 2	135					endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			skin(3)|pancreas(2)	5				BRCA - Breast invasive adenocarcinoma(234;0.0348)														---	---	---	---
CCDC88C	440193	broad.mit.edu	37	14	91770131	91770131	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:91770131G>A	uc010aty.2	-	20	3648	c.3549C>T	c.(3547-3549)GCC>GCT	p.A1183A		NM_001080414	NP_001073883	Q9P219	DAPLE_HUMAN	DVL-binding protein DAPLE	1183	Potential.				microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			ovary(3)	3		all_cancers(154;0.0468)																---	---	---	---
CPSF2	53981	broad.mit.edu	37	14	92597333	92597333	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:92597333C>T	uc001yah.1	+	3	242	c.5C>T	c.(4-6)ACG>ATG	p.T2M		NM_017437	NP_059133	Q9P2I0	CPSF2_HUMAN	cleavage and polyadenylation specific factor 2	2					histone mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	hydrolase activity|protein binding|RNA binding			ovary(2)	2		all_cancers(154;0.0766)		COAD - Colon adenocarcinoma(157;0.222)														---	---	---	---
SLC24A4	123041	broad.mit.edu	37	14	92959973	92959973	+	3'UTR	SNP	C	T	T	rs151142678	byFrequency	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:92959973C>T	uc001yak.2	+	17					SLC24A4_uc001yai.2_3'UTR|SLC24A4_uc010twm.1_3'UTR|SLC24A4_uc001yaj.2_3'UTR|SLC24A4_uc010auj.2_3'UTR|SLC24A4_uc010twn.1_3'UTR|SLC24A4_uc001yan.2_3'UTR	NM_153646	NP_705932			solute carrier family 24 member 4 isoform 1							integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(2)|ovary(1)	3		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)														---	---	---	---
C14orf109	26175	broad.mit.edu	37	14	93652935	93652935	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:93652935C>T	uc010auo.2	+	2	787	c.429C>T	c.(427-429)TGC>TGT	p.C143C	MOAP1_uc001ybj.2_5'Flank|C14orf109_uc001ybk.3_Silent_p.C105C	NM_001098621	NP_001092091	Q8N6I4	CN109_HUMAN	hypothetical protein LOC26175 isoform 1	137						integral to membrane					0		all_cancers(154;0.11)|Acute lymphoblastic leukemia(33;0.0488)		Epithelial(152;0.176)|all cancers(159;0.197)|COAD - Colon adenocarcinoma(157;0.202)														---	---	---	---
GSC	145258	broad.mit.edu	37	14	95235311	95235311	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:95235311C>T	uc001ydu.2	-	2	746	c.599G>A	c.(598-600)CGC>CAC	p.R200H		NM_173849	NP_776248	P56915	GSC_HUMAN	goosecoid	200	Homeobox.				gastrulation|middle ear morphogenesis		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(154;0.0896)|all_epithelial(191;0.219)		COAD - Colon adenocarcinoma(157;0.202)|Epithelial(152;0.239)														---	---	---	---
DICER1	23405	broad.mit.edu	37	14	95590985	95590985	+	Silent	SNP	G	A	A	rs142397473	byFrequency;by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:95590985G>A	uc001ydw.2	-	9	1106	c.924C>T	c.(922-924)GCC>GCT	p.A308A	DICER1_uc001ydv.2_Silent_p.A298A|DICER1_uc001ydx.2_Silent_p.A308A	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	308	Required for interaction with PRKRA and TARBP2.				negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)				Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				---	---	---	---
ATG2B	55102	broad.mit.edu	37	14	96797967	96797967	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:96797967T>C	uc001yfi.2	-	11	1841	c.1476A>G	c.(1474-1476)CCA>CCG	p.P492P		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	492										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)														---	---	---	---
BEGAIN	57596	broad.mit.edu	37	14	101005631	101005631	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:101005631G>A	uc010txa.1	-	6	603	c.457C>T	c.(457-459)CGC>TGC	p.R153C	BEGAIN_uc001yhp.2_Missense_Mutation_p.R89C|BEGAIN_uc001yhq.2_Missense_Mutation_p.R153C	NM_001159531	NP_001153003	Q9BUH8	BEGIN_HUMAN	brain-enriched guanylate kinase-associated	153						cytoplasm|membrane	protein binding				0		Melanoma(154;0.212)																---	---	---	---
RTL1	388015	broad.mit.edu	37	14	101347381	101347381	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:101347381G>A	uc010txj.1	-	1	3804	c.3745C>T	c.(3745-3747)CAT>TAT	p.H1249Y	MIR431_hsa-mir-431|MI0001721_RNA|MIR433_hsa-mir-433|MI0001723_5'Flank|uc001yig.3_5'Flank|MIR127_hsa-mir-127|MI0000472_5'Flank	NM_001134888	NP_001128360	A6NKG5	RTL1_HUMAN	retrotransposon-like 1	1249										pancreas(1)	1																		---	---	---	---
RTL1	388015	broad.mit.edu	37	14	101348236	101348236	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:101348236C>T	uc010txj.1	-	1	2949	c.2890G>A	c.(2890-2892)GTA>ATA	p.V964I	MIR433_hsa-mir-433|MI0001723_RNA|uc001yig.3_5'Flank|MIR127_hsa-mir-127|MI0000472_5'Flank|MIR432_hsa-mir-432|MI0003133_5'Flank|uc010txk.1_5'Flank|MIR136_hsa-mir-136|MI0000475_5'Flank	NM_001134888	NP_001128360	A6NKG5	RTL1_HUMAN	retrotransposon-like 1	964										pancreas(1)	1																		---	---	---	---
DIO3OS	64150	broad.mit.edu	37	14	102026620	102026620	+	5'UTR	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:102026620G>A	uc001ykd.1	-	1					uc001yke.2_5'UTR|uc001ykf.2_5'UTR|uc001ykg.2_5'UTR|uc001ykh.3_RNA|DIO3_uc010txq.1_5'Flank					Homo sapiens uterine-derived 14 kDa protein mRNA, complete cds.												0																		---	---	---	---
MARK3	4140	broad.mit.edu	37	14	103941357	103941357	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:103941357C>T	uc001ymz.3	+	13	1958	c.1292C>T	c.(1291-1293)GCG>GTG	p.A431V	MARK3_uc001ymx.3_Missense_Mutation_p.A431V|MARK3_uc001ymw.3_Missense_Mutation_p.A431V|MARK3_uc001yna.3_Missense_Mutation_p.A415V|MARK3_uc001ymy.3_Missense_Mutation_p.A352V|MARK3_uc010awp.2_Missense_Mutation_p.A454V|MARK3_uc010tyb.1_Missense_Mutation_p.A226V|MARK3_uc010awq.2_5'UTR	NM_001128918	NP_001122390	P27448	MARK3_HUMAN	MAP/microtubule affinity-regulating kinase 3	431							ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)|ovary(1)|stomach(1)	4		Melanoma(154;0.155)	Epithelial(46;0.241)															---	---	---	---
MARK3	4140	broad.mit.edu	37	14	103941521	103941521	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:103941521C>T	uc001ymz.3	+	13	2122	c.1456C>T	c.(1456-1458)CGC>TGC	p.R486C	MARK3_uc001ymx.3_Missense_Mutation_p.R486C|MARK3_uc001ymw.3_Missense_Mutation_p.R486C|MARK3_uc001yna.3_Missense_Mutation_p.R470C|MARK3_uc001ymy.3_Missense_Mutation_p.R407C|MARK3_uc010awp.2_Missense_Mutation_p.R509C|MARK3_uc010tyb.1_Missense_Mutation_p.R281C|MARK3_uc010awq.2_Missense_Mutation_p.R16C	NM_001128918	NP_001122390	P27448	MARK3_HUMAN	MAP/microtubule affinity-regulating kinase 3	486							ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)|ovary(1)|stomach(1)	4		Melanoma(154;0.155)	Epithelial(46;0.241)															---	---	---	---
KIF26A	26153	broad.mit.edu	37	14	104639382	104639382	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:104639382T>C	uc001yos.3	+	8	1489	c.1489T>C	c.(1489-1491)TCC>CCC	p.S497P		NM_015656	NP_056471	Q9ULI4	KI26A_HUMAN	kinesin family member 26A	497	Kinesin-motor.				blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			pancreas(1)	1		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)														---	---	---	---
ADSSL1	122622	broad.mit.edu	37	14	105206963	105206963	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:105206963G>A	uc001ypd.2	+	6	576	c.502G>A	c.(502-504)GGA>AGA	p.G168R	INF2_uc010tyi.1_Intron|ADSSL1_uc001ype.2_Missense_Mutation_p.G211R|ADSSL1_uc001ypf.2_RNA	NM_152328	NP_689541	Q8N142	PURA1_HUMAN	adenylosuccinate synthase like 1 isoform 2	168					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			ovary(1)|central_nervous_system(1)	2		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00153)|OV - Ovarian serous cystadenocarcinoma(23;0.0148)|Epithelial(46;0.0396)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.18)	L-Aspartic Acid(DB00128)													---	---	---	---
KIAA0284	283638	broad.mit.edu	37	14	105353032	105353032	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:105353032G>T	uc010axb.2	+	12	2680	c.2456G>T	c.(2455-2457)GGG>GTG	p.G819V	INF2_uc010tyi.1_Intron|KIAA0284_uc001ypr.2_Missense_Mutation_p.G749V|KIAA0284_uc001yps.2_Missense_Mutation_p.G725V|KIAA0284_uc001ypt.2_5'Flank	NM_001112726	NP_001106197	Q9Y4F5	K0284_HUMAN	hypothetical protein LOC283638 isoform 1	819						cytoplasm|microtubule				breast(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000472)|OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0149)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.178)														---	---	---	---
AHNAK2	113146	broad.mit.edu	37	14	105419601	105419601	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:105419601G>A	uc010axc.1	-	7	2307	c.2187C>T	c.(2185-2187)TCC>TCT	p.S729S	AHNAK2_uc001ypx.2_Silent_p.S629S	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	729						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)															---	---	---	---
ADAM6	8755	broad.mit.edu	37	14	106207924	106207924	+	RNA	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:106207924G>T	uc010tyt.1	-	3628		c.59193C>A			uc001yrs.2_Intron|uc001yrt.2_Intron|uc001yrw.1_Intron|uc001yrx.1_Intron|uc001yrz.1_Intron|uc001yse.2_Silent_p.L159L|uc001ysf.2_Silent_p.L159L					Parts of antibodies, mostly variable regions.												0																		---	---	---	---
ADAM6	8755	broad.mit.edu	37	14	107218732	107218732	+	RNA	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:107218732A>G	uc010tyt.1	-	12		c.982T>C								Parts of antibodies, mostly variable regions.												0																		---	---	---	---
MKRN3	7681	broad.mit.edu	37	15	23811911	23811911	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:23811911C>T	uc001ywh.3	+	1	1458	c.982C>T	c.(982-984)CGC>TGC	p.R328C	MKRN3_uc001ywi.2_Intron|MKRN3_uc010ayi.1_Missense_Mutation_p.R328C	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	328	RING-type.					ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)														---	---	---	---
MAGEL2	54551	broad.mit.edu	37	15	23890382	23890382	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:23890382C>A	uc001ywj.3	-	1	794	c.699G>T	c.(697-699)TGG>TGT	p.W233C		NM_019066	NP_061939			MAGE-like protein 2												0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)														---	---	---	---
SNORD116-4	100033416	broad.mit.edu	37	15	25325356	25325356	+	Intron	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:25325356C>A	uc001yxh.1	+						SNORD116-4_uc001yxm.1_Intron|IPW_uc001yxn.3_Intron|SNORD116-14_uc001yxx.2_RNA|SNORD116-28_uc001yxy.2_5'Flank|SNORD116-15_uc001yxz.2_5'Flank|SNORD116-16_uc001yya.2_5'Flank					Homo sapiens clone kid4 SNURF-SNRPN mRNA, downstream untranslated exons, alternatively spliced.												0																		---	---	---	---
IPW	3653	broad.mit.edu	37	15	25415941	25415941	+	Intron	SNP	C	T	T	rs142013571	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:25415941C>T	uc001yyp.1	+						IPW_uc010aym.1_Intron|SNORD115-1_uc001yyq.1_RNA|SNORD115-2_uc001yyr.1_5'Flank|uc001yys.1_5'Flank					Homo sapiens clone kid12 SNURF-SNRPN mRNA, downstream untranslated exons, alternatively spliced.												0																		---	---	---	---
UBE3A	7337	broad.mit.edu	37	15	25601091	25601091	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:25601091T>C	uc001zaq.2	-	7	2081	c.2081A>G	c.(2080-2082)TAT>TGT	p.Y694C	uc001zae.2_Intron|UBE3A_uc001zar.2_Missense_Mutation_p.Y671C|UBE3A_uc001zas.2_Missense_Mutation_p.Y691C|UBE3A_uc001zat.2_Missense_Mutation_p.Y671C	NM_000462	NP_000453	Q05086	UBE3A_HUMAN	ubiquitin protein ligase E3A isoform 2	694					brain development|interspecies interaction between organisms|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			upper_aerodigestive_tract(1)|ovary(1)|breast(1)	3		all_cancers(20;3.47e-21)|Breast(32;0.00123)		all cancers(64;2.78e-08)|Epithelial(43;8.85e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0155)|Lung(196;0.0616)														---	---	---	---
ATP10A	57194	broad.mit.edu	37	15	25972394	25972394	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:25972394T>C	uc010ayu.2	-	4	866	c.760A>G	c.(760-762)AAG>GAG	p.K254E		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	254	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)														---	---	---	---
HERC2	8924	broad.mit.edu	37	15	28447365	28447365	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:28447365T>A	uc001zbj.2	-	47	7617	c.7511A>T	c.(7510-7512)GAC>GTC	p.D2504V	HERC2_uc001zbk.1_Missense_Mutation_p.D39V	NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	2504					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)														---	---	---	---
HERC2	8924	broad.mit.edu	37	15	28465618	28465618	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:28465618G>A	uc001zbj.2	-	37	5931	c.5825C>T	c.(5824-5826)TCG>TTG	p.S1942L		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	1942					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)														---	---	---	---
HERC2	8924	broad.mit.edu	37	15	28482215	28482215	+	Silent	SNP	A	G	G	rs4035908		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:28482215A>G	uc001zbj.2	-	26	4003	c.3897T>C	c.(3895-3897)TCT>TCC	p.S1299S		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	1299					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)														---	---	---	---
RYR3	6263	broad.mit.edu	37	15	34150026	34150026	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:34150026A>G	uc001zhi.2	+	99	14123	c.14053A>G	c.(14053-14055)ACT>GCT	p.T4685A	RYR3_uc010bar.2_Missense_Mutation_p.T4680A	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	4685	Helical; Name=M8; (Potential).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)														---	---	---	---
ZNF770	54989	broad.mit.edu	37	15	35273809	35273809	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:35273809A>G	uc001ziw.2	-	3	2138	c.1827T>C	c.(1825-1827)CCT>CCC	p.P609P		NM_014106	NP_054825	Q6IQ21	ZN770_HUMAN	zinc finger protein 770	609					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(122;4.59e-10)|all_lung(180;8.78e-09)		all cancers(64;1.97e-18)|GBM - Glioblastoma multiforme(113;2.11e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0643)														---	---	---	---
EIF2AK4	440275	broad.mit.edu	37	15	40301865	40301865	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:40301865A>G	uc001zkm.1	+	26	3677	c.3627A>G	c.(3625-3627)ATA>ATG	p.I1209M	EIF2AK4_uc010bbj.1_Missense_Mutation_p.I910M|EIF2AK4_uc001zkn.1_Missense_Mutation_p.I309M|EIF2AK4_uc001zko.1_Missense_Mutation_p.I147M|EIF2AK4_uc010bbk.1_RNA	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha	1209	Histidyl-tRNA synthetase-like.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			lung(2)|stomach(1)|skin(1)	4		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)														---	---	---	---
C15orf23	90417	broad.mit.edu	37	15	40675480	40675480	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:40675480T>C	uc001zll.2	+	2	376	c.261T>C	c.(259-261)TAT>TAC	p.Y87Y	C15orf23_uc010ucp.1_Silent_p.Y87Y|C15orf23_uc001zlo.2_Silent_p.Y87Y|C15orf23_uc001zlm.2_RNA|C15orf23_uc001zln.2_RNA	NM_033286	NP_150628	Q9Y448	T4AF1_HUMAN	TRAF4 associated factor 1 isoform a	87						nucleus	protein binding			ovary(1)|skin(1)	2		all_cancers(109;2.34e-14)|all_epithelial(112;9.21e-12)|Lung NSC(122;2.95e-09)|all_lung(180;6.03e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3.39e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0798)														---	---	---	---
MAPKBP1	23005	broad.mit.edu	37	15	42109603	42109603	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:42109603C>A	uc001zok.3	+	16	2033	c.1747C>A	c.(1747-1749)CGC>AGC	p.R583S	MAPKBP1_uc001zoj.3_Missense_Mutation_p.R577S|MAPKBP1_uc010bcj.2_Missense_Mutation_p.R84S|MAPKBP1_uc010bci.2_Missense_Mutation_p.R577S|MAPKBP1_uc010udb.1_Missense_Mutation_p.R416S|MAPKBP1_uc010bck.2_5'UTR|MAPKBP1_uc010bcl.2_Missense_Mutation_p.R84S	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	583	WD 9.									central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)														---	---	---	---
GANC	2595	broad.mit.edu	37	15	42632010	42632010	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:42632010A>G	uc001zpi.2	+	17	2301	c.1987A>G	c.(1987-1989)ACC>GCC	p.T663A		NM_198141	NP_937784	Q8TET4	GANC_HUMAN	glucosidase, alpha; neutral C	663					carbohydrate metabolic process		carbohydrate binding|maltose alpha-glucosidase activity			central_nervous_system(2)	2		all_cancers(109;3.08e-16)|all_epithelial(112;7.48e-15)|Lung NSC(122;3.08e-09)|all_lung(180;1.48e-08)|Melanoma(134;0.0574)|Colorectal(260;0.153)		GBM - Glioblastoma multiforme(94;1.06e-06)														---	---	---	---
TTBK2	146057	broad.mit.edu	37	15	43093956	43093956	+	Intron	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:43093956C>T	uc001zqo.2	-						TTBK2_uc010bcy.2_Intron|TTBK2_uc001zqp.2_Intron|TTBK2_uc010bcz.1_Intron	NM_173500	NP_775771			tau tubulin kinase 2						cell death		ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|stomach(1)|pancreas(1)|skin(1)	7		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)														---	---	---	---
DUOXA1	90527	broad.mit.edu	37	15	45410170	45410170	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:45410170C>T	uc001zup.2	-	10	1489	c.1089G>A	c.(1087-1089)TGG>TGA	p.W363*	DUOXA2_uc001zuo.2_3'UTR|DUOXA2_uc010beb.2_RNA|DUOXA1_uc010uem.1_Nonsense_Mutation_p.W318*|DUOXA1_uc010bec.2_Nonsense_Mutation_p.W363*	NM_144565	NP_653166	Q1HG43	DOXA1_HUMAN	Numb-interacting protein	Error:Variant_position_missing_in_Q1HG43_after_alignment					protein transport	endoplasmic reticulum membrane|integral to membrane				ovary(1)	1		all_cancers(109;6.02e-08)|all_epithelial(112;1.83e-06)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.82e-18)|GBM - Glioblastoma multiforme(94;4.39e-07)|COAD - Colon adenocarcinoma(120;0.0676)|Colorectal(133;0.0686)												OREG0023102	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
DUOX1	53905	broad.mit.edu	37	15	45455891	45455891	+	Intron	SNP	T	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:45455891T>A	uc001zus.1	+						DUOX1_uc001zut.1_Intron|DUOX1_uc010bee.1_Intron	NM_017434	NP_059130			dual oxidase 1 precursor						cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			ovary(5)|skin(2)|breast(1)	8		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)												OREG0023103	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
SECISBP2L	9728	broad.mit.edu	37	15	49293144	49293144	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:49293144G>T	uc001zxe.1	-	15	2312	c.2178C>A	c.(2176-2178)ACC>ACA	p.T726T	SECISBP2L_uc001zxd.1_Silent_p.T681T|SECISBP2L_uc010bep.1_Silent_p.T488T	NM_014701	NP_055516	Q93073	SBP2L_HUMAN	SECIS binding protein 2-like	726										breast(1)|skin(1)	2																		---	---	---	---
GLDN	342035	broad.mit.edu	37	15	51693862	51693862	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:51693862A>G	uc002aba.2	+	9	1269	c.1100A>G	c.(1099-1101)TAC>TGC	p.Y367C	GLDN_uc002abb.2_Missense_Mutation_p.Y243C	NM_181789	NP_861454	Q6ZMI3	GLDN_HUMAN	gliomedin	367	Extracellular (Potential).|Olfactomedin-like.				cell differentiation|nervous system development	collagen|integral to membrane|plasma membrane				ovary(2)	2				all cancers(107;0.00194)|GBM - Glioblastoma multiforme(94;0.00942)												OREG0023125	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
MYO5A	4644	broad.mit.edu	37	15	52689455	52689455	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:52689455T>C	uc002aby.2	-	10	1506	c.1262A>G	c.(1261-1263)CAG>CGG	p.Q421R	MYO5A_uc002abx.3_Missense_Mutation_p.Q421R|MYO5A_uc010uge.1_Missense_Mutation_p.Q290R	NM_000259	NP_000250	Q9Y4I1	MYO5A_HUMAN	myosin VA isoform 1	421	Myosin head-like.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|central_nervous_system(1)	4				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)														---	---	---	---
UNC13C	440279	broad.mit.edu	37	15	54630578	54630578	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:54630578C>A	uc002ack.2	+	15	4604	c.4604C>A	c.(4603-4605)CCC>CAC	p.P1535H	UNC13C_uc002acl.2_Missense_Mutation_p.P365H	NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1535					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)														---	---	---	---
NEDD4	4734	broad.mit.edu	37	15	56132872	56132872	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:56132872T>C	uc002adj.2	-	16	3449	c.3149A>G	c.(3148-3150)CAC>CGC	p.H1050R	NEDD4_uc002adl.2_Missense_Mutation_p.H631R|NEDD4_uc002adi.2_Missense_Mutation_p.H978R|NEDD4_uc010ugj.1_Missense_Mutation_p.H1034R|NEDD4_uc010bfm.2_Missense_Mutation_p.H1033R|NEDD4_uc002adk.2_RNA	NM_198400	NP_006145	P46934	NEDD4_HUMAN	neural precursor cell expressed, developmentally	1050	HECT.				development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|RNA polymerase binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|breast(1)	4				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)														---	---	---	---
ALDH1A2	8854	broad.mit.edu	37	15	58357726	58357726	+	Intron	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:58357726G>A	uc002aex.2	-						ALDH1A2_uc002aey.2_Intron|ALDH1A2_uc010ugv.1_Intron|ALDH1A2_uc010ugw.1_Intron	NM_003888	NP_003879			aldehyde dehydrogenase 1A2 isoform 1						negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)													---	---	---	---
ADAM10	102	broad.mit.edu	37	15	58925422	58925422	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:58925422G>A	uc002afd.1	-	9	1593	c.1149C>T	c.(1147-1149)CAC>CAT	p.H383H	ADAM10_uc010bgc.1_RNA|ADAM10_uc010ugz.1_Silent_p.H82H|ADAM10_uc002afe.1_Intron	NM_001110	NP_001101	O14672	ADA10_HUMAN	ADAM metallopeptidase domain 10 precursor	383	Peptidase M12B.|Extracellular (Potential).	Zinc; catalytic.			cell-cell signaling|constitutive protein ectodomain proteolysis|epidermal growth factor receptor signaling pathway|in utero embryonic development|integrin-mediated signaling pathway|monocyte activation|negative regulation of cell adhesion|Notch receptor processing|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of T cell chemotaxis|protein phosphorylation|response to tumor necrosis factor	cell surface|endomembrane system|Golgi-associated vesicle|integral to membrane|nucleus|plasma membrane	integrin binding|metalloendopeptidase activity|protein homodimerization activity|protein kinase binding|SH3 domain binding|zinc ion binding			skin(2)	2				GBM - Glioblastoma multiforme(80;0.202)														---	---	---	---
CCNB2	9133	broad.mit.edu	37	15	59415826	59415826	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:59415826C>A	uc002afz.2	+	8	1234	c.1086C>A	c.(1084-1086)ATC>ATA	p.I362I	CCNB2_uc010bge.2_Silent_p.I234I	NM_004701	NP_004692	O95067	CCNB2_HUMAN	cyclin B2	362					cell cycle checkpoint|cell division|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	centrosome|cytosol|nucleus	protein kinase binding				0																		---	---	---	---
C2CD4B	388125	broad.mit.edu	37	15	62456140	62456140	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:62456140G>A	uc002ahg.2	-	2	1173	c.1044C>T	c.(1042-1044)GGC>GGT	p.G348G		NM_001007595	NP_001007596	A6NLJ0	C2C4B_HUMAN	nuclear localized factor 2	348	C2.					nucleus					0																		---	---	---	---
USP3	9960	broad.mit.edu	37	15	63866611	63866611	+	Intron	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:63866611A>G	uc002amf.2	+						USP3_uc002amg.2_Intron|USP3_uc002amh.2_Intron|USP3_uc010uij.1_Intron|USP3_uc010uik.1_Intron|USP3_uc010bgs.2_Intron|USP3_uc002ami.2_Intron	NM_006537	NP_006528			ubiquitin thiolesterase 3						DNA repair|histone deubiquitination|mitotic cell cycle|regulation of protein stability|ubiquitin-dependent protein catabolic process	nuclear chromatin	histone binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(1)	1				GBM - Glioblastoma multiforme(80;0.0187)														---	---	---	---
PLEKHO2	80301	broad.mit.edu	37	15	65140946	65140946	+	Intron	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:65140946G>T	uc002anv.2	+						PLEKHO2_uc010bgz.2_Intron|PLEKHO2_uc002anw.2_Intron	NM_025201	NP_079477			pleckstrin homology domain containing, family O											ovary(1)|lung(1)	2																		---	---	---	---
DIS3L	115752	broad.mit.edu	37	15	66615118	66615118	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:66615118G>A	uc010ujm.1	+	10	1435	c.1420G>A	c.(1420-1422)GTA>ATA	p.V474I	DIS3L_uc010ujl.1_Missense_Mutation_p.V104I|DIS3L_uc002app.2_Missense_Mutation_p.V391I|DIS3L_uc002apq.2_Missense_Mutation_p.V474I|DIS3L_uc010bho.2_Missense_Mutation_p.V340I	NM_001143688	NP_001137160	Q8TF46	DI3L1_HUMAN	DIS3 mitotic control homolog (S.	474					rRNA catabolic process	cytoplasm|exosome (RNase complex)	exonuclease activity|protein binding|ribonuclease activity|RNA binding			ovary(2)	2																		---	---	---	---
CORO2B	10391	broad.mit.edu	37	15	69011084	69011084	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:69011084C>T	uc002arj.3	+	9	1044	c.1015C>T	c.(1015-1017)CGC>TGC	p.R339C	CORO2B_uc010bic.2_Missense_Mutation_p.R334C|CORO2B_uc002ark.2_Missense_Mutation_p.R106C	NM_006091	NP_006082	Q9UQ03	COR2B_HUMAN	coronin, actin binding protein, 2B	339					actin cytoskeleton organization	actin cytoskeleton|cytoplasm|membrane	actin filament binding			ovary(3)|skin(2)|large_intestine(1)	6																		---	---	---	---
MYO9A	4649	broad.mit.edu	37	15	72172765	72172765	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:72172765A>T	uc002atl.3	-	29	6006	c.5533T>A	c.(5533-5535)TTG>ATG	p.L1845M	MYO9A_uc002atk.2_Missense_Mutation_p.L640M|MYO9A_uc002atm.1_Missense_Mutation_p.L641M	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	1845	Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3																		---	---	---	---
CELF6	60677	broad.mit.edu	37	15	72580753	72580753	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:72580753T>C	uc002auh.2	-	11	1524	c.1214A>G	c.(1213-1215)CAG>CGG	p.Q405R	uc002aug.2_Intron|CELF6_uc002auk.3_RNA|CELF6_uc010biv.1_RNA|CELF6_uc010biw.2_Missense_Mutation_p.Q292R|CELF6_uc010ukl.1_Missense_Mutation_p.Q268R|CELF6_uc010ukm.1_Missense_Mutation_p.Q378R|CELF6_uc002aui.2_Missense_Mutation_p.Q511R|CELF6_uc002auj.2_Missense_Mutation_p.Q292R	NM_052840	NP_443072	Q96J87	CELF6_HUMAN	bruno-like 6, RNA binding protein	405	RRM 3.				mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	nucleotide binding|RNA binding			large_intestine(1)|central_nervous_system(1)|skin(1)	3																		---	---	---	---
C15orf59	388135	broad.mit.edu	37	15	74032759	74032759	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:74032759A>G	uc002avy.2	-	2	726	c.381T>C	c.(379-381)GGT>GGC	p.G127G		NM_001039614	NP_001034703	Q2T9L4	CO059_HUMAN	hypothetical protein LOC388135	127										pancreas(1)	1																		---	---	---	---
CCDC33	80125	broad.mit.edu	37	15	74573063	74573063	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:74573063C>T	uc002axo.2	+	9	1338	c.944C>T	c.(943-945)CCG>CTG	p.P315L	CCDC33_uc002axp.2_Missense_Mutation_p.P137L	NM_025055	NP_079331	Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33 isoform 1	518							protein binding			ovary(3)|skin(2)	5																		---	---	---	---
TMED3	23423	broad.mit.edu	37	15	79606185	79606185	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:79606185C>T	uc002beu.2	+	2	356	c.255C>T	c.(253-255)TAC>TAT	p.Y85Y	TMED3_uc010unj.1_Silent_p.Y85Y|TMED3_uc002bev.2_RNA	NM_007364	NP_031390	Q9Y3Q3	TMED3_HUMAN	transmembrane emp24 domain containing 3	85	Lumenal (Potential).|GOLD.				protein transport	ER-Golgi intermediate compartment membrane|Golgi apparatus|integral to membrane				ovary(1)|skin(1)	2																		---	---	---	---
MEX3B	84206	broad.mit.edu	37	15	82336563	82336563	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:82336563G>A	uc002bgq.1	-	2	963	c.648C>T	c.(646-648)CGC>CGT	p.R216R		NM_032246	NP_115622	Q6ZN04	MEX3B_HUMAN	mex-3 homolog B	216	KH 2.				protein autophosphorylation	cytoplasmic mRNA processing body|nucleus	calcium ion binding|RNA binding|zinc ion binding			breast(1)|kidney(1)	2																		---	---	---	---
AP3B2	8120	broad.mit.edu	37	15	83349406	83349406	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:83349406G>A	uc010uoh.1	-	8	1050	c.873C>T	c.(871-873)CCC>CCT	p.P291P	AP3B2_uc010uoi.1_Silent_p.P291P|AP3B2_uc010uoj.1_Silent_p.P259P|AP3B2_uc010uog.1_5'Flank	NM_004644	NP_004635	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2	291					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			ovary(3)|breast(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.229)															---	---	---	---
ADAMTSL3	57188	broad.mit.edu	37	15	84488696	84488696	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:84488696A>G	uc002bjz.3	+	6	721	c.497A>G	c.(496-498)CAT>CGT	p.H166R	ADAMTSL3_uc002bjy.1_Missense_Mutation_p.H166R|ADAMTSL3_uc010bmt.1_Missense_Mutation_p.H166R|ADAMTSL3_uc010bmu.1_Missense_Mutation_p.H166R	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	166						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)															---	---	---	---
AEN	64782	broad.mit.edu	37	15	89169602	89169602	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:89169602C>T	uc002bmt.2	+	2	313	c.162C>T	c.(160-162)AGC>AGT	p.S54S	AEN_uc010bnl.2_Silent_p.S54S|AEN_uc010bnm.1_Silent_p.S54S	NM_022767	NP_073604	Q8WTP8	AEN_HUMAN	interferon stimulated exonuclease gene	54					apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|response to ionizing radiation	nucleolus|nucleoplasm	exonuclease activity|nucleic acid binding				0																		---	---	---	---
ACAN	176	broad.mit.edu	37	15	89400945	89400945	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:89400945C>A	uc010upo.1	+	12	5503	c.5129C>A	c.(5128-5130)CCT>CAT	p.P1710H	ACAN_uc010upp.1_Missense_Mutation_p.P1710H|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	1710					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)															---	---	---	---
ABHD2	11057	broad.mit.edu	37	15	89719194	89719194	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:89719194C>T	uc002bnj.2	+	11	1607	c.690C>T	c.(688-690)TGC>TGT	p.C230C	ABHD2_uc002bnk.2_Silent_p.C230C	NM_007011	NP_008942	P08910	ABHD2_HUMAN	alpha/beta hydrolase domain containing protein	230						integral to membrane	carboxylesterase activity			ovary(1)|lung(1)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)																	---	---	---	---
C15orf42	90381	broad.mit.edu	37	15	90170282	90170282	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:90170282A>G	uc002boe.2	+	22	5698	c.5698A>G	c.(5698-5700)AAG>GAG	p.K1900E	C15orf42_uc010upv.1_RNA	NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	1900					cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)															---	---	---	---
AP3S2	10239	broad.mit.edu	37	15	90446505	90446505	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:90446505C>T	uc002bos.3	-	5	770	c.615G>A	c.(613-615)TCG>TCA	p.S205S	C15orf38_uc002bot.1_RNA|C15orf38_uc002bou.2_Silent_p.S205S	NM_182616	NP_872422	P59780	AP3S2_HUMAN	hypothetical protein LOC348110	Error:Variant_position_missing_in_P59780_after_alignment					intracellular protein transport|vesicle-mediated transport	cytoplasmic vesicle membrane|Golgi apparatus|membrane coat	protein transporter activity				0	Lung NSC(78;0.0181)|all_lung(78;0.0384)		BRCA - Breast invasive adenocarcinoma(143;0.0107)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.223)															---	---	---	---
TTLL13	440307	broad.mit.edu	37	15	90794020	90794020	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:90794020C>A	uc002bpd.1	+	2	446	c.158C>A	c.(157-159)CCC>CAC	p.P53H	TTLL13_uc002bpe.1_RNA	NM_001029964	NP_001025135	A6NNM8	TTL13_HUMAN	tubulin tyrosine ligase-like family, member 13	53					protein modification process		ATP binding|tubulin-tyrosine ligase activity				0	Melanoma(11;0.00551)|Lung NSC(78;0.0178)|all_lung(78;0.0378)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|BRCA - Breast invasive adenocarcinoma(143;0.0323)|Kidney(142;0.0514)															---	---	---	---
ZNF774	342132	broad.mit.edu	37	15	90903582	90903582	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:90903582C>T	uc002bpk.3	+	4	705	c.519C>T	c.(517-519)CAC>CAT	p.H173H		NM_001004309	NP_001004309	Q6NX45	ZN774_HUMAN	zinc finger protein 774	173	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(11;0.00551)|Lung NSC(78;0.0158)|all_lung(78;0.0331)		BRCA - Breast invasive adenocarcinoma(143;0.0224)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)															---	---	---	---
ADAMTS17	170691	broad.mit.edu	37	15	100739577	100739577	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:100739577G>C	uc002bvv.1	-	8	1206	c.1127C>G	c.(1126-1128)GCC>GGC	p.A376G	ADAMTS17_uc002bvx.1_Missense_Mutation_p.A133G	NM_139057	NP_620688	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1	376	Peptidase M12B.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)														---	---	---	---
ADAMTS17	170691	broad.mit.edu	37	15	100801716	100801716	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:100801716C>T	uc002bvv.1	-	6	1078	c.999G>A	c.(997-999)CCG>CCA	p.P333P	ADAMTS17_uc002bvx.1_Silent_p.P90P	NM_139057	NP_620688	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1	333	Peptidase M12B.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)														---	---	---	---
TARSL2	123283	broad.mit.edu	37	15	102241308	102241308	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:102241308G>A	uc002bxm.2	-	10	1356	c.1301C>T	c.(1300-1302)ACG>ATG	p.T434M	TARSL2_uc002bxl.2_Translation_Start_Site|TARSL2_uc010usi.1_RNA	NM_152334	NP_689547	A2RTX5	SYTC2_HUMAN	threonyl-tRNA synthetase-like 2	434					threonyl-tRNA aminoacylation	cytoplasm	ATP binding|threonine-tRNA ligase activity			ovary(2)	2	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000268)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)															---	---	---	---
TARSL2	123283	broad.mit.edu	37	15	102263369	102263369	+	Splice_Site	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:102263369T>C	uc002bxm.2	-	2	353	c.298_splice	c.e2-1	p.P100_splice	TARSL2_uc010usi.1_Splice_Site	NM_152334	NP_689547			threonyl-tRNA synthetase-like 2						threonyl-tRNA aminoacylation	cytoplasm	ATP binding|threonine-tRNA ligase activity			ovary(2)	2	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000268)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)															---	---	---	---
LUC7L	55692	broad.mit.edu	37	16	277242	277242	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:277242G>A	uc002cgc.1	-	2	266	c.155C>T	c.(154-156)ACG>ATG	p.T52M	LUC7L_uc002cga.1_Missense_Mutation_p.T52M|LUC7L_uc002cgd.1_RNA|LUC7L_uc002cge.1_Missense_Mutation_p.T52M|LUC7L_uc010bqq.1_3'UTR	NM_201412	NP_958815	Q9NQ29	LUC7L_HUMAN	LUC7-like isoform b	52							metal ion binding			central_nervous_system(1)	1		all_cancers(16;1.1e-06)|all_epithelial(16;2.71e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.0138)|all_lung(18;0.0306)																---	---	---	---
RAB40C	57799	broad.mit.edu	37	16	676026	676026	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:676026C>A	uc002chr.2	+	5	586	c.470C>A	c.(469-471)CCC>CAC	p.P157H	RAB40C_uc002chq.2_Missense_Mutation_p.P138H	NM_021168	NP_066991	Q96S21	RB40C_HUMAN	RAB40C, member RAS oncogene family	157					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding				0		Hepatocellular(780;0.0218)																---	---	---	---
CACNA1H	8912	broad.mit.edu	37	16	1261476	1261476	+	Intron	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:1261476G>A	uc002cks.2	+						CACNA1H_uc002ckt.2_Intron|CACNA1H_uc002cku.2_Intron|CACNA1H_uc010brj.2_Intron|CACNA1H_uc002ckv.2_Intron	NM_021098	NP_066921			calcium channel, voltage-dependent, T type,						aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)													---	---	---	---
UBE2I	7329	broad.mit.edu	37	16	1374749	1374749	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:1374749C>T	uc002clc.1	+	7	536	c.432C>T	c.(430-432)TAC>TAT	p.Y144Y	UBE2I_uc002cld.1_Silent_p.Y144Y|UBE2I_uc002clf.1_Silent_p.Y144Y|UBE2I_uc002clg.1_Silent_p.Y144Y	NM_194261	NP_919237	P63279	UBC9_HUMAN	ubiquitin-conjugating enzyme E2I	144					cell division|chromosome segregation|interspecies interaction between organisms|mitosis|negative regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|protein sumoylation	cytoplasm|PML body|synaptonemal complex	ATP binding|enzyme binding|ubiquitin-protein ligase activity			breast(1)|skin(1)	2		Hepatocellular(780;0.00369)																---	---	---	---
MAPK8IP3	23162	broad.mit.edu	37	16	1797263	1797263	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:1797263C>T	uc002cmk.2	+	6	1098	c.978C>T	c.(976-978)CGC>CGT	p.R326R	MAPK8IP3_uc002cmj.1_RNA|MAPK8IP3_uc002cml.2_Silent_p.R326R|MAPK8IP3_uc010uvl.1_Silent_p.R327R	NM_015133	NP_055948	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting	326					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			breast(2)|central_nervous_system(1)	3																		---	---	---	---
HS3ST6	64711	broad.mit.edu	37	16	1961936	1961936	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:1961936G>A	uc002cnf.2	-	2	591	c.591C>T	c.(589-591)TAC>TAT	p.Y197Y		NM_001009606	NP_001009606	C9JH64	C9JH64_HUMAN	heparan sulfate (glucosamine)	197											0																		---	---	---	---
TBL3	10607	broad.mit.edu	37	16	2026277	2026277	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2026277C>T	uc002cnu.1	+	13	1356	c.1254C>T	c.(1252-1254)TCC>TCT	p.S418S	TBL3_uc002cnv.1_Silent_p.S304S|TBL3_uc010bsb.1_Silent_p.S207S|TBL3_uc010bsc.1_Intron|TBL3_uc010uvt.1_5'UTR|TBL3_uc002cnw.1_5'Flank	NM_006453	NP_006444	Q12788	TBL3_HUMAN	transducin beta-like 3	418					G-protein signaling, coupled to cGMP nucleotide second messenger|rRNA processing	nucleolus|small-subunit processome	receptor signaling protein activity				0																		---	---	---	---
TSC2	7249	broad.mit.edu	37	16	2131669	2131669	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2131669G>A	uc002con.2	+	31	3790	c.3684G>A	c.(3682-3684)CTG>CTA	p.L1228L	TSC2_uc010bsd.2_Silent_p.L1228L|TSC2_uc002coo.2_Silent_p.L1184L|TSC2_uc010uvv.1_Silent_p.L1148L|TSC2_uc010uvw.1_Silent_p.L1136L|TSC2_uc002cop.2_Silent_p.L984L|TSC2_uc002coq.2_5'Flank|TSC2_uc002cor.2_5'Flank	NM_000548	NP_000539	P49815	TSC2_HUMAN	tuberous sclerosis 2 isoform 1	1228					cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			central_nervous_system(4)|lung(3)|ovary(2)|pancreas(1)	10		Hepatocellular(780;0.0202)						D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				---	---	---	---
TSC2	7249	broad.mit.edu	37	16	2136307	2136307	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2136307G>A	uc002con.2	+	37	4882	c.4776G>A	c.(4774-4776)GTG>GTA	p.V1592V	TSC2_uc010bsd.2_Silent_p.V1569V|TSC2_uc002coo.2_Silent_p.V1525V|TSC2_uc010uvv.1_Silent_p.V1489V|TSC2_uc010uvw.1_Silent_p.V1477V|TSC2_uc002cop.2_Silent_p.V1348V|TSC2_uc002coq.2_Silent_p.V367V|TSC2_uc002cor.2_Silent_p.V293V	NM_000548	NP_000539	P49815	TSC2_HUMAN	tuberous sclerosis 2 isoform 1	1592	Rap-GAP.				cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			central_nervous_system(4)|lung(3)|ovary(2)|pancreas(1)	10		Hepatocellular(780;0.0202)						D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				---	---	---	---
MLST8	64223	broad.mit.edu	37	16	2259357	2259357	+	3'UTR	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2259357G>T	uc002coz.2	+	9					MLST8_uc002cpa.2_3'UTR|MLST8_uc002cpb.2_3'UTR|MLST8_uc010uvx.1_3'UTR|MLST8_uc002cpc.2_3'UTR|MLST8_uc002cpd.2_3'UTR|MLST8_uc002cpe.2_3'UTR|MLST8_uc002cpg.2_3'UTR|MLST8_uc002cph.2_RNA|MLST8_uc002cpf.2_3'UTR|C16orf79_uc002cpi.1_3'UTR	NM_022372	NP_071767			G protein beta subunit-like						insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|T cell costimulation	cytosol	protein binding				0																		---	---	---	---
C16orf79	283870	broad.mit.edu	37	16	2260588	2260588	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2260588G>C	uc010bsh.2	-	2	292	c.115C>G	c.(115-117)CTG>GTG	p.L39V	C16orf79_uc002cpi.1_Missense_Mutation_p.L39V	NM_182563	NP_872369	Q6PL45	CP079_HUMAN	hypothetical protein LOC283870	39	Poly-Leu.|Helical; (Potential).					integral to membrane				central_nervous_system(1)	1																		---	---	---	---
PDPK1	5170	broad.mit.edu	37	16	2636711	2636711	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2636711A>G	uc002cqs.2	+	11	1304	c.1160A>G	c.(1159-1161)CAG>CGG	p.Q387R	PDPK1_uc002cqt.2_Missense_Mutation_p.Q260R|PDPK1_uc010bsn.2_Missense_Mutation_p.Q387R|PDPK1_uc002cqu.2_Missense_Mutation_p.Q360R	NM_002613	NP_002604	O15530	PDPK1_HUMAN	3-phosphoinositide dependent protein kinase-1	387					actin cytoskeleton organization|activation of protein kinase B activity|insulin receptor signaling pathway|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|peptidyl-threonine phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|synaptic transmission|T cell costimulation|T cell receptor signaling pathway	cytosol|nucleoplasm|plasma membrane	3-phosphoinositide-dependent protein kinase activity|ATP binding			central_nervous_system(2)|ovary(1)	3		Ovarian(90;0.17)			Celecoxib(DB00482)													---	---	---	---
SRRM2	23524	broad.mit.edu	37	16	2809655	2809655	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2809655C>A	uc002crk.2	+	9	1375	c.826C>A	c.(826-828)CGC>AGC	p.R276S	SRRM2_uc002crj.1_Missense_Mutation_p.R180S|SRRM2_uc002crl.1_Missense_Mutation_p.R276S|SRRM2_uc010bsu.1_Missense_Mutation_p.R180S	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	276	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4																		---	---	---	---
PRSS22	64063	broad.mit.edu	37	16	2906205	2906205	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2906205G>A	uc002cry.1	-	3	225	c.159C>T	c.(157-159)GGC>GGT	p.G53G	PRSS22_uc002crz.1_Silent_p.G53G	NM_022119	NP_071402	Q9GZN4	BSSP4_HUMAN	protease, serine, 22 precursor	53	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)	1																		---	---	---	---
FLYWCH1	84256	broad.mit.edu	37	16	2987260	2987260	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2987260G>T	uc002csd.2	+	7	2015	c.1652G>T	c.(1651-1653)CGC>CTC	p.R551L	FLYWCH1_uc002csb.2_Missense_Mutation_p.R550L|FLYWCH1_uc002csc.2_Missense_Mutation_p.R550L|FLYWCH1_uc010bsv.2_Missense_Mutation_p.R275L|FLYWCH1_uc002cse.2_Missense_Mutation_p.R6L	NM_032296	NP_115672	Q4VC44	FWCH1_HUMAN	FLYWCH-type zinc finger 1 isoform a	551	FLYWCH-type 4.					nucleus	DNA binding|metal ion binding				0																		---	---	---	---
ZNF205	7755	broad.mit.edu	37	16	3169648	3169648	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3169648G>A	uc002cub.2	+	7	1122	c.987G>A	c.(985-987)ACG>ACA	p.T329T	ZNF205_uc002cua.2_Silent_p.T329T	NM_001042428	NP_001035893	O95201	ZN205_HUMAN	zinc finger protein 205	329	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding				0																		---	---	---	---
ZNF213	7760	broad.mit.edu	37	16	3191136	3191136	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3191136G>A	uc010uws.1	+	6	1615	c.1168G>A	c.(1168-1170)GAC>AAC	p.D390N	ZNF213_uc002cud.2_RNA|ZNF213_uc010btf.2_3'UTR|ZNF213_uc010bth.2_Missense_Mutation_p.D390N|ZNF213_uc010uwt.1_3'UTR	NM_004220	NP_004211	O14771	ZN213_HUMAN	zinc finger protein 213	390	C2H2-type 3.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0																		---	---	---	---
MEFV	4210	broad.mit.edu	37	16	3293377	3293377	+	Missense_Mutation	SNP	C	T	T	rs104895096		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3293377C>T	uc002cun.1	-	10	2150	c.2110G>A	c.(2110-2112)GTT>ATT	p.V704I		NM_000243	NP_000234	O15553	MEFV_HUMAN	Mediterranean fever protein	704	B30.2/SPRY.		V -> I (in arFMF).		inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|lung(1)	6					Colchicine(DB01394)													---	---	---	---
MEFV	4210	broad.mit.edu	37	16	3304678	3304678	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3304678G>A	uc002cun.1	-	2	430	c.390C>T	c.(388-390)AAC>AAT	p.N130N		NM_000243	NP_000234	O15553	MEFV_HUMAN	Mediterranean fever protein	130					inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|lung(1)	6					Colchicine(DB01394)													---	---	---	---
ZNF434	54925	broad.mit.edu	37	16	3434756	3434756	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3434756G>T	uc002cuz.2	-	5	1103	c.301C>A	c.(301-303)CTA>ATA	p.L101I	ZNF434_uc002cux.3_Missense_Mutation_p.L312I|ZNF434_uc010uwx.1_Missense_Mutation_p.L24I|ZNF434_uc002cuy.3_Missense_Mutation_p.L24I|ZNF434_uc010uwy.1_Missense_Mutation_p.L24I|ZNF434_uc010uwz.1_Missense_Mutation_p.L312I|ZNF434_uc010uxa.1_Missense_Mutation_p.L101I	NM_017810	NP_060280	Q9NX65	ZN434_HUMAN	zinc finger protein 434	101					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2																		---	---	---	---
NAT15	79903	broad.mit.edu	37	16	3529610	3529610	+	Intron	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3529610T>C	uc002cvh.3	+						NAT15_uc010uxb.1_Intron|NAT15_uc010btk.1_Intron|NAT15_uc010btl.2_Intron|NAT15_uc010btm.2_Intron|NAT15_uc010uxc.1_Intron|NAT15_uc010uxd.1_Intron|NAT15_uc010uxe.1_Intron|NAT15_uc002cvg.1_Intron	NM_001083601	NP_001077070			N-acetyltransferase 15								N-acetyltransferase activity				0																		---	---	---	---
BTBD12	84464	broad.mit.edu	37	16	3641099	3641099	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3641099T>C	uc002cvp.2	-	12	3167	c.2540A>G	c.(2539-2541)AAT>AGT	p.N847S		NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	847	Potential.|Interaction with PLK1 and TERF2-TERF2IP.|Glu-rich.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0													Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia				---	---	---	---
TRAP1	10131	broad.mit.edu	37	16	3726046	3726046	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3726046G>T	uc002cvt.3	-	7	894	c.805C>A	c.(805-807)CGG>AGG	p.R269R	TRAP1_uc002cvs.2_Silent_p.R60R|TRAP1_uc010uxf.1_Silent_p.R216R	NM_016292	NP_057376	Q12931	TRAP1_HUMAN	TNF receptor-associated protein 1 precursor	269					cellular response to oxidative stress|protein folding	mitochondrion	ATP binding|tumor necrosis factor receptor binding|unfolded protein binding			central_nervous_system(1)	1		Ovarian(90;0.0261)																---	---	---	---
CORO7	79585	broad.mit.edu	37	16	4409528	4409528	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:4409528G>T	uc002cwh.3	-	22	2323	c.2203C>A	c.(2203-2205)CTG>ATG	p.L735M	CORO7_uc002cwe.2_RNA|CORO7_uc002cwf.2_Missense_Mutation_p.L735M|CORO7_uc002cwg.3_Missense_Mutation_p.L515M|CORO7_uc010uxh.1_Missense_Mutation_p.L717M|CORO7_uc010uxi.1_Missense_Mutation_p.L650M|CORO7_uc002cwi.1_Missense_Mutation_p.L515M	NM_024535	NP_078811	P57737	CORO7_HUMAN	coronin 7	735	WD 8.					cytoplasmic membrane-bounded vesicle|cytosol|Golgi membrane|integral to membrane of membrane fraction|soluble fraction					0																OREG0023580	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
GLYR1	84656	broad.mit.edu	37	16	4861222	4861222	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:4861222C>T	uc002cxx.3	-	15	1573	c.1536G>A	c.(1534-1536)GCG>GCA	p.A512A	GLYR1_uc002cxy.2_RNA|GLYR1_uc002cxz.1_Silent_p.A426A|GLYR1_uc002cya.2_Silent_p.A506A|GLYR1_uc010uxv.1_Silent_p.A431A	NM_032569	NP_115958	Q49A26	GLYR1_HUMAN	cytokine-like nuclear factor n-pac	512					pentose-phosphate shunt	nucleus	coenzyme binding|DNA binding|methylated histone residue binding|phosphogluconate dehydrogenase (decarboxylating) activity				0																		---	---	---	---
ALG1	56052	broad.mit.edu	37	16	5123189	5123189	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:5123189G>A	uc002cym.2	+	3	363	c.322G>A	c.(322-324)GTA>ATA	p.V108I	ALG1_uc002cyj.2_5'UTR|ALG1_uc002cyn.2_Missense_Mutation_p.V108I|ALG1_uc010bue.2_5'UTR|ALG1_uc010uxy.1_5'UTR	NM_019109	NP_061982	Q9BT22	ALG1_HUMAN	beta-1,4-mannosyltransferase	108	Lumenal (Potential).				dolichol-linked oligosaccharide biosynthetic process|lipopolysaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	chitobiosyldiphosphodolichol beta-mannosyltransferase activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(90;0.0164)																---	---	---	---
ALG1	56052	broad.mit.edu	37	16	5129739	5129739	+	Intron	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:5129739C>T	uc002cym.2	+						ALG1_uc002cyj.2_Intron|ALG1_uc002cyn.2_Intron|ALG1_uc010bue.2_Intron|ALG1_uc010uxy.1_Intron	NM_019109	NP_061982			beta-1,4-mannosyltransferase						dolichol-linked oligosaccharide biosynthetic process|lipopolysaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	chitobiosyldiphosphodolichol beta-mannosyltransferase activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(90;0.0164)																---	---	---	---
ALG1	56052	broad.mit.edu	37	16	5129771	5129771	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:5129771T>C	uc002cym.2	+	9	965	c.924T>C	c.(922-924)GAT>GAC	p.D308D	ALG1_uc002cyj.2_Silent_p.D197D|ALG1_uc002cyn.2_Silent_p.D308D|ALG1_uc010bue.2_Silent_p.D197D|ALG1_uc010uxy.1_Silent_p.D197D	NM_019109	NP_061982	Q9BT22	ALG1_HUMAN	beta-1,4-mannosyltransferase	308	Lumenal (Potential).				dolichol-linked oligosaccharide biosynthetic process|lipopolysaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	chitobiosyldiphosphodolichol beta-mannosyltransferase activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(90;0.0164)																---	---	---	---
USP7	7874	broad.mit.edu	37	16	9024253	9024253	+	Silent	SNP	C	A	A	rs62031302		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:9024253C>A	uc002czl.2	-	2	280	c.81G>T	c.(79-81)GCG>GCT	p.A27A	USP7_uc010uyk.1_5'UTR|USP7_uc010uyj.1_5'UTR|USP7_uc002czk.2_Silent_p.A11A|USP7_uc010uyl.1_RNA	NM_003470	NP_003461	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7	27	Interaction with TSPYL5.				interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity	p.A27G(1)		ovary(3)	3																		---	---	---	---
TXNDC11	51061	broad.mit.edu	37	16	11792005	11792005	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:11792005G>A	uc010buu.1	-	8	1226	c.1164C>T	c.(1162-1164)GCC>GCT	p.A388A	TXNDC11_uc002dbg.1_Silent_p.A361A	NM_015914	NP_056998	Q6PKC3	TXD11_HUMAN	thioredoxin domain containing 11	388					cell redox homeostasis	endoplasmic reticulum membrane|integral to membrane					0																		---	---	---	---
ABCC1	4363	broad.mit.edu	37	16	16130382	16130382	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:16130382T>C	uc010bvi.2	+	7	906	c.731T>C	c.(730-732)TTA>TCA	p.L244S	ABCC1_uc010bvj.2_Missense_Mutation_p.L244S|ABCC1_uc010bvk.2_Missense_Mutation_p.L244S|ABCC1_uc010bvl.2_Missense_Mutation_p.L244S|ABCC1_uc010bvm.2_Missense_Mutation_p.L244S|ABCC1_uc002del.3_Missense_Mutation_p.L128S|ABCC1_uc010bvn.2_Missense_Mutation_p.L107S	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	244	Cytoplasmic.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)													---	---	---	---
ACSM2A	123876	broad.mit.edu	37	16	20491904	20491904	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:20491904G>A	uc010bwe.2	+	12	1530	c.1291G>A	c.(1291-1293)GAC>AAC	p.D431N	ACSM2A_uc010vax.1_Missense_Mutation_p.D352N|ACSM2A_uc002dhf.3_Missense_Mutation_p.D431N|ACSM2A_uc002dhg.3_Missense_Mutation_p.D431N|ACSM2A_uc010vay.1_Missense_Mutation_p.D352N|ACSM2A_uc002dhh.3_Missense_Mutation_p.D61N	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	431					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3																		---	---	---	---
DNAH3	55567	broad.mit.edu	37	16	21123071	21123071	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:21123071C>T	uc010vbe.1	-	14	1975	c.1975G>A	c.(1975-1977)GTG>ATG	p.V659M	DNAH3_uc002die.2_Missense_Mutation_p.V599M	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	659	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)														---	---	---	---
UQCRC2	7385	broad.mit.edu	37	16	21974140	21974140	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:21974140G>A	uc002djx.2	+	6	584	c.448G>A	c.(448-450)GAA>AAA	p.E150K	UQCRC2_uc002djy.2_Missense_Mutation_p.E150K|UQCRC2_uc010bxa.2_RNA|UQCRC2_uc002djz.1_Missense_Mutation_p.E17K	NM_003366	NP_003357	P22695	QCR2_HUMAN	ubiquinol-cytochrome c reductase core protein II	150					aerobic respiration|oxidative phosphorylation|proteolysis|respiratory electron transport chain|transport		metalloendopeptidase activity|zinc ion binding			large_intestine(2)	2				GBM - Glioblastoma multiforme(48;0.0264)														---	---	---	---
EEF2K	29904	broad.mit.edu	37	16	22291579	22291579	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:22291579T>C	uc002dki.2	+	17	2435	c.1950T>C	c.(1948-1950)TGT>TGC	p.C650C	EEF2K_uc002dkh.2_RNA	NM_013302	NP_037434	O00418	EF2K_HUMAN	elongation factor-2 kinase	650					insulin receptor signaling pathway|translational elongation	cytosol	ATP binding|calcium ion binding|calmodulin binding|elongation factor-2 kinase activity|translation factor activity, nucleic acid binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(48;0.0223)														---	---	---	---
PLK1	5347	broad.mit.edu	37	16	23701317	23701317	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:23701317A>G	uc002dlz.1	+	10	1798	c.1745A>G	c.(1744-1746)TAC>TGC	p.Y582C		NM_005030	NP_005021	P53350	PLK1_HUMAN	polo-like kinase 1	582	POLO box 2.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G2/M transition DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic prophase|negative regulation of cyclin-dependent protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|protein localization to chromatin|protein ubiquitination|regulation of mitotic anaphase|regulation of protein binding	centrosome|condensed nuclear chromosome outer kinetochore|cytosol|nucleoplasm|spindle microtubule|spindle midzone|spindle pole	anaphase-promoting complex binding|ATP binding|polo kinase kinase activity|protein kinase binding			lung(1)|skin(1)	2				GBM - Glioblastoma multiforme(48;0.0156)														---	---	---	---
ERN2	10595	broad.mit.edu	37	16	23702743	23702743	+	Missense_Mutation	SNP	C	T	T	rs144279415	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:23702743C>T	uc002dma.3	-	20	2693	c.2524G>A	c.(2524-2526)GTC>ATC	p.V842I	ERN2_uc010bxp.2_Missense_Mutation_p.V790I	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2	794	KEN.|Cytoplasmic (Potential).				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)														---	---	---	---
TNRC6A	27327	broad.mit.edu	37	16	24803029	24803029	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:24803029G>T	uc002dmm.2	+	6	3180	c.3066G>T	c.(3064-3066)TGG>TGT	p.W1022C	TNRC6A_uc010bxs.2_Missense_Mutation_p.W769C|TNRC6A_uc010vcc.1_Missense_Mutation_p.W769C|TNRC6A_uc002dmn.2_Missense_Mutation_p.W769C|TNRC6A_uc002dmo.2_Missense_Mutation_p.W769C	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1022	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)														---	---	---	---
TNRC6A	27327	broad.mit.edu	37	16	24815588	24815588	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:24815588G>A	uc002dmm.2	+	12	3899	c.3785G>A	c.(3784-3786)CGG>CAG	p.R1262Q	TNRC6A_uc010bxs.2_Missense_Mutation_p.R1009Q|TNRC6A_uc002dmn.2_Missense_Mutation_p.R1009Q|TNRC6A_uc002dmo.2_Missense_Mutation_p.R950Q|TNRC6A_uc002dmp.2_5'UTR|TNRC6A_uc002dmq.2_5'Flank	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1262	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)														---	---	---	---
TNRC6A	27327	broad.mit.edu	37	16	24817552	24817552	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:24817552C>T	uc002dmm.2	+	16	4391	c.4277C>T	c.(4276-4278)GCG>GTG	p.A1426V	TNRC6A_uc010bxs.2_Missense_Mutation_p.A1173V|TNRC6A_uc002dmn.2_Missense_Mutation_p.A1124V|TNRC6A_uc002dmo.2_Missense_Mutation_p.A1065V|TNRC6A_uc002dmp.2_Missense_Mutation_p.A27V|TNRC6A_uc002dmq.2_Missense_Mutation_p.A93V	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1426					negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)														---	---	---	---
JMJD5	79831	broad.mit.edu	37	16	27232030	27232030	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:27232030G>T	uc002doh.2	+	8	1412	c.1230G>T	c.(1228-1230)TCG>TCT	p.S410S	JMJD5_uc010vcn.1_Silent_p.S448S|JMJD5_uc010bxw.2_Silent_p.S214S|JMJD5_uc010bxx.2_RNA	NM_024773	NP_079049	Q8N371	KDM8_HUMAN	jumonji domain containing 5 isoform 2	410	JmjC.				G2/M transition of mitotic cell cycle|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	chromatin binding|histone demethylase activity (H3-K36 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(2)|upper_aerodigestive_tract(1)	3																		---	---	---	---
KIAA0556	23247	broad.mit.edu	37	16	27751366	27751366	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:27751366T>C	uc002dow.2	+	15	1772	c.1748T>C	c.(1747-1749)CTT>CCT	p.L583P		NM_015202	NP_056017	O60303	K0556_HUMAN	hypothetical protein LOC23247	583										ovary(4)|large_intestine(2)|upper_aerodigestive_tract(1)|skin(1)	8																		---	---	---	---
Unknown	0	broad.mit.edu	37	16	28603773	28603773	+	Intron	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:28603773C>T	uc010vct.1	-						SULT1A2_uc002dqg.1_Intron|SULT1A2_uc002dqh.1_Intron					RecName: Full=Nuclear pore complex-interacting protein-like 2; Flags: Precursor;																														---	---	---	---
Unknown	0	broad.mit.edu	37	16	28617566	28617566	+	Intron	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:28617566C>T	uc010vct.1	-						SULT1A1_uc002dqi.2_Intron|SULT1A1_uc002dqj.2_Intron|SULT1A1_uc002dqk.2_Intron|SULT1A1_uc002dql.2_Intron|SULT1A1_uc002dqm.2_Intron|SULT1A1_uc002dqn.2_Intron|SULT1A1_uc002dqo.2_Intron|SULT1A1_uc002dqp.2_Intron					RecName: Full=Nuclear pore complex-interacting protein-like 2; Flags: Precursor;																														---	---	---	---
TUFM	7284	broad.mit.edu	37	16	28855429	28855429	+	Intron	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:28855429C>T	uc002drh.2	-						uc010vct.1_Intron|SH2B1_uc002dri.2_5'Flank	NM_003321	NP_003312			Tu translation elongation factor, mitochondrial							mitochondrial nucleoid	GTP binding|GTPase activity|protein binding|translation elongation factor activity			ovary(1)	1																		---	---	---	---
SRCAP	10847	broad.mit.edu	37	16	30750430	30750430	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:30750430C>T	uc002dze.1	+	34	9454	c.9069C>T	c.(9067-9069)CCC>CCT	p.P3023P	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Silent_p.P2818P	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	3023	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)															---	---	---	---
SLC5A2	6524	broad.mit.edu	37	16	31499991	31499991	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:31499991C>T	uc002ecf.3	+	10	1197	c.1178C>T	c.(1177-1179)TCG>TTG	p.S393L	SLC5A2_uc010car.2_Intron|C16orf58_uc002ecg.2_RNA	NM_003041	NP_003032	P31639	SC5A2_HUMAN	solute carrier family 5 (sodium/glucose	393	Extracellular (Potential).				carbohydrate metabolic process	integral to membrane	low-affinity glucose:sodium symporter activity			ovary(1)	1																		---	---	---	---
VPS35	55737	broad.mit.edu	37	16	46696158	46696158	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:46696158C>A	uc002eef.3	-	15	2163	c.2064G>T	c.(2062-2064)GAG>GAT	p.E688D	VPS35_uc002eed.2_Missense_Mutation_p.E509D|VPS35_uc002eee.2_Missense_Mutation_p.E649D	NM_018206	NP_060676	Q96QK1	VPS35_HUMAN	vacuolar protein sorting 35	688					protein transport|retrograde transport, endosome to Golgi	cytosol|endosome|membrane	protein binding				0		all_cancers(37;7.65e-05)|all_epithelial(9;0.000154)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)																---	---	---	---
NETO2	81831	broad.mit.edu	37	16	47165884	47165884	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:47165884G>A	uc002eer.1	-	2	472	c.87C>T	c.(85-87)ACC>ACT	p.T29T	NETO2_uc002ees.1_Silent_p.T29T	NM_018092	NP_060562	Q8NC67	NETO2_HUMAN	neuropilin- and tolloid-like protein 2	29	Extracellular (Potential).					integral to membrane	receptor activity				0		all_cancers(37;0.00114)|all_lung(18;0.00432)|Lung NSC(13;0.0384)|Breast(268;0.174)													HNSCC(25;0.065)			---	---	---	---
ABCC12	94160	broad.mit.edu	37	16	48139043	48139043	+	Intron	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:48139043G>A	uc002efc.1	-						ABCC12_uc002eey.1_Intron|ABCC12_uc002eez.1_Intron|ABCC12_uc002efa.1_Intron|ABCC12_uc002efb.1_Intron|ABCC12_uc002efd.1_Intron	NM_033226	NP_150229			ATP-binding cassette protein C12							integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)																---	---	---	---
ABCC11	85320	broad.mit.edu	37	16	48239325	48239325	+	Silent	SNP	G	T	T	rs142338810	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:48239325G>T	uc002eff.1	-	12	2154	c.1804C>A	c.(1804-1806)CGA>AGA	p.R602R	ABCC11_uc002efg.1_Silent_p.R602R|ABCC11_uc002efh.1_Silent_p.R602R|ABCC11_uc010vgk.1_RNA	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	602	ABC transporter 1.|Cytoplasmic (Potential).					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)												Cerumen_Type				---	---	---	---
ZNF423	23090	broad.mit.edu	37	16	49669784	49669784	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:49669784G>T	uc002efs.2	-	5	3577	c.3279C>A	c.(3277-3279)GCC>GCA	p.A1093A	ZNF423_uc010vgn.1_Silent_p.A976A	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	1093					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)																---	---	---	---
ZNF423	23090	broad.mit.edu	37	16	49670272	49670272	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:49670272T>C	uc002efs.2	-	5	3089	c.2791A>G	c.(2791-2793)AAG>GAG	p.K931E	ZNF423_uc010vgn.1_Missense_Mutation_p.K814E	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	931	C2H2-type 22.				cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)																---	---	---	---
SALL1	6299	broad.mit.edu	37	16	51175595	51175595	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:51175595C>A	uc010vgs.1	-	2	569	c.538G>T	c.(538-540)GGG>TGG	p.G180W	SALL1_uc010vgr.1_Missense_Mutation_p.G83W|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	180					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)															---	---	---	---
IRX6	79190	broad.mit.edu	37	16	55363169	55363169	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:55363169T>C	uc002ehy.2	+	5	1812	c.1279T>C	c.(1279-1281)TGC>CGC	p.C427R	IRX6_uc002ehx.2_Missense_Mutation_p.C427R	NM_024335	NP_077311	P78412	IRX6_HUMAN	iroquois homeobox protein 6	427						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(1)	6																		---	---	---	---
AMFR	267	broad.mit.edu	37	16	56396514	56396514	+	3'UTR	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:56396514C>T	uc002eiy.2	-	14					AMFR_uc002eiw.2_RNA|AMFR_uc002eix.2_3'UTR	NM_001144	NP_001135			autocrine motility factor receptor						endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|protein oligomerization|protein polyubiquitination	integral to endoplasmic reticulum membrane|integral to membrane of membrane fraction	protein binding|protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)	2																		---	---	---	---
MT2A	4502	broad.mit.edu	37	16	56643249	56643249	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:56643249T>C	uc002ejh.2	+	3	259	c.169T>C	c.(169-171)TGC>CGC	p.C57R	MT1A_uc002eji.2_Intron	NM_005953	NP_005944	P02795	MT2_HUMAN	metallothionein 2A	57	Alpha.	Divalent metal cation; cluster A.			cellular copper ion homeostasis|interferon-gamma-mediated signaling pathway		metal ion binding|protein binding				0																		---	---	---	---
NLRC5	84166	broad.mit.edu	37	16	57067548	57067548	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:57067548G>T	uc002ekk.1	+	12	2735	c.2510G>T	c.(2509-2511)AGG>ATG	p.R837M	NLRC5_uc010ccq.1_RNA|NLRC5_uc002ekn.2_Missense_Mutation_p.R586M|NLRC5_uc002ekl.2_Missense_Mutation_p.R642M|NLRC5_uc002ekm.2_Missense_Mutation_p.R642M|NLRC5_uc010ccr.1_RNA|NLRC5_uc010ccs.1_5'Flank	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	837					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)																---	---	---	---
CNOT1	23019	broad.mit.edu	37	16	58619303	58619303	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:58619303T>C	uc002env.2	-	8	1038	c.745A>G	c.(745-747)ACC>GCC	p.T249A	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Missense_Mutation_p.T249A|CNOT1_uc002enx.2_Missense_Mutation_p.T249A|CNOT1_uc002enz.1_Intron	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	249					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)														---	---	---	---
CDH11	1009	broad.mit.edu	37	16	64981761	64981761	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:64981761G>A	uc002eoi.2	-	13	2570	c.2136C>T	c.(2134-2136)CCC>CCT	p.P712P	CDH11_uc010cdn.2_RNA|CDH11_uc002eoj.2_3'UTR|CDH11_uc010vin.1_Silent_p.P586P	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	712	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)				T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			---	---	---	---
CMTM3	123920	broad.mit.edu	37	16	66643409	66643409	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:66643409G>A	uc002epu.2	+	4	634	c.375G>A	c.(373-375)TCG>TCA	p.S125S	CMTM3_uc002epv.2_Silent_p.S125S|CMTM3_uc002epw.2_Silent_p.S125S|CMTM3_uc002epx.2_Silent_p.S125S|CMTM3_uc002epy.2_RNA	NM_001048251	NP_001041716	Q96MX0	CKLF3_HUMAN	chemokine-like factor superfamily 3	125	MARVEL.				chemotaxis	extracellular space|integral to membrane	cytokine activity			central_nervous_system(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0671)|Epithelial(162;0.164)														---	---	---	---
CA7	766	broad.mit.edu	37	16	66880978	66880978	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:66880978G>A	uc002eqi.2	+	2	195	c.86G>A	c.(85-87)CGC>CAC	p.R29H	uc002eqh.2_Intron|CA7_uc002eqj.2_5'UTR	NM_005182	NP_005173	P43166	CAH7_HUMAN	carbonic anhydrase VII isoform 1	29					one-carbon metabolic process	cytoplasm	carbonate dehydratase activity|zinc ion binding				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.088)|Epithelial(162;0.204)														---	---	---	---
CES8	283848	broad.mit.edu	37	16	67040713	67040713	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67040713C>T	uc002eqv.2	+	11	1343	c.1300C>T	c.(1300-1302)CGC>TGC	p.R434C	CES8_uc010vix.1_Intron|CES8_uc002eqw.2_Intron|CES8_uc002eqy.2_Missense_Mutation_p.R406C|CES8_uc002eqx.2_Missense_Mutation_p.R310C|CES8_uc010viy.1_Intron|CES8_uc010viz.1_Missense_Mutation_p.R406C|CES8_uc002eqz.2_Intron	NM_173815	NP_776176	Q5XG92	EST4A_HUMAN	carboxylesterase 8 (putative)	504						extracellular region	carboxylesterase activity				0																		---	---	---	---
EXOC3L	283849	broad.mit.edu	37	16	67221443	67221443	+	Missense_Mutation	SNP	C	T	T	rs141744902	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67221443C>T	uc002erx.1	-	5	966	c.725G>A	c.(724-726)CGG>CAG	p.R242Q	EXOC3L_uc002erv.1_RNA|EXOC3L_uc002erw.1_Intron|EXOC3L_uc002ery.1_Missense_Mutation_p.R186Q|EXOC3L_uc010vje.1_Missense_Mutation_p.R181Q	NM_178516	NP_848611	Q86VI1	EX3L1_HUMAN	exocyst complex component 3-like	242	Mediates interaction with EXOC2, EXOC4 and EXOC5 (By similarity).				exocytosis|peptide hormone secretion	exocyst|stored secretory granule|transport vesicle					0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0021)|Epithelial(162;0.0073)|all cancers(182;0.0616)														---	---	---	---
PLEKHG4	25894	broad.mit.edu	37	16	67314806	67314806	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67314806G>A	uc002eso.3	+	3	3152	c.617G>A	c.(616-618)CGG>CAG	p.R206Q	PLEKHG4_uc002esp.3_Missense_Mutation_p.R13Q|PLEKHG4_uc002esq.3_Missense_Mutation_p.R206Q|PLEKHG4_uc002esr.1_Missense_Mutation_p.R54Q|PLEKHG4_uc010cef.2_Missense_Mutation_p.R206Q|PLEKHG4_uc002ess.3_Missense_Mutation_p.R206Q|PLEKHG4_uc010ceg.2_Missense_Mutation_p.R125Q	NM_015432	NP_056247	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G	206					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)|pancreas(1)	2				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)														---	---	---	---
HSD11B2	3291	broad.mit.edu	37	16	67470195	67470195	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67470195A>C	uc002etd.2	+	4	824	c.708A>C	c.(706-708)AAA>AAC	p.K236N		NM_000196	NP_000187	P80365	DHI2_HUMAN	hydroxysteroid (11-beta) dehydrogenase 2	236					glucocorticoid biosynthetic process	endoplasmic reticulum|microsome					0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0401)|Epithelial(162;0.0891)	NADH(DB00157)													---	---	---	---
ATP6V0D1	9114	broad.mit.edu	37	16	67477028	67477028	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67477028C>T	uc002ete.1	-	4	635	c.535G>A	c.(535-537)GAG>AAG	p.E179K	ATP6V0D1_uc010vjo.1_Missense_Mutation_p.E220K|ATP6V0D1_uc010vjn.1_Missense_Mutation_p.E102K	NM_004691	NP_004682	P61421	VA0D1_HUMAN	ATPase, H+ transporting, lysosomal, V0 subunit	179					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	endosome membrane|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase complex					0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0439)|Epithelial(162;0.101)														---	---	---	---
CTCF	10664	broad.mit.edu	37	16	67670738	67670738	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67670738G>A	uc002etl.2	+	11	2273	c.1983G>A	c.(1981-1983)CAG>CAA	p.Q661Q	CTCF_uc010cek.2_Silent_p.Q333Q|CTCF_uc002etm.1_Silent_p.Q150Q	NM_006565	NP_006556	P49711	CTCF_HUMAN	CCCTC-binding factor	661					chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)														---	---	---	---
RANBP10	57610	broad.mit.edu	37	16	67763281	67763281	+	Silent	SNP	G	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67763281G>C	uc002eud.2	-	10	1370	c.1254C>G	c.(1252-1254)TCC>TCG	p.S418S	RANBP10_uc010ceo.2_Silent_p.S189S|RANBP10_uc010vju.1_Silent_p.S362S|RANBP10_uc010vjv.1_Silent_p.S301S|RANBP10_uc010vjw.1_Silent_p.S79S	NM_020850	NP_065901	Q6VN20	RBP10_HUMAN	RAN binding protein 10	418	Ser-rich.									ovary(1)	1		Acute lymphoblastic leukemia(13;4.34e-06)|all_hematologic(13;0.000643)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00522)|Epithelial(162;0.025)|all cancers(182;0.157)														---	---	---	---
PSKH1	5681	broad.mit.edu	37	16	67943103	67943103	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67943103C>T	uc002euv.2	+	2	621	c.451C>T	c.(451-453)CGT>TGT	p.R151C	PSKH1_uc010cet.2_Missense_Mutation_p.R151C	NM_006742	NP_006733	P11801	KPSH1_HUMAN	protein serine kinase H1	151	Protein kinase.					endoplasmic reticulum membrane|Golgi apparatus|microtubule organizing center|nuclear speck|plasma membrane	ATP binding|protein serine/threonine kinase activity				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0044)|Epithelial(162;0.0197)|all cancers(182;0.128)														---	---	---	---
NFATC3	4775	broad.mit.edu	37	16	68156891	68156891	+	Silent	SNP	C	A	A	rs142644036	byFrequency	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:68156891C>A	uc002evo.1	+	2	1315	c.1105C>A	c.(1105-1107)CGG>AGG	p.R369R	NFATC3_uc010vkl.1_5'UTR|NFATC3_uc010vkm.1_5'UTR|NFATC3_uc010vkn.1_5'UTR|NFATC3_uc010vko.1_5'UTR|NFATC3_uc010vkp.1_5'UTR|NFATC3_uc010vkq.1_5'UTR|NFATC3_uc002evl.2_Intron|NFATC3_uc002evk.2_Silent_p.R369R|NFATC3_uc002evm.1_Silent_p.R369R|NFATC3_uc002evn.1_Silent_p.R369R|NFATC3_uc010vkr.1_5'UTR|NFATC3_uc010vks.1_5'UTR|NFATC3_uc010vkt.1_5'UTR|NFATC3_uc010vku.1_5'UTR|NFATC3_uc010vkv.1_5'UTR|NFATC3_uc010vkw.1_5'UTR|NFATC3_uc010vkx.1_5'UTR|NFATC3_uc010vky.1_5'UTR|NFATC3_uc010vkz.1_5'UTR|NFATC3_uc010vla.1_5'UTR|NFATC3_uc010vlb.1_5'UTR|NFATC3_uc010vlc.1_5'UTR	NM_173165	NP_775188	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells,	369					inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)														---	---	---	---
SLC7A6	9057	broad.mit.edu	37	16	68308738	68308738	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:68308738G>A	uc002evt.1	+	4	418	c.109G>A	c.(109-111)GAA>AAA	p.E37K	SLC7A6_uc010cfb.1_RNA|SLC7A6_uc002evu.1_Missense_Mutation_p.E37K|SLC7A6_uc002evv.1_RNA|SLC7A6_uc010cfc.1_RNA	NM_001076785	NP_001070253	Q92536	YLAT2_HUMAN	solute carrier family 7 (cationic amino acid	37	Cytoplasmic (Potential).				blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	basolateral plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|antiporter activity			central_nervous_system(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.034)|Epithelial(162;0.0948)														---	---	---	---
SMPD3	55512	broad.mit.edu	37	16	68405541	68405541	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:68405541C>T	uc002ewa.2	-	3	966	c.544G>A	c.(544-546)GCT>ACT	p.A182T	SMPD3_uc010cfe.2_Missense_Mutation_p.A182T|SMPD3_uc010vlh.1_Missense_Mutation_p.A182T	NM_018667	NP_061137	Q9NY59	NSMA2_HUMAN	neutral sphingomyelin phosphodiesterase 3	182	Lumenal (Potential).				cell cycle|multicellular organismal development|sphingomyelin catabolic process	Golgi membrane|integral to membrane|plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity			skin(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0184)|Epithelial(162;0.0785)	Phosphatidylserine(DB00144)													---	---	---	---
HAS3	3038	broad.mit.edu	37	16	69143627	69143627	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:69143627G>A	uc010cfh.2	+	2	553	c.329G>A	c.(328-330)CGC>CAC	p.R110H	HAS3_uc002ewk.2_Missense_Mutation_p.R110H|HAS3_uc010vlk.1_Missense_Mutation_p.R110H|HAS3_uc002ewl.2_Missense_Mutation_p.R110H	NM_005329	NP_005320	O00219	HAS3_HUMAN	hyaluronan synthase 3 isoform a	110	Cytoplasmic (Potential).				carbohydrate metabolic process	integral to plasma membrane	hyaluronan synthase activity				0		Ovarian(137;0.101)		OV - Ovarian serous cystadenocarcinoma(108;0.0694)														---	---	---	---
TERF2	7014	broad.mit.edu	37	16	69404408	69404408	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:69404408T>C	uc002exd.2	-	5	817	c.692A>G	c.(691-693)GAC>GGC	p.D231G	TERF2_uc002exe.2_Missense_Mutation_p.D231G	NM_005652	NP_005643	Q15554	TERF2_HUMAN	telomeric repeat binding factor 2	231	TRFH dimerization.				age-dependent telomere shortening|cell cycle|cellular senescence|negative regulation of telomere maintenance via semi-conservative replication|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|regulation of transcription, DNA-dependent|telomeric loop formation	Golgi apparatus|nuclear telomere cap complex|nucleoplasm	double-stranded telomeric DNA binding|protein C-terminus binding|protein homodimerization activity			lung(1)	1		Ovarian(137;0.101)																---	---	---	---
COG4	25839	broad.mit.edu	37	16	70517769	70517769	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:70517769C>T	uc002ezc.2	-	14	1825	c.1814G>A	c.(1813-1815)CGA>CAA	p.R605Q	COG4_uc002eza.2_5'UTR|COG4_uc002ezb.2_Missense_Mutation_p.R61Q|COG4_uc010cfu.2_RNA|COG4_uc002ezd.2_Missense_Mutation_p.R584Q|COG4_uc002eze.2_Missense_Mutation_p.R299Q	NM_015386	NP_056201	Q9H9E3	COG4_HUMAN	component of oligomeric golgi complex 4	601					Golgi organization|Golgi vesicle prefusion complex stabilization|protein transport|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding				0		Ovarian(137;0.0694)																---	---	---	---
SF3B3	23450	broad.mit.edu	37	16	70590798	70590798	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:70590798C>A	uc002ezf.2	+	15	2087	c.1876C>A	c.(1876-1878)CAA>AAA	p.Q626K		NM_012426	NP_036558	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3	626					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(1)	1		Ovarian(137;0.0694)																---	---	---	---
DHX38	9785	broad.mit.edu	37	16	72143405	72143405	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:72143405G>A	uc002fcb.2	+	25	3828	c.3473G>A	c.(3472-3474)CGG>CAG	p.R1158Q	DHX38_uc010vmp.1_Missense_Mutation_p.R470Q	NM_014003	NP_054722	Q92620	PRP16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 38	1158					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1		Ovarian(137;0.125)																---	---	---	---
ADAMTS18	170692	broad.mit.edu	37	16	77356327	77356327	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:77356327T>C	uc002ffc.3	-	14	2488	c.2069A>G	c.(2068-2070)AAC>AGC	p.N690S	ADAMTS18_uc010chc.1_Missense_Mutation_p.N278S|ADAMTS18_uc002ffe.1_Missense_Mutation_p.N386S	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	690	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18																		---	---	---	---
SLC38A8	146167	broad.mit.edu	37	16	84067036	84067036	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:84067036G>A	uc002fhg.1	-	3	427	c.427C>T	c.(427-429)CAG>TAG	p.Q143*		NM_001080442	NP_001073911	A6NNN8	S38A8_HUMAN	solute carrier family 38, member 8	143					amino acid transport|sodium ion transport	integral to membrane					0																		---	---	---	---
MBTPS1	8720	broad.mit.edu	37	16	84126839	84126839	+	Missense_Mutation	SNP	G	A	A	rs149564178	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:84126839G>A	uc002fhi.2	-	6	1302	c.800C>T	c.(799-801)GCT>GTT	p.A267V		NM_003791	NP_003782	Q14703	MBTP1_HUMAN	membrane-bound transcription factor site-1	267	Serine protease.|Lumenal (Potential).				cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			ovary(2)	2																		---	---	---	---
ANKRD11	29123	broad.mit.edu	37	16	89383423	89383423	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:89383423G>A	uc002fmx.1	-	3	466	c.5C>T	c.(4-6)CCC>CTC	p.P2L	ANKRD11_uc002fmy.1_Missense_Mutation_p.P2L|ANKRD11_uc002fnc.1_Missense_Mutation_p.P2L|ANKRD11_uc002fnd.2_5'UTR|ANKRD11_uc002fne.2_5'UTR|ANKRD11_uc002fng.1_Missense_Mutation_p.P2L|ANKRD11_uc002fnf.1_Missense_Mutation_p.P2L	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	2						nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)														---	---	---	---
FANCA	2175	broad.mit.edu	37	16	89857811	89857811	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:89857811C>A	uc002fou.1	-	14	1401	c.1359G>T	c.(1357-1359)AAG>AAT	p.K453N	FANCA_uc010vpn.1_Missense_Mutation_p.K453N	NM_000135	NP_000126	O15360	FANCA_HUMAN	Fanconi anemia, complementation group A isoform	453					DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)				D|Mis|N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				---	---	---	---
TUBB3	10381	broad.mit.edu	37	16	89999011	89999011	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:89999011C>T	uc002fph.1	+	2	155	c.90C>T	c.(88-90)ATC>ATT	p.I30I	TUBB3_uc002fpf.2_Silent_p.I377I|TUBB3_uc010ciz.1_5'UTR|TUBB3_uc010cja.1_RNA|TUBB3_uc002fpg.1_5'UTR|TUBB3_uc002fpi.1_5'UTR|TUBB3_uc002fpj.1_5'UTR|TUBB3_uc010cjb.1_5'UTR|TUBB3_uc002fpk.1_5'Flank	NM_006086	NP_006077	Q13509	TBB3_HUMAN	tubulin, beta, 4	30					'de novo' posttranslational protein folding|axon guidance|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(2)|pancreas(1)	3		all_cancers(9;1.69e-11)|Lung NSC(15;8.94e-06)|all_lung(18;1.39e-05)|all_neural(9;0.00581)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0273)														---	---	---	---
TUBB3	10381	broad.mit.edu	37	16	90001305	90001305	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:90001305C>T	uc002fph.1	+	4	511	c.446C>T	c.(445-447)ACG>ATG	p.T149M	TUBB3_uc002fpf.2_Missense_Mutation_p.T496M|TUBB3_uc010ciz.1_Missense_Mutation_p.T77M|TUBB3_uc002fpg.1_Missense_Mutation_p.T3M|TUBB3_uc002fpi.1_Missense_Mutation_p.T77M|TUBB3_uc002fpj.1_Missense_Mutation_p.T77M|TUBB3_uc010cjb.1_Missense_Mutation_p.T3M|TUBB3_uc002fpk.1_Missense_Mutation_p.T3M	NM_006086	NP_006077	Q13509	TBB3_HUMAN	tubulin, beta, 4	149					'de novo' posttranslational protein folding|axon guidance|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(2)|pancreas(1)	3		all_cancers(9;1.69e-11)|Lung NSC(15;8.94e-06)|all_lung(18;1.39e-05)|all_neural(9;0.00581)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0273)														---	---	---	---
GLOD4	51031	broad.mit.edu	37	17	685454	685454	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:685454T>C	uc002frv.2	-	1	118	c.42A>G	c.(40-42)GGA>GGG	p.G14G	GLOD4_uc002fru.2_Silent_p.G14G|GLOD4_uc010vqc.1_5'UTR|RNMTL1_uc002frw.2_5'Flank	NM_016080	NP_057164	Q9HC38	GLOD4_HUMAN	glyoxalase domain containing 4	14						mitochondrion					0				UCEC - Uterine corpus endometrioid carcinoma (25;0.022)														---	---	---	---
NXN	64359	broad.mit.edu	37	17	729260	729260	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:729260G>A	uc002fsa.2	-	2	511	c.419C>T	c.(418-420)GCC>GTC	p.A140V	NXN_uc002fsb.1_Missense_Mutation_p.A27V|NXN_uc002frz.2_5'UTR|NXN_uc010vqe.1_Missense_Mutation_p.A32V	NM_022463	NP_071908	Q6DKJ4	NXN_HUMAN	nucleoredoxin	140					cell differentiation|cell redox homeostasis|multicellular organismal development|Wnt receptor signaling pathway	cytosol|nucleus	protein-disulfide reductase activity			ovary(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (25;0.0237)														---	---	---	---
PRPF8	10594	broad.mit.edu	37	17	1557105	1557105	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:1557105G>T	uc002fte.2	-	38	6307	c.6193C>A	c.(6193-6195)CAG>AAG	p.Q2065K		NM_006445	NP_006436	Q6P2Q9	PRP8_HUMAN	U5 snRNP-specific protein	2065						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			lung(4)|ovary(2)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)														---	---	---	---
SGSM2	9905	broad.mit.edu	37	17	2282378	2282378	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:2282378C>T	uc002fun.3	+	22	2988	c.2813C>T	c.(2812-2814)GCC>GTC	p.A938V	SGSM2_uc002fum.3_Missense_Mutation_p.A983V|SGSM2_uc010vqw.1_Missense_Mutation_p.A938V|SGSM2_uc002fup.1_Missense_Mutation_p.A116V|SGSM2_uc002fuq.2_Missense_Mutation_p.A100V	NM_001098509	NP_001091979	O43147	SGSM2_HUMAN	RUN and TBC1 domain containing 1 isoform 2	938	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0				Colorectal(2;5.15e-05)|READ - Rectum adenocarcinoma(2;0.000115)														---	---	---	---
METT10D	79066	broad.mit.edu	37	17	2323528	2323528	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:2323528C>A	uc002fut.2	-	10	1573	c.1425G>T	c.(1423-1425)GAG>GAT	p.E475D	METT10D_uc002fuu.3_RNA|METT10D_uc010cka.2_RNA|METT10D_uc002fuv.2_Intron|METT10D_uc010vqx.1_RNA|METT10D_uc010vqy.1_Missense_Mutation_p.E257D	NM_024086	NP_076991	Q86W50	MET16_HUMAN	methyltransferase 10 domain containing	475							methyltransferase activity				0																		---	---	---	---
OR1D4	8385	broad.mit.edu	37	17	2966340	2966340	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:2966340C>T	uc010vra.1	-	1	616	c.616G>A	c.(616-618)GCA>ACA	p.A206T		NM_003552	NP_003543			olfactory receptor, family 1, subfamily D,												0																		---	---	---	---
TRPV3	162514	broad.mit.edu	37	17	3417934	3417934	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:3417934G>A	uc002fvt.1	-	17	2553	c.2231C>T	c.(2230-2232)ACG>ATG	p.T744M	SPATA22_uc010vrg.1_5'Flank|TRPV3_uc002fvs.1_RNA|TRPV3_uc010vrh.1_Missense_Mutation_p.T728M|TRPV3_uc010vri.1_Missense_Mutation_p.T699M|TRPV3_uc010vrj.1_Missense_Mutation_p.T728M|TRPV3_uc010vrk.1_RNA|TRPV3_uc010vrl.1_Missense_Mutation_p.T728M|TRPV3_uc010vrm.1_RNA|TRPV3_uc002fvr.2_Missense_Mutation_p.T744M|TRPV3_uc002fvu.2_Missense_Mutation_p.T744M	NM_145068	NP_659505	Q8NET8	TRPV3_HUMAN	transient receptor potential cation channel,	744	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(4)	4					Menthol(DB00825)													---	---	---	---
CTNS	1497	broad.mit.edu	37	17	3560021	3560021	+	Missense_Mutation	SNP	G	A	A	rs113994208		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:3560021G>A	uc002fwb.2	+	9	1206	c.613G>A	c.(613-615)GAC>AAC	p.D205N	CTNS_uc002fwa.2_Missense_Mutation_p.D205N|CTNS_uc010ckj.2_Missense_Mutation_p.D205N|CTNS_uc010vrv.1_Missense_Mutation_p.D58N|CTNS_uc010vrw.1_Missense_Mutation_p.D97N	NM_004937	NP_004928	O60931	CTNS_HUMAN	cystinosin isoform 2	205	Lumenal (Potential).		Missing (in CTNS).|D -> N (in CTNS).		ATP metabolic process|brain development|cognition|glutathione metabolic process	integral to membrane|late endosome|lysosomal membrane	L-cystine transmembrane transporter activity				0				COAD - Colon adenocarcinoma(5;0.0829)	L-Cystine(DB00138)													---	---	---	---
P2RX1	5023	broad.mit.edu	37	17	3807613	3807613	+	Intron	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:3807613G>T	uc002fww.2	-							NM_002558	NP_002549			purinergic receptor P2X1						platelet activation	integral to plasma membrane	calcium channel activity|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity			ovary(1)|skin(1)	2				LUAD - Lung adenocarcinoma(2;1.9e-05)|Lung(3;0.0173)														---	---	---	---
CHRNE	1145	broad.mit.edu	37	17	4804184	4804184	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:4804184G>A	uc002fzk.1	-	8	832	c.821C>T	c.(820-822)ACG>ATG	p.T274M	C17orf107_uc002fzl.3_3'UTR	NM_000080	NP_000071	Q04844	ACHE_HUMAN	nicotinic acetylcholine receptor epsilon	274	Helical; (Potential).				muscle contraction|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0																		---	---	---	---
KIF1C	10749	broad.mit.edu	37	17	4907376	4907376	+	Intron	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:4907376C>T	uc002gan.1	+							NM_006612	NP_006603			kinesin family member 1C						microtubule-based movement|retrograde vesicle-mediated transport, Golgi to ER	endoplasmic reticulum|Golgi apparatus|microtubule	ATP binding|microtubule motor activity			breast(2)	2																		---	---	---	---
USP6	9098	broad.mit.edu	37	17	5049342	5049342	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:5049342C>A	uc002gau.1	+	28	4422	c.2192C>A	c.(2191-2193)CCT>CAT	p.P731H	USP6_uc002gav.1_Missense_Mutation_p.P731H|USP6_uc010ckz.1_Missense_Mutation_p.P414H	NM_004505	NP_004496	P35125	UBP6_HUMAN	ubiquitin specific protease 6	731					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)	5								T	COL1A1|CDH11|ZNF9|OMD	aneurysmal bone cysts								---	---	---	---
ZNF594	84622	broad.mit.edu	37	17	5086206	5086206	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:5086206C>T	uc010cla.1	-	2	1502	c.1346G>A	c.(1345-1347)AGA>AAA	p.R449K		NM_032530	NP_115919	Q96JF6	ZN594_HUMAN	zinc finger protein 594	449	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(1)	3																		---	---	---	---
NLRP1	22861	broad.mit.edu	37	17	5456824	5456824	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:5456824G>T	uc002gci.2	-	5	2965	c.2410C>A	c.(2410-2412)CTC>ATC	p.L804I	NLRP1_uc002gcg.1_Missense_Mutation_p.L804I|NLRP1_uc002gck.2_Missense_Mutation_p.L804I|NLRP1_uc002gcj.2_Missense_Mutation_p.L804I|NLRP1_uc002gcl.2_Missense_Mutation_p.L804I|NLRP1_uc002gch.3_Missense_Mutation_p.L804I|NLRP1_uc010clh.2_Missense_Mutation_p.L804I	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	804					defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)																---	---	---	---
AIPL1	23746	broad.mit.edu	37	17	6337403	6337403	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:6337403G>A	uc002gcp.2	-	2	207	c.112C>T	c.(112-114)CGC>TGC	p.R38C	AIPL1_uc002gcq.2_Intron|AIPL1_uc002gcr.2_Missense_Mutation_p.R38C|AIPL1_uc010clk.2_Intron|AIPL1_uc010cll.2_Missense_Mutation_p.R38C|AIPL1_uc002gcs.2_Missense_Mutation_p.R38C	NM_014336	NP_055151	Q9NZN9	AIPL1_HUMAN	aryl hydrocarbon receptor interacting	38					protein farnesylation|protein folding|visual perception	cytoplasm|nucleus	farnesylated protein binding|unfolded protein binding				0				COAD - Colon adenocarcinoma(228;0.141)														---	---	---	---
FAM64A	54478	broad.mit.edu	37	17	6351090	6351090	+	Intron	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:6351090A>G	uc002gcw.1	+						FAM64A_uc002gct.1_Missense_Mutation_p.Y201C|FAM64A_uc002gcu.1_Intron|FAM64A_uc002gcv.1_Missense_Mutation_p.Y232C|FAM64A_uc002gcx.1_Missense_Mutation_p.Y201C|FAM64A_uc002gcy.1_RNA|FAM64A_uc002gcz.1_RNA|FAM64A_uc002gda.1_Missense_Mutation_p.Y201C|FAM64A_uc002gdb.1_Missense_Mutation_p.Y201C	NM_019013	NP_061886			family with sequence similarity 64, member A							nucleolus	protein binding				0				COAD - Colon adenocarcinoma(228;0.141)														---	---	---	---
SLC16A11	162515	broad.mit.edu	37	17	6945418	6945418	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:6945418G>A	uc002gei.1	-	3	1421	c.1083C>T	c.(1081-1083)TTC>TTT	p.F361F		NM_153357	NP_699188	Q8NCK7	MOT11_HUMAN	solute carrier family 16, member 11	361	Extracellular (Potential).					integral to membrane|plasma membrane	symporter activity			ovary(1)	1																		---	---	---	---
DNAH2	146754	broad.mit.edu	37	17	7681430	7681430	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7681430G>A	uc002giu.1	+	33	5297	c.5283G>A	c.(5281-5283)ACG>ACA	p.T1761T		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	1761	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)																---	---	---	---
DNAH2	146754	broad.mit.edu	37	17	7701025	7701025	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7701025A>G	uc002giu.1	+	52	8122	c.8108A>G	c.(8107-8109)TAT>TGT	p.Y2703C		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	2703					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)																---	---	---	---
KCNAB3	9196	broad.mit.edu	37	17	7827318	7827318	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7827318G>A	uc002gjm.1	-	11	895	c.895C>T	c.(895-897)CGA>TGA	p.R299*	KCNAB3_uc010vul.1_RNA	NM_004732	NP_004723	O43448	KCAB3_HUMAN	potassium voltage-gated channel, shaker-related	299						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			ovary(1)	1		Prostate(122;0.157)																---	---	---	---
ALOX15B	247	broad.mit.edu	37	17	7942628	7942628	+	Intron	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7942628C>T	uc002gju.2	+						ALOX15B_uc002gjv.2_Intron|ALOX15B_uc002gjw.2_Intron|ALOX15B_uc010vun.1_Intron|ALOX15B_uc010cnp.2_Intron	NM_001141	NP_001132			arachidonate 15-lipoxygenase, second type						induction of apoptosis|leukotriene biosynthetic process|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of growth|prostate gland development|regulation of epithelial cell differentiation	cytoplasm	arachidonate 15-lipoxygenase activity|iron ion binding|lipoxygenase activity			ovary(1)	1																		---	---	---	---
PER1	5187	broad.mit.edu	37	17	8050660	8050660	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:8050660C>T	uc002gkd.2	-	13	1775	c.1537G>A	c.(1537-1539)GGC>AGC	p.G513S	PER1_uc010vuq.1_RNA|PER1_uc010vur.1_Missense_Mutation_p.G497S	NM_002616	NP_002607	O15534	PER1_HUMAN	period 1	513					circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			lung(2)|breast(2)|skin(2)|large_intestine(1)|ovary(1)|kidney(1)	9								T	ETV6	AML|CMML			Other_conserved_DNA_damage_response_genes					---	---	---	---
MYH10	4628	broad.mit.edu	37	17	8390804	8390804	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:8390804C>T	uc002gll.2	-	34	4996	c.4900G>A	c.(4900-4902)GAG>AAG	p.E1634K	MYH10_uc002glm.2_Missense_Mutation_p.E1665K|MYH10_uc010cnx.2_Missense_Mutation_p.E1643K	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	1634	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2																		---	---	---	---
MFSD6L	162387	broad.mit.edu	37	17	8700779	8700779	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:8700779A>G	uc002glp.1	-	1	1808	c.1660T>C	c.(1660-1662)TCG>CCG	p.S554P		NM_152599	NP_689812	Q8IWD5	MFS6L_HUMAN	major facilitator superfamily domain containing	554						integral to membrane				central_nervous_system(1)	1																		---	---	---	---
WDR16	146845	broad.mit.edu	37	17	9515752	9515752	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:9515752A>G	uc002gly.2	+	8	1050	c.981A>G	c.(979-981)ATA>ATG	p.I327M	WDR16_uc002glz.2_Missense_Mutation_p.I259M|WDR16_uc010coc.2_Missense_Mutation_p.I337M	NM_145054	NP_659491	Q8N1V2	WDR16_HUMAN	WD40-repeat protein upregulated in HCC isoform	327	WD 4.					cytoplasm|intracellular membrane-bounded organelle	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4																		---	---	---	---
USP43	124739	broad.mit.edu	37	17	9631968	9631968	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:9631968T>C	uc010cod.2	+	15	3033	c.3033T>C	c.(3031-3033)AAT>AAC	p.N1011N	USP43_uc002gma.3_Silent_p.N700N|USP43_uc010vva.1_Silent_p.N1006N|USP43_uc010coe.2_Silent_p.N808N|USP43_uc002gmc.3_Silent_p.N523N	NM_153210	NP_694942	Q70EL4	UBP43_HUMAN	ubiquitin specific protease 43	1011					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5																		---	---	---	---
DHRS7C	201140	broad.mit.edu	37	17	9684848	9684848	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:9684848C>T	uc010vvb.1	-	2	218	c.218G>A	c.(217-219)AGG>AAG	p.R73K	DHRS7C_uc010cof.2_Missense_Mutation_p.R73K	NM_001105571	NP_001099041	A6NNS2	DRS7C_HUMAN	dehydrogenase/reductase (SDR family) member 7C	73						extracellular region	binding|oxidoreductase activity				0																		---	---	---	---
MYH3	4621	broad.mit.edu	37	17	10532979	10532979	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:10532979C>T	uc002gmq.1	-	39	5808	c.5731G>A	c.(5731-5733)GCG>ACG	p.A1911T		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	1911	Potential.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7																		---	---	---	---
MYH3	4621	broad.mit.edu	37	17	10533718	10533718	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:10533718G>A	uc002gmq.1	-	36	5421	c.5344C>T	c.(5344-5346)CGG>TGG	p.R1782W		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	1782	Potential.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7																		---	---	---	---
MYH3	4621	broad.mit.edu	37	17	10535909	10535909	+	Missense_Mutation	SNP	G	A	A	rs141020227		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:10535909G>A	uc002gmq.1	-	33	4917	c.4840C>T	c.(4840-4842)CGG>TGG	p.R1614W		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	1614	Potential.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7																		---	---	---	---
MYH3	4621	broad.mit.edu	37	17	10542774	10542774	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:10542774C>A	uc002gmq.1	-	23	3020	c.2943G>T	c.(2941-2943)GAG>GAT	p.E981D		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	981	Potential.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7																		---	---	---	---
MYH3	4621	broad.mit.edu	37	17	10553010	10553010	+	Intron	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:10553010G>T	uc002gmq.1	-							NM_002470	NP_002461			myosin, heavy chain 3, skeletal muscle,						muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7																		---	---	---	---
MYOCD	93649	broad.mit.edu	37	17	12655775	12655775	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:12655775G>A	uc002gnn.2	+	10	1469	c.1170G>A	c.(1168-1170)GTG>GTA	p.V390V	MYOCD_uc002gno.2_Silent_p.V390V|MYOCD_uc002gnp.1_Silent_p.V294V|MYOCD_uc002gnq.2_Silent_p.V109V	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	390	SAP.				cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)														---	---	---	---
RICH2	9912	broad.mit.edu	37	17	12888089	12888089	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:12888089G>A	uc002gnr.3	+	20	2508	c.2181G>A	c.(2179-2181)CGG>CGA	p.R727R	RICH2_uc010vvk.1_Silent_p.R727R|RICH2_uc010vvl.1_Silent_p.R721R|RICH2_uc002gns.3_Silent_p.R521R|RICH2_uc010vvm.1_Silent_p.R721R|RICH2_uc010vvn.1_RNA	NM_014859	NP_055674	Q17R89	RHG44_HUMAN	Rho GTPase-activating protein RICH2	727					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0																		---	---	---	---
PMP22	5376	broad.mit.edu	37	17	15134228	15134228	+	3'UTR	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:15134228G>T	uc002goj.2	-	4					PMP22_uc002gok.2_3'UTR|PMP22_uc002gol.2_3'UTR	NM_153322	NP_696997			peripheral myelin protein 22						peripheral nervous system development|synaptic transmission	integral to membrane					0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0884)|BRCA - Breast invasive adenocarcinoma(8;4.92e-06)														---	---	---	---
TRIM16	10626	broad.mit.edu	37	17	15516026	15516026	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:15516026A>G	uc002gor.1	-	11	2378	c.2041T>C	c.(2041-2043)TTG>CTG	p.L681L	CDRT1_uc002gov.3_Silent_p.L371L			O95361	TRI16_HUMAN	SubName: Full=Putative uncharacterized protein; Flags: Fragment;	Error:Variant_position_missing_in_O95361_after_alignment					histone H3 acetylation|histone H4 acetylation|positive regulation of interleukin-1 beta secretion|positive regulation of keratinocyte differentiation|positive regulation of retinoic acid receptor signaling pathway|positive regulation of transcription, DNA-dependent|response to growth hormone stimulus|response to organophosphorus|response to retinoic acid	cytoplasm|plasma membrane|PML body	DNA binding|interleukin-1 binding|NACHT domain binding|zinc ion binding			ovary(2)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (92;0.0839)|Epithelial(1;8.4e-29)|all cancers(1;3.06e-28)|Colorectal(1;1.57e-19)|OV - Ovarian serous cystadenocarcinoma(1;6.1e-17)|COAD - Colon adenocarcinoma(1;3.38e-12)|READ - Rectum adenocarcinoma(2;1.46e-05)|BRCA - Breast invasive adenocarcinoma(8;0.0559)														---	---	---	---
ZNF624	57547	broad.mit.edu	37	17	16526349	16526349	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:16526349G>A	uc010cpi.1	-	6	1934	c.1851C>T	c.(1849-1851)TGC>TGT	p.C617C		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	617	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)														---	---	---	---
PEMT	10400	broad.mit.edu	37	17	17480330	17480330	+	5'UTR	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:17480330G>A	uc002grj.2	-	2					PEMT_uc002grk.2_5'UTR|PEMT_uc002grl.2_Silent_p.C36C|PEMT_uc010vwx.1_Silent_p.C36C	NM_148173	NP_680478			phosphatidylethanolamine N-methyltransferase						cell proliferation|phosphatidylcholine biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial membrane	phosphatidylethanolamine N-methyltransferase activity				0				Colorectal(2;0.0157)|READ - Rectum adenocarcinoma(2;0.0891)														---	---	---	---
RAI1	10743	broad.mit.edu	37	17	17701059	17701059	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:17701059G>A	uc002grm.2	+	3	5266	c.4797G>A	c.(4795-4797)GTG>GTA	p.V1599V	RAI1_uc002grn.1_Silent_p.V1599V	NM_030665	NP_109590	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	1599						cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)|skin(1)	2				READ - Rectum adenocarcinoma(1115;0.0276)														---	---	---	---
MYO15A	51168	broad.mit.edu	37	17	18053803	18053803	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:18053803G>T	uc010vxh.1	+	35	7611	c.7273G>T	c.(7273-7275)GGC>TGC	p.G2425C		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	2425	Tail.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)																	---	---	---	---
TOP3A	7156	broad.mit.edu	37	17	18181552	18181552	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:18181552C>G	uc002gsx.1	-	18	2493	c.2264G>C	c.(2263-2265)GGC>GCC	p.G755A	TOP3A_uc010cpz.1_Missense_Mutation_p.G207A|TOP3A_uc010vxr.1_Missense_Mutation_p.G285A|TOP3A_uc002gsw.1_Missense_Mutation_p.G207A|TOP3A_uc010vxs.1_Missense_Mutation_p.G653A	NM_004618	NP_004609	Q13472	TOP3A_HUMAN	topoisomerase (DNA) III alpha	755					DNA topological change|meiosis	chromosome|PML body	ATP binding|DNA topoisomerase type I activity|protein binding|zinc ion binding			skin(3)	3																		---	---	---	---
CCDC144B	284047	broad.mit.edu	37	17	18511227	18511227	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:18511227C>T	uc002gub.1	-	4	806	c.721G>A	c.(721-723)GAA>AAA	p.E241K	CCDC144B_uc002gua.3_RNA|CCDC144B_uc010vyc.1_RNA|CCDC144B_uc002guc.1_Missense_Mutation_p.E240K	NM_182568	NP_872374			coiled-coil domain containing 144B											ovary(1)|skin(1)	2																		---	---	---	---
CCDC144NL	339184	broad.mit.edu	37	17	20799228	20799228	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:20799228A>G	uc002gyf.2	-	1	226	c.106T>C	c.(106-108)TGG>CGG	p.W36R	uc002gyg.1_Intron|uc002gyh.1_Intron	NM_001004306	NP_001004306	Q6NUI1	C144L_HUMAN	coiled-coil domain containing 144 family,	36											0																		---	---	---	---
KSR1	8844	broad.mit.edu	37	17	25935009	25935009	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:25935009G>A	uc010crg.2	+	16	2164	c.1719G>A	c.(1717-1719)ACG>ACA	p.T573T	KSR1_uc002gzm.2_Silent_p.T352T|KSR1_uc002gzn.2_5'Flank	NM_014238	NP_055053	Q8IVT5	KSR1_HUMAN	kinase suppressor of ras	708	Protein kinase.				Ras protein signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|central_nervous_system(1)	4	Lung NSC(42;0.00836)		BRCA - Breast invasive adenocarcinoma(3;0.00122)	UCEC - Uterine corpus endometrioid carcinoma (53;0.168)														---	---	---	---
KIAA0100	9703	broad.mit.edu	37	17	26961642	26961642	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:26961642A>G	uc002hbu.2	-	16	3062	c.2963T>C	c.(2962-2964)GTA>GCA	p.V988A		NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	988						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)																	---	---	---	---
TLCD1	116238	broad.mit.edu	37	17	27051645	27051645	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:27051645A>G	uc002hco.2	-	4	742	c.627T>C	c.(625-627)GGT>GGC	p.G209G	TLCD1_uc010waw.1_Silent_p.G162G	NM_138463	NP_612472	Q96CP7	TLCD1_HUMAN	TLC domain containing 1 isoform 1	209	TLC.|Helical; (Potential).					integral to membrane					0	Lung NSC(42;0.00431)																	---	---	---	---
SSH2	85464	broad.mit.edu	37	17	28030050	28030050	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:28030050A>G	uc002heo.1	-	3	138	c.138T>C	c.(136-138)GGT>GGC	p.G46G	SSH2_uc010wbh.1_Silent_p.G73G|SSH2_uc002hep.1_Silent_p.G46G|SSH2_uc002heq.2_Silent_p.G53G|SSH2_uc002her.2_Silent_p.G46G|SSH2_uc010csc.1_Silent_p.G46G	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	slingshot 2	46					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(2)	2																		---	---	---	---
SLC6A4	6532	broad.mit.edu	37	17	28548741	28548741	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:28548741C>A	uc002hey.3	-	3	780	c.236G>T	c.(235-237)CGG>CTG	p.R79L		NM_001045	NP_001036	P31645	SC6A4_HUMAN	solute carrier family 6 member 4	79	Cytoplasmic (Potential).				response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity			skin(3)|ovary(1)	4					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)													---	---	---	---
ATAD5	79915	broad.mit.edu	37	17	29161389	29161389	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:29161389A>G	uc002hfs.1	+	2	636	c.290A>G	c.(289-291)GAC>GGC	p.D97G	ATAD5_uc002hft.1_5'UTR	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	97					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)																---	---	---	---
ATAD5	79915	broad.mit.edu	37	17	29162120	29162120	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:29162120C>A	uc002hfs.1	+	2	1367	c.1021C>A	c.(1021-1023)CGA>AGA	p.R341R	ATAD5_uc002hft.1_Silent_p.R238R	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	341					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)																---	---	---	---
PSMD11	5717	broad.mit.edu	37	17	30771615	30771615	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:30771615A>T	uc010cta.1	+	1	114	c.74A>T	c.(73-75)GAC>GTC	p.D25V	PSMD11_uc010wbz.1_Missense_Mutation_p.D25V|PSMD11_uc002hhm.2_Missense_Mutation_p.D25V	NM_002815	NP_002806	O00231	PSD11_HUMAN	proteasome 26S non-ATPase subunit 11	25					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding			ovary(1)	1		Breast(31;0.159)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.109)															---	---	---	---
TMEM132E	124842	broad.mit.edu	37	17	32953298	32953298	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:32953298C>T	uc002hif.2	+	2	548	c.220C>T	c.(220-222)CAG>TAG	p.Q74*		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	74	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)														---	---	---	---
LIG3	3980	broad.mit.edu	37	17	33319045	33319045	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:33319045C>T	uc002hik.1	+	7	1385	c.1277C>T	c.(1276-1278)GCA>GTA	p.A426V	LIG3_uc002hij.2_Missense_Mutation_p.A426V|LIG3_uc010cth.1_Missense_Mutation_p.A435V	NM_013975	NP_039269	P49916	DNLI3_HUMAN	ligase III, DNA, ATP-dependent isoform alpha	426					base-excision repair|cell division|DNA ligation involved in DNA repair|DNA replication|reciprocal meiotic recombination|spermatogenesis	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|protein binding|zinc ion binding			skin(3)|lung(2)|ovary(2)|large_intestine(1)|pancreas(1)	9		Ovarian(249;0.17)			Bleomycin(DB00290)								Other_BER_factors					---	---	---	---
FNDC8	54752	broad.mit.edu	37	17	33454302	33454302	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:33454302A>G	uc002hix.2	+	2	533	c.451A>G	c.(451-453)AGG>GGG	p.R151G		NM_017559	NP_060029	Q8TC99	FNDC8_HUMAN	fibronectin type III domain containing 8	151										ovary(2)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.022)														---	---	---	---
SLFN11	91607	broad.mit.edu	37	17	33679860	33679860	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:33679860A>G	uc010ctp.2	-	7	2663	c.2221T>C	c.(2221-2223)TTA>CTA	p.L741L	SLFN11_uc010ctq.2_Silent_p.L741L|SLFN11_uc002hjh.3_Silent_p.L741L|SLFN11_uc002hjg.3_Silent_p.L741L|SLFN11_uc010ctr.2_Silent_p.L741L	NM_001104588	NP_001098058	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	741						nucleus	ATP binding			large_intestine(1)|ovary(1)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)														---	---	---	---
GGNBP2	79893	broad.mit.edu	37	17	34941792	34941792	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:34941792T>C	uc002hnb.2	+	10	1527	c.1278T>C	c.(1276-1278)ACT>ACC	p.T426T	GGNBP2_uc002hna.2_Silent_p.T426T|GGNBP2_uc002hnc.1_Silent_p.T255T	NM_024835	NP_079111	Q9H3C7	GGNB2_HUMAN	zinc finger protein 403	426					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasmic membrane-bounded vesicle				ovary(2)	2		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)														---	---	---	---
ACACA	31	broad.mit.edu	37	17	35518796	35518796	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:35518796G>A	uc002hnm.2	-	42	5328	c.5137C>T	c.(5137-5139)CGC>TGC	p.R1713C	ACACA_uc002hnk.2_Missense_Mutation_p.R1635C|ACACA_uc002hnl.2_Missense_Mutation_p.R1655C|ACACA_uc002hnn.2_Missense_Mutation_p.R1713C|ACACA_uc002hno.2_Missense_Mutation_p.R1750C|ACACA_uc010cuy.2_Missense_Mutation_p.R358C|ACACA_uc010wdc.1_Translation_Start_Site	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	1713	Carboxyltransferase.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)													---	---	---	---
CDK12	51755	broad.mit.edu	37	17	37627441	37627441	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:37627441A>G	uc010cvv.2	+	2	1942	c.1356A>G	c.(1354-1356)AAA>AAG	p.K452K	CDK12_uc010wef.1_Silent_p.K451K|CDK12_uc002hrw.3_Silent_p.K452K	NM_016507	NP_057591	Q9NYV4	CDK12_HUMAN	Cdc2-related kinase, arginine/serine-rich	452					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			ovary(10)|lung(4)|breast(2)|skin(2)|large_intestine(1)	19															TCGA Ovarian(9;0.13)			---	---	---	---
CDK12	51755	broad.mit.edu	37	17	37667883	37667883	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:37667883G>T	uc010cvv.2	+	8	3354	c.2768G>T	c.(2767-2769)GGA>GTA	p.G923V	CDK12_uc010wef.1_Missense_Mutation_p.G922V|CDK12_uc002hrw.3_Missense_Mutation_p.G923V	NM_016507	NP_057591	Q9NYV4	CDK12_HUMAN	Cdc2-related kinase, arginine/serine-rich	923	Protein kinase.				mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			ovary(10)|lung(4)|breast(2)|skin(2)|large_intestine(1)	19															TCGA Ovarian(9;0.13)			---	---	---	---
WIPF2	147179	broad.mit.edu	37	17	38421184	38421184	+	Silent	SNP	T	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:38421184T>G	uc002hug.1	+	5	996	c.756T>G	c.(754-756)CCT>CCG	p.P252P	WIPF2_uc002huh.1_Silent_p.P102P|WIPF2_uc010cww.1_Silent_p.P102P|WIPF2_uc002hui.1_Silent_p.P252P|WIPF2_uc010cwx.1_Intron|WIPF2_uc010cwy.1_Silent_p.P252P	NM_133264	NP_573571	Q8TF74	WIPF2_HUMAN	WIRE protein	252	Poly-Pro.					cytoplasm|cytoskeleton	actin binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	3															HNSCC(43;0.11)			---	---	---	---
SMARCE1	6605	broad.mit.edu	37	17	38788517	38788517	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:38788517A>T	uc002hux.2	-	8	768	c.644T>A	c.(643-645)GTT>GAT	p.V215D	SMARCE1_uc010wff.1_Missense_Mutation_p.V180D|SMARCE1_uc010wfg.1_Missense_Mutation_p.V145D|SMARCE1_uc002huy.2_Missense_Mutation_p.V180D|SMARCE1_uc010wfh.1_Missense_Mutation_p.V145D|SMARCE1_uc010wfi.1_Missense_Mutation_p.V197D	NM_003079	NP_003070	Q969G3	SMCE1_HUMAN	SWI/SNF-related matrix-associated	215					chromatin modification|negative regulation of transcription, DNA-dependent|nervous system development|nucleosome disassembly|regulation of transcription from RNA polymerase II promoter	nBAF complex|npBAF complex|nuclear chromosome|SWI/SNF complex|transcriptional repressor complex	chromatin binding|DNA binding|N-acetyltransferase activity|protein binding|protein N-terminus binding|transcription coactivator activity				0		Breast(137;0.000812)																---	---	---	---
KRTAP9-8	83901	broad.mit.edu	37	17	39394622	39394622	+	Missense_Mutation	SNP	C	T	T	rs75361905		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:39394622C>T	uc002hwh.3	+	1	353	c.319C>T	c.(319-321)CAC>TAC	p.H107Y	KRTAP9-9_uc010wfq.1_Intron	NM_031963	NP_114169	Q9BYQ0	KRA98_HUMAN	keratin associated protein 9.8	107	15 X 5 AA repeats of C-C-[RQVSGE]- [SPSNQ]-[TASPI].					keratin filament				ovary(1)	1		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)															---	---	---	---
KRT33A	3883	broad.mit.edu	37	17	39502761	39502761	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:39502761G>A	uc002hwk.1	-	6	1073	c.1036C>T	c.(1036-1038)CGG>TGG	p.R346W		NM_004138	NP_004129	O76009	KT33A_HUMAN	keratin 33A	346	Coil 2.|Rod.					intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000496)																---	---	---	---
STAT3	6774	broad.mit.edu	37	17	40467787	40467787	+	Silent	SNP	C	T	T	rs147202525		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40467787C>T	uc002hzl.1	-	24	2529	c.2289G>A	c.(2287-2289)TCG>TCA	p.S763S	STAT3_uc002hzk.1_3'UTR|STAT3_uc002hzm.1_Silent_p.S762S|STAT3_uc010wgh.1_Silent_p.S665S|STAT3_uc002hzn.1_Silent_p.S763S|STAT3_uc010cyf.1_3'UTR	NM_139276	NP_644805	P40763	STAT3_HUMAN	signal transducer and activator of transcription	763					cellular component movement|eating behavior|eye photoreceptor cell differentiation|glucose homeostasis|interleukin-6-mediated signaling pathway|interspecies interaction between organisms|JAK-STAT cascade involved in growth hormone signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein import into nucleus|response to estradiol stimulus|sexual reproduction|temperature homeostasis	cytosol|nucleus|plasma membrane	calcium ion binding|ligand-regulated transcription factor activity|protein dimerization activity|protein kinase binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			ovary(1)|lung(1)|breast(1)|central_nervous_system(1)	4		all_cancers(22;1.39e-06)|all_epithelial(22;2.95e-05)|Breast(137;0.000135)		BRCA - Breast invasive adenocarcinoma(366;0.139)										Hyperimmunoglobulin_E_Recurrent_Infection_Syndrome				---	---	---	---
PTRF	284119	broad.mit.edu	37	17	40575031	40575031	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40575031C>T	uc002hzo.2	-	1	244	c.85G>A	c.(85-87)GCT>ACT	p.A29T	PTRF_uc010wgi.1_Missense_Mutation_p.A29T	NM_012232	NP_036364	Q6NZI2	PTRF_HUMAN	polymerase I and transcript release factor	29					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription initiation from RNA polymerase I promoter	caveola|cytosol|endoplasmic reticulum|microsome|mitochondrion|nucleoplasm	protein binding|rRNA primary transcript binding			breast(1)	1		all_cancers(22;0.00146)|Breast(137;0.00116)|all_epithelial(22;0.0134)		BRCA - Breast invasive adenocarcinoma(366;0.193)														---	---	---	---
PLEKHH3	79990	broad.mit.edu	37	17	40822025	40822025	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40822025G>A	uc002iau.2	-	11	2391	c.1924C>T	c.(1924-1926)CGA>TGA	p.R642*	PLEKHH3_uc010cyl.1_RNA|PLEKHH3_uc002iat.1_RNA|PLEKHH3_uc002iav.2_RNA|PLEKHH3_uc010cym.1_Nonsense_Mutation_p.R3*|PLEKHH3_uc002iaw.2_Nonsense_Mutation_p.R639*	NM_024927	NP_079203	Q7Z736	PKHH3_HUMAN	pleckstrin homology domain containing, family H	642	FERM.				signal transduction	cytoskeleton				large_intestine(1)|ovary(1)	2		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.14)														---	---	---	---
WNK4	65266	broad.mit.edu	37	17	40940391	40940391	+	Missense_Mutation	SNP	G	A	A	rs146190504		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40940391G>A	uc002ibj.2	+	10	2027	c.2006G>A	c.(2005-2007)CGG>CAG	p.R669Q	WNK4_uc010wgx.1_Missense_Mutation_p.R333Q|WNK4_uc002ibk.1_Missense_Mutation_p.R441Q|WNK4_uc010wgy.1_Missense_Mutation_p.R13Q	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	669					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)														---	---	---	---
BRCA1	672	broad.mit.edu	37	17	41234588	41234588	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:41234588C>A	uc002icq.2	-	12	4422	c.4190G>T	c.(4189-4191)AGG>ATG	p.R1397M	BRCA1_uc010whp.1_Missense_Mutation_p.R247M|BRCA1_uc010whl.1_Missense_Mutation_p.R294M|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Missense_Mutation_p.R1326M|BRCA1_uc002icu.2_Missense_Mutation_p.R294M|BRCA1_uc010cyx.2_Missense_Mutation_p.R1350M|BRCA1_uc002ict.2_Missense_Mutation_p.R1397M|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Missense_Mutation_p.R126M|BRCA1_uc002idc.1_Missense_Mutation_p.R293M|BRCA1_uc010whr.1_Missense_Mutation_p.R247M	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	1397	Interaction with PALB2.				androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)				D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			---	---	---	---
BRCA1	672	broad.mit.edu	37	17	41244577	41244577	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:41244577T>G	uc002icq.2	-	10	3203	c.2971A>C	c.(2971-2973)AAA>CAA	p.K991Q	BRCA1_uc010whp.1_Intron|BRCA1_uc010whl.1_Intron|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Missense_Mutation_p.K920Q|BRCA1_uc002icu.2_Intron|BRCA1_uc010cyx.2_Missense_Mutation_p.K944Q|BRCA1_uc002ict.2_Missense_Mutation_p.K991Q|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Intron|BRCA1_uc002idc.1_Intron|BRCA1_uc010whr.1_Intron|BRCA1_uc002idd.2_Missense_Mutation_p.K991Q|BRCA1_uc002ide.1_Missense_Mutation_p.K822Q|BRCA1_uc010cyy.1_Missense_Mutation_p.K991Q|BRCA1_uc010whs.1_Missense_Mutation_p.K991Q|BRCA1_uc010cyz.2_Missense_Mutation_p.K944Q|BRCA1_uc010cza.2_Missense_Mutation_p.K965Q|BRCA1_uc010wht.1_Missense_Mutation_p.K695Q	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	991					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)				D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			---	---	---	---
GPATCH8	23131	broad.mit.edu	37	17	42477222	42477222	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:42477222G>T	uc002igw.1	-	8	2287	c.2223C>A	c.(2221-2223)CCC>CCA	p.P741P	GPATCH8_uc002igv.1_Silent_p.P663P|GPATCH8_uc010wiz.1_Silent_p.P663P	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	741						intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)														---	---	---	---
C17orf46	124783	broad.mit.edu	37	17	43334552	43334552	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:43334552G>A	uc002iis.1	-	2	132	c.36C>T	c.(34-36)TGC>TGT	p.C12C	LOC100133991_uc010dah.2_Intron|C17orf46_uc010wjk.1_5'UTR	NM_152343	NP_689556	Q96LK8	CQ046_HUMAN	hypothetical protein LOC124783	12										large_intestine(1)|ovary(1)	2																		---	---	---	---
PLEKHM1	9842	broad.mit.edu	37	17	43545824	43545824	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:43545824C>A	uc002ija.2	-	5	1229	c.1059G>T	c.(1057-1059)GAG>GAT	p.E353D	PLEKHM1_uc010wjm.1_Missense_Mutation_p.E325D|PLEKHM1_uc002ijb.2_Intron|PLEKHM1_uc010wjn.1_Missense_Mutation_p.E302D	NM_014798	NP_055613	Q9Y4G2	PKHM1_HUMAN	pleckstrin homology domain containing, family M	353					intracellular signal transduction	cytoplasm	metal ion binding				0	Renal(3;0.0405)																	---	---	---	---
KIAA1267	284058	broad.mit.edu	37	17	44115895	44115895	+	Intron	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:44115895G>T	uc002ikb.2	-						KIAA1267_uc002ikc.2_Intron|KIAA1267_uc002ikd.2_Intron|KIAA1267_uc010dav.2_Intron|KIAA1267_uc010wkb.1_Intron|KIAA1267_uc010wkc.1_Intron	NM_015443	NP_056258			hypothetical protein LOC284058							MLL1 complex	protein binding			skin(2)	2		Melanoma(429;0.211)																---	---	---	---
WNT9B	7484	broad.mit.edu	37	17	44952494	44952494	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:44952494C>T	uc002ikw.1	+	3	399	c.362C>T	c.(361-363)GCG>GTG	p.A121V	WNT9B_uc002ikx.1_Missense_Mutation_p.A121V	NM_003396	NP_003387	O14905	WNT9B_HUMAN	wingless-type MMTV integration site family,	121					anterior/posterior pattern formation|axis specification|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|collecting duct development|cornea development in camera-type eye|endoderm development|establishment of planar polarity involved in nephron morphogenesis|kidney rudiment formation|male genitalia development|mesonephric duct formation|metanephric tubule development|neuron differentiation|palate development|regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|uterus morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway|Wnt receptor signaling pathway, planar cell polarity pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding			lung(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.0257)															---	---	---	---
WNT9B	7484	broad.mit.edu	37	17	44952641	44952641	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:44952641C>T	uc002ikw.1	+	3	546	c.509C>T	c.(508-510)ACC>ATC	p.T170I	WNT9B_uc002ikx.1_Missense_Mutation_p.T170I	NM_003396	NP_003387	O14905	WNT9B_HUMAN	wingless-type MMTV integration site family,	170					anterior/posterior pattern formation|axis specification|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|collecting duct development|cornea development in camera-type eye|endoderm development|establishment of planar polarity involved in nephron morphogenesis|kidney rudiment formation|male genitalia development|mesonephric duct formation|metanephric tubule development|neuron differentiation|palate development|regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|uterus morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway|Wnt receptor signaling pathway, planar cell polarity pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding			lung(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.0257)															---	---	---	---
SP6	80320	broad.mit.edu	37	17	45924731	45924731	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:45924731G>A	uc002img.1	-	2	1397	c.1065C>T	c.(1063-1065)GGC>GGT	p.G355G	SP6_uc002imh.1_Silent_p.G355G	NM_199262	NP_954871	Q3SY56	SP6_HUMAN	Sp6 transcription factor	355					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1																		---	---	---	---
ITGA3	3675	broad.mit.edu	37	17	48148781	48148781	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:48148781G>T	uc010dbl.2	+	6	1322	c.858G>T	c.(856-858)CAG>CAT	p.Q286H	ITGA3_uc010dbm.2_Missense_Mutation_p.Q286H	NM_002204	NP_002195	P26006	ITA3_HUMAN	integrin alpha 3 isoform a precursor	286	FG-GAP 4.|Extracellular (Potential).				blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|leukocyte migration	cell surface|integrin complex	protein binding|receptor activity			ovary(2)|pancreas(1)	3																		---	---	---	---
BZRAP1	9256	broad.mit.edu	37	17	56382987	56382987	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:56382987G>A	uc002ivx.3	-	28	6146	c.5275C>T	c.(5275-5277)CCC>TCC	p.P1759S	BZRAP1_uc002ivv.2_5'Flank|BZRAP1_uc002ivw.2_5'UTR|BZRAP1_uc010dcs.2_Missense_Mutation_p.P1699S|BZRAP1_uc010wnt.1_Missense_Mutation_p.P1750S	NM_004758	NP_004749	O95153	RIMB1_HUMAN	peripheral benzodiazepine receptor-associated	1759						mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)																	---	---	---	---
CLTC	1213	broad.mit.edu	37	17	57752157	57752157	+	Silent	SNP	T	C	C	rs139004755		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:57752157T>C	uc002ixq.1	+	16	2957	c.2514T>C	c.(2512-2514)GGT>GGC	p.G838G	CLTC_uc002ixp.2_Silent_p.G838G|CLTC_uc002ixr.1_Silent_p.G842G	NM_004859	NP_004850	Q00610	CLH1_HUMAN	clathrin heavy chain 1	838	Heavy chain arm.|Proximal segment.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	haematopoietic_and_lymphoid_tissue(33)|soft_tissue(11)|kidney(2)|ovary(1)|breast(1)	48	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)							T	ALK|TFE3	ALCL|renal 								---	---	---	---
USP32	84669	broad.mit.edu	37	17	58289376	58289376	+	Intron	SNP	G	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:58289376G>C	uc002iyo.1	-						USP32_uc002iyn.1_Intron	NM_032582	NP_115971			ubiquitin specific protease 32						protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)															---	---	---	---
CCDC47	57003	broad.mit.edu	37	17	61829373	61829373	+	Missense_Mutation	SNP	C	A	A	rs144077995		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:61829373C>A	uc002jbs.3	-	12	1634	c.1298G>T	c.(1297-1299)CGG>CTG	p.R433L	CCDC47_uc010ddx.2_Missense_Mutation_p.R433L|CCDC47_uc002jbt.2_Missense_Mutation_p.R433L	NM_020198	NP_064583	Q96A33	CCD47_HUMAN	coiled-coil domain containing 47 precursor	433						integral to membrane	protein binding				0																		---	---	---	---
LRRC37A3	374819	broad.mit.edu	37	17	62852005	62852005	+	Missense_Mutation	SNP	G	C	C	rs140806799	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:62852005G>C	uc002jey.2	-	13	5343	c.4812C>G	c.(4810-4812)ATC>ATG	p.I1604M	LRRC37A3_uc010wqg.1_Missense_Mutation_p.I722M|LRRC37A3_uc002jex.1_Missense_Mutation_p.I581M|LRRC37A3_uc010wqf.1_Missense_Mutation_p.I642M	NM_199340	NP_955372	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	1604	Cytoplasmic (Potential).					integral to membrane					0																		---	---	---	---
CACNG5	27091	broad.mit.edu	37	17	64881122	64881122	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:64881122A>G	uc010wqi.1	+	6	830	c.593A>G	c.(592-594)TAC>TGC	p.Y198C	CACNG5_uc010wqj.1_Missense_Mutation_p.Y198C	NM_145811	NP_665810	Q9UF02	CCG5_HUMAN	voltage-dependent calcium channel gamma-5	198				SAGVMSVYLFMKRYTAEDMYRPHPGFYRPRLSNCSDYSGQF LHPDAWVRGRSPSDISSEASLQMNSNYPALLKCPDYDQMSS SPC -> VKPVTLSMDRLGLGTAPLSRGEWGWGRRDIPQPF WTPDHPLYFPSSSQNVSLSYLSGSPPARMSPGPCSCPHVHF PPHSSCVLCRPQPREMRQAPAASPSSAVFSL (in Ref. 1; AAF03089).	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|postsynaptic density|postsynaptic membrane	voltage-gated calcium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(6;1.61e-08)															---	---	---	---
HELZ	9931	broad.mit.edu	37	17	65103454	65103454	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:65103454T>C	uc010wqk.1	-	31	5262	c.5075A>G	c.(5074-5076)AAT>AGT	p.N1692S	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.N1691S	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)																	---	---	---	---
HELZ	9931	broad.mit.edu	37	17	65124763	65124763	+	Intron	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:65124763T>C	uc010wqk.1	-						HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Intron	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)																	---	---	---	---
BPTF	2186	broad.mit.edu	37	17	65905705	65905705	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:65905705T>C	uc002jgf.2	+	10	2881	c.2820T>C	c.(2818-2820)AAT>AAC	p.N940N	BPTF_uc002jge.2_Silent_p.N1066N	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	1066					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)															---	---	---	---
ABCA8	10351	broad.mit.edu	37	17	66898920	66898920	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:66898920A>G	uc002jhp.2	-	19	2757	c.2578T>C	c.(2578-2580)TAT>CAT	p.Y860H	ABCA8_uc002jhq.2_Missense_Mutation_p.Y900H|ABCA8_uc010wqq.1_Missense_Mutation_p.Y900H|ABCA8_uc010wqr.1_Missense_Mutation_p.Y839H|ABCA8_uc002jhr.2_Missense_Mutation_p.Y900H	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	860						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)																	---	---	---	---
ABCA10	10349	broad.mit.edu	37	17	67186554	67186554	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:67186554T>C	uc010dfa.1	-	19	2955	c.2076A>G	c.(2074-2076)ACA>ACG	p.T692T	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfb.1_Silent_p.T293T	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	692					transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)																	---	---	---	---
COG1	9382	broad.mit.edu	37	17	71197647	71197647	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:71197647G>A	uc002jjg.2	+	7	1717	c.1681G>A	c.(1681-1683)GCA>ACA	p.A561T	COG1_uc002jjh.2_Missense_Mutation_p.A561T|COG1_uc002jjf.1_Missense_Mutation_p.A561T	NM_018714	NP_061184	Q8WTW3	COG1_HUMAN	component of oligomeric golgi complex 1	561					Golgi organization|intra-Golgi vesicle-mediated transport|protein transport	Golgi membrane|Golgi transport complex	protein binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(166;0.197)															---	---	---	---
SDK2	54549	broad.mit.edu	37	17	71389790	71389790	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:71389790G>A	uc010dfm.2	-	27	3807	c.3807C>T	c.(3805-3807)TAC>TAT	p.Y1269Y	SDK2_uc002jjt.3_Silent_p.Y428Y|SDK2_uc010dfn.2_Silent_p.Y948Y	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	1269	Fibronectin type-III 7.|Extracellular (Potential).				cell adhesion	integral to membrane				ovary(2)	2																		---	---	---	---
CD300LD	100131439	broad.mit.edu	37	17	72576253	72576253	+	Intron	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:72576253C>A	uc002jkz.2	-							NM_001115152	NP_001108624			CD300 molecule-like family member d precursor							integral to membrane|plasma membrane	receptor activity				0																		---	---	---	---
TMEM104	54868	broad.mit.edu	37	17	72832458	72832458	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:72832458A>G	uc002jls.3	+	10	1285	c.1123A>G	c.(1123-1125)ACC>GCC	p.T375A	TMEM104_uc010wrf.1_Intron|TMEM104_uc010wrg.1_Intron|TMEM104_uc010dfx.2_Missense_Mutation_p.T375A	NM_017728	NP_060198	Q8NE00	TM104_HUMAN	transmembrane protein 104	375	Helical; (Potential).					integral to membrane					0	all_lung(278;0.23)																	---	---	---	---
TRIM47	91107	broad.mit.edu	37	17	73870851	73870851	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73870851A>G	uc002jpw.2	-	6	1657	c.1630T>C	c.(1630-1632)TTC>CTC	p.F544L	TRIM47_uc002jpv.2_Missense_Mutation_p.F306L	NM_033452	NP_258411	Q96LD4	TRI47_HUMAN	tripartite motif-containing 47	544	B30.2/SPRY.					cytoplasm|nucleus	zinc ion binding			ovary(2)|prostate(1)|lung(1)|breast(1)	5			Epithelial(20;4.23e-06)|all cancers(21;5.24e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00092)|LUSC - Lung squamous cell carcinoma(166;0.154)															---	---	---	---
GALR2	8811	broad.mit.edu	37	17	74072970	74072970	+	Missense_Mutation	SNP	G	A	A	rs142971884		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:74072970G>A	uc002jqm.1	+	2	703	c.622G>A	c.(622-624)GCG>ACG	p.A208T	ZACN_uc002jqn.2_5'Flank|ZACN_uc002jqo.2_5'Flank|ZACN_uc010dgu.2_5'Flank	NM_003857	NP_003848	O43603	GALR2_HUMAN	galanin receptor 2	208	Helical; Name=5; (Potential).				digestion|elevation of cytosolic calcium ion concentration|feeding behavior|learning or memory|muscle contraction	integral to membrane|plasma membrane	galanin receptor activity				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	17	74557778	74557778	+	Intron	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:74557778T>C	uc002jsa.1	+						uc002jsb.1_Intron|uc002jsc.1_Intron|SNORD1C_uc002jsd.1_Intron|SNORD1A_uc002jse.2_RNA					Homo sapiens primary hepatoblastoma cDNA, clone:HKMT0728, full insert sequence.																														---	---	---	---
SEC14L1	6397	broad.mit.edu	37	17	75196727	75196727	+	Silent	SNP	C	T	T	rs143920033		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:75196727C>T	uc002jto.2	+	9	1248	c.981C>T	c.(979-981)TAC>TAT	p.Y327Y	SEC14L1_uc010dhc.2_Silent_p.Y327Y|SEC14L1_uc010wth.1_Silent_p.Y327Y|SEC14L1_uc002jtm.2_Silent_p.Y327Y|SEC14L1_uc010wti.1_Silent_p.Y293Y	NM_003003	NP_002994	Q92503	S14L1_HUMAN	SEC14 (S. cerevisiae)-like 1 isoform a	327	CRAL-TRIO.				transport	Golgi apparatus|integral to membrane	binding			ovary(2)	2																		---	---	---	---
TNRC6C	57690	broad.mit.edu	37	17	76073380	76073380	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:76073380G>A	uc002jud.2	+	10	3775	c.3175G>A	c.(3175-3177)GGG>AGG	p.G1059R	TNRC6C_uc002juf.2_Missense_Mutation_p.G1056R|TNRC6C_uc002jue.2_Missense_Mutation_p.G1056R	NM_018996	NP_061869	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C isoform 2	1059					gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)															---	---	---	---
Unknown	0	broad.mit.edu	37	17	76525771	76525771	+	IGR	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:76525771G>A								DNAH17 (56915 upstream) : CYTH1 (144360 downstream)																																			---	---	---	---
USP36	57602	broad.mit.edu	37	17	76816009	76816009	+	Intron	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:76816009T>C	uc002jvz.1	-						USP36_uc002jwa.1_Intron|USP36_uc002jwc.1_Intron	NM_025090	NP_079366			ubiquitin specific peptidase 36						ubiquitin-dependent protein catabolic process	nucleolus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)|breast(1)|kidney(1)	5			BRCA - Breast invasive adenocarcinoma(99;0.000842)|OV - Ovarian serous cystadenocarcinoma(97;0.151)															---	---	---	---
CCDC40	55036	broad.mit.edu	37	17	78022497	78022497	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:78022497C>A	uc010dht.2	+	5	819	c.792C>A	c.(790-792)TCC>TCA	p.S264S	CCDC40_uc010wub.1_Silent_p.S264S|CCDC40_uc002jxm.3_Silent_p.S47S	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	264					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)															---	---	---	---
RNF213	57674	broad.mit.edu	37	17	78341838	78341838	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:78341838G>A	uc002jyh.1	+	19	6492	c.6269G>A	c.(6268-6270)TGC>TAC	p.C2090Y	uc002jyi.1_Intron|RNF213_uc010dhw.1_Missense_Mutation_p.C472Y	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)															---	---	---	---
AZI1	22994	broad.mit.edu	37	17	79171622	79171622	+	Missense_Mutation	SNP	C	T	T	rs144147050		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:79171622C>T	uc002jzp.1	-	13	1746	c.1546G>A	c.(1546-1548)GAA>AAA	p.E516K	AZI1_uc002jzm.1_5'Flank|AZI1_uc002jzn.1_Missense_Mutation_p.E513K|AZI1_uc002jzo.1_Missense_Mutation_p.E513K|AZI1_uc010wum.1_Missense_Mutation_p.E516K	NM_014984	NP_055799	Q9UPN4	AZI1_HUMAN	5-azacytidine induced 1 isoform a	516					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centrosome|cytosol|intracellular membrane-bounded organelle				central_nervous_system(2)|large_intestine(1)|ovary(1)	4	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)															---	---	---	---
RAB40B	10966	broad.mit.edu	37	17	80617530	80617530	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:80617530C>T	uc002kft.2	-	4	394	c.268G>A	c.(268-270)GTG>ATG	p.V90M	RAB40B_uc002kfs.2_RNA	NM_006822	NP_006813	Q12829	RB40B_HUMAN	RAB40B, member RAS oncogene family	90					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			central_nervous_system(1)	1	Breast(20;0.00132)|all_neural(118;0.0952)	all_cancers(8;0.072)|all_epithelial(8;0.139)	BRCA - Breast invasive adenocarcinoma(99;0.0262)|OV - Ovarian serous cystadenocarcinoma(97;0.061)															---	---	---	---
FN3KRP	79672	broad.mit.edu	37	17	80684826	80684826	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:80684826T>C	uc002kfu.2	+	6	759	c.709T>C	c.(709-711)TCT>CCT	p.S237P	FN3KRP_uc010wvr.1_Missense_Mutation_p.S187P	NM_024619	NP_078895	Q9HA64	KT3K_HUMAN	fructosamine 3 kinase related protein	237							kinase activity				0	Breast(20;0.000523)|all_neural(118;0.0952)		BRCA - Breast invasive adenocarcinoma(99;0.0344)|OV - Ovarian serous cystadenocarcinoma(97;0.061)															---	---	---	---
TBCD	6904	broad.mit.edu	37	17	80861316	80861316	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:80861316A>G	uc002kfz.2	+	19	1896	c.1766A>G	c.(1765-1767)AAC>AGC	p.N589S	TBCD_uc002kfx.1_Missense_Mutation_p.N572S|TBCD_uc002kfy.1_Missense_Mutation_p.N589S|TBCD_uc002kgb.1_5'UTR	NM_005993	NP_005984	Q9BTW9	TBCD_HUMAN	beta-tubulin cofactor D	589	HEAT 2.				'de novo' posttranslational protein folding|adherens junction assembly|negative regulation of cell-substrate adhesion|negative regulation of microtubule polymerization|post-chaperonin tubulin folding pathway|tight junction assembly	adherens junction|cytoplasm|lateral plasma membrane|microtubule|tight junction	beta-tubulin binding|chaperone binding|GTPase activator activity				0	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0266)|all_epithelial(8;0.0696)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.18)															---	---	---	---
KIAA0802	23255	broad.mit.edu	37	18	8824732	8824732	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:8824732G>A	uc002knr.2	+	15	3366	c.3224G>A	c.(3223-3225)CGT>CAT	p.R1075H	KIAA0802_uc002knq.2_Missense_Mutation_p.R1034H|KIAA0802_uc002kns.2_Missense_Mutation_p.R415H	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	1385											0																		---	---	---	---
PPP4R1	9989	broad.mit.edu	37	18	9559564	9559564	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:9559564A>G	uc002koe.1	-	14	1999	c.1881T>C	c.(1879-1881)TCT>TCC	p.S627S	PPP4R1_uc002kof.2_Silent_p.S44S|PPP4R1_uc010wzo.1_Silent_p.S473S|PPP4R1_uc002kod.1_Silent_p.S610S|PPP4R1_uc010wzp.1_RNA	NM_001042388	NP_001035847	Q8TF05	PP4R1_HUMAN	protein phosphatase 4, regulatory subunit 1	627					protein phosphorylation|signal transduction	protein phosphatase 4 complex	protein binding|protein phosphatase type 4 regulator activity			skin(1)	1																		---	---	---	---
ROCK1	6093	broad.mit.edu	37	18	18624112	18624112	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:18624112G>T	uc002kte.2	-	6	1567	c.626C>A	c.(625-627)TCT>TAT	p.S209Y		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein	209	Protein kinase.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)																	---	---	---	---
RBBP8	5932	broad.mit.edu	37	18	20596890	20596890	+	Intron	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:20596890A>G	uc002ktw.2	+						RBBP8_uc002kty.2_Intron|RBBP8_uc002ktz.2_Intron|RBBP8_uc002kua.2_Intron|RBBP8_uc010xap.1_Intron	NM_002894	NP_002885			retinoblastoma binding protein 8 isoform a						cell cycle checkpoint|DNA double-strand break processing involved in repair via single-strand annealing|meiosis|regulation of transcription from RNA polymerase II promoter	nucleus	damaged DNA binding|protein binding|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)|lung(1)|skin(1)	3	all_cancers(21;4.34e-05)|all_epithelial(16;8.3e-07)|Lung NSC(20;0.0107)|Colorectal(14;0.0202)|all_lung(20;0.0291)|Ovarian(20;0.19)		OV - Ovarian serous cystadenocarcinoma(1;0.00196)										Direct_reversal_of_damage|Homologous_recombination					---	---	---	---
LAMA3	3909	broad.mit.edu	37	18	21399906	21399906	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:21399906C>A	uc002kuq.2	+	19	2335	c.2249C>A	c.(2248-2250)CCG>CAG	p.P750Q	LAMA3_uc002kur.2_Missense_Mutation_p.P750Q	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	750					cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
LAMA3	3909	broad.mit.edu	37	18	21494380	21494380	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:21494380C>A	uc002kuq.2	+	57	7422	c.7336C>A	c.(7336-7338)CGG>AGG	p.R2446R	LAMA3_uc002kur.2_Silent_p.R2390R|LAMA3_uc002kus.3_Silent_p.R837R|LAMA3_uc002kut.3_Silent_p.R781R	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	2446	Laminin G-like 1.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
LAMA3	3909	broad.mit.edu	37	18	21496554	21496554	+	Silent	SNP	G	T	T	rs139567388	byFrequency;by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:21496554G>T	uc002kuq.2	+	60	7904	c.7818G>T	c.(7816-7818)ACG>ACT	p.T2606T	LAMA3_uc002kur.2_Silent_p.T2550T|LAMA3_uc002kus.3_Silent_p.T997T|LAMA3_uc002kut.3_Silent_p.T941T	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	2606	Laminin G-like 2.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
OSBPL1A	114876	broad.mit.edu	37	18	21912999	21912999	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:21912999T>C	uc002kve.2	-	7	706	c.532A>G	c.(532-534)ACA>GCA	p.T178A		NM_080597	NP_542164	Q9BXW6	OSBL1_HUMAN	oxysterol-binding protein-like 1A isoform B	178	ANK 3.				cholesterol metabolic process|lipid transport|vesicle-mediated transport		phospholipid binding			ovary(4)	4	all_cancers(21;0.000396)|all_epithelial(16;4.36e-06)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0505)|Ovarian(20;0.17)																	---	---	---	---
ZNF521	25925	broad.mit.edu	37	18	22806757	22806757	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:22806757C>T	uc002kvk.2	-	4	1372	c.1125G>A	c.(1123-1125)CCG>CCA	p.P375P	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Silent_p.P375P|ZNF521_uc002kvl.2_Silent_p.P155P	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	375					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)							T	PAX5	ALL								---	---	---	---
PSMA8	143471	broad.mit.edu	37	18	23758861	23758861	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:23758861C>T	uc002kvq.2	+	5	677	c.563C>T	c.(562-564)GCC>GTC	p.A188V	PSMA8_uc002kvo.2_Missense_Mutation_p.A144V|PSMA8_uc002kvp.2_Missense_Mutation_p.A182V|PSMA8_uc002kvr.2_Missense_Mutation_p.A156V	NM_144662	NP_653263	Q8TAA3	PSA7L_HUMAN	proteasome alpha 8 subunit isoform 1	188					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	threonine-type endopeptidase activity			skin(1)	1	all_cancers(21;0.000585)|Lung NSC(5;0.00148)|all_lung(6;0.0038)|Ovarian(20;0.124)		OV - Ovarian serous cystadenocarcinoma(3;0.000324)|all cancers(3;0.000954)|LUSC - Lung squamous cell carcinoma(2;0.181)															---	---	---	---
TTR	7276	broad.mit.edu	37	18	29171922	29171922	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:29171922G>T	uc002kwx.3	+	1	193	c.57G>T	c.(55-57)GAG>GAT	p.E19D		NM_000371	NP_000362	P02766	TTHY_HUMAN	transthyretin precursor	19					transport	cytoplasm	hormone activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(10;0.00523)		Diclofenac(DB00586)|Diethylstilbestrol(DB00255)|Diflunisal(DB00861)|Dimethyl sulfoxide(DB01093)|Levothyroxine(DB00451)|Liothyronine(DB00279)													---	---	---	---
B4GALT6	9331	broad.mit.edu	37	18	29264301	29264301	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:29264301T>C	uc002kwz.3	-	1	386	c.89A>G	c.(88-90)TAC>TGC	p.Y30C	B4GALT6_uc010dma.2_Missense_Mutation_p.Y30C|B4GALT6_uc010dmb.2_Missense_Mutation_p.Y30C	NM_004775	NP_004766	Q9UBX8	B4GT6_HUMAN	beta-1,4-galactosyltransferase 6	30	Helical; Signal-anchor for type II membrane protein; (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	metal ion binding				0			OV - Ovarian serous cystadenocarcinoma(10;0.00791)															---	---	---	---
KLHL14	57565	broad.mit.edu	37	18	30350456	30350456	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:30350456G>A	uc002kxm.1	-	2	487	c.99C>T	c.(97-99)TGC>TGT	p.C33C		NM_020805	NP_065856	Q9P2G3	KLH14_HUMAN	kelch-like 14	33	BTB.					cytosol|endoplasmic reticulum membrane				ovary(1)	1																		---	---	---	---
NOL4	8715	broad.mit.edu	37	18	31538193	31538193	+	Intron	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:31538193C>T	uc010dmi.2	-						NOL4_uc010xbs.1_Intron|NOL4_uc002kxr.3_Intron|NOL4_uc010xbt.1_Intron|NOL4_uc010dmh.2_Intron|NOL4_uc010xbu.1_Intron|NOL4_uc002kxt.3_Intron|NOL4_uc010xbv.1_Intron	NM_003787	NP_003778			nucleolar protein 4							nucleolus	RNA binding			ovary(3)	3																		---	---	---	---
MOCOS	55034	broad.mit.edu	37	18	33795823	33795823	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:33795823C>T	uc002kzq.3	+	8	1703	c.1680C>T	c.(1678-1680)GTC>GTT	p.V560V		NM_017947	NP_060417	Q96EN8	MOCOS_HUMAN	molybdenum cofactor sulfurase	560					Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	lyase activity|Mo-molybdopterin cofactor sulfurase activity|molybdenum ion binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)													---	---	---	---
MOCOS	55034	broad.mit.edu	37	18	33831236	33831236	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:33831236A>G	uc002kzq.3	+	11	2177	c.2154A>G	c.(2152-2154)AAA>AAG	p.K718K		NM_017947	NP_060417	Q96EN8	MOCOS_HUMAN	molybdenum cofactor sulfurase	718	MOSC.				Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	lyase activity|Mo-molybdopterin cofactor sulfurase activity|molybdenum ion binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)													---	---	---	---
CELF4	56853	broad.mit.edu	37	18	34853109	34853109	+	Silent	SNP	C	T	T	rs145932686		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:34853109C>T	uc002lae.2	-	7	1215	c.819G>A	c.(817-819)GCG>GCA	p.A273A	CELF4_uc010dnd.1_Silent_p.A271A|CELF4_uc002lag.2_Silent_p.A263A|CELF4_uc002laf.2_Silent_p.A268A|CELF4_uc002lai.2_Silent_p.A258A|CELF4_uc002lah.1_5'UTR|CELF4_uc002laj.1_Missense_Mutation_p.G109S	NM_020180	NP_064565	Q9BZC1	CELF4_HUMAN	bruno-like 4, RNA binding protein isoform 1	273	Sufficient for RNA-binding and MSE- dependent splicing activity.|Ala-rich.				embryo development|germ cell development|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	BRE binding|nucleotide binding|translation repressor activity, nucleic acid binding			ovary(2)	2																		---	---	---	---
CELF4	56853	broad.mit.edu	37	18	35145576	35145576	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:35145576T>C	uc002lae.2	-	1	425	c.29A>G	c.(28-30)AAC>AGC	p.N10S	CELF4_uc010dnd.1_Missense_Mutation_p.N10S|CELF4_uc002lag.2_Missense_Mutation_p.N10S|CELF4_uc002laf.2_Missense_Mutation_p.N6S|CELF4_uc002lai.2_Missense_Mutation_p.N6S	NM_020180	NP_064565	Q9BZC1	CELF4_HUMAN	bruno-like 4, RNA binding protein isoform 1	10	Sufficient for RNA-binding and MSE- dependent splicing activity.				embryo development|germ cell development|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	BRE binding|nucleotide binding|translation repressor activity, nucleic acid binding			ovary(2)	2																		---	---	---	---
SLC14A2	8170	broad.mit.edu	37	18	43262375	43262375	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:43262375C>A	uc010dnj.2	+	21	2975	c.2654C>A	c.(2653-2655)CCG>CAG	p.P885Q	SLC14A2_uc002lbe.2_Missense_Mutation_p.P885Q	NM_007163	NP_009094	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter),	885						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity	p.P885P(1)		upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|skin(1)	4																		---	---	---	---
TCEB3B	51224	broad.mit.edu	37	18	44560392	44560392	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:44560392T>C	uc002lcr.1	-	1	1597	c.1244A>G	c.(1243-1245)AAC>AGC	p.N415S	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	415					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4																		---	---	---	---
KIAA0427	9811	broad.mit.edu	37	18	46385824	46385824	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:46385824G>A	uc002ldc.2	+	12	1976	c.1691G>A	c.(1690-1692)CGG>CAG	p.R564Q	KIAA0427_uc002ldd.2_Missense_Mutation_p.R566Q|KIAA0427_uc002lde.3_Missense_Mutation_p.R193Q	NM_014772	NP_055587	O43310	CTIF_HUMAN	hypothetical protein LOC9811 isoform 1	564	MIF4G.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational initiation	perinuclear region of cytoplasm	protein binding	p.R564Q(1)			0																		---	---	---	---
LIPG	9388	broad.mit.edu	37	18	47110076	47110076	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:47110076A>G	uc002ldv.2	+	8	1560	c.1308A>G	c.(1306-1308)CAA>CAG	p.Q436Q	LIPG_uc010xdh.1_Silent_p.Q362Q	NM_006033	NP_006024	Q9Y5X9	LIPE_HUMAN	endothelial lipase precursor	436	PLAT.				cholesterol homeostasis|high-density lipoprotein particle remodeling|phospholipid catabolic process|phospholipid homeostasis|positive regulation of cholesterol transport|positive regulation of high-density lipoprotein particle clearance|reverse cholesterol transport	extracellular space	heparin binding|lipoprotein lipase activity|phospholipase A1 activity|protein binding|triglyceride lipase activity			ovary(1)|skin(1)	2																		---	---	---	---
MBD1	4152	broad.mit.edu	37	18	47803030	47803030	+	Splice_Site	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:47803030A>G	uc010dow.1	-	5	912	c.475_splice	c.e5+1	p.A159_splice	MBD1_uc002lef.2_Splice_Site|MBD1_uc002leg.2_Splice_Site_p.A159_splice|MBD1_uc010xdi.1_Splice_Site_p.A185_splice|MBD1_uc002leh.3_Splice_Site_p.A159_splice|MBD1_uc002len.2_Splice_Site_p.A159_splice|MBD1_uc002lei.3_Splice_Site_p.A159_splice|MBD1_uc002lej.3_Splice_Site_p.A159_splice|MBD1_uc002lek.3_Splice_Site_p.A159_splice|MBD1_uc002lel.3_Splice_Site_p.A159_splice|MBD1_uc002lem.3_Splice_Site_p.A159_splice|MBD1_uc010xdj.1_Splice_Site_p.A159_splice|MBD1_uc010xdk.1_Splice_Site_p.A159_splice|MBD1_uc010dox.1_Splice_Site_p.A159_splice|MBD1_uc002leo.2_Splice_Site_p.A159_splice	NM_015846	NP_056671			methyl-CpG binding domain protein 1 isoform 1						negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|nuclear speck	methyl-CpG binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
MALT1	10892	broad.mit.edu	37	18	56409250	56409250	+	Intron	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:56409250C>T	uc002lhm.1	+						MALT1_uc002lhn.1_Intron	NM_006785	NP_006776			mucosa associated lymphoid tissue lymphoma						activation of NF-kappaB-inducing kinase activity|anti-apoptosis|nuclear export|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of T cell cytokine production|protein oligomerization|proteolysis|T cell receptor signaling pathway	CBM complex|cytosol|nucleus|perinuclear region of cytoplasm	cysteine-type endopeptidase activity|protein self-association|signal transducer activity|ubiquitin-protein ligase activity			ovary(2)|lung(1)|central_nervous_system(1)	4								T	BIRC3	MALT								---	---	---	---
LMAN1	3998	broad.mit.edu	37	18	57020469	57020469	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:57020469G>A	uc002lhz.2	-	5	636	c.604C>T	c.(604-606)CGA>TGA	p.R202*	LMAN1_uc010xek.1_Nonsense_Mutation_p.R202*	NM_005570	NP_005561	P49257	LMAN1_HUMAN	lectin, mannose-binding, 1 precursor	202	Lumenal (Potential).|L-type lectin-like.				blood coagulation|ER to Golgi vesicle-mediated transport|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	mannose binding|metal ion binding|unfolded protein binding			skin(1)	1		Colorectal(73;0.0946)			Antihemophilic Factor(DB00025)													---	---	---	---
TNFRSF11A	8792	broad.mit.edu	37	18	60035961	60035961	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:60035961A>G	uc002lin.2	+	9	849	c.811A>G	c.(811-813)ACA>GCA	p.T271A	TNFRSF11A_uc010dpv.2_Intron	NM_003839	NP_003830	Q9Y6Q6	TNR11_HUMAN	tumor necrosis factor receptor superfamily,	271	Cytoplasmic (Potential).				adaptive immune response|cell-cell signaling|circadian temperature homeostasis|monocyte chemotaxis|osteoclast differentiation|positive regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|response to interleukin-1|response to lipopolysaccharide	external side of plasma membrane|integral to membrane	metal ion binding|tumor necrosis factor receptor activity			breast(2)|lung(1)	3		Colorectal(73;0.188)												Paget_Disease_of_Bone				---	---	---	---
VPS4B	9525	broad.mit.edu	37	18	61067280	61067280	+	Splice_Site	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:61067280C>T	uc002lix.2	-	7	1050	c.790_splice	c.e7+1	p.G264_splice	VPS4B_uc010dpx.2_Splice_Site_p.G264_splice|VPS4B_uc010dpy.2_Splice_Site_p.G146_splice|VPS4B_uc010dpz.1_Splice_Site_p.G146_splice	NM_004869	NP_004860			vacuolar protein sorting factor 4B						cell cycle|cell division|cellular membrane organization|endosome to lysosome transport via multivesicular body sorting pathway|intracellular cholesterol transport|protein transport|response to lipid	cytosol|early endosome|late endosome membrane|lysosome|nucleus|vacuolar membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding			ovary(1)	1																		---	---	---	---
CDH7	1005	broad.mit.edu	37	18	63529940	63529940	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:63529940C>T	uc002ljz.2	+	11	1976	c.1651C>T	c.(1651-1653)CGG>TGG	p.R551W	CDH7_uc002lka.2_Missense_Mutation_p.R551W|CDH7_uc002lkb.2_Missense_Mutation_p.R551W	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	551	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)																---	---	---	---
DSEL	92126	broad.mit.edu	37	18	65179963	65179963	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:65179963C>A	uc002lke.1	-	2	3137	c.1913G>T	c.(1912-1914)TGG>TTG	p.W638L		NM_032160	NP_115536	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	628						integral to membrane	isomerase activity|sulfotransferase activity			ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	6		Esophageal squamous(42;0.129)																---	---	---	---
CCDC102B	79839	broad.mit.edu	37	18	66678242	66678242	+	Silent	SNP	T	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:66678242T>A	uc002lkk.2	+	9	1558	c.1335T>A	c.(1333-1335)ACT>ACA	p.T445T	CCDC102B_uc002lki.2_Silent_p.T445T	NM_001093729	NP_001087198	Q68D86	C102B_HUMAN	coiled-coil domain containing 102B	445	Potential.									ovary(1)|lung(1)|skin(1)	3		Esophageal squamous(42;0.0559)|Colorectal(73;0.0604)																---	---	---	---
RTTN	25914	broad.mit.edu	37	18	67755348	67755348	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:67755348C>T	uc002lkp.2	-	31	4247	c.4179G>A	c.(4177-4179)CTG>CTA	p.L1393L	RTTN_uc002lko.2_RNA|RTTN_uc010xfb.1_Silent_p.L481L	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	1393							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)																---	---	---	---
ATP9B	374868	broad.mit.edu	37	18	76903868	76903868	+	Intron	SNP	A	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:76903868A>T	uc002lmx.2	+						ATP9B_uc002lmv.1_Intron|ATP9B_uc002lmw.1_Intron|ATP9B_uc002lmy.1_Intron|ATP9B_uc002lmz.1_Intron	NM_198531	NP_940933			ATPase, class II, type 9B						ATP biosynthetic process	integral to membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)	3		Esophageal squamous(42;0.018)|Melanoma(33;0.0964)|Prostate(75;0.171)		OV - Ovarian serous cystadenocarcinoma(15;1.44e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0405)														---	---	---	---
CTDP1	9150	broad.mit.edu	37	18	77470424	77470424	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:77470424C>T	uc002lnh.1	+	6	998	c.851C>T	c.(850-852)ACG>ATG	p.T284M	CTDP1_uc002lni.1_Missense_Mutation_p.T284M|CTDP1_uc010drd.1_Missense_Mutation_p.T284M	NM_004715	NP_004706	Q9Y5B0	CTDP1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II,	284	FCP1 homology.				positive regulation of viral transcription|protein dephosphorylation|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	CTD phosphatase activity|DNA-directed RNA polymerase activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;5.2e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0277)														---	---	---	---
PRSSL1	400668	broad.mit.edu	37	19	691849	691849	+	Intron	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:691849G>A	uc002lpl.1	-						PRSSL1_uc010xfs.1_Intron	NM_214710	NP_999875			protease, serine-like 1 precursor						proteolysis	extracellular region	serine-type endopeptidase activity				0		all_epithelial(18;2.19e-21)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
C19orf21	126353	broad.mit.edu	37	19	757730	757730	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:757730C>T	uc002lpo.2	+	2	867	c.784C>T	c.(784-786)CGT>TGT	p.R262C		NM_173481	NP_775752	Q8IVT2	CS021_HUMAN	hypothetical protein LOC126353	262										upper_aerodigestive_tract(1)	1		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000145)|all_lung(49;0.000236)|Breast(49;0.0014)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
ELANE	1991	broad.mit.edu	37	19	856072	856072	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:856072T>C	uc002lqb.2	+	5	750	c.712T>C	c.(712-714)TTT>CTT	p.F238L		NM_001972	NP_001963	P08246	ELNE_HUMAN	neutrophil elastase preproprotein	238	Peptidase S1.				cellular calcium ion homeostasis|negative regulation of chemokine biosynthetic process|negative regulation of chemotaxis|negative regulation of inflammatory response|negative regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of MAP kinase activity|positive regulation of smooth muscle cell proliferation|protein catabolic process|proteolysis|response to UV	cell surface|extracellular region|stored secretory granule	bacterial cell surface binding|cytokine binding|heparin binding			pancreas(1)	1					Alpha-1-proteinase inhibitor(DB00058)|Filgrastim(DB00099)|Pegfilgrastim(DB00019)									Kostmann_syndrome				---	---	---	---
MED16	10025	broad.mit.edu	37	19	889762	889762	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:889762C>T	uc002lqd.1	-	4	474	c.323G>A	c.(322-324)TGG>TAG	p.W108*	MED16_uc002lqe.2_Nonsense_Mutation_p.W97*|MED16_uc002lqf.2_Nonsense_Mutation_p.W97*|MED16_uc010xfv.1_Intron|MED16_uc010xfw.1_Nonsense_Mutation_p.W97*|MED16_uc010xfx.1_Nonsense_Mutation_p.W97*|MED16_uc010xfy.1_Nonsense_Mutation_p.W97*	NM_005481	NP_005472	Q9Y2X0	MED16_HUMAN	mediator complex subunit 16	108	WD 1.				androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
REXO1	57455	broad.mit.edu	37	19	1828587	1828587	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:1828587G>A	uc002lua.3	-	2	296	c.201C>T	c.(199-201)CCC>CCT	p.P67P	REXO1_uc010dsr.1_Silent_p.P21P	NM_020695	NP_065746	Q8N1G1	REXO1_HUMAN	transcription elongation factor B polypeptide 3	67						nucleus	exonuclease activity|nucleic acid binding				0		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
KLF16	83855	broad.mit.edu	37	19	1854753	1854753	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:1854753C>T	uc002luc.2	-	2	532	c.464G>A	c.(463-465)CGC>CAC	p.R155H	KLF16_uc010xgt.1_RNA	NM_031918	NP_114124	Q9BXK1	KLF16_HUMAN	BTE-binding protein 4	155						nucleus	DNA binding|zinc ion binding				0		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
SCAMP4	113178	broad.mit.edu	37	19	1917829	1917829	+	Intron	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:1917829C>T	uc002luj.2	+						SCAMP4_uc002lui.1_Intron|SCAMP4_uc002luk.2_Intron|SCAMP4_uc010dss.2_Intron	NM_079834	NP_524558			secretory carrier membrane protein 4						protein transport	integral to membrane					0		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
DOT1L	84444	broad.mit.edu	37	19	2210737	2210737	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:2210737G>A	uc002lvb.3	+	14	1270	c.1234G>A	c.(1234-1236)GGG>AGG	p.G412R	DOT1L_uc002lvc.1_5'Flank	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	412	Required for interaction with nucleosomes and DNA.					nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
AMH	268	broad.mit.edu	37	19	2249524	2249524	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:2249524G>A	uc002lvh.2	+	1	412	c.193G>A	c.(193-195)GGC>AGC	p.G65S	hsa-mir-4321|MI0015852_5'Flank	NM_000479	NP_000470	P03971	MIS_HUMAN	anti-Mullerian hormone precursor	65					cell differentiation|cell-cell signaling|gonadal mesoderm development|Mullerian duct regression|positive regulation of gene expression|sex determination	extracellular space	growth factor activity|hormone activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)										Persistant_Mullerian_Duct_Syndrome_(type_I_and_II)				---	---	---	---
TBXA2R	6915	broad.mit.edu	37	19	3600213	3600213	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:3600213G>A	uc002lyg.1	-	2	634	c.420C>T	c.(418-420)CGC>CGT	p.R140R	TBXA2R_uc002lye.1_Intron	NM_001060	NP_001051	P21731	TA2R_HUMAN	thromboxane A2 receptor isoform alpha	140	Cytoplasmic (Potential).				platelet activation	integral to plasma membrane	guanyl-nucleotide exchange factor activity|protein binding|thromboxane A2 receptor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)	Ridogrel(DB01207)													---	---	---	---
TBXA2R	6915	broad.mit.edu	37	19	3600354	3600354	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:3600354G>A	uc002lyg.1	-	2	493	c.279C>T	c.(277-279)TTC>TTT	p.F93F	TBXA2R_uc002lye.1_Silent_p.F93F	NM_001060	NP_001051	P21731	TA2R_HUMAN	thromboxane A2 receptor isoform alpha	93	Extracellular (Potential).				platelet activation	integral to plasma membrane	guanyl-nucleotide exchange factor activity|protein binding|thromboxane A2 receptor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)	Ridogrel(DB01207)													---	---	---	---
TBXA2R	6915	broad.mit.edu	37	19	3600562	3600562	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:3600562A>G	uc002lyg.1	-	2	285	c.71T>C	c.(70-72)CTG>CCG	p.L24P	TBXA2R_uc002lye.1_Missense_Mutation_p.L24P	NM_001060	NP_001051	P21731	TA2R_HUMAN	thromboxane A2 receptor isoform alpha	24	Extracellular (Potential).				platelet activation	integral to plasma membrane	guanyl-nucleotide exchange factor activity|protein binding|thromboxane A2 receptor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)	Ridogrel(DB01207)													---	---	---	---
PIP5K1C	23396	broad.mit.edu	37	19	3633494	3633494	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:3633494A>G	uc002lyj.1	-	17	2002	c.1945T>C	c.(1945-1947)TAC>CAC	p.Y649H	PIP5K1C_uc010xhq.1_Intron	NM_012398	NP_036530	O60331	PI51C_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	649	Mediates interaction with TLN2.				axon guidance	cytosol|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding			stomach(2)|skin(2)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.95e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0026)|STAD - Stomach adenocarcinoma(1328;0.183)														---	---	---	---
PIP5K1C	23396	broad.mit.edu	37	19	3638999	3638999	+	Silent	SNP	C	T	T	rs146725634		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:3638999C>T	uc002lyj.1	-	16	1860	c.1803G>A	c.(1801-1803)CCG>CCA	p.P601P	PIP5K1C_uc010xhq.1_Silent_p.P601P|PIP5K1C_uc010xhr.1_Silent_p.P601P	NM_012398	NP_036530	O60331	PI51C_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	601					axon guidance	cytosol|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding			stomach(2)|skin(2)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.95e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0026)|STAD - Stomach adenocarcinoma(1328;0.183)														---	---	---	---
EEF2	1938	broad.mit.edu	37	19	3977575	3977575	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:3977575G>A	uc002lze.2	-	13	2184	c.2101C>T	c.(2101-2103)CGC>TGC	p.R701C		NM_001961	NP_001952	P13639	EF2_HUMAN	eukaryotic translation elongation factor 2	701						cytosol|ribonucleoprotein complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|GBM - Glioblastoma multiforme(1328;0.0223)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
ZBTB7A	51341	broad.mit.edu	37	19	4054930	4054930	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4054930T>C	uc002lzh.2	-	2	376	c.301A>G	c.(301-303)ACA>GCA	p.T101A	ZBTB7A_uc002lzi.2_Missense_Mutation_p.T101A	NM_015898	NP_056982	O95365	ZBT7A_HUMAN	zinc finger and BTB domain containing 7A	101	BTB.				cell differentiation|multicellular organismal development|transcription, DNA-dependent	nucleus	DNA binding|histone acetyltransferase binding|zinc ion binding			pancreas(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.014)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
FSD1	79187	broad.mit.edu	37	19	4318416	4318416	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4318416C>T	uc002lzy.2	+	9	1026	c.873C>T	c.(871-873)GAC>GAT	p.D291D	FSD1_uc002lzz.2_Silent_p.D291D|FSD1_uc002maa.2_Silent_p.D104D	NM_024333	NP_077309	Q9BTV5	FSD1_HUMAN	fibronectin type III and SPRY domain containing	291	B30.2/SPRY.				cell division|mitosis	cleavage furrow|microtubule|microtubule organizing center|nucleus				skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.034)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
SH3GL1	6455	broad.mit.edu	37	19	4366969	4366969	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4366969C>A	uc002maj.2	-	2	174	c.68G>T	c.(67-69)GGG>GTG	p.G23V	SH3GL1_uc002mak.2_Missense_Mutation_p.G23V|SH3GL1_uc010xig.1_Missense_Mutation_p.G23V	NM_003025	NP_003016	Q99961	SH3G1_HUMAN	SH3-domain GRB2-like 1	23	BAR.				central nervous system development|endocytosis|signal transduction	early endosome membrane	lipid binding|protein binding			ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0152)|STAD - Stomach adenocarcinoma(1328;0.182)				T	MLL	AL								---	---	---	---
PLIN3	10226	broad.mit.edu	37	19	4839535	4839535	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4839535C>A	uc002mbj.2	-	8	1151	c.974G>T	c.(973-975)CGG>CTG	p.R325L	PLIN3_uc002mbk.2_Missense_Mutation_p.R313L|PLIN3_uc002mbl.3_Missense_Mutation_p.R324L	NM_005817	NP_005808	O60664	PLIN3_HUMAN	mannose 6 phosphate receptor binding protein 1	325					vesicle-mediated transport	endosome membrane|Golgi apparatus|lipid particle	protein binding				0					Galsulfase(DB01279)|Idursulfase(DB01271)													---	---	---	---
PTPRS	5802	broad.mit.edu	37	19	5231328	5231328	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:5231328G>A	uc002mbv.2	-	14	2382	c.2148C>T	c.(2146-2148)GAC>GAT	p.D716D	PTPRS_uc002mbu.1_Intron|PTPRS_uc010xin.1_Intron|PTPRS_uc002mbw.2_Silent_p.D703D|PTPRS_uc002mbx.2_Intron|PTPRS_uc002mby.2_Intron	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	716	Extracellular (Potential).				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)														---	---	---	---
PTPRS	5802	broad.mit.edu	37	19	5258116	5258116	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:5258116A>G	uc002mbv.2	-	8	852	c.618T>C	c.(616-618)AGT>AGC	p.S206S	PTPRS_uc002mbu.1_Silent_p.S197S|PTPRS_uc010xin.1_Silent_p.S197S|PTPRS_uc002mbw.2_Silent_p.S197S|PTPRS_uc002mbx.2_Silent_p.S197S|PTPRS_uc002mby.2_Silent_p.S197S	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	206	Extracellular (Potential).|Ig-like C2-type 2.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)														---	---	---	---
DUS3L	56931	broad.mit.edu	37	19	5785423	5785423	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:5785423G>A	uc002mdc.2	-	12	1948	c.1851C>T	c.(1849-1851)AGC>AGT	p.S617S	PRR22_uc002mdb.1_5'Flank|PRR22_uc010xiv.1_5'Flank|DUS3L_uc002mdd.2_Silent_p.S375S|DUS3L_uc010duk.2_Silent_p.S282S	NM_020175	NP_064560	Q96G46	DUS3L_HUMAN	dihydrouridine synthase 3-like isoform 1	617					tRNA processing		flavin adenine dinucleotide binding|nucleic acid binding|tRNA dihydrouridine synthase activity|zinc ion binding				0																		---	---	---	---
RANBP3	8498	broad.mit.edu	37	19	5918577	5918577	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:5918577G>A	uc002mdw.2	-	15	1630	c.1403C>T	c.(1402-1404)GCC>GTC	p.A468V	RANBP3_uc002mdv.2_Missense_Mutation_p.A187V|RANBP3_uc002mdx.2_Missense_Mutation_p.A463V|RANBP3_uc002mdy.2_Missense_Mutation_p.A400V|RANBP3_uc002mdz.2_Missense_Mutation_p.A395V|RANBP3_uc010duq.2_Missense_Mutation_p.A373V|RANBP3_uc002mea.2_Missense_Mutation_p.A335V|RANBP3_uc010xix.1_Missense_Mutation_p.A340V	NM_007322	NP_015561	Q9H6Z4	RANB3_HUMAN	RAN binding protein 3 isoform RANBP3-d	468	RanBD1.				intracellular transport|protein transport	cytoplasm|nucleus	Ran GTPase binding			breast(1)	1																		---	---	---	---
RFX2	5990	broad.mit.edu	37	19	6002856	6002856	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6002856T>C	uc002meb.2	-	14	1795	c.1526A>G	c.(1525-1527)CAG>CGG	p.Q509R	RFX2_uc002mec.2_Missense_Mutation_p.Q484R	NM_000635	NP_000626	P48378	RFX2_HUMAN	regulatory factor X2 isoform a	509					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(4)|ovary(1)|skin(1)	6																		---	---	---	---
VAV1	7409	broad.mit.edu	37	19	6833932	6833932	+	Missense_Mutation	SNP	G	A	A	rs140267055		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6833932G>A	uc002mfu.1	+	19	1842	c.1745G>A	c.(1744-1746)CGC>CAC	p.R582H	VAV1_uc010xjh.1_Missense_Mutation_p.R550H|VAV1_uc010dva.1_Missense_Mutation_p.R582H|VAV1_uc002mfv.1_Missense_Mutation_p.R527H	NM_005428	NP_005419	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	582					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(4)|ovary(4)|breast(3)|central_nervous_system(2)|kidney(2)|skin(1)	16																		---	---	---	---
ARHGEF18	23370	broad.mit.edu	37	19	7518514	7518514	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:7518514C>T	uc002mgi.2	+	7	1706	c.1453C>T	c.(1453-1455)CTC>TTC	p.L485F	ARHGEF18_uc010xjm.1_Missense_Mutation_p.L327F|ARHGEF18_uc002mgh.2_Missense_Mutation_p.L327F|ARHGEF18_uc002mgj.1_Missense_Mutation_p.L128F	NM_001130955	NP_001124427	Q6ZSZ5	ARHGI_HUMAN	Rho/Rac guanine nucleotide exchange factor 18	485					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell shape|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1		Renal(5;0.0902)																---	---	---	---
KIAA1543	57662	broad.mit.edu	37	19	7670306	7670306	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:7670306C>T	uc002mgv.3	+	2	444	c.343C>T	c.(343-345)CCT>TCT	p.P115S	KIAA1543_uc002mgu.3_Missense_Mutation_p.P115S	NM_020902	NP_065953	Q9P1Y5	CAMP3_HUMAN	NEZHA isoform 2	115					epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			pancreas(1)	1																		---	---	---	---
KIAA1543	57662	broad.mit.edu	37	19	7675616	7675616	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:7675616T>C	uc002mgv.3	+	7	1032	c.931T>C	c.(931-933)TTC>CTC	p.F311L	KIAA1543_uc002mgu.3_Missense_Mutation_p.F338L	NM_020902	NP_065953	Q9P1Y5	CAMP3_HUMAN	NEZHA isoform 2	311	CH.				epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			pancreas(1)	1																		---	---	---	---
EVI5L	115704	broad.mit.edu	37	19	7913812	7913812	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:7913812G>A	uc002min.2	+	4	487	c.333G>A	c.(331-333)CTG>CTA	p.L111L	EVI5L_uc010xjz.1_Silent_p.L111L|EVI5L_uc002mio.1_5'Flank	NM_145245	NP_660288	Q96CN4	EVI5L_HUMAN	ecotropic viral integration site 5-like isoform	111						intracellular	protein binding|Rab GTPase activator activity			ovary(1)	1																		---	---	---	---
MAP2K7	5609	broad.mit.edu	37	19	7975205	7975205	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:7975205G>A	uc002mit.2	+	4	459	c.394G>A	c.(394-396)GGC>AGC	p.G132S	MAP2K7_uc002miv.2_Missense_Mutation_p.G132S|MAP2K7_uc010xka.1_RNA|MAP2K7_uc010xkb.1_Missense_Mutation_p.G132S|MAP2K7_uc010dvv.2_Missense_Mutation_p.G7S	NM_145185	NP_660186	O14733	MP2K7_HUMAN	mitogen-activated protein kinase kinase 7	132	Protein kinase.|ATP (By similarity).				activation of JUN kinase activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleus	ATP binding|JUN kinase kinase activity|magnesium ion binding|protein binding|protein kinase binding|protein phosphatase binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			large_intestine(7)|central_nervous_system(2)|ovary(1)|lung(1)	11					Etoposide(DB00773)													---	---	---	---
MAP2K7	5609	broad.mit.edu	37	19	7976447	7976447	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:7976447T>C	uc002mit.2	+	9	1128	c.1063T>C	c.(1063-1065)TCC>CCC	p.S355P	MAP2K7_uc002miv.2_Missense_Mutation_p.S362P|MAP2K7_uc010xka.1_RNA|MAP2K7_uc010xkb.1_Missense_Mutation_p.S362P|MAP2K7_uc010dvv.2_Missense_Mutation_p.S230P	NM_145185	NP_660186	O14733	MP2K7_HUMAN	mitogen-activated protein kinase kinase 7	355	Protein kinase.				activation of JUN kinase activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleus	ATP binding|JUN kinase kinase activity|magnesium ion binding|protein binding|protein kinase binding|protein phosphatase binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			large_intestine(7)|central_nervous_system(2)|ovary(1)|lung(1)	11					Etoposide(DB00773)													---	---	---	---
FBN3	84467	broad.mit.edu	37	19	8201281	8201281	+	Missense_Mutation	SNP	C	T	T	rs139750989		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:8201281C>T	uc002mjf.2	-	10	1357	c.1336G>A	c.(1336-1338)GAG>AAG	p.E446K		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	446	EGF-like 3.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11																		---	---	---	---
HNRNPM	4670	broad.mit.edu	37	19	8536286	8536286	+	Silent	SNP	C	T	T	rs17179758		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:8536286C>T	uc010dwe.2	+	10	1052	c.972C>T	c.(970-972)ATC>ATT	p.I324I	HNRNPM_uc010dwc.1_Silent_p.I324I|HNRNPM_uc010xke.1_Silent_p.I285I|HNRNPM_uc010dwd.2_Silent_p.I285I|HNRNPM_uc002mka.2_Silent_p.I204I	NM_005968	NP_005959	P52272	HNRPM_HUMAN	heterogeneous nuclear ribonucleoprotein M	324					alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|integral to plasma membrane|nuclear matrix|nucleolus|paraspeckles	nucleotide binding|protein domain specific binding|RNA binding				0																		---	---	---	---
MUC16	94025	broad.mit.edu	37	19	9012462	9012462	+	Intron	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9012462T>C	uc002mkp.2	-						MUC16_uc010xki.1_Intron	NM_024690	NP_078966			mucin 16						cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57																		---	---	---	---
MUC16	94025	broad.mit.edu	37	19	9066715	9066715	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9066715T>C	uc002mkp.2	-	3	20935	c.20731A>G	c.(20731-20733)ACC>GCC	p.T6911A		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6913	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57																		---	---	---	---
MUC16	94025	broad.mit.edu	37	19	9077648	9077648	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9077648G>T	uc002mkp.2	-	3	10002	c.9798C>A	c.(9796-9798)ACC>ACA	p.T3266T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3267	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57																		---	---	---	---
MUC16	94025	broad.mit.edu	37	19	9087145	9087145	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9087145G>A	uc002mkp.2	-	1	4874	c.4670C>T	c.(4669-4671)ACC>ATC	p.T1557I		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1557	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57																		---	---	---	---
OR7G2	390882	broad.mit.edu	37	19	9213067	9213067	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9213067C>T	uc010xkk.1	-	1	916	c.916G>A	c.(916-918)GTG>ATG	p.V306M		NM_001005193	NP_001005193	Q8NG99	OR7G2_HUMAN	olfactory receptor, family 7, subfamily G,	285	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1																		---	---	---	---
OR7G2	390882	broad.mit.edu	37	19	9213738	9213738	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9213738A>G	uc010xkk.1	-	1	245	c.245T>C	c.(244-246)TTC>TCC	p.F82S		NM_001005193	NP_001005193	Q8NG99	OR7G2_HUMAN	olfactory receptor, family 7, subfamily G,	61	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1																		---	---	---	---
RDH8	50700	broad.mit.edu	37	19	10132068	10132068	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10132068G>T	uc002mmr.2	+	5	923	c.674G>T	c.(673-675)AGG>ATG	p.R225M		NM_015725	NP_056540	Q9NYR8	RDH8_HUMAN	retinol dehydrogenase 8 (all-trans)	225					estrogen biosynthetic process|response to stimulus|visual perception	cytoplasm|integral to plasma membrane	binding|estradiol 17-beta-dehydrogenase activity|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity			ovary(3)|pancreas(1)	4			Epithelial(33;4.24e-05)		Vitamin A(DB00162)													---	---	---	---
C3P1	388503	broad.mit.edu	37	19	10160712	10160712	+	RNA	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10160712C>T	uc010dwx.1	+	12		c.1618C>T				NR_027300				Synthetic construct DNA, clone: pF1KB7402, Homo sapiens LOC388503 gene, without stop codon, in Flexi system.												0																		---	---	---	---
TYK2	7297	broad.mit.edu	37	19	10475594	10475594	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10475594C>A	uc002moc.3	-	8	1520	c.1142G>T	c.(1141-1143)CGG>CTG	p.R381L	TYK2_uc010dxe.2_Missense_Mutation_p.R196L|TYK2_uc002mod.2_Missense_Mutation_p.R381L	NM_003331	NP_003322	P29597	TYK2_HUMAN	tyrosine kinase 2	381	FERM.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|large_intestine(2)|ovary(1)|breast(1)	9			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)															---	---	---	---
PDE4A	5141	broad.mit.edu	37	19	10568615	10568615	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10568615C>T	uc002moj.2	+	8	1046	c.938C>T	c.(937-939)GCG>GTG	p.A313V	PDE4A_uc002mok.2_Missense_Mutation_p.A287V|PDE4A_uc002mol.2_Missense_Mutation_p.A252V|PDE4A_uc002mom.2_Missense_Mutation_p.A74V|PDE4A_uc002mon.2_Intron|PDE4A_uc002moo.2_5'Flank	NM_001111307	NP_001104777	P27815	PDE4A_HUMAN	phosphodiesterase 4A isoform 1	313					signal transduction	cytosol|membrane fraction|perinuclear region of cytoplasm|ruffle membrane|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(20;5.8e-10)|Epithelial(33;7.58e-07)|all cancers(31;3.91e-06)		Cilostazol(DB01166)|Dipyridamole(DB00975)|Dyphylline(DB00651)|Enprofylline(DB00824)|Iloprost(DB01088)|Milrinone(DB00235)|Pentoxifylline(DB00806)|Phentolamine(DB00692)|Tadalafil(DB00820)|Theophylline(DB00277)													---	---	---	---
SLC44A2	57153	broad.mit.edu	37	19	10746171	10746171	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10746171G>A	uc002mpf.2	+	14	1352	c.1213G>A	c.(1213-1215)GCG>ACG	p.A405T	SLC44A2_uc002mpe.3_Missense_Mutation_p.A403T|SLC44A2_uc002mpg.1_Missense_Mutation_p.A125T|SLC44A2_uc002mph.2_5'Flank	NM_020428	NP_065161	Q8IWA5	CTL2_HUMAN	solute carrier family 44, member 2 isoform 1	405	Extracellular (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			ovary(1)	1			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)													---	---	---	---
TMED1	11018	broad.mit.edu	37	19	10943855	10943855	+	Missense_Mutation	SNP	C	T	T	rs151223408	byFrequency	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10943855C>T	uc002mpy.2	-	4	616	c.500G>A	c.(499-501)CGC>CAC	p.R167H	DNM2_uc002mpx.1_3'UTR	NM_006858	NP_006849	Q13445	TMED1_HUMAN	interleukin 1 receptor-like 1 ligand precursor	167	Extracellular (Potential).				cell-cell signaling|signal transduction|transport	integral to membrane|plasma membrane	receptor binding			ovary(2)|breast(1)|central_nervous_system(1)	4																		---	---	---	---
C19orf52	90580	broad.mit.edu	37	19	11040108	11040108	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:11040108C>T	uc002mqd.1	+	2	588	c.513C>T	c.(511-513)CGC>CGT	p.R171R	YIPF2_uc002mqb.2_5'Flank|YIPF2_uc002mqc.2_5'Flank	NM_138358	NP_612367	Q9BSF4	CS052_HUMAN	hypothetical protein LOC90580	171											0																		---	---	---	---
RAB3D	9545	broad.mit.edu	37	19	11446376	11446376	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:11446376G>A	uc002mqy.2	-	3	550	c.312C>T	c.(310-312)ATC>ATT	p.I104I		NM_004283	NP_004274	O95716	RAB3D_HUMAN	RAB3D, member RAS oncogene family	104					exocytosis|protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			ovary(2)	2																		---	---	---	---
CCDC151	115948	broad.mit.edu	37	19	11537809	11537809	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:11537809C>T	uc002mrs.2	-	4	639	c.496G>A	c.(496-498)GCC>ACC	p.A166T	CCDC151_uc002mrr.2_Missense_Mutation_p.A101T|CCDC151_uc010dxz.2_Missense_Mutation_p.A140T	NM_145045	NP_659482	A5D8V7	CC151_HUMAN	coiled-coil domain containing 151	166	Potential.									ovary(1)	1																		---	---	---	---
CNN1	1264	broad.mit.edu	37	19	11658614	11658614	+	Silent	SNP	G	A	A	rs3826802	by1000genomes	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:11658614G>A	uc002msc.1	+	5	557	c.393G>A	c.(391-393)GCG>GCA	p.A131A	CNN1_uc010xmb.1_Silent_p.A81A|CNN1_uc010xmc.1_Silent_p.A81A	NM_001299	NP_001290	P51911	CNN1_HUMAN	calponin 1, basic, smooth muscle	131	CH.				actomyosin structure organization|regulation of smooth muscle contraction	cytoskeleton	actin binding|calmodulin binding				0																		---	---	---	---
ZNF44	51710	broad.mit.edu	37	19	12383962	12383962	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:12383962A>G	uc010xmj.1	-	5	1457	c.1252T>C	c.(1252-1254)TGT>CGT	p.C418R	ZNF44_uc002mtl.2_Intron|ZNF44_uc010dyr.1_Intron|ZNF44_uc010xmi.1_RNA|ZNF44_uc002mtn.3_RNA|ZNF44_uc010dys.2_Missense_Mutation_p.C370R	NM_001164276	NP_001157748	P15621	ZNF44_HUMAN	zinc finger protein 44 isoform 1	418	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1		Renal(1328;0.157)		GBM - Glioblastoma multiforme(1328;0.0164)|Lung(535;0.179)														---	---	---	---
ZNF799	90576	broad.mit.edu	37	19	12503015	12503015	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:12503015C>T	uc010dyt.2	-	4	347	c.197G>A	c.(196-198)CGT>CAT	p.R66H	ZNF799_uc002mts.3_Intron	NM_001080821	NP_001074290	Q96GE5	ZN799_HUMAN	zinc finger protein 799	66	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|ovary(2)|skin(1)	6																		---	---	---	---
ZNF709	163051	broad.mit.edu	37	19	12575943	12575943	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:12575943G>T	uc002mtv.3	-	4	954	c.793C>A	c.(793-795)CAA>AAA	p.Q265K	ZNF709_uc002mtw.3_Missense_Mutation_p.Q233K|ZNF709_uc002mtx.3_Missense_Mutation_p.Q265K	NM_152601	NP_689814	Q8N972	ZN709_HUMAN	zinc finger protein 709 isoform a	265	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
WDR83	84292	broad.mit.edu	37	19	12781366	12781366	+	Intron	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:12781366A>G	uc002mue.3	+						WDR83_uc002muc.2_Intron|C19orf56_uc002mud.2_5'Flank|WDR83_uc010dyw.2_Intron	NM_001099737	NP_001093207			mitogen-activated protein kinase organizer 1						nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|cytoplasm				lung(1)|breast(1)	2																		---	---	---	---
NACC1	112939	broad.mit.edu	37	19	13249039	13249039	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:13249039G>A	uc002mwm.2	+	6	1571	c.1403G>A	c.(1402-1404)CGC>CAC	p.R468H		NM_052876	NP_443108	Q96RE7	NACC1_HUMAN	transcriptional repressor NAC1	468	BEN.				negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|protein homooligomerization|transcription, DNA-dependent	cytoplasm|nuclear body					0																		---	---	---	---
CACNA1A	773	broad.mit.edu	37	19	13346469	13346469	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:13346469T>C	uc010dze.2	-	32	5265	c.5029A>G	c.(5029-5031)ACC>GCC	p.T1677A	CACNA1A_uc010xnd.1_Missense_Mutation_p.T382A|CACNA1A_uc002mwx.3_Missense_Mutation_p.T382A|CACNA1A_uc010dzc.2_Missense_Mutation_p.T1202A|CACNA1A_uc002mwy.3_Missense_Mutation_p.T1676A|CACNA1A_uc002mwv.3_Missense_Mutation_p.T193A	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	1677	IV.|Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)											OREG0025293	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
CACNA1A	773	broad.mit.edu	37	19	13368176	13368176	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:13368176C>A	uc010dze.2	-	28	4817	c.4581G>T	c.(4579-4581)CTG>CTT	p.L1527L	CACNA1A_uc010xnd.1_Silent_p.L232L|CACNA1A_uc002mwx.3_Silent_p.L232L|CACNA1A_uc010dzc.2_Silent_p.L1052L|CACNA1A_uc002mwy.3_Silent_p.L1526L|CACNA1A_uc010xne.1_Silent_p.L1055L|CACNA1A_uc002mwv.3_Silent_p.L43L	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	1527	Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)													---	---	---	---
CC2D1A	54862	broad.mit.edu	37	19	14029367	14029367	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:14029367C>A	uc002mxo.2	+	8	1223	c.924C>A	c.(922-924)CTC>CTA	p.L308L	CC2D1A_uc002mxn.2_Silent_p.L207L|CC2D1A_uc002mxp.2_Silent_p.L308L|CC2D1A_uc010dzh.2_5'UTR|CC2D1A_uc002mxq.1_5'UTR	NM_017721	NP_060191	Q6P1N0	C2D1A_HUMAN	coiled-coil and C2 domain containing 1A	308	Pro-rich.				positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity				0			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)															---	---	---	---
CC2D1A	54862	broad.mit.edu	37	19	14034390	14034390	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:14034390C>T	uc002mxo.2	+	16	2093	c.1794C>T	c.(1792-1794)ACC>ACT	p.T598T	CC2D1A_uc002mxp.2_Silent_p.T598T|CC2D1A_uc010dzh.2_Silent_p.T167T|CC2D1A_uc002mxq.1_Silent_p.T243T	NM_017721	NP_060191	Q6P1N0	C2D1A_HUMAN	coiled-coil and C2 domain containing 1A	598					positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity				0			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)															---	---	---	---
PKN1	5585	broad.mit.edu	37	19	14582559	14582559	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:14582559C>T	uc002myp.2	+	22	2960	c.2792C>T	c.(2791-2793)GCC>GTC	p.A931V	PKN1_uc002myq.2_Missense_Mutation_p.A937V|PKN1_uc002myr.2_Missense_Mutation_p.A271V	NM_002741	NP_002732	Q16512	PKN1_HUMAN	protein kinase N1 isoform 2	931	AGC-kinase C-terminal.				activation of JUN kinase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	endosome|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|GTP-Rho binding|histone binding|histone deacetylase binding|histone kinase activity (H3-T11 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|Rac GTPase binding			ovary(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)	8																		---	---	---	---
GIPC1	10755	broad.mit.edu	37	19	14593766	14593766	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:14593766C>T	uc002myt.2	-	4	293	c.23G>A	c.(22-24)CGG>CAG	p.R8Q	GIPC1_uc002myu.2_Missense_Mutation_p.R8Q|GIPC1_uc002myv.2_Intron|GIPC1_uc002myw.2_Intron|GIPC1_uc002myx.2_Missense_Mutation_p.R8Q|GIPC1_uc002myy.2_Intron	NM_005716	NP_005707	O14908	GIPC1_HUMAN	regulator of G-protein signalling 19 interacting	8					endothelial cell migration|G-protein coupled receptor protein signaling pathway|glutamate secretion|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|protein targeting|regulation of protein stability|regulation of synaptic plasticity|synaptic transmission	cell cortex|dendritic shaft|dendritic spine|membrane fraction|soluble fraction|synaptic vesicle|vesicle membrane	actin binding|myosin binding|protein homodimerization activity|receptor binding				0																		---	---	---	---
EMR3	84658	broad.mit.edu	37	19	14772873	14772873	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:14772873T>C	uc002mzi.3	-	4	405	c.257A>G	c.(256-258)TAC>TGC	p.Y86C	EMR3_uc010dzp.2_Intron|EMR3_uc010xnv.1_Intron	NM_032571	NP_115960	Q9BY15	EMR3_HUMAN	egf-like module-containing mucin-like receptor	86	Extracellular (Potential).|EGF-like 2; calcium-binding (Potential).				neuropeptide signaling pathway	extracellular space|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(5)|skin(1)	6																		---	---	---	---
NOTCH3	4854	broad.mit.edu	37	19	15281319	15281319	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:15281319A>C	uc002nan.2	-	27	5013	c.4937T>G	c.(4936-4938)CTG>CGG	p.L1646R		NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	1646	Helical; (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)															---	---	---	---
CYP4F22	126410	broad.mit.edu	37	19	15648443	15648443	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:15648443G>T	uc002nbh.3	+	6	686	c.519G>T	c.(517-519)AAG>AAT	p.K173N		NM_173483	NP_775754	Q6NT55	CP4FN_HUMAN	cytochrome P450, family 4, subfamily F,	173						endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			ovary(1)|pancreas(1)	2																		---	---	---	---
CYP4F2	8529	broad.mit.edu	37	19	16000362	16000362	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:16000362C>T	uc002nbs.1	-	7	839	c.789G>A	c.(787-789)GTG>GTA	p.V263V	CYP4F2_uc010xot.1_Silent_p.V114V|CYP4F2_uc010xou.1_Silent_p.V114V	NM_001082	NP_001073	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F,	263					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			ovary(1)|skin(1)	2																		---	---	---	---
OR10H4	126541	broad.mit.edu	37	19	16060359	16060359	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:16060359A>G	uc010xov.1	+	1	542	c.542A>G	c.(541-543)CAT>CGT	p.H181R		NM_001004465	NP_001004465	Q8NGA5	O10H4_HUMAN	olfactory receptor, family 10, subfamily H,	181	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2																		---	---	---	---
CPAMD8	27151	broad.mit.edu	37	19	17091299	17091299	+	Intron	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17091299C>T	uc002nfb.2	-							NM_015692	NP_056507			C3 and PZP-like, alpha-2-macroglobulin domain							extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13																		---	---	---	---
FAM129C	199786	broad.mit.edu	37	19	17648228	17648228	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17648228T>C	uc010xpr.1	+	6	702	c.564T>C	c.(562-564)CCT>CCC	p.P188P	FAM129C_uc010xpq.1_Silent_p.P188P|FAM129C_uc010xps.1_Silent_p.P157P|FAM129C_uc010xpt.1_RNA|FAM129C_uc002ngy.3_5'Flank|FAM129C_uc010xpu.1_5'Flank|FAM129C_uc002ngz.3_5'Flank|FAM129C_uc010eaw.2_5'Flank|FAM129C_uc002nhb.2_5'Flank	NM_173544	NP_775815	Q86XR2	NIBL2_HUMAN	B-cell novel protein 1 isoform a	188											0																		---	---	---	---
MAP1S	55201	broad.mit.edu	37	19	17831751	17831751	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17831751G>T	uc002nhe.1	+	2	134	c.125G>T	c.(124-126)CGG>CTG	p.R42L	MAP1S_uc010eaz.1_Intron|MAP1S_uc010eba.1_Missense_Mutation_p.R42L|MAP1S_uc002nhf.1_Intron|MAP1S_uc010xpv.1_Missense_Mutation_p.R16L	NM_018174	NP_060644	Q66K74	MAP1S_HUMAN	BPY2 interacting protein 1	42	Necessary for the microtubule-organizing center localization.				apoptosis|brain development|microtubule bundle formation|mitochondrion transport along microtubule|neuron projection morphogenesis	cytosol|dendrite|microtubule|neuronal cell body|nucleus|perinuclear region of cytoplasm|spindle|synapse	actin filament binding|beta-tubulin binding|DNA binding|microtubule binding			central_nervous_system(1)	1																		---	---	---	---
TMEM161A	54929	broad.mit.edu	37	19	19232368	19232368	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19232368C>T	uc002nlg.2	-	8	796	c.766G>A	c.(766-768)GCA>ACA	p.A256T	TMEM161A_uc010eca.2_RNA|TMEM161A_uc002nlh.2_Missense_Mutation_p.A231T|TMEM161A_uc002nli.2_Missense_Mutation_p.A153T|TMEM161A_uc002nlj.2_Missense_Mutation_p.A131T	NM_017814	NP_060284	Q9NX61	T161A_HUMAN	transmembrane protein 161A precursor	256	Extracellular (Potential).				cellular response to oxidative stress|cellular response to UV|negative regulation of apoptosis|positive regulation of DNA repair|response to retinoic acid	integral to membrane				breast(2)	2			OV - Ovarian serous cystadenocarcinoma(5;1.19e-05)|Epithelial(12;0.0011)															---	---	---	---
ZNF682	91120	broad.mit.edu	37	19	20133814	20133814	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:20133814T>C	uc002noq.2	-	3	348	c.225A>G	c.(223-225)CCA>CCG	p.P75P	ZNF682_uc002noo.2_Silent_p.P43P|ZNF682_uc002nop.2_Silent_p.P43P|ZNF682_uc010eck.2_Intron	NM_033196	NP_149973	O95780	ZN682_HUMAN	zinc finger protein 682 isoform 1	75	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2																		---	---	---	---
ZNF430	80264	broad.mit.edu	37	19	21240210	21240210	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:21240210A>G	uc002npj.2	+	5	1206	c.1096A>G	c.(1096-1098)ATT>GTT	p.I366V	ZNF430_uc002npk.2_Missense_Mutation_p.I365V	NM_025189	NP_079465	Q9H8G1	ZN430_HUMAN	zinc finger protein 430	366	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2																		---	---	---	---
UQCRFS1	7386	broad.mit.edu	37	19	29698962	29698962	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:29698962G>A	uc002nsd.2	-	2	429	c.318C>T	c.(316-318)AGC>AGT	p.S106S		NM_006003	NP_005994	P47985	UCRI_HUMAN	ubiquinol-cytochrome c reductase, Rieske	106					respiratory electron transport chain	integral to membrane|mitochondrial respiratory chain complex III	2 iron, 2 sulfur cluster binding|metal ion binding|ubiquinol-cytochrome-c reductase activity				0	Breast(6;0.0545)|Esophageal squamous(110;0.239)		Lung(7;0.092)															---	---	---	---
ZNF536	9745	broad.mit.edu	37	19	30935815	30935815	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:30935815C>A	uc002nsu.1	+	2	1484	c.1346C>A	c.(1345-1347)CCC>CAC	p.P449H	ZNF536_uc010edd.1_Missense_Mutation_p.P449H	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	449					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)																	---	---	---	---
ZNF536	9745	broad.mit.edu	37	19	31039827	31039827	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:31039827G>A	uc002nsu.1	+	4	3439	c.3301G>A	c.(3301-3303)GAC>AAC	p.D1101N	ZNF536_uc010edd.1_Missense_Mutation_p.D1101N	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1101					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)																	---	---	---	---
ANKRD27	84079	broad.mit.edu	37	19	33134328	33134328	+	Intron	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:33134328C>A	uc002ntn.1	-						ANKRD27_uc002nto.1_Intron	NM_032139	NP_115515			ankyrin repeat domain 27 (VPS9 domain)						early endosome to late endosome transport	early endosome|lysosome	GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|skin(2)|pancreas(1)	5	Esophageal squamous(110;0.137)																	---	---	---	---
RGS9BP	388531	broad.mit.edu	37	19	33167385	33167385	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:33167385C>T	uc002ntp.1	+	1	1073	c.216C>T	c.(214-216)CGC>CGT	p.R72R	ANKRD27_uc002ntn.1_5'Flank|ANKRD27_uc002nto.1_5'Flank	NM_207391	NP_997274	Q6ZS82	R9BP_HUMAN	RGS9 anchor protein	72	Cytoplasmic (Potential).				negative regulation of signal transduction	integral to membrane				central_nervous_system(1)	1	Esophageal squamous(110;0.137)																	---	---	---	---
WDR88	126248	broad.mit.edu	37	19	33638559	33638559	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:33638559C>T	uc002nui.2	+	4	563	c.485C>T	c.(484-486)GCC>GTC	p.A162V		NM_173479	NP_775750	Q6ZMY6	WDR88_HUMAN	PQQ repeat and WD repeat domain containing	162	WD 2.									ovary(1)|breast(1)|central_nervous_system(1)	3	Esophageal squamous(110;0.137)																	---	---	---	---
SCN1B	6324	broad.mit.edu	37	19	35523445	35523445	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:35523445C>T	uc002nxp.2	+	2	245	c.54C>T	c.(52-54)TGC>TGT	p.C18C	SCN1B_uc002nxo.1_Silent_p.C18C|SCN1B_uc010xsg.1_Silent_p.C18C	NM_001037	NP_001028	Q07699	SCN1B_HUMAN	sodium channel, voltage-gated, type I, beta	18					axon guidance|synaptic transmission	integral to membrane	voltage-gated sodium channel activity			ovary(1)|central_nervous_system(1)	2	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)															---	---	---	---
FAM187B	148109	broad.mit.edu	37	19	35719446	35719446	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:35719446G>T	uc002nyk.1	-	1	183	c.138C>A	c.(136-138)TCC>TCA	p.S46S		NM_152481	NP_689694	Q17R55	F187B_HUMAN	family with sequence similarity 187, member B	46	Extracellular (Potential).					integral to membrane				ovary(2)	2																		---	---	---	---
GAPDHS	26330	broad.mit.edu	37	19	36034357	36034357	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36034357C>T	uc002oaf.1	+	8	973	c.857C>T	c.(856-858)GCG>GTG	p.A286V	uc010eec.1_RNA|uc002oag.2_Intron|TMEM147_uc002oai.1_5'Flank|TMEM147_uc002oaj.1_5'Flank|TMEM147_uc002oak.1_5'Flank	NM_014364	NP_055179	O14556	G3PT_HUMAN	glyceraldehyde-3-phosphate dehydrogenase,	286					gluconeogenesis|glycolysis|positive regulation of glycolysis|sperm motility	cytosol	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity|NAD binding|protein binding				0	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		NADH(DB00157)													---	---	---	---
KIRREL2	84063	broad.mit.edu	37	19	36351855	36351855	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36351855G>A	uc002ocb.3	+	8	1185	c.973G>A	c.(973-975)GTG>ATG	p.V325M	KIRREL2_uc002obz.3_Missense_Mutation_p.V325M|KIRREL2_uc002oca.3_Missense_Mutation_p.V275M|KIRREL2_uc002occ.3_Missense_Mutation_p.V272M|KIRREL2_uc002ocd.3_Missense_Mutation_p.V322M	NM_199180	NP_954649	Q6UWL6	KIRR2_HUMAN	kin of IRRE-like 2 isoform c	325	Extracellular (Potential).|Ig-like C2-type 4.				cell adhesion	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)															---	---	---	---
THAP8	199745	broad.mit.edu	37	19	36530862	36530862	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36530862C>A	uc002oda.1	-	2	805	c.260G>T	c.(259-261)CGG>CTG	p.R87L	uc002ocy.2_Intron|THAP8_uc010xtb.1_Missense_Mutation_p.R44L|THAP8_uc010xtc.1_Intron	NM_152658	NP_689871	Q8NA92	THAP8_HUMAN	THAP domain containing 8	87							DNA binding|metal ion binding				0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)															---	---	---	---
ZNF382	84911	broad.mit.edu	37	19	37117125	37117125	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:37117125T>G	uc002oek.2	+	5	439	c.326T>G	c.(325-327)CTA>CGA	p.L109R	ZNF382_uc010efa.2_Missense_Mutation_p.L60R|ZNF382_uc010efb.2_Missense_Mutation_p.L108R|ZNF382_uc002oel.2_Missense_Mutation_p.L108R	NM_032825	NP_116214	Q96SR6	ZN382_HUMAN	zinc finger protein 382	109	Represses transcription (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)															---	---	---	---
ZNF585B	92285	broad.mit.edu	37	19	37697974	37697974	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:37697974G>T	uc002ofq.2	-	2	294	c.40C>A	c.(40-42)CTG>ATG	p.L14M	ZNF585B_uc002ofr.1_Translation_Start_Site	NM_152279	NP_689492	Q52M93	Z585B_HUMAN	zinc finger protein 585B	14					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)															---	---	---	---
ZNF571	51276	broad.mit.edu	37	19	38056225	38056225	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:38056225C>A	uc002ogt.2	-	4	1206	c.1105G>T	c.(1105-1107)GGG>TGG	p.G369W	uc002ogm.2_Intron|uc002ogn.2_Intron|ZNF540_uc002ogo.2_Intron|ZNF540_uc002ogp.2_Intron|ZNF540_uc002ogq.2_Intron|ZNF571_uc002ogr.1_Intron|uc002ogs.1_5'Flank|ZNF571_uc010efp.2_Missense_Mutation_p.G369W	NM_016536	NP_057620	Q7Z3V5	ZN571_HUMAN	zinc finger protein 571	369	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)															---	---	---	---
SIPA1L3	23094	broad.mit.edu	37	19	38643562	38643562	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:38643562G>A	uc002ohk.2	+	13	4125	c.3616G>A	c.(3616-3618)GGC>AGC	p.G1206S		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	1206					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)															---	---	---	---
RYR1	6261	broad.mit.edu	37	19	38990588	38990588	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:38990588G>T	uc002oit.2	+	45	7385	c.7255G>T	c.(7255-7257)GGA>TGA	p.G2419*	RYR1_uc002oiu.2_Nonsense_Mutation_p.G2419*|RYR1_uc002oiv.1_5'UTR	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	2419	Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)													---	---	---	---
ACTN4	81	broad.mit.edu	37	19	39214987	39214987	+	Intron	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:39214987G>A	uc002oja.1	+						ACTN4_uc002ojb.1_5'Flank	NM_004924	NP_004915			actinin, alpha 4						platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity				0	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)															---	---	---	---
CAPN12	147968	broad.mit.edu	37	19	39228150	39228150	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:39228150C>T	uc002ojd.1	-	9	1403	c.1094G>A	c.(1093-1095)CGT>CAT	p.R365H	CAPN12_uc010egd.1_5'Flank|CAPN12_uc002ojc.1_5'Flank	NM_144691	NP_653292	Q6ZSI9	CAN12_HUMAN	calpain 12	365	Domain III.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			central_nervous_system(1)|pancreas(1)	2	all_cancers(60;2.87e-05)|Ovarian(47;0.0454)		Lung(45;0.00416)|LUSC - Lung squamous cell carcinoma(53;0.00741)															---	---	---	---
IL28B	282617	broad.mit.edu	37	19	39734729	39734729	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:39734729A>G	uc010xut.1	-	3	331	c.327T>C	c.(325-327)GCT>GCC	p.A109A	IL28B_uc010xuu.1_Silent_p.A109A	NM_172139	NP_742151	Q8IZI9	IL28B_HUMAN	interleukin 28B	109					response to virus	extracellular space	cytokine activity				0	all_cancers(60;2.81e-07)|all_lung(34;7.81e-08)|Lung NSC(34;9.29e-08)|all_epithelial(25;3.9e-07)|Ovarian(47;0.0315)		Epithelial(26;1.55e-27)|all cancers(26;1.41e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)															---	---	---	---
FCGBP	8857	broad.mit.edu	37	19	40362848	40362848	+	Silent	SNP	G	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:40362848G>C	uc002omp.3	-	32	15230	c.15222C>G	c.(15220-15222)CGC>CGG	p.R5074R		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	5074						extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)															---	---	---	---
FCGBP	8857	broad.mit.edu	37	19	40424239	40424239	+	Missense_Mutation	SNP	T	G	G	rs144589100		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:40424239T>G	uc002omp.3	-	4	1972	c.1964A>C	c.(1963-1965)AAC>ACC	p.N655T		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	655	VWFD 1.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)															---	---	---	---
SPTBN4	57731	broad.mit.edu	37	19	41008168	41008168	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41008168T>C	uc002ony.2	+	9	1117	c.1031T>C	c.(1030-1032)GTG>GCG	p.V344A	SPTBN4_uc002onx.2_Missense_Mutation_p.V344A|SPTBN4_uc002onz.2_Missense_Mutation_p.V344A	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	344	Spectrin 1.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)															---	---	---	---
HNRNPUL1	11100	broad.mit.edu	37	19	41807512	41807512	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41807512A>G	uc002oqb.3	+	11	1879	c.1590A>G	c.(1588-1590)GTA>GTG	p.V530V	CYP2F1_uc010xvw.1_Intron|HNRNPUL1_uc002opz.3_Silent_p.V430V|HNRNPUL1_uc002oqa.3_Silent_p.V430V|HNRNPUL1_uc010ehm.2_Silent_p.V530V|HNRNPUL1_uc002oqc.3_Silent_p.V416V|HNRNPUL1_uc002oqe.3_Intron|HNRNPUL1_uc002oqd.3_Silent_p.V430V|HNRNPUL1_uc010ehn.2_Silent_p.V430V|HNRNPUL1_uc010eho.2_Silent_p.V430V|HNRNPUL1_uc010xvy.1_Silent_p.V430V|HNRNPUL1_uc010ehp.2_Silent_p.V386V|HNRNPUL1_uc002oqf.3_5'Flank	NM_007040	NP_008971	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	530	Necessary for interaction with TP53.|Necessary for interaction with BRD7 and transcriptional activation.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			central_nervous_system(1)|skin(1)	2																		---	---	---	---
HNRNPUL1	11100	broad.mit.edu	37	19	41807560	41807560	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41807560C>T	uc002oqb.3	+	11	1927	c.1638C>T	c.(1636-1638)ACC>ACT	p.T546T	CYP2F1_uc010xvw.1_Intron|HNRNPUL1_uc002opz.3_Silent_p.T446T|HNRNPUL1_uc002oqa.3_Silent_p.T446T|HNRNPUL1_uc010ehm.2_Silent_p.T546T|HNRNPUL1_uc002oqc.3_Silent_p.T432T|HNRNPUL1_uc002oqe.3_Intron|HNRNPUL1_uc002oqd.3_Silent_p.T446T|HNRNPUL1_uc010ehn.2_Silent_p.T446T|HNRNPUL1_uc010eho.2_Silent_p.T446T|HNRNPUL1_uc010xvy.1_Silent_p.T446T|HNRNPUL1_uc010ehp.2_Silent_p.T402T|HNRNPUL1_uc002oqf.3_5'Flank	NM_007040	NP_008971	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	546	Necessary for interaction with TP53.|Necessary for interaction with BRD7 and transcriptional activation.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			central_nervous_system(1)|skin(1)	2																		---	---	---	---
HNRNPUL1	11100	broad.mit.edu	37	19	41810111	41810111	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41810111C>A	uc002oqb.3	+	13	2496	c.2207C>A	c.(2206-2208)CCT>CAT	p.P736H	CYP2F1_uc010xvw.1_Intron|HNRNPUL1_uc002opz.3_Missense_Mutation_p.P636H|HNRNPUL1_uc002oqa.3_Missense_Mutation_p.P636H|HNRNPUL1_uc010ehm.2_Missense_Mutation_p.P736H|HNRNPUL1_uc002oqc.3_Missense_Mutation_p.P622H|HNRNPUL1_uc002oqe.3_Intron|HNRNPUL1_uc002oqd.3_Missense_Mutation_p.P636H|HNRNPUL1_uc010ehn.2_Missense_Mutation_p.P636H|HNRNPUL1_uc010eho.2_Missense_Mutation_p.P636H|HNRNPUL1_uc010xvy.1_Missense_Mutation_p.P636H|HNRNPUL1_uc010ehp.2_Missense_Mutation_p.P592H|HNRNPUL1_uc002oqf.3_Missense_Mutation_p.P260H	NM_007040	NP_008971	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	736	Pro-rich.|Necessary for interaction with TP53.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			central_nervous_system(1)|skin(1)	2																		---	---	---	---
ZNF526	116115	broad.mit.edu	37	19	42730321	42730321	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42730321G>A	uc002osz.1	+	3	1922	c.1766G>A	c.(1765-1767)CGA>CAA	p.R589Q		NM_133444	NP_597701	Q8TF50	ZN526_HUMAN	zinc finger protein 526	589	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0704)																---	---	---	---
LIPE	3991	broad.mit.edu	37	19	42910420	42910420	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42910420T>C	uc002otr.2	-	7	2535	c.2258A>G	c.(2257-2259)TAC>TGC	p.Y753C	uc010eif.1_Intron	NM_005357	NP_005348	Q05469	LIPS_HUMAN	hormone-sensitive lipase	753					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			ovary(1)|breast(1)	2		Prostate(69;0.00682)																---	---	---	---
PSG11	5680	broad.mit.edu	37	19	43519329	43519329	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:43519329G>A	uc002ovm.1	-	4	1010	c.903C>T	c.(901-903)TGC>TGT	p.C301C	PSG11_uc002ouw.2_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG11_uc002ovn.1_Silent_p.C307C|PSG11_uc002ovo.1_Silent_p.C179C|PSG11_uc002ovp.1_Silent_p.C179C	NM_002785	NP_002776	Q9UQ72	PSG11_HUMAN	pregnancy specific beta-1-glycoprotein 11	301	Ig-like C2-type 2.				female pregnancy	extracellular region					0		Prostate(69;0.00682)																---	---	---	---
CD177	57126	broad.mit.edu	37	19	43866242	43866242	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:43866242G>T	uc002owi.2	+	10	1126	c.1084G>T	c.(1084-1086)GGG>TGG	p.G362W	CD177_uc010eis.2_RNA|CD177_uc002owj.2_RNA	NM_020406	NP_065139	Q8N6Q3	CD177_HUMAN	CD177 molecule precursor	362	UPAR/Ly6 2.				blood coagulation|leukocyte migration	anchored to membrane|plasma membrane				central_nervous_system(1)	1		Prostate(69;0.00682)																---	---	---	---
XRCC1	7515	broad.mit.edu	37	19	44051120	44051120	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:44051120C>A	uc002owt.2	-	11	1329	c.1209G>T	c.(1207-1209)ATG>ATT	p.M403I	XRCC1_uc010xwp.1_Missense_Mutation_p.M372I	NM_006297	NP_006288	P18887	XRCC1_HUMAN	X-ray repair cross complementing protein 1	403	BRCT 1.				base-excision repair|single strand break repair	nucleoplasm	damaged DNA binding|protein binding	p.M403V(1)		ovary(2)|lung(2)|large_intestine(1)|prostate(1)|breast(1)	7		Prostate(69;0.0153)											Other_BER_factors					---	---	---	---
ZNF226	7769	broad.mit.edu	37	19	44681086	44681086	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:44681086A>G	uc002oyp.2	+	6	1815	c.1671A>G	c.(1669-1671)AAA>AAG	p.K557K	ZNF226_uc002oyq.2_Silent_p.K440K|ZNF226_uc002oyr.2_Silent_p.K440K|ZNF226_uc010ejg.2_3'UTR|ZNF226_uc002oys.2_Silent_p.K557K|ZNF226_uc002oyt.2_Silent_p.K557K	NM_001032373	NP_001027545	Q9NYT6	ZN226_HUMAN	zinc finger protein 226 isoform a	557					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)																---	---	---	---
CEACAM20	125931	broad.mit.edu	37	19	45017279	45017279	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:45017279G>A	uc010ejn.1	-	7	1395	c.1379C>T	c.(1378-1380)GCT>GTT	p.A460V	CEACAM20_uc010ejo.1_Missense_Mutation_p.A460V|CEACAM20_uc010ejp.1_Missense_Mutation_p.A367V|CEACAM20_uc010ejq.1_Missense_Mutation_p.A367V	NM_001102597	NP_001096067	Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion	460	Helical; (Potential).					integral to membrane				large_intestine(2)	2		Prostate(69;0.0352)														OREG0025538	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
BCAM	4059	broad.mit.edu	37	19	45315630	45315630	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:45315630G>A	uc002ozu.2	+	3	459	c.415G>A	c.(415-417)GCG>ACG	p.A139T	BCAM_uc002ozt.1_Missense_Mutation_p.A139T	NM_005581	NP_005572	P50895	BCAM_HUMAN	basal cell adhesion molecule isoform 1	139	Extracellular (Potential).|Ig-like V-type 1.				cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			skin(1)	1	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)																---	---	---	---
MARK4	57787	broad.mit.edu	37	19	45805630	45805630	+	Splice_Site	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:45805630A>G	uc002pbb.1	+	17	1928	c.1923_splice	c.e17-2	p.S641_splice	MARK4_uc002pba.1_Splice_Site_p.V668_splice					RecName: Full=MAP/microtubule affinity-regulating kinase 4;          EC=2.7.11.1; AltName: Full=MAP/microtubule affinity-regulating kinase-like 1;						microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			central_nervous_system(2)|large_intestine(1)	3		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)														---	---	---	---
ERCC2	2068	broad.mit.edu	37	19	45858119	45858119	+	Intron	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:45858119G>A	uc002pbj.2	-						ERCC2_uc002pbh.2_Intron|ERCC2_uc002pbi.2_Intron|ERCC2_uc010ejz.2_Intron|ERCC2_uc002pbk.2_Intron	NM_000400	NP_000391			excision repair cross-complementing rodent						cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)				Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				---	---	---	---
PPP1R13L	10848	broad.mit.edu	37	19	45901297	45901297	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:45901297G>A	uc002pbn.2	-	3	241	c.164C>T	c.(163-165)GCG>GTG	p.A55V	PPP1R13L_uc002pbo.2_Missense_Mutation_p.A55V|PPP1R13L_uc002pbp.2_Missense_Mutation_p.A55V	NM_006663	NP_006654	Q8WUF5	IASPP_HUMAN	protein phosphatase 1, regulatory subunit 13	55	Pro-rich.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	transcription corepressor activity|transcription factor binding			skin(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0182)														---	---	---	---
CD3EAP	10849	broad.mit.edu	37	19	45911523	45911523	+	Silent	SNP	G	A	A	rs140241488		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:45911523G>A	uc002pbq.1	+	3	785	c.297G>A	c.(295-297)ACG>ACA	p.T99T	PPP1R13L_uc002pbo.2_5'Flank|PPP1R13L_uc002pbp.2_5'Flank|CD3EAP_uc002pbr.1_Silent_p.T101T	NM_012099	NP_036231	O15446	RPA34_HUMAN	CD3E antigen, epsilon polypeptide associated	99					rRNA transcription|transmembrane receptor protein tyrosine kinase signaling pathway	chromosome|RNA polymerase I transcription factor complex	DNA-directed RNA polymerase activity			large_intestine(2)|ovary(2)	4		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0251)														---	---	---	---
NANOS2	339345	broad.mit.edu	37	19	46417728	46417728	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:46417728A>G	uc002pdu.2	-	1	309	c.224T>C	c.(223-225)GTC>GCC	p.V75A		NM_001029861	NP_001025032	P60321	NANO2_HUMAN	nanos homolog 2	75	Nanos-type.|C2HC 1.				germ-line stem cell maintenance|mRNA catabolic process|multicellular organismal development|negative regulation of meiosis|regulation of translation|spermatogenesis	cytoplasmic mRNA processing body|perinuclear region of cytoplasm	RNA binding|zinc ion binding				0		Ovarian(192;0.0308)|all_neural(266;0.0476)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0668)|Epithelial(262;0.231)														---	---	---	---
PGLYRP1	8993	broad.mit.edu	37	19	46526109	46526109	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:46526109C>A	uc002pdx.1	-	1	215	c.171G>T	c.(169-171)GTG>GTT	p.V57V		NM_005091	NP_005082	O75594	PGRP1_HUMAN	peptidoglycan recognition protein 1 precursor	57					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region	bacterial cell surface binding|N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(2)	2		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.0036)|GBM - Glioblastoma multiforme(486;0.022)|Epithelial(262;0.208)														---	---	---	---
PPP5C	5536	broad.mit.edu	37	19	46887138	46887138	+	Intron	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:46887138A>G	uc002pem.2	+						PPP5C_uc010xya.1_Intron|PPP5C_uc002pen.2_Intron|PPP5C_uc010xyb.1_Intron	NM_006247	NP_006238			protein phosphatase 5, catalytic subunit						mitosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein dephosphorylation|transcription, DNA-dependent	Golgi apparatus|nucleus	metal ion binding|protein binding|protein serine/threonine phosphatase activity|signal transducer activity			lung(1)|pancreas(1)	2		Ovarian(192;0.0731)|all_neural(266;0.196)		OV - Ovarian serous cystadenocarcinoma(262;0.000196)|all cancers(93;0.00192)|GBM - Glioblastoma multiforme(486;0.0499)|Epithelial(262;0.0504)														---	---	---	---
PRKD2	25865	broad.mit.edu	37	19	47200982	47200982	+	Intron	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:47200982C>T	uc002pfh.2	-						PRKD2_uc002pfe.2_5'Flank|PRKD2_uc002pff.2_5'Flank|PRKD2_uc002pfg.2_Intron|PRKD2_uc002pfi.2_Intron|PRKD2_uc002pfj.2_Intron|PRKD2_uc010xye.1_Intron|PRKD2_uc002pfk.2_Intron	NM_001079881	NP_001073350			protein kinase D2 isoform A						cell death|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|T cell receptor signaling pathway	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein kinase C activity			ovary(2)|central_nervous_system(2)|stomach(1)|large_intestine(1)|lung(1)	7		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000189)|all cancers(93;0.000545)|Epithelial(262;0.0219)|GBM - Glioblastoma multiforme(486;0.0353)														---	---	---	---
SLC1A5	6510	broad.mit.edu	37	19	47278762	47278762	+	3'UTR	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:47278762G>T	uc002pfs.2	-	8					SLC1A5_uc010xyh.1_3'UTR|SLC1A5_uc002pfq.2_3'UTR|SLC1A5_uc002pfr.2_3'UTR	NM_005628	NP_005619			solute carrier family 1 member 5 isoform 1						cellular nitrogen compound metabolic process	integral to plasma membrane|melanosome|membrane fraction	neutral amino acid transmembrane transporter activity|protein binding|receptor activity|sodium:dicarboxylate symporter activity				0		all_epithelial(76;0.00314)|Ovarian(192;0.0798)|all_neural(266;0.107)		OV - Ovarian serous cystadenocarcinoma(262;0.000338)|all cancers(93;0.000882)|Epithelial(262;0.0211)|GBM - Glioblastoma multiforme(486;0.0341)	L-Asparagine(DB00174)|L-Glutamine(DB00130)													---	---	---	---
GRLF1	2909	broad.mit.edu	37	19	47422063	47422063	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:47422063G>A	uc010ekv.2	+	1	131	c.131G>A	c.(130-132)CGC>CAC	p.R44H		NM_004491	NP_004482	Q9NRY4	RHG35_HUMAN	glucocorticoid receptor DNA binding factor 1	44					axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity			central_nervous_system(1)	1		all_cancers(25;1.51e-09)|all_epithelial(76;1.87e-07)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|Ovarian(192;0.0129)|all_neural(266;0.026)|Breast(70;0.077)		all cancers(93;2.03e-05)|OV - Ovarian serous cystadenocarcinoma(262;2.57e-05)|Epithelial(262;0.00135)|GBM - Glioblastoma multiforme(486;0.0289)														---	---	---	---
DHX34	9704	broad.mit.edu	37	19	47884088	47884088	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:47884088C>T	uc010xyn.1	+	15	3339	c.2998C>T	c.(2998-3000)CGG>TGG	p.R1000W	DHX34_uc010xyo.1_Missense_Mutation_p.R129W	NM_014681	NP_055496	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	1000						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)														---	---	---	---
FAM83E	54854	broad.mit.edu	37	19	49106851	49106851	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49106851C>T	uc002pjn.2	-	4	1141	c.1076G>A	c.(1075-1077)CGC>CAC	p.R359H		NM_017708	NP_060178	Q2M2I3	FA83E_HUMAN	hypothetical protein LOC54854	359										ovary(1)	1		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)														---	---	---	---
FAM83E	54854	broad.mit.edu	37	19	49116511	49116511	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49116511C>T	uc002pjn.2	-	1	184	c.119G>A	c.(118-120)AGC>AAC	p.S40N		NM_017708	NP_060178	Q2M2I3	FA83E_HUMAN	hypothetical protein LOC54854	40										ovary(1)	1		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)														---	---	---	---
NOSIP	51070	broad.mit.edu	37	19	50059938	50059938	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50059938G>A	uc002pok.2	-	8	745	c.593C>T	c.(592-594)ACG>ATG	p.T198M	NOSIP_uc002pol.2_Missense_Mutation_p.T198M	NM_015953	NP_057037	Q9Y314	NOSIP_HUMAN	nitric oxide synthase interacting protein	198					negative regulation of nitric-oxide synthase activity|nitric oxide metabolic process	cytosol|nucleus	protein binding			skin(1)	1		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00321)|GBM - Glioblastoma multiforme(134;0.0133)														---	---	---	---
CPT1C	126129	broad.mit.edu	37	19	50208489	50208489	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50208489C>T	uc002ppj.2	+	9	1103	c.898C>T	c.(898-900)CGC>TGC	p.R300C	CPT1C_uc002ppl.3_Missense_Mutation_p.R266C|CPT1C_uc002ppi.2_Missense_Mutation_p.R217C|CPT1C_uc002ppk.2_Missense_Mutation_p.R289C|CPT1C_uc010eng.2_Missense_Mutation_p.R300C|CPT1C_uc010enh.2_Missense_Mutation_p.R300C|CPT1C_uc010ybc.1_Missense_Mutation_p.R171C|CPT1C_uc010eni.1_5'Flank	NM_152359	NP_689572	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C isoform 2	300	Cytoplasmic (Potential).				fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)														---	---	---	---
PTOV1	53635	broad.mit.edu	37	19	50360333	50360333	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50360333C>T	uc002pqf.1	+	6	830	c.660C>T	c.(658-660)TAC>TAT	p.Y220Y	PTOV1_uc002ppz.3_RNA|PTOV1_uc002pqb.3_Silent_p.Y188Y|PTOV1_uc002pqa.2_RNA|PTOV1_uc002pqc.1_RNA|PTOV1_uc002pqd.2_RNA|PTOV1_uc002pqe.1_RNA	NM_017432	NP_059128	Q86YD1	PTOV1_HUMAN	prostate tumor overexpressed 1	220	Interaction with FLOT1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|plasma membrane					0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.0132)														---	---	---	---
ZNF473	25888	broad.mit.edu	37	19	50549260	50549260	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50549260C>T	uc002prn.2	+	5	1797	c.1560C>T	c.(1558-1560)TGC>TGT	p.C520C	ZNF473_uc002prm.2_Silent_p.C520C|ZNF473_uc010ybo.1_Silent_p.C508C	NM_001006656	NP_001006657	Q8WTR7	ZN473_HUMAN	zinc finger protein 473	520	C2H2-type 10.|Interaction with SLBP/pre-mRNA complex.				histone mRNA 3'-end processing|regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription	Cajal body	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00111)|OV - Ovarian serous cystadenocarcinoma(262;0.0058)														---	---	---	---
SHANK1	50944	broad.mit.edu	37	19	51220008	51220008	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:51220008G>T	uc002psx.1	-	1	188	c.169C>A	c.(169-171)CTC>ATC	p.L57I		NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	57					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)														---	---	---	---
CD33	945	broad.mit.edu	37	19	51728620	51728620	+	Missense_Mutation	SNP	C	T	T	rs138300409	byFrequency	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:51728620C>T	uc002pwa.2	+	2	224	c.184C>T	c.(184-186)CGG>TGG	p.R62W	CD33_uc010eos.1_Missense_Mutation_p.R62W|CD33_uc010eot.1_Intron|CD33_uc010eou.1_5'Flank	NM_001772	NP_001763	P20138	CD33_HUMAN	CD33 antigen isoform 1 precursor	62	Extracellular (Potential).|Ig-like V-type.				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding				0		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)													---	---	---	---
ZNF836	162962	broad.mit.edu	37	19	52660326	52660326	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:52660326A>G	uc010ydi.1	-	5	984	c.610T>C	c.(610-612)TTA>CTA	p.L204L	ZNF836_uc010ydj.1_Silent_p.L204L	NM_001102657	NP_001096127	Q6ZNA1	ZN836_HUMAN	zinc finger protein 836	204					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
ZNF83	55769	broad.mit.edu	37	19	53117526	53117526	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:53117526G>A	uc002pzu.3	-	2	1536	c.292C>T	c.(292-294)CGT>TGT	p.R98C	ZNF83_uc002pzv.3_Missense_Mutation_p.R98C|ZNF83_uc010eps.2_Missense_Mutation_p.R98C|ZNF83_uc010ept.2_Missense_Mutation_p.R98C|ZNF83_uc010epu.2_Missense_Mutation_p.R98C|ZNF83_uc010epv.2_Missense_Mutation_p.R98C|ZNF83_uc010epw.2_Missense_Mutation_p.R98C|ZNF83_uc010epx.2_Missense_Mutation_p.R98C|ZNF83_uc010epy.2_Missense_Mutation_p.R98C|ZNF83_uc010epz.2_Missense_Mutation_p.R98C|ZNF83_uc010eqb.1_Missense_Mutation_p.R98C	NM_018300	NP_060770	P51522	ZNF83_HUMAN	zinc finger protein 83 isoform a	98	C2H2-type 1; degenerate.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.00841)|GBM - Glioblastoma multiforme(134;0.0244)														---	---	---	---
ZNF611	81856	broad.mit.edu	37	19	53208679	53208679	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:53208679A>G	uc002pzz.2	-	7	1946	c.1629T>C	c.(1627-1629)TGT>TGC	p.C543C	ZNF611_uc010eqc.2_Silent_p.C473C|ZNF611_uc010ydo.1_Silent_p.C473C|ZNF611_uc010ydr.1_Silent_p.C474C|ZNF611_uc010ydp.1_Silent_p.C543C|ZNF611_uc010ydq.1_Silent_p.C543C|ZNF611_uc002qaa.3_Silent_p.C473C	NM_030972	NP_112234	Q8N823	ZN611_HUMAN	zinc finger protein 611 isoform a	543	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.0233)|GBM - Glioblastoma multiforme(134;0.04)														---	---	---	---
LILRA3	11026	broad.mit.edu	37	19	54802622	54802622	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54802622G>T	uc002qfd.2	-	5	884	c.819C>A	c.(817-819)CCC>CCA	p.P273P	LILRA6_uc002qew.1_Intron|LILRA3_uc010erk.2_Silent_p.P209P	NM_006865	NP_006856	Q8N6C8	LIRA3_HUMAN	leukocyte immunoglobulin-like receptor,	273	Ig-like C2-type 3.				defense response	extracellular region|plasma membrane	antigen binding|receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)														---	---	---	---
LILRA3	11026	broad.mit.edu	37	19	54802639	54802639	+	Missense_Mutation	SNP	G	A	A	rs143103718	byFrequency	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54802639G>A	uc002qfd.2	-	5	867	c.802C>T	c.(802-804)CGC>TGC	p.R268C	LILRA6_uc002qew.1_Intron|LILRA3_uc010erk.2_Missense_Mutation_p.R204C	NM_006865	NP_006856	Q8N6C8	LIRA3_HUMAN	leukocyte immunoglobulin-like receptor,	268	Ig-like C2-type 3.				defense response	extracellular region|plasma membrane	antigen binding|receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)														---	---	---	---
TTYH1	57348	broad.mit.edu	37	19	54946839	54946839	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54946839C>A	uc002qfq.2	+	11	1335	c.1243C>A	c.(1243-1245)CGA>AGA	p.R415R	TTYH1_uc010yey.1_Missense_Mutation_p.P445Q|TTYH1_uc002qfr.2_Silent_p.R415R|TTYH1_uc002qft.2_Silent_p.R415R	NM_020659	NP_065710	Q9H313	TTYH1_HUMAN	tweety 1 isoform 1	415	Cytoplasmic (Potential).				cell adhesion	chloride channel complex|plasma membrane	chloride channel activity|iron ion transmembrane transporter activity				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0767)														---	---	---	---
LENG9	94059	broad.mit.edu	37	19	54973590	54973590	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54973590G>T	uc010yez.1	-	1	1305	c.1186C>A	c.(1186-1188)CCT>ACT	p.P396T		NM_198988	NP_945339	Q96B70	LENG9_HUMAN	leukocyte receptor cluster (LRC) member 9	396					RNA metabolic process	intracellular	catalytic activity|nucleic acid binding|zinc ion binding				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.134)														---	---	---	---
LENG9	94059	broad.mit.edu	37	19	54974255	54974255	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54974255G>A	uc010yez.1	-	1	640	c.521C>T	c.(520-522)GCG>GTG	p.A174V		NM_198988	NP_945339	Q96B70	LENG9_HUMAN	leukocyte receptor cluster (LRC) member 9	174					RNA metabolic process	intracellular	catalytic activity|nucleic acid binding|zinc ion binding				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.134)														---	---	---	---
EPS8L1	54869	broad.mit.edu	37	19	55598886	55598886	+	Intron	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55598886C>A	uc002qis.3	+						EPS8L1_uc010yfr.1_Intron|EPS8L1_uc002qiu.2_Intron|EPS8L1_uc002qiv.2_Intron|EPS8L1_uc002qiw.2_Intron	NM_133180	NP_573441			epidermal growth factor receptor pathway							cytoplasm					0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)														---	---	---	---
ZNF71	58491	broad.mit.edu	37	19	57132978	57132978	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:57132978G>A	uc002qnm.3	+	3	561	c.323G>A	c.(322-324)GGC>GAC	p.G108D		NM_021216	NP_067039	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	108						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)														---	---	---	---
ZIM3	114026	broad.mit.edu	37	19	57647283	57647283	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:57647283A>G	uc002qnz.1	-	5	808	c.422T>C	c.(421-423)GTA>GCA	p.V141A		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	141					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)														---	---	---	---
ZNF543	125919	broad.mit.edu	37	19	57840578	57840578	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:57840578A>G	uc002qoi.1	+	4	2093	c.1748A>G	c.(1747-1749)GAA>GGA	p.E583G		NM_213598	NP_998763	Q08ER8	ZN543_HUMAN	zinc finger protein 543	583					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)|pancreas(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)														---	---	---	---
ZNF419	79744	broad.mit.edu	37	19	58005213	58005213	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58005213A>G	uc002qov.2	+	5	1528	c.1288A>G	c.(1288-1290)AGG>GGG	p.R430G	ZNF547_uc002qpm.3_Intron|ZNF419_uc010ety.1_Missense_Mutation_p.R431G|ZNF419_uc010etz.1_Missense_Mutation_p.R418G|ZNF419_uc010eua.1_Missense_Mutation_p.R417G|ZNF419_uc002qow.2_Missense_Mutation_p.R398G|ZNF419_uc010eub.1_Missense_Mutation_p.R385G|ZNF419_uc010euc.1_Missense_Mutation_p.R384G	NM_024691	NP_078967	Q96HQ0	ZN419_HUMAN	zinc finger protein 419 isoform 2	430	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0252)|Lung(386;0.171)														---	---	---	---
ZNF773	374928	broad.mit.edu	37	19	58018753	58018753	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58018753T>C	uc002qox.2	+	4	1430	c.1290T>C	c.(1288-1290)CTT>CTC	p.L430L	ZNF547_uc002qpm.3_Intron|ZNF773_uc002qoy.2_Silent_p.L429L|ZNF773_uc002qoz.2_Intron	NM_198542	NP_940944	Q6PK81	ZN773_HUMAN	zinc finger protein 773	430	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0254)														---	---	---	---
ZNF211	10520	broad.mit.edu	37	19	58146129	58146129	+	Intron	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58146129G>A	uc002qpq.2	+						ZNF211_uc010yhb.1_Intron|ZNF211_uc002qpp.2_Intron|ZNF211_uc002qpr.2_Intron|ZNF211_uc002qps.2_Intron|ZNF211_uc002qpt.2_Intron|ZNF211_uc010yhc.1_Intron|ZNF211_uc010yhd.1_Intron|ZNF211_uc010yhe.1_Intron	NM_198855	NP_942152			zinc finger protein 211 isoform 2							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)														---	---	---	---
ZNF552	79818	broad.mit.edu	37	19	58320259	58320259	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58320259C>A	uc002qqg.2	-	3	543	c.373G>T	c.(373-375)GGG>TGG	p.G125W	ZNF587_uc002qqb.2_Intron|ZNF552_uc010yhg.1_Missense_Mutation_p.G121W	NM_024762	NP_079038	Q9H707	ZN552_HUMAN	zinc finger protein 552	125	C2H2-type 2; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0259)														---	---	---	---
ZNF135	7694	broad.mit.edu	37	19	58573064	58573064	+	Silent	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58573064G>T	uc010yhq.1	+	3	246	c.150G>T	c.(148-150)CTG>CTT	p.L50L	ZNF135_uc002qre.2_Silent_p.L50L|ZNF135_uc002qrd.1_Silent_p.L8L|ZNF135_uc002qrf.2_Silent_p.L8L|ZNF135_uc002qrg.2_Silent_p.L8L|ZNF135_uc010yhr.1_Intron	NM_003436	NP_003427	B4DHH9	B4DHH9_HUMAN	zinc finger protein 135 isoform 2	50					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0161)														---	---	---	---
ZNF497	162968	broad.mit.edu	37	19	58867759	58867759	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58867759C>T	uc002qsh.1	-	3	1432	c.1243G>A	c.(1243-1245)GCC>ACC	p.A415T	A1BG_uc002qsd.3_5'Flank|A1BG_uc002qsf.1_Intron|ZNF497_uc002qsi.1_Missense_Mutation_p.A415T|uc002qsj.1_5'Flank|uc002qsk.1_5'Flank	NM_198458	NP_940860	Q6ZNH5	ZN497_HUMAN	zinc finger protein 497	415	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)	2		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0278)														---	---	---	---
ZNF446	55663	broad.mit.edu	37	19	58991071	58991071	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58991071A>C	uc002qsz.2	+	5	806	c.689A>C	c.(688-690)AAG>ACG	p.K230T	ZNF446_uc002qta.2_Intron|ZNF446_uc010eur.2_Missense_Mutation_p.K230T|SLC27A5_uc002qtb.2_RNA	NM_017908	NP_060378	Q9NWS9	ZN446_HUMAN	zinc finger protein 446	230	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)														---	---	---	---
TGM3	7053	broad.mit.edu	37	20	2312896	2312896	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:2312896G>T	uc002wfx.3	+	10	1679	c.1582G>T	c.(1582-1584)GGC>TGC	p.G528C		NM_003245	NP_003236	Q08188	TGM3_HUMAN	transglutaminase 3 precursor	528					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(4)|ovary(3)|breast(1)|skin(1)	9					L-Glutamine(DB00130)													---	---	---	---
SIGLEC1	6614	broad.mit.edu	37	20	3672650	3672650	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:3672650C>T	uc002wja.2	-	16	4230	c.4230G>A	c.(4228-4230)CGG>CGA	p.R1410R	SIGLEC1_uc002wjb.1_Silent_p.R49R|SIGLEC1_uc002wiz.3_Silent_p.R1410R	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	1410	Ig-like C2-type 14.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10																		---	---	---	---
FLRT3	23767	broad.mit.edu	37	20	14306292	14306292	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:14306292T>C	uc002wov.1	-	3	2328	c.1861A>G	c.(1861-1863)AAT>GAT	p.N621D	MACROD2_uc002wot.2_Intron|MACROD2_uc002wou.2_Intron|FLRT3_uc002wow.1_Missense_Mutation_p.N621D	NM_198391	NP_938205	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	621	Cytoplasmic (Potential).				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			kidney(1)	1		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)														---	---	---	---
KIF16B	55614	broad.mit.edu	37	20	16359766	16359766	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:16359766C>T	uc002wpg.1	-	19	3039	c.2881G>A	c.(2881-2883)GCC>ACC	p.A961T	KIF16B_uc002wpe.1_Missense_Mutation_p.A343T|KIF16B_uc002wpf.1_Missense_Mutation_p.A343T|KIF16B_uc010gch.1_Missense_Mutation_p.A961T|KIF16B_uc010gci.1_Missense_Mutation_p.A961T|KIF16B_uc010gcj.1_Missense_Mutation_p.A972T	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	961	Glu-rich.|Potential.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8																		---	---	---	---
KIF16B	55614	broad.mit.edu	37	20	16488669	16488669	+	Silent	SNP	G	T	T	rs140728844		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:16488669G>T	uc002wpg.1	-	7	791	c.633C>A	c.(631-633)ACC>ACA	p.T211T	KIF16B_uc010gch.1_Silent_p.T211T|KIF16B_uc010gci.1_Silent_p.T211T|KIF16B_uc010gcj.1_Silent_p.T211T	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	211	Kinesin-motor.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8																		---	---	---	---
CSRP2BP	57325	broad.mit.edu	37	20	18123412	18123412	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:18123412G>A	uc002wqj.2	+	2	730	c.108G>A	c.(106-108)ACG>ACA	p.T36T	CSRP2BP_uc002wqk.2_5'Flank	NM_020536	NP_065397	Q9H8E8	CSR2B_HUMAN	CSRP2 binding protein	36					histone H3 acetylation	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm	LIM domain binding|N-acetyltransferase activity			lung(3)|ovary(2)|skin(1)	6																		---	---	---	---
C20orf26	26074	broad.mit.edu	37	20	20180465	20180465	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:20180465C>A	uc002wru.2	+	17	1927	c.1851C>A	c.(1849-1851)CCC>CCA	p.P617P	C20orf26_uc010zse.1_Silent_p.P597P	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	617										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)														---	---	---	---
PAX1	5075	broad.mit.edu	37	20	21687475	21687475	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:21687475C>T	uc002wsj.2	+	2	740	c.686C>T	c.(685-687)GCG>GTG	p.A229V	PAX1_uc010zsl.1_Missense_Mutation_p.A229V|PAX1_uc010zsm.1_Missense_Mutation_p.A205V	NM_006192	NP_006183	P15863	PAX1_HUMAN	paired box 1	229					regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			upper_aerodigestive_tract(1)|kidney(1)	2																		---	---	---	---
NINL	22981	broad.mit.edu	37	20	25456684	25456684	+	Silent	SNP	G	A	A	rs144098143	byFrequency	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:25456684G>A	uc002wux.1	-	17	3317	c.3243C>T	c.(3241-3243)AAC>AAT	p.N1081N	NINL_uc010gdn.1_Intron	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	1081	Potential.				G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5																		---	---	---	---
TPX2	22974	broad.mit.edu	37	20	30365384	30365384	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:30365384G>T	uc002wwp.1	+	9	1523	c.825G>T	c.(823-825)CAG>CAT	p.Q275H	TPX2_uc010gdv.1_Missense_Mutation_p.Q275H	NM_012112	NP_036244	Q9ULW0	TPX2_HUMAN	TPX2, microtubule-associated protein homolog	275					activation of protein kinase activity|apoptosis|cell division|cell proliferation|mitosis|regulation of mitotic spindle organization	cytoplasm|microtubule|nucleus|spindle pole	ATP binding|GTP binding|protein kinase binding			large_intestine(1)|ovary(1)	2			Epithelial(4;0.000771)|Colorectal(19;0.00306)|all cancers(5;0.004)|COAD - Colon adenocarcinoma(19;0.0347)|OV - Ovarian serous cystadenocarcinoma(3;0.0656)															---	---	---	---
PLAGL2	5326	broad.mit.edu	37	20	30784742	30784742	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:30784742G>T	uc002wxn.2	-	3	1221	c.1004C>A	c.(1003-1005)CCA>CAA	p.P335Q		NM_002657	NP_002648	Q9UPG8	PLAL2_HUMAN	pleiomorphic adenoma gene-like 2	335						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)															---	---	---	---
DNMT3B	1789	broad.mit.edu	37	20	31387087	31387087	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:31387087G>A	uc002wyc.2	+	16	2033	c.1712G>A	c.(1711-1713)CGA>CAA	p.R571Q	DNMT3B_uc010zty.1_RNA|DNMT3B_uc002wyd.2_Missense_Mutation_p.R551Q|DNMT3B_uc002wye.2_Missense_Mutation_p.R551Q|DNMT3B_uc010gee.2_RNA|DNMT3B_uc010gef.2_RNA|DNMT3B_uc010ztz.1_Missense_Mutation_p.R509Q|DNMT3B_uc010zua.1_Missense_Mutation_p.R475Q|DNMT3B_uc002wyf.2_Missense_Mutation_p.R563Q|DNMT3B_uc002wyg.2_Missense_Mutation_p.R270Q|DNMT3B_uc010geg.2_5'Flank|DNMT3B_uc010geh.2_5'Flank	NM_006892	NP_008823	Q9UBC3	DNM3B_HUMAN	DNA cytosine-5 methyltransferase 3 beta isoform	571					negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			lung(3)|ovary(2)	5																		---	---	---	---
MAPRE1	22919	broad.mit.edu	37	20	31427577	31427577	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:31427577C>T	uc002wyh.2	+	5	651	c.512C>T	c.(511-513)GCG>GTG	p.A171V		NM_012325	NP_036457	Q15691	MARE1_HUMAN	microtubule-associated protein, RP/EB family,	171	Interaction with MTUS2/TIP150.				cell division|cell proliferation|G2/M transition of mitotic cell cycle|mitotic prometaphase|negative regulation of microtubule polymerization|protein localization to microtubule	centrosome|cortical microtubule cytoskeleton|cytosol	microtubule plus-end binding|protein C-terminus binding				0																		---	---	---	---
SUN5	140732	broad.mit.edu	37	20	31577420	31577420	+	Intron	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:31577420A>G	uc002wyi.2	-							NM_080675	NP_542406			sperm associated antigen 4-like						spermatogenesis					skin(1)	1																		---	---	---	---
AHCY	191	broad.mit.edu	37	20	32878616	32878616	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:32878616G>A	uc002xai.2	-	6	826	c.687C>T	c.(685-687)GCC>GCT	p.A229A	AHCY_uc002xaj.2_Silent_p.A201A	NM_000687	NP_000678	P23526	SAHH_HUMAN	adenosylhomocysteinase isoform 1	229					methylation|xenobiotic metabolic process	cytosol|melanosome	adenosylhomocysteinase activity|protein binding				0																		---	---	---	---
GGT7	2686	broad.mit.edu	37	20	33451198	33451198	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:33451198G>A	uc002xay.2	-	2	366	c.323C>T	c.(322-324)ACG>ATG	p.T108M	GGT7_uc002xaz.1_Missense_Mutation_p.T125M|GGT7_uc002xba.1_Missense_Mutation_p.T108M	NM_178026	NP_821158	Q9UJ14	GGT7_HUMAN	gamma-glutamyltransferase 7	108	Helical; Signal-anchor for type II membrane protein; (Potential).				glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity			ovary(1)	1																		---	---	---	---
GSS	2937	broad.mit.edu	37	20	33530761	33530761	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:33530761C>T	uc002xbg.2	-	4	404	c.324G>A	c.(322-324)AAG>AAA	p.K108K	GSS_uc010zun.1_5'UTR|GSS_uc010zuo.1_Intron|GSS_uc010zup.1_Silent_p.K39K|GSS_uc002xbh.2_RNA|GSS_uc010gez.1_5'UTR	NM_000178	NP_000169	P48637	GSHB_HUMAN	glutathione synthetase	108					nervous system development|response to oxidative stress|xenobiotic metabolic process	cytosol	ATP binding|glutathione binding|glutathione synthase activity|magnesium ion binding|protein homodimerization activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(18;0.035)		Glutathione(DB00143)|Glycine(DB00145)|L-Cysteine(DB00151)													---	---	---	---
SNHG11	128439	broad.mit.edu	37	20	37078014	37078014	+	Intron	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:37078014C>T	uc002xiq.1	+						SNHG11_uc002xir.1_Intron|SNHG11_uc002xis.1_Intron|SNHG11_uc002xit.1_Intron|SNHG11_uc002xiu.1_Intron|SNORA39_uc002xip.2_RNA	NR_003239				Homo sapiens hypothetical protein mRNA, complete cds.												0																		---	---	---	---
SLC32A1	140679	broad.mit.edu	37	20	37356949	37356949	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:37356949C>T	uc002xjc.2	+	2	1508	c.1245C>T	c.(1243-1245)CGC>CGT	p.R415R		NM_080552	NP_542119	Q9H598	VIAAT_HUMAN	solute carrier family 32, member 1	415	Lumenal, vesicle (Potential).				neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity				0		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)													---	---	---	---
DHX35	60625	broad.mit.edu	37	20	37652340	37652340	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:37652340T>C	uc002xjh.2	+	17	1612	c.1601T>C	c.(1600-1602)GTG>GCG	p.V534A	DHX35_uc010zwa.1_Missense_Mutation_p.V379A|DHX35_uc010zwb.1_Missense_Mutation_p.V379A|DHX35_uc010zwc.1_Missense_Mutation_p.V503A	NM_021931	NP_068750	Q9H5Z1	DHX35_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 35	534						catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|nucleic acid binding			lung(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)																---	---	---	---
PTPRT	11122	broad.mit.edu	37	20	40911166	40911166	+	Splice_Site	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:40911166C>T	uc002xkg.2	-	13	2324	c.2140_splice	c.e13-1	p.E714_splice	PTPRT_uc010ggj.2_Splice_Site_p.E714_splice	NM_007050	NP_008981			protein tyrosine phosphatase, receptor type, T						homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)																---	---	---	---
IFT52	51098	broad.mit.edu	37	20	42252676	42252676	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:42252676G>T	uc002xkw.2	+	10	1036	c.914G>T	c.(913-915)AGC>ATC	p.S305I	IFT52_uc002xky.2_Missense_Mutation_p.S305I|IFT52_uc002xkx.2_RNA|IFT52_uc010ggn.2_Missense_Mutation_p.S281I|IFT52_uc002xkz.2_Missense_Mutation_p.S305I	NM_016004	NP_057088	Q9Y366	IFT52_HUMAN	intraflagellar transport 52 homolog	305						intraflagellar transport particle B|microtubule-based flagellum	protein C-terminus binding			ovary(2)	2		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)															---	---	---	---
SERINC3	10955	broad.mit.edu	37	20	43141554	43141554	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:43141554A>G	uc002xme.2	-	3	417	c.283T>C	c.(283-285)TAT>CAT	p.Y95H	SERINC3_uc002xmf.1_Missense_Mutation_p.Y95H|SERINC3_uc010ggs.1_Missense_Mutation_p.Y88H|SERINC3_uc010zwp.1_Missense_Mutation_p.Y40H	NM_198941	NP_945179	Q13530	SERC3_HUMAN	tumor differentially expressed protein 1	95	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			skin(3)	3		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.000291)|COAD - Colon adenocarcinoma(18;0.00189)															---	---	---	---
KCNS1	3787	broad.mit.edu	37	20	43727239	43727239	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:43727239G>A	uc002xnc.2	-	4	571	c.174C>T	c.(172-174)GGC>GGT	p.G58G	KCNS1_uc002xnd.2_Silent_p.G58G	NM_002251	NP_002242	Q96KK3	KCNS1_HUMAN	potassium voltage-gated channel	58	Cytoplasmic (Potential).					voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity|protein binding				0		Myeloproliferative disorder(115;0.0122)																---	---	---	---
PIGT	51604	broad.mit.edu	37	20	44048961	44048961	+	Intron	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:44048961C>T	uc002xoh.1	+						PIGT_uc010ghb.1_Intron|PIGT_uc010zwt.1_Intron|PIGT_uc010ghd.1_Intron|PIGT_uc010ghc.1_Intron|PIGT_uc010ghe.1_Intron|PIGT_uc010ghf.1_Intron|PIGT_uc002xoj.1_Intron|PIGT_uc002xok.1_Intron|PIGT_uc010zwu.1_Intron|PIGT_uc002xoi.1_Intron|PIGT_uc010zwv.1_Intron|PIGT_uc010zww.1_Intron|PIGT_uc010zwx.1_Intron|PIGT_uc010zwy.1_Intron|PIGT_uc010zwz.1_Intron|PIGT_uc010zxa.1_Intron|PIGT_uc002xol.1_Intron|PIGT_uc010zxb.1_Intron	NM_015937	NP_057021			phosphatidylinositol glycan anchor biosynthesis,						attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			pancreas(1)	1		Myeloproliferative disorder(115;0.0122)																---	---	---	---
ZSWIM3	140831	broad.mit.edu	37	20	44505669	44505669	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:44505669T>C	uc002xqd.2	+	2	675	c.472T>C	c.(472-474)TCC>CCC	p.S158P	ZSWIM3_uc010zxg.1_Missense_Mutation_p.S152P	NM_080752	NP_542790	Q96MP5	ZSWM3_HUMAN	zinc finger, SWIM domain containing 3	158							zinc ion binding			ovary(2)	2		Myeloproliferative disorder(115;0.0122)																---	---	---	---
CD40	958	broad.mit.edu	37	20	44747031	44747031	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:44747031G>A	uc002xrg.1	+	1	126	c.49G>A	c.(49-51)GCT>ACT	p.A17T	CD40_uc002xrf.1_Missense_Mutation_p.A17T|CD40_uc002xrh.1_Missense_Mutation_p.A17T|CD40_uc002xri.1_Missense_Mutation_p.A17T|CD40_uc002xrj.1_RNA|CD40_uc002xrk.1_RNA	NM_001250	NP_001241	P25942	TNR5_HUMAN	CD40 antigen isoform 1 precursor	17					B cell proliferation|cellular response to mechanical stimulus|inflammatory response|platelet activation|positive regulation of endothelial cell apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein complex assembly	CD40 receptor complex|extracellular region	enzyme binding|receptor activity			lung(1)|skin(1)	2		Myeloproliferative disorder(115;0.0122)			Simvastatin(DB00641)									Immune_Deficiency_with_Hyper-IgM				---	---	---	---
CDH22	64405	broad.mit.edu	37	20	44839105	44839105	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:44839105C>T	uc002xrm.2	-	6	1528	c.1127G>A	c.(1126-1128)CGC>CAC	p.R376H	CDH22_uc010ghk.1_Missense_Mutation_p.R376H|CDH22_uc002xrn.1_Missense_Mutation_p.R127H	NM_021248	NP_067071	Q9UJ99	CAD22_HUMAN	cadherin 22 precursor	376	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|skin(1)	5		Myeloproliferative disorder(115;0.0122)																---	---	---	---
ZNF334	55713	broad.mit.edu	37	20	45130215	45130215	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:45130215A>G	uc002xsc.2	-	5	1947	c.1763T>C	c.(1762-1764)GTT>GCT	p.V588A	ZNF334_uc002xsa.2_Missense_Mutation_p.V611A|ZNF334_uc002xsb.2_Missense_Mutation_p.V550A|ZNF334_uc002xsd.2_Missense_Mutation_p.V550A|ZNF334_uc010ghl.2_Missense_Mutation_p.V587A	NM_018102	NP_060572	Q9HCZ1	ZN334_HUMAN	zinc finger protein 334 isoform a	588	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)																---	---	---	---
NCOA3	8202	broad.mit.edu	37	20	46265284	46265284	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:46265284C>T	uc002xtk.2	+	12	2359	c.2154C>T	c.(2152-2154)GAC>GAT	p.D718D	NCOA3_uc010ght.1_Silent_p.D728D|NCOA3_uc002xtl.2_Silent_p.D718D|NCOA3_uc002xtm.2_Silent_p.D718D|NCOA3_uc002xtn.2_Silent_p.D718D|NCOA3_uc010zyc.1_Silent_p.D513D	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3 isoform a	718					androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5																		---	---	---	---
SPATA2	9825	broad.mit.edu	37	20	48522877	48522877	+	Missense_Mutation	SNP	G	A	A	rs140549434		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:48522877G>A	uc010gie.2	-	3	1192	c.842C>T	c.(841-843)ACG>ATG	p.T281M	SPATA2_uc002xuw.2_Missense_Mutation_p.T281M|SPATA2_uc010zyn.1_Missense_Mutation_p.T144M	NM_001135773	NP_001129245	Q9UM82	SPAT2_HUMAN	spermatogenesis associated 2	281					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|nucleus				central_nervous_system(1)|skin(1)	2	Hepatocellular(150;0.133)		BRCA - Breast invasive adenocarcinoma(9;4.03e-06)															---	---	---	---
ADNP	23394	broad.mit.edu	37	20	49510674	49510674	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:49510674C>A	uc002xvt.1	-	5	922	c.577G>T	c.(577-579)GCA>TCA	p.A193S	ADNP_uc002xvu.1_Missense_Mutation_p.A193S	NM_015339	NP_056154	Q9H2P0	ADNP_HUMAN	activity-dependent neuroprotector	193						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2																		---	---	---	---
ADNP	23394	broad.mit.edu	37	20	49510754	49510754	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:49510754T>C	uc002xvt.1	-	5	842	c.497A>G	c.(496-498)TAC>TGC	p.Y166C	ADNP_uc002xvu.1_Missense_Mutation_p.Y166C	NM_015339	NP_056154	Q9H2P0	ADNP_HUMAN	activity-dependent neuroprotector	166	C2H2-type 3.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2																		---	---	---	---
ZFP64	55734	broad.mit.edu	37	20	50705027	50705027	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:50705027G>A	uc002xwk.2	-	8	1481	c.1132C>T	c.(1132-1134)CGG>TGG	p.R378W	ZFP64_uc002xwj.2_Missense_Mutation_p.R159W	NM_199427	NP_955459	Q9NPA5	ZF64A_HUMAN	zinc finger protein 64 isoform d	335	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2																		---	---	---	---
ZFP64	55734	broad.mit.edu	37	20	50769628	50769628	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:50769628T>C	uc002xwl.2	-	6	1452	c.1103A>G	c.(1102-1104)GAC>GGC	p.D368G	ZFP64_uc002xwk.2_Intron|ZFP64_uc002xwm.2_Missense_Mutation_p.D366G|ZFP64_uc002xwn.2_Missense_Mutation_p.D314G	NM_018197	NP_060667	Q9NPA5	ZF64A_HUMAN	zinc finger protein 64 isoform a	368					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2																		---	---	---	---
TSHZ2	128553	broad.mit.edu	37	20	51872037	51872037	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:51872037C>T	uc002xwo.2	+	2	2996	c.2040C>T	c.(2038-2040)TGC>TGT	p.C680C		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	680					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)															---	---	---	---
BCAS1	8537	broad.mit.edu	37	20	52645436	52645436	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:52645436G>A	uc002xws.2	-	4	556	c.218C>T	c.(217-219)GCG>GTG	p.A73V	BCAS1_uc010zzb.1_5'UTR|BCAS1_uc010gim.2_5'UTR|BCAS1_uc002xwt.2_Missense_Mutation_p.A73V|BCAS1_uc010gil.1_Missense_Mutation_p.A73V|BCAS1_uc010zzc.1_5'UTR	NM_003657	NP_003648	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	73						cytoplasm	protein binding			ovary(2)|central_nervous_system(1)	3	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)															---	---	---	---
TH1L	51497	broad.mit.edu	37	20	57568830	57568830	+	Intron	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:57568830C>T	uc002yag.2	+						TH1L_uc002yaf.1_Intron|TH1L_uc002yah.2_Intron	NM_198976	NP_945327			TH1-like protein						negative regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3	all_lung(29;0.00711)		Colorectal(105;0.109)															---	---	---	---
TUBB1	81027	broad.mit.edu	37	20	57597917	57597917	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:57597917T>C	uc002yak.2	+	2	344	c.75T>C	c.(73-75)GGT>GGC	p.G25G		NM_030773	NP_110400	Q9H4B7	TBB1_HUMAN	beta tubulin 1, class VI	25					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity			ovary(1)	1	all_lung(29;0.00711)		Colorectal(105;0.109)		Colchicine(DB01394)|Docetaxel(DB01248)|Paclitaxel(DB01229)|Vindesine(DB00309)													---	---	---	---
ZNF831	128611	broad.mit.edu	37	20	57769627	57769627	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:57769627T>C	uc002yan.2	+	1	3553	c.3553T>C	c.(3553-3555)TGG>CGG	p.W1185R		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1185						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)																	---	---	---	---
PHACTR3	116154	broad.mit.edu	37	20	58381176	58381176	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:58381176C>A	uc002yau.2	+	8	1722	c.1255C>A	c.(1255-1257)CGG>AGG	p.R419R	PHACTR3_uc002yat.2_Silent_p.R416R|PHACTR3_uc010zzw.1_Silent_p.R378R|PHACTR3_uc002yav.2_Silent_p.R378R|PHACTR3_uc002yaw.2_Silent_p.R378R|PHACTR3_uc002yax.2_Silent_p.R308R	NM_080672	NP_542403	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3 isoform 1	419	RPEL 2.					nuclear matrix	actin binding|protein phosphatase inhibitor activity			ovary(2)|pancreas(1)	3	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)															---	---	---	---
PPP1R3D	5509	broad.mit.edu	37	20	58514148	58514148	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:58514148C>T	uc002ybb.2	-	1	1205	c.839G>A	c.(838-840)CGC>CAC	p.R280H	C20orf177_uc002yba.2_Intron|C20orf177_uc010zzx.1_5'Flank|C20orf177_uc002ybc.2_5'Flank	NM_006242	NP_006233	O95685	PPR3D_HUMAN	protein phosphatase 1, regulatory subunit 3D	280					glycogen metabolic process		protein binding|protein serine/threonine phosphatase activity				0	all_lung(29;0.00391)		BRCA - Breast invasive adenocarcinoma(7;5.12e-09)															---	---	---	---
CDH4	1002	broad.mit.edu	37	20	60498546	60498546	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:60498546C>T	uc002ybn.1	+	10	1426	c.1412C>T	c.(1411-1413)ACA>ATA	p.T471I	CDH4_uc002ybp.1_Missense_Mutation_p.T397I	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	471	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)															---	---	---	---
CDH4	1002	broad.mit.edu	37	20	60509183	60509183	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:60509183C>T	uc002ybn.1	+	15	2463	c.2449C>T	c.(2449-2451)CGT>TGT	p.R817C	CDH4_uc002ybp.1_Missense_Mutation_p.R743C	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	817	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)															---	---	---	---
LAMA5	3911	broad.mit.edu	37	20	60887787	60887787	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:60887787A>G	uc002ycq.2	-	67	9195	c.9128T>C	c.(9127-9129)GTG>GCG	p.V3043A		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	3043	Laminin G-like 2.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
COL20A1	57642	broad.mit.edu	37	20	61943318	61943318	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:61943318G>T	uc011aau.1	+	14	1814	c.1714G>T	c.(1714-1716)GCG>TCG	p.A572S	COL20A1_uc011aav.1_Missense_Mutation_p.A393S	NM_020882	NP_065933	Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	572	Fibronectin type-III 4.				cell adhesion	collagen|extracellular space	structural molecule activity			central_nervous_system(1)	1	all_cancers(38;1.39e-10)																	---	---	---	---
PRIC285	85441	broad.mit.edu	37	20	62196027	62196027	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:62196027C>A	uc002yfm.2	-	9	5040	c.4148G>T	c.(4147-4149)GGG>GTG	p.G1383V	PRIC285_uc002yfl.1_Missense_Mutation_p.G814V	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	1383					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)															---	---	---	---
ZNF512B	57473	broad.mit.edu	37	20	62598853	62598853	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:62598853G>A	uc002yhl.1	-	3	199	c.145C>T	c.(145-147)CAG>TAG	p.Q49*		NM_020713	NP_065764	Q96KM6	Z512B_HUMAN	zinc finger protein 512B	49					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)																	---	---	---	---
OPRL1	4987	broad.mit.edu	37	20	62729410	62729410	+	Silent	SNP	G	A	A	rs141501506		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:62729410G>A	uc002yic.2	+	4	891	c.489G>A	c.(487-489)ACG>ACA	p.T163T	OPRL1_uc002yid.2_Silent_p.T163T|OPRL1_uc002yif.3_Silent_p.T158T	NM_182647	NP_872588	P41146	OPRX_HUMAN	opiate receptor-like 1	163	Cytoplasmic (Potential).				elevation of cytosolic calcium ion concentration|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception	integral to plasma membrane	protein binding|X-opioid receptor activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;4.74e-11)|all_epithelial(29;1.33e-12)|Lung NSC(23;3.27e-09)|all_lung(23;1.02e-08)																	---	---	---	---
NPBWR2	2832	broad.mit.edu	37	20	62738003	62738003	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:62738003G>A	uc011abt.1	-	1	182	c.182C>T	c.(181-183)ACT>ATT	p.T61I		NM_005286	NP_005277	P48146	NPBW2_HUMAN	neuropeptides B/W receptor 2	61	Helical; Name=1; (Potential).					plasma membrane	opioid receptor activity|protein binding			large_intestine(1)	1	all_cancers(38;2.58e-11)|all_epithelial(29;6.4e-13)|Lung NSC(23;1.25e-09)|all_lung(23;4.21e-09)																	---	---	---	---
MYT1	4661	broad.mit.edu	37	20	62839761	62839761	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:62839761G>A	uc002yii.2	+	7	1576	c.1212G>A	c.(1210-1212)GAG>GAA	p.E404E	MYT1_uc002yih.2_Intron|MYT1_uc002yij.2_Silent_p.E36E	NM_004535	NP_004526	Q01538	MYT1_HUMAN	myelin transcription factor 1	404					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)																	---	---	---	---
MYT1	4661	broad.mit.edu	37	20	62871118	62871118	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:62871118C>A	uc002yii.2	+	22	3463	c.3099C>A	c.(3097-3099)TCC>TCA	p.S1033S	MYT1_uc002yij.2_Silent_p.S692S|MYT1_uc002yik.2_5'UTR	NM_004535	NP_004526	Q01538	MYT1_HUMAN	myelin transcription factor 1	1033					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)																	---	---	---	---
TPTE	7179	broad.mit.edu	37	21	10934035	10934035	+	Intron	SNP	T	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:10934035T>G	uc002yip.1	-						TPTE_uc002yis.1_Intron|TPTE_uc002yiq.1_Intron|TPTE_uc002yir.1_Intron|TPTE_uc010gkv.1_Intron	NM_199261	NP_954870			transmembrane phosphatase with tensin homology						signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)														---	---	---	---
TPTE	7179	broad.mit.edu	37	21	10969127	10969127	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:10969127G>T	uc002yip.1	-	7	489	c.121C>A	c.(121-123)CCA>ACA	p.P41T	TPTE_uc002yis.1_Intron|TPTE_uc002yiq.1_Intron|TPTE_uc002yir.1_Intron|TPTE_uc010gkv.1_Intron	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	41					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)														---	---	---	---
NCAM2	4685	broad.mit.edu	37	21	22664426	22664426	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:22664426C>A	uc002yld.1	+	5	733	c.484C>A	c.(484-486)CGG>AGG	p.R162R	NCAM2_uc011acb.1_Silent_p.R20R|NCAM2_uc011acc.1_Silent_p.R187R	NM_004540	NP_004531	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2 precursor	162	Ig-like C2-type 2.|Extracellular (Potential).				neuron cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)	4		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)														---	---	---	---
APP	351	broad.mit.edu	37	21	27394347	27394347	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:27394347A>G	uc002ylz.2	-	6	874	c.674T>C	c.(673-675)GTA>GCA	p.V225A	APP_uc010glk.2_Missense_Mutation_p.V220A|APP_uc002yma.2_Missense_Mutation_p.V225A|APP_uc011ach.1_Missense_Mutation_p.V169A|APP_uc002ymb.2_Missense_Mutation_p.V225A|APP_uc010glj.2_Missense_Mutation_p.V169A|APP_uc011aci.1_Missense_Mutation_p.V190A|APP_uc011acj.1_Missense_Mutation_p.V225A	NM_000484	NP_000475	P05067	A4_HUMAN	amyloid beta A4 protein isoform a precursor	225	Extracellular (Potential).				adult locomotory behavior|axon cargo transport|axon midline choice point recognition|cell adhesion|cellular copper ion homeostasis|collateral sprouting in absence of injury|dendrite development|endocytosis|extracellular matrix organization|G2 phase of mitotic cell cycle|innate immune response|ionotropic glutamate receptor signaling pathway|mating behavior|mRNA polyadenylation|neuron apoptosis|neuron remodeling|Notch signaling pathway|platelet activation|platelet degranulation|positive regulation of mitotic cell cycle|protein phosphorylation|regulation of epidermal growth factor receptor activity|regulation of multicellular organism growth|regulation of synapse structure and activity|regulation of translation|visual learning	axon|cell surface|coated pit|dendritic shaft|dendritic spine|extracellular region|Golgi apparatus|integral to plasma membrane|platelet alpha granule lumen	acetylcholine receptor binding|DNA binding|heparin binding|identical protein binding|metal ion binding|protein binding|protein binding|PTB domain binding|serine-type endopeptidase inhibitor activity			ovary(1)	1		Breast(209;0.00295)																---	---	---	---
CLDN17	26285	broad.mit.edu	37	21	31538742	31538742	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:31538742T>C	uc011acv.1	-	1	194	c.194A>G	c.(193-195)AAG>AGG	p.K65R		NM_012131	NP_036263	P56750	CLD17_HUMAN	claudin 17	65	Extracellular (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	Golgi apparatus|integral to membrane|tight junction	identical protein binding|structural molecule activity			ovary(2)	2																		---	---	---	---
KRTAP13-2	337959	broad.mit.edu	37	21	31744414	31744414	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:31744414G>T	uc002ynz.3	-	1	144	c.118C>A	c.(118-120)CTC>ATC	p.L40I		NM_181621	NP_853652	Q52LG2	KR132_HUMAN	keratin associated protein 13-2	40						intermediate filament					0																		---	---	---	---
SYNJ1	8867	broad.mit.edu	37	21	34003306	34003306	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:34003306T>C	uc002yqh.2	-	32	4838	c.4838A>G	c.(4837-4839)TAA>TGA	p.*1613*	SYNJ1_uc011ads.1_3'UTR|SYNJ1_uc002yqf.2_3'UTR|SYNJ1_uc002yqg.2_Silent_p.*1527*|SYNJ1_uc002yqi.2_3'UTR|SYNJ1_uc002yqe.3_Silent_p.*199*	NM_003895	NP_003886	O43426	SYNJ1_HUMAN	synaptojanin 1 isoform a	1613							inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			ovary(4)|skin(1)	5																		---	---	---	---
SYNJ1	8867	broad.mit.edu	37	21	34045776	34045776	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:34045776G>A	uc002yqh.2	-	14	1717	c.1717C>T	c.(1717-1719)CGA>TGA	p.R573*	SYNJ1_uc011ads.1_Nonsense_Mutation_p.R529*|SYNJ1_uc002yqf.2_Nonsense_Mutation_p.R534*|SYNJ1_uc002yqg.2_Nonsense_Mutation_p.R529*|SYNJ1_uc002yqi.2_Nonsense_Mutation_p.R573*	NM_003895	NP_003886	O43426	SYNJ1_HUMAN	synaptojanin 1 isoform a	534	Catalytic (Potential).						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			ovary(4)|skin(1)	5																		---	---	---	---
PRDM15	63977	broad.mit.edu	37	21	43248570	43248570	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:43248570A>G	uc002yzq.1	-	19	2695	c.2584T>C	c.(2584-2586)TTC>CTC	p.F862L	PRDM15_uc002yzo.2_Missense_Mutation_p.F533L|PRDM15_uc002yzp.2_Missense_Mutation_p.F553L|PRDM15_uc002yzr.1_Missense_Mutation_p.F553L	NM_022115	NP_071398	P57071	PRD15_HUMAN	PR domain containing 15 isoform 1	862	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
ZNF295	49854	broad.mit.edu	37	21	43411232	43411232	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:43411232T>C	uc002zab.3	-	3	3187	c.2973A>G	c.(2971-2973)CCA>CCG	p.P991P	ZNF295_uc002yzz.3_Silent_p.P790P|ZNF295_uc002yzy.3_Silent_p.P991P|ZNF295_uc002zaa.3_Silent_p.P991P	NM_001098402	NP_001091872	Q9ULJ3	ZN295_HUMAN	zinc finger protein 295 isoform L	991					negative regulation of transcription, DNA-dependent|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|nucleus	methyl-CpG binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3																		---	---	---	---
CBS	875	broad.mit.edu	37	21	44486452	44486452	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:44486452C>T	uc002zcu.2	-	5	597	c.352G>A	c.(352-354)GTG>ATG	p.V118M	CBS_uc002zcs.1_Missense_Mutation_p.V13M|CBS_uc002zct.2_Missense_Mutation_p.V118M|CBS_uc002zcw.3_Missense_Mutation_p.V118M|CBS_uc002zcv.2_Missense_Mutation_p.V118M	NM_000071	NP_000062	P35520	CBS_HUMAN	cystathionine-beta-synthase	118					cysteine biosynthetic process from serine|cysteine biosynthetic process via cystathionine|homocysteine catabolic process|hydrogen sulfide biosynthetic process|L-cysteine catabolic process|L-serine catabolic process	cytosol|nucleolus	cystathionine beta-synthase activity|heme binding|protein homodimerization activity|pyridoxal phosphate binding|ubiquitin protein ligase binding				0					L-Cysteine(DB00151)|L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)|S-Adenosylmethionine(DB00118)													---	---	---	---
PDXK	8566	broad.mit.edu	37	21	45163612	45163612	+	Silent	SNP	G	A	A	rs144786200		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:45163612G>A	uc002zdm.3	+	4	453	c.255G>A	c.(253-255)ACG>ACA	p.T85T	PDXK_uc010gpj.2_Silent_p.T85T|PDXK_uc002zdn.3_Intron|PDXK_uc002zdq.3_Silent_p.T12T	NM_003681	NP_003672	O00764	PDXK_HUMAN	pyridoxal kinase	85					cell proliferation|pyridoxal 5'-phosphate salvage	cytosol	ATP binding|lithium ion binding|magnesium ion binding|potassium ion binding|protein homodimerization activity|pyridoxal kinase activity|pyridoxal phosphate binding|sodium ion binding|zinc ion binding				0				Colorectal(79;0.109)|READ - Rectum adenocarcinoma(84;0.161)|STAD - Stomach adenocarcinoma(101;0.18)	Pyridoxal(DB00147)|Pyridoxine(DB00165)													---	---	---	---
AGPAT3	56894	broad.mit.edu	37	21	45401009	45401009	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:45401009G>A	uc002zdv.2	+	9	1205	c.983G>A	c.(982-984)GGC>GAC	p.G328D	AGPAT3_uc002zdw.2_Missense_Mutation_p.G328D|AGPAT3_uc002zdx.2_Missense_Mutation_p.G415D|AGPAT3_uc002zdy.2_Missense_Mutation_p.G266D	NM_020132	NP_064517	Q9NRZ7	PLCC_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 3	328	Helical; (Potential).				phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	1-acylglycerol-3-phosphate O-acyltransferase activity				0				STAD - Stomach adenocarcinoma(101;0.18)|Colorectal(79;0.24)														---	---	---	---
PWP2	5822	broad.mit.edu	37	21	45540963	45540963	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:45540963C>T	uc002zeb.2	+	13	1706	c.1616C>T	c.(1615-1617)ACG>ATG	p.T539M		NM_005049	NP_005040	Q15269	PWP2_HUMAN	PWP2 periodic tryptophan protein homolog	539						cytoplasm|nucleolus	signal transducer activity			pancreas(1)	1				STAD - Stomach adenocarcinoma(101;0.172)|Colorectal(79;0.2)														---	---	---	---
C21orf29	54084	broad.mit.edu	37	21	45941887	45941887	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:45941887A>G	uc002zfe.1	-	9	1511	c.1445T>C	c.(1444-1446)TTC>TCC	p.F482S	C21orf29_uc010gpv.1_Missense_Mutation_p.F414S	NM_144991	NP_659428	Q8WU66	TSEAR_HUMAN	chromosome 21 open reading frame 29 precursor	482	EAR 4.				cell adhesion	extracellular region	structural molecule activity				0																		---	---	---	---
SUMO3	6612	broad.mit.edu	37	21	46228957	46228957	+	Intron	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:46228957C>T	uc002zfz.1	-						SUMO3_uc011afi.1_Intron|SUMO3_uc002zga.1_Missense_Mutation_p.R76Q	NM_006936	NP_008867			small ubiquitin-like modifier protein 3						protein sumoylation	cytoplasm|kinetochore	protein binding				0				Colorectal(79;0.058)														---	---	---	---
MCM3AP	8888	broad.mit.edu	37	21	47695152	47695152	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:47695152C>T	uc002zir.1	-	6	1982	c.1946G>A	c.(1945-1947)CGG>CAG	p.R649Q		NM_003906	NP_003897	O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3	649					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			large_intestine(2)|lung(1)|ovary(1)|skin(1)	5	Breast(49;0.112)																	---	---	---	---
CECR2	27443	broad.mit.edu	37	22	18022149	18022149	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:18022149G>A	uc010gqw.1	+	15	2377	c.2251G>A	c.(2251-2253)GTC>ATC	p.V751I	CECR2_uc010gqv.1_Missense_Mutation_p.V610I|CECR2_uc002zml.2_Missense_Mutation_p.V610I	NM_031413	NP_113601	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	793					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			ovary(1)|skin(1)	2		all_epithelial(15;0.139)		Lung(27;0.146)														---	---	---	---
BCL2L13	23786	broad.mit.edu	37	22	18209837	18209837	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:18209837G>T	uc002zmw.2	+	7	1213	c.995G>T	c.(994-996)CGG>CTG	p.R332L	BCL2L13_uc002zmx.2_Missense_Mutation_p.R170L|BCL2L13_uc002zmy.2_3'UTR|BCL2L13_uc010gqy.2_Missense_Mutation_p.R170L|BCL2L13_uc011agk.1_Missense_Mutation_p.R208L|BCL2L13_uc010gqz.2_Missense_Mutation_p.R52L|BCL2L13_uc002zmz.2_Missense_Mutation_p.R170L|BCL2L13_uc002zna.2_Missense_Mutation_p.R52L	NM_015367	NP_056182	Q9BXK5	B2L13_HUMAN	BCL2-like 13 (apoptosis facilitator)	332	Glu-rich.				induction of apoptosis	integral to membrane|mitochondrial membrane|nucleus	caspase activator activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4		all_epithelial(15;0.123)		Lung(27;0.199)														---	---	---	---
MICAL3	57553	broad.mit.edu	37	22	18347700	18347700	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:18347700G>A	uc002zng.3	-	19	2923	c.2570C>T	c.(2569-2571)GCC>GTC	p.A857V	MICAL3_uc011agl.1_Missense_Mutation_p.A857V|MICAL3_uc002znh.2_Missense_Mutation_p.A857V|MICAL3_uc002znj.1_Missense_Mutation_p.A585V|MICAL3_uc002znk.1_Missense_Mutation_p.A857V|MICAL3_uc002znl.1_Missense_Mutation_p.A490V|MICAL3_uc002znm.2_Missense_Mutation_p.A358V|MICAL3_uc010grf.2_Missense_Mutation_p.A981V	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	microtubule associated monoxygenase, calponin	857						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding				0		all_epithelial(15;0.198)		Lung(27;0.0427)														---	---	---	---
TUBA8	51807	broad.mit.edu	37	22	18604328	18604328	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:18604328G>A	uc002znv.1	+	2	159	c.86G>A	c.(85-87)GGC>GAC	p.G29D	TUBA8_uc002znr.2_5'UTR|TUBA8_uc002znw.1_Missense_Mutation_p.G53D|TUBA8_uc002znu.1_Missense_Mutation_p.G29D	NM_018943	NP_061816	Q9NY65	TBA8_HUMAN	tubulin, alpha 8	29					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity				0																		---	---	---	---
CLTCL1	8218	broad.mit.edu	37	22	19197931	19197931	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:19197931C>T	uc002zpb.2	-	20	3229	c.3154G>A	c.(3154-3156)GCA>ACA	p.A1052T	CLTCL1_uc011agv.1_Missense_Mutation_p.A1052T|CLTCL1_uc011agw.1_Missense_Mutation_p.A1052T|CLTCL1_uc011agt.1_5'Flank|CLTCL1_uc011agu.1_5'Flank|CLTCL1_uc010grm.1_5'Flank|CLTCL1_uc002zpe.2_Missense_Mutation_p.A12T|CLTCL1_uc002zpd.1_Missense_Mutation_p.A12T	NM_007098	NP_009029	P53675	CLH2_HUMAN	clathrin, heavy polypeptide-like 1 isoform 1	1052	Proximal segment.|Heavy chain arm.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			ovary(4)|central_nervous_system(1)	5	Colorectal(54;0.0993)							T	?	ALCL								---	---	---	---
PI4KA	5297	broad.mit.edu	37	22	21064220	21064220	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:21064220C>T	uc002zsz.3	-	53	6206	c.5975G>A	c.(5974-5976)CGC>CAC	p.R1992H	PI4KA_uc010gsp.2_Missense_Mutation_p.R383H|PI4KA_uc002zsy.3_Missense_Mutation_p.R802H	NM_058004	NP_477352	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase type 3 alpha	1992	PI3K/PI4K.				phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			lung(2)|upper_aerodigestive_tract(1)|salivary_gland(1)	4	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)															---	---	---	---
LZTR1	8216	broad.mit.edu	37	22	21342386	21342386	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:21342386C>T	uc002zto.2	+	5	591	c.488C>T	c.(487-489)ACG>ATG	p.T163M	LZTR1_uc002ztn.2_Missense_Mutation_p.T122M|LZTR1_uc011ahy.1_Missense_Mutation_p.T144M|LZTR1_uc010gsr.1_Missense_Mutation_p.T34M	NM_006767	NP_006758	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	163	Kelch 2.				anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			ovary(2)|lung(2)	4	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)															---	---	---	---
CCDC116	164592	broad.mit.edu	37	22	21989291	21989291	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:21989291G>A	uc002zve.2	+	4	1032	c.939G>A	c.(937-939)CTG>CTA	p.L313L	CCDC116_uc011aih.1_Silent_p.L313L	NM_152612	NP_689825	Q8IYX3	CC116_HUMAN	coiled-coil domain containing 116	313										ovary(1)|skin(1)	2	Colorectal(54;0.105)																	---	---	---	---
PPIL2	23759	broad.mit.edu	37	22	22025326	22025326	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:22025326G>A	uc010gtj.1	+	4	285	c.169G>A	c.(169-171)GAT>AAT	p.D57N	PPIL2_uc002zvh.3_Missense_Mutation_p.D57N|PPIL2_uc002zvi.3_Missense_Mutation_p.D57N|PPIL2_uc002zvg.3_Missense_Mutation_p.D57N|PPIL2_uc011aij.1_Intron	NM_148175	NP_680480	Q13356	PPIL2_HUMAN	peptidylprolyl isomerase-like 2 isoform a	57	U-box.				blood coagulation|leukocyte migration|protein folding|protein polyubiquitination	Golgi lumen|nucleus|ubiquitin ligase complex	peptidyl-prolyl cis-trans isomerase activity|ubiquitin-ubiquitin ligase activity			ovary(2)	2	Colorectal(54;0.105)																	---	---	---	---
LOC96610	96610	broad.mit.edu	37	22	22569487	22569487	+	Intron	SNP	A	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:22569487A>C	uc011aim.1	+						uc011aio.1_RNA					Parts of antibodies, mostly variable regions.												0																		---	---	---	---
LOC96610	96610	broad.mit.edu	37	22	23090366	23090366	+	RNA	SNP	C	T	T	rs7285911		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:23090366C>T	uc011aim.1	+	203		c.10660C>T								Parts of antibodies, mostly variable regions.												0																		---	---	---	---
BCR	613	broad.mit.edu	37	22	23615329	23615329	+	Intron	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:23615329C>T	uc002zww.2	+						BCR_uc002zwx.2_Intron|BCR_uc011aiy.1_Intron|BCR_uc010gtx.1_Intron	NM_004327	NP_004318			breakpoint cluster region isoform 1						regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	ATP binding|GTPase activator activity|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity		BCR/JAK2(6)	haematopoietic_and_lymphoid_tissue(6)|central_nervous_system(3)|urinary_tract(1)|lung(1)|skin(1)	12								T	ABL1| FGFR1|JAK2 	CML|ALL|AML								---	---	---	---
SUSD2	56241	broad.mit.edu	37	22	24579170	24579170	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:24579170C>T	uc002zzn.1	+	2	266	c.222C>T	c.(220-222)GGC>GGT	p.G74G		NM_019601	NP_062547	Q9UGT4	SUSD2_HUMAN	sushi domain containing 2 precursor	74	Extracellular (Potential).				immune response	integral to membrane	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1																		---	---	---	---
C22orf36	388886	broad.mit.edu	37	22	24981946	24981946	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:24981946C>A	uc003aaq.2	-	4	885	c.856G>T	c.(856-858)GGC>TGC	p.G286C	GGT1_uc003aan.1_Intron|C22orf36_uc003aao.2_RNA|C22orf36_uc003aap.2_RNA	NM_207644	NP_997527	Q2VPJ9	LRC6X_HUMAN	hypothetical protein LOC388886	286											0																		---	---	---	---
PIWIL3	440822	broad.mit.edu	37	22	25150758	25150758	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:25150758G>A	uc003abd.1	-	7	1183	c.766C>T	c.(766-768)CGT>TGT	p.R256C	PIWIL3_uc011ajx.1_Missense_Mutation_p.R147C|PIWIL3_uc011ajy.1_Missense_Mutation_p.R147C|PIWIL3_uc010gut.1_Missense_Mutation_p.R256C	NM_001008496	NP_001008496	Q7Z3Z3	PIWL3_HUMAN	piwi-like 3	256					cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			ovary(3)|central_nervous_system(1)	4																		---	---	---	---
MYO18B	84700	broad.mit.edu	37	22	26423476	26423476	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:26423476C>T	uc003abz.1	+	43	7786	c.7536C>T	c.(7534-7536)TCC>TCT	p.S2512S	MYO18B_uc003aca.1_Silent_p.S2393S|MYO18B_uc010guy.1_Silent_p.S2394S|MYO18B_uc010guz.1_Silent_p.S2392S|MYO18B_uc011aka.1_Silent_p.S1666S|MYO18B_uc011akb.1_Silent_p.S2025S|MYO18B_uc010gva.1_Silent_p.S495S|MYO18B_uc010gvb.1_RNA	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2512	Poly-Ser.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12																		---	---	---	---
KREMEN1	83999	broad.mit.edu	37	22	29490351	29490351	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:29490351A>G	uc011akm.1	+	2	216	c.203A>G	c.(202-204)TAC>TGC	p.Y68C	KREMEN1_uc003ael.2_Missense_Mutation_p.Y68C|KREMEN1_uc011akn.1_Translation_Start_Site	NM_032045	NP_114434	Q96MU8	KREM1_HUMAN	kringle-containing transmembrane protein 1	66	Extracellular (Potential).|Kringle.				cell communication|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane|membrane fraction	protein binding			ovary(3)|lung(2)	5																		---	---	---	---
THOC5	8563	broad.mit.edu	37	22	29913074	29913074	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:29913074G>A	uc003afr.2	-	18	1960	c.1625C>T	c.(1624-1626)GCG>GTG	p.A542V	THOC5_uc003afq.2_Missense_Mutation_p.A203V|THOC5_uc003afs.2_Missense_Mutation_p.A542V|THOC5_uc003aft.2_Missense_Mutation_p.A542V|THOC5_uc003afu.2_Missense_Mutation_p.A542V|THOC5_uc010gvo.2_Missense_Mutation_p.A286V	NM_001002878	NP_001002878	Q13769	THOC5_HUMAN	THO complex 5	542					intronless viral mRNA export from host nucleus|monocyte differentiation|mRNA processing|primitive hemopoiesis|RNA splicing	cytoplasm|intermediate filament cytoskeleton|THO complex part of transcription export complex	protein binding|RNA binding			breast(3)	3																		---	---	---	---
MTMR3	8897	broad.mit.edu	37	22	30412615	30412615	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:30412615T>C	uc003agv.3	+	15	1930	c.1602T>C	c.(1600-1602)TGT>TGC	p.C534C	MTMR3_uc003agu.3_Silent_p.C534C|MTMR3_uc003agw.3_Silent_p.C534C	NM_021090	NP_066576	Q13615	MTMR3_HUMAN	myotubularin-related protein 3 isoform c	534	Myotubularin phosphatase.				phosphatidylinositol dephosphorylation	cytoplasm|membrane|membrane fraction|nucleus	metal ion binding|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(3)|ovary(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(5;0.00204)|Epithelial(10;0.06)|all cancers(5;0.107)															---	---	---	---
LIF	3976	broad.mit.edu	37	22	30640888	30640888	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:30640888T>C	uc003agz.2	-	2	166	c.54A>G	c.(52-54)AAA>AAG	p.K18K	LIF_uc011aks.1_Intron|uc003aha.2_5'Flank	NM_002309	NP_002300	P15018	LIF_HUMAN	leukemia inhibitory factor (cholinergic	18					immune response|leukemia inhibitory factor signaling pathway|negative regulation of hormone secretion|positive regulation of cell proliferation|positive regulation of macrophage differentiation|positive regulation of MAPKKK cascade|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of peptidyl-serine phosphorylation of STAT protein|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of metanephric nephron tubule epithelial cell differentiation		cytokine activity|growth factor activity|leukemia inhibitory factor receptor binding				0			Epithelial(10;0.171)															---	---	---	---
DUSP18	150290	broad.mit.edu	37	22	31059826	31059826	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:31059826C>A	uc003aiu.2	-	2	666	c.165G>T	c.(163-165)GAG>GAT	p.E55D	SLC35E4_uc003ait.2_Intron|DUSP18_uc010gwa.1_RNA|DUSP18_uc003aiw.1_Missense_Mutation_p.E55D	NM_152511	NP_689724	Q8NEJ0	DUS18_HUMAN	dual specificity phosphatase 18	55						cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0																		---	---	---	---
LIMK2	3985	broad.mit.edu	37	22	31671133	31671133	+	Intron	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:31671133A>G	uc003akh.2	+						LIMK2_uc003akg.2_Intron|LIMK2_uc003aki.2_Intron|LIMK2_uc003akj.2_Intron|LIMK2_uc003akk.2_Intron|LIMK2_uc011aln.1_Intron	NM_005569	NP_005560			LIM domain kinase 2 isoform 2a							mitochondrion|nucleus	ATP binding|protein serine/threonine kinase activity|zinc ion binding			ovary(2)	2																		---	---	---	---
PATZ1	23598	broad.mit.edu	37	22	31737553	31737553	+	Intron	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:31737553G>A	uc003akq.2	-						PATZ1_uc003akp.2_Intron|PATZ1_uc003akr.2_Intron|PATZ1_uc003aks.2_Silent_p.T484T	NM_014323	NP_055138			POZ (BTB) and AT hook containing zinc finger 1						negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/PATZ1(2)	soft_tissue(2)	2																		---	---	---	---
PISD	23761	broad.mit.edu	37	22	32021813	32021813	+	Intron	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:32021813G>T	uc003alm.3	-						PISD_uc003alk.2_Translation_Start_Site|PISD_uc003all.2_Translation_Start_Site|PISD_uc011alr.1_Translation_Start_Site|PISD_uc003aln.3_Intron	NM_014338	NP_055153			phosphatidylserine decarboxylase						phospholipid biosynthetic process	mitochondrion	phosphatidylserine decarboxylase activity			central_nervous_system(2)|ovary(1)	3					Phosphatidylserine(DB00144)													---	---	---	---
CARD10	29775	broad.mit.edu	37	22	37914037	37914037	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:37914037G>T	uc003asx.1	-	2	317	c.314C>A	c.(313-315)CCC>CAC	p.P105H	CARD10_uc003ast.1_RNA|CARD10_uc003asy.1_Missense_Mutation_p.P105H	NM_014550	NP_055365	Q9BWT7	CAR10_HUMAN	caspase recruitment domain protein 10	105	CARD.				activation of NF-kappaB-inducing kinase activity|protein complex assembly|regulation of apoptosis	CBM complex	receptor signaling complex scaffold activity			upper_aerodigestive_tract(1)|lung(1)|breast(1)|ovary(1)|prostate(1)|kidney(1)	6	Melanoma(58;0.0574)																	---	---	---	---
SOX10	6663	broad.mit.edu	37	22	38369825	38369825	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:38369825T>C	uc003aun.1	-	4	1356	c.1078A>G	c.(1078-1080)ACC>GCC	p.T360A	POLR2F_uc003aum.2_Intron|SOX10_uc003auo.1_Missense_Mutation_p.T360A	NM_006941	NP_008872	P56693	SOX10_HUMAN	SRY (sex determining region Y)-box 10	360						cytoplasm|nucleus	DNA binding|identical protein binding|transcription coactivator activity				0	Melanoma(58;0.045)																	---	---	---	---
TMEM184B	25829	broad.mit.edu	37	22	38621482	38621482	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:38621482C>T	uc003avf.1	-	7	960	c.736G>A	c.(736-738)GTC>ATC	p.V246I	TMEM184B_uc003avg.1_Missense_Mutation_p.V246I|TMEM184B_uc003avh.1_Missense_Mutation_p.V180I|TMEM184B_uc010gxl.1_RNA	NM_012264	NP_036396	Q9Y519	T184B_HUMAN	transmembrane protein 184B	246						integral to membrane					0	Melanoma(58;0.045)																	---	---	---	---
CBX6	23466	broad.mit.edu	37	22	39262317	39262317	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:39262317G>A	uc003awl.2	-	5	1199	c.1136C>T	c.(1135-1137)ACG>ATG	p.T379M		NM_014292	NP_055107	O95503	CBX6_HUMAN	chromobox homolog 6	379					chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	PcG protein complex					0	Melanoma(58;0.04)																	---	---	---	---
TAB1	10454	broad.mit.edu	37	22	39772162	39772162	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:39772162G>A	uc003axr.2	+	2	2003	c.221G>A	c.(220-222)CGG>CAG	p.R74Q	SYNGR1_uc003axo.3_Missense_Mutation_p.R148Q|SYNGR1_uc003axp.3_Silent_p.P114P|SYNGR1_uc003axq.3_Missense_Mutation_p.R148Q|SYNGR1_uc003axs.3_Missense_Mutation_p.R149Q	NM_006116	NP_006107	Q15750	TAB1_HUMAN	mitogen-activated protein kinase kinase kinase 7	Error:Variant_position_missing_in_Q15750_after_alignment					activation of MAPK activity|activation of MAPKKK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane	catalytic activity|protein binding			breast(1)	1																		---	---	---	---
CACNA1I	8911	broad.mit.edu	37	22	40064344	40064344	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:40064344C>T	uc003ayc.2	+	24	4152	c.4152C>T	c.(4150-4152)AAC>AAT	p.N1384N	CACNA1I_uc003ayd.2_Silent_p.N1349N|CACNA1I_uc003aye.2_Silent_p.N1299N|CACNA1I_uc003ayf.2_Silent_p.N1264N	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	1384	Extracellular (Potential).|III.				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)													---	---	---	---
EP300	2033	broad.mit.edu	37	22	41574817	41574817	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:41574817G>A	uc003azl.3	+	31	7497	c.7102G>A	c.(7102-7104)GAC>AAC	p.D2368N		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	2368					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64								T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				---	---	---	---
PPARA	5465	broad.mit.edu	37	22	46611162	46611162	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:46611162G>A	uc003bgw.1	+	5	567	c.301G>A	c.(301-303)GAA>AAA	p.E101K	PPARA_uc003bgx.1_Missense_Mutation_p.E101K|PPARA_uc010hab.1_Missense_Mutation_p.E101K|PPARA_uc003bha.2_Missense_Mutation_p.E101K|PPARA_uc003bhb.1_Missense_Mutation_p.E101K|PPARA_uc010hac.1_5'UTR	NM_005036	NP_005027	Q07869	PPARA_HUMAN	peroxisome proliferative activated receptor,	101	Nuclear receptor.				fatty acid metabolic process|fatty acid transport|negative regulation of appetite|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fatty acid beta-oxidation|regulation of cellular ketone metabolic process by positive regulation of transcription from an RNA polymerase II promoter|regulation of glycolysis by positive regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|ligand-regulated transcription factor activity|lipid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|ubiquitin conjugating enzyme binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00522)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Clofibrate(DB00636)|Fenofibrate(DB01039)|Gemfibrozil(DB01241)|Simvastatin(DB00641)													---	---	---	---
CELSR1	9620	broad.mit.edu	37	22	46780469	46780469	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:46780469G>A	uc003bhw.1	-	20	6854	c.6854C>T	c.(6853-6855)GCC>GTC	p.A2285V	CELSR1_uc011arc.1_Missense_Mutation_p.A606V	NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	2285	Extracellular (Potential).				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)														---	---	---	---
SELO	83642	broad.mit.edu	37	22	50647139	50647139	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:50647139C>T	uc011arr.1	+	3	991	c.933C>T	c.(931-933)TTC>TTT	p.F311F	SELO_uc010hap.2_Silent_p.F122F|SELO_uc003bjy.2_5'UTR|SELO_uc003bjz.2_5'Flank	NM_031454	NP_113642	Q9BVL4	SELO_HUMAN	selenoprotein O	311											0		all_cancers(38;1.14e-10)|all_epithelial(38;2.12e-09)|all_lung(38;7.01e-05)|Breast(42;0.000523)|Lung NSC(38;0.0018)|Ovarian(80;0.0365)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.105)														---	---	---	---
TUBGCP6	85378	broad.mit.edu	37	22	50682331	50682331	+	Silent	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:50682331T>C	uc003bkb.1	-	1	1070	c.558A>G	c.(556-558)CCA>CCG	p.P186P	TUBGCP6_uc010har.1_Silent_p.P186P|TUBGCP6_uc010has.1_RNA|TUBGCP6_uc010hau.1_Silent_p.P186P	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	186					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)														---	---	---	---
PLXNB2	23654	broad.mit.edu	37	22	50720088	50720088	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:50720088C>A	uc003bkv.3	-	21	3535	c.3429G>T	c.(3427-3429)ACG>ACT	p.T1143T	PLXNB2_uc003bkt.1_5'UTR|PLXNB2_uc003bku.1_Silent_p.T128T	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	1143	Extracellular (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)														---	---	---	---
SAPS2	9701	broad.mit.edu	37	22	50869710	50869710	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:50869710G>A	uc003blb.1	+	12	1656	c.1234G>A	c.(1234-1236)GGA>AGA	p.G412R	SAPS2_uc003bky.1_Missense_Mutation_p.G412R|SAPS2_uc003bkz.1_Missense_Mutation_p.G412R|SAPS2_uc003blc.2_Missense_Mutation_p.G412R|SAPS2_uc003bla.1_Missense_Mutation_p.G413R|SAPS2_uc003bld.1_5'UTR	NM_014678	NP_055493	O75170	PP6R2_HUMAN	SAPS domain family, member 2	412						cytoplasm|intracellular membrane-bounded organelle	protein binding				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.222)														---	---	---	---
MIOX	55586	broad.mit.edu	37	22	50927589	50927589	+	Intron	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:50927589C>T	uc003bll.1	+						MIOX_uc003blm.1_Intron|MIOX_uc003bln.1_Intron	NM_017584	NP_060054			myo-inositol oxygenase						inositol catabolic process	cytoplasm|inclusion body	aldo-keto reductase (NADP) activity|ferric iron binding|inositol oxygenase activity				0		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)														---	---	---	---
KLHDC7B	113730	broad.mit.edu	37	22	50987578	50987578	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:50987578G>A	uc003bmi.2	+	1	1117	c.983G>A	c.(982-984)CGG>CAG	p.R328Q		NM_138433	NP_612442	Q96G42	KLD7B_HUMAN	kelch domain containing 7B	328	Kelch 1.									central_nervous_system(1)	1		all_cancers(38;1.53e-10)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		OV - Ovarian serous cystadenocarcinoma(4;7.49e-69)|all cancers(3;9.79e-66)|Epithelial(4;1.3e-63)|GBM - Glioblastoma multiforme(4;0.000399)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)														---	---	---	---
KLHDC7B	113730	broad.mit.edu	37	22	50987635	50987635	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:50987635G>A	uc003bmi.2	+	1	1174	c.1040G>A	c.(1039-1041)TGC>TAC	p.C347Y		NM_138433	NP_612442	Q96G42	KLD7B_HUMAN	kelch domain containing 7B	347	Kelch 1.									central_nervous_system(1)	1		all_cancers(38;1.53e-10)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		OV - Ovarian serous cystadenocarcinoma(4;7.49e-69)|all cancers(3;9.79e-66)|Epithelial(4;1.3e-63)|GBM - Glioblastoma multiforme(4;0.000399)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)														---	---	---	---
CSF2RA	1438	broad.mit.edu	37	X	1407744	1407744	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:1407744C>A	uc010nct.2	+	7	758	c.436C>A	c.(436-438)CGT>AGT	p.R146S	CSF2RA_uc011mhb.1_Missense_Mutation_p.R146S|CSF2RA_uc004cpq.2_Missense_Mutation_p.R146S|CSF2RA_uc004cpn.2_Missense_Mutation_p.R146S|CSF2RA_uc004cpo.2_Missense_Mutation_p.R146S|CSF2RA_uc010ncu.2_RNA|CSF2RA_uc011mhc.1_Missense_Mutation_p.R13S|CSF2RA_uc004cpp.2_Missense_Mutation_p.R146S|CSF2RA_uc010ncv.2_Missense_Mutation_p.R146S|CSF2RA_uc004cpr.2_Missense_Mutation_p.R146S	NM_001161529	NP_001155001	P15509	CSF2R_HUMAN	colony stimulating factor 2 receptor alpha chain	146	Extracellular (Potential).					extracellular region|integral to plasma membrane	cytokine receptor activity	p.R146H(1)		ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)													---	---	---	---
IL3RA	3563	broad.mit.edu	37	X	1467396	1467396	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:1467396G>A	uc004cps.2	+	4	605	c.256G>A	c.(256-258)GCC>ACC	p.A86T	IL3RA_uc011mhd.1_Intron	NM_002183	NP_002174	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha precursor	86	Extracellular (Potential).					integral to membrane|plasma membrane	interleukin-3 receptor activity			skin(2)|lung(1)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)													---	---	---	---
ASMTL	8623	broad.mit.edu	37	X	1546952	1546952	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:1546952C>T	uc004cpx.1	-	7	683	c.572G>A	c.(571-573)GGG>GAG	p.G191E	ASMTL_uc011mhe.1_Missense_Mutation_p.G115E|ASMTL_uc004cpy.1_Missense_Mutation_p.G175E|ASMTL_uc011mhf.1_Missense_Mutation_p.G133E	NM_004192	NP_004183	O95671	ASML_HUMAN	acetylserotonin O-methyltransferase-like	191	MAF-like.				melatonin biosynthetic process	cytoplasm	acetylserotonin O-methyltransferase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)																---	---	---	---
ASMTL	8623	broad.mit.edu	37	X	1561150	1561150	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:1561150C>T	uc004cpx.1	-	2	265	c.154G>A	c.(154-156)GCT>ACT	p.A52T	ASMTL_uc011mhe.1_5'UTR|ASMTL_uc004cpy.1_Missense_Mutation_p.A52T|ASMTL_uc011mhf.1_5'UTR	NM_004192	NP_004183	O95671	ASML_HUMAN	acetylserotonin O-methyltransferase-like	52	MAF-like.				melatonin biosynthetic process	cytoplasm	acetylserotonin O-methyltransferase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)																---	---	---	---
DHRSX	207063	broad.mit.edu	37	X	2343345	2343345	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:2343345A>G	uc004cqf.3	-	2	159	c.110T>C	c.(109-111)GTT>GCT	p.V37A		NM_145177	NP_660160	Q8N5I4	DHRSX_HUMAN	dehydrogenase/reductase (SDR family) X-linked	37							binding|oxidoreductase activity				0		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)																---	---	---	---
MXRA5	25878	broad.mit.edu	37	X	3248316	3248316	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:3248316G>A	uc004crg.3	-	4	609	c.452C>T	c.(451-453)ACG>ATG	p.T151M		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	151						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)																---	---	---	---
WWC3	55841	broad.mit.edu	37	X	10062324	10062324	+	Intron	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:10062324A>G	uc004csx.3	+						WWC3_uc010nds.2_Intron|WWC3_uc010ndt.2_Intron	NM_015691	NP_056506			WWC family member 3											ovary(4)	4																		---	---	---	---
PHKA2	5256	broad.mit.edu	37	X	18944655	18944655	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:18944655C>A	uc004cyv.3	-	14	1805	c.1375G>T	c.(1375-1377)GGG>TGG	p.G459W	PHKA2_uc010nfg.1_RNA	NM_000292	NP_000283	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	459					glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(1)|central_nervous_system(1)	2	Hepatocellular(33;0.183)																	---	---	---	---
PDHA1	5160	broad.mit.edu	37	X	19373631	19373631	+	Intron	SNP	A	G	G	rs2643456		TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:19373631A>G	uc004czg.3	+						PDHA1_uc004czh.3_Intron|PDHA1_uc011mjc.1_Intron|PDHA1_uc011mjd.1_Intron|PDHA1_uc010nfk.2_Intron|PDHA1_uc010nfl.2_Intron	NM_000284	NP_000275			pyruvate dehydrogenase E1 alpha 1 precursor						glycolysis|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	protein binding|pyruvate dehydrogenase (acetyl-transferring) activity			ovary(1)	1	Hepatocellular(33;0.183)				NADH(DB00157)													---	---	---	---
SH3KBP1	30011	broad.mit.edu	37	X	19705767	19705767	+	Intron	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:19705767G>A	uc004czm.2	-						SH3KBP1_uc004czl.2_Intron	NM_031892	NP_114098			SH3-domain kinase binding protein 1 isoform a						apoptosis|cell-cell signaling|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytoplasmic vesicle membrane|cytoskeleton|cytosol|focal adhesion|nucleus|synapse|synaptosome	SH3 domain binding				0																		---	---	---	---
DCAF8L1	139425	broad.mit.edu	37	X	27999203	27999203	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:27999203G>A	uc004dbx.1	-	1	364	c.249C>T	c.(247-249)AGC>AGT	p.S83S		NM_001017930	NP_001017930	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	83	Glu-rich.									ovary(3)|skin(1)	4																		---	---	---	---
FAM47A	158724	broad.mit.edu	37	X	34150286	34150286	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:34150286C>T	uc004ddg.2	-	1	143	c.110G>A	c.(109-111)CGC>CAC	p.R37H		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	37										ovary(4)|central_nervous_system(1)	5																		---	---	---	---
TMEM47	83604	broad.mit.edu	37	X	34657419	34657419	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:34657419G>A	uc004ddh.2	-	2	571	c.312C>T	c.(310-312)TGC>TGT	p.C104C	TMEM47_uc010ngs.2_RNA	NM_031442	NP_113630	Q9BQJ4	TMM47_HUMAN	transmembrane protein 47	104						integral to membrane				lung(1)	1																		---	---	---	---
BCOR	54880	broad.mit.edu	37	X	39931850	39931850	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:39931850T>C	uc004den.3	-	4	3041	c.2749A>G	c.(2749-2751)ACC>GCC	p.T917A	BCOR_uc004dep.3_Missense_Mutation_p.T917A|BCOR_uc004deo.3_Missense_Mutation_p.T917A|BCOR_uc004dem.3_Missense_Mutation_p.T917A|BCOR_uc004deq.3_Missense_Mutation_p.T917A	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	917					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4																		---	---	---	---
PHF16	9767	broad.mit.edu	37	X	46898473	46898473	+	Intron	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:46898473T>C	uc004dgx.2	+						PHF16_uc004dgy.2_Intron	NM_001077445	NP_001070913			PHD finger protein 16						histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding				0																		---	---	---	---
ARAF	369	broad.mit.edu	37	X	47430395	47430395	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:47430395G>A	uc011mlq.1	+	15	1803	c.1670G>A	c.(1669-1671)CGG>CAG	p.R557Q		NM_001654	NP_001645	P10398	ARAF_HUMAN	v-raf murine sarcoma 3611 viral oncogene	557	Protein kinase.				intracellular signal transduction|negative regulation of apoptosis|positive regulation of peptidyl-serine phosphorylation		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|receptor signaling protein activity			large_intestine(3)|lung(2)|ovary(1)|skin(1)	7					Adenosine triphosphate(DB00171)													---	---	---	---
SLC38A5	92745	broad.mit.edu	37	X	48319469	48319469	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:48319469G>A	uc010nid.2	-	13	1033	c.855C>T	c.(853-855)CCC>CCT	p.P285P	SLC38A5_uc004djk.3_Silent_p.P234P	NM_033518	NP_277053	Q8WUX1	S38A5_HUMAN	solute carrier family 38, member 5	285	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|ion transport	integral to membrane|plasma membrane				ovary(3)	3																		---	---	---	---
TBC1D25	4943	broad.mit.edu	37	X	48417659	48417659	+	Silent	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:48417659C>T	uc004dka.1	+	5	741	c.630C>T	c.(628-630)CAC>CAT	p.H210H	TBC1D25_uc011mly.1_Silent_p.H152H|TBC1D25_uc004dkb.1_Translation_Start_Site|TBC1D25_uc011mlz.1_Translation_Start_Site|TBC1D25_uc011mma.1_Translation_Start_Site|TBC1D25_uc004dkc.1_Translation_Start_Site|TBC1D25_uc011mmb.1_Silent_p.H214H|TBC1D25_uc011mmc.1_Translation_Start_Site|TBC1D25_uc011mmd.1_Translation_Start_Site	NM_002536	NP_002527	Q3MII6	TBC25_HUMAN	TBC1 domain family, member 25	210						intracellular	Rab GTPase activator activity			ovary(1)	1																		---	---	---	---
KDM5C	8242	broad.mit.edu	37	X	53226001	53226001	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:53226001T>C	uc004drz.2	-	19	3381	c.2848A>G	c.(2848-2850)ATG>GTG	p.M950V	KDM5C_uc011moc.1_RNA|KDM5C_uc011mod.1_Missense_Mutation_p.M883V|KDM5C_uc004dsa.2_Missense_Mutation_p.M949V	NM_004187	NP_004178	P41229	KDM5C_HUMAN	jumonji, AT rich interactive domain 1C isoform	950					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			kidney(9)|ovary(5)|salivary_gland(1)|autonomic_ganglia(1)|haematopoietic_and_lymphoid_tissue(1)|oesophagus(1)	18								N|F|S		clear cell renal carcinoma								---	---	---	---
KDM5C	8242	broad.mit.edu	37	X	53230892	53230892	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:53230892C>T	uc004drz.2	-	14	2434	c.1901G>A	c.(1900-1902)CGC>CAC	p.R634H	KDM5C_uc011moc.1_RNA|KDM5C_uc011mod.1_Missense_Mutation_p.R567H|KDM5C_uc004dsa.2_Missense_Mutation_p.R633H	NM_004187	NP_004178	P41229	KDM5C_HUMAN	jumonji, AT rich interactive domain 1C isoform	634	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			kidney(9)|ovary(5)|salivary_gland(1)|autonomic_ganglia(1)|haematopoietic_and_lymphoid_tissue(1)|oesophagus(1)	18								N|F|S		clear cell renal carcinoma								---	---	---	---
SMC1A	8243	broad.mit.edu	37	X	53440338	53440338	+	Silent	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:53440338A>G	uc004dsg.2	-	4	528	c.459T>C	c.(457-459)GCT>GCC	p.A153A	SMC1A_uc011moe.1_Silent_p.A131A|SMC1A_uc011mof.1_Intron|SMC1A_uc004dsi.1_Silent_p.A19A	NM_006306	NP_006297	Q14683	SMC1A_HUMAN	structural maintenance of chromosomes 1A	153					cell cycle checkpoint|cell division|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic sister chromatid cohesion|mitotic spindle organization|negative regulation of DNA endoreduplication|nuclear mRNA splicing, via spliceosome|response to radiation|signal transduction in response to DNA damage	cohesin core heterodimer|condensed chromosome kinetochore|condensed nuclear chromosome|cytoplasm|meiotic cohesin complex|nucleoplasm	ATP binding|chromatin binding|microtubule motor activity|protein heterodimerization activity			ovary(5)|central_nervous_system(1)	6																		---	---	---	---
HUWE1	10075	broad.mit.edu	37	X	53581889	53581889	+	Intron	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:53581889G>A	uc004dsp.2	-						HUWE1_uc004dsn.2_Intron	NM_031407	NP_113584			HECT, UBA and WWE domain containing 1						base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17																		---	---	---	---
WNK3	65267	broad.mit.edu	37	X	54359575	54359575	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:54359575G>C	uc004dtd.1	-	2	971	c.532C>G	c.(532-534)CTG>GTG	p.L178V	WNK3_uc004dtc.1_Missense_Mutation_p.L178V	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	178	Protein kinase.				intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11																		---	---	---	---
FOXR2	139628	broad.mit.edu	37	X	55650330	55650330	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:55650330G>A	uc004duo.2	+	1	498	c.186G>A	c.(184-186)AAG>AAA	p.K62K		NM_198451	NP_940853	Q6PJQ5	FOXR2_HUMAN	forkhead box R2	62					embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			lung(2)|central_nervous_system(1)	3																		---	---	---	---
AWAT2	158835	broad.mit.edu	37	X	69261725	69261725	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:69261725C>T	uc004dxt.1	-	7	941	c.935G>A	c.(934-936)CGT>CAT	p.R312H		NM_001002254	NP_001002254	Q6E213	AWAT2_HUMAN	wax synthase 2	312						endoplasmic reticulum membrane|integral to membrane	long-chain-alcohol O-fatty-acyltransferase activity				0																		---	---	---	---
NLGN3	54413	broad.mit.edu	37	X	70367594	70367594	+	5'UTR	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:70367594C>T	uc004dzd.1	+	1					NLGN3_uc010nlb.1_5'UTR|NLGN3_uc004dzb.2_5'UTR|NLGN3_uc004dzc.2_Intron|NLGN3_uc011mps.1_5'UTR|NLGN3_uc011mpr.1_5'UTR	NM_018977	NP_061850			neuroligin 3						neuron cell-cell adhesion|positive regulation of synaptogenesis|receptor-mediated endocytosis|social behavior|synapse assembly	cell surface|endocytic vesicle|integral to plasma membrane|synapse	neurexin binding|receptor activity			ovary(1)	1	Renal(35;0.156)																	---	---	---	---
XIST	7503	broad.mit.edu	37	X	73066772	73066772	+	RNA	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:73066772A>G	uc004ebm.1	-	1		c.5817T>C				NR_001564				Homo sapiens cDNA: FLJ21545 fis, clone COL06195.												0																		---	---	---	---
SRPX2	27286	broad.mit.edu	37	X	99925828	99925828	+	Silent	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:99925828C>A	uc004egb.2	+	11	1722	c.1242C>A	c.(1240-1242)TCC>TCA	p.S414S		NM_014467	NP_055282	O60687	SRPX2_HUMAN	sushi-repeat-containing protein, X-linked 2	414					angiogenesis|cell motility|cell-cell adhesion|positive regulation of cell migration involved in sprouting angiogenesis|regulation of phosphorylation	cytoplasm|extracellular region	receptor binding			ovary(2)	2																OREG0019890	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
GLA	2717	broad.mit.edu	37	X	100653412	100653412	+	Silent	SNP	G	A	A	rs151208856	byFrequency	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:100653412G>A	uc004ehl.1	-	6	1055	c.945C>T	c.(943-945)GAC>GAT	p.D315D		NM_000169	NP_000160	P06280	AGAL_HUMAN	alpha-galactosidase A precursor	315					glycoside catabolic process|glycosphingolipid catabolic process|glycosylceramide catabolic process|negative regulation of nitric oxide biosynthetic process|negative regulation of nitric-oxide synthase activity|oligosaccharide metabolic process	extracellular region|Golgi apparatus|lysosome	cation binding|protein homodimerization activity|raffinose alpha-galactosidase activity|receptor binding				0					Agalsidase beta(DB00103)													---	---	---	---
TMSB15B	286527	broad.mit.edu	37	X	103220136	103220136	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:103220136T>C	uc010noz.2	+	3	239	c.125T>C	c.(124-126)GTT>GCT	p.V42A	TMSB15B_uc004elo.3_RNA|TMSB15B_uc004elq.3_RNA	NM_194324	NP_919305	P0CG34	TB15A_HUMAN	thymosin beta15b	42					actin cytoskeleton organization|sequestering of actin monomers	cytoplasm|cytoskeleton	actin binding			skin(1)	1																		---	---	---	---
ESX1	80712	broad.mit.edu	37	X	103495292	103495292	+	Missense_Mutation	SNP	A	G	G	rs144173947	byFrequency	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:103495292A>G	uc004ely.2	-	4	896	c.838T>C	c.(838-840)TCA>CCA	p.S280P		NM_153448	NP_703149	Q8N693	ESX1_HUMAN	extraembryonic, spermatogenesis, homeobox	280	5.|15 X 9 AA tandem repeats of P-P-x-x-P-x- P-P-x.				negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1																		---	---	---	---
ESX1	80712	broad.mit.edu	37	X	103495293	103495293	+	Silent	SNP	G	C	C	rs147779192	byFrequency	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:103495293G>C	uc004ely.2	-	4	895	c.837C>G	c.(835-837)GGC>GGG	p.G279G		NM_153448	NP_703149	Q8N693	ESX1_HUMAN	extraembryonic, spermatogenesis, homeobox	279	4.|15 X 9 AA tandem repeats of P-P-x-x-P-x- P-P-x.				negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1																		---	---	---	---
IL1RAPL2	26280	broad.mit.edu	37	X	104992947	104992947	+	Intron	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:104992947C>T	uc004elz.1	+							NM_017416	NP_059112			interleukin 1 receptor accessory protein-like 2						central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(2)|ovary(1)	3																		---	---	---	---
IL1RAPL2	26280	broad.mit.edu	37	X	104999178	104999178	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:104999178G>T	uc004elz.1	+	10	1956	c.1200G>T	c.(1198-1200)AAG>AAT	p.K400N		NM_017416	NP_059112	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	400	Cytoplasmic (Potential).|TIR.				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(2)|ovary(1)	3																		---	---	---	---
CXorf57	55086	broad.mit.edu	37	X	105905498	105905498	+	Silent	SNP	C	T	T	rs140805762	byFrequency	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:105905498C>T	uc004emi.3	+	12	2383	c.2232C>T	c.(2230-2232)AGC>AGT	p.S744S	CXorf57_uc004emj.3_Silent_p.S647S	NM_018015	NP_060485	Q6NSI4	CX057_HUMAN	hypothetical protein LOC55086	744										ovary(1)|lung(1)|breast(1)	3																		---	---	---	---
CXorf57	55086	broad.mit.edu	37	X	105912413	105912413	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:105912413A>G	uc004emi.3	+	13	2441	c.2290A>G	c.(2290-2292)ATC>GTC	p.I764V	CXorf57_uc004emj.3_Missense_Mutation_p.I667V	NM_018015	NP_060485	Q6NSI4	CX057_HUMAN	hypothetical protein LOC55086	764										ovary(1)|lung(1)|breast(1)	3																		---	---	---	---
TSC22D3	1831	broad.mit.edu	37	X	106960004	106960004	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:106960004G>A	uc004eng.2	-	1	288	c.38C>T	c.(37-39)GCG>GTG	p.A13V	TSC22D3_uc004enf.2_5'Flank|TSC22D3_uc004enh.2_Intron|TSC22D3_uc004eni.2_Intron|TSC22D3_uc004enj.2_Intron	NM_004089	NP_004080	Q99576	T22D3_HUMAN	TSC22 domain family, member 3 isoform 2	13	AP1-binding (By similarity).						sequence-specific DNA binding transcription factor activity				0																		---	---	---	---
VSIG1	340547	broad.mit.edu	37	X	107319359	107319359	+	Silent	SNP	C	T	T	rs150102865	byFrequency	TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:107319359C>T	uc004eno.2	+	6	902	c.741C>T	c.(739-741)GCC>GCT	p.A247A	VSIG1_uc011msk.1_Silent_p.A283A	NM_182607	NP_872413	Q86XK7	VSIG1_HUMAN	V-set and immunoglobulin domain containing 1	247	Helical; (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2																		---	---	---	---
HTR2C	3358	broad.mit.edu	37	X	114141262	114141262	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:114141262G>A	uc004epu.1	+	6	1389	c.661G>A	c.(661-663)GTA>ATA	p.V221I	HTR2C_uc010nqc.1_Missense_Mutation_p.V221I|HTR2C_uc004epv.1_Missense_Mutation_p.R189H	NM_000868	NP_000859	P28335	5HT2C_HUMAN	5-hydroxytryptamine (serotonin) receptor 2C	221	Helical; Name=5; (By similarity).				cGMP biosynthetic process|ERK1 and ERK2 cascade|feeding behavior|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	cytoplasm|integral to membrane|nucleus|plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|protein binding|serotonin binding|serotonin receptor activity			ovary(3)	3					Chlorprothixene(DB01239)|Clozapine(DB00363)|Dexfenfluramine(DB01191)|Fenfluramine(DB00574)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Olanzapine(DB00334)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Tramadol(DB00193)|Ziprasidone(DB00246)													---	---	---	---
IL13RA2	3598	broad.mit.edu	37	X	114249138	114249138	+	Splice_Site	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:114249138C>T	uc004epx.2	-	4	372	c.247_splice	c.e4-1	p.T83_splice	IL13RA2_uc010nqd.1_Splice_Site_p.T83_splice	NM_000640	NP_000631			interleukin 13 receptor, alpha 2 precursor							extracellular space|integral to membrane|soluble fraction	cytokine receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3																		---	---	---	---
ZNF449	203523	broad.mit.edu	37	X	134494750	134494750	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:134494750A>G	uc004eys.2	+	5	1471	c.1306A>G	c.(1306-1308)AGA>GGA	p.R436G	ZNF449_uc004eyt.2_Missense_Mutation_p.R316G|ZNF449_uc004eyu.2_Missense_Mutation_p.R242G	NM_152695	NP_689908	Q6P9G9	ZN449_HUMAN	zinc finger protein 449	436	C2H2-type 5.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
ZIC3	7547	broad.mit.edu	37	X	136648848	136648848	+	5'UTR	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:136648848C>T	uc004fak.2	+	1						NM_003413	NP_003404			zinc finger protein of the cerebellum 3						cell differentiation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
SPANXC	64663	broad.mit.edu	37	X	140336551	140336551	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:140336551C>T	uc004fbk.2	-	1	96	c.40G>A	c.(40-42)GTC>ATC	p.V14I	SPANXC_uc004fbl.2_Intron	NM_022661	NP_073152	Q9NY87	SPNXC_HUMAN	sperm protein associated with the nucleus, X	14						cytoplasm|nucleus					0	Acute lymphoblastic leukemia(192;7.65e-05)																	---	---	---	---
MAGEA4	4103	broad.mit.edu	37	X	151092878	151092878	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:151092878A>G	uc004fez.2	+	3	898	c.742A>G	c.(742-744)ACC>GCC	p.T248A	MAGEA4_uc004ffa.2_Missense_Mutation_p.T248A|MAGEA4_uc004ffb.2_Missense_Mutation_p.T248A|MAGEA4_uc004ffc.2_Missense_Mutation_p.T248A|MAGEA4_uc004ffd.2_Missense_Mutation_p.T248A	NM_002362	NP_002353	P43358	MAGA4_HUMAN	melanoma antigen family A, 4	248	MAGE.						protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
MIR105-1	406897	broad.mit.edu	37	X	151560699	151560699	+	RNA	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:151560699G>T	hsa-mir-105-1|MI0000111	-			c.73G>T			GABRA3_uc010ntk.1_Intron|uc004ffo.2_RNA																	0																		---	---	---	---
PNMA3	29944	broad.mit.edu	37	X	152226568	152226568	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:152226568C>T	uc004fhc.2	+	2	1492	c.1156C>T	c.(1156-1158)CGG>TGG	p.R386W	PNMA5_uc004fha.3_5'Flank|PNMA3_uc004fhd.2_5'Flank	NM_013364	NP_037496	Q9UL41	PNMA3_HUMAN	paraneoplastic cancer-testis-brain antigen	386	Arg-rich.				apoptosis	nucleolus	nucleic acid binding|zinc ion binding			skin(2)|large_intestine(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
ARHGAP4	393	broad.mit.edu	37	X	153175819	153175819	+	Silent	SNP	G	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153175819G>A	uc004fjk.1	-	17	2004	c.1962C>T	c.(1960-1962)TAC>TAT	p.Y654Y	ARHGAP4_uc004fjj.1_Silent_p.Y5Y|ARHGAP4_uc011mzf.1_Silent_p.Y631Y|ARHGAP4_uc004fjl.1_Silent_p.Y694Y|ARHGAP4_uc010nup.1_Intron	NM_001666	NP_001657	P98171	RHG04_HUMAN	Rho GTPase activating protein 4 isoform 2	654	Rho-GAP.				apoptosis|cytoskeleton organization|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|Rho protein signal transduction	cytosol|focal adhesion|nucleus	Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			central_nervous_system(1)	1	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
HCFC1	3054	broad.mit.edu	37	X	153224859	153224859	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153224859C>A	uc004fjp.2	-	9	2056	c.1528G>T	c.(1528-1530)GGG>TGG	p.G510W		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	510					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
FLNA	2316	broad.mit.edu	37	X	153583313	153583313	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153583313G>T	uc004fkk.2	-	31	5346	c.5097C>A	c.(5095-5097)GAC>GAA	p.D1699E	FLNA_uc004fki.2_5'Flank|FLNA_uc011mzn.1_5'UTR|FLNA_uc010nuu.1_Missense_Mutation_p.D1691E	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	1699	Filamin 15.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)															OREG0003595	type=REGULATORY REGION|Gene=FLNA|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	---	---	---	---
MPP1	4354	broad.mit.edu	37	X	154020457	154020457	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4442-01A-01D-1158-08	TCGA-CG-4442-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:154020457A>G	uc004fmp.1	-	2	321	c.206T>C	c.(205-207)GTG>GCG	p.V69A	MPP1_uc010nvg.1_Missense_Mutation_p.V69A|MPP1_uc011mzv.1_Missense_Mutation_p.V39A|MPP1_uc004fmq.1_Missense_Mutation_p.V23A|MPP1_uc011mzw.1_Intron|MPP1_uc010nvh.1_Intron	NM_002436	NP_002427	Q00013	EM55_HUMAN	palmitoylated membrane protein 1	69					regulation of neutrophil chemotaxis|signal transduction	integral to plasma membrane|membrane fraction|stereocilium	guanylate kinase activity|protein binding			ovary(2)|central_nervous_system(1)	3	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)																	---	---	---	---
