Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_status	validation_method	validation_tumor_sample	validation_alt_allele
CTPS	1503	broad.mit.edu	37	1	41449292	41449292	+	Intron	DEL	T	-	-	rs67035391		TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:41449292delT	uc001cgk.3	+						CTPS_uc010ojo.1_Intron|CTPS_uc010ojp.1_Intron|CTPS_uc001cgl.3_Intron	NM_001905	NP_001896			CTP synthase						CTP biosynthetic process|glutamine metabolic process|nucleobase, nucleoside and nucleotide interconversion|response to drug	cytosol	ATP binding|CTP synthase activity|protein binding				0	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Breast(333;0.1)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)			L-Glutamine(DB00130)													---	---	---	---
Unknown	0	broad.mit.edu	37	1	48554990	48554990	+	IGR	DEL	T	-	-			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:48554990delT								FOXD2 (648628 upstream) : SKINTL (12397 downstream)																																			---	---	---	---
ANXA9	8416	broad.mit.edu	37	1	150960204	150960204	+	Intron	DEL	A	-	-			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:150960204delA	uc001ewa.2	+							NM_003568	NP_003559			annexin A9						cell-cell adhesion	cell surface|cytosol	acetylcholine receptor activity|calcium ion binding|calcium-dependent phospholipid binding|phosphatidylserine binding|protein homodimerization activity				0	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)															---	---	---	---
TNN	63923	broad.mit.edu	37	1	175049103	175049104	+	Intron	INS	-	GT	GT	rs142891850	by1000genomes	TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:175049103_175049104insGT	uc001gkl.1	+						TNN_uc010pmx.1_Intron	NM_022093	NP_071376			tenascin N precursor						cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)														---	---	---	---
WDR26	80232	broad.mit.edu	37	1	224586837	224586837	+	Intron	DEL	T	-	-			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:224586837delT	uc001hop.3	-						WDR26_uc001hoq.3_Intron|WDR26_uc010pvh.1_Intron	NM_025160	NP_079436			WD repeat domain 26 isoform a							cytoplasm|nucleus					0				GBM - Glioblastoma multiforme(131;0.0104)														---	---	---	---
UGP2	7360	broad.mit.edu	37	2	64082655	64082658	+	Intron	DEL	TTTT	-	-	rs71393335		TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:64082655_64082658delTTTT	uc002scm.2	+						UGP2_uc002scl.2_Intron|UGP2_uc010ypx.1_Intron	NM_006759	NP_006750			UDP-glucose pyrophosphorylase 2 isoform a						glycogen biosynthetic process|phosphorylation|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	metal ion binding|protein binding|UTP:glucose-1-phosphate uridylyltransferase activity				0																		---	---	---	---
UGGT1	56886	broad.mit.edu	37	2	128900552	128900552	+	Intron	DEL	A	-	-			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:128900552delA	uc002tps.2	+						UGGT1_uc010fme.1_Intron|UGGT1_uc002tpr.2_Intron	NM_020120	NP_064505			UDP-glucose ceramide glucosyltransferase-like 1						'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	2	217474994	217474995	+	IGR	DEL	TT	-	-	rs71401155		TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:217474994_217474995delTT								RPL37A (108808 upstream) : IGFBP2 (23132 downstream)																																			---	---	---	---
TTLL4	9654	broad.mit.edu	37	2	219616633	219616634	+	Intron	INS	-	T	T	rs67473408		TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:219616633_219616634insT	uc002viy.2	+						TTLL4_uc010zkl.1_Intron|TTLL4_uc010fvx.2_Intron|TTLL4_uc010zkm.1_Intron	NM_014640	NP_055455			tubulin tyrosine ligase-like family, member 4						protein polyglutamylation	cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			ovary(2)|skin(1)	3		Renal(207;0.0915)		Epithelial(149;5.03e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0101)														---	---	---	---
VPS8	23355	broad.mit.edu	37	3	184766499	184766499	+	Intron	DEL	C	-	-			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:184766499delC	uc003fpb.1	+						VPS8_uc010hyd.1_Intron|VPS8_uc010hye.1_Intron	NM_015303	NP_056118			vacuolar protein sorting 8 homolog isoform b								zinc ion binding			ovary(1)	1	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)															---	---	---	---
PIGX	54965	broad.mit.edu	37	3	196458052	196458052	+	Intron	DEL	A	-	-			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:196458052delA	uc010iaj.2	+						PIGX_uc003fwx.3_Intron|PIGX_uc011btx.1_Intron	NM_017861	NP_060331			phosphatidylinositol glycan anchor biosynthesis,						C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane					0	all_cancers(143;1.41e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.07e-23)|all cancers(36;1.08e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00322)														---	---	---	---
Unknown	0	broad.mit.edu	37	4	10412981	10412982	+	IGR	INS	-	CT	CT	rs143148489		TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:10412981_10412982insCT								WDR1 (294408 upstream) : ZNF518B (28523 downstream)																																			---	---	---	---
MANBA	4126	broad.mit.edu	37	4	103673002	103673002	+	Intron	DEL	A	-	-			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:103673002delA	uc003hwg.2	-						MANBA_uc011ces.1_Intron	NM_005908	NP_005899			mannosidase, beta A, lysosomal precursor						carbohydrate metabolic process|protein modification process	lysosome	beta-mannosidase activity|cation binding			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;4.44e-08)														---	---	---	---
Unknown	0	broad.mit.edu	37	4	117300449	117300450	+	IGR	DEL	TT	-	-	rs34804858		TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:117300449_117300450delTT								MIR1973 (79525 upstream) : TRAM1L1 (704266 downstream)																																			---	---	---	---
NEK1	4750	broad.mit.edu	37	4	170428352	170428352	+	Intron	DEL	G	-	-	rs58355251		TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:170428352delG	uc003isb.1	-						NEK1_uc003isc.1_Intron|NEK1_uc003isd.1_Intron|NEK1_uc003ise.1_Intron|NEK1_uc003isf.1_Intron	NM_012224	NP_036356			NIMA-related kinase 1						cell division|cilium assembly|mitosis	nucleus|pericentriolar material	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(3)|ovary(2)|large_intestine(1)	6		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)|KIRC - Kidney renal clear cell carcinoma(143;0.0325)|Kidney(143;0.0385)|LUSC - Lung squamous cell carcinoma(193;0.14)														---	---	---	---
KIAA1430	57587	broad.mit.edu	37	4	186097263	186097264	+	Intron	INS	-	TTTT	TTTT	rs113459393		TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:186097263_186097264insTTTT	uc003ixf.3	-						KIAA1430_uc003ixg.2_Intron	NM_020827	NP_065878			hypothetical protein LOC57587												0		all_lung(41;1.19e-13)|Lung NSC(41;3.16e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00872)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;9.44e-26)|Epithelial(43;2.64e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.66e-11)|Colorectal(24;6.03e-05)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.000331)|COAD - Colon adenocarcinoma(29;0.000427)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00924)|READ - Rectum adenocarcinoma(43;0.165)														---	---	---	---
CRHBP	1393	broad.mit.edu	37	5	76264841	76264842	+	3'UTR	DEL	CA	-	-			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:76264841_76264842delCA	uc003ker.2	+	7						NM_001882	NP_001873			corticotropin releasing hormone binding protein						female pregnancy|learning or memory|signal transduction	soluble fraction					0		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-51)|Epithelial(54;8.79e-46)|all cancers(79;2.49e-41)														---	---	---	---
AFF4	27125	broad.mit.edu	37	5	132234183	132234183	+	Intron	DEL	T	-	-	rs67779737		TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:132234183delT	uc003kyd.2	-						AFF4_uc011cxk.1_Intron|AFF4_uc003kye.1_Intron	NM_014423	NP_055238			ALL1 fused gene from 5q31						transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|kidney(2)|skin(1)	5		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)															---	---	---	---
Unknown	0	broad.mit.edu	37	6	87821814	87821814	+	IGR	DEL	A	-	-			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:87821814delA								CGA (16990 upstream) : ZNF292 (40737 downstream)																																			---	---	---	---
SLC22A16	85413	broad.mit.edu	37	6	110767862	110767863	+	Intron	DEL	AC	-	-			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:110767862_110767863delAC	uc003puf.2	-						SLC22A16_uc003pue.2_Intron	NM_033125	NP_149116			solute carrier family 22, member 16						acid secretion|cell differentiation|multicellular organismal development|single fertilization|sperm motility|spermatogenesis	integral to membrane	carnitine transporter activity			ovary(1)	1		all_cancers(87;0.00221)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0485)|Colorectal(196;0.101)		OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.0921)|all cancers(137;0.115)														---	---	---	---
UST	10090	broad.mit.edu	37	6	149274908	149274908	+	Intron	DEL	A	-	-	rs147617058		TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:149274908delA	uc003qmg.2	+							NM_005715	NP_005706			uronyl-2-sulfotransferase						protein sulfation	Golgi membrane|integral to membrane	sulfotransferase activity			ovary(2)	2		Ovarian(120;0.0907)		OV - Ovarian serous cystadenocarcinoma(155;1.78e-10)|GBM - Glioblastoma multiforme(68;0.138)														---	---	---	---
MTHFD1L	25902	broad.mit.edu	37	6	151421170	151421170	+	Intron	DEL	C	-	-			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:151421170delC	uc003qob.2	+						MTHFD1L_uc003qoc.2_Intron	NM_015440	NP_056255			methylenetetrahydrofolate dehydrogenase (NADP+						folic acid-containing compound biosynthetic process|formate metabolic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|protein homodimerization activity			ovary(3)|large_intestine(1)	4		Ovarian(120;0.128)		OV - Ovarian serous cystadenocarcinoma(155;8.7e-12)														---	---	---	---
Unknown	0	broad.mit.edu	37	7	65150816	65150816	+	Intron	DEL	A	-	-			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:65150816delA	uc003tud.1	-						INTS4L2_uc003tue.2_Intron					Homo sapiens hypothetical LOC441242, mRNA (cDNA clone MGC:87648 IMAGE:5267764), complete cds.																														---	---	---	---
Unknown	0	broad.mit.edu	37	7	65226569	65226569	+	Intron	DEL	T	-	-			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:65226569delT	uc003tud.1	-						CCT6P1_uc003tug.2_Intron|CCT6P1_uc003tuh.2_Intron|CCT6P1_uc003tui.2_Intron					Homo sapiens hypothetical LOC441242, mRNA (cDNA clone MGC:87648 IMAGE:5267764), complete cds.																														---	---	---	---
UBE3C	9690	broad.mit.edu	37	7	156962829	156962829	+	Intron	DEL	C	-	-	rs66735407		TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:156962829delC	uc010lqs.2	+						UBE3C_uc003wnf.2_Intron|UBE3C_uc003wng.2_Intron	NM_014671	NP_055486			ubiquitin protein ligase E3C						protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(2)|large_intestine(1)	5		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)														---	---	---	---
PKHD1L1	93035	broad.mit.edu	37	8	110454524	110454525	+	Intron	DEL	AT	-	-	rs10586369		TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:110454524_110454525delAT	uc003yne.2	+							NM_177531	NP_803875			fibrocystin L precursor						immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)												HNSCC(38;0.096)			---	---	---	---
C9orf114	51490	broad.mit.edu	37	9	131590774	131590775	+	Intron	INS	-	A	A	rs35247950		TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131590774_131590775insA	uc004bwd.2	-						C9orf114_uc004bwe.2_Intron|C9orf114_uc010mym.2_Intron	NM_016390	NP_057474			hypothetical protein LOC51490												0																		---	---	---	---
ARHGAP12	94134	broad.mit.edu	37	10	32141656	32141657	+	Intron	DEL	TC	-	-			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:32141656_32141657delTC	uc001ivz.1	-						ARHGAP12_uc001ivy.1_Intron|ARHGAP12_uc009xls.2_Intron|ARHGAP12_uc001iwb.1_Intron|ARHGAP12_uc001iwc.1_Intron|ARHGAP12_uc009xlq.1_Intron|ARHGAP12_uc001iwd.1_Intron|ARHGAP12_uc009xlr.1_Intron	NM_018287	NP_060757			Rho GTPase activating protein 12						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0		Prostate(175;0.0199)																---	---	---	---
Unknown	0	broad.mit.edu	37	10	71193238	71193239	+	IGR	INS	-	AC	AC	rs139709581	by1000genomes	TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:71193238_71193239insAC								TACR2 (16564 upstream) : TSPAN15 (17987 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	11	11158570	11158570	+	IGR	DEL	A	-	-	rs10574607		TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:11158570delA								ZBED5 (278950 upstream) : GALNTL4 (133851 downstream)																																			---	---	---	---
KBTBD4	55709	broad.mit.edu	37	11	47597411	47597412	+	Intron	INS	-	T	T	rs35653820		TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:47597411_47597412insT	uc001nfx.2	-						NDUFS3_uc001nft.3_Intron|KBTBD4_uc001nfw.1_Intron|KBTBD4_uc001nfz.2_Intron|KBTBD4_uc001nfy.2_Intron	NM_016506	NP_057590			kelch repeat and BTB (POZ) domain containing 4											ovary(1)|central_nervous_system(1)	2																		---	---	---	---
GRIK4	2900	broad.mit.edu	37	11	120732466	120732466	+	Intron	DEL	T	-	-			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:120732466delT	uc001pxn.2	+						GRIK4_uc009zav.1_Intron|GRIK4_uc009zaw.1_Intron|GRIK4_uc009zax.1_Intron	NM_014619	NP_055434			glutamate receptor KA1 precursor						glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|central_nervous_system(1)	3		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)													---	---	---	---
IFFO1	25900	broad.mit.edu	37	12	6658357	6658357	+	Intron	DEL	A	-	-	rs72489368		TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:6658357delA	uc001qpd.1	-						IFFO1_uc001qoy.2_Intron|IFFO1_uc001qpa.1_5'Flank|IFFO1_uc001qpb.1_Intron|IFFO1_uc001qpe.1_Intron|IFFO1_uc010sfe.1_Intron|IFFO1_uc001qpf.1_Intron|IFFO1_uc001qoz.1_5'Flank|IFFO1_uc001qpc.1_Intron|IFFO1_uc001qpg.2_5'Flank	NM_080730	NP_542768			intermediate filament family orphan isoform 2							intermediate filament					0																		---	---	---	---
Unknown	0	broad.mit.edu	37	12	9391909	9391909	+	5'Flank	DEL	T	-	-			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:9391909delT	uc001qvm.1	+											Homo sapiens cDNA FLJ44260 fis, clone TLIVE2000979.																														---	---	---	---
DPP8	54878	broad.mit.edu	37	15	65746475	65746476	+	Intron	DEL	AA	-	-			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:65746475_65746476delAA	uc002aov.2	-						DPP8_uc002aow.2_Intron|DPP8_uc010uiv.1_Intron|DPP8_uc002aox.2_Intron|DPP8_uc002aoy.2_Intron|DPP8_uc002aoz.2_Intron|DPP8_uc010bhj.2_Intron|DPP8_uc002apa.2_Intron|DPP8_uc010bhi.2_Intron|DPP8_uc010bhk.1_Intron	NM_130434	NP_569118			dipeptidyl peptidase 8 isoform 1						immune response|proteolysis	cytoplasm|membrane|nucleus	aminopeptidase activity|dipeptidyl-peptidase activity|serine-type peptidase activity			ovary(1)	1																		---	---	---	---
MEGF11	84465	broad.mit.edu	37	15	66257236	66257237	+	Intron	INS	-	A	A	rs138144863	by1000genomes	TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:66257236_66257237insA	uc002apm.2	-						MEGF11_uc002apl.2_Intron|MEGF11_uc002apn.1_Intron	NM_032445	NP_115821			multiple EGF-like-domains 11 precursor							basolateral plasma membrane|integral to membrane				pancreas(1)	1																		---	---	---	---
RNF112	7732	broad.mit.edu	37	17	19314936	19314936	+	Intron	DEL	C	-	-			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:19314936delC	uc010vyw.1	+						RNF112_uc010vyu.1_Intron|RNF112_uc010vyv.1_Intron|RNF112_uc010vyx.1_5'Flank	NM_007148	NP_009079			ring finger protein 112								GTP binding|GTPase activity|zinc ion binding			ovary(2)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	17	21228979	21228981	+	IGR	DEL	TCC	-	-	rs36117559		TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:21228979_21228981delTCC								MAP2K3 (10430 upstream) : KCNJ12 (50718 downstream)																																			---	---	---	---
SAMD14	201191	broad.mit.edu	37	17	48202122	48202123	+	Intron	INS	-	GCACGC	GCACGC	rs149885965	by1000genomes	TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:48202122_48202123insGCACGC	uc002iqg.2	-						SAMD14_uc002iqe.2_5'Flank|SAMD14_uc002iqf.2_Intron	NM_174920	NP_777580			sterile alpha motif domain containing 14												0																		---	---	---	---
MOCOS	55034	broad.mit.edu	37	18	33784959	33784960	+	Intron	INS	-	AAAAA	AAAAA			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:33784959_33784960insAAAAA	uc002kzq.3	+							NM_017947	NP_060417			molybdenum cofactor sulfurase						Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	lyase activity|Mo-molybdopterin cofactor sulfurase activity|molybdenum ion binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)													---	---	---	---
HM13	81502	broad.mit.edu	37	20	30156903	30156904	+	Intron	INS	-	T	T	rs11376444		TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:30156903_30156904insT	uc002wwe.2	+						HM13_uc002wwc.2_Intron|HM13_uc002wwd.2_Intron|HM13_uc002wwf.2_Intron|HM13_uc010gdu.2_Intron	NM_030789	NP_110416			minor histocompatibility antigen 13 isoform 1						membrane protein proteolysis	cell surface|endoplasmic reticulum membrane|integral to membrane|plasma membrane	aspartic-type endopeptidase activity|protein binding			breast(1)	1	all_cancers(5;3.44e-05)|Lung NSC(7;4.38e-06)|all_lung(7;7.65e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		all cancers(5;0.000479)|Colorectal(19;0.00202)|COAD - Colon adenocarcinoma(19;0.0264)													OREG0025852	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
NKAIN4	128414	broad.mit.edu	37	20	61874138	61874139	+	Intron	INS	-	G	G	rs147746767	by1000genomes	TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:61874138_61874139insG	uc002yek.2	-							NM_152864	NP_690603			Na+/K+ transporting ATPase interacting 4							integral to membrane|plasma membrane					0	all_cancers(38;2.72e-09)																	---	---	---	---
Unknown	0	broad.mit.edu	37	22	16419352	16419352	+	IGR	DEL	T	-	-			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:16419352delT								POTEH (131415 upstream) : OR11H1 (29474 downstream)																																			---	---	---	---
SPEN	23013	broad.mit.edu	37	1	16242779	16242779	+	Intron	SNP	G	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:16242779G>T	uc001axk.1	+						SPEN_uc010obp.1_Intron	NM_015001	NP_055816			spen homolog, transcriptional regulator						interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)														---	---	---	---
CLCNKB	1188	broad.mit.edu	37	1	16377482	16377482	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:16377482G>A	uc001axw.3	+	12	1246	c.1166G>A	c.(1165-1167)TGG>TAG	p.W389*	FAM131C_uc010obz.1_Intron|CLCNKB_uc001axx.3_Nonsense_Mutation_p.W389*|CLCNKB_uc001axy.3_Nonsense_Mutation_p.W220*	NM_000085	NP_000076	P51801	CLCKB_HUMAN	chloride channel Kb isoform 1	389					excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			skin(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
EPHA2	1969	broad.mit.edu	37	1	16464906	16464906	+	Missense_Mutation	SNP	A	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:16464906A>T	uc001aya.1	-	4	980	c.843T>A	c.(841-843)TTT>TTA	p.F281L	EPHA2_uc010oca.1_Missense_Mutation_p.F281L	NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	281	Extracellular (Potential).|Cys-rich.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)													---	---	---	---
CLIC4	25932	broad.mit.edu	37	1	25124240	25124240	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:25124240G>A	uc001bjo.2	+	2	365	c.80G>A	c.(79-81)AGT>AAT	p.S27N	CLIC4_uc001bjn.2_RNA|CLIC4_uc001bjp.1_Intron	NM_013943	NP_039234	Q9Y696	CLIC4_HUMAN	chloride intracellular channel 4	27	Required for insertion into the membrane (Probable).				cellular response to calcium ion|establishment or maintenance of apical/basal cell polarity|keratinocyte differentiation|negative regulation of cell migration|regulation of cytoskeleton organization	actin cytoskeleton|apical part of cell|cell surface|cell-cell junction|centrosome|chloride channel complex|cytoplasmic vesicle membrane|cytosol|microvillus|midbody|mitochondrion|nuclear matrix|perinuclear region of cytoplasm|soluble fraction	voltage-gated chloride channel activity				0		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000778)|all_lung(284;0.00106)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0479)|OV - Ovarian serous cystadenocarcinoma(117;1.06e-24)|Colorectal(126;1.03e-07)|COAD - Colon adenocarcinoma(152;4.93e-06)|STAD - Stomach adenocarcinoma(196;0.000418)|GBM - Glioblastoma multiforme(114;0.000451)|BRCA - Breast invasive adenocarcinoma(304;0.00215)|KIRC - Kidney renal clear cell carcinoma(1967;0.00216)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.18)														---	---	---	---
SPOCD1	90853	broad.mit.edu	37	1	32265646	32265646	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:32265646C>T	uc001bts.1	-	5	1757	c.1699G>A	c.(1699-1701)GAC>AAC	p.D567N	SPOCD1_uc001btt.2_5'Flank|SPOCD1_uc001btu.2_Missense_Mutation_p.D567N|SPOCD1_uc001btv.2_Missense_Mutation_p.D60N|SPOCD1_uc001btw.1_5'Flank	NM_144569	NP_653170	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	567					transcription, DNA-dependent					ovary(5)|breast(1)	6		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)														---	---	---	---
TRIT1	54802	broad.mit.edu	37	1	40307584	40307584	+	Silent	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:40307584C>T	uc010oiz.1	-	11	1250	c.1236G>A	c.(1234-1236)GCG>GCA	p.A412A	TRIT1_uc001cec.3_RNA|TRIT1_uc001ced.3_Silent_p.A108A|TRIT1_uc001cee.3_RNA|TRIT1_uc001cef.3_RNA|TRIT1_uc001ceg.3_Silent_p.A166A|TRIT1_uc001ceh.3_Silent_p.A166A|TRIT1_uc009vvv.2_Silent_p.A245A|TRIT1_uc001cei.3_Silent_p.A166A|TRIT1_uc001ceq.2_Silent_p.A108A|TRIT1_uc001cek.2_Silent_p.A108A|TRIT1_uc009vvx.2_RNA|TRIT1_uc001cel.2_RNA|TRIT1_uc001cem.2_Silent_p.A330A|TRIT1_uc001cen.2_Silent_p.A166A|TRIT1_uc001ceo.2_Silent_p.A166A|TRIT1_uc001cep.2_Silent_p.A166A	NM_017646	NP_060116	Q9H3H1	MOD5_HUMAN	tRNA isopentenyltransferase 1 precursor	412	Matrin-type.				tRNA processing	mitochondrion	ATP binding|metal ion binding|tRNA dimethylallyltransferase activity			ovary(1)	1	all_cancers(7;4.55e-14)|all_lung(5;1.23e-16)|all_epithelial(6;2.17e-16)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;3.29e-18)|Epithelial(16;3.07e-17)|all cancers(16;6.21e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)															---	---	---	---
CYP4A22	284541	broad.mit.edu	37	1	47609043	47609043	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:47609043C>T	uc001cqv.1	+	5	664	c.613C>T	c.(613-615)CAG>TAG	p.Q205*	CYP4A22_uc009vyo.2_Nonsense_Mutation_p.Q205*|CYP4A22_uc009vyp.2_Nonsense_Mutation_p.Q205*	NM_001010969	NP_001010969	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A,	205						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			skin(2)|ovary(1)|breast(1)	4																		---	---	---	---
FAM159A	348378	broad.mit.edu	37	1	53099190	53099190	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:53099190G>A	uc001cuf.2	+	1	125	c.25G>A	c.(25-27)GTG>ATG	p.V9M	FAM159A_uc001cug.1_RNA|FAM159A_uc001cuh.2_RNA	NM_001042693	NP_001036158	Q6UWV7	F159A_HUMAN	hypothetical protein LOC348378	9						integral to membrane					0																		---	---	---	---
C8A	731	broad.mit.edu	37	1	57341886	57341886	+	Intron	SNP	A	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:57341886A>C	uc001cyo.2	+							NM_000562	NP_000553			complement component 8, alpha polypeptide						complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3																		---	---	---	---
LRRIQ3	127255	broad.mit.edu	37	1	74507160	74507160	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:74507160T>G	uc001dfy.3	-	7	1647	c.1455A>C	c.(1453-1455)CAA>CAC	p.Q485H	LRRIQ3_uc001dfz.3_Intron	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	485										ovary(2)	2																		---	---	---	---
LRRIQ3	127255	broad.mit.edu	37	1	74621559	74621559	+	Intron	SNP	A	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:74621559A>T	uc001dfy.3	-						LRRIQ3_uc001dfz.3_Intron	NM_001105659	NP_001099129			leucine-rich repeats and IQ motif containing 3											ovary(2)	2																		---	---	---	---
ELTD1	64123	broad.mit.edu	37	1	79392711	79392711	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:79392711A>C	uc001diq.3	-	8	1099	c.943T>G	c.(943-945)TTC>GTC	p.F315V		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	315	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)														---	---	---	---
ELTD1	64123	broad.mit.edu	37	1	79403793	79403793	+	Missense_Mutation	SNP	T	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:79403793T>A	uc001diq.3	-	5	724	c.568A>T	c.(568-570)ACT>TCT	p.T190S		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	190	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)														---	---	---	---
LPHN2	23266	broad.mit.edu	37	1	82416057	82416057	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:82416057T>G	uc001dit.3	+	7	1564	c.1383T>G	c.(1381-1383)ATT>ATG	p.I461M	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Missense_Mutation_p.I461M|LPHN2_uc001div.2_Missense_Mutation_p.I461M|LPHN2_uc009wcd.2_Missense_Mutation_p.I461M|LPHN2_uc001diw.2_Missense_Mutation_p.I32M	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	461	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)														---	---	---	---
LPHN2	23266	broad.mit.edu	37	1	82436222	82436222	+	Intron	SNP	A	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:82436222A>G	uc001dit.3	+						LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Intron|LPHN2_uc001div.2_Intron|LPHN2_uc009wcd.2_Intron|LPHN2_uc001diw.2_Intron|LPHN2_uc009wce.1_Intron	NM_012302	NP_036434			latrophilin 2 precursor						neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)														---	---	---	---
CLCA3P	9629	broad.mit.edu	37	1	87108241	87108241	+	RNA	SNP	T	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:87108241T>C	uc010osh.1	+	6		c.768T>C				NR_024604				Synthetic construct DNA, clone: pF1KB7225, Homo sapiens CLCA3 gene for chloride channel, calcium activated, family member 3, without stop codon, in Flexi system.												0																		---	---	---	---
HFM1	164045	broad.mit.edu	37	1	91851178	91851178	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:91851178G>T	uc001doa.3	-	5	808	c.708C>A	c.(706-708)TTC>TTA	p.F236L	HFM1_uc010osu.1_Intron|HFM1_uc010osv.1_Intron|HFM1_uc001doc.1_Missense_Mutation_p.F236L	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	236							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)														---	---	---	---
COL11A1	1301	broad.mit.edu	37	1	103345385	103345385	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:103345385A>C	uc001dul.2	-	66	5446	c.5128T>G	c.(5128-5130)TTC>GTC	p.F1710V	COL11A1_uc001duk.2_Missense_Mutation_p.F906V|COL11A1_uc001dum.2_Missense_Mutation_p.F1722V|COL11A1_uc001dun.2_Missense_Mutation_p.F1671V|COL11A1_uc009weh.2_Missense_Mutation_p.F1594V	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1710	Fibrillar collagen NC1.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)														---	---	---	---
CELSR2	1952	broad.mit.edu	37	1	109794410	109794410	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:109794410G>A	uc001dxa.3	+	1	1770	c.1709G>A	c.(1708-1710)CGG>CAG	p.R570Q		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	570	Cadherin 4.|Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)														---	---	---	---
SMG5	23381	broad.mit.edu	37	1	156246933	156246933	+	Missense_Mutation	SNP	A	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156246933A>T	uc001foc.3	-	4	546	c.397T>A	c.(397-399)TAC>AAC	p.Y133N		NM_015327	NP_056142	Q9UPR3	SMG5_HUMAN	SMG5 homolog nonsense mediated mRNA decay	133					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			ovary(2)|skin(2)|pancreas(1)	5	Hepatocellular(266;0.158)																	---	---	---	---
CD1E	913	broad.mit.edu	37	1	158324361	158324361	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:158324361T>G	uc001fse.2	+	2	492	c.253T>G	c.(253-255)TTC>GTC	p.F85V	CD1E_uc010pid.1_Missense_Mutation_p.F83V|CD1E_uc010pie.1_Intron|CD1E_uc010pif.1_Intron|CD1E_uc001fsd.2_Missense_Mutation_p.F85V|CD1E_uc001fsk.2_Missense_Mutation_p.F85V|CD1E_uc001fsj.2_Missense_Mutation_p.F85V|CD1E_uc001fsc.2_Intron|CD1E_uc010pig.1_Intron|CD1E_uc001fsa.2_Intron|CD1E_uc001fsf.2_Missense_Mutation_p.F85V|CD1E_uc001fry.2_Missense_Mutation_p.F85V|CD1E_uc001fsg.2_Intron|CD1E_uc001fsh.2_Intron|CD1E_uc001fsi.2_Missense_Mutation_p.F85V|CD1E_uc009wsv.2_Intron|CD1E_uc001frz.2_Missense_Mutation_p.F85V|CD1E_uc009wsw.2_5'Flank	NM_030893	NP_112155	P15812	CD1E_HUMAN	CD1E antigen isoform a precursor	85					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				skin(3)	3	all_hematologic(112;0.0378)																	---	---	---	---
OR10Z1	128368	broad.mit.edu	37	1	158576489	158576489	+	Silent	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:158576489G>A	uc010pio.1	+	1	261	c.261G>A	c.(259-261)GGG>GGA	p.G87G		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	87	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)																	---	---	---	---
PTPRC	5788	broad.mit.edu	37	1	198711490	198711490	+	Missense_Mutation	SNP	A	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:198711490A>T	uc001gur.1	+	25	2865	c.2685A>T	c.(2683-2685)CAA>CAT	p.Q895H	PTPRC_uc001gus.1_Missense_Mutation_p.Q847H|PTPRC_uc001gut.1_Missense_Mutation_p.Q734H	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	895	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 1.	Substrate (By similarity).			axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12																		---	---	---	---
FMOD	2331	broad.mit.edu	37	1	203311556	203311556	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:203311556C>T	uc001gzr.2	-	3	1182	c.1046G>A	c.(1045-1047)CGC>CAC	p.R349H	FMOD_uc010pqi.1_RNA	NM_002023	NP_002014	Q06828	FMOD_HUMAN	fibromodulin precursor	349	LRR 11.				transforming growth factor beta receptor complex assembly	extracellular space|proteinaceous extracellular matrix				ovary(2)|breast(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.171)													OREG0014119	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
RAB3GAP2	25782	broad.mit.edu	37	1	220345380	220345380	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:220345380C>T	uc010puk.1	-	23	2592	c.2428G>A	c.(2428-2430)GAG>AAG	p.E810K	RAB3GAP2_uc001hmf.2_RNA|RAB3GAP2_uc001hmg.2_Missense_Mutation_p.E390K	NM_012414	NP_036546	Q9H2M9	RBGPR_HUMAN	rab3 GTPase-activating protein, non-catalytic	810					intracellular protein transport	cytoplasm|soluble fraction	GTPase activator activity|protein heterodimerization activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(131;0.0443)														---	---	---	---
ERO1LB	56605	broad.mit.edu	37	1	236399099	236399099	+	Silent	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:236399099C>T	uc001hxt.2	-	8	919	c.663G>A	c.(661-663)GCG>GCA	p.A221A		NM_019891	NP_063944	Q86YB8	ERO1B_HUMAN	endoplasmic reticulum oxidoreductin 1-Lbeta	221					electron transport chain|protein thiol-disulfide exchange|transport	endoplasmic reticulum membrane	flavin adenine dinucleotide binding|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor|unfolded protein binding				0	Ovarian(103;0.0634)|Breast(184;0.247)	all_cancers(173;0.123)|Acute lymphoblastic leukemia(190;0.205)|Prostate(94;0.219)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)															---	---	---	---
FMN2	56776	broad.mit.edu	37	1	240256759	240256759	+	Silent	SNP	C	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:240256759C>A	uc010pyd.1	+	1	1575	c.1350C>A	c.(1348-1350)TCC>TCA	p.S450S	FMN2_uc010pye.1_Silent_p.S450S	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	450					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)															---	---	---	---
FMN2	56776	broad.mit.edu	37	1	240555824	240555824	+	Silent	SNP	A	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:240555824A>G	uc010pyd.1	+	15	5097	c.4872A>G	c.(4870-4872)CAA>CAG	p.Q1624Q	FMN2_uc010pye.1_Silent_p.Q1628Q|FMN2_uc010pyf.1_Silent_p.Q239Q|FMN2_uc010pyg.1_Silent_p.Q220Q	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1624	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)															---	---	---	---
SNTG2	54221	broad.mit.edu	37	2	1263223	1263223	+	Intron	SNP	T	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:1263223T>C	uc002qwq.2	+						SNTG2_uc010ewi.2_Intron	NM_018968	NP_061841			syntrophin, gamma 2						central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)														---	---	---	---
MYT1L	23040	broad.mit.edu	37	2	1893207	1893207	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:1893207T>C	uc002qxe.2	-	16	3153	c.2326A>G	c.(2326-2328)AGC>GGC	p.S776G	MYT1L_uc002qxd.2_Missense_Mutation_p.S774G|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	776					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)														---	---	---	---
ATP6V1C2	245973	broad.mit.edu	37	2	10912687	10912687	+	Missense_Mutation	SNP	C	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:10912687C>G	uc002ras.2	+	8	698	c.589C>G	c.(589-591)CAA>GAA	p.Q197E	ATP6V1C2_uc002rat.2_Missense_Mutation_p.Q197E	NM_001039362	NP_001034451	Q8NEY4	VATC2_HUMAN	vacuolar H+ ATPase C2 isoform a	197					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|proton-transporting V-type ATPase, V1 domain				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.15)|OV - Ovarian serous cystadenocarcinoma(76;0.152)														---	---	---	---
CENPO	79172	broad.mit.edu	37	2	25040575	25040575	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:25040575G>A	uc002rfo.1	+	7	992	c.803G>A	c.(802-804)CGA>CAA	p.R268Q	CENPO_uc002rfp.1_Missense_Mutation_p.R262Q|CENPO_uc002rfq.1_Missense_Mutation_p.R268Q	NM_024322	NP_077298	Q9BU64	CENPO_HUMAN	centromere protein O	268					cell division|CenH3-containing nucleosome assembly at centromere|chromosome segregation|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)																	---	---	---	---
OTX1	5013	broad.mit.edu	37	2	63283145	63283145	+	Silent	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:63283145G>A	uc002scd.2	+	5	1007	c.759G>A	c.(757-759)GCG>GCA	p.A253A	OTX1_uc010ypt.1_Silent_p.A187A	NM_014562	NP_055377	P32242	OTX1_HUMAN	orthodenticle homeobox 1	253						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(2)	2	Lung NSC(7;0.121)|all_lung(7;0.211)																	---	---	---	---
Unknown	0	broad.mit.edu	37	2	90229525	90229525	+	Intron	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:90229525T>G	uc010fhm.2	+											Parts of antibodies, mostly variable regions.																														---	---	---	---
PCDP1	200373	broad.mit.edu	37	2	120385314	120385314	+	Silent	SNP	G	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:120385314G>T	uc002tmb.2	+	17	1836	c.744G>T	c.(742-744)CTG>CTT	p.L248L	PCDP1_uc010yyq.1_Silent_p.L378L	NM_001029996	NP_001025167	Q4G0U5	PCDP1_HUMAN	primary ciliary dyskinesia protein 1	534						cilium	calmodulin binding				0	Colorectal(110;0.196)																	---	---	---	---
LRP1B	53353	broad.mit.edu	37	2	141201953	141201953	+	Silent	SNP	A	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:141201953A>G	uc002tvj.1	-	65	11212	c.10240T>C	c.(10240-10242)TTA>CTA	p.L3414L		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3414	Extracellular (Potential).|LDL-receptor class A 23.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)											TSP Lung(27;0.18)			---	---	---	---
LRP1B	53353	broad.mit.edu	37	2	141250226	141250226	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:141250226T>C	uc002tvj.1	-	57	10043	c.9071A>G	c.(9070-9072)GAG>GGG	p.E3024G		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3024	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)											TSP Lung(27;0.18)			---	---	---	---
ACVR2A	92	broad.mit.edu	37	2	148653912	148653912	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:148653912T>G	uc002twg.2	+	3	367	c.98T>G	c.(97-99)TTT>TGT	p.F33C	ACVR2A_uc010zbn.1_Intron|ACVR2A_uc002twh.2_Missense_Mutation_p.F33C	NM_001616	NP_001607	P27037	AVR2A_HUMAN	activin A receptor, type IIA precursor	33	Extracellular (Potential).				activin receptor signaling pathway|BMP signaling pathway|positive regulation of activin receptor signaling pathway|positive regulation of bone mineralization|positive regulation of erythrocyte differentiation|positive regulation of osteoblast differentiation|positive regulation of protein phosphorylation	cytoplasm|inhibin-betaglycan-ActRII complex|integral to plasma membrane	ATP binding|coreceptor activity|inhibin beta-A binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|transforming growth factor beta receptor activity			stomach(8)|large_intestine(2)|lung(1)|breast(1)|kidney(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.0969)														---	---	---	---
SCN1A	6323	broad.mit.edu	37	2	166893015	166893015	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:166893015A>C	uc010zcz.1	-	16	2957	c.2939T>G	c.(2938-2940)CTT>CGT	p.L980R	SCN1A_uc002udo.3_Missense_Mutation_p.L860R|SCN1A_uc010fpk.2_Missense_Mutation_p.L832R	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	991	Helical; Name=S6 of repeat II; (By similarity).|II.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)													---	---	---	---
TTN	7273	broad.mit.edu	37	2	179437107	179437107	+	Silent	SNP	T	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179437107T>C	uc010zfg.1	-	275	66272	c.66048A>G	c.(66046-66048)CAA>CAG	p.Q22016Q	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.Q15711Q|TTN_uc010zfi.1_Silent_p.Q15644Q|TTN_uc010zfj.1_Silent_p.Q15519Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22943							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179472135	179472135	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179472135T>G	uc010zfg.1	-	226	45800	c.45576A>C	c.(45574-45576)GAA>GAC	p.E15192D	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E8887D|TTN_uc010zfi.1_Missense_Mutation_p.E8820D|TTN_uc010zfj.1_Missense_Mutation_p.E8695D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16119							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
ZNF804A	91752	broad.mit.edu	37	2	185802505	185802505	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:185802505A>C	uc002uph.2	+	4	2976	c.2382A>C	c.(2380-2382)GAA>GAC	p.E794D		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	794						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11																		---	---	---	---
NAB1	4664	broad.mit.edu	37	2	191524263	191524263	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:191524263C>T	uc002usb.2	+	4	933	c.361C>T	c.(361-363)CGG>TGG	p.R121W	NAB1_uc010fsc.2_Missense_Mutation_p.R121W|NAB1_uc010fsd.2_Missense_Mutation_p.R121W|NAB1_uc002usc.2_Missense_Mutation_p.R121W|NAB1_uc010zgh.1_Missense_Mutation_p.R121W	NM_005966	NP_005957	Q13506	NAB1_HUMAN	NGFI-A binding protein 1	121					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0			OV - Ovarian serous cystadenocarcinoma(117;0.00318)|Epithelial(96;0.0405)|all cancers(119;0.109)															---	---	---	---
MAP2	4133	broad.mit.edu	37	2	210569185	210569185	+	Intron	SNP	G	T	T	rs79214059		TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:210569185G>T	uc002vde.1	+						MAP2_uc002vdd.1_Missense_Mutation_p.L176F|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Missense_Mutation_p.L176F|MAP2_uc002vdi.1_Intron	NM_002374	NP_002365			microtubule-associated protein 2 isoform 1						central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)													---	---	---	---
FEV	54738	broad.mit.edu	37	2	219846688	219846688	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:219846688C>T	uc002vji.1	-	3	1000	c.418G>A	c.(418-420)GCG>ACG	p.A140T		NM_017521	NP_059991	Q99581	FEV_HUMAN	FEV (ETS oncogene family)	140	May mediate active transcriptional repression.|Ala-rich.				cell differentiation|nervous system development|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity		EWSR1/FEV(10)|FUS/FEV(2)	bone(10)|soft_tissue(2)	12		Renal(207;0.0474)		Epithelial(149;9.77e-07)|all cancers(144;0.000167)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)				T	EWSR1| FUS	Ewing sarcoma								---	---	---	---
IHH	3549	broad.mit.edu	37	2	219920533	219920533	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:219920533C>T	uc002vjo.1	-	3	632	c.632G>A	c.(631-633)CGC>CAC	p.R211H		NM_002181	NP_002172	Q14623	IHH_HUMAN	Indian hedgehog homolog precursor	211					cell-cell signaling|intein-mediated protein splicing|proteolysis	extracellular space|plasma membrane	cholesterol binding|patched binding|peptidase activity			breast(1)	1		Renal(207;0.0915)		Epithelial(149;1.13e-06)|all cancers(144;0.000188)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)														---	---	---	---
PAX3	5077	broad.mit.edu	37	2	223085988	223085988	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:223085988G>A	uc010fwo.2	-	6	1277	c.911C>T	c.(910-912)ACG>ATG	p.T304M	PAX3_uc002vmt.1_Missense_Mutation_p.T304M|PAX3_uc002vmy.1_Missense_Mutation_p.T303M|PAX3_uc002vmv.1_Missense_Mutation_p.T304M|PAX3_uc002vmw.1_Missense_Mutation_p.T304M|PAX3_uc002vmx.1_Missense_Mutation_p.T304M	NM_181457	NP_852122	P23760	PAX3_HUMAN	paired box 3 isoform PAX3	304					apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX3/FOXO1(749)|PAX3/NCOA1(8)|PAX3/NCOA2(4)	soft_tissue(761)|ovary(4)|skin(1)	766		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)				T	FOXO1A|NCOA1	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome						---	---	---	---
PER2	8864	broad.mit.edu	37	2	239176768	239176768	+	Missense_Mutation	SNP	C	T	T	rs150684914	byFrequency	TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:239176768C>T	uc002vyc.2	-	8	1133	c.896G>A	c.(895-897)CGG>CAG	p.R299Q	PER2_uc010znv.1_Missense_Mutation_p.R299Q|PER2_uc010znw.1_Missense_Mutation_p.R299Q|PER2_uc010fyx.1_Missense_Mutation_p.R299Q	NM_022817	NP_073728	O15055	PER2_HUMAN	period 2	299					circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			upper_aerodigestive_tract(1)|breast(1)	2		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)														---	---	---	---
KCNH8	131096	broad.mit.edu	37	3	19575469	19575469	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:19575469T>G	uc003cbk.1	+	16	3397	c.3202T>G	c.(3202-3204)TTA>GTA	p.L1068V	KCNH8_uc010hex.1_Missense_Mutation_p.L529V	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	1068	Cytoplasmic (Potential).					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5																		---	---	---	---
MYRIP	25924	broad.mit.edu	37	3	40275351	40275351	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:40275351A>C	uc003cka.2	+	12	2042	c.1907A>C	c.(1906-1908)AAG>ACG	p.K636T	MYRIP_uc010hhu.2_Intron|MYRIP_uc010hhv.2_Intron|MYRIP_uc010hhw.2_Missense_Mutation_p.K547T|MYRIP_uc011ayz.1_Missense_Mutation_p.K449T|uc003ckb.2_Intron	NM_015460	NP_056275	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	636	Actin-binding.				intracellular protein transport		actin binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)														---	---	---	---
NBEAL2	23218	broad.mit.edu	37	3	47049917	47049917	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:47049917C>T	uc003cqp.2	+	51	8043	c.7864C>T	c.(7864-7866)CGT>TGT	p.R2622C	NBEAL2_uc010hjm.1_Missense_Mutation_p.R1999C|NBEAL2_uc010hjn.1_Missense_Mutation_p.R988C|NBEAL2_uc010hjo.1_Missense_Mutation_p.R182C	NM_015175	NP_055990	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	2622							binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)														---	---	---	---
GRM2	2912	broad.mit.edu	37	3	51746766	51746766	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:51746766G>A	uc010hlv.2	+	3	967	c.728G>A	c.(727-729)CGT>CAT	p.R243H	GRM2_uc003dbo.3_Intron|GRM2_uc010hlu.2_RNA	NM_000839	NP_000830	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2 isoform a	243	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)													---	---	---	---
PRICKLE2	166336	broad.mit.edu	37	3	64085187	64085187	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:64085187C>T	uc003dmf.2	-	8	2661	c.2075G>A	c.(2074-2076)CGC>CAC	p.R692H		NM_198859	NP_942559	Q7Z3G6	PRIC2_HUMAN	prickle-like 2	692	Arg-rich.					cytoplasm|nuclear membrane	zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)														---	---	---	---
ADAMTS9	56999	broad.mit.edu	37	3	64619467	64619467	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:64619467A>C	uc003dmg.2	-	13	1977	c.1945T>G	c.(1945-1947)TTC>GTC	p.F649V	ADAMTS9_uc011bfo.1_Missense_Mutation_p.F621V|ADAMTS9_uc003dmh.1_Missense_Mutation_p.F478V|ADAMTS9_uc003dmk.1_Missense_Mutation_p.F649V	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	649	Cys-rich.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)														---	---	---	---
CNTN3	5067	broad.mit.edu	37	3	74418456	74418456	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:74418456T>G	uc003dpm.1	-	7	910	c.830A>C	c.(829-831)AAG>ACG	p.K277T		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	277	Ig-like C2-type 3.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)														---	---	---	---
EPHA3	2042	broad.mit.edu	37	3	89176408	89176408	+	Silent	SNP	T	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:89176408T>C	uc003dqy.2	+	2	363	c.138T>C	c.(136-138)TCT>TCC	p.S46S	EPHA3_uc003dqx.1_Silent_p.S46S|EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	46	Extracellular (Potential).					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)											TSP Lung(6;0.00050)			---	---	---	---
STXBP5L	9515	broad.mit.edu	37	3	120764302	120764302	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:120764302T>G	uc003eec.3	+	5	530	c.390T>G	c.(388-390)AGT>AGG	p.S130R	STXBP5L_uc011bji.1_Missense_Mutation_p.S130R	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	130	WD 2.				exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)														---	---	---	---
STXBP5L	9515	broad.mit.edu	37	3	120977937	120977937	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:120977937T>G	uc003eec.3	+	18	2020	c.1880T>G	c.(1879-1881)CTT>CGT	p.L627R	STXBP5L_uc011bji.1_Missense_Mutation_p.L627R	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	627	WD 9.				exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)														---	---	---	---
RASA2	5922	broad.mit.edu	37	3	141305575	141305575	+	Silent	SNP	C	T	T	rs138963413		TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:141305575C>T	uc003etz.1	+	19	1914	c.1914C>T	c.(1912-1914)CTC>CTT	p.L638L	RASA2_uc010huq.1_Silent_p.L638L|RASA2_uc003eua.1_Silent_p.L638L|RASA2_uc011bnc.1_Silent_p.L230L	NM_006506	NP_006497	Q15283	RASA2_HUMAN	RAS p21 protein activator 2	638	PH.				intracellular signal transduction|negative regulation of Ras protein signal transduction	intracellular membrane-bounded organelle|intrinsic to internal side of plasma membrane|perinuclear region of cytoplasm	metal ion binding|Ras GTPase activator activity			ovary(2)|lung(2)|breast(1)|skin(1)	6																		---	---	---	---
DHX36	170506	broad.mit.edu	37	3	153995437	153995437	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:153995437C>T	uc003ezy.3	-	23	2719	c.2638G>A	c.(2638-2640)GAC>AAC	p.D880N	DHX36_uc010hvq.2_Missense_Mutation_p.D866N|DHX36_uc003ezz.3_Missense_Mutation_p.D851N	NM_020865	NP_065916	Q9H2U1	DHX36_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 36	880						cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)															---	---	---	---
PPP2R2C	5522	broad.mit.edu	37	4	6335368	6335368	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:6335368C>T	uc003gjc.2	-	7	1251	c.881G>A	c.(880-882)CGC>CAC	p.R294H	PPP2R2C_uc003gjb.2_Missense_Mutation_p.R277H|PPP2R2C_uc011bwd.1_Missense_Mutation_p.R287H|PPP2R2C_uc011bwe.1_Missense_Mutation_p.R287H|PPP2R2C_uc003gja.2_Missense_Mutation_p.R294H|PPP2R2C_uc003gjd.1_Missense_Mutation_p.R382H	NM_020416	NP_065149	Q9Y2T4	2ABG_HUMAN	gamma isoform of regulatory subunit B55, protein	294	WD 5.				signal transduction	protein phosphatase type 2A complex	protein phosphatase type 2A regulator activity			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4																OREG0016071	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
SLC34A2	10568	broad.mit.edu	37	4	25677985	25677985	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:25677985G>A	uc003grr.2	+	13	1768	c.1687G>A	c.(1687-1689)GTC>ATC	p.V563I	SLC34A2_uc003grs.2_Missense_Mutation_p.V562I|SLC34A2_uc010iev.2_Missense_Mutation_p.V562I	NM_006424	NP_006415	O95436	NPT2B_HUMAN	solute carrier family 34 (sodium phosphate),	563	Helical; Name=M8; (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			skin(3)|ovary(1)|kidney(1)	5		Breast(46;0.0503)																---	---	---	---
EPHA5	2044	broad.mit.edu	37	4	66356149	66356149	+	Silent	SNP	A	G	G	rs142589245		TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:66356149A>G	uc003hcy.2	-	5	1541	c.1348T>C	c.(1348-1350)TTG>CTG	p.L450L	EPHA5_uc003hcx.2_Silent_p.L381L|EPHA5_uc003hcz.2_Silent_p.L450L|EPHA5_uc011cah.1_Silent_p.L450L|EPHA5_uc011cai.1_Silent_p.L450L|EPHA5_uc003hda.2_Silent_p.L450L	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	450	Fibronectin type-III 1.|Extracellular (Potential).				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24															TSP Lung(17;0.13)			---	---	---	---
UNC5C	8633	broad.mit.edu	37	4	96140209	96140209	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:96140209T>G	uc003htp.1	-	9	1710	c.1556A>C	c.(1555-1557)AAC>ACC	p.N519T	UNC5C_uc010ilc.1_Missense_Mutation_p.N538T|UNC5C_uc003htq.2_Missense_Mutation_p.N538T	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	519	Cytoplasmic (Potential).				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)														---	---	---	---
DDIT4L	115265	broad.mit.edu	37	4	101108874	101108874	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:101108874A>G	uc003hvq.2	-	3	745	c.542T>C	c.(541-543)CTT>CCT	p.L181P		NM_145244	NP_660287	Q96D03	DDT4L_HUMAN	DNA-damage-inducible transcript 4-like	181					negative regulation of signal transduction	cytoplasm				ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;5.75e-09)														---	---	---	---
SEC24B	10427	broad.mit.edu	37	4	110447513	110447513	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:110447513T>G	uc003hzk.2	+	17	2978	c.2923T>G	c.(2923-2925)TTA>GTA	p.L975V	SEC24B_uc003hzl.2_Missense_Mutation_p.L940V|SEC24B_uc011cfp.1_Missense_Mutation_p.L1005V|SEC24B_uc011cfq.1_Missense_Mutation_p.L974V|SEC24B_uc011cfr.1_Missense_Mutation_p.L939V	NM_006323	NP_006314	O95487	SC24B_HUMAN	SEC24 (S. cerevisiae) homolog B isoform a	975					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)														---	---	---	---
NDST4	64579	broad.mit.edu	37	4	115898357	115898357	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:115898357T>G	uc003ibu.2	-	3	1731	c.1052A>C	c.(1051-1053)AAG>ACG	p.K351T	NDST4_uc010imw.2_Intron	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	351	Lumenal (Potential).|Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)														---	---	---	---
FAT4	79633	broad.mit.edu	37	4	126237573	126237573	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:126237573T>G	uc003ifj.3	+	1	7	c.7T>G	c.(7-9)TTA>GTA	p.L3V		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18																OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
FAT4	79633	broad.mit.edu	37	4	126370493	126370493	+	Silent	SNP	T	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:126370493T>C	uc003ifj.3	+	9	8322	c.8322T>C	c.(8320-8322)TCT>TCC	p.S2774S	FAT4_uc011cgp.1_Silent_p.S1072S|FAT4_uc003ifi.1_Silent_p.S252S	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	2774	Cadherin 27.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18																		---	---	---	---
TDO2	6999	broad.mit.edu	37	4	156838589	156838589	+	Silent	SNP	T	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:156838589T>C	uc003ipf.1	+	10	1003	c.939T>C	c.(937-939)TCT>TCC	p.S313S		NM_005651	NP_005642	P48775	T23O_HUMAN	tryptophan 2,3-dioxygenase	313					tryptophan catabolic process to kynurenine	cytosol	tryptophan 2,3-dioxygenase activity				0	all_hematologic(180;0.24)	Renal(120;0.0854)		KIRC - Kidney renal clear cell carcinoma(143;0.0455)|Kidney(143;0.0568)|COAD - Colon adenocarcinoma(41;0.141)	L-Tryptophan(DB00150)													---	---	---	---
FSTL5	56884	broad.mit.edu	37	4	162508614	162508614	+	Silent	SNP	T	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:162508614T>C	uc003iqh.2	-	8	1444	c.1008A>G	c.(1006-1008)CAA>CAG	p.Q336Q	FSTL5_uc003iqi.2_Silent_p.Q335Q|FSTL5_uc010iqv.2_Silent_p.Q335Q	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	336	Ig-like 1.					extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)														---	---	---	---
MARCH1	55016	broad.mit.edu	37	4	165118867	165118867	+	Intron	SNP	T	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:165118867T>C	uc003iqs.1	-						ANP32C_uc011cjk.1_5'Flank	NM_017923	NP_060393			membrane-associated RING-CH protein I						antigen processing and presentation of peptide antigen via MHC class II|immune response	cytoplasmic vesicle membrane|early endosome membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|plasma membrane	MHC protein binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)	2	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)																---	---	---	---
SPOCK3	50859	broad.mit.edu	37	4	167833778	167833778	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:167833778G>A	uc003iri.1	-	6	617	c.476C>T	c.(475-477)TCT>TTT	p.S159F	SPOCK3_uc011cjp.1_Missense_Mutation_p.S156F|SPOCK3_uc011cjq.1_Missense_Mutation_p.S168F|SPOCK3_uc011cjr.1_Missense_Mutation_p.S39F|SPOCK3_uc003irj.1_Missense_Mutation_p.S156F|SPOCK3_uc011cjs.1_Missense_Mutation_p.S108F|SPOCK3_uc011cjt.1_Missense_Mutation_p.S67F|SPOCK3_uc011cju.1_Missense_Mutation_p.S52F|SPOCK3_uc011cjv.1_Intron|SPOCK3_uc003irk.3_Missense_Mutation_p.S156F|SPOCK3_uc011cjw.1_Intron	NM_016950	NP_058646	Q9BQ16	TICN3_HUMAN	testican 3 isoform 2	159	Kazal-like.				signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)														---	---	---	---
CDH18	1016	broad.mit.edu	37	5	19473497	19473497	+	Silent	SNP	A	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:19473497A>G	uc003jgc.2	-	12	2588	c.2211T>C	c.(2209-2211)ACT>ACC	p.T737T	CDH18_uc003jgd.2_Silent_p.T737T|CDH18_uc011cnm.1_3'UTR	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	737	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)																	---	---	---	---
CDH12	1010	broad.mit.edu	37	5	21755750	21755750	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:21755750A>G	uc010iuc.2	-	11	2293	c.1835T>C	c.(1834-1836)CTT>CCT	p.L612P	CDH12_uc011cno.1_Missense_Mutation_p.L572P|CDH12_uc003jgk.2_Missense_Mutation_p.L612P|uc003jgj.2_Intron	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	612	Helical; (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2															HNSCC(59;0.17)			---	---	---	---
ADAMTS12	81792	broad.mit.edu	37	5	33648923	33648923	+	Intron	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:33648923T>G	uc003jia.1	-						ADAMTS12_uc010iuq.1_Intron	NM_030955	NP_112217			ADAM metallopeptidase with thrombospondin type 1						proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9															HNSCC(64;0.19)			---	---	---	---
SPEF2	79925	broad.mit.edu	37	5	35763665	35763665	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:35763665T>G	uc003jjo.2	+	26	3773	c.3662T>G	c.(3661-3663)GTT>GGT	p.V1221G	SPEF2_uc003jjp.1_Missense_Mutation_p.V707G	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	1221					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)															---	---	---	---
EGFLAM	133584	broad.mit.edu	37	5	38425137	38425137	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:38425137G>T	uc003jlc.1	+	13	2077	c.1753G>T	c.(1753-1755)GCC>TCC	p.A585S	EGFLAM_uc003jlb.1_Missense_Mutation_p.A585S|EGFLAM_uc003jle.1_Missense_Mutation_p.A351S|EGFLAM_uc003jlf.1_5'UTR	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	585	EGF-like 2.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)																	---	---	---	---
GHR	2690	broad.mit.edu	37	5	42689103	42689103	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:42689103A>G	uc003jmt.2	+	4	291	c.248A>G	c.(247-249)CAG>CGG	p.Q83R	GHR_uc011cpq.1_Intron	NM_000163	NP_000154	P10912	GHR_HUMAN	growth hormone receptor precursor	83	Extracellular (Potential).				2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			lung(4)|kidney(1)|skin(1)	6		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)													---	---	---	---
CENPK	64105	broad.mit.edu	37	5	64814467	64814467	+	Intron	SNP	G	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:64814467G>T	uc003jts.2	-						CENPK_uc003jtt.2_Intron|CENPK_uc003jtu.2_Intron	NM_022145	NP_071428			SoxLZ/Sox6 leucine zipper binding protein						CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm					0		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		Lung(70;0.00466)														---	---	---	---
MARVELD2	153562	broad.mit.edu	37	5	68715518	68715518	+	Silent	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:68715518G>A	uc003jwq.2	+	2	365	c.306G>A	c.(304-306)CCG>CCA	p.P102P	MARVELD2_uc010ixf.2_Silent_p.P102P|MARVELD2_uc003jwr.1_Silent_p.P102P|MARVELD2_uc003jws.1_RNA	NM_001038603	NP_001033692	Q8N4S9	MALD2_HUMAN	MARVEL domain containing 2 isoform 1	102	Cytoplasmic (Potential).				sensory perception of sound	integral to membrane|tight junction					0		Lung NSC(167;0.000937)|Prostate(74;0.0187)|Ovarian(174;0.16)		OV - Ovarian serous cystadenocarcinoma(47;7.31e-57)|Epithelial(20;1.05e-52)|all cancers(19;2.63e-48)|Lung(70;0.0183)														---	---	---	---
KCNN2	3781	broad.mit.edu	37	5	113740388	113740388	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:113740388T>G	uc003kqo.2	+	3	1293	c.836T>G	c.(835-837)CTT>CGT	p.L279R		NM_021614	NP_067627	Q9H2S1	KCNN2_HUMAN	small conductance calcium-activated potassium	279						integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			ovary(2)	2		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)														---	---	---	---
PRR16	51334	broad.mit.edu	37	5	120022263	120022263	+	Silent	SNP	T	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:120022263T>A	uc003ksq.2	+	2	937	c.774T>A	c.(772-774)CCT>CCA	p.P258P	PRR16_uc003ksp.2_Silent_p.P235P|PRR16_uc003ksr.2_Silent_p.P188P	NM_016644	NP_057728	Q569H4	PRR16_HUMAN	proline rich 16	258	Pro-rich.									pancreas(2)|ovary(1)	3		all_cancers(142;0.0464)|Prostate(80;0.00446)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.000126)|Epithelial(69;0.000331)|all cancers(49;0.00169)														---	---	---	---
PDLIM4	8572	broad.mit.edu	37	5	131606705	131606705	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:131606705G>A	uc003kwn.2	+	4	502	c.425G>A	c.(424-426)CGC>CAC	p.R142H	uc003kwm.3_Intron|PDLIM4_uc003kwp.2_Missense_Mutation_p.R142H|PDLIM4_uc003kwo.2_Missense_Mutation_p.R142H	NM_003687	NP_003678	P50479	PDLI4_HUMAN	PDZ and LIM domain 4 isoform 1	142							protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)															---	---	---	---
KDM3B	51780	broad.mit.edu	37	5	137717277	137717277	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:137717277G>A	uc003lcy.1	+	6	978	c.778G>A	c.(778-780)GAG>AAG	p.E260K	KDM3B_uc010jew.1_5'UTR	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	260					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11																		---	---	---	---
PCDHB6	56130	broad.mit.edu	37	5	140532003	140532003	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140532003G>A	uc003lir.2	+	1	2165	c.2165G>A	c.(2164-2166)CGC>CAC	p.R722H	PCDHB6_uc011dah.1_Missense_Mutation_p.R586H	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	722	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)															---	---	---	---
PCDHGA8	9708	broad.mit.edu	37	5	140772818	140772818	+	Silent	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140772818G>A	uc003lkd.1	+	1	1336	c.438G>A	c.(436-438)GCG>GCA	p.A146A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkb.3_Silent_p.A146A	NM_032088	NP_114477	Q9Y5G5	PCDG8_HUMAN	protocadherin gamma subfamily A, 8 isoform 1	146	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PPP2R2B	5521	broad.mit.edu	37	5	145972530	145972530	+	Intron	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:145972530T>G	uc003loe.2	-						PPP2R2B_uc010jgm.2_Intron|PPP2R2B_uc003log.3_Intron|PPP2R2B_uc003lof.3_Intron|PPP2R2B_uc003loi.3_Intron|PPP2R2B_uc003loh.3_Intron|PPP2R2B_uc003loj.3_Intron|PPP2R2B_uc003lok.3_Intron|PPP2R2B_uc011dbu.1_Intron|PPP2R2B_uc011dbv.1_Intron	NM_004576	NP_004567			beta isoform of regulatory subunit B55, protein						apoptosis|signal transduction	cytoskeleton|mitochondrial outer membrane|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(1)|prostate(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)															---	---	---	---
GABRA6	2559	broad.mit.edu	37	5	161113274	161113274	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:161113274A>C	uc003lyu.2	+	2	415	c.77A>C	c.(76-78)AAC>ACC	p.N26T		NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	26	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)										TCGA Ovarian(5;0.080)			---	---	---	---
FAM153B	202134	broad.mit.edu	37	5	175526047	175526047	+	Silent	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:175526047C>T	uc003mdk.2	+	10	618	c.561C>T	c.(559-561)AAC>AAT	p.N187N		NM_001079529	NP_001072997	P0C7A2	F153B_HUMAN	hypothetical protein LOC202134	187										ovary(1)	1	all_cancers(89;0.00406)|Renal(175;0.000269)|Lung NSC(126;0.0103)|all_lung(126;0.0164)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)	Kidney(146;0.0965)														---	---	---	---
GRM6	2916	broad.mit.edu	37	5	178416042	178416042	+	Silent	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:178416042G>A	uc003mjr.2	-	6	1427	c.1248C>T	c.(1246-1248)CAC>CAT	p.H416H	GRM6_uc010jla.1_Intron|GRM6_uc003mjs.1_Silent_p.H36H	NM_000843	NP_000834	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6 precursor	416	Extracellular (Potential).				detection of visible light|visual perception	integral to plasma membrane				lung(4)|ovary(2)|breast(1)|pancreas(1)	8	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)														---	---	---	---
HIST1H2BK	85236	broad.mit.edu	37	6	27114186	27114186	+	Intron	SNP	A	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:27114186A>C	uc003nix.1	-						HIST1H2AH_uc003niz.2_5'Flank|hsa-mir-3143|MI0014167_5'Flank	NM_080593	NP_542160			histone cluster 1, H2bk						defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding				0																		---	---	---	---
ZNF311	282890	broad.mit.edu	37	6	28963238	28963238	+	Missense_Mutation	SNP	A	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:28963238A>T	uc003nlu.2	-	7	2054	c.1541T>A	c.(1540-1542)CTT>CAT	p.L514H	ZNF311_uc011dlk.1_Missense_Mutation_p.L422H|ZNF311_uc003nlv.2_Missense_Mutation_p.L422H	NM_001010877	NP_001010877	Q5JNZ3	ZN311_HUMAN	zinc finger protein 311	514	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding				0																		---	---	---	---
OR12D2	26529	broad.mit.edu	37	6	29364723	29364723	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:29364723T>G	uc003nmf.3	+	1	308	c.247T>G	c.(247-249)TTT>GTT	p.F83V		NM_013936	NP_039224	P58182	O12D2_HUMAN	olfactory receptor, family 12, subfamily D,	83	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1																		---	---	---	---
C6orf134	79969	broad.mit.edu	37	6	30596123	30596123	+	Silent	SNP	G	A	A	rs139657037		TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:30596123G>A	uc003nqu.2	+	6	503	c.453G>A	c.(451-453)CCG>CCA	p.P151P	C6orf134_uc003nqr.3_Silent_p.P151P|C6orf134_uc003rdc.2_Silent_p.P151P|C6orf134_uc003nqs.3_Silent_p.P151P|C6orf134_uc003rdd.2_Silent_p.P151P|C6orf134_uc003nqt.2_RNA|C6orf134_uc011dmm.1_Silent_p.P139P|C6orf134_uc003nqv.2_Silent_p.P139P	NM_024909	NP_079185	Q5SQI0	ATAT_HUMAN	hypothetical protein LOC79969 isoform 2	151							tubulin N-acetyltransferase activity				0																		---	---	---	---
HLA-DOA	3111	broad.mit.edu	37	6	32975992	32975992	+	Silent	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:32975992G>A	uc003ocr.2	-	2	205	c.129C>T	c.(127-129)GGC>GGT	p.G43G	HLA-DOA_uc010juj.2_Silent_p.G13G|HLA-DOA_uc010jui.2_Silent_p.G43G	NM_002119	NP_002110	P06340	DOA_HUMAN	major histocompatibility complex, class II, DO	43	Extracellular (Potential).|Alpha-1.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endosome membrane|integral to membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0																		---	---	---	---
MEP1A	4224	broad.mit.edu	37	6	46777187	46777187	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:46777187C>T	uc010jzh.1	+	6	335	c.293C>T	c.(292-294)GCC>GTC	p.A98V	MEP1A_uc011dwg.1_5'UTR|MEP1A_uc011dwh.1_Missense_Mutation_p.A126V|MEP1A_uc011dwi.1_5'UTR	NM_005588	NP_005579	Q16819	MEP1A_HUMAN	meprin A alpha precursor	98	Extracellular (Potential).|Metalloprotease.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			pancreas(2)|ovary(1)	3			Lung(136;0.192)															---	---	---	---
KHDRBS2	202559	broad.mit.edu	37	6	62757869	62757869	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:62757869T>C	uc003peg.2	-	3	497	c.250A>G	c.(250-252)AGA>GGA	p.R84G		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	84	KH.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)														---	---	---	---
COL12A1	1303	broad.mit.edu	37	6	75838046	75838046	+	Silent	SNP	T	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:75838046T>C	uc003phs.2	-	38	6472	c.6306A>G	c.(6304-6306)GGA>GGG	p.G2102G	COL12A1_uc003pht.2_Silent_p.G938G	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	2102	Fibronectin type-III 16.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9																		---	---	---	---
GRIK2	2898	broad.mit.edu	37	6	102069857	102069857	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:102069857T>G	uc003pqp.3	+	2	398	c.149T>G	c.(148-150)ATG>AGG	p.M50R	GRIK2_uc003pqn.2_Missense_Mutation_p.M50R|GRIK2_uc003pqo.3_Missense_Mutation_p.M50R|GRIK2_uc010kcw.2_Missense_Mutation_p.M50R	NM_021956	NP_068775	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	50	Extracellular (Potential).				glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|pancreas(1)|breast(1)|skin(1)	5		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)													---	---	---	---
DNAH11	8701	broad.mit.edu	37	7	21826307	21826307	+	Silent	SNP	C	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:21826307C>A	uc003svc.2	+	60	9715	c.9684C>A	c.(9682-9684)GCC>GCA	p.A3228A		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3228	Stalk (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15														Kartagener_syndrome				---	---	---	---
ANLN	54443	broad.mit.edu	37	7	36492149	36492149	+	Silent	SNP	T	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:36492149T>C	uc003tff.2	+	24	3519	c.3315T>C	c.(3313-3315)GTT>GTC	p.V1105V	ANLN_uc011kaz.1_Silent_p.V1017V|ANLN_uc003tfg.2_Silent_p.V1068V|ANLN_uc010kxe.2_Silent_p.V1067V	NM_018685	NP_061155	Q9NQW6	ANLN_HUMAN	anillin, actin binding protein	1105	PH.|Localization to the cleavage furrow.				cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			ovary(2)|skin(1)	3																		---	---	---	---
ELMO1	9844	broad.mit.edu	37	7	37354471	37354471	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:37354471A>C	uc003tfk.1	-	4	482	c.175T>G	c.(175-177)TTC>GTC	p.F59V	ELMO1_uc010kxg.1_Missense_Mutation_p.F59V	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	59					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6																		---	---	---	---
TXNDC3	51314	broad.mit.edu	37	7	37924817	37924817	+	Silent	SNP	A	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:37924817A>C	uc003tfn.2	+	14	1582	c.1210A>C	c.(1210-1212)AGA>CGA	p.R404R		NM_016616	NP_057700	Q8N427	TXND3_HUMAN	thioredoxin domain containing 3	404	NDK 2.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3														Kartagener_syndrome				---	---	---	---
WBSCR17	64409	broad.mit.edu	37	7	70885974	70885974	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:70885974A>C	uc003tvy.2	+	5	845	c.845A>C	c.(844-846)AAC>ACC	p.N282T	WBSCR17_uc003tvz.2_5'UTR	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	282	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)																---	---	---	---
CHRM2	1129	broad.mit.edu	37	7	136700432	136700432	+	Missense_Mutation	SNP	T	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:136700432T>A	uc003vtf.1	+	4	1443	c.820T>A	c.(820-822)TGT>AGT	p.C274S	CHRM2_uc003vtg.1_Missense_Mutation_p.C274S|CHRM2_uc003vtj.1_Missense_Mutation_p.C274S|CHRM2_uc003vtk.1_Missense_Mutation_p.C274S|CHRM2_uc003vtl.1_Missense_Mutation_p.C274S|CHRM2_uc003vtm.1_Missense_Mutation_p.C274S|CHRM2_uc003vti.1_Missense_Mutation_p.C274S|CHRM2_uc003vto.1_Missense_Mutation_p.C274S|CHRM2_uc003vtn.1_Missense_Mutation_p.C274S|uc003vtp.1_Intron	NM_001006630	NP_001006631	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	274	Cytoplasmic (By similarity).				activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			ovary(4)|central_nervous_system(1)	5					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)													---	---	---	---
TMEM176B	28959	broad.mit.edu	37	7	150493578	150493578	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:150493578A>G	uc003wht.3	-	2	246	c.80T>C	c.(79-81)ATC>ACC	p.I27T	TMEM176B_uc003whu.3_Missense_Mutation_p.I27T|TMEM176B_uc003whv.3_Missense_Mutation_p.I27T|TMEM176B_uc003whw.3_Missense_Mutation_p.I27T	NM_001101313	NP_001094783	Q3YBM2	T176B_HUMAN	transmembrane protein 176B isoform a	27					cell differentiation|organ morphogenesis	integral to membrane|nuclear membrane				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)														---	---	---	---
DLGAP2	9228	broad.mit.edu	37	8	1626407	1626407	+	Silent	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:1626407C>T	uc003wpl.2	+	9	2173	c.2076C>T	c.(2074-2076)AGC>AGT	p.S692S	DLGAP2_uc003wpm.2_Silent_p.S678S	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	771					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)														---	---	---	---
CSMD1	64478	broad.mit.edu	37	8	2949052	2949052	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:2949052T>G	uc011kwk.1	-	48	7664	c.7274A>C	c.(7273-7275)AAG>ACG	p.K2425T	CSMD1_uc011kwj.1_Missense_Mutation_p.K1754T|CSMD1_uc010lrg.2_Missense_Mutation_p.K493T	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2425	CUB 14.|Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)														---	---	---	---
SOX7	83595	broad.mit.edu	37	8	10583717	10583717	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:10583717C>T	uc003wtf.2	-	2	777	c.698G>A	c.(697-699)CGC>CAC	p.R233H	SOX7_uc011kwz.1_Missense_Mutation_p.R285H	NM_031439	NP_113627	Q9BT81	SOX7_HUMAN	SRY-box 7	233					endoderm formation|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of caspase activity|regulation of canonical Wnt receptor signaling pathway	cytoplasm|nucleus	transcription regulatory region DNA binding			breast(1)	1				COAD - Colon adenocarcinoma(149;0.0732)														---	---	---	---
MSR1	4481	broad.mit.edu	37	8	16026107	16026107	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:16026107A>G	uc003wwz.2	-	4	688	c.490T>C	c.(490-492)TCC>CCC	p.S164P	MSR1_uc010lsu.2_Missense_Mutation_p.S182P|MSR1_uc003wxa.2_Missense_Mutation_p.S164P|MSR1_uc003wxb.2_Missense_Mutation_p.S164P|MSR1_uc011kxz.1_Intron	NM_138715	NP_619729	P21757	MSRE_HUMAN	macrophage scavenger receptor 1 isoform type 1	164	Extracellular (Potential).				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			ovary(1)	1				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)														---	---	---	---
FGFR1	2260	broad.mit.edu	37	8	38279423	38279423	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:38279423C>T	uc003xlp.2	-	8	1915	c.973G>A	c.(973-975)GTG>ATG	p.V325M	FGFR1_uc011lbo.1_Missense_Mutation_p.V323M|FGFR1_uc011lbp.1_Missense_Mutation_p.V236M|FGFR1_uc011lbq.1_Missense_Mutation_p.V234M|FGFR1_uc010lwk.2_Missense_Mutation_p.V317M|FGFR1_uc011lbr.1_RNA|FGFR1_uc011lbs.1_Missense_Mutation_p.V165M|FGFR1_uc011lbt.1_Intron|FGFR1_uc011lbu.1_Missense_Mutation_p.V356M|FGFR1_uc011lbv.1_Missense_Mutation_p.V323M|FGFR1_uc011lbw.1_Missense_Mutation_p.V236M|FGFR1_uc011lbx.1_Missense_Mutation_p.V236M	NM_023110	NP_075598	P11362	FGFR1_HUMAN	fibroblast growth factor receptor 1 isoform 1	325	Ig-like C2-type 3.|Extracellular (Potential).				axon guidance|cell growth|insulin receptor signaling pathway|MAPKKK cascade|positive regulation of cell proliferation|skeletal system development	extracellular region|integral to plasma membrane|membrane fraction	ATP binding|fibroblast growth factor receptor activity|heparin binding|protein homodimerization activity			lung(5)|central_nervous_system(5)|stomach(2)|breast(2)|ovary(1)	15	all_cancers(2;9.05e-47)|all_epithelial(2;2.64e-50)|all_lung(3;1.71e-23)|Lung NSC(2;3.61e-23)|Colorectal(12;0.000442)	Breast(189;1.48e-05)|all_lung(54;0.00354)|Lung NSC(58;0.0138)|Hepatocellular(245;0.065)	Epithelial(3;3.96e-34)|all cancers(3;3.06e-30)|BRCA - Breast invasive adenocarcinoma(5;2.28e-21)|COAD - Colon adenocarcinoma(9;0.24)		Palifermin(DB00039)		1	T	BCR|FOP|ZNF198|CEP1	MPD|NHL		Pfeiffer syndrome|Kallman syndrome						---	---	---	---
SGK196	84197	broad.mit.edu	37	8	42958728	42958728	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:42958728G>A	uc003xpw.2	+	4	296	c.37G>A	c.(37-39)GCC>ACC	p.A13T		NM_032237	NP_115613	Q9H5K3	SG196_HUMAN	protein kinase-like protein SgK196	13						integral to membrane	ATP binding|protein kinase activity				0																		---	---	---	---
OPRK1	4986	broad.mit.edu	37	8	54142200	54142200	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:54142200C>T	uc003xrh.1	-	3	1175	c.800G>A	c.(799-801)CGC>CAC	p.R267H	OPRK1_uc003xri.1_Missense_Mutation_p.R267H|OPRK1_uc010lyc.1_Missense_Mutation_p.R178H	NM_000912	NP_000903	P41145	OPRK_HUMAN	opioid receptor, kappa 1	267	Cytoplasmic (Potential).				behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			ovary(1)|skin(1)	2		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)													---	---	---	---
OPRK1	4986	broad.mit.edu	37	8	54147490	54147490	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:54147490A>C	uc003xrh.1	-	2	814	c.439T>G	c.(439-441)TTC>GTC	p.F147V	OPRK1_uc003xri.1_Missense_Mutation_p.F147V|OPRK1_uc010lyc.1_Missense_Mutation_p.F58V	NM_000912	NP_000903	P41145	OPRK_HUMAN	opioid receptor, kappa 1	147	Helical; Name=3; (Potential).				behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			ovary(1)|skin(1)	2		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)													---	---	---	---
PREX2	80243	broad.mit.edu	37	8	69058469	69058469	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:69058469A>C	uc003xxv.1	+	34	4140	c.4113A>C	c.(4111-4113)GAA>GAC	p.E1371D		NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	1371					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17																		---	---	---	---
SULF1	23213	broad.mit.edu	37	8	70536271	70536271	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:70536271A>C	uc010lza.1	+	15	2406	c.1689A>C	c.(1687-1689)GAA>GAC	p.E563D	SULF1_uc003xyd.2_Missense_Mutation_p.E563D|SULF1_uc003xye.2_Missense_Mutation_p.E563D|SULF1_uc003xyf.2_Missense_Mutation_p.E563D|SULF1_uc003xyg.2_Missense_Mutation_p.E563D|SULF1_uc003xyh.1_RNA	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	563					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)															---	---	---	---
NECAB1	64168	broad.mit.edu	37	8	91937774	91937774	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:91937774C>A	uc011lgg.1	+	7	700	c.506C>A	c.(505-507)GCC>GAC	p.A169D		NM_022351	NP_071746	Q8N987	NECA1_HUMAN	N-terminal EF-hand calcium binding protein 1	169					antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity			central_nervous_system(1)	1			BRCA - Breast invasive adenocarcinoma(11;0.0499)															---	---	---	---
RIMS2	9699	broad.mit.edu	37	8	104898091	104898091	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:104898091A>C	uc003yls.2	+	2	839	c.598A>C	c.(598-600)AGT>CGT	p.S200R	RIMS2_uc003ylp.2_Missense_Mutation_p.S422R|RIMS2_uc003ylw.2_Missense_Mutation_p.S230R|RIMS2_uc003ylq.2_Missense_Mutation_p.S230R|RIMS2_uc003ylr.2_Missense_Mutation_p.S230R	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	453					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)												HNSCC(12;0.0054)			---	---	---	---
RIMS2	9699	broad.mit.edu	37	8	104898096	104898096	+	Silent	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:104898096T>G	uc003yls.2	+	2	844	c.603T>G	c.(601-603)TCT>TCG	p.S201S	RIMS2_uc003ylp.2_Silent_p.S423S|RIMS2_uc003ylw.2_Silent_p.S231S|RIMS2_uc003ylq.2_Silent_p.S231S|RIMS2_uc003ylr.2_Silent_p.S231S	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	454					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding	p.S231S(1)		ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)												HNSCC(12;0.0054)			---	---	---	---
RIMS2	9699	broad.mit.edu	37	8	105260951	105260951	+	Silent	SNP	T	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:105260951T>C	uc003yls.2	+	25	3794	c.3553T>C	c.(3553-3555)TTG>CTG	p.L1185L	RIMS2_uc003ylp.2_Silent_p.L1167L|RIMS2_uc003ylw.2_Silent_p.L1174L|RIMS2_uc003ylq.2_Silent_p.L981L|RIMS2_uc003ylr.2_Silent_p.L1006L	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1229					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)												HNSCC(12;0.0054)			---	---	---	---
LRP12	29967	broad.mit.edu	37	8	105503202	105503202	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:105503202A>G	uc003yma.2	-	7	2374	c.2279T>C	c.(2278-2280)CTT>CCT	p.L760P	LRP12_uc003ymb.2_Missense_Mutation_p.L741P|LRP12_uc003ylz.2_Missense_Mutation_p.L166P	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	760	Cytoplasmic (Potential).				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)															---	---	---	---
TRHR	7201	broad.mit.edu	37	8	110131681	110131681	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:110131681T>G	uc003ymz.3	+	2	1210	c.1194T>G	c.(1192-1194)AGT>AGG	p.S398R		NM_003301	NP_003292	P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	398	Cytoplasmic (Potential).					integral to plasma membrane	thyrotropin-releasing hormone receptor activity			skin(2)|lung(1)	3			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)															---	---	---	---
FAM135B	51059	broad.mit.edu	37	8	139158197	139158197	+	Intron	SNP	C	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:139158197C>A	uc003yuy.2	-						FAM135B_uc003yux.2_Intron|FAM135B_uc003yuz.2_Intron|FAM135B_uc003yva.2_Intron|FAM135B_uc003yvb.2_Intron	NM_015912	NP_056996			hypothetical protein LOC51059											ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)												HNSCC(54;0.14)			---	---	---	---
FLJ43860	389690	broad.mit.edu	37	8	142487565	142487565	+	Silent	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:142487565C>T	uc003ywi.2	-	12	1464	c.1383G>A	c.(1381-1383)GAG>GAA	p.E461E	FLJ43860_uc011ljs.1_RNA|FLJ43860_uc010meu.1_RNA	NM_207414	NP_997297	Q6ZUA9	Q6ZUA9_HUMAN	hypothetical protein LOC389690	461							binding				0	all_cancers(97;7.79e-15)|all_epithelial(106;4.52e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)															---	---	---	---
KIAA2026	158358	broad.mit.edu	37	9	5924714	5924714	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:5924714T>G	uc003zjq.3	-	7	2846	c.2630A>C	c.(2629-2631)AAG>ACG	p.K877T	KIAA2026_uc010mht.2_Missense_Mutation_p.K52T	NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	877										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)														---	---	---	---
BNC2	54796	broad.mit.edu	37	9	16436121	16436121	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:16436121A>G	uc003zml.2	-	6	2211	c.2071T>C	c.(2071-2073)TTT>CTT	p.F691L	BNC2_uc011lmw.1_Missense_Mutation_p.F596L|BNC2_uc003zmm.2_Missense_Mutation_p.F649L|BNC2_uc003zmq.1_Missense_Mutation_p.F705L|BNC2_uc003zmr.1_Missense_Mutation_p.F728L|BNC2_uc003zmp.1_Missense_Mutation_p.F719L|BNC2_uc010mij.1_Missense_Mutation_p.F613L|BNC2_uc011lmv.1_Missense_Mutation_p.F517L|BNC2_uc003zmo.1_Missense_Mutation_p.F613L|BNC2_uc003zmj.2_Missense_Mutation_p.F456L|BNC2_uc003zmk.2_RNA|BNC2_uc003zmi.2_Missense_Mutation_p.F456L|BNC2_uc003zmn.1_Missense_Mutation_p.F456L	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	basonuclin 2	691					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(50;9.01e-08)														---	---	---	---
CNTLN	54875	broad.mit.edu	37	9	17415802	17415802	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:17415802A>G	uc003zmz.2	+	17	2836	c.2810A>G	c.(2809-2811)AAG>AGG	p.K937R	CNTLN_uc003zmy.2_Missense_Mutation_p.K938R|CNTLN_uc010mio.2_Missense_Mutation_p.K617R	NM_017738	NP_060208	Q9NXG0	CNTLN_HUMAN	centlein isoform 1	938						centriole|membrane	two-component sensor activity			pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.14e-10)														---	---	---	---
FAM75A5	727905	broad.mit.edu	37	9	65506437	65506437	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:65506437C>T	uc004adx.3	-	4	1152	c.1123G>A	c.(1123-1125)GAC>AAC	p.D375N		NM_015667	NP_056482	Q5VU36	F75A5_HUMAN	hypothetical protein LOC26165	375						integral to membrane					0																		---	---	---	---
ANXA1	301	broad.mit.edu	37	9	75781105	75781105	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:75781105A>G	uc004ajf.1	+	10	873	c.799A>G	c.(799-801)ATC>GTC	p.I267V	ANXA1_uc004aje.1_Missense_Mutation_p.I267V|ANXA1_uc004ajg.1_Missense_Mutation_p.I267V	NM_000700	NP_000691	P04083	ANXA1_HUMAN	annexin I	267	Annexin 3.				alpha-beta T cell differentiation|anti-apoptosis|cell surface receptor linked signaling pathway|cellular component movement|inflammatory response|keratinocyte differentiation|lipid metabolic process|peptide cross-linking|positive regulation of vesicle fusion	basolateral plasma membrane|cilium|cornified envelope|cytoplasm|extracellular region|nucleus	calcium ion binding|calcium-dependent phospholipid binding|phospholipase A2 inhibitor activity|protein binding, bridging|receptor binding|structural molecule activity			breast(1)|central_nervous_system(1)	2		all_epithelial(88;2.54e-11)		OV - Ovarian serous cystadenocarcinoma(323;2.82e-06)|GBM - Glioblastoma multiforme(74;0.0325)	Alclometasone(DB00240)|Amcinonide(DB00288)|Beclomethasone(DB00394)|Betamethasone(DB00443)|Clobetasol(DB01013)|Clocortolone(DB00838)|Desonide(DB01260)|Desoximetasone(DB00547)|Dexamethasone(DB01234)|Diflorasone(DB00223)|Flumethasone Pivalate(DB00663)|Halobetasol Propionate(DB00596)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Loteprednol Etabonate(DB00873)|Methylprednisolone(DB00959)|Mometasone(DB00764)|Prednicarbate(DB01130)|Prednisone(DB00635)|Rimexolone(DB00896)|Triamcinolone(DB00620)													---	---	---	---
RORB	6096	broad.mit.edu	37	9	77257530	77257530	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:77257530G>A	uc004aji.2	+	4	518	c.469G>A	c.(469-471)GTC>ATC	p.V157I	RORB_uc004ajh.2_Missense_Mutation_p.V146I	NM_006914	NP_008845	Q92753	RORB_HUMAN	RAR-related orphan receptor B	157	Hinge (Potential).				eye photoreceptor cell development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(2)|lung(1)|skin(1)	4																		---	---	---	---
ZNF883	169834	broad.mit.edu	37	9	115759835	115759835	+	Silent	SNP	T	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:115759835T>C	uc011lwy.1	-	5	1944	c.705A>G	c.(703-705)AAA>AAG	p.K235K		NM_001101338	NP_001094808	P0CG24	ZN883_HUMAN	hypothetical protein LOC169834	235					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
TLR4	7099	broad.mit.edu	37	9	120475865	120475865	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:120475865T>G	uc004bjz.2	+	3	1750	c.1459T>G	c.(1459-1461)TTC>GTC	p.F487V	TLR4_uc004bka.2_Missense_Mutation_p.F447V|TLR4_uc004bkb.2_Missense_Mutation_p.F287V	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	487	LRR 15.|Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16																		---	---	---	---
FUT7	2529	broad.mit.edu	37	9	139925609	139925609	+	Silent	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139925609C>T	uc004ckq.2	-	2	1431	c.582G>A	c.(580-582)GCG>GCA	p.A194A	ABCA2_uc011mel.1_5'Flank|ABCA2_uc011mem.1_5'Flank|ABCA2_uc004ckl.1_5'Flank|ABCA2_uc004ckm.1_5'Flank|C9orf139_uc004ckp.1_Intron	NM_004479	NP_004470	Q11130	FUT7_HUMAN	fucosyltransferase 7	194	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity				0	all_cancers(76;0.0893)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.96e-05)|Epithelial(140;0.000486)														---	---	---	---
PLXDC2	84898	broad.mit.edu	37	10	20465939	20465939	+	Silent	SNP	A	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:20465939A>C	uc001iqg.1	+	8	1532	c.895A>C	c.(895-897)AGA>CGA	p.R299R	PLXDC2_uc001iqh.1_Silent_p.R250R|PLXDC2_uc009xkc.1_RNA	NM_032812	NP_116201	Q6UX71	PXDC2_HUMAN	plexin domain containing 2 precursor	299	Extracellular (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4																		---	---	---	---
GPR158	57512	broad.mit.edu	37	10	25701388	25701388	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:25701388T>G	uc001isj.2	+	4	1381	c.1321T>G	c.(1321-1323)TTT>GTT	p.F441V		NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	441	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8																		---	---	---	---
GPR158	57512	broad.mit.edu	37	10	25886999	25886999	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:25886999A>C	uc001isj.2	+	11	2504	c.2444A>C	c.(2443-2445)AAG>ACG	p.K815T	GPR158_uc001isk.2_Missense_Mutation_p.K190T	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	815	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8																		---	---	---	---
ARMC4	55130	broad.mit.edu	37	10	28250600	28250600	+	Missense_Mutation	SNP	G	A	A	rs138508233		TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:28250600G>A	uc009xky.2	-	10	1381	c.1283C>T	c.(1282-1284)TCA>TTA	p.S428L	ARMC4_uc010qds.1_5'UTR|ARMC4_uc010qdt.1_Missense_Mutation_p.S120L|ARMC4_uc001itz.2_Missense_Mutation_p.S428L|ARMC4_uc010qdu.1_Missense_Mutation_p.S120L	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	428							binding			ovary(4)|skin(2)	6																		---	---	---	---
PRKG1	5592	broad.mit.edu	37	10	54040702	54040702	+	Intron	SNP	T	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:54040702T>C	uc001jjm.2	+						PRKG1_uc001jjo.2_Intron|PRKG1_uc009xow.1_Intron|uc001jjq.1_Intron	NM_001098512	NP_001091982			protein kinase, cGMP-dependent, type I isoform						actin cytoskeleton organization|platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			lung(2)|stomach(1)|ovary(1)|central_nervous_system(1)|skin(1)	6		all_cancers(4;2.13e-08)|all_epithelial(4;2.44e-08)|all_lung(4;0.000173)		all cancers(4;1.18e-05)|GBM - Glioblastoma multiforme(4;0.000359)|Epithelial(53;0.00532)|Lung(62;0.0606)														---	---	---	---
CDH23	64072	broad.mit.edu	37	10	73544140	73544140	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:73544140G>A	uc001jrx.3	+	40	5842	c.5465G>A	c.(5464-5466)TGT>TAT	p.C1822Y		NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	1822	Cadherin 17.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11																		---	---	---	---
ZNF503	84858	broad.mit.edu	37	10	77158820	77158820	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:77158820G>A	uc001jxg.2	-	2	1964	c.1628C>T	c.(1627-1629)ACG>ATG	p.T543M	C10orf41_uc010qlf.1_5'Flank	NM_032772	NP_116161	Q96F45	ZN503_HUMAN	zinc finger protein 503	543					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1	all_cancers(46;0.105)|all_epithelial(25;0.00449)|Prostate(51;0.0112)|Ovarian(15;0.088)																	---	---	---	---
PYROXD2	84795	broad.mit.edu	37	10	100150465	100150465	+	Silent	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:100150465G>A	uc001kpc.2	-	12	1268	c.1182C>T	c.(1180-1182)CCC>CCT	p.P394P	PYROXD2_uc001kpb.2_RNA|PYROXD2_uc001kpd.2_RNA	NM_032709	NP_116098	Q8N2H3	PYRD2_HUMAN	pyridine nucleotide-disulphide oxidoreductase	394							oxidoreductase activity			central_nervous_system(1)	1																		---	---	---	---
OR51A7	119687	broad.mit.edu	37	11	4928970	4928970	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:4928970T>G	uc010qyq.1	+	1	371	c.371T>G	c.(370-372)CTT>CGT	p.L124R		NM_001004749	NP_001004749	Q8NH64	O51A7_HUMAN	olfactory receptor, family 51, subfamily A,	124	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)														---	---	---	---
OR52E8	390079	broad.mit.edu	37	11	5878173	5878173	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:5878173A>C	uc010qzr.1	-	1	760	c.760T>G	c.(760-762)TTA>GTA	p.L254V	TRIM5_uc001mbq.1_Intron	NM_001005168	NP_001005168	Q6IFG1	O52E8_HUMAN	olfactory receptor, family 52, subfamily E,	254	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.114)		Epithelial(150;2.37e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)														---	---	---	---
OR56A4	120793	broad.mit.edu	37	11	6023384	6023384	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:6023384T>G	uc010qzv.1	-	1	995	c.995A>C	c.(994-996)AAC>ACC	p.N332T		NM_001005179	NP_001005179	Q8NGH8	O56A4_HUMAN	olfactory receptor, family 56, subfamily A,	280	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)														---	---	---	---
LUZP2	338645	broad.mit.edu	37	11	25071622	25071622	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:25071622A>C	uc001mqs.2	+	10	1038	c.804A>C	c.(802-804)CAA>CAC	p.Q268H	LUZP2_uc009yif.2_Missense_Mutation_p.Q182H|LUZP2_uc009yig.2_Missense_Mutation_p.Q226H	NM_001009909	NP_001009909	Q86TE4	LUZP2_HUMAN	leucine zipper protein 2 precursor	268						extracellular region				ovary(1)|skin(1)	2																		---	---	---	---
DCDC1	341019	broad.mit.edu	37	11	31349807	31349807	+	Silent	SNP	T	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:31349807T>C	uc001msv.2	-	3	223	c.21A>G	c.(19-21)GAA>GAG	p.E7E	DCDC1_uc001msu.1_5'UTR	NM_181807	NP_861523	P59894	DCDC1_HUMAN	doublecortin domain containing 1	7					intracellular signal transduction					skin(1)	1	Lung SC(675;0.225)																	---	---	---	---
API5	8539	broad.mit.edu	37	11	43352073	43352073	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:43352073G>A	uc010rfh.1	+	11	1410	c.1237G>A	c.(1237-1239)GTT>ATT	p.V413I	API5_uc010rfg.1_Missense_Mutation_p.V402I|API5_uc001mxf.2_Missense_Mutation_p.V413I|API5_uc010rfi.1_Missense_Mutation_p.V359I|API5_uc001mxg.2_Missense_Mutation_p.V287I	NM_001142930	NP_001136402	Q9BZZ5	API5_HUMAN	apoptosis inhibitor 5 isoform a	413					anti-apoptosis|apoptosis	cytoplasm|spliceosomal complex	fibroblast growth factor binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3																		---	---	---	---
OR4A5	81318	broad.mit.edu	37	11	51412117	51412117	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:51412117T>G	uc001nhi.1	-	1	279	c.279A>C	c.(277-279)CAA>CAC	p.Q93H		NM_001005272	NP_001005272	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A,	93	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(304;0.236)																---	---	---	---
Unknown	0	broad.mit.edu	37	11	55322905	55322905	+	IGR	SNP	A	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55322905A>C								OR4C15 (12 upstream) : OR4C16 (16699 downstream)																																			---	---	---	---
OR5D18	219438	broad.mit.edu	37	11	55587102	55587102	+	5'Flank	SNP	A	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55587102A>C	uc010rin.1	+							NM_001001952	NP_001001952			olfactory receptor, family 5, subfamily D,						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)																---	---	---	---
SPRYD5	84767	broad.mit.edu	37	11	55657447	55657447	+	Missense_Mutation	SNP	A	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55657447A>T	uc010rip.1	+	6	883	c.791A>T	c.(790-792)GAG>GTG	p.E264V	SPRYD5_uc010riq.1_Missense_Mutation_p.E121V	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	264						intracellular	zinc ion binding				0		all_epithelial(135;0.226)																---	---	---	---
OR5W2	390148	broad.mit.edu	37	11	55681965	55681965	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55681965A>C	uc010rir.1	-	1	94	c.94T>G	c.(94-96)TTG>GTG	p.L32V		NM_001001960	NP_001001960	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W,	32	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2																		---	---	---	---
FAT3	120114	broad.mit.edu	37	11	92533859	92533859	+	Silent	SNP	G	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:92533859G>T	uc001pdj.3	+	9	7697	c.7680G>T	c.(7678-7680)CGG>CGT	p.R2560R		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2560	Cadherin 23.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)													TCGA Ovarian(4;0.039)			---	---	---	---
FAT3	120114	broad.mit.edu	37	11	92616488	92616488	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:92616488T>C	uc001pdj.3	+	23	12883	c.12866T>C	c.(12865-12867)CTC>CCC	p.L4289P	FAT3_uc001pdi.3_Missense_Mutation_p.L729P	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	4289	Cytoplasmic (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)													TCGA Ovarian(4;0.039)			---	---	---	---
DYNC2H1	79659	broad.mit.edu	37	11	103058272	103058272	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:103058272T>G	uc001pho.2	+	43	7241	c.7097T>G	c.(7096-7098)CTT>CGT	p.L2366R	DYNC2H1_uc001phn.1_Missense_Mutation_p.L2366R|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	2366	AAA 3 (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)														---	---	---	---
RAB39	54734	broad.mit.edu	37	11	107832831	107832831	+	Silent	SNP	T	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:107832831T>C	uc001pjt.2	+	2	405	c.387T>C	c.(385-387)TGT>TGC	p.C129C		NM_017516	NP_059986	Q14964	RB39A_HUMAN	RAB39, member RAS oncogene family	129	GTP (By similarity).				protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding				0				BRCA - Breast invasive adenocarcinoma(274;3.04e-05)|Epithelial(105;8.56e-05)|all cancers(92;0.00179)														---	---	---	---
CBL	867	broad.mit.edu	37	11	119170326	119170326	+	Silent	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:119170326C>T	uc001pwe.2	+	16	2694	c.2556C>T	c.(2554-2556)ACC>ACT	p.T852T		NM_005188	NP_005179	P22681	CBL_HUMAN	Cas-Br-M (murine) ecotropic retroviral	852	Interaction with CD2AP.				epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of receptor-mediated endocytosis	cytosol|nucleus	calcium ion binding|sequence-specific DNA binding transcription factor activity|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(135)|lung(10)|central_nervous_system(2)|ovary(1)|breast(1)	149		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.92e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.000784)										CBL_gene-associated_Juvenile_Myelomonocytic_Leukemia_and_Developmental_Anomalies|Noonan_syndrome				---	---	---	---
C11orf63	79864	broad.mit.edu	37	11	122775942	122775942	+	Intron	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:122775942T>G	uc001pym.2	+						C11orf63_uc001pyl.1_3'UTR	NM_024806	NP_079082			hypothetical protein LOC79864 isoform 1											ovary(3)	3		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)														---	---	---	---
CHD4	1108	broad.mit.edu	37	12	6702658	6702658	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:6702658C>T	uc001qpo.2	-	16	2602	c.2438G>A	c.(2437-2439)CGT>CAT	p.R813H	CHD4_uc001qpn.2_Missense_Mutation_p.R806H|CHD4_uc001qpp.2_Missense_Mutation_p.R810H	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	813	Helicase ATP-binding.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2																		---	---	---	---
LAG3	3902	broad.mit.edu	37	12	6883914	6883914	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:6883914C>T	uc001qqt.3	+	4	1014	c.665C>T	c.(664-666)GCG>GTG	p.A222V	LAG3_uc001qqs.2_Missense_Mutation_p.A222V|LAG3_uc001qqu.2_Missense_Mutation_p.A52V	NM_002286	NP_002277	P18627	LAG3_HUMAN	lymphocyte-activation protein 3 precursor	222	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane	antigen binding|MHC class II protein binding				0																		---	---	---	---
CLEC2B	9976	broad.mit.edu	37	12	10007076	10007076	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:10007076A>G	uc001qwn.2	-	4	902	c.245T>C	c.(244-246)CTT>CCT	p.L82P		NM_005127	NP_005118	Q92478	CLC2B_HUMAN	C-type lectin, superfamily member 2	82	C-type lectin.|Extracellular (Potential).					integral to plasma membrane	sugar binding				0																		---	---	---	---
KCNJ8	3764	broad.mit.edu	37	12	21919280	21919280	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:21919280T>G	uc001rff.2	-	3	990	c.652A>C	c.(652-654)AGC>CGC	p.S218R		NM_004982	NP_004973	Q15842	IRK8_HUMAN	potassium inwardly-rectifying channel J8	218	Cytoplasmic (By similarity).					voltage-gated potassium channel complex					0					Levosimendan(DB00922)													---	---	---	---
CMAS	55907	broad.mit.edu	37	12	22218129	22218129	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:22218129G>T	uc001rfm.2	+	8	1268	c.1189G>T	c.(1189-1191)GCC>TCC	p.A397S	CMAS_uc001rfn.2_RNA	NM_018686	NP_061156	Q8NFW8	NEUA_HUMAN	cytidine monophospho-N-acetylneuraminic acid	397					lipopolysaccharide biosynthetic process	nucleus	N-acylneuraminate cytidylyltransferase activity			ovary(1)|pancreas(1)|skin(1)	3																		---	---	---	---
FAR2	55711	broad.mit.edu	37	12	29449959	29449959	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:29449959C>T	uc001ris.3	+	4	518	c.371C>T	c.(370-372)GCT>GTT	p.A124V	FAR2_uc001rit.2_Missense_Mutation_p.A124V|FAR2_uc009zjm.2_Missense_Mutation_p.A27V|uc001riu.1_Intron	NM_018099	NP_060569	Q96K12	FACR2_HUMAN	fatty acyl CoA reductase 2	124					ether lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	binding|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor				0																		---	---	---	---
KIF21A	55605	broad.mit.edu	37	12	39705250	39705250	+	Silent	SNP	A	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:39705250A>G	uc001rly.2	-	32	4211	c.4065T>C	c.(4063-4065)TCT>TCC	p.S1355S	KIF21A_uc001rlv.2_Silent_p.S300S|KIF21A_uc001rlw.2_Silent_p.S625S|KIF21A_uc001rlx.2_Silent_p.S1342S|KIF21A_uc001rlz.2_Silent_p.S1302S|KIF21A_uc010skl.1_Silent_p.S1318S|KIF21A_uc001rlt.2_5'UTR|KIF21A_uc001rlu.2_5'UTR	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	1355	WD 1.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)																---	---	---	---
KIAA0748	9840	broad.mit.edu	37	12	55356738	55356738	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:55356738A>C	uc001sgn.3	-	9	1054	c.944T>G	c.(943-945)GTT>GGT	p.V315G	KIAA0748_uc001sgl.3_Missense_Mutation_p.V177G|KIAA0748_uc001sgm.3_Missense_Mutation_p.V62G|KIAA0748_uc010spb.1_Missense_Mutation_p.V62G|KIAA0748_uc010spc.1_Missense_Mutation_p.V177G|KIAA0748_uc010spd.1_Missense_Mutation_p.V315G|KIAA0748_uc001sgo.3_RNA	NM_001098815	NP_001092285	A2RU30	K0748_HUMAN	hypothetical protein LOC9840	315										ovary(1)|central_nervous_system(1)	2																		---	---	---	---
C12orf63	374467	broad.mit.edu	37	12	97045576	97045576	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:97045576A>C	uc001tet.1	+	3	436	c.358A>C	c.(358-360)AAT>CAT	p.N120H		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	120										skin(6)|ovary(1)	7																		---	---	---	---
ALDH1L2	160428	broad.mit.edu	37	12	105454748	105454748	+	Intron	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:105454748C>T	uc001tlc.2	-						ALDH1L2_uc009zuo.2_Intron|ALDH1L2_uc009zup.2_Intron	NM_001034173	NP_001029345			aldehyde dehydrogenase 1 family, member L2						10-formyltetrahydrofolate catabolic process|biosynthetic process	mitochondrion	acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity|phosphopantetheine binding			skin(1)	1																		---	---	---	---
NBEA	26960	broad.mit.edu	37	13	36141109	36141109	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:36141109A>C	uc001uvb.2	+	45	7196	c.6990A>C	c.(6988-6990)GAA>GAC	p.E2330D	NBEA_uc010abi.2_Missense_Mutation_p.E986D|NBEA_uc010tee.1_Missense_Mutation_p.E123D|NBEA_uc010tef.1_Missense_Mutation_p.E123D|NBEA_uc010teg.1_Missense_Mutation_p.E123D	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	2330	BEACH.					cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)														---	---	---	---
CCNA1	8900	broad.mit.edu	37	13	37012812	37012812	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:37012812A>C	uc001uvr.3	+	5	1051	c.701A>C	c.(700-702)AAG>ACG	p.K234T	CCNA1_uc010teo.1_Missense_Mutation_p.K190T|CCNA1_uc010abq.2_Missense_Mutation_p.K190T|CCNA1_uc010abp.2_Missense_Mutation_p.K190T|CCNA1_uc001uvs.3_Missense_Mutation_p.K233T|CCNA1_uc010abr.2_Intron	NM_003914	NP_003905	P78396	CCNA1_HUMAN	cyclin A1 isoform a	234					cell division|G2/M transition of mitotic cell cycle|male meiosis I|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|spermatogenesis	cytosol|microtubule cytoskeleton|nucleoplasm	protein kinase binding			lung(2)|skin(2)|ovary(1)	5		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.91e-07)|Epithelial(112;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0119)|GBM - Glioblastoma multiforme(144;0.0242)														---	---	---	---
SMAD9	4093	broad.mit.edu	37	13	37453530	37453530	+	Silent	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:37453530C>T	uc001uvw.2	-	2	640	c.297G>A	c.(295-297)CCG>CCA	p.P99P	SMAD9_uc001uvx.2_Silent_p.P99P|SMAD9_uc010tep.1_5'UTR	NM_001127217	NP_001120689	O15198	SMAD9_HUMAN	SMAD family member 9 isoform a	99	MH1.				BMP signaling pathway|transforming growth factor beta receptor signaling pathway	cytosol|transcription factor complex	sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity				0		Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)		all cancers(112;3.38e-07)|Epithelial(112;1.93e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00804)|BRCA - Breast invasive adenocarcinoma(63;0.0129)|GBM - Glioblastoma multiforme(144;0.026)														---	---	---	---
EXOSC8	11340	broad.mit.edu	37	13	37580169	37580169	+	Intron	SNP	G	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:37580169G>C	uc001uwa.2	+						EXOSC8_uc001uvz.2_Intron|EXOSC8_uc001uwb.2_Intron|EXOSC8_uc001uwc.2_Intron	NM_181503	NP_852480			exosome component 8						exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA processing	cytosol|exosome (RNase complex)|nucleolus	AU-rich element binding|identical protein binding			pancreas(1)	1		Lung NSC(96;6.57e-05)|Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)		all cancers(112;3.67e-07)|Epithelial(112;1.31e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00699)|BRCA - Breast invasive adenocarcinoma(63;0.0117)|GBM - Glioblastoma multiforme(144;0.0411)														---	---	---	---
TRPC4	7223	broad.mit.edu	37	13	38229268	38229268	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:38229268T>G	uc001uws.2	-	7	2076	c.1841A>C	c.(1840-1842)AAC>ACC	p.N614T	TRPC4_uc010abv.2_Missense_Mutation_p.N194T|TRPC4_uc001uwt.2_Missense_Mutation_p.N614T|TRPC4_uc010tey.1_Missense_Mutation_p.N614T|TRPC4_uc010abw.2_Missense_Mutation_p.N441T|TRPC4_uc010abx.2_Missense_Mutation_p.N614T|TRPC4_uc010aby.2_Missense_Mutation_p.N614T	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	614	Helical; (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)														---	---	---	---
AKAP11	11215	broad.mit.edu	37	13	42878011	42878011	+	Intron	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:42878011G>A	uc001uys.1	+							NM_016248	NP_057332			A-kinase anchor protein 11						intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)														---	---	---	---
ZC3H13	23091	broad.mit.edu	37	13	46554086	46554086	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:46554086A>C	uc010tfw.1	-	10	1780	c.1774T>G	c.(1774-1776)TAT>GAT	p.Y592D	ZC3H13_uc001vas.1_Missense_Mutation_p.Y592D|ZC3H13_uc001vat.1_Missense_Mutation_p.Y592D	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	592	Arg/Ser-rich.						nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)														---	---	---	---
C13orf18	80183	broad.mit.edu	37	13	46946186	46946186	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:46946186G>A	uc010acl.2	-	3	1030	c.425C>T	c.(424-426)TCT>TTT	p.S142F	C13orf18_uc001vbf.3_Missense_Mutation_p.S75F|C13orf18_uc001vbg.3_5'UTR|C13orf18_uc010tfz.1_Intron|C13orf18_uc010acm.2_Missense_Mutation_p.S7F|C13orf18_uc010acn.2_Intron|C13orf18_uc001vbe.3_Missense_Mutation_p.S142F|C13orf18_uc001vbh.3_Missense_Mutation_p.S142F|C13orf18_uc001vbi.3_Intron|C13orf18_uc010aco.1_Missense_Mutation_p.S142F|C13orf18_uc010tga.1_Missense_Mutation_p.S75F	NM_025113	NP_079389	Q9H714	CM018_HUMAN	hypothetical protein LOC80183	142											0		Lung NSC(96;2.31e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;2.19e-05)														---	---	---	---
ITM2B	9445	broad.mit.edu	37	13	48835306	48835306	+	Silent	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:48835306C>T	uc001vbz.3	+	6	970	c.747C>T	c.(745-747)TTC>TTT	p.F249F		NM_021999	NP_068839	Q9Y287	ITM2B_HUMAN	integral membrane protein 2B	249	Lumenal (Potential).				nervous system development	Golgi membrane|integral to membrane|nucleus|plasma membrane	beta-amyloid binding				0		all_cancers(8;2.2e-31)|all_epithelial(8;6.77e-15)|all_lung(13;9.67e-07)|all_hematologic(8;9.72e-06)|Lung NSC(96;8.3e-05)|Breast(56;0.000141)|Acute lymphoblastic leukemia(8;0.00045)|Prostate(109;0.000669)|Myeloproliferative disorder(33;0.039)|Hepatocellular(98;0.0556)|Lung SC(185;0.102)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(144;1.97e-06)														---	---	---	---
PCDH9	5101	broad.mit.edu	37	13	66878826	66878826	+	Silent	SNP	T	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:66878826T>C	uc001vik.2	-	5	4367	c.3675A>G	c.(3673-3675)GCA>GCG	p.A1225A	PCDH9_uc010aei.2_RNA|PCDH9_uc001vil.2_Silent_p.A1191A|PCDH9_uc010thl.1_Silent_p.A1183A	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	1225	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)														---	---	---	---
SLITRK6	84189	broad.mit.edu	37	13	86368894	86368894	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:86368894C>T	uc001vll.1	-	2	2209	c.1750G>A	c.(1750-1752)GTC>ATC	p.V584I	SLITRK6_uc010afe.1_Intron	NM_032229	NP_115605	Q9H5Y7	SLIK6_HUMAN	slit and trk like 6 precursor	584	Extracellular (Potential).					integral to membrane				large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)														---	---	---	---
NALCN	259232	broad.mit.edu	37	13	101710377	101710377	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:101710377G>A	uc001vox.1	-	43	5126	c.4937C>T	c.(4936-4938)ACG>ATG	p.T1646M		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	1646	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)																	---	---	---	---
MYH6	4624	broad.mit.edu	37	14	23874326	23874326	+	Silent	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:23874326G>A	uc001wjv.2	-	6	580	c.513C>T	c.(511-513)AAC>AAT	p.N171N	MYH6_uc010akp.1_Silent_p.N171N	NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	171	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)														---	---	---	---
NOVA1	4857	broad.mit.edu	37	14	26918125	26918125	+	Silent	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:26918125C>T	uc001wpy.2	-	5	882	c.564G>A	c.(562-564)GGG>GGA	p.G188G	NOVA1_uc001wpz.2_Silent_p.G164G|NOVA1_uc001wqa.2_Silent_p.G66G	NM_002515	NP_002506	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1 isoform 1	191	KH 2.				locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			skin(2)|upper_aerodigestive_tract(1)|breast(1)|liver(1)	5				GBM - Glioblastoma multiforme(265;0.0135)														---	---	---	---
TMEM63C	57156	broad.mit.edu	37	14	77710688	77710688	+	Intron	SNP	G	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:77710688G>T	uc001xtf.2	+						TMEM63C_uc010asq.1_Intron	NM_020431	NP_065164			transmembrane protein 63C							integral to membrane					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0342)														---	---	---	---
Unknown	0	broad.mit.edu	37	15	22466372	22466372	+	5'Flank	SNP	A	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:22466372A>C	uc001yui.1	-											Homo sapiens clone IgA5728-2 immunoglobulin A heavy chain mRNA, partial cds.																														---	---	---	---
SNRPN	6638	broad.mit.edu	37	15	25220656	25220656	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:25220656A>C	uc001ywp.1	+	8	1045	c.155A>C	c.(154-156)AAG>ACG	p.K52T	SNRPN_uc001ywq.1_Missense_Mutation_p.K52T|SNRPN_uc001ywr.1_Missense_Mutation_p.K52T|SNRPN_uc001yws.1_Missense_Mutation_p.K52T|SNRPN_uc001ywt.1_Missense_Mutation_p.K52T|SNRPN_uc001ywv.1_Missense_Mutation_p.K55T|SNRPN_uc001yww.1_Missense_Mutation_p.K52T|SNRPN_uc001ywx.1_Missense_Mutation_p.K52T|SNRPN_uc001ywz.1_Intron|PAR-SN_uc001yxa.1_Intron|SNRPN_uc001ywy.1_3'UTR	NM_022807	NP_073718	P63162	RSMN_HUMAN	small nuclear ribonucleoprotein polypeptide N	52					RNA splicing	small nuclear ribonucleoprotein complex|spliceosomal complex	identical protein binding|RNA binding			ovary(1)	1		all_cancers(20;9.33e-22)|Breast(32;0.000625)		all cancers(64;3.38e-08)|Epithelial(43;3.45e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000207)|GBM - Glioblastoma multiforme(186;0.125)										Prader-Willi_syndrome				---	---	---	---
Unknown	0	broad.mit.edu	37	15	25492563	25492563	+	Intron	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:25492563C>T	uc001zae.2	+						SNORD115-10_uc001zak.1_RNA|SNORD115-11_uc001zal.1_5'Flank					Homo sapiens clone Rt-16 SNURF-SNRPN mRNA, downstream untranslated exons, alternatively spliced.																														---	---	---	---
GABRA5	2558	broad.mit.edu	37	15	27128556	27128556	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:27128556C>T	uc001zbd.1	+	7	688	c.349C>T	c.(349-351)CGC>TGC	p.R117C	GABRB3_uc001zbb.2_Intron	NM_000810	NP_000801	P31644	GBRA5_HUMAN	gamma-aminobutyric acid A receptor, alpha 5	117	Extracellular (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(1)	1		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)													---	---	---	---
RYR3	6263	broad.mit.edu	37	15	33905387	33905387	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:33905387G>A	uc001zhi.2	+	19	2238	c.2168G>A	c.(2167-2169)CGG>CAG	p.R723Q	RYR3_uc010bar.2_Missense_Mutation_p.R723Q	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	723	Cytoplasmic (By similarity).|B30.2/SPRY 1.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)														---	---	---	---
RPUSD2	27079	broad.mit.edu	37	15	40866003	40866003	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:40866003G>A	uc001zmd.1	+	3	1181	c.1181G>A	c.(1180-1182)TGG>TAG	p.W394*		NM_152260	NP_689473	Q8IZ73	RUSD2_HUMAN	RNA pseudouridylate synthase domain containing	394					pseudouridine synthesis		protein binding|pseudouridine synthase activity|RNA binding			skin(1)	1		all_cancers(109;2.74e-14)|all_epithelial(112;1.64e-11)|Lung NSC(122;6.69e-09)|all_lung(180;1.22e-07)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3.1e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0786)														---	---	---	---
SECISBP2L	9728	broad.mit.edu	37	15	49325260	49325260	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:49325260G>A	uc001zxe.1	-	4	700	c.566C>T	c.(565-567)CCG>CTG	p.P189L	SECISBP2L_uc001zxd.1_Missense_Mutation_p.P189L|SECISBP2L_uc010bep.1_5'UTR|SECISBP2L_uc010beq.1_Missense_Mutation_p.P189L	NM_014701	NP_055516	Q93073	SBP2L_HUMAN	SECIS binding protein 2-like	189										breast(1)|skin(1)	2																		---	---	---	---
ATP8B4	79895	broad.mit.edu	37	15	50189507	50189507	+	Silent	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:50189507G>A	uc001zxu.2	-	23	2821	c.2679C>T	c.(2677-2679)TTC>TTT	p.F893F	ATP8B4_uc010ber.2_Silent_p.F766F|ATP8B4_uc010ufd.1_Silent_p.F703F|ATP8B4_uc010ufe.1_RNA|ATP8B4_uc001zxv.1_Silent_p.F191F	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	893	Extracellular (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)														---	---	---	---
RASGRF1	5923	broad.mit.edu	37	15	79356827	79356827	+	Silent	SNP	G	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:79356827G>T	uc002beq.2	-	2	693	c.318C>A	c.(316-318)GCC>GCA	p.A106A	RASGRF1_uc002bep.2_Silent_p.A106A|RASGRF1_uc010blm.1_Silent_p.A28A|RASGRF1_uc002ber.3_Silent_p.A106A	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Ras protein-specific guanine	106	PH 1.				activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			skin(4)|ovary(1)|central_nervous_system(1)	6																		---	---	---	---
GRIN2A	2903	broad.mit.edu	37	16	9857275	9857275	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:9857275G>A	uc002czo.3	-	13	4674	c.4126C>T	c.(4126-4128)CGC>TGC	p.R1376C	GRIN2A_uc010uym.1_Missense_Mutation_p.R1376C|GRIN2A_uc010uyn.1_Silent_p.N1104N|GRIN2A_uc002czr.3_Silent_p.N1261N	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1376	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)													---	---	---	---
IL21R	50615	broad.mit.edu	37	16	27460390	27460390	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:27460390G>A	uc002doq.1	+	9	1636	c.1403G>A	c.(1402-1404)CGG>CAG	p.R468Q	IL21R_uc002dor.1_Missense_Mutation_p.R468Q|IL21R_uc002dos.1_Missense_Mutation_p.R468Q|uc002dot.2_RNA	NM_181078	NP_851564	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor precursor	468	Cytoplasmic (Potential).				natural killer cell activation	integral to membrane	interleukin-21 receptor activity			ovary(2)|lung(1)|breast(1)	4								T	BCL6	NHL								---	---	---	---
SRCAP	10847	broad.mit.edu	37	16	30727524	30727524	+	Splice_Site	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:30727524G>A	uc002dze.1	+	17	3015	c.2630_splice	c.e17+1	p.T877_splice	SRCAP_uc002dzf.2_Splice_Site|SRCAP_uc002dzg.1_Splice_Site_p.T734_splice|SRCAP_uc010bzz.1_Splice_Site_p.T447_splice	NM_006662	NP_006653			Snf2-related CBP activator protein						interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)															---	---	---	---
MYST1	84148	broad.mit.edu	37	16	31131665	31131665	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:31131665C>T	uc002eay.2	+	3	310	c.292C>T	c.(292-294)CGG>TGG	p.R98W	MYST1_uc002eax.2_Missense_Mutation_p.R98W	NM_032188	NP_115564	Q9H7Z6	MYST1_HUMAN	MYST histone acetyltransferase 1 isoform 1	98	Chromo.				histone H4-K16 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex|MSL complex	histone acetyltransferase activity|metal ion binding|methylated histone residue binding|transcription factor binding			ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	16	33647269	33647269	+	IGR	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:33647269C>T								SLC6A10P (750806 upstream) : MIR1826 (318239 downstream)																																			---	---	---	---
WWP2	11060	broad.mit.edu	37	16	69922098	69922098	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:69922098C>T	uc002exu.1	+	9	949	c.860C>T	c.(859-861)TCG>TTG	p.S287L	WWP2_uc002ext.2_Missense_Mutation_p.S287L|WWP2_uc002exv.1_Missense_Mutation_p.S287L|WWP2_uc010vlm.1_Missense_Mutation_p.S171L	NM_007014	NP_008945	O00308	WWP2_HUMAN	WW domain containing E3 ubiquitin protein ligase	287					entry of virus into host cell|negative regulation of protein transport|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transporter activity|proteasomal ubiquitin-dependent protein catabolic process|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	RNA polymerase II transcription factor binding|ubiquitin-protein ligase activity			lung(3)|ovary(1)|breast(1)|skin(1)	6																		---	---	---	---
ITGAE	3682	broad.mit.edu	37	17	3631275	3631275	+	Missense_Mutation	SNP	A	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:3631275A>T	uc002fwo.3	-	26	3121	c.3022T>A	c.(3022-3024)TGC>AGC	p.C1008S		NM_002208	NP_002199	P38570	ITAE_HUMAN	integrin, alpha E precursor	1008	Extracellular (Potential).				cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			large_intestine(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)														---	---	---	---
KCNAB3	9196	broad.mit.edu	37	17	7826435	7826435	+	Silent	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7826435C>T	uc002gjm.1	-	14	1200	c.1200G>A	c.(1198-1200)CCG>CCA	p.P400P	KCNAB3_uc010vul.1_RNA	NM_004732	NP_004723	O43448	KCAB3_HUMAN	potassium voltage-gated channel, shaker-related	400						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			ovary(1)	1		Prostate(122;0.157)																---	---	---	---
TEKT3	64518	broad.mit.edu	37	17	15211982	15211982	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:15211982G>A	uc002gon.2	-	8	1442	c.1255C>T	c.(1255-1257)CGC>TGC	p.R419C		NM_031898	NP_114104	Q9BXF9	TEKT3_HUMAN	tektin 3	419	Potential.				microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0877)														---	---	---	---
SEZ6	124925	broad.mit.edu	37	17	27283167	27283167	+	Intron	SNP	G	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:27283167G>T	uc002hdp.2	-						SEZ6_uc010crx.1_Intron|SEZ6_uc002hdm.2_Intron|SEZ6_uc010cry.1_Intron|SEZ6_uc002hdq.1_Intron	NM_178860	NP_849191			seizure related 6 homolog isoform 1							integral to membrane|plasma membrane				large_intestine(1)|central_nervous_system(1)	2	Lung NSC(42;0.0137)		Epithelial(11;4.73e-06)|all cancers(11;2.91e-05)|BRCA - Breast invasive adenocarcinoma(11;8.06e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.111)															---	---	---	---
UNC45B	146862	broad.mit.edu	37	17	33495277	33495277	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:33495277C>T	uc002hja.2	+	10	1446	c.1349C>T	c.(1348-1350)ACG>ATG	p.T450M	UNC45B_uc002hjb.2_Missense_Mutation_p.T450M|UNC45B_uc002hjc.2_Missense_Mutation_p.T450M|UNC45B_uc010cto.2_Missense_Mutation_p.T450M	NM_173167	NP_775259	Q8IWX7	UN45B_HUMAN	cardiomyopathy associated 4 isoform 1	450					cell differentiation|muscle organ development	cytosol	binding			ovary(3)|central_nervous_system(2)|breast(1)	6		Ovarian(249;0.17)																---	---	---	---
TMEM99	147184	broad.mit.edu	37	17	38990822	38990822	+	Silent	SNP	T	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:38990822T>C	uc002hvj.1	+	3	361	c.54T>C	c.(52-54)TGT>TGC	p.C18C		NM_145274	NP_660317	Q8N816	TMM99_HUMAN	transmembrane protein 99 precursor	18						integral to membrane				skin(1)	1		Breast(137;0.000301)																---	---	---	---
KIF2B	84643	broad.mit.edu	37	17	51901928	51901928	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:51901928T>G	uc002iua.2	+	1	1690	c.1534T>G	c.(1534-1536)TCC>GCC	p.S512A	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	512					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8																		---	---	---	---
RNF43	54894	broad.mit.edu	37	17	56448390	56448390	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:56448390T>C	uc002iwf.2	-	2	2213	c.257A>G	c.(256-258)CAC>CGC	p.H86R	RNF43_uc010wnv.1_Intron|RNF43_uc002iwh.3_Missense_Mutation_p.H86R|RNF43_uc002iwg.3_Missense_Mutation_p.H86R|RNF43_uc010dcw.2_5'UTR	NM_017763	NP_060233	Q68DV7	RNF43_HUMAN	ring finger protein 43 precursor	86	Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			ovary(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)																	---	---	---	---
CCDC46	201134	broad.mit.edu	37	17	64059183	64059183	+	Silent	SNP	A	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:64059183A>C	uc002jfl.2	-	11	1191	c.972T>G	c.(970-972)CGT>CGG	p.R324R	CCDC46_uc010deo.2_Silent_p.R66R|CCDC46_uc002jfm.2_Silent_p.R324R|CCDC46_uc010dep.2_Silent_p.R282R	NM_145036	NP_659473	Q8N8E3	CE112_HUMAN	coiled-coil domain containing 46 isoform a	324	Potential.					centrosome					0			BRCA - Breast invasive adenocarcinoma(6;1.53e-06)															---	---	---	---
ABCA5	23461	broad.mit.edu	37	17	67300886	67300886	+	Missense_Mutation	SNP	G	A	A	rs140650277	byFrequency	TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:67300886G>A	uc002jif.2	-	6	2072	c.854C>T	c.(853-855)GCG>GTG	p.A285V	ABCA5_uc002jie.2_5'Flank|ABCA5_uc002jig.2_Missense_Mutation_p.A285V|ABCA5_uc002jih.2_Missense_Mutation_p.A285V|ABCA5_uc010dfe.2_Missense_Mutation_p.A285V	NM_018672	NP_061142	Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A , member 5	285					cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;3.72e-11)																	---	---	---	---
C17orf77	146723	broad.mit.edu	37	17	72584997	72584997	+	Intron	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:72584997C>T	uc002jla.1	+						CD300LD_uc002jkz.2_Intron	NM_152460	NP_689673			hypothetical protein LOC146723							extracellular region					0																		---	---	---	---
ITGB4	3691	broad.mit.edu	37	17	73727404	73727404	+	Silent	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73727404C>T	uc002jpg.2	+	10	1357	c.1170C>T	c.(1168-1170)TTC>TTT	p.F390F	ITGB4_uc002jph.2_Silent_p.F390F|ITGB4_uc010dgo.2_Silent_p.F390F|ITGB4_uc002jpi.3_Silent_p.F390F|ITGB4_uc010dgp.1_Silent_p.F390F|ITGB4_uc002jpj.2_Silent_p.F390F|ITGB4_uc010wsh.1_5'Flank	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	390	Extracellular (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)															---	---	---	---
UBE2O	63893	broad.mit.edu	37	17	74396572	74396572	+	Silent	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:74396572C>T	uc002jrm.3	-	7	1019	c.954G>A	c.(952-954)ACG>ACA	p.T318T	UBE2O_uc002jrn.3_Silent_p.T318T|UBE2O_uc002jrl.3_5'Flank	NM_022066	NP_071349	Q9C0C9	UBE2O_HUMAN	ubiquitin-conjugating enzyme E2O	318							ATP binding|ubiquitin-protein ligase activity			breast(2)|skin(2)|lung(1)	5																		---	---	---	---
Unknown	0	broad.mit.edu	37	17	78282836	78282836	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:78282836G>T	uc002jyf.2	+	14	2663	c.2520G>T	c.(2518-2520)TTG>TTT	p.L840F	uc002jyg.1_Missense_Mutation_p.L571F	NM_020954	NP_066005			hypothetical protein LOC57714																														---	---	---	---
COLEC12	81035	broad.mit.edu	37	18	333120	333120	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:333120A>C	uc002kkm.2	-	7	2055	c.1840T>G	c.(1840-1842)TTC>GTC	p.F614V		NM_130386	NP_569057	Q5KU26	COL12_HUMAN	collectin sub-family member 12	614	Extracellular (Potential).|C-type lectin.				carbohydrate mediated signaling|innate immune response|phagocytosis, recognition|protein homooligomerization	collagen|integral to membrane	galactose binding|low-density lipoprotein particle binding|metal ion binding|pattern recognition receptor activity|scavenger receptor activity			ovary(1)|pancreas(1)	2		all_cancers(4;0.0442)|Myeloproliferative disorder(11;0.0426)																---	---	---	---
LAMA1	284217	broad.mit.edu	37	18	7050779	7050779	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:7050779T>C	uc002knm.2	-	4	596	c.502A>G	c.(502-504)AGA>GGA	p.R168G	LAMA1_uc010wzj.1_5'UTR	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	168	Laminin N-terminal.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
LRRC30	339291	broad.mit.edu	37	18	7231390	7231390	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:7231390T>G	uc010wzk.1	+	1	254	c.254T>G	c.(253-255)GTT>GGT	p.V85G		NM_001105581	NP_001099051	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	85	LRR 1.									ovary(1)|liver(1)	2																		---	---	---	---
ASXL3	80816	broad.mit.edu	37	18	31319840	31319840	+	Silent	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:31319840G>A	uc010dmg.1	+	11	2527	c.2472G>A	c.(2470-2472)CCG>CCA	p.P824P	ASXL3_uc002kxq.2_Silent_p.P531P	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	824					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3																		---	---	---	---
RIT2	6014	broad.mit.edu	37	18	40323518	40323518	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:40323518T>G	uc002lav.2	-	5	767	c.594A>C	c.(592-594)AAA>AAC	p.K198N	RIT2_uc010dnf.2_3'UTR	NM_002930	NP_002921	Q99578	RIT2_HUMAN	Ras-like without CAAX 2	198					nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction|synaptic transmission	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity			ovary(1)	1																		---	---	---	---
MUC16	94025	broad.mit.edu	37	19	9086015	9086015	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9086015A>C	uc002mkp.2	-	1	6004	c.5800T>G	c.(5800-5802)TTA>GTA	p.L1934V		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1934	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57																		---	---	---	---
COL5A3	50509	broad.mit.edu	37	19	10091541	10091541	+	Intron	SNP	C	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10091541C>A	uc002mmq.1	-							NM_015719	NP_056534			collagen, type V, alpha 3 preproprotein						collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)															---	---	---	---
CPAMD8	27151	broad.mit.edu	37	19	17091456	17091456	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17091456G>A	uc002nfb.2	-	14	1609	c.1577C>T	c.(1576-1578)CCC>CTC	p.P526L		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	479						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13																		---	---	---	---
CILP2	148113	broad.mit.edu	37	19	19655627	19655627	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19655627T>C	uc002nmv.3	+	8	2358	c.2273T>C	c.(2272-2274)GTG>GCG	p.V758A	CILP2_uc002nmw.3_Missense_Mutation_p.V764A	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	758						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1																		---	---	---	---
ZNF486	90649	broad.mit.edu	37	19	20308606	20308606	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:20308606T>C	uc002nou.2	+	4	1144	c.1087T>C	c.(1087-1089)TCA>CCA	p.S363P		NM_052852	NP_443084	Q96H40	ZN486_HUMAN	zinc finger protein 486	363	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1																		---	---	---	---
ZNF43	7594	broad.mit.edu	37	19	21992583	21992583	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:21992583A>C	uc002nqj.2	-	4	386	c.256T>G	c.(256-258)TTT>GTT	p.F86V	ZNF43_uc010ecv.2_Missense_Mutation_p.F80V|ZNF43_uc002nql.2_Missense_Mutation_p.F80V|ZNF43_uc002nqm.2_Missense_Mutation_p.F80V|ZNF43_uc002nqk.2_Missense_Mutation_p.F16V	NM_003423	NP_003414	P17038	ZNF43_HUMAN	zinc finger protein 43	86					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)														---	---	---	---
ZNF257	113835	broad.mit.edu	37	19	22272248	22272248	+	3'UTR	SNP	A	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:22272248A>C	uc010ecx.2	+	4					ZNF257_uc010ecy.2_3'UTR	NM_033468	NP_258429			zinc finger protein 257						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.0961)|Lung NSC(12;0.103)																---	---	---	---
ZNF99	7652	broad.mit.edu	37	19	22941726	22941726	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:22941726T>C	uc010xrh.1	-	5	712	c.712A>G	c.(712-714)AGA>GGA	p.R238G		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)																---	---	---	---
CEBPA	1050	broad.mit.edu	37	19	33792337	33792337	+	Silent	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:33792337C>T	uc002nun.2	-	1	1094	c.984G>A	c.(982-984)GTG>GTA	p.V328V	LOC80054_uc002nuo.2_5'Flank	NM_004364	NP_004355	P49715	CEBPA_HUMAN	CCAAT/enhancer binding protein alpha	328	Leucine-zipper.				cytokine-mediated signaling pathway|generation of precursor metabolites and energy|interspecies interaction between organisms|positive regulation of transcription from RNA polymerase III promoter		sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription factor binding|transcription regulatory region DNA binding	p.D322_V328del(1)|p.H200_K352>Q(1)|p.?(1)		haematopoietic_and_lymphoid_tissue(728)|lung(4)|stomach(1)|prostate(1)	734	Esophageal squamous(110;0.137)							Mis|N|F		AML|MDS				Acute_Myeloid_Leukemia_Familial_associated_with_CEBPA_germline_mutation				---	---	---	---
SNRPA	6626	broad.mit.edu	37	19	41263238	41263238	+	Missense_Mutation	SNP	G	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41263238G>C	uc002ooz.2	+	2	610	c.75G>C	c.(73-75)GAG>GAC	p.E25D	SNRPA_uc002opa.2_5'UTR	NM_004596	NP_004587	P09012	SNRPA_HUMAN	small nuclear ribonucleoprotein polypeptide A	25	RRM 1.					nucleoplasm|spliceosomal complex	nucleotide binding|protein binding|RNA binding			skin(2)|ovary(1)|central_nervous_system(1)	4			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)															---	---	---	---
CEACAM3	1084	broad.mit.edu	37	19	42301736	42301736	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42301736G>A	uc002orn.1	+	2	356	c.280G>A	c.(280-282)GCA>ACA	p.A94T	CEACAM3_uc010eia.1_Missense_Mutation_p.A94T|CEACAM3_uc002oro.1_RNA	NM_001815	NP_001806	P40198	CEAM3_HUMAN	carcinoembryonic antigen-related cell adhesion	94	Ig-like V-type.|Extracellular (Potential).					integral to membrane				skin(1)	1																		---	---	---	---
PSG5	5673	broad.mit.edu	37	19	43680148	43680148	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:43680148G>A	uc002ovu.2	-	3	714	c.583C>T	c.(583-585)CGA>TGA	p.R195*	PSG6_uc010xwk.1_Intron|PSG5_uc010eir.2_Intron|PSG5_uc002ovx.2_Nonsense_Mutation_p.R195*|PSG5_uc002ovv.2_Nonsense_Mutation_p.R288*|PSG5_uc002ovw.2_Intron	NM_002781	NP_002772	Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	195	Ig-like C2-type 1.			R -> Q (in Ref. 1; no nucleotide entry and 5; AAH12607).	female pregnancy	extracellular region				skin(3)	3		Prostate(69;0.00899)																---	---	---	---
FPR2	2358	broad.mit.edu	37	19	52272262	52272262	+	Silent	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:52272262T>G	uc002pxr.2	+	2	396	c.351T>G	c.(349-351)GGT>GGG	p.G117G	FPR2_uc002pxs.3_Silent_p.G117G|FPR2_uc010epf.2_Silent_p.G117G	NM_001005738	NP_001005738	P25090	FPR2_HUMAN	formyl peptide receptor-like 1	117	Helical; Name=3; (Potential).				cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity			lung(3)|ovary(1)	4																		---	---	---	---
ZNF649	65251	broad.mit.edu	37	19	52394692	52394692	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:52394692G>A	uc002pxy.2	-	5	965	c.697C>T	c.(697-699)CCC>TCC	p.P233S	ZNF577_uc010ydf.1_5'Flank	NM_023074	NP_075562	Q9BS31	ZN649_HUMAN	zinc finger protein 649	233					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)														---	---	---	---
NLRP7	199713	broad.mit.edu	37	19	55450806	55450806	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55450806T>G	uc002qih.3	-	4	1457	c.1381A>C	c.(1381-1383)AAA>CAA	p.K461Q	NLRP7_uc002qig.3_Missense_Mutation_p.K461Q|NLRP7_uc002qii.3_Missense_Mutation_p.K461Q|NLRP7_uc010esk.2_Missense_Mutation_p.K461Q|NLRP7_uc010esl.2_Missense_Mutation_p.K489Q	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	461	NACHT.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)														---	---	---	---
SLC32A1	140679	broad.mit.edu	37	20	37356678	37356678	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:37356678C>T	uc002xjc.2	+	2	1237	c.974C>T	c.(973-975)TCG>TTG	p.S325L		NM_080552	NP_542119	Q9H598	VIAAT_HUMAN	solute carrier family 32, member 1	325	Helical; (Potential).				neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity				0		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)													---	---	---	---
C20orf107	388799	broad.mit.edu	37	20	55111221	55111221	+	Intron	SNP	T	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:55111221T>C	uc010zzh.1	+						C20orf107_uc002xxz.2_Intron	NM_001013646	NP_001013668			hypothetical protein LOC388799 precursor							integral to membrane					0			Colorectal(105;0.202)															---	---	---	---
TPTE	7179	broad.mit.edu	37	21	10951257	10951257	+	Intron	SNP	C	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:10951257C>A	uc002yip.1	-						TPTE_uc002yis.1_Intron|TPTE_uc002yiq.1_Intron|TPTE_uc002yir.1_Intron|TPTE_uc010gkv.1_Intron	NM_199261	NP_954870			transmembrane phosphatase with tensin homology						signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)														---	---	---	---
ADRBK2	157	broad.mit.edu	37	22	26100174	26100174	+	Silent	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:26100174C>T	uc003abx.3	+	15	1473	c.1326C>T	c.(1324-1326)GGC>GGT	p.G442G	ADRBK2_uc010gux.2_Silent_p.G442G|ADRBK2_uc003abw.2_Silent_p.G329G|ADRBK2_uc003aby.3_RNA	NM_005160	NP_005151	P35626	ARBK2_HUMAN	beta-adrenergic receptor kinase 2	442	Protein kinase.						ATP binding|beta-adrenergic receptor kinase activity|signal transducer activity			lung(3)|ovary(2)|stomach(1)|central_nervous_system(1)	7					Adenosine triphosphate(DB00171)													---	---	---	---
ZMAT5	55954	broad.mit.edu	37	22	30136716	30136716	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:30136716T>G	uc003agm.2	-	5	445	c.194A>C	c.(193-195)CAG>CCG	p.Q65P	ZMAT5_uc003agn.2_Missense_Mutation_p.Q65P	NM_019103	NP_061976	Q9UDW3	ZMAT5_HUMAN	zinc finger, matrin type 5	65	C3H1-type.				mRNA processing	cytoplasm|U12-type spliceosomal complex	nucleic acid binding|zinc ion binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(5;0.000597)|all cancers(5;0.0534)|Epithelial(10;0.0574)															---	---	---	---
TMPRSS6	164656	broad.mit.edu	37	22	37482353	37482353	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:37482353C>T	uc003aqs.1	-	8	1084	c.970G>A	c.(970-972)GTG>ATG	p.V324M	TMPRSS6_uc003aqt.1_Missense_Mutation_p.V315M|TMPRSS6_uc003aqu.2_Missense_Mutation_p.V315M	NM_153609	NP_705837	Q8IU80	TMPS6_HUMAN	transmembrane protease, serine 6	324	CUB 1.|Extracellular (Potential).				angiogenesis|extracellular matrix organization|fibrinolysis|intracellular signal transduction|proteolysis	integral to membrane|intracellular|plasma membrane	serine-type endopeptidase activity			breast(4)|ovary(1)|skin(1)	6																		---	---	---	---
CACNA1I	8911	broad.mit.edu	37	22	40055734	40055734	+	Silent	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:40055734C>T	uc003ayc.2	+	14	2481	c.2481C>T	c.(2479-2481)CTC>CTT	p.L827L	CACNA1I_uc003ayd.2_Silent_p.L792L|CACNA1I_uc003aye.2_Silent_p.L742L|CACNA1I_uc003ayf.2_Silent_p.L707L	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	827	Extracellular (Potential).|II.				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)													---	---	---	---
MPPED1	758	broad.mit.edu	37	22	43831011	43831011	+	Silent	SNP	C	T	T			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:43831011C>T	uc011apv.1	+	3	505	c.282C>T	c.(280-282)TGC>TGT	p.C94C	MPPED1_uc011apw.1_5'UTR|MPPED1_uc011apx.1_Intron|MPPED1_uc011apy.1_Silent_p.C94C|MPPED1_uc011apz.1_Silent_p.C127C	NM_001044370	NP_001037835	O15442	MPPD1_HUMAN	metallophosphoesterase domain containing 1	94							hydrolase activity				0		all_neural(38;0.0244)|Ovarian(80;0.0694)																---	---	---	---
ZNF674	641339	broad.mit.edu	37	X	46359574	46359574	+	Silent	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:46359574G>A	uc004dgr.2	-	6	1677	c.1450C>T	c.(1450-1452)CTG>TTG	p.L484L	ZNF674_uc011mlg.1_Silent_p.L478L	NM_001039891	NP_001034980	Q2M3X9	ZN674_HUMAN	zinc finger family member 674 isoform 1	484	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	X	51150192	51150192	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:51150192A>C	uc004dpj.2	+	1	426	c.324A>C	c.(322-324)GAA>GAC	p.E108D		NM_203407	NP_981952			hypothetical protein LOC340602																														---	---	---	---
FAM123B	139285	broad.mit.edu	37	X	63410103	63410103	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:63410103G>A	uc004dvo.2	-	2	3337	c.3064C>T	c.(3064-3066)CGT>TGT	p.R1022C		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	1022	Pro-rich.				Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112																		---	---	---	---
FAM46D	169966	broad.mit.edu	37	X	79698310	79698310	+	Missense_Mutation	SNP	T	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:79698310T>A	uc004edl.1	+	5	606	c.272T>A	c.(271-273)CTT>CAT	p.L91H	FAM46D_uc004edm.1_Missense_Mutation_p.L91H	NM_152630	NP_689843	Q8NEK8	FA46D_HUMAN	hypothetical protein LOC169966	91										lung(2)	2																		---	---	---	---
RPS6KA6	27330	broad.mit.edu	37	X	83351226	83351226	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:83351226C>A	uc004eej.1	-	20	2024	c.1947G>T	c.(1945-1947)TGG>TGT	p.W649C	RPS6KA6_uc011mqt.1_Missense_Mutation_p.W649C|RPS6KA6_uc011mqu.1_Missense_Mutation_p.W546C	NM_014496	NP_055311	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase polypeptide 6	649	Protein kinase 2.				axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|central_nervous_system(1)|skin(1)	8																		---	---	---	---
PCDH11X	27328	broad.mit.edu	37	X	91131988	91131988	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:91131988A>C	uc004efk.1	+	2	1594	c.749A>C	c.(748-750)AAG>ACG	p.K250T	PCDH11X_uc004efl.1_Missense_Mutation_p.K250T|PCDH11X_uc004efo.1_Missense_Mutation_p.K250T|PCDH11X_uc010nmv.1_Missense_Mutation_p.K250T|PCDH11X_uc004efm.1_Missense_Mutation_p.K250T|PCDH11X_uc004efn.1_Missense_Mutation_p.K250T|PCDH11X_uc004efh.1_Missense_Mutation_p.K250T|PCDH11X_uc004efj.1_Missense_Mutation_p.K250T	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	250	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2																		---	---	---	---
COL4A6	1288	broad.mit.edu	37	X	107430498	107430498	+	Silent	SNP	T	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:107430498T>C	uc004enw.3	-	23	1885	c.1782A>G	c.(1780-1782)GGA>GGG	p.G594G	COL4A6_uc004env.3_Silent_p.G593G|COL4A6_uc011msn.1_Silent_p.G593G|COL4A6_uc010npk.2_Silent_p.G593G	NM_001847	NP_001838	Q14031	CO4A6_HUMAN	type IV alpha 6 collagen isoform A precursor	594	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(6)|urinary_tract(1)|large_intestine(1)	8														Alport_syndrome_with_Diffuse_Leiomyomatosis				---	---	---	---
IRS4	8471	broad.mit.edu	37	X	107975834	107975834	+	Silent	SNP	A	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:107975834A>G	uc004eoc.2	-	1	3774	c.3741T>C	c.(3739-3741)GAT>GAC	p.D1247D		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	1247						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10																		---	---	---	---
ODZ1	10178	broad.mit.edu	37	X	123615810	123615810	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:123615810T>G	uc004euj.2	-	21	3764	c.3700A>C	c.(3700-3702)AGT>CGT	p.S1234R	ODZ1_uc011muj.1_Missense_Mutation_p.S1240R|ODZ1_uc010nqy.2_Missense_Mutation_p.S1241R	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1234	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23																		---	---	---	---
MAGEA10	4109	broad.mit.edu	37	X	151303021	151303021	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:151303021T>C	uc004ffk.2	-	5	1480	c.1072A>G	c.(1072-1074)AGT>GGT	p.S358G	MAGEA10_uc004ffl.2_Missense_Mutation_p.S358G	NM_001011543	NP_001011543	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	358											0	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
LAGE3	8270	broad.mit.edu	37	X	153706704	153706704	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6453-01A-11D-1800-08	TCGA-BR-6453-11A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153706704G>A	uc004fln.1	-	2	577	c.235C>T	c.(235-237)CAT>TAT	p.H79Y		NM_006014	NP_006005	Q14657	LAGE3_HUMAN	L antigen family, member 3	79							protein binding				0	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)																	---	---	---	---
