Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	i_TCGAscape_Amplification_Peaks	i_TCGAscape_Deletion_Peaks	DrugBank	i_ACHILLES_Top_Genes	i_CCLE_ONCOMAP_overlapping_mutations	i_CCLE_ONCOMAP_total_mutations_in_gene	i_CCLE_SEQ_overlapping_mutations	i_CCLE_SEQ_total_mutations_in_gene	MUTSIG_Significant_Genes	OREGANNO_ID	OREGANNO_Values	i_tumor_f	i_init_t_lod	i_t_lod_fstar	i_t_alt_count	i_t_ref_count	i_normal_best_gt	i_failure_reasons	i_judgement	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	dataset	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	type	classification	start	end	gene	chr	ref_allele	tum_allele1	tum_allele2	context_orig	context65	gene_name	newbase	categ	categ_ignoring_null_categ
CRTAC1	55118	broad.mit.edu	36	10	99685992	99685992	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0129-01	TCGA-06-0129-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr10:99685992C>T	uc001kou.1	-	c.346G>A	c.(346-348)GGG>AGG	p.G116R	CRTAC1_uc001kov.2_Missense_Mutation_p.G105R|CRTAC1_uc001kot.1_5'UTR	NM_018058	NP_060528	Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1	116	FG-GAP 2; atypical.					proteinaceous extracellular matrix	calcium ion binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.24)												0.215686	24.457447	28.219165	11	40	CC		KEEP	---	---	---	---	capture		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)	Missense_Mutation	SNP	99685992	99685992	4035	10	C	T	T	23	23	CRTAC1	T	1	1
EXPH5	23086	broad.mit.edu	36	11	107887510	107887510	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0129-01	TCGA-06-0129-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr11:107887510C>T	uc001pkk.1	-	c.3934G>A	c.(3934-3936)GAA>AAA	p.E1312K		NM_015065	NP_055880	Q149M6	Q149M6_HUMAN	exophilin 5 isoform a	1312					intracellular protein transport		Rab GTPase binding			ovary(2)	2		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)												0.269231	109.37775	116.876684	42	114	CC		KEEP	---	---	---	---	capture		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)	Missense_Mutation	SNP	107887510	107887510	5516	11	C	T	T	29	29	EXPH5	T	2	2
LRRC56	115399	broad.mit.edu	36	11	534759	534759	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0129-01	TCGA-06-0129-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr11:534759G>A	uc001lpw.1	+	c.305G>A	c.(304-306)GGC>GAC	p.G102D		NM_198075	NP_932341	Q8IYG6	LRC56_HUMAN	leucine rich repeat containing 56	102	LRR 1.										0		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)												0.611111	35.027974	35.22241	11	7	GG		KEEP	---	---	---	---	capture		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Missense_Mutation	SNP	534759	534759	9387	11	G	A	A	42	42	LRRC56	A	2	2
SLC22A25	387601	broad.mit.edu	36	11	62752535	62752535	+	Silent	SNP	G	A	A			TCGA-06-0129-01	TCGA-06-0129-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr11:62752535G>A	uc001nwr.1	-	c.480C>T	c.(478-480)GGC>GGT	p.G160G	SLC22A25_uc009yoq.1_Non-coding_Transcript|SLC22A25_uc001nws.1_Intron|SLC22A25_uc001nwt.1_Silent_p.G160G	NM_199352	NP_955384	Q6T423	S22AP_HUMAN	putative UST1-like organic anion transporter	160	Helical; Name=2; (Potential).				transmembrane transport	integral to membrane				ovary(3)	3														0.464789	97.475768	97.551369	33	38	GG		KEEP	---	---	---	---	capture			Silent	SNP	62752535	62752535	14951	11	G	A	A	46	46	SLC22A25	A	2	2
DCHS1	8642	broad.mit.edu	36	11	6607847	6607847	+	Missense_Mutation	SNP	G	C	C			TCGA-06-0129-01	TCGA-06-0129-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr11:6607847G>C	uc001mem.1	-	c.4754C>G	c.(4753-4755)GCA>GGA	p.A1585G		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	1585	Cadherin 15.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)												0.333333	8.30561	8.596058	4	8	GG		KEEP	---	---	---	---	capture		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)	Missense_Mutation	SNP	6607847	6607847	4458	11	G	C	C	46	46	DCHS1	C	3	3
HIP1R	9026	broad.mit.edu	36	12	121912005	121912005	+	Silent	SNP	G	A	A			TCGA-06-0129-01	TCGA-06-0129-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr12:121912005G>A	uc001udj.1	+	c.3150G>A	c.(3148-3150)CAG>CAA	p.Q1050Q	HIP1R_uc001udk.1_Silent_p.Q315Q	NM_003959	NP_003950	O75146	HIP1R_HUMAN	huntingtin interacting protein-1-related	1050					receptor-mediated endocytosis	clathrin coated vesicle membrane|coated pit|perinuclear region of cytoplasm	actin binding|phosphatidylinositol binding			ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)													0.106061	6.995902	17.151736	7	59	GG		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(86;4.6e-05)|Epithelial(86;0.000119)|BRCA - Breast invasive adenocarcinoma(302;0.2)	Silent	SNP	121912005	121912005	7400	12	G	A	A	35	35	HIP1R	A	2	2
C12orf11	55726	broad.mit.edu	36	12	26950600	26950600	+	Silent	SNP	G	T	T			TCGA-06-0129-01	TCGA-06-0129-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr12:26950600G>T	uc001rhk.2	-	c.1983C>A	c.(1981-1983)ATC>ATA	p.I661I	C12orf11_uc001rhj.2_Silent_p.I229I	NM_018164	NP_060634	Q9NVM9	M89BB_HUMAN	hypothetical protein LOC55726	661					cell division|mitosis|regulation of mitotic cell cycle		protein binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	Colorectal(261;0.0847)													0.117391	30.256748	63.367241	27	203	GG		KEEP	---	---	---	---	capture			Silent	SNP	26950600	26950600	1719	12	G	T	T	45	45	C12orf11	T	3	3
LRRK2	120892	broad.mit.edu	36	12	38954698	38954698	+	Missense_Mutation	SNP	C	G	G			TCGA-06-0129-01	TCGA-06-0129-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr12:38954698C>G	uc001rmg.2	+	c.1703C>G	c.(1702-1704)TCT>TGT	p.S568C	LRRK2_uc001rmh.1_Missense_Mutation_p.S190C	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	568					activation of MAPKK activity|determination of adult lifespan|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(11)|lung(2)|upper_aerodigestive_tract(1)|large_intestine(1)|stomach(1)|urinary_tract(1)|pancreas(1)	18	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)								1771				0.226351	186.206868	206.530425	67	229	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	38954698	38954698	9409	12	C	G	G	32	32	LRRK2	G	3	3
ANKRD52	283373	broad.mit.edu	36	12	54925197	54925197	+	Missense_Mutation	SNP	A	G	G			TCGA-06-0129-01	TCGA-06-0129-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr12:54925197A>G	uc001skm.2	-	c.2449T>C	c.(2449-2451)TCG>CCG	p.S817P		NM_173595	NP_775866	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	817	ANK 23.						protein binding			ovary(2)	2														0.412791	239.194815	240.336912	71	101	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	54925197	54925197	686	12	A	G	G	9	9	ANKRD52	G	4	4
ANKRD52	283373	broad.mit.edu	36	12	54925639	54925639	+	Silent	SNP	A	C	C			TCGA-06-0129-01	TCGA-06-0129-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr12:54925639A>C	uc001skm.2	-	c.2193T>G	c.(2191-2193)ACT>ACG	p.T731T		NM_173595	NP_775866	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	731	ANK 21.						protein binding			ovary(2)	2														0.531646	127.042494	127.110971	42	37	AA		KEEP	---	---	---	---	capture			Silent	SNP	54925639	54925639	686	12	A	C	C	7	7	ANKRD52	C	4	4
IL22	50616	broad.mit.edu	36	12	66933313	66933313	+	Missense_Mutation	SNP	C	G	G			TCGA-06-0129-01	TCGA-06-0129-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr12:66933313C>G	uc001sty.1	-	c.183G>C	c.(181-183)AAG>AAC	p.K61N		NM_020525	NP_065386	Q9GZX6	IL22_HUMAN	interleukin 22	61					acute-phase response|cell-cell signaling	extracellular space	cytokine activity|interleukin-22 receptor binding				0		Myeloproliferative disorder(1001;0.0255)												0.346154	122.617598	125.342385	45	85	CC		KEEP	---	---	---	---	capture	Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;5.06e-05)|BRCA - Breast invasive adenocarcinoma(357;0.00104)	Missense_Mutation	SNP	66933313	66933313	7973	12	C	G	G	24	24	IL22	G	3	3
NALCN	259232	broad.mit.edu	36	13	100845698	100845698	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0129-01	TCGA-06-0129-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr13:100845698C>T	uc001vox.1	-	c.128G>A	c.(127-129)CGC>CAC	p.R43H	NALCN_uc001voy.2_5'UTR|NALCN_uc001voz.1_Missense_Mutation_p.R43H|NALCN_uc001vpa.1_Missense_Mutation_p.R43H	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	43	Helical; Name=S1 of repeat I; (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)													0.129032	16.738945	29.200114	12	81	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	100845698	100845698	10544	13	C	T	T	27	27	NALCN	T	1	1
FAM86A	196483	broad.mit.edu	36	16	5080313	5080313	+	Missense_Mutation	SNP	C	G	G			TCGA-06-0129-01	TCGA-06-0129-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr16:5080313C>G	uc002cyo.1	-	c.515G>C	c.(514-516)GGC>GCC	p.G172A	FAM86A_uc002cyp.1_Missense_Mutation_p.G138A	NM_201400	NP_958802	Q96G04	FA86A_HUMAN	hypothetical protein LOC196483 isoform 1	172											0														0.09589	7.076044	19.025638	7	66	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	5080313	5080313	5869	16	C	G	G	26	26	FAM86A	G	3	3
SLC43A2	124935	broad.mit.edu	36	17	1436025	1436025	+	Nonsense_Mutation	SNP	G	T	T			TCGA-06-0129-01	TCGA-06-0129-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr17:1436025G>T	uc002fsu.1	-	c.1161C>A	c.(1159-1161)TAC>TAA	p.Y387*	SLC43A2_uc002fsv.1_Nonsense_Mutation_p.Y383*|SLC43A2_uc002fsw.2_Nonsense_Mutation_p.Y383*|SLC43A2_uc002fsx.2_Nonsense_Mutation_p.Y383*	NM_152346	NP_689559	Q8N370	LAT4_HUMAN	solute carrier family 43, member 2	383	Helical; (Potential).				cellular nitrogen compound metabolic process|ion transport	integral to membrane|plasma membrane					0														0.185185	7.158747	9.679375	5	22	GG		KEEP	---	---	---	---	capture		UCEC - Uterine corpus endometrioid carcinoma (25;0.0883)	Nonsense_Mutation	SNP	1436025	1436025	15130	17	G	T	T	48	48	SLC43A2	T	5	3
CALR3	125972	broad.mit.edu	36	19	16454572	16454572	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0129-01	TCGA-06-0129-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr19:16454572C>T	uc002ned.2	-	c.703G>A	c.(703-705)GCC>ACC	p.A235T	MED26_uc002nee.2_Non-coding_Transcript	NM_145046	NP_659483	Q96L12	CALR3_HUMAN	calreticulin 3	235	4 X approximate repeats.|P-domain.|1-4.				protein folding	endoplasmic reticulum lumen	calcium ion binding|sugar binding|unfolded protein binding				0														0.491228	84.591457	84.595124	28	29	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	16454572	16454572	2710	19	C	T	T	27	27	CALR3	T	1	1
ZNF790	388536	broad.mit.edu	36	19	42002710	42002710	+	Nonsense_Mutation	SNP	G	A	A			TCGA-06-0129-01	TCGA-06-0129-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr19:42002710G>A	uc002oew.1	-	c.376C>T	c.(376-378)CAG>TAG	p.Q126*		NM_206894	NP_996777	Q6PG37	ZN790_HUMAN	zinc finger protein 790	126					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.183)													0.420074	335.119093	336.621212	113	156	GG		KEEP	---	---	---	---	capture	COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)		Nonsense_Mutation	SNP	42002710	42002710	18760	19	G	A	A	45	45	ZNF790	A	5	2
SIGLEC6	946	broad.mit.edu	36	19	56725506	56725506	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0129-01	TCGA-06-0129-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr19:56725506C>T	uc002pwy.2	-	c.751G>A	c.(751-753)GCA>ACA	p.A251T	SIGLEC6_uc002pwz.2_Intron|SIGLEC6_uc002pxa.2_Missense_Mutation_p.A251T|SIGLEC6_uc010eoz.1_Missense_Mutation_p.A229T|SIGLEC6_uc010epa.1_Missense_Mutation_p.A240T|SIGLEC6_uc010epb.1_Missense_Mutation_p.A204T	NM_001245	NP_001236	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6 isoform 1	251	Ig-like C2-type 2.|Extracellular (Potential).				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				ovary(1)	1		all_neural(266;0.0199)												0.210526	18.479757	21.425012	8	30	CC		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)	Missense_Mutation	SNP	56725506	56725506	14807	19	C	T	T	27	27	SIGLEC6	T	1	1
AADACL4	343066	broad.mit.edu	36	1	12648900	12648900	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0129-01	TCGA-06-0129-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:12648900G>A	uc001auf.1	+	c.791G>A	c.(790-792)CGT>CAT	p.R264H		NM_001013630	NP_001013652	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	264	Lumenal (Potential).					integral to membrane	carboxylesterase activity				0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)												0.460177	318.980901	319.292386	104	122	GG		KEEP	---	---	---	---	capture		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)	Missense_Mutation	SNP	12648900	12648900	14	1	G	A	A	40	40	AADACL4	A	1	1
MDM4	4194	broad.mit.edu	36	1	202774027	202774027	+	Missense_Mutation	SNP	C	G	G			TCGA-06-0129-01	TCGA-06-0129-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:202774027C>G	uc001hba.1	+	c.479C>G	c.(478-480)ACC>AGC	p.T160S	MDM4_uc001hay.1_Missense_Mutation_p.T160S|MDM4_uc001haz.1_Non-coding_Transcript|MDM4_uc001hbb.1_Missense_Mutation_p.T33S|MDM4_uc001hbc.2_Non-coding_Transcript|MDM4_uc001hbd.1_Non-coding_Transcript|MDM4_uc009xbe.1_Non-coding_Transcript	NM_002393	NP_002384	O15151	MDM4_HUMAN	mouse double minute 4 homolog	160					apoptosis|cell proliferation|cellular response to hypoxia|G0 to G1 transition|negative regulation of apoptosis|negative regulation of cell cycle arrest|negative regulation of cell proliferation|negative regulation of protein catabolic process|negative regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization	nucleus	enzyme binding|zinc ion binding	p.T160S(1)		upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(21;0.00146)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.112)|all_epithelial(62;0.118)|Prostate(682;0.227)									191				0.389474	254.414614	256.445851	74	116	CC		KEEP	---	---	---	---	capture	GBM - Glioblastoma multiforme(2;3.15e-47)|all cancers(3;3.56e-32)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|Epithelial(59;0.143)|BRCA - Breast invasive adenocarcinoma(75;0.143)		Missense_Mutation	SNP	202774027	202774027	9803	1	C	G	G	18	18	MDM4	G	3	3
CR1L	1379	broad.mit.edu	36	1	205934670	205934670	+	Missense_Mutation	SNP	G	T	T			TCGA-06-0129-01	TCGA-06-0129-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:205934670G>T	uc001hga.2	+	c.813G>T	c.(811-813)AAG>AAT	p.K271N	CR1L_uc001hfz.2_Non-coding_Transcript|CR1L_uc001hgb.1_Non-coding_Transcript	NM_175710	NP_783641	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	271	Sushi 4.					cytoplasm|extracellular region|membrane					0														0.142857	55.841033	83.381493	32	192	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	205934670	205934670	3980	1	G	T	T	36	36	CR1L	T	3	3
USH2A	7399	broad.mit.edu	36	1	214118841	214118841	+	Missense_Mutation	SNP	T	G	G			TCGA-06-0129-01	TCGA-06-0129-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr1:214118841T>G	uc001hku.1	-	c.8446A>C	c.(8446-8448)ACT>CCT	p.T2816P		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2816	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|kidney(1)|central_nervous_system(1)	22														0.448718	222.656708	223.008924	70	86	TT		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)	Missense_Mutation	SNP	214118841	214118841	17598	1	T	G	G	59	59	USH2A	G	4	4
DEFB125	245938	broad.mit.edu	36	20	25035	25035	+	Nonsense_Mutation	SNP	C	T	T			TCGA-06-0129-01	TCGA-06-0129-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr20:25035C>T	uc002wcw.1	+	c.448C>T	c.(448-450)CAG>TAG	p.Q150*		NM_153325	NP_697020	Q8N687	DB125_HUMAN	defensin, beta 125 preproprotein	150					defense response to bacterium	extracellular region				ovary(1)|central_nervous_system(1)	2		all_cancers(10;7.65e-05)|Lung NSC(37;0.0417)|all_epithelial(17;0.0676)|all_lung(30;0.0713)|Breast(17;0.231)												0.469388	539.44086	539.76271	184	208	CC		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(29;0.156)		Nonsense_Mutation	SNP	25035	25035	4588	20	C	T	T	29	29	DEFB125	T	5	2
DIP2A	23181	broad.mit.edu	36	21	46802670	46802670	+	Missense_Mutation	SNP	G	C	C	rs35987285	unknown	TCGA-06-0129-01	TCGA-06-0129-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr21:46802670G>C	uc002zjo.1	+	c.3905G>C	c.(3904-3906)GGC>GCC	p.G1302A	DIP2A_uc002zjr.2_Missense_Mutation_p.G269A|DIP2A_uc002zjs.1_5'Flank	NM_015151	NP_055966	Q14689	DIP2A_HUMAN	DIP2-like protein isoform a	1302					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			ovary(2)	2	Breast(49;0.0933)													0.454545	10.860711	10.881393	5	6	GG		KEEP	---	---	---	---	capture		Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)	Missense_Mutation	SNP	46802670	46802670	4706	21	G	C	C	42	42	DIP2A	C	3	3
HMOX1	3162	broad.mit.edu	36	22	34113113	34113113	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0129-01	TCGA-06-0129-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr22:34113113G>A	uc003ant.1	+	c.580G>A	c.(580-582)GCA>ACA	p.A194T		NM_002133	NP_002124	P09601	HMOX1_HUMAN	heme oxygenase (decyclizing) 1	194					angiogenesis|anti-apoptosis|cell death|cellular iron ion homeostasis|endothelial cell proliferation|erythrocyte homeostasis|excretion|heme catabolic process|heme oxidation|intracellular protein kinase cascade|low-density lipoprotein particle clearance|negative regulation of leukocyte migration|negative regulation of smooth muscle cell proliferation|positive regulation of chemokine biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of smooth muscle cell proliferation|positive regulation of vasodilation|protein homooligomerization|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hydrogen peroxide|response to nicotine|smooth muscle hyperplasia|transmembrane transport|wound healing involved in inflammatory response	endoplasmic reticulum membrane|extracellular space|microsome	enzyme binding|heme binding|heme oxygenase (decyclizing) activity|protein homodimerization activity|signal transducer activity			ovary(1)	1					NADH(DB00157)									0.472441	181.496889	181.579984	60	67	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	34113113	34113113	7535	22	G	A	A	38	38	HMOX1	A	1	1
IDH1	3417	broad.mit.edu	36	2	208821357	208821357	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0129-01	TCGA-06-0129-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr2:208821357C>T	uc002vcs.1	-	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.1_Missense_Mutation_p.R132H|IDH1_uc002vcu.1_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(1725)|p.R132?(210)|p.R132C(92)|p.R132L(48)|p.R132G(26)|p.R132S(11)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(1848)|haematopoietic_and_lymphoid_tissue(593)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2451						Pancreas(158;264 1958 3300 35450 36047)				134				0.314815	91.808259	95.104934	34	74	CC		KEEP	---	---	---	---	capture		Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)	Missense_Mutation	SNP	208821357	208821357	7794	2	C	T	T	19	19	IDH1	T	1	1
C3orf22	152065	broad.mit.edu	36	3	127751505	127751505	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0129-01	TCGA-06-0129-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr3:127751505G>A	uc003ejb.1	-	c.322C>T	c.(322-324)CGC>TGC	p.R108C		NM_152533	NP_689746	Q8N5N4	CC022_HUMAN	hypothetical protein LOC152065	108											0														0.177419	22.69199	28.764877	11	51	GG		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(114;0.147)	Missense_Mutation	SNP	127751505	127751505	2308	3	G	A	A	37	37	C3orf22	A	1	1
CHST2	9435	broad.mit.edu	36	3	144323798	144323798	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0129-01	TCGA-06-0129-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr3:144323798C>T	uc003evm.1	+	c.1450C>T	c.(1450-1452)CGG>TGG	p.R484W	CHST2_uc010huw.1_Missense_Mutation_p.R484W	NM_004267	NP_004258	Q9Y4C5	CHST2_HUMAN	carbohydrate (N-acetylglucosamine-6-O)	484	Lumenal (Potential).				inflammatory response|multicellular organismal development|N-acetylglucosamine metabolic process|sulfur compound metabolic process	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			ovary(3)	3														0.148936	22.096363	33.206889	14	80	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	144323798	144323798	3538	3	C	T	T	27	27	CHST2	T	1	1
GPX1	2876	broad.mit.edu	36	3	49370486	49370486	+	Missense_Mutation	SNP	G	C	C			TCGA-06-0129-01	TCGA-06-0129-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr3:49370486G>C	uc003cws.1	-	c.230C>G	c.(229-231)CCG>CGG	p.P77R	GPX1_uc003cwt.1_Missense_Mutation_p.P77R	NM_000581	NP_000572	P07203	GPX1_HUMAN	glutathione peroxidase 1 isoform 1	77					anti-apoptosis|cell redox homeostasis|glutathione metabolic process|heart contraction|hydrogen peroxide catabolic process|negative regulation of caspase activity|oxidation-reduction process|purine base metabolic process|purine nucleotide catabolic process|regulation of gene expression, epigenetic|regulation of mammary gland epithelial cell proliferation|regulation of proteasomal protein catabolic process|release of cytochrome c from mitochondria|response to selenium ion|UV protection	cytosol|mitochondrion	endopeptidase inhibitor activity|glutathione peroxidase activity|SH3 domain binding			large_intestine(1)	1					Glutathione(DB00143)									0.148148	8.283347	11.490593	4	23	GG		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Missense_Mutation	SNP	49370486	49370486	7015	3	G	C	C	39	39	GPX1	C	3	3
ZNF518B	85460	broad.mit.edu	36	4	10055616	10055616	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0129-01	TCGA-06-0129-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr4:10055616C>T	uc003gmn.1	-	c.1435G>A	c.(1435-1437)GTT>ATT	p.V479I	ZNF518B_uc010idn.1_Missense_Mutation_p.V479I	NM_053042	NP_444270	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	479					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3														0.483871	192.102652	192.130235	60	64	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	10055616	10055616	18557	4	C	T	T	19	19	ZNF518B	T	1	1
FAM193A	8603	broad.mit.edu	36	4	2631427	2631427	+	Silent	SNP	C	T	T			TCGA-06-0129-01	TCGA-06-0129-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr4:2631427C>T	uc010icl.1	+	c.720C>T	c.(718-720)CTC>CTT	p.L240L	FAM193A_uc010ick.1_Silent_p.L240L|FAM193A_uc003gfd.1_Silent_p.L240L|FAM193A_uc010icm.1_Non-coding_Transcript|FAM193A_uc003gfe.1_Silent_p.L94L	NM_003704	NP_003695	P78312	F193A_HUMAN	hypothetical protein LOC8603	240										ovary(3)	3														0.219653	84.576022	97.090819	38	135	CC		KEEP	---	---	---	---	capture			Silent	SNP	2631427	2631427	5735	4	C	T	T	30	30	FAM193A	T	2	2
ZNF721	170960	broad.mit.edu	36	4	427518	427518	+	Missense_Mutation	SNP	C	G	G			TCGA-06-0129-01	TCGA-06-0129-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr4:427518C>G	uc003gaf.2	-	c.834G>C	c.(832-834)GAG>GAC	p.E278D	ABCA11P_uc003gac.2_Intron|ABCA11P_uc003gad.2_Intron|ABCA11P_uc003gae.2_Intron|ABCA11P_uc010ibd.1_Intron|ZNF721_uc003gag.1_Missense_Mutation_p.E246D|ZNF721_uc010ibe.1_Missense_Mutation_p.E234D	NM_133474	NP_597731	D9N162	D9N162_HUMAN	zinc finger protein 721	246						intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1														0.163043	34.265408	44.191429	15	77	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	427518	427518	18719	4	C	G	G	32	32	ZNF721	G	3	3
PHF15	23338	broad.mit.edu	36	5	133930054	133930054	+	Missense_Mutation	SNP	A	C	C			TCGA-06-0129-01	TCGA-06-0129-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr5:133930054A>C	uc003kzk.2	+	c.1367A>C	c.(1366-1368)AAC>ACC	p.N456T	PHF15_uc003kzl.2_Missense_Mutation_p.N440T|PHF15_uc003kzm.2_Missense_Mutation_p.N440T|PHF15_uc003kzn.2_Missense_Mutation_p.N440T|PHF15_uc003kzo.1_Missense_Mutation_p.N440T|PHF15_uc003kzp.2_Missense_Mutation_p.N148T	NM_015288	NP_056103	Q9NQC1	JADE2_HUMAN	PHD finger protein 15	440					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding				0														0.35	12.886395	13.297394	7	13	AA		KEEP	---	---	---	---	capture	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		Missense_Mutation	SNP	133930054	133930054	12249	5	A	C	C	2	2	PHF15	C	4	4
MYOZ3	91977	broad.mit.edu	36	5	150030308	150030308	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0129-01	TCGA-06-0129-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr5:150030308G>A	uc003lss.2	+	c.131G>A	c.(130-132)CGC>CAC	p.R44H	MYOZ3_uc003lsr.2_Missense_Mutation_p.R44H	NM_001122853	NP_001116325	Q8TDC0	MYOZ3_HUMAN	myozenin 3	44						sarcomere	protein binding				0		Medulloblastoma(196;0.134)|all_hematologic(541;0.224)												0.235294	20.283655	22.461719	8	26	GG		KEEP	---	---	---	---	capture	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Missense_Mutation	SNP	150030308	150030308	10492	5	G	A	A	38	38	MYOZ3	A	1	1
FABP7	2173	broad.mit.edu	36	6	123143154	123143154	+	Silent	SNP	G	A	A			TCGA-06-0129-01	TCGA-06-0129-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr6:123143154G>A	uc003pzd.2	+	c.93G>A	c.(91-93)AGG>AGA	p.R31R	FABP7_uc003pze.1_Silent_p.R31R|FABP7_uc003pzf.1_Silent_p.R31R	NM_001446	NP_001437	O15540	FABP7_HUMAN	fatty acid binding protein 7, brain	31					negative regulation of cell proliferation	cytoplasm	lipid binding|transporter activity				0					Alpha-Linolenic Acid(DB00132)|gamma-Homolinolenic acid(DB00154)|Icosapent(DB00159)									0.107692	7.173986	17.097702	7	58	GG		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(226;0.226)	Silent	SNP	123143154	123143154	5559	6	G	A	A	42	42	FABP7	A	2	2
PSMB8	5696	broad.mit.edu	36	6	32917472	32917472	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0129-01	TCGA-06-0129-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr6:32917472C>T	uc003oce.1	-	c.556G>A	c.(556-558)GTG>ATG	p.V186M	TAP2_uc003ocb.1_5'Flank|TAP2_uc003ocd.1_5'Flank|PSMB8_uc003ocf.1_Missense_Mutation_p.V182M	NM_148919	NP_683720	P28062	PSB8_HUMAN	proteasome beta 8 subunit isoform E2 proprotein	186					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|type I interferon-mediated signaling pathway|viral reproduction	cytoplasm|nucleus|proteasome core complex	protein binding|threonine-type endopeptidase activity				0						NSCLC(48;53 1172 10859 13624 22883)								0.236364	92.860552	103.332129	39	126	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	32917472	32917472	13136	6	C	T	T	19	19	PSMB8	T	1	1
DYNC1I1	1780	broad.mit.edu	36	7	95495522	95495522	+	Nonsense_Mutation	SNP	C	T	T			TCGA-06-0129-01	TCGA-06-0129-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr7:95495522C>T	uc003uoc.2	+	c.1120C>T	c.(1120-1122)CGA>TGA	p.R374*	DYNC1I1_uc003uob.1_Nonsense_Mutation_p.R337*|DYNC1I1_uc003uod.2_Nonsense_Mutation_p.R357*|DYNC1I1_uc003uoe.2_Nonsense_Mutation_p.R354*|DYNC1I1_uc010lfl.1_Nonsense_Mutation_p.R363*	NM_004411	NP_004402	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1	374	WD 2.				vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole	microtubule binding|microtubule motor activity			ovary(3)|kidney(1)	4	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)													0.201117	83.003987	97.862982	36	143	CC		KEEP	---	---	---	---	capture	STAD - Stomach adenocarcinoma(171;0.0957)		Nonsense_Mutation	SNP	95495522	95495522	5028	7	C	T	T	31	31	DYNC1I1	T	5	1
C10orf46	143384	broad.mit.edu	36	10	120503911	120503913	+	In_Frame_Del	DEL	GGA	-	-			TCGA-06-0129-01	TCGA-06-0129-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:120503911_120503913delGGA	uc001lds.1	-	c.352_354delTCC	c.(352-354)TCCdel	p.S118del	C10orf46_uc009xze.1_Non-coding_Transcript	NM_153810	NP_722517	Q86Y37	CJ046_HUMAN	chromosome 10 open reading frame 46	118					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex	ubiquitin protein ligase binding				0		Lung NSC(174;0.142)|all_lung(145;0.175)		all cancers(201;0.0131)										0.33			3	6				---	---	---	---	capture_indel			In_Frame_Del	DEL	120503911	120503913	1641	10	GGA	-	-	47	47	C10orf46	-	5	5
CREBZF	58487	broad.mit.edu	36	11	85052890	85052892	+	In_Frame_Del	DEL	CTT	-	-			TCGA-06-0129-01	TCGA-06-0129-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:85052890_85052892delCTT	uc001pas.1	-	c.676_678delAAG	c.(676-678)AAGdel	p.K226del	CREBZF_uc001pat.2_Non-coding_Transcript	NM_001039618	NP_001034707	Q9NS37	ZHANG_HUMAN	HCF-binding transcription factor Zhangfei	226	Basic motif.				negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|response to virus	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|specific transcriptional repressor activity			ovary(1)	1		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)				NSCLC(172;674 2044 9050 18334 41735)						OREG0021274	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0.41			82	119				---	---	---	---	capture_indel			In_Frame_Del	DEL	85052890	85052892	4002	11	CTT	-	-	24	24	CREBZF	-	5	5
MIA2	117153	broad.mit.edu	36	14	38773097	38773099	+	In_Frame_Del	DEL	CTT	-	-			TCGA-06-0129-01	TCGA-06-0129-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:38773097_38773099delCTT	uc001wux.1	+	c.28_30delCTT	c.(28-30)CTTdel	p.L12del	MIA2_uc010amy.1_5'UTR	NM_054024	NP_473365	Q96PC5	MIA2_HUMAN	melanoma inhibitory activity 2	12						extracellular region				ovary(1)|breast(1)	2	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0216)										0.36			34	60				---	---	---	---	capture_indel			In_Frame_Del	DEL	38773097	38773099	9954	14	CTT	-	-	24	24	MIA2	-	5	5
CEP250	11190	broad.mit.edu	36	20	33547849	33547850	+	Frame_Shift_Del	DEL	AG	-	-			TCGA-06-0129-01	TCGA-06-0129-01										Phase_I	Unspecified				Illumina GAIIx	g.chr20:33547849_33547850delAG	uc002xcm.1	+	c.3197_3198delAG	c.(3196-3198)CAGfs	p.Q1066fs	CEP250_uc002xcn.1_Frame_Shift_Del_p.Q1010fs	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2 isoform 1	1066	Gln/Glu-rich.|Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)											0.38			59	95				---	---	---	---	capture_indel			Frame_Shift_Del	DEL	33547849	33547850	3385	20	AG	-	-	7	7	CEP250	-	5	5
MYH9	4627	broad.mit.edu	36	22	35075176	35075178	+	In_Frame_Del	DEL	TGA	-	-			TCGA-06-0129-01	TCGA-06-0129-01										Phase_I	Unspecified				Illumina GAIIx	g.chr22:35075176_35075178delTGA	uc003apg.1	-	c.50_52delTCA	c.(49-54)ATCAAC>AAC	p.I17del	MYH9_uc003api.1_In_Frame_Del_p.I17del	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	17	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	10										1624				0.64			38	21				---	---	---	---	capture_indel			In_Frame_Del	DEL	35075176	35075178	10437	22	TGA	-	-	63	63	MYH9	-	5	5
PIK3R1	5295	broad.mit.edu	36	5	67626882	67626883	+	Frame_Shift_Del	DEL	GA	-	-			TCGA-06-0129-01	TCGA-06-0129-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:67626882_67626883delGA	uc003jva.1	+	c.1719_1720delGA	c.(1717-1722)CTGAGAfs	p.L573fs	PIK3R1_uc003jvb.1_Frame_Shift_Del_p.L573fs|PIK3R1_uc003jvc.1_Frame_Shift_Del_p.L273fs|PIK3R1_uc003jvd.1_Frame_Shift_Del_p.L303fs|PIK3R1_uc003jve.1_Frame_Shift_Del_p.L252fs	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	573_574					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.R574_T576del(2)|p.L570_D578del(1)|p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(5)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	99		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)					370	TCGA GBM(4;<1E-8)			0.43			59	79				---	---	---	---	capture_indel			Frame_Shift_Del	DEL	67626882	67626883	12342	5	GA	-	-	45	45	PIK3R1	-	5	5
