Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	i_TCGAscape_Amplification_Peaks	i_TCGAscape_Deletion_Peaks	DrugBank	i_ACHILLES_Top_Genes	i_CCLE_ONCOMAP_overlapping_mutations	i_CCLE_ONCOMAP_total_mutations_in_gene	i_CCLE_SEQ_overlapping_mutations	i_CCLE_SEQ_total_mutations_in_gene	MUTSIG_Significant_Genes	OREGANNO_ID	OREGANNO_Values	i_tumor_f	i_init_t_lod	i_t_lod_fstar	i_t_alt_count	i_t_ref_count	i_normal_best_gt	i_failure_reasons	i_judgement	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	dataset	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	type	classification	start	end	gene	chr	ref_allele	tum_allele1	tum_allele2	context_orig	context65	gene_name	newbase	categ	categ_ignoring_null_categ
MMP26	56547	broad.mit.edu	36	11	4969873	4969873	+	Silent	SNP	C	T	T			TCGA-06-0188-01	TCGA-06-0188-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr11:4969873C>T	uc001lzv.1	+	c.699C>T	c.(697-699)CAC>CAT	p.H233H		NM_021801	NP_068573	Q9NRE1	MMP26_HUMAN	matrix metalloproteinase 26 preproprotein	233					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Medulloblastoma(188;0.0025)|Breast(177;0.0204)|all_neural(188;0.0227)												0.52381	168.024887	168.076399	55	50	CC		KEEP	---	---	---	---	capture		Epithelial(150;1.33e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0287)|LUSC - Lung squamous cell carcinoma(625;0.191)	Silent	SNP	4969873	4969873	10054	11	C	T	T	19	19	MMP26	T	1	1
MAP4K2	5871	broad.mit.edu	36	11	64325010	64325010	+	Silent	SNP	C	G	G			TCGA-06-0188-01	TCGA-06-0188-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr11:64325010C>G	uc001obh.1	-	c.600G>C	c.(598-600)CTG>CTC	p.L200L	MAP4K2_uc001obi.1_Silent_p.L200L	NM_004579	NP_004570	Q12851	M4K2_HUMAN	mitogen-activated protein kinase kinase kinase	200	Protein kinase.				immune response|JNK cascade|protein phosphorylation|vesicle targeting	basolateral plasma membrane|Golgi membrane|soluble fraction	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(1)|pancreas(1)	2										392				0.235714	69.493625	78.451903	33	107	CC		KEEP	---	---	---	---	capture			Silent	SNP	64325010	64325010	9643	11	C	G	G	21	21	MAP4K2	G	3	3
ACADS	35	broad.mit.edu	36	12	119661061	119661061	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0188-01	TCGA-06-0188-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr12:119661061G>A	uc001tza.2	+	c.989G>A	c.(988-990)CGC>CAC	p.R330H	ACADS_uc001tzb.2_Missense_Mutation_p.R211H	NM_000017	NP_000008	P16219	ACADS_HUMAN	short-chain acyl-CoA dehydrogenase precursor	330						mitochondrial matrix	butyryl-CoA dehydrogenase activity			central_nervous_system(2)	2	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)	Lung NSC(355;0.163)			NADH(DB00157)									0.299145	86.476814	90.69701	35	82	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	119661061	119661061	115	12	G	A	A	38	38	ACADS	A	1	1
PTPRB	5787	broad.mit.edu	36	12	69272333	69272333	+	Missense_Mutation	SNP	T	G	G			TCGA-06-0188-01	TCGA-06-0188-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr12:69272333T>G	uc001swc.2	-	c.1776A>C	c.(1774-1776)AGA>AGC	p.R592S	PTPRB_uc001swb.2_Missense_Mutation_p.R374S|PTPRB_uc001swa.2_Missense_Mutation_p.R592S|PTPRB_uc001swd.2_Missense_Mutation_p.R591S|PTPRB_uc009zrr.1_Missense_Mutation_p.R471S|PTPRB_uc001swe.2_Missense_Mutation_p.R592S	NM_001109754	NP_001103224	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	374	Fibronectin type-III 4.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)													0.392157	204.27129	205.827837	60	93	TT		KEEP	---	---	---	---	capture	GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)		Missense_Mutation	SNP	69272333	69272333	13253	12	T	G	G	62	62	PTPRB	G	4	4
ITGAM	3684	broad.mit.edu	36	16	31192223	31192223	+	Silent	SNP	G	A	A			TCGA-06-0188-01	TCGA-06-0188-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr16:31192223G>A	uc002ebr.1	+	c.741G>A	c.(739-741)AAG>AAA	p.K247K	ITGAM_uc002ebq.1_Silent_p.K247K|ITGAM_uc010cam.1_5'Flank	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M precursor	247	VWFA.|Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1														0.374194	172.102047	174.259572	58	97	GG		KEEP	---	---	---	---	capture			Silent	SNP	31192223	31192223	8191	16	G	A	A	33	33	ITGAM	A	2	2
ITGAM	3684	broad.mit.edu	36	16	31194438	31194438	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0188-01	TCGA-06-0188-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr16:31194438G>A	uc002ebr.1	+	c.926G>A	c.(925-927)CGT>CAT	p.R309H	ITGAM_uc002ebq.1_Missense_Mutation_p.R309H|ITGAM_uc010cam.1_De_novo_Start_OutOfFrame	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M precursor	309	VWFA.|Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1														0.42268	119.358542	119.864448	41	56	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	31194438	31194438	8191	16	G	A	A	40	40	ITGAM	A	1	1
DECR2	26063	broad.mit.edu	36	16	395002	395002	+	Missense_Mutation	SNP	C	G	G			TCGA-06-0188-01	TCGA-06-0188-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr16:395002C>G	uc002chb.1	+	c.126C>G	c.(124-126)TTC>TTG	p.F42L	DECR2_uc002chc.1_5'UTR|DECR2_uc010bqv.1_5'UTR|DECR2_uc002chd.1_5'UTR|DECR2_uc002che.1_5'Flank	NM_020664	NP_065715	Q9NUI1	DECR2_HUMAN	2,4-dienoyl CoA reductase 2, peroxisomal	42	NADP (By similarity).				oxidation-reduction process	peroxisome	2,4-dienoyl-CoA reductase (NADPH) activity|binding				0		Hepatocellular(16;0.00015)												0.349282	234.501117	238.695277	73	136	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	395002	395002	4554	16	C	G	G	30	30	DECR2	G	3	3
VAC14	55697	broad.mit.edu	36	16	69377244	69377244	+	Missense_Mutation	SNP	G	C	C			TCGA-06-0188-01	TCGA-06-0188-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr16:69377244G>C	uc002ezm.1	-	c.285C>G	c.(283-285)ATC>ATG	p.I95M	VAC14_uc010cfw.1_De_novo_Start_InFrame|VAC14_uc002ezn.1_De_novo_Start_OutOfFrame	NM_018052	NP_060522	Q08AM6	VAC14_HUMAN	Vac14 homolog	95	HEAT 2.				interspecies interaction between organisms	endoplasmic reticulum|endosome membrane|microsome	protein binding|receptor activity			pancreas(1)	1		Ovarian(137;0.0699)												0.210526	7.588442	9.062843	4	15	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	69377244	69377244	17676	16	G	C	C	37	37	VAC14	C	3	3
MYH8	4626	broad.mit.edu	36	17	10256431	10256431	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0188-01	TCGA-06-0188-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr17:10256431G>A	uc002gmm.2	-	c.1397C>T	c.(1396-1398)GCT>GTT	p.A466V		NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	466	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(3)|breast(2)	5														0.621514	528.846285	532.094117	156	95	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	10256431	10256431	10436	17	G	A	A	34	34	MYH8	A	2	2
ATP2A3	489	broad.mit.edu	36	17	3797506	3797506	+	Silent	SNP	G	T	T			TCGA-06-0188-01	TCGA-06-0188-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr17:3797506G>T	uc002fwy.1	-	c.1023C>A	c.(1021-1023)ACC>ACA	p.T341T	ATP2A3_uc002fwx.1_Silent_p.T341T|ATP2A3_uc002fwz.1_Silent_p.T341T|ATP2A3_uc002fxa.1_Silent_p.T341T|ATP2A3_uc002fxb.1_Silent_p.T341T|ATP2A3_uc002fxc.1_Silent_p.T341T|ATP2A3_uc002fxd.1_Silent_p.T341T	NM_174953	NP_777613	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous isoform e	341	Cytoplasmic (By similarity).				ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			ovary(3)|breast(1)|central_nervous_system(1)	5						GBM(32;29 774 15719 37967)								0.428571	103.299644	103.669989	36	48	GG		KEEP	---	---	---	---	capture		LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)	Silent	SNP	3797506	3797506	1157	17	G	T	T	43	43	ATP2A3	T	3	3
ACSF2	80221	broad.mit.edu	36	17	45895561	45895561	+	Missense_Mutation	SNP	A	G	G			TCGA-06-0188-01	TCGA-06-0188-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr17:45895561A>G	uc002iqu.2	+	c.838A>G	c.(838-840)ATT>GTT	p.I280V		NM_025149	NP_079425	Q96CM8	ACSF2_HUMAN	acyl-CoA synthetase family member 2	280					fatty acid metabolic process	mitochondrion	ATP binding|ligase activity				0	Breast(11;1.93e-18)													0.361022	348.803861	354.118591	113	200	AA		KEEP	---	---	---	---	capture	BRCA - Breast invasive adenocarcinoma(22;1.55e-09)		Missense_Mutation	SNP	45895561	45895561	176	17	A	G	G	8	8	ACSF2	G	4	4
TP53	7157	broad.mit.edu	36	17	7517651	7517652	+	Splice_Site_DNP	DNP	GC	AT	AT			TCGA-06-0188-01	TCGA-06-0188-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:7517651_7517652GC>AT	uc002gim.2	-	c.920_splice	c.e9-1	p.A307_splice	TP53_uc002gig.1_Intron|TP53_uc002gih.1_Splice_Site_DNP_p.A307_splice|TP53_uc010cne.1_5'UTR|TP53_uc010cnf.1_Splice_Site_DNP_p.A175_splice|TP53_uc010cng.1_Splice_Site_DNP_p.A175_splice|TP53_uc002gii.1_Splice_Site_DNP_p.A175_splice|TP53_uc010cnh.1_Splice_Site_DNP_p.A307_splice|TP53_uc010cni.1_Splice_Site_DNP_p.A307_splice|TP53_uc002gij.2_Splice_Site_DNP_p.A307_splice	NM_001126112	NP_001119584			tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of gene-specific transcription from RNA polymerase II promoter|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of gene-specific transcription from RNA polymerase II promoter|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	chromatin|cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|promoter binding|promoter binding|protease binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin protein ligase binding|zinc ion binding	p.?(10)|p.0?(6)|p.A307fs*34(1)|p.L308fs*31(1)|p.A307V(1)		large_intestine(4614)|breast(2344)|upper_aerodigestive_tract(2150)|lung(1958)|ovary(1559)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1212)|stomach(1127)|urinary_tract(1113)|central_nervous_system(1072)|liver(805)|skin(693)|pancreas(370)|biliary_tract(247)|soft_tissue(209)|prostate(192)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(41)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	21904		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)				Pancreas(47;798 1329 9957 10801)		111		690	TCGA GBM(1;<1E-8)|TSP Lung(2;<1E-8)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0.378378	112.913179	114.357262	42	69	GG		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)	Splice_Site_DNP	DNP	7517651	7517652	16923	17	GC	AT	AT	46	46	TP53	AT	5	2
RAVER1	125950	broad.mit.edu	36	19	10295237	10295237	+	Silent	SNP	C	T	T			TCGA-06-0188-01	TCGA-06-0188-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr19:10295237C>T	uc002moa.1	-	c.813G>A	c.(811-813)GCG>GCA	p.A271A		NM_133452	NP_597709	Q8IY67	RAVR1_HUMAN	RAVER1	254	RRM 3.					cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			ovary(1)	1														0.416667	41.425237	41.641165	15	21	CC		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(20;1.81e-09)|Epithelial(33;3.65e-06)|all cancers(31;8.35e-06)		Silent	SNP	10295237	10295237	13555	19	C	T	T	19	19	RAVER1	T	1	1
ACAP3	116983	broad.mit.edu	36	1	1219362	1219362	+	Silent	SNP	C	T	T			TCGA-06-0188-01	TCGA-06-0188-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:1219362C>T	uc001aeb.1	-	c.2220G>A	c.(2218-2220)CTG>CTA	p.L740L	ACAP3_uc001ady.1_Silent_p.L470L|ACAP3_uc001adz.1_Silent_p.L665L|ACAP3_uc001aea.1_Silent_p.L665L	NM_030649	NP_085152	Q96P50	ACAP3_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH	740	ANK 2.				filopodium assembly|regulation of ARF GTPase activity|signal transduction		ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding				0														0.333333	7.020746	7.242779	3	6	CC		KEEP	---	---	---	---	capture			Silent	SNP	1219362	1219362	121	1	C	T	T	25	25	ACAP3	T	2	2
TCHH	7062	broad.mit.edu	36	1	150348256	150348256	+	Missense_Mutation	SNP	C	T	T	rs2496251	unknown	TCGA-06-0188-01	TCGA-06-0188-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:150348256C>T	uc001ezp.2	-	c.4061G>A	c.(4060-4062)CGC>CAC	p.R1354H	TCHH_uc009wne.1_Missense_Mutation_p.R1354H	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1354	23 X 26 AA approximate tandem repeats.			R -> L (in Ref. 1; AAA65582).	keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)													0.432184	520.035877	521.775906	188	247	CC		KEEP	---	---	---	---	capture	LUSC - Lung squamous cell carcinoma(543;0.206)		Missense_Mutation	SNP	150348256	150348256	16226	1	C	T	T	27	27	TCHH	T	1	1
KLHDC7A	127707	broad.mit.edu	36	1	18682052	18682052	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0188-01	TCGA-06-0188-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:18682052G>A	uc001bax.1	+	c.1990G>A	c.(1990-1992)GGC>AGC	p.G664S	KLHDC7A_uc009vpg.1_Missense_Mutation_p.G446S	NM_152375	NP_689588	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	664	Kelch 5.					integral to membrane				ovary(2)	2		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)												0.210526	24.779777	29.194731	12	45	GG		KEEP	---	---	---	---	capture		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Missense_Mutation	SNP	18682052	18682052	8672	1	G	A	A	43	43	KLHDC7A	A	2	2
RYR2	6262	broad.mit.edu	36	1	235675393	235675393	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0188-01	TCGA-06-0188-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:235675393C>T	uc001hyl.1	+	c.1240C>T	c.(1240-1242)CGC>TGC	p.R414C		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	414	Cytoplasmic (By similarity).		R -> L (in CPVT1).		cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)												0.392857	186.989676	188.68369	66	102	CC		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(106;0.00606)		Missense_Mutation	SNP	235675393	235675393	14249	1	C	T	T	19	19	RYR2	T	1	1
FAM54B	56181	broad.mit.edu	36	1	26028677	26028677	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0188-01	TCGA-06-0188-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:26028677C>T	uc001bkq.2	+	c.542C>T	c.(541-543)ACA>ATA	p.T181I	FAM54B_uc001bkr.2_Intron|FAM54B_uc009vrz.1_Missense_Mutation_p.T166I|FAM54B_uc001bks.2_Missense_Mutation_p.T181I|FAM54B_uc001bkt.2_Missense_Mutation_p.T181I|FAM54B_uc001bku.2_Intron|FAM54B_uc001bkv.2_Missense_Mutation_p.T84I	NM_001099625	NP_062457	Q9H019	FA54B_HUMAN	hypothetical protein LOC56181 isoform a	181										pancreas(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)												0.345029	316.72741	323.989419	118	224	CC		KEEP	---	---	---	---	capture		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;1.96e-25)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.00095)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0649)	Missense_Mutation	SNP	26028677	26028677	5805	1	C	T	T	17	17	FAM54B	T	2	2
MANEAL	149175	broad.mit.edu	36	1	38035007	38035007	+	Missense_Mutation	SNP	C	G	G			TCGA-06-0188-01	TCGA-06-0188-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:38035007C>G	uc001cby.2	+	c.665C>G	c.(664-666)GCC>GGC	p.A222G	MANEAL_uc001cbx.2_Missense_Mutation_p.A222G|MANEAL_uc001cbz.2_Intron	NM_001113482	NP_001106954	Q5VSG8	MANEL_HUMAN	mannosidase, endo-alpha-like isoform 3	222	Lumenal (Potential).					Golgi membrane|integral to membrane	hydrolase activity				0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)												0.307692	6.783874	7.219476	4	9	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	38035007	38035007	9605	1	C	G	G	26	26	MANEAL	G	3	3
SLC45A1	50651	broad.mit.edu	36	1	8313124	8313124	+	Silent	SNP	G	A	A			TCGA-06-0188-01	TCGA-06-0188-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:8313124G>A	uc001apb.1	+	c.984G>A	c.(982-984)TCG>TCA	p.S328S	SLC45A1_uc001apc.1_Silent_p.S26S	NM_001080397	NP_001073866	Q9Y2W3	S45A1_HUMAN	DNB5	328					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|pancreas(1)	3	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)												0.490566	75.253007	75.256861	26	27	GG		KEEP	---	---	---	---	capture		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)	Silent	SNP	8313124	8313124	15137	1	G	A	A	38	38	SLC45A1	A	1	1
UMODL1	89766	broad.mit.edu	36	21	42397086	42397086	+	Nonsense_Mutation	SNP	C	T	T			TCGA-06-0188-01	TCGA-06-0188-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr21:42397086C>T	uc002zag.1	+	c.1339C>T	c.(1339-1341)CGA>TGA	p.R447*	UMODL1_uc002zad.1_Nonsense_Mutation_p.R375*|UMODL1_uc002zae.1_Nonsense_Mutation_p.R375*|UMODL1_uc002zaf.1_Nonsense_Mutation_p.R447*|UMODL1_uc010gow.1_Nonsense_Mutation_p.R239*|UMODL1_uc002zai.1_Non-coding_Transcript|UMODL1_uc010gox.1_Non-coding_Transcript|UMODL1_uc010goy.1_Nonsense_Mutation_p.R98*|UMODL1_uc002zaj.1_Non-coding_Transcript|UMODL1_uc010goz.1_Nonsense_Mutation_p.R192*	NM_173568	NP_775839	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 2 precursor	447	Extracellular (Potential).|SEA 1.		R -> Q.			cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)	2						Pancreas(122;680 807 13940 14411 22888 25505 31742 36028 36332 38435)								0.308642	146.200374	151.480983	50	112	CC		KEEP	---	---	---	---	capture			Nonsense_Mutation	SNP	42397086	42397086	17538	21	C	T	T	23	23	UMODL1	T	5	1
LZTR1	8216	broad.mit.edu	36	22	19681542	19681542	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0188-01	TCGA-06-0188-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr22:19681542C>T	uc002zto.1	+	c.2428C>T	c.(2428-2430)CGG>TGG	p.R810W	LZTR1_uc002ztn.1_Missense_Mutation_p.R769W|LZTR1_uc002ztp.1_3'UTR	NM_006767	NP_006758	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	810					anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			ovary(2)|lung(2)	4	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)							p.R810W(EHEB-Tumor)|p.R810W(HCC2279-Tumor)	1299				0.636364	84.607151	85.326604	28	16	CC		KEEP	---	---	---	---	capture	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)		Missense_Mutation	SNP	19681542	19681542	9514	22	C	T	T	27	27	LZTR1	T	1	1
SLC5A7	60482	broad.mit.edu	36	2	107993202	107993202	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0188-01	TCGA-06-0188-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr2:107993202C>T	uc002tdv.1	+	c.1196C>T	c.(1195-1197)ACG>ATG	p.T399M	SLC5A7_uc010fjj.1_Missense_Mutation_p.T399M|SLC5A7_uc010fjk.1_Non-coding_Transcript	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	399	Cytoplasmic (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)	3					Choline(DB00122)									0.246154	75.039588	82.665087	32	98	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	107993202	107993202	15167	2	C	T	T	19	19	SLC5A7	T	1	1
GLI2	2736	broad.mit.edu	36	2	121463653	121463653	+	Silent	SNP	C	G	G			TCGA-06-0188-01	TCGA-06-0188-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr2:121463653C>G	uc010flp.1	+	c.3693C>G	c.(3691-3693)GGC>GGG	p.G1231G	GLI2_uc002tmq.1_Intron|GLI2_uc002tmr.1_Intron|GLI2_uc002tmt.2_Silent_p.G903G|GLI2_uc002tmu.2_Silent_p.G886G	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	1231					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding transcription factor activity|transcription activator activity|zinc ion binding			ovary(7)|central_nervous_system(1)	8	Renal(3;0.0496)	Prostate(154;0.0623)								376				0.25	6.989021	7.901973	4	12	CC		KEEP	---	---	---	---	capture			Silent	SNP	121463653	121463653	6706	2	C	G	G	25	25	GLI2	G	3	3
LRP2	4036	broad.mit.edu	36	2	169715751	169715751	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0188-01	TCGA-06-0188-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr2:169715751G>A	uc002ues.1	-	c.12493C>T	c.(12493-12495)CGC>TGC	p.R4165C		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	4165	Extracellular (Potential).|LDL-receptor class B 35.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	23					Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)					2055				0.365854	213.2325	216.450969	75	130	GG		KEEP	---	---	---	---	capture		STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Missense_Mutation	SNP	169715751	169715751	9329	2	G	A	A	40	40	LRP2	A	1	1
TTN	7273	broad.mit.edu	36	2	179207009	179207009	+	Silent	SNP	T	C	C			TCGA-06-0188-01	TCGA-06-0188-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr2:179207009T>C	uc002umr.1	-	c.34758A>G	c.(34756-34758)AAA>AAG	p.K11586K	TTN_uc002ums.1_Silent_p.K5281K|TTN_uc010frc.1_Silent_p.K5214K|TTN_uc010frd.1_Silent_p.K5089K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12513										ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153										8722				0.446078	323.477391	323.996738	91	113	TT		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)		Silent	SNP	179207009	179207009	17290	2	T	C	C	56	56	TTN	C	4	4
DNAJC10	54431	broad.mit.edu	36	2	183293103	183293103	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0188-01	TCGA-06-0188-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr2:183293103G>A	uc002uow.1	+	c.329G>A	c.(328-330)GGC>GAC	p.G110D	DNAJC10_uc002uox.1_Non-coding_Transcript|DNAJC10_uc002uoy.1_Non-coding_Transcript|DNAJC10_uc002uoz.1_Missense_Mutation_p.G110D|DNAJC10_uc010fro.1_Non-coding_Transcript	NM_018981	NP_061854	Q8IXB1	DJC10_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 10	110					apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|ER-associated protein catabolic process|glycerol ether metabolic process|negative regulation of protein phosphorylation|protein folding|response to endoplasmic reticulum stress	endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|extracellular region	ATPase activator activity|ATPase binding|chaperone binding|electron carrier activity|heat shock protein binding|misfolded protein binding|protein disulfide oxidoreductase activity|unfolded protein binding			ovary(1)|large_intestine(1)|breast(1)	3						Pancreas(56;860 1183 25669 35822 48585)								0.308219	121.81631	126.605014	45	101	GG		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)		Missense_Mutation	SNP	183293103	183293103	4812	2	G	A	A	42	42	DNAJC10	A	2	2
TNS1	7145	broad.mit.edu	36	2	218420799	218420799	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0188-01	TCGA-06-0188-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr2:218420799G>A	uc002vgt.2	-	c.2311C>T	c.(2311-2313)CAT>TAT	p.H771Y	TNS1_uc010fvk.1_Missense_Mutation_p.H896Y|TNS1_uc002vgr.2_Missense_Mutation_p.H771Y|TNS1_uc002vgs.2_Missense_Mutation_p.H771Y|TNS1_uc010fvi.1_Missense_Mutation_p.H458Y|TNS1_uc010fvj.1_Missense_Mutation_p.H839Y	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	771						cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)												0.4	77.545709	78.197429	30	45	GG		KEEP	---	---	---	---	capture		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)	Missense_Mutation	SNP	218420799	218420799	16884	2	G	A	A	46	46	TNS1	A	2	2
ABCB6	10058	broad.mit.edu	36	2	219789017	219789017	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0188-01	TCGA-06-0188-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr2:219789017C>T	uc002vkc.1	-	c.1100G>A	c.(1099-1101)GGG>GAG	p.G367E	ABCB6_uc010fwe.1_Missense_Mutation_p.G321E	NM_005689	NP_005680	Q9NP58	ABCB6_HUMAN	ATP-binding cassette, sub-family B, member 6	367	ABC transmembrane type-1.				cellular iron ion homeostasis|detoxification of cadmium ion|porphyrin biosynthetic process	ATP-binding cassette (ABC) transporter complex|Golgi apparatus|integral to mitochondrial outer membrane|plasma membrane|vacuolar membrane	ATP binding|cadmium ion transmembrane transporter activity|efflux transmembrane transporter activity|heme binding|heme-transporting ATPase activity			breast(1)|central_nervous_system(1)	2		Renal(207;0.0474)												0.590909	41.077678	41.236307	13	9	CC		KEEP	---	---	---	---	capture		Epithelial(149;1.22e-06)|all cancers(144;0.000201)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)	Missense_Mutation	SNP	219789017	219789017	46	2	C	T	T	22	22	ABCB6	T	2	2
TACR3	6870	broad.mit.edu	36	4	104730479	104730479	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0188-01	TCGA-06-0188-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr4:104730479C>T	uc003hxe.1	-	c.1207G>A	c.(1207-1209)GTG>ATG	p.V403M		NM_001059	NP_001050	P29371	NK3R_HUMAN	tachykinin receptor 3	403	Cytoplasmic (Potential).					integral to plasma membrane	tachykinin receptor activity			ovary(2)|skin(1)	3		Hepatocellular(203;0.217)												0.383754	395.196579	399.423717	137	220	CC		KEEP	---	---	---	---	capture		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)	Missense_Mutation	SNP	104730479	104730479	16028	4	C	T	T	19	19	TACR3	T	1	1
KDR	3791	broad.mit.edu	36	4	55671614	55671614	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0188-01	TCGA-06-0188-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr4:55671614G>A	uc003has.1	-	c.1055C>T	c.(1054-1056)GCG>GTG	p.A352V	KDR_uc003hat.1_Missense_Mutation_p.A352V	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III	352	Ig-like C2-type 4.|Extracellular (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|protein phosphorylation|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity	p.A352V(1)		lung(9)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|ovary(2)|kidney(1)	22	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)				Sorafenib(DB00398)|Sunitinib(DB01268)				p.A352V(SCABER-Tumor)	1022	TSP Lung(20;0.16)			0.282828	146.513841	154.903992	56	142	GG		KEEP	---	---	---	---	capture	Epithelial(7;0.189)		Missense_Mutation	SNP	55671614	55671614	8445	4	G	A	A	38	38	KDR	A	1	1
UGT2B11	10720	broad.mit.edu	36	4	70114585	70114585	+	Missense_Mutation	SNP	A	G	G			TCGA-06-0188-01	TCGA-06-0188-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr4:70114585A>G	uc003heh.1	-	c.445T>C	c.(445-447)TTT>CTT	p.F149L		NM_001073	NP_001064	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family,	149					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)	1														0.447674	276.265943	276.674524	77	95	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	70114585	70114585	17515	4	A	G	G	1	1	UGT2B11	G	4	4
UGT2B28	54490	broad.mit.edu	36	4	70191070	70191070	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0188-01	TCGA-06-0188-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr4:70191070C>T	uc003hej.1	+	c.1262C>T	c.(1261-1263)TCG>TTG	p.S421L	UGT2B28_uc010ihr.1_Intron	NM_053039	NP_444267	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family,	421					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity				0					Flunitrazepam(DB01544)									0.371179	246.013998	249.353527	85	144	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	70191070	70191070	17518	4	C	T	T	31	31	UGT2B28	T	1	1
GAK	2580	broad.mit.edu	36	4	848923	848923	+	Silent	SNP	C	G	G			TCGA-06-0188-01	TCGA-06-0188-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr4:848923C>G	uc003gbm.2	-	c.3153G>C	c.(3151-3153)ACG>ACC	p.T1051T	GAK_uc010ibi.1_Silent_p.T232T|GAK_uc010ibj.1_Non-coding_Transcript|GAK_uc003gbl.2_Silent_p.T904T|GAK_uc003gbn.2_Silent_p.T972T	NM_005255	NP_005246	O14976	GAK_HUMAN	cyclin G associated kinase	1051					cell cycle|protein phosphorylation	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			lung(2)|central_nervous_system(1)	3										679				0.315789	9.530619	10.172909	6	13	CC		KEEP	---	---	---	---	capture		Colorectal(103;0.219)	Silent	SNP	848923	848923	6459	4	C	G	G	27	27	GAK	G	3	3
ADAMTS19	171019	broad.mit.edu	36	5	129065131	129065131	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0188-01	TCGA-06-0188-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr5:129065131C>T	uc003kvb.1	+	c.3088C>T	c.(3088-3090)CGC>TGC	p.R1030C	ADAMTS19_uc010jdh.1_Non-coding_Transcript	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1030	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)	8		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)								425				0.236364	61.496534	68.484555	26	84	CC		KEEP	---	---	---	---	capture	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)	Missense_Mutation	SNP	129065131	129065131	265	5	C	T	T	27	27	ADAMTS19	T	1	1
SLC22A5	6584	broad.mit.edu	36	5	131756109	131756109	+	Silent	SNP	C	T	T			TCGA-06-0188-01	TCGA-06-0188-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr5:131756109C>T	uc003kwx.2	+	c.1425C>T	c.(1423-1425)GCC>GCT	p.A475A	SLC22A5_uc003kww.2_Silent_p.A451A|SLC22A5_uc010jdr.1_Silent_p.A71A	NM_003060	NP_003051	O76082	S22A5_HUMAN	solute carrier family 22 member 5	451	Helical; Name=10; (Potential).				positive regulation of intestinal epithelial structure maintenance|quorum sensing involved in interaction with host|sodium ion transport|sodium-dependent organic cation transport	apical plasma membrane|brush border membrane|integral to membrane	ATP binding|carnitine transporter activity|PDZ domain binding|symporter activity				0		all_cancers(142;0.0751)|Breast(839;0.198)			L-Carnitine(DB00583)									0.123656	28.540355	54.269854	23	163	CC		KEEP	---	---	---	---	capture	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		Silent	SNP	131756109	131756109	14954	5	C	T	T	23	23	SLC22A5	T	1	1
C5orf33	133686	broad.mit.edu	36	5	36233467	36233467	+	Missense_Mutation	SNP	A	T	T			TCGA-06-0188-01	TCGA-06-0188-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr5:36233467A>T	uc003jkf.2	-	c.1123T>A	c.(1123-1125)TTC>ATC	p.F375I	C5orf33_uc003jke.2_Non-coding_Transcript|C5orf33_uc010iux.1_Missense_Mutation_p.F180I|C5orf33_uc003jkg.2_Missense_Mutation_p.F212I	NM_001085411	NP_001078880	Q4G0N4	CE033_HUMAN	hypothetical protein LOC133686 isoform 1	375							NAD+ kinase activity			ovary(2)	2	all_lung(31;5.63e-05)													0.418033	144.099436	144.815738	51	71	AA		KEEP	---	---	---	---	capture	Epithelial(62;0.0254)|all cancers(62;0.0805)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)		Missense_Mutation	SNP	36233467	36233467	2390	5	A	T	T	1	1	C5orf33	T	4	4
SASH1	23328	broad.mit.edu	36	6	148882433	148882433	+	Missense_Mutation	SNP	A	G	G			TCGA-06-0188-01	TCGA-06-0188-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr6:148882433A>G	uc003qme.1	+	c.920A>G	c.(919-921)TAC>TGC	p.Y307C		NM_015278	NP_056093	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	307							protein binding			central_nervous_system(1)	1		Ovarian(120;0.0169)												0.384146	212.6017	214.525557	63	101	AA		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)	Missense_Mutation	SNP	148882433	148882433	14329	6	A	G	G	14	14	SASH1	G	4	4
DAAM2	23500	broad.mit.edu	36	6	39972605	39972605	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0188-01	TCGA-06-0188-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr6:39972605G>A	uc003oow.1	+	c.2381G>A	c.(2380-2382)CGT>CAT	p.R794H	DAAM2_uc003oox.1_Missense_Mutation_p.R794H	NM_015345	NP_056160	Q86T65	DAAM2_HUMAN	dishevelled associated activator of	794	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)|skin(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)													0.435897	48.7806	48.917633	17	22	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	39972605	39972605	4382	6	G	A	A	40	40	DAAM2	A	1	1
PRPH2	5961	broad.mit.edu	36	6	42780084	42780084	+	Silent	SNP	G	A	A			TCGA-06-0188-01	TCGA-06-0188-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr6:42780084G>A	uc003osk.1	-	c.825C>T	c.(823-825)TTC>TTT	p.F275F		NM_000322	NP_000313	P23942	PRPH2_HUMAN	peripherin 2	275	Helical; (Potential).				cell adhesion|response to stimulus|visual perception	integral to membrane				ovary(4)|central_nervous_system(1)	5	Colorectal(47;0.196)													0.181818	8.18661	10.279218	4	18	GG		KEEP	---	---	---	---	capture	Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.00178)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0904)		Silent	SNP	42780084	42780084	13020	6	G	A	A	37	37	PRPH2	A	1	1
TTBK1	84630	broad.mit.edu	36	6	43329359	43329359	+	Missense_Mutation	SNP	A	G	G			TCGA-06-0188-01	TCGA-06-0188-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr6:43329359A>G	uc003ouq.1	+	c.406A>G	c.(406-408)AAG>GAG	p.K136E		NM_032538	NP_115927	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	136	Protein kinase.				protein phosphorylation	cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	9										85				0.285714	11.135354	12.005288	6	15	AA		KEEP	---	---	---	---	capture	Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)		Missense_Mutation	SNP	43329359	43329359	17230	6	A	G	G	5	5	TTBK1	G	4	4
KHDRBS2	202559	broad.mit.edu	36	6	63053738	63053738	+	Silent	SNP	C	T	T			TCGA-06-0188-01	TCGA-06-0188-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr6:63053738C>T	uc003peg.2	-	c.75G>A	c.(73-75)TCG>TCA	p.S25S		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	25					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			ovary(3)|liver(1)|skin(1)	5														0.319149	38.127672	39.483686	15	32	CC		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(397;0.149)	Silent	SNP	63053738	63053738	8453	6	C	T	T	27	27	KHDRBS2	T	1	1
MLL3	58508	broad.mit.edu	36	7	151591106	151591106	+	Silent	SNP	A	G	G			TCGA-06-0188-01	TCGA-06-0188-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr7:151591106A>G	uc003wla.1	-	c.1227T>C	c.(1225-1227)TGT>TGC	p.C409C		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	409	PHD-type 2.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			pancreas(12)|ovary(7)|large_intestine(6)|central_nervous_system(4)|urinary_tract(1)|skin(1)	31	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)				Colon(68;14 1149 1884 27689 34759)				1780				0.15942	88.969871	119.581713	44	232	AA		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)	Silent	SNP	151591106	151591106	10012	7	A	G	G	6	6	MLL3	G	4	4
DPYS	1807	broad.mit.edu	36	8	105525670	105525670	+	Missense_Mutation	SNP	C	A	A			TCGA-06-0188-01	TCGA-06-0188-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr8:105525670C>A	uc003yly.2	-	c.775G>T	c.(775-777)GCG>TCG	p.A259S		NM_001385	NP_001376	Q14117	DPYS_HUMAN	dihydropyrimidinase	259					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			ovary(1)	1														0.234783	67.263216	74.664987	27	88	CC		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)		Missense_Mutation	SNP	105525670	105525670	4930	8	C	A	A	28	28	DPYS	A	3	3
COL14A1	7373	broad.mit.edu	36	8	121329089	121329089	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0188-01	TCGA-06-0188-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr8:121329089C>T	uc003yox.1	+	c.2536C>T	c.(2536-2538)CGC>TGC	p.R846C	COL14A1_uc003yoy.2_Missense_Mutation_p.R524C	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	846	Fibronectin type-III 7.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)									1131				0.462428	228.954181	229.169071	80	93	CC		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)		Missense_Mutation	SNP	121329089	121329089	3809	8	C	T	T	27	27	COL14A1	T	1	1
TG	7038	broad.mit.edu	36	8	133948481	133948481	+	Silent	SNP	G	A	A			TCGA-06-0188-01	TCGA-06-0188-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr8:133948481G>A	uc003ytw.1	+	c.54G>A	c.(52-54)TCG>TCA	p.S18S		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin	18					hormone biosynthetic process|regulation of synaptic transmission|signal transduction		carboxylesterase activity|hormone activity			ovary(8)|breast(4)|pancreas(1)	13	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)								1778				0.461538	38.698256	38.731669	12	14	GG		KEEP	---	---	---	---	capture	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)	Silent	SNP	133948481	133948481	16341	8	G	A	A	39	39	TG	A	1	1
AKNA	80709	broad.mit.edu	36	9	116169719	116169719	+	Silent	SNP	C	T	T			TCGA-06-0188-01	TCGA-06-0188-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr9:116169719C>T	uc004biq.2	-	c.1653G>A	c.(1651-1653)CGG>CGA	p.R551R	AKNA_uc004bio.2_Silent_p.R11R|AKNA_uc004bip.2_Silent_p.R470R|AKNA_uc004bir.2_Silent_p.R551R|AKNA_uc004bis.2_Silent_p.R551R|AKNA_uc010mve.1_Silent_p.R432R|AKNA_uc004biu.1_Silent_p.R292R|AKNA_uc004biv.1_Silent_p.R551R	NM_030767	NP_110394	Q7Z591	AKNA_HUMAN	AT-hook transcription factor	551					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(4)|central_nervous_system(2)	6														0.515337	272.803174	272.836493	84	79	CC		KEEP	---	---	---	---	capture			Silent	SNP	116169719	116169719	466	9	C	T	T	22	22	AKNA	T	2	2
TNC	3371	broad.mit.edu	36	9	116837402	116837402	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0188-01	TCGA-06-0188-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr9:116837402C>T	uc004bjj.2	-	c.5689G>A	c.(5689-5691)GAG>AAG	p.E1897K	TNC_uc010mvf.1_Missense_Mutation_p.E1624K	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	1897	Fibronectin type-III 15.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding	p.E1897K(1)		central_nervous_system(4)|ovary(1)	5														0.335106	164.947078	169.480057	63	125	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	116837402	116837402	16811	9	C	T	T	29	29	TNC	T	2	2
OR5C1	392391	broad.mit.edu	36	9	124591081	124591081	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0188-01	TCGA-06-0188-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr9:124591081G>A	uc004bmw.1	+	c.49G>A	c.(49-51)GTC>ATC	p.V17I		NM_001001923	NP_001001923	Q8NGR4	OR5C1_HUMAN	olfactory receptor, family 5, subfamily C,	17	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1														0.314286	113.345911	117.644608	44	96	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	124591081	124591081	11563	9	G	A	A	40	40	OR5C1	A	1	1
CNTLN	54875	broad.mit.edu	36	9	17125340	17125340	+	Missense_Mutation	SNP	T	A	A			TCGA-06-0188-01	TCGA-06-0188-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr9:17125340T>A	uc003zmz.2	+	c.277T>A	c.(277-279)TCG>ACG	p.S93T	CNTLN_uc003zmx.2_Missense_Mutation_p.S93T|CNTLN_uc003zmy.1_Missense_Mutation_p.S93T|CNTLN_uc003zmw.1_Missense_Mutation_p.S93T	NM_017738	NP_060208	Q9NXG0	CNTLN_HUMAN	centlein isoform 1	93						centriole|membrane	two-component sensor activity			pancreas(1)	1														0.545455	16.348397	16.367958	6	5	TT		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(50;6.14e-10)	Missense_Mutation	SNP	17125340	17125340	3777	9	T	A	A	54	54	CNTLN	A	4	4
PRUNE2	158471	broad.mit.edu	36	9	78658940	78658940	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0188-01	TCGA-06-0188-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr9:78658940C>T	uc010mpk.1	-	c.41G>A	c.(40-42)CGA>CAA	p.R14Q	PRUNE2_uc004akn.1_Missense_Mutation_p.R14Q	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	14					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0														0.292135	69.441548	72.869607	26	63	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	78658940	78658940	13092	9	C	T	T	31	31	PRUNE2	T	1	1
PASD1	139135	broad.mit.edu	36	X	150520684	150520684	+	Missense_Mutation	SNP	G	T	T			TCGA-06-0188-01	TCGA-06-0188-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chrX:150520684G>T	uc004fev.2	+	c.3G>T	c.(1-3)ATG>ATT	p.M1I		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	PAS domain containing 1	1						nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)													0.878378	211.41239	221.783513	65	9	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	150520684	150520684	11888	23	G	T	T	45	45	PASD1	T	3	3
PTEN	5728	broad.mit.edu	36	10	89710792	89710792	+	Frame_Shift_Del	DEL	A	-	-			TCGA-06-0188-01	TCGA-06-0188-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:89710792_89710792delA	uc001kfb.1	+	c.963_963delA	c.(961-963)ACAfs	p.T321fs		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	321	C2 tensin-type.				apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of focal adhesion assembly|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of cyclin-dependent protein kinase activity|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.T321fs*23(9)|p.T321fs*3(7)|p.N323fs*2(2)|p.T319_K332del(1)|p.T321fs*22(1)|p.G165_K342del(1)|p.G165_*404del(1)|p.L316fs*1(1)|p.W274_F341del(1)|p.V317_K322del(1)		endometrium(831)|central_nervous_system(654)|skin(119)|haematopoietic_and_lymphoid_tissue(101)|prostate(97)|large_intestine(90)|breast(67)|lung(63)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(21)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(12)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2308		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)				31	p.T321fs(CAL51-Tumor)|p.T321fs(MFE296-Tumor)|p.T321fs(SKUT1-Tumor)	264	TCGA GBM(2;<1E-8)|TSP Lung(26;0.18)			0.66			127	64				---	---	---	---	capture_indel			Frame_Shift_Del	DEL	89710792	89710792	13192	10	A	-	-	5	5	PTEN	-	5	5
TMPRSS11A	339967	broad.mit.edu	36	4	68467293	68467293	+	Frame_Shift_Del	DEL	G	-	-			TCGA-06-0188-01	TCGA-06-0188-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:68467293_68467293delG	uc003hdr.1	-	c.954_954delC	c.(952-954)TACfs	p.Y318fs	LOC550112_uc003hdl.2_Intron|TMPRSS11A_uc003hds.1_Frame_Shift_Del_p.Y315fs	NM_182606	NP_872412	Q6ZMR5	TM11A_HUMAN	transmembrane protease, serine 11A isoform 1	318	Peptidase S1.|Extracellular (Potential).				cell cycle|proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity				0						NSCLC(26;2 894 10941 14480 22546)								0.42			120	165				---	---	---	---	capture_indel			Frame_Shift_Del	DEL	68467293	68467293	16779	4	G	-	-	36	36	TMPRSS11A	-	5	5
