Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	i_TCGAscape_Amplification_Peaks	i_TCGAscape_Deletion_Peaks	DrugBank	i_ACHILLES_Top_Genes	i_CCLE_ONCOMAP_overlapping_mutations	i_CCLE_ONCOMAP_total_mutations_in_gene	i_CCLE_SEQ_overlapping_mutations	i_CCLE_SEQ_total_mutations_in_gene	MUTSIG_Significant_Genes	OREGANNO_ID	OREGANNO_Values	i_tumor_f	i_init_t_lod	i_t_lod_fstar	i_t_alt_count	i_t_ref_count	i_normal_best_gt	i_failure_reasons	i_judgement	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	dataset	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	type	classification	start	end	gene	chr	ref_allele	tum_allele1	tum_allele2	context_orig	context65	gene_name	newbase	categ	categ_ignoring_null_categ
PAOX	196743	broad.mit.edu	36	10	135053235	135053235	+	Silent	SNP	C	T	T			TCGA-06-0646-01	TCGA-06-0646-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr10:135053235C>T	uc001lmv.1	+	c.1386C>T	c.(1384-1386)GGC>GGT	p.G462G	PAOX_uc001lmw.1_Intron|PAOX_uc001lmx.1_Intron|PAOX_uc001lmy.1_Intron|PAOX_uc001lmz.1_Non-coding_Transcript|PAOX_uc001lna.1_Non-coding_Transcript|PAOX_uc001lnb.1_Non-coding_Transcript|PAOX_uc001lnc.1_Non-coding_Transcript	NM_152911	NP_690875	Q6QHF9	PAOX_HUMAN	polyamine oxidase (exo-N4-amino) isoform 1	600					oxidation-reduction process|polyamine biosynthetic process|xenobiotic metabolic process	peroxisomal matrix	polyamine oxidase activity				0		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)												0.6	50.132125	50.351979	15	10	CC		KEEP	---	---	---	---	capture		all cancers(32;4.39e-07)|OV - Ovarian serous cystadenocarcinoma(35;1.21e-06)|Epithelial(32;1.94e-06)	Silent	SNP	135053235	135053235	11840	10	C	T	T	27	27	PAOX	T	1	1
POU2AF1	5450	broad.mit.edu	36	11	110730336	110730336	+	Missense_Mutation	SNP	A	G	G			TCGA-06-0646-01	TCGA-06-0646-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr11:110730336A>G	uc001plg.2	-	c.631T>C	c.(631-633)TCT>CCT	p.S211P		NM_006235	NP_006226	Q16633	OBF1_HUMAN	POU class 2 associating factor 1	211					humoral immune response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			kidney(1)	1		all_cancers(61;1.36e-12)|all_epithelial(67;1.87e-07)|Melanoma(852;1.46e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|all_neural(223;0.0146)|Medulloblastoma(222;0.0245)|Breast(348;0.0389)								95				0.490909	187.648982	187.656852	54	56	AA		KEEP	---	---	---	---	capture		Epithelial(105;1.01e-06)|BRCA - Breast invasive adenocarcinoma(274;3.12e-06)|all cancers(92;1.8e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0364)	Missense_Mutation	SNP	110730336	110730336	12700	11	A	G	G	11	11	POU2AF1	G	4	4
CHEK1	1111	broad.mit.edu	36	11	125010616	125010616	+	Missense_Mutation	SNP	A	T	T			TCGA-06-0646-01	TCGA-06-0646-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr11:125010616A>T	uc009zbo.1	+	c.696A>T	c.(694-696)AAA>AAT	p.K232N	CHEK1_uc001qcf.2_Missense_Mutation_p.K232N|CHEK1_uc009zbp.1_Missense_Mutation_p.K232N|CHEK1_uc001qcg.2_Missense_Mutation_p.K232N|CHEK1_uc009zbq.1_Missense_Mutation_p.K232N|CHEK1_uc001qch.2_Missense_Mutation_p.K138N|CHEK1_uc001qci.1_Non-coding_Transcript	NM_001114122	NP_001107594	O14757	CHK1_HUMAN	CHK1 checkpoint homolog	232	Protein kinase.				cellular response to mechanical stimulus|DNA repair|DNA replication|gamete generation|negative regulation of cell proliferation|reciprocal meiotic recombination|regulation of cyclin-dependent protein kinase activity|replicative senescence	condensed nuclear chromosome|microtubule organizing center|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(3)|lung(1)	4	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)								124				0.302752	176.761218	184.335895	66	152	AA		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0748)	Missense_Mutation	SNP	125010616	125010616	3468	11	A	T	T	1	1	CHEK1	T	4	4
ETNK1	55500	broad.mit.edu	36	12	22669430	22669430	+	Silent	SNP	C	G	G			TCGA-06-0646-01	TCGA-06-0646-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr12:22669430C>G	uc001rft.1	+	c.66C>G	c.(64-66)CTC>CTG	p.L22L	ETNK1_uc001rfs.1_Silent_p.L22L|ETNK1_uc009ziz.1_Silent_p.L22L	NM_018638	NP_061108	Q9HBU6	EKI1_HUMAN	ethanolamine kinase 1 isoform A	22					phosphatidylethanolamine biosynthetic process	cytoplasm	ATP binding|ethanolamine kinase activity				0						Esophageal Squamous(42;87 913 3224 6226 43339)								0.444444	51.999062	52.095086	16	20	CC		KEEP	---	---	---	---	capture			Silent	SNP	22669430	22669430	5466	12	C	G	G	29	29	ETNK1	G	3	3
TMTC1	83857	broad.mit.edu	36	12	29648402	29648402	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0646-01	TCGA-06-0646-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr12:29648402G>A	uc001rjb.1	-	c.902C>T	c.(901-903)GCG>GTG	p.A301V	TMTC1_uc001riz.1_Missense_Mutation_p.A58V|TMTC1_uc001rja.1_Missense_Mutation_p.A145V|TMTC1_uc001rjc.1_Missense_Mutation_p.A363V	NM_175861	NP_787057	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat	301	Helical; (Potential).					integral to membrane	binding				0	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)													0.426471	85.564108	85.884527	29	39	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	29648402	29648402	16801	12	G	A	A	38	38	TMTC1	A	1	1
IPO4	79711	broad.mit.edu	36	14	23720642	23720642	+	Missense_Mutation	SNP	C	G	G			TCGA-06-0646-01	TCGA-06-0646-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr14:23720642C>G	uc001wmv.1	-	c.2962G>C	c.(2962-2964)GCC>CCC	p.A988P	IPO4_uc001wmu.1_Missense_Mutation_p.A650P|IPO4_uc001wmw.1_Non-coding_Transcript|IPO4_uc001wmx.1_Missense_Mutation_p.A852P|IPO4_uc001wmy.1_Missense_Mutation_p.A852P|IPO4_uc001wmz.1_Missense_Mutation_p.A988P|IPO4_uc001wmt.1_Missense_Mutation_p.A466P	NM_024658	NP_078934	Q8TEX9	IPO4_HUMAN	importin 4	988					intracellular protein transport	cytoplasm|nucleus	protein binding|protein transporter activity			kidney(1)	1														0.363636	7.264944	7.457094	4	7	CC		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(265;0.0087)	Missense_Mutation	SNP	23720642	23720642	8096	14	C	G	G	25	25	IPO4	G	3	3
FAM82A2	55177	broad.mit.edu	36	15	38817214	38817214	+	Silent	SNP	G	C	C			TCGA-06-0646-01	TCGA-06-0646-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr15:38817214G>C	uc001zmo.1	-	c.1128C>G	c.(1126-1128)GTC>GTG	p.V376V	FAM82A2_uc001zmp.1_Silent_p.V376V|FAM82A2_uc001zmq.1_Silent_p.V376V	NM_018145	NP_060615	Q96TC7	RMD3_HUMAN	family with sequence similarity 82, member A2	376					apoptosis|cell differentiation	integral to membrane|microtubule|mitochondrial membrane|nucleus|spindle pole	protein binding				0														0.208333	7.685378	9.562106	5	19	GG		KEEP	---	---	---	---	capture			Silent	SNP	38817214	38817214	5857	15	G	C	C	33	33	FAM82A2	C	3	3
FUS	2521	broad.mit.edu	36	16	31109809	31109809	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0646-01	TCGA-06-0646-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr16:31109809G>A	uc002ebi.1	+	c.1421G>A	c.(1420-1422)CGT>CAT	p.R474H	FUS_uc002ebf.1_Missense_Mutation_p.R473H|FUS_uc002ebh.1_Missense_Mutation_p.R472H|FUS_uc002ebg.1_Missense_Mutation_p.R268H|FUS_uc002ebj.1_Missense_Mutation_p.R269H	NM_004960	NP_004951	P35637	FUS_HUMAN	fusion (involved in t(12;16) in malignant	473	Arg/Gly-rich.				cell death|nuclear mRNA splicing, via spliceosome	nucleoplasm	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		FUS/DDIT3(623)|FUS/ERG(163)|FUS/CREB3L2(158)|FUS/CREB3L1(6)|FUS/ATF1(4)|FUS/FEV(2)	soft_tissue(791)|haematopoietic_and_lymphoid_tissue(153)|bone(12)|breast(2)	958		Renal(780;0.000219)|Breast(268;0.00957)|Hepatocellular(780;0.121)								180				0.506098	255.61709	255.62231	83	81	GG		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(240;2.31e-05)|Kidney(780;0.000209)	Missense_Mutation	SNP	31109809	31109809	6351	16	G	A	A	40	40	FUS	A	1	1
ZNF174	7727	broad.mit.edu	36	16	3398845	3398845	+	Silent	SNP	G	A	A			TCGA-06-0646-01	TCGA-06-0646-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr16:3398845G>A	uc002cvc.1	+	c.1149G>A	c.(1147-1149)CAG>CAA	p.Q383Q		NM_003450	NP_003441	Q15697	ZN174_HUMAN	zinc finger protein 174 isoform a	383	C2H2-type 3.				negative regulation of gene-specific transcription from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|cytoplasm|nucleus	promoter binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|specific transcriptional repressor activity|zinc ion binding				0														0.49505	163.645346	163.647547	50	51	GG		KEEP	---	---	---	---	capture			Silent	SNP	3398845	3398845	18335	16	G	A	A	36	36	ZNF174	A	2	2
PDPR	55066	broad.mit.edu	36	16	68748090	68748090	+	Missense_Mutation	SNP	T	G	G			TCGA-06-0646-01	TCGA-06-0646-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr16:68748090T>G	uc002eyf.1	+	c.2444T>G	c.(2443-2445)TTT>TGT	p.F815C	CLEC18C_uc002exy.1_Intron|PDPR_uc002eyg.1_Missense_Mutation_p.F483C|PDPR_uc002eyh.1_Missense_Mutation_p.F161C	NM_017990	NP_060460	Q8NCN5	PDPR_HUMAN	pyruvate dehydrogenase phosphatase regulatory	816					glycine catabolic process|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	aminomethyltransferase activity|oxidoreductase activity			breast(1)	1														0.175772	171.604728	213.322608	74	347	TT		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(221;0.124)	Missense_Mutation	SNP	68748090	68748090	12110	16	T	G	G	64	64	PDPR	G	4	4
MON1B	22879	broad.mit.edu	36	16	75787054	75787054	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0646-01	TCGA-06-0646-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr16:75787054G>A	uc002fez.1	+	c.1417G>A	c.(1417-1419)GCT>ACT	p.A473T	MON1B_uc002ffa.1_Missense_Mutation_p.A353T	NM_014940	NP_055755	Q7L1V2	MON1B_HUMAN	MON1 homolog B	473							protein binding				0														0.429487	200.493243	201.170951	67	89	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	75787054	75787054	10090	16	G	A	A	42	42	MON1B	A	2	2
LRRC50	123872	broad.mit.edu	36	16	82741428	82741428	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0646-01	TCGA-06-0646-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr16:82741428C>T	uc002fhl.2	+	c.332C>T	c.(331-333)ACG>ATG	p.T111M	LRRC50_uc010chi.1_Non-coding_Transcript	NM_178452	NP_848547	Q8NEP3	LRC50_HUMAN	leucine rich repeat containing 50	111	LRR 1.		Missing (in CILD13).		axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding			ovary(4)|pancreas(1)	5														0.415842	130.53545	131.159146	42	59	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	82741428	82741428	9384	16	C	T	T	19	19	LRRC50	T	1	1
USP6	9098	broad.mit.edu	36	17	4983387	4983387	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0646-01	TCGA-06-0646-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr17:4983387C>T	uc002gau.1	+	c.1192C>T	c.(1192-1194)CGG>TGG	p.R398W	USP6_uc002gav.1_Missense_Mutation_p.R398W|USP6_uc010ckz.1_Missense_Mutation_p.R81W	NM_004505	NP_004496	P35125	UBP6_HUMAN	ubiquitin specific protease 6	398					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)	1										464				0.125	11.609451	22.59249	10	70	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	4983387	4983387	17650	17	C	T	T	27	27	USP6	T	1	1
MKS1	54903	broad.mit.edu	36	17	53643049	53643049	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0646-01	TCGA-06-0646-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr17:53643049C>T	uc002ivr.1	-	c.994G>A	c.(994-996)GTC>ATC	p.V332I	MKS1_uc002ivs.1_Missense_Mutation_p.V332I	NM_017777	NP_060247	Q9NXB0	MKS1_HUMAN	Meckel syndrome, type 1	332	B9.				cilium assembly	centrosome|cilium|microtubule basal body	protein binding			ovary(1)	1														0.694215	282.943897	287.014786	84	37	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	53643049	53643049	9999	17	C	T	T	19	19	MKS1	T	1	1
LLGL2	3993	broad.mit.edu	36	17	71067069	71067069	+	Silent	SNP	G	C	C			TCGA-06-0646-01	TCGA-06-0646-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr17:71067069G>C	uc002joh.1	+	c.513G>C	c.(511-513)TCG>TCC	p.S171S	LLGL2_uc002jog.1_Silent_p.S171S|LLGL2_uc010dgf.1_Silent_p.S171S|LLGL2_uc002joi.1_Silent_p.S171S|LLGL2_uc010dgg.1_Silent_p.S171S|LLGL2_uc002joj.1_Silent_p.S160S	NM_001031803	NP_001026973	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 isoform c	171					cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			ovary(2)	2	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)													0.163793	35.989217	48.415194	19	97	GG		KEEP	---	---	---	---	capture	all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)		Silent	SNP	71067069	71067069	9163	17	G	C	C	39	39	LLGL2	C	3	3
TMC6	11322	broad.mit.edu	36	17	73629323	73629323	+	Missense_Mutation	SNP	G	C	C			TCGA-06-0646-01	TCGA-06-0646-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr17:73629323G>C	uc002juj.1	-	c.1292C>G	c.(1291-1293)GCG>GGG	p.A431G	TMC6_uc002jui.1_Missense_Mutation_p.A70G|TMC6_uc010dhf.1_Missense_Mutation_p.A264G|TMC6_uc002juk.2_Missense_Mutation_p.A431G|TMC6_uc010dhg.1_Intron|TMC6_uc002jul.1_Missense_Mutation_p.A431G|TMC6_uc002jum.2_Missense_Mutation_p.A222G|TMC6_uc002jun.2_Missense_Mutation_p.A431G|TMC6_uc002juo.2_Missense_Mutation_p.A204G	NM_007267	NP_009198	Q7Z403	TMC6_HUMAN	transmembrane channel-like 6	431	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane					0														0.444444	7.95055	7.980935	4	5	GG		KEEP	---	---	---	---	capture	BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)		Missense_Mutation	SNP	73629323	73629323	16519	17	G	C	C	38	38	TMC6	C	3	3
DSC3	1825	broad.mit.edu	36	18	26838254	26838254	+	Silent	SNP	C	T	T			TCGA-06-0646-01	TCGA-06-0646-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr18:26838254C>T	uc002kwj.2	-	c.1965G>A	c.(1963-1965)AGG>AGA	p.R655R	DSC3_uc002kwi.2_Silent_p.R655R	NM_001941	NP_001932	Q14574	DSC3_HUMAN	desmocollin 3 isoform Dsc3a preproprotein	655	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			ovary(2)	2														0.345679	167.316969	170.692864	56	106	CC		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(10;0.125)		Silent	SNP	26838254	26838254	4951	18	C	T	T	22	22	DSC3	T	2	2
MUC16	94025	broad.mit.edu	36	19	8951417	8951417	+	Missense_Mutation	SNP	G	C	C			TCGA-06-0646-01	TCGA-06-0646-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr19:8951417G>C	uc002mkp.1	-	c.1398C>G	c.(1396-1398)AGC>AGG	p.S466R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	466	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			ovary(15)|large_intestine(1)|pancreas(1)|breast(1)|skin(1)	19														0.331104	328.289346	335.867224	99	200	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	8951417	8951417	10367	19	G	C	C	46	46	MUC16	C	3	3
FCRL2	79368	broad.mit.edu	36	1	155985303	155985303	+	Missense_Mutation	SNP	G	T	T			TCGA-06-0646-01	TCGA-06-0646-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:155985303G>T	uc001fre.1	-	c.1379C>A	c.(1378-1380)CCA>CAA	p.P460Q	FCRL2_uc001frd.1_Missense_Mutation_p.P207Q|FCRL2_uc009wsp.1_Missense_Mutation_p.P176Q	NM_030764	NP_110391	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2 isoform b	460	Cytoplasmic (Potential).|ITIM motif 2.				cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			ovary(1)|pancreas(1)	2	all_hematologic(112;0.0378)													0.402174	107.335158	108.110496	37	55	GG		KEEP	---	---	---	---	capture	LUSC - Lung squamous cell carcinoma(543;0.24)		Missense_Mutation	SNP	155985303	155985303	6032	1	G	T	T	47	47	FCRL2	T	3	3
CEP350	9857	broad.mit.edu	36	1	178232354	178232354	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0646-01	TCGA-06-0646-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:178232354G>A	uc001gnt.1	+	c.439G>A	c.(439-441)GAA>AAA	p.E147K	CEP350_uc001gnu.1_5'UTR|CEP350_uc001gnr.1_Missense_Mutation_p.E121K	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	147						centrosome|nucleus|spindle				ovary(4)	4														0.407407	34.720488	34.922618	11	16	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	178232354	178232354	3387	1	G	A	A	41	41	CEP350	A	2	2
RYR2	6262	broad.mit.edu	36	1	235869069	235869069	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0646-01	TCGA-06-0646-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:235869069G>A	uc001hyl.1	+	c.7060G>A	c.(7060-7062)GCC>ACC	p.A2354T		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2354	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)												0.34	46.858908	47.990752	17	33	GG		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(106;0.00606)		Missense_Mutation	SNP	235869069	235869069	14249	1	G	A	A	38	38	RYR2	A	1	1
LCK	3932	broad.mit.edu	36	1	32512598	32512598	+	Silent	SNP	A	T	T			TCGA-06-0646-01	TCGA-06-0646-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr1:32512598A>T	uc001buz.1	+	c.81A>T	c.(79-81)ATA>ATT	p.I27I	LCK_uc001bux.1_Silent_p.I27I|LCK_uc001buy.1_Silent_p.I27I|LCK_uc001bva.1_Silent_p.I27I	NM_005356	NP_005347	P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase	27	Interactions with CD4 and CD8 (By similarity).				activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			central_nervous_system(2)|ovary(1)|lung(1)	4		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)					146				0.39823	135.950902	136.975068	45	68	AA		KEEP	---	---	---	---	capture			Silent	SNP	32512598	32512598	9000	1	A	T	T	15	15	LCK	T	4	4
AKR1A1	10327	broad.mit.edu	36	1	45800057	45800057	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0646-01	TCGA-06-0646-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:45800057G>A	uc001cod.1	+	c.4G>A	c.(4-6)GCG>ACG	p.A2T	AKR1A1_uc009vxw.1_Missense_Mutation_p.A2T|AKR1A1_uc001coe.1_Missense_Mutation_p.A2T	NM_006066	NP_697021	P14550	AK1A1_HUMAN	aldo-keto reductase family 1, member A1	2					glucose metabolic process|oxidation-reduction process		alcohol dehydrogenase (NADP+) activity|alditol:NADP+ 1-oxidoreductase activity|electron carrier activity|protein binding				0	Acute lymphoblastic leukemia(166;0.155)													0.459302	244.104396	244.352902	79	93	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	45800057	45800057	468	1	G	A	A	42	42	AKR1A1	A	2	2
CCDC17	149483	broad.mit.edu	36	1	45859162	45859162	+	Silent	SNP	C	T	T			TCGA-06-0646-01	TCGA-06-0646-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:45859162C>T	uc009vxy.1	-	c.1503G>A	c.(1501-1503)CAG>CAA	p.Q501Q	CCDC17_uc001com.2_Silent_p.Q354Q|CCDC17_uc001con.2_Non-coding_Transcript|CCDC17_uc009vxz.1_Intron	NM_001114938	NP_001108410	Q96LX7	CCD17_HUMAN	coiled-coil domain containing 17	533										ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)													0.217391	11.357092	13.057818	5	18	CC		KEEP	---	---	---	---	capture			Silent	SNP	45859162	45859162	2915	1	C	T	T	24	24	CCDC17	T	2	2
REM1	28954	broad.mit.edu	36	20	29535842	29535842	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0646-01	TCGA-06-0646-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr20:29535842G>A	uc002wwa.1	+	c.845G>A	c.(844-846)CGC>CAC	p.R282H		NM_014012	NP_054731	O75628	REM1_HUMAN	RAS-like GTP-binding protein REM	282	Arg-rich.|Calmodulin-binding (By similarity).				small GTPase mediated signal transduction	membrane	calmodulin binding|GTP binding|GTPase activity			pancreas(2)	2	all_cancers(5;0.000119)|Lung NSC(7;1.32e-05)|all_lung(7;2.14e-05)|all_hematologic(12;0.158)|Ovarian(7;0.198)									265				0.666667	12.002099	12.151745	4	2	GG		KEEP	---	---	---	---	capture	Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)		Missense_Mutation	SNP	29535842	29535842	13691	20	G	A	A	38	38	REM1	A	1	1
HCK	3055	broad.mit.edu	36	20	30152895	30152895	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0646-01	TCGA-06-0646-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr20:30152895C>T	uc002wxh.1	+	c.1493C>T	c.(1492-1494)CCG>CTG	p.P498L	HCK_uc010gdy.1_Missense_Mutation_p.P477L|HCK_uc002wxi.1_Missense_Mutation_p.P476L	NM_002110	NP_002101	P08631	HCK_HUMAN	hemopoietic cell kinase isoform p61HCK	498	Protein kinase.				interspecies interaction between organisms|mesoderm development|protein phosphorylation|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding	p.P477L(1)		lung(4)|ovary(2)|central_nervous_system(2)|pancreas(1)	9										262				0.441558	106.947262	107.174886	34	43	CC		KEEP	---	---	---	---	capture	UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)		Missense_Mutation	SNP	30152895	30152895	7276	20	C	T	T	23	23	HCK	T	1	1
APPL1	26060	broad.mit.edu	36	3	57277533	57277533	+	Missense_Mutation	SNP	A	G	G			TCGA-06-0646-01	TCGA-06-0646-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr3:57277533A>G	uc003dio.1	+	c.1961A>G	c.(1960-1962)AAT>AGT	p.N654S	ASB14_uc003dip.1_3'UTR|ASB14_uc003diq.1_3'UTR	NM_012096	NP_036228	Q9UKG1	DP13A_HUMAN	adaptor protein, phosphotyrosine interaction, PH	654	PID.|Potential.				apoptosis|cell cycle|cell proliferation|insulin receptor signaling pathway|regulation of apoptosis|regulation of establishment of protein localization in plasma membrane|regulation of glucose import	cytosol|early endosome membrane|microsome|nucleus|vesicle membrane	protein kinase B binding			breast(1)	1														0.363636	70.887413	71.786353	20	35	AA		KEEP	---	---	---	---	capture		KIRC - Kidney renal clear cell carcinoma(284;0.0124)|Kidney(284;0.0144)	Missense_Mutation	SNP	57277533	57277533	828	3	A	G	G	4	4	APPL1	G	4	4
MAGI1	9223	broad.mit.edu	36	3	65317685	65317685	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0646-01	TCGA-06-0646-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr3:65317685G>A	uc003dmn.1	-	c.3797C>T	c.(3796-3798)CCG>CTG	p.P1266L	MAGI1_uc003dmm.1_3'UTR	NM_001033057	NP_001028229	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ	1295					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			kidney(1)|pancreas(1)	2		Lung NSC(201;0.0016)												0.356757	197.751144	201.071884	66	119	GG		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)	Missense_Mutation	SNP	65317685	65317685	9573	3	G	A	A	39	39	MAGI1	A	1	1
USP38	84640	broad.mit.edu	36	4	144360969	144360969	+	Silent	SNP	A	T	T			TCGA-06-0646-01	TCGA-06-0646-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr4:144360969A>T	uc003ijb.1	+	c.3039A>T	c.(3037-3039)GGA>GGT	p.G1013G	USP38_uc003ijc.1_Non-coding_Transcript	NM_032557	NP_115946	Q8NB14	UBP38_HUMAN	ubiquitin specific peptidase 38	1013					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(1)|lung(1)|pancreas(1)	3	all_hematologic(180;0.158)													0.40146	169.403103	170.564478	55	82	AA		KEEP	---	---	---	---	capture			Silent	SNP	144360969	144360969	17633	4	A	T	T	12	12	USP38	T	4	4
CLOCK	9575	broad.mit.edu	36	4	56043698	56043698	+	Silent	SNP	G	A	A			TCGA-06-0646-01	TCGA-06-0646-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr4:56043698G>A	uc003haz.1	-	c.12C>T	c.(10-12)ACC>ACT	p.T4T	CLOCK_uc003hba.1_Silent_p.T4T	NM_004898	NP_004889	O15516	CLOCK_HUMAN	clock	4					circadian rhythm|photoperiodism|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|transcription factor complex	DNA binding|histone acetyltransferase activity|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription regulator activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(11;0.00335)|Glioma(25;0.08)|all_epithelial(27;0.0992)|all_neural(26;0.101)													0.344262	65.368892	66.669806	21	40	GG		KEEP	---	---	---	---	capture	LUSC - Lung squamous cell carcinoma(4;1.62e-07)|Lung(4;1.34e-06)|Epithelial(7;0.0107)		Silent	SNP	56043698	56043698	3687	4	G	A	A	39	39	CLOCK	A	1	1
SORCS2	57537	broad.mit.edu	36	4	7770728	7770728	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0646-01	TCGA-06-0646-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr4:7770728G>A	uc003gkb.2	+	c.2342G>A	c.(2341-2343)CGG>CAG	p.R781Q		NM_020777	NP_065828	Q96PQ0	SORC2_HUMAN	VPS10 domain receptor protein SORCS 2	781	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(1)|central_nervous_system(1)	2														0.423077	32.921026	33.055131	11	15	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	7770728	7770728	15431	4	G	A	A	39	39	SORCS2	A	1	1
PCDHB6	56130	broad.mit.edu	36	5	140512213	140512213	+	Missense_Mutation	SNP	C	G	G			TCGA-06-0646-01	TCGA-06-0646-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr5:140512213C>G	uc003lir.1	+	c.2191C>G	c.(2191-2193)CCA>GCA	p.P731A		NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	731	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding				0														0.273026	253.19977	267.307714	83	221	CC		KEEP	---	---	---	---	capture	KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)		Missense_Mutation	SNP	140512213	140512213	11966	5	C	G	G	30	30	PCDHB6	G	3	3
GPR6	2830	broad.mit.edu	36	6	110407748	110407748	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0646-01	TCGA-06-0646-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr6:110407748G>A	uc003ptu.1	+	c.740G>A	c.(739-741)CGC>CAC	p.R247H		NM_005284	NP_005275	P46095	GPR6_HUMAN	G protein-coupled receptor 6	247	Helical; Name=5; (Potential).					integral to plasma membrane					0		all_cancers(87;1.64e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;2.83e-05)|all_lung(197;0.00016)|Lung NSC(302;0.000318)|Colorectal(196;0.0488)												0.428571	64.068689	64.286349	21	28	GG		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(108;8.01e-05)|Epithelial(106;8.76e-05)|all cancers(137;0.000197)|OV - Ovarian serous cystadenocarcinoma(136;0.0307)	Missense_Mutation	SNP	110407748	110407748	6976	6	G	A	A	38	38	GPR6	A	1	1
RELN	5649	broad.mit.edu	36	7	102978945	102978945	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0646-01	TCGA-06-0646-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr7:102978945G>A	uc003vca.1	-	c.6107C>T	c.(6106-6108)GCG>GTG	p.A2036V	RELN_uc010liz.1_Missense_Mutation_p.A2036V	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2036					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|large_intestine(2)|central_nervous_system(2)|pancreas(1)|skin(1)	14						NSCLC(146;835 1944 15585 22231 52158)								0.287671	52.43964	55.394946	21	52	GG		KEEP	---	---	---	---	capture		COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)	Missense_Mutation	SNP	102978945	102978945	13689	7	G	A	A	38	38	RELN	A	1	1
KEL	3792	broad.mit.edu	36	7	142350111	142350111	+	Silent	SNP	G	A	A			TCGA-06-0646-01	TCGA-06-0646-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr7:142350111G>A	uc003wcb.1	-	c.1914C>T	c.(1912-1914)GAC>GAT	p.D638D		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	638	Extracellular (Potential).	Proton donor (By similarity).			proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)													0.340782	337.277854	345.281038	122	236	GG		KEEP	---	---	---	---	capture			Silent	SNP	142350111	142350111	8448	7	G	A	A	40	40	KEL	A	1	1
SEMA3C	10512	broad.mit.edu	36	7	80271429	80271429	+	Missense_Mutation	SNP	A	G	G			TCGA-06-0646-01	TCGA-06-0646-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr7:80271429A>G	uc003uhj.1	-	c.730T>C	c.(730-732)TTC>CTC	p.F244L		NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C	244	Sema.				immune response|response to drug	membrane	receptor activity			ovary(1)	1														0.243478	85.444059	92.339702	28	87	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	80271429	80271429	14512	7	A	G	G	3	3	SEMA3C	G	4	4
COL1A2	1278	broad.mit.edu	36	7	93875479	93875479	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0646-01	TCGA-06-0646-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr7:93875479C>T	uc003ung.1	+	c.688C>T	c.(688-690)CCA>TCA	p.P230S		NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen	230					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging	p.P230S(1)		central_nervous_system(3)|ovary(2)	5	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)				Collagenase(DB00048)									0.276382	150.981844	159.914381	55	144	CC		KEEP	---	---	---	---	capture	STAD - Stomach adenocarcinoma(171;0.0031)		Missense_Mutation	SNP	93875479	93875479	3816	7	C	T	T	22	22	COL1A2	T	2	2
TRRAP	8295	broad.mit.edu	36	7	98390806	98390806	+	Silent	SNP	G	A	A			TCGA-06-0646-01	TCGA-06-0646-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr7:98390806G>A	uc003upp.1	+	c.5859G>A	c.(5857-5859)GAG>GAA	p.E1953E	TRRAP_uc003upq.1_Silent_p.E1935E|TRRAP_uc003upr.1_Silent_p.E1652E	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	1953					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity	p.E1935E(1)		ovary(9)|large_intestine(8)|central_nervous_system(6)|stomach(2)|lung(1)|liver(1)	27	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)									1847				0.247934	79.489829	86.484847	30	91	GG		KEEP	---	---	---	---	capture	STAD - Stomach adenocarcinoma(171;0.215)		Silent	SNP	98390806	98390806	17152	7	G	A	A	35	35	TRRAP	A	2	2
COL22A1	169044	broad.mit.edu	36	8	139675519	139675519	+	Missense_Mutation	SNP	C	T	T			TCGA-06-0646-01	TCGA-06-0646-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr8:139675519C>T	uc003yvd.1	-	c.4538G>A	c.(4537-4539)CGG>CAG	p.R1513Q	COL22A1_uc003yvc.1_Missense_Mutation_p.R631Q	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1513	Pro-rich.|Gly-rich.|Collagen-like 15.				cell adhesion	collagen|cytoplasm	structural molecule activity	p.R1513Q(1)		ovary(10)|pancreas(1)	11	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)													0.356643	149.710968	152.288351	51	92	CC		KEEP	---	---	---	---	capture	BRCA - Breast invasive adenocarcinoma(115;0.0517)		Missense_Mutation	SNP	139675519	139675519	3819	8	C	T	T	23	23	COL22A1	T	1	1
NAPRT1	93100	broad.mit.edu	36	8	144728541	144728541	+	Missense_Mutation	SNP	A	C	C			TCGA-06-0646-01	TCGA-06-0646-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr8:144728541A>C	uc003yyo.2	-	c.1409T>G	c.(1408-1410)GTG>GGG	p.V470G	C8orf73_uc010mff.1_5'Flank|C8orf73_uc010mfg.1_5'Flank|NAPRT1_uc003yyl.1_Missense_Mutation_p.V446G|NAPRT1_uc003yym.2_Missense_Mutation_p.V470G|NAPRT1_uc003yyn.2_Splice_Site_SNP_p.Q469_splice	NM_145201	NP_660202	Q6XQN6	PNCB_HUMAN	nicotinate phosphoribosyltransferase domain	470					nicotinamide metabolic process|nicotinate nucleotide salvage|response to oxidative stress	cytosol|Golgi apparatus|nucleus	nicotinate phosphoribosyltransferase activity|nicotinate-nucleotide diphosphorylase (carboxylating) activity			ovary(1)	1	all_cancers(97;6.49e-11)|all_epithelial(106;4.73e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.014)|Acute lymphoblastic leukemia(118;0.155)									3				0.352941	6.488053	6.925544	6	11	AA		KEEP	---	---	---	---	capture	Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.146)		Missense_Mutation	SNP	144728541	144728541	10561	8	A	C	C	6	6	NAPRT1	C	4	4
SOHLH1	402381	broad.mit.edu	36	9	137725346	137725346	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0646-01	TCGA-06-0646-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr9:137725346G>A	uc010nbe.1	-	c.1082C>T	c.(1081-1083)CCG>CTG	p.P361L	SOHLH1_uc004cgl.1_3'UTR	NM_001101677	NP_001095147	Q5JUK2	SOLH1_HUMAN	spermatogenesis and oogenesis specific basic	Error:Variant_position_missing_in_Q5JUK2_after_alignment					cell differentiation|multicellular organismal development|oogenesis|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|transcription regulator activity			breast(1)|central_nervous_system(1)	2		Myeloproliferative disorder(178;0.0511)												0.416667	16.57431	16.64669	5	7	GG		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(145;1.66e-07)|Epithelial(140;1.11e-06)|all cancers(34;6.45e-05)	Missense_Mutation	SNP	137725346	137725346	15423	9	G	A	A	39	39	SOHLH1	A	1	1
ZNF322B	387328	broad.mit.edu	36	9	99000481	99000481	+	Silent	SNP	C	T	T			TCGA-06-0646-01	TCGA-06-0646-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr9:99000481C>T	uc004axd.1	-	c.1134G>A	c.(1132-1134)CCG>CCA	p.P378P	ZNF322B_uc004axc.1_5'Flank	NM_199005	NP_945356	Q5SYY0	Z322B_HUMAN	zinc finger protein 322B	378					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Acute lymphoblastic leukemia(62;0.158)												0.361502	446.026461	453.221156	154	272	CC		KEEP	---	---	---	---	capture			Silent	SNP	99000481	99000481	18434	9	C	T	T	19	19	ZNF322B	T	1	1
KIF4A	24137	broad.mit.edu	36	X	69489226	69489226	+	Missense_Mutation	SNP	G	A	A			TCGA-06-0646-01	TCGA-06-0646-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chrX:69489226G>A	uc004dyg.1	+	c.1483G>A	c.(1483-1485)GAA>AAA	p.E495K	KIF4A_uc004dyf.1_Missense_Mutation_p.E495K|KIF4A_uc010nkw.1_Missense_Mutation_p.E495K	NM_012310	NP_036442	O95239	KIF4A_HUMAN	kinesin family member 4	495	Potential.				anterograde axon cargo transport|axon guidance|blood coagulation|organelle organization	chromosome|cytosol|midbody|nuclear matrix|spindle microtubule	ATP binding|DNA binding|microtubule motor activity|protein binding			ovary(4)	4														0.205882	10.292562	13.052706	7	27	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	69489226	69489226	8614	23	G	A	A	33	33	KIF4A	A	2	2
HYOU1	10525	broad.mit.edu	36	11	118424259	118424259	+	Frame_Shift_Del	DEL	A	-	-			TCGA-06-0646-01	TCGA-06-0646-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:118424259_118424259delA	uc001puu.2	-	c.2287_2287delT	c.(2287-2289)TCCfs	p.S763fs	HYOU1_uc001put.2_Frame_Shift_Del_p.S728fs	NM_006389	NP_006380	Q9Y4L1	HYOU1_HUMAN	hypoxia up-regulated 1 precursor	763						endoplasmic reticulum lumen	ATP binding|protein binding				0	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)|all_hematologic(192;0.207)		BRCA - Breast invasive adenocarcinoma(274;7.78e-05)										0.36			109	195				---	---	---	---	capture_indel			Frame_Shift_Del	DEL	118424259	118424259	7770	11	A	-	-	10	10	HYOU1	-	5	5
ZNF571	51276	broad.mit.edu	36	19	42748030	42748033	+	Frame_Shift_Del	DEL	GTAA	-	-			TCGA-06-0646-01	TCGA-06-0646-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:42748030_42748033delGTAA	uc002ogt.1	-	c.1137_1140delTTAC	c.(1135-1140)ACTTACfs	p.T379fs	ZNF540_uc002ogo.2_Intron|ZNF540_uc002ogp.2_Intron|ZNF540_uc002ogq.1_Intron|ZNF571_uc002ogr.1_Intron|ZNF571_uc010efp.1_Frame_Shift_Del_p.T379fs	NM_016536	NP_057620	Q7Z3V5	ZN571_HUMAN	zinc finger protein 571	379_380	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)											0.38			37	61				---	---	---	---	capture_indel			Frame_Shift_Del	DEL	42748030	42748033	18598	19	GTAA	-	-	44	44	ZNF571	-	5	5
CDKN2C	1031	broad.mit.edu	36	1	51208671	51208671	+	Frame_Shift_Del	DEL	A	-	-			TCGA-06-0646-01	TCGA-06-0646-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:51208671_51208671delA	uc001csf.1	+	c.43_43delA	c.(43-45)AGGfs	p.R15fs	CDKN2C_uc001csg.1_Frame_Shift_Del_p.R15fs	NM_001262	NP_523240	P42773	CDN2C_HUMAN	cyclin-dependent kinase inhibitor 2C	15	ANK 1.				cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|protein kinase binding	p.0?(6)|p.R15fs*4(1)		central_nervous_system(7)|haematopoietic_and_lymphoid_tissue(5)|ovary(2)|thyroid(1)|lung(1)|kidney(1)	17				GBM - Glioblastoma multiforme(3;3.61e-13)|all cancers(3;0.00151)		Melanoma(47;50 1155 4767 22863 47597)			p.R15fs(EN-Tumor)	40				0.60			41	27				---	---	---	---	capture_indel			Frame_Shift_Del	DEL	51208671	51208671	3294	1	A	-	-	7	7	CDKN2C	-	5	5
