Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	i_TCGAscape_Amplification_Peaks	i_TCGAscape_Deletion_Peaks	DrugBank	i_ACHILLES_Top_Genes	i_CCLE_ONCOMAP_overlapping_mutations	i_CCLE_ONCOMAP_total_mutations_in_gene	i_CCLE_SEQ_overlapping_mutations	i_CCLE_SEQ_total_mutations_in_gene	MUTSIG_Significant_Genes	OREGANNO_ID	OREGANNO_Values	i_tumor_f	i_init_t_lod	i_t_lod_fstar	i_t_alt_count	i_t_ref_count	i_normal_best_gt	i_failure_reasons	i_judgement	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	dataset	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	type	classification	start	end	gene	chr	ref_allele	tum_allele1	tum_allele2	context_orig	context65	gene_name	newbase	categ	categ_ignoring_null_categ
LHPP	64077	broad.mit.edu	36	10	126162706	126162706	+	Missense_Mutation	SNP	G	A	A			TCGA-06-2569-01	TCGA-06-2569-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr10:126162706G>A	uc001lhs.1	+	c.134G>A	c.(133-135)CGT>CAT	p.R45H	LHPP_uc001lht.1_Missense_Mutation_p.R45H|LHPP_uc009yai.1_Missense_Mutation_p.R45H	NM_022126	NP_071409	Q9H008	LHPP_HUMAN	phospholysine phosphohistidine inorganic	45							inorganic diphosphatase activity				0		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)				GBM(165;1980 2715 15999 18454)								0.190476	16.180031	19.938612	8	34	GG		KEEP	---	---	---	---	capture		COAD - Colon adenocarcinoma(40;0.163)|Colorectal(40;0.187)	Missense_Mutation	SNP	126162706	126162706	9095	10	G	A	A	40	40	LHPP	A	1	1
GJD4	219770	broad.mit.edu	36	10	35936767	35936767	+	Missense_Mutation	SNP	G	C	C			TCGA-06-2569-01	TCGA-06-2569-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr10:35936767G>C	uc001iyy.1	+	c.320G>C	c.(319-321)GGC>GCC	p.G107A		NM_153368	NP_699199	Q96KN9	CXD4_HUMAN	connexin40.1	107	Cytoplasmic (Potential).				cell communication	connexon complex|integral to membrane				large_intestine(2)|central_nervous_system(1)|pancreas(1)	4														0.25	7.681002	10.146571	10	30	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	35936767	35936767	6687	10	G	C	C	42	42	GJD4	C	3	3
RAG1	5896	broad.mit.edu	36	11	36552605	36552605	+	Missense_Mutation	SNP	G	T	T			TCGA-06-2569-01	TCGA-06-2569-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr11:36552605G>T	uc001mwu.2	+	c.1175G>T	c.(1174-1176)GGG>GTG	p.G392V	RAG1_uc001mwt.2_Non-coding_Transcript|RAG1_uc009ykl.1_Missense_Mutation_p.G392V	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	392	NBD.				histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4	all_lung(20;0.226)	all_hematologic(20;0.107)				Pancreas(43;321 1249 3212 48200)|Esophageal Squamous(38;49 1003 17530 24363)				117				0.440367	132.291942	132.627353	48	61	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	36552605	36552605	13463	11	G	T	T	43	43	RAG1	T	3	3
MAP6	4135	broad.mit.edu	36	11	74994550	74994550	+	Missense_Mutation	SNP	C	T	T			TCGA-06-2569-01	TCGA-06-2569-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr11:74994550C>T	uc001owu.1	-	c.1267G>A	c.(1267-1269)GAC>AAC	p.D423N	MAP6_uc001owv.1_Missense_Mutation_p.D423N	NM_033063	NP_149052	Q96JE9	MAP6_HUMAN	microtubule-associated protein 6 isoform 1	423						Golgi apparatus|microtubule|perinuclear region of cytoplasm	calmodulin binding				0	Ovarian(111;0.11)					Esophageal Squamous(181;1115 2007 8647 17065 22697)								0.44	299.897597	300.601196	99	126	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	74994550	74994550	9647	11	C	T	T	31	31	MAP6	T	1	1
IRAK4	51135	broad.mit.edu	36	12	42452373	42452373	+	Missense_Mutation	SNP	G	T	T			TCGA-06-2569-01	TCGA-06-2569-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr12:42452373G>T	uc001rnu.2	+	c.431G>T	c.(430-432)AGC>ATC	p.S144I	IRAK4_uc001rnt.2_Missense_Mutation_p.S144I|IRAK4_uc001rnv.2_Missense_Mutation_p.S20I|IRAK4_uc001rnw.2_Missense_Mutation_p.S20I|IRAK4_uc001rnx.2_Missense_Mutation_p.S20I|IRAK4_uc001rny.2_Missense_Mutation_p.S20I	NM_001114182	NP_001107654	Q9NWZ3	IRAK4_HUMAN	interleukin-1 receptor-associated kinase 4	144					innate immune response|MyD88-dependent toll-like receptor signaling pathway|protein phosphorylation|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity				0	all_cancers(12;0.00149)	Lung NSC(34;0.0804)|all_lung(34;0.181)								243				0.266409	175.453572	188.224315	69	190	GG		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(48;0.04)	Missense_Mutation	SNP	42452373	42452373	8128	12	G	T	T	34	34	IRAK4	T	3	3
TMBIM4	51643	broad.mit.edu	36	12	64833494	64833494	+	Silent	SNP	G	A	A			TCGA-06-2569-01	TCGA-06-2569-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr12:64833494G>A	uc009zqr.1	-	c.240C>T	c.(238-240)ACC>ACT	p.T80T	TMBIM4_uc001stc.1_Silent_p.A33A|TMBIM4_uc001std.1_Intron|TMBIM4_uc001ste.1_Non-coding_Transcript|TMBIM4_uc001stf.1_Silent_p.A33A|TMBIM4_uc009zqs.1_Silent_p.A33A	NM_016056	NP_057140	Q9HC24	TMBI4_HUMAN	transmembrane BAX inhibitor motif containing 4	33						integral to membrane	protein binding			ovary(1)|central_nervous_system(1)	2														0.598592	293.202121	294.408835	85	57	GG		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(28;0.0745)	Silent	SNP	64833494	64833494	16512	12	G	A	A	35	35	TMBIM4	A	2	2
ATP12A	479	broad.mit.edu	36	13	24181590	24181590	+	Missense_Mutation	SNP	A	C	C			TCGA-06-2569-01	TCGA-06-2569-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr13:24181590A>C	uc010aaa.1	+	c.2600A>C	c.(2599-2601)AAC>ACC	p.N867T	ATP12A_uc001upp.1_Missense_Mutation_p.N861T	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	861	Helical; (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)			Esomeprazole(DB00736)|Pantoprazole(DB00213)	Pancreas(156;1582 1935 18898 22665 26498)								0.3	8.576032	9.40559	6	14	AA		KEEP	---	---	---	---	capture		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Missense_Mutation	SNP	24181590	24181590	1141	13	A	C	C	2	2	ATP12A	C	4	4
WDFY2	115825	broad.mit.edu	36	13	51132798	51132798	+	Missense_Mutation	SNP	C	G	G			TCGA-06-2569-01	TCGA-06-2569-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr13:51132798C>G	uc001vfp.1	+	c.203C>G	c.(202-204)CCT>CGT	p.P68R	WDFY2_uc010ads.1_Missense_Mutation_p.P68R|WDFY2_uc010adt.1_Non-coding_Transcript	NM_052950	NP_443182	Q96P53	WDFY2_HUMAN	WD repeat and FYVE domain containing 2	68	WD 2.						zinc ion binding				0		Breast(56;0.000208)|Lung NSC(96;0.000517)|Prostate(109;0.0041)|Hepatocellular(98;0.0652)|Myeloproliferative disorder(33;0.164)|all_neural(104;0.191)												0.140845	30.7259	48.389837	20	122	CC		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(99;9e-08)	Missense_Mutation	SNP	51132798	51132798	17841	13	C	G	G	24	24	WDFY2	G	3	3
DICER1	23405	broad.mit.edu	36	14	94630229	94630229	+	Missense_Mutation	SNP	C	G	G			TCGA-06-2569-01	TCGA-06-2569-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr14:94630229C>G	uc001ydw.2	-	c.5113G>C	c.(5113-5115)GAA>CAA	p.E1705Q	DICER1_uc010avh.1_Missense_Mutation_p.E603Q|DICER1_uc001ydv.2_Missense_Mutation_p.E1695Q|DICER1_uc001ydx.2_Missense_Mutation_p.E1705Q	NM_030621	NP_803187	Q9UPY3	DICER_HUMAN	dicer1	1705	RNase III 2.	Magnesium or manganese 2.			negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-microRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			ovary(1)|pancreas(1)|lung(1)|skin(1)	4		all_cancers(154;0.0621)|all_epithelial(191;0.223)								741				0.473214	180.762213	180.832525	53	59	CC		KEEP	---	---	---	---	capture		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)	Missense_Mutation	SNP	94630229	94630229	4700	14	C	G	G	32	32	DICER1	G	3	3
ITGAD	3681	broad.mit.edu	36	16	31329598	31329598	+	Missense_Mutation	SNP	C	A	A			TCGA-06-2569-01	TCGA-06-2569-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr16:31329598C>A	uc010cap.1	+	c.1254C>A	c.(1252-1254)AAC>AAA	p.N418K	ITGAD_uc002ebv.1_Missense_Mutation_p.N418K	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor	418	FG-GAP 4.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1														0.861111	207.457361	216.5148	62	10	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	31329598	31329598	8188	16	C	A	A	18	18	ITGAD	A	3	3
EVI2B	2124	broad.mit.edu	36	17	26655810	26655810	+	Missense_Mutation	SNP	C	G	G			TCGA-06-2569-01	TCGA-06-2569-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr17:26655810C>G	uc002hgk.2	-	c.944G>C	c.(943-945)GGT>GCT	p.G315A	NF1_uc002hgg.1_Intron|NF1_uc002hgh.1_Intron|NF1_uc002hgi.1_Intron|NF1_uc010cso.1_Intron|EVI2B_uc010csq.1_Missense_Mutation_p.G315A	NM_006495	NP_006486	P34910	EVI2B_HUMAN	ecotropic viral integration site 2B	315	Cytoplasmic (Potential).					cytoplasm|integral to plasma membrane		p.?(1)		ovary(2)	2		all_cancers(10;6.97e-11)|all_epithelial(10;0.0051)|all_hematologic(16;0.0149)|Breast(31;0.0155)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|all_lung(9;0.0468)|Lung NSC(157;0.094)												0.444444	319.595214	320.148077	92	115	CC		KEEP	---	---	---	---	capture		UCEC - Uterine corpus endometrioid carcinoma (4;6.64e-05)|all cancers(4;6.88e-13)|Epithelial(4;8.95e-12)|OV - Ovarian serous cystadenocarcinoma(4;1.01e-11)|GBM - Glioblastoma multiforme(4;0.184)	Missense_Mutation	SNP	26655810	26655810	5481	17	C	G	G	18	18	EVI2B	G	3	3
GAS2L2	246176	broad.mit.edu	36	17	31097234	31097234	+	Silent	SNP	G	A	A			TCGA-06-2569-01	TCGA-06-2569-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr17:31097234G>A	uc002hjv.1	-	c.1395C>T	c.(1393-1395)GCC>GCT	p.A465A		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	465					cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)												0.390728	177.308155	178.88111	59	92	GG		KEEP	---	---	---	---	capture		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)	Silent	SNP	31097234	31097234	6511	17	G	A	A	39	39	GAS2L2	A	1	1
ACACA	31	broad.mit.edu	36	17	32518368	32518368	+	Missense_Mutation	SNP	G	A	A			TCGA-06-2569-01	TCGA-06-2569-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr17:32518368G>A	uc002hno.1	-	c.7148C>T	c.(7147-7149)ACG>ATG	p.T2383M	ACACA_uc002hnk.1_Missense_Mutation_p.T2268M|ACACA_uc002hnl.1_Missense_Mutation_p.T2288M|ACACA_uc002hnm.1_Missense_Mutation_p.T2346M|ACACA_uc002hnn.1_Missense_Mutation_p.T2346M|ACACA_uc010cuy.1_Missense_Mutation_p.T991M	NM_198834	NP_942135	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 1	2346					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	Colon(23;82 258 739 2117 10493 24037 27661 34815 35438 36249)				742				0.85	160.830201	167.867892	51	9	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	32518368	32518368	107	17	G	A	A	40	40	ACACA	A	1	1
FADS6	283985	broad.mit.edu	36	17	70387205	70387205	+	Missense_Mutation	SNP	G	C	C			TCGA-06-2569-01	TCGA-06-2569-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr17:70387205G>C	uc002jmd.1	-	c.830C>G	c.(829-831)GCG>GGG	p.A277G		NM_178128	NP_835229	Q8N9I5	FADS6_HUMAN	fatty acid desaturase domain family, member 6	283	Helical; (Potential).				fatty acid biosynthetic process|oxidation-reduction process	integral to membrane	oxidoreductase activity				0	all_lung(278;0.172)|Lung NSC(278;0.207)													0.155172	19.049223	25.628047	9	49	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	70387205	70387205	5565	17	G	C	C	38	38	FADS6	C	3	3
KLK15	55554	broad.mit.edu	36	19	56022002	56022002	+	Missense_Mutation	SNP	C	A	A			TCGA-06-2569-01	TCGA-06-2569-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr19:56022002C>A	uc002ptl.1	-	c.425G>T	c.(424-426)GGC>GTC	p.G142V	KLK15_uc002ptn.1_Missense_Mutation_p.G142V|KLK15_uc002ptm.1_Intron|KLK15_uc002pto.1_Missense_Mutation_p.G141V|KLK15_uc010eod.1_Non-coding_Transcript	NM_017509	NP_059979	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15 isoform 4	142	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)|breast(1)	2		all_neural(266;0.057)				Pancreas(140;10 2513 7143 9246)								0.25	32.924261	36.105387	14	42	CC		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)	Missense_Mutation	SNP	56022002	56022002	8717	19	C	A	A	26	26	KLK15	A	3	3
COL5A3	50509	broad.mit.edu	36	19	9938029	9938029	+	Silent	SNP	T	C	C			TCGA-06-2569-01	TCGA-06-2569-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr19:9938029T>C	uc002mmq.1	-	c.4743A>G	c.(4741-4743)GGA>GGG	p.G1581G		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	1581	Fibrillar collagen NC1.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)	9														0.421053	7.665697	7.810955	8	11	TT		KEEP	---	---	---	---	capture	Epithelial(33;7.11e-05)		Silent	SNP	9938029	9938029	3836	19	T	C	C	54	54	COL5A3	C	4	4
TRIM46	80128	broad.mit.edu	36	1	153417232	153417232	+	Missense_Mutation	SNP	G	A	A			TCGA-06-2569-01	TCGA-06-2569-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:153417232G>A	uc001fhs.1	+	c.1040G>A	c.(1039-1041)AGC>AAC	p.S347N	TRIM46_uc009wpe.1_Non-coding_Transcript|TRIM46_uc001fhq.2_Non-coding_Transcript|TRIM46_uc001fhr.2_Missense_Mutation_p.S347N|TRIM46_uc001fht.1_Non-coding_Transcript|TRIM46_uc001fhu.1_Missense_Mutation_p.S324N|TRIM46_uc001fhv.2_Missense_Mutation_p.S334N|TRIM46_uc009wpg.1_Missense_Mutation_p.S334N|TRIM46_uc001fhw.1_Non-coding_Transcript	NM_025058	NP_079334	Q7Z4K8	TRI46_HUMAN	tripartite motif-containing 46	347	Potential.					intracellular	zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)													0.361446	79.116835	80.523143	30	53	GG		KEEP	---	---	---	---	capture	Epithelial(20;6.62e-10)|all cancers(21;2.68e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)		Missense_Mutation	SNP	153417232	153417232	17066	1	G	A	A	34	34	TRIM46	A	2	2
IGSF8	93185	broad.mit.edu	36	1	158330466	158330466	+	Missense_Mutation	SNP	C	T	T			TCGA-06-2569-01	TCGA-06-2569-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:158330466C>T	uc001fuz.1	-	c.562G>A	c.(562-564)GCG>ACG	p.A188T	IGSF8_uc009wtf.1_Missense_Mutation_p.A188T|IGSF8_uc001fva.2_Missense_Mutation_p.A188T	NM_052868	NP_443100	Q969P0	IGSF8_HUMAN	immunoglobulin superfamily, member 8	188	Extracellular (Potential).|Ig-like C2-type 2.				cell proliferation|cellular component movement|nervous system development|single fertilization|skeletal muscle tissue development	integral to membrane	protein binding				0	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)													0.293651	94.167133	98.946034	37	89	CC		KEEP	---	---	---	---	capture	BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)		Missense_Mutation	SNP	158330466	158330466	7905	1	C	T	T	26	26	IGSF8	T	2	2
GLIS1	148979	broad.mit.edu	36	1	53833087	53833087	+	Missense_Mutation	SNP	A	G	G			TCGA-06-2569-01	TCGA-06-2569-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr1:53833087A>G	uc001cvr.1	-	c.77T>C	c.(76-78)CTC>CCC	p.L26P		NM_147193	NP_671726	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	26					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|specific RNA polymerase II transcription factor activity|zinc ion binding				0														0.384615	16.872673	17.024174	5	8	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	53833087	53833087	6713	1	A	G	G	11	11	GLIS1	G	4	4
MANBAL	63905	broad.mit.edu	36	20	35378167	35378167	+	Missense_Mutation	SNP	A	G	G			TCGA-06-2569-01	TCGA-06-2569-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr20:35378167A>G	uc002xgu.1	+	c.193A>G	c.(193-195)AAG>GAG	p.K65E	MANBAL_uc002xgv.1_Missense_Mutation_p.K65E|MANBAL_uc002xgw.1_Non-coding_Transcript|MANBAL_uc010gfx.1_Non-coding_Transcript|MANBAL_uc010gfy.1_Non-coding_Transcript	NM_022077	NP_071360	Q9NQG1	MANBL_HUMAN	mannosidase, beta A, lysosomal-like	65						integral to membrane					0		Myeloproliferative disorder(115;0.00878)												0.25	78.452737	84.811201	28	84	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	35378167	35378167	9603	20	A	G	G	9	9	MANBAL	G	4	4
EEF1A2	1917	broad.mit.edu	36	20	61590726	61590726	+	Missense_Mutation	SNP	T	G	G			TCGA-06-2569-01	TCGA-06-2569-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr20:61590726T>G	uc002yfd.1	-	c.1253A>C	c.(1252-1254)TAC>TCC	p.Y418S	EEF1A2_uc002yfe.1_Missense_Mutation_p.Y418S|EEF1A2_uc010gkg.1_Intron	NM_001958	NP_001949	Q05639	EF1A2_HUMAN	eukaryotic translation elongation factor 1 alpha	418						nucleus	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0	all_cancers(38;9.45e-12)													0.269231	8.93185	10.342437	7	19	TT		KEEP	---	---	---	---	capture	BRCA - Breast invasive adenocarcinoma(10;1.22e-05)		Missense_Mutation	SNP	61590726	61590726	5111	20	T	G	G	57	57	EEF1A2	G	4	4
MPP4	58538	broad.mit.edu	36	2	202263206	202263206	+	Silent	SNP	A	G	G			TCGA-06-2569-01	TCGA-06-2569-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr2:202263206A>G	uc002uyk.2	-	c.243T>C	c.(241-243)GTT>GTC	p.V81V	MPP4_uc010ftj.1_Silent_p.V81V|MPP4_uc002uyj.2_Silent_p.V81V|MPP4_uc002uyl.2_Non-coding_Transcript|MPP4_uc010ftk.1_Silent_p.V81V|MPP4_uc002uym.1_Silent_p.V94V|MPP4_uc002uyn.2_Silent_p.V81V	NM_033066	NP_149055	Q96JB8	MPP4_HUMAN	membrane protein, palmitoylated 4	81						cytoplasm	protein binding				0														0.285714	6.791048	7.370795	4	10	AA		KEEP	---	---	---	---	capture			Silent	SNP	202263206	202263206	10128	2	A	G	G	9	9	MPP4	G	4	4
MUC20	200958	broad.mit.edu	36	3	196942220	196942220	+	Missense_Mutation	SNP	T	C	C			TCGA-06-2569-01	TCGA-06-2569-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr3:196942220T>C	uc010hzo.1	+	c.1487T>C	c.(1486-1488)CTG>CCG	p.L496P	MUC20_uc010hzp.1_Missense_Mutation_p.L461P	NM_152673	NP_689886	Q8N307	MUC20_HUMAN	mucin 20 isoform L	667	Interaction with MET.				protein homooligomerization	apical plasma membrane|basal plasma membrane|extracellular region|microvillus membrane					0	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)	Lung NSC(153;0.191)												0.388889	22.021388	22.215929	7	11	TT		KEEP	---	---	---	---	capture	Epithelial(36;1e-21)|all cancers(36;9.02e-20)|OV - Ovarian serous cystadenocarcinoma(49;1.6e-18)|Lung(62;0.000104)|LUSC - Lung squamous cell carcinoma(58;0.000128)	GBM - Glioblastoma multiforme(46;1.66e-05)	Missense_Mutation	SNP	196942220	196942220	10370	3	T	C	C	55	55	MUC20	C	4	4
ATP10D	57205	broad.mit.edu	36	4	47233660	47233660	+	Missense_Mutation	SNP	G	T	T			TCGA-06-2569-01	TCGA-06-2569-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr4:47233660G>T	uc003gxk.1	+	c.1344G>T	c.(1342-1344)ATG>ATT	p.M448I	ATP10D_uc003gxj.2_Missense_Mutation_p.M433I|ATP10D_uc003gxl.1_5'UTR	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	448	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3														0.173913	30.436443	39.680528	16	76	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	47233660	47233660	1137	4	G	T	T	47	47	ATP10D	T	3	3
ATP5I	521	broad.mit.edu	36	4	656298	656298	+	Missense_Mutation	SNP	T	C	C			TCGA-06-2569-01	TCGA-06-2569-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr4:656298T>C	uc003gas.1	-	c.201A>G	c.(199-201)ATA>ATG	p.I67M	ATP5I_uc003gar.1_Non-coding_Transcript|MYL5_uc003gat.1_5'Flank|MYL5_uc003gau.1_5'Flank	NM_007100	NP_009031	P56385	ATP5I_HUMAN	ATP synthase, H+ transporting, mitochondrial F0	67					ATP catabolic process|mitochondrial ATP synthesis coupled proton transport|respiratory electron transport chain		hydrogen ion transmembrane transporter activity				0														0.381579	98.669287	99.599512	29	47	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	656298	656298	1176	4	T	C	C	49	49	ATP5I	C	4	4
CCDC99	54908	broad.mit.edu	36	5	168963769	168963769	+	Missense_Mutation	SNP	A	G	G			TCGA-06-2569-01	TCGA-06-2569-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr5:168963769A>G	uc003mae.2	+	c.1798A>G	c.(1798-1800)ACC>GCC	p.T600A	CCDC99_uc010jjk.1_Missense_Mutation_p.T326A	NM_017785	NP_060255	Q96EA4	SPDLY_HUMAN	coiled-coil domain containing 99	600					cell division|establishment of mitotic spindle orientation|mitotic metaphase plate congression|mitotic prometaphase|protein localization to kinetochore	condensed chromosome outer kinetochore|cytosol|microtubule organizing center|nucleus|spindle pole	kinetochore binding|protein binding			ovary(1)|liver(1)	2	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)												0.217391	66.135278	74.702447	25	90	AA		KEEP	---	---	---	---	capture	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Missense_Mutation	SNP	168963769	168963769	3001	5	A	G	G	10	10	CCDC99	G	4	4
C6orf1	221491	broad.mit.edu	36	6	34322597	34322597	+	Missense_Mutation	SNP	G	T	T			TCGA-06-2569-01	TCGA-06-2569-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr6:34322597G>T	uc003ojf.1	-	c.152C>A	c.(151-153)ACC>AAC	p.T51N	C6orf1_uc003ojg.1_Missense_Mutation_p.T51N|C6orf1_uc003ojh.1_Missense_Mutation_p.T51N|C6orf1_uc003oji.1_Non-coding_Transcript	NM_178508	NP_848603	Q86T20	CF001_HUMAN	hypothetical protein LOC221491	51						extracellular region					0		Ovarian(999;0.0228)										OREG0017364	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0.227273	6.554887	8.077368	5	17	GG		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(397;1.11e-10)	Missense_Mutation	SNP	34322597	34322597	2417	6	G	T	T	44	44	C6orf1	T	3	3
KBTBD2	25948	broad.mit.edu	36	7	32875663	32875663	+	Missense_Mutation	SNP	C	T	T			TCGA-06-2569-01	TCGA-06-2569-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr7:32875663C>T	uc003tdb.1	-	c.1691G>A	c.(1690-1692)CGG>CAG	p.R564Q		NM_015483	NP_056298	Q8IY47	KBTB2_HUMAN	kelch repeat and BTB (POZ) domain containing 2	564	Kelch 5.										0														0.160804	63.106985	84.871338	32	167	CC		KEEP	---	---	---	---	capture	GBM - Glioblastoma multiforme(11;0.0499)		Missense_Mutation	SNP	32875663	32875663	8298	7	C	T	T	23	23	KBTBD2	T	1	1
SEPT7	989	broad.mit.edu	36	7	35896887	35896887	+	Silent	SNP	T	C	C			TCGA-06-2569-01	TCGA-06-2569-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr7:35896887T>C	uc010kxc.1	+	c.957T>C	c.(955-957)TAT>TAC	p.Y319Y	SEPT7_uc010kxb.1_Silent_p.Y318Y|SEPT7_uc003tey.1_Silent_p.Y167Y	NM_001788	NP_001779	Q16181	SEPT7_HUMAN	cell division cycle 10 isoform 1	319					cilium morphogenesis|cytokinesis|mitosis|protein heterooligomerization|regulation of embryonic cell shape	cilium axoneme|cleavage furrow|condensed chromosome kinetochore|midbody|nucleus|septin complex|spindle|stress fiber	GTP binding|protein binding|structural molecule activity				0														0.104167	6.444142	13.921858	5	43	TT		KEEP	---	---	---	---	capture			Silent	SNP	35896887	35896887	14555	7	T	C	C	49	49	SEPT7	C	4	4
ELN	2006	broad.mit.edu	36	7	73112427	73112427	+	Missense_Mutation	SNP	A	G	G			TCGA-06-2569-01	TCGA-06-2569-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr7:73112427A>G	uc003tzw.1	+	c.1616A>G	c.(1615-1617)AAG>AGG	p.K539R	ELN_uc003tzn.1_Missense_Mutation_p.K533R|ELN_uc003tzz.1_Missense_Mutation_p.K452R|ELN_uc003tzo.1_Intron|ELN_uc003tzp.1_Missense_Mutation_p.K444R|ELN_uc003tzq.1_Missense_Mutation_p.K397R|ELN_uc003tzr.1_Intron|ELN_uc003tzs.1_Missense_Mutation_p.K514R|ELN_uc003tzt.1_Missense_Mutation_p.K538R|ELN_uc003tzu.1_Missense_Mutation_p.K519R|ELN_uc003tzv.1_Missense_Mutation_p.K504R|ELN_uc010lbk.1_Non-coding_Transcript|ELN_uc003tzx.1_Missense_Mutation_p.K523R|ELN_uc003tzy.1_Missense_Mutation_p.K509R	NM_000501	NP_001075224	P15502	ELN_HUMAN	elastin isoform a precursor	562	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			ovary(3)|pancreas(2)	5		Lung NSC(55;0.159)			Rofecoxib(DB00533)					434				0.894737	372.419804	390.0764	102	12	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	73112427	73112427	5263	7	A	G	G	3	3	ELN	G	4	4
ZFHX4	79776	broad.mit.edu	36	8	77928994	77928994	+	Missense_Mutation	SNP	G	C	C			TCGA-06-2569-01	TCGA-06-2569-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr8:77928994G>C	uc003yav.1	+	c.7147G>C	c.(7147-7149)GCC>CCC	p.A2383P	ZFHX4_uc003yau.1_Missense_Mutation_p.A2428P|ZFHX4_uc003yaw.1_Missense_Mutation_p.A2383P	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2383	Pro-rich.				regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulator activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15														0.3	7.220198	7.578213	3	7	GG		KEEP	---	---	---	---	capture	BRCA - Breast invasive adenocarcinoma(89;0.0895)		Missense_Mutation	SNP	77928994	77928994	18223	8	G	C	C	34	34	ZFHX4	C	3	3
ANAPC2	29882	broad.mit.edu	36	9	139194556	139194556	+	Silent	SNP	C	A	A			TCGA-06-2569-01	TCGA-06-2569-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr9:139194556C>A	uc004clr.1	-	c.1788G>T	c.(1786-1788)CTG>CTT	p.L596L	ANAPC2_uc004clq.1_Silent_p.L452L	NM_013366	NP_037498	Q9UJX6	ANC2_HUMAN	anaphase-promoting complex subunit 2	596					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of cyclin-dependent protein kinase activity	anaphase-promoting complex|cytosol|nucleoplasm	ubiquitin protein ligase binding|ubiquitin-protein ligase activity			ovary(1)	1	all_cancers(76;0.0926)													0.296552	120.056745	125.432649	43	102	CC		KEEP	---	---	---	---	capture	STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.000858)	Silent	SNP	139194556	139194556	606	9	C	A	A	17	17	ANAPC2	A	3	3
WNK2	65268	broad.mit.edu	36	9	95070002	95070002	+	Missense_Mutation	SNP	G	T	T			TCGA-06-2569-01	TCGA-06-2569-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr9:95070002G>T	uc004ati.1	+	c.3850G>T	c.(3850-3852)GGC>TGC	p.G1284C	WNK2_uc004atj.1_Missense_Mutation_p.G1284C|WNK2_uc004atk.2_Missense_Mutation_p.G921C	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1284					intracellular protein kinase cascade|protein phosphorylation		ATP binding|protein binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|stomach(1)|large_intestine(1)|central_nervous_system(1)	7										1420				0.296296	22.427646	23.407855	8	19	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	95070002	95070002	17952	9	G	T	T	39	39	WNK2	T	3	3
PCDH19	57526	broad.mit.edu	36	X	99549947	99549947	+	Missense_Mutation	SNP	G	A	A			TCGA-06-2569-01	TCGA-06-2569-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chrX:99549947G>A	uc010nmz.1	-	c.305C>T	c.(304-306)TCG>TTG	p.S102L	PCDH19_uc004efw.2_Missense_Mutation_p.S102L|PCDH19_uc004efx.2_Missense_Mutation_p.S102L	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	102	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7														0.337662	147.951241	151.541195	52	102	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	99549947	99549947	11934	23	G	A	A	37	37	PCDH19	A	1	1
NF1	4763	broad.mit.edu	36	17	26677168	26677169	+	Frame_Shift_Ins	INS	-	A	A			TCGA-06-2569-01	TCGA-06-2569-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:26677168_26677169insA	uc002hgg.1	+	c.5040_5041insA	c.(5038-5043)TATAACfs	p.Y1680fs	NF1_uc002hgh.1_Frame_Shift_Ins_p.Y1659fs|NF1_uc002hgi.1_Frame_Shift_Ins_p.Y692fs|NF1_uc010cso.1_5'UTR	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1680_1681	CRAL-TRIO.				actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(1)		soft_tissue(155)|central_nervous_system(56)|large_intestine(27)|lung(19)|haematopoietic_and_lymphoid_tissue(13)|ovary(12)|autonomic_ganglia(7)|skin(3)|stomach(2)|breast(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	300		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)						847	TCGA GBM(6;<1E-8)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			0.85			161	29				---	---	---	---	capture_indel			Frame_Shift_Ins	INS	26677168	26677169	10756	17	-	A	A	49	49	NF1	A	5	5
TP53	7157	broad.mit.edu	36	17	7519181	7519192	+	In_Frame_Del	DEL	GCGGACGCGGGT	-	-			TCGA-06-2569-01	TCGA-06-2569-01										Phase_I	Unspecified				Illumina GAIIx	g.chr17:7519181_7519192delGCGGACGCGGGT	uc002gim.2	-	c.463_474delACCCGCGTCCGC	c.(463-474)ACCCGCGTCCGCdel	p.TRVR155del	TP53_uc002gig.1_In_Frame_Del_p.TRVR155del|TP53_uc002gih.1_In_Frame_Del_p.TRVR155del|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_In_Frame_Del_p.TRVR23del|TP53_uc010cng.1_In_Frame_Del_p.TRVR23del|TP53_uc002gii.1_In_Frame_Del_p.TRVR23del|TP53_uc010cnh.1_In_Frame_Del_p.TRVR155del|TP53_uc010cni.1_In_Frame_Del_p.TRVR155del|TP53_uc002gij.2_In_Frame_Del_p.TRVR155del|TP53_uc010cnj.1_Non-coding_Transcript|TP53_uc002gin.2_In_Frame_Del_p.TRVR62del|TP53_uc002gio.2_In_Frame_Del_p.TRVR23del	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	155_158	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of gene-specific transcription from RNA polymerase II promoter|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of gene-specific transcription from RNA polymerase II promoter|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	chromatin|cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|promoter binding|promoter binding|protease binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin protein ligase binding|zinc ion binding	p.V157F(138)|p.R158H(55)|p.R158L(51)|p.R156P(24)|p.T155N(19)|p.R158C(17)|p.T155P(14)|p.T155I(10)|p.R156H(10)|p.R158G(10)|p.R158P(9)|p.V157I(9)|p.V157D(8)|p.R156fs*14(8)|p.T155A(7)|p.V157G(7)|p.V157L(6)|p.R158R(6)|p.0?(6)|p.V157V(5)|p.T155T(5)|p.R158fs*12(5)|p.P152fs*14(4)|p.R158_A159insX(4)|p.V157fs*13(3)|p.R156R(3)|p.R156S(3)|p.R156fs*25(3)|p.R156L(3)|p.R156G(3)|p.T155S(2)|p.R158_A159delRA(2)|p.R156_I162delRVRAMAI(2)|p.T155fs*23(2)|p.V157del(2)|p.V157fs*9(2)|p.P153fs*22(2)|p.G154fs*14(2)|p.R158fs*11(2)|p.R156C(2)|p.V157fs*22(2)|p.V157fs*24(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.R158F(1)|p.P151_V173del23(1)|p.R158fs*24(1)|p.A159fs*11(1)|p.D148fs*23(1)|p.V157A(1)|p.A159fs*21(1)|p.R156_R158delRVR(1)|p.R156fs*18(1)|p.T155fs*25(1)|p.D148_T155delDSTPPPGT(1)|p.G154_R156delGTR(1)|p.V157_M160delVRAM(1)|p.R156fs*12(1)|p.V157_R158delVR(1)|p.S149fs*72(1)|p.R158_A159insXX(1)|p.T155_A161delTRVRAMA(1)|p.G154fs*22(1)|p.R156del(1)|p.T155fs*15(1)|p.T155_R156delTR(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.V157fs*25(1)|p.V157fs*23(1)|p.V157fs*21(1)|p.R158fs*8(1)|p.T155fs*26(1)		large_intestine(4614)|breast(2344)|upper_aerodigestive_tract(2150)|lung(1958)|ovary(1559)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1212)|stomach(1127)|urinary_tract(1113)|central_nervous_system(1072)|liver(805)|skin(693)|pancreas(370)|biliary_tract(247)|soft_tissue(209)|prostate(192)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(41)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	21904		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		Pancreas(47;798 1329 9957 10801)		111	p.V157F(NCIH1781-Tumor)|p.T155N(NCIH524-Tumor)|p.T155P(DMS153-Tumor)|p.R158H(MOLT16-Tumor)|p.R158L(NCIH747-Tumor)|p.R156P(HTK-Tumor)|p.V157F(DMS454-Tumor)|p.V157F(HS578T-Tumor)|p.R158P(NCIH2110-Tumor)|p.V157F(NCIH2196-Tumor)|p.R158L(NCIH661-Tumor)|p.R158G(SNU1105-Tumor)|p.R156P(HOS-Tumor)|p.R158L(NCIH441-Tumor)|p.V157F(VMRCLCP-Tumor)|p.P152fs(RH41-Tumor)|p.V157F(NCIH2066-Tumor)|p.V157F(NCIH2087-Tumor)|p.R158G(NCIH2170-Tumor)|p.R158H(ST486-Tumor)|p.V157F(CORL88-Tumor)	690	TCGA GBM(1;<1E-8)|TSP Lung(2;<1E-8)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0.75			57	19				---	---	---	---	capture_indel			In_Frame_Del	DEL	7519181	7519192	16923	17	GCGGACGCGGGT	-	-	38	38	TP53	-	5	5
HOXD8	3234	broad.mit.edu	36	2	176704546	176704547	+	Frame_Shift_Del	DEL	AA	-	-			TCGA-06-2569-01	TCGA-06-2569-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:176704546_176704547delAA	uc002uko.1	+	c.833_834delAA	c.(832-834)CAAfs	p.Q278fs	HOXD8_uc002ukn.1_Frame_Shift_Del_p.Q94fs|HOXD8_uc002ukp.2_Frame_Shift_Del_p.Q277fs	NM_019558	NP_062458	P13378	HXD8_HUMAN	homeobox D8	278					anterior/posterior axis specification, embryo	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.195)	Colorectal(32;0.0224)|READ - Rectum adenocarcinoma(9;0.0556)										0.35			26	48				---	---	---	---	capture_indel			Frame_Shift_Del	DEL	176704546	176704547	7617	2	AA	-	-	5	5	HOXD8	-	5	5
