Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	i_TCGAscape_Amplification_Peaks	i_TCGAscape_Deletion_Peaks	DrugBank	i_ACHILLES_Top_Genes	i_CCLE_ONCOMAP_overlapping_mutations	i_CCLE_ONCOMAP_total_mutations_in_gene	i_CCLE_SEQ_overlapping_mutations	i_CCLE_SEQ_total_mutations_in_gene	MUTSIG_Significant_Genes	OREGANNO_ID	OREGANNO_Values	i_tumor_f	i_init_t_lod	i_t_lod_fstar	i_t_alt_count	i_t_ref_count	i_normal_best_gt	i_failure_reasons	i_judgement	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	dataset	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	type	classification	start	end	gene	chr	ref_allele	tum_allele1	tum_allele2	context_orig	context65	gene_name	newbase	categ	categ_ignoring_null_categ
WT1	7490	broad.mit.edu	36	11	32406690	32406690	+	Missense_Mutation	SNP	G	A	A			TCGA-12-0615-01	TCGA-12-0615-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr11:32406690G>A	uc001mtn.1	-	c.698C>T	c.(697-699)TCG>TTG	p.S233L	WT1_uc001mtl.1_Missense_Mutation_p.S21L|WT1_uc001mtm.1_Missense_Mutation_p.S21L|WT1_uc001mto.1_Missense_Mutation_p.S233L|WT1_uc001mtp.1_Missense_Mutation_p.S233L|WT1_uc001mtq.1_Missense_Mutation_p.S233L|WT1_uc009yjs.1_Non-coding_Transcript	NM_024426	NP_077744	P19544	WT1_HUMAN	Wilms tumor 1 isoform D	165					adrenal gland development|branching involved in ureteric bud morphogenesis|glomerular basement membrane development|glomerular visceral epithelial cell differentiation|induction of apoptosis|male gonad development|metanephric S-shaped body morphogenesis|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of gene-specific transcription|negative regulation of transcription from RNA polymerase II promoter|negative regulation of translation|positive regulation of gene-specific transcription|sex determination|visceral serous pericardium development	cytoplasm|nuclear speck|nucleoplasm	C2H2 zinc finger domain binding|promoter binding|RNA binding|sequence-specific DNA binding transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription repressor activity|zinc ion binding		EWSR1/WT1(231)	haematopoietic_and_lymphoid_tissue(302)|soft_tissue(231)|kidney(132)|pleura(2)|peritoneum(1)|lung(1)	669	Breast(20;0.247)									684				0.529412	112.279611	112.329426	36	32	GG		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(30;0.128)		Missense_Mutation	SNP	32406690	32406690	17982	11	G	A	A	37	37	WT1	A	1	1
SLC22A25	387601	broad.mit.edu	36	11	62704753	62704753	+	Missense_Mutation	SNP	C	T	T			TCGA-12-0615-01	TCGA-12-0615-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr11:62704753C>T	uc001nwr.1	-	c.1025G>A	c.(1024-1026)CGC>CAC	p.R342H	SLC22A25_uc009yoq.1_Non-coding_Transcript|SLC22A25_uc001nws.1_Non-coding_Transcript|SLC22A25_uc001nwt.1_Missense_Mutation_p.R342H	NM_199352	NP_955384	Q6T423	S22AP_HUMAN	putative UST1-like organic anion transporter	342	Cytoplasmic (Potential).				transmembrane transport	integral to membrane				ovary(3)	3														0.454054	257.983399	258.322781	84	101	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	62704753	62704753	14951	11	C	T	T	27	27	SLC22A25	T	1	1
DCHS1	8642	broad.mit.edu	36	11	6611747	6611747	+	Missense_Mutation	SNP	C	G	G			TCGA-12-0615-01	TCGA-12-0615-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr11:6611747C>G	uc001mem.1	-	c.2067G>C	c.(2065-2067)GAG>GAC	p.E689D		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	689	Cadherin 7.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)												0.342657	153.450904	156.569475	49	94	CC		KEEP	---	---	---	---	capture		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)	Missense_Mutation	SNP	6611747	6611747	4458	11	C	G	G	20	20	DCHS1	G	3	3
ARAP1	116985	broad.mit.edu	36	11	72101181	72101181	+	Silent	SNP	G	A	A			TCGA-12-0615-01	TCGA-12-0615-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr11:72101181G>A	uc001ost.1	-	c.828C>T	c.(826-828)GAC>GAT	p.D276D	ARAP1_uc001osr.1_Silent_p.D36D|ARAP1_uc001oss.1_Silent_p.D31D|ARAP1_uc009yth.1_Silent_p.D31D|ARAP1_uc001osu.1_Silent_p.D276D|ARAP1_uc001osv.1_Silent_p.D276D	NM_001040118	NP_631920	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	276					actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding				0						Ovarian(102;1198 1520 13195 17913 37529)								0.503049	504.668135	504.671003	165	163	GG		KEEP	---	---	---	---	capture			Silent	SNP	72101181	72101181	849	11	G	A	A	40	40	ARAP1	A	1	1
RIC8B	55188	broad.mit.edu	36	12	105732709	105732709	+	Missense_Mutation	SNP	T	G	G			TCGA-12-0615-01	TCGA-12-0615-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr12:105732709T>G	uc001tlw.2	+	c.238T>G	c.(238-240)TTA>GTA	p.L80V	RIC8B_uc001tlx.1_Missense_Mutation_p.L80V|RIC8B_uc001tly.1_Missense_Mutation_p.L40V|RIC8B_uc001tlz.1_Non-coding_Transcript	NM_018157	NP_060627	Q9NVN3	RIC8B_HUMAN	resistance to inhibitors of cholinesterase 8	80					regulation of G-protein coupled receptor protein signaling pathway	cell cortex|cytosol|plasma membrane	G-protein alpha-subunit binding|guanyl-nucleotide exchange factor activity			ovary(1)	1														0.445161	240.283073	240.684067	69	86	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	105732709	105732709	13831	12	T	G	G	64	64	RIC8B	G	4	4
MLXIP	22877	broad.mit.edu	36	12	121179690	121179690	+	Missense_Mutation	SNP	G	A	A			TCGA-12-0615-01	TCGA-12-0615-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr12:121179690G>A	uc001ubq.1	+	c.659G>A	c.(658-660)CGG>CAG	p.R220Q	MLXIP_uc001ubr.2_5'UTR|MLXIP_uc001ubs.1_5'Flank	NM_014938	NP_055753	Q9HAP2	MLXIP_HUMAN	MLX interacting protein	220	Required for cytoplasmic localization.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial outer membrane|nucleus	DNA binding|transcription regulator activity			ovary(2)	2	all_neural(191;0.0837)|Medulloblastoma(191;0.163)	Lung NSC(355;0.0659)				Esophageal Squamous(105;787 1493 16200 18566 52466)								0.28125	26.562282	27.9378	9	23	GG		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(86;0.000599)|Epithelial(86;0.00102)|BRCA - Breast invasive adenocarcinoma(302;0.233)	Missense_Mutation	SNP	121179690	121179690	10026	12	G	A	A	39	39	MLXIP	A	1	1
TMEM19	55266	broad.mit.edu	36	12	70378994	70378994	+	Missense_Mutation	SNP	G	A	A			TCGA-12-0615-01	TCGA-12-0615-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr12:70378994G>A	uc001sws.1	+	c.685G>A	c.(685-687)GGT>AGT	p.G229S	TMEM19_uc001swr.1_Missense_Mutation_p.G215S|TMEM19_uc009zru.1_Non-coding_Transcript	NM_018279	NP_060749	Q96HH6	TMM19_HUMAN	transmembrane protein 19	229	Helical; (Potential).					integral to membrane					0		Breast(359;0.0889)												0.385593	264.297815	267.027626	91	145	GG		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(134;0.044)	Missense_Mutation	SNP	70378994	70378994	16647	12	G	A	A	47	47	TMEM19	A	2	2
SOCS2	8835	broad.mit.edu	36	12	92492792	92492792	+	Silent	SNP	C	T	T			TCGA-12-0615-01	TCGA-12-0615-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr12:92492792C>T	uc001tcw.1	+	c.303C>T	c.(301-303)GAC>GAT	p.D101D	SOCS2_uc001tcx.1_Silent_p.D101D|SOCS2_uc009zsu.1_3'UTR|SOCS2_uc001tcy.1_Silent_p.D101D|SOCS2_uc001tcz.2_3'UTR	NM_003877	NP_003868	O14508	SOCS2_HUMAN	suppressor of cytokine signaling-2	101	SH2.				anti-apoptosis|growth hormone receptor signaling pathway|negative regulation of signal transduction|regulation of cell growth|response to estradiol stimulus	cytoplasm	growth hormone receptor binding|insulin-like growth factor receptor binding|JAK pathway signal transduction adaptor activity|prolactin receptor binding|SH3/SH2 adaptor activity				0														0.396825	147.548628	148.713655	50	76	CC		KEEP	---	---	---	---	capture			Silent	SNP	92492792	92492792	15414	12	C	T	T	19	19	SOCS2	T	1	1
GALK2	2585	broad.mit.edu	36	15	47249819	47249819	+	Missense_Mutation	SNP	C	A	A			TCGA-12-0615-01	TCGA-12-0615-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr15:47249819C>A	uc001zxj.1	+	c.8C>A	c.(7-9)ACA>AAA	p.T3K	GALK2_uc001zxi.1_Intron|GALK2_uc001zxk.1_Non-coding_Transcript	NM_002044	NP_002035	Q01415	GALK2_HUMAN	galactokinase 2 isoform 1	3					galactose metabolic process	cytoplasm	ATP binding|galactokinase activity|N-acetylgalactosamine kinase activity			breast(1)	1		all_lung(180;0.000325)												0.4	7.470856	7.565095	4	6	CC		KEEP	---	---	---	---	capture		all cancers(107;3.71e-08)|GBM - Glioblastoma multiforme(94;7e-05)	Missense_Mutation	SNP	47249819	47249819	6468	15	C	A	A	17	17	GALK2	A	3	3
SSTR5	6755	broad.mit.edu	36	16	1069321	1069321	+	Missense_Mutation	SNP	G	A	A			TCGA-12-0615-01	TCGA-12-0615-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr16:1069321G>A	uc002ckq.1	+	c.452G>A	c.(451-453)CGC>CAC	p.R151H		NM_001053	NP_001044	P35346	SSR5_HUMAN	somatostatin receptor 5	151	Cytoplasmic (Potential).				negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity				0		Hepatocellular(780;0.00369)			Octreotide(DB00104)									0.5	26.921966	26.921966	11	11	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	1069321	1069321	15717	16	G	A	A	38	38	SSTR5	A	1	1
NUBP1	4682	broad.mit.edu	36	16	10745385	10745385	+	Missense_Mutation	SNP	G	A	A			TCGA-12-0615-01	TCGA-12-0615-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr16:10745385G>A	uc002daa.1	+	c.86G>A	c.(85-87)CGG>CAG	p.R29Q	NUBP1_uc010bum.1_5'UTR|NUBP1_uc002dab.1_Missense_Mutation_p.R29Q	NM_002484	NP_002475	P53384	NUBP1_HUMAN	nucleotide binding protein 1	29					cell growth|cellular iron ion homeostasis|iron-sulfur cluster assembly	cytosol	4 iron, 4 sulfur cluster binding|ATP binding|metal ion binding|nucleoside-triphosphatase activity|protein binding			ovary(1)	1														0.545455	39.904285	39.944291	12	10	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	10745385	10745385	11120	16	G	A	A	39	39	NUBP1	A	1	1
FBXW10	10517	broad.mit.edu	36	17	18592042	18592042	+	Missense_Mutation	SNP	C	T	T			TCGA-12-0615-01	TCGA-12-0615-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr17:18592042C>T	uc002gul.1	+	c.569C>T	c.(568-570)GCG>GTG	p.A190V	FBXW10_uc002guk.2_Missense_Mutation_p.A190V|FBXW10_uc010cqh.1_Missense_Mutation_p.A190V|FBXW10_uc002guj.1_Missense_Mutation_p.A190V	NM_031456	NP_113644	Q5XX13	FBW10_HUMAN	F-box and WD-40 domain protein 10	190	WD 1.									ovary(1)	1														0.3	71.390308	74.606589	27	63	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	18592042	18592042	6000	17	C	T	T	27	27	FBXW10	T	1	1
PIPOX	51268	broad.mit.edu	36	17	24404693	24404693	+	Missense_Mutation	SNP	G	C	C			TCGA-12-0615-01	TCGA-12-0615-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr17:24404693G>C	uc002hdr.1	+	c.614G>C	c.(613-615)TGG>TCG	p.W205S		NM_016518	NP_057602	Q9P0Z9	SOX_HUMAN	L-pipecolic acid oxidase	205					oxidation-reduction process|tetrahydrofolate metabolic process	peroxisome	L-pipecolate oxidase activity|sarcosine oxidase activity				0	Lung NSC(42;0.015)				Glycine(DB00145)									0.381643	227.737738	230.293201	79	128	GG		KEEP	---	---	---	---	capture	Epithelial(11;9.87e-06)|BRCA - Breast invasive adenocarcinoma(11;3.92e-05)|all cancers(11;5.59e-05)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)		Missense_Mutation	SNP	24404693	24404693	12367	17	G	C	C	47	47	PIPOX	C	3	3
C17orf74	201243	broad.mit.edu	36	17	7271359	7271359	+	Missense_Mutation	SNP	C	T	T			TCGA-12-0615-01	TCGA-12-0615-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr17:7271359C>T	uc002ggw.1	+	c.1325C>T	c.(1324-1326)CCG>CTG	p.P442L		NM_175734	NP_783861	Q0P670	CQ074_HUMAN	hypothetical protein LOC201243	442						integral to membrane					0		Prostate(122;0.157)												0.427184	133.884894	134.360835	44	59	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	7271359	7271359	1937	17	C	T	T	23	23	C17orf74	T	1	1
LAMA1	284217	broad.mit.edu	36	18	7000303	7000303	+	Missense_Mutation	SNP	G	C	C			TCGA-12-0615-01	TCGA-12-0615-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr18:7000303G>C	uc002knm.1	-	c.3769C>G	c.(3769-3771)CAA>GAA	p.Q1257E		NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	1257	Laminin IV type A 2.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|breast(2)|pancreas(2)|central_nervous_system(1)	17		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)					1597				0.456647	280.408895	280.691974	79	94	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	7000303	7000303	8928	18	G	C	C	45	45	LAMA1	C	3	3
MIDN	90007	broad.mit.edu	36	19	1201466	1201466	+	Silent	SNP	C	G	G			TCGA-12-0615-01	TCGA-12-0615-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr19:1201466C>G	uc002lrp.1	+	c.171C>G	c.(169-171)CGC>CGG	p.R57R		NM_177401	NP_796375	Q504T8	MIDN_HUMAN	midnolin	57	Ubiquitin-like.					nucleolus					0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)												0.608696	42.917217	43.152663	14	9	CC		KEEP	---	---	---	---	capture		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Silent	SNP	1201466	1201466	9969	19	C	G	G	25	25	MIDN	G	3	3
CELSR2	1952	broad.mit.edu	36	1	109602996	109602996	+	Missense_Mutation	SNP	G	A	A			TCGA-12-0615-01	TCGA-12-0615-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:109602996G>A	uc001dxa.2	+	c.3730G>A	c.(3730-3732)GTG>ATG	p.V1244M		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	1244	EGF-like 1; calcium-binding.|Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of gene-specific transcription|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(3)	3		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)				NSCLC(158;1285 2011 34800 34852 42084)								0.388889	20.523056	20.716966	7	11	GG		KEEP	---	---	---	---	capture		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)	Missense_Mutation	SNP	109602996	109602996	3355	1	G	A	A	40	40	CELSR2	A	1	1
MOV10	4343	broad.mit.edu	36	1	113040775	113040775	+	Missense_Mutation	SNP	G	A	A			TCGA-12-0615-01	TCGA-12-0615-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:113040775G>A	uc001eck.1	+	c.1982G>A	c.(1981-1983)GGG>GAG	p.G661E	MOV10_uc001ecl.1_Intron|MOV10_uc001ecm.1_Missense_Mutation_p.G601E|MOV10_uc001ecn.1_Missense_Mutation_p.G661E|MOV10_uc001eco.1_Missense_Mutation_p.G661E	NM_020963	NP_066014	Q9HCE1	MOV10_HUMAN	Mov10, Moloney leukemia virus 10, homolog	661					mRNA cleavage involved in gene silencing by miRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body	ATP binding|helicase activity|protein binding|RNA binding			ovary(4)	4	Lung SC(450;0.246)	all_cancers(81;3.31e-11)|all_epithelial(167;5.69e-10)|all_lung(203;3.73e-05)|Breast(1374;0.000525)|Lung NSC(69;0.000954)|Ovarian(761;0.0367)|Lung SC(238;0.114)												0.692308	62.557628	63.413913	18	8	GG		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(397;3.99e-67)|all cancers(265;1e-62)|Epithelial(280;4.78e-61)|Lung(183;0.0234)|Colorectal(144;0.0686)|READ - Rectum adenocarcinoma(129;0.0929)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|BRCA - Breast invasive adenocarcinoma(282;0.24)	Missense_Mutation	SNP	113040775	113040775	10110	1	G	A	A	43	43	MOV10	A	2	2
TCHHL1	126637	broad.mit.edu	36	1	150327172	150327172	+	Silent	SNP	G	A	A			TCGA-12-0615-01	TCGA-12-0615-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:150327172G>A	uc001ezo.1	-	c.72C>T	c.(70-72)AAC>AAT	p.N24N		NM_001008536	NP_001008536	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	24							calcium ion binding			ovary(1)	1	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)													0.596591	670.990171	673.85784	210	142	GG		KEEP	---	---	---	---	capture	LUSC - Lung squamous cell carcinoma(543;0.246)		Silent	SNP	150327172	150327172	16227	1	G	A	A	40	40	TCHHL1	A	1	1
FLG	2312	broad.mit.edu	36	1	150545329	150545329	+	Missense_Mutation	SNP	C	T	T			TCGA-12-0615-01	TCGA-12-0615-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:150545329C>T	uc001ezu.1	-	c.8657G>A	c.(8656-8658)CGC>CAC	p.R2886H		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2886	Ser-rich.|Filaggrin 17.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)	9	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)													0.133484	79.369498	136.964788	59	383	CC		KEEP	---	---	---	---	capture	LUSC - Lung squamous cell carcinoma(543;0.206)		Missense_Mutation	SNP	150545329	150545329	6160	1	C	T	T	27	27	FLG	T	1	1
KPRP	448834	broad.mit.edu	36	1	151000289	151000289	+	Missense_Mutation	SNP	G	T	T			TCGA-12-0615-01	TCGA-12-0615-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:151000289G>T	uc001fal.1	+	c.1601G>T	c.(1600-1602)AGT>ATT	p.S534I	KPRP_uc009wnn.1_Missense_Mutation_p.S534I	NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	534						cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)													0.320755	189.606711	195.667574	68	144	GG		KEEP	---	---	---	---	capture	LUSC - Lung squamous cell carcinoma(543;0.206)		Missense_Mutation	SNP	151000289	151000289	8751	1	G	T	T	36	36	KPRP	T	3	3
DDR2	4921	broad.mit.edu	36	1	161016608	161016608	+	Missense_Mutation	SNP	G	A	A			TCGA-12-0615-01	TCGA-12-0615-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:161016608G>A	uc001gcf.1	+	c.2516G>A	c.(2515-2517)CGT>CAT	p.R839H	DDR2_uc001gcg.1_Missense_Mutation_p.R839H	NM_001014796	NP_006173	Q16832	DDR2_HUMAN	discoidin domain receptor family, member 2	839	Cytoplasmic (Potential).|Protein kinase.				cell adhesion|protein phosphorylation	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(2)|central_nervous_system(2)|ovary(1)|kidney(1)	6	all_hematologic(112;0.115)					NSCLC(161;314 2006 8283 19651 23192)				497				0.599515	775.987237	779.555047	247	165	GG		KEEP	---	---	---	---	capture	BRCA - Breast invasive adenocarcinoma(70;0.113)		Missense_Mutation	SNP	161016608	161016608	4508	1	G	A	A	40	40	DDR2	A	1	1
ILDR2	387597	broad.mit.edu	36	1	165157093	165157093	+	Silent	SNP	G	C	C			TCGA-12-0615-01	TCGA-12-0615-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:165157093G>C	uc001gdx.1	-	c.1359C>G	c.(1357-1359)GGC>GGG	p.G453G		NM_199351	NP_955383	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor	453	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1														0.454545	8.249359	8.268974	5	6	GG		KEEP	---	---	---	---	capture			Silent	SNP	165157093	165157093	8011	1	G	C	C	38	38	ILDR2	C	3	3
KIFAP3	22920	broad.mit.edu	36	1	168274090	168274090	+	Missense_Mutation	SNP	C	T	T			TCGA-12-0615-01	TCGA-12-0615-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:168274090C>T	uc001ggv.1	-	c.482G>A	c.(481-483)CGA>CAA	p.R161Q	KIFAP3_uc001ggw.1_Missense_Mutation_p.R117Q	NM_014970	NP_055785	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	161					blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding				0	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)													0.372414	163.912898	165.986389	54	91	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	168274090	168274090	8622	1	C	T	T	31	31	KIFAP3	T	1	1
FAM5B	57795	broad.mit.edu	36	1	175465895	175465895	+	Missense_Mutation	SNP	G	A	A			TCGA-12-0615-01	TCGA-12-0615-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:175465895G>A	uc001glf.1	+	c.260G>A	c.(259-261)AGG>AAG	p.R87K		NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	87						extracellular region				ovary(2)	2														0.321951	189.258104	195.040384	66	139	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	175465895	175465895	5816	1	G	A	A	35	35	FAM5B	A	2	2
IL28RA	163702	broad.mit.edu	36	1	24379922	24379922	+	Missense_Mutation	SNP	C	T	T			TCGA-12-0615-01	TCGA-12-0615-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:24379922C>T	uc001bis.1	-	c.68G>A	c.(67-69)CGT>CAT	p.R23H	IL28RA_uc001bir.1_Missense_Mutation_p.R23H|IL28RA_uc001bit.1_Missense_Mutation_p.R23H|IL28RA_uc001biu.1_Intron|IL28RA_uc001biv.2_Missense_Mutation_p.R23H	NM_170743	NP_734464	Q8IU57	I28RA_HUMAN	interleukin 28 receptor, alpha isoform 1	23	Extracellular (Potential).|Fibronectin type-III.				cytokine-mediated signaling pathway|negative regulation of cell proliferation|regulation of defense response to virus by host	interleukin-28 receptor complex	protein binding|receptor activity				0		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00117)|all_lung(284;0.00151)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)												0.4125	99.966049	100.499325	33	47	CC		KEEP	---	---	---	---	capture		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;3.21e-24)|Colorectal(126;6.61e-08)|COAD - Colon adenocarcinoma(152;3.56e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00918)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.185)	Missense_Mutation	SNP	24379922	24379922	7985	1	C	T	T	19	19	IL28RA	T	1	1
C1orf177	163747	broad.mit.edu	36	1	55046185	55046185	+	Missense_Mutation	SNP	A	T	T			TCGA-12-0615-01	TCGA-12-0615-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr1:55046185A>T	uc001cyb.2	+	c.393A>T	c.(391-393)AAA>AAT	p.K131N	C1orf177_uc001cya.2_Missense_Mutation_p.K131N	NM_001110533	NP_001104003	Q3ZCV2	CA177_HUMAN	hypothetical protein LOC163747 isoform 2	131											0														0.480315	373.408606	373.495456	122	132	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	55046185	55046185	2084	1	A	T	T	3	3	C1orf177	T	4	4
TASP1	55617	broad.mit.edu	36	20	13457135	13457135	+	Missense_Mutation	SNP	G	C	C			TCGA-12-0615-01	TCGA-12-0615-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr20:13457135G>C	uc002woi.1	-	c.819C>G	c.(817-819)TGC>TGG	p.C273W	TASP1_uc002woh.1_Missense_Mutation_p.C250W	NM_017714	NP_060184	Q9H6P5	TASP1_HUMAN	taspase 1 precursor	273					asparagine catabolic process via L-aspartate|positive regulation of transcription, DNA-dependent|protein maturation		threonine-type endopeptidase activity				0														0.333333	7.847686	8.227904	5	10	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	13457135	13457135	16111	20	G	C	C	34	34	TASP1	C	3	3
PCSK2	5126	broad.mit.edu	36	20	17337925	17337925	+	Silent	SNP	C	T	T			TCGA-12-0615-01	TCGA-12-0615-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr20:17337925C>T	uc002wpm.1	+	c.561C>T	c.(559-561)TAC>TAT	p.Y187Y	PCSK2_uc002wpl.1_Silent_p.Y168Y	NM_002594	NP_002585	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	187	Catalytic.				enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			ovary(3)|central_nervous_system(2)|large_intestine(1)|pancreas(1)	7					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)									0.376667	331.718191	335.716612	113	187	CC		KEEP	---	---	---	---	capture			Silent	SNP	17337925	17337925	12022	20	C	T	T	19	19	PCSK2	T	1	1
PROKR2	128674	broad.mit.edu	36	20	5230952	5230952	+	Missense_Mutation	SNP	C	T	T			TCGA-12-0615-01	TCGA-12-0615-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr20:5230952C>T	uc002wlx.2	-	c.889G>A	c.(889-891)GTT>ATT	p.V297I	PROKR2_uc010gbj.1_Missense_Mutation_p.V297I|PROKR2_uc010gbk.1_Missense_Mutation_p.V297I	NM_144773	NP_658986	Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	297	Extracellular (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5														0.413534	169.20584	170.072832	55	78	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	5230952	5230952	12996	20	C	T	T	19	19	PROKR2	T	1	1
OPRL1	4987	broad.mit.edu	36	20	62199792	62199792	+	Missense_Mutation	SNP	G	A	A			TCGA-12-0615-01	TCGA-12-0615-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr20:62199792G>A	uc002yic.1	+	c.427G>A	c.(427-429)GCC>ACC	p.A143T	OPRL1_uc002yid.1_Missense_Mutation_p.A143T|OPRL1_uc002yif.2_Missense_Mutation_p.A138T	NM_182647	NP_872588	P41146	OPRX_HUMAN	opiate receptor-like 1	143	Helical; Name=3; (Potential).				elevation of cytosolic calcium ion concentration|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception	integral to plasma membrane	protein binding|X-opioid receptor activity			central_nervous_system(1)	1	all_cancers(38;4.74e-11)|all_epithelial(29;1.33e-12)|Lung NSC(23;3.27e-09)|all_lung(23;1.02e-08)													0.482558	237.694393	237.740779	83	89	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	62199792	62199792	11292	20	G	A	A	46	46	OPRL1	A	2	2
TMPRSS15	5651	broad.mit.edu	36	21	18697802	18697802	+	Silent	SNP	C	T	T			TCGA-12-0615-01	TCGA-12-0615-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr21:18697802C>T	uc002ykw.1	-	c.9G>A	c.(7-9)TCG>TCA	p.S3S		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	3	Cytoplasmic (Potential).				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|breast(1)	6														0.416667	136.157203	136.811587	45	63	CC		KEEP	---	---	---	---	capture			Silent	SNP	18697802	18697802	16787	21	C	T	T	31	31	TMPRSS15	T	1	1
CLDN17	26285	broad.mit.edu	36	21	30460716	30460716	+	Missense_Mutation	SNP	T	C	C			TCGA-12-0615-01	TCGA-12-0615-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr21:30460716T>C	uc002ynt.1	-	c.91A>G	c.(91-93)AGA>GGA	p.R31G		NM_012131	NP_036263	P56750	CLD17_HUMAN	claudin 17	31	Extracellular (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	Golgi apparatus|integral to membrane|tight junction	identical protein binding|structural molecule activity			ovary(2)	2														0.43949	228.957417	229.456169	69	88	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	30460716	30460716	3614	21	T	C	C	54	54	CLDN17	C	4	4
MX2	4600	broad.mit.edu	36	21	41684431	41684431	+	Missense_Mutation	SNP	G	C	C			TCGA-12-0615-01	TCGA-12-0615-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr21:41684431G>C	uc002yzf.1	+	c.802G>C	c.(802-804)GTG>CTG	p.V268L	MX2_uc002yzg.1_5'UTR	NM_002463	NP_002454	P20592	MX2_HUMAN	myxovirus resistance protein 2	268					response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			ovary(2)	2		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)												0.371094	325.077239	328.807847	95	161	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	41684431	41684431	10392	21	G	C	C	40	40	MX2	C	3	3
MKL1	57591	broad.mit.edu	36	22	39155662	39155662	+	Missense_Mutation	SNP	T	A	A			TCGA-12-0615-01	TCGA-12-0615-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr22:39155662T>A	uc003ayv.1	-	c.195A>T	c.(193-195)AGA>AGT	p.R65S	MKL1_uc003ayw.1_Missense_Mutation_p.R65S|MKL1_uc010gye.1_Missense_Mutation_p.R65S|MKL1_uc010gyf.1_Missense_Mutation_p.R65S	NM_020831	NP_065882	Q969V6	MKL1_HUMAN	megakaryoblastic leukemia 1 protein	65	Mediates interaction with SCAI and ACTB (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|nucleic acid binding|transcription coactivator activity			ovary(2)|central_nervous_system(1)	3										210				0.123077	7.757416	16.803119	8	57	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	39155662	39155662	9991	22	T	A	A	58	58	MKL1	A	4	4
CELSR1	9620	broad.mit.edu	36	22	45309450	45309450	+	Missense_Mutation	SNP	G	A	A			TCGA-12-0615-01	TCGA-12-0615-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr22:45309450G>A	uc003bhw.1	-	c.2282C>T	c.(2281-2283)GCG>GTG	p.A761V		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	761	Extracellular (Potential).|Cadherin 5.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			pancreas(2)|skin(1)	3		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)												0.453488	110.948821	111.104943	39	47	GG		KEEP	---	---	---	---	capture		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)	Missense_Mutation	SNP	45309450	45309450	3354	22	G	A	A	38	38	CELSR1	A	1	1
SCN7A	6332	broad.mit.edu	36	2	166970570	166970570	+	Silent	SNP	T	C	C			TCGA-12-0615-01	TCGA-12-0615-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr2:166970570T>C	uc002udu.1	-	c.4815A>G	c.(4813-4815)TTA>TTG	p.L1605L		NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	1605					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1														0.385827	338.612932	341.507574	98	156	TT		KEEP	---	---	---	---	capture			Silent	SNP	166970570	166970570	14405	2	T	C	C	53	53	SCN7A	C	4	4
DNAH7	56171	broad.mit.edu	36	2	196449577	196449577	+	Missense_Mutation	SNP	A	G	G			TCGA-12-0615-01	TCGA-12-0615-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr2:196449577A>G	uc002utj.2	-	c.6053T>C	c.(6052-6054)ATT>ACT	p.I2018T		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2018	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(2)	2														0.362205	152.719683	154.840099	46	81	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	196449577	196449577	4789	2	A	G	G	4	4	DNAH7	G	4	4
AAMP	14	broad.mit.edu	36	2	218839525	218839525	+	Silent	SNP	G	A	A			TCGA-12-0615-01	TCGA-12-0615-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr2:218839525G>A	uc002vhl.1	-	c.567C>T	c.(565-567)GTC>GTT	p.V189V	AAMP_uc002vhj.1_Silent_p.V169V|AAMP_uc002vhk.1_Silent_p.V188V|AAMP_uc010fvo.1_Silent_p.V188V	NM_001087	NP_001078	Q13685	AAMP_HUMAN	angio-associated, migratory cell protein	188	WD 3.				angiogenesis|cell differentiation|positive regulation of endothelial cell migration|smooth muscle cell migration	cell surface|cytoplasm|plasma membrane	heparin binding			ovary(1)	1		Renal(207;0.0474)												0.315068	63.687201	65.915118	23	50	GG		KEEP	---	---	---	---	capture		Epithelial(149;7.19e-07)|all cancers(144;0.000131)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)	Silent	SNP	218839525	218839525	18	2	G	A	A	41	41	AAMP	A	2	2
ZAP70	7535	broad.mit.edu	36	2	97720656	97720656	+	Missense_Mutation	SNP	G	A	A			TCGA-12-0615-01	TCGA-12-0615-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr2:97720656G>A	uc002syd.1	+	c.1487G>A	c.(1486-1488)CGC>CAC	p.R496H	ZAP70_uc002sye.1_Missense_Mutation_p.R386H|ZAP70_uc002syf.1_Missense_Mutation_p.R189H	NM_001079	NP_997402	P43403	ZAP70_HUMAN	zeta-chain associated protein kinase 70kDa	496	Protein kinase.				immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(3)|upper_aerodigestive_tract(1)|ovary(1)	5										138				0.724409	297.939852	303.706478	92	35	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	97720656	97720656	18097	2	G	A	A	38	38	ZAP70	A	1	1
LEPREL1	55214	broad.mit.edu	36	3	191183624	191183624	+	Splice_Site_SNP	SNP	C	T	T			TCGA-12-0615-01	TCGA-12-0615-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr3:191183624C>T	uc003fsf.1	-	c.1230_splice	c.e8-1	p.R410_splice	LEPREL1_uc003fsg.1_Splice_Site_SNP_p.R229_splice	NM_018192	NP_060662			leprecan-like 1 isoform a						negative regulation of cell proliferation|oxidation-reduction process	endoplasmic reticulum|Golgi apparatus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			breast(3)|ovary(1)	4	all_cancers(143;4.01e-10)|Ovarian(172;0.0925)				L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)									0.287273	235.806944	246.970876	79	196	CC		KEEP	---	---	---	---	capture	Lung(62;4.35e-05)	GBM - Glioblastoma multiforme(93;0.02)	Splice_Site_SNP	SNP	191183624	191183624	9054	3	C	T	T	24	24	LEPREL1	T	5	2
SHISA5	51246	broad.mit.edu	36	3	48513584	48513584	+	Missense_Mutation	SNP	G	A	A			TCGA-12-0615-01	TCGA-12-0615-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr3:48513584G>A	uc003ctp.1	-	c.223C>T	c.(223-225)CCT>TCT	p.P75S	SHISA5_uc003cto.1_Missense_Mutation_p.P44S|SHISA5_uc003ctq.1_Intron|SHISA5_uc003ctr.1_Missense_Mutation_p.P44S|SHISA5_uc003cts.1_Missense_Mutation_p.P44S	NM_016479	NP_057563	Q8N114	SHSA5_HUMAN	scotin	75	Extracellular (Potential).				apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade	endoplasmic reticulum membrane|integral to membrane|nuclear membrane	signal transducer activity|WW domain binding				0														0.241935	36.85509	40.661697	15	47	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	48513584	48513584	14775	3	G	A	A	42	42	SHISA5	A	2	2
ERC2	26059	broad.mit.edu	36	3	56444017	56444017	+	Missense_Mutation	SNP	C	T	T			TCGA-12-0615-01	TCGA-12-0615-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr3:56444017C>T	uc003dhr.1	-	c.59G>A	c.(58-60)CGT>CAT	p.R20H		NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	20						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2														0.218543	78.001295	89.019952	33	118	CC		KEEP	---	---	---	---	capture		KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)	Missense_Mutation	SNP	56444017	56444017	5404	3	C	T	T	19	19	ERC2	T	1	1
CNTN3	5067	broad.mit.edu	36	3	74399152	74399152	+	Missense_Mutation	SNP	C	A	A			TCGA-12-0615-01	TCGA-12-0615-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr3:74399152C>A	uc003dpm.1	-	c.2772G>T	c.(2770-2772)GAG>GAT	p.E924D		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3	924	Fibronectin type-III 4.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)	4		Lung NSC(201;0.138)|Lung SC(41;0.21)												0.229167	165.998964	185.37125	66	222	CC		KEEP	---	---	---	---	capture		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)	Missense_Mutation	SNP	74399152	74399152	3780	3	C	A	A	28	28	CNTN3	A	3	3
SFRP2	6423	broad.mit.edu	36	4	154922125	154922125	+	Silent	SNP	C	T	T			TCGA-12-0615-01	TCGA-12-0615-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr4:154922125C>T	uc003inv.1	-	c.816G>A	c.(814-816)TCG>TCA	p.S272S		NM_003013	NP_003004	Q96HF1	SFRP2_HUMAN	secreted frizzled-related protein 2 precursor	272	NTR.				brain development|cardiac left ventricle morphogenesis|cell-cell signaling|dermatome development|hemopoietic stem cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell growth|negative regulation of cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of gene-specific transcription|negative regulation of peptidyl-tyrosine phosphorylation|outflow tract morphogenesis|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell adhesion mediated by integrin|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of fat cell differentiation|positive regulation of gene-specific transcription from RNA polymerase II promoter|positive regulation of peptidyl-serine phosphorylation|regulation of stem cell division|sclerotome development	cytoplasm|extracellular matrix|extracellular space|plasma membrane	fibronectin binding|integrin binding|PDZ domain binding|receptor agonist activity|transcription repressor activity|Wnt receptor activity|Wnt-protein binding	p.S272S(1)		ovary(1)|central_nervous_system(1)	2	all_hematologic(180;0.093)	Renal(120;0.117)												0.402778	178.222724	179.412048	58	86	CC		KEEP	---	---	---	---	capture			Silent	SNP	154922125	154922125	14651	4	C	T	T	23	23	SFRP2	T	1	1
FRYL	285527	broad.mit.edu	36	4	48317543	48317543	+	Missense_Mutation	SNP	A	C	C			TCGA-12-0615-01	TCGA-12-0615-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr4:48317543A>C	uc003gyh.1	-	c.184T>G	c.(184-186)TCT>GCT	p.S62A	FRYL_uc003gyk.1_Missense_Mutation_p.S62A|FRYL_uc003gym.1_Missense_Mutation_p.S62A|FRYL_uc003gyl.1_Missense_Mutation_p.S113A	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	62					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1														0.47619	150.739973	150.791945	50	55	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	48317543	48317543	6314	4	A	C	C	11	11	FRYL	C	4	4
UGT2B17	7367	broad.mit.edu	36	4	69086152	69086152	+	Missense_Mutation	SNP	C	T	T			TCGA-12-0615-01	TCGA-12-0615-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr4:69086152C>T	uc003hea.1	-	c.1379G>A	c.(1378-1380)CGA>CAA	p.R460Q		NM_001077	NP_001068	O75795	UDB17_HUMAN	UDP glucuronosyltransferase 2 family,	460					steroid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)	1						Melanoma(18;649 833 28984 37818 38500)								0.398148	394.327089	397.2611	129	195	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	69086152	69086152	17517	4	C	T	T	31	31	UGT2B17	T	1	1
TRIM7	81786	broad.mit.edu	36	5	180554902	180554902	+	Missense_Mutation	SNP	A	G	G			TCGA-12-0615-01	TCGA-12-0615-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr5:180554902A>G	uc003mmz.1	-	c.1406T>C	c.(1405-1407)GTG>GCG	p.V469A	TRIM7_uc003mmv.1_Missense_Mutation_p.V287A|TRIM7_uc003mmw.1_Missense_Mutation_p.V261A|TRIM7_uc003mmy.1_Missense_Mutation_p.V261A|TRIM7_uc003mmx.1_Missense_Mutation_p.V261A	NM_203293	NP_976041	Q9C029	TRIM7_HUMAN	tripartite motif-containing 7 isoform 1	469	B30.2/SPRY.					cytoplasm|nucleus	zinc ion binding			ovary(1)|skin(1)	2	all_cancers(89;6.03e-06)|all_epithelial(37;7.1e-07)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.000172)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_lung(500;0.0221)|all_hematologic(541;0.0433)|Lung NSC(249;0.132)|Ovarian(839;0.238)				Esophageal Squamous(128;2258 2308 35507 48647)								0.272727	8.422282	8.933044	3	8	AA		KEEP	---	---	---	---	capture	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;2e-06)|Epithelial(171;1.35e-05)|OV - Ovarian serous cystadenocarcinoma(192;0.000128)|Kidney(146;0.0674)|GBM - Glioblastoma multiforme(465;0.0802)	Missense_Mutation	SNP	180554902	180554902	17092	5	A	G	G	6	6	TRIM7	G	4	4
RNF217	154214	broad.mit.edu	36	6	125420795	125420795	+	Silent	SNP	C	T	T			TCGA-12-0615-01	TCGA-12-0615-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr6:125420795C>T	uc003pzs.1	+	c.249C>T	c.(247-249)TGC>TGT	p.C83C	RNF217_uc003pzr.1_Silent_p.C140C|RNF217_uc003pzt.1_Non-coding_Transcript	NM_152553	NP_689766	Q8TC41	RN217_HUMAN	ring finger protein 217	83	IBR-type.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding				0														0.580645	163.332199	163.856201	54	39	CC		KEEP	---	---	---	---	capture	LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0162)	Silent	SNP	125420795	125420795	13959	6	C	T	T	26	26	RNF217	T	2	2
GLP1R	2740	broad.mit.edu	36	6	39141959	39141959	+	Silent	SNP	G	A	A			TCGA-12-0615-01	TCGA-12-0615-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr6:39141959G>A	uc003ooj.2	+	c.411G>A	c.(409-411)CCG>CCA	p.P137P	GLP1R_uc003ooh.2_Non-coding_Transcript|GLP1R_uc003ooi.2_Non-coding_Transcript	NM_002062	NP_002053	P43220	GLP1R_HUMAN	glucagon-like peptide 1 receptor	137	Extracellular (Potential).			P -> R (in Ref. 4; no nucleotide entry).|SP -> WG (in Ref. 1; AAA03614).	activation of adenylate cyclase activity|cAMP-mediated signaling|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	glucagon receptor activity|peptide receptor activity, G-protein coupled			lung(1)|pancreas(1)	2					Exenatide(DB01276)|Glucagon recombinant(DB00040)									0.353846	67.010716	68.232602	23	42	GG		KEEP	---	---	---	---	capture			Silent	SNP	39141959	39141959	6720	6	G	A	A	39	39	GLP1R	A	1	1
TRIM4	89122	broad.mit.edu	36	7	99345189	99345189	+	Missense_Mutation	SNP	C	T	T			TCGA-12-0615-01	TCGA-12-0615-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr7:99345189C>T	uc003usd.1	-	c.502G>A	c.(502-504)GTG>ATG	p.V168M	TRIM4_uc003use.1_Missense_Mutation_p.V142M|TRIM4_uc003usf.1_Missense_Mutation_p.V142M	NM_033017	NP_148977	Q9C037	TRIM4_HUMAN	tripartite motif protein TRIM4 isoform alpha	168					protein trimerization	cytoplasm|plasma membrane	zinc ion binding			ovary(1)|kidney(1)	2	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)	Ovarian(593;0.238)												0.275	56.407955	60.062842	22	58	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	99345189	99345189	17058	7	C	T	T	19	19	TRIM4	T	1	1
SLC25A32	81034	broad.mit.edu	36	8	104481900	104481900	+	Missense_Mutation	SNP	C	G	G			TCGA-12-0615-01	TCGA-12-0615-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr8:104481900C>G	uc003yll.1	-	c.863G>C	c.(862-864)AGA>ACA	p.R288T		NM_030780	NP_110407	Q9H2D1	MFTC_HUMAN	solute carrier family 25, member 32	288	Solcar 3.|Helical; Name=6; (Potential).				folic acid metabolic process|mitochondrial transport	integral to membrane|mitochondrial inner membrane	binding|folic acid transporter activity			ovary(1)	1					Folic Acid(DB00158)									0.396476	310.910006	313.03699	90	137	CC		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(57;2.79e-06)|STAD - Stomach adenocarcinoma(118;0.197)		Missense_Mutation	SNP	104481900	104481900	14993	8	C	G	G	32	32	SLC25A32	G	3	3
VCPIP1	80124	broad.mit.edu	36	8	67709361	67709361	+	Nonsense_Mutation	SNP	C	A	A			TCGA-12-0615-01	TCGA-12-0615-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr8:67709361C>A	uc003xwn.1	-	c.3598G>T	c.(3598-3600)GAG>TAG	p.E1200*		NM_025054	NP_079330	Q96JH7	VCIP1_HUMAN	valosin containing protein (p97)/p47 complex	1200					protein ubiquitination	endoplasmic reticulum|Golgi stack	ubiquitin-specific protease activity			ovary(2)|kidney(1)|central_nervous_system(1)|skin(1)	5		Lung NSC(129;0.142)|all_lung(136;0.227)				NSCLC(179;265 2915 6144 43644)				91				0.41573	319.16993	320.826771	111	156	CC		KEEP	---	---	---	---	capture	Epithelial(68;0.000771)|OV - Ovarian serous cystadenocarcinoma(28;0.00248)|all cancers(69;0.00296)|BRCA - Breast invasive adenocarcinoma(89;0.149)		Nonsense_Mutation	SNP	67709361	67709361	17706	8	C	A	A	30	30	VCPIP1	A	5	3
SVEP1	79987	broad.mit.edu	36	9	112213632	112213632	+	Silent	SNP	G	T	T			TCGA-12-0615-01	TCGA-12-0615-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr9:112213632G>T	uc010mtz.1	-	c.6180C>A	c.(6178-6180)CTC>CTA	p.L2060L	SVEP1_uc010mty.1_De_novo_Start_OutOfFrame	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	2060	Sushi 11.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7														0.485294	97.96791	97.980874	33	35	GG		KEEP	---	---	---	---	capture			Silent	SNP	112213632	112213632	15940	9	G	T	T	33	33	SVEP1	T	3	3
RECK	8434	broad.mit.edu	36	9	36050144	36050144	+	Missense_Mutation	SNP	C	G	G			TCGA-12-0615-01	TCGA-12-0615-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr9:36050144C>G	uc003zyv.1	+	c.263C>G	c.(262-264)TCT>TGT	p.S88C	RECK_uc010mld.1_Missense_Mutation_p.S88C|RECK_uc003zyu.2_Missense_Mutation_p.S88C|RECK_uc003zyw.1_De_novo_Start_OutOfFrame|RECK_uc010mle.1_Intron|RECK_uc003zyx.1_Non-coding_Transcript	NM_021111	NP_066934	O95980	RECK_HUMAN	RECK protein precursor	88	5 X Knot repeats.					anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			ovary(1)	1														0.367647	256.17283	259.314238	75	129	CC		KEEP	---	---	---	---	capture	LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)		Missense_Mutation	SNP	36050144	36050144	13669	9	C	G	G	32	32	RECK	G	3	3
TMEM2	23670	broad.mit.edu	36	9	73534881	73534881	+	Missense_Mutation	SNP	C	T	T			TCGA-12-0615-01	TCGA-12-0615-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr9:73534881C>T	uc004aij.1	-	c.1882G>A	c.(1882-1884)GGT>AGT	p.G628S	TMEM2_uc010mos.1_Missense_Mutation_p.G565S	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	628						integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)												0.418605	273.553482	274.808815	90	125	CC		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)	Missense_Mutation	SNP	73534881	73534881	16656	9	C	T	T	22	22	TMEM2	T	2	2
WNK2	65268	broad.mit.edu	36	9	95069876	95069876	+	Missense_Mutation	SNP	G	A	A			TCGA-12-0615-01	TCGA-12-0615-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr9:95069876G>A	uc004ati.1	+	c.3724G>A	c.(3724-3726)GAG>AAG	p.E1242K	WNK2_uc004atj.1_Missense_Mutation_p.E1242K|WNK2_uc004atk.2_Missense_Mutation_p.E879K	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1242					intracellular protein kinase cascade|protein phosphorylation		ATP binding|protein binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|stomach(1)|large_intestine(1)|central_nervous_system(1)	7										1420				0.473684	28.57416	28.585573	9	10	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	95069876	95069876	17952	9	G	A	A	37	37	WNK2	A	1	1
NANS	54187	broad.mit.edu	36	9	99862995	99862995	+	Silent	SNP	C	T	T			TCGA-12-0615-01	TCGA-12-0615-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr9:99862995C>T	uc004ayb.1	+	c.243C>T	c.(241-243)TAC>TAT	p.Y81Y	NANS_uc004ayc.1_Silent_p.Y81Y	NM_018946	NP_061819	Q9NR45	SIAS_HUMAN	N-acetylneuraminic acid phosphate synthase	81					lipopolysaccharide biosynthetic process	cytoplasm	N-acetylneuraminate synthase activity|N-acylneuraminate cytidylyltransferase activity|N-acylneuraminate-9-phosphate synthase activity				0		Acute lymphoblastic leukemia(62;0.0559)												0.408377	465.152188	467.946472	156	226	CC		KEEP	---	---	---	---	capture			Silent	SNP	99862995	99862995	10551	9	C	T	T	19	19	NANS	T	1	1
WWC3	55841	broad.mit.edu	36	X	10026544	10026544	+	Splice_Site_SNP	SNP	A	T	T			TCGA-12-0615-01	TCGA-12-0615-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chrX:10026544A>T	uc004csx.2	+	c.658_splice	c.e8-2	p.F220_splice	WWC3_uc010nds.1_Splice_Site_SNP|WWC3_uc010ndt.1_Splice_Site_SNP	NM_015691	NP_056506			WWC family member 3											ovary(4)	4														0.393162	135.549363	136.709908	46	71	AA		KEEP	---	---	---	---	capture			Splice_Site_SNP	SNP	10026544	10026544	17987	23	A	T	T	3	3	WWC3	T	5	4
TEX13A	56157	broad.mit.edu	36	X	104350530	104350530	+	Silent	SNP	G	A	A			TCGA-12-0615-01	TCGA-12-0615-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chrX:104350530G>A	uc004ema.1	-	c.1002C>T	c.(1000-1002)TCC>TCT	p.S334S	IL1RAPL2_uc004elz.1_Intron|TEX13A_uc004emb.1_Missense_Mutation_p.P335L	NM_031274	NP_112564	Q9BXU3	TX13A_HUMAN	testis expressed sequence 13A	334						intracellular	zinc ion binding			ovary(2)	2														0.452941	251.259303	251.586846	77	93	GG		KEEP	---	---	---	---	capture			Silent	SNP	104350530	104350530	16303	23	G	A	A	39	39	TEX13A	A	1	1
ODZ1	10178	broad.mit.edu	36	X	123342170	123342170	+	Missense_Mutation	SNP	C	A	A			TCGA-12-0615-01	TCGA-12-0615-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chrX:123342170C>A	uc010nqy.1	-	c.8096G>T	c.(8095-8097)GGT>GTT	p.G2699V	ODZ1_uc004euj.1_Missense_Mutation_p.G2692V	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1	2692	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	22										623				0.382134	479.558346	484.466829	154	249	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	123342170	123342170	11239	23	C	A	A	18	18	ODZ1	A	3	3
PDZD4	57595	broad.mit.edu	36	X	152722246	152722246	+	Missense_Mutation	SNP	C	T	T			TCGA-12-0615-01	TCGA-12-0615-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chrX:152722246C>T	uc004fja.1	-	c.2084G>A	c.(2083-2085)CGT>CAT	p.R695H	PDZD4_uc004fix.1_Missense_Mutation_p.R593H|PDZD4_uc004fiy.1_Missense_Mutation_p.R614H|PDZD4_uc004fiz.1_Missense_Mutation_p.R689H	NM_032512	NP_115901	Q76G19	PDZD4_HUMAN	PDZ domain containing 4	689						cell cortex				breast(1)	1	all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)													0.36	204.386754	207.819353	72	128	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	152722246	152722246	12124	23	C	T	T	19	19	PDZD4	T	1	1
IL1RAPL1	11141	broad.mit.edu	36	X	29883517	29883517	+	Missense_Mutation	SNP	C	G	G			TCGA-12-0615-01	TCGA-12-0615-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chrX:29883517C>G	uc004dby.2	+	c.1750C>G	c.(1750-1752)CTG>GTG	p.L584V		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	584	Cytoplasmic (Potential).|Interaction with NCS1.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5														0.328571	66.183985	68.017165	23	47	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	29883517	29883517	7962	23	C	G	G	28	28	IL1RAPL1	G	3	3
MXRA5	25878	broad.mit.edu	36	X	3238536	3238536	+	Missense_Mutation	SNP	G	T	T			TCGA-12-0615-01	TCGA-12-0615-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chrX:3238536G>T	uc004crg.2	-	c.7708C>A	c.(7708-7710)CCG>ACG	p.P2570T		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican	2570	Ig-like C2-type 10.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(23;0.00031)|Lung NSC(23;0.000946)												0.3125	25.757428	26.748763	10	22	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	3238536	3238536	10397	23	G	T	T	43	43	MXRA5	T	3	3
CXorf59	286464	broad.mit.edu	36	X	36013405	36013405	+	Missense_Mutation	SNP	C	T	T			TCGA-12-0615-01	TCGA-12-0615-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chrX:36013405C>T	uc004ddk.1	+	c.470C>T	c.(469-471)TCC>TTC	p.S157F		NM_173695	NP_775966	Q8N9S7	CX059_HUMAN	hypothetical protein LOC286464	157						integral to membrane				central_nervous_system(1)	1														0.453901	203.082929	203.344214	64	77	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	36013405	36013405	4279	23	C	T	T	30	30	CXorf59	T	2	2
DUXA	503835	broad.mit.edu	36	19	62361577	62361578	+	Frame_Shift_Ins	INS	-	T	T			TCGA-12-0615-01	TCGA-12-0615-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:62361577_62361578insT	uc002qoa.1	-	c.368_369insA	c.(367-369)AACfs	p.N123fs		NM_001012729	NP_001012747	A6NLW8	DUXA_HUMAN	double homeobox A	123	Homeobox 2.				regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0123)										0.41			115	167				---	---	---	---	capture_indel			Frame_Shift_Ins	INS	62361577	62361578	5020	19	-	T	T	44	44	DUXA	T	5	5
WDR1	9948	broad.mit.edu	36	4	9695167	9695168	+	Frame_Shift_Ins	INS	-	T	T			TCGA-12-0615-01	TCGA-12-0615-01										Phase_I	Unspecified				Illumina GAIIx	g.chr4:9695167_9695168insT	uc003gmf.1	-	c.1036_1037insA	c.(1036-1038)ATTfs	p.I346fs	WDR1_uc003gmg.1_Frame_Shift_Ins_p.I206fs|WDR1_uc003gmh.1_Non-coding_Transcript|WDR1_uc010idm.1_5'Flank	NM_017491	NP_059830	O75083	WDR1_HUMAN	WD repeat-containing protein 1 isoform 1	346	WD 6.				platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			ovary(2)|pancreas(1)	3				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)										0.31			16	36				---	---	---	---	capture_indel			Frame_Shift_Ins	INS	9695167	9695168	17845	4	-	T	T	4	4	WDR1	T	5	5
