Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	i_TCGAscape_Amplification_Peaks	i_TCGAscape_Deletion_Peaks	DrugBank	i_ACHILLES_Top_Genes	i_CCLE_ONCOMAP_overlapping_mutations	i_CCLE_ONCOMAP_total_mutations_in_gene	i_CCLE_SEQ_overlapping_mutations	i_CCLE_SEQ_total_mutations_in_gene	MUTSIG_Significant_Genes	OREGANNO_ID	OREGANNO_Values	i_tumor_f	i_init_t_lod	i_t_lod_fstar	i_t_alt_count	i_t_ref_count	i_normal_best_gt	i_failure_reasons	i_judgement	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	dataset	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	type	classification	start	end	gene	chr	ref_allele	tum_allele1	tum_allele2	context_orig	context65	gene_name	newbase	categ	categ_ignoring_null_categ
PDSS1	23590	broad.mit.edu	36	10	27075375	27075375	+	Missense_Mutation	SNP	G	C	C			TCGA-14-3477-01	TCGA-14-3477-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr10:27075375G>C	uc001isv.1	+	c.1215G>C	c.(1213-1215)CAG>CAC	p.Q405H	PDSS1_uc001isw.1_3'UTR	NM_014317	NP_055132	Q5T2R2	DPS1_HUMAN	prenyl diphosphate synthase, subunit 1	405					isoprenoid biosynthetic process|ubiquinone biosynthetic process	mitochondrion	metal ion binding|protein heterodimerization activity				0														0.125984	22.509968	39.855829	16	111	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	27075375	27075375	12114	10	G	C	C	34	34	PDSS1	C	3	3
ABCG4	64137	broad.mit.edu	36	11	118532594	118532594	+	Missense_Mutation	SNP	C	G	G			TCGA-14-3477-01	TCGA-14-3477-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr11:118532594C>G	uc001pvs.1	+	c.921C>G	c.(919-921)GAC>GAG	p.D307E	ABCG4_uc009zar.1_Missense_Mutation_p.D307E	NM_022169	NP_071452	Q9H172	ABCG4_HUMAN	ATP-binding cassette, subfamily G, member 4	307	Cytoplasmic (Potential).				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)										0.192982	22.191991	27.208697	11	46	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	118532594	118532594	71	11	C	G	G	20	20	ABCG4	G	3	3
GAB2	9846	broad.mit.edu	36	11	77612112	77612112	+	Missense_Mutation	SNP	G	A	A			TCGA-14-3477-01	TCGA-14-3477-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr11:77612112G>A	uc001ozh.1	-	c.1561C>T	c.(1561-1563)CGG>TGG	p.R521W	GAB2_uc001ozg.1_Missense_Mutation_p.R483W	NM_080491	NP_036428	Q9UQC2	GAB2_HUMAN	GRB2-associated binding protein 2 isoform a	521					osteoclast differentiation|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mast cell degranulation	cytosol|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|transmembrane receptor protein tyrosine kinase adaptor activity			ovary(5)|lung(1)	6	all_cancers(14;3.31e-18)|all_epithelial(13;5.3e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.58e-23)											0.421053	191.489953	192.310822	64	88	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	77612112	77612112	6400	11	G	A	A	37	37	GAB2	A	1	1
ACSM4	341392	broad.mit.edu	36	12	7362046	7362046	+	Splice_Site_SNP	SNP	G	A	A			TCGA-14-3477-01	TCGA-14-3477-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr12:7362046G>A	uc001qsx.1	+	c.e5_splice_site				NM_001080454	NP_001073923			acyl-CoA synthetase medium-chain family member						fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding				0														0.149194	63.208503	92.491928	37	211	GG		KEEP	---	---	---	---	capture			Splice_Site_SNP	SNP	7362046	7362046	187	12	G	A	A	40	40	ACSM4	A	5	1
SLC28A2	9153	broad.mit.edu	36	15	43344229	43344229	+	Missense_Mutation	SNP	G	A	A			TCGA-14-3477-01	TCGA-14-3477-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr15:43344229G>A	uc001zva.1	+	c.673G>A	c.(673-675)GTA>ATA	p.V225I		NM_004212	NP_004203	O43868	S28A2_HUMAN	solute carrier family 28 (sodium-coupled	225					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding|nucleoside:sodium symporter activity|purine nucleoside transmembrane transporter activity			ovary(4)	4		all_cancers(109;8.53e-07)|all_epithelial(112;1.39e-05)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.77e-16)|GBM - Glioblastoma multiforme(94;2.71e-06)		NSCLC(92;493 1501 26361 28917 47116)								0.416058	167.74774	168.590827	57	80	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	43344229	43344229	15029	15	G	A	A	48	48	SLC28A2	A	2	2
PIF1	80119	broad.mit.edu	36	15	62897565	62897565	+	Missense_Mutation	SNP	C	T	T	rs61128222	unknown	TCGA-14-3477-01	TCGA-14-3477-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr15:62897565C>T	uc002ant.1	-	c.1472G>A	c.(1471-1473)CGG>CAG	p.R491Q	PIF1_uc002anr.1_Missense_Mutation_p.R39Q|PIF1_uc002ans.1_Missense_Mutation_p.R182Q	NM_025049	NP_079325	Q9H611	PIF1_HUMAN	DNA helicase homolog PIF1	491	Hydrolyzes ATP in the presence of both magnesium and single-stranded DNA; weak activity in the presence of RNA or double-stranded DNA; No unwinding activity.				negative regulation of telomerase activity|regulation of telomere maintenance	nuclear chromosome, telomeric region	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' DNA/RNA helicase activity|magnesium ion binding|single-stranded DNA-dependent ATP-dependent DNA helicase activity|telomeric DNA binding				0														0.135135	15.808398	25.348593	10	64	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	62897565	62897565	12307	15	C	T	T	23	23	PIF1	T	1	1
KRT13	3860	broad.mit.edu	36	17	36913190	36913190	+	Missense_Mutation	SNP	C	T	T			TCGA-14-3477-01	TCGA-14-3477-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr17:36913190C>T	uc002hwu.1	-	c.610G>A	c.(610-612)GTG>ATG	p.V204M	KRT13_uc002hwv.1_Missense_Mutation_p.V204M|KRT13_uc002hww.1_Missense_Mutation_p.V97M|KRT13_uc010cxo.1_Missense_Mutation_p.V204M|KRT13_uc002hwx.1_Missense_Mutation_p.V192M	NM_153490	NP_705694	P13646	K1C13_HUMAN	keratin 13 isoform a	204	Coil 1B.|Rod.				epidermis development	intermediate filament	structural molecule activity			ovary(2)|pancreas(1)	3		Breast(137;0.000286)												0.304636	125.616587	130.745345	46	105	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	36913190	36913190	8765	17	C	T	T	19	19	KRT13	T	1	1
ERN1	2081	broad.mit.edu	36	17	59479003	59479003	+	Missense_Mutation	SNP	C	T	T			TCGA-14-3477-01	TCGA-14-3477-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr17:59479003C>T	uc002jdz.2	-	c.2476G>A	c.(2476-2478)GTG>ATG	p.V826M		NM_001433	NP_001424	O75460	ERN1_HUMAN	endoplasmic reticulum to nucleus signalling 1	826	Cytoplasmic (Potential).|Protein kinase.				activation of signaling protein activity involved in unfolded protein response|apoptosis|cell cycle arrest|induction of apoptosis|mRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to endoplasmic reticulum membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(4)|lung(2)|stomach(1)|ovary(1)|kidney(1)	9										295				0.137097	22.89498	38.712902	17	107	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	59479003	59479003	5430	17	C	T	T	17	17	ERN1	T	2	2
CLDN7	1366	broad.mit.edu	36	17	7104543	7104543	+	Silent	SNP	T	C	C			TCGA-14-3477-01	TCGA-14-3477-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr17:7104543T>C	uc002gfm.2	-	c.510A>G	c.(508-510)GCA>GCG	p.A170A	CLDN7_uc010cmc.1_Missense_Mutation_p.Q142R|CLDN7_uc002gfn.2_Silent_p.A170A	NM_001307	NP_001298	O95471	CLD7_HUMAN	claudin 7	170	Helical; (Potential).				calcium-independent cell-cell adhesion	integral to membrane|lateral plasma membrane|tight junction	identical protein binding|structural molecule activity			ovary(1)	1														0.384615	6.920589	7.120147	5	8	TT		KEEP	---	---	---	---	capture			Silent	SNP	7104543	7104543	3627	17	T	C	C	55	55	CLDN7	C	4	4
KCNC4	3749	broad.mit.edu	36	1	110567443	110567443	+	Missense_Mutation	SNP	C	T	T			TCGA-14-3477-01	TCGA-14-3477-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:110567443C>T	uc009wfr.1	+	c.1013C>T	c.(1012-1014)GCG>GTG	p.A338V	KCNC4_uc001dzf.1_Missense_Mutation_p.A338V|KCNC4_uc001dzg.1_Missense_Mutation_p.A338V|KCNC4_uc001dzh.1_Missense_Mutation_p.A338V|KCNC4_uc001dzi.1_Non-coding_Transcript	NM_001039574	NP_001034663	Q03721	KCNC4_HUMAN	Shaw-related voltage-gated potassium channel	338					synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3		all_cancers(81;9.88e-06)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0238)|all cancers(265;0.0693)|Epithelial(280;0.0748)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.135)										0.25	22.845709	25.108949	10	30	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	110567443	110567443	8322	1	C	T	T	27	27	KCNC4	T	1	1
TNFRSF8	943	broad.mit.edu	36	1	12094558	12094558	+	Silent	SNP	G	A	A			TCGA-14-3477-01	TCGA-14-3477-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:12094558G>A	uc001atq.1	+	c.693G>A	c.(691-693)CAG>CAA	p.Q231Q		NM_001243	NP_001234	P28908	TNR8_HUMAN	tumor necrosis factor receptor superfamily,	231	Extracellular (Potential).|TNFR-Cys 4.				cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane				skin(2)|ovary(1)|pancreas(1)|central_nervous_system(1)	5	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)						756				0.25	32.048184	35.003976	13	39	GG		KEEP	---	---	---	---	capture			Silent	SNP	12094558	12094558	16840	1	G	A	A	34	34	TNFRSF8	A	2	2
PAQR7	164091	broad.mit.edu	36	1	26062149	26062149	+	Missense_Mutation	SNP	T	C	C			TCGA-14-3477-01	TCGA-14-3477-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr1:26062149T>C	uc001bkx.1	-	c.769A>G	c.(769-771)ACC>GCC	p.T257A	PAQR7_uc009vsa.1_Missense_Mutation_p.T257A	NM_178422	NP_848509	Q86WK9	MPRA_HUMAN	progestin and adipoQ receptor family member VII	257	Helical; Name=5; (Potential).				cell differentiation|multicellular organismal development|oogenesis	integral to membrane|plasma membrane	receptor activity|steroid binding			breast(3)	3		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.16e-25)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000724)|BRCA - Breast invasive adenocarcinoma(304;0.000965)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0136)|READ - Rectum adenocarcinoma(331;0.0649)		Esophageal Squamous(111;1206 1556 18433 19151 38418)								0.231884	36.270582	40.813337	16	53	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	26062149	26062149	11857	1	T	C	C	57	57	PAQR7	C	4	4
LRRC8B	23507	broad.mit.edu	36	1	89822735	89822735	+	Silent	SNP	T	G	G			TCGA-14-3477-01	TCGA-14-3477-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr1:89822735T>G	uc001dnh.1	+	c.1938T>G	c.(1936-1938)GCT>GCG	p.A646A	LRRC8B_uc001dni.1_Silent_p.A646A|LRRC8B_uc001dnj.1_Silent_p.A646A	NM_015350	NP_056165	Q6P9F7	LRC8B_HUMAN	leucine rich repeat containing 8 family, member	646	LRR 8.					integral to membrane				ovary(2)	2		all_lung(203;0.17)		all cancers(265;0.00515)|Epithelial(280;0.0241)										0.493976	241.127962	241.133403	82	84	TT		KEEP	---	---	---	---	capture			Silent	SNP	89822735	89822735	9398	1	T	G	G	56	56	LRRC8B	G	4	4
BAZ2B	29994	broad.mit.edu	36	2	159913778	159913778	+	Missense_Mutation	SNP	T	C	C			TCGA-14-3477-01	TCGA-14-3477-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr2:159913778T>C	uc002uao.1	-	c.5123A>G	c.(5122-5124)AAA>AGA	p.K1708R	BAZ2B_uc002uap.1_Missense_Mutation_p.K1672R	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1708					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|transcription regulator activity|zinc ion binding			ovary(3)	3														0.371429	196.437619	198.975745	65	110	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	159913778	159913778	1353	2	T	C	C	64	64	BAZ2B	C	4	4
ABCB11	8647	broad.mit.edu	36	2	169501040	169501040	+	Silent	SNP	C	T	T			TCGA-14-3477-01	TCGA-14-3477-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr2:169501040C>T	uc002ueo.1	-	c.2760G>A	c.(2758-2760)AGG>AGA	p.R920R		NM_003742	NP_003733	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	920	Cytoplasmic (Potential).|ABC transmembrane type-1 2.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			ovary(2)|large_intestine(2)|breast(1)	5					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)									0.131783	42.269976	76.295985	34	224	CC		KEEP	---	---	---	---	capture			Silent	SNP	169501040	169501040	43	2	C	T	T	30	30	ABCB11	T	2	2
ITGA4	3676	broad.mit.edu	36	2	182103552	182103552	+	Silent	SNP	G	A	A			TCGA-14-3477-01	TCGA-14-3477-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr2:182103552G>A	uc002unu.1	+	c.2595G>A	c.(2593-2595)CAG>CAA	p.Q865Q	ITGA4_uc002unv.1_Silent_p.Q110Q	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	865	Extracellular (Potential).				B cell differentiation|blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)									0.141026	36.743125	56.143175	22	134	GG		KEEP	---	---	---	---	capture			Silent	SNP	182103552	182103552	8182	2	G	A	A	34	34	ITGA4	A	2	2
ECEL1	9427	broad.mit.edu	36	2	233053147	233053147	+	Missense_Mutation	SNP	T	C	C			TCGA-14-3477-01	TCGA-14-3477-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr2:233053147T>C	uc002vsv.2	-	c.2288A>G	c.(2287-2289)GAC>GGC	p.D763G	ECEL1_uc010fya.1_Missense_Mutation_p.D761G|ECEL1_uc010fyb.1_Missense_Mutation_p.D470G	NM_004826	NP_004817	O95672	ECEL1_HUMAN	endothelin converting enzyme-like 1	763	Lumenal (Potential).			D -> V (in Ref. 1; CAA76113).	neuropeptide signaling pathway|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity			central_nervous_system(2)	2		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000771)|Lung(119;0.00213)|LUSC - Lung squamous cell carcinoma(224;0.00746)										0.4	38.007004	38.349354	14	21	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	233053147	233053147	5078	2	T	C	C	58	58	ECEL1	C	4	4
RNASEH1	246243	broad.mit.edu	36	2	3574579	3574579	+	Splice_Site_SNP	SNP	T	A	A			TCGA-14-3477-01	TCGA-14-3477-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr2:3574579T>A	uc002qxt.1	-	c.e5_splice_site			RNASEH1_uc002qxs.1_Splice_Site_SNP	NM_002936	NP_002927			ribonuclease H1						RNA catabolic process	cytoplasm	magnesium ion binding|ribonuclease H activity|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.0713)|Epithelial(75;0.167)|all cancers(51;0.22)										0.304878	140.493959	146.061069	50	114	TT		KEEP	---	---	---	---	capture			Splice_Site_SNP	SNP	3574579	3574579	13888	2	T	A	A	55	55	RNASEH1	A	5	4
CAND2	23066	broad.mit.edu	36	3	12833724	12833724	+	Missense_Mutation	SNP	G	T	T			TCGA-14-3477-01	TCGA-14-3477-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr3:12833724G>T	uc003bxj.1	+	c.2014G>T	c.(2014-2016)GTA>TTA	p.V672L	CAND2_uc003bxk.1_Missense_Mutation_p.V269L	NM_012298	NP_036430	O75155	CAND2_HUMAN	TBP-interacting protein	765	HEAT 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|transcription activator activity			pancreas(1)	1						GBM(43;676 868 1633 6395 37496)								0.294118	11.566918	12.212851	5	12	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	12833724	12833724	2733	3	G	T	T	44	44	CAND2	T	3	3
SPATA16	83893	broad.mit.edu	36	3	174157184	174157184	+	Missense_Mutation	SNP	G	A	A			TCGA-14-3477-01	TCGA-14-3477-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr3:174157184G>A	uc003fin.2	-	c.1058C>T	c.(1057-1059)GCA>GTA	p.A353V		NM_031955	NP_114161	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	353					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			ovary(2)	2	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)											0.579545	166.43703	166.922643	51	37	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	174157184	174157184	15509	3	G	A	A	46	46	SPATA16	A	2	2
TBL1XR1	79718	broad.mit.edu	36	3	178254320	178254320	+	Missense_Mutation	SNP	C	G	G			TCGA-14-3477-01	TCGA-14-3477-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr3:178254320C>G	uc003fiw.2	-	c.139G>C	c.(139-141)GCT>CCT	p.A47P	TBL1XR1_uc003fix.2_Missense_Mutation_p.A47P|TBL1XR1_uc003fiy.2_Missense_Mutation_p.A47P	NM_024665	NP_078941	Q9BZK7	TBL1R_HUMAN	transducin (beta)-like 1 X-linked receptor 1	47	F-box-like.				canonical Wnt receptor signaling pathway|cellular lipid metabolic process|chromatin modification|negative regulation of gene-specific transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|promoter binding|protein N-terminus binding|transcription activator activity|transcription corepressor activity			ovary(1)	1	all_cancers(143;1.44e-17)|Ovarian(172;0.00163)|Breast(254;0.214)	Acute lymphoblastic leukemia(1;0.00599)|all_hematologic(1;0.0632)|Prostate(884;0.215)	OV - Ovarian serous cystadenocarcinoma(80;9.83e-31)											0.176471	41.533505	53.267661	21	98	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	178254320	178254320	16166	3	C	G	G	27	27	TBL1XR1	G	3	3
UBA7	7318	broad.mit.edu	36	3	49826053	49826053	+	Missense_Mutation	SNP	T	C	C			TCGA-14-3477-01	TCGA-14-3477-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr3:49826053T>C	uc003cxr.1	-	c.88A>G	c.(88-90)ATT>GTT	p.I30V		NM_003335	NP_003326	P41226	UBA7_HUMAN	ubiquitin-like modifier activating enzyme 7	30	2 approximate repeats.|1-1.				ISG15-protein conjugation|negative regulation of type I interferon production	cytosol	ATP binding|ISG15 activating enzyme activity|ligase activity			ovary(1)|pancreas(1)	2				BRCA - Breast invasive adenocarcinoma(193;3.58e-06)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)										0.375	22.966772	23.296708	9	15	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	49826053	49826053	17390	3	T	C	C	50	50	UBA7	C	4	4
UCHL1	7345	broad.mit.edu	36	4	40964806	40964806	+	Missense_Mutation	SNP	G	A	A			TCGA-14-3477-01	TCGA-14-3477-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr4:40964806G>A	uc003gvo.1	+	c.631G>A	c.(631-633)GAA>AAA	p.E211K	UCHL1_uc003gvp.1_Missense_Mutation_p.E130K|UCHL1_uc003gvq.1_Missense_Mutation_p.E130K|UCHL1_uc003gvr.1_Missense_Mutation_p.E130K|UCHL1_uc003gvs.1_Missense_Mutation_p.E130K	NM_004181	NP_004172	P09936	UCHL1_HUMAN	ubiquitin carboxyl-terminal esterase L1	211	Interaction with ubiquitin.				cell death|negative regulation of MAP kinase activity|protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus|plasma membrane	alpha-2A adrenergic receptor binding|cysteine-type endopeptidase activity|ligase activity|omega peptidase activity|ubiquitin binding|ubiquitin thiolesterase activity			central_nervous_system(1)	1														0.116883	11.920059	23.036769	9	68	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	40964806	40964806	17478	4	G	A	A	33	33	UCHL1	A	2	2
SGK1	6446	broad.mit.edu	36	6	134533913	134533914	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-14-3477-01	TCGA-14-3477-01										Phase_I	Unspecified				Illumina GAIIx	g.chr6:134533913_134533914GG>AA	uc003qeo.2	-	c.1263_1264CC>TT	c.(1261-1266)CACCTC>CATTTC	p.L422F	SGK1_uc003qen.2_Missense_Mutation_p.L327F	NM_005627	NP_005618	O00141	SGK1_HUMAN	serum/glucocorticoid regulated kinase 1 isoform	327	Protein kinase.				apoptosis|protein phosphorylation|response to stress|sodium ion transport	endoplasmic reticulum|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|lung(1)|central_nervous_system(1)	3	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00317)|GBM - Glioblastoma multiforme(68;0.00847)						161				0.289474	27.105297	28.618178	11	27	GG		KEEP	---	---	---	---	capture			Missense_Mutation	DNP	134533913	134533914	14698	6	GG	AA	AA	35	35	SGK1	AA	2	2
SYNE1	23345	broad.mit.edu	36	6	152570825	152570825	+	Missense_Mutation	SNP	G	C	C			TCGA-14-3477-01	TCGA-14-3477-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr6:152570825G>C	uc010kiw.1	-	c.22799C>G	c.(22798-22800)GCA>GGA	p.A7600G	SYNE1_uc003qor.2_Missense_Mutation_p.A500G|SYNE1_uc010kiv.1_Missense_Mutation_p.A2124G|SYNE1_uc003qos.2_Missense_Mutation_p.A2124G|SYNE1_uc003qot.2_Missense_Mutation_p.A7529G|SYNE1_uc003qou.2_Missense_Mutation_p.A7600G	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7600	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|ovary(8)|large_intestine(5)|pancreas(2)	30		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)										0.334302	338.204152	346.570119	115	229	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	152570825	152570825	15966	6	G	C	C	46	46	SYNE1	C	3	3
PDCD2	5134	broad.mit.edu	36	6	170728638	170728638	+	Missense_Mutation	SNP	G	T	T			TCGA-14-3477-01	TCGA-14-3477-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr6:170728638G>T	uc003qxw.1	-	c.969C>A	c.(967-969)AGC>AGA	p.S323R	PDCD2_uc003qxv.1_Missense_Mutation_p.S290R	NM_002598	NP_002589	Q16342	PDCD2_HUMAN	programmed cell death 2 isoform 1	323					apoptosis	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding				0		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.91e-23)|BRCA - Breast invasive adenocarcinoma(81;4.82e-06)|GBM - Glioblastoma multiforme(31;0.142)		Colon(60;1476 1726 39478)								0.362832	117.142309	119.013858	41	72	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	170728638	170728638	12040	6	G	T	T	34	34	PDCD2	T	3	3
PDCD2	5134	broad.mit.edu	36	6	170729872	170729872	+	Missense_Mutation	SNP	G	C	C			TCGA-14-3477-01	TCGA-14-3477-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr6:170729872G>C	uc003qxw.1	-	c.874C>G	c.(874-876)CAG>GAG	p.Q292E	PDCD2_uc003qxv.1_Missense_Mutation_p.Q259E|PDCD2_uc003qxx.1_Missense_Mutation_p.Q292E	NM_002598	NP_002589	Q16342	PDCD2_HUMAN	programmed cell death 2 isoform 1	292					apoptosis	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding				0		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.91e-23)|BRCA - Breast invasive adenocarcinoma(81;4.82e-06)|GBM - Glioblastoma multiforme(31;0.142)		Colon(60;1476 1726 39478)								0.483333	89.368823	89.383435	29	31	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	170729872	170729872	12040	6	G	C	C	47	47	PDCD2	C	3	3
FAM83B	222584	broad.mit.edu	36	6	54913474	54913474	+	Silent	SNP	C	T	T			TCGA-14-3477-01	TCGA-14-3477-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr6:54913474C>T	uc003pck.1	+	c.1746C>T	c.(1744-1746)GAC>GAT	p.D582D		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	582										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)													0.104167	8.884537	23.846527	10	86	CC		KEEP	---	---	---	---	capture			Silent	SNP	54913474	54913474	5860	6	C	T	T	17	17	FAM83B	T	2	2
ZNF800	168850	broad.mit.edu	36	7	126801489	126801489	+	Silent	SNP	T	C	C			TCGA-14-3477-01	TCGA-14-3477-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr7:126801489T>C	uc010lla.1	-	c.1137A>G	c.(1135-1137)CAA>CAG	p.Q379Q	ZNF800_uc003vlw.1_Silent_p.Q282Q|ZNF800_uc003vlx.1_Silent_p.Q379Q|ZNF800_uc003vly.1_Silent_p.Q379Q	NM_176814	NP_789784	Q2TB10	ZN800_HUMAN	zinc finger protein 800	379	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1														0.207143	71.398969	82.523243	29	111	TT		KEEP	---	---	---	---	capture			Silent	SNP	126801489	126801489	18767	7	T	C	C	64	64	ZNF800	C	4	4
CASD1	64921	broad.mit.edu	36	7	94012833	94012833	+	Missense_Mutation	SNP	T	C	C			TCGA-14-3477-01	TCGA-14-3477-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr7:94012833T>C	uc003uni.2	+	c.1517T>C	c.(1516-1518)ATA>ACA	p.I506T	CASD1_uc003unj.2_Missense_Mutation_p.I506T	NM_022900	NP_075051	Q96PB1	CASD1_HUMAN	CAS1 domain containing 1	506	Helical; (Potential).					integral to membrane				ovary(2)	2	all_cancers(62;6.71e-10)|all_epithelial(64;5e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)											0.260465	154.404728	165.569885	56	159	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	94012833	94012833	2783	7	T	C	C	49	49	CASD1	C	4	4
DOCK5	80005	broad.mit.edu	36	8	25286008	25286008	+	Missense_Mutation	SNP	C	T	T			TCGA-14-3477-01	TCGA-14-3477-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr8:25286008C>T	uc003xeg.1	+	c.3541C>T	c.(3541-3543)CGG>TGG	p.R1181W	DOCK5_uc010luf.1_Non-coding_Transcript|PPP2R2A_uc003xek.1_5'UTR|DOCK5_uc003xei.1_Missense_Mutation_p.R751W|DOCK5_uc003xej.1_Non-coding_Transcript|DOCK5_uc003xeh.1_Missense_Mutation_p.R895W	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	1181	DHR-2.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		Pancreas(145;34 1887 3271 10937 30165)								0.126437	29.473151	53.13583	22	152	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	25286008	25286008	4874	8	C	T	T	23	23	DOCK5	T	1	1
DOCK5	80005	broad.mit.edu	36	8	25290846	25290846	+	Missense_Mutation	SNP	G	C	C			TCGA-14-3477-01	TCGA-14-3477-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr8:25290846G>C	uc003xeg.1	+	c.3925G>C	c.(3925-3927)GAC>CAC	p.D1309H	PPP2R2A_uc003xek.1_Missense_Mutation_p.D98H|DOCK5_uc003xei.1_Missense_Mutation_p.D879H|DOCK5_uc003xej.1_Non-coding_Transcript	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	1309	DHR-2.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		Pancreas(145;34 1887 3271 10937 30165)								0.125874	26.257179	45.791946	18	125	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	25290846	25290846	4874	8	G	C	C	37	37	DOCK5	C	3	3
MYST3	7994	broad.mit.edu	36	8	41908973	41908973	+	Silent	SNP	C	T	T			TCGA-14-3477-01	TCGA-14-3477-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr8:41908973C>T	uc010lxb.1	-	c.5922G>A	c.(5920-5922)GGG>GGA	p.G1974G	MYST3_uc010lxc.1_Silent_p.G1974G|MYST3_uc003xon.2_Silent_p.G1974G	NM_001099412	NP_006757	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	1974	Met-rich.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription activator activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(3)|central_nervous_system(1)|pancreas(1)	5	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)							476				0.145038	118.248939	181.805412	76	448	CC		KEEP	---	---	---	---	capture			Silent	SNP	41908973	41908973	10499	8	C	T	T	30	30	MYST3	T	2	2
FIBCD1	84929	broad.mit.edu	36	9	132769451	132769451	+	Missense_Mutation	SNP	C	T	T			TCGA-14-3477-01	TCGA-14-3477-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr9:132769451C>T	uc004bzz.1	-	c.1207G>A	c.(1207-1209)GCC>ACC	p.A403T		NM_032843	NP_116232	Q8N539	FBCD1_HUMAN	fibrinogen C domain containing 1	403	Fibrinogen C-terminal.|Extracellular (Potential).				signal transduction	extracellular space|integral to membrane	chitin binding|metal ion binding|receptor binding				0	all_hematologic(7;0.0028)			OV - Ovarian serous cystadenocarcinoma(145;3.52e-05)|Epithelial(140;0.00019)										0.16	12.973117	18.476297	8	42	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	132769451	132769451	6122	9	C	T	T	27	27	FIBCD1	T	1	1
TLR7	51284	broad.mit.edu	36	X	12816087	12816087	+	Missense_Mutation	SNP	A	G	G			TCGA-14-3477-01	TCGA-14-3477-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chrX:12816087A>G	uc004cvc.1	+	c.2539A>G	c.(2539-2541)ATA>GTA	p.I847V		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7	847	Helical; (Potential).				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of inflammatory response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(1)	1					Imiquimod(DB00724)					69				0.214844	246.766551	285.216494	110	402	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	12816087	12816087	16486	23	A	G	G	8	8	TLR7	G	4	4
BRCC3	79184	broad.mit.edu	36	X	153997658	153997658	+	Splice_Site_SNP	SNP	G	T	T			TCGA-14-3477-01	TCGA-14-3477-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chrX:153997658G>T	uc004fna.1	+	c.e9_splice_site			BRCC3_uc004fnb.1_Splice_Site_SNP	NM_024332	NP_077308			BRCA1/BRCA2-containing complex, subunit 3						double-strand break repair|G2/M transition DNA damage checkpoint|histone H2A K63-linked deubiquitination|positive regulation of DNA repair|response to X-ray	BRCA1-A complex|BRISC complex|nuclear ubiquitin ligase complex	enzyme regulator activity|metal ion binding|metallopeptidase activity|polyubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(3)|large_intestine(1)|ovary(1)	5	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)									82				0.342105	36.063221	36.900386	13	25	GG		KEEP	---	---	---	---	capture			Splice_Site_SNP	SNP	153997658	153997658	1531	23	G	T	T	44	44	BRCC3	T	5	3
SH3KBP1	30011	broad.mit.edu	36	X	19611967	19611967	+	Silent	SNP	G	T	T			TCGA-14-3477-01	TCGA-14-3477-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chrX:19611967G>T	uc004czm.1	-	c.621C>A	c.(619-621)CCC>CCA	p.P207P	SH3KBP1_uc004czl.1_Silent_p.P170P	NM_031892	NP_114098	Q96B97	SH3K1_HUMAN	SH3-domain kinase binding protein 1 isoform a	207					apoptosis|cell-cell signaling|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytoplasmic vesicle membrane|cytoskeleton|cytosol|focal adhesion|nucleus|synapse|synaptosome	SH3 domain binding				0														0.200608	146.18652	173.591557	66	263	GG		KEEP	---	---	---	---	capture			Silent	SNP	19611967	19611967	14747	23	G	T	T	47	47	SH3KBP1	T	3	3
MED14	9282	broad.mit.edu	36	X	40419495	40419495	+	Silent	SNP	G	A	A			TCGA-14-3477-01	TCGA-14-3477-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chrX:40419495G>A	uc004dex.2	-	c.2943C>T	c.(2941-2943)GAC>GAT	p.D981D		NM_004229	NP_004220	O60244	MED14_HUMAN	mediator complex subunit 14	981					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription mediator activity|thyroid hormone receptor binding|transcription activator activity|vitamin D receptor binding			breast(2)|kidney(1)|skin(1)	4														0.210526	44.450644	51.813956	20	75	GG		KEEP	---	---	---	---	capture			Silent	SNP	40419495	40419495	9821	23	G	A	A	40	40	MED14	A	1	1
MTMR8	55613	broad.mit.edu	36	X	63405180	63405180	+	Missense_Mutation	SNP	C	T	T			TCGA-14-3477-01	TCGA-14-3477-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chrX:63405180C>T	uc004dvs.1	-	c.2077G>A	c.(2077-2079)GCC>ACC	p.A693T		NM_017677	NP_060147	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	693						nuclear envelope	protein tyrosine phosphatase activity			ovary(2)|breast(2)	4														0.155914	54.363774	75.382543	29	157	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	63405180	63405180	10342	23	C	T	T	26	26	MTMR8	T	2	2
ZC3H12B	340554	broad.mit.edu	36	X	64625552	64625552	+	Missense_Mutation	SNP	T	A	A			TCGA-14-3477-01	TCGA-14-3477-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chrX:64625552T>A	uc010nko.1	+	c.113T>A	c.(112-114)ATA>AAA	p.I38K		NM_001010888	NP_001010888	Q5HYM0	ZC12B_HUMAN	zinc finger CCCH-type containing 12B	38							endonuclease activity|nucleic acid binding|zinc ion binding			lung(1)|kidney(1)|pancreas(1)	3														0.131313	18.136247	31.196302	13	86	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	64625552	64625552	18150	23	T	A	A	49	49	ZC3H12B	A	4	4
THAP11	57215	broad.mit.edu	36	16	66434155	66434155	+	Frame_Shift_Del	DEL	A	-	-			TCGA-14-3477-01	TCGA-14-3477-01										Phase_I	Unspecified				Illumina GAIIx	g.chr16:66434155_66434155delA	uc002euo.1	+	c.197_197delA	c.(196-198)CAGfs	p.Q66fs	CENPT_uc002eun.2_Intron	NM_020457	NP_065190	Q96EK4	THA11_HUMAN	THAP domain containing 11	66	THAP-type.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|identical protein binding|metal ion binding				0		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00412)|Epithelial(162;0.018)|all cancers(182;0.118)										0.33			2	4				---	---	---	---	capture_indel			Frame_Shift_Del	DEL	66434155	66434155	16371	16	A	-	-	7	7	THAP11	-	5	5
COL8A2	1296	broad.mit.edu	36	1	36337292	36337292	+	Frame_Shift_Del	DEL	G	-	-			TCGA-14-3477-01	TCGA-14-3477-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:36337292_36337292delG	uc001bzv.1	-	c.577_577delC	c.(577-579)CAGfs	p.Q193fs	COL8A2_uc001bzw.1_Frame_Shift_Del_p.Q128fs	NM_005202	NP_005193	P25067	CO8A2_HUMAN	collagen, type VIII, alpha 2	193	Triple-helical region.				angiogenesis|cell-cell adhesion|extracellular matrix organization	basement membrane|collagen	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)												0.33			2	4				---	---	---	---	capture_indel			Frame_Shift_Del	DEL	36337292	36337292	3844	1	G	-	-	47	47	COL8A2	-	5	5
