Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	i_TCGAscape_Amplification_Peaks	i_TCGAscape_Deletion_Peaks	DrugBank	i_ACHILLES_Top_Genes	i_CCLE_ONCOMAP_overlapping_mutations	i_CCLE_ONCOMAP_total_mutations_in_gene	i_CCLE_SEQ_overlapping_mutations	i_CCLE_SEQ_total_mutations_in_gene	MUTSIG_Significant_Genes	OREGANNO_ID	OREGANNO_Values	i_tumor_f	i_init_t_lod	i_t_lod_fstar	i_t_alt_count	i_t_ref_count	i_normal_best_gt	i_failure_reasons	i_judgement	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	dataset	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	type	classification	start	end	gene	chr	ref_allele	tum_allele1	tum_allele2	context_orig	context65	gene_name	newbase	categ	categ_ignoring_null_categ
WDR11	55717	broad.mit.edu	36	10	122635335	122635335	+	Missense_Mutation	SNP	A	G	G			TCGA-16-1045-01	TCGA-16-1045-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr10:122635335A>G	uc009xzm.1	+	c.1868A>G	c.(1867-1869)AAC>AGC	p.N623S	WDR11_uc001lfd.1_Missense_Mutation_p.N141S|WDR11_uc009xzn.1_5'Flank	NM_018117	NP_060587	Q9BZH6	WDR11_HUMAN	bromodomain and WD repeat domain containing 2	623						integral to membrane					0														0.436275	305.636492	306.359343	89	115	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	122635335	122635335	17846	10	A	G	G	2	2	WDR11	G	4	4
PTEN	5728	broad.mit.edu	36	10	89710832	89710832	+	Nonsense_Mutation	SNP	C	T	T			TCGA-16-1045-01	TCGA-16-1045-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr10:89710832C>T	uc001kfb.1	+	c.1003C>T	c.(1003-1005)CGA>TGA	p.R335*		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	335	C2 tensin-type.			KANKDKANR->AAGADAANA: Reduces growth suppression activity and promotes anchorage-independent growth. Reduces binding to phospholipid membranes in vitro; phosphatase activity towards PtdIns(3,4,5)P3 is not affected.	apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of focal adhesion assembly|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of cyclin-dependent protein kinase activity|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R335*(21)|p.G165_*404del(1)|p.W274_F341del(1)|p.D326_K342del(1)|p.G165_K342del(1)		endometrium(831)|central_nervous_system(654)|skin(119)|haematopoietic_and_lymphoid_tissue(101)|prostate(97)|large_intestine(90)|breast(67)|lung(63)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(21)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(12)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2308		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)						31	p.R335*(SNU1040-Tumor)	264	TCGA GBM(2;<1E-8)|TSP Lung(26;0.18)			0.446809	205.212778	205.559553	63	78	CC		KEEP	---	---	---	---	capture	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)	Nonsense_Mutation	SNP	89710832	89710832	13192	10	C	T	T	23	23	PTEN	T	5	1
NAV2	89797	broad.mit.edu	36	11	20022106	20022106	+	Missense_Mutation	SNP	G	A	A			TCGA-16-1045-01	TCGA-16-1045-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr11:20022106G>A	uc009yhw.1	+	c.2980G>A	c.(2980-2982)GAT>AAT	p.D994N	NAV2_uc001mpp.1_Missense_Mutation_p.D907N|NAV2_uc001mpr.2_Missense_Mutation_p.D971N|NAV2_uc009yhx.1_Missense_Mutation_p.D57N|NAV2_uc009yhy.1_5'UTR	NM_182964	NP_892009	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 1	994						nucleus	ATP binding|helicase activity			ovary(1)|pancreas(1)	2														0.113636	19.065513	44.994972	20	156	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	20022106	20022106	10580	11	G	A	A	45	45	NAV2	A	2	2
OR51A2	401667	broad.mit.edu	36	11	4932722	4932722	+	Silent	SNP	G	A	A			TCGA-16-1045-01	TCGA-16-1045-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr11:4932722G>A	uc001lzu.1	-	c.798C>T	c.(796-798)GCC>GCT	p.A266A		NM_001004748	NP_001004748	Q8NGJ7	O51A2_HUMAN	olfactory receptor, family 51, subfamily A,	266	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)												0.163009	106.834645	141.230706	52	267	GG		KEEP	---	---	---	---	capture		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)	Silent	SNP	4932722	4932722	11496	11	G	A	A	39	39	OR51A2	A	1	1
OR10AG1	282770	broad.mit.edu	36	11	55491790	55491790	+	Missense_Mutation	SNP	G	T	T			TCGA-16-1045-01	TCGA-16-1045-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr11:55491790G>T	uc001nid.1	-	c.726C>A	c.(724-726)TTC>TTA	p.F242L		NM_001005491	NP_001005491	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG,	242	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(21;0.0137)													0.133333	18.881429	32.581007	14	91	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	55491790	55491790	11303	11	G	T	T	33	33	OR10AG1	T	3	3
TRIM5	85363	broad.mit.edu	36	11	5656214	5656214	+	Silent	SNP	G	A	A			TCGA-16-1045-01	TCGA-16-1045-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr11:5656214G>A	uc001mbm.1	-	c.540C>T	c.(538-540)AAC>AAT	p.N180N	TRIM5_uc001mbq.1_Silent_p.N180N|TRIM5_uc001mbl.1_Non-coding_Transcript|TRIM5_uc001mbn.1_Silent_p.N180N|TRIM5_uc001mbo.1_Silent_p.N180N|TRIM5_uc001mbp.1_Silent_p.N180N	NM_033034	NP_149023	Q9C035	TRIM5_HUMAN	tripartite motif protein TRIM5 isoform alpha	180	Potential.				interspecies interaction between organisms|protein trimerization|response to virus	cytoplasm|cytoplasmic mRNA processing body	ligase activity|protein binding|protein homodimerization activity|zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)|Lung NSC(207;0.138)|all_lung(207;0.221)												0.208696	107.165109	125.243451	48	182	GG		KEEP	---	---	---	---	capture		Epithelial(150;7.21e-09)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Silent	SNP	5656214	5656214	17071	11	G	A	A	40	40	TRIM5	A	1	1
GNPTAB	79158	broad.mit.edu	36	12	100682345	100682345	+	Silent	SNP	G	A	A	rs3751249	by-frequency,by-hapmap	TCGA-16-1045-01	TCGA-16-1045-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr12:100682345G>A	uc001tit.1	-	c.2481C>T	c.(2479-2481)GGC>GGT	p.G827G		NM_024312	NP_077288	Q3T906	GNPTA_HUMAN	N-acetylglucosamine-1-phosphate transferase	827					cell differentiation	Golgi membrane|integral to membrane|nucleus	metal ion binding|transcription factor binding|UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity			ovary(1)	1														0.29011	342.81686	360.780658	132	323	GG		KEEP	---	---	---	---	capture			Silent	SNP	100682345	100682345	6814	12	G	A	A	38	38	GNPTAB	A	1	1
SSH1	54434	broad.mit.edu	36	12	107736189	107736189	+	Missense_Mutation	SNP	T	A	A			TCGA-16-1045-01	TCGA-16-1045-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr12:107736189T>A	uc001tnm.1	-	c.244A>T	c.(244-246)ATC>TTC	p.I82F	SSH1_uc001tnn.2_Missense_Mutation_p.I82F|SSH1_uc001tno.1_5'Flank	NM_018984	NP_061857	Q8WYL5	SSH1_HUMAN	slingshot homolog 1	82					actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(4)	4														0.15748	76.640904	105.061753	40	214	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	107736189	107736189	15700	12	T	A	A	50	50	SSH1	A	4	4
CUX2	23316	broad.mit.edu	36	12	110256766	110256766	+	Missense_Mutation	SNP	C	T	T			TCGA-16-1045-01	TCGA-16-1045-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr12:110256766C>T	uc001tsa.1	+	c.3065C>T	c.(3064-3066)TCG>TTG	p.S1022L		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	1022						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|breast(1)	4														0.255556	57.872852	62.760212	23	67	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	110256766	110256766	4225	12	C	T	T	31	31	CUX2	T	1	1
DNAH10	196385	broad.mit.edu	36	12	122899233	122899233	+	Missense_Mutation	SNP	G	A	A			TCGA-16-1045-01	TCGA-16-1045-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr12:122899233G>A	uc001uft.2	+	c.5599G>A	c.(5599-5601)GTG>ATG	p.V1867M		NM_001083900	NP_001077369	Q8IVF4	DYH10_HUMAN	DNAH10 variant protein (Fragment).	1867	AAA 1 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|central_nervous_system(1)|skin(1)	5	all_neural(191;0.101)|Medulloblastoma(191;0.163)													0.202381	40.02943	46.9391	17	67	GG		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)	Missense_Mutation	SNP	122899233	122899233	4780	12	G	A	A	40	40	DNAH10	A	1	1
ZNF140	7699	broad.mit.edu	36	12	132193058	132193058	+	Silent	SNP	A	G	G			TCGA-16-1045-01	TCGA-16-1045-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr12:132193058A>G	uc001ulo.1	+	c.1122A>G	c.(1120-1122)CAA>CAG	p.Q374Q	ZNF140_uc001ulp.1_Silent_p.Q271Q	NM_003440	NP_003431	P52738	ZN140_HUMAN	zinc finger protein 140	374	C2H2-type 8.				regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.114)												0.318966	239.776341	246.528833	74	158	AA		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)	Silent	SNP	132193058	132193058	18320	12	A	G	G	2	2	ZNF140	G	4	4
GYS2	2998	broad.mit.edu	36	12	21624567	21624567	+	Silent	SNP	G	A	A			TCGA-16-1045-01	TCGA-16-1045-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr12:21624567G>A	uc001rfb.1	-	c.279C>T	c.(277-279)GAC>GAT	p.D93D		NM_021957	NP_068776	P54840	GYS2_HUMAN	glycogen synthase 2 (liver)	93					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity				0						Colon(149;9 1820 3690 10544 50424)								0.316265	297.764932	307.727681	105	227	GG		KEEP	---	---	---	---	capture			Silent	SNP	21624567	21624567	7193	12	G	A	A	40	40	GYS2	A	1	1
B4GALNT3	283358	broad.mit.edu	36	12	514593	514593	+	Missense_Mutation	SNP	G	A	A			TCGA-16-1045-01	TCGA-16-1045-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr12:514593G>A	uc001qii.1	+	c.170G>A	c.(169-171)AGG>AAG	p.R57K		NM_173593	NP_775864	Q6L9W6	B4GN3_HUMAN	beta	57	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity				0	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)													0.28169	54.381799	57.415293	20	51	GG		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)		Missense_Mutation	SNP	514593	514593	1289	12	G	A	A	43	43	B4GALNT3	A	2	2
VWF	7450	broad.mit.edu	36	12	5928548	5928548	+	Missense_Mutation	SNP	G	A	A			TCGA-16-1045-01	TCGA-16-1045-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr12:5928548G>A	uc001qnn.1	-	c.8336C>T	c.(8335-8337)ACG>ATG	p.T2779M	ANO2_uc001qnm.1_5'Flank	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	2779	CTCK.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			ovary(3)|pancreas(2)|breast(1)|central_nervous_system(1)	7					Antihemophilic Factor(DB00025)									0.155556	24.392494	34.591997	14	76	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	5928548	5928548	17818	12	G	A	A	40	40	VWF	A	1	1
ZFC3H1	196441	broad.mit.edu	36	12	70311889	70311889	+	Missense_Mutation	SNP	T	C	C			TCGA-16-1045-01	TCGA-16-1045-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr12:70311889T>C	uc001swo.1	-	c.3406A>G	c.(3406-3408)ATG>GTG	p.M1136V		NM_144982	NP_659419	O60293	ZC3H1_HUMAN	proline/serine-rich coiled-coil 2	1136					RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)	4														0.300926	205.998669	213.640084	65	151	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	70311889	70311889	18221	12	T	C	C	52	52	ZFC3H1	C	4	4
UNKL	64718	broad.mit.edu	36	16	1389392	1389392	+	Missense_Mutation	SNP	G	A	A			TCGA-16-1045-01	TCGA-16-1045-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr16:1389392G>A	uc010bro.1	-	c.718C>T	c.(718-720)CGG>TGG	p.R240W	UNKL_uc002clq.1_Missense_Mutation_p.R240W	NM_001037125	NP_001032202	Q9H9P5	UNKL_HUMAN	unkempt homolog (Drosophila)-like isoform 2	240						cytoplasm|nucleus	ligase activity|nucleic acid binding|zinc ion binding				0		Hepatocellular(780;0.0893)												0.190476	8.588477	10.468847	4	17	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	1389392	1389392	17560	16	G	A	A	39	39	UNKL	A	1	1
FBXO31	79791	broad.mit.edu	36	16	85926434	85926434	+	Missense_Mutation	SNP	G	A	A			TCGA-16-1045-01	TCGA-16-1045-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr16:85926434G>A	uc002fjw.1	-	c.973C>T	c.(973-975)CGT>TGT	p.R325C	FBXO31_uc002fjv.1_Missense_Mutation_p.R217C	NM_024735	NP_079011	Q5XUX0	FBX31_HUMAN	F-box protein 31	325					cell cycle|cyclin catabolic process|mitotic cell cycle G1/S transition DNA damage checkpoint|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	SCF ubiquitin ligase complex	cyclin binding			lung(1)	1														0.192308	39.683284	48.849208	20	84	GG		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(80;0.0272)	Missense_Mutation	SNP	85926434	85926434	5978	16	G	A	A	38	38	FBXO31	A	1	1
SLC6A4	6532	broad.mit.edu	36	17	25569328	25569328	+	Missense_Mutation	SNP	T	G	G			TCGA-16-1045-01	TCGA-16-1045-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr17:25569328T>G	uc002hey.2	-	c.632A>C	c.(631-633)AAT>ACT	p.N211T		NM_001045	NP_001036	P31645	SC6A4_HUMAN	solute carrier family 6 member 4	211	Extracellular (Potential).				response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|integral to plasma membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity			ovary(1)	1					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)									0.361345	135.155399	137.183649	43	76	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	25569328	25569328	15183	17	T	G	G	52	52	SLC6A4	G	4	4
OR1G1	8390	broad.mit.edu	36	17	2976671	2976671	+	Missense_Mutation	SNP	T	C	C			TCGA-16-1045-01	TCGA-16-1045-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr17:2976671T>C	uc002fvc.1	-	c.925A>G	c.(925-927)AAA>GAA	p.K309E		NM_003555	NP_003546	P47890	OR1G1_HUMAN	olfactory receptor, family 1, subfamily G,	309	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						Colon(127;1481 1654 8243 19426 50557)								0.381818	213.393675	215.411963	63	102	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	2976671	2976671	11363	17	T	C	C	62	62	OR1G1	C	4	4
TNS4	84951	broad.mit.edu	36	17	35905999	35905999	+	Missense_Mutation	SNP	C	T	T			TCGA-16-1045-01	TCGA-16-1045-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr17:35905999C>T	uc010cxb.1	-	c.205G>A	c.(205-207)GCC>ACC	p.A69T		NM_032865	NP_116254	Q8IZW8	TENS4_HUMAN	tensin 4	69					apoptosis|protein localization	cytoplasm|cytoskeleton|focal adhesion	actin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3		Breast(137;0.000496)												0.322034	163.439215	168.403919	57	120	CC		KEEP	---	---	---	---	capture	STAD - Stomach adenocarcinoma(5;5.91e-05)		Missense_Mutation	SNP	35905999	35905999	16886	17	C	T	T	28	28	TNS4	T	2	2
MRC2	9902	broad.mit.edu	36	17	58111981	58111981	+	Silent	SNP	G	A	A			TCGA-16-1045-01	TCGA-16-1045-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr17:58111981G>A	uc002jad.1	+	c.2562G>A	c.(2560-2562)ACG>ACA	p.T854T	MRC2_uc002jae.1_De_novo_Start_OutOfFrame|MRC2_uc002jaf.1_5'Flank	NM_006039	NP_006030	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	854	Extracellular (Potential).|C-type lectin 5.				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(1)|central_nervous_system(1)	2														0.372093	45.68792	46.306252	16	27	GG		KEEP	---	---	---	---	capture			Silent	SNP	58111981	58111981	10150	17	G	A	A	40	40	MRC2	A	1	1
ZNF521	25925	broad.mit.edu	36	18	21060839	21060839	+	Silent	SNP	G	A	A			TCGA-16-1045-01	TCGA-16-1045-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr18:21060839G>A	uc002kvk.1	-	c.1041C>T	c.(1039-1041)GTC>GTT	p.V347V	ZNF521_uc010dly.1_Silent_p.V347V|ZNF521_uc002kvl.1_Silent_p.V127V	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	347					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)									266				0.287671	110.788354	116.692595	42	104	GG		KEEP	---	---	---	---	capture			Silent	SNP	21060839	21060839	18559	18	G	A	A	45	45	ZNF521	A	2	2
SLC6A16	28968	broad.mit.edu	36	19	54504135	54504135	+	Missense_Mutation	SNP	A	T	T			TCGA-16-1045-01	TCGA-16-1045-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr19:54504135A>T	uc002pmz.1	-	c.1039T>A	c.(1039-1041)TTG>ATG	p.L347M	SLC6A16_uc002pna.2_Missense_Mutation_p.L347M	NM_014037	NP_054756	Q9GZN6	S6A16_HUMAN	solute carrier family 6, member 16	347	Helical; Name=6; (Potential).					integral to plasma membrane|intracellular	neurotransmitter:sodium symporter activity			ovary(1)|kidney(1)	2		all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)												0.303523	290.950161	303.66996	112	257	AA		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(262;0.00099)|GBM - Glioblastoma multiforme(486;0.0336)	Missense_Mutation	SNP	54504135	54504135	15176	19	A	T	T	1	1	SLC6A16	T	4	4
SIGLEC9	27180	broad.mit.edu	36	19	56322156	56322156	+	Missense_Mutation	SNP	G	A	A			TCGA-16-1045-01	TCGA-16-1045-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr19:56322156G>A	uc002pvu.1	+	c.806G>A	c.(805-807)CGC>CAC	p.R269H		NM_014441	NP_055256	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9	269	Extracellular (Potential).|Ig-like C2-type 2.			R -> H (in Ref. 2; AAF87223).	cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding				0		all_neural(266;0.0529)												0.269231	174.439387	186.933635	70	190	GG		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)	Missense_Mutation	SNP	56322156	56322156	14810	19	G	A	A	38	38	SIGLEC9	A	1	1
ZNF581	51545	broad.mit.edu	36	19	60847797	60847797	+	Silent	SNP	C	T	T			TCGA-16-1045-01	TCGA-16-1045-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr19:60847797C>T	uc002qln.1	+	c.48C>T	c.(46-48)TCC>TCT	p.S16S	ZNF581_uc002qlq.1_Silent_p.S16S|ZNF581_uc010etc.1_Silent_p.S16S|CCDC106_uc002qlr.1_5'Flank	NM_016535	NP_057619	Q9P0T4	ZN581_HUMAN	zinc finger protein 581	16					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(87;0.133)												0.388889	43.145114	43.53334	14	22	CC		KEEP	---	---	---	---	capture	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)	Silent	SNP	60847797	60847797	18608	19	C	T	T	23	23	ZNF581	T	1	1
FAM46C	54855	broad.mit.edu	36	1	117968100	117968100	+	Missense_Mutation	SNP	G	A	A			TCGA-16-1045-01	TCGA-16-1045-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:117968100G>A	uc001ehe.1	+	c.1087G>A	c.(1087-1089)GTC>ATC	p.V363I	FAM46C_uc009whh.1_Missense_Mutation_p.V363I	NM_017709	NP_060179	Q5VWP2	FA46C_HUMAN	hypothetical protein LOC54855	363											0	Lung SC(450;0.225)	all_cancers(81;0.000101)|all_lung(203;3.4e-06)|all_epithelial(167;4.98e-06)|Lung NSC(69;2.33e-05)									Multiple Myeloma(3;1.13e-06)			0.294118	40.505621	42.439878	15	36	GG		KEEP	---	---	---	---	capture		Lung(183;0.0576)|LUSC - Lung squamous cell carcinoma(189;0.192)|Colorectal(144;0.247)	Missense_Mutation	SNP	117968100	117968100	5788	1	G	A	A	40	40	FAM46C	A	1	1
DUSP27	92235	broad.mit.edu	36	1	165364167	165364167	+	Missense_Mutation	SNP	C	T	T			TCGA-16-1045-01	TCGA-16-1045-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:165364167C>T	uc001geb.1	+	c.3175C>T	c.(3175-3177)CGC>TGC	p.R1059C		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	1059					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3														0.230088	61.016831	68.546342	26	87	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	165364167	165364167	5009	1	C	T	T	27	27	DUSP27	T	1	1
GNB1	2782	broad.mit.edu	36	1	1714579	1714579	+	Missense_Mutation	SNP	G	T	T			TCGA-16-1045-01	TCGA-16-1045-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:1714579G>T	uc001aif.1	-	c.462C>A	c.(460-462)GAC>GAA	p.D154E	GNB1_uc009vky.1_Missense_Mutation_p.D54E	NM_002074	NP_002065	P62873	GBB1_HUMAN	guanine nucleotide-binding protein, beta-1	154	WD 3.				cellular response to glucagon stimulus|energy reserve metabolic process|muscarinic acetylcholine receptor signaling pathway|platelet activation|Ras protein signal transduction|synaptic transmission	heterotrimeric G-protein complex	GTPase activity|signal transducer activity				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.62e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)												0.12963	11.286681	18.496717	7	47	GG		KEEP	---	---	---	---	capture		Epithelial(90;1.14e-35)|OV - Ovarian serous cystadenocarcinoma(86;7.31e-23)|GBM - Glioblastoma multiforme(42;3.1e-07)|COAD - Colon adenocarcinoma(227;0.000323)|Colorectal(212;0.000374)|Kidney(185;0.00392)|BRCA - Breast invasive adenocarcinoma(365;0.00573)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.0482)|Lung(427;0.236)	Missense_Mutation	SNP	1714579	1714579	6784	1	G	T	T	48	48	GNB1	T	3	3
CEP350	9857	broad.mit.edu	36	1	178330113	178330113	+	Silent	SNP	A	G	G			TCGA-16-1045-01	TCGA-16-1045-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr1:178330113A>G	uc001gnt.1	+	c.8250A>G	c.(8248-8250)AAA>AAG	p.K2750K	CEP350_uc001gnv.1_Silent_p.K885K|CEP350_uc001gnw.1_Silent_p.K507K|CEP350_uc001gnx.1_Silent_p.K507K	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	2750	Potential.					centrosome|nucleus|spindle				ovary(4)	4														0.357143	86.257892	87.515266	25	45	AA		KEEP	---	---	---	---	capture			Silent	SNP	178330113	178330113	3387	1	A	G	G	1	1	CEP350	G	4	4
TPR	7175	broad.mit.edu	36	1	184595704	184595704	+	Silent	SNP	T	C	C			TCGA-16-1045-01	TCGA-16-1045-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr1:184595704T>C	uc001grv.1	-	c.1239A>G	c.(1237-1239)AAA>AAG	p.K413K	TPR_uc009wyn.1_Silent_p.K473K	NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	413					carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)								1949				0.296651	198.267948	205.996505	62	147	TT		KEEP	---	---	---	---	capture		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)	Silent	SNP	184595704	184595704	16960	1	T	C	C	60	60	TPR	C	4	4
PTPRC	5788	broad.mit.edu	36	1	196875082	196875082	+	Missense_Mutation	SNP	G	T	T			TCGA-16-1045-01	TCGA-16-1045-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:196875082G>T	uc001gur.1	+	c.55G>T	c.(55-57)GTA>TTA	p.V19L	PTPRC_uc001guq.1_Missense_Mutation_p.V19L|PTPRC_uc009wze.1_Missense_Mutation_p.V21L|PTPRC_uc009wzf.1_Missense_Mutation_p.V21L|PTPRC_uc001gus.1_Missense_Mutation_p.V19L|PTPRC_uc001gut.1_Missense_Mutation_p.V19L|PTPRC_uc001guu.1_Missense_Mutation_p.V21L|PTPRC_uc001guw.1_Non-coding_Transcript|PTPRC_uc001guv.1_Non-coding_Transcript	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	19					axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(2)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	11										815				0.087963	9.350298	46.439293	19	197	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	196875082	196875082	13254	1	G	T	T	36	36	PTPRC	T	3	3
ZP4	57829	broad.mit.edu	36	1	236119791	236119791	+	Silent	SNP	T	A	A			TCGA-16-1045-01	TCGA-16-1045-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr1:236119791T>A	uc001hym.1	-	c.399A>T	c.(397-399)CTA>CTT	p.L133L		NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	133	Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(1)	1	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)				NSCLC(166;160 2029 11600 18754 19936)								0.114754	76.648587	156.925381	63	486	TT		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Silent	SNP	236119791	236119791	18822	1	T	A	A	53	53	ZP4	A	4	4
DMBX1	127343	broad.mit.edu	36	1	46745365	46745365	+	Silent	SNP	G	A	A			TCGA-16-1045-01	TCGA-16-1045-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:46745365G>A	uc001cpx.1	+	c.96G>A	c.(94-96)CAG>CAA	p.Q32Q	DMBX1_uc001cpw.1_Silent_p.Q32Q	NM_147192	NP_671725	Q8NFW5	DMBX1_HUMAN	diencephalon/mesencephalon homeobox 1 isoform b	32	Interacts with OXT2 and is required for repressor activity (By similarity).				brain development|developmental growth|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription repressor activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)													0.346154	125.132779	127.850712	45	85	GG		KEEP	---	---	---	---	capture			Silent	SNP	46745365	46745365	4758	1	G	A	A	34	34	DMBX1	A	2	2
LRRC7	57554	broad.mit.edu	36	1	70250099	70250099	+	Missense_Mutation	SNP	T	C	C			TCGA-16-1045-01	TCGA-16-1045-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr1:70250099T>C	uc001dep.1	+	c.922T>C	c.(922-924)TGT>CGT	p.C308R	LRRC7_uc009wbg.1_5'UTR	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	308	LRR 13.					centrosome|focal adhesion|nucleolus	protein binding			ovary(8)|breast(2)|central_nervous_system(2)|liver(1)	13										783				0.29703	92.210449	95.930861	30	71	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	70250099	70250099	9396	1	T	C	C	55	55	LRRC7	C	4	4
SEC23B	10483	broad.mit.edu	36	20	18482935	18482935	+	Missense_Mutation	SNP	C	A	A			TCGA-16-1045-01	TCGA-16-1045-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr20:18482935C>A	uc002wqz.1	+	c.2049C>A	c.(2047-2049)TTC>TTA	p.F683L	SEC23B_uc002wra.1_Missense_Mutation_p.F683L|SEC23B_uc002wrb.1_Missense_Mutation_p.F683L|SEC23B_uc002wrc.1_Missense_Mutation_p.F683L	NM_006363	NP_116781	Q15437	SC23B_HUMAN	Sec23 homolog B	683					ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			ovary(1)	1														0.268156	120.815326	129.504864	48	131	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	18482935	18482935	14478	20	C	A	A	29	29	SEC23B	A	3	3
SLC9A8	23315	broad.mit.edu	36	20	47936785	47936785	+	Silent	SNP	C	T	T			TCGA-16-1045-01	TCGA-16-1045-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr20:47936785C>T	uc002xuv.1	+	c.1581C>T	c.(1579-1581)TTC>TTT	p.F527F	SLC9A8_uc010gid.1_Silent_p.F151F	NM_015266	NP_056081	Q9Y2E8	SL9A8_HUMAN	sodium/hydrogen exchanger 8	527						Golgi membrane|integral to membrane	sodium:hydrogen antiporter activity			ovary(1)	1														0.101266	13.322943	38.350642	16	142	CC		KEEP	---	---	---	---	capture	BRCA - Breast invasive adenocarcinoma(9;3.91e-07)		Silent	SNP	47936785	47936785	15217	20	C	T	T	31	31	SLC9A8	T	1	1
BRWD1	54014	broad.mit.edu	36	21	39493380	39493380	+	Nonsense_Mutation	SNP	G	T	T			TCGA-16-1045-01	TCGA-16-1045-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr21:39493380G>T	uc002yxk.1	-	c.4832C>A	c.(4831-4833)TCA>TAA	p.S1611*	BRWD1_uc002yxl.1_Nonsense_Mutation_p.S1611*|BRWD1_uc010goc.1_Nonsense_Mutation_p.S254*	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	1611					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(1)	1		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				Melanoma(170;988 1986 4794 16843 39731)						OREG0003861	type=REGULATORY REGION|Gene=BRWD1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	0.350394	248.787306	253.807852	89	165	GG		KEEP	---	---	---	---	capture			Nonsense_Mutation	SNP	39493380	39493380	1556	21	G	T	T	45	45	BRWD1	T	5	3
MEI1	150365	broad.mit.edu	36	22	40510635	40510635	+	Missense_Mutation	SNP	G	C	C	rs139541	unknown	TCGA-16-1045-01	TCGA-16-1045-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr22:40510635G>C	uc003baz.1	+	c.3247G>C	c.(3247-3249)GCC>CCC	p.A1083P	LOC339674_uc003bba.1_Intron|MEI1_uc003bbb.1_Missense_Mutation_p.A469P|MEI1_uc003bbc.1_Missense_Mutation_p.A451P|MEI1_uc010gym.1_Missense_Mutation_p.A416P|MEI1_uc003bbd.1_Missense_Mutation_p.A326P|MEI1_uc010gyn.1_Intron|MEI1_uc003bbe.1_Non-coding_Transcript|MEI1_uc010gyo.1_Intron|MEI1_uc003bbf.2_Missense_Mutation_p.A97P|MEI1_uc003bbg.2_Missense_Mutation_p.A97P	NM_152513	NP_689726	Q5TIA1	MEI1_HUMAN	meiosis defective 1	1083							binding			skin(1)	1														0.304348	12.153623	12.920995	7	16	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	40510635	40510635	9854	22	G	C	C	42	42	MEI1	C	3	3
KLF7	8609	broad.mit.edu	36	2	207697057	207697057	+	Missense_Mutation	SNP	G	A	A			TCGA-16-1045-01	TCGA-16-1045-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr2:207697057G>A	uc002vbz.1	-	c.419C>T	c.(418-420)TCG>TTG	p.S140L	KLF7_uc002vca.1_Missense_Mutation_p.S140L	NM_003709	NP_003700	O75840	KLF7_HUMAN	Kruppel-like factor 7 (ubiquitous)	140					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding				0														0.384615	154.611034	156.305213	55	88	GG		KEEP	---	---	---	---	capture		LUSC - Lung squamous cell carcinoma(261;0.0856)|Lung(261;0.166)|Epithelial(149;0.173)	Missense_Mutation	SNP	207697057	207697057	8663	2	G	A	A	37	37	KLF7	A	1	1
DOCK10	55619	broad.mit.edu	36	2	225374967	225374967	+	Nonsense_Mutation	SNP	G	A	A			TCGA-16-1045-01	TCGA-16-1045-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr2:225374967G>A	uc010fwz.1	-	c.4303C>T	c.(4303-4305)CAG>TAG	p.Q1435*	DOCK10_uc002vob.2_Nonsense_Mutation_p.Q1429*|DOCK10_uc002voc.1_5'Flank	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1435							GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)												0.301802	171.662038	179.437696	67	155	GG		KEEP	---	---	---	---	capture		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)	Nonsense_Mutation	SNP	225374967	225374967	4869	2	G	A	A	46	46	DOCK10	A	5	2
CAPN10	11132	broad.mit.edu	36	2	241205067	241205067	+	Silent	SNP	C	T	T			TCGA-16-1045-01	TCGA-16-1045-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr2:241205067C>T	uc002vzq.1	+	c.399C>T	c.(397-399)GCC>GCT	p.A133A	GPR35_uc010fzh.1_Intron|GPR35_uc010fzi.1_Intron	NM_023089	NP_075577	Q9HC96	CAN10_HUMAN	calpain 10 isoform g	Error:Variant_position_missing_in_Q9HC96_after_alignment					actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			ovary(3)|large_intestine(2)|lung(1)	6		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)												0.384615	29.749499	30.050866	10	16	CC		KEEP	---	---	---	---	capture		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)	Silent	SNP	241205067	241205067	2740	2	C	T	T	21	21	CAPN10	T	2	2
C2orf78	388960	broad.mit.edu	36	2	73897195	73897195	+	Silent	SNP	T	C	C			TCGA-16-1045-01	TCGA-16-1045-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr2:73897195T>C	uc002sjr.1	+	c.2337T>C	c.(2335-2337)GGT>GGC	p.G779G		NM_001080474	NP_001073943	A6NCI8	CB078_HUMAN	hypothetical protein LOC388960	779										ovary(2)	2														0.3	12.607141	13.718378	9	21	TT		KEEP	---	---	---	---	capture			Silent	SNP	73897195	73897195	2285	2	T	C	C	58	58	C2orf78	C	4	4
PHLDB2	90102	broad.mit.edu	36	3	113115166	113115166	+	Missense_Mutation	SNP	G	A	A			TCGA-16-1045-01	TCGA-16-1045-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr3:113115166G>A	uc010hqa.1	+	c.1646G>A	c.(1645-1647)CGG>CAG	p.R549Q	PHLDB2_uc003dyc.1_Missense_Mutation_p.R576Q|PHLDB2_uc003dyd.1_Missense_Mutation_p.R549Q|PHLDB2_uc003dyf.2_Missense_Mutation_p.R549Q|PHLDB2_uc003dyg.1_Missense_Mutation_p.R549Q|PHLDB2_uc003dyh.1_Missense_Mutation_p.R549Q|PHLDB2_uc003dyi.1_Missense_Mutation_p.R135Q	NM_145753	NP_665696	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	549						cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)	4														0.122137	89.108944	162.34262	64	460	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	113115166	113115166	12276	3	G	A	A	39	39	PHLDB2	A	1	1
PCCB	5096	broad.mit.edu	36	3	137463544	137463544	+	Missense_Mutation	SNP	G	A	A			TCGA-16-1045-01	TCGA-16-1045-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr3:137463544G>A	uc003eqz.1	+	c.490G>A	c.(490-492)GCA>ACA	p.A164T	PCCB_uc003eqy.1_Missense_Mutation_p.A164T	NM_000532	NP_000523	P05166	PCCB_HUMAN	propionyl Coenzyme A carboxylase, beta	164	Carboxyltransferase.				fatty acid beta-oxidation	mitochondrial matrix	ATP binding|propionyl-CoA carboxylase activity				0					Biotin(DB00121)|L-Valine(DB00161)									0.5	19.749795	19.749795	6	6	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	137463544	137463544	11925	3	G	A	A	34	34	PCCB	A	2	2
MECOM	2122	broad.mit.edu	36	3	170328523	170328523	+	Silent	SNP	G	A	A			TCGA-16-1045-01	TCGA-16-1045-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr3:170328523G>A	uc003ffl.2	-	c.549C>T	c.(547-549)TGC>TGT	p.C183C	MECOM_uc010hwn.1_Silent_p.C211C|MECOM_uc010hwk.1_Silent_p.C46C|MECOM_uc010hwl.1_Silent_p.C87C|MECOM_uc003ffi.2_Silent_p.C23C|MECOM_uc003ffj.2_Silent_p.C87C|MECOM_uc003ffn.2_Silent_p.C13C|MECOM_uc010hwm.1_Silent_p.C23C|MECOM_uc003ffk.2_Silent_p.C13C|MECOM_uc003ffm.1_Silent_p.C87C	NM_005241	NP_005232	Q13465	MDS1_HUMAN	ecotropic viral integration site 1 isoform b	Error:Variant_position_missing_in_Q13465_after_alignment							sequence-specific DNA binding transcription factor activity			lung(3)|skin(2)|ovary(1)|pancreas(1)|central_nervous_system(1)	8										646				0.316406	220.277923	227.954714	81	175	GG		KEEP	---	---	---	---	capture			Silent	SNP	170328523	170328523	9811	3	G	A	A	38	38	MECOM	A	1	1
MUC4	4585	broad.mit.edu	36	3	196984233	196984233	+	Missense_Mutation	SNP	C	T	T			TCGA-16-1045-01	TCGA-16-1045-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr3:196984233C>T	uc010hzt.1	-	c.12782G>A	c.(12781-12783)CGG>CAG	p.R4261Q	MUC4_uc003fvo.1_Missense_Mutation_p.R153Q|MUC4_uc003fvp.1_Missense_Mutation_p.R102Q|MUC4_uc010hzu.1_Missense_Mutation_p.R1001Q|MUC4_uc003fuz.1_Missense_Mutation_p.G69R|MUC4_uc003fva.1_5'UTR|MUC4_uc003fvb.1_5'UTR|MUC4_uc003fvd.1_Non-coding_Transcript|MUC4_uc003fve.1_5'UTR|MUC4_uc003fvc.1_Non-coding_Transcript|MUC4_uc010hzr.1_Non-coding_Transcript|MUC4_uc003fvm.1_5'UTR|MUC4_uc003fvg.1_5'UTR|MUC4_uc003fvf.1_Non-coding_Transcript|MUC4_uc003fvh.1_5'UTR|MUC4_uc010hzs.1_Missense_Mutation_p.R130Q|MUC4_uc003fvi.1_5'UTR|MUC4_uc003fvj.1_5'UTR|MUC4_uc003fvk.1_Missense_Mutation_p.R130Q|MUC4_uc003fvl.1_5'UTR	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	1146					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)												0.325581	122.945555	126.407145	42	87	CC		KEEP	---	---	---	---	capture	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)	Missense_Mutation	SNP	196984233	196984233	10372	3	C	T	T	23	23	MUC4	T	1	1
GADL1	339896	broad.mit.edu	36	3	30860743	30860743	+	Missense_Mutation	SNP	T	A	A			TCGA-16-1045-01	TCGA-16-1045-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr3:30860743T>A	uc003ceq.1	-	c.749A>T	c.(748-750)GAG>GTG	p.E250V	GADL1_uc003cep.1_Missense_Mutation_p.E66V	NM_207359	NP_997242	Q6ZQY3	GADL1_HUMAN	glutamate decarboxylase-like 1	250					carboxylic acid metabolic process		carboxy-lyase activity|pyridoxal phosphate binding				0					Pyridoxal Phosphate(DB00114)									0.320588	290.643013	300.372282	109	231	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	30860743	30860743	6436	3	T	A	A	54	54	GADL1	A	4	4
FLNB	2317	broad.mit.edu	36	3	58110736	58110736	+	Missense_Mutation	SNP	G	A	A			TCGA-16-1045-01	TCGA-16-1045-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr3:58110736G>A	uc010hne.1	+	c.6304G>A	c.(6304-6306)GTC>ATC	p.V2102I	FLNB_uc003djj.1_Missense_Mutation_p.V2071I|FLNB_uc003djk.1_Missense_Mutation_p.V2060I|FLNB_uc010hnf.1_Missense_Mutation_p.V2047I|FLNB_uc003djl.1_Missense_Mutation_p.V1891I|FLNB_uc003djm.1_Missense_Mutation_p.V1878I|FLNB_uc010hng.1_Non-coding_Transcript	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B, beta (actin binding protein 278)	2071	Interaction with FLNA 1.|Filamin 19.|Interaction with the cytoplasmic tail of GP1BA.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(6)|ovary(3)	9										676				0.106212	49.328729	126.083447	53	446	GG		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)	Missense_Mutation	SNP	58110736	58110736	6176	3	G	A	A	40	40	FLNB	A	1	1
TBC1D9	23158	broad.mit.edu	36	4	141764940	141764940	+	Silent	SNP	C	T	T			TCGA-16-1045-01	TCGA-16-1045-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr4:141764940C>T	uc010ioj.1	-	c.2952G>A	c.(2950-2952)ACG>ACA	p.T984T		NM_015130	NP_055945	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	984						intracellular	calcium ion binding|Rab GTPase activator activity			ovary(1)	1	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)												0.24359	51.805395	56.465932	19	59	CC		KEEP	---	---	---	---	capture			Silent	SNP	141764940	141764940	16153	4	C	T	T	23	23	TBC1D9	T	1	1
RPS3A	6189	broad.mit.edu	36	4	152243588	152243588	+	Missense_Mutation	SNP	A	C	C			TCGA-16-1045-01	TCGA-16-1045-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr4:152243588A>C	uc003ilz.1	+	c.470A>C	c.(469-471)CAG>CCG	p.Q157P	SNORD73A_uc003ima.1_5'Flank	NM_001006	NP_000997	P61247	RS3A_HUMAN	ribosomal protein S3a	157					cell differentiation|endocrine pancreas development|induction of apoptosis|translational elongation|translational initiation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome			ovary(1)	1	all_hematologic(180;0.093)													0.098592	6.670468	18.114582	7	64	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	152243588	152243588	14124	4	A	C	C	7	7	RPS3A	C	4	4
SLC10A4	201780	broad.mit.edu	36	4	48180873	48180873	+	Missense_Mutation	SNP	G	A	A			TCGA-16-1045-01	TCGA-16-1045-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr4:48180873G>A	uc003gyc.1	+	c.538G>A	c.(538-540)GGC>AGC	p.G180S		NM_152679	NP_689892	Q96EP9	NTCP4_HUMAN	solute carrier family 10 (sodium/bile acid	180	Helical; (Potential).					integral to membrane	bile acid:sodium symporter activity			central_nervous_system(1)	1														0.292683	33.48871	35.063585	12	29	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	48180873	48180873	14871	4	G	A	A	39	39	SLC10A4	A	1	1
YTHDC1	91746	broad.mit.edu	36	4	68867149	68867149	+	Nonsense_Mutation	SNP	C	A	A			TCGA-16-1045-01	TCGA-16-1045-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr4:68867149C>A	uc003hdx.1	-	c.1711G>T	c.(1711-1713)GAA>TAA	p.E571*	YTHDC1_uc003hdy.1_Nonsense_Mutation_p.E553*	NM_001031732	NP_001026902	Q96MU7	YTDC1_HUMAN	splicing factor YT521-B isoform 1	571	Arg-rich.									ovary(1)	1														0.282178	146.984694	155.598998	57	145	CC		KEEP	---	---	---	---	capture			Nonsense_Mutation	SNP	68867149	68867149	18079	4	C	A	A	30	30	YTHDC1	A	5	3
SLC6A18	348932	broad.mit.edu	36	5	1278635	1278635	+	Missense_Mutation	SNP	G	A	A			TCGA-16-1045-01	TCGA-16-1045-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr5:1278635G>A	uc003jby.1	+	c.43G>A	c.(43-45)GGG>AGG	p.G15R		NM_182632	NP_872438	Q96N87	S6A18_HUMAN	solute carrier family 6, member 18	15	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)													0.114286	7.374398	17.631842	8	62	GG		KEEP	---	---	---	---	capture	Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)		Missense_Mutation	SNP	1278635	1278635	15178	5	G	A	A	39	39	SLC6A18	A	1	1
PCDHA12	56137	broad.mit.edu	36	5	140237226	140237226	+	Missense_Mutation	SNP	C	T	T	rs73263833	by-1000genomes	TCGA-16-1045-01	TCGA-16-1045-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr5:140237226C>T	uc003lic.1	+	c.1985C>T	c.(1984-1986)ACG>ATG	p.T662M	PCDHA1_uc003lha.1_Intron|PCDHA1_uc003lhb.1_Intron|PCDHA2_uc003lhd.1_Intron|PCDHA3_uc003lhf.1_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA4_uc003lhi.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.1_Intron|PCDHA6_uc003lho.1_Intron|PCDHA6_uc003lhn.1_Intron|PCDHA7_uc003lhq.1_Intron|PCDHA8_uc003lhs.1_Intron|PCDHA9_uc003lhu.1_Intron|PCDHA10_uc003lhx.1_Intron|PCDHA10_uc003lhw.1_Intron|PCDHA11_uc003lia.1_Intron|PCDHA12_uc003lib.1_Missense_Mutation_p.T662M	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	662	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0						Pancreas(113;759 1672 13322 24104 50104)								0.304878	65.344357	68.129505	25	57	CC		KEEP	---	---	---	---	capture	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Missense_Mutation	SNP	140237226	140237226	11942	5	C	T	T	19	19	PCDHA12	T	1	1
EBF1	1879	broad.mit.edu	36	5	158455947	158455947	+	Missense_Mutation	SNP	G	T	T			TCGA-16-1045-01	TCGA-16-1045-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr5:158455947G>T	uc010jip.1	-	c.337C>A	c.(337-339)CAG>AAG	p.Q113K	EBF1_uc003lxl.2_Missense_Mutation_p.Q113K	NM_024007	NP_076870	Q9UH73	COE1_HUMAN	early B-cell factor	113					multicellular organismal development|regulation of transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|transcription regulator activity		HMGA2/EBF1(2)	soft_tissue(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)												0.358974	38.93664	39.620533	14	25	GG		KEEP	---	---	---	---	capture	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Missense_Mutation	SNP	158455947	158455947	5066	5	G	T	T	45	45	EBF1	T	3	3
WWC1	23286	broad.mit.edu	36	5	167774024	167774024	+	Silent	SNP	C	T	T	rs61730020	unknown	TCGA-16-1045-01	TCGA-16-1045-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr5:167774024C>T	uc003lzu.1	+	c.1035C>T	c.(1033-1035)AAC>AAT	p.N345N	WWC1_uc003lzv.1_Silent_p.N251N|WWC1_uc003lzw.1_Silent_p.N144N	NM_015238	NP_056053	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1	345	Potential.				cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			ovary(2)|breast(1)	3	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)												0.285714	15.643346	16.507495	6	15	CC		KEEP	---	---	---	---	capture	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)	Silent	SNP	167774024	167774024	17985	5	C	T	T	19	19	WWC1	T	1	1
LHFPL2	10184	broad.mit.edu	36	5	77820633	77820633	+	Missense_Mutation	SNP	C	T	T			TCGA-16-1045-01	TCGA-16-1045-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr5:77820633C>T	uc003kfo.1	-	c.530G>A	c.(529-531)GGA>GAA	p.G177E		NM_005779	NP_005770	Q6ZUX7	LHPL2_HUMAN	lipoma HMGIC fusion partner-like 2	177						integral to membrane					0		all_lung(232;0.000409)|Lung NSC(167;0.00108)|Ovarian(174;0.0107)|Prostate(461;0.218)												0.238318	123.526604	136.907135	51	163	CC		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(54;6.48e-46)|Epithelial(54;8.43e-42)|all cancers(79;1.42e-36)	Missense_Mutation	SNP	77820633	77820633	9091	5	C	T	T	30	30	LHFPL2	T	2	2
ARSK	153642	broad.mit.edu	36	5	94944452	94944452	+	Missense_Mutation	SNP	C	T	T			TCGA-16-1045-01	TCGA-16-1045-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr5:94944452C>T	uc003kld.1	+	c.493C>T	c.(493-495)CGT>TGT	p.R165C	ARSK_uc010jbg.1_Missense_Mutation_p.R6C	NM_198150	NP_937793	Q6UWY0	ARSK_HUMAN	arylsulfatase K	165						extracellular region	arylsulfatase activity|metal ion binding			pancreas(1)	1		all_cancers(142;3.38e-06)|all_epithelial(76;6.57e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)												0.105442	32.020989	77.493563	31	263	CC		KEEP	---	---	---	---	capture		all cancers(79;6.5e-16)	Missense_Mutation	SNP	94944452	94944452	1014	5	C	T	T	23	23	ARSK	T	1	1
TDP2	51567	broad.mit.edu	36	6	24774788	24774788	+	Missense_Mutation	SNP	C	T	T			TCGA-16-1045-01	TCGA-16-1045-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr6:24774788C>T	uc003nej.1	-	c.196G>A	c.(196-198)GTG>ATG	p.V66M	TDP2_uc003nei.1_De_novo_Start_InFrame|TDP2_uc010jpu.1_Missense_Mutation_p.V66M|ACOT13_uc003nek.1_5'Flank|ACOT13_uc010jpv.1_5'Flank	NM_016614	NP_057698	O95551	TYDP2_HUMAN	TRAF and TNF receptor-associated protein	66					cell surface receptor linked signaling pathway|double-strand break repair	PML body	5'-tyrosyl-DNA phosphodiesterase activity|magnesium ion binding|nuclease activity|protein binding|transcription corepressor activity			ovary(1)	1														0.257908	265.84582	287.691152	106	305	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	24774788	24774788	16255	6	C	T	T	18	18	TDP2	T	2	2
UHRF1BP1	54887	broad.mit.edu	36	6	34947642	34947642	+	Missense_Mutation	SNP	G	A	A			TCGA-16-1045-01	TCGA-16-1045-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr6:34947642G>A	uc003oju.2	+	c.4159G>A	c.(4159-4161)GTG>ATG	p.V1387M	UHRF1BP1_uc010jvm.1_Non-coding_Transcript|UHRF1BP1_uc010jvn.1_Non-coding_Transcript|UHRF1BP1_uc010jvo.1_Non-coding_Transcript	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	ICBP90 binding protein 1	1387										ovary(3)	3														0.368421	82.797844	83.947111	28	48	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	34947642	34947642	17526	6	G	A	A	44	44	UHRF1BP1	A	2	2
TREML4	285852	broad.mit.edu	36	6	41304153	41304153	+	Missense_Mutation	SNP	G	A	A			TCGA-16-1045-01	TCGA-16-1045-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr6:41304153G>A	uc003oqc.1	+	c.10G>A	c.(10-12)GGT>AGT	p.G4S	TREML4_uc003oqd.1_5'Flank	NM_198153	NP_937796	Q6UXN2	TRML4_HUMAN	triggering receptor expressed on myeloid	4						extracellular region				breast(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)													0.296296	19.476833	20.487491	8	19	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	41304153	41304153	17018	6	G	A	A	43	43	TREML4	A	2	2
LRCH4	4034	broad.mit.edu	36	7	100013784	100013784	+	Silent	SNP	G	A	A			TCGA-16-1045-01	TCGA-16-1045-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr7:100013784G>A	uc003uvj.1	-	c.882C>T	c.(880-882)TAC>TAT	p.Y294Y	LRCH4_uc010lgz.1_Non-coding_Transcript|LRCH4_uc003uvi.1_Non-coding_Transcript	NM_002319	NP_002310	O75427	LRCH4_HUMAN	leucine-rich repeats and calponin homology (CH)	294					nervous system development	PML body	protein binding			large_intestine(1)|ovary(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)													0.114943	11.091662	23.79866	10	77	GG		KEEP	---	---	---	---	capture			Silent	SNP	100013784	100013784	9308	7	G	A	A	40	40	LRCH4	A	1	1
ELMO1	9844	broad.mit.edu	36	7	37139336	37139336	+	Missense_Mutation	SNP	G	A	A			TCGA-16-1045-01	TCGA-16-1045-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr7:37139336G>A	uc003tfk.1	-	c.1115C>T	c.(1114-1116)ACG>ATG	p.T372M	ELMO1_uc010kxg.1_Missense_Mutation_p.T372M	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	372	ELMO.				actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)	3														0.253968	78.634681	85.562001	32	94	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	37139336	37139336	5257	7	G	A	A	40	40	ELMO1	A	1	1
DDC	1644	broad.mit.edu	36	7	50564419	50564419	+	Missense_Mutation	SNP	A	G	G			TCGA-16-1045-01	TCGA-16-1045-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr7:50564419A>G	uc003tpf.2	-	c.551T>C	c.(550-552)GTG>GCG	p.V184A	DDC_uc003tpg.2_Missense_Mutation_p.V184A|DDC_uc010kza.1_Intron	NM_000790	NP_001076440	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid	184					cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(2)	2	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)									0.233216	151.486622	169.954379	66	217	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	50564419	50564419	4496	7	A	G	G	6	6	DDC	G	4	4
CACNA2D1	781	broad.mit.edu	36	7	81426982	81426982	+	Silent	SNP	C	T	T			TCGA-16-1045-01	TCGA-16-1045-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr7:81426982C>T	uc003uhr.1	-	c.3066G>A	c.(3064-3066)GCG>GCA	p.A1022A		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	1034	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)									0.447761	201.695583	202.012206	60	74	CC		KEEP	---	---	---	---	capture			Silent	SNP	81426982	81426982	2664	7	C	T	T	23	23	CACNA2D1	T	1	1
PON1	5444	broad.mit.edu	36	7	94775360	94775360	+	Silent	SNP	A	T	T			TCGA-16-1045-01	TCGA-16-1045-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr7:94775360A>T	uc003uns.1	-	c.597T>A	c.(595-597)GGT>GGA	p.G199G		NM_000446	NP_000437	P27169	PON1_HUMAN	paraoxonase 1 precursor	199					aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			pancreas(1)	1	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)				Atorvastatin(DB01076)|Cefazolin(DB01327)	GBM(119;715 1622 17358 22490 33240)								0.146119	52.859204	79.222492	32	187	AA		KEEP	---	---	---	---	capture	STAD - Stomach adenocarcinoma(171;0.0031)		Silent	SNP	94775360	94775360	12677	7	A	T	T	2	2	PON1	T	4	4
CPSF1	29894	broad.mit.edu	36	8	145594631	145594631	+	Missense_Mutation	SNP	G	A	A			TCGA-16-1045-01	TCGA-16-1045-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr8:145594631G>A	uc003zcj.1	-	c.1763C>T	c.(1762-1764)ACG>ATG	p.T588M		NM_013291	NP_037423	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1,	588					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)					NSCLC(133;1088 1848 27708 34777 35269)								0.106897	25.208269	69.697297	31	259	GG		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)		Missense_Mutation	SNP	145594631	145594631	3962	8	G	A	A	40	40	CPSF1	A	1	1
LRRC14	9684	broad.mit.edu	36	8	145716135	145716135	+	Missense_Mutation	SNP	G	A	A			TCGA-16-1045-01	TCGA-16-1045-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr8:145716135G>A	uc003zdk.1	+	c.218G>A	c.(217-219)CGT>CAT	p.R73H	RECQL4_uc003zdj.1_5'Flank|LRRC14_uc003zdl.1_Missense_Mutation_p.R73H|LRRC14_uc003zdo.1_5'Flank	NM_014665	NP_055480	Q15048	LRC14_HUMAN	leucine rich repeat containing 14	73											0	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)													0.140127	31.855131	51.487403	22	135	GG		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)		Missense_Mutation	SNP	145716135	145716135	9342	8	G	A	A	40	40	LRRC14	A	1	1
FAM122A	116224	broad.mit.edu	36	9	70585550	70585550	+	Missense_Mutation	SNP	T	C	C			TCGA-16-1045-01	TCGA-16-1045-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr9:70585550T>C	uc004agw.1	+	c.650T>C	c.(649-651)TTT>TCT	p.F217S	PIP5K1B_uc004agu.1_Intron|PIP5K1B_uc004agv.1_Intron	NM_138333	NP_612206	Q96E09	F122A_HUMAN	hypothetical protein LOC116224	217											0														0.441026	298.221925	298.812791	86	109	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	70585550	70585550	5616	9	T	C	C	64	64	FAM122A	C	4	4
NFIL3	4783	broad.mit.edu	36	9	93212093	93212093	+	Missense_Mutation	SNP	C	T	T			TCGA-16-1045-01	TCGA-16-1045-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr9:93212093C>T	uc004arh.1	-	c.745G>A	c.(745-747)GGG>AGG	p.G249R	NFIL3_uc010mqq.1_Missense_Mutation_p.G249R	NM_005384	NP_005375	Q16649	NFIL3_HUMAN	nuclear factor, interleukin 3 regulated	249					circadian rhythm|immune response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulator activity				0						Esophageal Squamous(152;732 1832 10053 26981 51762)								0.415385	247.535932	248.755976	81	114	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	93212093	93212093	10773	9	C	T	T	22	22	NFIL3	T	2	2
DRP2	1821	broad.mit.edu	36	X	100397785	100397785	+	Missense_Mutation	SNP	C	T	T			TCGA-16-1045-01	TCGA-16-1045-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chrX:100397785C>T	uc004egz.2	+	c.2269C>T	c.(2269-2271)CGG>TGG	p.R757W		NM_001939	NP_001930	Q13474	DRP2_HUMAN	dystrophin related protein 2	757					central nervous system development	cytoplasm|cytoskeleton	zinc ion binding			ovary(2)	2														0.207447	82.316016	97.236988	39	149	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	100397785	100397785	4948	23	C	T	T	27	27	DRP2	T	1	1
LONRF3	79836	broad.mit.edu	36	X	118029876	118029876	+	Missense_Mutation	SNP	T	A	A			TCGA-16-1045-01	TCGA-16-1045-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chrX:118029876T>A	uc004eqw.1	+	c.1723T>A	c.(1723-1725)TTT>ATT	p.F575I	LONRF3_uc004eqx.1_Missense_Mutation_p.F534I|LONRF3_uc004eqy.1_Non-coding_Transcript|LONRF3_uc004eqz.1_Missense_Mutation_p.F319I	NM_001031855	NP_001027026	Q496Y0	LONF3_HUMAN	LON peptidase N-terminal domain and ring finger	575	Lon.				proteolysis		ATP-dependent peptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)	2														0.267606	294.260294	315.036376	114	312	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	118029876	118029876	9268	23	T	A	A	56	56	LONRF3	A	4	4
FAM70A	55026	broad.mit.edu	36	X	119294794	119294794	+	Missense_Mutation	SNP	C	T	T			TCGA-16-1045-01	TCGA-16-1045-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chrX:119294794C>T	uc004eso.2	-	c.721G>A	c.(721-723)GCT>ACT	p.A241T	FAM70A_uc004esp.2_Missense_Mutation_p.A217T|FAM70A_uc010nqo.1_Intron	NM_017938	NP_060408	Q5JRV8	FA70A_HUMAN	hypothetical protein LOC55026 isoform 1	241	Helical; (Potential).					integral to membrane				lung(1)|breast(1)	2														0.268293	166.178045	178.07815	66	180	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	119294794	119294794	5828	23	C	T	T	27	27	FAM70A	T	1	1
GLUD2	2747	broad.mit.edu	36	X	120009651	120009651	+	Silent	SNP	G	A	A			TCGA-16-1045-01	TCGA-16-1045-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chrX:120009651G>A	uc004eto.1	+	c.432G>A	c.(430-432)ACG>ACA	p.T144T		NM_012084	NP_036216	P49448	DHE4_HUMAN	glutamate dehydrogenase 2	144					glutamate biosynthetic process|glutamate catabolic process|oxidation-reduction process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			pancreas(1)	1					L-Glutamic Acid(DB00142)|NADH(DB00157)									0.213793	65.609303	76.55816	31	114	GG		KEEP	---	---	---	---	capture			Silent	SNP	120009651	120009651	6745	23	G	A	A	38	38	GLUD2	A	1	1
OCRL	4952	broad.mit.edu	36	X	128529007	128529007	+	Missense_Mutation	SNP	C	A	A			TCGA-16-1045-01	TCGA-16-1045-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chrX:128529007C>A	uc004euq.1	+	c.1452C>A	c.(1450-1452)GAC>GAA	p.D484E	OCRL_uc004eur.1_Missense_Mutation_p.D484E	NM_000276	NP_000267	Q01968	OCRL_HUMAN	phosphatidylinositol polyphosphate 5-phosphatase	484					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome|Golgi stack|Golgi-associated vesicle	GTPase activator activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity			lung(2)|ovary(1)|kidney(1)	4														0.120968	18.82991	36.214232	15	109	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	128529007	128529007	11228	23	C	A	A	18	18	OCRL	A	3	3
XPNPEP2	7512	broad.mit.edu	36	X	128714905	128714905	+	Silent	SNP	C	T	T			TCGA-16-1045-01	TCGA-16-1045-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chrX:128714905C>T	uc004eut.1	+	c.1107C>T	c.(1105-1107)CAC>CAT	p.H369H		NM_003399	NP_003390	O43895	XPP2_HUMAN	X-prolyl aminopeptidase 2, membrane-bound	369					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0														0.126126	40.172684	70.438401	28	194	CC		KEEP	---	---	---	---	capture			Silent	SNP	128714905	128714905	18026	23	C	T	T	19	19	XPNPEP2	T	1	1
SAGE1	55511	broad.mit.edu	36	X	134817204	134817204	+	Missense_Mutation	SNP	T	G	G			TCGA-16-1045-01	TCGA-16-1045-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chrX:134817204T>G	uc004ezh.1	+	c.944T>G	c.(943-945)GTA>GGA	p.V315G	SAGE1_uc010nry.1_Missense_Mutation_p.V284G	NM_018666	NP_061136	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	315										ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)													0.212366	221.645811	250.070534	79	293	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	134817204	134817204	14289	23	T	G	G	57	57	SAGE1	G	4	4
HUWE1	10075	broad.mit.edu	36	X	53628735	53628735	+	Nonsense_Mutation	SNP	G	A	A			TCGA-16-1045-01	TCGA-16-1045-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chrX:53628735G>A	uc004dso.1	-	c.4963C>T	c.(4963-4965)CGA>TGA	p.R1655*	HUWE1_uc004dsn.1_Nonsense_Mutation_p.R480*|HUWE1_uc004dsp.1_Nonsense_Mutation_p.R1655*	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	1655	WWE.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17														0.27551	384.939382	407.157169	135	355	GG		KEEP	---	---	---	---	capture			Nonsense_Mutation	SNP	53628735	53628735	7761	23	G	A	A	39	39	HUWE1	A	5	1
PAGE2B	389860	broad.mit.edu	36	X	55119822	55119822	+	Silent	SNP	A	C	C			TCGA-16-1045-01	TCGA-16-1045-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chrX:55119822A>C	uc004due.1	+	c.180A>C	c.(178-180)GCA>GCC	p.A60A		NM_001015038	NP_001015038	Q5JRK9	GGEE3_HUMAN	P antigen family, member 2B	60											0														0.333333	7.825828	8.329577	6	12	AA		KEEP	---	---	---	---	capture			Silent	SNP	55119822	55119822	11807	23	A	C	C	6	6	PAGE2B	C	4	4
OGT	8473	broad.mit.edu	36	X	70694232	70694232	+	Missense_Mutation	SNP	C	A	A			TCGA-16-1045-01	TCGA-16-1045-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chrX:70694232C>A	uc004eaa.1	+	c.1587C>A	c.(1585-1587)AAC>AAA	p.N529K	OGT_uc004eab.1_Missense_Mutation_p.N519K|OGT_uc004eac.2_Missense_Mutation_p.N390K|OGT_uc004ead.2_Missense_Mutation_p.N148K	NM_181672	NP_858058	O15294	OGT1_HUMAN	O-linked GlcNAc transferase isoform 1	529					cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			ovary(3)|kidney(1)|pancreas(1)	5	Renal(35;0.156)													0.289017	134.582541	141.484014	50	123	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	70694232	70694232	11252	23	C	A	A	18	18	OGT	A	3	3
TTN	7273	broad.mit.edu	36	2	179208669	179208669	+	Frame_Shift_Del	DEL	A	-	-			TCGA-16-1045-01	TCGA-16-1045-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:179208669_179208669delA	uc002umr.1	-	c.33923_33923delT	c.(33922-33924)CTGfs	p.L11308fs	TTN_uc002ums.1_Frame_Shift_Del_p.L5003fs|TTN_uc010frc.1_Frame_Shift_Del_p.L4936fs|TTN_uc010frd.1_Frame_Shift_Del_p.L4811fs	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12235										ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)							8722				0.35			15	28				---	---	---	---	capture_indel			Frame_Shift_Del	DEL	179208669	179208669	17290	2	A	-	-	7	7	TTN	-	5	5
PRIM2	5558	broad.mit.edu	36	6	57620875	57620876	+	Splice_Site_Ins	INS	-	T	T			TCGA-16-1045-01	TCGA-16-1045-01										Phase_I	Unspecified				Illumina GAIIx	g.chr6:57620875_57620876insT	uc003pdx.1	+	c.e16_splice_site				NM_000947	NP_000938			DNA primase polypeptide 2						DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)										0.33			6	12				---	---	---	---	capture_indel			Splice_Site_Ins	INS	57620875	57620876	12934	6	-	T	T	4	4	PRIM2	T	5	5
