Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	i_TCGAscape_Amplification_Peaks	i_TCGAscape_Deletion_Peaks	DrugBank	i_ACHILLES_Top_Genes	i_CCLE_ONCOMAP_overlapping_mutations	i_CCLE_ONCOMAP_total_mutations_in_gene	i_CCLE_SEQ_overlapping_mutations	i_CCLE_SEQ_total_mutations_in_gene	MUTSIG_Significant_Genes	OREGANNO_ID	OREGANNO_Values	i_tumor_f	i_init_t_lod	i_t_lod_fstar	i_t_alt_count	i_t_ref_count	i_normal_best_gt	i_failure_reasons	i_judgement	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	dataset	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	type	classification	start	end	gene	chr	ref_allele	tum_allele1	tum_allele2	context_orig	context65	gene_name	newbase	categ	categ_ignoring_null_categ
ADAM8	101	broad.mit.edu	36	10	134934457	134934457	+	Silent	SNP	G	A	A			TCGA-19-2624-01	TCGA-19-2624-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr10:134934457G>A	uc001lme.1	-	c.1482C>T	c.(1480-1482)AAC>AAT	p.N494N	ADAM8_uc009ybi.1_Silent_p.N494N	NM_001109	NP_001100	Q14C66	Q14C66_HUMAN	ADAM metallopeptidase domain 8 precursor	494					integrin-mediated signaling pathway|proteolysis		metalloendopeptidase activity|zinc ion binding			large_intestine(2)	2		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)												0.380952	45.895511	46.415417	16	26	GG		KEEP	---	---	---	---	capture		all cancers(32;7.72e-06)|OV - Ovarian serous cystadenocarcinoma(35;8.23e-06)|Epithelial(32;1.02e-05)	Silent	SNP	134934457	134934457	253	10	G	A	A	40	40	ADAM8	A	1	1
ALDH18A1	5832	broad.mit.edu	36	10	97386846	97386846	+	Silent	SNP	A	T	T			TCGA-19-2624-01	TCGA-19-2624-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr10:97386846A>T	uc001kkz.1	-	c.552T>A	c.(550-552)GCT>GCA	p.A184A	ALDH18A1_uc001kky.1_Silent_p.A184A	NM_002860	NP_002851	P54886	P5CS_HUMAN	pyrroline-5-carboxylate synthetase isoform 1	184	Glutamate 5-kinase.				oxidation-reduction process|proline biosynthetic process	mitochondrial inner membrane	ATP binding|glutamate 5-kinase activity|glutamate-5-semialdehyde dehydrogenase activity			central_nervous_system(1)|pancreas(1)	2		Colorectal(252;0.0402)			L-Glutamic Acid(DB00142)									0.74	129.695198	132.302006	37	13	AA		KEEP	---	---	---	---	capture		Epithelial(162;9.1e-07)|all cancers(201;2.55e-05)	Silent	SNP	97386846	97386846	492	10	A	T	T	7	7	ALDH18A1	T	4	4
FOXRED1	55572	broad.mit.edu	36	11	125651501	125651501	+	Missense_Mutation	SNP	A	G	G			TCGA-19-2624-01	TCGA-19-2624-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr11:125651501A>G	uc001qdi.1	+	c.974A>G	c.(973-975)TAT>TGT	p.Y325C	FOXRED1_uc001qdj.1_Missense_Mutation_p.Y114C|FOXRED1_uc001qdk.1_Missense_Mutation_p.Y114C	NM_017547	NP_060017	Q96CU9	FXRD1_HUMAN	FAD-dependent oxidoreductase domain containing	325					oxidation-reduction process	integral to membrane|mitochondrion	oxidoreductase activity|protein binding				0	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0739)|all_lung(97;0.0798)|all_neural(223;0.224)												0.125	8.525353	18.422494	9	63	AA		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0729)	Missense_Mutation	SNP	125651501	125651501	6279	11	A	G	G	16	16	FOXRED1	G	4	4
ST14	6768	broad.mit.edu	36	11	129575067	129575067	+	Missense_Mutation	SNP	C	T	T			TCGA-19-2624-01	TCGA-19-2624-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr11:129575067C>T	uc001qfw.1	+	c.1819C>T	c.(1819-1821)CGG>TGG	p.R607W		NM_021978	NP_068813	Q9Y5Y6	ST14_HUMAN	suppression of tumorigenicity 14	607	Extracellular (Potential).				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_hematologic(175;0.0429)	Lung NSC(97;0.000602)|Breast(109;0.000962)|all_lung(97;0.00126)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)			Urokinase(DB00013)									0.146341	30.680395	45.457659	18	105	CC		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(99;0.0183)|Lung(977;0.228)	Missense_Mutation	SNP	129575067	129575067	15729	11	C	T	T	27	27	ST14	T	1	1
OR51E2	81285	broad.mit.edu	36	11	4659703	4659703	+	Missense_Mutation	SNP	C	T	T			TCGA-19-2624-01	TCGA-19-2624-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr11:4659703C>T	uc001lzk.1	-	c.815G>A	c.(814-816)CGT>CAT	p.R272H	OR51E2_uc009yel.1_Missense_Mutation_p.R272H	NM_030774	NP_110401	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E,	272	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)												0.14433	22.119899	33.904193	14	83	CC		KEEP	---	---	---	---	capture		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)	Missense_Mutation	SNP	4659703	4659703	11505	11	C	T	T	19	19	OR51E2	T	1	1
C11orf35	256329	broad.mit.edu	36	11	548885	548885	+	Silent	SNP	G	A	A			TCGA-19-2624-01	TCGA-19-2624-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr11:548885G>A	uc001lpx.1	-	c.129C>T	c.(127-129)CCC>CCT	p.P43P	RASSF7_uc001lqa.1_5'Flank|RASSF7_uc001lqb.1_5'Flank|RASSF7_uc001lqc.1_5'Flank|RASSF7_uc001lqd.1_5'Flank	NM_173573	NP_775844	Q8IXW0	CK035_HUMAN	hypothetical protein LOC256329	43										pancreas(1)	1		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)												0.347826	62.15811	63.577668	24	45	GG		KEEP	---	---	---	---	capture		all cancers(45;7.18e-28)|Epithelial(43;6.93e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.97e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Silent	SNP	548885	548885	1677	11	G	A	A	39	39	C11orf35	A	1	1
OR8I2	120586	broad.mit.edu	36	11	55617875	55617875	+	Missense_Mutation	SNP	C	A	A			TCGA-19-2624-01	TCGA-19-2624-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr11:55617875C>A	uc001nig.1	+	c.516C>A	c.(514-516)AGC>AGA	p.S172R		NM_001003750	NP_001003750	Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I,	172	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1	Esophageal squamous(21;0.00693)													0.41704	283.935567	285.275529	93	130	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	55617875	55617875	11651	11	C	A	A	25	25	OR8I2	A	3	3
OR52N4	390072	broad.mit.edu	36	11	5733340	5733340	+	Missense_Mutation	SNP	G	A	A			TCGA-19-2624-01	TCGA-19-2624-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr11:5733340G>A	uc001mbu.1	+	c.794G>A	c.(793-795)CGC>CAC	p.R265H	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001005175	NP_001005175	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N,	265	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)												0.428571	264.857495	265.817748	93	124	GG		KEEP	---	---	---	---	capture		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)	Missense_Mutation	SNP	5733340	5733340	11539	11	G	A	A	38	38	OR52N4	A	1	1
ATXN2	6311	broad.mit.edu	36	12	110379439	110379439	+	Nonsense_Mutation	SNP	G	A	A			TCGA-19-2624-01	TCGA-19-2624-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr12:110379439G>A	uc001tsj.1	-	c.3478C>T	c.(3478-3480)CAA>TAA	p.Q1160*	ATXN2_uc001tsh.1_Nonsense_Mutation_p.Q895*|ATXN2_uc001tsi.1_Nonsense_Mutation_p.Q853*|ATXN2_uc001tsk.1_Non-coding_Transcript|ATXN2_uc001tsg.1_Nonsense_Mutation_p.Q348*|ATXN2_uc001tsl.1_Nonsense_Mutation_p.Q161*	NM_002973	NP_002964	Q99700	ATX2_HUMAN	ataxin 2	1160					cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			ovary(1)|breast(1)	2														0.5	99.694872	99.694872	32	32	GG		KEEP	---	---	---	---	capture			Nonsense_Mutation	SNP	110379439	110379439	1231	12	G	A	A	47	47	ATXN2	A	5	2
FZD10	11211	broad.mit.edu	36	12	129214618	129214618	+	Missense_Mutation	SNP	C	T	T			TCGA-19-2624-01	TCGA-19-2624-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr12:129214618C>T	uc001uii.1	+	c.1178C>T	c.(1177-1179)GCG>GTG	p.A393V		NM_007197	NP_009128	Q9ULW2	FZD10_HUMAN	frizzled 10	393	Extracellular (Potential).				brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|regulation of gene-specific transcription from RNA polymerase II promoter|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)													0.380435	99.015874	100.16431	35	57	CC		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)	Missense_Mutation	SNP	129214618	129214618	6380	12	C	T	T	27	27	FZD10	T	1	1
ESPL1	9700	broad.mit.edu	36	12	51949209	51949209	+	Silent	SNP	G	A	A			TCGA-19-2624-01	TCGA-19-2624-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr12:51949209G>A	uc001sck.2	+	c.216G>A	c.(214-216)GGG>GGA	p.G72G	ESPL1_uc001scj.2_5'UTR	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	extra spindle poles like 1	72					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)	2						Colon(53;1069 1201 2587 5382)								0.360294	136.959566	139.286077	49	87	GG		KEEP	---	---	---	---	capture			Silent	SNP	51949209	51949209	5446	12	G	A	A	41	41	ESPL1	A	2	2
TAC3	6866	broad.mit.edu	36	12	55692786	55692786	+	Missense_Mutation	SNP	C	T	T			TCGA-19-2624-01	TCGA-19-2624-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr12:55692786C>T	uc001smn.1	-	c.295G>A	c.(295-297)GGA>AGA	p.G99R	TAC3_uc001smm.1_Intron|TAC3_uc001smo.1_Intron|TAC3_uc001smp.1_Intron|TAC3_uc001smq.1_Non-coding_Transcript|TAC3_uc001smr.1_Intron|TAC3_uc001sms.1_Non-coding_Transcript|TAC3_uc001smt.1_Intron|TAC3_uc001smu.1_Intron|TAC3_uc001smv.1_Intron	NM_001006667	NP_001006668	Q9UHF0	TKNK_HUMAN	Tachykinin-3 precursor (ZNEUROK1) [Contains: Neurokinin-B (NKB) (Neuromedin-K)].	99					female pregnancy|neuropeptide signaling pathway|tachykinin receptor signaling pathway	extracellular space|soluble fraction	receptor binding			ovary(1)	1														0.714286	122.345217	124.363773	35	14	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	55692786	55692786	16020	12	C	T	T	22	22	TAC3	T	2	2
FOXJ2	55810	broad.mit.edu	36	12	8092604	8092604	+	Missense_Mutation	SNP	A	G	G			TCGA-19-2624-01	TCGA-19-2624-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr12:8092604A>G	uc001qtu.1	+	c.1270A>G	c.(1270-1272)AGC>GGC	p.S424G	FOXJ2_uc001qtt.1_Missense_Mutation_p.S424G	NM_018416	NP_060886	Q9P0K8	FOXJ2_HUMAN	forkhead box J2	424					embryo development|negative regulation of gene-specific transcription from RNA polymerase II promoter|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	nucleolus|nucleus|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|skin(1)	3														0.411371	427.86676	429.919323	123	176	AA		KEEP	---	---	---	---	capture		Kidney(36;0.0944)	Missense_Mutation	SNP	8092604	8092604	6258	12	A	G	G	3	3	FOXJ2	G	4	4
NEDD1	121441	broad.mit.edu	36	12	95869878	95869878	+	Silent	SNP	G	A	A			TCGA-19-2624-01	TCGA-19-2624-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr12:95869878G>A	uc001teu.2	+	c.1899G>A	c.(1897-1899)CTG>CTA	p.L633L	NEDD1_uc001tev.2_Silent_p.L633L|NEDD1_uc001tew.1_Silent_p.L633L|NEDD1_uc001tex.1_Silent_p.L544L	NM_152905	NP_690869	Q8NHV4	NEDD1_HUMAN	neural precursor cell expressed, developmentally	633					cell division|G2/M transition of mitotic cell cycle|mitosis	cytosol					0														0.533333	73.799397	73.842603	24	21	GG		KEEP	---	---	---	---	capture			Silent	SNP	95869878	95869878	10708	12	G	A	A	47	47	NEDD1	A	2	2
AHNAK2	113146	broad.mit.edu	36	14	104489434	104489434	+	Silent	SNP	G	A	A			TCGA-19-2624-01	TCGA-19-2624-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr14:104489434G>A	uc010axc.1	-	c.3399C>T	c.(3397-3399)GTC>GTT	p.V1133V	AHNAK2_uc001ypx.2_Silent_p.V1033V	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1133						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)												0.436997	475.118064	476.413564	163	210	GG		KEEP	---	---	---	---	capture	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)		Silent	SNP	104489434	104489434	418	14	G	A	A	37	37	AHNAK2	A	1	1
TEP1	7011	broad.mit.edu	36	14	19921612	19921612	+	Missense_Mutation	SNP	G	C	C			TCGA-19-2624-01	TCGA-19-2624-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr14:19921612G>C	uc001vxe.1	-	c.3742C>G	c.(3742-3744)CTG>GTG	p.L1248V	TEP1_uc010ahk.1_Missense_Mutation_p.L598V	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1248	NACHT.				telomere maintenance via recombination|telomere maintenance via telomerase	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)												0.307692	8.611999	9.031408	4	9	GG		KEEP	---	---	---	---	capture	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)	Missense_Mutation	SNP	19921612	19921612	16286	14	G	C	C	34	34	TEP1	C	3	3
CYP46A1	10858	broad.mit.edu	36	14	99236161	99236161	+	Missense_Mutation	SNP	G	A	A			TCGA-19-2624-01	TCGA-19-2624-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr14:99236161G>A	uc001ygo.1	+	c.413G>A	c.(412-414)CGG>CAG	p.R138Q	CYP46A1_uc001ygn.1_Missense_Mutation_p.R100Q	NM_006668	NP_006659	Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46	138					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|oxidation-reduction process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity				0		Melanoma(154;0.0866)|all_epithelial(191;0.179)												0.3125	58.977785	60.98013	20	44	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	99236161	99236161	4347	14	G	A	A	39	39	CYP46A1	A	1	1
DUOX2	50506	broad.mit.edu	36	15	43180710	43180710	+	Missense_Mutation	SNP	C	T	T			TCGA-19-2624-01	TCGA-19-2624-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr15:43180710C>T	uc010bea.1	-	c.2906G>A	c.(2905-2907)CGG>CAG	p.R969Q	DUOX2_uc001zun.1_Missense_Mutation_p.R969Q	NM_014080	NP_054799	Q9NRD8	DUOX2_HUMAN	dual oxidase 2 precursor	969	Cytoplasmic (Potential).|Interaction with TXNDC11 (By similarity).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|oxidation-reduction process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			ovary(2)|pancreas(1)	3		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)												0.244444	28.530375	31.189641	11	34	CC		KEEP	---	---	---	---	capture		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)	Missense_Mutation	SNP	43180710	43180710	4986	15	C	T	T	23	23	DUOX2	T	1	1
CBFA2T3	863	broad.mit.edu	36	16	87473289	87473289	+	Missense_Mutation	SNP	C	T	T			TCGA-19-2624-01	TCGA-19-2624-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr16:87473289C>T	uc002fmm.1	-	c.1552G>A	c.(1552-1554)GAG>AAG	p.E518K	CBFA2T3_uc002fmk.1_Missense_Mutation_p.E17K|CBFA2T3_uc002fml.1_Missense_Mutation_p.E432K	NM_005187	NP_005178	O75081	MTG16_HUMAN	myeloid translocation gene on chromosome 16	518	Potential.		E -> K (in a colorectal cancer sample; somatic mutation).		cell proliferation|granulocyte differentiation|regulation of transcription, DNA-dependent	Golgi membrane|nucleolus|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.E518K(1)		large_intestine(3)	3										305				0.15	17.390966	26.768385	12	68	CC		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(80;0.0275)	Missense_Mutation	SNP	87473289	87473289	2817	16	C	T	T	31	31	CBFA2T3	T	1	1
TLCD1	116238	broad.mit.edu	36	17	24076494	24076494	+	Missense_Mutation	SNP	G	T	T			TCGA-19-2624-01	TCGA-19-2624-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr17:24076494G>T	uc002hco.1	-	c.315C>A	c.(313-315)AGC>AGA	p.S105R		NM_138463	NP_612472	Q96CP7	TLCD1_HUMAN	TLC domain containing 1	105	TLC.					integral to membrane					0	Lung NSC(42;0.00431)													0.16	7.087285	9.836773	4	21	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	24076494	24076494	16466	17	G	T	T	38	38	TLCD1	T	3	3
GPR179	440435	broad.mit.edu	36	17	33752829	33752829	+	Missense_Mutation	SNP	C	G	G			TCGA-19-2624-01	TCGA-19-2624-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr17:33752829C>G	uc002hpz.1	-	c.370G>C	c.(370-372)GAG>CAG	p.E124Q		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1	124	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)												0.43299	143.346618	143.723913	42	55	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	33752829	33752829	6949	17	C	G	G	30	30	GPR179	G	3	3
C18orf45	85019	broad.mit.edu	36	18	19143648	19143648	+	Missense_Mutation	SNP	G	A	A			TCGA-19-2624-01	TCGA-19-2624-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr18:19143648G>A	uc002kuf.1	-	c.824C>T	c.(823-825)ACG>ATG	p.T275M	C18orf45_uc002kue.1_Non-coding_Transcript|C18orf45_uc002kug.1_Non-coding_Transcript|C18orf45_uc002kuh.1_Non-coding_Transcript	NM_032933	NP_116322	Q24JQ0	CR045_HUMAN	hypothetical protein LOC85019	275	Helical; (Potential).					integral to membrane					0	all_cancers(21;0.000238)|all_epithelial(16;5.29e-06)|Lung NSC(20;0.00925)|Colorectal(14;0.0202)|all_lung(20;0.0255)|Ovarian(20;0.127)													0.342282	148.379547	151.654421	51	98	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	19143648	19143648	1964	18	G	A	A	40	40	C18orf45	A	1	1
LPHN1	22859	broad.mit.edu	36	19	14133186	14133186	+	Missense_Mutation	SNP	A	C	C			TCGA-19-2624-01	TCGA-19-2624-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr19:14133186A>C	uc002myg.1	-	c.1463T>G	c.(1462-1464)GTC>GGC	p.V488G	LPHN1_uc002myh.1_Missense_Mutation_p.V483G	NM_001008701	NP_001008701	O94910	LPHN1_HUMAN	latrophilin 1 isoform 1 precursor	488	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			ovary(1)|central_nervous_system(1)	2														0.363636	8.38864	8.571738	4	7	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	14133186	14133186	9288	19	A	C	C	10	10	LPHN1	C	4	4
FAM108A1	81926	broad.mit.edu	36	19	1832418	1832418	+	Missense_Mutation	SNP	C	T	T			TCGA-19-2624-01	TCGA-19-2624-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr19:1832418C>T	uc002luf.1	-	c.148G>A	c.(148-150)GCC>ACC	p.A50T	FAM108A1_uc002lug.1_Missense_Mutation_p.A50T|FAM108A1_uc002lud.1_Missense_Mutation_p.A50T|FAM108A1_uc002lue.2_Missense_Mutation_p.A50T	NM_031213	NP_112490	Q96GS6	F18A1_HUMAN	hypothetical protein LOC81926 isoform 1	50						extracellular region	hydrolase activity				0		Ovarian(11;0.000137)												0.189189	14.604309	17.947531	7	30	CC		KEEP	---	---	---	---	capture		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Missense_Mutation	SNP	1832418	1832418	5588	19	C	T	T	26	26	FAM108A1	T	2	2
LRRC25	126364	broad.mit.edu	36	19	18368099	18368099	+	Silent	SNP	G	A	A			TCGA-19-2624-01	TCGA-19-2624-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr19:18368099G>A	uc002niw.1	-	c.675C>T	c.(673-675)AGC>AGT	p.S225S	LRRC25_uc002nix.1_Silent_p.S225S	NM_145256	NP_660299	Q8N386	LRC25_HUMAN	leucine rich repeat containing 25	225	Cytoplasmic (Potential).					integral to membrane					0														0.5	37.072547	37.072547	13	13	GG		KEEP	---	---	---	---	capture			Silent	SNP	18368099	18368099	9354	19	G	A	A	38	38	LRRC25	A	1	1
PLEKHG2	64857	broad.mit.edu	36	19	44605812	44605812	+	Missense_Mutation	SNP	G	A	A			TCGA-19-2624-01	TCGA-19-2624-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr19:44605812G>A	uc002oli.2	+	c.2152G>A	c.(2152-2154)GCA>ACA	p.A718T	PLEKHG2_uc002olj.2_Intron|PLEKHG2_uc010ego.1_Missense_Mutation_p.A689T	NM_022835	NP_073746	Q9H7P9	PKHG2_HUMAN	common-site lymphoma/leukemia guanine nucleotide	760					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			pancreas(1)|breast(1)|skin(1)	3	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)													0.462963	70.765451	70.830293	25	29	GG		KEEP	---	---	---	---	capture	Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)		Missense_Mutation	SNP	44605812	44605812	12495	19	G	A	A	42	42	PLEKHG2	A	2	2
CSDE1	7812	broad.mit.edu	36	1	115074448	115074448	+	Missense_Mutation	SNP	G	C	C			TCGA-19-2624-01	TCGA-19-2624-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:115074448G>C	uc001efi.1	-	c.1448C>G	c.(1447-1449)ACT>AGT	p.T483S	CSDE1_uc001efj.1_Non-coding_Transcript|CSDE1_uc001efl.1_Missense_Mutation_p.T406S|CSDE1_uc001efm.1_Missense_Mutation_p.T452S|CSDE1_uc009wgv.1_Missense_Mutation_p.T437S|CSDE1_uc001efn.1_Missense_Mutation_p.T406S|CSDE1_uc001efk.1_Missense_Mutation_p.T437S	NM_001007553	NP_001007554	O75534	CSDE1_HUMAN	upstream of NRAS isoform 1	437					male gonad development|regulation of transcription, DNA-dependent	cytoplasm	DNA binding|protein binding|RNA binding			ovary(1)	1	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;2.21e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)												0.422078	229.552445	230.368064	65	89	GG		KEEP	---	---	---	---	capture		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Missense_Mutation	SNP	115074448	115074448	4070	1	G	C	C	36	36	CSDE1	C	3	3
F11R	50848	broad.mit.edu	36	1	159236627	159236627	+	Missense_Mutation	SNP	G	A	A			TCGA-19-2624-01	TCGA-19-2624-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:159236627G>A	uc009wtt.1	-	c.524C>T	c.(523-525)ACG>ATG	p.T175M	F11R_uc001fxe.2_Missense_Mutation_p.T175M|F11R_uc009wtu.1_Missense_Mutation_p.T175M|F11R_uc001fxf.2_Missense_Mutation_p.T175M	NM_016946	NP_058642	Q9Y624	JAM1_HUMAN	F11 receptor precursor	175	Ig-like V-type 2.|Extracellular (Potential).				blood coagulation|inflammatory response|interspecies interaction between organisms|leukocyte migration|tight junction assembly	integral to membrane|tight junction				ovary(2)	2	all_cancers(52;6.73e-18)|all_hematologic(112;0.093)													0.5	215.84606	215.84606	70	70	GG		KEEP	---	---	---	---	capture	BRCA - Breast invasive adenocarcinoma(70;0.00207)		Missense_Mutation	SNP	159236627	159236627	5532	1	G	A	A	40	40	F11R	A	1	1
KIF21B	23046	broad.mit.edu	36	1	199226026	199226026	+	Missense_Mutation	SNP	G	C	C			TCGA-19-2624-01	TCGA-19-2624-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:199226026G>C	uc001gvs.1	-	c.2893C>G	c.(2893-2895)CAG>GAG	p.Q965E	KIF21B_uc001gvr.1_Missense_Mutation_p.Q965E|KIF21B_uc009wzl.1_Missense_Mutation_p.Q965E	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	965	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3														0.217391	7.55678	9.258425	5	18	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	199226026	199226026	8600	1	G	C	C	46	46	KIF21B	C	3	3
ZC3H11A	9877	broad.mit.edu	36	1	202085584	202085584	+	Silent	SNP	G	A	A			TCGA-19-2624-01	TCGA-19-2624-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:202085584G>A	uc001hac.1	+	c.1746G>A	c.(1744-1746)CGG>CGA	p.R582R	ZC3H11A_uc001had.1_Silent_p.R582R|ZC3H11A_uc001hae.1_Silent_p.R582R|ZC3H11A_uc001haf.1_Silent_p.R582R|ZC3H11A_uc009xas.1_Silent_p.R582R|ZC3H11A_uc001hag.1_Silent_p.R582R	NM_014827	NP_055642	O75152	ZC11A_HUMAN	zinc finger CCCH-type containing 11A	582							nucleic acid binding|protein binding|zinc ion binding			lung(1)|central_nervous_system(1)	2	all_cancers(21;0.0904)|all_epithelial(62;0.234)													0.507576	216.34135	216.348394	67	65	GG		KEEP	---	---	---	---	capture	BRCA - Breast invasive adenocarcinoma(75;0.109)		Silent	SNP	202085584	202085584	18148	1	G	A	A	43	43	ZC3H11A	A	2	2
TGM3	7053	broad.mit.edu	36	20	2268632	2268632	+	Missense_Mutation	SNP	G	A	A			TCGA-19-2624-01	TCGA-19-2624-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr20:2268632G>A	uc002wfx.2	+	c.1933G>A	c.(1933-1935)GAC>AAC	p.D645N		NM_003245	NP_003236	Q08188	TGM3_HUMAN	transglutaminase 3 precursor	645					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(4)|ovary(3)|breast(1)	8					L-Glutamine(DB00130)									0.4375	22.023223	22.07761	7	9	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	2268632	2268632	16359	20	G	A	A	37	37	TGM3	A	1	1
TGM2	7052	broad.mit.edu	36	20	36209824	36209824	+	Missense_Mutation	SNP	A	G	G			TCGA-19-2624-01	TCGA-19-2624-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr20:36209824A>G	uc002xhr.1	-	c.634T>C	c.(634-636)TCC>CCC	p.S212P	TGM2_uc002xhs.1_Missense_Mutation_p.S188P|TGM2_uc002xht.1_Missense_Mutation_p.S212P|TGM2_uc002xhu.2_Missense_Mutation_p.S212P	NM_004613	NP_004604	P21980	TGM2_HUMAN	transglutaminase 2 isoform a	212					apoptotic cell clearance|peptide cross-linking|positive regulation of cell adhesion		acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(1)|lung(1)|ovary(1)	3		Myeloproliferative disorder(115;0.00878)			L-Glutamine(DB00130)									0.363636	8.088067	8.527792	8	14	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	36209824	36209824	16358	20	A	G	G	11	11	TGM2	G	4	4
SEMG1	6406	broad.mit.edu	36	20	43269884	43269884	+	Missense_Mutation	SNP	G	A	A			TCGA-19-2624-01	TCGA-19-2624-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr20:43269884G>A	uc002xni.1	+	c.532G>A	c.(532-534)GTC>ATC	p.V178I	SEMG1_uc002xnh.1_Missense_Mutation_p.V178I|SEMG1_uc002xnj.1_Missense_Mutation_p.V178I|SEMG2_uc010ggz.1_Intron	NM_003007	NP_002998	P04279	SEMG1_HUMAN	semenogelin I isoform a preproprotein	178	42 AA repeat 1.				insemination|sexual reproduction	extracellular space|stored secretory granule	structural molecule activity				0		Myeloproliferative disorder(115;0.0122)												0.495495	166.408436	166.410524	55	56	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	43269884	43269884	14530	20	G	A	A	40	40	SEMG1	A	1	1
KRTAP6-1	337966	broad.mit.edu	36	21	30907926	30907926	+	Missense_Mutation	SNP	A	T	T			TCGA-19-2624-01	TCGA-19-2624-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr21:30907926A>T	uc002yop.1	-	c.169T>A	c.(169-171)TGT>AGT	p.C57S	KRTAP20-1_uc002yoq.1_5'Flank	NM_181602	NP_853633	Q3LI64	KRA61_HUMAN	keratin associated protein 6-1	57						cytosol|intermediate filament					0														0.205128	77.829624	90.399489	32	124	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	30907926	30907926	8891	21	A	T	T	7	7	KRTAP6-1	T	4	4
CECR2	27443	broad.mit.edu	36	22	16362144	16362144	+	Silent	SNP	C	G	G			TCGA-19-2624-01	TCGA-19-2624-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr22:16362144C>G	uc010gqw.1	+	c.555C>G	c.(553-555)TCC>TCG	p.S185S	CECR2_uc010gqv.1_Silent_p.S64S|CECR2_uc002zml.2_Silent_p.S64S|CECR2_uc002zmm.1_Silent_p.S64S	NM_031413	NP_113601	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	227					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			ovary(1)|skin(1)	2		all_epithelial(15;0.139)												0.230769	6.917806	7.781811	3	10	CC		KEEP	---	---	---	---	capture		Lung(27;0.146)	Silent	SNP	16362144	16362144	3339	22	C	G	G	23	23	CECR2	G	3	3
MYH9	4627	broad.mit.edu	36	22	35019338	35019338	+	Missense_Mutation	SNP	C	T	T			TCGA-19-2624-01	TCGA-19-2624-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr22:35019338C>T	uc003apg.1	-	c.4078G>A	c.(4078-4080)GCC>ACC	p.A1360T		NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	1360	Potential.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	10										1624				0.470588	132.79975	132.874524	48	54	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	35019338	35019338	10437	22	C	T	T	27	27	MYH9	T	1	1
KCTD18	130535	broad.mit.edu	36	2	201079870	201079870	+	Missense_Mutation	SNP	C	A	A			TCGA-19-2624-01	TCGA-19-2624-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr2:201079870C>A	uc002uvs.1	-	c.115G>T	c.(115-117)GCA>TCA	p.A39S	KCTD18_uc002uvt.1_Missense_Mutation_p.A39S|KCTD18_uc002uvu.1_Missense_Mutation_p.A39S	NM_152387	NP_689600	Q6PI47	KCD18_HUMAN	potassium channel tetramerisation domain	39	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1														0.355263	78.302578	79.705896	27	49	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	201079870	201079870	8411	2	C	A	A	26	26	KCTD18	A	3	3
PARD3B	117583	broad.mit.edu	36	2	205694677	205694677	+	Silent	SNP	T	C	C			TCGA-19-2624-01	TCGA-19-2624-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr2:205694677T>C	uc002var.1	+	c.924T>C	c.(922-924)GGT>GGC	p.G308G	PARD3B_uc010fub.1_Silent_p.G308G|PARD3B_uc002vao.1_Silent_p.G308G|PARD3B_uc002vap.1_Silent_p.G308G|PARD3B_uc002vaq.1_Silent_p.G308G	NM_152526	NP_689739	Q8TEW8	PAR3L_HUMAN	par-3 partitioning defective 3 homolog B isoform	308					cell cycle|cell division	endomembrane system|tight junction				ovary(1)|breast(1)	2		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)												0.428571	208.284185	208.905544	60	80	TT		KEEP	---	---	---	---	capture		Epithelial(149;0.0739)	Silent	SNP	205694677	205694677	11861	2	T	C	C	57	57	PARD3B	C	4	4
ALPP	250	broad.mit.edu	36	2	232952597	232952597	+	Missense_Mutation	SNP	G	A	A			TCGA-19-2624-01	TCGA-19-2624-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr2:232952597G>A	uc002vsq.1	+	c.440G>A	c.(439-441)CGC>CAC	p.R147H	ALPP_uc002vsr.1_5'Flank	NM_001632	NP_001623	P05187	PPB1_HUMAN	placental alkaline phosphatase preproprotein	147						anchored to membrane|cell surface|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			ovary(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)												0.285714	26.048421	27.482959	10	25	GG		KEEP	---	---	---	---	capture		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Missense_Mutation	SNP	232952597	232952597	551	2	G	A	A	38	38	ALPP	A	1	1
NMUR2	56923	broad.mit.edu	36	5	151764410	151764410	+	Missense_Mutation	SNP	C	T	T			TCGA-19-2624-01	TCGA-19-2624-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr5:151764410C>T	uc003luv.2	-	c.458G>A	c.(457-459)CGC>CAC	p.R153H		NM_020167	NP_064552	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	153	Cytoplasmic (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			ovary(2)	2		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)												0.443299	125.025181	125.293867	43	54	CC		KEEP	---	---	---	---	capture	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)		Missense_Mutation	SNP	151764410	151764410	10910	5	C	T	T	27	27	NMUR2	T	1	1
GABRG2	2566	broad.mit.edu	36	5	161511321	161511321	+	Missense_Mutation	SNP	G	A	A			TCGA-19-2624-01	TCGA-19-2624-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr5:161511321G>A	uc010jjc.1	+	c.1256G>A	c.(1255-1257)CGG>CAG	p.R419Q	GABRG2_uc003lyy.2_Missense_Mutation_p.R379Q|GABRG2_uc003lyz.2_Intron	NM_198903	NP_944493	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	376	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)	4	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)												0.389706	166.852138	168.298822	53	83	GG		KEEP	---	---	---	---	capture	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)	Missense_Mutation	SNP	161511321	161511321	6423	5	G	A	A	39	39	GABRG2	A	1	1
PLCXD3	345557	broad.mit.edu	36	5	41349603	41349603	+	Missense_Mutation	SNP	A	T	T			TCGA-19-2624-01	TCGA-19-2624-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr5:41349603A>T	uc003jmm.1	-	c.839T>A	c.(838-840)GTC>GAC	p.V280D		NM_001005473	NP_001005473	Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X	280					intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			urinary_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	4														0.492537	102.97622	102.979364	33	34	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	41349603	41349603	12469	5	A	T	T	10	10	PLCXD3	T	4	4
AKD1	221264	broad.mit.edu	36	6	110100025	110100025	+	Missense_Mutation	SNP	C	T	T			TCGA-19-2624-01	TCGA-19-2624-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr6:110100025C>T	uc003ptr.2	-	c.220G>A	c.(220-222)GAA>AAA	p.E74K	AKD1_uc003pts.1_Non-coding_Transcript	NM_145025	NP_659462	Q5TCS8	AKD1_HUMAN	hypothetical protein LOC221264 isoform 2	74					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|nucleoside-triphosphatase activity			ovary(1)	1														0.4	65.338015	65.819274	22	33	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	110100025	110100025	463	6	C	T	T	31	31	AKD1	T	1	1
VNN1	8876	broad.mit.edu	36	6	133047233	133047233	+	Silent	SNP	G	A	A			TCGA-19-2624-01	TCGA-19-2624-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr6:133047233G>A	uc003qdo.1	-	c.1293C>T	c.(1291-1293)TTC>TTT	p.F431F	VNN1_uc003qdn.1_Non-coding_Transcript	NM_004666	NP_004657	O95497	VNN1_HUMAN	vanin 1 precursor	431					acute inflammatory response|anti-apoptosis|cell-cell adhesion|cellular component movement|chronic inflammatory response|innate immune response|pantothenate metabolic process|positive regulation of T cell differentiation in thymus|response to oxidative stress	anchored to membrane|integral to membrane|plasma membrane	GPI anchor binding|pantetheine hydrolase activity			ovary(3)	3	Breast(56;0.135)													0.484848	152.599579	152.619122	48	51	GG		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(155;0.0027)|GBM - Glioblastoma multiforme(226;0.0189)	Silent	SNP	133047233	133047233	17749	6	G	A	A	37	37	VNN1	A	1	1
C6orf195	154386	broad.mit.edu	36	6	2568742	2568742	+	Missense_Mutation	SNP	G	C	C			TCGA-19-2624-01	TCGA-19-2624-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr6:2568742G>C	uc003mtw.2	-	c.314C>G	c.(313-315)GCC>GGC	p.A105G	C6orf195_uc010jng.1_Missense_Mutation_p.A105G	NM_152554	NP_689767	Q96MT4	CF195_HUMAN	hypothetical protein LOC154386	105											0	Ovarian(93;0.0412)	all_hematologic(90;0.0895)												0.576271	119.156271	119.459648	34	25	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	2568742	2568742	2455	6	G	C	C	42	42	C6orf195	C	3	3
TRIM40	135644	broad.mit.edu	36	6	30222839	30222839	+	Silent	SNP	C	G	G			TCGA-19-2624-01	TCGA-19-2624-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr6:30222839C>G	uc003npk.2	+	c.540C>G	c.(538-540)GGC>GGG	p.G180G	TRIM40_uc003npm.2_Silent_p.G151G	NM_138700	NP_619645	Q6P9F5	TRI40_HUMAN	tripartite motif-containing 40	180						intracellular	zinc ion binding			ovary(1)	1														0.291667	7.588932	8.618082	7	17	CC		KEEP	---	---	---	---	capture			Silent	SNP	30222839	30222839	17059	6	C	G	G	26	26	TRIM40	G	3	3
STEAP1	26872	broad.mit.edu	36	7	89631974	89631974	+	Missense_Mutation	SNP	C	A	A			TCGA-19-2624-01	TCGA-19-2624-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr7:89631974C>A	uc003ujx.1	+	c.1010C>A	c.(1009-1011)TCC>TAC	p.S337Y	STEAP2_uc003ujy.2_5'Flank	NM_012449	NP_036581	Q9UHE8	STEA1_HUMAN	six transmembrane epithelial antigen of the	337					electron transport chain|ion transport|iron ion homeostasis	cell-cell junction|endosome membrane|integral to plasma membrane	channel activity|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	all_hematologic(106;0.112)													0.2	26.538329	31.979944	13	52	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	89631974	89631974	15797	7	C	A	A	30	30	STEAP1	A	3	3
DAB2IP	153090	broad.mit.edu	36	9	123578325	123578325	+	Nonsense_Mutation	SNP	C	T	T			TCGA-19-2624-01	TCGA-19-2624-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr9:123578325C>T	uc004bln.1	+	c.3064C>T	c.(3064-3066)CGA>TGA	p.R1022*	DAB2IP_uc004blo.1_Nonsense_Mutation_p.R926*|DAB2IP_uc004blp.1_Nonsense_Mutation_p.R455*	NM_032552	NP_115941	Q5VWQ8	DAB2P_HUMAN	disabled homolog 2 interacting protein isoform	1050	Potential.				activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of gene-specific transcription from RNA polymerase II promoter|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of Ras protein signal transduction|positive regulation of apoptosis|positive regulation of gene-specific transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			ovary(1)|central_nervous_system(1)	2														0.5	6.95024	6.950239	2	2	CC		KEEP	---	---	---	---	capture			Nonsense_Mutation	SNP	123578325	123578325	4385	9	C	T	T	27	27	DAB2IP	T	5	1
WDR34	89891	broad.mit.edu	36	9	130437347	130437347	+	Missense_Mutation	SNP	G	C	C			TCGA-19-2624-01	TCGA-19-2624-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr9:130437347G>C	uc004bvq.1	-	c.826C>G	c.(826-828)CCC>GCC	p.P276A	WDR34_uc004bvr.1_Intron|WDR34_uc004bvs.1_Missense_Mutation_p.P267A	NM_052844	NP_443076	Q96EX3	WDR34_HUMAN	WD repeat domain 34	276	WD 2.					cytoplasm				central_nervous_system(2)|skin(1)	3												OREG0019522	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0.380952	8.690438	9.016535	8	13	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	130437347	130437347	17861	9	G	C	C	42	42	WDR34	C	3	3
MAGEB18	286514	broad.mit.edu	36	X	26067231	26067231	+	Missense_Mutation	SNP	A	G	G			TCGA-19-2624-01	TCGA-19-2624-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chrX:26067231A>G	uc004dbq.1	+	c.208A>G	c.(208-210)ACC>GCC	p.T70A	MAGEB18_uc010ngb.1_Missense_Mutation_p.T70A	NM_173699	NP_775970	Q96M61	MAGBI_HUMAN	melanoma antigen family B, 18	70							protein binding			central_nervous_system(1)	1														0.84375	89.033991	92.639129	27	5	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	26067231	26067231	9556	23	A	G	G	6	6	MAGEB18	G	4	4
TBC1D10C	374403	broad.mit.edu	36	11	66933735	66933735	+	Frame_Shift_Del	DEL	C	-	-			TCGA-19-2624-01	TCGA-19-2624-01										Phase_I	Unspecified				Illumina GAIIx	g.chr11:66933735_66933735delC	uc001ola.1	+	c.1275_1275delC	c.(1273-1275)GGCfs	p.G425fs	PPP1CA_uc001okx.1_Intron|TBC1D10C_uc001okz.1_3'UTR|TBC1D10C_uc001olb.1_Non-coding_Transcript	NM_198517	NP_940919	Q8IV04	TB10C_HUMAN	TBC1 domain family, member 10C	425	Interaction with calcineurin.					intracellular	Rab GTPase activator activity				0			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)											0.47			26	29				---	---	---	---	capture_indel			Frame_Shift_Del	DEL	66933735	66933735	16122	11	C	-	-	26	26	TBC1D10C	-	5	5
