Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	i_TCGAscape_Amplification_Peaks	i_TCGAscape_Deletion_Peaks	DrugBank	i_ACHILLES_Top_Genes	i_CCLE_ONCOMAP_overlapping_mutations	i_CCLE_ONCOMAP_total_mutations_in_gene	i_CCLE_SEQ_overlapping_mutations	i_CCLE_SEQ_total_mutations_in_gene	MUTSIG_Significant_Genes	OREGANNO_ID	OREGANNO_Values	i_tumor_f	i_init_t_lod	i_t_lod_fstar	i_t_alt_count	i_t_ref_count	i_normal_best_gt	i_failure_reasons	i_judgement	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	dataset	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	type	classification	start	end	gene	chr	ref_allele	tum_allele1	tum_allele2	context_orig	context65	gene_name	newbase	categ	categ_ignoring_null_categ
PWWP2B	170394	broad.mit.edu	36	10	134069635	134069636	+	Missense_Mutation	DNP	CT	GG	GG			TCGA-26-1799-01	TCGA-26-1799-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:134069635_134069636CT>GG	uc001lll.2	+	c.1641_1642CT>GG	c.(1639-1644)TTCTCT>TTGGCT	p.547_548FS>LA	PWWP2B_uc009ybe.1_Intron	NM_138499	NP_612508	Q6NUJ5	PWP2B_HUMAN	PWWP domain containing 2 isoform 1	547_548	PWWP.										0		all_cancers(35;6.69e-12)|all_epithelial(44;1.55e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)|all_hematologic(284;0.224)		OV - Ovarian serous cystadenocarcinoma(35;7.49e-05)|Epithelial(32;0.00016)|all cancers(32;0.000186)										0.833333	12.606486	13.203979	5	1	CC		KEEP	---	---	---	---	capture			Missense_Mutation	DNP	134069635	134069636	13304	10	CT	GG	GG	32	32	PWWP2B	GG	3	3
AHNAK	79026	broad.mit.edu	36	11	62046008	62046008	+	Missense_Mutation	SNP	T	C	C			TCGA-26-1799-01	TCGA-26-1799-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr11:62046008T>C	uc001ntl.1	-	c.12457A>G	c.(12457-12459)AAA>GAA	p.K4153E	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	4153					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)	14		Melanoma(852;0.155)												0.283019	78.101472	82.587456	30	76	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	62046008	62046008	417	11	T	C	C	63	63	AHNAK	C	4	4
ARHGDIB	397	broad.mit.edu	36	12	14989008	14989008	+	Silent	SNP	G	A	A			TCGA-26-1799-01	TCGA-26-1799-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr12:14989008G>A	uc001rcq.1	-	c.375C>T	c.(373-375)TAC>TAT	p.Y125Y	ARHGDIB_uc001rcp.1_Non-coding_Transcript	NM_001175	NP_001166	P52566	GDIR2_HUMAN	Rho GDP dissociation inhibitor (GDI) beta	125					actin cytoskeleton organization|cellular component movement|immune response|multicellular organismal development|negative regulation of cell adhesion|regulation of small GTPase mediated signal transduction|Rho protein signal transduction	cytoplasmic membrane-bounded vesicle|cytoskeleton|cytosol	GTPase activator activity|Rho GDP-dissociation inhibitor activity				0										108				0.583942	268.233077	269.08142	80	57	GG		KEEP	---	---	---	---	capture			Silent	SNP	14989008	14989008	905	12	G	A	A	40	40	ARHGDIB	A	1	1
STAC3	246329	broad.mit.edu	36	12	55928834	55928834	+	Silent	SNP	A	T	T			TCGA-26-1799-01	TCGA-26-1799-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr12:55928834A>T	uc001snp.1	-	c.354T>A	c.(352-354)CTT>CTA	p.L118L	STAC3_uc001snq.1_Silent_p.L79L|STAC3_uc009zpl.1_Intron	NM_145064	NP_659501	Q96MF2	STAC3_HUMAN	SH3 and cysteine rich domain 3	118	Phorbol-ester/DAG-type.				intracellular signal transduction		identical protein binding|metal ion binding			ovary(2)	2														0.155172	7.62804	14.240359	9	49	AA		KEEP	---	---	---	---	capture			Silent	SNP	55928834	55928834	15759	12	A	T	T	9	9	STAC3	T	4	4
PTPN6	5777	broad.mit.edu	36	12	6939804	6939804	+	Missense_Mutation	SNP	A	C	C			TCGA-26-1799-01	TCGA-26-1799-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr12:6939804A>C	uc009zfl.1	+	c.1618A>C	c.(1618-1620)ACC>CCC	p.T540P	PTPN6_uc001qsa.1_Missense_Mutation_p.T542P|PTPN6_uc001qsb.2_Missense_Mutation_p.T540P	NM_080549	NP_536859	P29350	PTN6_HUMAN	protein tyrosine phosphatase, non-receptor type	540					apoptosis|cell junction assembly|G-protein coupled receptor protein signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|negative regulation of peptidyl-tyrosine phosphorylation|platelet activation|positive regulation of cell proliferation|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of G1/S transition of mitotic cell cycle|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol|membrane|nucleus	protein binding|protein tyrosine phosphatase activity			breast(1)	1														0.428571	7.919663	7.951508	3	4	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	6939804	6939804	13249	12	A	C	C	6	6	PTPN6	C	4	4
ITM2B	9445	broad.mit.edu	36	13	47730262	47730262	+	Splice_Site_SNP	SNP	G	A	A			TCGA-26-1799-01	TCGA-26-1799-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr13:47730262G>A	uc001vbz.2	+	c.e7_splice_site				NM_021999	NP_068839			integral membrane protein 2B						nervous system development	Golgi membrane|integral to membrane|nucleus|plasma membrane	beta-amyloid binding				0		all_cancers(8;2.2e-31)|all_epithelial(8;6.77e-15)|all_lung(13;9.67e-07)|all_hematologic(8;9.72e-06)|Lung NSC(96;8.3e-05)|Breast(56;0.000141)|Acute lymphoblastic leukemia(8;0.00045)|Prostate(109;0.000669)|Myeloproliferative disorder(33;0.039)|Hepatocellular(98;0.0556)|Lung SC(185;0.102)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(144;1.97e-06)										0.505051	158.947087	158.94929	50	49	GG		KEEP	---	---	---	---	capture			Splice_Site_SNP	SNP	47730262	47730262	8217	13	G	A	A	33	33	ITM2B	A	5	2
MAP3K9	4293	broad.mit.edu	36	14	70269297	70269297	+	Missense_Mutation	SNP	A	G	G			TCGA-26-1799-01	TCGA-26-1799-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr14:70269297A>G	uc001xml.1	-	c.2584T>C	c.(2584-2586)TCC>CCC	p.S862P	MAP3K9_uc001xmk.1_Missense_Mutation_p.S581P|MAP3K9_uc001xmm.1_Missense_Mutation_p.S848P	NM_033141	NP_149132	P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase	848					activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			stomach(1)|lung(1)|central_nervous_system(1)|skin(1)	4				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		GBM(114;411 1587 13539 28235 50070)				190				0.192308	6.765355	9.063853	5	21	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	70269297	70269297	9640	14	A	G	G	11	11	MAP3K9	G	4	4
FLVCR2	55640	broad.mit.edu	36	14	75115449	75115449	+	Silent	SNP	C	T	T			TCGA-26-1799-01	TCGA-26-1799-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr14:75115449C>T	uc001xrs.2	+	c.381C>T	c.(379-381)TCC>TCT	p.S127S		NM_017791	NP_060261	Q9UPI3	FLVC2_HUMAN	feline leukemia virus subgroup C cellular	127	Helical; (Potential).				transmembrane transport	integral to membrane|plasma membrane	heme binding|heme transporter activity				0				BRCA - Breast invasive adenocarcinoma(234;0.029)										0.188679	34.372036	48.822922	30	129	CC		KEEP	---	---	---	---	capture			Silent	SNP	75115449	75115449	6188	14	C	T	T	21	21	FLVCR2	T	2	2
ATP10A	57194	broad.mit.edu	36	15	23577346	23577346	+	Silent	SNP	G	C	C			TCGA-26-1799-01	TCGA-26-1799-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr15:23577346G>C	uc010ayu.1	-	c.567C>G	c.(565-567)CCC>CCG	p.P189P		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	189	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)					p.P189P(HEC59-Tumor)	877				0.216216	12.478138	15.232972	8	29	GG		KEEP	---	---	---	---	capture			Silent	SNP	23577346	23577346	1135	15	G	C	C	39	39	ATP10A	C	3	3
ANPEP	290	broad.mit.edu	36	15	88150699	88150699	+	Silent	SNP	G	A	A			TCGA-26-1799-01	TCGA-26-1799-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr15:88150699G>A	uc002bop.2	-	c.120C>T	c.(118-120)AAC>AAT	p.N40N		NM_001150	NP_001141	P15144	AMPN_HUMAN	membrane alanine aminopeptidase precursor	40	Extracellular.|Cytosolic Ser/Thr-rich junction.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			ovary(3)	3	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	NSCLC(30;827 977 2459 19669 26125)								0.428571	16.647649	16.709868	6	8	GG		KEEP	---	---	---	---	capture			Silent	SNP	88150699	88150699	718	15	G	A	A	40	40	ANPEP	A	1	1
DNAH3	55567	broad.mit.edu	36	16	20904303	20904303	+	Missense_Mutation	SNP	C	T	T			TCGA-26-1799-01	TCGA-26-1799-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr16:20904303C>T	uc002did.1	-	c.7262G>A	c.(7261-7263)CGT>CAT	p.R2421H	DNAH3_uc002dic.1_5'Flank	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2421	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(10)|large_intestine(2)|central_nervous_system(2)	14				GBM - Glioblastoma multiforme(48;0.207)										0.419355	75.840831	76.192059	26	36	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	20904303	20904303	4786	16	C	T	T	19	19	DNAH3	T	1	1
CLDN9	9080	broad.mit.edu	36	16	3004012	3004012	+	Silent	SNP	C	T	T			TCGA-26-1799-01	TCGA-26-1799-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr16:3004012C>T	uc002cst.1	+	c.648C>T	c.(646-648)TAC>TAT	p.Y216Y		NM_020982	NP_066192	O95484	CLD9_HUMAN	claudin 9	216	Cytoplasmic (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity				0														0.5	11.486753	11.486753	4	4	CC		KEEP	---	---	---	---	capture			Silent	SNP	3004012	3004012	3629	16	C	T	T	19	19	CLDN9	T	1	1
FOXC2	2303	broad.mit.edu	36	16	85158940	85158940	+	Silent	SNP	G	A	A			TCGA-26-1799-01	TCGA-26-1799-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr16:85158940G>A	uc002fjq.1	+	c.498G>A	c.(496-498)CGG>CGA	p.R166R		NM_005251	NP_005242	Q99958	FOXC2_HUMAN	forkhead box C2	166	Poly-Arg.				anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|embryonic viscerocranium morphogenesis|insulin receptor signaling pathway|lymphangiogenesis|metanephros development|negative regulation of gene-specific transcription from RNA polymerase II promoter|neural crest cell fate commitment|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of cell adhesion mediated by integrin|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of gene-specific transcription from RNA polymerase II promoter|positive regulation of vascular wound healing|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0														0.3	8.283567	8.606346	3	7	GG		KEEP	---	---	---	---	capture			Silent	SNP	85158940	85158940	6237	16	G	A	A	42	42	FOXC2	A	2	2
ST8SIA3	51046	broad.mit.edu	36	18	53175556	53175556	+	Silent	SNP	C	T	T			TCGA-26-1799-01	TCGA-26-1799-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr18:53175556C>T	uc002lgn.1	+	c.717C>T	c.(715-717)GAC>GAT	p.D239D		NM_015879	NP_056963	O43173	SIA8C_HUMAN	ST8 alpha-N-acetyl-neuraminide	239	Lumenal (Potential).				glycosphingolipid biosynthetic process|N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(1)	1				READ - Rectum adenocarcinoma(59;0.19)|Colorectal(16;0.205)										0.163043	28.771137	38.69716	15	77	CC		KEEP	---	---	---	---	capture			Silent	SNP	53175556	53175556	15751	18	C	T	T	19	19	ST8SIA3	T	1	1
FFAR2	2867	broad.mit.edu	36	19	40632676	40632676	+	Missense_Mutation	SNP	C	T	T			TCGA-26-1799-01	TCGA-26-1799-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr19:40632676C>T	uc002nzg.2	+	c.220C>T	c.(220-222)CGC>TGC	p.R74C	FFAR2_uc010eea.1_Missense_Mutation_p.R74C	NM_005306	NP_005297	O15552	FFAR2_HUMAN	free fatty acid receptor 2	74	Extracellular (Potential).					integral to plasma membrane	G-protein coupled receptor activity|lipid binding			central_nervous_system(1)	1	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			GBM(40;139 809 9833 23358 48736)				34				0.333333	48.760616	50.013941	17	34	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	40632676	40632676	6065	19	C	T	T	23	23	FFAR2	T	1	1
NCCRP1	342897	broad.mit.edu	36	19	44383204	44383204	+	Missense_Mutation	SNP	G	A	A			TCGA-26-1799-01	TCGA-26-1799-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr19:44383204G>A	uc002okq.1	+	c.796G>A	c.(796-798)GAC>AAC	p.D266N		NM_001001414	NP_001001414	Q6ZVX7	NCRP1_HUMAN	non-specific cytotoxic cell receptor protein 1	266	FBA.				protein catabolic process					ovary(1)	1						Melanoma(107;1207 1556 14956 29427 52130)								0.307692	9.695538	10.123953	4	9	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	44383204	44383204	10612	19	G	A	A	37	37	NCCRP1	A	1	1
TNFRSF1B	7133	broad.mit.edu	36	1	12189424	12189424	+	Silent	SNP	C	T	T			TCGA-26-1799-01	TCGA-26-1799-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:12189424C>T	uc001att.1	+	c.1146C>T	c.(1144-1146)ACC>ACT	p.T382T	TNFRSF1B_uc001atu.1_Silent_p.T187T|TNFRSF1B_uc009vnk.1_Non-coding_Transcript	NM_001066	NP_001057	P20333	TNR1B_HUMAN	tumor necrosis factor receptor 2 precursor	382	Cytoplasmic (Potential).				apoptosis	extracellular region|integral to membrane|membrane raft|plasma membrane	tumor necrosis factor receptor activity			liver(1)|central_nervous_system(1)	2	Ovarian(185;0.249)	Lung NSC(185;8.72e-05)|all_lung(284;9.92e-05)|Renal(390;0.000147)|Colorectal(325;0.000584)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;5.52e-07)|COAD - Colon adenocarcinoma(227;0.000345)|BRCA - Breast invasive adenocarcinoma(304;0.000353)|Kidney(185;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00302)|STAD - Stomach adenocarcinoma(313;0.00815)|READ - Rectum adenocarcinoma(331;0.0284)	Etanercept(DB00005)|Infliximab(DB00065)					222				0.282258	101.182152	106.458011	35	89	CC		KEEP	---	---	---	---	capture			Silent	SNP	12189424	12189424	16835	1	C	T	T	24	24	TNFRSF1B	T	2	2
PMVK	10654	broad.mit.edu	36	1	153168219	153168219	+	Missense_Mutation	SNP	G	A	A			TCGA-26-1799-01	TCGA-26-1799-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:153168219G>A	uc001ffq.1	-	c.217C>T	c.(217-219)CGG>TGG	p.R73W		NM_006556	NP_006547	Q15126	PMVK_HUMAN	phosphomevalonate kinase	73				R->M: Approximately 3000-fold decrease in Vmax for MgATP and R-MVP. No change in Km for MgATP and approximately 3-fold increase in Km for R-MVP.	cholesterol biosynthetic process|protein phosphorylation	cytosol|peroxisome	ATP binding|phosphomevalonate kinase activity|protein binding				0	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.142)		BRCA - Breast invasive adenocarcinoma(34;0.00034)											0.23	110.20709	123.533711	46	154	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	153168219	153168219	12570	1	G	A	A	37	37	PMVK	A	1	1
FMO1	2326	broad.mit.edu	36	1	169516579	169516579	+	Missense_Mutation	SNP	G	A	A			TCGA-26-1799-01	TCGA-26-1799-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:169516579G>A	uc009wvz.1	+	c.658G>A	c.(658-660)GTG>ATG	p.V220M	FMO1_uc001ghl.1_Missense_Mutation_p.V220M|FMO1_uc001ghm.1_Missense_Mutation_p.V220M|FMO1_uc001ghn.1_Missense_Mutation_p.V220M	NM_002021	NP_002012	Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	220					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding				0	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)													0.289855	47.932736	50.693817	20	49	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	169516579	169516579	6196	1	G	A	A	44	44	FMO1	A	2	2
RFWD2	64326	broad.mit.edu	36	1	174384775	174384775	+	Missense_Mutation	SNP	T	C	C			TCGA-26-1799-01	TCGA-26-1799-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr1:174384775T>C	uc001gku.1	-	c.821A>G	c.(820-822)AAT>AGT	p.N274S	RFWD2_uc009wwv.1_Missense_Mutation_p.N10S|RFWD2_uc001gkt.1_Missense_Mutation_p.N133S|RFWD2_uc001gkv.1_Missense_Mutation_p.N270S|RFWD2_uc001gkw.1_Missense_Mutation_p.N34S	NM_022457	NP_071902	Q8NHY2	RFWD2_HUMAN	ring finger and WD repeat domain 2 isoform a	274	Potential.				DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	centrosome|cytosol|focal adhesion|nuclear speck	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0						Ovarian(134;1413 1765 5706 35534 51541)								0.366667	35.120771	35.588205	11	19	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	174384775	174384775	13732	1	T	C	C	52	52	RFWD2	C	4	4
CDC73	79577	broad.mit.edu	36	1	191448185	191448185	+	Missense_Mutation	SNP	C	T	T			TCGA-26-1799-01	TCGA-26-1799-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:191448185C>T	uc001gtb.1	+	c.1109C>T	c.(1108-1110)TCT>TTT	p.S370F		NM_024529	NP_078805	Q6P1J9	CDC73_HUMAN	parafibromin	370					cell cycle|histone H2B ubiquitination|histone monoubiquitination|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			parathyroid(44)|ovary(1)|pancreas(1)	46										312				0.085586	9.349794	48.001765	19	203	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	191448185	191448185	3214	1	C	T	T	32	32	CDC73	T	2	2
LGR6	59352	broad.mit.edu	36	1	200512121	200512121	+	Missense_Mutation	SNP	C	T	T			TCGA-26-1799-01	TCGA-26-1799-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:200512121C>T	uc001gxu.1	+	c.493C>T	c.(493-495)CGC>TGC	p.R165C	LGR6_uc001gxv.1_Missense_Mutation_p.R113C|LGR6_uc009xab.1_Non-coding_Transcript|LGR6_uc001gxw.1_Intron|LGR6_uc009xac.1_Non-coding_Transcript	NM_001017403	NP_001017403	Q9HBX8	LGR6_HUMAN	leucine-rich repeat-containing G protein-coupled	165	LRR 4.|Extracellular (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			large_intestine(4)|ovary(3)|pancreas(1)	8														0.12	10.428859	21.051204	9	66	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	200512121	200512121	9084	1	C	T	T	23	23	LGR6	T	1	1
MIA3	375056	broad.mit.edu	36	1	220869390	220869390	+	Silent	SNP	C	T	T			TCGA-26-1799-01	TCGA-26-1799-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:220869390C>T	uc001hnl.1	+	c.2205C>T	c.(2203-2205)AAC>AAT	p.N735N	MIA3_uc009xea.1_Silent_p.N571N	NM_198551	NP_940953	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	735	Extracellular (Potential).				exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(4)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(131;0.0199)										0.521127	118.576163	118.603879	37	34	CC		KEEP	---	---	---	---	capture			Silent	SNP	220869390	220869390	9955	1	C	T	T	19	19	MIA3	T	1	1
MANEAL	149175	broad.mit.edu	36	1	38038190	38038190	+	Missense_Mutation	SNP	C	T	T			TCGA-26-1799-01	TCGA-26-1799-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:38038190C>T	uc001cby.2	+	c.1102C>T	c.(1102-1104)CGG>TGG	p.R368W	MANEAL_uc001cbx.2_3'UTR|MANEAL_uc001cbz.2_Missense_Mutation_p.R146W	NM_001113482	NP_001106954	Q5VSG8	MANEL_HUMAN	mannosidase, endo-alpha-like isoform 3	368	Lumenal (Potential).					Golgi membrane|integral to membrane	hydrolase activity				0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)												0.434426	163.073319	163.52619	53	69	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	38038190	38038190	9605	1	C	T	T	31	31	MANEAL	T	1	1
HECTD3	79654	broad.mit.edu	36	1	45245805	45245805	+	Missense_Mutation	SNP	G	C	C			TCGA-26-1799-01	TCGA-26-1799-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:45245805G>C	uc009vxk.1	-	c.1370C>G	c.(1369-1371)GCT>GGT	p.A457G	HECTD3_uc001cmx.2_5'Flank|HECTD3_uc001cmy.2_Missense_Mutation_p.A67G	NM_024602	NP_078878	Q5T447	HECD3_HUMAN	HECT domain containing 3	457					proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of mitotic metaphase/anaphase transition	anaphase-promoting complex|perinuclear region of cytoplasm	ubiquitin-protein ligase activity				0	Acute lymphoblastic leukemia(166;0.155)													0.15	6.738683	11.430186	6	34	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	45245805	45245805	7324	1	G	C	C	34	34	HECTD3	C	3	3
MUTYH	4595	broad.mit.edu	36	1	45569682	45569682	+	Silent	SNP	C	T	T			TCGA-26-1799-01	TCGA-26-1799-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:45569682C>T	uc009vxp.1	-	c.1320G>A	c.(1318-1320)GGG>GGA	p.G440G	MUTYH_uc009vxn.1_Silent_p.G262G|MUTYH_uc001cnf.1_Silent_p.G412G|MUTYH_uc009vxo.1_Silent_p.G412G|MUTYH_uc001cng.1_Silent_p.G423G|MUTYH_uc001cnj.1_Silent_p.G320G|MUTYH_uc001cni.1_Silent_p.G412G|MUTYH_uc001cnh.1_Silent_p.G413G|MUTYH_uc001cnm.1_Silent_p.G437G|MUTYH_uc001cno.1_Silent_p.G320G|MUTYH_uc001cnk.1_Silent_p.G297G|MUTYH_uc001cnl.1_Silent_p.G426G|MUTYH_uc001cnn.1_Silent_p.G427G	NM_001128425	NP_001121897	Q9UIF7	MUTYH_HUMAN	mutY homolog isoform 5	437	Nudix hydrolase.				depurination|mismatch repair	nucleoplasm	4 iron, 4 sulfur cluster binding|DNA N-glycosylase activity|endonuclease activity|metal ion binding|MutSalpha complex binding				0	Acute lymphoblastic leukemia(166;0.155)									162				0.27027	24.239148	25.997599	10	27	CC		KEEP	---	---	---	---	capture			Silent	SNP	45569682	45569682	10387	1	C	T	T	22	22	MUTYH	T	2	2
INADL	10207	broad.mit.edu	36	1	62039994	62039994	+	Nonsense_Mutation	SNP	T	A	A			TCGA-26-1799-01	TCGA-26-1799-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr1:62039994T>A	uc001dab.1	+	c.1514T>A	c.(1513-1515)TTA>TAA	p.L505*	INADL_uc009waf.1_Nonsense_Mutation_p.L505*|INADL_uc001daa.2_Nonsense_Mutation_p.L505*	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	505					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)	3														0.45	57.347413	57.434157	18	22	TT		KEEP	---	---	---	---	capture			Nonsense_Mutation	SNP	62039994	62039994	8032	1	T	A	A	61	61	INADL	A	5	4
BCAR3	8412	broad.mit.edu	36	1	93827272	93827272	+	Missense_Mutation	SNP	C	T	T			TCGA-26-1799-01	TCGA-26-1799-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:93827272C>T	uc001dpz.1	-	c.779G>A	c.(778-780)CGG>CAG	p.R260Q	BCAR3_uc001dpy.1_Missense_Mutation_p.R169Q|BCAR3_uc001dqa.1_Missense_Mutation_p.R260Q|BCAR3_uc001dqb.1_Missense_Mutation_p.R260Q	NM_003567	NP_003558	O75815	BCAR3_HUMAN	breast cancer antiestrogen resistance 3	260					response to drug|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3		all_lung(203;0.00145)|Lung NSC(277;0.00662)		all cancers(265;0.0126)|GBM - Glioblastoma multiforme(16;0.0467)|Epithelial(280;0.166)										0.833333	33.556243	34.81986	10	2	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	93827272	93827272	1370	1	C	T	T	23	23	BCAR3	T	1	1
DNMT3L	29947	broad.mit.edu	36	21	44495982	44495982	+	Missense_Mutation	SNP	C	T	T			TCGA-26-1799-01	TCGA-26-1799-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr21:44495982C>T	uc002zeh.1	-	c.721G>A	c.(721-723)GTG>ATG	p.V241M	DNMT3L_uc002zeg.1_Missense_Mutation_p.V241M	NM_013369	NP_037501	Q9UJW3	DNM3L_HUMAN	cytosine-5-methyltransferase 3-like protein	241					DNA methylation|regulation of gene expression by genetic imprinting|spermatogenesis	cytosol	enzyme activator activity|enzyme binding|transcription repressor activity|zinc ion binding				0				Colorectal(79;0.0165)|READ - Rectum adenocarcinoma(84;0.0781)										0.555556	123.001749	123.194883	40	32	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	44495982	44495982	4861	21	C	T	T	17	17	DNMT3L	T	2	2
LCT	3938	broad.mit.edu	36	2	136278808	136278808	+	Missense_Mutation	SNP	T	A	A			TCGA-26-1799-01	TCGA-26-1799-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr2:136278808T>A	uc002tuu.1	-	c.4463A>T	c.(4462-4464)CAG>CTG	p.Q1488L		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	1488	Extracellular (Potential).|4.|4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|lung(1)|pancreas(1)	11				BRCA - Breast invasive adenocarcinoma(221;0.169)										0.166667	8.261807	13.336463	8	40	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	136278808	136278808	9017	2	T	A	A	55	55	LCT	A	4	4
ALS2CR11	151254	broad.mit.edu	36	2	202174819	202174819	+	Missense_Mutation	SNP	C	T	T			TCGA-26-1799-01	TCGA-26-1799-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr2:202174819C>T	uc002uyf.1	-	c.404G>A	c.(403-405)CGC>CAC	p.R135H	ALS2CR11_uc002uye.1_Missense_Mutation_p.R135H|ALS2CR11_uc010fti.1_Missense_Mutation_p.R135H	NM_152525	NP_689738	Q53TS8	AL2SA_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	135										large_intestine(1)|ovary(1)	2														0.232558	23.629019	26.445011	10	33	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	202174819	202174819	555	2	C	T	T	27	27	ALS2CR11	T	1	1
TRAT1	50852	broad.mit.edu	36	3	110032317	110032317	+	Missense_Mutation	SNP	G	T	T			TCGA-26-1799-01	TCGA-26-1799-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr3:110032317G>T	uc003dxi.1	+	c.118G>T	c.(118-120)GAT>TAT	p.D40Y	TRAT1_uc010hpx.1_Intron	NM_016388	NP_057472	Q6PIZ9	TRAT1_HUMAN	T-cell receptor interacting molecule	40	Cytoplasmic (Potential).				cellular defense response|negative regulation of receptor recycling|negative regulation of transport|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	phosphatidylinositol-4,5-bisphosphate 3-kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity				0														0.386667	172.317283	174.004545	58	92	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	110032317	110032317	17010	3	G	T	T	35	35	TRAT1	T	3	3
SI	6476	broad.mit.edu	36	3	166265882	166265882	+	Missense_Mutation	SNP	G	C	C			TCGA-26-1799-01	TCGA-26-1799-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr3:166265882G>C	uc003fei.1	-	c.668C>G	c.(667-669)TCT>TGT	p.S223C		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	223	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|pancreas(1)	8		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)									0.3	28.16239	29.235106	9	21	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	166265882	166265882	14792	3	G	C	C	33	33	SI	C	3	3
FAT4	79633	broad.mit.edu	36	4	126461477	126461477	+	Missense_Mutation	SNP	A	T	T			TCGA-26-1799-01	TCGA-26-1799-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr4:126461477A>T	uc003ifj.2	+	c.4461A>T	c.(4459-4461)GAA>GAT	p.E1487D	FAT4_uc003ifh.2_Missense_Mutation_p.E1487D	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4	1487	Cadherin 14.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(8)|pancreas(2)	10														0.121951	17.843011	35.063621	15	108	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	126461477	126461477	5928	4	A	T	T	4	4	FAT4	T	4	4
TLR2	7097	broad.mit.edu	36	4	154845232	154845232	+	Missense_Mutation	SNP	G	T	T			TCGA-26-1799-01	TCGA-26-1799-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr4:154845232G>T	uc003inq.1	+	c.1723G>T	c.(1723-1725)GTT>TTT	p.V575F	TLR2_uc003inr.1_Missense_Mutation_p.V575F|TLR2_uc003ins.1_Missense_Mutation_p.V575F|TLR2_uc010ipt.1_Missense_Mutation_p.V575F	NM_003264	NP_003255	O60603	TLR2_HUMAN	toll-like receptor 2	575	Extracellular (Potential).				cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of gene-specific transcription from RNA polymerase II promoter|positive regulation of inflammatory response|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding				0	all_hematologic(180;0.093)	Renal(120;0.117)												0.457944	148.963313	149.127355	49	58	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	154845232	154845232	16481	4	G	T	T	44	44	TLR2	T	3	3
NPY5R	4889	broad.mit.edu	36	4	164491059	164491059	+	Missense_Mutation	SNP	A	G	G			TCGA-26-1799-01	TCGA-26-1799-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr4:164491059A>G	uc003iqn.1	+	c.184A>G	c.(184-186)ATT>GTT	p.I62V	NPY5R_uc003iqo.2_Missense_Mutation_p.I62V	NM_006174	NP_006165	Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	62	Helical; Name=1; (Potential).				cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane					0	all_hematologic(180;0.166)	Prostate(90;0.109)				Melanoma(139;1287 1774 9781 19750 25599)								0.444444	203.086149	203.471492	64	80	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	164491059	164491059	11015	4	A	G	G	16	16	NPY5R	G	4	4
NEIL3	55247	broad.mit.edu	36	4	178480727	178480727	+	Missense_Mutation	SNP	C	T	T			TCGA-26-1799-01	TCGA-26-1799-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr4:178480727C>T	uc003iut.2	+	c.277C>T	c.(277-279)CGG>TGG	p.R93W	NEIL3_uc010irs.1_Intron	NM_018248	NP_060718	Q8TAT5	NEIL3_HUMAN	nei endonuclease VIII-like 3	93					base-excision repair|nucleotide-excision repair	nucleus	bubble DNA binding|damaged DNA binding|DNA N-glycosylase activity|DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA binding|single-stranded DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Breast(14;6.27e-05)|Melanoma(52;0.00102)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.164)		all cancers(43;1.96e-23)|Epithelial(43;2.52e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.89e-11)|GBM - Glioblastoma multiforme(59;9.49e-05)|Colorectal(24;0.00013)|COAD - Colon adenocarcinoma(29;0.000696)|STAD - Stomach adenocarcinoma(60;0.00308)|LUSC - Lung squamous cell carcinoma(193;0.0398)|READ - Rectum adenocarcinoma(43;0.191)										0.24186	138.626708	151.670828	52	163	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	178480727	178480727	10719	4	C	T	T	19	19	NEIL3	T	1	1
SULT1E1	6783	broad.mit.edu	36	4	70744508	70744508	+	Silent	SNP	G	A	A			TCGA-26-1799-01	TCGA-26-1799-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr4:70744508G>A	uc003heo.1	-	c.732C>T	c.(730-732)GAC>GAT	p.D244D		NM_005420	NP_005411	P49888	ST1E1_HUMAN	sulfotransferase, estrogen-preferring	244					3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol|nuclear membrane	estrone sulfotransferase activity|flavonol 3-sulfotransferase activity|steroid binding|steroid sulfotransferase activity			ovary(1)	1														0.169951	145.527307	187.441065	69	337	GG		KEEP	---	---	---	---	capture			Silent	SNP	70744508	70744508	15900	4	G	A	A	40	40	SULT1E1	A	1	1
HPSE	10855	broad.mit.edu	36	4	84449045	84449045	+	Silent	SNP	G	A	A			TCGA-26-1799-01	TCGA-26-1799-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr4:84449045G>A	uc003hoj.2	-	c.1068C>T	c.(1066-1068)TCC>TCT	p.S356S	HPSE_uc010ika.1_Silent_p.S298S|HPSE_uc003hok.2_Silent_p.S356S	NM_001098540	NP_006656	Q9Y251	HPSE_HUMAN	heparanase	356					carbohydrate metabolic process|proteoglycan metabolic process	extracellular region|lysosomal membrane	beta-glucuronidase activity|cation binding			ovary(1)	1		Hepatocellular(203;0.114)		COAD - Colon adenocarcinoma(81;0.141)	Heparin(DB01109)									0.75	10.928738	11.154309	3	1	GG		KEEP	---	---	---	---	capture			Silent	SNP	84449045	84449045	7636	4	G	A	A	39	39	HPSE	A	1	1
SLCO6A1	133482	broad.mit.edu	36	5	101862436	101862436	+	Silent	SNP	G	A	A			TCGA-26-1799-01	TCGA-26-1799-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr5:101862436G>A	uc003knn.2	-	c.12C>T	c.(10-12)GGC>GGT	p.G4G	SLCO6A1_uc003kno.2_Silent_p.G4G|SLCO6A1_uc003knp.1_Silent_p.G4G|SLCO6A1_uc003knq.1_Silent_p.G4G	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	4	Cytoplasmic (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|central_nervous_system(1)	4		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)										0.538462	65.587459	65.639526	21	18	GG		KEEP	---	---	---	---	capture			Silent	SNP	101862436	101862436	15229	5	G	A	A	38	38	SLCO6A1	A	1	1
FSTL4	23105	broad.mit.edu	36	5	132573836	132573836	+	Missense_Mutation	SNP	G	T	T			TCGA-26-1799-01	TCGA-26-1799-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr5:132573836G>T	uc003kyn.1	-	c.1662C>A	c.(1660-1662)GAC>GAA	p.D554E	FSTL4_uc003kym.1_Missense_Mutation_p.D203E	NM_015082	NP_055897	Q6MZW2	FSTL4_HUMAN	follistatin-like 4	554						extracellular region	calcium ion binding			central_nervous_system(1)	1		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)											0.272727	265.84293	283.226872	102	272	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	132573836	132573836	6330	5	G	T	T	44	44	FSTL4	T	3	3
SEC24A	10802	broad.mit.edu	36	5	134072343	134072343	+	Missense_Mutation	SNP	G	C	C			TCGA-26-1799-01	TCGA-26-1799-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr5:134072343G>C	uc003kzs.1	+	c.2593G>C	c.(2593-2595)GAT>CAT	p.D865H		NM_021982	NP_068817	O95486	SC24A_HUMAN	SEC24 related gene family, member A	865					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)											0.471483	406.57634	406.762441	124	139	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	134072343	134072343	14480	5	G	C	C	41	41	SEC24A	C	3	3
PCDHGA5	56110	broad.mit.edu	36	5	140726308	140726308	+	Missense_Mutation	SNP	G	A	A			TCGA-26-1799-01	TCGA-26-1799-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr5:140726308G>A	uc003lju.1	+	c.2227G>A	c.(2227-2229)GTG>ATG	p.V743M	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003ljt.1_Missense_Mutation_p.V743M	NM_018918	NP_061741	Q9Y5G8	PCDG5_HUMAN	protocadherin gamma subfamily A, 5 isoform 1	743	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)											0.75	46.831796	47.969465	15	5	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	140726308	140726308	11977	5	G	A	A	40	40	PCDHGA5	A	1	1
TNIP1	10318	broad.mit.edu	36	5	150396644	150396644	+	Missense_Mutation	SNP	G	A	A			TCGA-26-1799-01	TCGA-26-1799-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr5:150396644G>A	uc003ltf.1	-	c.1295C>T	c.(1294-1296)CCG>CTG	p.P432L	TNIP1_uc010jhl.1_Non-coding_Transcript|TNIP1_uc010jhm.1_Missense_Mutation_p.P432L|TNIP1_uc010jhn.1_Missense_Mutation_p.P432L|TNIP1_uc003lth.1_Non-coding_Transcript|TNIP1_uc003lti.1_Missense_Mutation_p.P432L|TNIP1_uc003ltg.1_Missense_Mutation_p.P379L|TNIP1_uc003ltj.1_Missense_Mutation_p.P432L|TNIP1_uc010jho.1_Non-coding_Transcript|TNIP1_uc010jhp.1_Missense_Mutation_p.P379L|TNIP1_uc010jhq.1_Missense_Mutation_p.P379L|TNIP1_uc010jhr.1_Missense_Mutation_p.P432L|TNIP1_uc003ltk.2_Missense_Mutation_p.P432L	NM_006058	NP_006049	Q15025	TNIP1_HUMAN	TNFAIP3 interacting protein 1	432	Potential.				defense response|glycoprotein biosynthetic process|negative regulation of viral genome replication|translation	cytoplasm|nucleus	protein binding			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(196;0.0911)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)											0.517986	226.989533	227.028227	72	67	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	150396644	150396644	16855	5	G	A	A	39	39	TNIP1	A	1	1
SH3PXD2B	285590	broad.mit.edu	36	5	171699498	171699498	+	Missense_Mutation	SNP	A	C	C			TCGA-26-1799-01	TCGA-26-1799-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr5:171699498A>C	uc003mbr.1	-	c.1216T>G	c.(1216-1218)TGG>GGG	p.W406G		NM_001017995	NP_001017995	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	406	SH3 3.				adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			ovary(3)	3	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)											0.214286	6.41718	7.47298	3	11	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	171699498	171699498	14749	5	A	C	C	6	6	SH3PXD2B	C	4	4
CPLX2	10814	broad.mit.edu	36	5	175238357	175238357	+	Silent	SNP	C	T	T			TCGA-26-1799-01	TCGA-26-1799-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr5:175238357C>T	uc003mde.1	+	c.9C>T	c.(7-9)TTC>TTT	p.F3F	CPLX2_uc003mdf.1_Silent_p.F3F	NM_006650	NP_006641	Q6PUV4	CPLX2_HUMAN	complexin 2	3					mast cell degranulation|vesicle docking involved in exocytosis	cytosol				ovary(1)	1	all_cancers(89;0.004)|Renal(175;0.000269)|Lung NSC(126;0.00441)|all_lung(126;0.00747)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)											0.55814	76.007821	76.123915	24	19	CC		KEEP	---	---	---	---	capture			Silent	SNP	175238357	175238357	3943	5	C	T	T	31	31	CPLX2	T	1	1
C5orf39	389289	broad.mit.edu	36	5	43075858	43075858	+	Silent	SNP	T	A	A			TCGA-26-1799-01	TCGA-26-1799-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr5:43075858T>A	uc003jnf.1	-	c.48A>T	c.(46-48)GCA>GCT	p.A16A	C5orf39_uc010ivj.1_Non-coding_Transcript|LOC153684_uc003jng.1_5'Flank|LOC153684_uc003jni.1_5'Flank	NM_001014279	NP_001014301	Q3ZCQ2	AX2R_HUMAN	annexin II receptor	16							receptor activity				0												OREG0016598	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0.292683	32.786639	34.362779	12	29	TT		KEEP	---	---	---	---	capture			Silent	SNP	43075858	43075858	2395	5	T	A	A	55	55	C5orf39	A	4	4
SV2C	22987	broad.mit.edu	36	5	75656991	75656991	+	Missense_Mutation	SNP	G	A	A			TCGA-26-1799-01	TCGA-26-1799-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr5:75656991G>A	uc003kei.1	+	c.2047G>A	c.(2047-2049)GTC>ATC	p.V683I		NM_014979	NP_055794	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	683	Helical; (Potential).				neurotransmitter transport|transmembrane transport	cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			skin(1)	1		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)										0.38674	200.787817	202.82783	70	111	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	75656991	75656991	15939	5	G	A	A	40	40	SV2C	A	1	1
F13A1	2162	broad.mit.edu	36	6	6211853	6211853	+	Missense_Mutation	SNP	C	T	T			TCGA-26-1799-01	TCGA-26-1799-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr6:6211853C>T	uc003mwv.1	-	c.508G>A	c.(508-510)GTA>ATA	p.V170I		NM_000129	NP_000120	P00488	F13A_HUMAN	coagulation factor XIII A1 subunit precursor	170					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)									0.211832	269.402437	309.588824	111	413	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	6211853	6211853	5534	6	C	T	T	19	19	F13A1	T	1	1
CYP3A43	64816	broad.mit.edu	36	7	99291272	99291272	+	Nonsense_Mutation	SNP	C	T	T			TCGA-26-1799-01	TCGA-26-1799-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr7:99291272C>T	uc003ury.1	+	c.793C>T	c.(793-795)CAA>TAA	p.Q265*	CYP3A43_uc003urx.1_Nonsense_Mutation_p.Q265*|CYP3A43_uc003urz.1_Nonsense_Mutation_p.Q265*|CYP3A43_uc003usa.1_Non-coding_Transcript|CYP3A43_uc010lgi.1_Nonsense_Mutation_p.Q155*|CYP3A43_uc003usb.1_Intron	NM_022820	NP_073731	Q9HB55	CP343_HUMAN	cytochrome P450, family 3, subfamily A,	265			Missing (in allele CYP3A43*2).		oxidation-reduction process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)	1	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)				Cetirizine(DB00341)|Doxycycline(DB00254)									0.363636	31.887391	32.428618	12	21	CC		KEEP	---	---	---	---	capture			Nonsense_Mutation	SNP	99291272	99291272	4344	7	C	T	T	17	17	CYP3A43	T	5	2
ZMAT4	79698	broad.mit.edu	36	8	40802286	40802286	+	Silent	SNP	G	A	A			TCGA-26-1799-01	TCGA-26-1799-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr8:40802286G>A	uc003xnr.1	-	c.67C>T	c.(67-69)CTG>TTG	p.L23L	ZMAT4_uc003xns.1_Silent_p.L23L	NM_024645	NP_078921	Q9H898	ZMAT4_HUMAN	zinc finger, matrin type 4 isoform a	23	Matrin-type 1.					nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2	Ovarian(28;0.00724)|Colorectal(14;0.0468)	all_cancers(7;0.00936)|all_epithelial(6;3.53e-06)|all_lung(54;0.0318)|Lung NSC(58;0.0919)|Esophageal squamous(32;0.15)|Hepatocellular(245;0.152)	LUSC - Lung squamous cell carcinoma(45;0.00722)											0.545455	18.02249	18.039934	6	5	GG		KEEP	---	---	---	---	capture			Silent	SNP	40802286	40802286	18285	8	G	A	A	34	34	ZMAT4	A	2	2
OR13C8	138802	broad.mit.edu	36	9	106371285	106371285	+	Missense_Mutation	SNP	G	A	A			TCGA-26-1799-01	TCGA-26-1799-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr9:106371285G>A	uc004bcc.1	+	c.16G>A	c.(16-18)GAT>AAT	p.D6N		NM_001004483	NP_001004483	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C,	6	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1														0.27027	82.208914	87.488694	30	81	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	106371285	106371285	11344	9	G	A	A	37	37	OR13C8	A	1	1
FAM47A	158724	broad.mit.edu	36	X	34059191	34059191	+	Missense_Mutation	SNP	G	A	A			TCGA-26-1799-01	TCGA-26-1799-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chrX:34059191G>A	uc004ddg.1	-	c.1126C>T	c.(1126-1128)CAC>TAC	p.H376Y		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	376										ovary(4)|central_nervous_system(1)	5														0.191781	28.307363	34.789084	14	59	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	34059191	34059191	5790	23	G	A	A	47	47	FAM47A	A	2	2
PAGE5	90737	broad.mit.edu	36	X	55264982	55264982	+	Missense_Mutation	SNP	G	T	T			TCGA-26-1799-01	TCGA-26-1799-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chrX:55264982G>T	uc004duj.1	+	c.199G>T	c.(199-201)GGT>TGT	p.G67C	PAGE5_uc004duk.1_Missense_Mutation_p.G47C	NM_130467	NP_001013453	Q96GU1	GGEE1_HUMAN	P antigen family, member 5 isoform 1	67											0														0.545455	39.701967	39.741617	12	10	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	55264982	55264982	11809	23	G	T	T	43	43	PAGE5	T	3	3
RLIM	51132	broad.mit.edu	36	X	73728373	73728373	+	Missense_Mutation	SNP	G	A	A			TCGA-26-1799-01	TCGA-26-1799-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chrX:73728373G>A	uc004ebv.1	-	c.1502C>T	c.(1501-1503)TCA>TTA	p.S501L	RLIM_uc004ebu.1_5'Flank|RLIM_uc004ebx.1_Missense_Mutation_p.S501L|RLIM_uc004ebw.1_Missense_Mutation_p.S501L	NM_183353	NP_899196	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	501	Ser-rich.|Poly-Ser.				random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding	p.S501L(1)		ovary(2)	2						Esophageal Squamous(169;1899 1923 14997 18818 32118)								0.214286	6.617175	7.67272	3	11	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	73728373	73728373	13867	23	G	A	A	45	45	RLIM	A	2	2
TET1	80312	broad.mit.edu	36	10	70003169	70003169	+	Frame_Shift_Del	DEL	G	-	-			TCGA-26-1799-01	TCGA-26-1799-01										Phase_I	Unspecified				Illumina GAIIx	g.chr10:70003169_70003169delG	uc001jok.2	+	c.1068_1068delG	c.(1066-1068)CAGfs	p.Q356fs		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	356					DNA demethylation|inner cell mass cell differentiation|oxidation-reduction process|stem cell maintenance	nucleus	iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)	5										280				0.77			54	16				---	---	---	---	capture_indel			Frame_Shift_Del	DEL	70003169	70003169	16296	10	G	-	-	35	35	TET1	-	5	5
ZNF778	197320	broad.mit.edu	36	16	87822055	87822055	+	Frame_Shift_Del	DEL	A	-	-			TCGA-26-1799-01	TCGA-26-1799-01										Phase_I	Unspecified				Illumina GAIIx	g.chr16:87822055_87822055delA	uc002fmv.2	+	c.1774_1774delA	c.(1774-1776)AAAfs	p.K592fs	ZNF778_uc002fmw.1_Frame_Shift_Del_p.K550fs	NM_182531	NP_872337	Q96MU6	ZN778_HUMAN	zinc finger protein 778	592	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(80;0.0269)										0.33			2	4				---	---	---	---	capture_indel			Frame_Shift_Del	DEL	87822055	87822055	18749	16	A	-	-	13	13	ZNF778	-	5	5
SCAF1	58506	broad.mit.edu	36	19	54846122	54846123	+	Frame_Shift_Ins	INS	-	C	C			TCGA-26-1799-01	TCGA-26-1799-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:54846122_54846123insC	uc002poq.1	+	c.664_665insC	c.(664-666)GCCfs	p.A222fs	SCAF1_uc002por.1_Frame_Shift_Ins_p.A222fs	NM_021228	NP_067051	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	222	Pro-rich.				mRNA processing|RNA splicing	nucleus	RNA binding				0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)										0.33			3	6				---	---	---	---	capture_indel			Frame_Shift_Ins	INS	54846122	54846123	14349	19	-	C	C	46	46	SCAF1	C	5	5
ASAP3	55616	broad.mit.edu	36	1	23641678	23641681	+	Frame_Shift_Del	DEL	TTCT	-	-			TCGA-26-1799-01	TCGA-26-1799-01										Phase_I	Unspecified				Illumina GAIIx	g.chr1:23641678_23641681delTTCT	uc001bha.1	-	c.485_488delAGAA	c.(484-489)GAGAAGfs	p.E162fs	ASAP3_uc001bhc.1_Frame_Shift_Del_p.E162fs	NM_017707	NP_060177	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	162_163	Potential.				regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)	2														0.33			13	26				---	---	---	---	capture_indel			Frame_Shift_Del	DEL	23641678	23641681	1030	1	TTCT	-	-	56	56	ASAP3	-	5	5
MKL1	57591	broad.mit.edu	36	22	39145315	39145315	+	Frame_Shift_Del	DEL	T	-	-			TCGA-26-1799-01	TCGA-26-1799-01										Phase_I	Unspecified				Illumina GAIIx	g.chr22:39145315_39145315delT	uc003ayv.1	-	c.1073_1073delA	c.(1072-1074)GAGfs	p.E358fs	MKL1_uc003ayw.1_Frame_Shift_Del_p.E358fs|MKL1_uc010gye.1_Frame_Shift_Del_p.E358fs|MKL1_uc010gyf.1_Frame_Shift_Del_p.E308fs	NM_020831	NP_065882	Q969V6	MKL1_HUMAN	megakaryoblastic leukemia 1 protein	358	SAP.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|nucleic acid binding|transcription coactivator activity			ovary(2)|central_nervous_system(1)	3										210				0.33			4	8				---	---	---	---	capture_indel			Frame_Shift_Del	DEL	39145315	39145315	9991	22	T	-	-	54	54	MKL1	-	5	5
SLITRK3	22865	broad.mit.edu	36	3	166390334	166390342	+	In_Frame_Del	DEL	TGTATTCGA	-	-			TCGA-26-1799-01	TCGA-26-1799-01										Phase_I	Unspecified				Illumina GAIIx	g.chr3:166390334_166390342delTGTATTCGA	uc003fej.2	-	c.971_979delTCGAATACA	c.(970-981)GTCGAATACAAG>GAG	p.324_327VEYK>E	SLITRK3_uc003fek.1_In_Frame_Del_p.324_327VEYK>E|SLITRK3_uc010hwj.1_In_Frame_Del_p.324_327VEYK>E	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein	324_327	Extracellular (Potential).					integral to membrane				ovary(6)|pancreas(1)	7														0.55			29	24				---	---	---	---	capture_indel			In_Frame_Del	DEL	166390334	166390342	15242	3	TGTATTCGA	-	-	63	63	SLITRK3	-	5	5
EZR	7430	broad.mit.edu	36	6	159110352	159110355	+	Frame_Shift_Del	DEL	CTGC	-	-			TCGA-26-1799-01	TCGA-26-1799-01										Phase_I	Unspecified				Illumina GAIIx	g.chr6:159110352_159110355delCTGC	uc003qrt.2	-	c.1335_1338delGCAG	c.(1333-1338)TGGCAGfs	p.W445fs	EZR_uc003qru.2_Frame_Shift_Del_p.W445fs	NM_003379	NP_003370	P15311	EZRI_HUMAN	ezrin	445_446	Interaction with SCYL3.				actin filament bundle assembly|axon guidance|cytoskeletal anchoring at plasma membrane|leukocyte cell-cell adhesion|membrane to membrane docking|regulation of cell shape	actin filament|apical plasma membrane|basolateral plasma membrane|cortical cytoskeleton|cytosol|extrinsic to membrane|filopodium|microvillus membrane|nucleolus|ruffle membrane	actin filament binding|cell adhesion molecule binding			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-17)|BRCA - Breast invasive adenocarcinoma(81;6.58e-06)										0.69			146	66				---	---	---	---	capture_indel			Frame_Shift_Del	DEL	159110352	159110355	5529	6	CTGC	-	-	28	28	EZR	-	5	5
BTN2A1	11120	broad.mit.edu	36	6	26576509	26576509	+	Frame_Shift_Del	DEL	C	-	-			TCGA-26-1799-01	TCGA-26-1799-01										Phase_I	Unspecified				Illumina GAIIx	g.chr6:26576509_26576509delC	uc003nib.1	+	c.1337_1337delC	c.(1336-1338)TCCfs	p.S446fs	BTN2A1_uc003nic.1_3'UTR|BTN2A1_uc003nid.1_Frame_Shift_Del_p.S294fs|BTN2A1_uc010jqk.1_Frame_Shift_Del_p.S206fs	NM_007049	NP_008980	Q7KYR7	BT2A1_HUMAN	butyrophilin, subfamily 2, member A1 isoform 1	446	Cytoplasmic (Potential).|B30.2/SPRY.				lipid metabolic process	integral to plasma membrane				ovary(1)	1														0.43			83	108				---	---	---	---	capture_indel			Frame_Shift_Del	DEL	26576509	26576509	1594	6	C	-	-	30	30	BTN2A1	-	5	5
NPDC1	56654	broad.mit.edu	36	9	139057254	139057258	+	Frame_Shift_Del	DEL	GCTGA	-	-			TCGA-26-1799-01	TCGA-26-1799-01										Phase_I	Unspecified				Illumina GAIIx	g.chr9:139057254_139057258delGCTGA	uc004cks.1	-	c.435_439delTCAGC	c.(433-441)CTTCAGCCCfs	p.L145fs	NPDC1_uc004ckr.1_Frame_Shift_Del_p.L67fs|NPDC1_uc004ckt.1_Frame_Shift_Del_p.L67fs|NPDC1_uc004cku.1_Frame_Shift_Del_p.L67fs	NM_015392	NP_056207	Q9NQX5	NPDC1_HUMAN	neural proliferation, differentiation and	67_69						integral to membrane					0	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.96e-05)|Epithelial(140;0.000486)										0.75			9	3				---	---	---	---	capture_indel			Frame_Shift_Del	DEL	139057254	139057258	10977	9	GCTGA	-	-	42	42	NPDC1	-	5	5
