Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	i_TCGAscape_Amplification_Peaks	i_TCGAscape_Deletion_Peaks	DrugBank	i_ACHILLES_Top_Genes	i_CCLE_ONCOMAP_overlapping_mutations	i_CCLE_ONCOMAP_total_mutations_in_gene	i_CCLE_SEQ_overlapping_mutations	i_CCLE_SEQ_total_mutations_in_gene	MUTSIG_Significant_Genes	OREGANNO_ID	OREGANNO_Values	i_tumor_f	i_init_t_lod	i_t_lod_fstar	i_t_alt_count	i_t_ref_count	i_normal_best_gt	i_failure_reasons	i_judgement	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	dataset	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	type	classification	start	end	gene	chr	ref_allele	tum_allele1	tum_allele2	context_orig	context65	gene_name	newbase	categ	categ_ignoring_null_categ
MYO3A	53904	broad.mit.edu	36	10	26505753	26505753	+	Nonsense_Mutation	SNP	C	T	T			TCGA-28-2501-01	TCGA-28-2501-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr10:26505753C>T	uc001isn.2	+	c.4411C>T	c.(4411-4413)CGA>TGA	p.R1471*	MYO3A_uc009xkp.1_Intron|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1471					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|lung(3)|central_nervous_system(2)|breast(1)|kidney(1)|pancreas(1)	14										781				0.2	19.249802	23.01653	9	36	CC		KEEP	---	---	---	---	capture			Nonsense_Mutation	SNP	26505753	26505753	10471	10	C	T	T	19	19	MYO3A	T	5	1
OR5D16	390144	broad.mit.edu	36	11	55362935	55362935	+	Silent	SNP	T	C	C			TCGA-28-2501-01	TCGA-28-2501-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr11:55362935T>C	uc001nhz.1	+	c.132T>C	c.(130-132)AAT>AAC	p.N44N		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D,	44	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3		all_epithelial(135;0.208)												0.130952	19.283849	30.391975	11	73	TT		KEEP	---	---	---	---	capture			Silent	SNP	55362935	55362935	11566	11	T	C	C	50	50	OR5D16	C	4	4
OR5AR1	219493	broad.mit.edu	36	11	56188264	56188264	+	Missense_Mutation	SNP	A	G	G			TCGA-28-2501-01	TCGA-28-2501-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr11:56188264A>G	uc001njc.1	+	c.527A>G	c.(526-528)CAT>CGT	p.H176R		NM_001004730	NP_001004730	Q8NGP9	O5AR1_HUMAN	olfactory receptor, family 5, subfamily AR,	176	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0														0.180556	28.438042	35.340699	13	59	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	56188264	56188264	11555	11	A	G	G	8	8	OR5AR1	G	4	4
CHD8	57680	broad.mit.edu	36	14	20967034	20967034	+	Nonsense_Mutation	SNP	G	A	A			TCGA-28-2501-01	TCGA-28-2501-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr14:20967034G>A	uc001was.1	-	c.307C>T	c.(307-309)CAG>TAG	p.Q103*	CHD8_uc001war.1_5'UTR	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	382	Gln-rich.				ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|chromatin assembly or disassembly|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	chromatin|MLL1 complex	ATP binding|beta-catenin binding|chromatin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding|transcription activator activity|transcription repressor activity			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)									886				0.127451	13.695997	27.512347	13	89	GG		KEEP	---	---	---	---	capture	Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)	Nonsense_Mutation	SNP	20967034	20967034	3465	14	G	A	A	45	45	CHD8	A	5	2
DNAH9	1770	broad.mit.edu	36	17	11591671	11591671	+	Missense_Mutation	SNP	C	T	T			TCGA-28-2501-01	TCGA-28-2501-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr17:11591671C>T	uc002gne.1	+	c.6473C>T	c.(6472-6474)TCA>TTA	p.S2158L	DNAH9_uc010coo.1_Missense_Mutation_p.S1452L	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2158	AAA 2 (By similarity).|ATP (Potential).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	10		Breast(5;0.0122)|all_epithelial(5;0.131)												0.12766	7.015746	13.370628	6	41	CC		KEEP	---	---	---	---	capture		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)	Missense_Mutation	SNP	11591671	11591671	4791	17	C	T	T	29	29	DNAH9	T	2	2
ATPAF2	91647	broad.mit.edu	36	17	17882990	17882990	+	Silent	SNP	A	C	C			TCGA-28-2501-01	TCGA-28-2501-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr17:17882990A>C	uc002gse.1	-	c.63T>G	c.(61-63)GGT>GGG	p.G21G	ATPAF2_uc002gsd.1_Non-coding_Transcript|ATPAF2_uc002gsf.1_Non-coding_Transcript|C17orf39_uc002gsg.1_5'Flank	NM_145691	NP_663729	Q8N5M1	ATPF2_HUMAN	ATP synthase mitochondrial F1 complex assembly	21					proton-transporting ATP synthase complex assembly	mitochondrion|nuclear speck	protein binding				0	all_neural(463;0.228)													0.666667	10.024202	10.211291	6	3	AA		KEEP	---	---	---	---	capture			Silent	SNP	17882990	17882990	1220	17	A	C	C	6	6	ATPAF2	C	4	4
ITGB3	3690	broad.mit.edu	36	17	42731747	42731747	+	Missense_Mutation	SNP	C	T	T			TCGA-28-2501-01	TCGA-28-2501-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr17:42731747C>T	uc002ilj.1	+	c.1765C>T	c.(1765-1767)CGT>TGT	p.R589C		NM_000212	NP_000203	P05106	ITB3_HUMAN	integrin beta chain, beta 3 precursor	589	Extracellular (Potential).|III.|Cysteine-rich tandem repeats.				activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			central_nervous_system(5)|large_intestine(1)	6					Abciximab(DB00054)|Tirofiban(DB00775)									0.1875	23.962563	29.815384	12	52	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	42731747	42731747	8199	17	C	T	T	27	27	ITGB3	T	1	1
SPAG9	9043	broad.mit.edu	36	17	46417313	46417313	+	Missense_Mutation	SNP	C	T	T			TCGA-28-2501-01	TCGA-28-2501-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr17:46417313C>T	uc002itc.1	-	c.3058G>A	c.(3058-3060)GGC>AGC	p.G1020S	SPAG9_uc002ita.1_Missense_Mutation_p.G355S|SPAG9_uc002itb.1_Missense_Mutation_p.G1006S|SPAG9_uc002itd.1_Missense_Mutation_p.G1010S	NM_003971	NP_003962	O60271	JIP4_HUMAN	sperm associated antigen 9 isoform 3	1020					positive regulation of cell migration|positive regulation of muscle cell differentiation|retrograde transport, endosome to Golgi|spermatogenesis	acrosomal vesicle|integral to membrane|perinuclear region of cytoplasm				lung(1)	1														0.161017	35.744325	48.571835	19	99	CC		KEEP	---	---	---	---	capture	BRCA - Breast invasive adenocarcinoma(22;4.24e-07)		Missense_Mutation	SNP	46417313	46417313	15488	17	C	T	T	23	23	SPAG9	T	1	1
CD300LB	124599	broad.mit.edu	36	17	70033594	70033594	+	Silent	SNP	C	T	T			TCGA-28-2501-01	TCGA-28-2501-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr17:70033594C>T	uc002jkx.2	-	c.369G>A	c.(367-369)ACG>ACA	p.T123T		NM_174892	NP_777552	A8K4G0	CLM7_HUMAN	CD300 molecule-like family member b	86	Ig-like V-type.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(1)	1														0.131387	24.561456	42.651694	18	119	CC		KEEP	---	---	---	---	capture			Silent	SNP	70033594	70033594	3127	17	C	T	T	19	19	CD300LB	T	1	1
EVPL	2125	broad.mit.edu	36	17	71516862	71516862	+	Missense_Mutation	SNP	G	A	A			TCGA-28-2501-01	TCGA-28-2501-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr17:71516862G>A	uc002jqi.2	-	c.4019C>T	c.(4018-4020)GCG>GTG	p.A1340V		NM_001988	NP_001979	Q92817	EVPL_HUMAN	envoplakin	1340	Central fibrous rod domain.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			pancreas(2)|central_nervous_system(1)	3														0.223214	49.793768	57.637742	25	87	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	71516862	71516862	5485	17	G	A	A	38	38	EVPL	A	1	1
ENGASE	64772	broad.mit.edu	36	17	74585392	74585392	+	Silent	SNP	G	T	T			TCGA-28-2501-01	TCGA-28-2501-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr17:74585392G>T	uc002jwv.1	+	c.267G>T	c.(265-267)TCG>TCT	p.S89S	ENGASE_uc002jwu.1_Silent_p.S89S|ENGASE_uc002jww.1_5'Flank	NM_001042573	NP_001036038	Q8NFI3	ENASE_HUMAN	endo-beta-N-acetylglucosaminidase	89						cytosol	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity				0														0.155556	26.292715	36.489413	14	76	GG		KEEP	---	---	---	---	capture			Silent	SNP	74585392	74585392	5311	17	G	T	T	38	38	ENGASE	T	3	3
DNAH2	146754	broad.mit.edu	36	17	7583804	7583804	+	Missense_Mutation	SNP	G	A	A			TCGA-28-2501-01	TCGA-28-2501-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr17:7583804G>A	uc002giu.1	+	c.1199G>A	c.(1198-1200)CGC>CAC	p.R400H	DNAH2_uc002git.2_Missense_Mutation_p.R482H	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	400	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|central_nervous_system(1)	7		all_cancers(10;4.66e-07)|Prostate(122;0.081)												0.242424	16.437986	18.483822	8	25	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	7583804	7583804	4785	17	G	A	A	38	38	DNAH2	A	1	1
VN1R4	317703	broad.mit.edu	36	19	58462506	58462506	+	Silent	SNP	G	A	A	rs3097257	unknown	TCGA-28-2501-01	TCGA-28-2501-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr19:58462506G>A	uc002qbj.1	-	c.225C>T	c.(223-225)CTC>CTT	p.L75L		NM_173857	NP_776256	Q7Z5H5	VN1R4_HUMAN	vomeronasal 1 receptor 4	75	Extracellular (Potential).				response to pheromone	actin cytoskeleton|cytoplasm|integral to membrane|plasma membrane	pheromone receptor activity			ovary(2)	2														0.16	6.68265	9.436138	4	21	GG		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(134;0.00294)	Silent	SNP	58462506	58462506	17747	19	G	A	A	45	45	VN1R4	A	2	2
DENND1C	79958	broad.mit.edu	36	19	6430059	6430059	+	Missense_Mutation	SNP	G	A	A			TCGA-28-2501-01	TCGA-28-2501-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr19:6430059G>A	uc002mfe.1	-	c.185C>T	c.(184-186)CCC>CTC	p.P62L	DENND1C_uc002mfb.1_5'Flank|DENND1C_uc002mfc.1_5'Flank|DENND1C_uc002mfd.1_5'UTR	NM_024898	NP_079174	Q8IV53	DEN1C_HUMAN	DENN/MADD domain containing 1C	62	UDENN.					clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			large_intestine(1)	1														0.16	24.061758	32.309108	12	63	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	6430059	6430059	4607	19	G	A	A	43	43	DENND1C	A	2	2
FLG	2312	broad.mit.edu	36	1	150549534	150549534	+	Silent	SNP	G	A	A	rs71626706	unknown	TCGA-28-2501-01	TCGA-28-2501-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:150549534G>A	uc001ezu.1	-	c.4452C>T	c.(4450-4452)GAC>GAT	p.D1484D		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1484	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)	9	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)													0.161209	110.078159	153.41592	64	333	GG		KEEP	---	---	---	---	capture	LUSC - Lung squamous cell carcinoma(543;0.206)		Silent	SNP	150549534	150549534	6160	1	G	A	A	40	40	FLG	A	1	1
HMCN1	83872	broad.mit.edu	36	1	184223295	184223295	+	Missense_Mutation	SNP	C	G	G			TCGA-28-2501-01	TCGA-28-2501-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:184223295C>G	uc001grq.1	+	c.3044C>G	c.(3043-3045)TCC>TGC	p.S1015C	HMCN1_uc001grr.1_Missense_Mutation_p.S356C	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1	1015	Ig-like C2-type 7.				bioluminescence|protein-chromophore linkage|response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)	22														0.131579	9.551694	14.560994	5	33	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	184223295	184223295	7511	1	C	G	G	30	30	HMCN1	G	3	3
TPR	7175	broad.mit.edu	36	1	184556133	184556133	+	Missense_Mutation	SNP	G	A	A			TCGA-28-2501-01	TCGA-28-2501-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:184556133G>A	uc001grv.1	-	c.6502C>T	c.(6502-6504)CCA>TCA	p.P2168S		NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	2168					carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)							p.P2168S(SKNDZ-Tumor)|p.P2168S(UACC812-Tumor)|p.P2168S(KYSE140-Tumor)|p.P2168S(NCIH1963-Tumor)|p.P2168S(NALM1-Tumor)	1949				0.6	9.425683	9.469352	3	2	GG		KEEP	---	---	---	---	capture		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)	Missense_Mutation	SNP	184556133	184556133	16960	1	G	A	A	42	42	TPR	A	2	2
RBBP5	5929	broad.mit.edu	36	1	203332507	203332507	+	Missense_Mutation	SNP	G	A	A			TCGA-28-2501-01	TCGA-28-2501-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:203332507G>A	uc001hbu.1	-	c.1322C>T	c.(1321-1323)TCA>TTA	p.S441L	RBBP5_uc001hbv.1_Missense_Mutation_p.S441L	NM_005057	NP_005048	Q15291	RBBP5_HUMAN	retinoblastoma binding protein 5	441					histone H3-K4 methylation|regulation of transcription, DNA-dependent|response to estrogen stimulus|transcription, DNA-dependent	MLL1 complex|Set1C/COMPASS complex	promoter binding|protein binding			lung(1)	1	Breast(84;0.0505)													0.181818	46.013297	58.581673	24	108	GG		KEEP	---	---	---	---	capture	BRCA - Breast invasive adenocarcinoma(75;0.0923)		Missense_Mutation	SNP	203332507	203332507	13563	1	G	A	A	45	45	RBBP5	A	2	2
KCNK1	3775	broad.mit.edu	36	1	231869023	231869023	+	Missense_Mutation	SNP	G	A	A			TCGA-28-2501-01	TCGA-28-2501-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:231869023G>A	uc001hvv.1	+	c.415G>A	c.(415-417)GTC>ATC	p.V139I	KCNK1_uc001hvw.1_Non-coding_Transcript|KCNK1_uc001hvx.1_Non-coding_Transcript	NM_002245	NP_002236	O00180	KCNK1_HUMAN	potassium channel, subfamily K, member 1	139	Helical; (Potential).					voltage-gated potassium channel complex	inward rectifier potassium channel activity			central_nervous_system(1)	1		all_cancers(173;0.00217)|all_epithelial(177;0.121)|Prostate(94;0.122)|Acute lymphoblastic leukemia(190;0.175)			Ibutilide(DB00308)|Quinidine(DB00908)									0.305556	27.911192	29.125498	11	25	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	231869023	231869023	8363	1	G	A	A	40	40	KCNK1	A	1	1
HEATR1	55127	broad.mit.edu	36	1	234794464	234794464	+	Missense_Mutation	SNP	G	T	T			TCGA-28-2501-01	TCGA-28-2501-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:234794464G>T	uc001hyd.1	-	c.4556C>A	c.(4555-4557)TCC>TAC	p.S1519Y	HEATR1_uc009xgh.1_Missense_Mutation_p.S681Y	NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	1519					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)	2	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)												0.181818	11.228653	14.36902	6	27	GG		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(106;0.00117)		Missense_Mutation	SNP	234794464	234794464	7310	1	G	T	T	41	41	HEATR1	T	3	3
NLRP3	114548	broad.mit.edu	36	1	245654465	245654465	+	Missense_Mutation	SNP	G	A	A			TCGA-28-2501-01	TCGA-28-2501-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:245654465G>A	uc001icr.1	+	c.1097G>A	c.(1096-1098)CGG>CAG	p.R366Q	NLRP3_uc001ics.1_Missense_Mutation_p.R366Q|NLRP3_uc001ict.1_Missense_Mutation_p.R364Q|NLRP3_uc001icu.1_Missense_Mutation_p.R366Q|NLRP3_uc001icw.1_Missense_Mutation_p.R366Q|NLRP3_uc001icv.1_Missense_Mutation_p.R366Q	NM_001079821	NP_004886	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	366	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			ovary(5)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	11	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)								412				0.157895	19.620433	28.165098	12	64	GG		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(106;0.0141)		Missense_Mutation	SNP	245654465	245654465	10881	1	G	A	A	39	39	NLRP3	A	1	1
SCMH1	22955	broad.mit.edu	36	1	41287109	41287109	+	Silent	SNP	G	A	A			TCGA-28-2501-01	TCGA-28-2501-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:41287109G>A	uc001cgo.1	-	c.1116C>T	c.(1114-1116)CAC>CAT	p.H372H	SCMH1_uc001cgp.1_Silent_p.H311H|SCMH1_uc001cgr.1_Silent_p.H311H|SCMH1_uc001cgs.1_Silent_p.H382H|SCMH1_uc001cgt.1_Silent_p.H311H|SCMH1_uc001cgq.1_Silent_p.H325H	NM_001031694	NP_001026864	Q96GD3	SCMH1_HUMAN	sex comb on midleg 1 isoform 1	372					anatomical structure morphogenesis|gene silencing|multicellular organismal development|negative regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription repressor activity				0	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)|Breast(333;0.162)	Myeloproliferative disorder(586;0.0393)												0.139535	17.475922	28.244085	12	74	GG		KEEP	---	---	---	---	capture			Silent	SNP	41287109	41287109	14390	1	G	A	A	36	36	SCMH1	A	2	2
CPT2	1376	broad.mit.edu	36	1	53438984	53438984	+	Missense_Mutation	SNP	C	T	T			TCGA-28-2501-01	TCGA-28-2501-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr1:53438984C>T	uc001cvb.2	+	c.158C>T	c.(157-159)CCT>CTT	p.P53L		NM_000098	NP_000089	P23786	CPT2_HUMAN	carnitine O-palmitoyltransferase precursor	53	Mitochondrial matrix (By similarity).				carnitine shuttle|fatty acid beta-oxidation|regulation of fatty acid oxidation	mitochondrial inner membrane	carnitine O-palmitoyltransferase activity				0					L-Carnitine(DB00583)|Perhexiline(DB01074)									0.2	28.965748	33.987611	12	48	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	53438984	53438984	3973	1	C	T	T	24	24	CPT2	T	2	2
RALGAPB	57148	broad.mit.edu	36	20	36601960	36601960	+	Missense_Mutation	SNP	C	G	G			TCGA-28-2501-01	TCGA-28-2501-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr20:36601960C>G	uc002xiw.1	+	c.2507C>G	c.(2506-2508)GCT>GGT	p.A836G	RALGAPB_uc002xix.1_Missense_Mutation_p.A832G|RALGAPB_uc002xiy.1_Missense_Mutation_p.A836G|RALGAPB_uc002xiz.1_Missense_Mutation_p.A614G|RALGAPB_uc002xja.1_Missense_Mutation_p.A563G	NM_020336	NP_065069	Q86X10	RLGPB_HUMAN	hypothetical protein LOC57148	836					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			pancreas(1)	1														0.214286	6.947008	9.191379	6	22	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	36601960	36601960	13475	20	C	G	G	28	28	RALGAPB	G	3	3
MC3R	4159	broad.mit.edu	36	20	54258225	54258225	+	Missense_Mutation	SNP	C	T	T			TCGA-28-2501-01	TCGA-28-2501-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr20:54258225C>T	uc002xxb.2	+	c.1030C>T	c.(1030-1032)CGC>TGC	p.R344C		NM_019888	NP_063941	P41968	MC3R_HUMAN	melanocortin 3 receptor	344	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			ovary(2)	2														0.166667	30.081574	41.470018	18	90	CC		KEEP	---	---	---	---	capture	Colorectal(105;0.202)		Missense_Mutation	SNP	54258225	54258225	9754	20	C	T	T	27	27	MC3R	T	1	1
SLCO4A1	28231	broad.mit.edu	36	20	60758516	60758516	+	Missense_Mutation	SNP	T	G	G			TCGA-28-2501-01	TCGA-28-2501-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr20:60758516T>G	uc002ydb.1	+	c.265T>G	c.(265-267)TGG>GGG	p.W89G	SLCO4A1_uc002ydc.1_Non-coding_Transcript	NM_016354	NP_057438	Q96BD0	SO4A1_HUMAN	solute carrier organic anion transporter family	89	Cytoplasmic (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(1)	1	Breast(26;3.65e-08)					Pancreas(168;741 2006 10379 40139 45334)				402				0.357143	6.33014	6.59788	5	9	TT		KEEP	---	---	---	---	capture	BRCA - Breast invasive adenocarcinoma(19;2.33e-06)		Missense_Mutation	SNP	60758516	60758516	15226	20	T	G	G	59	59	SLCO4A1	G	4	4
C21orf29	54084	broad.mit.edu	36	21	44772857	44772857	+	Silent	SNP	C	T	T			TCGA-28-2501-01	TCGA-28-2501-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr21:44772857C>T	uc002zfe.1	-	c.828G>A	c.(826-828)CCG>CCA	p.P276P	C21orf29_uc010gpv.1_Silent_p.P208P	NM_144991	NP_659428	Q8WU66	TSEAR_HUMAN	chromosome 21 open reading frame 29	276					cell adhesion	extracellular region	structural molecule activity				0														0.15873	17.460908	24.412818	10	53	CC		KEEP	---	---	---	---	capture			Silent	SNP	44772857	44772857	2204	21	C	T	T	19	19	C21orf29	T	1	1
MYO18B	84700	broad.mit.edu	36	22	24558907	24558907	+	Missense_Mutation	SNP	C	A	A			TCGA-28-2501-01	TCGA-28-2501-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr22:24558907C>A	uc003abz.1	+	c.3003C>A	c.(3001-3003)GAC>GAA	p.D1001E	MYO18B_uc003aca.1_Missense_Mutation_p.D882E|MYO18B_uc010guy.1_Missense_Mutation_p.D882E|MYO18B_uc010guz.1_Missense_Mutation_p.D882E	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1001	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12										968				0.148148	13.161921	19.582215	8	46	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	24558907	24558907	10461	22	C	A	A	18	18	MYO18B	A	3	3
DOCK10	55619	broad.mit.edu	36	2	225378406	225378406	+	Missense_Mutation	SNP	T	C	C			TCGA-28-2501-01	TCGA-28-2501-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr2:225378406T>C	uc010fwz.1	-	c.3899A>G	c.(3898-3900)AAT>AGT	p.N1300S	DOCK10_uc002vob.2_Missense_Mutation_p.N1294S	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1300							GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)												0.1875	7.742048	9.184643	3	13	TT		KEEP	---	---	---	---	capture		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)	Missense_Mutation	SNP	225378406	225378406	4869	2	T	C	C	52	52	DOCK10	C	4	4
EPHB1	2047	broad.mit.edu	36	3	136334439	136334439	+	Silent	SNP	C	A	A			TCGA-28-2501-01	TCGA-28-2501-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr3:136334439C>A	uc003eqt.1	+	c.1155C>A	c.(1153-1155)GGC>GGA	p.G385G	EPHB1_uc010htz.1_Non-coding_Transcript|EPHB1_uc003equ.1_5'UTR	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	385	Extracellular (Potential).|Fibronectin type-III 1.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(7)|ovary(4)|stomach(3)|central_nervous_system(2)|large_intestine(1)|pancreas(1)	18										376				0.233333	11.437399	13.471757	7	23	CC		KEEP	---	---	---	---	capture			Silent	SNP	136334439	136334439	5367	3	C	A	A	26	26	EPHB1	A	3	3
HTR3E	285242	broad.mit.edu	36	3	185306776	185306776	+	Silent	SNP	G	A	A			TCGA-28-2501-01	TCGA-28-2501-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr3:185306776G>A	uc010hxr.1	+	c.1170G>A	c.(1168-1170)GCG>GCA	p.A390A	HTR3E_uc010hxq.1_Silent_p.A364A|HTR3E_uc003fml.2_Silent_p.A349A|HTR3E_uc003fmm.1_Silent_p.A379A|HTR3E_uc003fmn.1_Silent_p.A364A	NM_182589	NP_872395	A5X5Y0	5HT3E_HUMAN	5-hydroxytryptamine receptor 3 subunit E	364	Cytoplasmic (Potential).					integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			ovary(1)|central_nervous_system(1)	2	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)					Melanoma(7;227 727 6634 44770)								0.25	10.667455	11.802814	5	15	GG		KEEP	---	---	---	---	capture	Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)		Silent	SNP	185306776	185306776	7748	3	G	A	A	38	38	HTR3E	A	1	1
DGKG	1608	broad.mit.edu	36	3	187458391	187458391	+	Missense_Mutation	SNP	G	A	A			TCGA-28-2501-01	TCGA-28-2501-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr3:187458391G>A	uc003fqa.1	-	c.1456C>T	c.(1456-1458)CGT>TGT	p.R486C	DGKG_uc003fqb.1_Missense_Mutation_p.R447C|DGKG_uc003fqc.1_Missense_Mutation_p.R461C	NM_001346	NP_001337	P49619	DGKG_HUMAN	diacylglycerol kinase gamma isoform 1	486	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(2)|central_nervous_system(1)|skin(1)	4	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)				Phosphatidylserine(DB00144)					546				0.215686	26.300211	30.102466	11	40	GG		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Missense_Mutation	SNP	187458391	187458391	4648	3	G	A	A	39	39	DGKG	A	1	1
BDH1	622	broad.mit.edu	36	3	198723310	198723310	+	Silent	SNP	C	T	T			TCGA-28-2501-01	TCGA-28-2501-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr3:198723310C>T	uc003fxr.1	-	c.885G>A	c.(883-885)ACG>ACA	p.T295T	BDH1_uc003fxs.1_Silent_p.T295T|BDH1_uc003fxt.1_Silent_p.T208T|BDH1_uc003fxu.1_Silent_p.T295T	NM_203314	NP_976060	Q02338	BDH_HUMAN	3-hydroxybutyrate dehydrogenase, type 1	295					cellular lipid metabolic process|ketone body biosynthetic process|ketone body catabolic process|oxidation-reduction process	mitochondrial matrix	3-hydroxybutyrate dehydrogenase activity			ovary(1)	1	all_cancers(143;3.35e-10)|Ovarian(172;0.0418)|Breast(254;0.0437)	Lung NSC(153;0.118)			NADH(DB00157)									0.118421	9.085616	19.903159	9	67	CC		KEEP	---	---	---	---	capture	Epithelial(36;3.52e-24)|all cancers(36;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(49;2.32e-19)|LUSC - Lung squamous cell carcinoma(58;1.02e-06)|Lung(62;1.34e-06)	GBM - Glioblastoma multiforme(93;0.0977)	Silent	SNP	198723310	198723310	1412	3	C	T	T	19	19	BDH1	T	1	1
FHDC1	85462	broad.mit.edu	36	4	154115497	154115499	+	Indel	Indel	--A	CC	CC			TCGA-28-2501-01	TCGA-28-2501-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr4:154115499A>C	uc003inf.2	+	c.1606A>C	c.(1606-1608)ACC>CCC	p.T536P		NM_033393	NP_203751	Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	536					actin cytoskeleton organization		actin binding			large_intestine(1)|ovary(1)	2	all_hematologic(180;0.093)													0.5	6.650615	6.650609	2	2	AA		KEEP	---	---	---	---	capture			Indel	Indel	154115497	154115499	6114	4	--A	CC	CC	2	2	FHDC1	CC	5	5
LIAS	11019	broad.mit.edu	36	4	39141600	39141600	+	Missense_Mutation	SNP	A	C	C			TCGA-28-2501-01	TCGA-28-2501-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr4:39141600A>C	uc003guf.1	+	c.373A>C	c.(373-375)ACC>CCC	p.T125P	LIAS_uc003gue.2_Missense_Mutation_p.T125P|LIAS_uc003gug.1_Missense_Mutation_p.T125P|LIAS_uc003guh.1_Missense_Mutation_p.T125P	NM_006859	NP_006850	O43766	LIAS_HUMAN	lipoic acid synthetase isoform 1 precursor	125					inflammatory response|response to lipopolysaccharide|response to oxidative stress	mitochondrion	4 iron, 4 sulfur cluster binding|lipoate synthase activity|metal ion binding				0					Lipoic Acid(DB00166)									0.263158	8.16029	9.131337	5	14	AA		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	39141600	39141600	9104	4	A	C	C	6	6	LIAS	C	4	4
AMBN	258	broad.mit.edu	36	4	71506943	71506943	+	Silent	SNP	G	A	A			TCGA-28-2501-01	TCGA-28-2501-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr4:71506943G>A	uc003hfl.1	+	c.1251G>A	c.(1249-1251)ACG>ACA	p.T417T		NM_016519	NP_057603	Q9NP70	AMBN_HUMAN	ameloblastin precursor	417					bone mineralization|cell adhesion|cell proliferation|odontogenesis of dentine-containing tooth	proteinaceous extracellular matrix	growth factor activity|structural constituent of tooth enamel			ovary(3)	3														0.163636	16.939555	22.851636	9	46	GG		KEEP	---	---	---	---	capture	Lung(101;0.235)		Silent	SNP	71506943	71506943	566	4	G	A	A	37	37	AMBN	A	1	1
ABLIM3	22885	broad.mit.edu	36	5	148597245	148597245	+	Silent	SNP	G	T	T			TCGA-28-2501-01	TCGA-28-2501-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr5:148597245G>T	uc003lpy.2	+	c.930G>T	c.(928-930)GCG>GCT	p.A310A	ABLIM3_uc003lpz.1_Silent_p.A310A|ABLIM3_uc003lqa.1_Intron|ABLIM3_uc003lqb.2_Intron|ABLIM3_uc003lqc.1_Silent_p.A310A|ABLIM3_uc003lqd.1_Intron|ABLIM3_uc003lqf.2_Intron|ABLIM3_uc003lqe.1_Intron	NM_014945	NP_055760	O94929	ABLM3_HUMAN	actin binding LIM protein family, member 3	310					axon guidance|cytoskeleton organization	cytoplasm	actin binding|zinc ion binding			ovary(2)	2														0.202381	39.741356	46.642226	17	67	GG		KEEP	---	---	---	---	capture	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Silent	SNP	148597245	148597245	97	5	G	T	T	39	39	ABLIM3	T	3	3
CMYA5	202333	broad.mit.edu	36	5	79062302	79062302	+	Missense_Mutation	SNP	T	C	C			TCGA-28-2501-01	TCGA-28-2501-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr5:79062302T>C	uc003kgc.1	+	c.1958T>C	c.(1957-1959)CTC>CCC	p.L653P		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	653						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)												0.15625	9.37041	12.967491	5	27	TT		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)	Missense_Mutation	SNP	79062302	79062302	3728	5	T	C	C	54	54	CMYA5	C	4	4
MDC1	9656	broad.mit.edu	36	6	30790850	30790850	+	Missense_Mutation	SNP	C	T	T			TCGA-28-2501-01	TCGA-28-2501-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr6:30790850C>T	uc003nrg.2	-	c.82G>A	c.(82-84)GTG>ATG	p.V28M	MDC1_uc003nrf.2_5'Flank|MDC1_uc003nrh.1_De_novo_Start_OutOfFrame|MDC1_uc003nri.1_Missense_Mutation_p.V28M	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA damage checkpoint 1	28	Interaction with the MRN complex.|Interaction with CHEK2.				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4														0.193548	22.162285	27.601025	12	50	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	30790850	30790850	9792	6	C	T	T	19	19	MDC1	T	1	1
CNTNAP2	26047	broad.mit.edu	36	7	146628253	146628253	+	Missense_Mutation	SNP	C	T	T			TCGA-28-2501-01	TCGA-28-2501-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr7:146628253C>T	uc003weu.1	+	c.1436C>T	c.(1435-1437)GCA>GTA	p.A479V		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	479	Extracellular (Potential).|Laminin G-like 2.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)												0.156863	12.464265	18.19801	8	43	CC		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(82;0.0319)		Missense_Mutation	SNP	146628253	146628253	3785	7	C	T	T	25	25	CNTNAP2	T	2	2
TNKS	8658	broad.mit.edu	36	8	9450989	9450989	+	Missense_Mutation	SNP	A	C	C			TCGA-28-2501-01	TCGA-28-2501-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr8:9450989A>C	uc003wss.1	+	c.130A>C	c.(130-132)ACC>CCC	p.T44P		NM_003747	NP_003738	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related	44					mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein transport|spindle assembly|transmembrane transport	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			ovary(1)|kidney(1)	2														0.285714	6.331424	7.281507	6	15	AA		KEEP	---	---	---	---	capture		COAD - Colon adenocarcinoma(149;0.0467)	Missense_Mutation	SNP	9450989	9450989	16860	8	A	C	C	6	6	TNKS	C	4	4
ANKS6	203286	broad.mit.edu	36	9	100573120	100573120	+	Silent	SNP	G	A	A			TCGA-28-2501-01	TCGA-28-2501-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr9:100573120G>A	uc004ayu.1	-	c.1851C>T	c.(1849-1851)AGC>AGT	p.S617S	ANKS6_uc004ayt.1_Silent_p.S316S|ANKS6_uc004ayv.1_Silent_p.S79S|ANKS6_uc004ayw.1_Silent_p.S199S|ANKS6_uc004ayx.1_Non-coding_Transcript|ANKS6_uc004ayy.1_Non-coding_Transcript	NM_173551	NP_775822	Q68DC2	ANKS6_HUMAN	ankyrin repeat and sterile alpha motif domain	617	Ser-rich.									ovary(2)	2		Acute lymphoblastic leukemia(62;0.0527)												0.178571	9.257103	11.98156	5	23	GG		KEEP	---	---	---	---	capture			Silent	SNP	100573120	100573120	700	9	G	A	A	42	42	ANKS6	A	2	2
BRD3	8019	broad.mit.edu	36	9	135908255	135908255	+	Missense_Mutation	SNP	C	T	T			TCGA-28-2501-01	TCGA-28-2501-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr9:135908255C>T	uc004cew.1	-	c.166G>A	c.(166-168)GCC>ACC	p.A56T	BRD3_uc004cex.1_Missense_Mutation_p.A56T	NM_007371	NP_031397	Q15059	BRD3_HUMAN	bromodomain containing protein 3	56	Bromo 1.					nucleus	protein binding		BRD3/C15orf55(3)	stomach(4)|midline_organs(3)|kidney(1)	8										497				0.153846	13.786836	19.727927	8	44	CC		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(145;1.43e-08)|Epithelial(140;8.41e-08)|all cancers(34;5.21e-07)	Missense_Mutation	SNP	135908255	135908255	1534	9	C	T	T	27	27	BRD3	T	1	1
LCN12	286256	broad.mit.edu	36	9	138966667	138966667	+	Missense_Mutation	SNP	A	C	C			TCGA-28-2501-01	TCGA-28-2501-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr9:138966667A>C	uc004ckb.1	+	c.67A>C	c.(67-69)ACC>CCC	p.T23P	LCN12_uc004ckc.2_Missense_Mutation_p.T23P	NM_178536	NP_848631	Q6JVE5	LCN12_HUMAN	lipocalcin 12	23					lipid metabolic process	extracellular region	binding|transporter activity				0	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)												0.3	7.821142	8.178515	3	7	AA		KEEP	---	---	---	---	capture	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;7.8e-06)|Epithelial(140;0.000106)	Missense_Mutation	SNP	138966667	138966667	9006	9	A	C	C	2	2	LCN12	C	4	4
FRMPD1	22844	broad.mit.edu	36	9	37730490	37730490	+	Silent	SNP	C	T	T			TCGA-28-2501-01	TCGA-28-2501-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr9:37730490C>T	uc004aag.1	+	c.1965C>T	c.(1963-1965)TTC>TTT	p.F655F	FRMPD1_uc004aah.1_Silent_p.F655F	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	655						cytoskeleton|cytosol|plasma membrane				ovary(4)|central_nervous_system(2)|breast(1)	7														0.166667	6.596058	9.116249	4	20	CC		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(29;0.00655)	Silent	SNP	37730490	37730490	6307	9	C	T	T	30	30	FRMPD1	T	2	2
DOCK8	81704	broad.mit.edu	36	9	394947	394947	+	Silent	SNP	G	A	A			TCGA-28-2501-01	TCGA-28-2501-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr9:394947G>A	uc003zgf.1	+	c.3264G>A	c.(3262-3264)ACG>ACA	p.T1088T	DOCK8_uc003zgi.1_Silent_p.T1020T|DOCK8_uc010mgu.1_Silent_p.T390T|DOCK8_uc010mgv.1_Silent_p.T988T|DOCK8_uc010mgw.1_Silent_p.T390T|DOCK8_uc003zgk.1_Silent_p.T546T	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1088					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)												0.185185	10.064462	12.569415	5	22	GG		KEEP	---	---	---	---	capture		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)	Silent	SNP	394947	394947	4877	9	G	A	A	38	38	DOCK8	A	1	1
FMR1NB	158521	broad.mit.edu	36	X	146896022	146896022	+	Missense_Mutation	SNP	C	T	T			TCGA-28-2501-01	TCGA-28-2501-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chrX:146896022C>T	uc004fcm.1	+	c.506C>T	c.(505-507)ACG>ATG	p.T169M		NM_152578	NP_689791	Q8N0W7	FMR1N_HUMAN	fragile X mental retardation 1 neighbor	169	P-type.|Extracellular (Potential).					integral to membrane				ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)													0.333333	38.438353	39.470404	14	28	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	146896022	146896022	6203	23	C	T	T	19	19	FMR1NB	T	1	1
KCNN2	3781	broad.mit.edu	36	5	113726530	113726531	+	In_Frame_Ins	INS	-	GCC	GCC			TCGA-28-2501-01	TCGA-28-2501-01										Phase_I	Unspecified				Illumina GAIIx	g.chr5:113726530_113726531insGCC	uc003kqo.1	+	c.159_160insGCC	c.(157-162)insGCC	p.58_59insA		NM_021614	NP_067627	Q9H2S1	KCNN2_HUMAN	small conductance calcium-activated potassium	58_59						integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			ovary(2)	2		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)										0.38			3	5				---	---	---	---	capture_indel			In_Frame_Ins	INS	113726530	113726531	8384	5	-	GCC	GCC	55	55	KCNN2	GCC	5	5
