Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	i_TCGAscape_Amplification_Peaks	i_TCGAscape_Deletion_Peaks	DrugBank	i_ACHILLES_Top_Genes	i_CCLE_ONCOMAP_overlapping_mutations	i_CCLE_ONCOMAP_total_mutations_in_gene	i_CCLE_SEQ_overlapping_mutations	i_CCLE_SEQ_total_mutations_in_gene	MUTSIG_Significant_Genes	OREGANNO_ID	OREGANNO_Values	i_tumor_f	i_init_t_lod	i_t_lod_fstar	i_t_alt_count	i_t_ref_count	i_normal_best_gt	i_failure_reasons	i_judgement	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	dataset	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	type	classification	start	end	gene	chr	ref_allele	tum_allele1	tum_allele2	context_orig	context65	gene_name	newbase	categ	categ_ignoring_null_categ
SLC39A12	221074	broad.mit.edu	36	10	18316544	18316544	+	Silent	SNP	C	T	T			TCGA-76-4934-01	TCGA-76-4934-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr10:18316544C>T	uc001ipo.1	+	c.1227C>T	c.(1225-1227)GTC>GTT	p.V409V	SLC39A12_uc001ipn.1_Silent_p.V409V|SLC39A12_uc001ipp.1_Silent_p.V409V	NM_152725	NP_689938	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	409	Helical; (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2														0.715116	402.594537	409.745574	123	49	CC		KEEP	---	---	---	---	capture			Silent	SNP	18316544	18316544	15112	10	C	T	T	31	31	SLC39A12	T	1	1
PTEN	5728	broad.mit.edu	36	10	89682758	89682758	+	Missense_Mutation	SNP	T	C	C			TCGA-76-4934-01	TCGA-76-4934-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr10:89682758T>C	uc001kfb.1	+	c.262T>C	c.(262-264)TAT>CAT	p.Y88H		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	88	Phosphatase tensin-type.				apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of focal adhesion assembly|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of cyclin-dependent protein kinase activity|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.Y27_N212>Y(2)|p.Y88N(1)|p.Y88H(1)|p.Q87_P96del(1)|p.N82_P95del(1)|p.F56fs*2(1)		endometrium(831)|central_nervous_system(654)|skin(119)|haematopoietic_and_lymphoid_tissue(101)|prostate(97)|large_intestine(90)|breast(67)|lung(63)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(21)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(12)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2308		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)						31		264	TCGA GBM(2;<1E-8)|TSP Lung(26;0.18)			0.808696	355.748831	365.994818	93	22	TT		KEEP	---	---	---	---	capture	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)	Missense_Mutation	SNP	89682758	89682758	13192	10	T	C	C	49	49	PTEN	C	4	4
DCDC1	341019	broad.mit.edu	36	11	30930671	30930671	+	Missense_Mutation	SNP	C	T	T			TCGA-76-4934-01	TCGA-76-4934-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr11:30930671C>T	uc001msu.1	-	c.1469G>A	c.(1468-1470)GGA>GAA	p.G490E				P59894	DCDC1_HUMAN	cDNA FLJ44078 fis, clone TESTI4039038.	Error:Variant_position_missing_in_P59894_after_alignment					intracellular signal transduction						0	Lung SC(675;0.225)													0.68	56.09222	56.82181	17	8	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	30930671	30930671	4455	11	C	T	T	30	30	DCDC1	T	2	2
ART4	420	broad.mit.edu	36	12	14884819	14884819	+	Missense_Mutation	SNP	G	A	A			TCGA-76-4934-01	TCGA-76-4934-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr12:14884819G>A	uc001rcl.1	-	c.680C>T	c.(679-681)ACC>ATC	p.T227I	ART4_uc009zid.1_Intron|ART4_uc009zie.1_Intron|ART4_uc001rcm.1_Missense_Mutation_p.T227I	NM_021071	NP_066549	Q93070	NAR4_HUMAN	ADP-ribosyltransferase 4 precursor	227					arginine metabolic process|protein ADP-ribosylation	anchored to membrane|plasma membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity				0														0.337838	138.298509	141.743276	50	98	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	14884819	14884819	1017	12	G	A	A	44	44	ART4	A	2	2
KDM5A	5927	broad.mit.edu	36	12	287240	287240	+	Missense_Mutation	SNP	G	A	A			TCGA-76-4934-01	TCGA-76-4934-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr12:287240G>A	uc001qif.1	-	c.3571C>T	c.(3571-3573)CTT>TTT	p.L1191F	KDM5A_uc001qie.1_Missense_Mutation_p.L1191F	NM_001042603	NP_001036068	P29375	KDM5A_HUMAN	retinoblastoma binding protein 2 isoform 1	1191	PHD-type 2.				chromatin modification|multicellular organismal development|oxidation-reduction process|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|transcription activator activity|zinc ion binding			skin(2)|ovary(1)	3										958				0.167247	99.705578	129.835432	48	239	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	287240	287240	8439	12	G	A	A	33	33	KDM5A	A	2	2
KRT75	9119	broad.mit.edu	36	12	51108402	51108402	+	Silent	SNP	C	G	G			TCGA-76-4934-01	TCGA-76-4934-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr12:51108402C>G	uc001saj.2	-	c.1287G>C	c.(1285-1287)CGG>CGC	p.R429R		NM_004693	NP_004684	O95678	K2C75_HUMAN	keratin 75	429	Coil 2.|Rod.					keratin filament	structural molecule activity				0														0.173077	11.931241	17.20692	9	43	CC		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(357;0.192)	Silent	SNP	51108402	51108402	8803	12	C	G	G	26	26	KRT75	G	3	3
KRT73	319101	broad.mit.edu	36	12	51298141	51298141	+	Silent	SNP	G	A	A			TCGA-76-4934-01	TCGA-76-4934-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr12:51298141G>A	uc001sas.1	-	c.435C>T	c.(433-435)TCC>TCT	p.S145S		NM_175068	NP_778238	Q86Y46	K2C73_HUMAN	keratin 73	145	Coil 1A.|Rod.					keratin filament	structural molecule activity			large_intestine(2)|ovary(2)	4														0.395652	284.974997	287.167093	91	139	GG		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(357;0.189)	Silent	SNP	51298141	51298141	8801	12	G	A	A	35	35	KRT73	A	2	2
LRIG3	121227	broad.mit.edu	36	12	57560799	57560799	+	Silent	SNP	A	G	G			TCGA-76-4934-01	TCGA-76-4934-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr12:57560799A>G	uc001sqr.1	-	c.1632T>C	c.(1630-1632)GCT>GCC	p.A544A	LRIG3_uc009zqh.1_Silent_p.A484A	NM_153377	NP_700356	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like	544	Ig-like C2-type 1.					integral to membrane				ovary(1)|skin(1)	2														0.404651	249.673073	251.383823	87	128	AA		KEEP	---	---	---	---	capture	GBM - Glioblastoma multiforme(1;1.17e-18)		Silent	SNP	57560799	57560799	9319	12	A	G	G	7	7	LRIG3	G	4	4
TNFRSF1A	7132	broad.mit.edu	36	12	6312898	6312898	+	Missense_Mutation	SNP	G	T	T			TCGA-76-4934-01	TCGA-76-4934-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr12:6312898G>T	uc001qnu.1	-	c.368C>A	c.(367-369)ACC>AAC	p.T123N	TNFRSF1A_uc001qnt.1_Missense_Mutation_p.T15N|TNFRSF1A_uc009zek.1_Missense_Mutation_p.T80N	NM_001065	NP_001056	P19438	TNR1A_HUMAN	tumor necrosis factor receptor 1 precursor	123	TNFR-Cys 2.|Extracellular (Potential).				apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|inflammatory response|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of inflammatory response|positive regulation of transcription from RNA polymerase II promoter|prostaglandin metabolic process	extracellular region|integral to plasma membrane|membrane raft	tumor necrosis factor receptor activity			skin(1)	1										109				0.4	97.238288	97.979488	34	51	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	6312898	6312898	16834	12	G	T	T	44	44	TNFRSF1A	T	3	3
NALCN	259232	broad.mit.edu	36	13	100526227	100526227	+	Missense_Mutation	SNP	G	A	A			TCGA-76-4934-01	TCGA-76-4934-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr13:100526227G>A	uc001vox.1	-	c.3952C>T	c.(3952-3954)CAT>TAT	p.H1318Y		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	1318	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)													0.626263	371.715347	374.478914	124	74	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	100526227	100526227	10544	13	G	A	A	48	48	NALCN	A	2	2
TPTE2	93492	broad.mit.edu	36	13	18937688	18937688	+	Nonsense_Mutation	SNP	G	A	A			TCGA-76-4934-01	TCGA-76-4934-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr13:18937688G>A	uc001umd.1	-	c.529C>T	c.(529-531)CGA>TGA	p.R177*	TPTE2_uc001ume.1_Nonsense_Mutation_p.R100*|TPTE2_uc009zzl.1_Nonsense_Mutation_p.R66*|TPTE2_uc009zzm.1_5'UTR|TPTE2_uc009zzk.1_Non-coding_Transcript	NM_199254	NP_954863	Q6XPS3	TPTE2_HUMAN	TPTE and PTEN homologous inositol lipid	177						endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)												0.246377	42.948559	46.984068	17	52	GG		KEEP	---	---	---	---	capture		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)	Nonsense_Mutation	SNP	18937688	18937688	16975	13	G	A	A	37	37	TPTE2	A	5	1
MPHOSPH8	54737	broad.mit.edu	36	13	19133946	19133946	+	Missense_Mutation	SNP	G	A	A			TCGA-76-4934-01	TCGA-76-4934-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr13:19133946G>A	uc001umg.2	+	c.1900G>A	c.(1900-1902)GGG>AGG	p.G634R	MPHOSPH8_uc001umh.1_Missense_Mutation_p.G634R	NM_017520	NP_059990	Q99549	MPP8_HUMAN	M-phase phosphoprotein 8	634	ANK 2.				cell cycle|chromatin assembly or disassembly	chromatin|cytoplasm|nucleus	chromatin binding				0		all_cancers(29;2.83e-16)|all_lung(29;1.16e-17)|all_epithelial(30;8.13e-16)|Lung NSC(5;6.91e-15)|Lung SC(185;0.0367)												0.22561	93.032516	104.342859	37	127	GG		KEEP	---	---	---	---	capture		all cancers(112;8.43e-05)|Epithelial(112;0.000426)|OV - Ovarian serous cystadenocarcinoma(117;0.00596)|Lung(94;0.015)|LUSC - Lung squamous cell carcinoma(192;0.0795)	Missense_Mutation	SNP	19133946	19133946	10119	13	G	A	A	39	39	MPHOSPH8	A	1	1
OR4Q3	441669	broad.mit.edu	36	14	19285769	19285770	+	Missense_Mutation	DNP	TT	AG	AG			TCGA-76-4934-01	TCGA-76-4934-01										Phase_I	Unspecified				Illumina GAIIx	g.chr14:19285769_19285770TT>AG	uc001vwe.1	+	c.343_344TT>AG	c.(343-345)TTG>AGG	p.L115R		NM_172194	NP_751944	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q,	115	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)	3	all_cancers(95;0.00108)													0.761905	259.839734	266.415916	80	25	TT		KEEP	---	---	---	---	capture	Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)	Missense_Mutation	DNP	19285769	19285770	11491	14	TT	AG	AG	64	64	OR4Q3	AG	4	4
BATF	10538	broad.mit.edu	36	14	75082594	75082594	+	Missense_Mutation	SNP	C	T	T			TCGA-76-4934-01	TCGA-76-4934-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr14:75082594C>T	uc001xrr.1	+	c.205C>T	c.(205-207)CGC>TGC	p.R69C		NM_006399	NP_006390	Q16520	BATF_HUMAN	basic leucine zipper transcription factor,	69	Leucine-zipper.				regulation of transcription, DNA-dependent	nucleus	protein dimerization activity|RNA polymerase II transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1														0.71875	146.571361	149.322688	46	18	CC		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(234;0.028)	Missense_Mutation	SNP	75082594	75082594	1346	14	C	T	T	19	19	BATF	T	1	1
HEATR3	55027	broad.mit.edu	36	16	48670359	48670359	+	Missense_Mutation	SNP	G	C	C			TCGA-76-4934-01	TCGA-76-4934-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr16:48670359G>C	uc002efw.1	+	c.970G>C	c.(970-972)GAT>CAT	p.D324H	HEATR3_uc002efx.1_Missense_Mutation_p.D238H	NM_182922	NP_891552	Q7Z4Q2	HEAT3_HUMAN	HEAT repeat containing 3	324							binding			ovary(1)	1														0.488095	294.645447	294.666203	82	86	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	48670359	48670359	7312	16	G	C	C	33	33	HEATR3	C	3	3
ZC3H18	124245	broad.mit.edu	36	16	87216191	87216191	+	Nonsense_Mutation	SNP	C	T	T			TCGA-76-4934-01	TCGA-76-4934-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr16:87216191C>T	uc002fky.1	+	c.1561C>T	c.(1561-1563)CGA>TGA	p.R521*	ZC3H18_uc010chw.1_Non-coding_Transcript	NM_144604	NP_653205	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	521						nucleus	nucleic acid binding|zinc ion binding				0						Ovarian(121;375 2276 20373 38669)								0.549296	116.312684	116.461413	39	32	CC		KEEP	---	---	---	---	capture		BRCA - Breast invasive adenocarcinoma(80;0.0542)	Nonsense_Mutation	SNP	87216191	87216191	18156	16	C	T	T	23	23	ZC3H18	T	5	1
TP53	7157	broad.mit.edu	36	17	7517845	7517845	+	Missense_Mutation	SNP	C	T	T	rs28934576	unknown	TCGA-76-4934-01	TCGA-76-4934-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr17:7517845C>T	uc002gim.2	-	c.818G>A	c.(817-819)CGT>CAT	p.R273H	TP53_uc002gig.1_Intron|TP53_uc002gih.1_Missense_Mutation_p.R273H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141H|TP53_uc010cng.1_Missense_Mutation_p.R141H|TP53_uc002gii.1_Missense_Mutation_p.R141H|TP53_uc010cnh.1_Missense_Mutation_p.R273H|TP53_uc010cni.1_Missense_Mutation_p.R273H|TP53_uc002gij.2_Missense_Mutation_p.R273H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of gene-specific transcription from RNA polymerase II promoter|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of gene-specific transcription from RNA polymerase II promoter|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	chromatin|cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|promoter binding|promoter binding|protease binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin protein ligase binding|zinc ion binding	p.R273H(458)|p.R273L(83)|p.R273P(24)|p.0?(6)|p.R273_C275delRVC(1)|p.?(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273S(1)|p.E258fs*71(1)|p.C141fs*29(1)|p.R273fs*72(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.R273fs*33(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4614)|breast(2344)|upper_aerodigestive_tract(2150)|lung(1958)|ovary(1559)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1212)|stomach(1127)|urinary_tract(1113)|central_nervous_system(1072)|liver(805)|skin(693)|pancreas(370)|biliary_tract(247)|soft_tissue(209)|prostate(192)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(41)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	21904		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)				Pancreas(47;798 1329 9957 10801)	R273H(NCIH1793_LUNG)|R273H(MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PANC1_PANCREAS)|R273H(NCIH508_LARGE_INTESTINE)|R273H(NCIH1975_LUNG)|R273H(U251MG_CENTRAL_NERVOUS_SYSTEM)|R273H(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273H(NCIH2405_LUNG)|R273H(HEC59_ENDOMETRIUM)|R273H(NCIH1155_LUNG)|R273H(HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(EN_ENDOMETRIUM)|R273H(SNB19_CENTRAL_NERVOUS_SYSTEM)|R273H(MDAMB468_BREAST)|R273H(SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW620_LARGE_INTESTINE)|R273H(SUIT2_PANCREAS)|R273H(SW480_LARGE_INTESTINE)|R273H(SKMEL30_SKIN)|R273H(OC314_OVARY)|R273H(HEC6_ENDOMETRIUM)|R273H(HT29_LARGE_INTESTINE)	111	p.R273H(SW480-Tumor)|p.R273L(NCIH1876-Tumor)|p.R273H(SW620-Tumor)|p.R273H(MDAMB468-Tumor)|p.R273Y(SW1783-Tumor)|p.R273H(YD8-Tumor)|p.R273L(NCIH1838-Tumor)|p.R273H(HT29-Tumor)|p.R273H(MONOMAC6-Tumor)|p.R273L(SNU503-Tumor)|p.R273H(MOLT13-Tumor)|p.R273Y(PF382-Tumor)|p.R273L(NCIH1734-Tumor)|p.R273H(FTC133-Tumor)|p.R273H(SNU601-Tumor)|p.R273H(NCIH1975-Tumor)|p.R273H(NCIH1793-Tumor)|p.R273L(ECGI10-Tumor)|p.R273H(KP1NL-Tumor)|p.R273H(KP1N-Tumor)|p.R273L(NCIH1623-Tumor)|p.R273L(NCIH2009-Tumor)|p.R273H(NCIH508-Tumor)|p.R273H(MONOMAC1-Tumor)|p.R273H(HEC59-Tumor)|p.R273H(FTC238-Tumor)|p.R273H(OC316-Tumor)|p.R273Y(SNUC2A-Tumor)|p.R273H(SUDHL1-Tumor)|p.R273L(HCC38-Tumor)|p.R273H(NCIH2405-Tumor)|p.R273H(HEC6-Tumor)|p.R273H(EN-Tumor)	690	TCGA GBM(1;<1E-8)|TSP Lung(2;<1E-8)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0.77551	124.773908	128.192123	38	11	CC		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)	Missense_Mutation	SNP	7517845	7517845	16923	17	C	T	T	19	19	TP53	T	1	1
NDC80	10403	broad.mit.edu	36	18	2600820	2600820	+	Missense_Mutation	SNP	G	A	A			TCGA-76-4934-01	TCGA-76-4934-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr18:2600820G>A	uc002kli.1	+	c.1751G>A	c.(1750-1752)CGT>CAT	p.R584H		NM_006101	NP_006092	O14777	NDC80_HUMAN	kinetochore associated 2	584	Potential.|Interaction with the C-terminus of CDCA1 and the SPBC24-SPBC25 subcomplex.|Interaction with NEK2 and ZWINT.				attachment of spindle microtubules to kinetochore|cell division|establishment of mitotic spindle orientation|mitotic prometaphase|mitotic sister chromatid segregation|mitotic spindle organization|phosphatidylinositol-mediated signaling	condensed nuclear chromosome outer kinetochore|cytosol|Ndc80 complex	protein binding			ovary(1)	1														0.425714	439.512493	441.198446	149	201	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	2600820	2600820	10641	18	G	A	A	40	40	NDC80	A	1	1
PCSK4	54760	broad.mit.edu	36	19	1433471	1433471	+	Missense_Mutation	SNP	G	A	A			TCGA-76-4934-01	TCGA-76-4934-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr19:1433471G>A	uc002ltb.1	-	c.1700C>T	c.(1699-1701)ACG>ATG	p.T567M	PCSK4_uc002lsz.2_Missense_Mutation_p.T54M|PCSK4_uc002lta.2_Silent_p.D337D	NM_017573	NP_060043	Q6UW60	PCSK4_HUMAN	proprotein convertase subtilisin/kexin type 4	567					proteolysis	integral to membrane	serine-type endopeptidase activity				0		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)												0.263889	44.989077	48.622004	19	53	GG		KEEP	---	---	---	---	capture		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Missense_Mutation	SNP	1433471	1433471	12023	19	G	A	A	40	40	PCSK4	A	1	1
PSG11	5680	broad.mit.edu	36	19	48215038	48215038	+	Missense_Mutation	SNP	C	G	G			TCGA-76-4934-01	TCGA-76-4934-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr19:48215038C>G	uc002ovn.1	-	c.451G>C	c.(451-453)GAG>CAG	p.E151Q	PSG10_uc002ouv.1_Intron|PSG6_uc002ovi.2_Intron|PSG11_uc002ouw.1_Missense_Mutation_p.E151Q|PSG6_uc002ovh.1_Intron|PSG11_uc002ovk.1_Missense_Mutation_p.E151Q|PSG11_uc002ovm.1_Missense_Mutation_p.E145Q|PSG11_uc002ovo.1_Missense_Mutation_p.E23Q|PSG11_uc002ovp.1_Missense_Mutation_p.E23Q	NM_002785	NP_002776	Q9UQ72	PSG11_HUMAN	pregnancy specific beta-1-glycoprotein 11	145					female pregnancy	extracellular region					0		Prostate(69;0.00682)												0.380846	576.99429	582.592922	171	278	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	48215038	48215038	13107	19	C	G	G	30	30	PSG11	G	3	3
MYBPC2	4606	broad.mit.edu	36	19	55655181	55655181	+	Missense_Mutation	SNP	C	G	G			TCGA-76-4934-01	TCGA-76-4934-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr19:55655181C>G	uc002psf.2	+	c.2864C>G	c.(2863-2865)GCC>GGC	p.A955G		NM_004533	NP_004524	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	955	Fibronectin type-III 3.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)												0.6	6.92021	6.96295	3	2	CC		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)	Missense_Mutation	SNP	55655181	55655181	10407	19	C	G	G	26	26	MYBPC2	G	3	3
NEXN	91624	broad.mit.edu	36	1	78174160	78174160	+	Missense_Mutation	SNP	G	T	T			TCGA-76-4934-01	TCGA-76-4934-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr1:78174160G>T	uc001dic.2	+	c.1316G>T	c.(1315-1317)AGG>ATG	p.R439M	NEXN_uc009wcb.1_Missense_Mutation_p.R361M|NEXN_uc001did.1_Missense_Mutation_p.R349M|NEXN_uc001dif.1_Missense_Mutation_p.R331M|NEXN_uc001dig.2_Missense_Mutation_p.R80M	NM_144573	NP_653174	Q0ZGT2	NEXN_HUMAN	nexilin (F actin binding protein)	439	Glu-rich.				regulation of cell migration|regulation of cytoskeleton organization	cytoskeleton|Z disc	actin filament binding|structural constituent of muscle			ovary(2)	2														0.155172	31.267974	44.451141	18	98	GG		KEEP	---	---	---	---	capture		Colorectal(170;0.114)	Missense_Mutation	SNP	78174160	78174160	10755	1	G	T	T	35	35	NEXN	T	3	3
LPAR3	23566	broad.mit.edu	36	1	85103902	85103902	+	Missense_Mutation	SNP	T	C	C			TCGA-76-4934-01	TCGA-76-4934-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr1:85103902T>C	uc001dkl.2	-	c.490A>G	c.(490-492)ACA>GCA	p.T164A	LPAR3_uc009wcj.1_Missense_Mutation_p.T164A	NM_012152	NP_036284	Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	164	Helical; Name=4; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				ovary(2)	2														0.220109	208.526422	235.151768	81	287	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	85103902	85103902	9279	1	T	C	C	59	59	LPAR3	C	4	4
CD40	958	broad.mit.edu	36	20	44184397	44184397	+	Silent	SNP	C	T	T			TCGA-76-4934-01	TCGA-76-4934-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr20:44184397C>T	uc002xrg.1	+	c.249C>T	c.(247-249)TGC>TGT	p.C83C	CD40_uc002xrf.1_Silent_p.C83C|CD40_uc002xrh.1_Silent_p.C83C|CD40_uc002xri.1_Silent_p.C83C|CD40_uc002xrj.1_Non-coding_Transcript|CD40_uc002xrk.1_Non-coding_Transcript	NM_001250	NP_001241	P25942	TNR5_HUMAN	CD40 antigen isoform 1 precursor	83	TNFR-Cys 2.|Extracellular (Potential).				B cell proliferation|cellular response to mechanical stimulus|inflammatory response|platelet activation|positive regulation of endothelial cell apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein complex assembly	CD40 receptor complex|extracellular region	enzyme binding|receptor activity			skin(1)	1		Myeloproliferative disorder(115;0.0122)			Simvastatin(DB00641)					521				0.25641	97.147729	105.530423	40	116	CC		KEEP	---	---	---	---	capture			Silent	SNP	44184397	44184397	3143	20	C	T	T	27	27	CD40	T	1	1
GLI2	2736	broad.mit.edu	36	2	121442812	121442812	+	Silent	SNP	G	A	A			TCGA-76-4934-01	TCGA-76-4934-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr2:121442812G>A	uc010flp.1	+	c.696G>A	c.(694-696)GCG>GCA	p.A232A	GLI2_uc002tmq.1_Intron|GLI2_uc002tmr.1_Intron|GLI2_uc002tmt.2_Intron|GLI2_uc002tmu.2_Intron|GLI2_uc002tmv.1_Missense_Mutation_p.A103T|GLI2_uc010flo.1_Silent_p.A107A|GLI2_uc002tmw.1_Silent_p.A232A	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	232					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding transcription factor activity|transcription activator activity|zinc ion binding			ovary(7)|central_nervous_system(1)	8	Renal(3;0.0496)	Prostate(154;0.0623)								376				0.519231	315.221724	315.290848	108	100	GG		KEEP	---	---	---	---	capture			Silent	SNP	121442812	121442812	6706	2	G	A	A	38	38	GLI2	A	1	1
GLI2	2736	broad.mit.edu	36	2	121463653	121463653	+	Silent	SNP	C	G	G			TCGA-76-4934-01	TCGA-76-4934-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr2:121463653C>G	uc010flp.1	+	c.3693C>G	c.(3691-3693)GGC>GGG	p.G1231G	GLI2_uc002tmq.1_Intron|GLI2_uc002tmr.1_Intron|GLI2_uc002tmt.2_Silent_p.G903G|GLI2_uc002tmu.2_Silent_p.G886G	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	1231					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding transcription factor activity|transcription activator activity|zinc ion binding			ovary(7)|central_nervous_system(1)	8	Renal(3;0.0496)	Prostate(154;0.0623)								376				0.190476	7.386236	9.269113	4	17	CC		KEEP	---	---	---	---	capture			Silent	SNP	121463653	121463653	6706	2	C	G	G	25	25	GLI2	G	3	3
ZDBF2	57683	broad.mit.edu	36	2	206881267	206881267	+	Missense_Mutation	SNP	C	A	A			TCGA-76-4934-01	TCGA-76-4934-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr2:206881267C>A	uc002vbp.2	+	c.3770C>A	c.(3769-3771)CCT>CAT	p.P1257H		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1257							nucleic acid binding|zinc ion binding			ovary(3)	3														0.321429	45.425469	47.014198	18	38	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	206881267	206881267	18187	2	C	A	A	24	24	ZDBF2	A	3	3
PRKAG3	53632	broad.mit.edu	36	2	219399984	219399984	+	Missense_Mutation	SNP	G	A	A			TCGA-76-4934-01	TCGA-76-4934-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr2:219399984G>A	uc002vjb.1	-	c.1079C>T	c.(1078-1080)GCT>GTT	p.A360V	PRKAG3_uc010fvy.1_Silent_p.L402L	NM_017431	NP_059127	Q9UGI9	AAKG3_HUMAN	AMP-activated protein kinase, non-catalytic	360	CBS 3.				cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|intracellular protein kinase cascade|regulation of fatty acid oxidation	cytosol	AMP-activated protein kinase activity|protein kinase binding			ovary(1)	1		Renal(207;0.0474)												0.275862	189.069707	200.887793	72	189	GG		KEEP	---	---	---	---	capture		Epithelial(149;4.35e-07)|all cancers(144;8.96e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)	Missense_Mutation	SNP	219399984	219399984	12945	2	G	A	A	34	34	PRKAG3	A	2	2
PASK	23178	broad.mit.edu	36	2	241714453	241714453	+	Silent	SNP	C	T	T			TCGA-76-4934-01	TCGA-76-4934-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr2:241714453C>T	uc010fzl.1	-	c.2550G>A	c.(2548-2550)ACG>ACA	p.T850T	PASK_uc002wao.1_Silent_p.T850T|PASK_uc002wap.2_Silent_p.T393T|PASK_uc002waq.2_Silent_p.T850T	NM_015148	NP_055963	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	850				T -> M (in Ref. 2; BAA09484).	protein phosphorylation|regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			ovary(4)|lung(1)|skin(1)	6		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)								754				0.544776	449.861321	450.328497	146	122	CC		KEEP	---	---	---	---	capture		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)	Silent	SNP	241714453	241714453	11889	2	C	T	T	19	19	PASK	T	1	1
STON1-GTF2A1L	286749	broad.mit.edu	36	2	48662607	48662607	+	Missense_Mutation	SNP	G	T	T			TCGA-76-4934-01	TCGA-76-4934-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr2:48662607G>T	uc002rwp.1	+	c.1331G>T	c.(1330-1332)TGC>TTC	p.C444F	STON1_uc002rwo.2_Missense_Mutation_p.C444F|STON1_uc010fbm.1_Missense_Mutation_p.C444F|STON1_uc002rwr.1_Non-coding_Transcript|STON1_uc002rwq.1_Missense_Mutation_p.C444F	NM_172311	NP_758515	B7ZL16	B7ZL16_HUMAN	STON1-GTF2A1L protein	444					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex	RNA polymerase II transcription factor activity			ovary(3)|pancreas(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)												0.527697	575.982799	576.21099	181	162	GG		KEEP	---	---	---	---	capture	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Missense_Mutation	SNP	48662607	48662607	15837	2	G	T	T	46	46	STON1-GTF2A1L	T	3	3
CCDC85A	114800	broad.mit.edu	36	2	56273589	56273589	+	Missense_Mutation	SNP	G	C	C			TCGA-76-4934-01	TCGA-76-4934-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr2:56273589G>C	uc002rzn.1	+	c.750G>C	c.(748-750)AAG>AAC	p.K250N		NM_001080433	NP_001073902	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	250	His-rich.									breast(3)|ovary(2)	5														0.161765	22.88134	30.283588	11	57	GG		KEEP	---	---	---	---	capture	LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)		Missense_Mutation	SNP	56273589	56273589	2983	2	G	C	C	34	34	CCDC85A	C	3	3
C3orf15	89876	broad.mit.edu	36	3	120945684	120945684	+	Missense_Mutation	SNP	G	A	A			TCGA-76-4934-01	TCGA-76-4934-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr3:120945684G>A	uc003ede.2	+	c.1853G>A	c.(1852-1854)CGC>CAC	p.R618H	C3orf15_uc010hqz.1_Missense_Mutation_p.R556H	NM_033364	NP_203528	Q7Z4T9	AAT1_HUMAN	AAT1-alpha	454						mitochondrion	protein binding			ovary(2)|pancreas(1)	3														0.537975	246.579342	246.77799	85	73	GG		KEEP	---	---	---	---	capture		GBM - Glioblastoma multiforme(114;0.186)	Missense_Mutation	SNP	120945684	120945684	2301	3	G	A	A	38	38	C3orf15	A	1	1
FAM194A	131831	broad.mit.edu	36	3	151869895	151869895	+	Silent	SNP	C	T	T			TCGA-76-4934-01	TCGA-76-4934-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr3:151869895C>T	uc003eyg.1	-	c.1377G>A	c.(1375-1377)GTG>GTA	p.V459V	FAM194A_uc003eyh.1_Silent_p.V313V	NM_152394	NP_689607	Q7L0X2	F194A_HUMAN	hypothetical protein LOC131831	459										ovary(1)|skin(1)	2														0.417197	363.737249	365.623745	131	183	CC		KEEP	---	---	---	---	capture			Silent	SNP	151869895	151869895	5737	3	C	T	T	25	25	FAM194A	T	2	2
CNTN4	152330	broad.mit.edu	36	3	3070493	3070493	+	Silent	SNP	C	G	G			TCGA-76-4934-01	TCGA-76-4934-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr3:3070493C>G	uc003bpc.1	+	c.2814C>G	c.(2812-2814)GTC>GTG	p.V938V	CNTN4_uc003bpe.1_Silent_p.V610V|CNTN4_uc003bpf.1_Silent_p.V609V|CNTN4_uc003bpg.1_Silent_p.V194V	NM_175607	NP_783302	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	938	Fibronectin type-III 4.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)												0.126761	6.881818	16.644961	9	62	CC		KEEP	---	---	---	---	capture		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)	Silent	SNP	3070493	3070493	3781	3	C	G	G	32	32	CNTN4	G	3	3
GUCY1A3	2982	broad.mit.edu	36	4	156854003	156854003	+	Nonsense_Mutation	SNP	C	T	T			TCGA-76-4934-01	TCGA-76-4934-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr4:156854003C>T	uc003iov.1	+	c.1390C>T	c.(1390-1392)CAG>TAG	p.Q464*	GUCY1A3_uc010iqc.1_Nonsense_Mutation_p.Q464*|GUCY1A3_uc010iqd.1_Nonsense_Mutation_p.Q463*|GUCY1A3_uc003iow.1_Nonsense_Mutation_p.Q464*|GUCY1A3_uc003iox.1_Nonsense_Mutation_p.Q464*|GUCY1A3_uc003ioy.1_Nonsense_Mutation_p.Q464*|GUCY1A3_uc010iqe.1_Nonsense_Mutation_p.Q229*|GUCY1A3_uc003ioz.1_Nonsense_Mutation_p.Q229*|GUCY1A3_uc003ipa.1_Intron|GUCY1A3_uc003ipb.1_Nonsense_Mutation_p.Q464*	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	464					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)	3	all_hematologic(180;0.24)	Renal(120;0.0854)												0.471545	167.630053	167.717454	58	65	CC		KEEP	---	---	---	---	capture		COAD - Colon adenocarcinoma(41;0.17)	Nonsense_Mutation	SNP	156854003	156854003	7174	4	C	T	T	29	29	GUCY1A3	T	5	2
NAF1	92345	broad.mit.edu	36	4	164269570	164269570	+	Missense_Mutation	SNP	G	A	A			TCGA-76-4934-01	TCGA-76-4934-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr4:164269570G>A	uc003iqj.1	-	c.1414C>T	c.(1414-1416)CCT>TCT	p.P472S	NAF1_uc010iqw.1_Intron	NM_138386	NP_612395	Q96HR8	NAF1_HUMAN	nuclear assembly factor 1 homolog isoform a	472	Pro-rich.				rRNA processing	box H/ACA snoRNP complex|cytoplasm	protein binding|pseudouridine synthase activity|snoRNA binding			ovary(2)	2	all_hematologic(180;0.166)	Prostate(90;0.109)												0.483871	48.423403	48.430444	15	16	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	164269570	164269570	10536	4	G	A	A	43	43	NAF1	A	2	2
KIT	3815	broad.mit.edu	36	4	55256499	55256499	+	Silent	SNP	A	G	G			TCGA-76-4934-01	TCGA-76-4934-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr4:55256499A>G	uc010igr.1	+	c.132A>G	c.(130-132)TCA>TCG	p.S44S	KIT_uc010igs.1_Silent_p.S44S	NM_000222	NP_000213	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral	44	Extracellular (Potential).|Ig-like C2-type 1.				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity			soft_tissue(3041)|haematopoietic_and_lymphoid_tissue(1544)|skin(98)|testis(49)|bone(21)|genital_tract(18)|kidney(17)|ovary(16)|salivary_gland(15)|large_intestine(10)|lung(6)|thymus(5)|central_nervous_system(4)|NS(3)|eye(2)|endometrium(2)|breast(1)|stomach(1)|autonomic_ganglia(1)|pancreas(1)	4855	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)				Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)			1		431				0.974359	3445.368914	3488.594799	950	25	AA		KEEP	---	---	---	---	capture	LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Silent	SNP	55256499	55256499	8641	4	A	G	G	7	7	KIT	G	4	4
ZNF595	152687	broad.mit.edu	36	4	76956	76956	+	Nonsense_Mutation	SNP	C	G	G			TCGA-76-4934-01	TCGA-76-4934-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr4:76956C>G	uc003fzv.1	+	c.1562C>G	c.(1561-1563)TCA>TGA	p.S521*	ZNF595_uc003fzu.1_Intron|ZNF718_uc003fzt.2_Intron	NM_182524	NP_872330	Q7Z3I0	Q7Z3I0_HUMAN	zinc finger protein 595	521					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)												0.244048	127.989994	138.018548	41	127	CC		KEEP	---	---	---	---	capture		Lung(54;0.0654)|Epithelial(2;0.0921)|all cancers(2;0.146)|LUSC - Lung squamous cell carcinoma(95;0.173)	Nonsense_Mutation	SNP	76956	76956	18620	4	C	G	G	29	29	ZNF595	G	5	3
DTWD2	285605	broad.mit.edu	36	5	118352098	118352098	+	Nonsense_Mutation	SNP	G	T	T			TCGA-76-4934-01	TCGA-76-4934-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr5:118352098G>T	uc003ksa.1	-	c.8C>A	c.(7-9)TCG>TAG	p.S3*		NM_173666	NP_775937	Q8NBA8	DTWD2_HUMAN	DTW domain containing 2	3											0		all_epithelial(76;0.0982)|Prostate(80;0.121)										OREG0016736	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0.25641	21.843852	23.935479	10	29	GG		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(64;0.000228)|Epithelial(69;0.000941)|all cancers(49;0.00939)	Nonsense_Mutation	SNP	118352098	118352098	4977	5	G	T	T	37	37	DTWD2	T	5	3
PCDHA5	56143	broad.mit.edu	36	5	140183152	140183152	+	Silent	SNP	G	A	A			TCGA-76-4934-01	TCGA-76-4934-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr5:140183152G>A	uc003lhl.1	+	c.1608G>A	c.(1606-1608)GCG>GCA	p.A536A	PCDHA1_uc003lha.1_Intron|PCDHA1_uc003lhb.1_Intron|PCDHA2_uc003lhd.1_Intron|PCDHA3_uc003lhf.1_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA4_uc003lhi.1_Intron|PCDHA5_uc003lhk.1_Silent_p.A536A|PCDHA5_uc003lhj.1_Silent_p.A536A	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	536	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)	2														0.371257	162.712017	165.140433	62	105	GG		KEEP	---	---	---	---	capture	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Silent	SNP	140183152	140183152	11947	5	G	A	A	38	38	PCDHA5	A	1	1
SLC6A3	6531	broad.mit.edu	36	5	1475074	1475074	+	Missense_Mutation	SNP	G	A	A			TCGA-76-4934-01	TCGA-76-4934-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr5:1475074G>A	uc003jck.2	-	c.709C>T	c.(709-711)CGG>TGG	p.R237W		NM_001044	NP_001035	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter	237	Extracellular (Potential).				cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				ovary(3)|breast(2)|pancreas(1)	6					Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)									0.393204	218.150556	220.198562	81	125	GG		KEEP	---	---	---	---	capture	OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Missense_Mutation	SNP	1475074	1475074	15182	5	G	A	A	38	38	SLC6A3	A	1	1
KIF4B	285643	broad.mit.edu	36	5	154373759	154373759	+	Missense_Mutation	SNP	C	G	G			TCGA-76-4934-01	TCGA-76-4934-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr5:154373759C>G	uc010jih.1	+	c.147C>G	c.(145-147)TTC>TTG	p.F49L		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	49	Kinesin-motor.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)												0.316129	162.01186	166.676661	49	106	CC		KEEP	---	---	---	---	capture	KIRC - Kidney renal clear cell carcinoma(527;0.00112)		Missense_Mutation	SNP	154373759	154373759	8615	5	C	G	G	29	29	KIF4B	G	3	3
STK10	6793	broad.mit.edu	36	5	171442691	171442691	+	Missense_Mutation	SNP	C	T	T			TCGA-76-4934-01	TCGA-76-4934-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr5:171442691C>T	uc003mbo.1	-	c.1688G>A	c.(1687-1689)CGC>CAC	p.R563H		NM_005990	NP_005981	O94804	STK10_HUMAN	serine/threonine kinase 10	563					protein phosphorylation		ATP binding|protein serine/threonine kinase activity			ovary(3)|testis(1)|lung(1)|pancreas(1)	6	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)								570				0.72	290.797663	296.23871	90	35	CC		KEEP	---	---	---	---	capture	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)		Missense_Mutation	SNP	171442691	171442691	15806	5	C	T	T	27	27	STK10	T	1	1
LYSMD3	116068	broad.mit.edu	36	5	89850931	89850931	+	Missense_Mutation	SNP	G	C	C			TCGA-76-4934-01	TCGA-76-4934-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr5:89850931G>C	uc003kjr.1	-	c.382C>G	c.(382-384)CAG>GAG	p.Q128E	LYSMD3_uc010jaz.1_Intron|LYSMD3_uc003kjs.1_Missense_Mutation_p.T108R	NM_198273	NP_938014	Q7Z3D4	LYSM3_HUMAN	LysM, putative peptidoglycan-binding, domain	128	Extracellular (Potential).				cell wall macromolecule catabolic process	integral to membrane					0		all_cancers(142;5.03e-09)|all_epithelial(76;1.23e-11)|Lung NSC(167;2.46e-05)|all_lung(232;3.25e-05)|Ovarian(174;0.00832)|Colorectal(57;0.122)|Breast(839;0.198)												0.440678	376.074859	376.798013	104	132	GG		KEEP	---	---	---	---	capture		OV - Ovarian serous cystadenocarcinoma(54;1.94e-31)|Epithelial(54;5.22e-26)|all cancers(79;2.42e-22)	Missense_Mutation	SNP	89850931	89850931	9503	5	G	C	C	48	48	LYSMD3	C	3	3
UNC5CL	222643	broad.mit.edu	36	6	41108805	41108805	+	Silent	SNP	G	A	A			TCGA-76-4934-01	TCGA-76-4934-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr6:41108805G>A	uc003opi.1	-	c.745C>T	c.(745-747)CTG>TTG	p.L249L		NM_173561	NP_775832	Q8IV45	UN5CL_HUMAN	unc-5 homolog C-like	249	Cytoplasmic (Potential).|Interaction with RELA and NFKB1.				signal transduction	cytoplasm|integral to membrane				ovary(2)	2	Ovarian(28;0.0418)|Colorectal(47;0.196)													0.173913	7.020816	9.302318	4	19	GG		KEEP	---	---	---	---	capture			Silent	SNP	41108805	41108805	17552	6	G	A	A	34	34	UNC5CL	A	2	2
TJAP1	93643	broad.mit.edu	36	6	43580939	43580939	+	Missense_Mutation	SNP	C	T	T			TCGA-76-4934-01	TCGA-76-4934-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr6:43580939C>T	uc003ovd.1	+	c.1042C>T	c.(1042-1044)CCC>TCC	p.P348S	TJAP1_uc003ovc.1_Missense_Mutation_p.P338S|TJAP1_uc010jyp.1_Missense_Mutation_p.P307S|TJAP1_uc003ove.1_Missense_Mutation_p.P338S|TJAP1_uc003ovf.1_Missense_Mutation_p.P338S|TJAP1_uc003ovg.1_Missense_Mutation_p.P214S|TJAP1_uc003ovh.1_Missense_Mutation_p.P165S|TJAP1_uc003ovi.1_Missense_Mutation_p.P214S	NM_080604	NP_542171	Q5JTD0	TJAP1_HUMAN	tight junction protein 4 (peripheral)	348						Golgi apparatus|tight junction	protein binding				0	all_lung(25;0.00536)													0.344444	160.363423	164.224677	62	118	CC		KEEP	---	---	---	---	capture	Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0122)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)		Missense_Mutation	SNP	43580939	43580939	16457	6	C	T	T	26	26	TJAP1	T	2	2
GPR116	221395	broad.mit.edu	36	6	46934914	46934914	+	Silent	SNP	C	T	T			TCGA-76-4934-01	TCGA-76-4934-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr6:46934914C>T	uc003oyo.2	-	c.2685G>A	c.(2683-2685)TCG>TCA	p.S895S	GPR116_uc003oyp.2_Silent_p.S753S|GPR116_uc003oyq.2_Silent_p.S895S|GPR116_uc010jzi.1_Silent_p.S567S	NM_001098518	NP_056049	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116	895	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)	1						NSCLC(59;410 1274 8751 36715 50546)								0.481675	274.28529	274.341017	92	99	CC		KEEP	---	---	---	---	capture	Lung(136;0.192)		Silent	SNP	46934914	46934914	6907	6	C	T	T	19	19	GPR116	T	1	1
CAGE1	285782	broad.mit.edu	36	6	7315287	7315287	+	Missense_Mutation	SNP	G	A	A			TCGA-76-4934-01	TCGA-76-4934-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr6:7315287G>A	uc003mxi.1	-	c.1349C>T	c.(1348-1350)ACG>ATG	p.T450M	CAGE1_uc003mxh.1_Non-coding_Transcript|CAGE1_uc003mxj.1_Missense_Mutation_p.T341M|CAGE1_uc003mxk.1_Missense_Mutation_p.T341M	NM_205864	NP_995586	Q8TC20	CAGE1_HUMAN	cancer antigen 1	586											0	Ovarian(93;0.0418)													0.393258	100.70349	101.591872	35	54	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	7315287	7315287	2688	6	G	A	A	40	40	CAGE1	A	1	1
FEZF1	389549	broad.mit.edu	36	7	121730546	121730546	+	Missense_Mutation	SNP	C	T	T			TCGA-76-4934-01	TCGA-76-4934-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr7:121730546C>T	uc003vkd.1	-	c.857G>A	c.(856-858)AGA>AAA	p.R286K	FEZF1_uc003vkc.1_Missense_Mutation_p.R236K|FEZF1_uc003vke.1_Missense_Mutation_p.R282K	NM_001024613	NP_001019784	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1	286					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)	3														0.411765	265.962341	267.349963	84	120	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	121730546	121730546	6062	7	C	T	T	32	32	FEZF1	T	2	2
POM121C	100101267	broad.mit.edu	36	7	74886058	74886058	+	Missense_Mutation	SNP	C	A	A			TCGA-76-4934-01	TCGA-76-4934-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr7:74886058C>A	uc003udk.2	-	c.2921G>T	c.(2920-2922)CGA>CTA	p.R974L		NM_001099415	NP_001092885	A8CG34	P121C_HUMAN	POM121 membrane glycoprotein (rat)-like	1216	Pore side (Potential).				mRNA transport|protein transport|transmembrane transport	endoplasmic reticulum membrane|nuclear membrane|nuclear pore	protein binding				0														0.555556	109.127796	109.296723	35	28	CC		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	74886058	74886058	12668	7	C	A	A	31	31	POM121C	A	3	3
COL1A2	1278	broad.mit.edu	36	7	93878335	93878335	+	Missense_Mutation	SNP	C	T	T			TCGA-76-4934-01	TCGA-76-4934-01	C	C								Phase_I	Unspecified				Illumina GAIIx	g.chr7:93878335C>T	uc003ung.1	+	c.1283C>T	c.(1282-1284)CCT>CTT	p.P428L		NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen	428					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging			central_nervous_system(3)|ovary(2)	5	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)				Collagenase(DB00048)									0.194444	17.103146	20.238795	7	29	CC		KEEP	---	---	---	---	capture	STAD - Stomach adenocarcinoma(171;0.0031)		Missense_Mutation	SNP	93878335	93878335	3816	7	C	T	T	24	24	COL1A2	T	2	2
FGL1	2267	broad.mit.edu	36	8	17770516	17770516	+	Silent	SNP	G	A	A			TCGA-76-4934-01	TCGA-76-4934-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chr8:17770516G>A	uc003wye.1	-	c.750C>T	c.(748-750)TAC>TAT	p.Y250Y	FGL1_uc003wxx.1_Silent_p.Y200Y|FGL1_uc003wxy.1_Silent_p.Y200Y|FGL1_uc003wxz.1_Silent_p.Y199Y|FGL1_uc003wya.1_Silent_p.Y200Y|FGL1_uc003wyb.1_Silent_p.Y200Y|FGL1_uc003wyc.1_Silent_p.Y200Y|FGL1_uc003wyd.1_Non-coding_Transcript|FGL1_uc003wyf.1_Silent_p.Y170Y	NM_201553	NP_963847	Q08830	FGL1_HUMAN	fibrinogen-like 1 precursor	200	Fibrinogen C-terminal.				signal transduction	fibrinogen complex	receptor binding				0														0.25	69.242488	75.608084	28	84	GG		KEEP	---	---	---	---	capture		Colorectal(111;0.0573)|COAD - Colon adenocarcinoma(73;0.215)	Silent	SNP	17770516	17770516	6109	8	G	A	A	40	40	FGL1	A	1	1
CLDN23	137075	broad.mit.edu	36	8	8597431	8597431	+	Missense_Mutation	SNP	A	C	C			TCGA-76-4934-01	TCGA-76-4934-01	A	A								Phase_I	Unspecified				Illumina GAIIx	g.chr8:8597431A>C	uc003wsi.1	+	c.113A>C	c.(112-114)AAC>ACC	p.N38T		NM_194284	NP_919260	Q96B33	CLD23_HUMAN	claudin 23	38	Extracellular (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity				0		Hepatocellular(245;0.217)												0.5	10.597767	10.597767	4	4	AA		KEEP	---	---	---	---	capture		COAD - Colon adenocarcinoma(149;0.071)|READ - Rectum adenocarcinoma(644;0.238)	Missense_Mutation	SNP	8597431	8597431	3620	8	A	C	C	2	2	CLDN23	C	4	4
DCAF4L2	138009	broad.mit.edu	36	8	88955162	88955162	+	Missense_Mutation	SNP	T	A	A			TCGA-76-4934-01	TCGA-76-4934-01	T	T								Phase_I	Unspecified				Illumina GAIIx	g.chr8:88955162T>A	uc003ydz.1	-	c.154A>T	c.(154-156)AGC>TGC	p.S52C		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	52										ovary(1)	1														0.596591	316.180624	317.611332	105	71	TT		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	88955162	88955162	4443	8	T	A	A	56	56	DCAF4L2	A	4	4
CXorf57	55086	broad.mit.edu	36	X	105742219	105742219	+	Missense_Mutation	SNP	G	A	A			TCGA-76-4934-01	TCGA-76-4934-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chrX:105742219G>A	uc004emi.2	+	c.253G>A	c.(253-255)GAC>AAC	p.D85N	CXorf57_uc004emj.2_Missense_Mutation_p.D85N|CXorf57_uc004emh.2_Missense_Mutation_p.D85N	NM_018015	NP_060485	Q6NSI4	CX057_HUMAN	hypothetical protein LOC55086	85										ovary(1)|lung(1)|breast(1)	3														0.250765	196.204102	214.660997	82	245	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	105742219	105742219	4277	23	G	A	A	37	37	CXorf57	A	1	1
ZNF280C	55609	broad.mit.edu	36	X	129182069	129182069	+	Missense_Mutation	SNP	G	A	A			TCGA-76-4934-01	TCGA-76-4934-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chrX:129182069G>A	uc004evm.1	-	c.1462C>T	c.(1462-1464)CAT>TAT	p.H488Y	ZNF280C_uc010nrf.1_Missense_Mutation_p.H439Y	NM_017666	NP_060136	Q8ND82	Z280C_HUMAN	zinc finger protein 280C	488	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)	3														0.435821	421.185638	422.391181	146	189	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	129182069	129182069	18408	23	G	A	A	48	48	ZNF280C	A	2	2
ARSE	415	broad.mit.edu	36	X	2877360	2877360	+	Missense_Mutation	SNP	G	A	A			TCGA-76-4934-01	TCGA-76-4934-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chrX:2877360G>A	uc004crc.2	-	c.839C>T	c.(838-840)GCG>GTG	p.A280V		NM_000047	NP_000038	P51690	ARSE_HUMAN	arylsulfatase E precursor	280					skeletal system development	Golgi stack	arylsulfatase activity|metal ion binding			ovary(1)|central_nervous_system(1)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)												0.207547	74.188102	86.786405	33	126	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	2877360	2877360	1008	23	G	A	A	38	38	ARSE	A	1	1
STARD8	9754	broad.mit.edu	36	X	67854056	67854056	+	Missense_Mutation	SNP	G	A	A			TCGA-76-4934-01	TCGA-76-4934-01	G	G								Phase_I	Unspecified				Illumina GAIIx	g.chrX:67854056G>A	uc004dxb.1	+	c.575G>A	c.(574-576)GGC>GAC	p.G192D	STARD8_uc004dxa.1_Missense_Mutation_p.G112D|STARD8_uc004dxc.2_Missense_Mutation_p.G112D	NM_014725	NP_055540	Q92502	STAR8_HUMAN	StAR-related lipid transfer (START) domain	112					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion	GTPase activator activity			breast(3)|ovary(2)|pancreas(1)	6														0.508621	176.94725	176.955629	59	57	GG		KEEP	---	---	---	---	capture			Missense_Mutation	SNP	67854056	67854056	15782	23	G	A	A	42	42	STARD8	A	2	2
GPATCH1	55094	broad.mit.edu	36	19	38270953	38270953	+	Frame_Shift_Del	DEL	C	-	-			TCGA-76-4934-01	TCGA-76-4934-01										Phase_I	Unspecified				Illumina GAIIx	g.chr19:38270953_38270953delC	uc002nug.1	+	c.147_147delC	c.(145-147)TTCfs	p.F49fs		NM_018025	NP_060495	Q9BRR8	GPTC1_HUMAN	G patch domain containing 1	49					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome	nucleic acid binding				0	Esophageal squamous(110;0.137)					Pancreas(67;88 1713 4567 18227)								0.44			81	105				---	---	---	---	capture_indel			Frame_Shift_Del	DEL	38270953	38270953	6864	19	C	-	-	30	30	GPATCH1	-	5	5
PTPN18	26469	broad.mit.edu	36	2	130846399	130846404	+	In_Frame_Del	DEL	GACGGG	-	-			TCGA-76-4934-01	TCGA-76-4934-01										Phase_I	Unspecified				Illumina GAIIx	g.chr2:130846399_130846404delGACGGG	uc002trc.1	+	c.1113_1118delGACGGG	c.(1111-1119)CAGACGGGG>CAG	p.TG378del	PTPN18_uc002trb.1_In_Frame_Del_p.TG271del|PTPN18_uc002trd.1_In_Frame_Del_p.TG357del|PTPN18_uc002tre.1_In_Frame_Del_p.TG29del	NM_014369	NP_055184	Q99952	PTN18_HUMAN	protein tyrosine phosphatase, non-receptor type	378_379				Missing (in Ref. 1; CAA56105).		cytoplasm|nucleus	non-membrane spanning protein tyrosine phosphatase activity			ovary(3)|kidney(1)	4	Colorectal(110;0.1)													0.33			3	6				---	---	---	---	capture_indel			In_Frame_Del	DEL	130846399	130846404	13239	2	GACGGG	-	-	33	33	PTPN18	-	5	5
C9orf150	286343	broad.mit.edu	36	9	12765861	12765862	+	In_Frame_Ins	INS	-	GGCGGCGGC	GGCGGCGGC			TCGA-76-4934-01	TCGA-76-4934-01										Phase_I	Unspecified				Illumina GAIIx	g.chr9:12765861_12765862insGGCGGCGGC	uc003zkw.1	+	c.147_148insGGCGGCGGC	c.(145-150)insGGCGGCGGC	p.55_56insGGG		NM_203403	NP_981948	Q8IV03	CI150_HUMAN	hypothetical protein LOC286343	58_59	Gly-rich.										0				GBM - Glioblastoma multiforme(1;1.64e-13)										0.33			4	8				---	---	---	---	capture_indel			In_Frame_Ins	INS	12765861	12765862	2576	9	-	GGCGGCGGC	GGCGGCGGC	59	59	C9orf150	GGCGGCGGC	5	5
