Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CROCCL1	84809	broad.mit.edu	37	1	16946434	16946434	+	RNA	SNP	C	T	T	rs367060		TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr1:16946434C>T	uc010ocf.1	-	3		c.464G>A			CROCCL1_uc009vov.1_RNA|CROCCL1_uc001aze.2_RNA|CROCCL1_uc001azf.2_RNA					Homo sapiens mRNA for FLJ00313 protein.												0						CTCAGCCTTCCGCCGGGCCAG	0.672													7	30	---	---	---	---	0	0	0.038147	0	0
CROCCL1	84809	broad.mit.edu	37	1	16946438	16946438	+	RNA	SNP	G	A	A	rs28392876	by1000genomes	TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr1:16946438G>A	uc010ocf.1	-	3		c.460C>T			CROCCL1_uc009vov.1_RNA|CROCCL1_uc001aze.2_RNA|CROCCL1_uc001azf.2_RNA					Homo sapiens mRNA for FLJ00313 protein.												0						GCCTTCCGCCGGGCCAGCAGC	0.672													7	30	---	---	---	---	0	0	0.038147	0	0
UBR4	23352	broad.mit.edu	37	1	19420477	19420477	+	Missense_Mutation	SNP	C	A	A			TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr1:19420477C>A	uc001bbi.2	-	95	13907	c.13903G>T	c.(13903-13905)GTG>TTG	p.V4635L	UBR4_uc010ocv.1_Missense_Mutation_p.V158L|UBR4_uc009vph.2_Missense_Mutation_p.V269L|UBR4_uc010ocw.1_Missense_Mutation_p.V299L|UBR4_uc001bbg.2_Missense_Mutation_p.V346L|UBR4_uc001bbh.2_Missense_Mutation_p.V344L	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	4635					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		AATCGCTCCACCAAGATCTGC	0.463													17	26	---	---	---	---	4.75885e-15	5.36896e-15	0.033300	1	0
NLRP3	114548	broad.mit.edu	37	1	247586597	247586597	+	Missense_Mutation	SNP	T	C	C			TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr1:247586597T>C	uc001icr.2	+	4	487	c.349T>C	c.(349-351)TGG>CGG	p.W117R	NLRP3_uc001ics.2_Missense_Mutation_p.W117R|NLRP3_uc001icu.2_Missense_Mutation_p.W117R|NLRP3_uc001icw.2_Missense_Mutation_p.W117R|NLRP3_uc001icv.2_Missense_Mutation_p.W117R|NLRP3_uc010pyw.1_Missense_Mutation_p.W115R|NLRP3_uc001ict.1_Missense_Mutation_p.W115R	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	117					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding	p.W117L(1)		lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			TGAAGAGGAGTGGATGGGTTT	0.423													94	108	---	---	---	---	0	0	0.048971	0	0
HRAS	3265	broad.mit.edu	37	11	533874	533874	+	Missense_Mutation	SNP	T	C	C	rs121913233		TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr11:533874T>C	uc001lpv.2	-	3	370	c.182A>G	c.(181-183)CAG>CGG	p.Q61R	HRAS_uc010qvw.1_Missense_Mutation_p.Q61R|HRAS_uc010qvx.1_Missense_Mutation_p.Q61R|HRAS_uc010qvy.1_RNA	NM_005343	NP_005334	P01112	RASH_HUMAN	v-Ha-ras Harvey rat sarcoma viral oncogene	61	GTP.		Q -> L (in melanoma; strongly reduced GTP hydrolysis in the presence of RAF1; increases transformation of cultured cell lines).	Q->V: Strongly increased transformation of cultured cell lines.|Q->I: Moderately increased transformation of cultured cell lines.	activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.Q61R(112)|p.Q61L(93)|p.Q61K(39)|p.Q61H(20)|p.Q61P(3)|p.Q61Q(1)|p.Q61E(1)		urinary_tract(174)|thyroid(155)|skin(126)|upper_aerodigestive_tract(112)|soft_tissue(37)|prostate(29)|salivary_gland(24)|cervix(23)|stomach(14)|pituitary(10)|lung(9)|haematopoietic_and_lymphoid_tissue(9)|breast(6)|testis(5)|endometrium(4)|bone(3)|large_intestine(2)|oesophagus(2)|penis(2)|kidney(1)|adrenal_gland(1)|thymus(1)	749		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	GTACTCCTCCTGGCCGGCGGT	0.597	Q61L(KNS62_LUNG)|Q61L(NCIH1915_LUNG)|Q61L(KYSE30_OESOPHAGUS)	6	Mis		infrequent sarcomas|rare other types	rhadomyosarcoma|ganglioneuroblastoma|bladder			Costello_syndrome	HNSCC(11;0.0054)			61	100	---	---	---	---	0	0	0.048971	0	0
MUC5B	727897	broad.mit.edu	37	11	1275535	1275535	+	Missense_Mutation	SNP	A	T	T			TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr11:1275535A>T	uc009ycr.1	+	56	16568	c.16442A>T	c.(16441-16443)GAT>GTT	p.D5481V	MUC5B_uc001ltb.2_Missense_Mutation_p.D5147V	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	5144	VWFD 4.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		AAGTCCATGGATATCGTCCTC	0.642													23	32	---	---	---	---	0	0	0.108266	0	0
PIK3C2A	5286	broad.mit.edu	37	11	17144297	17144297	+	Silent	SNP	A	G	G			TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr11:17144297A>G	uc001mmq.3	-	13	2529	c.2463T>C	c.(2461-2463)CCT>CCC	p.P821P	PIK3C2A_uc009ygu.1_Intron|PIK3C2A_uc010rcw.1_Silent_p.P441P|PIK3C2A_uc001mmr.3_Intron	NM_002645	NP_002636	O00443	P3C2A_HUMAN	phosphoinositide-3-kinase, class 2 alpha	821					cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(4)|central_nervous_system(4)|stomach(1)|ovary(1)	10					Phosphatidylserine(DB00144)	TAACTGTTCCAGGAACAGAAT	0.313													7	75	---	---	---	---	0	0	0.029380	0	0
PDE3A	5139	broad.mit.edu	37	12	20799741	20799741	+	Missense_Mutation	SNP	A	T	T			TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr12:20799741A>T	uc001reh.1	+	12	2444	c.2422A>T	c.(2422-2424)AAT>TAT	p.N808Y		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	808	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	AAAAACGTATAATGTGACAGA	0.398													98	109	---	---	---	---	0	0	0.048971	0	0
LOC284232	284232	broad.mit.edu	37	13	19411886	19411886	+	RNA	SNP	A	C	C			TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr13:19411886A>C	uc010tcj.1	-	1		c.34224T>G				NR_027995				Homo sapiens ankyrin repeat domain 20 family, member A2 pseudogene (LOC284232), non-coding RNA.												0						tgtagcaagcagagatcccac	0.129													4	36	---	---	---	---	0	0	0.029380	0	0
PRKD1	5587	broad.mit.edu	37	14	30066788	30066788	+	Missense_Mutation	SNP	G	C	C			TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr14:30066788G>C	uc001wqh.2	-	16	2524	c.2343C>G	c.(2341-2343)TTC>TTG	p.F781L		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	781	Protein kinase.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		CATTAAATGGGAATGTGCCGC	0.438													75	79	---	---	---	---	0	0	0.048971	0	0
ZNF652	22834	broad.mit.edu	37	17	47375973	47375973	+	Silent	SNP	C	A	A			TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr17:47375973C>A	uc002iov.3	-	6	2087	c.1623G>T	c.(1621-1623)CGG>CGT	p.R541R	ZNF652_uc002iow.2_Silent_p.R541R|ZNF652_uc002iou.3_RNA	NM_001145365	NP_001138837	Q9Y2D9	ZN652_HUMAN	zinc finger protein 652	541	Mediates interaction with CBFA2T3.|Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1	all_cancers(4;6.81e-14)|Breast(4;4.97e-29)|all_epithelial(4;1.53e-17)		BRCA - Breast invasive adenocarcinoma(1;3.1e-14)|Epithelial(5;2.92e-06)|all cancers(6;3.15e-05)			gggggatgggccgagggGGAA	0.244													22	30	---	---	---	---	1.36565e-18	1.62401e-18	0.076483	1	0
POTEC	388468	broad.mit.edu	37	18	14542921	14542921	+	Silent	SNP	G	A	A			TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr18:14542921G>A	uc010dln.2	-	1	679	c.225C>T	c.(223-225)AGC>AGT	p.S75S	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	75										skin(3)	3						TGCTCGTGCCGCTCCCCCTGC	0.567													113	234	---	---	---	---	0	0	0.048971	0	0
MUC16	94025	broad.mit.edu	37	19	9049457	9049457	+	Missense_Mutation	SNP	G	C	C			TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr19:9049457G>C	uc002mkp.2	-	5	32378	c.32174C>G	c.(32173-32175)CCA>CGA	p.P10725R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10727	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGTCATAATTGGAATAGCTGA	0.443													159	215	---	---	---	---	0	0	0.048971	0	0
SNRNP27	11017	broad.mit.edu	37	2	70121125	70121125	+	Silent	SNP	C	T	T			TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr2:70121125C>T	uc002sfw.2	+	1	36	c.9C>T	c.(7-9)CGC>CGT	p.R3R	SNRNP27_uc002sfv.2_RNA|SNRNP27_uc002sfx.2_Silent_p.R3R	NM_006857	NP_006848	Q8WVK2	SNR27_HUMAN	small nuclear ribonucleoprotein 27kDa	3	Arg-rich.				mRNA processing|RNA splicing	nucleus	nucleic acid binding				0						AAATGGGTCGCAGTCGCAGCC	0.527													35	35	---	---	---	---	0	0	0.086207	0	0
FAM182B	728882	broad.mit.edu	37	20	25848617	25848617	+	RNA	SNP	A	G	G			TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr20:25848617A>G	uc002wvd.1	-	1		c.170T>C								Homo sapiens cDNA FLJ30282 fis, clone BRACE2002803.												0						ggcaggcctgaggctgggatg	0													2	8	---	---	---	---	0	0	0.004672	0	0
LOC96610	96610	broad.mit.edu	37	22	22664186	22664186	+	RNA	SNP	A	G	G			TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr22:22664186A>G	uc011aim.1	+	30		c.2043A>G			LOC96610_uc011aiq.1_RNA					Parts of antibodies, mostly variable regions.												0						CAGATCAAGAAAGCACTCTGA	0.498													4	100	---	---	---	---	0	0	0.009096	0	0
Unknown	0	broad.mit.edu	37	22	32435498	32435498	+	IGR	SNP	C	T	T			TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr22:32435498C>T								YWHAH (81909 upstream) : SLC5A1 (3539 downstream)																							TGCACCAAAACCGTGAAGAAG	0.527													42	8	---	---	---	---	0	0	0.086207	0	0
CACNA2D1	781	broad.mit.edu	37	7	81594935	81594936	+	Missense_Mutation	DNP	GC	TT	TT			TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr7:81594935_81594936GC>TT	uc003uhr.1	-	32	2804_2805	c.2548_2549GC>AA	c.(2548-2550)GCA>AAA	p.A850K	CACNA2D1_uc011kgy.1_Missense_Mutation_p.A62K	NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	862	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	ATCATGATTTGCCATCAGAAGA	0.366													46	80	---	---	---	---	0	0	0.004672	0	0
IRF5	3663	broad.mit.edu	37	7	128588864	128588864	+	Missense_Mutation	SNP	A	T	T			TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr7:128588864A>T	uc003vog.2	+	10	1628	c.1507A>T	c.(1507-1509)ATG>TTG	p.M503L	IRF5_uc003voh.2_Missense_Mutation_p.M487L|IRF5_uc010llt.2_Missense_Mutation_p.M411L|IRF5_uc003voi.2_Missense_Mutation_p.M487L|IRF5_uc003voj.3_Missense_Mutation_p.M487L	NM_002200	NP_002191	Q13568	IRF5_HUMAN	interferon regulatory factor 5 isoform a	497					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						CCCAGCTGGCATGCAATAACA	0.657													44	46	---	---	---	---	0	0	0.048971	0	0
WEE2	494551	broad.mit.edu	37	7	141420816	141420816	+	Silent	SNP	A	T	T			TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr7:141420816A>T	uc003vwn.2	+	5	1246	c.840A>T	c.(838-840)GCA>GCT	p.A280A	FLJ40852_uc011krh.1_Intron|FLJ40852_uc010lnm.2_Intron|FLJ40852_uc010lnn.2_Intron|FLJ40852_uc003vwm.3_Intron|FLJ40852_uc010lno.2_Intron	NM_001105558	NP_001099028	P0C1S8	WEE2_HUMAN	WEE1 homolog 2	280	Protein kinase.				egg activation|female meiosis|female pronucleus assembly|meiotic metaphase II|meiotic prophase I|mitosis|negative regulation of oocyte development|regulation of meiosis I	centrosome|nucleus	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2	Melanoma(164;0.0171)					CCTCATGGGCAGAAGATGACC	0.413													93	86	---	---	---	---	0	0	0.048971	0	0
PTK2B	2185	broad.mit.edu	37	8	27294958	27294958	+	Missense_Mutation	SNP	G	A	A			TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr8:27294958G>A	uc003xfn.1	+	22	2280	c.1472G>A	c.(1471-1473)GGC>GAC	p.G491D	PTK2B_uc003xfo.1_Missense_Mutation_p.G491D|PTK2B_uc003xfp.1_Missense_Mutation_p.G491D|PTK2B_uc003xfq.1_Missense_Mutation_p.G491D|PTK2B_uc003xfr.1_Missense_Mutation_p.G237D	NM_173174	NP_775266	Q14289	FAK2_HUMAN	PTK2B protein tyrosine kinase 2 beta isoform a	491	Protein kinase.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			lung(3)|ovary(1)|skin(1)	5		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		AAGCTGATCGGCATCATTGAA	0.567													49	66	---	---	---	---	0	0	0.048971	0	0
MIR599	693184	broad.mit.edu	37	8	100548875	100548875	+	RNA	SNP	A	T	T			TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr8:100548875A>T	hsa-mir-599|MI0003611	-			c.84A>T			VPS13B_uc003yiv.2_Intron|VPS13B_uc003yiw.2_Intron																	0						TCATCCAAGTATGGGTTTGAT	0.398													27	32	---	---	---	---	0	0	0.034045	0	0
HRCT1	646962	broad.mit.edu	37	9	35906344	35906344	+	Silent	SNP	G	A	A			TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr9:35906344G>A	uc003zyr.1	+	1	156	c.60G>A	c.(58-60)GCG>GCA	p.A20A		NM_001039792	NP_001034881	Q6UXD1	HRCT1_HUMAN	histidine rich carboxyl terminus 1	20	Helical; (Potential).					integral to membrane					0						CTGCTGTGGCGGTCctgctgc	0.587													3	16	---	---	---	---	0	0	0.004672	0	0
NANS	54187	broad.mit.edu	37	9	100845135	100845135	+	Missense_Mutation	SNP	A	C	C			TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr9:100845135A>C	uc004ayb.2	+	7	1520	c.878A>C	c.(877-879)AAG>ACG	p.K293T	NANS_uc004ayc.2_Missense_Mutation_p.K293T|TRIM14_uc004ayd.2_Intron|TRIM14_uc004ayf.1_Intron	NM_018946	NP_061819	Q9NR45	SIAS_HUMAN	N-acetylneuraminic acid phosphate synthase	293					lipopolysaccharide biosynthetic process	cytoplasm	N-acetylneuraminate synthase activity|N-acylneuraminate cytidylyltransferase activity|N-acylneuraminate-9-phosphate synthase activity			skin(1)	1		Acute lymphoblastic leukemia(62;0.0559)				CAGCTGGGCAAGTCTGTGGTG	0.488													32	37	---	---	---	---	0	0	0.045705	0	0
KIAA2022	340533	broad.mit.edu	37	X	73963336	73963336	+	Missense_Mutation	SNP	A	C	C			TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chrX:73963336A>C	uc004eby.2	-	3	1673	c.1056T>G	c.(1054-1056)AGT>AGG	p.S352R		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	352					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						TCAGGGCCCCACTCTTAGACT	0.468													4	71	---	---	---	---	0	0	0.009096	0	0
Unknown	0	broad.mit.edu	37	1	26282285	26282288	+	IGR	DEL	GAAG	-	-			TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr1:26282285_26282288delGAAG								STMN1 (48917 upstream) : PAFAH2 (3972 downstream)																							ggaaaggaaagaaggaaggaagga	0.113													2	4	---	---	---	---					
TMEM63A	9725	broad.mit.edu	37	1	226034840	226034842	+	In_Frame_Del	DEL	CTG	-	-			TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr1:226034840_226034842delCTG	uc001hpm.1	-	24	2573_2575	c.2323_2325delCAG	c.(2323-2325)CAGdel	p.Q775del		NM_014698	NP_055513	O94886	TM63A_HUMAN	transmembrane protein 63A	775						integral to membrane|lysosomal membrane	nucleotide binding			ovary(1)|breast(1)	2	Breast(184;0.197)					CACCATAGGTCTGCTGCTGCTGC	0.626													9	219	---	---	---	---					
Unknown	0	broad.mit.edu	37	10	11704259	11704260	+	IGR	INS	-	GAAGGAAA	GAAGGAAA	rs113401656		TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr10:11704259_11704260insGAAGGAAA								USP6NL (50580 upstream) : ECHDC3 (80096 downstream)																							aaggaaggaagggaaggaagga	0.000													3	6	---	---	---	---					
Unknown	0	broad.mit.edu	37	10	134206071	134206072	+	IGR	INS	-	TGATGG	TGATGG			TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr10:134206071_134206072insTGATGG								LRRC27 (11061 upstream) : PWWP2B (4630 downstream)																							ggtaatggtgatgatggtgatg	0.000													3	5	---	---	---	---					
Unknown	0	broad.mit.edu	37	11	55189538	55189539	+	IGR	INS	-	TTCC	TTCC	rs7940575	by1000genomes	TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr11:55189538_55189539insTTCC								OR4A15 (53145 upstream) : OR4C15 (132244 downstream)																							tccttccttcgttccttccttc	0.000													2	4	---	---	---	---					
MALAT1	378938	broad.mit.edu	37	11	65269981	65269984	+	RNA	DEL	TTGT	-	-			TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr11:65269981_65269984delTTGT	uc010roh.1	+	1		c.4749_4752delTTGT			uc001ody.2_RNA|MALAT1_uc001odz.2_Intron	NR_002819				Homo sapiens clone alpha1 mRNA sequence.												0						ATTTTGTAAATTGTTTATTTTAAA	0.309													13	23	---	---	---	---					
SUOX	6821	broad.mit.edu	37	12	56397583	56397583	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr12:56397583delG	uc001six.2	+	6	736	c.410delG	c.(409-411)TGGfs	p.W137fs	SUOX_uc001siy.2_Frame_Shift_Del_p.W137fs|SUOX_uc001siz.2_Frame_Shift_Del_p.W137fs|SUOX_uc001sja.2_Frame_Shift_Del_p.W137fs	NM_000456	NP_000447	P51687	SUOX_HUMAN	sulfite oxidase precursor	137	Cytochrome b5 heme-binding.					mitochondrial intermembrane space	electron carrier activity|molybdenum ion binding|sulfite oxidase activity				0			UCEC - Uterine corpus endometrioid carcinoma (6;0.0471)|OV - Ovarian serous cystadenocarcinoma(18;0.119)			GAGCCCTTCTGGGCCCTCTAT	0.557													97	126	---	---	---	---					
Unknown	0	broad.mit.edu	37	12	72473185	72473185	+	IGR	DEL	T	-	-			TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr12:72473185delT								TPH2 (46964 upstream) : LOC283392 (183143 downstream)																							ccttccttccttccttccttc	0.164													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	13	111293683	111293684	+	IGR	INS	-	ATCG	ATCG	rs138202676	by1000genomes	TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr13:111293683_111293684insATCG								CARKD (1343 upstream) : CARS2 (73 downstream)																							TACTTCACTCAATCGACGGTGA	0.525													6	3	---	---	---	---					
HAGHL	84264	broad.mit.edu	37	16	778954	778955	+	Frame_Shift_Ins	INS	-	G	G			TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr16:778954_778955insG	uc002cjl.1	+	7	940_941	c.659_660insG	c.(658-660)GTGfs	p.V220fs	CCDC78_uc002cji.3_5'Flank|CCDC78_uc002cjg.2_5'Flank|CCDC78_uc002cjj.3_5'Flank|CCDC78_uc002cjh.2_5'Flank|CCDC78_uc010uuo.1_5'Flank|CCDC78_uc002cjk.2_5'Flank|HAGHL_uc002cjm.1_3'UTR|HAGHL_uc002cjn.1_3'UTR|HAGHL_uc002cjo.1_Intron|HAGHL_uc010uup.1_Intron	NM_207112	NP_996995	Q6PII5	HAGHL_HUMAN	hydroxyacylglutathione hydrolase-like isoform 1	220							hydrolase activity|metal ion binding				0		Hepatocellular(780;0.00335)				GGCTTCGGGGTGGGGGGGGCTC	0.668													3	4	---	---	---	---					
POLDIP2	26073	broad.mit.edu	37	17	26684394	26684395	+	Splice_Site	INS	-	G	G	rs113730440		TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr17:26684394_26684395insG	uc002haz.2	-	2	210	c.78_splice	c.e2+1	p.W26_splice	POLDIP2_uc010wag.1_RNA|TMEM199_uc002hba.2_5'Flank|SARM1_uc010wah.1_5'Flank	NM_015584	NP_056399	Q9Y2S7	PDIP2_HUMAN	DNA polymerase delta interacting protein 2							mitochondrial nucleoid|nucleus					0	all_lung(13;0.000354)|Lung NSC(42;0.00115)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		AGAGCGGCTTTGCCACCGGGCC	0.762													3	5	---	---	---	---					
Unknown	0	broad.mit.edu	37	22	25627870	25627871	+	IGR	INS	-	GTGT	GTGT	rs71834242		TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr22:25627870_25627871insGTGT								CRYBB2 (34 upstream) : IGLL3 (86017 downstream)																							CCTGGCAGCTGgtgtgtgtgtg	0.351													3	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	4	190548499	190548500	+	IGR	INS	-	TC	TC	rs62323849		TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr4:190548499_190548500insTC								None (None upstream) : FRG1 (313474 downstream)																							gtgtgtgtgtgtatgtCTTTCT	0.307													3	5	---	---	---	---					
Unknown	0	broad.mit.edu	37	5	6571881	6571884	+	IGR	DEL	GAAG	-	-			TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr5:6571881_6571884delGAAG								UBE2QL1 (79176 upstream) : LOC255167 (10403 downstream)																							agggaggagagaaggaaggaagga	0.000													2	4	---	---	---	---					
HSPB3	8988	broad.mit.edu	37	5	53751384	53751385	+	5'Flank	INS	-	A	A	rs143819651	by1000genomes	TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr5:53751384_53751385insA	uc003jph.1	+							NM_006308	NP_006299	Q12988	HSPB3_HUMAN	heat shock 27kDa protein 3						cell death|response to heat|response to unfolded protein	cytoplasm|nucleus					0		Lung NSC(810;0.00104)				GTGCTAAATGCACTGGGAAACA	0.446													4	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	6	132083054	132083055	+	IGR	INS	-	TCCT	TCCT	rs4053155		TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr6:132083054_132083055insTCCT								ENPP3 (14505 upstream) : ENPP1 (46101 downstream)																							TTTTAAGTAGAtccttccttcc	0.158													3	5	---	---	---	---					
SRRT	51593	broad.mit.edu	37	7	100473251	100473274	+	In_Frame_Del	DEL	GACAAGTTCAGAAGAGAGCGCAGC	-	-			TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chr7:100473251_100473274delGACAAGTTCAGAAGAGAGCGCAGC	uc003uwy.2	+	3	308_331	c.40_63delGACAAGTTCAGAAGAGAGCGCAGC	c.(40-63)GACAAGTTCAGAAGAGAGCGCAGCdel	p.DKFRRERS14del	SRRT_uc010lhl.1_In_Frame_Del_p.DKFRRERS14del|SRRT_uc003uxa.2_In_Frame_Del_p.DKFRRERS14del|SRRT_uc003uwz.2_In_Frame_Del_p.DKFRRERS14del	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	14_21	Arg-rich.				cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2						AAGGCGCAGGGACAAGTTCAGAAGAGAGCGCAGCGACTACGACC	0.580													39	104	---	---	---	---					
Unknown	0	broad.mit.edu	37	X	53043948	53043949	+	IGR	DEL	AA	-	-			TCGA-BJ-A0Z2-01A-11D-A10S-08	TCGA-BJ-A0Z2-10A-01D-A10S-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dd5eea1-42a1-4e8b-99ac-20399cc7e15c	6f8f241c-648e-42c0-8660-600b58036c3a	g.chrX:53043948_53043949delAA								FAM156A (106365 upstream) : GPR173 (34557 downstream)																							agaccttgccaaaaaaaaaaaa	0.000													3	5	---	---	---	---					
