Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZC3H11A	9877	broad.mit.edu	37	1	203818917	203818917	+	Missense_Mutation	SNP	C	G	G			TCGA-DJ-A1QQ-01A-11D-A14W-08	TCGA-DJ-A1QQ-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	a54ee9b6-3aa0-4fe0-a688-45253b19a04c	9ea5111c-09c3-4c4a-ba2c-6adf77f634ee	g.chr1:203818917C>G	uc001hac.2	+	17	2318	c.1702C>G	c.(1702-1704)CAG>GAG	p.Q568E	ZC3H11A_uc001had.2_Missense_Mutation_p.Q568E|ZC3H11A_uc001hae.2_Missense_Mutation_p.Q568E|ZC3H11A_uc001haf.2_Missense_Mutation_p.Q568E|ZC3H11A_uc010pqm.1_Missense_Mutation_p.Q514E|ZC3H11A_uc001hag.1_Missense_Mutation_p.Q568E	NM_014827	NP_055642	O75152	ZC11A_HUMAN	zinc finger CCCH-type containing 11A	568							nucleic acid binding|protein binding|zinc ion binding			lung(1)|central_nervous_system(1)	2	all_cancers(21;0.0904)|all_epithelial(62;0.234)		BRCA - Breast invasive adenocarcinoma(75;0.109)			GAAGCACATGCAGAAACAGCA	0.463000													74	104	---	---	---	---	0	0	0.139131	0	0
MMP3	4314	broad.mit.edu	37	11	102711322	102711322	+	Missense_Mutation	SNP	T	A	A			TCGA-DJ-A1QQ-01A-11D-A14W-08	TCGA-DJ-A1QQ-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	a54ee9b6-3aa0-4fe0-a688-45253b19a04c	9ea5111c-09c3-4c4a-ba2c-6adf77f634ee	g.chr11:102711322T>A	uc001phj.1	-	5	693	c.628A>T	c.(628-630)ACC>TCC	p.T210S		NM_002422	NP_002413	P08254	MMP3_HUMAN	matrix metalloproteinase 3 preproprotein	210					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			lung(1)|kidney(1)	2		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0142)	Marimastat(DB00786)|Simvastatin(DB00641)	AATAAATTGGTCCCTATTTAA	0.388000													18	48	---	---	---	---	0	0	0.175082	0	0
MYO9A	4649	broad.mit.edu	37	15	72190581	72190581	+	Missense_Mutation	SNP	A	T	T			TCGA-DJ-A1QQ-01A-11D-A14W-08	TCGA-DJ-A1QQ-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	a54ee9b6-3aa0-4fe0-a688-45253b19a04c	9ea5111c-09c3-4c4a-ba2c-6adf77f634ee	g.chr15:72190581A>T	uc002atl.3	-	25	4736	c.4263T>A	c.(4261-4263)TTT>TTA	p.F1421L	MYO9A_uc010biq.2_Missense_Mutation_p.F1041L|MYO9A_uc002atn.1_Missense_Mutation_p.F1402L|MYO9A_uc002atk.2_Missense_Mutation_p.F145L|MYO9A_uc002atm.1_Missense_Mutation_p.F145L	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	1421	Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						GGGGGATATAAAAAAAAGTAG	0.398000													35	39	---	---	---	---	0	0	0.064281	0	0
PPL	5493	broad.mit.edu	37	16	4934851	4934851	+	Missense_Mutation	SNP	T	C	C			TCGA-DJ-A1QQ-01A-11D-A14W-08	TCGA-DJ-A1QQ-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	a54ee9b6-3aa0-4fe0-a688-45253b19a04c	9ea5111c-09c3-4c4a-ba2c-6adf77f634ee	g.chr16:4934851T>C	uc002cyd.1	-	22	3895	c.3805A>G	c.(3805-3807)ATC>GTC	p.I1269V		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	1269	Potential.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						AGCTGGTAGATCTCTAAATCA	0.507000													10	168	---	---	---	---	0	0	0.069234	0	0
HERC2P4	440362	broad.mit.edu	37	16	32163869	32163869	+	RNA	SNP	C	T	T			TCGA-DJ-A1QQ-01A-11D-A14W-08	TCGA-DJ-A1QQ-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	a54ee9b6-3aa0-4fe0-a688-45253b19a04c	9ea5111c-09c3-4c4a-ba2c-6adf77f634ee	g.chr16:32163869C>T	uc002ecx.2	-	1		c.6G>A				NR_002827				Homo sapiens hect domain and RLD 2 pseudogene 4, mRNA (cDNA clone IMAGE:5416019).												0						GGGAGTGCAGCGTGCACAGCA	0.617000													6	49	---	---	---	---	0	0	0.038147	0	0
PKD1L2	114780	broad.mit.edu	37	16	81232604	81232604	+	Silent	SNP	G	A	A			TCGA-DJ-A1QQ-01A-11D-A14W-08	TCGA-DJ-A1QQ-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	a54ee9b6-3aa0-4fe0-a688-45253b19a04c	9ea5111c-09c3-4c4a-ba2c-6adf77f634ee	g.chr16:81232604G>A	uc002fgh.1	-	7	1206	c.1206C>T	c.(1204-1206)GGC>GGT	p.G402G	PKD1L2_uc002fgj.2_Silent_p.G402G	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	402	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						ACGGTAGCGAGCCCTTTTGGG	0.532000													38	56	---	---	---	---	0	0	0.080422	0	0
CACNB1	782	broad.mit.edu	37	17	37333711	37333711	+	Silent	SNP	A	G	G			TCGA-DJ-A1QQ-01A-11D-A14W-08	TCGA-DJ-A1QQ-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	a54ee9b6-3aa0-4fe0-a688-45253b19a04c	9ea5111c-09c3-4c4a-ba2c-6adf77f634ee	g.chr17:37333711A>G	uc002hrm.1	-	13	1377	c.1224T>C	c.(1222-1224)TAT>TAC	p.Y408Y	CACNB1_uc002hrl.1_Silent_p.Y180Y|CACNB1_uc002hrn.2_Silent_p.Y408Y|CACNB1_uc002hro.2_Silent_p.Y453Y	NM_000723	NP_000714	Q02641	CACB1_HUMAN	calcium channel, voltage-dependent, beta 1	408					axon guidance	voltage-gated calcium channel complex				large_intestine(1)|ovary(1)	2					Ibutilide(DB00308)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Verapamil(DB00661)	TGGCCTTCCAATAGGCTTCCA	0.612000													11	17	---	---	---	---	0	0	0.093190	0	0
OR7G3	390883	broad.mit.edu	37	19	9236922	9236922	+	Silent	SNP	A	G	G			TCGA-DJ-A1QQ-01A-11D-A14W-08	TCGA-DJ-A1QQ-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	a54ee9b6-3aa0-4fe0-a688-45253b19a04c	9ea5111c-09c3-4c4a-ba2c-6adf77f634ee	g.chr19:9236922A>G	uc010xkl.1	-	1	705	c.705T>C	c.(703-705)TAT>TAC	p.Y235Y		NM_001001958	NP_001001958	Q8NG95	OR7G3_HUMAN	olfactory receptor, family 7, subfamily G,	235	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						AAAAAGCTTTATACTTTCCAC	0.448000													27	140	---	---	---	---	0	0	0.134883	0	0
SCN5A	6331	broad.mit.edu	37	3	38651439	38651439	+	Silent	SNP	C	T	T			TCGA-DJ-A1QQ-01A-11D-A14W-08	TCGA-DJ-A1QQ-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	a54ee9b6-3aa0-4fe0-a688-45253b19a04c	9ea5111c-09c3-4c4a-ba2c-6adf77f634ee	g.chr3:38651439C>T	uc003cio.2	-	7	914	c.720G>A	c.(718-720)GTG>GTA	p.V240V	SCN5A_uc003cin.2_Silent_p.V240V|SCN5A_uc003cil.3_Silent_p.V240V|SCN5A_uc010hhi.2_Silent_p.V240V|SCN5A_uc010hhk.2_Silent_p.V240V|SCN5A_uc011ayr.1_Silent_p.V240V|SCN5A_uc010hhl.1_Silent_p.V63V	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	240					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TCAGGGCCCCCACGATGGTCT	0.617000													17	54	---	---	---	---	0	0	0.146539	0	0
SLIT2	9353	broad.mit.edu	37	4	20555525	20555525	+	Missense_Mutation	SNP	G	C	C			TCGA-DJ-A1QQ-01A-11D-A14W-08	TCGA-DJ-A1QQ-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	a54ee9b6-3aa0-4fe0-a688-45253b19a04c	9ea5111c-09c3-4c4a-ba2c-6adf77f634ee	g.chr4:20555525G>C	uc003gpr.1	+	26	2863	c.2659G>C	c.(2659-2661)GCT>CCT	p.A887P	SLIT2_uc003gps.1_Missense_Mutation_p.A879P	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	887	LRRCT 4.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						TGCTCGTTGTGCTGGTCCTGG	0.408000													4	94	---	---	---	---	0	0	0.150653	0	0
ADAMTS19	171019	broad.mit.edu	37	5	128956351	128956351	+	Missense_Mutation	SNP	G	C	C			TCGA-DJ-A1QQ-01A-11D-A14W-08	TCGA-DJ-A1QQ-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	a54ee9b6-3aa0-4fe0-a688-45253b19a04c	9ea5111c-09c3-4c4a-ba2c-6adf77f634ee	g.chr5:128956351G>C	uc003kvb.1	+	9	1501	c.1501G>C	c.(1501-1503)GAT>CAT	p.D501H	ADAMTS19_uc010jdh.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	501	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		ATCGTGTGCTGATGGTCTTCA	0.358000													8	111	---	---	---	---	0	0	0.038147	0	0
CANX	821	broad.mit.edu	37	5	179150714	179150714	+	Missense_Mutation	SNP	G	T	T			TCGA-DJ-A1QQ-01A-11D-A14W-08	TCGA-DJ-A1QQ-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	a54ee9b6-3aa0-4fe0-a688-45253b19a04c	9ea5111c-09c3-4c4a-ba2c-6adf77f634ee	g.chr5:179150714G>T	uc003mkk.2	+	12	1629	c.1452G>T	c.(1450-1452)TGG>TGT	p.W484C	CANX_uc011dgp.1_Missense_Mutation_p.W519C|CANX_uc003mkl.2_Missense_Mutation_p.W484C|CANX_uc011dgq.1_Missense_Mutation_p.W376C	NM_001746	NP_001737	P27824	CALX_HUMAN	calnexin precursor	484	Helical; (Potential).				post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein secretion	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane|melanosome	calcium ion binding|sugar binding|unfolded protein binding				0	all_cancers(89;0.000129)|all_epithelial(37;5.59e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0413)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Reteplase(DB00015)|Tenecteplase(DB00031)	CGTGGCTGTGGGTAGTCTATA	0.458000													32	80	---	---	---	---	5.90632e-09	7.49649e-09	0.163468	1	0
HLA-DQB2	3120	broad.mit.edu	37	6	32726818	32726818	+	Missense_Mutation	SNP	G	C	C	rs34554556		TCGA-DJ-A1QQ-01A-11D-A14W-08	TCGA-DJ-A1QQ-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	a54ee9b6-3aa0-4fe0-a688-45253b19a04c	9ea5111c-09c3-4c4a-ba2c-6adf77f634ee	g.chr6:32726818G>C	uc003oby.3	-	3	538	c.455C>G	c.(454-456)GCC>GGC	p.A152G	HLA-DQB2_uc003obz.2_Missense_Mutation_p.A152G	NR_003937		Q5SR06	Q5SR06_HUMAN	SubName: Full=Major histocompatibility complex, class II, DQ beta 2; SubName: Full=Putative uncharacterized protein ENSP00000372579;	152					antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|immune response	integral to membrane|MHC class II protein complex					0						TTTGATCTGGGCTGGATAGAA	0.567000													3	65	---	---	---	---	0	0	0.115264	0	0
VPS52	6293	broad.mit.edu	37	6	33232649	33232649	+	Missense_Mutation	SNP	C	T	T			TCGA-DJ-A1QQ-01A-11D-A14W-08	TCGA-DJ-A1QQ-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	a54ee9b6-3aa0-4fe0-a688-45253b19a04c	9ea5111c-09c3-4c4a-ba2c-6adf77f634ee	g.chr6:33232649C>T	uc003odm.1	-	13	1520	c.1310G>A	c.(1309-1311)TGC>TAC	p.C437Y	VPS52_uc003odn.1_Missense_Mutation_p.C248Y	NM_022553	NP_072047	Q8N1B4	VPS52_HUMAN	vacuolar protein sorting 52	437					protein transport	endosome membrane|Golgi apparatus				ovary(4)|skin(1)	5						GGCATCGTAGCAGTCAGCTAG	0.438000													11	212	---	---	---	---	0	0	0.069234	0	0
C6orf97	80129	broad.mit.edu	37	6	151914317	151914317	+	Missense_Mutation	SNP	C	T	T			TCGA-DJ-A1QQ-01A-11D-A14W-08	TCGA-DJ-A1QQ-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	a54ee9b6-3aa0-4fe0-a688-45253b19a04c	9ea5111c-09c3-4c4a-ba2c-6adf77f634ee	g.chr6:151914317C>T	uc003qol.2	+	8	1458	c.1369C>T	c.(1369-1371)CGG>TGG	p.R457W		NM_025059	NP_079335	Q8IYT3	CF097_HUMAN	hypothetical protein LOC80129	457											0		Ovarian(120;0.126)	BRCA - Breast invasive adenocarcinoma(37;0.111)	OV - Ovarian serous cystadenocarcinoma(155;1.48e-10)		CTTTGACATGCGGCTGGACGT	0.443000													7	69	---	---	---	---	0	0	0.038147	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T			TCGA-DJ-A1QQ-01A-11D-A14W-08	TCGA-DJ-A1QQ-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	a54ee9b6-3aa0-4fe0-a688-45253b19a04c	9ea5111c-09c3-4c4a-ba2c-6adf77f634ee	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				25	43	---	---	---	---	0	0	0.108266	0	0
EPPK1	83481	broad.mit.edu	37	8	144940615	144940615	+	Silent	SNP	G	A	A			TCGA-DJ-A1QQ-01A-11D-A14W-08	TCGA-DJ-A1QQ-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	a54ee9b6-3aa0-4fe0-a688-45253b19a04c	9ea5111c-09c3-4c4a-ba2c-6adf77f634ee	g.chr8:144940615G>A	uc003zaa.1	-	2	14830	c.14817C>T	c.(14815-14817)ACC>ACT	p.T4939T		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	4939	Plectin 62.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TGACGAAGCCGGTGGCCGCCT	0.716000													4	39	---	---	---	---	0	0	0.150653	0	0
LOC442421	442421	broad.mit.edu	37	9	66500841	66500841	+	RNA	SNP	C	T	T			TCGA-DJ-A1QQ-01A-11D-A14W-08	TCGA-DJ-A1QQ-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	a54ee9b6-3aa0-4fe0-a688-45253b19a04c	9ea5111c-09c3-4c4a-ba2c-6adf77f634ee	g.chr9:66500841C>T	uc004aed.1	+	3		c.934C>T								Homo sapiens similar to prostaglandin E receptor 4, subtype EP4; PGE receptor, EP4 subtype; prostaglandin E2 receptor, mRNA (cDNA clone IMAGE:5288780).												0						CCACCTGGTGCCCAGGGCTCC	0.632000													5	28	---	---	---	---	0	0	0.029380	0	0
ZNF503	84858	broad.mit.edu	37	10	77158996	77159007	+	In_Frame_Del	DEL	GGCCGTTAGCGA	-	-			TCGA-DJ-A1QQ-01A-11D-A14W-08	TCGA-DJ-A1QQ-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	a54ee9b6-3aa0-4fe0-a688-45253b19a04c	9ea5111c-09c3-4c4a-ba2c-6adf77f634ee	g.chr10:77158996_77159007delGGCCGTTAGCGA	uc001jxg.2	-	2	1777_1788	c.1441_1452delTCGCTAACGGCC	c.(1441-1452)TCGCTAACGGCCdel	p.SLTA481del	C10orf41_uc010qlf.1_5'Flank	NM_032772	NP_116161	Q96F45	ZN503_HUMAN	zinc finger protein 503	481_484	Ala-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1	all_cancers(46;0.105)|all_epithelial(25;0.00449)|Prostate(51;0.0112)|Ovarian(15;0.088)					CAGCCGCGGCGGCCGTTAGCGAGGAGTGCACA	0.684													11	19	---	---	---	---					
Unknown	0	broad.mit.edu	37	11	86736370	86736371	+	IGR	INS	-	C	C	rs138581182	by1000genomes	TCGA-DJ-A1QQ-01A-11D-A14W-08	TCGA-DJ-A1QQ-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	a54ee9b6-3aa0-4fe0-a688-45253b19a04c	9ea5111c-09c3-4c4a-ba2c-6adf77f634ee	g.chr11:86736370_86736371insC								FZD4 (69937 upstream) : TMEM135 (12694 downstream)																							agagtgagactccatctcaaaa	0.134													2	4	---	---	---	---					
PRB2	653247	broad.mit.edu	37	12	11546506	11546508	+	In_Frame_Del	DEL	TTG	-	-			TCGA-DJ-A1QQ-01A-11D-A14W-08	TCGA-DJ-A1QQ-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	a54ee9b6-3aa0-4fe0-a688-45253b19a04c	9ea5111c-09c3-4c4a-ba2c-6adf77f634ee	g.chr12:11546506_11546508delTTG	uc010shk.1	-	3	539_541	c.504_506delCAA	c.(502-507)AACAAG>AAG	p.N168del		NM_006248	NP_006239			proline-rich protein BstNI subfamily 2												0		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			ACTTCGGGACTTGTTGTCTCCTT	0.596													9	971	---	---	---	---					
Unknown	0	broad.mit.edu	37	12	74151336	74151337	+	IGR	INS	-	GAAG	GAAG	rs143357657	by1000genomes	TCGA-DJ-A1QQ-01A-11D-A14W-08	TCGA-DJ-A1QQ-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	a54ee9b6-3aa0-4fe0-a688-45253b19a04c	9ea5111c-09c3-4c4a-ba2c-6adf77f634ee	g.chr12:74151336_74151337insGAAG								None (None upstream) : ATXN7L3B (780214 downstream)																							GAGTGAGTTATgaaggaaggaa	0.277													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	12	77054675	77054676	+	IGR	INS	-	A	A	rs34680604		TCGA-DJ-A1QQ-01A-11D-A14W-08	TCGA-DJ-A1QQ-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	a54ee9b6-3aa0-4fe0-a688-45253b19a04c	9ea5111c-09c3-4c4a-ba2c-6adf77f634ee	g.chr12:77054675_77054676insA								OSBPL8 (101086 upstream) : ZDHHC17 (103178 downstream)																							TAATAGGTGttaaaaaaaaaaa	0.386													3	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	19	50364344	50364345	+	IGR	INS	-	C	C	rs143744424	by1000genomes	TCGA-DJ-A1QQ-01A-11D-A14W-08	TCGA-DJ-A1QQ-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	a54ee9b6-3aa0-4fe0-a688-45253b19a04c	9ea5111c-09c3-4c4a-ba2c-6adf77f634ee	g.chr19:50364344_50364345insC								PTOV1 (345 upstream) : PNKP (117 downstream)																							CCTCGGTAGGGCCCCACCTTTT	0.614													5	6	---	---	---	---					
KLK1	3816	broad.mit.edu	37	19	51327164	51327164	+	5'Flank	DEL	C	-	-			TCGA-DJ-A1QQ-01A-11D-A14W-08	TCGA-DJ-A1QQ-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	a54ee9b6-3aa0-4fe0-a688-45253b19a04c	9ea5111c-09c3-4c4a-ba2c-6adf77f634ee	g.chr19:51327164delC	uc002ptk.1	-						KLK1_uc010ycg.1_5'Flank	NM_002257	NP_002248	P06870	KLK1_HUMAN	kallikrein 1 preproprotein						proteolysis	nucleus	serine-type endopeptidase activity				0		all_neural(266;0.0199)		OV - Ovarian serous cystadenocarcinoma(262;0.00224)|GBM - Glioblastoma multiforme(134;0.00399)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGGACAATTGCCCCCCCCCCC	0.637													4	3	---	---	---	---					
Unknown	0	broad.mit.edu	37	2	114552156	114552159	+	IGR	DEL	GAAG	-	-			TCGA-DJ-A1QQ-01A-11D-A14W-08	TCGA-DJ-A1QQ-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	a54ee9b6-3aa0-4fe0-a688-45253b19a04c	9ea5111c-09c3-4c4a-ba2c-6adf77f634ee	g.chr2:114552156_114552159delGAAG								SLC35F5 (37756 upstream) : ACTR3 (95378 downstream)																							ggaagggaaagaaggaaggaagga	0.000													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	8	144474196	144474199	+	IGR	DEL	TCAT	-	-	rs36189950		TCGA-DJ-A1QQ-01A-11D-A14W-08	TCGA-DJ-A1QQ-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	a54ee9b6-3aa0-4fe0-a688-45253b19a04c	9ea5111c-09c3-4c4a-ba2c-6adf77f634ee	g.chr8:144474196_144474199delTCAT								RHPN1 (7807 upstream) : MAFA (37316 downstream)																							atccatccactcatccatccatcc	0.000													3	6	---	---	---	---					
