Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
JMJD1C	221037	broad.mit.edu	37	10	64973913	64973913	+	Nonsense_Mutation	SNP	T	A	A			TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr10:64973913T>A	uc001jmn.2	-	8	2314	c.2014A>T	c.(2014-2016)AGA>TGA	p.R672*	JMJD1C_uc001jml.2_Nonsense_Mutation_p.R453*|JMJD1C_uc001jmm.2_Nonsense_Mutation_p.R384*|JMJD1C_uc010qiq.1_Nonsense_Mutation_p.R490*|JMJD1C_uc009xpi.2_Nonsense_Mutation_p.R490*|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc001jmp.1_Nonsense_Mutation_p.R384*	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	672					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					TTTGCCAATCTTCTTTCACCA	0.388000													21	95	---	---	---	---	0	0	0.002780	0	0
GLRX3	10539	broad.mit.edu	37	10	131943568	131943568	+	Silent	SNP	A	G	G			TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr10:131943568A>G	uc001lkm.1	+	2	208	c.186A>G	c.(184-186)CAA>CAG	p.Q62Q	GLRX3_uc001lkn.1_Silent_p.Q62Q|GLRX3_uc001lko.2_RNA	NM_006541	NP_006532	O76003	GLRX3_HUMAN	glutaredoxin 3	62	Thioredoxin.				cell redox homeostasis|negative regulation of cardiac muscle hypertrophy|regulation of the force of heart contraction	cell cortex	electron carrier activity|iron-sulfur cluster binding|metal ion binding|protein disulfide oxidoreductase activity				0		all_cancers(35;9.59e-07)|all_epithelial(44;1.48e-06)|Lung NSC(174;0.00566)|all_lung(145;0.00949)|Colorectal(57;0.142)|all_neural(114;0.16)|Breast(234;0.173)|Glioma(114;0.222)		OV - Ovarian serous cystadenocarcinoma(35;0.00218)		AACTCCCTCAAGTTTCATTTG	0.348000													3	57	---	---	---	---	0	0	0.004672	0	0
TSPAN32	10077	broad.mit.edu	37	11	2334910	2334910	+	Silent	SNP	C	T	T	rs147630481	by1000genomes	TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr11:2334910C>T	uc001lvy.1	+	5	518	c.381C>T	c.(379-381)TAC>TAT	p.Y127Y	TSPAN32_uc001lvx.1_Silent_p.Y186Y|TSPAN32_uc009ydk.1_Silent_p.Y137Y|TSPAN32_uc010qxk.1_Silent_p.Y162Y|TSPAN32_uc009ydl.1_RNA|TSPAN32_uc001lvz.1_Silent_p.Y97Y|TSPAN32_uc001lwb.1_Silent_p.Y97Y|TSPAN32_uc001lwc.1_Silent_p.Y72Y|TSPAN32_uc001lwd.1_5'Flank	NM_139022	NP_620591	Q96QS1	TSN32_HUMAN	tumor-suppressing subtransferable candidate 6	127					cell-cell signaling	integral to membrane				central_nervous_system(1)	1		all_epithelial(84;4.89e-05)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.00791)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.000533)|LUSC - Lung squamous cell carcinoma(625;0.082)|Lung(200;0.153)		TGGACACCTACGACCTGGTAT	0.672000													8	14	---	---	---	---	0	0	0.010729	0	0
AHNAK	79026	broad.mit.edu	37	11	62284755	62284755	+	Missense_Mutation	SNP	T	C	C			TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr11:62284755T>C	uc001ntl.2	-	5	17434	c.17134A>G	c.(17134-17136)ATC>GTC	p.I5712V	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	5712	Nuclear localization signal (Potential).				nervous system development	nucleus	protein binding	p.I5712T(1)		ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				GGCATTTTGATCTTGGACTTT	0.483000													3	149	---	---	---	---	0	0	0.004672	0	0
COL4A1	1282	broad.mit.edu	37	13	110844602	110844602	+	Missense_Mutation	SNP	C	A	A			TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr13:110844602C>A	uc001vqw.3	-	24	1617	c.1495G>T	c.(1495-1497)GAC>TAC	p.D499Y	COL4A1_uc010agl.2_Intron	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	499	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			AAACCTCTGTCGCCCTTGGCC	0.498000													9	74	---	---	---	---	0.000274275	0.000444064	0.004482	1	0
CTAGE5	4253	broad.mit.edu	37	14	39777757	39777757	+	Missense_Mutation	SNP	G	A	A			TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr14:39777757G>A	uc001wvg.3	+	13	1495	c.1159G>A	c.(1159-1161)GAA>AAA	p.E387K	CTAGE5_uc010tqe.1_Missense_Mutation_p.E349K|CTAGE5_uc001wuz.3_Missense_Mutation_p.E375K|CTAGE5_uc001wuy.3_Missense_Mutation_p.E307K|CTAGE5_uc001wvb.3_Missense_Mutation_p.E358K|CTAGE5_uc001wvc.3_Missense_Mutation_p.E332K|CTAGE5_uc001wva.3_Missense_Mutation_p.E358K|CTAGE5_uc001wve.1_Missense_Mutation_p.E363K|CTAGE5_uc001wvh.3_Missense_Mutation_p.E387K|CTAGE5_uc001wvf.3_Missense_Mutation_p.E312K|CTAGE5_uc001wvi.3_Missense_Mutation_p.E392K|CTAGE5_uc010amz.2_Missense_Mutation_p.E3K|CTAGE5_uc001wvj.3_Missense_Mutation_p.E358K	NM_005930	NP_005921	O15320	CTGE5_HUMAN	CTAGE family, member 5 isoform 1	387	Potential.						enzyme activator activity|protein binding				0	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0475)		AGTAATGACTGAATTATATCA	0.284000													5	100	---	---	---	---	0	0	0.001168	0	0
SLC8A3	6547	broad.mit.edu	37	14	70522512	70522512	+	Splice_Site	SNP	C	T	T			TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr14:70522512C>T	uc001xly.2	-	4	2660	c.1906_splice	c.e4+1	p.D636_splice	SLC8A3_uc001xlu.2_Intron|SLC8A3_uc001xlv.2_Intron|SLC8A3_uc001xlw.2_Splice_Site_p.D636_splice|SLC8A3_uc001xlx.2_Splice_Site_p.D637_splice|SLC8A3_uc001xlz.2_Intron|SLC8A3_uc010ara.2_Intron|SLC8A3_uc001xma.2_Intron	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium						cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		ACACCTCTTACCTGGAGATAA	0.403000													15	16	---	---	---	---	0	0	0.004990	0	0
SERPINA1	5265	broad.mit.edu	37	14	94847272	94847272	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr14:94847272G>A	uc001ycx.3	-	3	1114	c.853C>T	c.(853-855)CAG>TAG	p.Q285*	SERPINA1_uc001ycw.3_RNA|SERPINA1_uc010auw.2_Nonsense_Mutation_p.Q285*|SERPINA1_uc010aux.2_Nonsense_Mutation_p.Q285*|SERPINA1_uc001ycy.3_Nonsense_Mutation_p.Q285*|SERPINA1_uc010auy.2_Nonsense_Mutation_p.Q285*|SERPINA1_uc001ycz.3_Nonsense_Mutation_p.Q285*|SERPINA1_uc010auz.2_Nonsense_Mutation_p.Q285*|SERPINA1_uc010ava.2_Nonsense_Mutation_p.Q285*|SERPINA1_uc001ydb.3_Nonsense_Mutation_p.Q285*|SERPINA1_uc010avb.2_Nonsense_Mutation_p.Q285*|SERPINA1_uc001ydc.3_Nonsense_Mutation_p.Q285*|SERPINA1_uc001yda.1_Nonsense_Mutation_p.Q285*	NM_000295	NP_000286	P01009	A1AT_HUMAN	serine proteinase inhibitor, clade A, member 1	285					acute-phase response|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen|proteinaceous extracellular matrix	protease binding|serine-type endopeptidase inhibitor activity			skin(1)	1		all_cancers(154;0.0649)|all_epithelial(191;0.223)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)	Alpha-1-proteinase inhibitor(DB00058)	TCCAGGTGCTGTAGTTTCCCC	0.507000									Alpha-1-Antitrypsin_Deficiency				12	135	---	---	---	---	0	0	0.001855	0	0
Unknown	0	broad.mit.edu	37	15	23108883	23108883	+	RNA	SNP	T	C	C	rs3178813	by1000genomes	TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr15:23108883T>C	uc001yvf.2	-	3		c.245A>G								Homo sapiens cDNA clone IMAGE:5275816.																		TTCGACACTATCATCTGCAGA	0.378000													3	55	---	---	---	---	0	0	0.004672	0	0
SPATA8	145946	broad.mit.edu	37	15	97328316	97328316	+	Missense_Mutation	SNP	G	A	A			TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr15:97328316G>A	uc002bue.2	+	3	497	c.287G>A	c.(286-288)AGT>AAT	p.S96N	uc010urp.1_5'Flank|uc002bud.1_5'Flank	NM_173499	NP_775770	Q6RVD6	SPAT8_HUMAN	spermatogenesis associated 8	96										ovary(1)|skin(1)	2	Melanoma(26;0.0142)|Lung NSC(78;0.041)|all_lung(78;0.0468)		OV - Ovarian serous cystadenocarcinoma(32;0.0718)			AACAGGAGAAGTGTCCTGTTT	0.473000													56	68	---	---	---	---	0	0	0.014410	0	0
APOB48R	55911	broad.mit.edu	37	16	28507219	28507219	+	Missense_Mutation	SNP	C	T	T			TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr16:28507219C>T	uc002dqb.1	+	2	867	c.857C>T	c.(856-858)ACC>ATC	p.T286I	uc010vct.1_Intron|APOB48R_uc010byg.1_Intron	NM_018690	NP_061160	Q0VD83	APOBR_HUMAN	apolipoprotein B48 receptor	286	Glu-rich.				cholesterol metabolic process|lipid transport	chylomicron|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle					0						GCCAGGACAACCCCAGGTAGG	0.632000													11	16	---	---	---	---	0	0	0.008291	0	0
LONP2	83752	broad.mit.edu	37	16	48311247	48311247	+	Splice_Site	SNP	A	T	T			TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr16:48311247A>T	uc002efi.1	+	8	1331	c.1242_splice	c.e8-2	p.R414_splice	LONP2_uc010vgm.1_Splice_Site|LONP2_uc002efj.1_Splice_Site_p.R370_splice	NM_031490	NP_113678	Q86WA8	LONP2_HUMAN	peroxisomal LON protease-like						misfolded or incompletely synthesized protein catabolic process|protein targeting to peroxisome|signal peptide processing	nucleoid|peroxisomal matrix	ATP binding|ATP-dependent peptidase activity|enzyme binding|sequence-specific DNA binding|serine-type endopeptidase activity				0						TGCTTTCTCTAGGCGCACCTA	0.463000													4	85	---	---	---	---	0	0	0.009096	0	0
LONP2	83752	broad.mit.edu	37	16	48381506	48381506	+	Missense_Mutation	SNP	G	A	A			TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr16:48381506G>A	uc002efi.1	+	13	2116	c.2027G>A	c.(2026-2028)CGA>CAA	p.R676Q	LONP2_uc010vgm.1_RNA|LONP2_uc002efj.1_Missense_Mutation_p.R632Q	NM_031490	NP_113678	Q86WA8	LONP2_HUMAN	peroxisomal LON protease-like	676					misfolded or incompletely synthesized protein catabolic process|protein targeting to peroxisome|signal peptide processing	nucleoid|peroxisomal matrix	ATP binding|ATP-dependent peptidase activity|enzyme binding|sequence-specific DNA binding|serine-type endopeptidase activity				0						GAGGCGAGTCGAATGGATGGC	0.557000													4	100	---	---	---	---	0	0	0.000602	0	0
TP53	7157	broad.mit.edu	37	17	7572986	7572986	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr17:7572986G>A	uc002gim.2	-	11	1317	c.1123C>T	c.(1123-1125)CAG>TAG	p.Q375*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Intron|TP53_uc010cne.1_RNA|TP53_uc010cnf.1_3'UTR|TP53_uc010cng.1_3'UTR|TP53_uc002gii.1_Nonsense_Mutation_p.Q243*|TP53_uc010cnh.1_3'UTR|TP53_uc010cni.1_3'UTR|TP53_uc002gij.2_Nonsense_Mutation_p.Q375*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	375	Basic (repression of DNA-binding).|Interaction with CARM1.				activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.?(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GAGGTAGACTGACCCTTTTTG	0.527000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			6	142	---	---	---	---	0	0	0.001984	0	0
EVPL	2125	broad.mit.edu	37	17	74015142	74015142	+	Splice_Site	SNP	C	G	G			TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr17:74015142C>G	uc002jqi.2	-	11	1366	c.1138_splice	c.e11-1	p.A380_splice	EVPL_uc010wss.1_Splice_Site_p.A380_splice|EVPL_uc010wst.1_Splice_Site	NM_001988	NP_001979	Q92817	EVPL_HUMAN	envoplakin						keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			pancreas(2)|central_nervous_system(1)|skin(1)	4						TTTCCTCTGCCTGCCGGGGGC	0.657000													12	23	---	---	---	---	0	0	0.001855	0	0
C19orf57	79173	broad.mit.edu	37	19	14015679	14015679	+	Silent	SNP	G	A	A			TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr19:14015679G>A	uc002mxl.1	-	2	86	c.27C>T	c.(25-27)ACC>ACT	p.T9T	CC2D1A_uc002mxn.2_5'Flank|CC2D1A_uc002mxo.2_5'Flank|CC2D1A_uc002mxp.2_5'Flank|C19orf57_uc002mxm.1_Silent_p.T9T	NM_024323	NP_077299	Q0VDD7	CS057_HUMAN	hypothetical protein LOC79173	9					multicellular organismal development		protein binding			ovary(2)|upper_aerodigestive_tract(1)	3			OV - Ovarian serous cystadenocarcinoma(19;2e-21)			ACGTACCTGAGGTCCGCAGCT	0.413000													4	129	---	---	---	---	0	0	0.001168	0	0
PROKR2	128674	broad.mit.edu	37	20	5283032	5283032	+	Missense_Mutation	SNP	C	T	T	rs146544539		TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr20:5283032C>T	uc010zqw.1	-	2	809	c.809G>A	c.(808-810)CGC>CAC	p.R270H	PROKR2_uc010zqx.1_Missense_Mutation_p.R270H|PROKR2_uc010zqy.1_Missense_Mutation_p.R270H	NM_144773	NP_658986	Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	270	Cytoplasmic (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5						CGTCTTCCTGCGGCAGCGCAG	0.597000										HNSCC(71;0.22)			9	57	---	---	---	---	0	0	0.006214	0	0
CDH26	60437	broad.mit.edu	37	20	58558037	58558037	+	Silent	SNP	C	T	T			TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr20:58558037C>T	uc002ybe.2	+	5	753	c.453C>T	c.(451-453)TTC>TTT	p.F151F	CDH26_uc010zzy.1_RNA	NM_177980	NP_817089	Q8IXH8	CAD26_HUMAN	cadherin-like 26 isoform a	151	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|central_nervous_system(1)	4	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			CCTTGATTTTCAACATTAGGA	0.413000													9	199	---	---	---	---	0	0	0.006214	0	0
TMPRSS15	5651	broad.mit.edu	37	21	19770245	19770245	+	Missense_Mutation	SNP	A	T	T			TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr21:19770245A>T	uc002ykw.2	-	3	326	c.295T>A	c.(295-297)TCA>ACA	p.S99T		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	99	Extracellular (Potential).|SEA.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						AGATTGCTTGATAGAAAGATC	0.244000													3	9	---	---	---	---	0	0	0.004672	0	0
SLC4A7	9497	broad.mit.edu	37	3	27444776	27444776	+	Silent	SNP	C	G	G			TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr3:27444776C>G	uc003cdv.2	-	15	2219	c.2148G>C	c.(2146-2148)GTG>GTC	p.V716V	SLC4A7_uc011awu.1_RNA|SLC4A7_uc011awv.1_RNA|SLC4A7_uc003cdu.3_Silent_p.V597V|SLC4A7_uc011aww.1_Silent_p.V725V|SLC4A7_uc011awx.1_Silent_p.V712V|SLC4A7_uc011awy.1_Silent_p.V708V|SLC4A7_uc011awz.1_RNA|SLC4A7_uc011axa.1_Silent_p.V597V|SLC4A7_uc011axb.1_Silent_p.V712V|SLC4A7_uc010hfl.2_Silent_p.V266V|SLC4A7_uc003cdw.2_Silent_p.V592V	NM_003615	NP_003606	Q9Y6M7	S4A7_HUMAN	solute carrier family 4, sodium bicarbonate	716	Helical; (Potential).					apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|central_nervous_system(1)|skin(1)	5						TAATATAACACACAAGGCTGC	0.378000													6	145	---	---	---	---	0	0	0.001168	0	0
LOC729375	729375	broad.mit.edu	37	3	129821650	129821650	+	RNA	SNP	G	A	A	rs56088005	by1000genomes	TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr3:129821650G>A	uc003ene.2	-	2		c.266C>T			LOC729375_uc011ble.1_RNA					Homo sapiens cDNA FLJ42457 fis, clone BRACE2018700.												0						GGTTGCGGACGGTAAAGGCCA	0.667000													5	151	---	---	---	---	0	0	0.000602	0	0
NAALADL2	254827	broad.mit.edu	37	3	175455163	175455163	+	Silent	SNP	T	C	C			TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr3:175455163T>C	uc003fit.2	+	12	2053	c.1966T>C	c.(1966-1968)TTA>CTA	p.L656L		NM_207015	NP_996898	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	656	Extracellular (Potential).				proteolysis	integral to membrane	peptidase activity			pancreas(1)	1	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		TGATATAGCTTTAGAAGTTCA	0.313000													3	64	---	---	---	---	0	0	0.009096	0	0
GABRA6	2559	broad.mit.edu	37	5	161128522	161128522	+	Missense_Mutation	SNP	C	T	T			TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr5:161128522C>T	uc003lyu.2	+	9	1443	c.1105C>T	c.(1105-1107)CAT>TAT	p.H369Y	GABRA6_uc003lyv.2_Missense_Mutation_p.H140Y	NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	369	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CTCCAAATATCATCTGAAGAA	0.378000										TCGA Ovarian(5;0.080)			8	155	---	---	---	---	0	0	0.004482	0	0
BAI3	577	broad.mit.edu	37	6	69758224	69758224	+	Missense_Mutation	SNP	A	T	T			TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr6:69758224A>T	uc003pev.3	+	14	2703	c.2255A>T	c.(2254-2256)AAA>ATA	p.K752I	BAI3_uc010kak.2_Missense_Mutation_p.K752I	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	752	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				GTGTCATCAAAAGGTAAATAT	0.328000													5	47	---	---	---	---	0	0	0.001168	0	0
STK31	56164	broad.mit.edu	37	7	23871854	23871854	+	Missense_Mutation	SNP	G	C	C			TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr7:23871854G>C	uc003sws.3	+	24	2996	c.2929G>C	c.(2929-2931)GAG>CAG	p.E977Q	STK31_uc003swt.3_Missense_Mutation_p.E954Q|STK31_uc011jze.1_Missense_Mutation_p.E954Q|STK31_uc010kuq.2_Missense_Mutation_p.E954Q|STK31_uc003swv.1_Missense_Mutation_p.E143Q	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	977	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						GATGCCAAAGGAGCAATCAGT	0.358000													3	95	---	---	---	---	0	0	0.009096	0	0
ZAN	7455	broad.mit.edu	37	7	100352918	100352918	+	Missense_Mutation	SNP	G	T	T			TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr7:100352918G>T	uc003uwj.2	+	15	3359	c.3194G>T	c.(3193-3195)AGC>ATC	p.S1065I	ZAN_uc003uwk.2_Missense_Mutation_p.S1065I|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	1065	TIL 1.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CCCAGGCCTAGCTGTGGGCCC	0.562000													73	186	---	---	---	---	1.38806e-43	2.30215e-43	0.014410	1	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T			TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				32	87	---	---	---	---	0	0	0.004289	0	0
FAM110B	90362	broad.mit.edu	37	8	59058923	59058923	+	Missense_Mutation	SNP	C	T	T			TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr8:59058923C>T	uc003xtj.1	+	5	1014	c.134C>T	c.(133-135)CCC>CTC	p.P45L		NM_147189	NP_671722	Q8TC76	F110B_HUMAN	hypothetical protein LOC90362	45						microtubule organizing center|mitochondrion|nucleus				large_intestine(1)	1		all_epithelial(80;0.025)|all_lung(136;0.0274)|Lung NSC(129;0.0355)				GAGCCCAACCCCAAGAGGCTC	0.667000													9	42	---	---	---	---	0	0	0.010729	0	0
CA13	377677	broad.mit.edu	37	8	86193478	86193478	+	Missense_Mutation	SNP	T	G	G			TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr8:86193478T>G	uc003ydg.2	+	7	1031	c.689T>G	c.(688-690)CTC>CGC	p.L230R	CA13_uc003ydf.1_Intron	NM_198584	NP_940986	Q8N1Q1	CAH13_HUMAN	carbonic anhydrase XIII	230					one-carbon metabolic process		carbonate dehydratase activity|zinc ion binding				0						TTTCGCAGTCTCCTGTGCACA	0.458000													30	244	---	---	---	---	0	0	0.003271	0	0
IARS	3376	broad.mit.edu	37	9	95027811	95027811	+	Missense_Mutation	SNP	C	T	T			TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr9:95027811C>T	uc004art.1	-	15	1713	c.1456G>A	c.(1456-1458)GAA>AAA	p.E486K	IARS_uc004ars.1_Missense_Mutation_p.E331K|IARS_uc004aru.3_Missense_Mutation_p.E486K|IARS_uc010mqr.2_Missense_Mutation_p.E376K|IARS_uc010mqt.2_Intron	NM_013417	NP_038203	P41252	SYIC_HUMAN	isoleucine tRNA synthetase	486					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			ovary(1)|skin(1)	2					L-Isoleucine(DB00167)	TCTTCAAGTTCCGCCACTGAC	0.413000													7	213	---	---	---	---	0	0	0.004482	0	0
NCBP1	4686	broad.mit.edu	37	9	100409798	100409798	+	Silent	SNP	C	T	T			TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr9:100409798C>T	uc004axq.2	+	7	1095	c.636C>T	c.(634-636)CCC>CCT	p.P212P		NM_002486	NP_002477	Q09161	NCBP1_HUMAN	nuclear cap binding protein subunit 1, 80kDa	212	MIF4G.				gene silencing by RNA|histone mRNA metabolic process|mRNA 3'-end processing|mRNA capping|mRNA cleavage|mRNA export from nucleus|ncRNA metabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of mRNA 3'-end processing|positive regulation of viral transcription|regulation of translational initiation|spliceosomal snRNP assembly|termination of RNA polymerase II transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytosol|mRNA cap binding complex|nucleoplasm|ribonucleoprotein complex	protein binding|RNA cap binding			central_nervous_system(1)	1		Acute lymphoblastic leukemia(62;0.158)				CTCATGTACCCATGTTACAGG	0.284000													3	77	---	---	---	---	0	0	0.000602	0	0
OR13F1	138805	broad.mit.edu	37	9	107267381	107267381	+	Missense_Mutation	SNP	G	A	A	rs142994537		TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr9:107267381G>A	uc011lvm.1	+	1	838	c.838G>A	c.(838-840)GGA>AGA	p.G280R		NM_001004485	NP_001004485	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F,	280	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)|skin(1)	3						GGTGTATGCCGGACAAACCCC	0.428000													10	83	---	---	---	---	0	0	0.010729	0	0
SVEP1	79987	broad.mit.edu	37	9	113208159	113208159	+	Missense_Mutation	SNP	T	C	C			TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr9:113208159T>C	uc010mtz.2	-	26	4758	c.4421A>G	c.(4420-4422)GAT>GGT	p.D1474G	SVEP1_uc010mua.1_Missense_Mutation_p.D1474G	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	1474	Pentaxin.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						GCTGCCGTTATCAACTGCATA	0.453000													6	141	---	---	---	---	0	0	0.001168	0	0
HDAC8	55869	broad.mit.edu	37	X	71681859	71681859	+	Missense_Mutation	SNP	G	A	A			TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chrX:71681859G>A	uc004eau.2	-	9	1042	c.1000C>T	c.(1000-1002)CAT>TAT	p.H334Y	HDAC8_uc011mqe.1_Missense_Mutation_p.H191Y|HDAC8_uc011mqf.1_Missense_Mutation_p.H139Y|HDAC8_uc011mqg.1_Missense_Mutation_p.H243Y	NM_018486	NP_060956	Q9BY41	HDAC8_HUMAN	histone deacetylase 8	334					chromatin assembly or disassembly|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nuclear chromosome	histone deacetylase activity (H3-K16 specific)|metal ion binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription factor binding				0	Renal(35;0.156)				Vorinostat(DB02546)	CTTACCTCATGATCTGGGATC	0.483000													28	62	---	---	---	---	0	0	0.005443	0	0
ELAVL4	1996	broad.mit.edu	37	1	50572178	50572178	+	5'Flank	DEL	A	-	-	rs79810783		TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr1:50572178delA	uc001csb.2	+						ELAVL4_uc001cry.3_Intron|ELAVL4_uc001crz.3_Intron|ELAVL4_uc001csa.3_Intron|ELAVL4_uc001csc.3_5'Flank	NM_021952	NP_068771	P26378	ELAV4_HUMAN	ELAV-like 4 isoform 1						mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			ovary(1)|pancreas(1)	2						ATTGTGGCAGAAAAAAAAAAT	0.453													3	3	---	---	---	---					
SIKE1	80143	broad.mit.edu	37	1	115321810	115321811	+	Frame_Shift_Ins	INS	-	T	T			TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr1:115321810_115321811insT	uc001efo.3	-	3	440_441	c.360_361insA	c.(358-363)AAAGCGfs	p.K120fs	SIKE1_uc001efp.3_Frame_Shift_Ins_p.K124fs	NM_025073	NP_079349	Q9BRV8	SIKE1_HUMAN	suppressor of IKK epsilon isoform 2	120_121						cytosol	protein binding				0						GCATCCACCGCTTTTTTAGCAA	0.396													30	139	---	---	---	---					
MRPL38	64978	broad.mit.edu	37	17	73895623	73895623	+	Frame_Shift_Del	DEL	G	-	-			TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr17:73895623delG	uc010wso.1	-	7	1068	c.843delC	c.(841-843)TTCfs	p.F281fs	FBF1_uc002jqa.1_RNA|TRIM65_uc002jpx.2_5'Flank|MRPL38_uc002jpz.1_RNA	NM_032478	NP_115867	Q96DV4	RM38_HUMAN	mitochondrial ribosomal protein L38 precursor	281						actin cytoskeleton|mitochondrion|ribosome				pancreas(1)	1			all cancers(21;0.000154)|Epithelial(20;0.000156)|BRCA - Breast invasive adenocarcinoma(9;0.00936)|LUSC - Lung squamous cell carcinoma(166;0.154)			CGTCCTCAGAGAAGTCAATCG	0.617													10	35	---	---	---	---					
Unknown	0	broad.mit.edu	37	19	22655134	22655134	+	IGR	DEL	A	-	-			TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr19:22655134delA								ZNF98 (49986 upstream) : ZNF492 (161992 downstream)																							CATACTGGAGAAAAAAACCAT	0.378													2	4	---	---	---	---					
ALS2	57679	broad.mit.edu	37	2	202603435	202603435	+	Frame_Shift_Del	DEL	A	-	-			TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr2:202603435delA	uc002uyo.2	-	12	2731	c.2375delT	c.(2374-2376)TTCfs	p.F792fs	ALS2_uc002uyp.3_Frame_Shift_Del_p.F792fs|ALS2_uc010ftl.2_RNA	NM_020919	NP_065970	Q96Q42	ALS2_HUMAN	alsin isoform 1	792	DH.				cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			skin(5)|lung(1)|breast(1)	7						CATAACCAGGAAATTTGTAAT	0.383													9	53	---	---	---	---					
Unknown	0	broad.mit.edu	37	20	44374842	44374842	+	IGR	DEL	T	-	-	rs75273200		TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr20:44374842delT								SPINT4 (20507 upstream) : WFDC3 (28005 downstream)																							AGTATTGTAAttttttttttt	0.214													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	9	34923047	34923047	+	IGR	DEL	T	-	-			TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr9:34923047delT								C9orf144 (84464 upstream) : KIAA1045 (34474 downstream)																							TTTGTTTTTGTTTTTTttttt	0.308													3	3	---	---	---	---					
Unknown	0	broad.mit.edu	37	9	110220239	110220241	+	IGR	DEL	AAC	-	-	rs57160910		TCGA-EL-A3D6-01A-12D-A202-08	TCGA-EL-A3D6-10A-01D-A202-08									Somatic	Phase_I	Capture				Illumina GAIIx	354c1945-1933-45ff-a68b-a3c3ca0558d2	2131b331-eeb2-4b90-aae6-cd22b0b97b78	g.chr9:110220239_110220241delAAC								RAD23B (125770 upstream) : KLF4 (26894 downstream)																							aaaaaaaaaaaacaaaaaaacaa	0.167													2	4	---	---	---	---					
