Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SFRS4	6429	broad.mit.edu	37	1	29475685	29475685	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr1:29475685C>T	uc001bro.2	-	6	1095	c.722G>A	c.(721-723)CGG>CAG	p.R241Q	SFRS4_uc010ofy.1_Silent_p.P139P	NM_005626	NP_005617	Q08170	SRSF4_HUMAN	splicing factor, arginine/serine-rich 4	241	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|RNA binding				0		Colorectal(325;0.00161)|Breast(348;0.0364)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0529)|Lung NSC(340;0.0654)|all_lung(284;0.074)|Ovarian(437;0.104)|Medulloblastoma(700;0.151)		Colorectal(126;1.01e-07)|COAD - Colon adenocarcinoma(152;6.21e-06)|STAD - Stomach adenocarcinoma(196;0.0196)|BRCA - Breast invasive adenocarcinoma(304;0.0531)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.138)		TTTCTTgctccggctccgact	0.463000													13	124					0	0	0.020292	0	0
GJB5	2709	broad.mit.edu	37	1	35223072	35223072	+	Missense_Mutation	SNP	C	A	A			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr1:35223072C>A	uc001bxu.2	+	2	241	c.141C>A	c.(139-141)GAC>GAA	p.D47E	GJB4_uc001bxv.1_5'Flank	NM_005268	NP_005259	O95377	CXB5_HUMAN	gap junction protein, beta 5, 31.1kDa	47	Extracellular (Potential).				cell communication|epidermis development	connexon complex|integral to membrane				ovary(1)	1		Myeloproliferative disorder(586;0.0393)				GGAGTGATGACCACAAGGACT	0.592000													4	61					0.00024832	0.000260145	0.009096	1	0
ZNF691	51058	broad.mit.edu	37	1	43317094	43317094	+	Silent	SNP	C	A	A			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr1:43317094C>A	uc001cih.2	+	2	597	c.546C>A	c.(544-546)CTC>CTA	p.L182L	ZNF691_uc001cig.2_Silent_p.L155L|ZNF691_uc009vwm.2_Silent_p.L175L	NM_015911	NP_056995	Q5VV52	ZN691_HUMAN	zinc finger protein 691	186	C2H2-type 3.					nucleus	DNA binding|zinc ion binding			ovary(2)	2	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GCTCAGACCTCACCACGCACC	0.597000													16	54					4.7546e-09	5.36417e-09	0.028581	1	0
CACHD1	57685	broad.mit.edu	37	1	65143946	65143946	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr1:65143946G>A	uc001dbo.1	+	23	3149	c.3044G>A	c.(3043-3045)GGG>GAG	p.G1015E	CACHD1_uc001dbp.1_Missense_Mutation_p.G770E|CACHD1_uc001dbq.1_Missense_Mutation_p.G770E|CACHD1_uc010opa.1_Missense_Mutation_p.G259E	NM_020925	NP_065976	Q5VU97	CAHD1_HUMAN	cache domain containing 1	1066	Extracellular (Potential).				calcium ion transport	integral to membrane				ovary(2)	2						TGCTTCGGGGGGATTGTGGGA	0.473000													5	63					0	0	0.014758	0	0
FMO1	2326	broad.mit.edu	37	1	171247924	171247924	+	Missense_Mutation	SNP	A	T	T			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr1:171247924A>T	uc009wvz.2	+	5	677	c.541A>T	c.(541-543)ATA>TTA	p.I181L	FMO1_uc010pme.1_Missense_Mutation_p.I118L|FMO1_uc001ghl.2_Missense_Mutation_p.I181L|FMO1_uc001ghm.2_Missense_Mutation_p.I181L|FMO1_uc001ghn.2_Missense_Mutation_p.I181L	NM_002021	NP_002012	Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	181					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GCATCCAGATATATTTAAGGA	0.418000													41	81					0	0	0.086207	0	0
C1orf9	51430	broad.mit.edu	37	1	172558217	172558217	+	Missense_Mutation	SNP	T	G	G			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr1:172558217T>G	uc001giq.3	+	18	2292	c.1976T>G	c.(1975-1977)CTT>CGT	p.L659R	C1orf9_uc010pmm.1_Missense_Mutation_p.L659R|C1orf9_uc009wwd.2_Missense_Mutation_p.L615R|C1orf9_uc010pmn.1_Intron|C1orf9_uc010pmo.1_RNA	NM_014283	NP_055098	Q9UBS9	OSPT_HUMAN	chromosome 1 open reading frame 9 protein	659					multicellular organismal development|ossification	integral to membrane|rough endoplasmic reticulum membrane				ovary(2)	2		Breast(1374;0.212)		Colorectal(1306;3.98e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00544)		AAAGATTATCTTGTGTTAGCT	0.383000													29	52					0	0	0.108266	0	0
C1orf14	81626	broad.mit.edu	37	1	182921876	182921876	+	Silent	SNP	C	T	T			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr1:182921876C>T	uc001gpu.2	-	1	678	c.393G>A	c.(391-393)CTG>CTA	p.L131L	C1orf14_uc001gpv.2_5'UTR|C1orf14_uc010pnz.1_5'UTR|C1orf14_uc001gpw.2_5'UTR	NM_030933	NP_112195	Q9BZQ2	SHP1L_HUMAN	chromosome 1 open reading frame 14	203											0				Colorectal(1306;1.64e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00267)		TACAGTCCTGCAGCACTTCGT	0.627000													7	22					0	0	0.029380	0	0
KIF21B	23046	broad.mit.edu	37	1	200973948	200973948	+	Silent	SNP	C	A	A	rs140945427		TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr1:200973948C>A	uc001gvs.1	-	6	1163	c.846G>T	c.(844-846)CGG>CGT	p.R282R	KIF21B_uc001gvr.1_Silent_p.R282R|KIF21B_uc009wzl.1_Silent_p.R282R|KIF21B_uc010ppn.1_Silent_p.R282R|KIF21B_uc001gvt.1_Silent_p.R65R	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	282	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						TAGCCCCTGTCCGCTTCAGCC	0.597000													20	47					5.35356e-11	6.11835e-11	0.076483	1	0
TMEM81	388730	broad.mit.edu	37	1	205053045	205053045	+	Missense_Mutation	SNP	A	C	C			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr1:205053045A>C	uc001hbt.2	-	1	544	c.404T>G	c.(403-405)TTC>TGC	p.F135C		NM_203376	NP_976310	Q6P7N7	TMM81_HUMAN	transmembrane protein 81 precursor	135	Ig-like.|Extracellular (Potential).					integral to membrane					0	all_cancers(21;0.144)|Breast(84;0.0437)		BRCA - Breast invasive adenocarcinoma(75;0.0923)			AAAGGGTTTGAAGACCTCATC	0.468000													29	88					0	0	0.034045	0	0
C10orf90	118611	broad.mit.edu	37	10	128193076	128193076	+	Missense_Mutation	SNP	C	G	G			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr10:128193076C>G	uc001ljq.2	-	3	814	c.693G>C	c.(691-693)GAG>GAC	p.E231D	C10orf90_uc001ljp.2_Missense_Mutation_p.E184D|C10orf90_uc010qum.1_Missense_Mutation_p.E328D|C10orf90_uc009yao.2_Missense_Mutation_p.E328D|C10orf90_uc001ljs.1_Missense_Mutation_p.E184D	NM_001004298	NP_001004298	Q96M02	CJ090_HUMAN	hypothetical protein LOC118611	231										ovary(1)|skin(1)	2		all_epithelial(44;4.51e-05)|all_lung(145;0.0068)|Lung NSC(174;0.0105)|Colorectal(57;0.0848)|all_neural(114;0.0936)|Breast(234;0.203)		COAD - Colon adenocarcinoma(40;0.0442)|Colorectal(40;0.0479)		AAAAACTGGTCTCTTTGTCGT	0.557000											OREG0020616	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	64					0	0	0.055883	0	0
OR52B2	255725	broad.mit.edu	37	11	6190974	6190974	+	Missense_Mutation	SNP	T	A	A	rs35364339		TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr11:6190974T>A	uc010qzy.1	-	1	583	c.583A>T	c.(583-585)ACT>TCT	p.T195S		NM_001004052	NP_001004052	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B,	195	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATGTTAACAGTGATGTCAGCA	0.478000													8	22					0	0	0.038147	0	0
NUP160	23279	broad.mit.edu	37	11	47819410	47819410	+	Silent	SNP	A	C	C			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr11:47819410A>C	uc001ngm.2	-	27	3295	c.3210T>G	c.(3208-3210)GCT>GCG	p.A1070A	NUP160_uc009ylw.2_RNA	NM_015231	NP_056046	Q12769	NU160_HUMAN	nucleoporin 160kDa	1070					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7						CCACAGCTCTAGCACGTGACT	0.443000													30	93					0	0	0.034045	0	0
OR4C11	219429	broad.mit.edu	37	11	55371448	55371448	+	Missense_Mutation	SNP	C	A	A			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr11:55371448C>A	uc010rii.1	-	1	402	c.402G>T	c.(400-402)ATG>ATT	p.M134I		NM_001004700	NP_001004700	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C,	134	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CCTGCTGGCTCATGATGGTTG	0.463000													5	92					3.59834e-05	3.86163e-05	0.021553	1	0
CACNA2D4	93589	broad.mit.edu	37	12	2017181	2017181	+	Missense_Mutation	SNP	A	G	G			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr12:2017181A>G	uc001qjp.2	-	5	740	c.509T>C	c.(508-510)CTG>CCG	p.L170P	CACNA2D4_uc009zds.1_RNA|CACNA2D4_uc009zdt.1_Missense_Mutation_p.L170P	NM_172364	NP_758952	Q7Z3S7	CA2D4_HUMAN	voltage-gated calcium channel alpha(2)delta-4	170	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			ovary(1)	1	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		CTCGTTGATCAGGACCGAGTT	0.627000													3	69					0	0	0.004672	0	0
DDX47	51202	broad.mit.edu	37	12	12974592	12974592	+	Missense_Mutation	SNP	T	C	C			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr12:12974592T>C	uc001rav.2	+	7	972	c.374T>C	c.(373-375)GTG>GCG	p.V125A	DDX47_uc009zhw.1_Missense_Mutation_p.V125A|DDX47_uc001rax.2_Missense_Mutation_p.V125A|DDX47_uc001ray.2_Missense_Mutation_p.V125A|DDX47_uc010shn.1_3'UTR	NM_016355	NP_057439	Q9H0S4	DDX47_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 47	125	Helicase ATP-binding.					nucleolus|nucleolus	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding				0		Prostate(47;0.0526)		BRCA - Breast invasive adenocarcinoma(232;0.0354)		TCTGTAGCTGTGATTGTAGGT	0.358000													30	54					0	0	0.041601	0	0
ANP32D	23519	broad.mit.edu	37	12	48866684	48866684	+	Silent	SNP	C	T	T			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr12:48866684C>T	uc010slt.1	+	1	237	c.237C>T	c.(235-237)GGC>GGT	p.G79G		NM_012404	NP_036536	O95626	AN32D_HUMAN	acidic nuclear phosphoprotein 32D	79	LRR 3.									ovary(1)|central_nervous_system(1)	2						CCTCAGTGGGCCTAGAAGTAT	0.378000													34	62					0	0	0.050027	0	0
TDG	6996	broad.mit.edu	37	12	104380795	104380795	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr12:104380795C>T	uc001tkg.2	+	10	1383	c.1160C>T	c.(1159-1161)TCA>TTA	p.S387L	TDG_uc009zuk.2_Missense_Mutation_p.S383L|TDG_uc010swi.1_Missense_Mutation_p.S244L|TDG_uc010swj.1_Missense_Mutation_p.S175L	NM_003211	NP_003202	Q13569	TDG_HUMAN	thymine-DNA glycosylase	387					depyrimidination|mismatch repair	nucleoplasm	damaged DNA binding|mismatched DNA binding|protein binding|pyrimidine-specific mismatch base pair DNA N-glycosylase activity			ovary(3)|lung(3)	6				BRCA - Breast invasive adenocarcinoma(302;0.00114)		ATGACCCAGTCATTTACAGAC	0.413000								BER_DNA_glycosylases					6	149					0	0	0.021553	0	0
FBXO34	55030	broad.mit.edu	37	14	55818351	55818351	+	Missense_Mutation	SNP	C	G	G			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr14:55818351C>G	uc001xbu.2	+	2	1488	c.1243C>G	c.(1243-1245)CCT>GCT	p.P415A	FBXO34_uc001xbv.2_RNA|FBXO34_uc010aoo.2_Missense_Mutation_p.P415A	NM_017943	NP_060413	Q9NWN3	FBX34_HUMAN	F-box only protein 34	415										ovary(2)|lung(2)|skin(1)	5						CGTTGGGTTACCTTTTTCCTC	0.458000													46	132					0	0	0.048971	0	0
SFRS5	6430	broad.mit.edu	37	14	70238167	70238167	+	Missense_Mutation	SNP	A	G	G			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr14:70238167A>G	uc001xll.2	+	9	2259	c.808A>G	c.(808-810)AGT>GGT	p.S270G	SFRS5_uc001xlm.2_RNA|SFRS5_uc001xlo.2_Missense_Mutation_p.S270G|SFRS5_uc001xlp.2_Missense_Mutation_p.S270G|SFRS5_uc001xlq.2_Missense_Mutation_p.S267G	NM_006925	NP_008856	Q13243	SRSF5_HUMAN	splicing factor, arginine/serine-rich 5	270					mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|protein binding|RNA binding				0				all cancers(60;0.00144)|BRCA - Breast invasive adenocarcinoma(234;0.0132)|OV - Ovarian serous cystadenocarcinoma(108;0.0154)		ATCAGTTGACAGTGGCAATTA	0.428000													30	165					0	0	0.034045	0	0
DICER1	23405	broad.mit.edu	37	14	95562982	95562982	+	Missense_Mutation	SNP	C	A	A			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr14:95562982C>A	uc001ydw.2	-	24	4457	c.4275G>T	c.(4273-4275)GAG>GAT	p.E1425D	DICER1_uc010avh.1_Missense_Mutation_p.E323D|DICER1_uc001ydv.2_Missense_Mutation_p.E1415D|DICER1_uc001ydx.2_Missense_Mutation_p.E1425D|DICER1_uc001ydy.1_Missense_Mutation_p.E277D	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	1425					negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		ACATCAGGCTctcctcctcct	0.403000			Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				19	30					4.96729e-08	5.53318e-08	0.049695	1	0
LOC645752	645752	broad.mit.edu	37	15	78208916	78208916	+	Missense_Mutation	SNP	C	G	G	rs56290535	by1000genomes	TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr15:78208916C>G	uc010bky.2	-	14	1581	c.817G>C	c.(817-819)GAA>CAA	p.E273Q	LOC645752_uc010umq.1_5'Flank|uc002bcw.1_5'Flank|uc002bcx.1_5'Flank	NR_027024				SubName: Full=GOLGA6 protein; Flags: Fragment;												0						TCCAGATGTTCTCCTCCATCT	0.627000													3	93					0	0	0.004672	0	0
TELO2	9894	broad.mit.edu	37	16	1552985	1552985	+	Missense_Mutation	SNP	G	T	T			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr16:1552985G>T	uc002cly.2	+	15	2115	c.1824G>T	c.(1822-1824)CAG>CAT	p.Q608H		NM_016111	NP_057195	Q9Y4R8	TELO2_HUMAN	TEL2, telomere maintenance 2, homolog	608						chromosome, telomeric region|cytoplasm|membrane|nucleus	protein binding				0		Hepatocellular(780;0.219)				GCCTCCGGCAGCGCATGGACA	0.622000													16	118					4.75885e-15	5.51025e-15	0.033300	1	0
RRN3P1	730092	broad.mit.edu	37	16	21817457	21817457	+	Silent	SNP	G	A	A	rs150520281	by1000genomes	TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr16:21817457G>A	uc010vbl.1	-	7	603	c.106C>T	c.(106-108)CTG>TTG	p.L36L	uc002diq.3_Intron	NR_003370				SubName: Full=Putative uncharacterized protein ENSP00000219758;												0						CTTACATCCAGCTTGAGTAGT	0.254000													4	22					0	0	0.014758	0	0
CNOT1	23019	broad.mit.edu	37	16	58580300	58580300	+	Missense_Mutation	SNP	T	G	G			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr16:58580300T>G	uc002env.2	-	29	4224	c.3931A>C	c.(3931-3933)AAT>CAT	p.N1311H	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Missense_Mutation_p.N1306H|CNOT1_uc002enx.2_Missense_Mutation_p.N1311H|CNOT1_uc010vik.1_Missense_Mutation_p.N268H	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	1311					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		TCATCTAAATTCTTCAGGCGA	0.413000													37	99					0	0	0.069456	0	0
MLKL	197259	broad.mit.edu	37	16	74729257	74729257	+	Missense_Mutation	SNP	C	G	G			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr16:74729257C>G	uc002fdb.2	-	2	840	c.399G>C	c.(397-399)TGG>TGC	p.W133C	MLKL_uc002fdc.2_Missense_Mutation_p.W133C	NM_152649	NP_689862	Q8NB16	MLKL_HUMAN	mixed lineage kinase domain-like isoform 1	133							ATP binding|protein binding|protein kinase activity			stomach(2)	2						CTTCCTGTGCCCAGGACGCTC	0.542000													30	141					0	0	0.050027	0	0
ZNF778	197320	broad.mit.edu	37	16	89288533	89288533	+	Missense_Mutation	SNP	A	T	T			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr16:89288533A>T	uc002fmv.2	+	3	398	c.59A>T	c.(58-60)CAT>CTT	p.H20L	ZNF778_uc010vpf.1_RNA|ZNF778_uc002fmw.1_Intron|ZNF778_uc010vpg.1_5'UTR	NM_182531	NP_872337	Q96MU6	ZN778_HUMAN	zinc finger protein 778	20					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(80;0.0269)		GTCTGCCTTCATGAAGAACAG	0.443000													3	85					0	0	0.009096	0	0
SERPINF1	5176	broad.mit.edu	37	17	1673260	1673260	+	Silent	SNP	C	A	A			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr17:1673260C>A	uc002ftl.2	+	3	356	c.199C>A	c.(199-201)CGG>AGG	p.R67R	SERPINF1_uc010cjw.2_Intron	NM_002615	NP_002606	P36955	PEDF_HUMAN	serine (or cysteine) proteinase inhibitor, clade	67					cell proliferation|negative regulation of angiogenesis|positive regulation of neurogenesis|regulation of proteolysis	extracellular space|melanosome	serine-type endopeptidase inhibitor activity			ovary(1)	1						TGACCTGTACCGGGTGCGATC	0.632000													5	157					3.59834e-05	3.86163e-05	0.021553	1	0
SLC13A5	284111	broad.mit.edu	37	17	6597517	6597517	+	Splice_Site	SNP	C	G	G	rs113208940		TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr17:6597517C>G	uc002gdj.2	-	8	1144	c.1056_splice	c.e8-1	p.K352_splice	SLC13A5_uc010vtf.1_Splice_Site_p.K352_splice|SLC13A5_uc010clq.2_Splice_Site_p.K309_splice|SLC13A5_uc002gdk.2_Splice_Site_p.K335_splice	NM_177550	NP_808218	Q86YT5	S13A5_HUMAN	solute carrier family 13, member 5 isoform a							integral to membrane	citrate transmembrane transporter activity				0						GGAGACATACCTAGGTGGGGA	0.502000													15	42					0	0	0.024245	0	0
GAS7	8522	broad.mit.edu	37	17	9846496	9846496	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr17:9846496G>A	uc002gmg.1	-	7	834	c.673C>T	c.(673-675)CAG>TAG	p.Q225*	GAS7_uc010vvc.1_Nonsense_Mutation_p.Q39*|GAS7_uc002gmh.1_Nonsense_Mutation_p.Q85*|GAS7_uc010vvd.1_Nonsense_Mutation_p.Q177*|GAS7_uc002gmi.2_Nonsense_Mutation_p.Q161*|GAS7_uc002gmj.1_Nonsense_Mutation_p.Q165*|GAS7_uc010coh.1_Nonsense_Mutation_p.Q165*	NM_201433	NP_958839	O60861	GAS7_HUMAN	growth arrest-specific 7 isoform c	225	FCH.				cell cycle arrest	cytoplasm	sequence-specific DNA binding transcription factor activity			lung(1)|pancreas(1)	2						AGCTGTTTCTGGAGCAGTAGT	0.552000			T	MLL	AML*								13	264					0	0	0.024245	0	0
MYO1D	4642	broad.mit.edu	37	17	30932193	30932193	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr17:30932193C>T	uc002hho.1	-	21	2788	c.2776G>A	c.(2776-2778)GAC>AAC	p.D926N	MYO1D_uc002hhp.1_Missense_Mutation_p.D926N	NM_015194	NP_056009	O94832	MYO1D_HUMAN	myosin ID	926						myosin complex	actin binding|ATP binding|calmodulin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3			BRCA - Breast invasive adenocarcinoma(9;0.0362)			ACAATGAGGTCTTTGTTGTCT	0.423000													18	76					0	0	0.038395	0	0
UBTF	7343	broad.mit.edu	37	17	42289818	42289818	+	Missense_Mutation	SNP	G	C	C			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr17:42289818G>C	uc002igb.2	-	7	732	c.665C>G	c.(664-666)ACT>AGT	p.T222S	UBTF_uc002igc.2_Intron|UBTF_uc010czs.2_Missense_Mutation_p.T222S|UBTF_uc002igd.2_Intron|UBTF_uc010czt.2_Missense_Mutation_p.T222S|UBTF_uc002ige.2_Intron	NM_014233	NP_055048	P17480	UBF1_HUMAN	upstream binding transcription factor, RNA	222	HMG box 2.				positive regulation of transcription from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm	DNA binding|protein binding				0		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.114)		CTCCTTCGTAGTGGCCTGCAA	0.637000													39	118					0	0	0.086207	0	0
MRPL10	124995	broad.mit.edu	37	17	45901623	45901623	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr17:45901623G>A	uc002ilz.2	-	5	760	c.734C>T	c.(733-735)TCT>TTT	p.S245F	OSBPL7_uc002ilx.1_5'Flank|MRPL10_uc010wky.1_Missense_Mutation_p.S206F|MRPL10_uc002ily.2_Missense_Mutation_p.S255F	NM_145255	NP_660298	Q7Z7H8	RM10_HUMAN	mitochondrial ribosomal protein L10 precursor	245					ribosome biogenesis|translation	mitochondrial large ribosomal subunit	structural constituent of ribosome			ovary(1)	1						CGACATGACAGAATCCTTCTC	0.577000													72	78					0	0	0.048971	0	0
GGA3	23163	broad.mit.edu	37	17	73237524	73237524	+	Silent	SNP	G	T	T			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr17:73237524G>T	uc002jni.1	-	10	912	c.903C>A	c.(901-903)GTC>GTA	p.V301V	GGA3_uc002jnj.1_Silent_p.V268V|GGA3_uc010wrw.1_Silent_p.V179V|GGA3_uc002jnk.1_Silent_p.V229V|GGA3_uc010wrx.1_Silent_p.V179V|GGA3_uc010wry.1_Silent_p.V229V	NM_138619	NP_619525	Q9NZ52	GGA3_HUMAN	ADP-ribosylation factor binding protein 3	301	Binds to ARF1 (in long isoform).|Unstructured hinge.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			ovary(1)|breast(1)	2			all cancers(21;2.39e-06)|Epithelial(20;2.38e-05)			CGCCATTGATGACCTGCCCTT	0.547000													4	145					0.00909568	0.00930721	0.009096	1	0
SHC2	25759	broad.mit.edu	37	19	422226	422226	+	Missense_Mutation	SNP	T	C	C			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr19:422226T>C	uc002loq.3	-	11	1540	c.1540A>G	c.(1540-1542)ACC>GCC	p.T514A	SHC2_uc002lop.3_Missense_Mutation_p.T255A	NM_012435	NP_036567	P98077	SHC2_HUMAN	SHC (Src homology 2 domain containing)	514	SH2.				insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol					0		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCGGGGTTGGTGACGCTGTCT	0.677000													8	16					0	0	0.038147	0	0
MADCAM1	8174	broad.mit.edu	37	19	501762	501762	+	Missense_Mutation	SNP	A	C	C			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr19:501762A>C	uc002los.2	+	4	771	c.761A>C	c.(760-762)CAG>CCG	p.Q254P	MADCAM1_uc002lot.2_Intron|MADCAM1_uc010drq.2_Intron	NM_130760	NP_570116	Q13477	MADCA_HUMAN	mucosal vascular addressin cell adhesion	254	Mucin-like.|Extracellular (Potential).|5.5 X 8 AA tandem repeats of [PS]-P-D-T- T-S-[QP]-E.|4.			Q -> P (in Ref. 1; AAC13661).	cell adhesion|immune response|regulation of immune response|signal transduction	integral to membrane|membrane fraction|plasma membrane					0		all_cancers(10;4.25e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCACCTCCCAGGAGCCTCCC	0.721000													4	9					0	0	0.014758	0	0
MUC16	94025	broad.mit.edu	37	19	9046479	9046479	+	Missense_Mutation	SNP	C	G	G			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr19:9046479C>G	uc002mkp.2	-	5	35356	c.35152G>C	c.(35152-35154)GTA>CTA	p.V11718L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11720	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTGGCCATTACAGGTGTGGCA	0.502000													37	96					0	0	0.092188	0	0
MUC16	94025	broad.mit.edu	37	19	9085838	9085838	+	Nonsense_Mutation	SNP	C	A	A			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr19:9085838C>A	uc002mkp.2	-	1	6181	c.5977G>T	c.(5977-5979)GAA>TAA	p.E1993*		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1993	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAAACTTTTTCTGAAGAAACT	0.473000													6	94					8.12818e-05	8.61783e-05	0.029380	1	0
ZNF44	51710	broad.mit.edu	37	19	12384693	12384693	+	Missense_Mutation	SNP	G	C	C			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr19:12384693G>C	uc010xmj.1	-	5	726	c.521C>G	c.(520-522)ACT>AGT	p.T174S	ZNF44_uc002mtl.2_Intron|ZNF44_uc010dyr.1_Intron|ZNF44_uc010xmi.1_RNA|ZNF44_uc002mtn.3_RNA|ZNF44_uc010dys.2_Missense_Mutation_p.T126S	NM_001164276	NP_001157748	P15621	ZNF44_HUMAN	zinc finger protein 44 isoform 1	174					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1		Renal(1328;0.157)		GBM - Glioblastoma multiforme(1328;0.0164)|Lung(535;0.179)		TTTGTGTCCAGTATCAACTCT	0.438000													40	107					0	0	0.039052	0	0
ZNF208	7757	broad.mit.edu	37	19	22157487	22157487	+	Missense_Mutation	SNP	A	T	T			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr19:22157487A>T	uc002nqp.2	-	4	498	c.349T>A	c.(349-351)TAT>AAT	p.Y117N	ZNF208_uc002nqo.1_Intron|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				ACATTGGTATAACCAATTTTT	0.353000													6	166					0	0	0.029380	0	0
ZNF544	27300	broad.mit.edu	37	19	58774085	58774085	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr19:58774085G>A	uc010euo.2	+	7	2587	c.2113G>A	c.(2113-2115)GTG>ATG	p.V705M	ZNF544_uc010yhw.1_RNA|ZNF544_uc010yhx.1_Missense_Mutation_p.V677M|ZNF544_uc010yhy.1_Missense_Mutation_p.V677M|ZNF544_uc002qrt.3_Missense_Mutation_p.V563M|ZNF544_uc002qru.3_Missense_Mutation_p.V563M|uc002qrx.1_Intron	NM_014480	NP_055295	Q6NX49	ZN544_HUMAN	zinc finger protein 544	705	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		all_cancers(17;4.17e-12)|all_epithelial(17;1.25e-08)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.17)|GBM - Glioblastoma multiforme(193;0.018)		TCAACTTGTAGTGCATCGGCG	0.488000													71	192					0	0	0.048971	0	0
NT5C1B	93034	broad.mit.edu	37	2	18767651	18767651	+	Missense_Mutation	SNP	G	C	C			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr2:18767651G>C	uc002rcz.2	-	4	411	c.307C>G	c.(307-309)CAA>GAA	p.Q103E	NT5C1B_uc002rcy.2_Missense_Mutation_p.Q103E|NT5C1B_uc010exr.2_Missense_Mutation_p.Q43E|NT5C1B_uc010yju.1_Missense_Mutation_p.Q43E|NT5C1B_uc002rda.2_Missense_Mutation_p.Q43E|NT5C1B_uc010yjv.1_Missense_Mutation_p.Q120E|NT5C1B_uc010yjw.1_Missense_Mutation_p.Q86E|NT5C1B_uc010exs.2_Missense_Mutation_p.Q103E|NT5C1B_uc002rdb.1_5'Flank	NM_001002006	NP_001002006	Q96P26	5NT1B_HUMAN	5' nucleotidase, cytosolic IB isoform 1	103	Ser-rich.				purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			skin(2)|ovary(1)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				GATGATTCTTGTGATCCCTGT	0.488000													10	71					0	0	0.058154	0	0
CPO	130749	broad.mit.edu	37	2	207827299	207827299	+	Silent	SNP	C	T	T			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr2:207827299C>T	uc002vby.2	+	7	784	c.738C>T	c.(736-738)TAC>TAT	p.Y246Y		NM_173077	NP_775100	Q8IVL8	CBPO_HUMAN	carboxypeptidase O precursor	246					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			large_intestine(1)|ovary(1)	2				LUSC - Lung squamous cell carcinoma(261;0.0744)|Epithelial(149;0.0807)|Lung(261;0.142)		TCACACCTTACGGCTACACCA	0.448000													12	195					0	0	0.020292	0	0
JAG1	182	broad.mit.edu	37	20	10625851	10625851	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr20:10625851C>T	uc002wnw.2	-	17	2683	c.2167G>A	c.(2167-2169)GAG>AAG	p.E723K	JAG1_uc010gcd.1_Missense_Mutation_p.E281K	NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	723	Extracellular (Potential).|EGF-like 13.				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity	p.E723fs*6(1)		lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9						GCATCCCCCTCATCATAGCAG	0.547000									Alagille_Syndrome				35	76					0	0	0.080422	0	0
SON	6651	broad.mit.edu	37	21	34918555	34918555	+	Missense_Mutation	SNP	T	G	G			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr21:34918555T>G	uc002yse.1	+	2	163	c.114T>G	c.(112-114)AAT>AAG	p.N38K	SON_uc002ysb.1_Missense_Mutation_p.N38K|SON_uc002ysc.2_Missense_Mutation_p.N38K|SON_uc002ysd.2_5'UTR|SON_uc002ysf.1_Missense_Mutation_p.N38K	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	38					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						GTGAAACAAATACACCCATTG	0.393000													20	38					0	0	0.055883	0	0
SON	6651	broad.mit.edu	37	21	34922861	34922861	+	Missense_Mutation	SNP	T	G	G			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr21:34922861T>G	uc002yse.1	+	3	1373	c.1324T>G	c.(1324-1326)TCT>GCT	p.S442A	SON_uc002ysb.1_Missense_Mutation_p.S442A|SON_uc002ysc.2_Missense_Mutation_p.S442A|SON_uc002ysd.2_5'UTR|SON_uc002ysf.1_Intron|SON_uc002ysg.2_5'Flank	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	442					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						GCCAGGGCCCTCTGTGACACC	0.632000													22	54					0	0	0.062417	0	0
ERG	2078	broad.mit.edu	37	21	39775557	39775557	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr21:39775557C>T	uc010gnw.2	-	6	779	c.484G>A	c.(484-486)GTC>ATC	p.V162I	ERG_uc002yxa.2_Missense_Mutation_p.V155I|ERG_uc011aek.1_Missense_Mutation_p.V63I|ERG_uc010gnv.2_Missense_Mutation_p.V63I|ERG_uc010gnx.2_Missense_Mutation_p.V162I|ERG_uc011ael.1_Missense_Mutation_p.V162I|ERG_uc002yxb.2_Missense_Mutation_p.V162I|ERG_uc011aem.1_Intron|ERG_uc002yxc.3_Missense_Mutation_p.V162I|ERG_uc010gny.1_RNA	NM_001136155	NP_001129627	P11308	ERG_HUMAN	ets-related isoform 4	162	PNT.				cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		TMPRSS2/ERG(2499)|FUS/ERG(163)|EWSR1/ERG(162)	prostate(2499)|bone(167)|haematopoietic_and_lymphoid_tissue(153)|soft_tissue(5)|lung(2)|skin(1)|ovary(1)	2828		Prostate(19;3.6e-06)				AAGATGTTGACGTCTGGAAGG	0.527000													8	80					0	0	0.038147	0	0
UBE2L3	7332	broad.mit.edu	37	22	21975858	21975858	+	Missense_Mutation	SNP	G	C	C			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr22:21975858G>C	uc002zva.1	+	4	442	c.365G>C	c.(364-366)CGG>CCG	p.R122P	UBE2L3_uc011aig.1_Missense_Mutation_p.R90P|UBE2L3_uc002zuz.1_3'UTR|UBE2L3_uc010gti.1_RNA	NM_003347	NP_003338	P68036	UB2L3_HUMAN	ubiquitin-conjugating enzyme E2L 3	122					cell proliferation|cellular response to glucocorticoid stimulus|protein K11-linked ubiquitination|regulation of S phase of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	ATP binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity				0	Colorectal(54;0.105)					CACCCGCTTCGGGCTGACCTA	0.478000													16	27					0	0	0.033300	0	0
LOC96610	96610	broad.mit.edu	37	22	22663086	22663086	+	RNA	SNP	T	G	G	rs1054157	by1000genomes	TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr22:22663086T>G	uc011aim.1	+	29		c.1859T>G			LOC96610_uc011aiq.1_RNA|LOC96610_uc011aip.1_RNA|LOC96610_uc010gto.2_RNA					Parts of antibodies, mostly variable regions.												0						AGCTGCCACATAAGTTGTCCT	0.299000													5	35					0	0	0.021553	0	0
LIMK2	3985	broad.mit.edu	37	22	31667152	31667152	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr22:31667152C>T	uc003akh.2	+	12	1493	c.1348C>T	c.(1348-1350)CGG>TGG	p.R450W	LIMK2_uc003akg.2_Missense_Mutation_p.R367W|LIMK2_uc003aki.2_Missense_Mutation_p.R204W|LIMK2_uc003akj.2_Missense_Mutation_p.R429W|LIMK2_uc003akk.2_Missense_Mutation_p.R429W|LIMK2_uc011aln.1_Missense_Mutation_p.R367W	NM_005569	NP_005560	P53671	LIMK2_HUMAN	LIM domain kinase 2 isoform 2a	450	Protein kinase.					mitochondrion|nucleus	ATP binding|protein serine/threonine kinase activity|zinc ion binding			ovary(2)	2						CATCATCCACCGGGATCTGAA	0.537000													4	137					0	0	0.014758	0	0
VHL	7428	broad.mit.edu	37	3	10191506	10191506	+	Missense_Mutation	SNP	C	G	G	rs5030820		TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr3:10191506C>G	uc003bvc.2	+	3	712	c.499C>G	c.(499-501)CGG>GGG	p.R167G	VHL_uc003bvd.2_Missense_Mutation_p.R126G	NM_000551	NP_000542	P40337	VHL_HUMAN	von Hippel-Lindau tumor suppressor isoform 1	167			R -> G (in VHLD; type I-II).		anti-apoptosis|cell morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell differentiation|positive regulation of transcription, DNA-dependent|protein stabilization|protein ubiquitination|proteolysis	cytosol|endoplasmic reticulum|membrane|mitochondrion|nucleus	protein binding|transcription factor binding	p.R167W(6)|p.R167Q(4)|p.R167fs*3(2)|p.R167G(1)|p.R167fs*1(1)|p.V166fs*6(1)|p.R167fs*6(1)		kidney(1273)|soft_tissue(24)|adrenal_gland(15)|large_intestine(13)|pancreas(5)|endometrium(4)|thyroid(3)|upper_aerodigestive_tract(3)|central_nervous_system(2)|lung(2)|pleura(1)|paratesticular_tissues(1)	1346				Kidney(1;0.000404)|KIRC - Kidney renal clear cell carcinoma(1;0.000569)		CCAGGTTGTCCGGAGCCTAGT	0.512000		1	D|Mis|N|F|S		renal|hemangioma|pheochromocytoma	renal|hemangioma|pheochromocytoma			von_Hippel-Lindau_disease|Chuvash_Polycythemia_|Pheochromocytoma_(Adrenal)_Familial				18	27					0	0	0.062417	0	0
BAP1	8314	broad.mit.edu	37	3	52443866	52443866	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr3:52443866C>T	uc003ddx.2	-	1	144	c.29G>A	c.(28-30)AGC>AAC	p.S10N	PHF7_uc003ddy.2_5'Flank|PHF7_uc003ddz.2_5'Flank	NM_004656	NP_004647	Q92560	BAP1_HUMAN	BRCA1 associated protein-1	10					monoubiquitinated histone H2A deubiquitination|negative regulation of cell proliferation|protein K48-linked deubiquitination|regulation of cell cycle|regulation of cell growth|ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|PR-DUB complex	chromatin binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			pleura(32)|eye(28)|lung(2)|ovary(2)|breast(1)	65				BRCA - Breast invasive adenocarcinoma(193;1.72e-05)|Kidney(197;0.0018)|KIRC - Kidney renal clear cell carcinoma(197;0.00203)|OV - Ovarian serous cystadenocarcinoma(275;0.0277)		ACCTGGGTCGCTCTCCAGCTC	0.746000			N|Mis|F|S|O		uveal melanoma|breast|NSCLC								20	17					0	0	0.062417	0	0
APBB2	323	broad.mit.edu	37	4	41015603	41015603	+	Missense_Mutation	SNP	T	A	A			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr4:41015603T>A	uc003gvl.2	-	6	1462	c.832A>T	c.(832-834)ACA>TCA	p.T278S	APBB2_uc003gvm.2_Missense_Mutation_p.T278S|APBB2_uc003gvn.2_Missense_Mutation_p.T278S|APBB2_uc011byt.1_Missense_Mutation_p.T261S	NM_173075	NP_775098	Q92870	APBB2_HUMAN	amyloid beta A4 precursor protein-binding,	278					cell cycle arrest|intracellular signal transduction|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|regulation of transcription, DNA-dependent	growth cone|lamellipodium|membrane|nucleus|synapse	beta-amyloid binding|transcription factor binding			ovary(2)|large_intestine(1)	3						GGGGTACCTGTTTCATCCGGG	0.507000													83	210					0	0	0.048971	0	0
TMPRSS11A	339967	broad.mit.edu	37	4	68777129	68777129	+	Silent	SNP	C	T	T			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr4:68777129C>T	uc003hdr.1	-	10	1318	c.1197G>A	c.(1195-1197)AAG>AAA	p.K399K	LOC550112_uc003hdl.3_Intron|TMPRSS11A_uc003hds.1_Silent_p.K396K	NM_182606	NP_872412	Q6ZMR5	TM11A_HUMAN	transmembrane protease, serine 11A isoform 1	399	Peptidase S1.|Extracellular (Potential).				cell cycle|proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			skin(1)	1						CAGGCTTGTCCTTTTGACCAC	0.403000													7	148					0	0	0.038147	0	0
ALPK1	80216	broad.mit.edu	37	4	113333046	113333046	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr4:113333046G>A	uc003iap.3	+	5	619	c.340G>A	c.(340-342)GTG>ATG	p.V114M	ALPK1_uc011cfw.1_RNA|ALPK1_uc003ian.3_Missense_Mutation_p.V114M|ALPK1_uc011cfx.1_Missense_Mutation_p.V36M|ALPK1_uc003iao.3_RNA|ALPK1_uc003iaq.2_Missense_Mutation_p.V58M|ALPK1_uc010imo.2_Translation_Start_Site|ALPK1_uc003iar.2_Missense_Mutation_p.V84M	NM_025144	NP_079420	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	114							ATP binding|protein serine/threonine kinase activity			ovary(5)	5		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		TGTGTTCTTGGTGGACCGGTT	0.622000													7	29					0	0	0.029380	0	0
KIAA1109	84162	broad.mit.edu	37	4	123128292	123128292	+	Missense_Mutation	SNP	G	C	C			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr4:123128292G>C	uc003ieh.2	+	14	1571	c.1526G>C	c.(1525-1527)AGT>ACT	p.S509T	KIAA1109_uc003iei.1_Missense_Mutation_p.S263T|KIAA1109_uc010ins.1_5'UTR|KIAA1109_uc003iej.1_5'Flank	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	509					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TCTAGTGACAGTCCTCCAGAC	0.313000													55	170					0	0	0.048971	0	0
MGC42105	167359	broad.mit.edu	37	5	43280172	43280172	+	Missense_Mutation	SNP	A	G	G			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr5:43280172A>G	uc003jno.2	+	4	1533	c.652A>G	c.(652-654)AGC>GGC	p.S218G		NM_153361	NP_699192	Q8IY84	NIM1_HUMAN	serine/threonine-protein kinase NIM1	218	Protein kinase.						ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|stomach(1)|large_intestine(1)|breast(1)	9						TTTTGGATTCAGCACAGTAAG	0.433000													32	75					0	0	0.054565	0	0
HTR1A	3350	broad.mit.edu	37	5	63257393	63257393	+	Silent	SNP	G	A	A			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr5:63257393G>A	uc011cqt.1	-	1	154	c.154C>T	c.(154-156)CTG>TTG	p.L52L		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	52	Helical; Name=1; (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	GCATTGCCCAGCACCGCGCAG	0.592000													3	73					0	0	0.004672	0	0
BDP1	55814	broad.mit.edu	37	5	70800508	70800508	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr5:70800508C>T	uc003kbp.1	+	16	2565	c.2302C>T	c.(2302-2304)CAG>TAG	p.Q768*	BDP1_uc003kbn.1_Nonsense_Mutation_p.Q768*|BDP1_uc003kbo.2_Nonsense_Mutation_p.Q768*	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	768					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		TGTCATATTACAGCCTGAGAA	0.328000													36	85					0	0	0.074837	0	0
LOC100133050	100133050	broad.mit.edu	37	5	99715528	99715528	+	RNA	SNP	C	T	T			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr5:99715528C>T	uc011cuw.1	-	4		c.382G>A				NR_027503				Homo sapiens glucuronidase, beta pseudogene (LOC100133050), non-coding RNA.												0						AGCGGACAGTCGAAGCCCTTC	0.607000													3	17					0	0	0.004672	0	0
PECI	10455	broad.mit.edu	37	6	4128067	4128067	+	Splice_Site	SNP	T	A	A			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr6:4128067T>A	uc003mwf.2	-	5	539	c.502_splice	c.e5-1	p.M168_splice	C6orf201_uc003mwa.3_Intron|C6orf201_uc003mvz.3_Intron|C6orf201_uc003mwb.3_Intron|PECI_uc003mwc.2_Splice_Site_p.M1_splice|PECI_uc003mwd.2_Splice_Site_p.M138_splice|PECI_uc003mwe.2_Splice_Site_p.M15_splice|PECI_uc010jnr.1_Splice_Site	NM_206836	NP_996667	O75521	ECI2_HUMAN	peroxisomal D3,D2-enoyl-CoA isomerase isoform 2						fatty acid metabolic process	mitochondrion|peroxisomal matrix	dodecenoyl-CoA delta-isomerase activity|fatty-acyl-CoA binding				0	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				ATGATACATCTGTGTAATGGG	0.398000													43	119					0	0	0.048971	0	0
SCGN	10590	broad.mit.edu	37	6	25701539	25701539	+	Silent	SNP	T	C	C			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr6:25701539T>C	uc003nfb.2	+	11	1010	c.807T>C	c.(805-807)TGT>TGC	p.C269C	SCGN_uc010jpz.2_Silent_p.C160C	NM_006998	NP_008929	O76038	SEGN_HUMAN	secretagogin precursor	269	EF-hand 6.					extracellular region|transport vesicle membrane	calcium ion binding			ovary(2)|pancreas(1)	3						TGGCTTTGTGTCTTGGGCTGA	0.463000													49	111					0	0	0.048971	0	0
SKIV2L	6499	broad.mit.edu	37	6	31937328	31937328	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr6:31937328G>A	uc003nyn.1	+	28	3966	c.3577G>A	c.(3577-3579)GAG>AAG	p.E1193K	SKIV2L_uc011dou.1_Missense_Mutation_p.E1035K|SKIV2L_uc011dov.1_Missense_Mutation_p.E1000K|STK19_uc003nyt.2_5'Flank|STK19_uc011dow.1_5'Flank|STK19_uc011dox.1_5'Flank|STK19_uc003nyv.2_5'Flank|STK19_uc003nyw.2_5'Flank|STK19_uc010jtn.1_5'Flank	NM_006929	NP_008860	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like homolog	1193						nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						AGGGACCCCTGAGGGCCTGGT	0.662000													35	101					0	0	0.069456	0	0
CLK2P	1197	broad.mit.edu	37	7	23625147	23625147	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr7:23625147C>T	uc003swk.2	-	1	1000	c.350G>A	c.(349-351)CGC>CAC	p.R117H		NR_002711				SubName: Full=cDNA FLJ61616, highly similar to Dual specificity protein kinase CLK2 (EC 2.7.12.1); SubName: Full=CDC-like kinase 2, isoform CRA_c; SubName: Full=Putative uncharacterized protein CLK2;												0						TCGGTAATGGCGAGTGGAGAC	0.527000													4	73					0	0	0.009096	0	0
C7orf51	222950	broad.mit.edu	37	7	100087003	100087003	+	Silent	SNP	C	T	T			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr7:100087003C>T	uc003uvd.1	+	4	1818	c.1659C>T	c.(1657-1659)GCC>GCT	p.A553A	C7orf51_uc003uve.1_Silent_p.A335A	NM_173564	NP_775835	Q6ZVC0	CG051_HUMAN	hypothetical protein FLJ37538	553										skin(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CCTACCCAGCCACAGCAGCTG	0.682000													17	47					0	0	0.033300	0	0
LAMB1	3912	broad.mit.edu	37	7	107580801	107580801	+	Missense_Mutation	SNP	A	G	G			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr7:107580801A>G	uc003vew.2	-	25	3729	c.3394T>C	c.(3394-3396)TGT>CGT	p.C1132R	LAMB1_uc003vev.2_Missense_Mutation_p.C1156R	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	1132	Laminin EGF-like 13.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCACAGTCACAGGCTAGAAGG	0.502000													3	53					0	0	0.004672	0	0
RPL23AP53	644128	broad.mit.edu	37	8	163401	163401	+	RNA	SNP	G	C	C			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr8:163401G>C	uc010lra.2	-	4		c.732C>G			RPL23AP53_uc003woq.3_RNA|RPL23AP53_uc010lrb.2_RNA	NR_003572				Homo sapiens cDNA FLJ45055 fis, clone BRAWH3022900.												0						TCTGGTGCTTGTTGGCTTTAA	0.463000													3	74					0	0	0.009096	0	0
KIAA1967	57805	broad.mit.edu	37	8	22473664	22473664	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr8:22473664C>T	uc003xch.2	+	14	1885	c.1748C>T	c.(1747-1749)GCC>GTC	p.A583V	KIAA1967_uc003xci.2_Missense_Mutation_p.A583V|KIAA1967_uc003xcj.1_Missense_Mutation_p.A252V	NM_199205	NP_954675	Q8N163	K1967_HUMAN	p30 DBC protein	583					apoptosis|positive regulation of apoptosis	mitochondrial matrix|nucleus	enzyme binding|enzyme inhibitor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00593)|Colorectal(74;0.0157)|COAD - Colon adenocarcinoma(73;0.064)		AAGGAAGAAGCCACCAAGGAG	0.552000													32	80					0	0	0.054565	0	0
KCTD9	54793	broad.mit.edu	37	8	25293942	25293942	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr8:25293942C>T	uc003xeo.2	-	7	717	c.559G>A	c.(559-561)GCA>ACA	p.A187T	PPP2R2A_uc003xek.2_Intron|KCTD9_uc011lad.1_5'Flank	NM_017634	NP_060104	Q7L273	KCTD9_HUMAN	potassium channel tetramerisation domain	187						voltage-gated potassium channel complex	voltage-gated potassium channel activity				0		all_cancers(63;0.0164)|Ovarian(32;0.000878)|all_epithelial(46;0.00542)|Breast(100;0.0164)|Hepatocellular(4;0.114)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0219)|Epithelial(17;2.39e-12)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0438)		ACCTTTATTGCCACTTCTAGG	0.323000													3	65					0	0	0.009096	0	0
TEX15	56154	broad.mit.edu	37	8	30704070	30704070	+	Missense_Mutation	SNP	T	C	C			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr8:30704070T>C	uc003xil.2	-	1	2464	c.2464A>G	c.(2464-2466)ATT>GTT	p.I822V		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	822										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		TGGGAATAAATGTCAAATCCT	0.373000													10	80					0	0	0.058154	0	0
ADAM2	2515	broad.mit.edu	37	8	39604144	39604144	+	Missense_Mutation	SNP	C	T	T	rs111543786	byFrequency	TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr8:39604144C>T	uc003xnj.2	-	19	2096	c.2021G>A	c.(2020-2022)CGC>CAC	p.R674H	ADAM2_uc003xnk.2_Missense_Mutation_p.R655H|ADAM2_uc011lck.1_Missense_Mutation_p.R611H|ADAM2_uc003xnl.2_Missense_Mutation_p.R518H	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein	674	Extracellular (Potential).				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		CTCAATGTAGCGCCTTTCTAG	0.299000													20	90					0	0	0.049695	0	0
FAM75A3	727830	broad.mit.edu	37	9	40705657	40705657	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr9:40705657C>T	uc010mmj.2	+	4	3343	c.3314C>T	c.(3313-3315)CCC>CTC	p.P1105L		NM_001083124	NP_001076593	Q5VYP0	F75A3_HUMAN	hypothetical protein LOC727830	1105						integral to membrane				ovary(2)|skin(1)	3				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		CCAATGTTTCCCCCTATTCAC	0.478000													149	124					0	0	0.048971	0	0
RORB	6096	broad.mit.edu	37	9	77286722	77286722	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr9:77286722G>A	uc004aji.2	+	9	1211	c.1162G>A	c.(1162-1164)GAA>AAA	p.E388K	RORB_uc004ajh.2_Missense_Mutation_p.E377K	NM_006914	NP_008845	Q92753	RORB_HUMAN	RAR-related orphan receptor B	388	Ligand-binding (Potential).				eye photoreceptor cell development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding	p.E377*(1)		ovary(2)|lung(1)|skin(1)	4						CTGGCTTATAGAACCAAGGAA	0.428000													27	53					0	0	0.037714	0	0
CDK5RAP2	55755	broad.mit.edu	37	9	123313163	123313163	+	Missense_Mutation	SNP	C	A	A			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr9:123313163C>A	uc004bkf.2	-	4	394	c.213G>T	c.(211-213)AAG>AAT	p.K71N	CDK5RAP2_uc004bkg.2_Missense_Mutation_p.K71N|CDK5RAP2_uc011lxw.1_5'UTR|CDK5RAP2_uc011lxx.1_RNA|CDK5RAP2_uc011lxy.1_RNA|CDK5RAP2_uc011lxz.1_5'UTR|CDK5RAP2_uc011lya.1_5'UTR|CDK5RAP2_uc004bkh.1_Missense_Mutation_p.K71N	NM_018249	NP_060719	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	71					brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			ovary(2)|lung(1)|skin(1)	4						AGTTTTCTTTCTTCAATTCAG	0.383000													5	120					1.23904e-05	1.36294e-05	0.014758	1	0
TUBBP5	643224	broad.mit.edu	37	9	141070969	141070969	+	Silent	SNP	A	G	G			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr9:141070969A>G	uc004com.2	+	4	633	c.372A>G	c.(370-372)GCA>GCG	p.A124A	TUBBP5_uc010ncq.2_3'UTR					RecName: Full=Putative tubulin beta-4q chain;												0						TAGAAAACGCAGATGAGACCT	0.517000													4	41					0	0	0.014758	0	0
UTP14A	10813	broad.mit.edu	37	X	129045744	129045744	+	Silent	SNP	C	T	T			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chrX:129045744C>T	uc004euz.2	+	6	412	c.384C>T	c.(382-384)ATC>ATT	p.I128I	UTP14A_uc011mup.1_Intron|UTP14A_uc011muq.1_Silent_p.I74I	NM_006649	NP_006640	Q9BVJ6	UT14A_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein,	128					rRNA processing	nucleolus|small-subunit processome	protein binding			ovary(2)	2						TGCTTCAGATCCACAGAGAAG	0.473000													96	55					0	0	0.048971	0	0
RCAN3	11123	broad.mit.edu	37	1	24840967	24840967	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr1:24840967delT	uc001bjj.2	+	2	418	c.105delT	c.(103-105)GATfs	p.D35fs	RCAN3_uc009vrd.2_Frame_Shift_Del_p.D35fs|RCAN3_uc009vre.2_Frame_Shift_Del_p.D35fs|RCAN3_uc009vrf.2_Frame_Shift_Del_p.D35fs|RCAN3_uc009vrg.2_Frame_Shift_Del_p.D35fs	NM_013441	NP_038469	Q9UKA8	RCAN3_HUMAN	Down syndrome critical region gene 1-like 2	35					anatomical structure morphogenesis|calcium-mediated signaling		nucleotide binding|RNA binding|troponin I binding				0		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00125)|Ovarian(437;0.00473)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0427)|OV - Ovarian serous cystadenocarcinoma(117;1.13e-24)|Colorectal(126;6.09e-08)|COAD - Colon adenocarcinoma(152;3.33e-06)|GBM - Glioblastoma multiforme(114;0.000923)|BRCA - Breast invasive adenocarcinoma(304;0.0018)|KIRC - Kidney renal clear cell carcinoma(1967;0.00359)|STAD - Stomach adenocarcinoma(196;0.00493)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.14)		ATGAAGATGATTTGGATGAGA	0.433													21	82	---	---	---	---					
MTCH2	23788	broad.mit.edu	37	11	47653227	47653227	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr11:47653227delG	uc010rho.1	-	6	595	c.406delC	c.(406-408)CTCfs	p.L136fs	MTCH2_uc001nge.2_Frame_Shift_Del_p.L9fs|MTCH2_uc010rhp.1_Intron	NM_014342	NP_055157	Q9Y6C9	MTCH2_HUMAN	mitochondrial carrier 2	136	Solcar 2.				transport	integral to membrane|mitochondrial inner membrane					0						TGTGTGATGAGGGTAGCAGCA	0.433													23	43	---	---	---	---					
CHD8	57680	broad.mit.edu	37	14	21862522	21862522	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr14:21862522delT	uc001was.1	-	31	4770	c.4676delA	c.(4675-4677)AAGfs	p.K1559fs	CHD8_uc001war.1_Frame_Shift_Del_p.K1455fs|SNORD9_uc001wat.1_5'Flank	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	1838					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		TTCATCTGTCTTTTTGTCTAG	0.498													24	59	---	---	---	---					
NFATC3	4775	broad.mit.edu	37	16	68200904	68200904	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr16:68200904delT	uc002evo.1	+	5	1970	c.1760delT	c.(1759-1761)ATAfs	p.I587fs	NFATC3_uc010vkl.1_Frame_Shift_Del_p.I108fs|NFATC3_uc010vkm.1_Frame_Shift_Del_p.I108fs|NFATC3_uc010vkn.1_Frame_Shift_Del_p.I108fs|NFATC3_uc010vko.1_Frame_Shift_Del_p.I108fs|NFATC3_uc010vkp.1_Frame_Shift_Del_p.I108fs|NFATC3_uc010vkq.1_Frame_Shift_Del_p.I108fs|NFATC3_uc002evl.2_Frame_Shift_Del_p.I108fs|NFATC3_uc002evk.2_Frame_Shift_Del_p.I587fs|NFATC3_uc002evm.1_Frame_Shift_Del_p.I587fs|NFATC3_uc002evn.1_Frame_Shift_Del_p.I587fs|NFATC3_uc010vkr.1_Frame_Shift_Del_p.I108fs|NFATC3_uc010vks.1_Frame_Shift_Del_p.I108fs|NFATC3_uc010vkt.1_Frame_Shift_Del_p.I108fs|NFATC3_uc010vku.1_Frame_Shift_Del_p.I108fs|NFATC3_uc010vkv.1_Frame_Shift_Del_p.I108fs|NFATC3_uc010vkw.1_Frame_Shift_Del_p.I108fs|NFATC3_uc010vkx.1_Frame_Shift_Del_p.I108fs|NFATC3_uc010vky.1_Frame_Shift_Del_p.I108fs|NFATC3_uc010vkz.1_Frame_Shift_Del_p.I108fs|NFATC3_uc010vla.1_Frame_Shift_Del_p.I108fs|NFATC3_uc010vlb.1_Frame_Shift_Del_p.I108fs|NFATC3_uc010vlc.1_Frame_Shift_Del_p.I108fs	NM_173165	NP_775188	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells,	587	RHD.				inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		ATAGCCTCTATACCCGTTGAG	0.383													10	154	---	---	---	---					
SERPINB10	5273	broad.mit.edu	37	18	61584738	61584739	+	Frame_Shift_Ins	INS	-	A	A			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr18:61584738_61584739insA	uc010xev.1	+	3	307_308	c.217_218insA	c.(217-219)GAAfs	p.E73fs	SERPINB2_uc002ljp.1_Frame_Shift_Ins_p.E214fs|SERPINB2_uc002ljq.1_Frame_Shift_Ins_p.E187fs|SERPINB10_uc010xew.1_Frame_Shift_Ins_p.E73fs	NM_005024	NP_005015	P48595	SPB10_HUMAN	serine (or cysteine) proteinase inhibitor, clade	73						cytoplasm|nucleus	serine-type endopeptidase inhibitor activity			lung(1)|kidney(1)|skin(1)	3		Esophageal squamous(42;0.131)				CCCTGAAAGTGAAAAAAAAAGG	0.282													7	38	---	---	---	---					
LRRC8E	80131	broad.mit.edu	37	19	7960603	7960603	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr19:7960603delG	uc002mir.2	+	2	216	c.115delG	c.(115-117)GGGfs	p.G39fs		NM_025061	NP_079337	Q6NSJ5	LRC8E_HUMAN	leucine rich repeat containing 8 family, member	39	Helical; (Potential).					integral to membrane				lung(1)|pancreas(1)	2						GCTCATGATTGGGGTCTTTGG	0.627													17	51	---	---	---	---					
CALR	811	broad.mit.edu	37	19	13054650	13054658	+	In_Frame_Del	DEL	GAGGATGAG	-	-			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr19:13054650_13054658delGAGGATGAG	uc002mvu.2	+	9	1257_1265	c.1177_1185delGAGGATGAG	c.(1177-1185)GAGGATGAGdel	p.EDE396del	CALR_uc002mvv.2_RNA|RAD23A_uc002mvw.1_5'Flank|RAD23A_uc002mvx.1_5'Flank|RAD23A_uc002mvz.1_5'Flank|RAD23A_uc002mwa.1_5'Flank|RAD23A_uc002mvy.1_5'Flank|RAD23A_uc010xmw.1_5'Flank	NM_004343	NP_004334	P27797	CALR_HUMAN	calreticulin precursor	396_398	C-domain.|Asp/Glu/Lys-rich.				cell cycle arrest|cellular senescence|glucocorticoid receptor signaling pathway|negative regulation of neuron differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of steroid hormone receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of translation|peptide antigen assembly with MHC class I protein complex|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of phagocytosis|post-translational protein modification|protein export from nucleus|protein maturation by protein folding|protein N-linked glycosylation via asparagine|protein stabilization|regulation of apoptosis|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|extracellular space|MHC class I peptide loading complex|nucleus|perinuclear region of cytoplasm|polysome|proteinaceous extracellular matrix	androgen receptor binding|calcium ion binding|chaperone binding|complement component C1q binding|DNA binding|integrin binding|mRNA binding|protein binding involved in protein folding|sugar binding|ubiquitin protein ligase binding|unfolded protein binding|zinc ion binding			ovary(1)	1					Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Reteplase(DB00015)|Tenecteplase(DB00031)	ggacaaagatgaggatgaggaggatgagg	0.330													3	4	---	---	---	---					
ZNF225	7768	broad.mit.edu	37	19	44636328	44636328	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr19:44636328delT	uc002oyj.1	+	5	1804	c.1561delT	c.(1561-1563)TTTfs	p.F521fs	ZNF225_uc010eje.1_Frame_Shift_Del_p.F438fs|ZNF225_uc010ejf.1_Frame_Shift_Del_p.F521fs	NM_013362	NP_037494	Q9UK10	ZN225_HUMAN	zinc finger protein 225	521	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				TGGGAAAAGATTTACTCAGAA	0.388													12	115	---	---	---	---					
GPR155	151556	broad.mit.edu	37	2	175346653	175346657	+	Frame_Shift_Del	DEL	GTTAA	-	-			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr2:175346653_175346657delGTTAA	uc002uit.2	-	3	419_423	c.28_32delTTAAC	c.(28-33)TTAACCfs	p.L10fs	GPR155_uc002uiu.2_Frame_Shift_Del_p.L10fs|GPR155_uc002uiv.2_Frame_Shift_Del_p.L10fs|GPR155_uc010fqs.2_Frame_Shift_Del_p.L10fs	NM_001033045	NP_001028217	Q7Z3F1	GP155_HUMAN	G protein-coupled receptor 155 isoform 9	10_11					intracellular signal transduction|transmembrane transport	integral to membrane				ovary(1)	1						GACTGCAATGGTTAAGTTCTCTGCA	0.400													45	119	---	---	---	---					
CEP250	11190	broad.mit.edu	37	20	34064377	34064378	+	Frame_Shift_Ins	INS	-	T	T			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr20:34064377_34064378insT	uc002xcm.2	+	17	2491_2492	c.1820_1821insT	c.(1819-1821)GCTfs	p.A607fs	CEP250_uc010zve.1_5'UTR|CEP250_uc010zvd.1_RNA	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	607	Gln/Glu-rich.|Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			TTAAATGAGGCTTTGGCGTTAG	0.515													23	51	---	---	---	---					
PRMT2	3275	broad.mit.edu	37	21	48056904	48056905	+	Splice_Site	INS	-	AA	AA			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr21:48056904_48056905insAA	uc002zjx.2	+	3	353	c.39_splice	c.e3+2	p.Q13_splice	PRMT2_uc002zjw.2_Splice_Site_p.Q13_splice|PRMT2_uc002zjy.2_Splice_Site_p.Q13_splice|PRMT2_uc010gqm.2_Splice_Site_p.Q13_splice|PRMT2_uc011aga.1_Splice_Site_p.Q13_splice|PRMT2_uc011agb.1_Splice_Site_p.Q13_splice|PRMT2_uc011agc.1_Splice_Site_p.Q13_splice	NM_206962	NP_996845	P55345	ANM2_HUMAN	HMT1 hnRNP methyltransferase-like 1						developmental cell growth|induction of apoptosis|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of androgen receptor signaling pathway	cytosol|nucleus	androgen receptor binding|estrogen receptor binding|histone-arginine N-methyltransferase activity|peroxisome proliferator activated receptor binding|progesterone receptor binding|protein homodimerization activity|retinoic acid receptor binding|signal transducer activity|thyroid hormone receptor binding|transcription coactivator activity			ovary(1)	1	Breast(49;0.247)	Lung NSC(3;0.245)		Epithelial(3;1.03e-07)|OV - Ovarian serous cystadenocarcinoma(3;4.68e-07)|all cancers(3;7.48e-07)|Colorectal(79;0.167)|Lung(125;0.203)|LUSC - Lung squamous cell carcinoma(216;0.23)|READ - Rectum adenocarcinoma(84;0.248)		GAATCGCAGGTAATTTCCGTTC	0.421													12	40	---	---	---	---					
SAR1B	51128	broad.mit.edu	37	5	133956720	133956720	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr5:133956720delT	uc003kzq.2	-	4	328	c.81delA	c.(79-81)AAAfs	p.K27fs	SAR1B_uc003kzr.2_Frame_Shift_Del_p.K27fs	NM_001033503	NP_001028675	Q9Y6B6	SAR1B_HUMAN	SAR1a gene homolog 2	27					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi cisterna membrane	GTP binding|GTPase activity|metal ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GAAATACCAGTTTACCAGTTT	0.343													41	131	---	---	---	---					
MAML1	9794	broad.mit.edu	37	5	179192969	179192987	+	Frame_Shift_Del	DEL	GGGTCTGCAGGGCAGACCT	-	-			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr5:179192969_179192987delGGGTCTGCAGGGCAGACCT	uc003mkm.2	+	2	1221_1239	c.958_976delGGGTCTGCAGGGCAGACCT	c.(958-978)GGGTCTGCAGGGCAGACCTTTfs	p.G320fs	MAML1_uc003mkn.1_Frame_Shift_Del_p.G320fs	NM_014757	NP_055572	Q92585	MAML1_HUMAN	mastermind-like 1	320_326					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	peptide antigen binding|protein kinase binding|transcription coactivator activity			lung(4)|ovary(2)	6	all_cancers(89;0.000197)|all_epithelial(37;6.7e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0308)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGTGAGGGCCGGGTCTGCAGGGCAGACCTTTCTGGGGCC	0.571													19	71	---	---	---	---					
CADPS2	93664	broad.mit.edu	37	7	122130209	122130210	+	Frame_Shift_Ins	INS	-	A	A			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr7:122130209_122130210insA	uc010lkp.2	-	11	1940_1941	c.1777_1778insT	c.(1777-1779)TATfs	p.Y593fs	CADPS2_uc003vkg.3_Frame_Shift_Ins_p.Y293fs|CADPS2_uc010lkq.2_Frame_Shift_Ins_p.Y593fs	NM_017954	NP_060424	Q86UW7	CAPS2_HUMAN	Ca2+-dependent activator protein for secretion 2	593					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			ovary(1)|central_nervous_system(1)	2						AACTGGTTTATATGATTGACCT	0.376													39	104	---	---	---	---					
SVEP1	79987	broad.mit.edu	37	9	113265327	113265327	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chr9:113265327delG	uc010mtz.2	-	6	1811	c.1474delC	c.(1474-1476)CGGfs	p.R492fs	SVEP1_uc010mua.1_Frame_Shift_Del_p.R492fs|SVEP1_uc004beu.2_Frame_Shift_Del_p.R492fs	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	492	Sushi 2.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						CCCACACACCGGGGTTCTGGC	0.443													29	81	---	---	---	---					
Unknown	0	broad.mit.edu	37	M	8281	8281	+	RNA	DEL	C	-	-			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chrM:8281delC	uc004cou.3	+	1		c.696delC			uc011mfi.1_5'Flank|uc004cov.3_5'Flank					Homo sapiens mRNA expressed only in placental villi, clone SMAP42.																		CACCCCCTCTACCCCCTCTAG	0.413													5	1	---	---	---	---					
ATXN3L	92552	broad.mit.edu	37	X	13337247	13337248	+	Frame_Shift_Del	DEL	TG	-	-			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chrX:13337247_13337248delTG	uc010ned.2	-	1	1271_1272	c.806_807delCA	c.(805-807)ACAfs	p.T269fs		NM_001135995	NP_001129467	Q9H3M9	ATX3L_HUMAN	ataxin 3-like	269					protein deubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ubiquitin-specific protease activity			lung(2)|ovary(2)|large_intestine(1)|skin(1)	6						TTACACATGATGTCTTTGGAAG	0.426													205	159	---	---	---	---					
TSIX	9383	broad.mit.edu	37	X	73047124	73047125	+	RNA	DEL	AC	-	-			TCGA-BQ-5892-01A-11D-1589-08	TCGA-BQ-5892-11A-01D-1589-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e208c0a-d4dc-41d8-9f75-740d3fbf33ba	2684973c-b534-4ced-a232-197ba7e30757	g.chrX:73047124_73047125delAC	uc004ebn.2	+	1		c.35085_35086delAC			XIST_uc004ebm.1_RNA	NR_003255				Homo sapiens XIST antisense RNA (non-protein coding) (TSIX), non-coding RNA.												0						GCCACACATGACACACACACAC	0.470													7	105	---	---	---	---					
