Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CSMD2	114784	broad.mit.edu	37	1	34180229	34180229	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr1:34180229C>T	uc001bxn.1	-	21	3273	c.3244G>A	c.(3244-3246)GGC>AGC	p.G1082S	CSMD2_uc001bxm.1_Missense_Mutation_p.G1122S	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1082	Sushi 6.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CGCCGTCTGCCCCCCAGGCAC	0.607000													56	27					0	0	0.000781405	0	0
FUBP1	8880	broad.mit.edu	37	1	78444626	78444626	+	Silent	SNP	G	A	A			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr1:78444626G>A	uc001dii.2	-	1	152	c.63C>T	c.(61-63)GGC>GGT	p.G21G	FUBP1_uc001dih.3_RNA|FUBP1_uc010orm.1_Silent_p.G21G|DNAJB4_uc010orn.1_5'Flank	NM_003902	NP_003893	Q96AE4	FUBP1_HUMAN	far upstream element-binding protein	21	Gly-rich.				transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(2)|lung(1)	3						caccaccaccgccgccaccac	0.488000													22	8					0	0	0.000295444	0	0
ENSA	2029	broad.mit.edu	37	1	150601936	150601936	+	Missense_Mutation	SNP	T	G	G	rs148754482	byFrequency	TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr1:150601936T>G	uc001eve.2	-	1	163	c.11A>C	c.(10-12)AAA>ACA	p.K4T	ENSA_uc001evd.2_Missense_Mutation_p.K4T|ENSA_uc009wly.2_Missense_Mutation_p.K4T|ENSA_uc001evg.2_Missense_Mutation_p.K4T|ENSA_uc001evh.2_Missense_Mutation_p.K4T|ENSA_uc009wlz.1_Missense_Mutation_p.K4T|ENSA_uc001evi.2_Missense_Mutation_p.K4T	NM_004436	NP_004427	O43768	ENSA_HUMAN	endosulfine alpha isoform 3	4					cell division|G2/M transition of mitotic cell cycle|mitosis|response to nutrient|transport	cytoplasm	ion channel inhibitor activity|protein phosphatase 2A binding|protein phosphatase inhibitor activity|protein phosphatase type 2A regulator activity|receptor binding			central_nervous_system(1)	1	all_cancers(9;3.09e-52)|all_epithelial(9;4.47e-43)|all_lung(15;1.09e-34)|Lung NSC(24;4.04e-31)|Breast(34;0.000615)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;9.85e-23)|all cancers(9;5.06e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.67e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000701)|LUSC - Lung squamous cell carcinoma(543;0.171)			TTCTTCTTGTTTCTGGGACAT	0.662000													23	30					0	0	0.000409698	0	0
HORMAD1	84072	broad.mit.edu	37	1	150689613	150689613	+	Splice_Site	SNP	C	T	T			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr1:150689613C>T	uc001evk.1	-	3	284	c.178_splice	c.e3+1	p.D60_splice	HORMAD1_uc001evl.1_Splice_Site_p.D60_splice|HORMAD1_uc001evm.1_Splice_Site_p.W10_splice	NM_032132	NP_115508	Q86X24	HORM1_HUMAN	HORMA domain containing 1						blastocyst development|cell differentiation|meiotic DNA double-strand break formation|meiotic recombination checkpoint|meiotic sister chromatid cohesion|mitosis|oogenesis|regulation of homologous chromosome segregation|spermatogenesis|synaptonemal complex assembly	chromosome|nucleus				ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.23e-52)|all_epithelial(9;4.68e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.0009)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;2.32e-23)|all cancers(9;5.21e-23)|OV - Ovarian serous cystadenocarcinoma(6;6.72e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			TATTGTATTACCATCTAGATA	0.289000													23	45					0	0	0.000375601	0	0
FMO2	2327	broad.mit.edu	37	1	171174553	171174553	+	Missense_Mutation	SNP	C	A	A			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr1:171174553C>A	uc001ghk.1	+	7	1080	c.963C>A	c.(961-963)AAC>AAA	p.N321K	FMO2_uc010pmd.1_Missense_Mutation_p.N101K	NM_001460	NP_001451	Q99518	FMO2_HUMAN	flavin containing monooxygenase 2	321					drug metabolic process|NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|host cell microsome|integral to membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TGGAGGAGAACATTGATGTCA	0.398000													14	35					7.93312e-07	1.68849e-05	0.000219431	1	0
SLC16A9	220963	broad.mit.edu	37	10	61413807	61413807	+	Missense_Mutation	SNP	A	G	G			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr10:61413807A>G	uc010qig.1	-	5	1426	c.977T>C	c.(976-978)CTT>CCT	p.L326P		NM_194298	NP_919274	Q7RTY1	MOT9_HUMAN	solute carrier family 16 (monocarboxylic acid	326	Cytoplasmic (Potential).				urate metabolic process	integral to membrane|plasma membrane	symporter activity			skin(2)|ovary(1)	3						ATCTTCCATAAGTAATGAAGG	0.363000													26	39					0	0	0.000878237	0	0
PDLIM1	9124	broad.mit.edu	37	10	96998413	96998413	+	Missense_Mutation	SNP	T	G	G			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr10:96998413T>G	uc001kkh.2	-	6	824	c.715A>C	c.(715-717)AGT>CGT	p.S239R	PDLIM1_uc001kki.2_Missense_Mutation_p.S239R|PDLIM1_uc009xuv.2_Intron|PDLIM1_uc001kkj.1_Missense_Mutation_p.S239R	NM_020992	NP_066272	O00151	PDLI1_HUMAN	PDZ and LIM domain 1	239					response to oxidative stress	cytoplasm|cytoskeleton	zinc ion binding				0		Colorectal(252;0.083)		Epithelial(162;1.64e-06)|all cancers(201;3.71e-05)		GCTTTAACACTTCTGAATCCT	0.468000													21	37					0	0	0.00152264	0	0
DNMBP	23268	broad.mit.edu	37	10	101646325	101646325	+	Missense_Mutation	SNP	G	C	C			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr10:101646325G>C	uc001kqj.2	-	13	3442	c.3350C>G	c.(3349-3351)CCC>CGC	p.P1117R	DNMBP_uc010qpl.1_Missense_Mutation_p.P53R|DNMBP_uc001kqg.2_Missense_Mutation_p.P405R|DNMBP_uc001kqh.2_Missense_Mutation_p.P749R	NM_015221	NP_056036	Q6XZF7	DNMBP_HUMAN	dynamin binding protein	1117	BAR.				intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(5)|skin(1)	6		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		CAGCTTATGGGGCCCTGTAAA	0.502000													64	117					0	0	0.000781405	0	0
SLK	9748	broad.mit.edu	37	10	105750528	105750528	+	Missense_Mutation	SNP	A	G	G			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr10:105750528A>G	uc001kxo.1	+	2	280	c.246A>G	c.(244-246)ATA>ATG	p.I82M	SLK_uc001kxp.1_Missense_Mutation_p.I82M	NM_014720	NP_055535	Q9H2G2	SLK_HUMAN	serine/threonine kinase 2	82	Protein kinase.				apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			ovary(2)|stomach(2)|skin(2)|lung(1)|kidney(1)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		AGATTGACATATTAGCATCTT	0.363000													24	34					0	0	0.000720815	0	0
MUC5B	727897	broad.mit.edu	37	11	1247945	1247945	+	Missense_Mutation	SNP	C	G	G			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr11:1247945C>G	uc009ycr.1	+	20	2394	c.2268C>G	c.(2266-2268)AAC>AAG	p.N756K	MUC5B_uc009yct.1_Missense_Mutation_p.N100K|MUC5B_uc001ltb.2_Missense_Mutation_p.N100K|MUC5B_uc001lta.2_5'Flank	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	100	VWFD 1.			FPGLCN -> LPCLCK (in Ref. 2; AAC67545).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GCCTTTGCAACTACGTGTTCT	0.632000													7	22					0	0	8.12818e-05	0	0
PRKRIR	5612	broad.mit.edu	37	11	76063689	76063689	+	Missense_Mutation	SNP	G	C	C			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr11:76063689G>C	uc001oxh.1	-	5	505	c.505C>G	c.(505-507)CTA>GTA	p.L169V	PRKRIR_uc010rrz.1_5'UTR	NM_004705	NP_004696	O43422	P52K_HUMAN	protein-kinase, interferon-inducible double	169					negative regulation of cell proliferation|response to stress|signal transduction		DNA binding|metal ion binding|protein dimerization activity			ovary(2)|pancreas(1)	3						ATTTCAAATAGAGATTTTAGG	0.413000													16	7					0	0	0.000308642	0	0
MLL2	8085	broad.mit.edu	37	12	49436618	49436618	+	Missense_Mutation	SNP	C	G	G			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr12:49436618C>G	uc001rta.3	-	26	5688	c.5688G>C	c.(5686-5688)AAG>AAC	p.K1896N		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1896					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CCAGAACATCCTTGAAGAGCT	0.537000			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			3	51					0	0	6.4e-05	0	0
MON2	23041	broad.mit.edu	37	12	62959064	62959064	+	Missense_Mutation	SNP	A	G	G			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr12:62959064A>G	uc001sre.2	+	27	4471	c.4080A>G	c.(4078-4080)ATA>ATG	p.I1360M	MON2_uc009zqj.2_Missense_Mutation_p.I1360M|MON2_uc010ssl.1_Missense_Mutation_p.I1288M|MON2_uc010ssm.1_Missense_Mutation_p.I1337M|MON2_uc010ssn.1_Missense_Mutation_p.I1360M|MON2_uc001srf.2_Missense_Mutation_p.I1123M|MON2_uc001srg.2_Missense_Mutation_p.I235M	NM_015026	NP_055841	Q7Z3U7	MON2_HUMAN	MON2 homolog	1361					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		ATCCAGCTATATTTGACCAGT	0.348000													73	90					0	0	0.000781405	0	0
RNF10	9921	broad.mit.edu	37	12	121013746	121013747	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr12:121013746_121013747CC>AA	uc001typ.3	+	16	2835_2836	c.2352_2353CC>AA	c.(2350-2355)CCCCTC>CCAATC	p.L785I	RNF10_uc010szk.1_RNA|RNF10_uc001tyq.3_Missense_Mutation_p.L696I	NM_014868	NP_055683	Q8N5U6	RNF10_HUMAN	ring finger protein 10	785					negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTTCAGATCCCCTCTCTGGTAA	0.322000													8	182					0	0	6.4e-05	0	0
EP400	57634	broad.mit.edu	37	12	132472272	132472272	+	Missense_Mutation	SNP	T	A	A			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr12:132472272T>A	uc001ujn.2	+	6	2281	c.2246T>A	c.(2245-2247)ATT>AAT	p.I749N	EP400_uc001ujl.2_Missense_Mutation_p.I748N|EP400_uc001ujm.2_Missense_Mutation_p.I749N|EP400_uc001ujj.1_Missense_Mutation_p.I712N|EP400_uc001ujk.2_Missense_Mutation_p.I785N	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	785					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		CATCAGCGCATTGCGGAGCTG	0.577000													9	26					0	0	0.000978159	0	0
EP400	57634	broad.mit.edu	37	12	132472274	132472274	+	Missense_Mutation	SNP	G	C	C			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr12:132472274G>C	uc001ujn.2	+	6	2283	c.2248G>C	c.(2248-2250)GCG>CCG	p.A750P	EP400_uc001ujl.2_Missense_Mutation_p.A749P|EP400_uc001ujm.2_Missense_Mutation_p.A750P|EP400_uc001ujj.1_Missense_Mutation_p.A713P|EP400_uc001ujk.2_Missense_Mutation_p.A786P	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	786					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		TCAGCGCATTGCGGAGCTGAG	0.577000													10	26					0	0	0.000978159	0	0
KBTBD7	84078	broad.mit.edu	37	13	41766948	41766948	+	Silent	SNP	A	T	T			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr13:41766948A>T	uc001uxw.1	-	1	1755	c.1446T>A	c.(1444-1446)GTT>GTA	p.V482V	uc001uxv.1_Intron	NM_032138	NP_115514	Q8WVZ9	KBTB7_HUMAN	kelch repeat and BTB (POZ) domain containing 7	482	Kelch 2.						protein binding			ovary(1)	1		Lung NSC(96;0.000105)|Breast(139;0.00715)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.21e-09)|Epithelial(112;6.99e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000196)|GBM - Glioblastoma multiforme(144;0.000857)|BRCA - Breast invasive adenocarcinoma(63;0.0669)		GATAGTTCTGAACCACTATGA	0.433000													21	22					0	0	0.00152264	0	0
DOCK9	23348	broad.mit.edu	37	13	99540613	99540613	+	Splice_Site	SNP	C	T	T			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr13:99540613C>T	uc001vnt.2	-	17	2035	c.1980_splice	c.e17+1	p.K660_splice	DOCK9_uc001vnw.2_Splice_Site_p.K659_splice|DOCK9_uc001vnv.1_Splice_Site|DOCK9_uc010tir.1_Splice_Site_p.K660_splice|DOCK9_uc010tis.1_Splice_Site_p.K659_splice|DOCK9_uc010tit.1_Splice_Site_p.K660_splice|DOCK9_uc010afu.1_Splice_Site_p.K475_splice	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a						blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TTCACACTCACCTTGGCAAAA	0.398000													19	168					0	0	0.00121646	0	0
FAM71D	161142	broad.mit.edu	37	14	67688507	67688507	+	Missense_Mutation	SNP	C	A	A			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr14:67688507C>A	uc001xja.1	+	7	1426	c.1172C>A	c.(1171-1173)ACT>AAT	p.T391N	FAM71D_uc010aqn.1_RNA	NM_173526	NP_775797	Q8N9W8	FA71D_HUMAN	hypothetical protein LOC161142	391										ovary(1)	1		all_hematologic(31;0.0116)		all cancers(60;0.00107)|BRCA - Breast invasive adenocarcinoma(234;0.00993)|OV - Ovarian serous cystadenocarcinoma(108;0.012)		AGCTTGAGAACTGAATCAAAC	0.353000													7	34					0.000442599	0.00921098	0.000442599	1	0
DPF3	8110	broad.mit.edu	37	14	73238479	73238479	+	Missense_Mutation	SNP	T	G	G			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr14:73238479T>G	uc001xnc.2	-	2	168	c.155A>C	c.(154-156)AAC>ACC	p.N52T	DPF3_uc001xnf.2_RNA|DPF3_uc010ari.1_Missense_Mutation_p.N52T|DPF3_uc010ttq.1_Missense_Mutation_p.N62T	NM_012074	NP_036206	Q92784	DPF3_HUMAN	D4, zinc and double PHD fingers, family 3	52					chromatin modification|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nBAF complex	nucleic acid binding|zinc ion binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00649)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		GATGTAGCAGTTGTTCTGGGC	0.622000													29	38					0	0	0.000409698	0	0
PPP4R4	57718	broad.mit.edu	37	14	94640864	94640864	+	Missense_Mutation	SNP	T	C	C			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr14:94640864T>C	uc001ycs.1	+	1	216	c.62T>C	c.(61-63)ATG>ACG	p.M21T	PPP4R4_uc001ycr.2_Missense_Mutation_p.M21T	NM_058237	NP_478144	Q6NUP7	PP4R4_HUMAN	HEAT-like repeat-containing protein isoform 1	21						cytoplasm|protein serine/threonine phosphatase complex	protein binding			skin(3)|upper_aerodigestive_tract(1)	4						TTCGGTTACATGGAGGACCTG	0.617000													9	28					0	0	0.000673444	0	0
DLK1	8788	broad.mit.edu	37	14	101201161	101201161	+	Silent	SNP	C	T	T	rs116711857	byFrequency	TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr14:101201161C>T	uc001yhs.3	+	5	1233	c.1080C>T	c.(1078-1080)GCC>GCT	p.A360A	DLK1_uc001yhu.3_Silent_p.A287A	NM_003836	NP_003827	P80370	DLK1_HUMAN	delta-like 1 homolog precursor	360	Cytoplasmic (Potential).				multicellular organismal development	extracellular space|integral to membrane|soluble fraction				ovary(2)|breast(1)|skin(1)	4		Melanoma(154;0.155)				AGGACCTGGCCGTCAACATCA	0.567000													38	46					0	0	0.000953801	0	0
OCA2	4948	broad.mit.edu	37	15	28090200	28090200	+	Splice_Site	SNP	T	A	A			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr15:28090200T>A	uc001zbh.3	-	23	2449	c.2339_splice	c.e23-1	p.G780_splice	OCA2_uc010ayv.2_Splice_Site_p.G756_splice	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II						eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		TCCCGTTACCTAAAGTCAAAA	0.413000									Oculocutaneous_Albinism				20	34					0	0	0.000958276	0	0
ZNF609	23060	broad.mit.edu	37	15	64966235	64966235	+	Silent	SNP	G	T	T			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr15:64966235G>T	uc002ann.2	+	4	1182	c.1182G>T	c.(1180-1182)GGG>GGT	p.G394G		NM_015042	NP_055857	O15014	ZN609_HUMAN	zinc finger protein 609	394						nucleus	zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						ACAGCAAAGGGACCAGTAACA	0.577000													44	78					4.10826e-27	9.05267e-26	0.000781405	1	0
THSD4	79875	broad.mit.edu	37	15	72063439	72063439	+	Missense_Mutation	SNP	G	C	C			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr15:72063439G>C	uc002atb.1	+	16	2885	c.2806G>C	c.(2806-2808)GAA>CAA	p.E936Q	THSD4_uc002ate.2_Missense_Mutation_p.E576Q|THSD4_uc002atg.1_Missense_Mutation_p.E139Q	NM_024817	NP_079093	Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	936	TSP type-1 6.					proteinaceous extracellular matrix	metalloendopeptidase activity			ovary(2)	2						TCGGGTCCGGGAAGTGCGGTG	0.507000													51	67					0	0	0.000781405	0	0
BNC1	646	broad.mit.edu	37	15	83932666	83932666	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr15:83932666G>A	uc002bjt.1	-	4	1425	c.1337C>T	c.(1336-1338)ACG>ATG	p.T446M	BNC1_uc010uos.1_Missense_Mutation_p.T434M	NM_001717	NP_001708	Q01954	BNC1_HUMAN	basonuclin 1	446					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						GTCTGGGGACGTCACTGTGAA	0.527000													26	37					0	0	0.000586117	0	0
ADAMTS17	170691	broad.mit.edu	37	15	100871170	100871170	+	Silent	SNP	G	A	A			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr15:100871170G>A	uc002bvv.1	-	3	619	c.540C>T	c.(538-540)ATC>ATT	p.I180I	ADAMTS17_uc002bvx.1_5'UTR	NM_139057	NP_620688	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1	180					proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)		ATTTGCGCCTGATCAGATGTT	0.582000													42	34					0	0	0.00195071	0	0
PCSK6	5046	broad.mit.edu	37	15	101933522	101933522	+	Silent	SNP	G	A	A			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr15:101933522G>A	uc002bwy.2	-	9	1418	c.1104C>T	c.(1102-1104)TCC>TCT	p.S368S	PCSK6_uc010bpd.2_Silent_p.S238S|PCSK6_uc010bpe.2_Silent_p.S368S|PCSK6_uc002bxa.2_Silent_p.S368S|PCSK6_uc002bxb.2_Silent_p.S368S|PCSK6_uc002bxc.1_Silent_p.S368S|PCSK6_uc002bxd.1_Silent_p.S368S|PCSK6_uc002bxe.2_Silent_p.S368S|PCSK6_uc002bxg.1_Silent_p.S368S	NM_002570	NP_002561	P29122	PCSK6_HUMAN	paired basic amino acid cleaving system 4	368	Catalytic.				glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			pancreas(2)	2	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CGCTGCTGACGGAGATGGTGT	0.597000													16	20					0	0	0.000566183	0	0
IRX6	79190	broad.mit.edu	37	16	55360382	55360382	+	Silent	SNP	G	A	A			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr16:55360382G>A	uc002ehy.2	+	2	713	c.180G>A	c.(178-180)GCG>GCA	p.A60A	IRX6_uc002ehx.2_Silent_p.A60A|IRX6_uc010ccb.1_RNA	NM_024335	NP_077311	P78412	IRX6_HUMAN	iroquois homeobox protein 6	60						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(1)	6						TGGGCAGTGCGCGACCGGAGC	0.657000													22	16					0	0	0.000295444	0	0
CDH5	1003	broad.mit.edu	37	16	66413245	66413245	+	Missense_Mutation	SNP	A	C	C			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr16:66413245A>C	uc002eom.3	+	2	161	c.5A>C	c.(4-6)CAG>CCG	p.Q2P	CDH5_uc002eon.1_Missense_Mutation_p.Q2P	NM_001795	NP_001786	P33151	CADH5_HUMAN	cadherin 5, type 2 preproprotein	2					adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		GGGAAGATGCAGAGGCTCATG	0.453000													48	161					0	0	0.000781405	0	0
PLCG2	5336	broad.mit.edu	37	16	81922847	81922847	+	Missense_Mutation	SNP	A	T	T			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr16:81922847A>T	uc002fgt.2	+	10	988	c.836A>T	c.(835-837)GAA>GTA	p.E279V	PLCG2_uc010chg.1_Missense_Mutation_p.E279V	NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	279					intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8						ACCATGCGTGAAACTGCTGAG	0.463000													9	19					0	0	0.000442599	0	0
P2RX5	5026	broad.mit.edu	37	17	3583061	3583061	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr17:3583061G>A	uc002fwi.2	-	11	1366	c.1082C>T	c.(1081-1083)TCC>TTC	p.S361F	P2RX5_uc002fwd.2_RNA|P2RX5_uc002fwh.1_Missense_Mutation_p.S360F|P2RX5_uc010vrx.1_Missense_Mutation_p.S301F|P2RX5_uc002fwj.2_Missense_Mutation_p.S336F|P2RX5_uc002fwk.2_Missense_Mutation_p.S360F|P2RX5_uc002fwl.2_Missense_Mutation_p.S337F	NM_002561	NP_002552	Q93086	P2RX5_HUMAN	purinergic receptor P2X5 isoform A	361	Cytoplasmic (Potential).				nervous system development|positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity				0						GGCCTCCTGGGAACTGTCTTC	0.647000													8	20					0	0	0.000442599	0	0
DNAH9	1770	broad.mit.edu	37	17	11593357	11593357	+	Silent	SNP	G	A	A	rs140079277	byFrequency	TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr17:11593357G>A	uc002gne.2	+	20	4286	c.4218G>A	c.(4216-4218)GCG>GCA	p.A1406A	DNAH9_uc010coo.2_Silent_p.A700A	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	1406	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CCACCCTAGCGCACCTGCTGC	0.577000													7	21					0	0	0.000274275	0	0
SREBF1	6720	broad.mit.edu	37	17	17722461	17722461	+	Missense_Mutation	SNP	T	C	C			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr17:17722461T>C	uc002gru.1	-	5	1128	c.934A>G	c.(934-936)AGC>GGC	p.S312G	SREBF1_uc002grp.1_5'Flank|SREBF1_uc002grq.1_5'UTR|SREBF1_uc002grr.1_Missense_Mutation_p.S58G|SREBF1_uc002grs.1_Missense_Mutation_p.S288G|SREBF1_uc002grt.1_Missense_Mutation_p.S342G|SREBF1_uc010cpp.1_Missense_Mutation_p.S288G|SREBF1_uc010cpq.1_Missense_Mutation_p.S312G	NM_004176	NP_004167	P36956	SRBP1_HUMAN	sterol regulatory element binding transcription	312	Cytoplasmic (Potential).|Interaction with LMNA (By similarity).				cellular response to starvation|cholesterol metabolic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleus	protein binding|protein binding|sequence-specific DNA binding transcription factor activity|sterol response element binding			skin(1)	1						GGGGCCTTGCTGCCAGCTGCG	0.607000													25	40					0	0	0.001512	0	0
KRTAP4-9	100132386	broad.mit.edu	37	17	39262083	39262083	+	Missense_Mutation	SNP	A	C	C	rs75392608		TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr17:39262083A>C	uc010wfp.1	+	1	443	c.443A>C	c.(442-444)AAC>ACC	p.N148T		NM_001146041	NP_001139513	Q9BYQ8	KRA49_HUMAN	keratin associated protein 4-9	148	29 X 5 AA repeats of C-C-[RQVHIEK]- [SPTR]-[VSTQCRNP].|24.					keratin filament					0						tgccagcccaactgctgccgc	0.100000													4	21					0	0	0.000602214	0	0
POLG2	11232	broad.mit.edu	37	17	62486981	62486981	+	Missense_Mutation	SNP	C	G	G			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr17:62486981C>G	uc002jei.2	-	4	984	c.901G>C	c.(901-903)GAA>CAA	p.E301Q	POLG2_uc010deg.1_Missense_Mutation_p.E301Q	NM_007215	NP_009146	Q9UHN1	DPOG2_HUMAN	DNA polymerase subunit gamma-2, mitochondrial	301					DNA repair|DNA-dependent DNA replication|glycyl-tRNA aminoacylation	mitochondrial chromosome	ATP binding|DNA-directed DNA polymerase activity|glycine-tRNA ligase activity|identical protein binding|single-stranded DNA binding			central_nervous_system(1)	1	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;4.97e-11)			CACAGGGTTTCTATTAACTCC	0.408000													33	35					0	0	0.000491102	0	0
Unknown	0	broad.mit.edu	37	17	78293016	78293016	+	Silent	SNP	C	G	G			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr17:78293016C>G	uc002jyf.2	+	17	3071	c.2928C>G	c.(2926-2928)GCC>GCG	p.A976A	uc002jyg.1_Silent_p.A707A	NM_020954	NP_066005			hypothetical protein LOC57714																		AGATCACTGCCTACTGCAATA	0.522000													60	110					0	0	0.000781405	0	0
SIRT7	51547	broad.mit.edu	37	17	79870325	79870325	+	Silent	SNP	G	A	A			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr17:79870325G>A	uc002kcj.1	-	10	1203	c.1170C>T	c.(1168-1170)TGC>TGT	p.C390C	PCYT2_uc010wva.1_5'Flank|PCYT2_uc010wvb.1_5'Flank|PCYT2_uc002kce.1_5'Flank|PCYT2_uc002kcf.1_5'Flank|PCYT2_uc002kcg.1_5'Flank|PCYT2_uc002kch.1_5'Flank|PCYT2_uc002kci.1_5'Flank|PCYT2_uc010dii.1_5'Flank|PCYT2_uc010wvc.1_5'Flank|SIRT7_uc002kck.1_Silent_p.C241C|SIRT7_uc002kcl.1_Silent_p.C308C	NM_016538	NP_057622	Q9NRC8	SIRT7_HUMAN	sirtuin 7	390					chromatin silencing|positive regulation of transcription on exit from mitosis|protein deacetylation|rRNA transcription	cytoplasm|nucleolus organizer region	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ binding|protein binding|zinc ion binding				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0165)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			TGCGTTTTGTGCAGCCCCTGC	0.597000													84	93					0	0	0.000781405	0	0
USP14	9097	broad.mit.edu	37	18	163336	163336	+	Missense_Mutation	SNP	T	G	G			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr18:163336T>G	uc002kkf.1	+	2	261	c.45T>G	c.(43-45)TTT>TTG	p.F15L	USP14_uc002kkg.1_Missense_Mutation_p.F15L|USP14_uc010wyr.1_Missense_Mutation_p.F15L	NM_005151	NP_005142	P54578	UBP14_HUMAN	ubiquitin specific protease 14 isoform a	15	Ubiquitin-like.				regulation of chemotaxis|regulation of proteasomal protein catabolic process|ubiquitin-dependent protein catabolic process	cell surface|cytoplasmic membrane-bounded vesicle|plasma membrane|proteasome complex	cysteine-type endopeptidase activity|endopeptidase inhibitor activity|proteasome binding|tRNA guanylyltransferase activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)	2		all_cancers(4;0.0896)|Myeloproliferative disorder(11;0.0412)				AGGAGAAATTTGAAGGTGTAG	0.373000													16	7					0	0	0.000422831	0	0
EPS15L1	58513	broad.mit.edu	37	19	16503123	16503124	+	Missense_Mutation	DNP	GT	AA	AA			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr19:16503123_16503124GT>AA	uc002ndz.1	-	19	2100_2101	c.2094_2095AC>TT	c.(2092-2097)TTACCT>TTTTCT	p.698_699LP>FS	EPS15L1_uc002ndx.2_Missense_Mutation_p.698_699LP>FS|EPS15L1_uc002ndy.2_RNA|EPS15L1_uc010xpe.1_Missense_Mutation_p.588_589LP>FS|EPS15L1_uc010xpf.1_Missense_Mutation_p.601_602LP>FS|EPS15L1_uc002nea.1_Missense_Mutation_p.698_699LP>FS|EPS15L1_uc010eah.1_Missense_Mutation_p.700_701LP>FS	NM_021235	NP_067058	Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway	698_699	15 X 3 AA repeats of D-P-F.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			ovary(3)|skin(2)	5						ACCTTCGAAGGTAAGGAAGGGT	0.559000													36	32					0	0	6.4e-05	0	0
EPS15L1	58513	broad.mit.edu	37	19	16551694	16551694	+	Silent	SNP	A	G	G			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr19:16551694A>G	uc002ndz.1	-	4	198	c.192T>C	c.(190-192)GGT>GGC	p.G64G	EPS15L1_uc002ndx.2_Silent_p.G64G|EPS15L1_uc002ndy.2_RNA|EPS15L1_uc010xpf.1_Splice_Site|EPS15L1_uc002nea.1_Silent_p.G64G|EPS15L1_uc010eah.1_Silent_p.G64G|EPS15L1_uc002nec.1_Silent_p.G64G	NM_021235	NP_067058	Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway	64	EH 1.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			ovary(3)|skin(2)	5						AGAACCCTTTACCTTCTGGAT	0.527000													152	236					0	0	0.000781405	0	0
ELL	8178	broad.mit.edu	37	19	18557590	18557590	+	Silent	SNP	G	A	A			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr19:18557590G>A	uc002njh.2	-	9	1572	c.1500C>T	c.(1498-1500)CCC>CCT	p.P500P	ELL_uc010ebq.2_Silent_p.P443P|ELL_uc002njg.2_Silent_p.P367P	NM_006532	NP_006523	P55199	ELL_HUMAN	elongation factor RNA polymerase II	500					positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	Cajal body|nuclear speck|transcription elongation factor complex	protein binding			lung(1)	1				GBM - Glioblastoma multiforme(1328;7.81e-07)		ACGTGGACGTGGGAACACTGG	0.607000			T	MLL	AL								13	18					0	0	0.000308642	0	0
ZNF708	7562	broad.mit.edu	37	19	21493348	21493348	+	Missense_Mutation	SNP	A	G	G			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr19:21493348A>G	uc002npq.1	-	2	283	c.85T>C	c.(85-87)TAT>CAT	p.Y29H	ZNF708_uc002npr.1_Intron|ZNF708_uc010ecs.1_Intron	NM_021269	NP_067092	P17019	ZN708_HUMAN	zinc finger protein 708	29	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(4)|skin(2)	6						ACATTCCTATATAAATTCTGC	0.333000													38	42					0	0	0.00148497	0	0
ZNF30	90075	broad.mit.edu	37	19	35434184	35434184	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr19:35434184G>A	uc010edp.1	+	5	692	c.314G>A	c.(313-315)TGT>TAT	p.C105Y	ZNF30_uc002nxf.2_Missense_Mutation_p.C24Y|ZNF30_uc010edq.1_Missense_Mutation_p.C106Y|ZNF30_uc010edr.1_Missense_Mutation_p.C106Y	NM_194325	NP_919306	P17039	ZNF30_HUMAN	zinc finger protein 30 isoform b	105					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_lung(56;8.38e-08)|Lung NSC(56;1.31e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)	GBM - Glioblastoma multiforme(1328;0.0265)		TCTGAAAACTGTCCATCTTTT	0.328000													20	20					0	0	0.000958276	0	0
BCAM	4059	broad.mit.edu	37	19	45322619	45322619	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr19:45322619C>T	uc002ozu.2	+	12	1534	c.1490C>T	c.(1489-1491)CCC>CTC	p.P497L	BCAM_uc002ozt.1_Missense_Mutation_p.P497L	NM_005581	NP_005572	P50895	BCAM_HUMAN	basal cell adhesion molecule isoform 1	497	Extracellular (Potential).|Ig-like C2-type 3.				cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			skin(1)	1	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)				GAGCCAATCCCCGGACGGCAG	0.662000													17	20					0	0	0.000958276	0	0
FCAR	2204	broad.mit.edu	37	19	55385758	55385758	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr19:55385758C>T	uc002qhr.1	+	1	210	c.13C>T	c.(13-15)CAG>TAG	p.Q5*	FCAR_uc002qhq.2_Nonsense_Mutation_p.Q5*|FCAR_uc002qhs.1_RNA|FCAR_uc002qht.1_5'UTR|FCAR_uc010esi.1_5'UTR|FCAR_uc002qhu.1_Nonsense_Mutation_p.Q5*|FCAR_uc002qhv.1_Nonsense_Mutation_p.Q5*|FCAR_uc002qhw.1_Nonsense_Mutation_p.Q5*|FCAR_uc002qhx.1_Nonsense_Mutation_p.Q5*|FCAR_uc002qhy.1_Nonsense_Mutation_p.Q5*|FCAR_uc002qhz.1_Nonsense_Mutation_p.Q5*|FCAR_uc002qia.1_Nonsense_Mutation_p.Q5*	NM_002000	NP_001991	P24071	FCAR_HUMAN	Fc alpha receptor isoform a precursor	5					immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(193;0.0443)		GGACCCCAAACAGACCACCCT	0.483000													38	59					0	0	0.000781405	0	0
ASAP2	8853	broad.mit.edu	37	2	9515020	9515020	+	Missense_Mutation	SNP	G	C	C			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr2:9515020G>C	uc002qzh.2	+	17	2033	c.1693G>C	c.(1693-1695)GCT>CCT	p.A565P	ASAP2_uc002qzi.2_Missense_Mutation_p.A565P	NM_003887	NP_003878	O43150	ASAP2_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	565					regulation of ARF GTPase activity	Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|protein binding|zinc ion binding				0						ATTGCTCCAAGCTTATGCTGA	0.438000													47	75					0	0	0.000781405	0	0
HEATR5B	54497	broad.mit.edu	37	2	37235951	37235951	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr2:37235951G>A	uc002rpp.1	-	28	4421	c.4325C>T	c.(4324-4326)TCA>TTA	p.S1442L	HEATR5B_uc010ezy.1_Missense_Mutation_p.S26L|HEATR5B_uc002rpq.3_Missense_Mutation_p.S26L	NM_019024	NP_061897	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	1442							binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)				TTTTGGTTTTGACTCTGCTTC	0.323000													64	89					0	0	0.000781405	0	0
CLASP1	23332	broad.mit.edu	37	2	122122716	122122716	+	Missense_Mutation	SNP	A	C	C			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr2:122122716A>C	uc002tnc.2	-	35	4421	c.4031T>G	c.(4030-4032)TTC>TGC	p.F1344C	CLASP1_uc010yyv.1_Missense_Mutation_p.F390C|CLASP1_uc002tmz.2_Missense_Mutation_p.F429C|CLASP1_uc002tna.2_Missense_Mutation_p.F390C|CLASP1_uc010yyw.1_RNA|CLASP1_uc002tnb.2_RNA|CLASP1_uc010yyx.1_RNA|CLASP1_uc010yyy.1_RNA|CLASP1_uc010yyz.1_Missense_Mutation_p.F1285C|CLASP1_uc010yza.1_Missense_Mutation_p.F1277C|CLASP1_uc010yzb.1_RNA|CLASP1_uc010yzc.1_RNA|CLASP1_uc002tmy.2_Missense_Mutation_p.F180C|CLASP1_uc002tnf.2_Missense_Mutation_p.F246C	NM_015282	NP_056097	Q7Z460	CLAP1_HUMAN	CLIP-associating protein 1 isoform 1	1344	HEAT 6.|Interaction with PHLDB2 and RSN.|Localization to kinetochores.|Interaction with CLIP2 (By similarity).				axon guidance|cell division|establishment or maintenance of cell polarity|exit from mitosis|G2/M transition of mitotic cell cycle|microtubule anchoring|microtubule bundle formation|microtubule nucleation|microtubule organizing center organization|mitotic prometaphase|negative regulation of microtubule depolymerization	centrosomal corona|condensed chromosome kinetochore|cortical microtubule cytoskeleton|cytoplasmic microtubule|cytosol|Golgi apparatus|kinetochore microtubule	kinetochore binding|microtubule plus-end binding			ovary(1)|central_nervous_system(1)	2	Renal(3;0.0496)					AATGGTCTTGAAGTGCTCCTC	0.557000													17	14					0	0	0.00074312	0	0
NFE2L2	4780	broad.mit.edu	37	2	178098800	178098800	+	Missense_Mutation	SNP	T	C	C			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr2:178098800T>C	uc002ulh.3	-	2	800	c.245A>G	c.(244-246)GAA>GGA	p.E82G	NFE2L2_uc002ulg.3_Missense_Mutation_p.E66G|NFE2L2_uc010zfa.1_Missense_Mutation_p.E66G|NFE2L2_uc002uli.3_Missense_Mutation_p.E66G|NFE2L2_uc010fra.2_Missense_Mutation_p.E66G|NFE2L2_uc010frb.2_Missense_Mutation_p.E66G	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	82					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TGGGAGAAATTCACCTGTCTC	0.433000			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			36	49					0	0	0.000953801	0	0
TTN	7273	broad.mit.edu	37	2	179550284	179550284	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr2:179550284G>A	uc010zfg.1	-	125	28845	c.28621C>T	c.(28621-28623)CAC>TAC	p.H9541Y	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.H6202Y|TTN_uc010fre.1_Intron	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	10468							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAAATAATGTGCAGCTTTTCT	0.353000													19	28					0	0	0.00152264	0	0
GTF3C3	9330	broad.mit.edu	37	2	197629315	197629315	+	Missense_Mutation	SNP	G	A	A	rs143599816	byFrequency	TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr2:197629315G>A	uc002uts.2	-	18	2723	c.2633C>T	c.(2632-2634)ACG>ATG	p.T878M	GTF3C3_uc010zgu.1_Missense_Mutation_p.T849M	NM_012086	NP_036218	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide	878						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(3)|breast(3)|pancreas(1)	7						ATACAAAAGCGTTTGAGCCAT	0.448000													38	35					0	0	0.00111076	0	0
FN1	2335	broad.mit.edu	37	2	216289927	216289927	+	Missense_Mutation	SNP	A	C	C			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr2:216289927A>C	uc002vfa.2	-	7	1192	c.926T>G	c.(925-927)GTC>GGC	p.V309G	FN1_uc002vfb.2_Missense_Mutation_p.V309G|FN1_uc002vfc.2_Missense_Mutation_p.V309G|FN1_uc002vfd.2_Missense_Mutation_p.V309G|FN1_uc002vfe.2_Missense_Mutation_p.V309G|FN1_uc002vff.2_Missense_Mutation_p.V309G|FN1_uc002vfg.2_Missense_Mutation_p.V309G|FN1_uc002vfh.2_Missense_Mutation_p.V309G|FN1_uc002vfi.2_Missense_Mutation_p.V309G|FN1_uc002vfj.2_Missense_Mutation_p.V309G|FN1_uc002vfl.2_Missense_Mutation_p.V309G	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	309	Fibronectin type-I 6.|Collagen-binding.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACTGTCTGTGACACAGTGGCC	0.557000													82	114					0	0	0.000781405	0	0
BMP7	655	broad.mit.edu	37	20	55777539	55777539	+	Missense_Mutation	SNP	G	A	A	rs112344257		TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr20:55777539G>A	uc010gip.1	-	3	1281	c.752C>T	c.(751-753)ACG>ATG	p.T251M	BMP7_uc010giq.1_Missense_Mutation_p.T251M|BMP7_uc002xyc.2_Missense_Mutation_p.T251M	NM_001719	NP_001710	P18075	BMP7_HUMAN	bone morphogenetic protein 7 precursor	251					BMP signaling pathway|cartilage development|cellular response to hypoxia|epithelial to mesenchymal transition|growth|mesonephros development|negative regulation of glomerular mesangial cell proliferation|negative regulation of MAP kinase activity|negative regulation of mitosis|negative regulation of neuron differentiation|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of phosphorylation|negative regulation of striated muscle cell apoptosis|negative regulation of transcription, DNA-dependent|ossification|pathway-restricted SMAD protein phosphorylation|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|protein localization to nucleus|regulation of removal of superoxide radicals|SMAD protein signal transduction|steroid hormone mediated signaling pathway|ureteric bud development	extracellular space	cytokine activity|growth factor activity			skin(1)	1	all_lung(29;0.0133)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;2.49e-13)|Epithelial(14;1.74e-08)|all cancers(14;2.05e-07)			ACCATCCAGCGTCTCCACCGA	0.612000													16	5					0	0	0.000308642	0	0
PLAC4	191585	broad.mit.edu	37	21	42551311	42551311	+	Missense_Mutation	SNP	A	G	G			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr21:42551311A>G	uc002yyz.2	-	1	5856	c.245T>C	c.(244-246)ATA>ACA	p.I82T	BACE2_uc002yyw.2_Intron|BACE2_uc002yyx.2_Intron|BACE2_uc002yyy.2_Intron	NM_182832	NP_878252	Q8WY50	PLAC4_HUMAN	placenta-specific 4	82											0		Prostate(19;2.29e-06)				gagtgagggtatccagggtga	0.149000													2	4					0	0	6.4e-05	0	0
GGT3P	2679	broad.mit.edu	37	22	18778675	18778675	+	RNA	SNP	C	T	T	rs141850257	by1000genomes	TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr22:18778675C>T	uc011ago.1	-	2		c.145G>A			GGT3P_uc011agp.1_RNA|GGT3P_uc002zob.1_RNA					Homo sapiens cDNA clone IMAGE:5761295, **** WARNING: chimeric clone ****.												0						AGACAGAGGCCGACAATGACC	0.627000													6	1					0	0	0.000442599	0	0
PDZRN3	23024	broad.mit.edu	37	3	73440201	73440201	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr3:73440201C>T	uc003dpl.1	-	6	1417	c.1321G>A	c.(1321-1323)GAT>AAT	p.D441N	PDZRN3_uc011bgh.1_Missense_Mutation_p.D98N|PDZRN3_uc010hoe.1_Missense_Mutation_p.D139N|PDZRN3_uc011bgf.1_Missense_Mutation_p.D158N|PDZRN3_uc011bgg.1_Missense_Mutation_p.D161N	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	441	PDZ 2.						ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		TCGTCTTCATCGTCCGTCCGG	0.438000													12	297					0	0	0.000219431	0	0
ATP2C1	27032	broad.mit.edu	37	3	130673864	130673864	+	Silent	SNP	C	T	T			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr3:130673864C>T	uc003enl.2	+	10	918	c.696C>T	c.(694-696)GTC>GTT	p.V232V	ATP2C1_uc011blg.1_Silent_p.V266V|ATP2C1_uc011blh.1_Silent_p.V227V|ATP2C1_uc011bli.1_Silent_p.V266V|ATP2C1_uc003enk.2_Silent_p.V216V|ATP2C1_uc003enm.2_Silent_p.V232V|ATP2C1_uc003enn.2_Silent_p.V216V|ATP2C1_uc003eno.2_Silent_p.V232V|ATP2C1_uc003enp.2_Silent_p.V232V|ATP2C1_uc003enq.2_Silent_p.V232V|ATP2C1_uc003enr.2_Silent_p.V232V|ATP2C1_uc003ens.2_Silent_p.V232V|ATP2C1_uc003ent.2_Silent_p.V232V	NM_014382	NP_055197	P98194	AT2C1_HUMAN	calcium-transporting ATPase 2C1 isoform 1a	232	Cytoplasmic (By similarity).				actin cytoskeleton reorganization|ATP biosynthetic process|calcium-dependent cell-cell adhesion|cellular calcium ion homeostasis|cellular manganese ion homeostasis|epidermis development|Golgi calcium ion homeostasis|Golgi calcium ion transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi apparatus|Golgi membrane|integral to membrane|trans-Golgi network	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|manganese ion binding|manganese-transporting ATPase activity|metal ion binding|signal transducer activity			skin(1)	1					Arsenic trioxide(DB01169)|Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Miconazole(DB01110)|Sevoflurane(DB01236)	AGGGTGTTGTCATTGGAACAG	0.343000									Hailey-Hailey_disease				13	30					0	0	0.000308642	0	0
AFAP1	60312	broad.mit.edu	37	4	7857226	7857226	+	Missense_Mutation	SNP	T	G	G			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr4:7857226T>G	uc003gkg.1	-	4	574	c.301A>C	c.(301-303)AGC>CGC	p.S101R	AFAP1_uc011bwk.1_Missense_Mutation_p.S101R	NM_198595	NP_940997	Q8N556	AFAP1_HUMAN	actin filament associated protein 1	101	Pro-rich.					actin cytoskeleton|cytoplasm|focal adhesion	actin binding				0						TTTCCGGGGCTCAGCGGCACA	0.562000													21	28					0	0	0.000375601	0	0
SMARCAD1	56916	broad.mit.edu	37	4	95191935	95191935	+	Missense_Mutation	SNP	A	G	G			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr4:95191935A>G	uc003htc.3	+	11	1793	c.1538A>G	c.(1537-1539)AAA>AGA	p.K513R	SMARCAD1_uc003htb.3_Missense_Mutation_p.K513R|SMARCAD1_uc003htd.3_Missense_Mutation_p.K513R|SMARCAD1_uc010ila.2_Missense_Mutation_p.K376R|SMARCAD1_uc011cdw.1_Missense_Mutation_p.K83R	NM_020159	NP_064544	Q9H4L7	SMRCD_HUMAN	SWI/SNF-related, matrix-associated	513	Helicase ATP-binding.				chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			skin(2)|ovary(1)|breast(1)	4				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)		TTGGTACATAAACATGGACTT	0.343000													36	59					0	0	0.00148497	0	0
PDZD2	23037	broad.mit.edu	37	5	32108145	32108145	+	Silent	SNP	G	A	A			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr5:32108145G>A	uc003jhl.2	+	25	8812	c.8424G>A	c.(8422-8424)CTG>CTA	p.L2808L	PDZD2_uc003jhm.2_Silent_p.L2808L|PDZD2_uc003jhn.2_RNA|PDZD2_uc003jho.2_RNA	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	2808	PDZ 6.				cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						GGAAACCTCTGGTTGGGCTCA	0.388000													47	59					0	0	0.000781405	0	0
POLK	51426	broad.mit.edu	37	5	74872636	74872636	+	Missense_Mutation	SNP	A	C	C			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr5:74872636A>C	uc003kdw.2	+	6	668	c.572A>C	c.(571-573)AAT>ACT	p.N191T	POLK_uc003kdx.2_RNA|POLK_uc003kdy.2_RNA|POLK_uc003kea.2_Missense_Mutation_p.N191T|POLK_uc003keb.2_Missense_Mutation_p.N191T|POLK_uc010izq.2_Missense_Mutation_p.N191T|POLK_uc003kec.2_Missense_Mutation_p.N101T|POLK_uc010izr.2_RNA|POLK_uc010izs.2_RNA|POLK_uc003ked.2_Missense_Mutation_p.N101T|POLK_uc003kee.2_Missense_Mutation_p.N191T|POLK_uc003kef.2_Missense_Mutation_p.N101T	NM_016218	NP_057302	Q9UBT6	POLK_HUMAN	DNA-directed DNA polymerase kappa	191	UmuC.				DNA replication|nucleotide-excision repair, DNA gap filling	nucleus	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			ovary(2)|kidney(2)	4		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;2.9e-54)|all cancers(79;1.27e-42)		TATGATCCCAATTTTATGGCC	0.328000								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					20	27					0	0	0.00188189	0	0
ZNF608	57507	broad.mit.edu	37	5	123983889	123983889	+	Missense_Mutation	SNP	A	T	T			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr5:123983889A>T	uc003ktq.1	-	4	2311	c.2188T>A	c.(2188-2190)TCT>ACT	p.S730T	ZNF608_uc003ktr.1_Intron|ZNF608_uc003kts.1_Missense_Mutation_p.S730T|ZNF608_uc003ktt.1_Missense_Mutation_p.S730T	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	730						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		TTCAGTTTAGAGAGGTTTTTG	0.483000													21	23					0	0	0.00121646	0	0
MAML1	9794	broad.mit.edu	37	5	179192887	179192887	+	Silent	SNP	G	A	A			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr5:179192887G>A	uc003mkm.2	+	2	1139	c.876G>A	c.(874-876)TTG>TTA	p.L292L	MAML1_uc003mkn.1_Silent_p.L292L	NM_014757	NP_055572	Q92585	MAML1_HUMAN	mastermind-like 1	292					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	peptide antigen binding|protein kinase binding|transcription coactivator activity			lung(4)|ovary(2)	6	all_cancers(89;0.000197)|all_epithelial(37;6.7e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0308)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AAACCCCCTTGGCACAGGACA	0.527000													53	66					0	0	0.000781405	0	0
BAT2	7916	broad.mit.edu	37	6	31595867	31595867	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr6:31595867C>T	uc003nvb.3	+	12	1865	c.1616C>T	c.(1615-1617)GCC>GTC	p.A539V	BAT2_uc011dnv.1_Intron|BAT2_uc003nvc.3_Missense_Mutation_p.A539V	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	539	4 X 57 AA type A repeats.|2 X type B repeats.|2-2.					cytoplasm|nucleus	protein binding				0						CCAGCATCAGCCCCAACACCA	0.627000													44	71					0	0	0.000781405	0	0
C6orf226	441150	broad.mit.edu	37	6	42858492	42858492	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr6:42858492G>A	uc003osw.2	-	1	63	c.35C>T	c.(34-36)CCG>CTG	p.P12L		NM_001008739	NP_001008739	Q5I0X4	CF226_HUMAN	hypothetical protein LOC441150	12											0						GGCAGAGGCCGGGGCCGAGCA	0.672000													24	45					0	0	0.000586117	0	0
PKHD1	5314	broad.mit.edu	37	6	51917922	51917922	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr6:51917922C>T	uc003pah.1	-	21	2368	c.2092G>A	c.(2092-2094)GGC>AGC	p.G698S	PKHD1_uc003pai.2_Missense_Mutation_p.G698S	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	698	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					TAGAACAGGCCCGTCTCCTGG	0.517000													19	32					0	0	0.00188189	0	0
CLIP2	7461	broad.mit.edu	37	7	73752800	73752800	+	Silent	SNP	A	T	T			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr7:73752800A>T	uc003uam.2	+	3	471	c.144A>T	c.(142-144)TCA>TCT	p.S48S	CLIP2_uc003uan.2_Silent_p.S48S	NM_003388	NP_003379	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	48						microtubule associated complex				skin(3)	3						ACAAACAGTCATCTGGACCCT	0.657000													12	8					0	0	0.000308642	0	0
CHCHD3	54927	broad.mit.edu	37	7	132754922	132754922	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr7:132754922G>A	uc003vre.2	-	2	285	c.149C>T	c.(148-150)TCT>TTT	p.S50F	CHCHD3_uc010lmi.2_RNA|CHCHD3_uc003vrf.2_Missense_Mutation_p.S50F|CHCHD3_uc010lmj.2_Intron|CHCHD3_uc011kpn.1_Missense_Mutation_p.S50F	NM_017812	NP_060282	Q9NX63	CHCH3_HUMAN	coiled-coil-helix-coiled-coil-helix domain	50					inner mitochondrial membrane organization|mitochondrial fusion	mitochondrial inner membrane	protein complex scaffold				0						ATAAGCACCAGAATACCGCTG	0.353000													12	48					0	0	0.000308642	0	0
EXOC4	60412	broad.mit.edu	37	7	133692515	133692515	+	Missense_Mutation	SNP	A	G	G			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr7:133692515A>G	uc003vrk.2	+	17	2649	c.2614A>G	c.(2614-2616)AGG>GGG	p.R872G	EXOC4_uc011kpo.1_Missense_Mutation_p.R771G|EXOC4_uc003vrl.2_Missense_Mutation_p.R482G|EXOC4_uc011kpp.1_Missense_Mutation_p.R404G|EXOC4_uc011kpq.1_Missense_Mutation_p.R160G	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a	872					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				GAAAATGTGTAGGAACATTTT	0.502000													29	45					0	0	0.00178596	0	0
KIAA1549	57670	broad.mit.edu	37	7	138595898	138595898	+	Missense_Mutation	SNP	G	T	T			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr7:138595898G>T	uc011kql.1	-	4	3188	c.3139C>A	c.(3139-3141)CAA>AAA	p.Q1047K	KIAA1549_uc003vuk.3_Missense_Mutation_p.Q997K|KIAA1549_uc011kqj.1_Missense_Mutation_p.Q1047K	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	1047						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						TCACCTGTTTGAACTTGGAAC	0.328000			O	BRAF	pilocytic astrocytoma								7	16					0.000274275	0.0057721	0.000274275	1	0
MGAM	8972	broad.mit.edu	37	7	141750617	141750617	+	Missense_Mutation	SNP	G	T	T			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr7:141750617G>T	uc003vwy.2	+	24	2812	c.2758G>T	c.(2758-2760)GTC>TTC	p.V920F		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	920	Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	ACACAATGGTGTCCCAAGTCA	0.388000													33	119					1.22384e-17	2.63476e-16	0.000491102	1	0
OR2F1	26211	broad.mit.edu	37	7	143657509	143657509	+	Missense_Mutation	SNP	G	T	T			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr7:143657509G>T	uc003wds.1	+	1	490	c.446G>T	c.(445-447)TGG>TTG	p.W149L		NM_012369	NP_036501	Q13607	OR2F1_HUMAN	olfactory receptor, family 2, subfamily F,	149	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.W149C(1)		skin(2)|ovary(1)	3	Melanoma(164;0.0903)					ATCACATCCTGGGTCAGTGGC	0.527000													79	47					9.35349e-44	2.08561e-42	0.000781405	1	0
PTPRN2	5799	broad.mit.edu	37	7	157414139	157414139	+	Silent	SNP	G	A	A	rs77143062	by1000genomes	TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr7:157414139G>A	uc003wno.2	-	15	2380	c.2259C>T	c.(2257-2259)TGC>TGT	p.C753C	PTPRN2_uc003wnp.2_Silent_p.C736C|PTPRN2_uc003wnq.2_Silent_p.C724C|PTPRN2_uc003wnr.2_Silent_p.C715C|PTPRN2_uc011kwa.1_Silent_p.C776C	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	753	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		CCTGGTAGGCGCACAGCGCTT	0.622000													14	318					0	0	0.000219431	0	0
LZTS1	11178	broad.mit.edu	37	8	20107305	20107305	+	Silent	SNP	G	A	A			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr8:20107305G>A	uc003wzr.2	-	3	1830	c.1719C>T	c.(1717-1719)GCC>GCT	p.A573A	LZTS1_uc010ltg.1_Silent_p.A514A	NM_021020	NP_066300	Q9Y250	LZTS1_HUMAN	leucine zipper, putative tumor suppressor 1	573					cell cycle|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	cell junction|dendritic spine|Golgi apparatus|nucleolus|nucleoplasm|postsynaptic density|postsynaptic membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				Colorectal(74;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		AGGGCTCCCCGGCGCTGTCCC	0.632000													48	55					0	0	0.000781405	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110451259	110451259	+	Silent	SNP	G	A	A			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr8:110451259G>A	uc003yne.2	+	32	3998	c.3894G>A	c.(3892-3894)AAG>AAA	p.K1298K		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1298	Extracellular (Potential).|IPT/TIG 6.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTTTGCCCAAGTTGTCTCCTG	0.393000										HNSCC(38;0.096)			65	97					0	0	0.000781405	0	0
RGS3	5998	broad.mit.edu	37	9	116269730	116269730	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr9:116269730C>T	uc004bhq.2	+	14	1458	c.1249C>T	c.(1249-1251)CGG>TGG	p.R417W	RGS3_uc004bhr.2_Missense_Mutation_p.R305W|RGS3_uc004bhs.2_Missense_Mutation_p.R307W|RGS3_uc004bht.2_Missense_Mutation_p.R136W|RGS3_uc010muy.2_Missense_Mutation_p.R136W|RGS3_uc004bhu.2_Missense_Mutation_p.R43W	NM_144488	NP_652759	P49796	RGS3_HUMAN	regulator of G-protein signalling 3 isoform 6	417					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3						GGTCCAGGCACGGCCTGAGCA	0.672000													17	24					0	0	0.000566183	0	0
RBMY1A3P	286557	broad.mit.edu	37	Y	9160442	9160442	+	RNA	SNP	A	C	C			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chrY:9160442A>C	uc004frl.1	-	1		c.42T>G				NR_001547				Homo sapiens RBMY1A3P pseudogene, mRNA sequence.												0						TTGAGGCCACAAATGAAAAGC	0.313000													2	6					0	0	6.4e-05	0	0
LNX2	222484	broad.mit.edu	37	13	28136573	28136575	+	In_Frame_Del	DEL	CCG	-	-			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr13:28136573_28136575delCCG	uc001url.3	-	5	1508_1510	c.1199_1201delCGG	c.(1198-1203)CCGGAG>CAG	p.400_401PE>Q	LNX2_uc001urm.1_In_Frame_Del_p.400_401PE>Q	NM_153371	NP_699202	Q8N448	LNX2_HUMAN	ligand of numb-protein X 2	400_401	PDZ 2.						zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)|central_nervous_system(1)	6		Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.113)|all cancers(112;0.127)|Epithelial(112;0.248)		GCAGCAAGCTCCGGAGTTCCATA	0.512													58	87	---	---	---	---					
ITPKA	3706	broad.mit.edu	37	15	41794669	41794670	+	Frame_Shift_Ins	INS	-	A	A			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr15:41794669_41794670insA	uc001znz.2	+	5	1089_1090	c.1078_1079insA	c.(1078-1080)GAAfs	p.E360fs		NM_002220	NP_002211	P23677	IP3KA_HUMAN	1D-myo-inositol-trisphosphate 3-kinase A	360					signal transduction		ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity				0		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;7.63e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		TCGCGTCTTTGAAGAGTTTGTG	0.604													29	49	---	---	---	---					
C15orf43	145645	broad.mit.edu	37	15	45270783	45270783	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr15:45270783delA	uc001zuk.2	+	7	637	c.620delA	c.(619-621)GAAfs	p.E207fs		NM_152448	NP_689661	Q8NHR7	CO043_HUMAN	hypothetical protein LOC145645	207											0		all_cancers(109;3.68e-08)|all_epithelial(112;1.05e-06)|Lung NSC(122;1.42e-05)|all_lung(180;0.000112)|Melanoma(134;0.0192)		all cancers(107;7.64e-17)|GBM - Glioblastoma multiforme(94;2.03e-06)		GTTCAAAATGAAATTAATATG	0.294													18	27	---	---	---	---					
NF1	4763	broad.mit.edu	37	17	29490388	29490388	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr17:29490388delC	uc002hgg.2	+	4	806	c.473delC	c.(472-474)TCTfs	p.S158fs	NF1_uc002hge.1_Frame_Shift_Del_p.S158fs|NF1_uc002hgf.1_Frame_Shift_Del_p.S158fs|NF1_uc002hgh.2_Frame_Shift_Del_p.S158fs|NF1_uc010csn.1_Frame_Shift_Del_p.L54fs	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	158					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(5)|p.?(4)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		AGTCGCATTTCTACCAGGTTA	0.368			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			56	48	---	---	---	---					
NF1	4763	broad.mit.edu	37	17	29552188	29552189	+	Frame_Shift_Del	DEL	AG	-	-			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr17:29552188_29552189delAG	uc002hgg.2	+	17	2254_2255	c.1921_1922delAG	c.(1921-1923)AGTfs	p.S641fs	NF1_uc002hgh.2_Frame_Shift_Del_p.S641fs|NF1_uc010csn.1_Frame_Shift_Del_p.S501fs|NF1_uc002hgi.1_5'UTR	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	641					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TGGAAATACCAGTCAAATGTCC	0.406			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			70	107	---	---	---	---					
C19orf45	374877	broad.mit.edu	37	19	7570473	7570475	+	In_Frame_Del	DEL	CGG	-	-			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr19:7570473_7570475delCGG	uc002mgm.2	+	6	1107_1109	c.966_968delCGG	c.(964-969)CCCGGC>CCC	p.G323del	C19orf45_uc010xjo.1_5'UTR	NM_198534	NP_940936	Q8NA69	CS045_HUMAN	hypothetical protein LOC374877	323											0						GCCCCGGCCCCGGCAGTCTGGAC	0.394													25	46	---	---	---	---					
PARD6B	84612	broad.mit.edu	37	20	49366983	49366991	+	In_Frame_Del	DEL	TCAAAAACT	-	-			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr20:49366983_49366991delTCAAAAACT	uc002xvo.2	+	3	1320_1328	c.1077_1085delTCAAAAACT	c.(1075-1086)GATCAAAAACTC>GAC	p.QKL360del		NM_032521	NP_115910	Q9BYG5	PAR6B_HUMAN	PAR-6 beta	360_362					axonogenesis|cell cycle|cell division|establishment or maintenance of cell polarity|protein complex assembly|regulation of cell migration|tight junction assembly	cytosol|tight junction	protein binding			kidney(1)	1						ATGCTCCAGATCAAAAACTCTTAGAAGAA	0.397													22	52	---	---	---	---					
PLAC4	191585	broad.mit.edu	37	21	42551313	42551313	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr21:42551313delC	uc002yyz.2	-	1	5854	c.243delG	c.(241-243)TGGfs	p.W81fs	BACE2_uc002yyw.2_Intron|BACE2_uc002yyx.2_Intron|BACE2_uc002yyy.2_Intron	NM_182832	NP_878252	Q8WY50	PLAC4_HUMAN	placenta-specific 4	81											0		Prostate(19;2.29e-06)				gtgagggtatccagggtgagt	0.159													2	4	---	---	---	---					
SLC10A4	201780	broad.mit.edu	37	4	48490947	48490948	+	Frame_Shift_Ins	INS	-	TC	TC			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr4:48490947_48490948insTC	uc003gyc.2	+	3	1524_1525	c.1305_1306insTC	c.(1303-1308)ACTTCTfs	p.T435fs	ZAR1_uc003gyd.2_5'Flank	NM_152679	NP_689892	Q96EP9	NTCP4_HUMAN	solute carrier family 10, member 4	435_436	Extracellular (Potential).					integral to membrane	bile acid:sodium symporter activity			central_nervous_system(1)	1						CCGCTCAGACTTCTCTCTAAAT	0.351													16	51	---	---	---	---					
UFSP1	402682	broad.mit.edu	37	7	100486530	100486530	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr7:100486530delG	uc003uxc.3	-	1	810	c.363delC	c.(361-363)CCCfs	p.P121fs	uc010lhm.1_5'Flank	NM_001015072	NP_001015072	Q6NVU6	UFSP1_HUMAN	inactive Ufm1-specific protease 1	121											0	Lung NSC(181;0.041)|all_lung(186;0.0581)					AGAAGGAGTTGGGGTCAAAGG	0.567													106	93	---	---	---	---					
PPP2R2A	5520	broad.mit.edu	37	8	26227846	26227849	+	Frame_Shift_Del	DEL	CACA	-	-			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr8:26227846_26227849delCACA	uc003xeu.2	+	10	1563_1566	c.1261_1264delCACA	c.(1261-1266)CACACAfs	p.H421fs	PPP2R2A_uc003xek.2_Frame_Shift_Del_p.H422fs|PPP2R2A_uc011laf.1_Frame_Shift_Del_p.H431fs	NM_002717	NP_002708	P63151	2ABA_HUMAN	alpha isoform of regulatory subunit B55, protein	421_422	WD 7.				protein dephosphorylation|signal transduction	protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity|protein serine/threonine phosphatase activity			ovary(1)|kidney(1)	2		all_cancers(63;0.086)|Ovarian(32;2.61e-05)|all_epithelial(46;0.0514)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.000754)|Epithelial(17;3.02e-15)|all cancers(2;1.52e-13)|OV - Ovarian serous cystadenocarcinoma(2;1.89e-10)|Colorectal(74;0.155)		GAAAATCCTTCACACAGCCTGGCA	0.426													11	34	---	---	---	---					
MYST3	7994	broad.mit.edu	37	8	41798420	41798422	+	In_Frame_Del	DEL	CTC	-	-			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chr8:41798420_41798422delCTC	uc010lxb.2	-	16	3521_3523	c.2977_2979delGAG	c.(2977-2979)GAGdel	p.E993del	MYST3_uc010lxc.2_In_Frame_Del_p.E993del|MYST3_uc003xon.3_In_Frame_Del_p.E993del	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	993	Poly-Glu.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			GGCTTTCCGGCTCCTCCTCCTCC	0.567													7	190	---	---	---	---					
PORCN	64840	broad.mit.edu	37	X	48371012	48371012	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BQ-7044-01A-11D-1961-08	TCGA-BQ-7044-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0589e51-4685-4613-8004-44efad45180f	12341a8c-b9d0-445d-b2fd-ed077738ba31	g.chrX:48371012delG	uc010nie.1	+	6	749	c.591delG	c.(589-591)CTGfs	p.L197fs	PORCN_uc004djr.1_Frame_Shift_Del_p.L197fs|PORCN_uc004djs.1_Frame_Shift_Del_p.L197fs|PORCN_uc004djt.1_Frame_Shift_Del_p.L126fs|PORCN_uc011mlx.1_Frame_Shift_Del_p.L126fs|PORCN_uc004dju.1_Frame_Shift_Del_p.L66fs|PORCN_uc004djv.1_Frame_Shift_Del_p.L197fs|PORCN_uc004djw.1_Frame_Shift_Del_p.L197fs	NM_203475	NP_982301	Q9H237	PORCN_HUMAN	porcupine isoform D	197	Cytoplasmic (Potential).				Wnt receptor signaling pathway	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			ovary(2)|central_nervous_system(1)	3						CCCGGAGCCTGGCACTGGCCC	0.647													11	0	---	---	---	---					
