Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MTOR	2475	broad.mit.edu	37	1	11307790	11307790	+	Missense_Mutation	SNP	C	A	A			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr1:11307790C>A	uc001asd.2	-	8	1238	c.1117G>T	c.(1117-1119)GTG>TTG	p.V373L		NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	373					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						CACTGGCACACCTGAGAGAGG	0.498000													16	59					1.15088e-07	3.64634e-07	0.004007	1	0
ZMYM6	9204	broad.mit.edu	37	1	35476600	35476600	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr1:35476600G>A	uc001byh.2	-	9	1328	c.1100C>T	c.(1099-1101)GCG>GTG	p.A367V	ZMYM6_uc001byf.1_Missense_Mutation_p.A367V|ZMYM6_uc010oht.1_Missense_Mutation_p.A270V|ZMYM6_uc009vup.2_Missense_Mutation_p.A173V|ZMYM6_uc009vuq.1_Missense_Mutation_p.A367V|ZMYM6_uc009vur.1_Missense_Mutation_p.A173V	NM_007167	NP_009098	O95789	ZMYM6_HUMAN	zinc finger protein 258	367	MYM-type 5.				multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				CAGGGGCACCGCCGAAGAGTT	0.458000													30	42					0	0	0.002836	0	0
GLMN	11146	broad.mit.edu	37	1	92712096	92712096	+	Silent	SNP	C	G	G			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr1:92712096C>G	uc001dor.2	-	19	1891	c.1776G>C	c.(1774-1776)GGG>GGC	p.G592G	GLMN_uc009wdg.2_RNA|GLMN_uc001dos.2_Silent_p.G578G	NM_053274	NP_444504	Q92990	GLMN_HUMAN	glomulin	592					muscle cell differentiation|negative regulation of T cell proliferation|positive regulation of cytokine secretion|positive regulation of interleukin-2 biosynthetic process|positive regulation of phosphorylation|regulation of gene expression, epigenetic|vasculogenesis	intracellular	hepatocyte growth factor receptor binding			skin(1)	1		all_lung(203;0.00827)|Lung NSC(277;0.0295)		all cancers(265;0.00702)|GBM - Glioblastoma multiforme(16;0.0381)|Epithelial(280;0.0989)		TTCACTTTATCCCAATATTTT	0.259000									Multiple_Glomus_Tumors_(of_the_Skin)_Familial				3	27					0	0	0.004672	0	0
LCE2A	353139	broad.mit.edu	37	1	152671691	152671691	+	Missense_Mutation	SNP	G	C	C			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr1:152671691G>C	uc001faj.2	+	2	365	c.314G>C	c.(313-315)TGC>TCC	p.C105S		NM_178428	NP_848515	Q5TA79	LCE2A_HUMAN	late cornified envelope 2A	105	Cys-rich.				keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCTGGGGACTGCTGCTGACCA	0.587000													21	70					0	0	0.003954	0	0
DHX9	1660	broad.mit.edu	37	1	182850707	182850707	+	Missense_Mutation	SNP	A	G	G			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr1:182850707A>G	uc001gpr.2	+	24	3002	c.2839A>G	c.(2839-2841)ATG>GTG	p.M947V	DHX9_uc001gps.2_Missense_Mutation_p.M733V|DHX9_uc001gpt.2_Missense_Mutation_p.M226V|DHX9_uc009wyd.2_Translation_Start_Site	NM_001357	NP_001348	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 9	947					CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			ovary(2)	2						AAGACTTAATATGGCTACACT	0.363000													66	26					0	0	0.003610	0	0
ABCC2	1244	broad.mit.edu	37	10	101569944	101569944	+	Silent	SNP	C	T	T			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr10:101569944C>T	uc001kqf.2	+	14	2008	c.1869C>T	c.(1867-1869)GAC>GAT	p.D623D		NM_000392	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP),	623	Cytoplasmic (By similarity).					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	ATGACTTGGACACATCTGCCA	0.368000													16	27					0	0	0.004990	0	0
GBF1	8729	broad.mit.edu	37	10	104112265	104112265	+	Missense_Mutation	SNP	C	G	G			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr10:104112265C>G	uc001kux.1	+	7	814	c.574C>G	c.(574-576)CTC>GTC	p.L192V	GBF1_uc001kuw.2_Missense_Mutation_p.L192V|GBF1_uc001kuy.1_Missense_Mutation_p.L192V|GBF1_uc001kuz.1_Missense_Mutation_p.L192V	NM_004193	NP_004184	Q92538	GBF1_HUMAN	golgi-specific brefeldin A resistant guanine	192					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		GGTGCAGCTGCTCTTCACAAG	0.522000											OREG0020477	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	43					0	0	0.006320	0	0
GRM5	2915	broad.mit.edu	37	11	88242044	88242044	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr11:88242044G>A	uc001pcq.2	-	9	3555	c.3355C>T	c.(3355-3357)CCG>TCG	p.P1119S	GRM5_uc009yvm.2_Missense_Mutation_p.P1087S	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	1119	Cytoplasmic (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	TCGATGGCCGGCAGAGGCTGG	0.736000													4	11					0	0	0.001984	0	0
MMP27	64066	broad.mit.edu	37	11	102567479	102567479	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr11:102567479G>A	uc001phd.1	-	5	730	c.707C>T	c.(706-708)CCA>CTA	p.P236L		NM_022122	NP_071405	Q9H306	MMP27_HUMAN	matrix metalloproteinase 27 precursor	236					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3	all_cancers(8;0.000843)|all_epithelial(12;0.00362)|Lung NSC(15;0.21)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0509)|Lung(13;0.0696)|LUSC - Lung squamous cell carcinoma(19;0.13)|all cancers(10;0.176)	BRCA - Breast invasive adenocarcinoma(274;0.0151)		GACATAATTTGGGAACATCAA	0.398000													4	34					0	0	0.001168	0	0
POU2AF1	5450	broad.mit.edu	37	11	111225200	111225200	+	Missense_Mutation	SNP	A	G	G			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr11:111225200A>G	uc001plg.3	-	5	812	c.557T>C	c.(556-558)CTA>CCA	p.L186P		NM_006235	NP_006226	Q16633	OBF1_HUMAN	POU class 2 associating factor 1	186					humoral immune response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			kidney(1)	1		all_cancers(61;1.36e-12)|all_epithelial(67;1.87e-07)|Melanoma(852;1.46e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|all_neural(223;0.0146)|Medulloblastoma(222;0.0245)|Breast(348;0.0389)		Epithelial(105;1.01e-06)|BRCA - Breast invasive adenocarcinoma(274;3.12e-06)|all cancers(92;1.8e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0364)		GGAGGTGGGTAGTGTGGAAAG	0.667000			T	BCL6	NHL								24	39					0	0	0.002780	0	0
SLC6A13	6540	broad.mit.edu	37	12	346409	346409	+	Missense_Mutation	SNP	A	T	T			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr12:346409A>T	uc001qic.1	-	6	664	c.611T>A	c.(610-612)CTG>CAG	p.L204Q	SLC6A13_uc009zdj.1_Missense_Mutation_p.L204Q|SLC6A13_uc010sdl.1_Missense_Mutation_p.L112Q|SLC6A13_uc010sdm.1_Missense_Mutation_p.L85Q	NM_016615	NP_057699	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter	204	Extracellular (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			CTCCCAGCGCAGGGCCCCCAG	0.602000													30	104					0	0	0.004289	0	0
ATN1	1822	broad.mit.edu	37	12	7046365	7046365	+	Silent	SNP	C	G	G			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr12:7046365C>G	uc001qrw.1	+	5	2172	c.1935C>G	c.(1933-1935)TCC>TCG	p.S645S	ATN1_uc001qrx.1_Silent_p.S645S	NM_001007026	NP_001007027	P54259	ATN1_HUMAN	atrophin-1	645					cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						GAGCCCCGTCCCCGGGGGCCT	0.672000													45	34					0	0	0.003610	0	0
TAS2R13	50838	broad.mit.edu	37	12	11061866	11061866	+	Missense_Mutation	SNP	A	C	C			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr12:11061866A>C	uc001qzg.1	-	1	296	c.32T>G	c.(31-33)CTT>CGT	p.L11R	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron	NM_023920	NP_076409	Q9NYV9	T2R13_HUMAN	taste receptor, type 2, member 13	11	Helical; Name=1; (Potential).				sensory perception of taste	integral to membrane	taste receptor activity			breast(1)|skin(1)	2						AATTATTACAAGAGTGAAGAT	0.388000													29	18					0	0	0.007291	0	0
GPR182	11318	broad.mit.edu	37	12	57389326	57389326	+	Silent	SNP	G	A	A			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr12:57389326G>A	uc001smk.2	+	2	427	c.333G>A	c.(331-333)CTG>CTA	p.L111L	RDH16_uc010sqx.1_Intron	NM_007264	NP_009195	O15218	GP182_HUMAN	G protein-coupled receptor 182	111	Helical; Name=2; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(1)	1						TGTGGATGCTGGAGGTCACGC	0.582000													5	102					0	0	0.000602	0	0
RFX4	5992	broad.mit.edu	37	12	107154995	107154995	+	Silent	SNP	T	A	A			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr12:107154995T>A	uc001tlr.2	+	18	2022	c.1956T>A	c.(1954-1956)ACT>ACA	p.T652T	RFX4_uc001tlt.2_Silent_p.T661T|RFX4_uc001tlv.2_Silent_p.T558T	NM_213594	NP_998759	Q33E94	RFX4_HUMAN	regulatory factor X4 isoform c	652					transcription, DNA-dependent	nucleus	DNA binding			upper_aerodigestive_tract(1)	1						ATAGCCCCACTTCCCGGATGG	0.468000													242	200					0	0	0.003610	0	0
NOS1	4842	broad.mit.edu	37	12	117655909	117655909	+	Missense_Mutation	SNP	T	C	C			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr12:117655909T>C	uc001twm.1	-	28	4917	c.4231A>G	c.(4231-4233)AAC>GAC	p.N1411D		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	1411					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	CTAAGGCGGTTGGTCACTTCG	0.498000													110	372					0	0	0.003610	0	0
RIMBP2	23504	broad.mit.edu	37	12	130919339	130919339	+	Silent	SNP	G	A	A			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr12:130919339G>A	uc001uil.2	-	11	2306	c.2142C>T	c.(2140-2142)GAC>GAT	p.D714D	RIMBP2_uc001uim.2_Silent_p.D622D|RIMBP2_uc001uin.1_Silent_p.D373D	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	714						cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		TCCTCTTGAAGTCTGGAGAGT	0.597000													29	158					0	0	0.006320	0	0
TEP1	7011	broad.mit.edu	37	14	20869208	20869208	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr14:20869208G>A	uc001vxe.2	-	9	1524	c.1484C>T	c.(1483-1485)CCA>CTA	p.P495L	TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Missense_Mutation_p.P387L	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	495	TROVE.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		CCAGGTCTCTGGCCTAGACAG	0.557000													35	72					0	0	0.003755	0	0
ADAM6	8755	broad.mit.edu	37	14	107198935	107198935	+	RNA	SNP	A	C	C			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr14:107198935A>C	uc010tyt.1	-	21		c.1763T>G								Parts of antibodies, mostly variable regions.												0						CTGTGTCTCTAGCACAGTAAT	0.567000													66	97					0	0	0.003610	0	0
TP53BP1	7158	broad.mit.edu	37	15	43749140	43749140	+	Missense_Mutation	SNP	T	A	A			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr15:43749140T>A	uc001zrs.2	-	12	1799	c.1651A>T	c.(1651-1653)ATG>TTG	p.M551L	TP53BP1_uc010udp.1_Missense_Mutation_p.M551L|TP53BP1_uc001zrq.3_Missense_Mutation_p.M556L|TP53BP1_uc001zrr.3_Missense_Mutation_p.M556L|TP53BP1_uc010udq.1_Missense_Mutation_p.M556L	NM_005657	NP_005648	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1 isoform 3	551					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		ACTGGAGACATGGGTTCCGTA	0.403000								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					25	33					0	0	0.003330	0	0
MYO1E	4643	broad.mit.edu	37	15	59501015	59501015	+	Silent	SNP	G	A	A			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr15:59501015G>A	uc002aga.2	-	14	1767	c.1395C>T	c.(1393-1395)GAC>GAT	p.D465D		NM_004998	NP_004989	Q12965	MYO1E_HUMAN	myosin IE	465	Myosin head-like.				actin filament-based movement	myosin complex	actin binding|ATP binding|ATPase activity, coupled|calmodulin binding|microfilament motor activity			central_nervous_system(3)	3				all cancers(107;0.207)		TGGCGCACACGTCATCCAGGA	0.542000													12	52					0	0	0.001855	0	0
TLN2	83660	broad.mit.edu	37	15	63011987	63011987	+	Missense_Mutation	SNP	C	G	G			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr15:63011987C>G	uc002alb.3	+	22	2899	c.2899C>G	c.(2899-2901)CAG>GAG	p.Q967E		NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	967	Ala-rich.				cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						TCACATCCCTCAGCTGGTCCA	0.547000													12	20					0	0	0.001368	0	0
RASGRF1	5923	broad.mit.edu	37	15	79264261	79264261	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr15:79264261G>A	uc002beq.2	-	27	4051	c.3676C>T	c.(3676-3678)CGA>TGA	p.R1226*	RASGRF1_uc002bep.2_Nonsense_Mutation_p.R1210*|RASGRF1_uc002beo.2_Nonsense_Mutation_p.R442*	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Ras protein-specific guanine	1228	Ras-GEF.				activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			skin(4)|ovary(1)|central_nervous_system(1)	6						CGAATCTCTCGGATAATATGG	0.473000													56	111					0	0	0.003610	0	0
KIAA1024	23251	broad.mit.edu	37	15	79748657	79748657	+	Silent	SNP	C	T	T			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr15:79748657C>T	uc002bew.1	+	2	243	c.168C>T	c.(166-168)CTC>CTT	p.L56L	KIAA1024_uc010unk.1_Silent_p.L56L	NM_015206	NP_056021	Q9UPX6	K1024_HUMAN	hypothetical protein LOC23251	56						integral to membrane				pancreas(2)|ovary(1)|central_nervous_system(1)	4						CAGCTTGTCTCGATCCCAATT	0.458000													6	106					0	0	0.001168	0	0
ROGDI	79641	broad.mit.edu	37	16	4849743	4849743	+	Missense_Mutation	SNP	G	C	C			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr16:4849743G>C	uc002cxv.2	-	6	478	c.376C>G	c.(376-378)CTG>GTG	p.L126V	ROGDI_uc002cxu.2_Missense_Mutation_p.L36V|ROGDI_uc010bua.2_RNA|ROGDI_uc002cxw.2_Missense_Mutation_p.L36V	NM_024589	NP_078865	Q9GZN7	ROGDI_HUMAN	leucine zipper domain protein	126						intracellular				ovary(1)|skin(1)	2						CTGGTAAGCAGGTAAATGGCT	0.622000													3	12					0	0	0.000248	0	0
MYH11	4629	broad.mit.edu	37	16	15841744	15841744	+	Missense_Mutation	SNP	G	T	T			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr16:15841744G>T	uc002ddy.2	-	18	2344	c.2237C>A	c.(2236-2238)GCC>GAC	p.A746D	MYH11_uc002ddv.2_Missense_Mutation_p.A753D|MYH11_uc002ddw.2_Missense_Mutation_p.A746D|MYH11_uc002ddx.2_Missense_Mutation_p.A753D|MYH11_uc010bvg.2_Missense_Mutation_p.A578D	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	746	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						GAGAATGCAGGCCTGCTTCCC	0.587000			T	CBFB	AML								19	38					2.37509e-13	7.83535e-13	0.001523	1	0
ZP2	7783	broad.mit.edu	37	16	21215430	21215430	+	Missense_Mutation	SNP	T	A	A			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr16:21215430T>A	uc002dii.2	-	9	893	c.893A>T	c.(892-894)CAG>CTG	p.Q298L	ZP2_uc010bwn.1_Missense_Mutation_p.Q337L|ZP2_uc010bwo.2_Missense_Mutation_p.Q337L	NM_003460	NP_003451	Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 preproprotein	298	Extracellular (Potential).				binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(48;0.0573)		GTCATGCAGCTGGCTCACATC	0.428000													32	41					0	0	0.008361	0	0
FOXC2	2303	broad.mit.edu	37	16	86601010	86601010	+	Missense_Mutation	SNP	T	G	G			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr16:86601010T>G	uc002fjq.2	+	1	154	c.69T>G	c.(67-69)AAT>AAG	p.N23K		NM_005251	NP_005242	Q99958	FOXC2_HUMAN	forkhead box C2	23					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|embryonic viscerocranium morphogenesis|insulin receptor signaling pathway|lymphangiogenesis|metanephros development|negative regulation of transcription from RNA polymerase II promoter|neural crest cell fate commitment|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of cell adhesion mediated by integrin|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of vascular wound healing|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding|transcription regulatory region DNA binding				0						GCGAGCAGAATTACTACCGGG	0.701000									Late-onset_Hereditary_Lymphedema				29	42					0	0	0.006320	0	0
TSR1	55720	broad.mit.edu	37	17	2232753	2232753	+	Missense_Mutation	SNP	A	T	T			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr17:2232753A>T	uc002fuj.2	-	11	2744	c.1787T>A	c.(1786-1788)ATG>AAG	p.M596K	SNORD91B_uc002fuk.1_5'Flank	NM_018128	NP_060598	Q2NL82	TSR1_HUMAN	TSR1, 20S rRNA accumulation	596					ribosome assembly	nucleolus	protein binding			ovary(1)	1						CCTCACCACCATATTCAATAC	0.438000													22	39					0	0	0.001882	0	0
PITPNM3	83394	broad.mit.edu	37	17	6375990	6375990	+	Silent	SNP	C	T	T			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr17:6375990C>T	uc002gdd.3	-	11	1567	c.1416G>A	c.(1414-1416)CAG>CAA	p.Q472Q	PITPNM3_uc010cln.2_Silent_p.Q436Q|PITPNM3_uc010clm.2_5'UTR|PITPNM3_uc002gdc.3_Silent_p.Q63Q	NM_031220	NP_112497	Q9BZ71	PITM3_HUMAN	PITPNM family member 3 isoform 1	472	DDHD.				phosphatidylinositol metabolic process	endomembrane system|integral to membrane	calcium ion binding|lipid binding|phosphatidylinositol transporter activity|receptor tyrosine kinase binding			ovary(2)|central_nervous_system(2)	4				Colorectal(2;0.000372)|READ - Rectum adenocarcinoma(2;0.0276)|LUAD - Lung adenocarcinoma(2;0.0836)|COAD - Colon adenocarcinoma(228;0.185)		GGAGGAGGGACTGCCCATCGC	0.652000													13	11					0	0	0.001855	0	0
LOC162632	162632	broad.mit.edu	37	17	16701681	16701681	+	RNA	SNP	C	A	A			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr17:16701681C>A	uc010cpj.1	+	18		c.4212C>A			LOC162632_uc010cpk.1_RNA|LOC162632_uc010vwq.1_RNA|LOC162632_uc002gqm.2_RNA					Homo sapiens mRNA for KIAA0565 protein, partial cds.												0						CGGCTCTCTGCCAGCATCAAC	0.483000													16	106					2.94398e-08	9.42074e-08	0.007413	1	0
ST6GALNAC2	10610	broad.mit.edu	37	17	74570497	74570497	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr17:74570497C>T	uc002jsg.3	-	3	566	c.311G>A	c.(310-312)CGC>CAC	p.R104H		NM_006456	NP_006447	Q9UJ37	SIA7B_HUMAN	sialyltransferase 7B	104	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	sialyltransferase activity				0						TTGGCTCAGGCGGTCCCAGAG	0.637000													14	24					0	0	0.003163	0	0
DNAH17	8632	broad.mit.edu	37	17	76455187	76455187	+	Missense_Mutation	SNP	C	T	T	rs145638188	byFrequency	TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr17:76455187C>T	uc010dhp.1	-	6	979	c.757G>A	c.(757-759)GAG>AAG	p.E253K	DNAH17_uc002jvs.2_RNA					SubName: Full=DNAH17 variant protein; Flags: Fragment;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CAGTAGACCTCGTAGAAGCGG	0.607000													54	203					0	0	0.003610	0	0
TRMT1	55621	broad.mit.edu	37	19	13226494	13226494	+	Missense_Mutation	SNP	T	A	A			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr19:13226494T>A	uc002mwj.2	-	3	649	c.399A>T	c.(397-399)GAA>GAT	p.E133D	NACC1_uc002mwm.2_5'Flank|TRMT1_uc002mwk.2_Missense_Mutation_p.E133D|TRMT1_uc002mwl.3_Missense_Mutation_p.E133D|TRMT1_uc010xmz.1_5'UTR	NM_017722	NP_060192	Q9NXH9	TRM1_HUMAN	tRNA methyltransferase 1 isoform 1	133							RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(19;6.08e-22)	GBM - Glioblastoma multiforme(1328;0.0356)		AGGCCAGGTTTTCACTCTCTT	0.572000													92	158					0	0	0.003610	0	0
SIN3B	23309	broad.mit.edu	37	19	16964967	16964967	+	Missense_Mutation	SNP	T	C	C			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr19:16964967T>C	uc002ney.1	+	8	967	c.953T>C	c.(952-954)CTG>CCG	p.L318P	SIN3B_uc002new.2_Missense_Mutation_p.L318P|SIN3B_uc002nex.2_Missense_Mutation_p.L250P|SIN3B_uc002nez.1_Missense_Mutation_p.L318P	NM_015260	NP_056075	O75182	SIN3B_HUMAN	SIN3 homolog B, transcription regulator	318	PAH 3.|Interaction with NCOR1 (By similarity).				cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			ovary(2)	2						CGCCGGGTGCTGAAGAGCCAG	0.597000													21	31					0	0	0.003330	0	0
LSR	51599	broad.mit.edu	37	19	35757260	35757260	+	Splice_Site	SNP	A	G	G			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr19:35757260A>G	uc002nyl.2	+	6	1146	c.923_splice	c.e6-2	p.L308_splice	LSR_uc002nym.2_Splice_Site_p.L289_splice|LSR_uc002nyn.2_Splice_Site_p.V240_splice|LSR_uc002nyo.2_Splice_Site_p.L289_splice|LSR_uc010xsr.1_Splice_Site_p.M200_splice|LSR_uc002nyp.2_Splice_Site_p.L271_splice|USF2_uc010xss.1_5'Flank|USF2_uc002nyq.1_5'Flank|USF2_uc002nyr.1_5'Flank|USF2_uc002nys.1_5'Flank|USF2_uc002nyt.1_5'Flank	NM_205834	NP_991403	Q86X29	LSR_HUMAN	lipolysis stimulated lipoprotein receptor						embryo development|liver development	chylomicron|integral to membrane|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle	receptor activity				0	all_lung(56;3.91e-09)|Lung NSC(56;5.64e-09)|Esophageal squamous(110;0.162)		Epithelial(14;1.33e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.29e-18)|all cancers(14;7.11e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			GTGTCCTCACAGTGTATGCCG	0.627000													31	79					0	0	0.002445	0	0
C19orf55	148137	broad.mit.edu	37	19	36253153	36253153	+	Splice_Site	SNP	G	A	A			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr19:36253153G>A	uc002obq.1	+	5	513	c.440_splice	c.e5-1	p.A147_splice	C19orf55_uc002obp.2_Intron|C19orf55_uc002obo.1_Splice_Site_p.A147_splice	NM_001039887	NP_001034976	Q2NL68	CS055_HUMAN	hypothetical protein LOC148137											ovary(1)	1	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GGGCTTCTCAGCAGGAGCCAA	0.552000													4	17					0	0	0.000248	0	0
ZSCAN4	201516	broad.mit.edu	37	19	58187881	58187881	+	Missense_Mutation	SNP	C	G	G			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr19:58187881C>G	uc002qpu.2	+	3	1065	c.368C>G	c.(367-369)ACT>AGT	p.T123S		NM_152677	NP_689890	Q8NAM6	ZSCA4_HUMAN	zinc finger and SCAN domain containing 4	123	SCAN box.				telomere maintenance via telomere lengthening|viral reproduction	nuclear chromosome, telomeric region	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GAAGACCTGACTGATGACAGC	0.418000													23	32					0	0	0.002780	0	0
KHK	3795	broad.mit.edu	37	2	27317347	27317347	+	Missense_Mutation	SNP	T	A	A			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr2:27317347T>A	uc002ril.2	+	3	729	c.212T>A	c.(211-213)TTT>TAT	p.F71Y	KHK_uc002rim.2_Intron|KHK_uc002rin.2_Missense_Mutation_p.F72Y|KHK_uc002rio.2_Intron	NM_000221	NP_000212	P50053	KHK_HUMAN	ketohexokinase isoform a	71					fructose catabolic process	cytosol	ATP binding|ketohexokinase activity|protein binding				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCTAGCAGTTTTGTCCTGGAT	0.602000													30	72					0	0	0.002445	0	0
USP34	9736	broad.mit.edu	37	2	61450209	61450209	+	Missense_Mutation	SNP	G	C	C			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr2:61450209G>C	uc002sbe.2	-	64	7757	c.7735C>G	c.(7735-7737)CGA>GGA	p.R2579G		NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	2579					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			TCTGCAAGTCGATTATTGTAT	0.299000													7	23					0	0	0.006214	0	0
ZNF638	27332	broad.mit.edu	37	2	71576384	71576384	+	Missense_Mutation	SNP	T	G	G			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr2:71576384T>G	uc002shx.2	+	2	619	c.300T>G	c.(298-300)CAT>CAG	p.H100Q	ZNF638_uc010fec.2_Missense_Mutation_p.H206Q|ZNF638_uc010yqw.1_Intron|ZNF638_uc002shw.2_Missense_Mutation_p.H100Q|ZNF638_uc002shy.2_Missense_Mutation_p.H100Q|ZNF638_uc002shz.2_Missense_Mutation_p.H100Q|ZNF638_uc002sia.2_Missense_Mutation_p.H100Q|ZNF638_uc002sib.1_Missense_Mutation_p.H100Q	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	100					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						GGAAGCCTCATGGTAGCCGGT	0.448000													3	85					0	0	0.004672	0	0
C2orf3	6936	broad.mit.edu	37	2	75921529	75921529	+	Missense_Mutation	SNP	G	C	C			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr2:75921529G>C	uc002sno.2	-	6	988	c.858C>G	c.(856-858)CAC>CAG	p.H286Q	C2orf3_uc010ffs.2_5'UTR|C2orf3_uc002snn.2_Missense_Mutation_p.H117Q|C2orf3_uc010fft.2_5'UTR	NM_003203	NP_003194	P16383	GCF_HUMAN	hypothetical protein LOC6936	286	Potential.				negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2						GGTGTGAGCGGTGAGTTTCCT	0.289000													33	53					0	0	0.003271	0	0
C2orf55	343990	broad.mit.edu	37	2	99411105	99411105	+	Missense_Mutation	SNP	G	C	C			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr2:99411105G>C	uc002szf.1	-	10	3073	c.2779C>G	c.(2779-2781)CTG>GTG	p.L927V		NM_207362	NP_997245	Q6NV74	CB055_HUMAN	hypothetical protein LOC343990	927											0						AGCTGATGCAGTTCCTTCTCC	0.478000													47	65					0	0	0.003610	0	0
ARHGAP15	55843	broad.mit.edu	37	2	143986166	143986166	+	Missense_Mutation	SNP	T	C	C			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr2:143986166T>C	uc002tvm.3	+	5	464	c.313T>C	c.(313-315)TCC>CCC	p.S105P	ARHGAP15_uc010zbl.1_Missense_Mutation_p.S105P	NM_018460	NP_060930	Q53QZ3	RHG15_HUMAN	ARHGAP15	105	PH.				regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.151)		CTGGTCTACTTCCTGGATTGT	0.318000													18	51					0	0	0.001882	0	0
XIRP2	129446	broad.mit.edu	37	2	168103542	168103542	+	Missense_Mutation	SNP	T	A	A			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr2:168103542T>A	uc002udx.2	+	8	5658	c.5640T>A	c.(5638-5640)CAT>CAA	p.H1880Q	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.H1705Q|XIRP2_uc010fpq.2_Missense_Mutation_p.H1658Q|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1705					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AATCAAGCCATCGATGGAAAG	0.383000													15	46					0	0	0.004007	0	0
SPEG	10290	broad.mit.edu	37	2	220309733	220309733	+	Missense_Mutation	SNP	C	G	G			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr2:220309733C>G	uc010fwg.2	+	3	665	c.665C>G	c.(664-666)CCA>CGA	p.P222R	SPEG_uc002vlm.2_RNA|SPEG_uc010fwh.1_Intron|SPEG_uc002vln.1_5'UTR	NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	222					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		GGGGCCGGGCCACGGCACCTG	0.716000													7	12					0	0	0.003080	0	0
MRPL44	65080	broad.mit.edu	37	2	224824513	224824513	+	Missense_Mutation	SNP	A	G	G			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr2:224824513A>G	uc002vnr.3	+	2	511	c.442A>G	c.(442-444)ATG>GTG	p.M148V		NM_022915	NP_075066	Q9H9J2	RM44_HUMAN	mitochondrial ribosomal protein L44 precursor	148	RNase III.				RNA processing	mitochondrion|ribosome	double-stranded RNA binding|protein binding|ribonuclease III activity			central_nervous_system(1)	1		all_lung(227;0.00679)|Lung NSC(271;0.00855)|Renal(207;0.0112)|all_hematologic(139;0.189)		Epithelial(121;2.51e-10)|all cancers(144;7.89e-08)|Lung(261;0.00705)|LUSC - Lung squamous cell carcinoma(224;0.008)		GTACCCAGACATGCCCACTGA	0.428000													40	50					0	0	0.008740	0	0
SP110	3431	broad.mit.edu	37	2	231050754	231050754	+	Missense_Mutation	SNP	A	G	G			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr2:231050754A>G	uc002vqh.3	-	11	1475	c.1235T>C	c.(1234-1236)GTC>GCC	p.V412A	SP110_uc002vqg.3_Missense_Mutation_p.V412A|SP110_uc002vqi.3_Missense_Mutation_p.V412A|SP110_uc010fxk.2_Missense_Mutation_p.V410A|SP110_uc010fxj.2_Missense_Mutation_p.V55A	NM_004509	NP_004500	Q9HB58	SP110_HUMAN	SP110 nuclear body protein isoform a	412					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|signal transducer activity|zinc ion binding			ovary(2)|breast(2)	4		Renal(207;0.0112)|all_lung(227;0.0223)|Lung NSC(271;0.0983)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.169)		Epithelial(121;2.61e-12)|all cancers(144;6.39e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.0097)		TGCCTTTTGGACCCTCATCAT	0.478000													4	128					0	0	0.000602	0	0
ENTPD6	955	broad.mit.edu	37	20	25198149	25198149	+	Missense_Mutation	SNP	G	C	C			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr20:25198149G>C	uc002wuj.2	+	9	990	c.810G>C	c.(808-810)CAG>CAC	p.Q270H	ENTPD6_uc010zsy.1_Missense_Mutation_p.Q270H|ENTPD6_uc010gdj.1_Missense_Mutation_p.Q242H|ENTPD6_uc010zsz.1_Missense_Mutation_p.Q52H|ENTPD6_uc002wum.2_Missense_Mutation_p.Q253H|ENTPD6_uc010zta.1_Missense_Mutation_p.Q270H|ENTPD6_uc002wun.2_Missense_Mutation_p.Q270H|ENTPD6_uc002wuk.2_Missense_Mutation_p.Q269H|ENTPD6_uc002wul.2_Missense_Mutation_p.Q269H|ENTPD6_uc010ztb.1_Missense_Mutation_p.Q242H|ENTPD6_uc010ztc.1_Missense_Mutation_p.Q242H|ENTPD6_uc002wuo.2_Missense_Mutation_p.Q22H|ENTPD6_uc010ztd.1_Missense_Mutation_p.Q52H	NM_001247	NP_001238	O75354	ENTP6_HUMAN	ectonucleoside triphosphate diphosphohydrolase 6	270	Lumenal (Potential).					Golgi membrane|integral to membrane	nucleoside-diphosphatase activity				0						GCACCCTGCAGGCCTCCCCAC	0.537000													27	80					0	0	0.006320	0	0
ADRBK2	157	broad.mit.edu	37	22	26086189	26086189	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr22:26086189G>A	uc003abx.3	+	12	1138	c.991G>A	c.(991-993)GCA>ACA	p.A331T	ADRBK2_uc010gux.2_Missense_Mutation_p.A331T|ADRBK2_uc003abw.2_Missense_Mutation_p.A218T|ADRBK2_uc003aby.3_RNA	NM_005160	NP_005151	P35626	ARBK2_HUMAN	beta-adrenergic receptor kinase 2	331	Protein kinase.						ATP binding|beta-adrenergic receptor kinase activity|signal transducer activity			lung(3)|ovary(2)|stomach(1)|central_nervous_system(1)	7					Adenosine triphosphate(DB00171)	ACATGGACACGCAAGAATATC	0.413000													7	28					0	0	0.003080	0	0
GOLGA4	2803	broad.mit.edu	37	3	37365472	37365472	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr3:37365472G>A	uc003cgv.2	+	14	2399	c.2095G>A	c.(2095-2097)GCC>ACC	p.A699T	GOLGA4_uc010hgr.1_Missense_Mutation_p.A260T|GOLGA4_uc003cgw.2_Missense_Mutation_p.A721T|GOLGA4_uc010hgs.2_Intron|GOLGA4_uc003cgx.2_Missense_Mutation_p.A580T	NM_002078	NP_002069	Q13439	GOGA4_HUMAN	golgi autoantigen, golgin subfamily a, 4	699	Potential.|Glu-rich.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4						AGTATTAAAAGCCCGTCACAA	0.358000													26	7					0	0	0.003954	0	0
ACY1	95	broad.mit.edu	37	3	52023049	52023049	+	Silent	SNP	G	C	C			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr3:52023049G>C	uc003dcp.2	+	15	1246	c.1185G>C	c.(1183-1185)CTG>CTC	p.L395L	ACY1_uc011bea.1_Silent_p.L485L|ACY1_uc003dcq.2_Silent_p.L395L	NM_000666	NP_000657	Q03154	ACY1_HUMAN	aminoacylase 1	395					cellular amino acid metabolic process|proteolysis	cytosol	aminoacylase activity|metal ion binding|metallopeptidase activity			breast(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	L-Aspartic Acid(DB00128)	CACGCCTGCTGCCTGCCCTTG	0.607000													82	23					0	0	0.003610	0	0
PBRM1	55193	broad.mit.edu	37	3	52651555	52651555	+	Splice_Site	SNP	C	T	T			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr3:52651555C>T	uc003des.2	-	14	1554	c.1542_splice	c.e14-1	p.S514_splice	PBRM1_uc003dex.2_Splice_Site|PBRM1_uc003deq.2_Splice_Site_p.S514_splice|PBRM1_uc003der.2_Splice_Site_p.S482_splice|PBRM1_uc003det.2_Splice_Site_p.S529_splice|PBRM1_uc003deu.2_Splice_Site_p.S529_splice|PBRM1_uc003dev.2_Splice_Site|PBRM1_uc003dew.2_Splice_Site_p.S514_splice|PBRM1_uc010hmk.1_Splice_Site_p.S514_splice|PBRM1_uc003dey.2_Splice_Site_p.S514_splice|PBRM1_uc003dez.1_Splice_Site_p.S514_splice|PBRM1_uc003dfb.1_Splice_Site_p.S427_splice|PBRM1_uc003dfc.2_5'Flank	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4						chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		GTTCTTTTTACTGTTGAGGGG	0.348000			Mis|N|F|S|D|O		clear cell renal carcinoma|breast								21	10					0	0	0.001882	0	0
KIAA2018	205717	broad.mit.edu	37	3	113377559	113377559	+	Silent	SNP	T	C	C			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr3:113377559T>C	uc003eam.2	-	7	3381	c.2970A>G	c.(2968-2970)TCA>TCG	p.S990S	KIAA2018_uc003eal.2_Silent_p.S934S	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	990					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						GCATTGTATCTGATGAATCTT	0.393000													86	28					0	0	0.003610	0	0
CD86	942	broad.mit.edu	37	3	121822644	121822644	+	Missense_Mutation	SNP	C	G	G			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr3:121822644C>G	uc003eet.2	+	3	466	c.350C>G	c.(349-351)CCC>CGC	p.P117R	CD86_uc011bjo.1_Missense_Mutation_p.P35R|CD86_uc011bjp.1_Intron|CD86_uc003eeu.2_Missense_Mutation_p.P111R	NM_175862	NP_787058	P42081	CD86_HUMAN	CD86 antigen isoform 1	117	Ig-like V-type.|Extracellular (Potential).				interspecies interaction between organisms|positive regulation of cell proliferation|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of lymphotoxin A biosynthetic process|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation		coreceptor activity|protein binding			pancreas(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.156)	Abatacept(DB01281)	CACAAAAAGCCCACAGGAATG	0.453000													54	10					0	0	0.003610	0	0
MUC4	4585	broad.mit.edu	37	3	195505772	195505772	+	Missense_Mutation	SNP	C	G	G			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr3:195505772C>G	uc011bto.1	-	3	12755	c.12295G>C	c.(12295-12297)GTC>CTC	p.V4099L	MUC4_uc003fva.2_5'Flank|MUC4_uc003fvb.2_5'Flank|MUC4_uc003fvc.2_5'Flank|MUC4_uc003fvd.2_5'Flank|MUC4_uc003fve.2_5'Flank|MUC4_uc010hzr.2_5'Flank|MUC4_uc011btf.1_Intron|MUC4_uc011btg.1_Intron|MUC4_uc011bth.1_Intron|MUC4_uc011bti.1_Intron|MUC4_uc011btj.1_Intron|MUC4_uc011btk.1_Intron|MUC4_uc011btl.1_Intron|MUC4_uc011btm.1_Intron|MUC4_uc011btn.1_Intron|MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	984	Ser-rich.				cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		AGGCTGGTGACAGGAAGAGGG	0.582000													2	7					0	0	0.004672	0	0
SMAD1	4086	broad.mit.edu	37	4	146475084	146475084	+	Missense_Mutation	SNP	T	G	G			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr4:146475084T>G	uc003ikc.2	+	6	1562	c.1146T>G	c.(1144-1146)ATT>ATG	p.I382M	SMAD1_uc003ikd.2_Missense_Mutation_p.I382M|SMAD1_uc010iov.2_Missense_Mutation_p.I382M|SMAD1_uc011cic.1_Missense_Mutation_p.I343M	NM_005900	NP_005891	Q15797	SMAD1_HUMAN	Sma- and Mad-related protein 1	382	MH2.				BMP signaling pathway|embryonic pattern specification|primary miRNA processing|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway	cytosol|integral to membrane|nuclear inner membrane	co-SMAD binding|I-SMAD binding|identical protein binding|protein kinase binding|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity			ovary(1)	1	all_hematologic(180;0.151)					GTCTGAAAATTTTTAACAACC	0.398000													30	54					0	0	0.001786	0	0
IRF2	3660	broad.mit.edu	37	4	185339324	185339324	+	Missense_Mutation	SNP	G	C	C			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr4:185339324G>C	uc003iwf.3	-	5	608	c.408C>G	c.(406-408)ATC>ATG	p.I136M		NM_002199	NP_002190	P14316	IRF2_HUMAN	interferon regulatory factor 2	136					blood coagulation|cell proliferation|interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	focal adhesion|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		all_lung(41;7.86e-14)|Lung NSC(41;1.87e-13)|Colorectal(36;0.00146)|Hepatocellular(41;0.00826)|Renal(120;0.00992)|Prostate(90;0.0115)|all_neural(102;0.0573)|all_hematologic(60;0.0592)		all cancers(43;3.94e-27)|Epithelial(43;5.3e-24)|OV - Ovarian serous cystadenocarcinoma(60;1.06e-10)|Colorectal(24;7.98e-07)|STAD - Stomach adenocarcinoma(60;3.95e-05)|GBM - Glioblastoma multiforme(59;8.3e-05)|COAD - Colon adenocarcinoma(29;0.000106)|BRCA - Breast invasive adenocarcinoma(30;0.000311)|LUSC - Lung squamous cell carcinoma(40;0.0128)|READ - Rectum adenocarcinoma(43;0.0419)		AGATTACCTTGATGTGCTTAA	0.398000													53	97					0	0	0.003610	0	0
FAT1	2195	broad.mit.edu	37	4	187525694	187525694	+	Missense_Mutation	SNP	A	G	G			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr4:187525694A>G	uc003izf.2	-	18	10573	c.10385T>C	c.(10384-10386)CTG>CCG	p.L3462P		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3462	Extracellular (Potential).|Cadherin 32.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TGTTACTACCAGCTGCAGCAC	0.418000										HNSCC(5;0.00058)			12	20					0	0	0.000978	0	0
ADCY2	108	broad.mit.edu	37	5	7766912	7766912	+	Missense_Mutation	SNP	T	G	G			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr5:7766912T>G	uc003jdz.1	+	17	2274	c.2207T>G	c.(2206-2208)TTC>TGC	p.F736C	ADCY2_uc011cmo.1_Missense_Mutation_p.F556C	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	736	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						AATTTATTTTTCCTCCCGGTA	0.428000													74	135					0	0	0.003610	0	0
UGT3A2	167127	broad.mit.edu	37	5	36039694	36039694	+	Missense_Mutation	SNP	A	C	C			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr5:36039694A>C	uc003jjz.1	-	5	1053	c.960T>G	c.(958-960)TTT>TTG	p.F320L	UGT3A2_uc011cos.1_Missense_Mutation_p.F286L|UGT3A2_uc011cot.1_Missense_Mutation_p.F18L	NM_174914	NP_777574	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	320	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GTAGGTGAGCAAAGGCATTGT	0.493000													39	65					0	0	0.006230	0	0
SNRPC	6631	broad.mit.edu	37	6	34730469	34730469	+	Missense_Mutation	SNP	T	C	C			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr6:34730469T>C	uc003ojt.1	+	3	164	c.149T>C	c.(148-150)ATT>ACT	p.I50T		NM_003093	NP_003084	P09234	RU1C_HUMAN	small nuclear ribonucleoprotein polypeptide C	50					spliceosomal snRNP assembly	Cajal body|U1 snRNP	protein homodimerization activity|single-stranded RNA binding|zinc ion binding			pancreas(1)	1						CAGAGCCTGATTGACAAAACA	0.413000													5	15					0	0	0.000602	0	0
PPARD	5467	broad.mit.edu	37	6	35392132	35392132	+	Silent	SNP	A	C	C			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr6:35392132A>C	uc003okm.2	+	7	963	c.654A>C	c.(652-654)ACA>ACC	p.T218T	PPARD_uc003okl.2_Silent_p.T218T|PPARD_uc003okn.2_Silent_p.T218T|PPARD_uc011dtb.1_Silent_p.T179T|PPARD_uc011dtc.1_Silent_p.T120T	NM_006238	NP_006229	Q03181	PPARD_HUMAN	peroxisome proliferative activated receptor,	218					apoptosis|axon ensheathment|cholesterol metabolic process|decidualization|embryo implantation|fatty acid beta-oxidation|fatty acid transport|generation of precursor metabolites and energy|glucose metabolic process|glucose transport|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fat cell differentiation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|linoleic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1					Icosapent(DB00159)|Sulindac(DB00605)|Treprostinil(DB00374)	ACATCGAGACATTGTGGCAGG	0.597000													17	28					0	0	0.008871	0	0
TCTE1	202500	broad.mit.edu	37	6	44254102	44254102	+	Missense_Mutation	SNP	C	T	T	rs149566851		TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr6:44254102C>T	uc003oxi.2	-	3	601	c.445G>A	c.(445-447)GGC>AGC	p.G149S	SPATS1_uc003oxg.2_Intron|TMEM151B_uc003oxf.2_Intron	NM_182539	NP_872345	Q5JU00	TCTE1_HUMAN	t-complex-associated testis expressed 1	149										ovary(2)|skin(2)	4	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TTCCAGCTGCCGCCATGGTGG	0.612000													20	65					0	0	0.008871	0	0
TDRD6	221400	broad.mit.edu	37	6	46660547	46660547	+	Missense_Mutation	SNP	G	C	C			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr6:46660547G>C	uc003oyj.2	+	1	4682	c.4682G>C	c.(4681-4683)AGG>ACG	p.R1561T	TDRD6_uc010jze.2_Missense_Mutation_p.R1555T	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1561					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			GTAGCAGACAGGAGAAATTGT	0.383000													25	34					0	0	0.003330	0	0
FAM46A	55603	broad.mit.edu	37	6	82461531	82461531	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr6:82461531C>T	uc003pjg.2	-	2	646	c.328G>A	c.(328-330)GAG>AAG	p.E110K	FAM46A_uc003pjf.2_Missense_Mutation_p.E129K|FAM46A_uc003pjh.1_Missense_Mutation_p.E110K	NM_017633	NP_060103	Q96IP4	FA46A_HUMAN	hypothetical protein LOC55603	110											0		all_cancers(76;6.74e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000282)|all_epithelial(107;0.0104)		BRCA - Breast invasive adenocarcinoma(397;0.0428)		ATGCGCTTCTCGGCCAGGCGC	0.672000													24	27					0	0	0.006320	0	0
ROS1	6098	broad.mit.edu	37	6	117706858	117706858	+	Silent	SNP	T	A	A			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr6:117706858T>A	uc003pxp.1	-	15	2491	c.2292A>T	c.(2290-2292)GGA>GGT	p.G764G	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	764	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		CATATGTCTTTCCAGCCCAGT	0.368000			T	GOPC|ROS1	glioblastoma|NSCLC								45	56					0	0	0.003610	0	0
RAET1G	353091	broad.mit.edu	37	6	150240371	150240371	+	Missense_Mutation	SNP	T	C	C			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr6:150240371T>C	uc010kii.1	-	3	507	c.439A>G	c.(439-441)ATC>GTC	p.I147V	uc003qni.1_RNA|RAET1G_uc003qnm.2_RNA	NM_001001788	NP_001001788	Q6H3X3	RET1G_HUMAN	retinoic acid early transcript 1G precursor	147	Extracellular (Potential).|MHC class I alpha-2 like.				antigen processing and presentation|immune response	integral to membrane|MHC class I protein complex	protein binding				0		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.73e-12)		AGGAGGAAGATCTGTCCATCG	0.507000													46	61					0	0	0.003610	0	0
PSMB1	5689	broad.mit.edu	37	6	170844433	170844433	+	Missense_Mutation	SNP	G	A	A			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr6:170844433G>A	uc011ehe.1	-	6	688	c.601C>T	c.(601-603)CGG>TGG	p.R201W	PSMB1_uc003qxq.2_Intron|PSMB1_uc003qxr.2_Missense_Mutation_p.R100W	NM_002793	NP_002784	P20618	PSB1_HUMAN	proteasome beta 1 subunit precursor	201					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cell junction|cytoplasm|nucleus|proteasome core complex	protein binding|threonine-type endopeptidase activity			ovary(1)	1		Breast(66;5.08e-05)|Ovarian(120;0.0563)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;7.5e-23)|BRCA - Breast invasive adenocarcinoma(81;4.88e-06)|GBM - Glioblastoma multiforme(31;0.00643)	Bortezomib(DB00188)	TTCACCAGCCGCATGGCTCTG	0.517000													6	77					0	0	0.001168	0	0
HEATR2	54919	broad.mit.edu	37	7	813765	813765	+	Missense_Mutation	SNP	C	T	T			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr7:813765C>T	uc010krz.1	+	10	2032	c.2012C>T	c.(2011-2013)GCG>GTG	p.A671V	HEATR2_uc003siz.2_Missense_Mutation_p.A539V|HEATR2_uc003sjb.2_Missense_Mutation_p.A51V|HEATR2_uc003sjc.2_Missense_Mutation_p.A96V	NM_017802	NP_060272	Q86Y56	HEAT2_HUMAN	HEAT repeat containing 2	671							protein binding			skin(1)	1		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0182)|Epithelial(4;5.48e-17)|OV - Ovarian serous cystadenocarcinoma(56;1.95e-16)|all cancers(6;2.98e-14)		AGGACAGCCGCGGCCATCCGC	0.672000													5	118					0	0	0.000602	0	0
HECW1	23072	broad.mit.edu	37	7	43581576	43581576	+	Silent	SNP	T	A	A			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr7:43581576T>A	uc003tid.1	+	26	4832	c.4227T>A	c.(4225-4227)GTT>GTA	p.V1409V	HECW1_uc011kbi.1_Silent_p.V1375V	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	1409	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						CTTTCACTGTTAATGAAGAGG	0.323000													6	128					0	0	0.001984	0	0
GNAI1	2770	broad.mit.edu	37	7	79842142	79842142	+	Silent	SNP	A	G	G			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr7:79842142A>G	uc003uhb.1	+	7	1168	c.831A>G	c.(829-831)AAA>AAG	p.K277K	GNAI1_uc011kgt.1_Silent_p.K225K	NM_002069	NP_002060	P63096	GNAI1_HUMAN	guanine nucleotide binding protein (G protein),	277					cell cycle|cell division|inhibition of adenylate cyclase activity by G-protein signaling pathway|platelet activation|synaptic transmission	centrosome|heterotrimeric G-protein complex|midbody|nucleus	G-protein beta/gamma-subunit complex binding|GTP binding|metabotropic serotonin receptor binding|signal transducer activity			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						TTGAAGAAAAAATCAAAAAGA	0.323000													65	154					0	0	0.003610	0	0
SAMD9	54809	broad.mit.edu	37	7	92734539	92734539	+	Missense_Mutation	SNP	T	G	G			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr7:92734539T>G	uc003umf.2	-	3	1128	c.872A>C	c.(871-873)GAA>GCA	p.E291A	SAMD9_uc003umg.2_Missense_Mutation_p.E291A	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	291						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			CAGTAAAACTTCCACAAATCT	0.353000													43	40					0	0	0.002852	0	0
EPHB4	2050	broad.mit.edu	37	7	100417814	100417814	+	Missense_Mutation	SNP	G	T	T			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr7:100417814G>T	uc003uwn.1	-	5	1404	c.913C>A	c.(913-915)CGC>AGC	p.R305S	EPHB4_uc003uwm.1_Missense_Mutation_p.R212S|EPHB4_uc010lhj.1_Missense_Mutation_p.R305S|EPHB4_uc011kkf.1_Missense_Mutation_p.R305S|EPHB4_uc011kkg.1_Intron|EPHB4_uc011kkh.1_Missense_Mutation_p.R305S	NM_004444	NP_004435	P54760	EPHB4_HUMAN	EPH receptor B4 precursor	305	Extracellular (Potential).|Cys-rich.				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(4)|stomach(3)|skin(3)|central_nervous_system(2)|ovary(2)|breast(1)	15	Lung NSC(181;0.041)|all_lung(186;0.0581)					TACCCGACGCGGCACTGGCAG	0.642000													6	245					0.00307968	0.00956793	0.003080	1	0
SLC26A5	375611	broad.mit.edu	37	7	103029511	103029511	+	Silent	SNP	A	G	G			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr7:103029511A>G	uc003vbz.2	-	14	1694	c.1458T>C	c.(1456-1458)TAT>TAC	p.Y486Y	SLC26A5_uc003vbt.1_Silent_p.Y486Y|SLC26A5_uc003vbu.1_Silent_p.Y486Y|SLC26A5_uc003vbv.1_Intron|SLC26A5_uc003vbw.2_RNA|SLC26A5_uc003vbx.2_Silent_p.Y454Y|SLC26A5_uc003vby.2_RNA|SLC26A5_uc010liy.2_RNA	NM_198999	NP_945350	P58743	S26A5_HUMAN	prestin isoform a	486	Helical; Name=12; (Potential).				regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			ovary(1)	1						TGATCAAACCATAGTCCAATC	0.458000													14	50					0	0	0.003163	0	0
KIAA1549	57670	broad.mit.edu	37	7	138602963	138602963	+	Missense_Mutation	SNP	T	C	C			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr7:138602963T>C	uc011kql.1	-	2	1458	c.1409A>G	c.(1408-1410)GAC>GGC	p.D470G	KIAA1549_uc003vuk.3_Missense_Mutation_p.D420G|KIAA1549_uc011kqj.1_Missense_Mutation_p.D470G	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	470						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						TTCAGAGAAGTCTGCTACGAC	0.483000			O	BRAF	pilocytic astrocytoma								20	46					0	0	0.001882	0	0
TMEM176B	28959	broad.mit.edu	37	7	150493608	150493608	+	Missense_Mutation	SNP	G	C	C			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr7:150493608G>C	uc003wht.3	-	2	216	c.50C>G	c.(49-51)CCA>CGA	p.P17R	TMEM176B_uc003whu.3_Missense_Mutation_p.P17R|TMEM176B_uc003whv.3_Missense_Mutation_p.P17R|TMEM176B_uc003whw.3_Missense_Mutation_p.P17R	NM_001101313	NP_001094783	Q3YBM2	T176B_HUMAN	transmembrane protein 176B isoform a	17				PS -> HA (in Ref. 1; AAD23440).	cell differentiation|organ morphogenesis	integral to membrane|nuclear membrane				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGGCTGGGATGGCCTAGAGGC	0.522000													5	95					0	0	0.001168	0	0
ZFHX4	79776	broad.mit.edu	37	8	77617295	77617296	+	Missense_Mutation	DNP	GA	TT	TT			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr8:77617295_77617296GA>TT	uc003yav.2	+	2	1359_1360	c.972_973GA>TT	c.(970-975)GGGATT>GGTTTT	p.I325F	ZFHX4_uc003yat.1_Missense_Mutation_p.I325F|ZFHX4_uc003yau.1_Missense_Mutation_p.I325F|ZFHX4_uc003yaw.1_Missense_Mutation_p.I325F	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	325						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TAATACAGGGGATTGGCAAAGA	0.441000										HNSCC(33;0.089)			51	78					0	0	0.004672	0	0
GSPT2	23708	broad.mit.edu	37	X	51486959	51486960	+	Missense_Mutation	DNP	GC	TT	TT			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chrX:51486959_51486960GC>TT	uc004dpl.2	+	1	463_464	c.237_238GC>TT	c.(235-240)CCGCCC>CCTTCC	p.P80S		NM_018094	NP_060564	Q8IYD1	ERF3B_HUMAN	peptide chain release factor 3	80					cell cycle|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|translational termination	cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)	1	Ovarian(276;0.236)					CGACTCAGCCGCCCACCCTCCC	0.658000													7	15					0	0	0.004672	0	0
LAS1L	81887	broad.mit.edu	37	X	64749564	64749564	+	Nonsense_Mutation	SNP	C	A	A			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chrX:64749564C>A	uc004dwa.1	-	5	781	c.709G>T	c.(709-711)GAG>TAG	p.E237*	LAS1L_uc004dwc.1_Nonsense_Mutation_p.E237*|LAS1L_uc004dwd.1_Nonsense_Mutation_p.E195*	NM_031206	NP_112483	Q9Y4W2	LAS1L_HUMAN	LAS1-like	237						MLL1 complex|nucleolus	protein binding			ovary(3)|large_intestine(1)	4						ACATCTGACTCCGTACTTTTC	0.453000													57	117					1.53716e-24	5.17779e-24	0.003610	1	0
KIF4A	24137	broad.mit.edu	37	X	69637856	69637856	+	Splice_Site	SNP	T	C	C			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chrX:69637856T>C	uc004dyg.2	+	29	3499	c.3372_splice	c.e29+2	p.K1124_splice	KIF4A_uc010nkw.2_Splice_Site_p.K1124_splice	NM_012310	NP_036442	O95239	KIF4A_HUMAN	kinesin family member 4						anterograde axon cargo transport|axon guidance|blood coagulation|organelle organization	chromosome|cytosol|midbody|nuclear matrix|spindle microtubule	ATP binding|DNA binding|microtubule motor activity|protein binding			ovary(4)	4						CAAGGCAAGGTAGGATCAGGG	0.537000													33	61					0	0	0.004289	0	0
SLITRK2	84631	broad.mit.edu	37	X	144904633	144904635	+	Nonsense_Mutation	TNP	GCT	CTA	CTA			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chrX:144904633_144904635GCT>CTA	uc004fcd.2	+	5	1680_1682	c.690_692GCT>CTA	c.(688-693)TGGCTA>TGCTAA	p.230_231WL>C*	SLITRK2_uc010nsp.2_Nonsense_Mutation_p.230_231WL>C*|SLITRK2_uc010nso.2_Nonsense_Mutation_p.230_231WL>C*|SLITRK2_uc011mwq.1_Nonsense_Mutation_p.230_231WL>C*|SLITRK2_uc011mwr.1_Nonsense_Mutation_p.230_231WL>C*|SLITRK2_uc011mws.1_Nonsense_Mutation_p.230_231WL>C*|SLITRK2_uc004fcg.2_Nonsense_Mutation_p.230_231WL>C*|SLITRK2_uc011mwt.1_Nonsense_Mutation_p.230_231WL>C*	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	230_231	Extracellular (Potential).|LRRCT 1.					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					TCAAGGCCTGGCTAGACACCATA	0.493000													26	112					0	0	0.004672	0	0
OPN1MW	2652	broad.mit.edu	37	X	153496172	153496172	+	Missense_Mutation	SNP	C	A	A			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chrX:153496172C>A	uc004fkd.2	+	5	982	c.900C>A	c.(898-900)CAC>CAA	p.H300Q		NM_000513	NP_000504	P04001	OPSG_HUMAN	opsin 1 (cone pigments), medium-wave-sensitive	300	Extracellular.				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity				0	all_cancers(53;1.83e-16)|all_epithelial(53;2.73e-10)|all_lung(58;6.39e-07)|Lung NSC(58;8.37e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ACCCCTTCCACCCTTTGATGG	0.557000													84	25					1.24258e-46	4.27555e-46	0.003610	1	0
ASPM	259266	broad.mit.edu	37	1	197073973	197073974	+	Frame_Shift_Ins	INS	-	A	A			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr1:197073973_197073974insA	uc001gtu.2	-	18	4664_4665	c.4407_4408insT	c.(4405-4410)ATTATCfs	p.I1469fs	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	1469_1470					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						GATTGTATGATAATAGCAGAAT	0.292													45	14	---	---	---	---					
ANKRD26	22852	broad.mit.edu	37	10	27349330	27349331	+	In_Frame_Ins	INS	-	TCA	TCA			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr10:27349330_27349331insTCA	uc001ith.2	-	15	1679_1680	c.1507_1508insTGA	c.(1507-1509)AAA>ATGAAA	p.502_503insM	ANKRD26_uc001itg.2_In_Frame_Ins_p.188_189insM|ANKRD26_uc009xku.1_In_Frame_Ins_p.502_503insM	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	502_503						centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4						AACAGAATCTTTCATTTCAATG	0.277													44	99	---	---	---	---					
NCAPD3	23310	broad.mit.edu	37	11	134038822	134038822	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr11:134038822delG	uc001qhd.1	-	25	3835	c.3229delC	c.(3229-3231)CAGfs	p.Q1077fs	NCAPD3_uc010scm.1_RNA|NCAPD3_uc009zda.1_RNA|NCAPD3_uc001qhc.1_Frame_Shift_Del_p.Q27fs	NM_015261	NP_056076	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3	1077					cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	5	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		CTCTCTGACTGGGGGAACTTG	0.443													35	57	---	---	---	---					
MGA	23269	broad.mit.edu	37	15	42041819	42041837	+	Frame_Shift_Del	DEL	CTAATGTAATAAAACAAAA	-	-			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr15:42041819_42041837delCTAATGTAATAAAACAAAA	uc010ucy.1	+	17	6195_6213	c.6014_6032delCTAATGTAATAAAACAAAA	c.(6013-6033)GCTAATGTAATAAAACAAAACfs	p.A2005fs	MGA_uc010ucz.1_Frame_Shift_Del_p.A1796fs|MGA_uc010uda.1_Frame_Shift_Del_p.A621fs|MGA_uc001zoi.2_Frame_Shift_Del_p.A219fs	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	1966_1972	Basic motif.					MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		GACCCTGAGGCTAATGTAATAAAACAAAACTCAGGAGCT	0.416													24	87	---	---	---	---					
C16orf62	57020	broad.mit.edu	37	16	19711796	19711797	+	Frame_Shift_Ins	INS	-	G	G			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr16:19711796_19711797insG	uc002dgn.1	+	31	2902_2903	c.2890_2891insG	c.(2890-2892)TGAfs	p.*964fs	C16orf62_uc002dgo.1_Frame_Shift_Ins_p.*871fs|C16orf62_uc002dgp.1_Frame_Shift_Ins_p.*713fs	NM_020314	NP_064710	Q7Z3J2	CP062_HUMAN	hypothetical protein LOC57020	964						integral to membrane				ovary(1)	1						AACAAGGACCTGACCCCCGGGC	0.510													28	53	---	---	---	---					
ZNF564	163050	broad.mit.edu	37	19	12639496	12639497	+	Frame_Shift_Del	DEL	AG	-	-			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr19:12639496_12639497delAG	uc002mty.2	-	2	227_228	c.17_18delCT	c.(16-18)TCTfs	p.S6fs	ZNF709_uc002mtx.3_Intron	NM_144976	NP_659413	Q8TBZ8	ZN564_HUMAN	zinc finger protein 564	6	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CCACATCCTCAGAGGCCACTGA	0.441													54	92	---	---	---	---					
SETD2	29072	broad.mit.edu	37	3	47164114	47164114	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr3:47164114delA	uc003cqs.2	-	3	2065	c.2012delT	c.(2011-2013)TTAfs	p.L671fs	SETD2_uc003cqv.2_Frame_Shift_Del_p.L660fs	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	671					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		ATTTATATTTAATTCTATGGG	0.328			N|F|S|Mis		clear cell renal carcinoma								70	15	---	---	---	---					
PDE7B	27115	broad.mit.edu	37	6	136512787	136512788	+	Frame_Shift_Ins	INS	-	A	A			TCGA-BQ-7061-01A-11D-1961-08	TCGA-BQ-7061-11A-01D-1961-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae48a526-0daa-42b6-b98e-1453e9dc631a	4968c132-2d26-4a31-ab07-6d7c154551de	g.chr6:136512787_136512788insA	uc003qgp.2	+	13	1465_1466	c.1162_1163insA	c.(1162-1164)GAAfs	p.E388fs	uc003qgq.1_Intron|PDE7B_uc003qgr.2_Frame_Shift_Ins_p.E440fs	NM_018945	NP_061818	Q9NP56	PDE7B_HUMAN	phosphodiesterase 7B	388	Catalytic (By similarity).				signal transduction|synaptic transmission	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(1)	1	Colorectal(23;0.24)			OV - Ovarian serous cystadenocarcinoma(155;0.0136)|GBM - Glioblastoma multiforme(68;0.0147)	Dyphylline(DB00651)|Ketotifen(DB00920)	GCTCTTCCGGGAATGGGCCCAT	0.589													12	23	---	---	---	---					
