Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_status	validation_method	validation_tumor_sample	validation_alt_allele
KPNA6	23633	broad.mit.edu	37	1	32631598	32631599	+	Intron	INS	-	A	A	rs77903899		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:32631598_32631599insA	uc001bug.2	+						KPNA6_uc001buh.2_Intron|KPNA6_uc010ogx.1_Intron|KPNA6_uc010ogy.1_Intron|KPNA6_uc009vtz.2_Intron	NM_012316	NP_036448			karyopherin alpha 6						NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)																---	---	---	---
CGN	57530	broad.mit.edu	37	1	151506277	151506277	+	Intron	DEL	A	-	-			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:151506277delA	uc009wmw.2	+						CGN_uc010pde.1_5'Flank	NM_020770	NP_065821			cingulin							myosin complex|tight junction	actin binding|motor activity			ovary(2)|pancreas(1)	3	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)															---	---	---	---
Unknown	0	broad.mit.edu	37	2	64602785	64602786	+	IGR	INS	-	CAC	CAC	rs74709929		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:64602785_64602786insCAC								PELI1 (231180 upstream) : HSPC159 (78541 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	2	114424982	114424985	+	IGR	DEL	TTTA	-	-			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:114424982_114424985delTTTA								RABL2A (24008 upstream) : SLC35F5 (46946 downstream)																																			---	---	---	---
MOGAT1	116255	broad.mit.edu	37	2	223562830	223562831	+	Intron	INS	-	T	T	rs148576038	by1000genomes	TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:223562830_223562831insT	uc010fws.1	+						MOGAT1_uc010fwt.1_Intron	NM_058165	NP_477513			monoacylglycerol O-acyltransferase 1						glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			breast(1)	1		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;2.06e-07)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0105)														---	---	---	---
ARHGEF3	50650	broad.mit.edu	37	3	56771523	56771524	+	Intron	INS	-	A	A	rs11443478		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:56771523_56771524insA	uc003dig.2	-						ARHGEF3_uc011bew.1_Intron|ARHGEF3_uc003dih.2_Intron|ARHGEF3_uc011bev.1_Intron|ARHGEF3_uc003dif.2_Intron|ARHGEF3_uc010hmy.1_Intron|ARHGEF3_uc003dii.2_Intron	NM_019555	NP_062455			Rho guanine nucleotide exchange factor 3 isoform						apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0161)|Kidney(284;0.019)|OV - Ovarian serous cystadenocarcinoma(275;0.193)														---	---	---	---
FRYL	285527	broad.mit.edu	37	4	48625213	48625213	+	Intron	DEL	C	-	-	rs776579	by1000genomes	TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:48625213delC	uc003gyh.1	-						FRYL_uc003gyk.2_Intron|FRYL_uc003gyl.1_Intron|FRYL_uc003gym.1_Intron	NM_015030	NP_055845			furry-like						regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1																		---	---	---	---
DDX46	9879	broad.mit.edu	37	5	134140863	134140864	+	Intron	INS	-	T	T	rs113554220		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:134140863_134140864insT	uc003kzw.2	+						DDX46_uc003kzv.1_Intron	NM_014829	NP_055644			DEAD (Asp-Glu-Ala-Asp) box polypeptide 46						mRNA processing|RNA splicing	Cajal body|nuclear speck	ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)															---	---	---	---
PCDHGA11	56105	broad.mit.edu	37	5	140803317	140803318	+	Intron	INS	-	G	G	rs144521096	by1000genomes	TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140803317_140803318insG	uc003lkq.1	+						PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lko.1_3'UTR|PCDHGA11_uc003lkp.1_Intron|PCDHGB8P_uc011daz.1_5'Flank	NM_018914	NP_061737			protocadherin gamma subfamily A, 11 isoform 1						homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
CLINT1	9685	broad.mit.edu	37	5	157241368	157241368	+	Intron	DEL	A	-	-	rs140043015		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:157241368delA	uc003lxj.1	-						CLINT1_uc003lxi.1_Intron|CLINT1_uc011ddv.1_Intron	NM_014666	NP_055481			epsin 4						endocytosis|post-Golgi vesicle-mediated transport	clathrin-coated vesicle|cytosol|Golgi apparatus|membrane|perinuclear region of cytoplasm	clathrin binding|lipid binding			ovary(2)|pancreas(1)	3	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)															---	---	---	---
MDN1	23195	broad.mit.edu	37	6	90409616	90409616	+	Intron	DEL	A	-	-			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:90409616delA	uc003pnn.1	-							NM_014611	NP_055426			MDN1, midasin homolog						protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)														---	---	---	---
INTS1	26173	broad.mit.edu	37	7	1514107	1514108	+	Intron	INS	-	AC	AC	rs143283428	by1000genomes	TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:1514107_1514108insAC	uc003skn.2	-						INTS1_uc003skm.1_Intron	NM_001080453	NP_001073922			integrator complex subunit 1						snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)														---	---	---	---
NOS3	4846	broad.mit.edu	37	7	150706436	150706437	+	Intron	INS	-	C	C	rs142498418	by1000genomes	TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:150706436_150706437insC	uc003wif.2	+						NOS3_uc011kuy.1_Intron	NM_000603	NP_000594			nitric oxide synthase 3 isoform 1						anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			central_nervous_system(5)|large_intestine(2)|skin(1)	8	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)													---	---	---	---
Unknown	0	broad.mit.edu	37	8	70856284	70856284	+	IGR	DEL	A	-	-			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:70856284delA								SLCO5A1 (108985 upstream) : PRDM14 (107741 downstream)																																			---	---	---	---
C9orf5	23731	broad.mit.edu	37	9	111870700	111870701	+	Intron	INS	-	A	A	rs35388228		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:111870700_111870701insA	uc004bdt.3	-						C9orf5_uc004bds.3_Intron|C9orf5_uc004bdr.3_Intron	NM_032012	NP_114401			hypothetical protein LOC23731							integral to membrane				central_nervous_system(1)	1		Myeloproliferative disorder(63;0.204)		OV - Ovarian serous cystadenocarcinoma(323;3.08e-05)|STAD - Stomach adenocarcinoma(157;0.0823)														---	---	---	---
PPP2R4	5524	broad.mit.edu	37	9	131882706	131882706	+	Intron	DEL	G	-	-	rs3124504		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131882706delG	uc004bxm.1	+						PPP2R4_uc004bxl.1_Intron|PPP2R4_uc011mbo.1_Intron|PPP2R4_uc010myr.1_Intron|PPP2R4_uc004bxn.1_Intron|PPP2R4_uc004bxo.1_Intron|PPP2R4_uc011mbp.1_Intron|PPP2R4_uc011mbq.1_Intron|PPP2R4_uc010mys.1_Intron	NM_178001	NP_821068			protein phosphatase 2A, regulatory subunit B'						ATP catabolic process|negative regulation of phosphoprotein phosphatase activity|negative regulation of protein dephosphorylation|positive regulation of apoptosis|positive regulation of phosphoprotein phosphatase activity|positive regulation of protein dephosphorylation	calcium channel complex|cytoplasm|nucleus|protein phosphatase type 2A complex|soluble fraction	ATP binding|peptidyl-prolyl cis-trans isomerase activity|protein heterodimerization activity|protein homodimerization activity|protein phosphatase 2A binding|protein phosphatase type 2A regulator activity|protein tyrosine phosphatase activator activity|receptor binding			ovary(1)|lung(1)|pancreas(1)	3		Medulloblastoma(224;0.235)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0178)														---	---	---	---
BMPR1A	657	broad.mit.edu	37	10	88614690	88614691	+	Intron	INS	-	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:88614690_88614691insT	uc001kdy.2	+							NM_004329	NP_004320			bone morphogenetic protein receptor, type IA						BMP signaling pathway|immune response|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	integral to membrane|plasma membrane	ATP binding|metal ion binding|protein homodimerization activity|SMAD binding|transforming growth factor beta receptor activity			lung(3)|large_intestine(1)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	8								Mis|N|F			gastrointestinal polyps			Hereditary_Mixed_Polyposis_syndrome_type_2|Juvenile_Polyposis				---	---	---	---
PLEKHA1	59338	broad.mit.edu	37	10	124189011	124189016	+	Intron	DEL	TGTGTG	-	-	rs140551676		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:124189011_124189016delTGTGTG	uc001lge.1	+						PLEKHA1_uc001lgf.1_Intron|PLEKHA1_uc001lgg.1_Intron	NM_001001974	NP_001001974			pleckstrin homology domain containing, family A						B cell receptor signaling pathway|cellular response to hydrogen peroxide|establishment of protein localization|negative regulation of protein kinase B signaling cascade|phosphatidylinositol 3-kinase cascade|ruffle organization	cytoplasm|nucleus|ruffle membrane	PDZ domain binding|phosphatidylinositol-3,4-bisphosphate binding			kidney(1)	1		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)																---	---	---	---
STK32C	282974	broad.mit.edu	37	10	134145421	134145421	+	Intron	DEL	C	-	-	rs71013521		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:134145421delC	uc009ybd.1	-						STK32C_uc010quu.1_5'Flank|STK32C_uc009ybc.1_5'Flank|LRRC27_uc001llf.2_5'Flank|LRRC27_uc010quv.1_5'Flank|LRRC27_uc010quw.1_5'Flank|LRRC27_uc001llg.2_5'Flank|LRRC27_uc001lli.2_5'Flank					Homo sapiens cDNA FLJ25120 fis, clone CBR06020.								ATP binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|breast(1)	5		all_cancers(35;2.72e-11)|all_epithelial(44;2.33e-08)|Lung NSC(174;0.000855)|all_lung(145;0.00146)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.112)|Melanoma(40;0.124)|Glioma(114;0.203)		Epithelial(32;3.99e-05)|all cancers(32;5.58e-05)|OV - Ovarian serous cystadenocarcinoma(35;9.96e-05)|BRCA - Breast invasive adenocarcinoma(275;0.222)														---	---	---	---
PDE3B	5140	broad.mit.edu	37	11	14854498	14854498	+	Intron	DEL	T	-	-	rs80137325		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:14854498delT	uc001mln.2	+						PDE3B_uc010rcr.1_Intron	NM_000922	NP_000913			phosphodiesterase 3B						cAMP catabolic process|insulin receptor signaling pathway|negative regulation of lipid catabolic process|platelet activation	cytosol|endoplasmic reticulum|Golgi apparatus|guanyl-nucleotide exchange factor complex|integral to membrane|microsome	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding|protein kinase B binding				0																		---	---	---	---
VWCE	220001	broad.mit.edu	37	11	61061648	61061648	+	Intron	DEL	G	-	-			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:61061648delG	uc001nra.2	-						VWCE_uc001nrb.2_Intron	NM_152718	NP_689931			von Willebrand factor C and EGF domains							extracellular region	calcium ion binding			ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	12	69594093	69594102	+	IGR	DEL	AGAAAGAGAT	-	-	rs80081772		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:69594093_69594102delAGAAAGAGAT								CPM (237073 upstream) : CPSF6 (39215 downstream)																																			---	---	---	---
SRRM4	84530	broad.mit.edu	37	12	119560094	119560097	+	Intron	DEL	AGGC	-	-	rs72486757	by1000genomes	TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:119560094_119560097delAGGC	uc001txa.1	+							NM_194286	NP_919262			KIAA1853 protein						cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			ovary(2)	2																		---	---	---	---
ZNF268	10795	broad.mit.edu	37	12	133764701	133764702	+	Intron	INS	-	T	T	rs112587939		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:133764701_133764702insT	uc010tcf.1	+						ZNF268_uc010tbv.1_Intron|ZNF268_uc010tbw.1_Intron|ZNF268_uc010tbx.1_Intron|ZNF268_uc010tby.1_Intron|ZNF268_uc010tbz.1_Intron|ZNF268_uc010tca.1_Intron|ZNF268_uc010tcb.1_Intron|ZNF268_uc010tcc.1_Intron|ZNF268_uc010tcd.1_Intron|ZNF268_uc010tce.1_Intron|ZNF268_uc010tcg.1_Intron|ZNF268_uc010tch.1_Intron	NM_003415	NP_003406			zinc finger protein 268 isoform a							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.000215)|all_epithelial(31;0.096)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)														---	---	---	---
KIAA0564	23078	broad.mit.edu	37	13	42306420	42306420	+	Intron	DEL	A	-	-			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:42306420delA	uc001uyj.2	-						KIAA0564_uc001uyk.2_Intron	NM_015058	NP_055873			hypothetical protein LOC23078 isoform a							extracellular region	ATP binding|ATPase activity			ovary(3)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	6		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)														---	---	---	---
NUSAP1	51203	broad.mit.edu	37	15	41672441	41672442	+	3'UTR	INS	-	T	T	rs34658531		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:41672441_41672442insT	uc001zns.3	+	11					NUSAP1_uc001znq.3_3'UTR|NUSAP1_uc001znr.3_3'UTR|NUSAP1_uc010bce.2_3'UTR|NUSAP1_uc001znt.3_3'UTR|NUSAP1_uc001znv.3_3'UTR|NUSAP1_uc001znu.3_3'UTR|NUSAP1_uc010ucw.1_3'UTR|NUSAP1_uc001znw.3_3'UTR	NM_016359	NP_057443			nucleolar and spindle associated protein 1						cytokinesis after mitosis|establishment of mitotic spindle localization|mitotic chromosome condensation|positive regulation of mitosis	chromosome|cytoplasm|nucleolus	DNA binding				0		all_cancers(109;5.07e-19)|all_epithelial(112;2.43e-16)|Lung NSC(122;1.81e-11)|all_lung(180;4.81e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;9.63e-17)|GBM - Glioblastoma multiforme(113;1.59e-06)|BRCA - Breast invasive adenocarcinoma(123;0.168)														---	---	---	---
PARP16	54956	broad.mit.edu	37	15	65563598	65563598	+	Intron	DEL	T	-	-			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:65563598delT	uc002aoo.2	-						PARP16_uc002aop.2_Intron|PARP16_uc002aoq.2_Intron	NM_017851	NP_060321			poly (ADP-ribose) polymerase family, member 16							integral to membrane	NAD+ ADP-ribosyltransferase activity			lung(2)	2																		---	---	---	---
SIN3A	25942	broad.mit.edu	37	15	75676889	75676890	+	Intron	INS	-	G	G	rs76016458		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:75676889_75676890insG	uc002bai.2	-						SIN3A_uc002baj.2_Intron|SIN3A_uc010uml.1_Intron	NM_015477	NP_056292			transcriptional co-repressor Sin3A						blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			skin(3)|ovary(1)|lung(1)	5																		---	---	---	---
ATF7IP2	80063	broad.mit.edu	37	16	10532277	10532277	+	Intron	DEL	T	-	-			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:10532277delT	uc002czu.2	+						ATF7IP2_uc002czv.2_Intron|ATF7IP2_uc010uyo.1_Intron|ATF7IP2_uc010uyp.1_Intron|ATF7IP2_uc002czw.2_Intron|ATF7IP2_uc010uyq.1_Intron	NM_024997	NP_079273			activating transcription factor 7 interacting						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0																		---	---	---	---
Unknown	0	broad.mit.edu	37	16	25031511	25031512	+	IGR	INS	-	GGAAGGAA	GGAAGGAA	rs7498498	by1000genomes	TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:25031511_25031512insGGAAGGAA								ARHGAP17 (4836 upstream) : LCMT1 (91535 downstream)																																			---	---	---	---
BBS2	583	broad.mit.edu	37	16	56532618	56532619	+	Intron	INS	-	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:56532618_56532619insA	uc002ejd.2	-						BBS2_uc010ccg.2_3'UTR	NM_031885	NP_114091			Bardet-Biedl syndrome 2 protein						adult behavior|brain morphogenesis|cerebral cortex development|cilium morphogenesis|fat cell differentiation|hippocampus development|melanosome transport|negative regulation of multicellular organism growth|photoreceptor cell maintenance|protein localization to organelle|regulation of cilium beat frequency involved in ciliary motility|sperm axoneme assembly|striatum development	BBSome|cilium membrane|microtubule basal body|motile cilium	protein binding			ovary(1)	1														Bardet-Biedl_syndrome				---	---	---	---
MYO1C	4641	broad.mit.edu	37	17	1386000	1386001	+	Intron	INS	-	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:1386000_1386001insC	uc002fsp.2	-						MYO1C_uc002fsn.2_Intron|MYO1C_uc002fso.2_Intron|MYO1C_uc010vqj.1_Intron|MYO1C_uc010vqk.1_Intron	NM_001080779	NP_001074248			myosin IC isoform a						mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)														---	---	---	---
Unknown	0	broad.mit.edu	37	17	6464640	6464641	+	IGR	INS	-	CTC	CTC	rs143155894	by1000genomes	TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:6464640_6464641insCTC								PITPNM3 (4763 upstream) : KIAA0753 (17005 downstream)																																			---	---	---	---
RGL3	57139	broad.mit.edu	37	19	11495173	11495174	+	3'UTR	INS	-	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:11495173_11495174insT	uc002mrn.2	-	19					EPOR_uc002mri.2_5'Flank|EPOR_uc002mrk.1_5'Flank|EPOR_uc002mrl.1_5'Flank|EPOR_uc002mrj.1_5'Flank|EPOR_uc010xlx.1_5'Flank|EPOR_uc010xly.1_5'Flank|RGL3_uc002mrm.2_3'UTR					SubName: Full=FLJ00153 protein; Flags: Fragment;						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular				ovary(1)	1																		---	---	---	---
CKM	1158	broad.mit.edu	37	19	45811507	45811507	+	Intron	DEL	G	-	-	rs17875626		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:45811507delG	uc002pbd.2	-							NM_001824	NP_001815			muscle creatine kinase						creatine metabolic process	cytosol	ATP binding|creatine kinase activity			skin(1)	1		Ovarian(192;0.0336)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;2.29e-44)|Epithelial(262;1.05e-38)|GBM - Glioblastoma multiforme(486;3.56e-07)	Creatine(DB00148)													---	---	---	---
Unknown	0	broad.mit.edu	37	20	25079675	25079675	+	IGR	DEL	G	-	-			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:25079675delG								VSX1 (16908 upstream) : LOC284798 (41759 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	21	44755961	44755961	+	IGR	DEL	C	-	-			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:44755961delC								CRYAA (163048 upstream) : SIK1 (78437 downstream)																																			---	---	---	---
RPS26P11	441502	broad.mit.edu	37	X	71264809	71264810	+	3'UTR	INS	-	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:71264809_71264810insA	uc004eai.2	+	1					NHSL2_uc011mqa.1_Intron	NR_002309				Homo sapiens ribosomal protein S26 pseudogene 11 (RPS26P11), non-coding RNA.												0																		---	---	---	---
Unknown	0	broad.mit.edu	37	Y	28780698	28780699	+	IGR	INS	-	AG	AG			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrY:28780698_28780699insAG								None (None upstream) : None (None downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	1	61509502	61509503	+	IGR	DEL	AC	-	-	rs71830791		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:61509502_61509503delAC								C1orf87 (970076 upstream) : NFIA (33443 downstream)																																			---	---	---	---
LRIG2	9860	broad.mit.edu	37	1	113666345	113666346	+	Intron	INS	-	TTTTTT	TTTTTT	rs139220276	by1000genomes	TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:113666345_113666346insTTTTTT	uc001edf.1	+						LRIG2_uc009wgn.1_Intron	NM_014813	NP_055628			leucine-rich repeats and immunoglobulin-like							cytoplasm|integral to membrane|plasma membrane				ovary(3)	3	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)														---	---	---	---
CGN	57530	broad.mit.edu	37	1	151506277	151506277	+	Intron	DEL	A	-	-			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:151506277delA	uc009wmw.2	+						CGN_uc010pde.1_5'Flank	NM_020770	NP_065821			cingulin							myosin complex|tight junction	actin binding|motor activity			ovary(2)|pancreas(1)	3	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)															---	---	---	---
Unknown	0	broad.mit.edu	37	2	89472134	89472135	+	Intron	INS	-	GT	GT	rs144800922	by1000genomes	TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:89472134_89472135insGT	uc010ytr.1	-						uc002stl.2_Intron					Parts of antibodies, mostly variable regions.																														---	---	---	---
Unknown	0	broad.mit.edu	37	2	114424982	114424985	+	IGR	DEL	TTTA	-	-			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:114424982_114424985delTTTA								RABL2A (24008 upstream) : SLC35F5 (46946 downstream)																																			---	---	---	---
USP4	7375	broad.mit.edu	37	3	49364972	49364972	+	Intron	DEL	A	-	-			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49364972delA	uc003cwq.2	-						USP4_uc003cwr.2_Intron	NM_003363	NP_003354			ubiquitin specific protease 4 isoform a						negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|urinary_tract(1)|lung(1)	4		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)														---	---	---	---
Unknown	0	broad.mit.edu	37	3	195378243	195378243	+	Intron	DEL	T	-	-			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:195378243delT	uc011bta.1	-											Homo sapiens, clone IMAGE:5171739, mRNA.																														---	---	---	---
SORCS2	57537	broad.mit.edu	37	4	7726580	7726581	+	Intron	INS	-	TTA	TTA	rs147507704	by1000genomes	TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:7726580_7726581insTTA	uc003gkb.3	+						SORCS2_uc011bwi.1_Intron	NM_020777	NP_065828			VPS10 domain receptor protein SORCS 2 precursor							integral to membrane	neuropeptide receptor activity			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
FRYL	285527	broad.mit.edu	37	4	48625213	48625213	+	Intron	DEL	C	-	-	rs776579	by1000genomes	TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:48625213delC	uc003gyh.1	-						FRYL_uc003gyk.2_Intron|FRYL_uc003gyl.1_Intron|FRYL_uc003gym.1_Intron	NM_015030	NP_055845			furry-like						regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1																		---	---	---	---
RPS3A	6189	broad.mit.edu	37	4	152025591	152025592	+	Intron	INS	-	TTT	TTT	rs13111229		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:152025591_152025592insTTT	uc003ilz.2	+							NM_001006	NP_000997			ribosomal protein S3a						cell differentiation|endocrine pancreas development|induction of apoptosis|translational elongation|translational initiation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome			ovary(1)	1	all_hematologic(180;0.093)																	---	---	---	---
WWC2	80014	broad.mit.edu	37	4	184114632	184114633	+	Intron	INS	-	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:184114632_184114633insT	uc010irx.2	+						WWC2_uc003ivk.3_5'Flank	NM_024949	NP_079225			WW and C2 domain containing 2											ovary(2)|lung(1)	3		all_lung(41;5.28e-14)|Lung NSC(41;1.35e-13)|Colorectal(36;0.00681)|Hepatocellular(41;0.00886)|Renal(120;0.00992)|Prostate(90;0.0237)|all_hematologic(60;0.0592)|Esophageal squamous(56;0.179)|all_neural(102;0.202)		all cancers(43;3.38e-24)|Epithelial(43;1.4e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.09e-09)|GBM - Glioblastoma multiforme(59;3.33e-05)|Colorectal(24;3.58e-05)|STAD - Stomach adenocarcinoma(60;4.21e-05)|COAD - Colon adenocarcinoma(29;0.000171)|LUSC - Lung squamous cell carcinoma(40;0.0145)|READ - Rectum adenocarcinoma(43;0.242)														---	---	---	---
Unknown	0	broad.mit.edu	37	4	189192022	189192023	+	IGR	INS	-	CAG	CAG	rs138764960	by1000genomes	TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:189192022_189192023insCAG								TRIML1 (123373 upstream) : None (None downstream)																																			---	---	---	---
MDN1	23195	broad.mit.edu	37	6	90409616	90409616	+	Intron	DEL	A	-	-			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:90409616delA	uc003pnn.1	-							NM_014611	NP_055426			MDN1, midasin homolog						protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)														---	---	---	---
Unknown	0	broad.mit.edu	37	7	63023116	63023116	+	IGR	DEL	C	-	-			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:63023116delC								LOC100287704 (210965 upstream) : ZNF727 (482705 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	7	98409190	98409190	+	IGR	DEL	T	-	-	rs112577704		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:98409190delT								NPTX2 (150009 upstream) : TMEM130 (34922 downstream)																																			---	---	---	---
DOCK4	9732	broad.mit.edu	37	7	111474750	111474750	+	Intron	DEL	A	-	-			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:111474750delA	uc003vfx.2	-						DOCK4_uc003vfw.2_Intron|DOCK4_uc003vfy.2_Intron	NM_014705	NP_055520			dedicator of cytokinesis 4						cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)																---	---	---	---
Unknown	0	broad.mit.edu	37	9	66545695	66545695	+	Intron	DEL	A	-	-			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:66545695delA	uc010mnh.1	-						uc004aef.2_Intron					Homo sapiens cDNA FLJ20444 fis, clone KAT05128.																														---	---	---	---
Unknown	0	broad.mit.edu	37	9	91131649	91131650	+	IGR	INS	-	TTCCTTCC	TTCCTTCC	rs62580715		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:91131649_91131650insTTCCTTCC								SPIN1 (38029 upstream) : NXNL2 (18366 downstream)																																			---	---	---	---
IARS	3376	broad.mit.edu	37	9	94985154	94985154	+	Intron	DEL	A	-	-			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:94985154delA	uc004art.1	-						IARS_uc004ars.1_Intron|IARS_uc004aru.3_Intron|IARS_uc010mqr.2_Intron|IARS_uc010mqt.2_Intron	NM_013417	NP_038203			isoleucine tRNA synthetase						isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			ovary(1)|skin(1)	2					L-Isoleucine(DB00167)													---	---	---	---
TTF1	7270	broad.mit.edu	37	9	135273373	135273373	+	Intron	DEL	A	-	-			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:135273373delA	uc004cbl.2	-						TTF1_uc011mcp.1_Intron|TTF1_uc004cbm.2_Intron	NM_007344	NP_031370			transcription termination factor, RNA polymerase						negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)														---	---	---	---
VWCE	220001	broad.mit.edu	37	11	61061648	61061648	+	Intron	DEL	G	-	-			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:61061648delG	uc001nra.2	-						VWCE_uc001nrb.2_Intron	NM_152718	NP_689931			von Willebrand factor C and EGF domains							extracellular region	calcium ion binding			ovary(1)	1																		---	---	---	---
MTL5	9633	broad.mit.edu	37	11	68518237	68518251	+	Intron	DEL	CAGCCAAGGGAGGGG	-	-			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:68518237_68518251delCAGCCAAGGGAGGGG	uc001ooc.2	-						MTL5_uc001ood.1_Intron|MTL5_uc009ysi.1_Intron|MTL5_uc001ooe.2_5'Flank	NM_004923	NP_004914			metallothionein-like 5, testis-specific isoform						cell differentiation|cellular metal ion homeostasis|multicellular organismal development|response to metal ion|spermatogenesis	cytoplasm|nucleus|soluble fraction	metal ion binding			ovary(2)|breast(1)	3	Esophageal squamous(3;4.37e-12)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.185)															---	---	---	---
KDM5A	5927	broad.mit.edu	37	12	415910	415910	+	Intron	DEL	A	-	-			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:415910delA	uc001qif.1	-						KDM5A_uc001qie.1_Intron	NM_001042603	NP_001036068			retinoblastoma binding protein 2 isoform 1						chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|ovary(1)	3								T 	NUP98	AML								---	---	---	---
DDX12	440081	broad.mit.edu	37	12	9590500	9590501	+	Intron	INS	-	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:9590500_9590501insC	uc010sgs.1	-						DDX12_uc009zgq.1_5'Flank	NM_004400	NP_004391			DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12												0																		---	---	---	---
GRIP1	23426	broad.mit.edu	37	12	66957911	66957911	+	Intron	DEL	T	-	-			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:66957911delT	uc001stk.2	-						GRIP1_uc010sta.1_Intron|GRIP1_uc001stl.1_Intron|GRIP1_uc001stm.2_Intron	NM_021150	NP_066973			glutamate receptor interacting protein 1						androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			ovary(2)	2			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)														---	---	---	---
KIAA0564	23078	broad.mit.edu	37	13	42306420	42306420	+	Intron	DEL	A	-	-			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:42306420delA	uc001uyj.2	-						KIAA0564_uc001uyk.2_Intron	NM_015058	NP_055873			hypothetical protein LOC23078 isoform a							extracellular region	ATP binding|ATPase activity			ovary(3)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	6		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)														---	---	---	---
SUGT1	10910	broad.mit.edu	37	13	53239647	53239648	+	Intron	INS	-	TAGT	TAGT	rs150887268	by1000genomes	TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:53239647_53239648insTAGT	uc001vhc.2	+						SUGT1_uc001vha.2_Intron|SUGT1_uc001vhb.2_Intron|SUGT1_uc010thb.1_Intron|SUGT1_uc001vhd.2_Intron	NM_001130912	NP_001124384			suppressor of G2 allele of SKP1 isoform a						mitosis	kinetochore|ubiquitin ligase complex	binding				0		Lung NSC(96;0.00212)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.25e-08)														---	---	---	---
Unknown	0	broad.mit.edu	37	13	114025775	114025775	+	IGR	DEL	C	-	-			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:114025775delC								GRTP1 (7312 upstream) : ADPRHL1 (50485 downstream)																																			---	---	---	---
NRXN3	9369	broad.mit.edu	37	14	79723887	79723888	+	Intron	INS	-	TGA	TGA			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:79723887_79723888insTGA	uc001xun.2	+						NRXN3_uc001xum.1_Intron	NM_004796	NP_004787			neurexin 3 isoform 1 precursor						axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)														---	---	---	---
CKMT1A	548596	broad.mit.edu	37	15	43990707	43990707	+	Intron	DEL	A	-	-			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:43990707delA	uc001zsn.2	+						CKMT1A_uc010uea.1_Intron|CKMT1A_uc001zso.3_Intron	NM_001015001	NP_001015001			creatine kinase, mitochondrial 1A precursor						creatine metabolic process	mitochondrial inner membrane	ATP binding|creatine kinase activity				0		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)	Creatine(DB00148)													---	---	---	---
Unknown	0	broad.mit.edu	37	15	75544855	75544855	+	IGR	DEL	T	-	-	rs138336820		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:75544855delT								C15orf39 (40347 upstream) : GOLGA6C (6044 downstream)																																			---	---	---	---
BBS2	583	broad.mit.edu	37	16	56532618	56532619	+	Intron	INS	-	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:56532618_56532619insA	uc002ejd.2	-						BBS2_uc010ccg.2_3'UTR	NM_031885	NP_114091			Bardet-Biedl syndrome 2 protein						adult behavior|brain morphogenesis|cerebral cortex development|cilium morphogenesis|fat cell differentiation|hippocampus development|melanosome transport|negative regulation of multicellular organism growth|photoreceptor cell maintenance|protein localization to organelle|regulation of cilium beat frequency involved in ciliary motility|sperm axoneme assembly|striatum development	BBSome|cilium membrane|microtubule basal body|motile cilium	protein binding			ovary(1)	1														Bardet-Biedl_syndrome				---	---	---	---
SPATA2L	124044	broad.mit.edu	37	16	89764881	89764882	+	Intron	DEL	TC	-	-			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:89764881_89764882delTC	uc002foj.2	-						SPATA2L_uc002fok.2_Intron	NM_152339	NP_689552			spermatogenesis associated 2-like												0		Lung NSC(15;0.00043)|all_lung(18;0.000665)|all_hematologic(23;0.0355)		BRCA - Breast invasive adenocarcinoma(80;0.0272)														---	---	---	---
ATP2A3	489	broad.mit.edu	37	17	3854837	3854838	+	Intron	INS	-	C	C	rs144318844	by1000genomes	TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:3854837_3854838insC	uc002fxb.1	-						ATP2A3_uc002fwx.1_Intron|ATP2A3_uc002fwy.1_Intron|ATP2A3_uc002fwz.1_Intron|ATP2A3_uc002fxa.1_Intron|ATP2A3_uc002fxc.1_Intron|ATP2A3_uc002fxd.1_Intron	NM_174955	NP_777615			ATPase, Ca++ transporting, ubiquitous isoform b						ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			ovary(3)|breast(1)|central_nervous_system(1)	5				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)														---	---	---	---
Unknown	0	broad.mit.edu	37	17	6464640	6464641	+	IGR	INS	-	CTC	CTC	rs143155894	by1000genomes	TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:6464640_6464641insCTC								PITPNM3 (4763 upstream) : KIAA0753 (17005 downstream)																																			---	---	---	---
MLLT6	4302	broad.mit.edu	37	17	36881873	36881873	+	3'UTR	DEL	C	-	-			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:36881873delC	uc002hqi.3	+	20					MLLT6_uc002hqk.3_3'UTR|MLLT6_uc010cvn.1_5'Flank	NM_005937	NP_005928			myeloid/lymphoid or mixed-lineage leukemia						regulation of transcription, DNA-dependent	nucleus	protein binding|zinc ion binding			breast(3)|prostate(1)|lung(1)|skin(1)	6	Breast(7;4.43e-21)							T	MLL	AL								---	---	---	---
FAM134C	162427	broad.mit.edu	37	17	40734988	40734988	+	Intron	DEL	T	-	-	rs35747013		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40734988delT	uc002ial.2	-						FAM134C_uc010wgq.1_Intron|FAM134C_uc002iam.1_Intron|FAM134C_uc010cyk.1_Intron	NM_178126	NP_835227			hypothetical protein LOC162427							integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.134)														---	---	---	---
Unknown	0	broad.mit.edu	37	18	214519	214520	+	IGR	INS	-	TTG	TTG	rs142588910		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:214519_214520insTTG								USP14 (780 upstream) : THOC1 (2 downstream)																																			---	---	---	---
VAV1	7409	broad.mit.edu	37	19	6832628	6832629	+	Intron	INS	-	TCG	TCG	rs61665765		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6832628_6832629insTCG	uc002mfu.1	+						VAV1_uc010xjh.1_Intron|VAV1_uc010dva.1_Intron|VAV1_uc002mfv.1_Intron	NM_005428	NP_005419			vav 1 guanine nucleotide exchange factor						apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(4)|ovary(4)|breast(3)|central_nervous_system(2)|kidney(2)|skin(1)	16																		---	---	---	---
PLVAP	83483	broad.mit.edu	37	19	17471724	17471724	+	Intron	DEL	T	-	-			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17471724delT	uc002ngk.1	-							NM_031310	NP_112600			plasmalemma vesicle associated protein							caveola|integral to membrane|perinuclear region of cytoplasm					0																		---	---	---	---
ZNF98	148198	broad.mit.edu	37	19	22583906	22583906	+	Intron	DEL	A	-	-			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:22583906delA	uc002nqt.2	-							NM_001098626	NP_001092096			zinc finger protein 98						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)																---	---	---	---
SLC7A9	11136	broad.mit.edu	37	19	33351376	33351377	+	Intron	INS	-	A	A	rs5827823		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:33351376_33351377insA	uc002ntv.3	-						SLC7A9_uc002ntt.3_Intron|SLC7A9_uc002ntu.3_Intron|SLC7A9_uc002ntw.3_5'UTR	NM_001126335	NP_001119807			solute carrier family 7, member 9						blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	integral to plasma membrane	L-cystine transmembrane transporter activity|neutral amino acid transmembrane transporter activity|peptide antigen binding			skin(1)	1	Esophageal squamous(110;0.137)				L-Cystine(DB00138)													---	---	---	---
CLC	1178	broad.mit.edu	37	19	40226832	40226833	+	Intron	INS	-	A	A	rs112910859		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:40226832_40226833insA	uc002omh.2	-							NM_001828	NP_001819			Charcot-Leyden crystal protein						lipid catabolic process|multicellular organismal development		carboxylesterase activity|lysophospholipase activity|sugar binding				0	all_cancers(60;2.99e-06)|all_lung(34;4.7e-08)|Lung NSC(34;5.46e-08)|Ovarian(47;0.06)	Renal(1328;0.000147)|Hepatocellular(1079;0.0202)|Myeloproliferative disorder(2;0.0255)	Epithelial(26;6.43e-25)|OV - Ovarian serous cystadenocarcinoma(5;1.07e-24)|all cancers(26;8.38e-23)	GBM - Glioblastoma multiforme(1328;4.97e-06)|STAD - Stomach adenocarcinoma(1328;0.00655)														---	---	---	---
Unknown	0	broad.mit.edu	37	19	54637487	54637488	+	IGR	INS	-	CT	CT			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54637487_54637488insCT								PRPF31 (2337 upstream) : CNOT3 (3961 downstream)																																			---	---	---	---
ZNF335	63925	broad.mit.edu	37	20	44586694	44586695	+	Intron	INS	-	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:44586694_44586695insT	uc002xqw.2	-						ZNF335_uc010zxk.1_Intron	NM_022095	NP_071378			zinc finger protein 335						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|ovary(1)	4		Myeloproliferative disorder(115;0.0122)																---	---	---	---
DOPEY2	9980	broad.mit.edu	37	21	37619142	37619151	+	Intron	DEL	TTATGTTATG	-	-	rs67162183		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:37619142_37619151delTTATGTTATG	uc002yvg.2	+						DOPEY2_uc011aeb.1_Intron|DOPEY2_uc002yvh.2_Intron	NM_005128	NP_005119			pad-1-like						endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2																		---	---	---	---
DYRK1A	1859	broad.mit.edu	37	21	38845339	38845339	+	Intron	DEL	T	-	-			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:38845339delT	uc002ywk.2	+						DYRK1A_uc002ywh.1_Intron|DYRK1A_uc002ywi.2_Intron|DYRK1A_uc002ywj.2_Intron|DYRK1A_uc002ywl.2_Intron|DYRK1A_uc002ywm.2_Intron	NM_001396	NP_001387			dual-specificity tyrosine-(Y)-phosphorylation						nervous system development|peptidyl-tyrosine phosphorylation|protein autophosphorylation	nuclear speck	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding|protein self-association|protein serine/threonine kinase activity			ovary(2)|lung(1)|breast(1)	4																		---	---	---	---
Unknown	0	broad.mit.edu	37	21	44755961	44755961	+	IGR	DEL	C	-	-			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:44755961delC								CRYAA (163048 upstream) : SIK1 (78437 downstream)																																			---	---	---	---
APOL2	23780	broad.mit.edu	37	22	36634521	36634523	+	Intron	DEL	TCA	-	-	rs3075427		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:36634521_36634523delTCA	uc003aoz.2	-						APOL2_uc011amm.1_Intron|APOL2_uc003apa.2_Intron|uc003apb.1_RNA	NM_030882	NP_112092			apolipoprotein L2						acute-phase response|cholesterol metabolic process|lipid transport|lipoprotein metabolic process|maternal process involved in female pregnancy|multicellular organismal development	endoplasmic reticulum membrane|extracellular region	high-density lipoprotein particle binding|lipid binding|receptor binding				0																		---	---	---	---
COL4A6	1288	broad.mit.edu	37	X	107415595	107415596	+	Intron	INS	-	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:107415595_107415596insA	uc004enw.3	-						COL4A6_uc004env.3_Intron|COL4A6_uc011msn.1_Intron|COL4A6_uc010npk.2_Intron	NM_001847	NP_001838			type IV alpha 6 collagen isoform A precursor						cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(6)|urinary_tract(1)|large_intestine(1)	8														Alport_syndrome_with_Diffuse_Leiomyomatosis				---	---	---	---
MEGF6	1953	broad.mit.edu	37	1	3427384	3427384	+	Silent	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:3427384G>A	uc001akl.2	-	10	1424	c.1197C>T	c.(1195-1197)GCC>GCT	p.A399A	MEGF6_uc001akk.2_Silent_p.A294A	NM_001409	NP_001400	O75095	MEGF6_HUMAN	EGF-like-domain, multiple 3 precursor	399	EGF-like 7.					extracellular region	calcium ion binding			large_intestine(1)	1	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)														---	---	---	---
PER3	8863	broad.mit.edu	37	1	7886602	7886602	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:7886602T>C	uc001aoo.2	+	16	2171	c.1996T>C	c.(1996-1998)TCG>CCG	p.S666P	PER3_uc009vmg.1_Missense_Mutation_p.S674P|PER3_uc009vmh.1_Missense_Mutation_p.S667P|PER3_uc001aop.2_Missense_Mutation_p.S674P|PER3_uc010nzw.1_Missense_Mutation_p.S355P	NM_016831	NP_058515	P56645	PER3_HUMAN	period 3	666	CSNK1E binding domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			ovary(1)|pancreas(1)|skin(1)	3	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
PRAMEF1	65121	broad.mit.edu	37	1	12855688	12855688	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:12855688A>C	uc001auj.1	+	4	1071	c.968A>C	c.(967-969)AAG>ACG	p.K323T		NM_023013	NP_075389	O95521	PRAM1_HUMAN	PRAME family member 1	323	LRR 1.										0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
DLGAP3	58512	broad.mit.edu	37	1	35369893	35369893	+	Silent	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:35369893A>G	uc001byc.2	-	1	1092	c.1092T>C	c.(1090-1092)ACT>ACC	p.T364T		NM_001080418	NP_001073887	O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated	364					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				ovary(3)	3		Myeloproliferative disorder(586;0.0393)																---	---	---	---
MRPS15	64960	broad.mit.edu	37	1	36926911	36926911	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:36926911A>G	uc001cas.2	-	4	418	c.254T>C	c.(253-255)GTT>GCT	p.V85A		NM_031280	NP_112570	P82914	RT15_HUMAN	mitochondrial ribosomal protein S15 precursor	85					translation	mitochondrial small ribosomal subunit|nuclear membrane	structural constituent of ribosome			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)																---	---	---	---
ZNF643	65243	broad.mit.edu	37	1	40929053	40929053	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:40929053A>G	uc001cfn.1	+	5	1694	c.1397A>G	c.(1396-1398)CAG>CGG	p.Q466R	ZNF643_uc001cfl.1_Missense_Mutation_p.Q364R|ZNF643_uc001cfm.1_Missense_Mutation_p.Q332R	NM_023070	NP_075558	Q9UJL9	ZN643_HUMAN	zinc finger protein 643	466	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;5.25e-18)															---	---	---	---
PGM1	5236	broad.mit.edu	37	1	64100648	64100648	+	Silent	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:64100648G>A	uc001dbh.2	+	5	1044	c.831G>A	c.(829-831)AAG>AAA	p.K277K	PGM1_uc010ooy.1_Silent_p.K80K|PGM1_uc010ooz.1_Silent_p.K295K	NM_002633	NP_002624	P36871	PGM1_HUMAN	phosphoglucomutase 1	277					cellular calcium ion homeostasis|galactose catabolic process|glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity			ovary(2)|kidney(1)	3																		---	---	---	---
WDR63	126820	broad.mit.edu	37	1	85551632	85551632	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:85551632A>C	uc001dkt.2	+	7	850	c.659A>C	c.(658-660)AAT>ACT	p.N220T	WDR63_uc009wcl.2_Missense_Mutation_p.N220T	NM_145172	NP_660155	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	220										upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)														---	---	---	---
COL24A1	255631	broad.mit.edu	37	1	86227202	86227202	+	Intron	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:86227202A>C	uc001dlj.2	-						COL24A1_uc001dli.2_Intron|COL24A1_uc010osd.1_Intron|COL24A1_uc001dlk.2_Intron|COL24A1_uc010ose.1_Intron|COL24A1_uc010osf.1_Intron	NM_152890	NP_690850			collagen, type XXIV, alpha 1 precursor						cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)														---	---	---	---
NGF	4803	broad.mit.edu	37	1	115828920	115828920	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:115828920T>G	uc001efu.1	-	3	666	c.497A>C	c.(496-498)AAC>ACC	p.N166T		NM_002506	NP_002497	P01138	NGF_HUMAN	nerve growth factor, beta polypeptide precursor	166					activation of MAPKK activity|activation of phospholipase C activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of cell cycle|nerve growth factor processing|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|Golgi lumen	growth factor activity|nerve growth factor receptor binding			upper_aerodigestive_tract(2)	2	Lung SC(450;0.211)	all_cancers(81;1.07e-06)|all_epithelial(167;4.43e-06)|all_lung(203;2.86e-05)|Lung NSC(69;4.99e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)	Clenbuterol(DB01407)													---	---	---	---
POGZ	23126	broad.mit.edu	37	1	151384863	151384863	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:151384863T>G	uc001eyd.1	-	11	1994	c.1688A>C	c.(1687-1689)AAG>ACG	p.K563T	POGZ_uc001eye.1_Missense_Mutation_p.K510T|POGZ_uc010pdb.1_Missense_Mutation_p.K554T|POGZ_uc001eyf.1_Missense_Mutation_p.K510T|POGZ_uc010pdc.1_Missense_Mutation_p.K501T|POGZ_uc009wmv.1_Missense_Mutation_p.K468T|POGZ_uc010pdd.1_Missense_Mutation_p.K54T	NM_015100	NP_055915	Q7Z3K3	POGZ_HUMAN	pogo transposable element with ZNF domain	563	C2H2-type 4.				cell division|kinetochore assembly|mitotic sister chromatid cohesion|regulation of transcription, DNA-dependent	cytoplasm|nuclear chromatin	DNA binding|protein binding|zinc ion binding			ovary(3)	3	Lung SC(34;0.00471)|Ovarian(49;0.00672)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)															---	---	---	---
TCHH	7062	broad.mit.edu	37	1	152080591	152080591	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:152080591C>T	uc001ezp.2	-	2	5102	c.5102G>A	c.(5101-5103)CGC>CAC	p.R1701H	TCHH_uc009wne.1_Missense_Mutation_p.R1701H	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1701	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)															---	---	---	---
SH2D2A	9047	broad.mit.edu	37	1	156779580	156779580	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156779580A>G	uc001fqd.2	-	6	727	c.587T>C	c.(586-588)CTT>CCT	p.L196P	SH2D2A_uc001fqc.1_Missense_Mutation_p.L168P|SH2D2A_uc009wsh.2_Missense_Mutation_p.L206P|SH2D2A_uc001fqe.2_Missense_Mutation_p.L178P|SH2D2A_uc010phs.1_Missense_Mutation_p.L196P	NM_003975	NP_003966	Q9NP31	SH22A_HUMAN	SH2 domain protein 2A isoform 2	196	Pro-rich.				angiogenesis|cell differentiation|signal transduction	cytoplasm|soluble fraction	SH3 domain binding|SH3/SH2 adaptor activity				0	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)																	---	---	---	---
FCRL3	115352	broad.mit.edu	37	1	157668201	157668201	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:157668201C>T	uc001frb.2	-	4	563	c.271G>A	c.(271-273)GAT>AAT	p.D91N	FCRL3_uc001fqx.3_RNA|FCRL3_uc001fqy.3_RNA|FCRL3_uc001fqz.3_Missense_Mutation_p.D91N|FCRL3_uc009wsn.2_RNA|FCRL3_uc009wso.2_RNA|FCRL3_uc001fra.2_5'Flank|FCRL3_uc001frc.1_Missense_Mutation_p.D91N	NM_052939	NP_443171	Q96P31	FCRL3_HUMAN	Fc receptor-like 3 precursor	91	Ig-like C2-type 1.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(1)	4	all_hematologic(112;0.0378)																	---	---	---	---
TAGLN2	8407	broad.mit.edu	37	1	159888742	159888742	+	Intron	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:159888742A>G	uc001fum.1	-						CCDC19_uc001ful.2_Intron|TAGLN2_uc001fun.1_Intron|TAGLN2_uc001fuo.1_3'UTR	NM_003564	NP_003555			transgelin 2						muscle organ development	nuclear membrane|plasma membrane	protein binding				0	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.111)															---	---	---	---
GPATCH2	55105	broad.mit.edu	37	1	217793304	217793304	+	Silent	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:217793304G>A	uc001hlf.1	-	2	690	c.594C>T	c.(592-594)GCC>GCT	p.A198A	GPATCH2_uc001hlg.3_Silent_p.A198A	NM_018040	NP_060510	Q9NW75	GPTC2_HUMAN	G patch domain containing 2	198						intracellular	nucleic acid binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0397)|all cancers(67;0.0744)|GBM - Glioblastoma multiforme(131;0.0872)														---	---	---	---
ZP4	57829	broad.mit.edu	37	1	238049070	238049070	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:238049070A>C	uc001hym.2	-	7	956	c.956T>G	c.(955-957)CTT>CGT	p.L319R	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	319	ZP.|Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)															---	---	---	---
OR2L8	391190	broad.mit.edu	37	1	248113081	248113081	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:248113081T>C	uc001idt.1	+	1	922	c.922T>C	c.(922-924)TGC>CGC	p.C308R	OR2L13_uc001ids.2_Intron	NM_001001963	NP_001001963	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L,	308	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)															---	---	---	---
ZNF672	79894	broad.mit.edu	37	1	249142475	249142475	+	Silent	SNP	G	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:249142475G>T	uc001iex.2	+	4	1697	c.1002G>T	c.(1000-1002)ACG>ACT	p.T334T		NM_024836	NP_079112	Q499Z4	ZN672_HUMAN	zinc finger protein 672	334					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)															---	---	---	---
IL1R2	7850	broad.mit.edu	37	2	102625053	102625053	+	Missense_Mutation	SNP	G	A	A	rs148522700		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:102625053G>A	uc002tbm.2	+	2	245	c.16G>A	c.(16-18)GTG>ATG	p.V6M	IL1R2_uc002tbn.2_Missense_Mutation_p.V6M|IL1R2_uc002tbo.1_Missense_Mutation_p.V6M	NM_004633	NP_004624	P27930	IL1R2_HUMAN	interleukin 1 receptor, type II precursor	6					immune response	integral to membrane|plasma membrane	interleukin-1, Type II, blocking receptor activity			ovary(1)|breast(1)	2					Anakinra(DB00026)													---	---	---	---
EDAR	10913	broad.mit.edu	37	2	109513596	109513596	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:109513596T>G	uc002teq.3	-	12	1545	c.1114A>C	c.(1114-1116)AAA>CAA	p.K372Q	EDAR_uc010fjn.2_Missense_Mutation_p.K404Q|EDAR_uc010yws.1_Missense_Mutation_p.K404Q	NM_022336	NP_071731	Q9UNE0	EDAR_HUMAN	ectodysplasin A receptor precursor	372	Death.|Cytoplasmic (Potential).				apoptosis|cell differentiation	integral to membrane	protein binding|transmembrane receptor activity			skin(1)	1																		---	---	---	---
DPP10	57628	broad.mit.edu	37	2	115200414	115200414	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:115200414A>G	uc002tla.1	+	1	516	c.59A>G	c.(58-60)AAG>AGG	p.K20R		NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	20	Mediates effects on KCND2.|Cytoplasmic (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10																		---	---	---	---
CCDC93	54520	broad.mit.edu	37	2	118698836	118698836	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:118698836T>C	uc002tlj.2	-	19	1577	c.1451A>G	c.(1450-1452)AAG>AGG	p.K484R	CCDC93_uc010fld.1_Missense_Mutation_p.K484R	NM_019044	NP_061917	Q567U6	CCD93_HUMAN	coiled-coil domain containing 93	484										large_intestine(1)|ovary(1)	2																		---	---	---	---
MGAT5	4249	broad.mit.edu	37	2	135206285	135206285	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:135206285A>C	uc002ttv.1	+	16	2238	c.2093A>C	c.(2092-2094)AAG>ACG	p.K698T	LOC151162_uc002ttw.3_5'Flank	NM_002410	NP_002401	Q09328	MGT5A_HUMAN	N-acetylglucosaminyltransferase V	698	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity			ovary(2)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.0964)														---	---	---	---
THSD7B	80731	broad.mit.edu	37	2	138208477	138208477	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:138208477A>G	uc002tva.1	+	14	2929	c.2929A>G	c.(2929-2931)AGT>GGT	p.S977G	THSD7B_uc010zbj.1_Intron	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)														---	---	---	---
LRP1B	53353	broad.mit.edu	37	2	141625218	141625218	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:141625218T>G	uc002tvj.1	-	27	5492	c.4520A>C	c.(4519-4521)CAG>CCG	p.Q1507P	LRP1B_uc010fnl.1_Missense_Mutation_p.Q689P	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1507	Extracellular (Potential).|LDL-receptor class B 13.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)											TSP Lung(27;0.18)			---	---	---	---
GCG	2641	broad.mit.edu	37	2	163000597	163000597	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:163000597A>G	uc002ucc.2	-	5	575	c.476T>C	c.(475-477)CTT>CCT	p.L159P		NM_002054	NP_002045	P01275	GLUC_HUMAN	glucagon preproprotein	159					cell proliferation|cellular response to glucagon stimulus|energy reserve metabolic process|feeding behavior|regulation of insulin secretion	plasma membrane|soluble fraction	hormone activity				0					Exenatide(DB01276)|Phentolamine(DB00692)													---	---	---	---
SCN2A	6326	broad.mit.edu	37	2	166165773	166165773	+	Intron	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:166165773A>C	uc002udc.2	+						SCN2A_uc002udd.2_Intron|SCN2A_uc002ude.2_Intron	NM_001040142	NP_001035232			sodium channel, voltage-gated, type II, alpha						myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)													---	---	---	---
CSRNP3	80034	broad.mit.edu	37	2	166535430	166535430	+	Missense_Mutation	SNP	G	A	A	rs141222366		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:166535430G>A	uc002udf.2	+	7	1301	c.925G>A	c.(925-927)GTA>ATA	p.V309I	CSRNP3_uc002udg.2_Missense_Mutation_p.V309I	NM_024969	NP_079245	Q8WYN3	CSRN3_HUMAN	cysteine-serine-rich nuclear protein 3	309					apoptosis|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|large_intestine(1)|skin(1)	5																		---	---	---	---
XIRP2	129446	broad.mit.edu	37	2	168100111	168100111	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:168100111G>A	uc002udx.2	+	8	2227	c.2209G>A	c.(2209-2211)GAA>AAA	p.E737K	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.E562K|XIRP2_uc010fpq.2_Missense_Mutation_p.E515K|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	562	Xin 6.				actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14																		---	---	---	---
TTN	7273	broad.mit.edu	37	2	179425966	179425966	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179425966C>T	uc010zfg.1	-	275	77413	c.77189G>A	c.(77188-77190)CGG>CAG	p.R25730Q	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R19425Q|TTN_uc010zfi.1_Missense_Mutation_p.R19358Q|TTN_uc010zfj.1_Missense_Mutation_p.R19233Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	26657							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179445318	179445318	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179445318A>C	uc010zfg.1	-	266	59308	c.59084T>G	c.(59083-59085)CTT>CGT	p.L19695R	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.L13390R|TTN_uc010zfi.1_Missense_Mutation_p.L13323R|TTN_uc010zfj.1_Missense_Mutation_p.L13198R|uc002umv.1_3'UTR	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	20622							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179452255	179452255	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179452255C>T	uc010zfg.1	-	255	56301	c.56077G>A	c.(56077-56079)GTC>ATC	p.V18693I	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V12388I|TTN_uc010zfi.1_Missense_Mutation_p.V12321I|TTN_uc010zfj.1_Missense_Mutation_p.V12196I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	19620							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179458569	179458569	+	Silent	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179458569T>C	uc010zfg.1	-	247	50978	c.50754A>G	c.(50752-50754)CCA>CCG	p.P16918P	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.P10613P|TTN_uc010zfi.1_Silent_p.P10546P|TTN_uc010zfj.1_Silent_p.P10421P	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17845							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
PLCL1	5334	broad.mit.edu	37	2	198950584	198950584	+	Silent	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:198950584T>C	uc010fsp.2	+	2	2634	c.2343T>C	c.(2341-2343)ACT>ACC	p.T781T	PLCL1_uc002uuv.3_Silent_p.T702T	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	781	C2.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)													---	---	---	---
IKZF2	22807	broad.mit.edu	37	2	213878645	213878645	+	Silent	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:213878645T>C	uc002vem.2	-	7	895	c.726A>G	c.(724-726)GAA>GAG	p.E242E	IKZF2_uc010fuu.2_Silent_p.E97E|IKZF2_uc002vej.2_Silent_p.E189E|IKZF2_uc002vek.2_RNA|IKZF2_uc010fuv.2_Intron|IKZF2_uc002vel.2_Silent_p.E163E|IKZF2_uc010fuw.2_Silent_p.E16E|IKZF2_uc010fux.2_Silent_p.E16E|IKZF2_uc010fuy.2_Silent_p.E170E|IKZF2_uc002ven.2_Silent_p.E216E|IKZF2_uc002vei.2_Silent_p.E20E	NM_016260	NP_057344	Q9UKS7	IKZF2_HUMAN	helios isoform 1	242					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)														---	---	---	---
OBSL1	23363	broad.mit.edu	37	2	220424065	220424065	+	Silent	SNP	C	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:220424065C>A	uc010fwk.2	-	9	3165	c.3108G>T	c.(3106-3108)GTG>GTT	p.V1036V	OBSL1_uc002vmh.1_Silent_p.V27V|OBSL1_uc010zli.1_Silent_p.V27V|OBSL1_uc010fwl.1_Silent_p.V511V	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	1036	Ig-like 8.				cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)														---	---	---	---
C3orf20	84077	broad.mit.edu	37	3	14770025	14770025	+	Silent	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:14770025C>T	uc003byy.2	+	12	2174	c.1770C>T	c.(1768-1770)CCC>CCT	p.P590P	C3orf20_uc003byz.2_Silent_p.P468P|C3orf20_uc003bza.2_Silent_p.P468P|C3orf20_uc003bzb.1_Silent_p.P91P	NM_032137	NP_115513	Q8ND61	CC020_HUMAN	hypothetical protein LOC84077	590						cytoplasm|integral to membrane				ovary(3)|skin(1)	4																		---	---	---	---
UBA7	7318	broad.mit.edu	37	3	49850964	49850964	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49850964C>T	uc003cxr.2	-	2	344	c.173G>A	c.(172-174)AGC>AAC	p.S58N		NM_003335	NP_003326	P41226	UBA7_HUMAN	ubiquitin-like modifier activating enzyme 7	58	2 approximate repeats.|1-1.				ISG15-protein conjugation|negative regulation of type I interferon production	cytosol	ATP binding|ISG15 activating enzyme activity|ligase activity			ovary(1)|pancreas(1)	2				BRCA - Breast invasive adenocarcinoma(193;3.58e-06)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)														---	---	---	---
CACNA2D2	9254	broad.mit.edu	37	3	50416351	50416351	+	Missense_Mutation	SNP	T	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:50416351T>A	uc003daq.2	-	13	1372	c.1334A>T	c.(1333-1335)AAC>ATC	p.N445I	CACNA2D2_uc003dap.2_Missense_Mutation_p.N445I	NM_006030	NP_006021	Q9NY47	CA2D2_HUMAN	calcium channel, voltage-dependent, alpha	445	VWFA.|Extracellular (Potential).				energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000365)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)	Gabapentin(DB00996)													---	---	---	---
LRTM1	57408	broad.mit.edu	37	3	54958865	54958865	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:54958865A>C	uc003dhl.2	-	2	519	c.385T>G	c.(385-387)TTG>GTG	p.L129V	CACNA2D3_uc003dhf.2_Intron|CACNA2D3_uc003dhg.1_Intron|CACNA2D3_uc003dhh.1_Intron	NM_020678	NP_065729	Q9HBL6	LRTM1_HUMAN	leucine-rich repeats and transmembrane domains 1	129	LRR 4.|Extracellular (Potential).					integral to membrane					0				KIRC - Kidney renal clear cell carcinoma(284;0.00975)|Kidney(284;0.0112)|OV - Ovarian serous cystadenocarcinoma(275;0.0502)														---	---	---	---
ERC2	26059	broad.mit.edu	37	3	56183149	56183149	+	Silent	SNP	G	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:56183149G>T	uc003dhr.1	-	5	1417	c.1161C>A	c.(1159-1161)ATC>ATA	p.I387I		NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	387	Potential.					cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)														---	---	---	---
HTR1F	3355	broad.mit.edu	37	3	88040704	88040704	+	Silent	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:88040704A>C	uc003dqr.2	+	2	963	c.805A>C	c.(805-807)AGG>CGG	p.R269R		NM_000866	NP_000857	P30939	5HT1F_HUMAN	5-hydroxytryptamine (serotonin) receptor 1F	269	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	serotonin binding|serotonin receptor activity			ovary(3)	3	all_cancers(8;0.147)	Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00664)	Eletriptan(DB00216)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Zolmitriptan(DB00315)													---	---	---	---
ABI3BP	25890	broad.mit.edu	37	3	100595361	100595361	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:100595361T>C	uc003dun.2	-	7	846	c.761A>G	c.(760-762)AAG>AGG	p.K254R	ABI3BP_uc003duo.2_Missense_Mutation_p.K247R|ABI3BP_uc003dup.3_Missense_Mutation_p.K247R	NM_015429	NP_056244	Q7Z7G0	TARSH_HUMAN	ABI gene family, member 3 (NESH) binding protein	254						extracellular space				ovary(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)	4																		---	---	---	---
GK5	256356	broad.mit.edu	37	3	141900416	141900416	+	Intron	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:141900416A>C	uc003euq.1	-						GK5_uc003eup.1_Intron|GK5_uc010hus.1_Intron	NM_001039547	NP_001034636			glycerol kinase 5 (putative)						glycerol metabolic process		ATP binding|glycerol kinase activity				0																		---	---	---	---
XRN1	54464	broad.mit.edu	37	3	142048335	142048335	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:142048335G>A	uc003eus.2	-	37	4409	c.4342C>T	c.(4342-4344)CGA>TGA	p.R1448*	XRN1_uc010huu.2_Nonsense_Mutation_p.R915*|XRN1_uc003eut.2_Nonsense_Mutation_p.R1448*|XRN1_uc003euu.2_Nonsense_Mutation_p.R1449*	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a	1448					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3																		---	---	---	---
PLOD2	5352	broad.mit.edu	37	3	145803056	145803056	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:145803056A>G	uc003evs.1	-	11	1638	c.1132T>C	c.(1132-1134)TTT>CTT	p.F378L	PLOD2_uc003evq.1_Missense_Mutation_p.F38L|PLOD2_uc011bnm.1_Missense_Mutation_p.F323L|PLOD2_uc003evr.1_Missense_Mutation_p.F378L	NM_000935	NP_000926	O00469	PLOD2_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	378					protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2					Vitamin C(DB00126)													---	---	---	---
GPR87	53836	broad.mit.edu	37	3	151012123	151012123	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:151012123G>A	uc003eyt.2	-	3	1272	c.911C>T	c.(910-912)GCG>GTG	p.A304V	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron	NM_023915	NP_076404	Q9BY21	GPR87_HUMAN	G protein-coupled receptor 87	304	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			large_intestine(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)															---	---	---	---
MED12L	116931	broad.mit.edu	37	3	151101934	151101934	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:151101934C>A	uc003eyp.2	+	33	4787	c.4749C>A	c.(4747-4749)GAC>GAA	p.D1583E	MED12L_uc011bnz.1_Missense_Mutation_p.D1443E|P2RY12_uc011boa.1_Intron|P2RY12_uc003eyx.1_Intron|MED12L_uc003eyy.1_Missense_Mutation_p.D746E	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	1583					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)															---	---	---	---
SGEF	26084	broad.mit.edu	37	3	153847381	153847381	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:153847381A>G	uc011bog.1	+	4	1353	c.1142A>G	c.(1141-1143)CAA>CGA	p.Q381R	SGEF_uc011boh.1_Missense_Mutation_p.Q381R	NM_015595	NP_056410	Q96DR7	ARHGQ_HUMAN	Src homology 3 domain-containing guanine	381					regulation of Rho protein signal transduction	intracellular|ruffle	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)															---	---	---	---
PIK3CA	5290	broad.mit.edu	37	3	178928079	178928079	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:178928079G>A	uc003fjk.2	+	8	1514	c.1357G>A	c.(1357-1359)GAA>AAA	p.E453K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	453	C2 PI3K-type.		E -> Q (in cancer; shows an increase in lipid kinase activity; may disrupt the interaction of the C2 PI3K-type domain with the iSH2 region of the p85 regulatory subunit).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E453K(5)|p.E453Q(1)|p.E453A(1)|p.P449_L455del(1)|p.G451_L456>V(1)|p.E453del(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)				57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			---	---	---	---
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	A	A	rs104886003		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			---	---	---	---
CCDC39	339829	broad.mit.edu	37	3	180372680	180372680	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:180372680T>C	uc010hxe.2	-	7	915	c.800A>G	c.(799-801)AAG>AGG	p.K267R	CCDC39_uc003fkn.2_RNA	NM_181426	NP_852091	Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	267	Potential.				axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				ovary(4)	4	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)															---	---	---	---
CCDC39	339829	broad.mit.edu	37	3	180377341	180377341	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:180377341A>C	uc010hxe.2	-	6	752	c.637T>G	c.(637-639)TTT>GTT	p.F213V	CCDC39_uc003fkn.2_RNA	NM_181426	NP_852091	Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	213	Potential.				axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				ovary(4)	4	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)															---	---	---	---
ETV5	2119	broad.mit.edu	37	3	185798929	185798929	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:185798929G>A	uc003fpz.2	-	6	515	c.268C>T	c.(268-270)CGG>TGG	p.R90W	ETV5_uc003fpy.2_Missense_Mutation_p.R132W	NM_004454	NP_004445	P41161	ETV5_HUMAN	ets variant gene 5 (ets-related molecule)	90					cellular response to oxidative stress	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)|skin(2)|breast(1)	5	all_cancers(143;4.06e-12)|Ovarian(172;0.0386)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.62e-24)					T	TMPRSS2|SCL45A3	Prostate 								---	---	---	---
ZDHHC19	131540	broad.mit.edu	37	3	195938172	195938172	+	Silent	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:195938172C>T	uc003fwc.2	-	1	129	c.15G>A	c.(13-15)ACG>ACA	p.T5T	ZDHHC19_uc010hzz.2_RNA|ZDHHC19_uc010iaa.2_RNA|ZDHHC19_uc010iab.2_RNA	NM_001039617	NP_001034706	Q8WVZ1	ZDH19_HUMAN	zinc finger, DHHC domain containing 19	5						integral to membrane	acyltransferase activity|zinc ion binding			ovary(3)	3	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.89e-25)|all cancers(36;1.46e-23)|OV - Ovarian serous cystadenocarcinoma(49;2.1e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0022)														---	---	---	---
EVC2	132884	broad.mit.edu	37	4	5620291	5620291	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:5620291G>A	uc003gij.2	-	15	2674	c.2620C>T	c.(2620-2622)CGA>TGA	p.R874*	EVC2_uc011bwb.1_Nonsense_Mutation_p.R314*|EVC2_uc003gik.2_Nonsense_Mutation_p.R794*	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	874						integral to membrane				large_intestine(3)|ovary(2)	5																		---	---	---	---
DRD5	1816	broad.mit.edu	37	4	9784832	9784832	+	Silent	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:9784832C>T	uc003gmb.3	+	1	1575	c.1179C>T	c.(1177-1179)CTC>CTT	p.L393L		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	393	Cytoplasmic (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)													---	---	---	---
SLIT2	9353	broad.mit.edu	37	4	20270427	20270427	+	Intron	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:20270427C>T	uc003gpr.1	+						SLIT2_uc003gps.1_Intron	NM_004787	NP_004778			slit homolog 2 precursor						apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11																		---	---	---	---
GBA3	57733	broad.mit.edu	37	4	22820403	22820403	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:22820403T>G	uc003gqp.3	+	5	1358	c.1267T>G	c.(1267-1269)TTT>GTT	p.F423V	GBA3_uc010iep.2_Missense_Mutation_p.F116V|GBA3_uc011bxo.1_Missense_Mutation_p.F424V	NM_020973	NP_066024	Q9H227	GBA3_HUMAN	cytosolic beta-glucosidase isoform a	423					glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity				0																		---	---	---	---
PPARGC1A	10891	broad.mit.edu	37	4	23814390	23814390	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:23814390T>C	uc003gqs.2	-	10	2119	c.1999A>G	c.(1999-2001)AGG>GGG	p.R667G	PPARGC1A_uc003gqt.2_RNA	NM_013261	NP_037393	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor	667					androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			ovary(2)|lung(2)|kidney(2)|skin(2)	8		Breast(46;0.0503)																---	---	---	---
PTPN13	5783	broad.mit.edu	37	4	87724935	87724935	+	Silent	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:87724935G>A	uc003hpz.2	+	43	7059	c.6579G>A	c.(6577-6579)ACG>ACA	p.T2193T	PTPN13_uc003hpy.2_Silent_p.T2198T|PTPN13_uc003hqa.2_Silent_p.T2174T|PTPN13_uc003hqb.2_Silent_p.T2002T|PTPN13_uc003hqc.1_Silent_p.T559T	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	2193						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)														---	---	---	---
DDIT4L	115265	broad.mit.edu	37	4	101109157	101109157	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:101109157T>C	uc003hvq.2	-	3	462	c.259A>G	c.(259-261)AGA>GGA	p.R87G		NM_145244	NP_660287	Q96D03	DDT4L_HUMAN	DNA-damage-inducible transcript 4-like	87					negative regulation of signal transduction	cytoplasm				ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;5.75e-09)														---	---	---	---
ANK2	287	broad.mit.edu	37	4	114278657	114278657	+	Silent	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:114278657T>C	uc003ibe.3	+	38	8983	c.8883T>C	c.(8881-8883)TCT>TCC	p.S2961S	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Silent_p.S263S|ANK2_uc011cgb.1_Silent_p.S2976S	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	2928					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)														---	---	---	---
NDST4	64579	broad.mit.edu	37	4	115997948	115997948	+	Missense_Mutation	SNP	A	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:115997948A>T	uc003ibu.2	-	2	924	c.245T>A	c.(244-246)CTC>CAC	p.L82H	NDST4_uc010imw.2_Intron	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	82	Lumenal (Potential).|Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)														---	---	---	---
FAT4	79633	broad.mit.edu	37	4	126371322	126371322	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:126371322T>G	uc003ifj.3	+	9	9151	c.9151T>G	c.(9151-9153)TTG>GTG	p.L3051V	FAT4_uc011cgp.1_Missense_Mutation_p.L1349V|FAT4_uc003ifi.1_Missense_Mutation_p.L529V	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3051	Extracellular (Potential).|Cadherin 29.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18																		---	---	---	---
INTU	27152	broad.mit.edu	37	4	128629739	128629739	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:128629739A>C	uc003ifk.1	+	13	2355	c.2285A>C	c.(2284-2286)AAG>ACG	p.K762T	INTU_uc011cgq.1_RNA	NM_015693	NP_056508	Q9ULD6	PDZD6_HUMAN	PDZ domain containing 6	762										ovary(1)	1																		---	---	---	---
DCLK2	166614	broad.mit.edu	37	4	151023936	151023936	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:151023936A>G	uc003ilm.3	+	2	828	c.728A>G	c.(727-729)AAG>AGG	p.K243R	DCLK2_uc003iln.3_Missense_Mutation_p.K243R|DCLK2_uc003ilo.3_Missense_Mutation_p.K243R|DCLK2_uc003ilp.3_RNA	NM_001040260	NP_001035350	Q8N568	DCLK2_HUMAN	doublecortin-like kinase 2 isoform a	243	Doublecortin 2.				intracellular signal transduction	cytoplasm|cytoskeleton	ATP binding|protein serine/threonine kinase activity			ovary(3)	3	all_hematologic(180;0.151)																	---	---	---	---
RBM46	166863	broad.mit.edu	37	4	155720526	155720526	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:155720526A>C	uc003ioo.2	+	4	1385	c.1212A>C	c.(1210-1212)AAA>AAC	p.K404N	RBM46_uc011cim.1_Missense_Mutation_p.K404N|RBM46_uc003iop.1_Missense_Mutation_p.K404N	NM_144979	NP_659416	Q8TBY0	RBM46_HUMAN	RNA binding motif protein 46	404							nucleotide binding|RNA binding			central_nervous_system(1)|skin(1)	2	all_hematologic(180;0.24)	Renal(120;0.0854)																---	---	---	---
GUCY1A3	2982	broad.mit.edu	37	4	156634503	156634503	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:156634503A>C	uc003iov.2	+	8	1876	c.1340A>C	c.(1339-1341)AAG>ACG	p.K447T	GUCY1A3_uc010iqc.2_Missense_Mutation_p.K447T|GUCY1A3_uc003iow.2_Missense_Mutation_p.K447T|GUCY1A3_uc010iqd.2_Missense_Mutation_p.K446T|GUCY1A3_uc003iox.2_Missense_Mutation_p.K447T|GUCY1A3_uc003ioz.2_Missense_Mutation_p.K212T|GUCY1A3_uc003ioy.2_Missense_Mutation_p.K447T|GUCY1A3_uc010iqe.2_Missense_Mutation_p.K212T|GUCY1A3_uc003ipa.2_Intron|GUCY1A3_uc003ipb.2_Missense_Mutation_p.K447T	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	447					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)														---	---	---	---
TDO2	6999	broad.mit.edu	37	4	156831278	156831278	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:156831278G>T	uc003ipf.1	+	6	597	c.533G>T	c.(532-534)AGA>ATA	p.R178I		NM_005651	NP_005642	P48775	T23O_HUMAN	tryptophan 2,3-dioxygenase	178					tryptophan catabolic process to kynurenine	cytosol	tryptophan 2,3-dioxygenase activity				0	all_hematologic(180;0.24)	Renal(120;0.0854)		KIRC - Kidney renal clear cell carcinoma(143;0.0455)|Kidney(143;0.0568)|COAD - Colon adenocarcinoma(41;0.141)	L-Tryptophan(DB00150)													---	---	---	---
FNIP2	57600	broad.mit.edu	37	4	159790449	159790449	+	Silent	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:159790449T>C	uc003iqe.3	+	13	2844	c.2661T>C	c.(2659-2661)ATT>ATC	p.I887I		NM_020840	NP_065891	Q9P278	FNIP2_HUMAN	folliculin interacting protein 2	887	Interaction with PRKAA1.				DNA damage response, signal transduction resulting in induction of apoptosis|protein phosphorylation|regulation of protein phosphorylation	cytoplasm	protein binding				0	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.00936)														---	---	---	---
CCDC111	201973	broad.mit.edu	37	4	185593358	185593358	+	Silent	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:185593358T>G	uc003iwk.2	+	7	1021	c.588T>G	c.(586-588)GCT>GCG	p.A196A	CCDC111_uc010isd.1_RNA|CCDC111_uc003iwj.2_Silent_p.A196A|CCDC111_uc003iwl.2_Silent_p.A196A|CCDC111_uc003iwm.2_Silent_p.A67A|CCDC111_uc003iwn.2_Silent_p.A21A	NM_152683	NP_689896	Q96LW4	CC111_HUMAN	coiled-coil domain containing 111	196					DNA replication, synthesis of RNA primer		DNA primase activity			central_nervous_system(1)	1		all_lung(41;9.65e-12)|Lung NSC(41;1.64e-11)|Colorectal(36;0.00531)|Hepatocellular(41;0.00932)|Renal(120;0.0246)|Prostate(90;0.0283)|all_hematologic(60;0.0749)|all_neural(102;0.131)		all cancers(43;5.84e-27)|Epithelial(43;2.2e-23)|OV - Ovarian serous cystadenocarcinoma(60;4.28e-11)|STAD - Stomach adenocarcinoma(60;2.66e-05)|GBM - Glioblastoma multiforme(59;3.03e-05)|Colorectal(24;7.57e-05)|BRCA - Breast invasive adenocarcinoma(30;0.000249)|COAD - Colon adenocarcinoma(29;0.000502)|LUSC - Lung squamous cell carcinoma(40;0.00995)|READ - Rectum adenocarcinoma(43;0.173)														---	---	---	---
CCDC110	256309	broad.mit.edu	37	4	186379713	186379713	+	Silent	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:186379713A>G	uc003ixu.3	-	6	2104	c.2028T>C	c.(2026-2028)TTT>TTC	p.F676F	CCDC110_uc003ixv.3_Silent_p.F639F|CCDC110_uc011ckt.1_Silent_p.F676F	NM_152775	NP_689988	Q8TBZ0	CC110_HUMAN	coiled-coil domain containing 110 isoform a	676	Potential.					nucleus				central_nervous_system(1)	1		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;7.86e-05)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|Colorectal(36;0.0381)|all_hematologic(60;0.0749)		OV - Ovarian serous cystadenocarcinoma(60;1.13e-10)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.00014)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00921)|COAD - Colon adenocarcinoma(29;0.0105)|READ - Rectum adenocarcinoma(43;0.164)														---	---	---	---
ZFR	51663	broad.mit.edu	37	5	32400164	32400164	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:32400164A>G	uc003jhr.1	-	9	1741	c.1661T>C	c.(1660-1662)CTT>CCT	p.L554P		NM_016107	NP_057191	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	554					multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding				0				STAD - Stomach adenocarcinoma(35;0.19)														---	---	---	---
SLC45A2	51151	broad.mit.edu	37	5	33982444	33982444	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:33982444A>C	uc003jid.2	-	2	551	c.459T>G	c.(457-459)GAT>GAG	p.D153E	SLC45A2_uc003jie.2_Missense_Mutation_p.D153E|SLC45A2_uc003jif.3_Missense_Mutation_p.D153E|SLC45A2_uc011coe.1_Missense_Mutation_p.D153E	NM_016180	NP_057264	Q9UMX9	S45A2_HUMAN	membrane-associated transporter protein isoform	153	Helical; Name=4; (Potential).				melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3																		---	---	---	---
UGT3A1	133688	broad.mit.edu	37	5	35991320	35991320	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:35991320A>C	uc003jjv.1	-	1	180	c.23T>G	c.(22-24)CTT>CGT	p.L8R	UGT3A1_uc003jjw.1_RNA|UGT3A1_uc011coq.1_Missense_Mutation_p.L8R|UGT3A1_uc011cor.1_Missense_Mutation_p.L8R|UGT3A1_uc003jjy.1_Intron	NM_152404	NP_689617	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	8						integral to membrane	glucuronosyltransferase activity			ovary(2)|central_nervous_system(1)	3	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)															---	---	---	---
GHR	2690	broad.mit.edu	37	5	42718874	42718874	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:42718874A>G	uc003jmt.2	+	10	1308	c.1265A>G	c.(1264-1266)GAT>GGT	p.D422G	GHR_uc011cpq.1_Missense_Mutation_p.D235G	NM_000163	NP_000154	P10912	GHR_HUMAN	growth hormone receptor precursor	422	Cytoplasmic (Potential).				2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			lung(4)|kidney(1)|skin(1)	6		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)													---	---	---	---
DDX4	54514	broad.mit.edu	37	5	55088488	55088488	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:55088488A>C	uc003jqg.3	+	17	1396	c.1322A>C	c.(1321-1323)AAA>ACA	p.K441T	DDX4_uc010ivz.2_Missense_Mutation_p.K421T|DDX4_uc003jqh.3_Missense_Mutation_p.K407T|DDX4_uc003jqj.2_Missense_Mutation_p.K292T	NM_001136034	NP_001129506	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform	441	Helicase ATP-binding.				multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|skin(1)	2		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)																---	---	---	---
GPR98	84059	broad.mit.edu	37	5	89990213	89990213	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:89990213T>G	uc003kju.2	+	33	7736	c.7640T>G	c.(7639-7641)CTC>CGC	p.L2547R	GPR98_uc003kjt.2_Missense_Mutation_p.L253R|GPR98_uc003kjv.2_Missense_Mutation_p.L147R	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	2547	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)														---	---	---	---
PAM	5066	broad.mit.edu	37	5	102295728	102295728	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:102295728A>G	uc003knw.2	+	12	1428	c.1055A>G	c.(1054-1056)AAG>AGG	p.K352R	PAM_uc003kns.2_Missense_Mutation_p.K352R|PAM_uc003knt.2_Missense_Mutation_p.K352R|PAM_uc003knu.2_Missense_Mutation_p.K352R|PAM_uc003knv.2_Missense_Mutation_p.K352R|PAM_uc011cuz.1_Missense_Mutation_p.K255R|PAM_uc003knx.1_Missense_Mutation_p.K44R	NM_000919	NP_000910	P19021	AMD_HUMAN	peptidylglycine alpha-amidating monooxygenase	352	Peptidylglycine alpha-hydroxylating monooxygenase (By similarity).|Intragranular (Potential).				peptide metabolic process|protein modification process	extracellular region|integral to membrane|stored secretory granule	L-ascorbic acid binding|peptidylamidoglycolate lyase activity|peptidylglycine monooxygenase activity|protein binding				0		all_cancers(142;3.12e-07)|all_epithelial(76;3.48e-10)|Prostate(80;0.00914)|Lung NSC(167;0.0213)|Ovarian(225;0.024)|Colorectal(57;0.0251)|all_lung(232;0.0284)		Epithelial(69;1.1e-13)|COAD - Colon adenocarcinoma(37;0.0127)	Vitamin C(DB00126)													---	---	---	---
FBN2	2201	broad.mit.edu	37	5	127855063	127855063	+	Splice_Site	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:127855063T>G	uc003kuu.2	-	5	972	c.533_splice	c.e5-1	p.P178_splice	FBN2_uc003kuv.2_Splice_Site_p.P145_splice|FBN2_uc003kuw.3_Splice_Site_p.P178_splice|FBN2_uc003kux.1_Splice_Site_p.P178_splice	NM_001999	NP_001990			fibrillin 2 precursor						bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)														---	---	---	---
MYOT	9499	broad.mit.edu	37	5	137222974	137222974	+	Missense_Mutation	SNP	T	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:137222974T>A	uc011cye.1	+	10	1414	c.1397T>A	c.(1396-1398)CTT>CAT	p.L466H	PKD2L2_uc010jep.1_5'Flank|PKD2L2_uc003lbw.1_5'Flank|PKD2L2_uc003lbx.2_5'Flank|PKD2L2_uc003lby.2_5'Flank|MYOT_uc003lbv.2_Missense_Mutation_p.L466H|MYOT_uc011cyg.1_Missense_Mutation_p.L282H|MYOT_uc011cyh.1_Missense_Mutation_p.L351H	NM_001135940	NP_001129412	Q9UBF9	MYOTI_HUMAN	myotilin isoform b	466	Necessary for interaction with ACTA1.|Necessary for interaction with FLNC.				muscle contraction	actin cytoskeleton|sarcolemma|sarcomere	actin binding|structural constituent of muscle			large_intestine(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)															---	---	---	---
PCDHA10	56139	broad.mit.edu	37	5	140236926	140236926	+	Silent	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140236926G>A	uc003lhx.2	+	1	1293	c.1293G>A	c.(1291-1293)TCG>TCA	p.S431S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Silent_p.S431S|PCDHA10_uc011dad.1_Silent_p.S431S	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	431	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding	p.S431S(1)		ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHAC2	56134	broad.mit.edu	37	5	140347619	140347619	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140347619T>G	uc003lii.2	+	1	1508	c.1268T>G	c.(1267-1269)GTG>GGG	p.V423G	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lih.2_Intron|PCDHAC2_uc011dag.1_Missense_Mutation_p.V423G	NM_018899	NP_061722	Q9Y5I4	PCDC2_HUMAN	protocadherin alpha subfamily C, 2 isoform 1	423	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
SH3TC2	79628	broad.mit.edu	37	5	148389903	148389903	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:148389903A>G	uc003lpu.2	-	14	3409	c.3257T>C	c.(3256-3258)CTT>CCT	p.L1086P	SH3TC2_uc003lpp.1_RNA|SH3TC2_uc010jgw.2_Missense_Mutation_p.L730P|SH3TC2_uc003lps.2_RNA|SH3TC2_uc003lpt.2_Missense_Mutation_p.L633P|SH3TC2_uc010jgx.2_Missense_Mutation_p.L1079P	NM_024577	NP_078853	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	1086	TPR 5.						binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
FAT2	2196	broad.mit.edu	37	5	150908754	150908754	+	Silent	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:150908754A>G	uc003lue.3	-	14	10024	c.10011T>C	c.(10009-10011)GGT>GGC	p.G3337G	GM2A_uc011dcs.1_Intron|FAT2_uc003lud.3_Silent_p.G30G	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	3337	Cadherin 30.|Extracellular (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)															---	---	---	---
IL12B	3593	broad.mit.edu	37	5	158743698	158743698	+	Missense_Mutation	SNP	T	A	A	rs143277765		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:158743698T>A	uc003lxr.1	-	7	1024	c.982A>T	c.(982-984)AGT>TGT	p.S328C		NM_002187	NP_002178	P29460	IL12B_HUMAN	interleukin 12B precursor	328					cell cycle arrest|cell migration|defense response to Gram-negative bacterium|interferon-gamma biosynthetic process|natural killer cell activation|negative regulation of interleukin-10 production|negative regulation of interleukin-17 production|negative regulation of smooth muscle cell proliferation|positive regulation of activated T cell proliferation|positive regulation of activation of JAK2 kinase activity|positive regulation of cell adhesion|positive regulation of defense response to virus by host|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-17 production|positive regulation of memory T cell differentiation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of natural killer cell proliferation|positive regulation of NF-kappaB import into nucleus|positive regulation of NK T cell activation|positive regulation of NK T cell proliferation|positive regulation of osteoclast differentiation|positive regulation of smooth muscle cell apoptosis|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat4 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|regulation of tyrosine phosphorylation of Stat1 protein|response to UV-B|sexual reproduction|T-helper 1 type immune response|T-helper cell differentiation	interleukin-12 complex|interleukin-23 complex|membrane	cytokine activity|cytokine receptor activity|interleukin-12 receptor binding|protein heterodimerization activity				0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)													OREG0016989	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
WWC1	23286	broad.mit.edu	37	5	167824784	167824784	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:167824784A>C	uc003lzu.2	+	4	582	c.489A>C	c.(487-489)GAA>GAC	p.E163D	WWC1_uc003lzv.2_Missense_Mutation_p.E163D|WWC1_uc011den.1_Missense_Mutation_p.E163D	NM_015238	NP_056053	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1 isoform 3	163	Potential.				cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			ovary(2)|skin(2)|breast(1)	5	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)														---	---	---	---
FOXQ1	94234	broad.mit.edu	37	6	1313596	1313596	+	Silent	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:1313596C>T	uc003mtl.3	+	1	922	c.657C>T	c.(655-657)CGC>CGT	p.R219R		NM_033260	NP_150285	Q9C009	FOXQ1_HUMAN	forkhead box Q1	219					DNA fragmentation involved in apoptotic nuclear change|embryo development|hair follicle morphogenesis|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding				0	Ovarian(93;0.0733)	Breast(5;0.052)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.0954)|BRCA - Breast invasive adenocarcinoma(62;0.18)														---	---	---	---
IP6K3	117283	broad.mit.edu	37	6	33703132	33703132	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:33703132T>C	uc010jvf.2	-	3	658	c.122A>G	c.(121-123)AAG>AGG	p.K41R	IP6K3_uc003ofb.2_Missense_Mutation_p.K41R	NM_001142883	NP_001136355	Q96PC2	IP6K3_HUMAN	inositol hexakisphosphate kinase 3	41					inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|protein phosphorylation	cytoplasm	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol hexakisphosphate 6-kinase activity|inositol trisphosphate 3-kinase activity				0																		---	---	---	---
UBR2	23304	broad.mit.edu	37	6	42612227	42612227	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:42612227A>C	uc011dur.1	+	20	2237	c.2237A>C	c.(2236-2238)AAC>ACC	p.N746T	UBR2_uc011dus.1_Missense_Mutation_p.N391T|UBR2_uc003osh.2_RNA	NM_015255	NP_056070	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin	746					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			ovary(3)|pancreas(1)	4	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)															---	---	---	---
FILIP1	27145	broad.mit.edu	37	6	76072455	76072455	+	Intron	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:76072455T>G	uc003pia.2	-						FILIP1_uc003phy.1_Intron|FILIP1_uc003phz.2_Intron|FILIP1_uc010kbe.2_Intron	NM_015687	NP_056502			filamin A interacting protein 1											skin(3)|ovary(1)	4																		---	---	---	---
DOPEY1	23033	broad.mit.edu	37	6	83845580	83845580	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:83845580A>C	uc003pjs.1	+	20	3373	c.3113A>C	c.(3112-3114)AAT>ACT	p.N1038T	DOPEY1_uc011dyy.1_Missense_Mutation_p.N1029T|DOPEY1_uc010kbl.1_Missense_Mutation_p.N1029T|DOPEY1_uc003pjt.2_5'Flank	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	1038					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)														---	---	---	---
LAMA4	3910	broad.mit.edu	37	6	112471810	112471810	+	Silent	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:112471810A>G	uc003pvu.2	-	17	2385	c.2076T>C	c.(2074-2076)GCT>GCC	p.A692A	LAMA4_uc003pvv.2_Silent_p.A685A|LAMA4_uc003pvt.2_Silent_p.A685A	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	692	Domain II and I.|Potential.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)														---	---	---	---
C6orf170	221322	broad.mit.edu	37	6	121576500	121576500	+	Silent	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:121576500A>G	uc003pyo.1	-	17	2060	c.1992T>C	c.(1990-1992)TCT>TCC	p.S664S	C6orf170_uc003pyq.1_RNA|C6orf170_uc003pyp.1_Silent_p.S183S	NM_152730	NP_689943	Q96NH3	BROMI_HUMAN	hypothetical protein LOC221322	664					multicellular organismal development	cilium|cytoplasm	Rab GTPase activator activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(226;0.00521)														---	---	---	---
SERINC1	57515	broad.mit.edu	37	6	122779730	122779730	+	Silent	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:122779730A>G	uc003pyy.1	-	2	206	c.136T>C	c.(136-138)TTG>CTG	p.L46L		NM_020755	NP_065806	Q9NRX5	SERC1_HUMAN	serine incorporator 1	46	Helical; (Potential).				phosphatidylserine metabolic process|phospholipid biosynthetic process|positive regulation of transferase activity|sphingolipid metabolic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	L-serine transmembrane transporter activity|protein binding			ovary(1)	1				GBM - Glioblastoma multiforme(226;0.126)														---	---	---	---
SHPRH	257218	broad.mit.edu	37	6	146254276	146254276	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:146254276T>G	uc003qlf.2	-	14	3428	c.3029A>C	c.(3028-3030)AAG>ACG	p.K1010T	SHPRH_uc003qld.2_Missense_Mutation_p.K1019T|SHPRH_uc003qle.2_Missense_Mutation_p.K1019T|SHPRH_uc003qlg.1_Missense_Mutation_p.K566T|SHPRH_uc003qlh.2_5'UTR	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	1010					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)														---	---	---	---
VIP	7432	broad.mit.edu	37	6	153075433	153075433	+	Intron	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:153075433T>G	uc003qpe.2	+						VIP_uc003qpf.2_Intron|VIP_uc010kjd.2_Intron	NM_003381	NP_003372			vasoactive intestinal peptide isoform 1						body fluid secretion|G-protein coupled receptor protein signaling pathway|positive regulation of cell proliferation	extracellular region	neuropeptide hormone activity				0		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;4.5e-11)|BRCA - Breast invasive adenocarcinoma(81;0.144)														---	---	---	---
THSD7A	221981	broad.mit.edu	37	7	11581104	11581104	+	Silent	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:11581104G>A	uc003ssf.3	-	6	2016	c.1764C>T	c.(1762-1764)AAC>AAT	p.N588N		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	588	Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)											HNSCC(18;0.044)			---	---	---	---
AGR3	155465	broad.mit.edu	37	7	16900136	16900136	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:16900136C>T	uc003sts.2	-	7	512	c.439G>A	c.(439-441)GAT>AAT	p.D147N		NM_176813	NP_789783	Q8TD06	AGR3_HUMAN	breast cancer membrane protein 11 precursor	147						extracellular region					0	Lung NSC(10;0.0376)|all_lung(11;0.0721)|all_epithelial(12;0.202)			UCEC - Uterine corpus endometrioid carcinoma (126;0.184)														---	---	---	---
KBTBD2	25948	broad.mit.edu	37	7	32909212	32909212	+	Silent	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:32909212T>C	uc003tdb.2	-	4	2276	c.1617A>G	c.(1615-1617)CGA>CGG	p.R539R	AVL9_uc011kai.1_Intron	NM_015483	NP_056298	Q8IY47	KBTB2_HUMAN	kelch repeat and BTB (POZ) domain containing 2	539	Kelch 5.										0			GBM - Glioblastoma multiforme(11;0.0499)															---	---	---	---
FKBP9	11328	broad.mit.edu	37	7	33014900	33014900	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:33014900T>G	uc003tdh.2	+	3	655	c.474T>G	c.(472-474)AGT>AGG	p.S158R	AVL9_uc011kai.1_Intron|FKBP9_uc011kak.1_RNA|FKBP9_uc011kal.1_Missense_Mutation_p.S211R|FKBP9_uc003tdg.2_Missense_Mutation_p.S158R|FKBP9_uc010kwm.2_Missense_Mutation_p.S65R	NM_007270	NP_009201	O95302	FKBP9_HUMAN	FK506 binding protein 9 precursor	158					protein folding	endoplasmic reticulum|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			central_nervous_system(13)|ovary(1)	14			GBM - Glioblastoma multiforme(11;0.0156)															---	---	---	---
ABCB4	5244	broad.mit.edu	37	7	87076341	87076341	+	Intron	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:87076341A>C	uc003uiv.1	-						ABCB4_uc003uiw.1_Intron|ABCB4_uc003uix.1_Intron	NM_018849	NP_061337			ATP-binding cassette, subfamily B, member 4						cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)																	---	---	---	---
COL1A2	1278	broad.mit.edu	37	7	94041406	94041406	+	Silent	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:94041406C>T	uc003ung.1	+	24	1848	c.1377C>T	c.(1375-1377)ATC>ATT	p.I459I	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	459					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)										HNSCC(75;0.22)			---	---	---	---
DLX6	1750	broad.mit.edu	37	7	96639182	96639182	+	Silent	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:96639182C>T	uc003uom.2	+	4	621	c.621C>T	c.(619-621)AGC>AGT	p.S207S	DLX6AS_uc003uol.2_Intron|DLX6AS_uc010lfo.1_Intron	NM_005222	NP_005213	P56179	DLX6_HUMAN	distal-less homeobox 6	117					nervous system development|skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	all_cancers(62;9.56e-09)|all_epithelial(64;7.38e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0855)|Lung NSC(181;0.0858)																	---	---	---	---
ZNF789	285989	broad.mit.edu	37	7	99077375	99077375	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99077375T>C	uc003uqq.1	+	3	335	c.116T>C	c.(115-117)GTG>GCG	p.V39A	ZNF789_uc003uqp.2_Missense_Mutation_p.V39A|ZNF789_uc010lfw.1_5'UTR	NM_213603	NP_998768	Q5FWF6	ZN789_HUMAN	zinc finger protein 789 isoform 1	39	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)																	---	---	---	---
MUC17	140453	broad.mit.edu	37	7	100675453	100675453	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100675453A>C	uc003uxp.1	+	3	809	c.756A>C	c.(754-756)CAA>CAC	p.Q252H	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	252	Extracellular (Potential).|59 X approximate tandem repeats.|2.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)																	---	---	---	---
MUC17	140453	broad.mit.edu	37	7	100686766	100686766	+	Silent	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100686766T>G	uc003uxp.1	+	3	12122	c.12069T>G	c.(12067-12069)ACT>ACG	p.T4023T	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	4023	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)																	---	---	---	---
CTTNBP2	83992	broad.mit.edu	37	7	117432071	117432071	+	Silent	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:117432071A>G	uc003vjf.2	-	4	1271	c.1179T>C	c.(1177-1179)GAT>GAC	p.D393D		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	393	Pro-rich.									ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)														---	---	---	---
TSPAN12	23554	broad.mit.edu	37	7	120446622	120446622	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:120446622A>G	uc003vjk.2	-	7	967	c.593T>C	c.(592-594)CTC>CCC	p.L198P	TSPAN12_uc010lkj.2_Missense_Mutation_p.L71P	NM_012338	NP_036470	O95859	TSN12_HUMAN	transmembrane 4 superfamily member 12	198	Extracellular (Potential).				angiogenesis|cell surface receptor linked signaling pathway|regulation of angiogenesis|retina layer formation	integral to plasma membrane|membrane fraction					0	all_neural(327;0.117)																	---	---	---	---
IQUB	154865	broad.mit.edu	37	7	123119949	123119949	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:123119949A>G	uc003vkn.2	-	8	1887	c.1310T>C	c.(1309-1311)CTT>CCT	p.L437P	IQUB_uc003vko.2_Missense_Mutation_p.L437P|IQUB_uc010lkt.2_Intron|IQUB_uc003vkp.1_Missense_Mutation_p.L437P	NM_178827	NP_849149	Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	437										ovary(3)|large_intestine(1)	4																		---	---	---	---
BLK	640	broad.mit.edu	37	8	11421550	11421550	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:11421550A>G	uc003wty.2	+	13	2032	c.1451A>G	c.(1450-1452)GAG>GGG	p.E484G	BLK_uc003wtz.2_Missense_Mutation_p.E413G|BLK_uc003wua.2_Missense_Mutation_p.E320G	NM_001715	NP_001706	P51451	BLK_HUMAN	B lymphoid tyrosine kinase	484	Protein kinase.				intracellular protein kinase cascade|positive regulation of insulin secretion		ATP binding|non-membrane spanning protein tyrosine kinase activity			large_intestine(1)|stomach(1)|ovary(1)	3			STAD - Stomach adenocarcinoma(15;0.00391)	COAD - Colon adenocarcinoma(149;0.207)														---	---	---	---
DEFB134	613211	broad.mit.edu	37	8	11851601	11851601	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:11851601T>C	uc011kxn.1	-	2	89	c.89A>G	c.(88-90)AAG>AGG	p.K30R		NM_001033019	NP_001028191	Q4QY38	DB134_HUMAN	beta-defensin 134 precursor	30					defense response to bacterium	extracellular region					0			STAD - Stomach adenocarcinoma(15;0.033)	COAD - Colon adenocarcinoma(149;0.159)														---	---	---	---
MTUS1	57509	broad.mit.edu	37	8	17504590	17504590	+	Splice_Site	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:17504590T>G	uc003wxv.2	-	14	3976	c.3502_splice	c.e14-1	p.V1168_splice	MTUS1_uc003wxt.2_Splice_Site_p.V415_splice|MTUS1_uc011kyg.1_Splice_Site_p.V313_splice|MTUS1_uc010lsy.2_Splice_Site|MTUS1_uc003wxw.2_Splice_Site_p.V1114_splice|MTUS1_uc003wxs.2_Splice_Site_p.V334_splice	NM_001001924	NP_001001924			mitochondrial tumor suppressor 1 isoform 1							Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				ovary(1)|skin(1)	2				Colorectal(111;0.0778)														---	---	---	---
DUSP4	1846	broad.mit.edu	37	8	29194829	29194829	+	Missense_Mutation	SNP	C	A	A	rs144675383		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:29194829C>A	uc003xhm.2	-	4	1289	c.899G>T	c.(898-900)CGG>CTG	p.R300L	DUSP4_uc003xhl.2_Missense_Mutation_p.R209L	NM_001394	NP_001385	Q13115	DUS4_HUMAN	dual specificity phosphatase 4 isoform 1	300	Tyrosine-protein phosphatase.				endoderm formation|inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/threonine phosphatase activity			lung(1)	1				KIRC - Kidney renal clear cell carcinoma(542;0.094)|Kidney(114;0.113)														---	---	---	---
MCM4	4173	broad.mit.edu	37	8	48883436	48883436	+	Silent	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:48883436G>A	uc003xqk.1	+	12	1895	c.1800G>A	c.(1798-1800)AAG>AAA	p.K600K	MCM4_uc003xql.1_Silent_p.K600K|MCM4_uc011ldi.1_Silent_p.K587K	NM_182746	NP_877423	P33991	MCM4_HUMAN	minichromosome maintenance complex component 4	600	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(2)|skin(2)	4		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)																---	---	---	---
PREX2	80243	broad.mit.edu	37	8	68942747	68942747	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:68942747A>G	uc003xxv.1	+	6	586	c.559A>G	c.(559-561)ACT>GCT	p.T187A	PREX2_uc003xxu.1_Missense_Mutation_p.T187A|PREX2_uc011lez.1_Missense_Mutation_p.T122A	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	187	DH.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17																		---	---	---	---
ZFHX4	79776	broad.mit.edu	37	8	77764117	77764117	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:77764117A>G	uc003yav.2	+	10	5212	c.4825A>G	c.(4825-4827)AGT>GGT	p.S1609G	ZFHX4_uc003yau.1_Missense_Mutation_p.S1654G|ZFHX4_uc003yaw.1_Missense_Mutation_p.S1609G	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1609						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)												HNSCC(33;0.089)			---	---	---	---
ZFPM2	23414	broad.mit.edu	37	8	106813442	106813442	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:106813442T>G	uc003ymd.2	+	8	1155	c.1132T>G	c.(1132-1134)TTA>GTA	p.L378V	ZFPM2_uc011lhs.1_Missense_Mutation_p.L109V|uc003yme.1_5'Flank	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	378	C2H2-type 3.				blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)															---	---	---	---
C8orf85	441376	broad.mit.edu	37	8	117954916	117954916	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:117954916A>C	uc003yof.2	+	2	463	c.444A>C	c.(442-444)AAA>AAC	p.K148N		NM_001025357	NP_001020528	Q4LEZ3	AARD_HUMAN	alanine and arginine-rich domain-containing	148											0																		---	---	---	---
FER1L6	654463	broad.mit.edu	37	8	125082784	125082784	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:125082784A>G	uc003yqw.2	+	30	4117	c.3911A>G	c.(3910-3912)AAG>AGG	p.K1304R	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1304	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)															---	---	---	---
GSDMC	56169	broad.mit.edu	37	8	130761760	130761760	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:130761760A>C	uc003ysr.2	-	13	2107	c.1225T>G	c.(1225-1227)TTC>GTC	p.F409V		NM_031415	NP_113603	Q9BYG8	GSDMC_HUMAN	melanoma-derived leucine zipper, extra-nuclear	409						mitochondrion				ovary(2)|skin(1)	3																		---	---	---	---
TG	7038	broad.mit.edu	37	8	133899716	133899716	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:133899716A>G	uc003ytw.2	+	9	2140	c.2099A>G	c.(2098-2100)AAC>AGC	p.N700S		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	700	Thyroglobulin type-1 6.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)														---	---	---	---
HSF1	3297	broad.mit.edu	37	8	145535734	145535734	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145535734G>T	uc003zbt.3	+	9	1116	c.946G>T	c.(946-948)GGG>TGG	p.G316W	HSF1_uc003zbu.3_RNA	NM_005526	NP_005517	Q00613	HSF1_HUMAN	heat shock transcription factor 1	316						cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.94e-40)|Epithelial(56;1.12e-39)|all cancers(56;9.11e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0547)|Colorectal(110;0.055)															---	---	---	---
SMARCA2	6595	broad.mit.edu	37	9	2123719	2123719	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:2123719C>T	uc003zhc.2	+	27	3862	c.3763C>T	c.(3763-3765)CGG>TGG	p.R1255W	SMARCA2_uc003zhd.2_Missense_Mutation_p.R1255W|SMARCA2_uc010mha.2_Missense_Mutation_p.R1188W	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	1255					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)														---	---	---	---
ACO1	48	broad.mit.edu	37	9	32434703	32434703	+	Intron	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:32434703A>C	uc003zqw.3	+						ACO1_uc010mjh.1_Intron|ACO1_uc003zqx.3_Intron|ACO1_uc003zqy.3_Intron	NM_002197	NP_002188			aconitase 1						citrate metabolic process|response to iron(II) ion|tricarboxylic acid cycle	cytosol|endoplasmic reticulum|Golgi apparatus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron-responsive element binding|isocitrate hydro-lyase (cis-aconitate-forming) activity|metal ion binding|protein binding				0			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;3.94e-06)														---	---	---	---
RNF38	152006	broad.mit.edu	37	9	36357894	36357894	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:36357894C>T	uc003zzh.2	-	5	807	c.616G>A	c.(616-618)GCA>ACA	p.A206T	RNF38_uc003zzi.2_Missense_Mutation_p.A156T|RNF38_uc003zzj.2_Missense_Mutation_p.A123T|RNF38_uc003zzk.2_Missense_Mutation_p.A123T|RNF38_uc003zzl.2_Missense_Mutation_p.A130T|RNF38_uc003zzm.2_Missense_Mutation_p.A123T	NM_022781	NP_073618	Q9H0F5	RNF38_HUMAN	ring finger protein 38 isoform 1	206			A -> T.				zinc ion binding			central_nervous_system(1)	1			STAD - Stomach adenocarcinoma(86;0.228)															---	---	---	---
TRPM3	80036	broad.mit.edu	37	9	73240173	73240173	+	Silent	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:73240173A>C	uc004aid.2	-	13	1951	c.1707T>G	c.(1705-1707)GCT>GCG	p.A569A	TRPM3_uc004ahu.2_Silent_p.A399A|TRPM3_uc004ahv.2_Silent_p.A381A|TRPM3_uc004ahw.2_Silent_p.A441A|TRPM3_uc004ahx.2_Silent_p.A428A|TRPM3_uc004ahy.2_Silent_p.A441A|TRPM3_uc004ahz.2_Silent_p.A428A|TRPM3_uc004aia.2_Silent_p.A416A|TRPM3_uc004aib.2_Silent_p.A416A|TRPM3_uc004aic.2_Silent_p.A569A	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	594	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9																		---	---	---	---
FOXE1	2304	broad.mit.edu	37	9	100616468	100616468	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:100616468G>A	uc004axu.2	+	1	932	c.272G>A	c.(271-273)CGC>CAC	p.R91H		NM_004473	NP_004464	O00358	FOXE1_HUMAN	forkhead box E1	91	Fork-head.				cell migration|embryonic organ morphogenesis|hair follicle morphogenesis|hard palate development|lens morphogenesis in camera-type eye|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|peripheral nervous system development|pharynx development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|soft palate development|thymus development|thyroid gland development|thyroid hormone generation	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0		Acute lymphoblastic leukemia(62;0.158)																---	---	---	---
LPPR1	54886	broad.mit.edu	37	9	104075105	104075105	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:104075105C>T	uc004bbb.2	+	6	1061	c.662C>T	c.(661-663)ACG>ATG	p.T221M	LPPR1_uc011lvi.1_Missense_Mutation_p.T197M|LPPR1_uc004bbc.2_Missense_Mutation_p.T221M|LPPR1_uc010mtc.2_Missense_Mutation_p.T205M	NM_207299	NP_997182	Q8TBJ4	LPPR1_HUMAN	plasticity related gene 3	221						integral to membrane	catalytic activity				0																		---	---	---	---
ZNF462	58499	broad.mit.edu	37	9	109736459	109736459	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:109736459T>C	uc004bcz.2	+	9	7026	c.6737T>C	c.(6736-6738)GTT>GCT	p.V2246A	ZNF462_uc010mto.2_Missense_Mutation_p.V2155A|ZNF462_uc004bda.2_Missense_Mutation_p.V2154A|ZNF462_uc011lvz.1_Missense_Mutation_p.V203A|ZNF462_uc004bdb.1_Missense_Mutation_p.V154A	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	2246					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5																		---	---	---	---
IKBKAP	8518	broad.mit.edu	37	9	111642333	111642333	+	Silent	SNP	C	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:111642333C>A	uc004bdm.3	-	32	3979	c.3459G>T	c.(3457-3459)CTG>CTT	p.L1153L	IKBKAP_uc004bdl.2_Silent_p.L804L|IKBKAP_uc011lwc.1_Silent_p.L1039L|IKBKAP_uc010mtq.2_Silent_p.L804L|IKBKAP_uc004bdk.2_Silent_p.L157L|IKBKAP_uc010mtp.2_RNA	NM_003640	NP_003631	O95163	ELP1_HUMAN	inhibitor of kappa light polypeptide gene	1153					immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	7																		---	---	---	---
OR2K2	26248	broad.mit.edu	37	9	114090461	114090461	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:114090461A>C	uc011lwp.1	-	1	253	c.253T>G	c.(253-255)TTG>GTG	p.L85V		NM_205859	NP_995581	Q8NGT1	OR2K2_HUMAN	olfactory receptor, family 2, subfamily K,	114	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1																		---	---	---	---
TLR4	7099	broad.mit.edu	37	9	120475898	120475898	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:120475898T>G	uc004bjz.2	+	3	1783	c.1492T>G	c.(1492-1494)TTG>GTG	p.L498V	TLR4_uc004bka.2_Missense_Mutation_p.L458V|TLR4_uc004bkb.2_Missense_Mutation_p.L298V	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	498	LRR 16.|Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16																		---	---	---	---
STRBP	55342	broad.mit.edu	37	9	125936031	125936031	+	Silent	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:125936031C>T	uc004bns.2	-	5	745	c.315G>A	c.(313-315)CTG>CTA	p.L105L	STRBP_uc004bnt.2_5'UTR|STRBP_uc004bnu.2_Silent_p.L91L|STRBP_uc004bnv.2_Silent_p.L105L	NM_018387	NP_060857	Q96SI9	STRBP_HUMAN	spermatid perinuclear RNA binding protein	105	DZF.				multicellular organismal development	cytoplasm|nucleus	DNA binding			breast(1)|skin(1)	2																		---	---	---	---
NEBL	10529	broad.mit.edu	37	10	21139351	21139351	+	Silent	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:21139351T>G	uc001iqi.2	-	11	1486	c.1089A>C	c.(1087-1089)TCA>TCC	p.S363S	NEBL_uc001iqj.2_RNA|NEBL_uc001iqk.2_Intron	NM_006393	NP_006384	O76041	NEBL_HUMAN	nebulette sarcomeric isoform	363	Nebulin 10.				regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2																		---	---	---	---
PGBD3	267004	broad.mit.edu	37	10	50724274	50724274	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:50724274T>G	uc001jht.2	-	2	1142	c.887A>C	c.(886-888)AAG>ACG	p.K296T	ERCC6_uc001jhs.3_Intron|PGBD3_uc009xoe.2_Missense_Mutation_p.K764T|PGBD3_uc001jhu.2_Missense_Mutation_p.K764T	NM_170753	NP_736609	Q8N328	PGBD3_HUMAN	hypothetical protein LOC267004	296										pancreas(1)|breast(1)|skin(1)	3																		---	---	---	---
PCDH15	65217	broad.mit.edu	37	10	55700715	55700715	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:55700715A>G	uc001jju.1	-	24	3538	c.3143T>C	c.(3142-3144)CTT>CCT	p.L1048P	PCDH15_uc010qhq.1_Missense_Mutation_p.L1053P|PCDH15_uc010qhr.1_Missense_Mutation_p.L1048P|PCDH15_uc010qhs.1_Missense_Mutation_p.L1060P|PCDH15_uc010qht.1_Missense_Mutation_p.L1055P|PCDH15_uc010qhu.1_Missense_Mutation_p.L1048P|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.L1048P|PCDH15_uc010qhw.1_Missense_Mutation_p.L1011P|PCDH15_uc010qhx.1_Missense_Mutation_p.L977P|PCDH15_uc010qhy.1_Missense_Mutation_p.L1053P|PCDH15_uc010qhz.1_Missense_Mutation_p.L1048P|PCDH15_uc010qia.1_Missense_Mutation_p.L1026P|PCDH15_uc010qib.1_Missense_Mutation_p.L1026P	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1048	Cadherin 10.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)													HNSCC(58;0.16)			---	---	---	---
ARHGAP19	84986	broad.mit.edu	37	10	99019212	99019212	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:99019212A>C	uc001knb.2	-	5	816	c.787T>G	c.(787-789)TCA>GCA	p.S263A	ARHGAP19_uc001kmy.2_RNA|ARHGAP19_uc001kna.2_Missense_Mutation_p.S254A|ARHGAP19_uc009xvi.2_RNA|ARHGAP19_uc009xvj.2_Missense_Mutation_p.S263A|ARHGAP19_uc009xvk.2_Missense_Mutation_p.S57A	NM_032900	NP_116289	Q14CB8	RHG19_HUMAN	Rho GTPase activating protein 19	263	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	GTPase activator activity				0		Colorectal(252;0.0854)		Epithelial(162;7.65e-09)|all cancers(201;4.49e-07)														---	---	---	---
CPN1	1369	broad.mit.edu	37	10	101802248	101802248	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:101802248T>G	uc001kql.2	-	9	1573	c.1313A>C	c.(1312-1314)AAA>ACA	p.K438T		NM_001308	NP_001299	P15169	CBPN_HUMAN	carboxypeptidase N, polypeptide 1 precursor	438					proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(3)|pancreas(1)	4		Colorectal(252;0.234)		Epithelial(162;4.77e-10)|all cancers(201;3.82e-08)														---	---	---	---
NOLC1	9221	broad.mit.edu	37	10	103919991	103919991	+	Missense_Mutation	SNP	T	G	G	rs151088360	byFrequency	TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:103919991T>G	uc001kuo.2	+	9	1225	c.990T>G	c.(988-990)GAT>GAG	p.D330E	NOLC1_uc001kup.2_Missense_Mutation_p.D340E|NOLC1_uc001kuq.2_Missense_Mutation_p.D331E|NOLC1_uc009xxb.1_Missense_Mutation_p.D49E|NOLC1_uc001kur.2_Missense_Mutation_p.D49E	NM_004741	NP_004732	Q14978	NOLC1_HUMAN	nucleolar and coiled-body phosphoprotein 1	330	11 X 12 AA approximate repeats of an acidic serine cluster.|Interacts with RPA194.|Acidic serine cluster 6.				mitosis|rRNA processing	cytoplasm|nucleolus	ATP binding|GTP binding|protein binding			ovary(1)	1		Colorectal(252;0.122)		Epithelial(162;5.19e-08)|all cancers(201;9.43e-07)														---	---	---	---
TRIM8	81603	broad.mit.edu	37	10	104416988	104416988	+	Silent	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:104416988C>T	uc001kvz.2	+	6	1656	c.1533C>T	c.(1531-1533)TCC>TCT	p.S511S		NM_030912	NP_112174	Q9BZR9	TRIM8_HUMAN	tripartite motif-containing 8	511						cytoplasm|PML body	ligase activity|protein homodimerization activity|zinc ion binding			ovary(1)	1		Colorectal(252;0.122)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)														---	---	---	---
PNLIPRP3	119548	broad.mit.edu	37	10	118236234	118236234	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:118236234A>C	uc001lcl.3	+	11	1344	c.1243A>C	c.(1243-1245)AGT>CGT	p.S415R		NM_001011709	NP_001011709	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3 precursor	415	PLAT.				lipid catabolic process	extracellular region	triglyceride lipase activity	p.S415C(1)		ovary(1)	1				all cancers(201;0.0131)														---	---	---	---
SLC18A2	6571	broad.mit.edu	37	10	119003515	119003515	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:119003515A>C	uc001ldd.1	+	3	186	c.155A>C	c.(154-156)AAG>ACG	p.K52T	SLC18A2_uc009xyy.1_5'UTR	NM_003054	NP_003045	Q05940	VMAT2_HUMAN	solute carrier family 18 (vesicular monoamine),	52	Lumenal, vesicle (Potential).				neurotransmitter secretion	clathrin sculpted monoamine transport vesicle membrane|integral to plasma membrane|membrane fraction	monoamine transmembrane transporter activity				0		Colorectal(252;0.19)		all cancers(201;0.029)	Alseroxylon(DB00386)|Reserpine(DB00206)|Tetrabenazine(DB04844)													---	---	---	---
TACC2	10579	broad.mit.edu	37	10	123843481	123843481	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:123843481T>C	uc001lfv.2	+	4	1826	c.1466T>C	c.(1465-1467)GTT>GCT	p.V489A	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Missense_Mutation_p.V489A|TACC2_uc010qtv.1_Missense_Mutation_p.V489A	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	489	Pro-rich.					microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)																---	---	---	---
OR51G1	79324	broad.mit.edu	37	11	4945175	4945175	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:4945175A>C	uc010qyr.1	-	1	395	c.395T>G	c.(394-396)CTG>CGG	p.L132R		NM_001005237	NP_001005237	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G,	132	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)														---	---	---	---
OR56A3	390083	broad.mit.edu	37	11	5969389	5969389	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:5969389A>C	uc010qzt.1	+	1	813	c.813A>C	c.(811-813)AAA>AAC	p.K271N		NM_001003443	NP_001003443	Q8NH54	O56A3_HUMAN	olfactory receptor, family 56, subfamily A,	271	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;9.41e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)														---	---	---	---
USH1C	10083	broad.mit.edu	37	11	17532052	17532052	+	Intron	SNP	C	A	A	rs146333270		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:17532052C>A	uc001mnf.2	-						USH1C_uc001mne.2_Missense_Mutation_p.R477L|USH1C_uc009yhb.2_Intron|USH1C_uc001mng.2_Intron|USH1C_uc001mnd.2_Intron	NM_005709	NP_005700			harmonin isoform a						equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			ovary(1)	1																		---	---	---	---
LRP4	4038	broad.mit.edu	37	11	46896598	46896598	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:46896598G>A	uc001ndn.3	-	28	4128	c.3982C>T	c.(3982-3984)CCT>TCT	p.P1328S		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	1328	Extracellular (Potential).				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)														---	---	---	---
OR4C6	219432	broad.mit.edu	37	11	55433389	55433389	+	Missense_Mutation	SNP	T	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55433389T>A	uc001nht.3	+	3	1012	c.747T>A	c.(745-747)TTT>TTA	p.F249L	OR4C6_uc010rik.1_Missense_Mutation_p.F249L	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	249	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2																		---	---	---	---
OR4C6	219432	broad.mit.edu	37	11	55433390	55433390	+	Missense_Mutation	SNP	G	T	T	rs75211559		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55433390G>T	uc001nht.3	+	3	1013	c.748G>T	c.(748-750)GTC>TTC	p.V250F	OR4C6_uc010rik.1_Missense_Mutation_p.V250F	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	250	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2																		---	---	---	---
OR5D14	219436	broad.mit.edu	37	11	55563569	55563569	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55563569T>C	uc010rim.1	+	1	538	c.538T>C	c.(538-540)TTT>CTT	p.F180L		NM_001004735	NP_001004735	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D,	180	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3		all_epithelial(135;0.196)																---	---	---	---
MS4A6A	64231	broad.mit.edu	37	11	59949151	59949151	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:59949151T>G	uc001nor.2	-	2	288	c.50A>C	c.(49-51)AAT>ACT	p.N17T	MS4A6A_uc001noq.2_Missense_Mutation_p.N17T|MS4A6A_uc001nos.3_Missense_Mutation_p.N45T|MS4A6A_uc009ymv.2_Missense_Mutation_p.N17T|MS4A6A_uc001not.2_Missense_Mutation_p.N17T|MS4A6A_uc010rla.1_Missense_Mutation_p.N45T|MS4A6A_uc010rlb.1_Missense_Mutation_p.N17T	NM_152852	NP_690591	Q9H2W1	M4A6A_HUMAN	membrane-spanning 4-domains, subfamily A, member	17	Cytoplasmic (Potential).					integral to membrane	receptor activity				0																		---	---	---	---
MS4A10	341116	broad.mit.edu	37	11	60561521	60561521	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:60561521T>C	uc001npz.1	+	5	533	c.437T>C	c.(436-438)CTC>CCC	p.L146P		NM_206893	NP_996776	Q96PG2	M4A10_HUMAN	membrane-spanning 4-domains, subfamily A, member	146	Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|skin(1)	2																		---	---	---	---
NUMA1	4926	broad.mit.edu	37	11	71724063	71724063	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:71724063G>A	uc001orl.1	-	15	4658	c.4486C>T	c.(4486-4488)CGA>TGA	p.R1496*	NUMA1_uc009ysw.1_Nonsense_Mutation_p.R1059*|NUMA1_uc001ork.1_Intron|NUMA1_uc001orm.1_Nonsense_Mutation_p.R1496*|NUMA1_uc001orn.2_Nonsense_Mutation_p.R1059*|NUMA1_uc009ysx.1_Nonsense_Mutation_p.R1496*|NUMA1_uc001oro.1_Nonsense_Mutation_p.R1496*	NM_006185	NP_006176	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	1496	Potential.				G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			ovary(3)|lung(2)|skin(2)|central_nervous_system(1)	8								T	RARA	APL								---	---	---	---
GPR83	10888	broad.mit.edu	37	11	94113847	94113847	+	Missense_Mutation	SNP	A	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:94113847A>T	uc001pet.2	-	4	912	c.740T>A	c.(739-741)CTC>CAC	p.L247H		NM_016540	NP_057624	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83 precursor	247	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			central_nervous_system(2)|ovary(1)	3		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)																---	---	---	---
USP28	57646	broad.mit.edu	37	11	113674571	113674571	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:113674571C>T	uc001poh.2	-	22	2720	c.2687G>A	c.(2686-2688)CGA>CAA	p.R896Q	USP28_uc001pog.2_Missense_Mutation_p.R572Q|USP28_uc010rwy.1_Missense_Mutation_p.R739Q|USP28_uc001poi.2_Missense_Mutation_p.R219Q	NM_020886	NP_065937	Q96RU2	UBP28_HUMAN	ubiquitin specific protease 28	896					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|breast(2)|ovary(1)|large_intestine(1)|kidney(1)	7		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)														---	---	---	---
A2ML1	144568	broad.mit.edu	37	12	8998053	8998053	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:8998053A>C	uc001quz.3	+	13	1590	c.1492A>C	c.(1492-1494)AGT>CGT	p.S498R	A2ML1_uc001qva.1_Missense_Mutation_p.S78R|A2ML1_uc010sgm.1_5'UTR	NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	342						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3																		---	---	---	---
LRRK2	120892	broad.mit.edu	37	12	40716140	40716140	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:40716140A>C	uc001rmg.3	+	37	5458	c.5337A>C	c.(5335-5337)CAA>CAC	p.Q1779H	LRRK2_uc009zjw.2_Missense_Mutation_p.Q617H|LRRK2_uc001rmi.2_Missense_Mutation_p.Q612H	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1779					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)																---	---	---	---
TMEM117	84216	broad.mit.edu	37	12	44782372	44782372	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:44782372T>G	uc001rod.2	+	8	1528	c.1462T>G	c.(1462-1464)TTG>GTG	p.L488V	TMEM117_uc001roe.2_Missense_Mutation_p.L384V|TMEM117_uc009zkc.2_3'UTR	NM_032256	NP_115632	Q9H0C3	TM117_HUMAN	transmembrane protein 117	488						endoplasmic reticulum|integral to membrane					0	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.124)														---	---	---	---
ERBB3	2065	broad.mit.edu	37	12	56478854	56478854	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56478854G>T	uc001sjh.2	+	3	503	c.310G>T	c.(310-312)GTG>TTG	p.V104L	ERBB3_uc009zoj.2_RNA|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Missense_Mutation_p.V45L|ERBB3_uc001sjg.2_Missense_Mutation_p.V104L	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	104	Extracellular (Potential).		V -> M (in an ovarian mucinous carcinoma sample; somatic mutation).		cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity	p.V104M(1)		lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)															---	---	---	---
ESYT1	23344	broad.mit.edu	37	12	56525562	56525562	+	Silent	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56525562C>T	uc001sjq.2	+	7	884	c.834C>T	c.(832-834)ACC>ACT	p.T278T	ESYT1_uc001sjr.2_Silent_p.T278T	NM_015292	NP_056107	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	278						integral to membrane				ovary(4)|skin(1)	5																		---	---	---	---
MYF6	4618	broad.mit.edu	37	12	81101582	81101582	+	Silent	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:81101582A>G	uc001szf.1	+	1	137	c.84A>G	c.(82-84)GCA>GCG	p.A28A		NM_002469	NP_002460	P23409	MYF6_HUMAN	myogenic factor 6	28					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1																		---	---	---	---
NR1H4	9971	broad.mit.edu	37	12	100904824	100904824	+	Silent	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:100904824G>A	uc001tht.1	+	2	406	c.378G>A	c.(376-378)GCG>GCA	p.A126A	NR1H4_uc001thp.1_Silent_p.A116A|NR1H4_uc001thq.1_Silent_p.A116A|NR1H4_uc010svj.1_RNA|NR1H4_uc001thr.1_Silent_p.A116A|NR1H4_uc010svk.1_Silent_p.A116A|NR1H4_uc001ths.1_Silent_p.A126A	NM_005123	NP_005114	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	126					bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding	p.A116A(1)		ovary(1)|lung(1)|skin(1)	3																		---	---	---	---
STAB2	55576	broad.mit.edu	37	12	104144357	104144357	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:104144357G>A	uc001tjw.2	+	60	6625	c.6439G>A	c.(6439-6441)GGC>AGC	p.G2147S	STAB2_uc009zug.2_RNA	NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	2147	Extracellular (Potential).|EGF-like 17.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14																		---	---	---	---
DAO	1610	broad.mit.edu	37	12	109294207	109294207	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:109294207T>C	uc001tnr.3	+	11	1093	c.940T>C	c.(940-942)TAC>CAC	p.Y314H	DAO_uc001tnq.3_Missense_Mutation_p.Y248H|DAO_uc009zvb.2_RNA|DAO_uc001tns.3_RNA	NM_001917	NP_001908	P14920	OXDA_HUMAN	D-amino-acid oxidase	314	FAD.				glyoxylate metabolic process	peroxisomal matrix	binding|D-amino-acid oxidase activity			ovary(1)|skin(1)	2																		---	---	---	---
ACACB	32	broad.mit.edu	37	12	109612047	109612047	+	Intron	SNP	C	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:109612047C>A	uc001tob.2	+						ACACB_uc001toc.2_Intron	NM_001093	NP_001084			acetyl-Coenzyme A carboxylase beta						acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)													---	---	---	---
UBE3B	89910	broad.mit.edu	37	12	109959319	109959319	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:109959319A>G	uc001top.2	+	21	2930	c.2327A>G	c.(2326-2328)GAG>GGG	p.E776G	UBE3B_uc001toq.2_Missense_Mutation_p.E776G|UBE3B_uc001tos.2_Missense_Mutation_p.E203G|UBE3B_uc001too.1_RNA|UBE3B_uc009zvj.1_Missense_Mutation_p.E776G	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	776	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4																		---	---	---	---
TMEM132D	121256	broad.mit.edu	37	12	129566470	129566470	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:129566470T>G	uc009zyl.1	-	7	2085	c.1757A>C	c.(1756-1758)GAG>GCG	p.E586A	TMEM132D_uc001uia.2_Missense_Mutation_p.E124A	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	586	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)														---	---	---	---
PARP4	143	broad.mit.edu	37	13	25049733	25049733	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:25049733A>C	uc001upl.2	-	15	1897	c.1791T>G	c.(1789-1791)GAT>GAG	p.D597E	PARP4_uc010tdc.1_Missense_Mutation_p.D597E	NM_006437	NP_006428	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	597					cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity	p.D597H(1)		ovary(3)|skin(1)	4		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)														---	---	---	---
NALCN	259232	broad.mit.edu	37	13	101944618	101944618	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:101944618A>G	uc001vox.1	-	8	1088	c.899T>C	c.(898-900)TTC>TCC	p.F300S	NALCN_uc001voy.2_Missense_Mutation_p.F15S|NALCN_uc001voz.2_Missense_Mutation_p.F300S|NALCN_uc001vpa.2_Missense_Mutation_p.F300S	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	300	Extracellular (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)																	---	---	---	---
Unknown	0	broad.mit.edu	37	14	22783282	22783282	+	Intron	SNP	A	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:22783282A>T	uc001wbw.2	+						uc010aja.1_Intron|uc010tmk.1_Intron|uc010tmo.1_Intron|uc001wco.2_Intron|uc010aje.1_Intron|uc001wcp.2_Intron|uc001wcr.1_Intron|uc001wcs.1_Intron|uc010ajf.1_Intron|uc010ajg.1_Intron|uc001wcx.3_Intron|uc001wdd.2_Intron|uc010ajj.1_Intron|uc001wde.1_Intron|uc001wdf.2_Intron|uc010ajk.1_Intron|uc001wdg.1_Intron|uc010ajl.1_Intron|uc001wdj.2_Intron|uc010ajo.1_Intron|uc010ajp.1_Intron|uc001wdq.2_Missense_Mutation_p.K93I					SubName: Full=Alpha-chain C region; Flags: Fragment;																														---	---	---	---
LTB4R	1241	broad.mit.edu	37	14	24785153	24785153	+	Missense_Mutation	SNP	T	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:24785153T>A	uc001wos.2	+	2	617	c.296T>A	c.(295-297)GTC>GAC	p.V99D	LTB4R_uc010alp.2_Missense_Mutation_p.V99D|LTB4R_uc001wou.2_Missense_Mutation_p.V99D	NM_001143919	NP_001137391	Q15722	LT4R1_HUMAN	leukotriene B4 receptor	99	Helical; Name=3; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular component movement|immune response|inflammatory response|muscle contraction	integral to plasma membrane	nucleotide binding				0				GBM - Glioblastoma multiforme(265;0.018)														---	---	---	---
RALGAPA1	253959	broad.mit.edu	37	14	36096777	36096777	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:36096777T>C	uc001wti.2	-	33	5249	c.4858A>G	c.(4858-4860)AGT>GGT	p.S1620G	RALGAPA1_uc010amp.2_RNA|RALGAPA1_uc001wtj.2_Missense_Mutation_p.S1620G|RALGAPA1_uc010tpv.1_Missense_Mutation_p.S1633G|RALGAPA1_uc010tpw.1_Missense_Mutation_p.S1667G	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	1620	Minimal domain that binds to TCF3/E12 (By similarity).				activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4																		---	---	---	---
FSCB	84075	broad.mit.edu	37	14	44975246	44975246	+	Silent	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:44975246T>C	uc001wvn.2	-	1	1254	c.945A>G	c.(943-945)AAA>AAG	p.K315K		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	315						cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)														---	---	---	---
MAX	4149	broad.mit.edu	37	14	65544747	65544747	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:65544747C>T	uc001xif.1	-	4	349	c.179G>A	c.(178-180)CGG>CAG	p.R60Q	MAX_uc001xic.1_Intron|MAX_uc001xie.1_Missense_Mutation_p.R60Q|MAX_uc010aql.1_Intron|MAX_uc001xig.1_Missense_Mutation_p.R51Q|MAX_uc001xih.1_RNA|MAX_uc001xii.1_Missense_Mutation_p.R51Q|MAX_uc001xij.1_Missense_Mutation_p.R60Q	NM_002382	NP_002373	P61244	MAX_HUMAN	MAX protein isoform a	60	Helix-loop-helix motif.				transcription from RNA polymerase II promoter	cytoplasm|MLL1 complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			lung(1)	1				all cancers(60;0.000776)|OV - Ovarian serous cystadenocarcinoma(108;0.00359)|BRCA - Breast invasive adenocarcinoma(234;0.00999)														---	---	---	---
KIAA1409	57578	broad.mit.edu	37	14	94007143	94007143	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:94007143A>G	uc001ybv.1	+	10	1042	c.959A>G	c.(958-960)CAG>CGG	p.Q320R	KIAA1409_uc001ybs.1_Missense_Mutation_p.Q320R|KIAA1409_uc001ybu.1_Missense_Mutation_p.Q258R	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	497						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)														---	---	---	---
C14orf49	161176	broad.mit.edu	37	14	95912417	95912417	+	Missense_Mutation	SNP	C	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:95912417C>G	uc001yei.3	-	8	1476	c.1461G>C	c.(1459-1461)ATG>ATC	p.M487I	C14orf49_uc010avi.2_Missense_Mutation_p.M487I|C14orf49_uc001yej.1_Missense_Mutation_p.M487I	NM_152592	NP_689805	Q6ZMZ3	SYNE3_HUMAN	nesprin-3	487	Cytoplasmic (Potential).				cytoskeletal anchoring at nuclear membrane	integral to membrane|nuclear outer membrane|SUN-KASH complex	actin binding			central_nervous_system(1)	1		all_cancers(154;0.0937)		COAD - Colon adenocarcinoma(157;0.245)														---	---	---	---
OR4N4	283694	broad.mit.edu	37	15	22382731	22382731	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:22382731T>G	uc001yuc.1	+	7	1240	c.259T>G	c.(259-261)TCT>GCT	p.S87A	LOC727924_uc001yub.1_RNA|OR4N4_uc010tzv.1_Missense_Mutation_p.S87A	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,	87	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)														---	---	---	---
PAR4	347745	broad.mit.edu	37	15	25456941	25456941	+	Intron	SNP	T	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:25456941T>A	uc001yzk.1	+						PAR4_uc010ayo.1_Intron|SNORD115-20_uc001yzq.1_Intron|PAR4_uc001yzs.2_RNA|uc001yzt.1_5'Flank|HBII-52-24_uc010ayp.1_5'Flank					Homo sapiens clone Rt-13I SNURF-SNRPN mRNA, downstream untranslated exons, alternatively spliced.												0																		---	---	---	---
SLC12A6	9990	broad.mit.edu	37	15	34533513	34533513	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:34533513T>C	uc001zhw.2	-	17	2352	c.2188A>G	c.(2188-2190)ATC>GTC	p.I730V	SLC12A6_uc001zhv.2_Missense_Mutation_p.I679V|SLC12A6_uc001zhx.2_Missense_Mutation_p.I715V|SLC12A6_uc001zhy.2_RNA|SLC12A6_uc001zhz.2_RNA|SLC12A6_uc001zia.2_Missense_Mutation_p.I671V|SLC12A6_uc001zib.2_Missense_Mutation_p.I721V|SLC12A6_uc001zic.2_Missense_Mutation_p.I730V|SLC12A6_uc010bau.2_Missense_Mutation_p.I730V|SLC12A6_uc001zid.2_Missense_Mutation_p.I671V|SLC12A6_uc001zht.2_RNA|SLC12A6_uc001zhu.2_Missense_Mutation_p.I542V	NM_133647	NP_598408	Q9UHW9	S12A6_HUMAN	solute carrier family 12, member 6 isoform a	730					angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|ovary(1)|skin(1)	7		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)													---	---	---	---
GPR176	11245	broad.mit.edu	37	15	40094058	40094058	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:40094058A>G	uc001zkj.1	-	3	1689	c.823T>C	c.(823-825)TTC>CTC	p.F275L	GPR176_uc010uck.1_Missense_Mutation_p.F215L	NM_007223	NP_009154	Q14439	GP176_HUMAN	G protein-coupled receptor 176	275	Helical; Name=6; (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity			ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		all_cancers(109;4.05e-15)|all_epithelial(112;2.96e-13)|Lung NSC(122;8.53e-11)|all_lung(180;2.71e-09)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;4.4e-06)|BRCA - Breast invasive adenocarcinoma(123;0.123)												OREG0023053	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
NDUFAF1	51103	broad.mit.edu	37	15	41679693	41679693	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:41679693T>G	uc001znx.2	-	5	1315	c.933A>C	c.(931-933)GAA>GAC	p.E311D	NDUFAF1_uc010bcf.2_RNA	NM_016013	NP_057097	Q9Y375	CIA30_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	311					mitochondrial electron transport, NADH to ubiquinone|protein complex assembly	mitochondrial respiratory chain complex I	unfolded protein binding			ovary(1)	1		all_cancers(109;5.07e-19)|all_epithelial(112;2.43e-16)|Lung NSC(122;1.81e-11)|all_lung(180;4.81e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;8e-17)|GBM - Glioblastoma multiforme(113;1.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.114)														---	---	---	---
MGA	23269	broad.mit.edu	37	15	42040962	42040962	+	Silent	SNP	A	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:42040962A>T	uc010ucy.1	+	16	5521	c.5340A>T	c.(5338-5340)ACA>ACT	p.T1780T	MGA_uc010ucz.1_Silent_p.T1571T|MGA_uc010uda.1_Silent_p.T396T|MGA_uc001zoi.2_5'UTR	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)														---	---	---	---
C15orf39	56905	broad.mit.edu	37	15	75500605	75500605	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:75500605G>T	uc002azp.3	+	2	2536	c.2216G>T	c.(2215-2217)CGG>CTG	p.R739L	C15orf39_uc002azq.3_Missense_Mutation_p.R739L|C15orf39_uc002azr.3_Missense_Mutation_p.R137L	NM_015492	NP_056307	Q6ZRI6	CO039_HUMAN	hypothetical protein LOC56905	739											0																		---	---	---	---
DNAJA4	55466	broad.mit.edu	37	15	78566640	78566640	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:78566640A>G	uc002bdj.1	+	4	637	c.520A>G	c.(520-522)ATC>GTC	p.I174V	DNAJA4_uc002bdi.2_Missense_Mutation_p.I203V|DNAJA4_uc002bdk.2_Missense_Mutation_p.I147V|DNAJA4_uc002bdl.2_Missense_Mutation_p.I89V|DNAJA4_uc002bdm.1_5'Flank	NM_001130182	NP_001123654	Q8WW22	DNJA4_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 4	174	CR-type.				protein folding|response to heat	membrane	ATP binding|heat shock protein binding|metal ion binding|unfolded protein binding			skin(1)	1																		---	---	---	---
OR4F6	390648	broad.mit.edu	37	15	102346405	102346405	+	Silent	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:102346405T>C	uc010utr.1	+	1	483	c.483T>C	c.(481-483)GCT>GCC	p.A161A		NM_001005326	NP_001005326	Q8NGB9	OR4F6_HUMAN	olfactory receptor, family 4, subfamily F,	161	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)															---	---	---	---
NETO2	81831	broad.mit.edu	37	16	47117496	47117496	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:47117496T>C	uc002eer.1	-	9	1599	c.1214A>G	c.(1213-1215)GAC>GGC	p.D405G	NETO2_uc002eeq.1_Missense_Mutation_p.D140G|NETO2_uc010vgf.1_Missense_Mutation_p.D262G	NM_018092	NP_060562	Q8NC67	NETO2_HUMAN	neuropilin- and tolloid-like protein 2	405	Cytoplasmic (Potential).					integral to membrane	receptor activity				0		all_cancers(37;0.00114)|all_lung(18;0.00432)|Lung NSC(13;0.0384)|Breast(268;0.174)													HNSCC(25;0.065)			---	---	---	---
LPCAT2	54947	broad.mit.edu	37	16	55613109	55613109	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:55613109T>G	uc002eie.3	+	13	1584	c.1403T>G	c.(1402-1404)GTT>GGT	p.V468G	LPCAT2_uc002eic.2_Missense_Mutation_p.V198G	NM_017839	NP_060309	Q7L5N7	PCAT2_HUMAN	lysophosphatidylcholine acyltransferase 2	468	Lumenal (Potential).				cellular membrane organization|platelet activating factor biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|Golgi stack|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding				0																		---	---	---	---
GPR114	221188	broad.mit.edu	37	16	57597818	57597818	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:57597818G>A	uc002elx.3	+	5	441	c.356G>A	c.(355-357)CGG>CAG	p.R119Q	GPR114_uc010vhr.1_Missense_Mutation_p.R119Q|GPR114_uc002ely.2_Missense_Mutation_p.R119Q	NM_153837	NP_722579	Q8IZF4	GP114_HUMAN	G protein-coupled receptor 114 precursor	119	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)	1																		---	---	---	---
TK2	7084	broad.mit.edu	37	16	66565325	66565325	+	Silent	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:66565325A>C	uc002eos.2	-	5	684	c.459T>G	c.(457-459)ACT>ACG	p.T153T	TK2_uc010vip.1_Silent_p.T14T|TK2_uc002eor.2_Silent_p.T80T|TK2_uc010cdq.2_Silent_p.T80T|TK2_uc010cdr.2_Silent_p.T62T|TK2_uc010viq.1_Silent_p.T135T|TK2_uc010vir.1_Silent_p.T128T	NM_004614	NP_004605	O00142	KITM_HUMAN	thymidine kinase 2, mitochondrial	111					pyrimidine base metabolic process|pyrimidine nucleoside salvage	mitochondrial matrix	ATP binding|phosphotransferase activity, alcohol group as acceptor|thymidine kinase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0736)|Epithelial(162;0.237)														---	---	---	---
MTSS1L	92154	broad.mit.edu	37	16	70710872	70710872	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:70710872C>T	uc002ezj.2	-	10	1002	c.742G>A	c.(742-744)GAC>AAC	p.D248N	MTSS1L_uc002ezk.1_Missense_Mutation_p.D165N	NM_138383	NP_612392	Q765P7	MTSSL_HUMAN	metastasis suppressor 1-like	248	IMD.				filopodium assembly|signal transduction		actin binding|cytoskeletal adaptor activity|SH3 domain binding			central_nervous_system(1)	1																		---	---	---	---
CTU2	348180	broad.mit.edu	37	16	88779164	88779164	+	Silent	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:88779164G>A	uc002flm.2	+	7	636	c.588G>A	c.(586-588)CCG>CCA	p.P196P	CTU2_uc002fln.2_Silent_p.P196P|CTU2_uc010chz.2_Silent_p.P267P|CTU2_uc010cia.2_Silent_p.P109P	NM_001012759	NP_001012777	Q2VPK5	CTU2_HUMAN	cytoplasmic tRNA 2-thiolation protein 2 isoform	196					tRNA thio-modification|tRNA wobble uridine modification	cytoplasm|protein complex|soluble fraction	protein binding			skin(1)	1																		---	---	---	---
FAM101B	359845	broad.mit.edu	37	17	293034	293034	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:293034G>A	uc002frj.2	-	2	630	c.356C>T	c.(355-357)ACG>ATG	p.T119M		NM_182705	NP_874364	Q8N5W9	F101B_HUMAN	hypothetical protein LOC359845	189											0		Myeloproliferative disorder(207;0.204)		UCEC - Uterine corpus endometrioid carcinoma (25;0.0216)														---	---	---	---
Unknown	0	broad.mit.edu	37	17	25783764	25783764	+	IGR	SNP	C	T	T	rs79564666	by1000genomes	TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:25783764C>T								WSB1 (143119 upstream) : KSR1 (15272 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	17	25783779	25783779	+	IGR	SNP	C	A	A	rs143611966	by1000genomes	TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:25783779C>A								WSB1 (143134 upstream) : KSR1 (15257 downstream)																																			---	---	---	---
ABCA6	23460	broad.mit.edu	37	17	67087355	67087355	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:67087355T>C	uc002jhw.1	-	26	3632	c.3457A>G	c.(3457-3459)AGT>GGT	p.S1153G		NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	1153	Helical; (Potential).				transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)																	---	---	---	---
AZI1	22994	broad.mit.edu	37	17	79167799	79167799	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:79167799C>T	uc002jzp.1	-	18	2457	c.2257G>A	c.(2257-2259)GAG>AAG	p.E753K	AZI1_uc002jzm.1_Missense_Mutation_p.E180K|AZI1_uc002jzn.1_Missense_Mutation_p.E750K|AZI1_uc002jzo.1_Missense_Mutation_p.E750K|AZI1_uc010wum.1_Missense_Mutation_p.E753K|AZI1_uc002jzq.2_5'UTR	NM_014984	NP_055799	Q9UPN4	AZI1_HUMAN	5-azacytidine induced 1 isoform a	753					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centrosome|cytosol|intracellular membrane-bounded organelle				central_nervous_system(2)|large_intestine(1)|ovary(1)	4	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)															---	---	---	---
SLC16A3	9123	broad.mit.edu	37	17	80195380	80195380	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:80195380C>A	uc002kea.2	+	4	873	c.734C>A	c.(733-735)CCG>CAG	p.P245Q	SLC16A3_uc002kee.2_Missense_Mutation_p.P245Q|SLC16A3_uc002keb.2_Missense_Mutation_p.P245Q|SLC16A3_uc002kec.2_Missense_Mutation_p.P245Q|SLC16A3_uc002ked.2_Missense_Mutation_p.P245Q	NM_001042422	NP_001035887	O15427	MOT4_HUMAN	solute carrier family 16, member 3	245	Helical; (Potential).				blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	actin cytoskeleton|integral to plasma membrane|membrane fraction|nuclear membrane	secondary active monocarboxylate transmembrane transporter activity|symporter activity			upper_aerodigestive_tract(1)|lung(1)	2	Breast(20;0.00285)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.227)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0149)		Pyruvic acid(DB00119)													---	---	---	---
ZNF750	79755	broad.mit.edu	37	17	80788291	80788291	+	Silent	SNP	C	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:80788291C>A	uc002kga.2	-	3	2210	c.1899G>T	c.(1897-1899)ACG>ACT	p.T633T	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	633						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)															---	---	---	---
C18orf8	29919	broad.mit.edu	37	18	21086966	21086966	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:21086966A>C	uc010xax.1	+	3	333	c.212A>C	c.(211-213)AAG>ACG	p.K71T	C18orf8_uc010xau.1_Intron|C18orf8_uc010xav.1_Missense_Mutation_p.K71T|C18orf8_uc010xaw.1_Intron|C18orf8_uc002kul.2_RNA	NM_013326	NP_037458	Q96DM3	MIC1_HUMAN	colon cancer-associated protein Mic1	71										ovary(1)	1	all_cancers(21;0.000122)|all_epithelial(16;8.08e-07)|Lung NSC(20;0.00206)|all_lung(20;0.00659)|Colorectal(14;0.0202)|Ovarian(20;0.127)																	---	---	---	---
ZNF521	25925	broad.mit.edu	37	18	22807019	22807019	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:22807019T>C	uc002kvk.2	-	4	1110	c.863A>G	c.(862-864)GAG>GGG	p.E288G	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.E288G|ZNF521_uc002kvl.2_Missense_Mutation_p.E68G	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	288	C2H2-type 7.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)							T	PAX5	ALL								---	---	---	---
PIK3C3	5289	broad.mit.edu	37	18	39647433	39647433	+	Missense_Mutation	SNP	G	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:39647433G>C	uc002lap.2	+	24	2663	c.2605G>C	c.(2605-2607)GCT>CCT	p.A869P	PIK3C3_uc010xcl.1_Missense_Mutation_p.A806P|PIK3C3_uc002laq.2_Missense_Mutation_p.A354P	NM_002647	NP_002638	Q8NEB9	PK3C3_HUMAN	catalytic phosphatidylinositol 3-kinase 3	869	PI3K/PI4K.				cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			lung(8)|ovary(1)|breast(1)	10															TSP Lung(28;0.18)			---	---	---	---
TCEB3B	51224	broad.mit.edu	37	18	44560668	44560668	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:44560668C>A	uc002lcr.1	-	1	1321	c.968G>T	c.(967-969)CGG>CTG	p.R323L	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	323					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4																		---	---	---	---
DCC	1630	broad.mit.edu	37	18	50731590	50731590	+	Silent	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:50731590A>G	uc002lfe.1	+	10	2165	c.1578A>G	c.(1576-1578)CAA>CAG	p.Q526Q	DCC_uc010xdr.1_Silent_p.Q374Q|DCC_uc010dpf.1_Silent_p.Q181Q	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	526	Extracellular (Potential).				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)														---	---	---	---
RAX	30062	broad.mit.edu	37	18	56936342	56936342	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:56936342T>G	uc002lhx.2	-	3	1122	c.935A>C	c.(934-936)AAG>ACG	p.K312T	RAX_uc010dpp.2_3'UTR	NM_013435	NP_038463	Q9Y2V3	RX_HUMAN	retina and anterior neural fold homeobox	312					visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1		Lung NSC(161;0.0804)|Colorectal(73;0.0946)		STAD - Stomach adenocarcinoma(84;0.18)														---	---	---	---
RTTN	25914	broad.mit.edu	37	18	67684867	67684867	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:67684867C>T	uc002lkp.2	-	46	6265	c.6197G>A	c.(6196-6198)GGA>GAA	p.G2066E	RTTN_uc002lko.2_RNA|RTTN_uc010xfb.1_Missense_Mutation_p.G1154E|RTTN_uc002lkn.2_Missense_Mutation_p.G56E|RTTN_uc010dqp.2_Missense_Mutation_p.G318E	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	2066							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)																---	---	---	---
APC2	10297	broad.mit.edu	37	19	1465645	1465645	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:1465645A>G	uc002lsr.1	+	15	2553	c.2345A>G	c.(2344-2346)GAT>GGT	p.D782G	APC2_uc002lss.1_Missense_Mutation_p.D364G|APC2_uc002lst.1_Missense_Mutation_p.D782G|APC2_uc002lsu.1_Missense_Mutation_p.D781G|C19orf25_uc010xgn.1_Intron	NM_005883	NP_005874	O95996	APC2_HUMAN	adenomatosis polyposis coli 2	782					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|pancreas(1)	4		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
DOT1L	84444	broad.mit.edu	37	19	2226981	2226981	+	Silent	SNP	C	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:2226981C>A	uc002lvb.3	+	27	4497	c.4461C>A	c.(4459-4461)TCC>TCA	p.S1487S	DOT1L_uc002lvc.1_Silent_p.S781S	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	1487						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
FZR1	51343	broad.mit.edu	37	19	3526252	3526252	+	Intron	SNP	C	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:3526252C>A	uc010dtk.2	+						FZR1_uc002lxt.2_Intron|FZR1_uc002lxv.2_Intron	NM_001136198	NP_001129670			Fzr1 protein isoform 1						activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|DNA repair|G2/M transition DNA damage checkpoint|mitosis|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding			lung(1)|kidney(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
ARRDC5	645432	broad.mit.edu	37	19	4891231	4891231	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4891231C>T	uc002mbm.2	-	3	856	c.856G>A	c.(856-858)GGT>AGT	p.G286S		NM_001080523	NP_001073992	A6NEK1	ARRD5_HUMAN	arrestin domain containing 5	286					signal transduction						0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0257)														---	---	---	---
DENND1C	79958	broad.mit.edu	37	19	6481686	6481686	+	Intron	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6481686T>G	uc002mfe.2	-						DENND1C_uc002mfd.2_5'Flank|DENND1C_uc010xje.1_Intron	NM_024898	NP_079174			DENN/MADD domain containing 1C							clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			large_intestine(1)	1																		---	---	---	---
MUC16	94025	broad.mit.edu	37	19	9018538	9018538	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9018538A>C	uc002mkp.2	-	24	37840	c.37636T>G	c.(37636-37638)TTC>GTC	p.F12546V		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12548	SEA 4.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57																		---	---	---	---
OR7G1	125962	broad.mit.edu	37	19	9226256	9226256	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9226256G>T	uc002mks.1	-	1	184	c.184C>A	c.(184-186)CTT>ATT	p.L62I		NM_001005192	NP_001005192	Q8NGA0	OR7G1_HUMAN	olfactory receptor, family 7, subfamily G,	62	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2																		---	---	---	---
ZNF559	84527	broad.mit.edu	37	19	9453044	9453044	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9453044T>G	uc002mlg.2	+	7	1564	c.917T>G	c.(916-918)TTT>TGT	p.F306C	ZNF559_uc002mlf.2_Missense_Mutation_p.F75C|ZNF559_uc010dwl.1_Missense_Mutation_p.F75C|ZNF559_uc010xkn.1_Missense_Mutation_p.F298C|ZNF559_uc010dwm.1_3'UTR|ZNF559_uc002mle.3_Missense_Mutation_p.F370C|ZNF559_uc010dwk.1_Missense_Mutation_p.F75C|ZNF559_uc002mld.2_3'UTR|ZNF559_uc010dwo.1_Intron|ZNF177_uc002mli.2_Intron|ZNF177_uc002mlj.2_Intron	NM_032497	NP_115886	Q9BR84	ZN559_HUMAN	zinc finger protein 559	306	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1																		---	---	---	---
TRMT1	55621	broad.mit.edu	37	19	13226979	13226979	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:13226979C>T	uc002mwj.2	-	1	485	c.235G>A	c.(235-237)GAA>AAA	p.E79K	NACC1_uc002mwm.2_5'Flank|TRMT1_uc002mwk.2_Missense_Mutation_p.E79K|TRMT1_uc002mwl.3_Missense_Mutation_p.E79K|TRMT1_uc010xmz.1_Intron	NM_017722	NP_060192	Q9NXH9	TRM1_HUMAN	tRNA methyltransferase 1 isoform 1	79							RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(19;6.08e-22)	GBM - Glioblastoma multiforme(1328;0.0356)														---	---	---	---
SLC1A6	6511	broad.mit.edu	37	19	15079169	15079169	+	Missense_Mutation	SNP	C	T	T	rs149934975		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:15079169C>T	uc002naa.1	-	3	502	c.494G>A	c.(493-495)CGG>CAG	p.R165Q	SLC1A6_uc010dzu.1_Missense_Mutation_p.R165Q|SLC1A6_uc010xod.1_Intron|SLC1A6_uc002nab.2_Missense_Mutation_p.R165Q|SLC1A6_uc002nac.2_Missense_Mutation_p.R165Q|SLC1A6_uc002nad.1_Missense_Mutation_p.R165Q	NM_005071	NP_005062	P48664	EAA4_HUMAN	solute carrier family 1 (high affinity	165	Extracellular (Potential).				synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			pancreas(3)|ovary(2)|skin(1)	6					L-Glutamic Acid(DB00142)													---	---	---	---
CYP4F2	8529	broad.mit.edu	37	19	15989663	15989663	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:15989663T>G	uc002nbs.1	-	13	1531	c.1481A>C	c.(1480-1482)GAC>GCC	p.D494A	CYP4F2_uc010xot.1_Missense_Mutation_p.D345A	NM_001082	NP_001073	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F,	494					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			ovary(1)|skin(1)	2																		---	---	---	---
JAK3	3718	broad.mit.edu	37	19	17951088	17951088	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17951088C>T	uc002nhn.3	-	9	1305	c.1205G>A	c.(1204-1206)CGC>CAC	p.R402H	JAK3_uc010ebh.2_RNA|JAK3_uc002nho.2_Missense_Mutation_p.R402H|JAK3_uc010xpx.1_Missense_Mutation_p.R402H	NM_000215	NP_000206	P52333	JAK3_HUMAN	Janus kinase 3	402	SH2; atypical.				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			haematopoietic_and_lymphoid_tissue(40)|lung(5)|breast(5)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	56							2	Mis		acute megakaryocytic leukemia|								---	---	---	---
ISYNA1	51477	broad.mit.edu	37	19	18547246	18547246	+	Missense_Mutation	SNP	G	A	A	rs138096546		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:18547246G>A	uc002njd.1	-	6	703	c.653C>T	c.(652-654)GCG>GTG	p.A218V	ISYNA1_uc002nja.1_Missense_Mutation_p.A90V|ISYNA1_uc002njb.1_Missense_Mutation_p.A136V|ISYNA1_uc002njc.1_Missense_Mutation_p.A68V|ISYNA1_uc010xqh.1_Missense_Mutation_p.A16V|ISYNA1_uc002nje.1_Missense_Mutation_p.A164V|ISYNA1_uc002njf.1_Missense_Mutation_p.A68V	NM_016368	NP_057452	Q9NPH2	INO1_HUMAN	inositol-3-phosphate synthase 1	218					inositol biosynthetic process|phospholipid biosynthetic process	cytoplasm	binding|inositol-3-phosphate synthase activity			ovary(1)|pancreas(1)	2																		---	---	---	---
ZNF536	9745	broad.mit.edu	37	19	31040061	31040061	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:31040061G>T	uc002nsu.1	+	4	3673	c.3535G>T	c.(3535-3537)GAT>TAT	p.D1179Y	ZNF536_uc010edd.1_Missense_Mutation_p.D1179Y	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1179					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)																	---	---	---	---
SPINT2	10653	broad.mit.edu	37	19	38779813	38779813	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:38779813G>A	uc002ohr.1	+	4	704	c.373G>A	c.(373-375)GAT>AAT	p.D125N	SPINT2_uc002ohs.1_Missense_Mutation_p.D68N	NM_021102	NP_066925	O43291	SPIT2_HUMAN	serine protease inhibitor, Kunitz type, 2	125	Extracellular (Potential).				cellular component movement	cytoplasm|extracellular region|integral to membrane|soluble fraction	serine-type endopeptidase inhibitor activity				0	all_cancers(60;6.83e-07)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)															---	---	---	---
ATP1A3	478	broad.mit.edu	37	19	42479939	42479939	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42479939A>G	uc002osg.2	-	16	2259	c.2105T>C	c.(2104-2106)GTG>GCG	p.V702A	ATP1A3_uc010xwf.1_Missense_Mutation_p.V713A|ATP1A3_uc010xwg.1_Missense_Mutation_p.V672A|ATP1A3_uc010xwh.1_Missense_Mutation_p.V715A|ATP1A3_uc002osh.2_Missense_Mutation_p.V702A	NM_152296	NP_689509	P13637	AT1A3_HUMAN	Na+/K+ -ATPase alpha 3 subunit	702	Cytoplasmic (Potential).				ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(1)|pancreas(1)	2																		---	---	---	---
TRPM4	54795	broad.mit.edu	37	19	49705384	49705384	+	Silent	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49705384C>T	uc002pmw.2	+	20	3189	c.3117C>T	c.(3115-3117)CTC>CTT	p.L1039L	TRPM4_uc010emu.2_Silent_p.L894L|TRPM4_uc010yak.1_Silent_p.L503L|TRPM4_uc002pmx.2_Silent_p.L865L|TRPM4_uc010emv.2_Silent_p.L924L|TRPM4_uc010yal.1_Silent_p.L685L|TRPM4_uc002pmy.2_Silent_p.L381L	NM_017636	NP_060106	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel,	1039	Helical; (Potential).				dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			ovary(1)|central_nervous_system(1)	2		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)														---	---	---	---
PTH2	113091	broad.mit.edu	37	19	49926533	49926533	+	Missense_Mutation	SNP	G	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49926533G>C	uc002pnn.1	-	1	166	c.64C>G	c.(64-66)CTG>GTG	p.L22V		NM_178449	NP_848544	Q96A98	TIP39_HUMAN	parathyroid hormone 2 preproprotein	22					neuropeptide signaling pathway	extracellular region					0				OV - Ovarian serous cystadenocarcinoma(262;0.0015)|GBM - Glioblastoma multiforme(486;0.044)|Lung(386;0.0785)|LUSC - Lung squamous cell carcinoma(496;0.0836)														---	---	---	---
POLD1	5424	broad.mit.edu	37	19	50910659	50910659	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50910659G>A	uc002psb.3	+	14	1818	c.1762G>A	c.(1762-1764)GAG>AAG	p.E588K	POLD1_uc002psc.3_Missense_Mutation_p.E588K|POLD1_uc010enx.2_RNA|POLD1_uc010eny.2_Missense_Mutation_p.E588K	NM_002691	NP_002682	P28340	DPOD1_HUMAN	DNA-directed DNA polymerase delta 1	588					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|response to UV|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm|nucleotide-excision repair complex	3'-5'-exodeoxyribonuclease activity|chromatin binding|DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding|protein binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2		all_neural(266;0.0571)		OV - Ovarian serous cystadenocarcinoma(262;0.00794)|GBM - Glioblastoma multiforme(134;0.0195)									DNA_polymerases_(catalytic_subunits)					---	---	---	---
ZNF610	162963	broad.mit.edu	37	19	52857592	52857592	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:52857592A>C	uc002pyx.3	+	5	685	c.279A>C	c.(277-279)AAA>AAC	p.K93N	ZNF610_uc002pyy.3_Missense_Mutation_p.K93N|ZNF610_uc002pyz.3_Intron|ZNF610_uc002pza.2_Missense_Mutation_p.K93N	NM_001161426	NP_001154898	Q8N9Z0	ZN610_HUMAN	zinc finger protein 610 isoform a	93	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3				OV - Ovarian serous cystadenocarcinoma(262;0.00396)|GBM - Glioblastoma multiforme(134;0.00434)														---	---	---	---
ZNF347	84671	broad.mit.edu	37	19	53645784	53645784	+	Missense_Mutation	SNP	T	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:53645784T>A	uc002qbb.1	-	5	366	c.297A>T	c.(295-297)AAA>AAT	p.K99N	ZNF347_uc010eql.1_Missense_Mutation_p.K100N|ZNF347_uc002qbc.1_Missense_Mutation_p.K100N	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	99					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)														---	---	---	---
KIR2DL1	3802	broad.mit.edu	37	19	55284967	55284967	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55284967T>G	uc002qhb.1	+	3	291	c.253T>G	c.(253-255)TTC>GTC	p.F85V	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR2DL3_uc010erw.1_Intron|KIR2DL1_uc002qgz.1_Intron|KIR2DL3_uc002qha.1_Intron|KIR3DP1_uc010yfi.1_Intron|KIR2DL1_uc010erz.1_Missense_Mutation_p.F85V	NM_014218	NP_055033	P43626	KI2L1_HUMAN	killer cell immunoglobulin-like receptor, two	85	Extracellular (Potential).|Ig-like C2-type 1.				immune response|natural killer cell inhibitory signaling pathway	integral to plasma membrane	protein binding|receptor activity				0				GBM - Glioblastoma multiforme(193;0.0192)														---	---	---	---
NLRP9	338321	broad.mit.edu	37	19	56243496	56243496	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:56243496T>G	uc002qly.2	-	2	1729	c.1701A>C	c.(1699-1701)GAA>GAC	p.E567D		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	567						cytoplasm	ATP binding			skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)														---	---	---	---
DEFB132	400830	broad.mit.edu	37	20	238424	238424	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:238424A>G	uc002wdb.2	+	1	48	c.5A>G	c.(4-6)AAG>AGG	p.K2R		NM_207469	NP_997352	Q7Z7B7	DB132_HUMAN	beta-defensin 32 precursor	2					defense response to bacterium	extracellular region					0																		---	---	---	---
RBCK1	10616	broad.mit.edu	37	20	402813	402813	+	Silent	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:402813G>A	uc002wdp.3	+	8	1653	c.960G>A	c.(958-960)GAG>GAA	p.E320E	RBCK1_uc010zpm.1_RNA|RBCK1_uc002wdq.3_Silent_p.E278E|RBCK1_uc010fzy.2_RNA|RBCK1_uc002wdr.3_Silent_p.E150E	NM_031229	NP_112506	Q9BYM8	HOIL1_HUMAN	RanBP-type and C3HC4-type zinc finger containing	320	RING-type.				interspecies interaction between organisms|negative regulation of NF-kappaB transcription factor activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|proteasomal ubiquitin-dependent protein catabolic process|protein linear polyubiquitination|T cell receptor signaling pathway	LUBAC complex	protein binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0		all_epithelial(17;0.172)|Lung NSC(37;0.191)|Breast(17;0.231)																---	---	---	---
ZNF343	79175	broad.mit.edu	37	20	2463798	2463798	+	3'UTR	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:2463798T>C	uc002wge.1	-	6					ZNF343_uc010gao.1_3'UTR|ZNF343_uc002wgd.1_3'UTR	NM_024325	NP_077301			zinc finger protein 343						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3																		---	---	---	---
PAX1	5075	broad.mit.edu	37	20	21695269	21695269	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:21695269C>T	uc002wsj.2	+	5	1487	c.1433C>T	c.(1432-1434)GCG>GTG	p.A478V	PAX1_uc010zsl.1_3'UTR|PAX1_uc010zsm.1_3'UTR	NM_006192	NP_006183	P15863	PAX1_HUMAN	paired box 1	478					regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			upper_aerodigestive_tract(1)|kidney(1)	2																		---	---	---	---
SSTR4	6754	broad.mit.edu	37	20	23016968	23016968	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:23016968T>G	uc002wsr.2	+	1	912	c.848T>G	c.(847-849)CTC>CGC	p.L283R		NM_001052	NP_001043	P31391	SSR4_HUMAN	somatostatin receptor 4	283	Extracellular (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			ovary(1)	1	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)																	---	---	---	---
CD93	22918	broad.mit.edu	37	20	23064893	23064893	+	Intron	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:23064893T>C	uc002wsv.2	-							NM_012072	NP_036204			CD93 antigen precursor						cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			large_intestine(2)	2	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)																	---	---	---	---
NAPB	63908	broad.mit.edu	37	20	23383641	23383641	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:23383641T>C	uc002wta.2	-	2	284	c.167A>G	c.(166-168)AAA>AGA	p.K56R	NAPB_uc002wtc.2_5'UTR|NAPB_uc002wtb.2_Missense_Mutation_p.K56R|NAPB_uc002wtd.3_RNA|NAPB_uc010zst.1_Missense_Mutation_p.K56R	NM_022080	NP_071363	Q9H115	SNAB_HUMAN	N-ethylmaleimide-sensitive factor attachment	56					intracellular protein transport|vesicle-mediated transport	membrane				ovary(1)	1	Lung NSC(19;0.0646)|Colorectal(13;0.0993)|all_lung(19;0.143)																	---	---	---	---
NINL	22981	broad.mit.edu	37	20	25462679	25462679	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:25462679G>T	uc002wux.1	-	14	1809	c.1735C>A	c.(1735-1737)CTG>ATG	p.L579M	NINL_uc010gdn.1_Missense_Mutation_p.L579M|NINL_uc010gdo.1_Missense_Mutation_p.L362M	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	579	Potential.				G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5																		---	---	---	---
VSTM2L	128434	broad.mit.edu	37	20	36572448	36572448	+	Silent	SNP	C	T	T	rs150645578		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:36572448C>T	uc002xhk.3	+	4	662	c.408C>T	c.(406-408)GAC>GAT	p.D136D		NM_080607	NP_542174	Q96N03	VTM2L_HUMAN	V-set and transmembrane domain containing 2 like	136	Ig-like.									ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(115;0.00878)																---	---	---	---
PREX1	57580	broad.mit.edu	37	20	47267989	47267989	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:47267989C>A	uc002xtw.1	-	22	2623	c.2600G>T	c.(2599-2601)TGC>TTC	p.C867F	PREX1_uc002xtv.1_Missense_Mutation_p.C164F	NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	867					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)															---	---	---	---
SALL4	57167	broad.mit.edu	37	20	50406626	50406626	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:50406626T>C	uc002xwh.3	-	2	2497	c.2396A>G	c.(2395-2397)AAG>AGG	p.K799R	SALL4_uc010gii.2_Intron|SALL4_uc002xwi.3_Intron	NM_020436	NP_065169	Q9UJQ4	SALL4_HUMAN	sal-like 4	799					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2																		---	---	---	---
CASS4	57091	broad.mit.edu	37	20	55027707	55027707	+	Missense_Mutation	SNP	A	T	T	rs145762733		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:55027707A>T	uc002xxp.2	+	6	1700	c.1475A>T	c.(1474-1476)GAA>GTA	p.E492V	CASS4_uc002xxq.3_Missense_Mutation_p.E492V|CASS4_uc002xxr.2_Missense_Mutation_p.E492V|CASS4_uc010zze.1_Missense_Mutation_p.E438V|CASS4_uc010gio.2_Intron	NM_001164116	NP_001157588	Q9NQ75	CASS4_HUMAN	HEF-like protein isoform a	492					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			ovary(2)|skin(1)	3																		---	---	---	---
CDH26	60437	broad.mit.edu	37	20	58564160	58564160	+	Missense_Mutation	SNP	G	T	T	rs143325825		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:58564160G>T	uc002ybe.2	+	9	1525	c.1225G>T	c.(1225-1227)GCC>TCC	p.A409S	CDH26_uc002ybf.1_5'UTR|CDH26_uc010zzy.1_RNA	NM_177980	NP_817089	Q8IXH8	CAD26_HUMAN	cadherin-like 26 isoform a	409	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|central_nervous_system(1)	4	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)															---	---	---	---
PRPF6	24148	broad.mit.edu	37	20	62658332	62658332	+	Intron	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:62658332C>T	uc002yho.2	+						PRPF6_uc002yhp.2_Intron	NM_012469	NP_036601			PRP6 pre-mRNA processing factor 6 homolog						assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			ovary(2)	2	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)																	---	---	---	---
LIPI	149998	broad.mit.edu	37	21	15561478	15561478	+	Silent	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:15561478T>C	uc002yjm.2	-	2	382	c.372A>G	c.(370-372)GAA>GAG	p.E124E	LIPI_uc010gkw.1_Silent_p.E57E	NM_198996	NP_945347	Q6XZB0	LIPI_HUMAN	lipase, member I	103					lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			ovary(2)	2				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)														---	---	---	---
ADAMTS5	11096	broad.mit.edu	37	21	28296442	28296442	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:28296442T>G	uc002ymg.2	-	8	3452	c.2723A>C	c.(2722-2724)AAG>ACG	p.K908T		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	908	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4																		---	---	---	---
TIAM1	7074	broad.mit.edu	37	21	32638350	32638350	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:32638350T>G	uc002yow.1	-	5	1411	c.939A>C	c.(937-939)CAA>CAC	p.Q313H	TIAM1_uc011adk.1_Missense_Mutation_p.Q313H|TIAM1_uc011adl.1_Missense_Mutation_p.Q313H|TIAM1_uc002yox.1_Intron	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	313					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10																		---	---	---	---
HUNK	30811	broad.mit.edu	37	21	33371499	33371499	+	3'UTR	SNP	T	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:33371499T>A	uc002yph.2	+	11						NM_014586	NP_055401			hormonally upregulated Neu-associated kinase						multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			stomach(1)|skin(1)	2																		---	---	---	---
CECR1	51816	broad.mit.edu	37	22	17688091	17688091	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:17688091A>C	uc002zmk.1	-	2	624	c.412T>G	c.(412-414)TTC>GTC	p.F138V	CECR1_uc010gqu.1_Missense_Mutation_p.F138V|CECR1_uc011agi.1_Missense_Mutation_p.F96V|CECR1_uc011agj.1_Missense_Mutation_p.F96V	NM_017424	NP_059120	Q9NZK5	CECR1_HUMAN	cat eye syndrome critical region protein 1	138	PRB domain.				adenosine catabolic process|hypoxanthine salvage|inosine biosynthetic process|multicellular organismal development|purine ribonucleoside monophosphate biosynthetic process	extracellular space|Golgi apparatus	adenosine deaminase activity|adenosine receptor binding|growth factor activity|heparin binding|protein homodimerization activity|proteoglycan binding|zinc ion binding			ovary(1)	1		all_epithelial(15;0.0152)|Lung NSC(13;0.0875)|all_lung(157;0.106)																---	---	---	---
GNAZ	2781	broad.mit.edu	37	22	23437912	23437912	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:23437912A>C	uc002zwu.1	+	2	567	c.30A>C	c.(28-30)AAA>AAC	p.K10N	RTDR1_uc002zwt.2_Intron	NM_002073	NP_002064	P19086	GNAZ_HUMAN	guanine nucleotide binding protein, alpha z	10						endoplasmic reticulum|heterotrimeric G-protein complex|nuclear envelope	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|metabotropic serotonin receptor binding|receptor signaling protein activity			kidney(1)|skin(1)	2	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.166)														---	---	---	---
ZNRF3	84133	broad.mit.edu	37	22	29445296	29445296	+	Missense_Mutation	SNP	A	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:29445296A>T	uc003aeg.2	+	8	992	c.827A>T	c.(826-828)AAC>ATC	p.N276I	ZNRF3_uc003aeh.1_Missense_Mutation_p.N276I	NM_032173	NP_115549	Q9ULT6	ZNRF3_HUMAN	zinc and ring finger 3	376	Cytoplasmic (Potential).					integral to membrane	zinc ion binding			ovary(1)	1																		---	---	---	---
EFCAB6	64800	broad.mit.edu	37	22	44063009	44063009	+	Missense_Mutation	SNP	T	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:44063009T>A	uc003bdy.1	-	17	2173	c.1958A>T	c.(1957-1959)AAA>ATA	p.K653I	EFCAB6_uc003bdz.1_Missense_Mutation_p.K501I|EFCAB6_uc010gzi.1_Missense_Mutation_p.K501I|EFCAB6_uc010gzj.1_5'UTR|EFCAB6_uc010gzk.1_RNA	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	653	EF-hand 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)																---	---	---	---
PKDREJ	10343	broad.mit.edu	37	22	46655349	46655349	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:46655349C>T	uc003bhh.2	-	1	3871	c.3871G>A	c.(3871-3873)GGG>AGG	p.G1291R		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1291	Cytoplasmic (Potential).|PLAT.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)														---	---	---	---
STS	412	broad.mit.edu	37	X	7268091	7268091	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:7268091C>A	uc004cry.3	+	10	1786	c.1541C>A	c.(1540-1542)CCA>CAA	p.P514Q		NM_000351	NP_000342	P08842	STS_HUMAN	steryl-sulfatase precursor	514	Lumenal.				female pregnancy|steroid catabolic process	endoplasmic reticulum membrane|endosome|Golgi apparatus|integral to membrane|lysosome|microsome|plasma membrane	metal ion binding|steryl-sulfatase activity			central_nervous_system(1)	1		Colorectal(8;0.0136)|Medulloblastoma(8;0.184)			Estrone(DB00655)									Ichthyosis				---	---	---	---
WWC3	55841	broad.mit.edu	37	X	10047829	10047829	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:10047829T>C	uc004csx.3	+	5	560	c.362T>C	c.(361-363)GTG>GCG	p.V121A	WWC3_uc010nds.2_5'UTR|WWC3_uc010ndt.2_RNA	NM_015691	NP_056506	Q9ULE0	WWC3_HUMAN	WWC family member 3	121	Potential.									ovary(4)	4																		---	---	---	---
REPS2	9185	broad.mit.edu	37	X	17080602	17080602	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:17080602T>C	uc004cxv.1	+	9	1327	c.1156T>C	c.(1156-1158)TAT>CAT	p.Y386H	REPS2_uc004cxw.1_Missense_Mutation_p.Y385H|REPS2_uc011miw.1_Missense_Mutation_p.Y245H	NM_004726	NP_004717	Q8NFH8	REPS2_HUMAN	RALBP1 associated Eps domain containing 2	386					epidermal growth factor receptor signaling pathway|protein complex assembly	cytoplasm	calcium ion binding|protein binding			skin(2)|central_nervous_system(1)	3	Hepatocellular(33;0.183)																	---	---	---	---
MAOB	4129	broad.mit.edu	37	X	43662581	43662581	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:43662581T>G	uc004dfz.3	-	4	526	c.350A>C	c.(349-351)AAC>ACC	p.N117T	MAOB_uc011mkx.1_Missense_Mutation_p.N101T|MAOB_uc011mky.1_Missense_Mutation_p.N101T	NM_000898	NP_000889	P27338	AOFB_HUMAN	monoamine oxidase B	117	Cytoplasmic.				xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	electron carrier activity|primary amine oxidase activity			ovary(1)|central_nervous_system(1)	2					Amantadine(DB00915)|Bupropion(DB01156)|Carbidopa(DB00190)|Citalopram(DB00215)|Dopamine(DB00988)|Entacapone(DB00494)|Furazolidone(DB00614)|Ginkgo biloba(DB01381)|Ibuprofen(DB01050)|Imipramine(DB00458)|Iproniazid(DB04818)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Maprotiline(DB00934)|Meclizine(DB00737)|Moclobemide(DB01171)|Nicotine(DB00184)|Pargyline(DB01626)|Phenelzine(DB00780)|Phentermine(DB00191)|Rasagiline(DB01367)|Selegiline(DB01037)|Tranylcypromine(DB00752)													---	---	---	---
ZNF630	57232	broad.mit.edu	37	X	47918755	47918755	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:47918755T>G	uc004div.3	-	5	1328	c.1076A>C	c.(1075-1077)AAG>ACG	p.K359T	ZNF630_uc010nhz.1_Intron|ZNF630_uc004diw.2_Missense_Mutation_p.K235T	NM_001037735	NP_001032824	Q2M218	ZN630_HUMAN	zinc finger protein 630	359	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|lung(1)	2																		---	---	---	---
KIAA2022	340533	broad.mit.edu	37	X	73961294	73961294	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:73961294T>G	uc004eby.2	-	3	3715	c.3098A>C	c.(3097-3099)AAG>ACG	p.K1033T		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	1033					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15																		---	---	---	---
BTK	695	broad.mit.edu	37	X	100630128	100630128	+	Intron	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:100630128T>G	uc004ehg.2	-						BTK_uc010nnn.2_Intron|BTK_uc010nno.2_Intron|BTK_uc004ehi.2_Intron	NM_000061	NP_000052			Bruton agammaglobulinemia tyrosine kinase						calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding			lung(3)|central_nervous_system(2)|ovary(1)	6														Agammaglobulinemia_X-linked				---	---	---	---
TRPC5	7224	broad.mit.edu	37	X	111022219	111022219	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:111022219A>C	uc004epl.1	-	10	3145	c.2226T>G	c.(2224-2226)AAT>AAG	p.N742K		NM_012471	NP_036603	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel,	742	Cytoplasmic (Potential).				axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			urinary_tract(1)	1																		---	---	---	---
USP26	83844	broad.mit.edu	37	X	132160633	132160633	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:132160633A>C	uc010nrm.1	-	6	2086	c.1616T>G	c.(1615-1617)GTC>GGC	p.V539G	USP26_uc011mvf.1_Missense_Mutation_p.V539G	NM_031907	NP_114113	Q9BXU7	UBP26_HUMAN	ubiquitin-specific protease 26	539					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(3)|central_nervous_system(3)|kidney(1)|liver(1)	8	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
ARHGEF6	9459	broad.mit.edu	37	X	135825841	135825841	+	Silent	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:135825841G>A	uc004fab.2	-	5	1026	c.564C>T	c.(562-564)TAC>TAT	p.Y188Y	ARHGEF6_uc011mwd.1_Silent_p.Y34Y|ARHGEF6_uc011mwe.1_Silent_p.Y34Y	NM_004840	NP_004831	Q15052	ARHG6_HUMAN	Rac/Cdc42 guanine nucleotide exchange factor 6	188	SH3.				apoptosis|cell junction assembly|induction of apoptosis by extracellular signals|JNK cascade|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity				0	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
ARHGAP4	393	broad.mit.edu	37	X	153176006	153176006	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-10A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153176006C>T	uc004fjk.1	-	16	1918	c.1876G>A	c.(1876-1878)GCG>ACG	p.A626T	ARHGAP4_uc004fjj.1_5'UTR|ARHGAP4_uc011mzf.1_Missense_Mutation_p.A603T|ARHGAP4_uc004fjl.1_Missense_Mutation_p.A666T|ARHGAP4_uc010nup.1_Intron	NM_001666	NP_001657	P98171	RHG04_HUMAN	Rho GTPase activating protein 4 isoform 2	626	Rho-GAP.				apoptosis|cytoskeleton organization|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|Rho protein signal transduction	cytosol|focal adhesion|nucleus	Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			central_nervous_system(1)	1	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
MEGF6	1953	broad.mit.edu	37	1	3427384	3427384	+	Silent	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:3427384G>A	uc001akl.2	-	10	1424	c.1197C>T	c.(1195-1197)GCC>GCT	p.A399A	MEGF6_uc001akk.2_Silent_p.A294A	NM_001409	NP_001400	O75095	MEGF6_HUMAN	EGF-like-domain, multiple 3 precursor	399	EGF-like 7.					extracellular region	calcium ion binding			large_intestine(1)	1	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)														---	---	---	---
PER3	8863	broad.mit.edu	37	1	7886602	7886602	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:7886602T>C	uc001aoo.2	+	16	2171	c.1996T>C	c.(1996-1998)TCG>CCG	p.S666P	PER3_uc009vmg.1_Missense_Mutation_p.S674P|PER3_uc009vmh.1_Missense_Mutation_p.S667P|PER3_uc001aop.2_Missense_Mutation_p.S674P|PER3_uc010nzw.1_Missense_Mutation_p.S355P	NM_016831	NP_058515	P56645	PER3_HUMAN	period 3	666	CSNK1E binding domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			ovary(1)|pancreas(1)|skin(1)	3	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
PRAMEF1	65121	broad.mit.edu	37	1	12855688	12855688	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:12855688A>C	uc001auj.1	+	4	1071	c.968A>C	c.(967-969)AAG>ACG	p.K323T		NM_023013	NP_075389	O95521	PRAM1_HUMAN	PRAME family member 1	323	LRR 1.										0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
DLGAP3	58512	broad.mit.edu	37	1	35369893	35369893	+	Silent	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:35369893A>G	uc001byc.2	-	1	1092	c.1092T>C	c.(1090-1092)ACT>ACC	p.T364T		NM_001080418	NP_001073887	O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated	364					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				ovary(3)	3		Myeloproliferative disorder(586;0.0393)																---	---	---	---
MRPS15	64960	broad.mit.edu	37	1	36926911	36926911	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:36926911A>G	uc001cas.2	-	4	418	c.254T>C	c.(253-255)GTT>GCT	p.V85A		NM_031280	NP_112570	P82914	RT15_HUMAN	mitochondrial ribosomal protein S15 precursor	85					translation	mitochondrial small ribosomal subunit|nuclear membrane	structural constituent of ribosome			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)																---	---	---	---
ZNF643	65243	broad.mit.edu	37	1	40929053	40929053	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:40929053A>G	uc001cfn.1	+	5	1694	c.1397A>G	c.(1396-1398)CAG>CGG	p.Q466R	ZNF643_uc001cfl.1_Missense_Mutation_p.Q364R|ZNF643_uc001cfm.1_Missense_Mutation_p.Q332R	NM_023070	NP_075558	Q9UJL9	ZN643_HUMAN	zinc finger protein 643	466	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;5.25e-18)															---	---	---	---
PGM1	5236	broad.mit.edu	37	1	64100648	64100648	+	Silent	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:64100648G>A	uc001dbh.2	+	5	1044	c.831G>A	c.(829-831)AAG>AAA	p.K277K	PGM1_uc010ooy.1_Silent_p.K80K|PGM1_uc010ooz.1_Silent_p.K295K	NM_002633	NP_002624	P36871	PGM1_HUMAN	phosphoglucomutase 1	277					cellular calcium ion homeostasis|galactose catabolic process|glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity			ovary(2)|kidney(1)	3																		---	---	---	---
WDR63	126820	broad.mit.edu	37	1	85551632	85551632	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:85551632A>C	uc001dkt.2	+	7	850	c.659A>C	c.(658-660)AAT>ACT	p.N220T	WDR63_uc009wcl.2_Missense_Mutation_p.N220T	NM_145172	NP_660155	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	220										upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)														---	---	---	---
COL24A1	255631	broad.mit.edu	37	1	86227202	86227202	+	Intron	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:86227202A>C	uc001dlj.2	-						COL24A1_uc001dli.2_Intron|COL24A1_uc010osd.1_Intron|COL24A1_uc001dlk.2_Intron|COL24A1_uc010ose.1_Intron|COL24A1_uc010osf.1_Intron	NM_152890	NP_690850			collagen, type XXIV, alpha 1 precursor						cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)														---	---	---	---
NGF	4803	broad.mit.edu	37	1	115828920	115828920	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:115828920T>G	uc001efu.1	-	3	666	c.497A>C	c.(496-498)AAC>ACC	p.N166T		NM_002506	NP_002497	P01138	NGF_HUMAN	nerve growth factor, beta polypeptide precursor	166					activation of MAPKK activity|activation of phospholipase C activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of cell cycle|nerve growth factor processing|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|Golgi lumen	growth factor activity|nerve growth factor receptor binding			upper_aerodigestive_tract(2)	2	Lung SC(450;0.211)	all_cancers(81;1.07e-06)|all_epithelial(167;4.43e-06)|all_lung(203;2.86e-05)|Lung NSC(69;4.99e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)	Clenbuterol(DB01407)													---	---	---	---
POGZ	23126	broad.mit.edu	37	1	151384863	151384863	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:151384863T>G	uc001eyd.1	-	11	1994	c.1688A>C	c.(1687-1689)AAG>ACG	p.K563T	POGZ_uc001eye.1_Missense_Mutation_p.K510T|POGZ_uc010pdb.1_Missense_Mutation_p.K554T|POGZ_uc001eyf.1_Missense_Mutation_p.K510T|POGZ_uc010pdc.1_Missense_Mutation_p.K501T|POGZ_uc009wmv.1_Missense_Mutation_p.K468T|POGZ_uc010pdd.1_Missense_Mutation_p.K54T	NM_015100	NP_055915	Q7Z3K3	POGZ_HUMAN	pogo transposable element with ZNF domain	563	C2H2-type 4.				cell division|kinetochore assembly|mitotic sister chromatid cohesion|regulation of transcription, DNA-dependent	cytoplasm|nuclear chromatin	DNA binding|protein binding|zinc ion binding			ovary(3)	3	Lung SC(34;0.00471)|Ovarian(49;0.00672)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)															---	---	---	---
TCHH	7062	broad.mit.edu	37	1	152080591	152080591	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:152080591C>T	uc001ezp.2	-	2	5102	c.5102G>A	c.(5101-5103)CGC>CAC	p.R1701H	TCHH_uc009wne.1_Missense_Mutation_p.R1701H	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1701	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)															---	---	---	---
SH2D2A	9047	broad.mit.edu	37	1	156779580	156779580	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156779580A>G	uc001fqd.2	-	6	727	c.587T>C	c.(586-588)CTT>CCT	p.L196P	SH2D2A_uc001fqc.1_Missense_Mutation_p.L168P|SH2D2A_uc009wsh.2_Missense_Mutation_p.L206P|SH2D2A_uc001fqe.2_Missense_Mutation_p.L178P|SH2D2A_uc010phs.1_Missense_Mutation_p.L196P	NM_003975	NP_003966	Q9NP31	SH22A_HUMAN	SH2 domain protein 2A isoform 2	196	Pro-rich.				angiogenesis|cell differentiation|signal transduction	cytoplasm|soluble fraction	SH3 domain binding|SH3/SH2 adaptor activity				0	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)																	---	---	---	---
FCRL3	115352	broad.mit.edu	37	1	157668201	157668201	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:157668201C>T	uc001frb.2	-	4	563	c.271G>A	c.(271-273)GAT>AAT	p.D91N	FCRL3_uc001fqx.3_RNA|FCRL3_uc001fqy.3_RNA|FCRL3_uc001fqz.3_Missense_Mutation_p.D91N|FCRL3_uc009wsn.2_RNA|FCRL3_uc009wso.2_RNA|FCRL3_uc001fra.2_5'Flank|FCRL3_uc001frc.1_Missense_Mutation_p.D91N	NM_052939	NP_443171	Q96P31	FCRL3_HUMAN	Fc receptor-like 3 precursor	91	Ig-like C2-type 1.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(1)	4	all_hematologic(112;0.0378)																	---	---	---	---
TAGLN2	8407	broad.mit.edu	37	1	159888742	159888742	+	Intron	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:159888742A>G	uc001fum.1	-						CCDC19_uc001ful.2_Intron|TAGLN2_uc001fun.1_Intron|TAGLN2_uc001fuo.1_3'UTR	NM_003564	NP_003555			transgelin 2						muscle organ development	nuclear membrane|plasma membrane	protein binding				0	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.111)															---	---	---	---
GPATCH2	55105	broad.mit.edu	37	1	217793304	217793304	+	Silent	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:217793304G>A	uc001hlf.1	-	2	690	c.594C>T	c.(592-594)GCC>GCT	p.A198A	GPATCH2_uc001hlg.3_Silent_p.A198A	NM_018040	NP_060510	Q9NW75	GPTC2_HUMAN	G patch domain containing 2	198						intracellular	nucleic acid binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0397)|all cancers(67;0.0744)|GBM - Glioblastoma multiforme(131;0.0872)														---	---	---	---
ZP4	57829	broad.mit.edu	37	1	238049070	238049070	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:238049070A>C	uc001hym.2	-	7	956	c.956T>G	c.(955-957)CTT>CGT	p.L319R	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	319	ZP.|Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)															---	---	---	---
OR2L8	391190	broad.mit.edu	37	1	248113081	248113081	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:248113081T>C	uc001idt.1	+	1	922	c.922T>C	c.(922-924)TGC>CGC	p.C308R	OR2L13_uc001ids.2_Intron	NM_001001963	NP_001001963	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L,	308	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)															---	---	---	---
ZNF672	79894	broad.mit.edu	37	1	249142475	249142475	+	Silent	SNP	G	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:249142475G>T	uc001iex.2	+	4	1697	c.1002G>T	c.(1000-1002)ACG>ACT	p.T334T		NM_024836	NP_079112	Q499Z4	ZN672_HUMAN	zinc finger protein 672	334					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)															---	---	---	---
IL1R2	7850	broad.mit.edu	37	2	102625053	102625053	+	Missense_Mutation	SNP	G	A	A	rs148522700		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:102625053G>A	uc002tbm.2	+	2	245	c.16G>A	c.(16-18)GTG>ATG	p.V6M	IL1R2_uc002tbn.2_Missense_Mutation_p.V6M|IL1R2_uc002tbo.1_Missense_Mutation_p.V6M	NM_004633	NP_004624	P27930	IL1R2_HUMAN	interleukin 1 receptor, type II precursor	6					immune response	integral to membrane|plasma membrane	interleukin-1, Type II, blocking receptor activity			ovary(1)|breast(1)	2					Anakinra(DB00026)													---	---	---	---
EDAR	10913	broad.mit.edu	37	2	109513596	109513596	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:109513596T>G	uc002teq.3	-	12	1545	c.1114A>C	c.(1114-1116)AAA>CAA	p.K372Q	EDAR_uc010fjn.2_Missense_Mutation_p.K404Q|EDAR_uc010yws.1_Missense_Mutation_p.K404Q	NM_022336	NP_071731	Q9UNE0	EDAR_HUMAN	ectodysplasin A receptor precursor	372	Death.|Cytoplasmic (Potential).				apoptosis|cell differentiation	integral to membrane	protein binding|transmembrane receptor activity			skin(1)	1																		---	---	---	---
DPP10	57628	broad.mit.edu	37	2	115200414	115200414	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:115200414A>G	uc002tla.1	+	1	516	c.59A>G	c.(58-60)AAG>AGG	p.K20R		NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	20	Mediates effects on KCND2.|Cytoplasmic (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10																		---	---	---	---
CCDC93	54520	broad.mit.edu	37	2	118698836	118698836	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:118698836T>C	uc002tlj.2	-	19	1577	c.1451A>G	c.(1450-1452)AAG>AGG	p.K484R	CCDC93_uc010fld.1_Missense_Mutation_p.K484R	NM_019044	NP_061917	Q567U6	CCD93_HUMAN	coiled-coil domain containing 93	484										large_intestine(1)|ovary(1)	2																		---	---	---	---
MGAT5	4249	broad.mit.edu	37	2	135206285	135206285	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:135206285A>C	uc002ttv.1	+	16	2238	c.2093A>C	c.(2092-2094)AAG>ACG	p.K698T	LOC151162_uc002ttw.3_5'Flank	NM_002410	NP_002401	Q09328	MGT5A_HUMAN	N-acetylglucosaminyltransferase V	698	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity			ovary(2)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.0964)														---	---	---	---
THSD7B	80731	broad.mit.edu	37	2	138208477	138208477	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:138208477A>G	uc002tva.1	+	14	2929	c.2929A>G	c.(2929-2931)AGT>GGT	p.S977G	THSD7B_uc010zbj.1_Intron	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)														---	---	---	---
LRP1B	53353	broad.mit.edu	37	2	141625218	141625218	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:141625218T>G	uc002tvj.1	-	27	5492	c.4520A>C	c.(4519-4521)CAG>CCG	p.Q1507P	LRP1B_uc010fnl.1_Missense_Mutation_p.Q689P	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1507	Extracellular (Potential).|LDL-receptor class B 13.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)											TSP Lung(27;0.18)			---	---	---	---
GCG	2641	broad.mit.edu	37	2	163000597	163000597	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:163000597A>G	uc002ucc.2	-	5	575	c.476T>C	c.(475-477)CTT>CCT	p.L159P		NM_002054	NP_002045	P01275	GLUC_HUMAN	glucagon preproprotein	159					cell proliferation|cellular response to glucagon stimulus|energy reserve metabolic process|feeding behavior|regulation of insulin secretion	plasma membrane|soluble fraction	hormone activity				0					Exenatide(DB01276)|Phentolamine(DB00692)													---	---	---	---
SCN2A	6326	broad.mit.edu	37	2	166165773	166165773	+	Intron	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:166165773A>C	uc002udc.2	+						SCN2A_uc002udd.2_Intron|SCN2A_uc002ude.2_Intron	NM_001040142	NP_001035232			sodium channel, voltage-gated, type II, alpha						myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)													---	---	---	---
CSRNP3	80034	broad.mit.edu	37	2	166535430	166535430	+	Missense_Mutation	SNP	G	A	A	rs141222366		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:166535430G>A	uc002udf.2	+	7	1301	c.925G>A	c.(925-927)GTA>ATA	p.V309I	CSRNP3_uc002udg.2_Missense_Mutation_p.V309I	NM_024969	NP_079245	Q8WYN3	CSRN3_HUMAN	cysteine-serine-rich nuclear protein 3	309					apoptosis|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|large_intestine(1)|skin(1)	5																		---	---	---	---
XIRP2	129446	broad.mit.edu	37	2	168100111	168100111	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:168100111G>A	uc002udx.2	+	8	2227	c.2209G>A	c.(2209-2211)GAA>AAA	p.E737K	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.E562K|XIRP2_uc010fpq.2_Missense_Mutation_p.E515K|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	562	Xin 6.				actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14																		---	---	---	---
TTN	7273	broad.mit.edu	37	2	179425966	179425966	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179425966C>T	uc010zfg.1	-	275	77413	c.77189G>A	c.(77188-77190)CGG>CAG	p.R25730Q	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R19425Q|TTN_uc010zfi.1_Missense_Mutation_p.R19358Q|TTN_uc010zfj.1_Missense_Mutation_p.R19233Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	26657							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179445318	179445318	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179445318A>C	uc010zfg.1	-	266	59308	c.59084T>G	c.(59083-59085)CTT>CGT	p.L19695R	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.L13390R|TTN_uc010zfi.1_Missense_Mutation_p.L13323R|TTN_uc010zfj.1_Missense_Mutation_p.L13198R|uc002umv.1_3'UTR	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	20622							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179452255	179452255	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179452255C>T	uc010zfg.1	-	255	56301	c.56077G>A	c.(56077-56079)GTC>ATC	p.V18693I	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V12388I|TTN_uc010zfi.1_Missense_Mutation_p.V12321I|TTN_uc010zfj.1_Missense_Mutation_p.V12196I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	19620							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179458569	179458569	+	Silent	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179458569T>C	uc010zfg.1	-	247	50978	c.50754A>G	c.(50752-50754)CCA>CCG	p.P16918P	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.P10613P|TTN_uc010zfi.1_Silent_p.P10546P|TTN_uc010zfj.1_Silent_p.P10421P	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17845							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
PLCL1	5334	broad.mit.edu	37	2	198950584	198950584	+	Silent	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:198950584T>C	uc010fsp.2	+	2	2634	c.2343T>C	c.(2341-2343)ACT>ACC	p.T781T	PLCL1_uc002uuv.3_Silent_p.T702T	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	781	C2.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)													---	---	---	---
IKZF2	22807	broad.mit.edu	37	2	213878645	213878645	+	Silent	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:213878645T>C	uc002vem.2	-	7	895	c.726A>G	c.(724-726)GAA>GAG	p.E242E	IKZF2_uc010fuu.2_Silent_p.E97E|IKZF2_uc002vej.2_Silent_p.E189E|IKZF2_uc002vek.2_RNA|IKZF2_uc010fuv.2_Intron|IKZF2_uc002vel.2_Silent_p.E163E|IKZF2_uc010fuw.2_Silent_p.E16E|IKZF2_uc010fux.2_Silent_p.E16E|IKZF2_uc010fuy.2_Silent_p.E170E|IKZF2_uc002ven.2_Silent_p.E216E|IKZF2_uc002vei.2_Silent_p.E20E	NM_016260	NP_057344	Q9UKS7	IKZF2_HUMAN	helios isoform 1	242					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)														---	---	---	---
OBSL1	23363	broad.mit.edu	37	2	220424065	220424065	+	Silent	SNP	C	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:220424065C>A	uc010fwk.2	-	9	3165	c.3108G>T	c.(3106-3108)GTG>GTT	p.V1036V	OBSL1_uc002vmh.1_Silent_p.V27V|OBSL1_uc010zli.1_Silent_p.V27V|OBSL1_uc010fwl.1_Silent_p.V511V	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	1036	Ig-like 8.				cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)														---	---	---	---
C3orf20	84077	broad.mit.edu	37	3	14770025	14770025	+	Silent	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:14770025C>T	uc003byy.2	+	12	2174	c.1770C>T	c.(1768-1770)CCC>CCT	p.P590P	C3orf20_uc003byz.2_Silent_p.P468P|C3orf20_uc003bza.2_Silent_p.P468P|C3orf20_uc003bzb.1_Silent_p.P91P	NM_032137	NP_115513	Q8ND61	CC020_HUMAN	hypothetical protein LOC84077	590						cytoplasm|integral to membrane				ovary(3)|skin(1)	4																		---	---	---	---
UBA7	7318	broad.mit.edu	37	3	49850964	49850964	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49850964C>T	uc003cxr.2	-	2	344	c.173G>A	c.(172-174)AGC>AAC	p.S58N		NM_003335	NP_003326	P41226	UBA7_HUMAN	ubiquitin-like modifier activating enzyme 7	58	2 approximate repeats.|1-1.				ISG15-protein conjugation|negative regulation of type I interferon production	cytosol	ATP binding|ISG15 activating enzyme activity|ligase activity			ovary(1)|pancreas(1)	2				BRCA - Breast invasive adenocarcinoma(193;3.58e-06)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)														---	---	---	---
CACNA2D2	9254	broad.mit.edu	37	3	50416351	50416351	+	Missense_Mutation	SNP	T	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:50416351T>A	uc003daq.2	-	13	1372	c.1334A>T	c.(1333-1335)AAC>ATC	p.N445I	CACNA2D2_uc003dap.2_Missense_Mutation_p.N445I	NM_006030	NP_006021	Q9NY47	CA2D2_HUMAN	calcium channel, voltage-dependent, alpha	445	VWFA.|Extracellular (Potential).				energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000365)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)	Gabapentin(DB00996)													---	---	---	---
LRTM1	57408	broad.mit.edu	37	3	54958865	54958865	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:54958865A>C	uc003dhl.2	-	2	519	c.385T>G	c.(385-387)TTG>GTG	p.L129V	CACNA2D3_uc003dhf.2_Intron|CACNA2D3_uc003dhg.1_Intron|CACNA2D3_uc003dhh.1_Intron	NM_020678	NP_065729	Q9HBL6	LRTM1_HUMAN	leucine-rich repeats and transmembrane domains 1	129	LRR 4.|Extracellular (Potential).					integral to membrane					0				KIRC - Kidney renal clear cell carcinoma(284;0.00975)|Kidney(284;0.0112)|OV - Ovarian serous cystadenocarcinoma(275;0.0502)														---	---	---	---
ERC2	26059	broad.mit.edu	37	3	56183149	56183149	+	Silent	SNP	G	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:56183149G>T	uc003dhr.1	-	5	1417	c.1161C>A	c.(1159-1161)ATC>ATA	p.I387I		NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	387	Potential.					cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)														---	---	---	---
HTR1F	3355	broad.mit.edu	37	3	88040704	88040704	+	Silent	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:88040704A>C	uc003dqr.2	+	2	963	c.805A>C	c.(805-807)AGG>CGG	p.R269R		NM_000866	NP_000857	P30939	5HT1F_HUMAN	5-hydroxytryptamine (serotonin) receptor 1F	269	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	serotonin binding|serotonin receptor activity			ovary(3)	3	all_cancers(8;0.147)	Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00664)	Eletriptan(DB00216)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Zolmitriptan(DB00315)													---	---	---	---
ABI3BP	25890	broad.mit.edu	37	3	100595361	100595361	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:100595361T>C	uc003dun.2	-	7	846	c.761A>G	c.(760-762)AAG>AGG	p.K254R	ABI3BP_uc003duo.2_Missense_Mutation_p.K247R|ABI3BP_uc003dup.3_Missense_Mutation_p.K247R	NM_015429	NP_056244	Q7Z7G0	TARSH_HUMAN	ABI gene family, member 3 (NESH) binding protein	254						extracellular space				ovary(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)	4																		---	---	---	---
GK5	256356	broad.mit.edu	37	3	141900416	141900416	+	Intron	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:141900416A>C	uc003euq.1	-						GK5_uc003eup.1_Intron|GK5_uc010hus.1_Intron	NM_001039547	NP_001034636			glycerol kinase 5 (putative)						glycerol metabolic process		ATP binding|glycerol kinase activity				0																		---	---	---	---
XRN1	54464	broad.mit.edu	37	3	142048335	142048335	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:142048335G>A	uc003eus.2	-	37	4409	c.4342C>T	c.(4342-4344)CGA>TGA	p.R1448*	XRN1_uc010huu.2_Nonsense_Mutation_p.R915*|XRN1_uc003eut.2_Nonsense_Mutation_p.R1448*|XRN1_uc003euu.2_Nonsense_Mutation_p.R1449*	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a	1448					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3																		---	---	---	---
PLOD2	5352	broad.mit.edu	37	3	145803056	145803056	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:145803056A>G	uc003evs.1	-	11	1638	c.1132T>C	c.(1132-1134)TTT>CTT	p.F378L	PLOD2_uc003evq.1_Missense_Mutation_p.F38L|PLOD2_uc011bnm.1_Missense_Mutation_p.F323L|PLOD2_uc003evr.1_Missense_Mutation_p.F378L	NM_000935	NP_000926	O00469	PLOD2_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	378					protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2					Vitamin C(DB00126)													---	---	---	---
GPR87	53836	broad.mit.edu	37	3	151012123	151012123	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:151012123G>A	uc003eyt.2	-	3	1272	c.911C>T	c.(910-912)GCG>GTG	p.A304V	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron	NM_023915	NP_076404	Q9BY21	GPR87_HUMAN	G protein-coupled receptor 87	304	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			large_intestine(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)															---	---	---	---
MED12L	116931	broad.mit.edu	37	3	151101934	151101934	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:151101934C>A	uc003eyp.2	+	33	4787	c.4749C>A	c.(4747-4749)GAC>GAA	p.D1583E	MED12L_uc011bnz.1_Missense_Mutation_p.D1443E|P2RY12_uc011boa.1_Intron|P2RY12_uc003eyx.1_Intron|MED12L_uc003eyy.1_Missense_Mutation_p.D746E	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	1583					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)															---	---	---	---
SGEF	26084	broad.mit.edu	37	3	153847381	153847381	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:153847381A>G	uc011bog.1	+	4	1353	c.1142A>G	c.(1141-1143)CAA>CGA	p.Q381R	SGEF_uc011boh.1_Missense_Mutation_p.Q381R	NM_015595	NP_056410	Q96DR7	ARHGQ_HUMAN	Src homology 3 domain-containing guanine	381					regulation of Rho protein signal transduction	intracellular|ruffle	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)															---	---	---	---
PIK3CA	5290	broad.mit.edu	37	3	178928079	178928079	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:178928079G>A	uc003fjk.2	+	8	1514	c.1357G>A	c.(1357-1359)GAA>AAA	p.E453K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	453	C2 PI3K-type.		E -> Q (in cancer; shows an increase in lipid kinase activity; may disrupt the interaction of the C2 PI3K-type domain with the iSH2 region of the p85 regulatory subunit).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E453K(5)|p.E453Q(1)|p.E453A(1)|p.P449_L455del(1)|p.G451_L456>V(1)|p.E453del(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)				57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			---	---	---	---
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	A	A	rs104886003		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			---	---	---	---
CCDC39	339829	broad.mit.edu	37	3	180372680	180372680	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:180372680T>C	uc010hxe.2	-	7	915	c.800A>G	c.(799-801)AAG>AGG	p.K267R	CCDC39_uc003fkn.2_RNA	NM_181426	NP_852091	Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	267	Potential.				axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				ovary(4)	4	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)															---	---	---	---
CCDC39	339829	broad.mit.edu	37	3	180377341	180377341	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:180377341A>C	uc010hxe.2	-	6	752	c.637T>G	c.(637-639)TTT>GTT	p.F213V	CCDC39_uc003fkn.2_RNA	NM_181426	NP_852091	Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	213	Potential.				axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				ovary(4)	4	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)															---	---	---	---
ETV5	2119	broad.mit.edu	37	3	185798929	185798929	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:185798929G>A	uc003fpz.2	-	6	515	c.268C>T	c.(268-270)CGG>TGG	p.R90W	ETV5_uc003fpy.2_Missense_Mutation_p.R132W	NM_004454	NP_004445	P41161	ETV5_HUMAN	ets variant gene 5 (ets-related molecule)	90					cellular response to oxidative stress	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)|skin(2)|breast(1)	5	all_cancers(143;4.06e-12)|Ovarian(172;0.0386)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.62e-24)					T	TMPRSS2|SCL45A3	Prostate 								---	---	---	---
ZDHHC19	131540	broad.mit.edu	37	3	195938172	195938172	+	Silent	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:195938172C>T	uc003fwc.2	-	1	129	c.15G>A	c.(13-15)ACG>ACA	p.T5T	ZDHHC19_uc010hzz.2_RNA|ZDHHC19_uc010iaa.2_RNA|ZDHHC19_uc010iab.2_RNA	NM_001039617	NP_001034706	Q8WVZ1	ZDH19_HUMAN	zinc finger, DHHC domain containing 19	5						integral to membrane	acyltransferase activity|zinc ion binding			ovary(3)	3	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.89e-25)|all cancers(36;1.46e-23)|OV - Ovarian serous cystadenocarcinoma(49;2.1e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0022)														---	---	---	---
EVC2	132884	broad.mit.edu	37	4	5620291	5620291	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:5620291G>A	uc003gij.2	-	15	2674	c.2620C>T	c.(2620-2622)CGA>TGA	p.R874*	EVC2_uc011bwb.1_Nonsense_Mutation_p.R314*|EVC2_uc003gik.2_Nonsense_Mutation_p.R794*	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	874						integral to membrane				large_intestine(3)|ovary(2)	5																		---	---	---	---
DRD5	1816	broad.mit.edu	37	4	9784832	9784832	+	Silent	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:9784832C>T	uc003gmb.3	+	1	1575	c.1179C>T	c.(1177-1179)CTC>CTT	p.L393L		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	393	Cytoplasmic (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)													---	---	---	---
SLIT2	9353	broad.mit.edu	37	4	20270427	20270427	+	Intron	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:20270427C>T	uc003gpr.1	+						SLIT2_uc003gps.1_Intron	NM_004787	NP_004778			slit homolog 2 precursor						apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11																		---	---	---	---
GBA3	57733	broad.mit.edu	37	4	22820403	22820403	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:22820403T>G	uc003gqp.3	+	5	1358	c.1267T>G	c.(1267-1269)TTT>GTT	p.F423V	GBA3_uc010iep.2_Missense_Mutation_p.F116V|GBA3_uc011bxo.1_Missense_Mutation_p.F424V	NM_020973	NP_066024	Q9H227	GBA3_HUMAN	cytosolic beta-glucosidase isoform a	423					glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity				0																		---	---	---	---
PPARGC1A	10891	broad.mit.edu	37	4	23814390	23814390	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:23814390T>C	uc003gqs.2	-	10	2119	c.1999A>G	c.(1999-2001)AGG>GGG	p.R667G	PPARGC1A_uc003gqt.2_RNA	NM_013261	NP_037393	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor	667					androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			ovary(2)|lung(2)|kidney(2)|skin(2)	8		Breast(46;0.0503)																---	---	---	---
PTPN13	5783	broad.mit.edu	37	4	87724935	87724935	+	Silent	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:87724935G>A	uc003hpz.2	+	43	7059	c.6579G>A	c.(6577-6579)ACG>ACA	p.T2193T	PTPN13_uc003hpy.2_Silent_p.T2198T|PTPN13_uc003hqa.2_Silent_p.T2174T|PTPN13_uc003hqb.2_Silent_p.T2002T|PTPN13_uc003hqc.1_Silent_p.T559T	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	2193						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)														---	---	---	---
DDIT4L	115265	broad.mit.edu	37	4	101109157	101109157	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:101109157T>C	uc003hvq.2	-	3	462	c.259A>G	c.(259-261)AGA>GGA	p.R87G		NM_145244	NP_660287	Q96D03	DDT4L_HUMAN	DNA-damage-inducible transcript 4-like	87					negative regulation of signal transduction	cytoplasm				ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;5.75e-09)														---	---	---	---
ANK2	287	broad.mit.edu	37	4	114278657	114278657	+	Silent	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:114278657T>C	uc003ibe.3	+	38	8983	c.8883T>C	c.(8881-8883)TCT>TCC	p.S2961S	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Silent_p.S263S|ANK2_uc011cgb.1_Silent_p.S2976S	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	2928					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)														---	---	---	---
NDST4	64579	broad.mit.edu	37	4	115997948	115997948	+	Missense_Mutation	SNP	A	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:115997948A>T	uc003ibu.2	-	2	924	c.245T>A	c.(244-246)CTC>CAC	p.L82H	NDST4_uc010imw.2_Intron	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	82	Lumenal (Potential).|Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)														---	---	---	---
FAT4	79633	broad.mit.edu	37	4	126371322	126371322	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:126371322T>G	uc003ifj.3	+	9	9151	c.9151T>G	c.(9151-9153)TTG>GTG	p.L3051V	FAT4_uc011cgp.1_Missense_Mutation_p.L1349V|FAT4_uc003ifi.1_Missense_Mutation_p.L529V	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3051	Extracellular (Potential).|Cadherin 29.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18																		---	---	---	---
INTU	27152	broad.mit.edu	37	4	128629739	128629739	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:128629739A>C	uc003ifk.1	+	13	2355	c.2285A>C	c.(2284-2286)AAG>ACG	p.K762T	INTU_uc011cgq.1_RNA	NM_015693	NP_056508	Q9ULD6	PDZD6_HUMAN	PDZ domain containing 6	762										ovary(1)	1																		---	---	---	---
DCLK2	166614	broad.mit.edu	37	4	151023936	151023936	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:151023936A>G	uc003ilm.3	+	2	828	c.728A>G	c.(727-729)AAG>AGG	p.K243R	DCLK2_uc003iln.3_Missense_Mutation_p.K243R|DCLK2_uc003ilo.3_Missense_Mutation_p.K243R|DCLK2_uc003ilp.3_RNA	NM_001040260	NP_001035350	Q8N568	DCLK2_HUMAN	doublecortin-like kinase 2 isoform a	243	Doublecortin 2.				intracellular signal transduction	cytoplasm|cytoskeleton	ATP binding|protein serine/threonine kinase activity			ovary(3)	3	all_hematologic(180;0.151)																	---	---	---	---
RBM46	166863	broad.mit.edu	37	4	155720526	155720526	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:155720526A>C	uc003ioo.2	+	4	1385	c.1212A>C	c.(1210-1212)AAA>AAC	p.K404N	RBM46_uc011cim.1_Missense_Mutation_p.K404N|RBM46_uc003iop.1_Missense_Mutation_p.K404N	NM_144979	NP_659416	Q8TBY0	RBM46_HUMAN	RNA binding motif protein 46	404							nucleotide binding|RNA binding			central_nervous_system(1)|skin(1)	2	all_hematologic(180;0.24)	Renal(120;0.0854)																---	---	---	---
GUCY1A3	2982	broad.mit.edu	37	4	156634503	156634503	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:156634503A>C	uc003iov.2	+	8	1876	c.1340A>C	c.(1339-1341)AAG>ACG	p.K447T	GUCY1A3_uc010iqc.2_Missense_Mutation_p.K447T|GUCY1A3_uc003iow.2_Missense_Mutation_p.K447T|GUCY1A3_uc010iqd.2_Missense_Mutation_p.K446T|GUCY1A3_uc003iox.2_Missense_Mutation_p.K447T|GUCY1A3_uc003ioz.2_Missense_Mutation_p.K212T|GUCY1A3_uc003ioy.2_Missense_Mutation_p.K447T|GUCY1A3_uc010iqe.2_Missense_Mutation_p.K212T|GUCY1A3_uc003ipa.2_Intron|GUCY1A3_uc003ipb.2_Missense_Mutation_p.K447T	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	447					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)														---	---	---	---
TDO2	6999	broad.mit.edu	37	4	156831278	156831278	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:156831278G>T	uc003ipf.1	+	6	597	c.533G>T	c.(532-534)AGA>ATA	p.R178I		NM_005651	NP_005642	P48775	T23O_HUMAN	tryptophan 2,3-dioxygenase	178					tryptophan catabolic process to kynurenine	cytosol	tryptophan 2,3-dioxygenase activity				0	all_hematologic(180;0.24)	Renal(120;0.0854)		KIRC - Kidney renal clear cell carcinoma(143;0.0455)|Kidney(143;0.0568)|COAD - Colon adenocarcinoma(41;0.141)	L-Tryptophan(DB00150)													---	---	---	---
FNIP2	57600	broad.mit.edu	37	4	159790449	159790449	+	Silent	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:159790449T>C	uc003iqe.3	+	13	2844	c.2661T>C	c.(2659-2661)ATT>ATC	p.I887I		NM_020840	NP_065891	Q9P278	FNIP2_HUMAN	folliculin interacting protein 2	887	Interaction with PRKAA1.				DNA damage response, signal transduction resulting in induction of apoptosis|protein phosphorylation|regulation of protein phosphorylation	cytoplasm	protein binding				0	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.00936)														---	---	---	---
CCDC111	201973	broad.mit.edu	37	4	185593358	185593358	+	Silent	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:185593358T>G	uc003iwk.2	+	7	1021	c.588T>G	c.(586-588)GCT>GCG	p.A196A	CCDC111_uc010isd.1_RNA|CCDC111_uc003iwj.2_Silent_p.A196A|CCDC111_uc003iwl.2_Silent_p.A196A|CCDC111_uc003iwm.2_Silent_p.A67A|CCDC111_uc003iwn.2_Silent_p.A21A	NM_152683	NP_689896	Q96LW4	CC111_HUMAN	coiled-coil domain containing 111	196					DNA replication, synthesis of RNA primer		DNA primase activity			central_nervous_system(1)	1		all_lung(41;9.65e-12)|Lung NSC(41;1.64e-11)|Colorectal(36;0.00531)|Hepatocellular(41;0.00932)|Renal(120;0.0246)|Prostate(90;0.0283)|all_hematologic(60;0.0749)|all_neural(102;0.131)		all cancers(43;5.84e-27)|Epithelial(43;2.2e-23)|OV - Ovarian serous cystadenocarcinoma(60;4.28e-11)|STAD - Stomach adenocarcinoma(60;2.66e-05)|GBM - Glioblastoma multiforme(59;3.03e-05)|Colorectal(24;7.57e-05)|BRCA - Breast invasive adenocarcinoma(30;0.000249)|COAD - Colon adenocarcinoma(29;0.000502)|LUSC - Lung squamous cell carcinoma(40;0.00995)|READ - Rectum adenocarcinoma(43;0.173)														---	---	---	---
CCDC110	256309	broad.mit.edu	37	4	186379713	186379713	+	Silent	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:186379713A>G	uc003ixu.3	-	6	2104	c.2028T>C	c.(2026-2028)TTT>TTC	p.F676F	CCDC110_uc003ixv.3_Silent_p.F639F|CCDC110_uc011ckt.1_Silent_p.F676F	NM_152775	NP_689988	Q8TBZ0	CC110_HUMAN	coiled-coil domain containing 110 isoform a	676	Potential.					nucleus				central_nervous_system(1)	1		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;7.86e-05)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|Colorectal(36;0.0381)|all_hematologic(60;0.0749)		OV - Ovarian serous cystadenocarcinoma(60;1.13e-10)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.00014)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00921)|COAD - Colon adenocarcinoma(29;0.0105)|READ - Rectum adenocarcinoma(43;0.164)														---	---	---	---
ZFR	51663	broad.mit.edu	37	5	32400164	32400164	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:32400164A>G	uc003jhr.1	-	9	1741	c.1661T>C	c.(1660-1662)CTT>CCT	p.L554P		NM_016107	NP_057191	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	554					multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding				0				STAD - Stomach adenocarcinoma(35;0.19)														---	---	---	---
SLC45A2	51151	broad.mit.edu	37	5	33982444	33982444	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:33982444A>C	uc003jid.2	-	2	551	c.459T>G	c.(457-459)GAT>GAG	p.D153E	SLC45A2_uc003jie.2_Missense_Mutation_p.D153E|SLC45A2_uc003jif.3_Missense_Mutation_p.D153E|SLC45A2_uc011coe.1_Missense_Mutation_p.D153E	NM_016180	NP_057264	Q9UMX9	S45A2_HUMAN	membrane-associated transporter protein isoform	153	Helical; Name=4; (Potential).				melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3																		---	---	---	---
UGT3A1	133688	broad.mit.edu	37	5	35991320	35991320	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:35991320A>C	uc003jjv.1	-	1	180	c.23T>G	c.(22-24)CTT>CGT	p.L8R	UGT3A1_uc003jjw.1_RNA|UGT3A1_uc011coq.1_Missense_Mutation_p.L8R|UGT3A1_uc011cor.1_Missense_Mutation_p.L8R|UGT3A1_uc003jjy.1_Intron	NM_152404	NP_689617	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	8						integral to membrane	glucuronosyltransferase activity			ovary(2)|central_nervous_system(1)	3	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)															---	---	---	---
GHR	2690	broad.mit.edu	37	5	42718874	42718874	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:42718874A>G	uc003jmt.2	+	10	1308	c.1265A>G	c.(1264-1266)GAT>GGT	p.D422G	GHR_uc011cpq.1_Missense_Mutation_p.D235G	NM_000163	NP_000154	P10912	GHR_HUMAN	growth hormone receptor precursor	422	Cytoplasmic (Potential).				2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			lung(4)|kidney(1)|skin(1)	6		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)													---	---	---	---
DDX4	54514	broad.mit.edu	37	5	55088488	55088488	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:55088488A>C	uc003jqg.3	+	17	1396	c.1322A>C	c.(1321-1323)AAA>ACA	p.K441T	DDX4_uc010ivz.2_Missense_Mutation_p.K421T|DDX4_uc003jqh.3_Missense_Mutation_p.K407T|DDX4_uc003jqj.2_Missense_Mutation_p.K292T	NM_001136034	NP_001129506	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform	441	Helicase ATP-binding.				multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|skin(1)	2		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)																---	---	---	---
GPR98	84059	broad.mit.edu	37	5	89990213	89990213	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:89990213T>G	uc003kju.2	+	33	7736	c.7640T>G	c.(7639-7641)CTC>CGC	p.L2547R	GPR98_uc003kjt.2_Missense_Mutation_p.L253R|GPR98_uc003kjv.2_Missense_Mutation_p.L147R	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	2547	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)														---	---	---	---
PAM	5066	broad.mit.edu	37	5	102295728	102295728	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:102295728A>G	uc003knw.2	+	12	1428	c.1055A>G	c.(1054-1056)AAG>AGG	p.K352R	PAM_uc003kns.2_Missense_Mutation_p.K352R|PAM_uc003knt.2_Missense_Mutation_p.K352R|PAM_uc003knu.2_Missense_Mutation_p.K352R|PAM_uc003knv.2_Missense_Mutation_p.K352R|PAM_uc011cuz.1_Missense_Mutation_p.K255R|PAM_uc003knx.1_Missense_Mutation_p.K44R	NM_000919	NP_000910	P19021	AMD_HUMAN	peptidylglycine alpha-amidating monooxygenase	352	Peptidylglycine alpha-hydroxylating monooxygenase (By similarity).|Intragranular (Potential).				peptide metabolic process|protein modification process	extracellular region|integral to membrane|stored secretory granule	L-ascorbic acid binding|peptidylamidoglycolate lyase activity|peptidylglycine monooxygenase activity|protein binding				0		all_cancers(142;3.12e-07)|all_epithelial(76;3.48e-10)|Prostate(80;0.00914)|Lung NSC(167;0.0213)|Ovarian(225;0.024)|Colorectal(57;0.0251)|all_lung(232;0.0284)		Epithelial(69;1.1e-13)|COAD - Colon adenocarcinoma(37;0.0127)	Vitamin C(DB00126)													---	---	---	---
FBN2	2201	broad.mit.edu	37	5	127855063	127855063	+	Splice_Site	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:127855063T>G	uc003kuu.2	-	5	972	c.533_splice	c.e5-1	p.P178_splice	FBN2_uc003kuv.2_Splice_Site_p.P145_splice|FBN2_uc003kuw.3_Splice_Site_p.P178_splice|FBN2_uc003kux.1_Splice_Site_p.P178_splice	NM_001999	NP_001990			fibrillin 2 precursor						bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)														---	---	---	---
MYOT	9499	broad.mit.edu	37	5	137222974	137222974	+	Missense_Mutation	SNP	T	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:137222974T>A	uc011cye.1	+	10	1414	c.1397T>A	c.(1396-1398)CTT>CAT	p.L466H	PKD2L2_uc010jep.1_5'Flank|PKD2L2_uc003lbw.1_5'Flank|PKD2L2_uc003lbx.2_5'Flank|PKD2L2_uc003lby.2_5'Flank|MYOT_uc003lbv.2_Missense_Mutation_p.L466H|MYOT_uc011cyg.1_Missense_Mutation_p.L282H|MYOT_uc011cyh.1_Missense_Mutation_p.L351H	NM_001135940	NP_001129412	Q9UBF9	MYOTI_HUMAN	myotilin isoform b	466	Necessary for interaction with ACTA1.|Necessary for interaction with FLNC.				muscle contraction	actin cytoskeleton|sarcolemma|sarcomere	actin binding|structural constituent of muscle			large_intestine(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)															---	---	---	---
PCDHA10	56139	broad.mit.edu	37	5	140236926	140236926	+	Silent	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140236926G>A	uc003lhx.2	+	1	1293	c.1293G>A	c.(1291-1293)TCG>TCA	p.S431S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Silent_p.S431S|PCDHA10_uc011dad.1_Silent_p.S431S	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	431	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding	p.S431S(1)		ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHAC2	56134	broad.mit.edu	37	5	140347619	140347619	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140347619T>G	uc003lii.2	+	1	1508	c.1268T>G	c.(1267-1269)GTG>GGG	p.V423G	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lih.2_Intron|PCDHAC2_uc011dag.1_Missense_Mutation_p.V423G	NM_018899	NP_061722	Q9Y5I4	PCDC2_HUMAN	protocadherin alpha subfamily C, 2 isoform 1	423	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
SH3TC2	79628	broad.mit.edu	37	5	148389903	148389903	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:148389903A>G	uc003lpu.2	-	14	3409	c.3257T>C	c.(3256-3258)CTT>CCT	p.L1086P	SH3TC2_uc003lpp.1_RNA|SH3TC2_uc010jgw.2_Missense_Mutation_p.L730P|SH3TC2_uc003lps.2_RNA|SH3TC2_uc003lpt.2_Missense_Mutation_p.L633P|SH3TC2_uc010jgx.2_Missense_Mutation_p.L1079P	NM_024577	NP_078853	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	1086	TPR 5.						binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
FAT2	2196	broad.mit.edu	37	5	150908754	150908754	+	Silent	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:150908754A>G	uc003lue.3	-	14	10024	c.10011T>C	c.(10009-10011)GGT>GGC	p.G3337G	GM2A_uc011dcs.1_Intron|FAT2_uc003lud.3_Silent_p.G30G	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	3337	Cadherin 30.|Extracellular (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)															---	---	---	---
IL12B	3593	broad.mit.edu	37	5	158743698	158743698	+	Missense_Mutation	SNP	T	A	A	rs143277765		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:158743698T>A	uc003lxr.1	-	7	1024	c.982A>T	c.(982-984)AGT>TGT	p.S328C		NM_002187	NP_002178	P29460	IL12B_HUMAN	interleukin 12B precursor	328					cell cycle arrest|cell migration|defense response to Gram-negative bacterium|interferon-gamma biosynthetic process|natural killer cell activation|negative regulation of interleukin-10 production|negative regulation of interleukin-17 production|negative regulation of smooth muscle cell proliferation|positive regulation of activated T cell proliferation|positive regulation of activation of JAK2 kinase activity|positive regulation of cell adhesion|positive regulation of defense response to virus by host|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-17 production|positive regulation of memory T cell differentiation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of natural killer cell proliferation|positive regulation of NF-kappaB import into nucleus|positive regulation of NK T cell activation|positive regulation of NK T cell proliferation|positive regulation of osteoclast differentiation|positive regulation of smooth muscle cell apoptosis|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat4 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|regulation of tyrosine phosphorylation of Stat1 protein|response to UV-B|sexual reproduction|T-helper 1 type immune response|T-helper cell differentiation	interleukin-12 complex|interleukin-23 complex|membrane	cytokine activity|cytokine receptor activity|interleukin-12 receptor binding|protein heterodimerization activity				0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)													OREG0016989	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
WWC1	23286	broad.mit.edu	37	5	167824784	167824784	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:167824784A>C	uc003lzu.2	+	4	582	c.489A>C	c.(487-489)GAA>GAC	p.E163D	WWC1_uc003lzv.2_Missense_Mutation_p.E163D|WWC1_uc011den.1_Missense_Mutation_p.E163D	NM_015238	NP_056053	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1 isoform 3	163	Potential.				cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			ovary(2)|skin(2)|breast(1)	5	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)														---	---	---	---
FOXQ1	94234	broad.mit.edu	37	6	1313596	1313596	+	Silent	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:1313596C>T	uc003mtl.3	+	1	922	c.657C>T	c.(655-657)CGC>CGT	p.R219R		NM_033260	NP_150285	Q9C009	FOXQ1_HUMAN	forkhead box Q1	219					DNA fragmentation involved in apoptotic nuclear change|embryo development|hair follicle morphogenesis|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding				0	Ovarian(93;0.0733)	Breast(5;0.052)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.0954)|BRCA - Breast invasive adenocarcinoma(62;0.18)														---	---	---	---
IP6K3	117283	broad.mit.edu	37	6	33703132	33703132	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:33703132T>C	uc010jvf.2	-	3	658	c.122A>G	c.(121-123)AAG>AGG	p.K41R	IP6K3_uc003ofb.2_Missense_Mutation_p.K41R	NM_001142883	NP_001136355	Q96PC2	IP6K3_HUMAN	inositol hexakisphosphate kinase 3	41					inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|protein phosphorylation	cytoplasm	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol hexakisphosphate 6-kinase activity|inositol trisphosphate 3-kinase activity				0																		---	---	---	---
UBR2	23304	broad.mit.edu	37	6	42612227	42612227	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:42612227A>C	uc011dur.1	+	20	2237	c.2237A>C	c.(2236-2238)AAC>ACC	p.N746T	UBR2_uc011dus.1_Missense_Mutation_p.N391T|UBR2_uc003osh.2_RNA	NM_015255	NP_056070	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin	746					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			ovary(3)|pancreas(1)	4	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)															---	---	---	---
FILIP1	27145	broad.mit.edu	37	6	76072455	76072455	+	Intron	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:76072455T>G	uc003pia.2	-						FILIP1_uc003phy.1_Intron|FILIP1_uc003phz.2_Intron|FILIP1_uc010kbe.2_Intron	NM_015687	NP_056502			filamin A interacting protein 1											skin(3)|ovary(1)	4																		---	---	---	---
DOPEY1	23033	broad.mit.edu	37	6	83845580	83845580	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:83845580A>C	uc003pjs.1	+	20	3373	c.3113A>C	c.(3112-3114)AAT>ACT	p.N1038T	DOPEY1_uc011dyy.1_Missense_Mutation_p.N1029T|DOPEY1_uc010kbl.1_Missense_Mutation_p.N1029T|DOPEY1_uc003pjt.2_5'Flank	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	1038					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)														---	---	---	---
LAMA4	3910	broad.mit.edu	37	6	112471810	112471810	+	Silent	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:112471810A>G	uc003pvu.2	-	17	2385	c.2076T>C	c.(2074-2076)GCT>GCC	p.A692A	LAMA4_uc003pvv.2_Silent_p.A685A|LAMA4_uc003pvt.2_Silent_p.A685A	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	692	Domain II and I.|Potential.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)														---	---	---	---
C6orf170	221322	broad.mit.edu	37	6	121576500	121576500	+	Silent	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:121576500A>G	uc003pyo.1	-	17	2060	c.1992T>C	c.(1990-1992)TCT>TCC	p.S664S	C6orf170_uc003pyq.1_RNA|C6orf170_uc003pyp.1_Silent_p.S183S	NM_152730	NP_689943	Q96NH3	BROMI_HUMAN	hypothetical protein LOC221322	664					multicellular organismal development	cilium|cytoplasm	Rab GTPase activator activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(226;0.00521)														---	---	---	---
SERINC1	57515	broad.mit.edu	37	6	122779730	122779730	+	Silent	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:122779730A>G	uc003pyy.1	-	2	206	c.136T>C	c.(136-138)TTG>CTG	p.L46L		NM_020755	NP_065806	Q9NRX5	SERC1_HUMAN	serine incorporator 1	46	Helical; (Potential).				phosphatidylserine metabolic process|phospholipid biosynthetic process|positive regulation of transferase activity|sphingolipid metabolic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	L-serine transmembrane transporter activity|protein binding			ovary(1)	1				GBM - Glioblastoma multiforme(226;0.126)														---	---	---	---
SHPRH	257218	broad.mit.edu	37	6	146254276	146254276	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:146254276T>G	uc003qlf.2	-	14	3428	c.3029A>C	c.(3028-3030)AAG>ACG	p.K1010T	SHPRH_uc003qld.2_Missense_Mutation_p.K1019T|SHPRH_uc003qle.2_Missense_Mutation_p.K1019T|SHPRH_uc003qlg.1_Missense_Mutation_p.K566T|SHPRH_uc003qlh.2_5'UTR	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	1010					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)														---	---	---	---
VIP	7432	broad.mit.edu	37	6	153075433	153075433	+	Intron	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:153075433T>G	uc003qpe.2	+						VIP_uc003qpf.2_Intron|VIP_uc010kjd.2_Intron	NM_003381	NP_003372			vasoactive intestinal peptide isoform 1						body fluid secretion|G-protein coupled receptor protein signaling pathway|positive regulation of cell proliferation	extracellular region	neuropeptide hormone activity				0		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;4.5e-11)|BRCA - Breast invasive adenocarcinoma(81;0.144)														---	---	---	---
THSD7A	221981	broad.mit.edu	37	7	11581104	11581104	+	Silent	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:11581104G>A	uc003ssf.3	-	6	2016	c.1764C>T	c.(1762-1764)AAC>AAT	p.N588N		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	588	Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)											HNSCC(18;0.044)			---	---	---	---
AGR3	155465	broad.mit.edu	37	7	16900136	16900136	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:16900136C>T	uc003sts.2	-	7	512	c.439G>A	c.(439-441)GAT>AAT	p.D147N		NM_176813	NP_789783	Q8TD06	AGR3_HUMAN	breast cancer membrane protein 11 precursor	147						extracellular region					0	Lung NSC(10;0.0376)|all_lung(11;0.0721)|all_epithelial(12;0.202)			UCEC - Uterine corpus endometrioid carcinoma (126;0.184)														---	---	---	---
KBTBD2	25948	broad.mit.edu	37	7	32909212	32909212	+	Silent	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:32909212T>C	uc003tdb.2	-	4	2276	c.1617A>G	c.(1615-1617)CGA>CGG	p.R539R	AVL9_uc011kai.1_Intron	NM_015483	NP_056298	Q8IY47	KBTB2_HUMAN	kelch repeat and BTB (POZ) domain containing 2	539	Kelch 5.										0			GBM - Glioblastoma multiforme(11;0.0499)															---	---	---	---
FKBP9	11328	broad.mit.edu	37	7	33014900	33014900	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:33014900T>G	uc003tdh.2	+	3	655	c.474T>G	c.(472-474)AGT>AGG	p.S158R	AVL9_uc011kai.1_Intron|FKBP9_uc011kak.1_RNA|FKBP9_uc011kal.1_Missense_Mutation_p.S211R|FKBP9_uc003tdg.2_Missense_Mutation_p.S158R|FKBP9_uc010kwm.2_Missense_Mutation_p.S65R	NM_007270	NP_009201	O95302	FKBP9_HUMAN	FK506 binding protein 9 precursor	158					protein folding	endoplasmic reticulum|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			central_nervous_system(13)|ovary(1)	14			GBM - Glioblastoma multiforme(11;0.0156)															---	---	---	---
ABCB4	5244	broad.mit.edu	37	7	87076341	87076341	+	Intron	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:87076341A>C	uc003uiv.1	-						ABCB4_uc003uiw.1_Intron|ABCB4_uc003uix.1_Intron	NM_018849	NP_061337			ATP-binding cassette, subfamily B, member 4						cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)																	---	---	---	---
COL1A2	1278	broad.mit.edu	37	7	94041406	94041406	+	Silent	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:94041406C>T	uc003ung.1	+	24	1848	c.1377C>T	c.(1375-1377)ATC>ATT	p.I459I	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	459					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)										HNSCC(75;0.22)			---	---	---	---
DLX6	1750	broad.mit.edu	37	7	96639182	96639182	+	Silent	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:96639182C>T	uc003uom.2	+	4	621	c.621C>T	c.(619-621)AGC>AGT	p.S207S	DLX6AS_uc003uol.2_Intron|DLX6AS_uc010lfo.1_Intron	NM_005222	NP_005213	P56179	DLX6_HUMAN	distal-less homeobox 6	117					nervous system development|skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	all_cancers(62;9.56e-09)|all_epithelial(64;7.38e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0855)|Lung NSC(181;0.0858)																	---	---	---	---
ZNF789	285989	broad.mit.edu	37	7	99077375	99077375	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99077375T>C	uc003uqq.1	+	3	335	c.116T>C	c.(115-117)GTG>GCG	p.V39A	ZNF789_uc003uqp.2_Missense_Mutation_p.V39A|ZNF789_uc010lfw.1_5'UTR	NM_213603	NP_998768	Q5FWF6	ZN789_HUMAN	zinc finger protein 789 isoform 1	39	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)																	---	---	---	---
MUC17	140453	broad.mit.edu	37	7	100675453	100675453	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100675453A>C	uc003uxp.1	+	3	809	c.756A>C	c.(754-756)CAA>CAC	p.Q252H	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	252	Extracellular (Potential).|59 X approximate tandem repeats.|2.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)																	---	---	---	---
MUC17	140453	broad.mit.edu	37	7	100686766	100686766	+	Silent	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100686766T>G	uc003uxp.1	+	3	12122	c.12069T>G	c.(12067-12069)ACT>ACG	p.T4023T	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	4023	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)																	---	---	---	---
CTTNBP2	83992	broad.mit.edu	37	7	117432071	117432071	+	Silent	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:117432071A>G	uc003vjf.2	-	4	1271	c.1179T>C	c.(1177-1179)GAT>GAC	p.D393D		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	393	Pro-rich.									ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)														---	---	---	---
TSPAN12	23554	broad.mit.edu	37	7	120446622	120446622	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:120446622A>G	uc003vjk.2	-	7	967	c.593T>C	c.(592-594)CTC>CCC	p.L198P	TSPAN12_uc010lkj.2_Missense_Mutation_p.L71P	NM_012338	NP_036470	O95859	TSN12_HUMAN	transmembrane 4 superfamily member 12	198	Extracellular (Potential).				angiogenesis|cell surface receptor linked signaling pathway|regulation of angiogenesis|retina layer formation	integral to plasma membrane|membrane fraction					0	all_neural(327;0.117)																	---	---	---	---
IQUB	154865	broad.mit.edu	37	7	123119949	123119949	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:123119949A>G	uc003vkn.2	-	8	1887	c.1310T>C	c.(1309-1311)CTT>CCT	p.L437P	IQUB_uc003vko.2_Missense_Mutation_p.L437P|IQUB_uc010lkt.2_Intron|IQUB_uc003vkp.1_Missense_Mutation_p.L437P	NM_178827	NP_849149	Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	437										ovary(3)|large_intestine(1)	4																		---	---	---	---
BLK	640	broad.mit.edu	37	8	11421550	11421550	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:11421550A>G	uc003wty.2	+	13	2032	c.1451A>G	c.(1450-1452)GAG>GGG	p.E484G	BLK_uc003wtz.2_Missense_Mutation_p.E413G|BLK_uc003wua.2_Missense_Mutation_p.E320G	NM_001715	NP_001706	P51451	BLK_HUMAN	B lymphoid tyrosine kinase	484	Protein kinase.				intracellular protein kinase cascade|positive regulation of insulin secretion		ATP binding|non-membrane spanning protein tyrosine kinase activity			large_intestine(1)|stomach(1)|ovary(1)	3			STAD - Stomach adenocarcinoma(15;0.00391)	COAD - Colon adenocarcinoma(149;0.207)														---	---	---	---
DEFB134	613211	broad.mit.edu	37	8	11851601	11851601	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:11851601T>C	uc011kxn.1	-	2	89	c.89A>G	c.(88-90)AAG>AGG	p.K30R		NM_001033019	NP_001028191	Q4QY38	DB134_HUMAN	beta-defensin 134 precursor	30					defense response to bacterium	extracellular region					0			STAD - Stomach adenocarcinoma(15;0.033)	COAD - Colon adenocarcinoma(149;0.159)														---	---	---	---
MTUS1	57509	broad.mit.edu	37	8	17504590	17504590	+	Splice_Site	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:17504590T>G	uc003wxv.2	-	14	3976	c.3502_splice	c.e14-1	p.V1168_splice	MTUS1_uc003wxt.2_Splice_Site_p.V415_splice|MTUS1_uc011kyg.1_Splice_Site_p.V313_splice|MTUS1_uc010lsy.2_Splice_Site|MTUS1_uc003wxw.2_Splice_Site_p.V1114_splice|MTUS1_uc003wxs.2_Splice_Site_p.V334_splice	NM_001001924	NP_001001924			mitochondrial tumor suppressor 1 isoform 1							Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				ovary(1)|skin(1)	2				Colorectal(111;0.0778)														---	---	---	---
DUSP4	1846	broad.mit.edu	37	8	29194829	29194829	+	Missense_Mutation	SNP	C	A	A	rs144675383		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:29194829C>A	uc003xhm.2	-	4	1289	c.899G>T	c.(898-900)CGG>CTG	p.R300L	DUSP4_uc003xhl.2_Missense_Mutation_p.R209L	NM_001394	NP_001385	Q13115	DUS4_HUMAN	dual specificity phosphatase 4 isoform 1	300	Tyrosine-protein phosphatase.				endoderm formation|inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/threonine phosphatase activity			lung(1)	1				KIRC - Kidney renal clear cell carcinoma(542;0.094)|Kidney(114;0.113)														---	---	---	---
MCM4	4173	broad.mit.edu	37	8	48883436	48883436	+	Silent	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:48883436G>A	uc003xqk.1	+	12	1895	c.1800G>A	c.(1798-1800)AAG>AAA	p.K600K	MCM4_uc003xql.1_Silent_p.K600K|MCM4_uc011ldi.1_Silent_p.K587K	NM_182746	NP_877423	P33991	MCM4_HUMAN	minichromosome maintenance complex component 4	600	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(2)|skin(2)	4		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)																---	---	---	---
PREX2	80243	broad.mit.edu	37	8	68942747	68942747	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:68942747A>G	uc003xxv.1	+	6	586	c.559A>G	c.(559-561)ACT>GCT	p.T187A	PREX2_uc003xxu.1_Missense_Mutation_p.T187A|PREX2_uc011lez.1_Missense_Mutation_p.T122A	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	187	DH.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17																		---	---	---	---
ZFHX4	79776	broad.mit.edu	37	8	77764117	77764117	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:77764117A>G	uc003yav.2	+	10	5212	c.4825A>G	c.(4825-4827)AGT>GGT	p.S1609G	ZFHX4_uc003yau.1_Missense_Mutation_p.S1654G|ZFHX4_uc003yaw.1_Missense_Mutation_p.S1609G	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1609						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)												HNSCC(33;0.089)			---	---	---	---
ZFPM2	23414	broad.mit.edu	37	8	106813442	106813442	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:106813442T>G	uc003ymd.2	+	8	1155	c.1132T>G	c.(1132-1134)TTA>GTA	p.L378V	ZFPM2_uc011lhs.1_Missense_Mutation_p.L109V|uc003yme.1_5'Flank	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	378	C2H2-type 3.				blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)															---	---	---	---
C8orf85	441376	broad.mit.edu	37	8	117954916	117954916	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:117954916A>C	uc003yof.2	+	2	463	c.444A>C	c.(442-444)AAA>AAC	p.K148N		NM_001025357	NP_001020528	Q4LEZ3	AARD_HUMAN	alanine and arginine-rich domain-containing	148											0																		---	---	---	---
FER1L6	654463	broad.mit.edu	37	8	125082784	125082784	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:125082784A>G	uc003yqw.2	+	30	4117	c.3911A>G	c.(3910-3912)AAG>AGG	p.K1304R	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1304	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)															---	---	---	---
GSDMC	56169	broad.mit.edu	37	8	130761760	130761760	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:130761760A>C	uc003ysr.2	-	13	2107	c.1225T>G	c.(1225-1227)TTC>GTC	p.F409V		NM_031415	NP_113603	Q9BYG8	GSDMC_HUMAN	melanoma-derived leucine zipper, extra-nuclear	409						mitochondrion				ovary(2)|skin(1)	3																		---	---	---	---
TG	7038	broad.mit.edu	37	8	133899716	133899716	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:133899716A>G	uc003ytw.2	+	9	2140	c.2099A>G	c.(2098-2100)AAC>AGC	p.N700S		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	700	Thyroglobulin type-1 6.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)														---	---	---	---
HSF1	3297	broad.mit.edu	37	8	145535734	145535734	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145535734G>T	uc003zbt.3	+	9	1116	c.946G>T	c.(946-948)GGG>TGG	p.G316W	HSF1_uc003zbu.3_RNA	NM_005526	NP_005517	Q00613	HSF1_HUMAN	heat shock transcription factor 1	316						cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.94e-40)|Epithelial(56;1.12e-39)|all cancers(56;9.11e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0547)|Colorectal(110;0.055)															---	---	---	---
SMARCA2	6595	broad.mit.edu	37	9	2123719	2123719	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:2123719C>T	uc003zhc.2	+	27	3862	c.3763C>T	c.(3763-3765)CGG>TGG	p.R1255W	SMARCA2_uc003zhd.2_Missense_Mutation_p.R1255W|SMARCA2_uc010mha.2_Missense_Mutation_p.R1188W	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	1255					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)														---	---	---	---
ACO1	48	broad.mit.edu	37	9	32434703	32434703	+	Intron	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:32434703A>C	uc003zqw.3	+						ACO1_uc010mjh.1_Intron|ACO1_uc003zqx.3_Intron|ACO1_uc003zqy.3_Intron	NM_002197	NP_002188			aconitase 1						citrate metabolic process|response to iron(II) ion|tricarboxylic acid cycle	cytosol|endoplasmic reticulum|Golgi apparatus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron-responsive element binding|isocitrate hydro-lyase (cis-aconitate-forming) activity|metal ion binding|protein binding				0			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;3.94e-06)														---	---	---	---
RNF38	152006	broad.mit.edu	37	9	36357894	36357894	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:36357894C>T	uc003zzh.2	-	5	807	c.616G>A	c.(616-618)GCA>ACA	p.A206T	RNF38_uc003zzi.2_Missense_Mutation_p.A156T|RNF38_uc003zzj.2_Missense_Mutation_p.A123T|RNF38_uc003zzk.2_Missense_Mutation_p.A123T|RNF38_uc003zzl.2_Missense_Mutation_p.A130T|RNF38_uc003zzm.2_Missense_Mutation_p.A123T	NM_022781	NP_073618	Q9H0F5	RNF38_HUMAN	ring finger protein 38 isoform 1	206			A -> T.				zinc ion binding			central_nervous_system(1)	1			STAD - Stomach adenocarcinoma(86;0.228)															---	---	---	---
TRPM3	80036	broad.mit.edu	37	9	73240173	73240173	+	Silent	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:73240173A>C	uc004aid.2	-	13	1951	c.1707T>G	c.(1705-1707)GCT>GCG	p.A569A	TRPM3_uc004ahu.2_Silent_p.A399A|TRPM3_uc004ahv.2_Silent_p.A381A|TRPM3_uc004ahw.2_Silent_p.A441A|TRPM3_uc004ahx.2_Silent_p.A428A|TRPM3_uc004ahy.2_Silent_p.A441A|TRPM3_uc004ahz.2_Silent_p.A428A|TRPM3_uc004aia.2_Silent_p.A416A|TRPM3_uc004aib.2_Silent_p.A416A|TRPM3_uc004aic.2_Silent_p.A569A	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	594	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9																		---	---	---	---
FOXE1	2304	broad.mit.edu	37	9	100616468	100616468	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:100616468G>A	uc004axu.2	+	1	932	c.272G>A	c.(271-273)CGC>CAC	p.R91H		NM_004473	NP_004464	O00358	FOXE1_HUMAN	forkhead box E1	91	Fork-head.				cell migration|embryonic organ morphogenesis|hair follicle morphogenesis|hard palate development|lens morphogenesis in camera-type eye|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|peripheral nervous system development|pharynx development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|soft palate development|thymus development|thyroid gland development|thyroid hormone generation	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0		Acute lymphoblastic leukemia(62;0.158)																---	---	---	---
LPPR1	54886	broad.mit.edu	37	9	104075105	104075105	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:104075105C>T	uc004bbb.2	+	6	1061	c.662C>T	c.(661-663)ACG>ATG	p.T221M	LPPR1_uc011lvi.1_Missense_Mutation_p.T197M|LPPR1_uc004bbc.2_Missense_Mutation_p.T221M|LPPR1_uc010mtc.2_Missense_Mutation_p.T205M	NM_207299	NP_997182	Q8TBJ4	LPPR1_HUMAN	plasticity related gene 3	221						integral to membrane	catalytic activity				0																		---	---	---	---
ZNF462	58499	broad.mit.edu	37	9	109736459	109736459	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:109736459T>C	uc004bcz.2	+	9	7026	c.6737T>C	c.(6736-6738)GTT>GCT	p.V2246A	ZNF462_uc010mto.2_Missense_Mutation_p.V2155A|ZNF462_uc004bda.2_Missense_Mutation_p.V2154A|ZNF462_uc011lvz.1_Missense_Mutation_p.V203A|ZNF462_uc004bdb.1_Missense_Mutation_p.V154A	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	2246					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5																		---	---	---	---
IKBKAP	8518	broad.mit.edu	37	9	111642333	111642333	+	Silent	SNP	C	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:111642333C>A	uc004bdm.3	-	32	3979	c.3459G>T	c.(3457-3459)CTG>CTT	p.L1153L	IKBKAP_uc004bdl.2_Silent_p.L804L|IKBKAP_uc011lwc.1_Silent_p.L1039L|IKBKAP_uc010mtq.2_Silent_p.L804L|IKBKAP_uc004bdk.2_Silent_p.L157L|IKBKAP_uc010mtp.2_RNA	NM_003640	NP_003631	O95163	ELP1_HUMAN	inhibitor of kappa light polypeptide gene	1153					immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	7																		---	---	---	---
OR2K2	26248	broad.mit.edu	37	9	114090461	114090461	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:114090461A>C	uc011lwp.1	-	1	253	c.253T>G	c.(253-255)TTG>GTG	p.L85V		NM_205859	NP_995581	Q8NGT1	OR2K2_HUMAN	olfactory receptor, family 2, subfamily K,	114	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1																		---	---	---	---
TLR4	7099	broad.mit.edu	37	9	120475898	120475898	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:120475898T>G	uc004bjz.2	+	3	1783	c.1492T>G	c.(1492-1494)TTG>GTG	p.L498V	TLR4_uc004bka.2_Missense_Mutation_p.L458V|TLR4_uc004bkb.2_Missense_Mutation_p.L298V	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	498	LRR 16.|Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16																		---	---	---	---
STRBP	55342	broad.mit.edu	37	9	125936031	125936031	+	Silent	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:125936031C>T	uc004bns.2	-	5	745	c.315G>A	c.(313-315)CTG>CTA	p.L105L	STRBP_uc004bnt.2_5'UTR|STRBP_uc004bnu.2_Silent_p.L91L|STRBP_uc004bnv.2_Silent_p.L105L	NM_018387	NP_060857	Q96SI9	STRBP_HUMAN	spermatid perinuclear RNA binding protein	105	DZF.				multicellular organismal development	cytoplasm|nucleus	DNA binding			breast(1)|skin(1)	2																		---	---	---	---
NEBL	10529	broad.mit.edu	37	10	21139351	21139351	+	Silent	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:21139351T>G	uc001iqi.2	-	11	1486	c.1089A>C	c.(1087-1089)TCA>TCC	p.S363S	NEBL_uc001iqj.2_RNA|NEBL_uc001iqk.2_Intron	NM_006393	NP_006384	O76041	NEBL_HUMAN	nebulette sarcomeric isoform	363	Nebulin 10.				regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2																		---	---	---	---
PGBD3	267004	broad.mit.edu	37	10	50724274	50724274	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:50724274T>G	uc001jht.2	-	2	1142	c.887A>C	c.(886-888)AAG>ACG	p.K296T	ERCC6_uc001jhs.3_Intron|PGBD3_uc009xoe.2_Missense_Mutation_p.K764T|PGBD3_uc001jhu.2_Missense_Mutation_p.K764T	NM_170753	NP_736609	Q8N328	PGBD3_HUMAN	hypothetical protein LOC267004	296										pancreas(1)|breast(1)|skin(1)	3																		---	---	---	---
PCDH15	65217	broad.mit.edu	37	10	55700715	55700715	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:55700715A>G	uc001jju.1	-	24	3538	c.3143T>C	c.(3142-3144)CTT>CCT	p.L1048P	PCDH15_uc010qhq.1_Missense_Mutation_p.L1053P|PCDH15_uc010qhr.1_Missense_Mutation_p.L1048P|PCDH15_uc010qhs.1_Missense_Mutation_p.L1060P|PCDH15_uc010qht.1_Missense_Mutation_p.L1055P|PCDH15_uc010qhu.1_Missense_Mutation_p.L1048P|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.L1048P|PCDH15_uc010qhw.1_Missense_Mutation_p.L1011P|PCDH15_uc010qhx.1_Missense_Mutation_p.L977P|PCDH15_uc010qhy.1_Missense_Mutation_p.L1053P|PCDH15_uc010qhz.1_Missense_Mutation_p.L1048P|PCDH15_uc010qia.1_Missense_Mutation_p.L1026P|PCDH15_uc010qib.1_Missense_Mutation_p.L1026P	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1048	Cadherin 10.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)													HNSCC(58;0.16)			---	---	---	---
ARHGAP19	84986	broad.mit.edu	37	10	99019212	99019212	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:99019212A>C	uc001knb.2	-	5	816	c.787T>G	c.(787-789)TCA>GCA	p.S263A	ARHGAP19_uc001kmy.2_RNA|ARHGAP19_uc001kna.2_Missense_Mutation_p.S254A|ARHGAP19_uc009xvi.2_RNA|ARHGAP19_uc009xvj.2_Missense_Mutation_p.S263A|ARHGAP19_uc009xvk.2_Missense_Mutation_p.S57A	NM_032900	NP_116289	Q14CB8	RHG19_HUMAN	Rho GTPase activating protein 19	263	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	GTPase activator activity				0		Colorectal(252;0.0854)		Epithelial(162;7.65e-09)|all cancers(201;4.49e-07)														---	---	---	---
CPN1	1369	broad.mit.edu	37	10	101802248	101802248	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:101802248T>G	uc001kql.2	-	9	1573	c.1313A>C	c.(1312-1314)AAA>ACA	p.K438T		NM_001308	NP_001299	P15169	CBPN_HUMAN	carboxypeptidase N, polypeptide 1 precursor	438					proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(3)|pancreas(1)	4		Colorectal(252;0.234)		Epithelial(162;4.77e-10)|all cancers(201;3.82e-08)														---	---	---	---
NOLC1	9221	broad.mit.edu	37	10	103919991	103919991	+	Missense_Mutation	SNP	T	G	G	rs151088360	byFrequency	TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:103919991T>G	uc001kuo.2	+	9	1225	c.990T>G	c.(988-990)GAT>GAG	p.D330E	NOLC1_uc001kup.2_Missense_Mutation_p.D340E|NOLC1_uc001kuq.2_Missense_Mutation_p.D331E|NOLC1_uc009xxb.1_Missense_Mutation_p.D49E|NOLC1_uc001kur.2_Missense_Mutation_p.D49E	NM_004741	NP_004732	Q14978	NOLC1_HUMAN	nucleolar and coiled-body phosphoprotein 1	330	11 X 12 AA approximate repeats of an acidic serine cluster.|Interacts with RPA194.|Acidic serine cluster 6.				mitosis|rRNA processing	cytoplasm|nucleolus	ATP binding|GTP binding|protein binding			ovary(1)	1		Colorectal(252;0.122)		Epithelial(162;5.19e-08)|all cancers(201;9.43e-07)														---	---	---	---
TRIM8	81603	broad.mit.edu	37	10	104416988	104416988	+	Silent	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:104416988C>T	uc001kvz.2	+	6	1656	c.1533C>T	c.(1531-1533)TCC>TCT	p.S511S		NM_030912	NP_112174	Q9BZR9	TRIM8_HUMAN	tripartite motif-containing 8	511						cytoplasm|PML body	ligase activity|protein homodimerization activity|zinc ion binding			ovary(1)	1		Colorectal(252;0.122)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)														---	---	---	---
PNLIPRP3	119548	broad.mit.edu	37	10	118236234	118236234	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:118236234A>C	uc001lcl.3	+	11	1344	c.1243A>C	c.(1243-1245)AGT>CGT	p.S415R		NM_001011709	NP_001011709	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3 precursor	415	PLAT.				lipid catabolic process	extracellular region	triglyceride lipase activity	p.S415C(1)		ovary(1)	1				all cancers(201;0.0131)														---	---	---	---
SLC18A2	6571	broad.mit.edu	37	10	119003515	119003515	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:119003515A>C	uc001ldd.1	+	3	186	c.155A>C	c.(154-156)AAG>ACG	p.K52T	SLC18A2_uc009xyy.1_5'UTR	NM_003054	NP_003045	Q05940	VMAT2_HUMAN	solute carrier family 18 (vesicular monoamine),	52	Lumenal, vesicle (Potential).				neurotransmitter secretion	clathrin sculpted monoamine transport vesicle membrane|integral to plasma membrane|membrane fraction	monoamine transmembrane transporter activity				0		Colorectal(252;0.19)		all cancers(201;0.029)	Alseroxylon(DB00386)|Reserpine(DB00206)|Tetrabenazine(DB04844)													---	---	---	---
TACC2	10579	broad.mit.edu	37	10	123843481	123843481	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:123843481T>C	uc001lfv.2	+	4	1826	c.1466T>C	c.(1465-1467)GTT>GCT	p.V489A	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Missense_Mutation_p.V489A|TACC2_uc010qtv.1_Missense_Mutation_p.V489A	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	489	Pro-rich.					microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)																---	---	---	---
OR51G1	79324	broad.mit.edu	37	11	4945175	4945175	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:4945175A>C	uc010qyr.1	-	1	395	c.395T>G	c.(394-396)CTG>CGG	p.L132R		NM_001005237	NP_001005237	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G,	132	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)														---	---	---	---
OR56A3	390083	broad.mit.edu	37	11	5969389	5969389	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:5969389A>C	uc010qzt.1	+	1	813	c.813A>C	c.(811-813)AAA>AAC	p.K271N		NM_001003443	NP_001003443	Q8NH54	O56A3_HUMAN	olfactory receptor, family 56, subfamily A,	271	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;9.41e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)														---	---	---	---
USH1C	10083	broad.mit.edu	37	11	17532052	17532052	+	Intron	SNP	C	A	A	rs146333270		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:17532052C>A	uc001mnf.2	-						USH1C_uc001mne.2_Missense_Mutation_p.R477L|USH1C_uc009yhb.2_Intron|USH1C_uc001mng.2_Intron|USH1C_uc001mnd.2_Intron	NM_005709	NP_005700			harmonin isoform a						equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			ovary(1)	1																		---	---	---	---
LRP4	4038	broad.mit.edu	37	11	46896598	46896598	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:46896598G>A	uc001ndn.3	-	28	4128	c.3982C>T	c.(3982-3984)CCT>TCT	p.P1328S		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	1328	Extracellular (Potential).				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)														---	---	---	---
OR4C6	219432	broad.mit.edu	37	11	55433389	55433389	+	Missense_Mutation	SNP	T	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55433389T>A	uc001nht.3	+	3	1012	c.747T>A	c.(745-747)TTT>TTA	p.F249L	OR4C6_uc010rik.1_Missense_Mutation_p.F249L	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	249	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2																		---	---	---	---
OR4C6	219432	broad.mit.edu	37	11	55433390	55433390	+	Missense_Mutation	SNP	G	T	T	rs75211559		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55433390G>T	uc001nht.3	+	3	1013	c.748G>T	c.(748-750)GTC>TTC	p.V250F	OR4C6_uc010rik.1_Missense_Mutation_p.V250F	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	250	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2																		---	---	---	---
OR5D14	219436	broad.mit.edu	37	11	55563569	55563569	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55563569T>C	uc010rim.1	+	1	538	c.538T>C	c.(538-540)TTT>CTT	p.F180L		NM_001004735	NP_001004735	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D,	180	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3		all_epithelial(135;0.196)																---	---	---	---
MS4A6A	64231	broad.mit.edu	37	11	59949151	59949151	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:59949151T>G	uc001nor.2	-	2	288	c.50A>C	c.(49-51)AAT>ACT	p.N17T	MS4A6A_uc001noq.2_Missense_Mutation_p.N17T|MS4A6A_uc001nos.3_Missense_Mutation_p.N45T|MS4A6A_uc009ymv.2_Missense_Mutation_p.N17T|MS4A6A_uc001not.2_Missense_Mutation_p.N17T|MS4A6A_uc010rla.1_Missense_Mutation_p.N45T|MS4A6A_uc010rlb.1_Missense_Mutation_p.N17T	NM_152852	NP_690591	Q9H2W1	M4A6A_HUMAN	membrane-spanning 4-domains, subfamily A, member	17	Cytoplasmic (Potential).					integral to membrane	receptor activity				0																		---	---	---	---
MS4A10	341116	broad.mit.edu	37	11	60561521	60561521	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:60561521T>C	uc001npz.1	+	5	533	c.437T>C	c.(436-438)CTC>CCC	p.L146P		NM_206893	NP_996776	Q96PG2	M4A10_HUMAN	membrane-spanning 4-domains, subfamily A, member	146	Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|skin(1)	2																		---	---	---	---
NUMA1	4926	broad.mit.edu	37	11	71724063	71724063	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:71724063G>A	uc001orl.1	-	15	4658	c.4486C>T	c.(4486-4488)CGA>TGA	p.R1496*	NUMA1_uc009ysw.1_Nonsense_Mutation_p.R1059*|NUMA1_uc001ork.1_Intron|NUMA1_uc001orm.1_Nonsense_Mutation_p.R1496*|NUMA1_uc001orn.2_Nonsense_Mutation_p.R1059*|NUMA1_uc009ysx.1_Nonsense_Mutation_p.R1496*|NUMA1_uc001oro.1_Nonsense_Mutation_p.R1496*	NM_006185	NP_006176	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	1496	Potential.				G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			ovary(3)|lung(2)|skin(2)|central_nervous_system(1)	8								T	RARA	APL								---	---	---	---
GPR83	10888	broad.mit.edu	37	11	94113847	94113847	+	Missense_Mutation	SNP	A	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:94113847A>T	uc001pet.2	-	4	912	c.740T>A	c.(739-741)CTC>CAC	p.L247H		NM_016540	NP_057624	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83 precursor	247	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			central_nervous_system(2)|ovary(1)	3		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)																---	---	---	---
USP28	57646	broad.mit.edu	37	11	113674571	113674571	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:113674571C>T	uc001poh.2	-	22	2720	c.2687G>A	c.(2686-2688)CGA>CAA	p.R896Q	USP28_uc001pog.2_Missense_Mutation_p.R572Q|USP28_uc010rwy.1_Missense_Mutation_p.R739Q|USP28_uc001poi.2_Missense_Mutation_p.R219Q	NM_020886	NP_065937	Q96RU2	UBP28_HUMAN	ubiquitin specific protease 28	896					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|breast(2)|ovary(1)|large_intestine(1)|kidney(1)	7		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)														---	---	---	---
A2ML1	144568	broad.mit.edu	37	12	8998053	8998053	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:8998053A>C	uc001quz.3	+	13	1590	c.1492A>C	c.(1492-1494)AGT>CGT	p.S498R	A2ML1_uc001qva.1_Missense_Mutation_p.S78R|A2ML1_uc010sgm.1_5'UTR	NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	342						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3																		---	---	---	---
LRRK2	120892	broad.mit.edu	37	12	40716140	40716140	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:40716140A>C	uc001rmg.3	+	37	5458	c.5337A>C	c.(5335-5337)CAA>CAC	p.Q1779H	LRRK2_uc009zjw.2_Missense_Mutation_p.Q617H|LRRK2_uc001rmi.2_Missense_Mutation_p.Q612H	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1779					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)																---	---	---	---
TMEM117	84216	broad.mit.edu	37	12	44782372	44782372	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:44782372T>G	uc001rod.2	+	8	1528	c.1462T>G	c.(1462-1464)TTG>GTG	p.L488V	TMEM117_uc001roe.2_Missense_Mutation_p.L384V|TMEM117_uc009zkc.2_3'UTR	NM_032256	NP_115632	Q9H0C3	TM117_HUMAN	transmembrane protein 117	488						endoplasmic reticulum|integral to membrane					0	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.124)														---	---	---	---
ERBB3	2065	broad.mit.edu	37	12	56478854	56478854	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56478854G>T	uc001sjh.2	+	3	503	c.310G>T	c.(310-312)GTG>TTG	p.V104L	ERBB3_uc009zoj.2_RNA|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Missense_Mutation_p.V45L|ERBB3_uc001sjg.2_Missense_Mutation_p.V104L	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	104	Extracellular (Potential).		V -> M (in an ovarian mucinous carcinoma sample; somatic mutation).		cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity	p.V104M(1)		lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)															---	---	---	---
ESYT1	23344	broad.mit.edu	37	12	56525562	56525562	+	Silent	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56525562C>T	uc001sjq.2	+	7	884	c.834C>T	c.(832-834)ACC>ACT	p.T278T	ESYT1_uc001sjr.2_Silent_p.T278T	NM_015292	NP_056107	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	278						integral to membrane				ovary(4)|skin(1)	5																		---	---	---	---
MYF6	4618	broad.mit.edu	37	12	81101582	81101582	+	Silent	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:81101582A>G	uc001szf.1	+	1	137	c.84A>G	c.(82-84)GCA>GCG	p.A28A		NM_002469	NP_002460	P23409	MYF6_HUMAN	myogenic factor 6	28					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1																		---	---	---	---
NR1H4	9971	broad.mit.edu	37	12	100904824	100904824	+	Silent	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:100904824G>A	uc001tht.1	+	2	406	c.378G>A	c.(376-378)GCG>GCA	p.A126A	NR1H4_uc001thp.1_Silent_p.A116A|NR1H4_uc001thq.1_Silent_p.A116A|NR1H4_uc010svj.1_RNA|NR1H4_uc001thr.1_Silent_p.A116A|NR1H4_uc010svk.1_Silent_p.A116A|NR1H4_uc001ths.1_Silent_p.A126A	NM_005123	NP_005114	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	126					bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding	p.A116A(1)		ovary(1)|lung(1)|skin(1)	3																		---	---	---	---
STAB2	55576	broad.mit.edu	37	12	104144357	104144357	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:104144357G>A	uc001tjw.2	+	60	6625	c.6439G>A	c.(6439-6441)GGC>AGC	p.G2147S	STAB2_uc009zug.2_RNA	NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	2147	Extracellular (Potential).|EGF-like 17.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14																		---	---	---	---
DAO	1610	broad.mit.edu	37	12	109294207	109294207	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:109294207T>C	uc001tnr.3	+	11	1093	c.940T>C	c.(940-942)TAC>CAC	p.Y314H	DAO_uc001tnq.3_Missense_Mutation_p.Y248H|DAO_uc009zvb.2_RNA|DAO_uc001tns.3_RNA	NM_001917	NP_001908	P14920	OXDA_HUMAN	D-amino-acid oxidase	314	FAD.				glyoxylate metabolic process	peroxisomal matrix	binding|D-amino-acid oxidase activity			ovary(1)|skin(1)	2																		---	---	---	---
ACACB	32	broad.mit.edu	37	12	109612047	109612047	+	Intron	SNP	C	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:109612047C>A	uc001tob.2	+						ACACB_uc001toc.2_Intron	NM_001093	NP_001084			acetyl-Coenzyme A carboxylase beta						acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)													---	---	---	---
UBE3B	89910	broad.mit.edu	37	12	109959319	109959319	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:109959319A>G	uc001top.2	+	21	2930	c.2327A>G	c.(2326-2328)GAG>GGG	p.E776G	UBE3B_uc001toq.2_Missense_Mutation_p.E776G|UBE3B_uc001tos.2_Missense_Mutation_p.E203G|UBE3B_uc001too.1_RNA|UBE3B_uc009zvj.1_Missense_Mutation_p.E776G	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	776	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4																		---	---	---	---
TMEM132D	121256	broad.mit.edu	37	12	129566470	129566470	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:129566470T>G	uc009zyl.1	-	7	2085	c.1757A>C	c.(1756-1758)GAG>GCG	p.E586A	TMEM132D_uc001uia.2_Missense_Mutation_p.E124A	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	586	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)														---	---	---	---
PARP4	143	broad.mit.edu	37	13	25049733	25049733	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:25049733A>C	uc001upl.2	-	15	1897	c.1791T>G	c.(1789-1791)GAT>GAG	p.D597E	PARP4_uc010tdc.1_Missense_Mutation_p.D597E	NM_006437	NP_006428	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	597					cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity	p.D597H(1)		ovary(3)|skin(1)	4		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)														---	---	---	---
NALCN	259232	broad.mit.edu	37	13	101944618	101944618	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:101944618A>G	uc001vox.1	-	8	1088	c.899T>C	c.(898-900)TTC>TCC	p.F300S	NALCN_uc001voy.2_Missense_Mutation_p.F15S|NALCN_uc001voz.2_Missense_Mutation_p.F300S|NALCN_uc001vpa.2_Missense_Mutation_p.F300S	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	300	Extracellular (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)																	---	---	---	---
Unknown	0	broad.mit.edu	37	14	22783282	22783282	+	Intron	SNP	A	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:22783282A>T	uc001wbw.2	+						uc010aja.1_Intron|uc010tmk.1_Intron|uc010tmo.1_Intron|uc001wco.2_Intron|uc010aje.1_Intron|uc001wcp.2_Intron|uc001wcr.1_Intron|uc001wcs.1_Intron|uc010ajf.1_Intron|uc010ajg.1_Intron|uc001wcx.3_Intron|uc001wdd.2_Intron|uc010ajj.1_Intron|uc001wde.1_Intron|uc001wdf.2_Intron|uc010ajk.1_Intron|uc001wdg.1_Intron|uc010ajl.1_Intron|uc001wdj.2_Intron|uc010ajo.1_Intron|uc010ajp.1_Intron|uc001wdq.2_Missense_Mutation_p.K93I					SubName: Full=Alpha-chain C region; Flags: Fragment;																														---	---	---	---
LTB4R	1241	broad.mit.edu	37	14	24785153	24785153	+	Missense_Mutation	SNP	T	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:24785153T>A	uc001wos.2	+	2	617	c.296T>A	c.(295-297)GTC>GAC	p.V99D	LTB4R_uc010alp.2_Missense_Mutation_p.V99D|LTB4R_uc001wou.2_Missense_Mutation_p.V99D	NM_001143919	NP_001137391	Q15722	LT4R1_HUMAN	leukotriene B4 receptor	99	Helical; Name=3; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular component movement|immune response|inflammatory response|muscle contraction	integral to plasma membrane	nucleotide binding				0				GBM - Glioblastoma multiforme(265;0.018)														---	---	---	---
RALGAPA1	253959	broad.mit.edu	37	14	36096777	36096777	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:36096777T>C	uc001wti.2	-	33	5249	c.4858A>G	c.(4858-4860)AGT>GGT	p.S1620G	RALGAPA1_uc010amp.2_RNA|RALGAPA1_uc001wtj.2_Missense_Mutation_p.S1620G|RALGAPA1_uc010tpv.1_Missense_Mutation_p.S1633G|RALGAPA1_uc010tpw.1_Missense_Mutation_p.S1667G	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	1620	Minimal domain that binds to TCF3/E12 (By similarity).				activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4																		---	---	---	---
FSCB	84075	broad.mit.edu	37	14	44975246	44975246	+	Silent	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:44975246T>C	uc001wvn.2	-	1	1254	c.945A>G	c.(943-945)AAA>AAG	p.K315K		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	315						cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)														---	---	---	---
MAX	4149	broad.mit.edu	37	14	65544747	65544747	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:65544747C>T	uc001xif.1	-	4	349	c.179G>A	c.(178-180)CGG>CAG	p.R60Q	MAX_uc001xic.1_Intron|MAX_uc001xie.1_Missense_Mutation_p.R60Q|MAX_uc010aql.1_Intron|MAX_uc001xig.1_Missense_Mutation_p.R51Q|MAX_uc001xih.1_RNA|MAX_uc001xii.1_Missense_Mutation_p.R51Q|MAX_uc001xij.1_Missense_Mutation_p.R60Q	NM_002382	NP_002373	P61244	MAX_HUMAN	MAX protein isoform a	60	Helix-loop-helix motif.				transcription from RNA polymerase II promoter	cytoplasm|MLL1 complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			lung(1)	1				all cancers(60;0.000776)|OV - Ovarian serous cystadenocarcinoma(108;0.00359)|BRCA - Breast invasive adenocarcinoma(234;0.00999)														---	---	---	---
KIAA1409	57578	broad.mit.edu	37	14	94007143	94007143	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:94007143A>G	uc001ybv.1	+	10	1042	c.959A>G	c.(958-960)CAG>CGG	p.Q320R	KIAA1409_uc001ybs.1_Missense_Mutation_p.Q320R|KIAA1409_uc001ybu.1_Missense_Mutation_p.Q258R	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	497						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)														---	---	---	---
C14orf49	161176	broad.mit.edu	37	14	95912417	95912417	+	Missense_Mutation	SNP	C	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:95912417C>G	uc001yei.3	-	8	1476	c.1461G>C	c.(1459-1461)ATG>ATC	p.M487I	C14orf49_uc010avi.2_Missense_Mutation_p.M487I|C14orf49_uc001yej.1_Missense_Mutation_p.M487I	NM_152592	NP_689805	Q6ZMZ3	SYNE3_HUMAN	nesprin-3	487	Cytoplasmic (Potential).				cytoskeletal anchoring at nuclear membrane	integral to membrane|nuclear outer membrane|SUN-KASH complex	actin binding			central_nervous_system(1)	1		all_cancers(154;0.0937)		COAD - Colon adenocarcinoma(157;0.245)														---	---	---	---
OR4N4	283694	broad.mit.edu	37	15	22382731	22382731	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:22382731T>G	uc001yuc.1	+	7	1240	c.259T>G	c.(259-261)TCT>GCT	p.S87A	LOC727924_uc001yub.1_RNA|OR4N4_uc010tzv.1_Missense_Mutation_p.S87A	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,	87	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)														---	---	---	---
PAR4	347745	broad.mit.edu	37	15	25456941	25456941	+	Intron	SNP	T	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:25456941T>A	uc001yzk.1	+						PAR4_uc010ayo.1_Intron|SNORD115-20_uc001yzq.1_Intron|PAR4_uc001yzs.2_RNA|uc001yzt.1_5'Flank|HBII-52-24_uc010ayp.1_5'Flank					Homo sapiens clone Rt-13I SNURF-SNRPN mRNA, downstream untranslated exons, alternatively spliced.												0																		---	---	---	---
SLC12A6	9990	broad.mit.edu	37	15	34533513	34533513	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:34533513T>C	uc001zhw.2	-	17	2352	c.2188A>G	c.(2188-2190)ATC>GTC	p.I730V	SLC12A6_uc001zhv.2_Missense_Mutation_p.I679V|SLC12A6_uc001zhx.2_Missense_Mutation_p.I715V|SLC12A6_uc001zhy.2_RNA|SLC12A6_uc001zhz.2_RNA|SLC12A6_uc001zia.2_Missense_Mutation_p.I671V|SLC12A6_uc001zib.2_Missense_Mutation_p.I721V|SLC12A6_uc001zic.2_Missense_Mutation_p.I730V|SLC12A6_uc010bau.2_Missense_Mutation_p.I730V|SLC12A6_uc001zid.2_Missense_Mutation_p.I671V|SLC12A6_uc001zht.2_RNA|SLC12A6_uc001zhu.2_Missense_Mutation_p.I542V	NM_133647	NP_598408	Q9UHW9	S12A6_HUMAN	solute carrier family 12, member 6 isoform a	730					angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|ovary(1)|skin(1)	7		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)													---	---	---	---
GPR176	11245	broad.mit.edu	37	15	40094058	40094058	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:40094058A>G	uc001zkj.1	-	3	1689	c.823T>C	c.(823-825)TTC>CTC	p.F275L	GPR176_uc010uck.1_Missense_Mutation_p.F215L	NM_007223	NP_009154	Q14439	GP176_HUMAN	G protein-coupled receptor 176	275	Helical; Name=6; (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity			ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		all_cancers(109;4.05e-15)|all_epithelial(112;2.96e-13)|Lung NSC(122;8.53e-11)|all_lung(180;2.71e-09)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;4.4e-06)|BRCA - Breast invasive adenocarcinoma(123;0.123)												OREG0023053	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
NDUFAF1	51103	broad.mit.edu	37	15	41679693	41679693	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:41679693T>G	uc001znx.2	-	5	1315	c.933A>C	c.(931-933)GAA>GAC	p.E311D	NDUFAF1_uc010bcf.2_RNA	NM_016013	NP_057097	Q9Y375	CIA30_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	311					mitochondrial electron transport, NADH to ubiquinone|protein complex assembly	mitochondrial respiratory chain complex I	unfolded protein binding			ovary(1)	1		all_cancers(109;5.07e-19)|all_epithelial(112;2.43e-16)|Lung NSC(122;1.81e-11)|all_lung(180;4.81e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;8e-17)|GBM - Glioblastoma multiforme(113;1.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.114)														---	---	---	---
MGA	23269	broad.mit.edu	37	15	42040962	42040962	+	Silent	SNP	A	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:42040962A>T	uc010ucy.1	+	16	5521	c.5340A>T	c.(5338-5340)ACA>ACT	p.T1780T	MGA_uc010ucz.1_Silent_p.T1571T|MGA_uc010uda.1_Silent_p.T396T|MGA_uc001zoi.2_5'UTR	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)														---	---	---	---
C15orf39	56905	broad.mit.edu	37	15	75500605	75500605	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:75500605G>T	uc002azp.3	+	2	2536	c.2216G>T	c.(2215-2217)CGG>CTG	p.R739L	C15orf39_uc002azq.3_Missense_Mutation_p.R739L|C15orf39_uc002azr.3_Missense_Mutation_p.R137L	NM_015492	NP_056307	Q6ZRI6	CO039_HUMAN	hypothetical protein LOC56905	739											0																		---	---	---	---
DNAJA4	55466	broad.mit.edu	37	15	78566640	78566640	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:78566640A>G	uc002bdj.1	+	4	637	c.520A>G	c.(520-522)ATC>GTC	p.I174V	DNAJA4_uc002bdi.2_Missense_Mutation_p.I203V|DNAJA4_uc002bdk.2_Missense_Mutation_p.I147V|DNAJA4_uc002bdl.2_Missense_Mutation_p.I89V|DNAJA4_uc002bdm.1_5'Flank	NM_001130182	NP_001123654	Q8WW22	DNJA4_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 4	174	CR-type.				protein folding|response to heat	membrane	ATP binding|heat shock protein binding|metal ion binding|unfolded protein binding			skin(1)	1																		---	---	---	---
OR4F6	390648	broad.mit.edu	37	15	102346405	102346405	+	Silent	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:102346405T>C	uc010utr.1	+	1	483	c.483T>C	c.(481-483)GCT>GCC	p.A161A		NM_001005326	NP_001005326	Q8NGB9	OR4F6_HUMAN	olfactory receptor, family 4, subfamily F,	161	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)															---	---	---	---
NETO2	81831	broad.mit.edu	37	16	47117496	47117496	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:47117496T>C	uc002eer.1	-	9	1599	c.1214A>G	c.(1213-1215)GAC>GGC	p.D405G	NETO2_uc002eeq.1_Missense_Mutation_p.D140G|NETO2_uc010vgf.1_Missense_Mutation_p.D262G	NM_018092	NP_060562	Q8NC67	NETO2_HUMAN	neuropilin- and tolloid-like protein 2	405	Cytoplasmic (Potential).					integral to membrane	receptor activity				0		all_cancers(37;0.00114)|all_lung(18;0.00432)|Lung NSC(13;0.0384)|Breast(268;0.174)													HNSCC(25;0.065)			---	---	---	---
LPCAT2	54947	broad.mit.edu	37	16	55613109	55613109	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:55613109T>G	uc002eie.3	+	13	1584	c.1403T>G	c.(1402-1404)GTT>GGT	p.V468G	LPCAT2_uc002eic.2_Missense_Mutation_p.V198G	NM_017839	NP_060309	Q7L5N7	PCAT2_HUMAN	lysophosphatidylcholine acyltransferase 2	468	Lumenal (Potential).				cellular membrane organization|platelet activating factor biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|Golgi stack|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding				0																		---	---	---	---
GPR114	221188	broad.mit.edu	37	16	57597818	57597818	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:57597818G>A	uc002elx.3	+	5	441	c.356G>A	c.(355-357)CGG>CAG	p.R119Q	GPR114_uc010vhr.1_Missense_Mutation_p.R119Q|GPR114_uc002ely.2_Missense_Mutation_p.R119Q	NM_153837	NP_722579	Q8IZF4	GP114_HUMAN	G protein-coupled receptor 114 precursor	119	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)	1																		---	---	---	---
TK2	7084	broad.mit.edu	37	16	66565325	66565325	+	Silent	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:66565325A>C	uc002eos.2	-	5	684	c.459T>G	c.(457-459)ACT>ACG	p.T153T	TK2_uc010vip.1_Silent_p.T14T|TK2_uc002eor.2_Silent_p.T80T|TK2_uc010cdq.2_Silent_p.T80T|TK2_uc010cdr.2_Silent_p.T62T|TK2_uc010viq.1_Silent_p.T135T|TK2_uc010vir.1_Silent_p.T128T	NM_004614	NP_004605	O00142	KITM_HUMAN	thymidine kinase 2, mitochondrial	111					pyrimidine base metabolic process|pyrimidine nucleoside salvage	mitochondrial matrix	ATP binding|phosphotransferase activity, alcohol group as acceptor|thymidine kinase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0736)|Epithelial(162;0.237)														---	---	---	---
MTSS1L	92154	broad.mit.edu	37	16	70710872	70710872	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:70710872C>T	uc002ezj.2	-	10	1002	c.742G>A	c.(742-744)GAC>AAC	p.D248N	MTSS1L_uc002ezk.1_Missense_Mutation_p.D165N	NM_138383	NP_612392	Q765P7	MTSSL_HUMAN	metastasis suppressor 1-like	248	IMD.				filopodium assembly|signal transduction		actin binding|cytoskeletal adaptor activity|SH3 domain binding			central_nervous_system(1)	1																		---	---	---	---
CTU2	348180	broad.mit.edu	37	16	88779164	88779164	+	Silent	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:88779164G>A	uc002flm.2	+	7	636	c.588G>A	c.(586-588)CCG>CCA	p.P196P	CTU2_uc002fln.2_Silent_p.P196P|CTU2_uc010chz.2_Silent_p.P267P|CTU2_uc010cia.2_Silent_p.P109P	NM_001012759	NP_001012777	Q2VPK5	CTU2_HUMAN	cytoplasmic tRNA 2-thiolation protein 2 isoform	196					tRNA thio-modification|tRNA wobble uridine modification	cytoplasm|protein complex|soluble fraction	protein binding			skin(1)	1																		---	---	---	---
FAM101B	359845	broad.mit.edu	37	17	293034	293034	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:293034G>A	uc002frj.2	-	2	630	c.356C>T	c.(355-357)ACG>ATG	p.T119M		NM_182705	NP_874364	Q8N5W9	F101B_HUMAN	hypothetical protein LOC359845	189											0		Myeloproliferative disorder(207;0.204)		UCEC - Uterine corpus endometrioid carcinoma (25;0.0216)														---	---	---	---
PER1	5187	broad.mit.edu	37	17	8047060	8047060	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:8047060T>G	uc002gkd.2	-	19	2834	c.2596A>C	c.(2596-2598)ACC>CCC	p.T866P	PER1_uc010cns.2_5'Flank|PER1_uc010vuq.1_Intron	NM_002616	NP_002607	O15534	PER1_HUMAN	period 1	866	Pro-rich.				circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			lung(2)|breast(2)|skin(2)|large_intestine(1)|ovary(1)|kidney(1)	9								T	ETV6	AML|CMML			Other_conserved_DNA_damage_response_genes					---	---	---	---
ABCA6	23460	broad.mit.edu	37	17	67087355	67087355	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:67087355T>C	uc002jhw.1	-	26	3632	c.3457A>G	c.(3457-3459)AGT>GGT	p.S1153G		NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	1153	Helical; (Potential).				transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)																	---	---	---	---
AZI1	22994	broad.mit.edu	37	17	79167799	79167799	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:79167799C>T	uc002jzp.1	-	18	2457	c.2257G>A	c.(2257-2259)GAG>AAG	p.E753K	AZI1_uc002jzm.1_Missense_Mutation_p.E180K|AZI1_uc002jzn.1_Missense_Mutation_p.E750K|AZI1_uc002jzo.1_Missense_Mutation_p.E750K|AZI1_uc010wum.1_Missense_Mutation_p.E753K|AZI1_uc002jzq.2_5'UTR	NM_014984	NP_055799	Q9UPN4	AZI1_HUMAN	5-azacytidine induced 1 isoform a	753					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centrosome|cytosol|intracellular membrane-bounded organelle				central_nervous_system(2)|large_intestine(1)|ovary(1)	4	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)															---	---	---	---
SLC16A3	9123	broad.mit.edu	37	17	80195380	80195380	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:80195380C>A	uc002kea.2	+	4	873	c.734C>A	c.(733-735)CCG>CAG	p.P245Q	SLC16A3_uc002kee.2_Missense_Mutation_p.P245Q|SLC16A3_uc002keb.2_Missense_Mutation_p.P245Q|SLC16A3_uc002kec.2_Missense_Mutation_p.P245Q|SLC16A3_uc002ked.2_Missense_Mutation_p.P245Q	NM_001042422	NP_001035887	O15427	MOT4_HUMAN	solute carrier family 16, member 3	245	Helical; (Potential).				blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	actin cytoskeleton|integral to plasma membrane|membrane fraction|nuclear membrane	secondary active monocarboxylate transmembrane transporter activity|symporter activity			upper_aerodigestive_tract(1)|lung(1)	2	Breast(20;0.00285)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.227)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0149)		Pyruvic acid(DB00119)													---	---	---	---
ZNF750	79755	broad.mit.edu	37	17	80788291	80788291	+	Silent	SNP	C	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:80788291C>A	uc002kga.2	-	3	2210	c.1899G>T	c.(1897-1899)ACG>ACT	p.T633T	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	633						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)															---	---	---	---
C18orf8	29919	broad.mit.edu	37	18	21086966	21086966	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:21086966A>C	uc010xax.1	+	3	333	c.212A>C	c.(211-213)AAG>ACG	p.K71T	C18orf8_uc010xau.1_Intron|C18orf8_uc010xav.1_Missense_Mutation_p.K71T|C18orf8_uc010xaw.1_Intron|C18orf8_uc002kul.2_RNA	NM_013326	NP_037458	Q96DM3	MIC1_HUMAN	colon cancer-associated protein Mic1	71										ovary(1)	1	all_cancers(21;0.000122)|all_epithelial(16;8.08e-07)|Lung NSC(20;0.00206)|all_lung(20;0.00659)|Colorectal(14;0.0202)|Ovarian(20;0.127)																	---	---	---	---
ZNF521	25925	broad.mit.edu	37	18	22807019	22807019	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:22807019T>C	uc002kvk.2	-	4	1110	c.863A>G	c.(862-864)GAG>GGG	p.E288G	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.E288G|ZNF521_uc002kvl.2_Missense_Mutation_p.E68G	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	288	C2H2-type 7.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)							T	PAX5	ALL								---	---	---	---
PIK3C3	5289	broad.mit.edu	37	18	39647433	39647433	+	Missense_Mutation	SNP	G	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:39647433G>C	uc002lap.2	+	24	2663	c.2605G>C	c.(2605-2607)GCT>CCT	p.A869P	PIK3C3_uc010xcl.1_Missense_Mutation_p.A806P|PIK3C3_uc002laq.2_Missense_Mutation_p.A354P	NM_002647	NP_002638	Q8NEB9	PK3C3_HUMAN	catalytic phosphatidylinositol 3-kinase 3	869	PI3K/PI4K.				cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			lung(8)|ovary(1)|breast(1)	10															TSP Lung(28;0.18)			---	---	---	---
TCEB3B	51224	broad.mit.edu	37	18	44560668	44560668	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:44560668C>A	uc002lcr.1	-	1	1321	c.968G>T	c.(967-969)CGG>CTG	p.R323L	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	323					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4																		---	---	---	---
DCC	1630	broad.mit.edu	37	18	50731590	50731590	+	Silent	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:50731590A>G	uc002lfe.1	+	10	2165	c.1578A>G	c.(1576-1578)CAA>CAG	p.Q526Q	DCC_uc010xdr.1_Silent_p.Q374Q|DCC_uc010dpf.1_Silent_p.Q181Q	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	526	Extracellular (Potential).				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)														---	---	---	---
RAX	30062	broad.mit.edu	37	18	56936342	56936342	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:56936342T>G	uc002lhx.2	-	3	1122	c.935A>C	c.(934-936)AAG>ACG	p.K312T	RAX_uc010dpp.2_3'UTR	NM_013435	NP_038463	Q9Y2V3	RX_HUMAN	retina and anterior neural fold homeobox	312					visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1		Lung NSC(161;0.0804)|Colorectal(73;0.0946)		STAD - Stomach adenocarcinoma(84;0.18)														---	---	---	---
RTTN	25914	broad.mit.edu	37	18	67684867	67684867	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:67684867C>T	uc002lkp.2	-	46	6265	c.6197G>A	c.(6196-6198)GGA>GAA	p.G2066E	RTTN_uc002lko.2_RNA|RTTN_uc010xfb.1_Missense_Mutation_p.G1154E|RTTN_uc002lkn.2_Missense_Mutation_p.G56E|RTTN_uc010dqp.2_Missense_Mutation_p.G318E	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	2066							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)																---	---	---	---
APC2	10297	broad.mit.edu	37	19	1465645	1465645	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:1465645A>G	uc002lsr.1	+	15	2553	c.2345A>G	c.(2344-2346)GAT>GGT	p.D782G	APC2_uc002lss.1_Missense_Mutation_p.D364G|APC2_uc002lst.1_Missense_Mutation_p.D782G|APC2_uc002lsu.1_Missense_Mutation_p.D781G|C19orf25_uc010xgn.1_Intron	NM_005883	NP_005874	O95996	APC2_HUMAN	adenomatosis polyposis coli 2	782					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|pancreas(1)	4		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
DOT1L	84444	broad.mit.edu	37	19	2226981	2226981	+	Silent	SNP	C	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:2226981C>A	uc002lvb.3	+	27	4497	c.4461C>A	c.(4459-4461)TCC>TCA	p.S1487S	DOT1L_uc002lvc.1_Silent_p.S781S	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	1487						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
FZR1	51343	broad.mit.edu	37	19	3526252	3526252	+	Intron	SNP	C	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:3526252C>A	uc010dtk.2	+						FZR1_uc002lxt.2_Intron|FZR1_uc002lxv.2_Intron	NM_001136198	NP_001129670			Fzr1 protein isoform 1						activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|DNA repair|G2/M transition DNA damage checkpoint|mitosis|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding			lung(1)|kidney(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
ARRDC5	645432	broad.mit.edu	37	19	4891231	4891231	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4891231C>T	uc002mbm.2	-	3	856	c.856G>A	c.(856-858)GGT>AGT	p.G286S		NM_001080523	NP_001073992	A6NEK1	ARRD5_HUMAN	arrestin domain containing 5	286					signal transduction						0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0257)														---	---	---	---
DENND1C	79958	broad.mit.edu	37	19	6481686	6481686	+	Intron	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6481686T>G	uc002mfe.2	-						DENND1C_uc002mfd.2_5'Flank|DENND1C_uc010xje.1_Intron	NM_024898	NP_079174			DENN/MADD domain containing 1C							clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			large_intestine(1)	1																		---	---	---	---
MUC16	94025	broad.mit.edu	37	19	9018538	9018538	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9018538A>C	uc002mkp.2	-	24	37840	c.37636T>G	c.(37636-37638)TTC>GTC	p.F12546V		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12548	SEA 4.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57																		---	---	---	---
OR7G1	125962	broad.mit.edu	37	19	9226256	9226256	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9226256G>T	uc002mks.1	-	1	184	c.184C>A	c.(184-186)CTT>ATT	p.L62I		NM_001005192	NP_001005192	Q8NGA0	OR7G1_HUMAN	olfactory receptor, family 7, subfamily G,	62	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2																		---	---	---	---
ZNF559	84527	broad.mit.edu	37	19	9453044	9453044	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9453044T>G	uc002mlg.2	+	7	1564	c.917T>G	c.(916-918)TTT>TGT	p.F306C	ZNF559_uc002mlf.2_Missense_Mutation_p.F75C|ZNF559_uc010dwl.1_Missense_Mutation_p.F75C|ZNF559_uc010xkn.1_Missense_Mutation_p.F298C|ZNF559_uc010dwm.1_3'UTR|ZNF559_uc002mle.3_Missense_Mutation_p.F370C|ZNF559_uc010dwk.1_Missense_Mutation_p.F75C|ZNF559_uc002mld.2_3'UTR|ZNF559_uc010dwo.1_Intron|ZNF177_uc002mli.2_Intron|ZNF177_uc002mlj.2_Intron	NM_032497	NP_115886	Q9BR84	ZN559_HUMAN	zinc finger protein 559	306	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1																		---	---	---	---
TRMT1	55621	broad.mit.edu	37	19	13226979	13226979	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:13226979C>T	uc002mwj.2	-	1	485	c.235G>A	c.(235-237)GAA>AAA	p.E79K	NACC1_uc002mwm.2_5'Flank|TRMT1_uc002mwk.2_Missense_Mutation_p.E79K|TRMT1_uc002mwl.3_Missense_Mutation_p.E79K|TRMT1_uc010xmz.1_Intron	NM_017722	NP_060192	Q9NXH9	TRM1_HUMAN	tRNA methyltransferase 1 isoform 1	79							RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(19;6.08e-22)	GBM - Glioblastoma multiforme(1328;0.0356)														---	---	---	---
SLC1A6	6511	broad.mit.edu	37	19	15079169	15079169	+	Missense_Mutation	SNP	C	T	T	rs149934975		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:15079169C>T	uc002naa.1	-	3	502	c.494G>A	c.(493-495)CGG>CAG	p.R165Q	SLC1A6_uc010dzu.1_Missense_Mutation_p.R165Q|SLC1A6_uc010xod.1_Intron|SLC1A6_uc002nab.2_Missense_Mutation_p.R165Q|SLC1A6_uc002nac.2_Missense_Mutation_p.R165Q|SLC1A6_uc002nad.1_Missense_Mutation_p.R165Q	NM_005071	NP_005062	P48664	EAA4_HUMAN	solute carrier family 1 (high affinity	165	Extracellular (Potential).				synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			pancreas(3)|ovary(2)|skin(1)	6					L-Glutamic Acid(DB00142)													---	---	---	---
CYP4F2	8529	broad.mit.edu	37	19	15989663	15989663	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:15989663T>G	uc002nbs.1	-	13	1531	c.1481A>C	c.(1480-1482)GAC>GCC	p.D494A	CYP4F2_uc010xot.1_Missense_Mutation_p.D345A	NM_001082	NP_001073	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F,	494					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			ovary(1)|skin(1)	2																		---	---	---	---
JAK3	3718	broad.mit.edu	37	19	17951088	17951088	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17951088C>T	uc002nhn.3	-	9	1305	c.1205G>A	c.(1204-1206)CGC>CAC	p.R402H	JAK3_uc010ebh.2_RNA|JAK3_uc002nho.2_Missense_Mutation_p.R402H|JAK3_uc010xpx.1_Missense_Mutation_p.R402H	NM_000215	NP_000206	P52333	JAK3_HUMAN	Janus kinase 3	402	SH2; atypical.				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			haematopoietic_and_lymphoid_tissue(40)|lung(5)|breast(5)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	56							2	Mis		acute megakaryocytic leukemia|								---	---	---	---
ISYNA1	51477	broad.mit.edu	37	19	18547246	18547246	+	Missense_Mutation	SNP	G	A	A	rs138096546		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:18547246G>A	uc002njd.1	-	6	703	c.653C>T	c.(652-654)GCG>GTG	p.A218V	ISYNA1_uc002nja.1_Missense_Mutation_p.A90V|ISYNA1_uc002njb.1_Missense_Mutation_p.A136V|ISYNA1_uc002njc.1_Missense_Mutation_p.A68V|ISYNA1_uc010xqh.1_Missense_Mutation_p.A16V|ISYNA1_uc002nje.1_Missense_Mutation_p.A164V|ISYNA1_uc002njf.1_Missense_Mutation_p.A68V	NM_016368	NP_057452	Q9NPH2	INO1_HUMAN	inositol-3-phosphate synthase 1	218					inositol biosynthetic process|phospholipid biosynthetic process	cytoplasm	binding|inositol-3-phosphate synthase activity			ovary(1)|pancreas(1)	2																		---	---	---	---
ZNF536	9745	broad.mit.edu	37	19	31040061	31040061	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:31040061G>T	uc002nsu.1	+	4	3673	c.3535G>T	c.(3535-3537)GAT>TAT	p.D1179Y	ZNF536_uc010edd.1_Missense_Mutation_p.D1179Y	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1179					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)																	---	---	---	---
SPINT2	10653	broad.mit.edu	37	19	38779813	38779813	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:38779813G>A	uc002ohr.1	+	4	704	c.373G>A	c.(373-375)GAT>AAT	p.D125N	SPINT2_uc002ohs.1_Missense_Mutation_p.D68N	NM_021102	NP_066925	O43291	SPIT2_HUMAN	serine protease inhibitor, Kunitz type, 2	125	Extracellular (Potential).				cellular component movement	cytoplasm|extracellular region|integral to membrane|soluble fraction	serine-type endopeptidase inhibitor activity				0	all_cancers(60;6.83e-07)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)															---	---	---	---
ATP1A3	478	broad.mit.edu	37	19	42479939	42479939	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42479939A>G	uc002osg.2	-	16	2259	c.2105T>C	c.(2104-2106)GTG>GCG	p.V702A	ATP1A3_uc010xwf.1_Missense_Mutation_p.V713A|ATP1A3_uc010xwg.1_Missense_Mutation_p.V672A|ATP1A3_uc010xwh.1_Missense_Mutation_p.V715A|ATP1A3_uc002osh.2_Missense_Mutation_p.V702A	NM_152296	NP_689509	P13637	AT1A3_HUMAN	Na+/K+ -ATPase alpha 3 subunit	702	Cytoplasmic (Potential).				ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(1)|pancreas(1)	2																		---	---	---	---
TRPM4	54795	broad.mit.edu	37	19	49705384	49705384	+	Silent	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49705384C>T	uc002pmw.2	+	20	3189	c.3117C>T	c.(3115-3117)CTC>CTT	p.L1039L	TRPM4_uc010emu.2_Silent_p.L894L|TRPM4_uc010yak.1_Silent_p.L503L|TRPM4_uc002pmx.2_Silent_p.L865L|TRPM4_uc010emv.2_Silent_p.L924L|TRPM4_uc010yal.1_Silent_p.L685L|TRPM4_uc002pmy.2_Silent_p.L381L	NM_017636	NP_060106	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel,	1039	Helical; (Potential).				dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			ovary(1)|central_nervous_system(1)	2		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)														---	---	---	---
PTH2	113091	broad.mit.edu	37	19	49926533	49926533	+	Missense_Mutation	SNP	G	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49926533G>C	uc002pnn.1	-	1	166	c.64C>G	c.(64-66)CTG>GTG	p.L22V		NM_178449	NP_848544	Q96A98	TIP39_HUMAN	parathyroid hormone 2 preproprotein	22					neuropeptide signaling pathway	extracellular region					0				OV - Ovarian serous cystadenocarcinoma(262;0.0015)|GBM - Glioblastoma multiforme(486;0.044)|Lung(386;0.0785)|LUSC - Lung squamous cell carcinoma(496;0.0836)														---	---	---	---
POLD1	5424	broad.mit.edu	37	19	50910659	50910659	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50910659G>A	uc002psb.3	+	14	1818	c.1762G>A	c.(1762-1764)GAG>AAG	p.E588K	POLD1_uc002psc.3_Missense_Mutation_p.E588K|POLD1_uc010enx.2_RNA|POLD1_uc010eny.2_Missense_Mutation_p.E588K	NM_002691	NP_002682	P28340	DPOD1_HUMAN	DNA-directed DNA polymerase delta 1	588					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|response to UV|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm|nucleotide-excision repair complex	3'-5'-exodeoxyribonuclease activity|chromatin binding|DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding|protein binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2		all_neural(266;0.0571)		OV - Ovarian serous cystadenocarcinoma(262;0.00794)|GBM - Glioblastoma multiforme(134;0.0195)									DNA_polymerases_(catalytic_subunits)					---	---	---	---
ZNF610	162963	broad.mit.edu	37	19	52857592	52857592	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:52857592A>C	uc002pyx.3	+	5	685	c.279A>C	c.(277-279)AAA>AAC	p.K93N	ZNF610_uc002pyy.3_Missense_Mutation_p.K93N|ZNF610_uc002pyz.3_Intron|ZNF610_uc002pza.2_Missense_Mutation_p.K93N	NM_001161426	NP_001154898	Q8N9Z0	ZN610_HUMAN	zinc finger protein 610 isoform a	93	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3				OV - Ovarian serous cystadenocarcinoma(262;0.00396)|GBM - Glioblastoma multiforme(134;0.00434)														---	---	---	---
ZNF347	84671	broad.mit.edu	37	19	53645784	53645784	+	Missense_Mutation	SNP	T	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:53645784T>A	uc002qbb.1	-	5	366	c.297A>T	c.(295-297)AAA>AAT	p.K99N	ZNF347_uc010eql.1_Missense_Mutation_p.K100N|ZNF347_uc002qbc.1_Missense_Mutation_p.K100N	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	99					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)														---	---	---	---
KIR2DL1	3802	broad.mit.edu	37	19	55284967	55284967	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55284967T>G	uc002qhb.1	+	3	291	c.253T>G	c.(253-255)TTC>GTC	p.F85V	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR2DL3_uc010erw.1_Intron|KIR2DL1_uc002qgz.1_Intron|KIR2DL3_uc002qha.1_Intron|KIR3DP1_uc010yfi.1_Intron|KIR2DL1_uc010erz.1_Missense_Mutation_p.F85V	NM_014218	NP_055033	P43626	KI2L1_HUMAN	killer cell immunoglobulin-like receptor, two	85	Extracellular (Potential).|Ig-like C2-type 1.				immune response|natural killer cell inhibitory signaling pathway	integral to plasma membrane	protein binding|receptor activity				0				GBM - Glioblastoma multiforme(193;0.0192)														---	---	---	---
NLRP9	338321	broad.mit.edu	37	19	56243496	56243496	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:56243496T>G	uc002qly.2	-	2	1729	c.1701A>C	c.(1699-1701)GAA>GAC	p.E567D		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	567						cytoplasm	ATP binding			skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)														---	---	---	---
DEFB132	400830	broad.mit.edu	37	20	238424	238424	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:238424A>G	uc002wdb.2	+	1	48	c.5A>G	c.(4-6)AAG>AGG	p.K2R		NM_207469	NP_997352	Q7Z7B7	DB132_HUMAN	beta-defensin 32 precursor	2					defense response to bacterium	extracellular region					0																		---	---	---	---
RBCK1	10616	broad.mit.edu	37	20	402813	402813	+	Silent	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:402813G>A	uc002wdp.3	+	8	1653	c.960G>A	c.(958-960)GAG>GAA	p.E320E	RBCK1_uc010zpm.1_RNA|RBCK1_uc002wdq.3_Silent_p.E278E|RBCK1_uc010fzy.2_RNA|RBCK1_uc002wdr.3_Silent_p.E150E	NM_031229	NP_112506	Q9BYM8	HOIL1_HUMAN	RanBP-type and C3HC4-type zinc finger containing	320	RING-type.				interspecies interaction between organisms|negative regulation of NF-kappaB transcription factor activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|proteasomal ubiquitin-dependent protein catabolic process|protein linear polyubiquitination|T cell receptor signaling pathway	LUBAC complex	protein binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0		all_epithelial(17;0.172)|Lung NSC(37;0.191)|Breast(17;0.231)																---	---	---	---
ZNF343	79175	broad.mit.edu	37	20	2463798	2463798	+	3'UTR	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:2463798T>C	uc002wge.1	-	6					ZNF343_uc010gao.1_3'UTR|ZNF343_uc002wgd.1_3'UTR	NM_024325	NP_077301			zinc finger protein 343						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3																		---	---	---	---
PAX1	5075	broad.mit.edu	37	20	21695269	21695269	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:21695269C>T	uc002wsj.2	+	5	1487	c.1433C>T	c.(1432-1434)GCG>GTG	p.A478V	PAX1_uc010zsl.1_3'UTR|PAX1_uc010zsm.1_3'UTR	NM_006192	NP_006183	P15863	PAX1_HUMAN	paired box 1	478					regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			upper_aerodigestive_tract(1)|kidney(1)	2																		---	---	---	---
SSTR4	6754	broad.mit.edu	37	20	23016968	23016968	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:23016968T>G	uc002wsr.2	+	1	912	c.848T>G	c.(847-849)CTC>CGC	p.L283R		NM_001052	NP_001043	P31391	SSR4_HUMAN	somatostatin receptor 4	283	Extracellular (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			ovary(1)	1	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)																	---	---	---	---
CD93	22918	broad.mit.edu	37	20	23064893	23064893	+	Intron	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:23064893T>C	uc002wsv.2	-							NM_012072	NP_036204			CD93 antigen precursor						cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			large_intestine(2)	2	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)																	---	---	---	---
NAPB	63908	broad.mit.edu	37	20	23383641	23383641	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:23383641T>C	uc002wta.2	-	2	284	c.167A>G	c.(166-168)AAA>AGA	p.K56R	NAPB_uc002wtc.2_5'UTR|NAPB_uc002wtb.2_Missense_Mutation_p.K56R|NAPB_uc002wtd.3_RNA|NAPB_uc010zst.1_Missense_Mutation_p.K56R	NM_022080	NP_071363	Q9H115	SNAB_HUMAN	N-ethylmaleimide-sensitive factor attachment	56					intracellular protein transport|vesicle-mediated transport	membrane				ovary(1)	1	Lung NSC(19;0.0646)|Colorectal(13;0.0993)|all_lung(19;0.143)																	---	---	---	---
NINL	22981	broad.mit.edu	37	20	25462679	25462679	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:25462679G>T	uc002wux.1	-	14	1809	c.1735C>A	c.(1735-1737)CTG>ATG	p.L579M	NINL_uc010gdn.1_Missense_Mutation_p.L579M|NINL_uc010gdo.1_Missense_Mutation_p.L362M	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	579	Potential.				G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5																		---	---	---	---
VSTM2L	128434	broad.mit.edu	37	20	36572448	36572448	+	Silent	SNP	C	T	T	rs150645578		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:36572448C>T	uc002xhk.3	+	4	662	c.408C>T	c.(406-408)GAC>GAT	p.D136D		NM_080607	NP_542174	Q96N03	VTM2L_HUMAN	V-set and transmembrane domain containing 2 like	136	Ig-like.									ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(115;0.00878)																---	---	---	---
PREX1	57580	broad.mit.edu	37	20	47267989	47267989	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:47267989C>A	uc002xtw.1	-	22	2623	c.2600G>T	c.(2599-2601)TGC>TTC	p.C867F	PREX1_uc002xtv.1_Missense_Mutation_p.C164F	NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	867					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)															---	---	---	---
SALL4	57167	broad.mit.edu	37	20	50406626	50406626	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:50406626T>C	uc002xwh.3	-	2	2497	c.2396A>G	c.(2395-2397)AAG>AGG	p.K799R	SALL4_uc010gii.2_Intron|SALL4_uc002xwi.3_Intron	NM_020436	NP_065169	Q9UJQ4	SALL4_HUMAN	sal-like 4	799					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2																		---	---	---	---
CASS4	57091	broad.mit.edu	37	20	55027707	55027707	+	Missense_Mutation	SNP	A	T	T	rs145762733		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:55027707A>T	uc002xxp.2	+	6	1700	c.1475A>T	c.(1474-1476)GAA>GTA	p.E492V	CASS4_uc002xxq.3_Missense_Mutation_p.E492V|CASS4_uc002xxr.2_Missense_Mutation_p.E492V|CASS4_uc010zze.1_Missense_Mutation_p.E438V|CASS4_uc010gio.2_Intron	NM_001164116	NP_001157588	Q9NQ75	CASS4_HUMAN	HEF-like protein isoform a	492					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			ovary(2)|skin(1)	3																		---	---	---	---
CDH26	60437	broad.mit.edu	37	20	58564160	58564160	+	Missense_Mutation	SNP	G	T	T	rs143325825		TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:58564160G>T	uc002ybe.2	+	9	1525	c.1225G>T	c.(1225-1227)GCC>TCC	p.A409S	CDH26_uc002ybf.1_5'UTR|CDH26_uc010zzy.1_RNA	NM_177980	NP_817089	Q8IXH8	CAD26_HUMAN	cadherin-like 26 isoform a	409	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|central_nervous_system(1)	4	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)															---	---	---	---
PRPF6	24148	broad.mit.edu	37	20	62658332	62658332	+	Intron	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:62658332C>T	uc002yho.2	+						PRPF6_uc002yhp.2_Intron	NM_012469	NP_036601			PRP6 pre-mRNA processing factor 6 homolog						assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			ovary(2)	2	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)																	---	---	---	---
LIPI	149998	broad.mit.edu	37	21	15561478	15561478	+	Silent	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:15561478T>C	uc002yjm.2	-	2	382	c.372A>G	c.(370-372)GAA>GAG	p.E124E	LIPI_uc010gkw.1_Silent_p.E57E	NM_198996	NP_945347	Q6XZB0	LIPI_HUMAN	lipase, member I	103					lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			ovary(2)	2				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)														---	---	---	---
ADAMTS5	11096	broad.mit.edu	37	21	28296442	28296442	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:28296442T>G	uc002ymg.2	-	8	3452	c.2723A>C	c.(2722-2724)AAG>ACG	p.K908T		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	908	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4																		---	---	---	---
TIAM1	7074	broad.mit.edu	37	21	32638350	32638350	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:32638350T>G	uc002yow.1	-	5	1411	c.939A>C	c.(937-939)CAA>CAC	p.Q313H	TIAM1_uc011adk.1_Missense_Mutation_p.Q313H|TIAM1_uc011adl.1_Missense_Mutation_p.Q313H|TIAM1_uc002yox.1_Intron	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	313					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10																		---	---	---	---
HUNK	30811	broad.mit.edu	37	21	33371499	33371499	+	3'UTR	SNP	T	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:33371499T>A	uc002yph.2	+	11						NM_014586	NP_055401			hormonally upregulated Neu-associated kinase						multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			stomach(1)|skin(1)	2																		---	---	---	---
CECR1	51816	broad.mit.edu	37	22	17688091	17688091	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:17688091A>C	uc002zmk.1	-	2	624	c.412T>G	c.(412-414)TTC>GTC	p.F138V	CECR1_uc010gqu.1_Missense_Mutation_p.F138V|CECR1_uc011agi.1_Missense_Mutation_p.F96V|CECR1_uc011agj.1_Missense_Mutation_p.F96V	NM_017424	NP_059120	Q9NZK5	CECR1_HUMAN	cat eye syndrome critical region protein 1	138	PRB domain.				adenosine catabolic process|hypoxanthine salvage|inosine biosynthetic process|multicellular organismal development|purine ribonucleoside monophosphate biosynthetic process	extracellular space|Golgi apparatus	adenosine deaminase activity|adenosine receptor binding|growth factor activity|heparin binding|protein homodimerization activity|proteoglycan binding|zinc ion binding			ovary(1)	1		all_epithelial(15;0.0152)|Lung NSC(13;0.0875)|all_lung(157;0.106)																---	---	---	---
GNAZ	2781	broad.mit.edu	37	22	23437912	23437912	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:23437912A>C	uc002zwu.1	+	2	567	c.30A>C	c.(28-30)AAA>AAC	p.K10N	RTDR1_uc002zwt.2_Intron	NM_002073	NP_002064	P19086	GNAZ_HUMAN	guanine nucleotide binding protein, alpha z	10						endoplasmic reticulum|heterotrimeric G-protein complex|nuclear envelope	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|metabotropic serotonin receptor binding|receptor signaling protein activity			kidney(1)|skin(1)	2	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.166)														---	---	---	---
ZNRF3	84133	broad.mit.edu	37	22	29445296	29445296	+	Missense_Mutation	SNP	A	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:29445296A>T	uc003aeg.2	+	8	992	c.827A>T	c.(826-828)AAC>ATC	p.N276I	ZNRF3_uc003aeh.1_Missense_Mutation_p.N276I	NM_032173	NP_115549	Q9ULT6	ZNRF3_HUMAN	zinc and ring finger 3	376	Cytoplasmic (Potential).					integral to membrane	zinc ion binding			ovary(1)	1																		---	---	---	---
EFCAB6	64800	broad.mit.edu	37	22	44063009	44063009	+	Missense_Mutation	SNP	T	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:44063009T>A	uc003bdy.1	-	17	2173	c.1958A>T	c.(1957-1959)AAA>ATA	p.K653I	EFCAB6_uc003bdz.1_Missense_Mutation_p.K501I|EFCAB6_uc010gzi.1_Missense_Mutation_p.K501I|EFCAB6_uc010gzj.1_5'UTR|EFCAB6_uc010gzk.1_RNA	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	653	EF-hand 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)																---	---	---	---
PKDREJ	10343	broad.mit.edu	37	22	46655349	46655349	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:46655349C>T	uc003bhh.2	-	1	3871	c.3871G>A	c.(3871-3873)GGG>AGG	p.G1291R		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1291	Cytoplasmic (Potential).|PLAT.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)														---	---	---	---
STS	412	broad.mit.edu	37	X	7268091	7268091	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:7268091C>A	uc004cry.3	+	10	1786	c.1541C>A	c.(1540-1542)CCA>CAA	p.P514Q		NM_000351	NP_000342	P08842	STS_HUMAN	steryl-sulfatase precursor	514	Lumenal.				female pregnancy|steroid catabolic process	endoplasmic reticulum membrane|endosome|Golgi apparatus|integral to membrane|lysosome|microsome|plasma membrane	metal ion binding|steryl-sulfatase activity			central_nervous_system(1)	1		Colorectal(8;0.0136)|Medulloblastoma(8;0.184)			Estrone(DB00655)									Ichthyosis				---	---	---	---
WWC3	55841	broad.mit.edu	37	X	10047829	10047829	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:10047829T>C	uc004csx.3	+	5	560	c.362T>C	c.(361-363)GTG>GCG	p.V121A	WWC3_uc010nds.2_5'UTR|WWC3_uc010ndt.2_RNA	NM_015691	NP_056506	Q9ULE0	WWC3_HUMAN	WWC family member 3	121	Potential.									ovary(4)	4																		---	---	---	---
REPS2	9185	broad.mit.edu	37	X	17080602	17080602	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:17080602T>C	uc004cxv.1	+	9	1327	c.1156T>C	c.(1156-1158)TAT>CAT	p.Y386H	REPS2_uc004cxw.1_Missense_Mutation_p.Y385H|REPS2_uc011miw.1_Missense_Mutation_p.Y245H	NM_004726	NP_004717	Q8NFH8	REPS2_HUMAN	RALBP1 associated Eps domain containing 2	386					epidermal growth factor receptor signaling pathway|protein complex assembly	cytoplasm	calcium ion binding|protein binding			skin(2)|central_nervous_system(1)	3	Hepatocellular(33;0.183)																	---	---	---	---
MAOB	4129	broad.mit.edu	37	X	43662581	43662581	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:43662581T>G	uc004dfz.3	-	4	526	c.350A>C	c.(349-351)AAC>ACC	p.N117T	MAOB_uc011mkx.1_Missense_Mutation_p.N101T|MAOB_uc011mky.1_Missense_Mutation_p.N101T	NM_000898	NP_000889	P27338	AOFB_HUMAN	monoamine oxidase B	117	Cytoplasmic.				xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	electron carrier activity|primary amine oxidase activity			ovary(1)|central_nervous_system(1)	2					Amantadine(DB00915)|Bupropion(DB01156)|Carbidopa(DB00190)|Citalopram(DB00215)|Dopamine(DB00988)|Entacapone(DB00494)|Furazolidone(DB00614)|Ginkgo biloba(DB01381)|Ibuprofen(DB01050)|Imipramine(DB00458)|Iproniazid(DB04818)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Maprotiline(DB00934)|Meclizine(DB00737)|Moclobemide(DB01171)|Nicotine(DB00184)|Pargyline(DB01626)|Phenelzine(DB00780)|Phentermine(DB00191)|Rasagiline(DB01367)|Selegiline(DB01037)|Tranylcypromine(DB00752)													---	---	---	---
ZNF630	57232	broad.mit.edu	37	X	47918755	47918755	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:47918755T>G	uc004div.3	-	5	1328	c.1076A>C	c.(1075-1077)AAG>ACG	p.K359T	ZNF630_uc010nhz.1_Intron|ZNF630_uc004diw.2_Missense_Mutation_p.K235T	NM_001037735	NP_001032824	Q2M218	ZN630_HUMAN	zinc finger protein 630	359	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|lung(1)	2																		---	---	---	---
KIAA2022	340533	broad.mit.edu	37	X	73961294	73961294	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:73961294T>G	uc004eby.2	-	3	3715	c.3098A>C	c.(3097-3099)AAG>ACG	p.K1033T		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	1033					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15																		---	---	---	---
BTK	695	broad.mit.edu	37	X	100630128	100630128	+	Intron	SNP	T	G	G			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:100630128T>G	uc004ehg.2	-						BTK_uc010nnn.2_Intron|BTK_uc010nno.2_Intron|BTK_uc004ehi.2_Intron	NM_000061	NP_000052			Bruton agammaglobulinemia tyrosine kinase						calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding			lung(3)|central_nervous_system(2)|ovary(1)	6														Agammaglobulinemia_X-linked				---	---	---	---
TRPC5	7224	broad.mit.edu	37	X	111022219	111022219	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:111022219A>C	uc004epl.1	-	10	3145	c.2226T>G	c.(2224-2226)AAT>AAG	p.N742K		NM_012471	NP_036603	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel,	742	Cytoplasmic (Potential).				axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			urinary_tract(1)	1																		---	---	---	---
USP26	83844	broad.mit.edu	37	X	132160633	132160633	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:132160633A>C	uc010nrm.1	-	6	2086	c.1616T>G	c.(1615-1617)GTC>GGC	p.V539G	USP26_uc011mvf.1_Missense_Mutation_p.V539G	NM_031907	NP_114113	Q9BXU7	UBP26_HUMAN	ubiquitin-specific protease 26	539					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(3)|central_nervous_system(3)|kidney(1)|liver(1)	8	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
ARHGEF6	9459	broad.mit.edu	37	X	135825841	135825841	+	Silent	SNP	G	A	A			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:135825841G>A	uc004fab.2	-	5	1026	c.564C>T	c.(562-564)TAC>TAT	p.Y188Y	ARHGEF6_uc011mwd.1_Silent_p.Y34Y|ARHGEF6_uc011mwe.1_Silent_p.Y34Y	NM_004840	NP_004831	Q15052	ARHG6_HUMAN	Rac/Cdc42 guanine nucleotide exchange factor 6	188	SH3.				apoptosis|cell junction assembly|induction of apoptosis by extracellular signals|JNK cascade|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity				0	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
ARHGAP4	393	broad.mit.edu	37	X	153176006	153176006	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-6706-01A-11D-1882-08	TCGA-BR-6706-11A-01D-1882-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153176006C>T	uc004fjk.1	-	16	1918	c.1876G>A	c.(1876-1878)GCG>ACG	p.A626T	ARHGAP4_uc004fjj.1_5'UTR|ARHGAP4_uc011mzf.1_Missense_Mutation_p.A603T|ARHGAP4_uc004fjl.1_Missense_Mutation_p.A666T|ARHGAP4_uc010nup.1_Intron	NM_001666	NP_001657	P98171	RHG04_HUMAN	Rho GTPase activating protein 4 isoform 2	626	Rho-GAP.				apoptosis|cytoskeleton organization|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|Rho protein signal transduction	cytosol|focal adhesion|nucleus	Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			central_nervous_system(1)	1	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
