Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_status	validation_method	validation_tumor_sample	validation_alt_allele
CDK11B	984	broad.mit.edu	37	1	1588535	1588536	+	Intron	INS	-	TAA	TAA	rs138141689	by1000genomes	TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:1588535_1588536insTAA	uc001agv.1	-						CDK11B_uc001ags.1_Intron|CDK11B_uc001agt.1_Intron|CDK11B_uc001aha.1_Intron|CDK11B_uc001agw.1_Intron|CDK11B_uc001agy.1_Intron|CDK11B_uc001agx.1_Intron|CDK11B_uc001agz.1_Intron|uc001ahc.1_Intron	NM_033486	NP_277021			cell division cycle 2-like 1 (PITSLRE proteins)						apoptosis|cell proliferation|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			skin(1)	1																		---	---	---	---
KIF2C	11004	broad.mit.edu	37	1	45219630	45219631	+	Intron	INS	-	TTT	TTT	rs9326140		TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:45219630_45219631insTTT	uc001cmg.3	+						KIF2C_uc010olb.1_Intron|KIF2C_uc010olc.1_Intron|KIF2C_uc001cmh.3_Intron	NM_006845	NP_006836			kinesin family member 2C						blood coagulation|cell division|cell proliferation|chromosome segregation|establishment or maintenance of microtubule cytoskeleton polarity|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|kinesin complex|microtubule|nucleus	ATP binding|centromeric DNA binding|microtubule motor activity|microtubule plus-end binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)																	---	---	---	---
Unknown	0	broad.mit.edu	37	1	93744310	93744310	+	Intron	DEL	T	-	-			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:93744310delT	uc001dps.2	-											Homo sapiens cDNA FLJ42965 fis, clone BRSTN2014751.																														---	---	---	---
LGTN	1939	broad.mit.edu	37	1	206766820	206766823	+	Intron	DEL	GAGC	-	-	rs141098886		TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:206766820_206766823delGAGC	uc001heh.2	-						LGTN_uc009xbw.2_Intron	NM_006893	NP_008824			ligatin						intracellular protein transport	cytoplasm	protein binding|receptor activity|translation initiation factor activity				0	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)															---	---	---	---
DHX57	90957	broad.mit.edu	37	2	39082580	39082591	+	Intron	DEL	CAATCAAAAGGA	-	-	rs72020623		TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:39082580_39082591delCAATCAAAAGGA	uc002rrf.2	-						DHX57_uc002rrd.3_5'Flank|DHX57_uc002rre.2_Intron|DHX57_uc002rrg.2_Intron	NM_198963	NP_945314			DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57								ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		all_hematologic(82;0.248)																---	---	---	---
ZNF197	10168	broad.mit.edu	37	3	44672899	44672900	+	Intron	INS	-	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:44672899_44672900insT	uc003cnm.2	+						ZNF197_uc003cnn.2_Intron|ZNF197_uc003cno.2_Intron|ZNF197_uc003cnp.2_Intron	NM_006991	NP_008922			zinc finger protein 197 isoform 1						viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|skin(1)	4				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)														---	---	---	---
ZNF197	10168	broad.mit.edu	37	3	44674311	44674312	+	Intron	INS	-	GT	GT	rs138347455	by1000genomes	TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:44674311_44674312insGT	uc003cnm.2	+						ZNF197_uc003cnn.2_Intron|ZNF197_uc003cno.2_Intron|ZNF197_uc003cnp.2_Intron	NM_006991	NP_008922			zinc finger protein 197 isoform 1						viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|skin(1)	4				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)														---	---	---	---
Unknown	0	broad.mit.edu	37	3	186544793	186544793	+	IGR	DEL	C	-	-			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:186544793delC								RFC4 (20309 upstream) : ADIPOQ (15670 downstream)																																			---	---	---	---
TFRC	7037	broad.mit.edu	37	3	195802438	195802438	+	Intron	DEL	T	-	-	rs71949472		TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:195802438delT	uc003fvz.3	-						TFRC_uc003fwa.3_Intron|TFRC_uc010hzy.2_Intron|TFRC_uc011btr.1_Intron	NM_003234	NP_003225			transferrin receptor						cellular iron ion homeostasis|endocytosis|interspecies interaction between organisms|proteolysis|transferrin transport|transmembrane transport	coated pit|endosome|integral to plasma membrane|melanosome	peptidase activity|transferrin receptor activity			ovary(3)	3	all_cancers(143;1.94e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.36e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.17e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00233)				T	BCL6	NHL								---	---	---	---
ARHGAP24	83478	broad.mit.edu	37	4	86491584	86491585	+	Intron	INS	-	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:86491584_86491585insT	uc003hpk.2	+						ARHGAP24_uc003hpi.1_Intron|ARHGAP24_uc003hpj.2_Intron	NM_001025616	NP_001020787			Rho GTPase activating protein 24 isoform 1						angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell projection|cytoskeleton|cytosol|focal adhesion	GTPase activator activity|protein binding				0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000571)														---	---	---	---
GALNT7	51809	broad.mit.edu	37	4	174235080	174235081	+	Intron	DEL	AT	-	-			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:174235080_174235081delAT	uc003isz.3	+						GALNT7_uc011ckb.1_Intron	NM_017423	NP_059119			polypeptide N-acetylgalactosaminyltransferase 7						protein O-linked glycosylation	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)	1		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;1.87e-18)|Epithelial(43;3.44e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-09)|STAD - Stomach adenocarcinoma(60;0.0019)|GBM - Glioblastoma multiforme(59;0.0119)|LUSC - Lung squamous cell carcinoma(193;0.0199)														---	---	---	---
ERAP2	64167	broad.mit.edu	37	5	96219851	96219851	+	Intron	DEL	T	-	-	rs11337784		TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:96219851delT	uc003kmq.2	+						uc003kmo.1_Intron|ERAP2_uc003kmt.2_Intron|ERAP2_uc003kmr.2_Intron|ERAP2_uc003kms.2_Intron|ERAP2_uc003kmu.2_Intron	NM_022350	NP_071745			endoplasmic reticulum aminopeptidase 2						antigen processing and presentation of endogenous peptide antigen via MHC class I|proteolysis|regulation of blood pressure	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding				0		all_cancers(142;0.000311)|all_epithelial(76;1.54e-06)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0596)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0703)														---	---	---	---
DCP2	167227	broad.mit.edu	37	5	112328171	112328171	+	Intron	DEL	T	-	-			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:112328171delT	uc003kqh.2	+						DCP2_uc011cwa.1_Intron|DCP2_uc010jcc.2_Intron	NM_152624	NP_689837			DCP2 decapping enzyme						exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasmic mRNA processing body|cytosol|nucleus|RNA-induced silencing complex	exoribonuclease activity, producing 5'-phosphomonoesters|manganese ion binding|protein binding|protein binding|RNA binding				0		all_cancers(142;4.41e-05)|all_epithelial(76;3.65e-07)|Colorectal(10;0.00115)|Prostate(80;0.00133)|Ovarian(225;0.0443)		OV - Ovarian serous cystadenocarcinoma(64;6.98e-08)|Epithelial(69;7.87e-08)|all cancers(49;1.06e-05)|COAD - Colon adenocarcinoma(37;0.0123)|Colorectal(14;0.0171)														---	---	---	---
Unknown	0	broad.mit.edu	37	6	131790711	131790711	+	IGR	DEL	A	-	-	rs140329918		TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:131790711delA								AKAP7 (186038 upstream) : ARG1 (103654 downstream)																																			---	---	---	---
CUX1	1523	broad.mit.edu	37	7	101883019	101883020	+	Intron	INS	-	TTTTC	TTTTC	rs10634900		TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:101883019_101883020insTTTTC	uc003uyx.3	+						CUX1_uc003uys.3_Intron|CUX1_uc003uyt.2_Intron|CUX1_uc011kkn.1_Intron|CUX1_uc003uyw.2_Intron|CUX1_uc003uyv.2_Intron|CUX1_uc003uyu.2_Intron	NM_181552	NP_853530			cut-like homeobox 1 isoform a						negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8																		---	---	---	---
LAMB1	3912	broad.mit.edu	37	7	107603153	107603153	+	Intron	DEL	A	-	-	rs10712981		TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:107603153delA	uc003vew.2	-						LAMB1_uc003vev.2_Intron|LAMB1_uc003vex.2_Intron	NM_002291	NP_002282			laminin, beta 1 precursor						axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
SLC13A1	6561	broad.mit.edu	37	7	122755345	122755345	+	3'UTR	DEL	A	-	-	rs10709989		TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:122755345delA	uc003vkm.2	-	15					SLC13A1_uc010lks.2_3'UTR	NM_022444	NP_071889			solute carrier family 13 (sodium/sulfate							integral to membrane|plasma membrane	sodium:sulfate symporter activity			ovary(2)	2					Succinic acid(DB00139)													---	---	---	---
TTC26	79989	broad.mit.edu	37	7	138853316	138853316	+	Intron	DEL	A	-	-	rs112942380		TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:138853316delA	uc003vus.2	+						TTC26_uc011kqn.1_Intron|TTC26_uc011kqo.1_Intron|TTC26_uc011kqp.1_Intron|TTC26_uc003vut.2_Intron|TTC26_uc011kqq.1_Intron	NM_024926	NP_079202			tetratricopeptide repeat domain 26 isoform 1								binding			ovary(1)	1																		---	---	---	---
RBM33	155435	broad.mit.edu	37	7	155458153	155458154	+	Intron	INS	-	C	C			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:155458153_155458154insC	uc010lqk.1	+						RBM33_uc003wme.2_Intron	NM_053043	NP_444271			RNA binding motif protein 33								nucleotide binding|RNA binding			ovary(1)	1	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)														---	---	---	---
DEFB4A	1673	broad.mit.edu	37	8	7752467	7752467	+	Intron	DEL	T	-	-	rs113684211		TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:7752467delT	uc003wsd.2	+							NM_004942	NP_004933			defensin, beta 4 precursor						chemotaxis|defense response to bacterium|G-protein coupled receptor protein signaling pathway|immune response	extracellular region					0																		---	---	---	---
OSR2	116039	broad.mit.edu	37	8	99962748	99962748	+	Intron	DEL	A	-	-			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:99962748delA	uc003yir.2	+						OSR2_uc010mbn.2_Intron|OSR2_uc003yiq.2_Intron|OSR2_uc011lgx.1_Intron	NM_001142462	NP_001135934			odd-skipped related 2 isoform a						bone morphogenesis|chondrocyte differentiation|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic leg joint morphogenesis|embryonic skeletal joint morphogenesis|eyelid development in camera-type eye|head development|mesonephros development|metanephros development|middle ear morphogenesis|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|osteoblast proliferation|palate development|positive regulation of bone mineralization|positive regulation of epithelial cell proliferation|positive regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|zinc ion binding			central_nervous_system(1)	1	Breast(36;4.14e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.0136)															---	---	---	---
FER1L6	654463	broad.mit.edu	37	8	125034095	125034096	+	Intron	INS	-	T	T	rs138450142	by1000genomes	TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:125034095_125034096insT	uc003yqw.2	+						uc003yqx.1_Intron	NM_001039112	NP_001034201			fer-1-like 6							integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)															---	---	---	---
TOPORS	10210	broad.mit.edu	37	9	32541246	32541246	+	3'UTR	DEL	A	-	-	rs78113455		TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:32541246delA	uc003zrb.2	-	3					TOPORS_uc003zrc.2_3'UTR	NM_005802	NP_005793			topoisomerase I binding, arginine/serine-rich						DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)														---	---	---	---
FAM74A3	728495	broad.mit.edu	37	9	40715923	40715924	+	RNA	DEL	AA	-	-	rs62565543		TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:40715923_40715924delAA	uc010mmk.2	+	1		c.400_401delAA				NR_026801				Homo sapiens family with sequence similarity 74, member A3 (FAM74A3), non-coding RNA.											skin(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)														---	---	---	---
Unknown	0	broad.mit.edu	37	9	65979067	65979067	+	IGR	DEL	T	-	-			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:65979067delT								FAM74A4 (484681 upstream) : LOC442421 (517403 downstream)																																			---	---	---	---
P4HA1	5033	broad.mit.edu	37	10	74804989	74804989	+	Intron	DEL	T	-	-			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:74804989delT	uc010qka.1	-						P4HA1_uc001jtg.2_Intron|P4HA1_uc001jth.2_Intron|P4HA1_uc010qkb.1_Intron|P4HA1_uc001jti.2_Intron	NM_001142595	NP_001136067			prolyl 4-hydroxylase, alpha I subunit isoform 2							endoplasmic reticulum lumen|mitochondrion	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity			ovary(1)	1	Prostate(51;0.0198)				Hydralazine(DB01275)|L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)													---	---	---	---
USH1C	10083	broad.mit.edu	37	11	17517382	17517383	+	Intron	DEL	AT	-	-	rs138767394		TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:17517382_17517383delAT	uc001mnf.2	-						USH1C_uc001mne.2_Intron|USH1C_uc009yhb.2_Intron|USH1C_uc001mng.2_Intron|USH1C_uc001mnd.2_Intron	NM_005709	NP_005700			harmonin isoform a						equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			ovary(1)	1																		---	---	---	---
MACROD1	28992	broad.mit.edu	37	11	63766402	63766405	+	Intron	DEL	CCGT	-	-			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:63766402_63766405delCCGT	uc001nyh.2	-							NM_014067	NP_054786			MACRO domain containing 1												0																		---	---	---	---
ATM	472	broad.mit.edu	37	11	108206869	108206869	+	Intron	DEL	A	-	-			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:108206869delA	uc001pkb.1	+						ATM_uc009yxr.1_Intron|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_Intron|ATM_uc001pke.1_Intron	NM_000051	NP_000042			ataxia telangiectasia mutated isoform 1						cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)				D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			---	---	---	---
LRCH1	23143	broad.mit.edu	37	13	47279680	47279681	+	Intron	INS	-	T	T	rs146461842	by1000genomes	TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:47279680_47279681insT	uc001vbj.2	+						LRCH1_uc010acp.2_3'UTR|LRCH1_uc001vbk.2_Intron|LRCH1_uc001vbl.3_Intron	NM_015116	NP_055931			leucine-rich repeats and calponin homology (CH)											ovary(1)|central_nervous_system(1)	2		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)														---	---	---	---
UCHL3	7347	broad.mit.edu	37	13	76123902	76123916	+	5'Flank	DEL	GGCGGCGGCGGCGAA	-	-	rs67763278		TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:76123902_76123916delGGCGGCGGCGGCGAA	uc001vjq.2	+							NM_006002	NP_005993			ubiquitin carboxyl-terminal esterase L3						ubiquitin-dependent protein catabolic process	cytoplasm	cysteine-type peptidase activity|ubiquitin binding|ubiquitin thiolesterase activity				0				GBM - Glioblastoma multiforme(99;0.0125)												OREG0022446	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
METT11D1	64745	broad.mit.edu	37	14	21461046	21461047	+	Intron	INS	-	A	A	rs146195385	by1000genomes	TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:21461046_21461047insA	uc001vyn.2	+						METT11D1_uc010tlk.1_3'UTR|METT11D1_uc001vym.2_Intron|METT11D1_uc001vyo.2_Intron|METT11D1_uc001vyp.2_Intron|METT11D1_uc001vyq.2_Intron	NM_022734	NP_073571			methyltransferase 11 domain containing 1 isoform						translation	mitochondrion|ribosome	copper ion binding|methyltransferase activity				0	all_cancers(95;0.00267)		OV - Ovarian serous cystadenocarcinoma(11;1.34e-10)|Epithelial(56;1.57e-08)|all cancers(55;7.45e-08)	GBM - Glioblastoma multiforme(265;0.0191)														---	---	---	---
ACIN1	22985	broad.mit.edu	37	14	23550267	23550267	+	Intron	DEL	T	-	-			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:23550267delT	uc001wit.3	-						ACIN1_uc001wis.3_5'Flank|ACIN1_uc010akg.2_Intron|ACIN1_uc010tnj.1_Intron	NM_014977	NP_055792			apoptotic chromatin condensation inducer 1						apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)														---	---	---	---
Unknown	0	broad.mit.edu	37	14	75340954	75340955	+	IGR	INS	-	T	T	rs35863744		TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:75340954_75340955insT								PROX2 (10417 upstream) : DLST (7639 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	15	22566684	22566684	+	IGR	DEL	A	-	-			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:22566684delA								MIR1268 (53404 upstream) : GOLGA8DP (135601 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	16	28617930	28617931	+	Intron	INS	-	G	G	rs143299878	by1000genomes	TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:28617930_28617931insG	uc010vct.1	-						SULT1A1_uc002dqi.2_Intron|SULT1A1_uc002dqj.2_Intron|SULT1A1_uc002dqk.2_Intron|SULT1A1_uc002dql.2_Intron|SULT1A1_uc002dqm.2_Intron|SULT1A1_uc002dqn.2_Intron|SULT1A1_uc002dqo.2_Intron|SULT1A1_uc002dqp.2_Intron					RecName: Full=Nuclear pore complex-interacting protein-like 2; Flags: Precursor;																														---	---	---	---
Unknown	0	broad.mit.edu	37	16	34582742	34582746	+	IGR	DEL	ATTTT	-	-			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:34582742_34582746delATTTT								UBE2MP1 (177980 upstream) : LOC283914 (15041 downstream)																																			---	---	---	---
FANCA	2175	broad.mit.edu	37	16	89874491	89874497	+	Intron	DEL	CAAAACC	-	-	rs67590431		TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:89874491_89874497delCAAAACC	uc002fou.1	-						FANCA_uc010vpn.1_Intron|FANCA_uc002fov.1_Intron|FANCA_uc002fow.1_Intron|FANCA_uc002fox.1_Intron|FANCA_uc010ciu.1_Intron|FANCA_uc002foy.2_Intron	NM_000135	NP_000126			Fanconi anemia, complementation group A isoform						DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)				D|Mis|N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				---	---	---	---
FXR2	9513	broad.mit.edu	37	17	7495379	7495380	+	Intron	DEL	TC	-	-	rs138014385		TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7495379_7495380delTC	uc002gia.1	-						MPDU1_uc010vuc.1_Intron|SOX15_uc002ghy.1_5'Flank|SOX15_uc002ghz.1_5'Flank	NM_004860	NP_004851			fragile X mental retardation syndrome related							cytosolic large ribosomal subunit	protein binding|RNA binding				0				READ - Rectum adenocarcinoma(115;0.17)														---	---	---	---
MYH2	4620	broad.mit.edu	37	17	10424898	10424899	+	Intron	DEL	AT	-	-	rs147245930		TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:10424898_10424899delAT	uc010coi.2	-						uc002gml.1_Intron|MYH2_uc002gmp.3_Intron|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582			myosin heavy chain IIa						muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14																		---	---	---	---
TBC1D3P2	440452	broad.mit.edu	37	17	60347260	60347260	+	Intron	DEL	T	-	-	rs71934275		TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:60347260delT	uc002izq.2	-						TBC1D3P2_uc010woz.1_Intron|uc010wpa.1_5'Flank					SubName: Full=Putative uncharacterized protein TBC1D3E;												0																		---	---	---	---
CCDC46	201134	broad.mit.edu	37	17	64025820	64025821	+	Intron	INS	-	TAAA	TAAA	rs144628903	by1000genomes	TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:64025820_64025821insTAAA	uc002jfl.2	-						CCDC46_uc010deo.2_Intron|CCDC46_uc002jfm.2_Intron|CCDC46_uc010dep.2_Intron	NM_145036	NP_659473			coiled-coil domain containing 46 isoform a							centrosome					0			BRCA - Breast invasive adenocarcinoma(6;1.53e-06)															---	---	---	---
MYOM1	8736	broad.mit.edu	37	18	3085192	3085192	+	Intron	DEL	T	-	-	rs148266515		TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:3085192delT	uc002klp.2	-						MYOM1_uc002klq.2_Intron	NM_003803	NP_003794			myomesin 1 isoform a							striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5																		---	---	---	---
KIAA1328	57536	broad.mit.edu	37	18	34465687	34465687	+	Intron	DEL	T	-	-			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:34465687delT	uc002kzz.2	+							NM_020776	NP_065827			hypothetical protein LOC57536											central_nervous_system(1)	1				COAD - Colon adenocarcinoma(74;0.195)														---	---	---	---
MUM1	84939	broad.mit.edu	37	19	1376311	1376311	+	Intron	DEL	T	-	-			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:1376311delT	uc010xgm.1	+						MUM1_uc002lrz.2_Intron|MUM1_uc002lsb.2_Intron|MUM1_uc002lsd.2_Intron					SubName: Full=MUM1 protein;						chromatin organization|DNA repair	nucleus	nucleosome binding|protein binding				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
PEX11G	92960	broad.mit.edu	37	19	7542209	7542209	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:7542209delC	uc002mgk.1	-	5	614	c.605delG	c.(604-606)GGCfs	p.G202fs	PEX11G_uc002mgl.1_Frame_Shift_Del_p.G132fs	NM_080662	NP_542393	Q96HA9	PX11C_HUMAN	peroxisomal biogenesis factor 11 gamma	202	Lumenal (Potential).					integral to membrane|peroxisomal membrane					0																		---	---	---	---
PDCD2L	84306	broad.mit.edu	37	19	34896048	34896049	+	Intron	INS	-	T	T	rs74177144		TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:34896048_34896049insT	uc002nvj.2	+							NM_032346	NP_115722			programmed cell death 2-like							cytoplasm				ovary(1)	1	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)															---	---	---	---
Unknown	0	broad.mit.edu	37	20	26113543	26113543	+	IGR	DEL	A	-	-			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:26113543delA								C20orf191 (18866 upstream) : MIR663 (75279 downstream)																																			---	---	---	---
PIGU	128869	broad.mit.edu	37	20	33232991	33232992	+	Intron	INS	-	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:33232991_33232992insA	uc002xas.2	-						PIGU_uc010zul.1_Intron|PIGU_uc002xat.2_Intron|PIGU_uc010gev.1_Intron	NM_080476	NP_536724			phosphatidylinositol glycan anchor biosynthesis,						attachment of GPI anchor to protein|C-terminal protein lipidation|regulation of JAK-STAT cascade	GPI-anchor transamidase complex|plasma membrane					0																		---	---	---	---
COL9A3	1299	broad.mit.edu	37	20	61463679	61463689	+	Intron	DEL	AGTCGCCCTTT	-	-	rs143006001		TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:61463679_61463689delAGTCGCCCTTT	uc002ydm.2	+							NM_001853	NP_001844			alpha 3 type IX collagen precursor						axon guidance	collagen type IX					0	Breast(26;5.68e-08)																	---	---	---	---
KCNQ2	3785	broad.mit.edu	37	20	62074452	62074453	+	Intron	INS	-	CAC	CAC	rs139636562	by1000genomes	TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:62074452_62074453insCAC	uc002yey.1	-						KCNQ2_uc002yez.1_Intron|KCNQ2_uc002yfa.1_Intron|KCNQ2_uc002yfb.1_Intron|KCNQ2_uc011aax.1_Intron|KCNQ2_uc002yfc.1_Intron	NM_172107	NP_742105			potassium voltage-gated channel KQT-like protein						axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)													---	---	---	---
COL6A1	1291	broad.mit.edu	37	21	47417148	47417160	+	Intron	DEL	CAGGCCCTTCGTG	-	-	rs58559163		TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:47417148_47417160delCAGGCCCTTCGTG	uc002zhu.1	+						COL6A1_uc010gqd.1_5'Flank	NM_001848	NP_001839			collagen, type VI, alpha 1 precursor						axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			ovary(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)													---	---	---	---
APOL5	80831	broad.mit.edu	37	22	36113785	36113786	+	5'Flank	INS	-	AA	AA	rs71322979		TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:36113785_36113786insAA	uc003aof.2	+							NM_030642	NP_085145			apolipoprotein L5						lipid metabolic process|lipid transport|lipoprotein metabolic process	cytoplasm|extracellular region	high-density lipoprotein particle binding|lipid binding|protein binding				0																		---	---	---	---
ASMTL	8623	broad.mit.edu	37	X	1536698	1536701	+	Intron	DEL	AGAG	-	-			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:1536698_1536701delAGAG	uc004cpx.1	-						ASMTL_uc011mhe.1_Intron|ASMTL_uc004cpy.1_Intron|ASMTL_uc011mhf.1_Intron	NM_004192	NP_004183			acetylserotonin O-methyltransferase-like						melatonin biosynthetic process	cytoplasm	acetylserotonin O-methyltransferase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)																---	---	---	---
CD40LG	959	broad.mit.edu	37	X	135732732	135732733	+	Intron	INS	-	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:135732732_135732733insA	uc004faa.2	+						CD40LG_uc010nsd.2_Intron|CD40LG_uc010nse.1_Intron	NM_000074	NP_000065			CD40 ligand						anti-apoptosis|B cell proliferation|inflammatory response|isotype switching|leukocyte cell-cell adhesion|platelet activation|positive regulation of endothelial cell apoptosis|positive regulation of interleukin-12 production	extracellular space|integral to plasma membrane|soluble fraction	CD40 receptor binding|cytokine activity|tumor necrosis factor receptor binding			skin(1)	1	Acute lymphoblastic leukemia(192;0.000127)				Atorvastatin(DB01076)									Immune_Deficiency_with_Hyper-IgM				---	---	---	---
E2F2	1870	broad.mit.edu	37	1	23847554	23847554	+	Silent	SNP	T	C	C			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:23847554T>C	uc001bhe.1	-	4	1016	c.588A>G	c.(586-588)GGA>GGG	p.G196G		NM_004091	NP_004082	Q14209	E2F2_HUMAN	E2F transcription factor 2	196	DEF box.|Potential.				G1 phase of mitotic cell cycle|transcription initiation from RNA polymerase II promoter	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(2)|skin(2)	4		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.52e-24)|Colorectal(126;6.25e-08)|COAD - Colon adenocarcinoma(152;3.42e-06)|GBM - Glioblastoma multiforme(114;8.98e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00102)|KIRC - Kidney renal clear cell carcinoma(1967;0.00366)|STAD - Stomach adenocarcinoma(196;0.0132)|READ - Rectum adenocarcinoma(331;0.0652)|Lung(427;0.0888)|LUSC - Lung squamous cell carcinoma(448;0.19)														---	---	---	---
HOOK1	51361	broad.mit.edu	37	1	60331609	60331609	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:60331609G>A	uc009wad.2	+	20	1912	c.1810G>A	c.(1810-1812)GAA>AAA	p.E604K	HOOK1_uc001czo.2_Missense_Mutation_p.E604K|HOOK1_uc001czp.2_RNA|HOOK1_uc010oor.1_Missense_Mutation_p.E562K	NM_015888	NP_056972	Q9UJC3	HOOK1_HUMAN	hook homolog 1	604	Potential.				early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|multicellular organismal development|protein transport	FHF complex|microtubule	identical protein binding			ovary(1)|breast(1)	2	all_cancers(7;0.000129)																	---	---	---	---
CLCA4	22802	broad.mit.edu	37	1	87029424	87029424	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:87029424G>A	uc009wcs.2	+	4	573	c.529G>A	c.(529-531)GCT>ACT	p.A177T	CLCA4_uc009wct.2_Intron|CLCA4_uc009wcu.2_Intron	NM_012128	NP_036260	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	177						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			ovary(2)	2		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)														---	---	---	---
GBP6	163351	broad.mit.edu	37	1	89843764	89843764	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:89843764C>A	uc001dnf.2	+	4	695	c.421C>A	c.(421-423)CAG>AAG	p.Q141K	GBP6_uc010ost.1_Missense_Mutation_p.Q11K	NM_198460	NP_940862	Q6ZN66	GBP6_HUMAN	guanylate binding protein family, member 6	141							GTP binding|GTPase activity			ovary(2)	2		Lung NSC(277;0.0908)		all cancers(265;0.0108)|Epithelial(280;0.0398)														---	---	---	---
VAV3	10451	broad.mit.edu	37	1	108247692	108247692	+	Intron	SNP	A	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:108247692A>G	uc001dvk.1	-						VAV3_uc010ouw.1_Intron|VAV3_uc001dvl.1_Intron|VAV3_uc010oux.1_Intron	NM_006113	NP_006104			vav 3 guanine nucleotide exchange factor isoform						angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(5)|lung(2)|breast(2)	9		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)														---	---	---	---
SORT1	6272	broad.mit.edu	37	1	109870198	109870198	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:109870198T>C	uc001dxm.1	-	12	1446	c.1397A>G	c.(1396-1398)TAC>TGC	p.Y466C	SORT1_uc010ovi.1_Missense_Mutation_p.Y329C	NM_002959	NP_002950	Q99523	SORT_HUMAN	sortilin 1 preproprotein	466	Extracellular (Potential).				endocytosis|endosome to lysosome transport|endosome transport via multivesicular body sorting pathway|glucose import|Golgi to endosome transport|induction of apoptosis by extracellular signals|myotube differentiation|negative regulation of apoptosis|negative regulation of lipoprotein lipase activity|neuropeptide signaling pathway|ossification|plasma membrane to endosome transport|regulation of gene expression|response to insulin stimulus|vesicle organization	cell surface|coated pit|early endosome|endoplasmic reticulum membrane|endosome membrane|Golgi cisterna membrane|integral to membrane|lysosomal membrane|microsome|nuclear membrane|perinuclear region of cytoplasm|plasma membrane	enzyme binding|nerve growth factor binding|nerve growth factor receptor activity|neurotensin receptor activity, non-G-protein coupled			ovary(1)	1		all_epithelial(167;4.69e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0529)|Colorectal(144;0.142)|Epithelial(280;0.145)|Kidney(133;0.169)|all cancers(265;0.184)														---	---	---	---
PTPN22	26191	broad.mit.edu	37	1	114357554	114357554	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:114357554C>A	uc001eds.2	-	21	2527	c.2397G>T	c.(2395-2397)AGG>AGT	p.R799S	RSBN1_uc001edq.2_5'Flank|RSBN1_uc001edr.2_5'Flank|PTPN22_uc009wgq.2_Missense_Mutation_p.R744S|PTPN22_uc010owo.1_Missense_Mutation_p.R555S|PTPN22_uc001edt.2_3'UTR	NM_015967	NP_057051	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type	799					negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			kidney(2)|lung(1)|skin(1)	4	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)														---	---	---	---
PTPN22	26191	broad.mit.edu	37	1	114357555	114357555	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:114357555C>A	uc001eds.2	-	21	2526	c.2396G>T	c.(2395-2397)AGG>ATG	p.R799M	RSBN1_uc001edq.2_5'Flank|RSBN1_uc001edr.2_5'Flank|PTPN22_uc009wgq.2_Missense_Mutation_p.R744M|PTPN22_uc010owo.1_Missense_Mutation_p.R555M|PTPN22_uc001edt.2_3'UTR	NM_015967	NP_057051	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type	799					negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			kidney(2)|lung(1)|skin(1)	4	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)														---	---	---	---
HORMAD1	84072	broad.mit.edu	37	1	150680760	150680760	+	Silent	SNP	C	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:150680760C>T	uc001evk.1	-	9	625	c.519G>A	c.(517-519)TTG>TTA	p.L173L	HORMAD1_uc001evl.1_Silent_p.L166L|HORMAD1_uc001evm.1_Silent_p.L93L	NM_032132	NP_115508	Q86X24	HORM1_HUMAN	HORMA domain containing 1	173	HORMA.				blastocyst development|cell differentiation|meiotic DNA double-strand break formation|meiotic recombination checkpoint|meiotic sister chromatid cohesion|mitosis|oogenesis|regulation of homologous chromosome segregation|spermatogenesis|synaptonemal complex assembly	chromosome|nucleus				ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.23e-52)|all_epithelial(9;4.68e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.0009)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;2.32e-23)|all cancers(9;5.21e-23)|OV - Ovarian serous cystadenocarcinoma(6;6.72e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)															---	---	---	---
BNIPL	149428	broad.mit.edu	37	1	151010070	151010070	+	Silent	SNP	A	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:151010070A>G	uc001ewl.2	+	2	242	c.69A>G	c.(67-69)GAA>GAG	p.E23E	BNIPL_uc009wmi.2_5'UTR|BNIPL_uc009wmj.2_5'Flank	NM_138278	NP_612122	Q7Z465	BNIPL_HUMAN	BCL2/adenovirus E1B 19kD interacting protein	23					apoptosis|induction of apoptosis|negative regulation of cell proliferation|regulation of growth rate	cytosol|nucleus	identical protein binding				0	Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)															---	---	---	---
CELF3	11189	broad.mit.edu	37	1	151680269	151680269	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:151680269G>T	uc001eys.1	-	6	1423	c.629C>A	c.(628-630)GCC>GAC	p.A210D	CELF3_uc010pdh.1_Missense_Mutation_p.A18D|CELF3_uc001eyr.2_Missense_Mutation_p.A209D|CELF3_uc009wmy.2_Missense_Mutation_p.A210D|CELF3_uc009wmx.1_Missense_Mutation_p.A210D|CELF3_uc001eyt.2_Missense_Mutation_p.A133D|C1orf230_uc001eyu.2_5'Flank	NM_007185	NP_009116	Q5SZQ8	CELF3_HUMAN	trinucleotide repeat containing 4	210					nuclear mRNA splicing, via spliceosome|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	mRNA binding|nucleotide binding			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
TDRD10	126668	broad.mit.edu	37	1	154493818	154493818	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:154493818G>A	uc009wow.2	+	6	1070	c.232G>A	c.(232-234)GGC>AGC	p.G78S	TDRD10_uc001ffd.2_Missense_Mutation_p.G78S|TDRD10_uc001ffe.2_5'UTR	NM_001098475	NP_001091945	Q5VZ19	TDR10_HUMAN	tudor domain containing 10 isoform a	78	RRM.						nucleotide binding|RNA binding			ovary(1)	1	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)															---	---	---	---
ASH1L	55870	broad.mit.edu	37	1	155450973	155450973	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:155450973G>C	uc009wqq.2	-	3	2168	c.1688C>G	c.(1687-1689)TCT>TGT	p.S563C	ASH1L_uc001fkt.2_Missense_Mutation_p.S563C|ASH1L_uc009wqr.1_Missense_Mutation_p.S563C	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	563					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)															---	---	---	---
ISG20L2	81875	broad.mit.edu	37	1	156694024	156694024	+	Silent	SNP	G	A	A	rs61736207	byFrequency;by1000genomes	TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156694024G>A	uc001fps.1	-	2	1125	c.864C>T	c.(862-864)CCC>CCT	p.P288P	ISG20L2_uc001fpt.1_Silent_p.P288P	NM_030980	NP_112242	Q9H9L3	I20L2_HUMAN	interferon stimulated exonuclease gene	288	Exonuclease.				ribosome biogenesis	nucleolus	exonuclease activity|nucleic acid binding|protein binding			ovary(1)|central_nervous_system(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)																	---	---	---	---
SLAMF6	114836	broad.mit.edu	37	1	160461007	160461007	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:160461007G>T	uc001fwe.1	-	3	614	c.554C>A	c.(553-555)CCC>CAC	p.P185H	SLAMF6_uc001fwd.1_Missense_Mutation_p.P185H|SLAMF6_uc010pjh.1_Missense_Mutation_p.P136H|SLAMF6_uc010pji.1_Missense_Mutation_p.P74H|SLAMF6_uc010pjj.1_Missense_Mutation_p.P74H|SLAMF6_uc009wtm.1_Missense_Mutation_p.P136H	NM_052931	NP_443163	Q96DU3	SLAF6_HUMAN	activating NK receptor precursor	185	Extracellular (Potential).|Ig-like.					integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2	all_cancers(52;1.05e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0923)															---	---	---	---
GPA33	10223	broad.mit.edu	37	1	167042757	167042757	+	Silent	SNP	G	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:167042757G>A	uc001gea.1	-	2	407	c.63C>T	c.(61-63)GCC>GCT	p.A21A		NM_005814	NP_005805	Q99795	GPA33_HUMAN	transmembrane glycoprotein A33 precursor	21						integral to plasma membrane	receptor activity				0																		---	---	---	---
F5	2153	broad.mit.edu	37	1	169511446	169511446	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:169511446T>G	uc001ggg.1	-	13	3027	c.2882A>C	c.(2881-2883)GAT>GCT	p.D961A		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	961	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)													---	---	---	---
RC3H1	149041	broad.mit.edu	37	1	173939714	173939714	+	Silent	SNP	A	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:173939714A>G	uc001gju.3	-	8	1350	c.1263T>C	c.(1261-1263)GAT>GAC	p.D421D	RC3H1_uc010pms.1_Silent_p.D421D|RC3H1_uc001gjv.2_Silent_p.D421D|RC3H1_uc010pmt.1_Silent_p.D421D	NM_172071	NP_742068	Q5TC82	RC3H1_HUMAN	roquin	421	C3H1-type.				cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2																		---	---	---	---
IKBKE	9641	broad.mit.edu	37	1	206665007	206665007	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:206665007G>T	uc001hdz.1	+	18	2128	c.1760G>T	c.(1759-1761)AGA>ATA	p.R587I	IKBKE_uc009xbv.1_Missense_Mutation_p.R587I|IKBKE_uc001hea.1_Missense_Mutation_p.R502I	NM_014002	NP_054721	Q14164	IKKE_HUMAN	IKK-related kinase epsilon	587					DNA damage response, signal transduction resulting in induction of apoptosis|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane|PML body	ATP binding|IkappaB kinase activity|NF-kappaB-inducing kinase activity|protein binding			ovary(3)|lung(3)|central_nervous_system(1)|skin(1)	8	Breast(84;0.137)																	---	---	---	---
PPP2R5A	5525	broad.mit.edu	37	1	212530487	212530487	+	Intron	SNP	G	C	C			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:212530487G>C	uc001hjb.2	+						PPP2R5A_uc010ptd.1_Intron	NM_006243	NP_006234			protein phosphatase 2, regulatory subunit B						negative regulation of establishment of protein localization in plasma membrane|negative regulation of lipid kinase activity|positive regulation of protein dephosphorylation|signal transduction	chromosome, centromeric region|cytoplasm|nucleus|protein phosphatase type 2A complex	kinase binding|protein phosphatase type 2A regulator activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0125)|all cancers(67;0.029)|Epithelial(68;0.154)|GBM - Glioblastoma multiforme(131;0.155)														---	---	---	---
PTPN14	5784	broad.mit.edu	37	1	214549783	214549783	+	Intron	SNP	G	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:214549783G>A	uc001hkk.1	-						PTPN14_uc010pty.1_Intron	NM_005401	NP_005392			protein tyrosine phosphatase, non-receptor type						lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			breast(2)|ovary(1)|kidney(1)|skin(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)														---	---	---	---
OBSCN	84033	broad.mit.edu	37	1	228404967	228404967	+	Silent	SNP	G	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:228404967G>A	uc009xez.1	+	8	2675	c.2631G>A	c.(2629-2631)GTG>GTA	p.V877V	OBSCN_uc001hsn.2_Silent_p.V877V	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	877	Ig-like 8.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)																---	---	---	---
MTR	4548	broad.mit.edu	37	1	237060413	237060413	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:237060413G>C	uc001hyi.3	+	32	4129	c.3706G>C	c.(3706-3708)GAT>CAT	p.D1236H	MTR_uc010pxw.1_Missense_Mutation_p.D829H|MTR_uc010pxx.1_Missense_Mutation_p.D1185H|MTR_uc010pxy.1_Missense_Mutation_p.D1090H	NM_000254	NP_000245	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine	1236	AdoMet activation.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)													---	---	---	---
ALLC	55821	broad.mit.edu	37	2	3730541	3730541	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:3730541G>C	uc010ewt.2	+	7	549	c.388G>C	c.(388-390)GAC>CAC	p.D130H		NM_018436	NP_060906	Q8N6M5	ALLC_HUMAN	allantoicase isoform a	149							allantoicase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.088)	all_cancers(51;0.24)		OV - Ovarian serous cystadenocarcinoma(76;0.088)|all cancers(51;0.151)|Epithelial(75;0.206)											HNSCC(21;0.051)			---	---	---	---
SLC5A6	8884	broad.mit.edu	37	2	27424276	27424276	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27424276G>T	uc002rjd.2	-	15	1981	c.1590C>A	c.(1588-1590)TAC>TAA	p.Y530*	SLC5A6_uc010eyv.1_Nonsense_Mutation_p.Y530*	NM_021095	NP_066918	Q9Y289	SC5A6_HUMAN	solute carrier family 5 (sodium-dependent	530	Helical; (Potential).				biotin metabolic process|pantothenate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Biotin(DB00121)|Lipoic Acid(DB00166)													---	---	---	---
ZNF512	84450	broad.mit.edu	37	2	27826177	27826177	+	Intron	SNP	G	C	C			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27826177G>C	uc002rla.2	+						ZNF512_uc010ylv.1_Intron|ZNF512_uc010ylw.1_Intron|ZNF512_uc002rlb.2_Intron|ZNF512_uc010ylx.1_Intron|ZNF512_uc002rlc.2_Intron|ZNF512_uc010yly.1_Intron|ZNF512_uc010ylz.1_Intron	NM_032434	NP_115810			zinc finger protein 512						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
SLC4A1AP	22950	broad.mit.edu	37	2	27888079	27888079	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27888079A>T	uc002rlk.3	+	2	1220	c.938A>T	c.(937-939)GAT>GTT	p.D313V	SUPT7L_uc002rlh.1_5'Flank|SUPT7L_uc002rli.1_5'Flank|SUPT7L_uc010ymf.1_5'Flank|SUPT7L_uc002rlj.1_5'Flank|SUPT7L_uc010ezh.1_5'Flank	NM_018158	NP_060628	Q9BWU0	NADAP_HUMAN	solute carrier family 4 (anion exchanger),	313						cytoplasm|nucleus	double-stranded RNA binding|protein binding				0	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
ANKRD53	79998	broad.mit.edu	37	2	71206308	71206308	+	Silent	SNP	C	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:71206308C>T	uc002shl.3	+	2	453	c.252C>T	c.(250-252)ACC>ACT	p.T84T	ANKRD53_uc002shk.3_Silent_p.T84T|ANKRD53_uc002shm.3_Intron	NM_001115116	NP_001108588	Q8N9V6	ANR53_HUMAN	ankyrin repeat domain 53 isoform a	84											0																		---	---	---	---
DGUOK	1716	broad.mit.edu	37	2	74154045	74154045	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:74154045C>T	uc002sjx.2	+	1	93	c.8C>T	c.(7-9)GCG>GTG	p.A3V	DGUOK_uc002sjy.2_Missense_Mutation_p.A3V|DGUOK_uc002sjz.2_RNA	NM_080916	NP_550438	Q16854	DGUOK_HUMAN	deoxyguanosine kinase isoform a precursor	3					guanosine metabolic process|purine base metabolic process|purine deoxyribonucleoside metabolic process|purine-containing compound salvage	mitochondrial matrix	ATP binding|deoxyguanosine kinase activity|phosphotransferase activity, alcohol group as acceptor				0																		---	---	---	---
REG1B	5968	broad.mit.edu	37	2	79313512	79313512	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:79313512C>A	uc002sny.2	-	4	414	c.302G>T	c.(301-303)GGC>GTC	p.G101V	REG1B_uc010ffv.1_Missense_Mutation_p.G101V|REG1B_uc010ffw.2_3'UTR	NM_006507	NP_006498	P48304	REG1B_HUMAN	regenerating islet-derived 1 beta precursor	101	C-type lectin.				cell proliferation	extracellular region	sugar binding			central_nervous_system(1)|skin(1)	2																		---	---	---	---
ACVR1	90	broad.mit.edu	37	2	158634764	158634764	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:158634764A>T	uc002tzm.3	-	6	761	c.422T>A	c.(421-423)CTG>CAG	p.L141Q	ACVR1_uc002tzn.3_Missense_Mutation_p.L141Q|ACVR1_uc010fog.2_Missense_Mutation_p.L141Q	NM_001111067	NP_001104537	Q04771	ACVR1_HUMAN	activin A receptor, type I precursor	141	Helical; (Potential).				BMP signaling pathway|G1/S transition of mitotic cell cycle|negative regulation of activin receptor signaling pathway|negative regulation of apoptosis|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	activin receptor complex	activin binding|ATP binding|follistatin binding|metal ion binding|protein homodimerization activity|SMAD binding|transforming growth factor beta binding			ovary(2)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.104)	Adenosine triphosphate(DB00171)													---	---	---	---
WIPF1	7456	broad.mit.edu	37	2	175440117	175440117	+	Intron	SNP	G	C	C			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:175440117G>C	uc002uiy.2	-						uc002uiw.2_Intron|uc002uix.1_Intron|WIPF1_uc002uja.2_Intron|WIPF1_uc010fqt.1_Intron|WIPF1_uc002ujc.1_Intron|WIPF1_uc002uiz.2_Intron|WIPF1_uc002ujb.1_Intron|WIPF1_uc010zep.1_Intron	NM_003387	NP_003378			WAS/WASL interacting protein family, member 1						actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			ovary(1)|skin(1)	2																		---	---	---	---
TTN	7273	broad.mit.edu	37	2	179597039	179597039	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179597039G>A	uc010zfg.1	-	54	13149	c.12925C>T	c.(12925-12927)CAG>TAG	p.Q4309*	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Nonsense_Mutation_p.Q970*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5236							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
NBEAL1	65065	broad.mit.edu	37	2	204003442	204003442	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:204003442C>G	uc002uzt.3	+	30	5065	c.4732C>G	c.(4732-4734)CTA>GTA	p.L1578V	NBEAL1_uc002uzs.3_Missense_Mutation_p.L288V	NM_001114132	NP_001107604	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1 isoform 3	1578							binding			ovary(1)|skin(1)	2																		---	---	---	---
PER2	8864	broad.mit.edu	37	2	239181794	239181794	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:239181794C>T	uc002vyc.2	-	5	724	c.487G>A	c.(487-489)GGT>AGT	p.G163S	PER2_uc010znv.1_Missense_Mutation_p.G163S|PER2_uc010znw.1_Missense_Mutation_p.G163S|PER2_uc010fyx.1_Missense_Mutation_p.G163S	NM_022817	NP_073728	O15055	PER2_HUMAN	period 2	163					circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			upper_aerodigestive_tract(1)|breast(1)	2		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)														---	---	---	---
FGD5	152273	broad.mit.edu	37	3	14949227	14949227	+	Intron	SNP	C	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:14949227C>G	uc003bzc.2	+						FGD5_uc011avk.1_Intron|FGD5_uc003bzd.2_Intron	NM_152536	NP_689749			FYVE, RhoGEF and PH domain containing 5						actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5																		---	---	---	---
SEMA5B	54437	broad.mit.edu	37	3	122631107	122631107	+	Silent	SNP	G	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:122631107G>A	uc003efz.1	-	19	3112	c.2808C>T	c.(2806-2808)TCC>TCT	p.S936S	SEMA5B_uc011bju.1_Intron|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Silent_p.S936S|SEMA5B_uc003efy.1_5'UTR	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	936	Extracellular (Potential).|TSP type-1 4.				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)														---	---	---	---
TOPBP1	11073	broad.mit.edu	37	3	133374275	133374275	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:133374275G>C	uc003eps.2	-	6	733	c.601C>G	c.(601-603)CTT>GTT	p.L201V		NM_007027	NP_008958	Q92547	TOPB1_HUMAN	topoisomerase (DNA) II binding protein 1	201	BRCT 2.				DNA repair|response to ionizing radiation	microtubule organizing center|PML body|spindle pole	DNA binding|protein C-terminus binding			ovary(2)|kidney(2)|skin(1)|lung(1)|pancreas(1)	7													Other_conserved_DNA_damage_response_genes					---	---	---	---
GPR149	344758	broad.mit.edu	37	3	154146753	154146753	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:154146753A>G	uc003faa.2	-	1	752	c.652T>C	c.(652-654)TGT>CGT	p.C218R		NM_001038705	NP_001033794	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	218	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(6)	6			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)															---	---	---	---
PLCH1	23007	broad.mit.edu	37	3	155203145	155203145	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:155203145C>G	uc011bok.1	-	22	3275	c.2998G>C	c.(2998-3000)GCA>CCA	p.A1000P	PLCH1_uc011boj.1_Missense_Mutation_p.V1000L|PLCH1_uc011bol.1_Missense_Mutation_p.A962P	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	1000					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)															---	---	---	---
SI	6476	broad.mit.edu	37	3	164733853	164733853	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:164733853C>G	uc003fei.2	-	32	3837	c.3775G>C	c.(3775-3777)GAC>CAC	p.D1259H		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1259	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)										HNSCC(35;0.089)			---	---	---	---
ARAP2	116984	broad.mit.edu	37	4	36115912	36115912	+	Intron	SNP	G	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:36115912G>A	uc003gsq.1	-							NM_015230	NP_056045			ArfGAP with RhoGAP domain, ankyrin repeat and PH						regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3																		---	---	---	---
ATP8A1	10396	broad.mit.edu	37	4	42416720	42416720	+	Silent	SNP	C	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:42416720C>T	uc003gwr.2	-	36	3553	c.3321G>A	c.(3319-3321)GCG>GCA	p.A1107A	ATP8A1_uc003gwq.2_Silent_p.A333A|ATP8A1_uc003gws.2_Silent_p.A1092A	NM_006095	NP_006086	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT),	1107	Cytoplasmic (Potential).				ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			skin(2)|central_nervous_system(1)	3					Phosphatidylserine(DB00144)													---	---	---	---
FRYL	285527	broad.mit.edu	37	4	48524956	48524956	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:48524956C>T	uc003gyh.1	-	54	8088	c.7483G>A	c.(7483-7485)GCA>ACA	p.A2495T	FRYL_uc003gyf.1_5'Flank|FRYL_uc003gyg.1_Missense_Mutation_p.A1191T|FRYL_uc003gyi.1_Missense_Mutation_p.A1383T|FRYL_uc003gyj.1_Missense_Mutation_p.A790T	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	2495					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1																		---	---	---	---
FAT1	2195	broad.mit.edu	37	4	187540371	187540371	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:187540371G>T	uc003izf.2	-	10	7557	c.7369C>A	c.(7369-7371)CTG>ATG	p.L2457M		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2457	Extracellular (Potential).|Cadherin 22.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12															HNSCC(5;0.00058)			---	---	---	---
SEMA5A	9037	broad.mit.edu	37	5	9197366	9197366	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:9197366C>T	uc003jek.2	-	10	1694	c.982G>A	c.(982-984)GCG>ACG	p.A328T		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	328	Sema.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2																		---	---	---	---
CDH9	1007	broad.mit.edu	37	5	26915754	26915754	+	Silent	SNP	A	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:26915754A>G	uc003jgs.1	-	3	676	c.507T>C	c.(505-507)CCT>CCC	p.P169P	CDH9_uc010iug.2_Silent_p.P169P	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	169	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9																		---	---	---	---
PDZD2	23037	broad.mit.edu	37	5	32089228	32089228	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:32089228G>C	uc003jhl.2	+	20	6062	c.5674G>C	c.(5674-5676)GGC>CGC	p.G1892R	PDZD2_uc003jhm.2_Missense_Mutation_p.G1892R	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	1892					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9																		---	---	---	---
ITGA1	3672	broad.mit.edu	37	5	52206033	52206033	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:52206033G>C	uc003jou.2	+	14	1693	c.1641G>C	c.(1639-1641)CAG>CAC	p.Q547H	ITGA1_uc003jov.2_RNA|ITGA1_uc003jow.2_Missense_Mutation_p.Q78H	NM_181501	NP_852478	P56199	ITA1_HUMAN	integrin, alpha 1 precursor	547	Extracellular (Potential).				axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|muscle contraction	integrin complex	collagen binding|receptor activity			ovary(2)|lung(1)	3		Lung NSC(810;5.05e-05)|Breast(144;0.0851)																---	---	---	---
CCDC125	202243	broad.mit.edu	37	5	68595886	68595886	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:68595886T>A	uc003jvv.1	-	7	812	c.769A>T	c.(769-771)AAC>TAC	p.N257Y	CCDC125_uc003jvx.1_Missense_Mutation_p.N256Y|CCDC125_uc003jvy.1_RNA|CCDC125_uc003jvw.2_Missense_Mutation_p.N132Y	NM_176816	NP_789786	Q86Z20	CC125_HUMAN	coiled-coil domain containing 125	257						cytoplasm					0		Lung NSC(167;7.26e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.2e-56)|Epithelial(20;2.31e-52)|all cancers(19;5.85e-48)|Lung(70;0.0183)														---	---	---	---
TSLP	85480	broad.mit.edu	37	5	110411751	110411751	+	Silent	SNP	A	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:110411751A>T	uc003kpb.2	+	4	658	c.459A>T	c.(457-459)CGA>CGT	p.R153R	TSLP_uc003kpa.2_RNA|TSLP_uc010jbt.1_Silent_p.R57R	NM_033035	NP_149024	Q969D9	TSLP_HUMAN	thymic stromal lymphopoietin isoform 1	153						extracellular space	cytokine activity				0		all_cancers(142;2.72e-05)|all_epithelial(76;4.39e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0417)|Ovarian(225;0.0443)|Colorectal(57;0.0464)|all_lung(232;0.0507)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.24e-08)|Epithelial(69;1.54e-07)|all cancers(49;1.73e-05)|COAD - Colon adenocarcinoma(37;0.109)														---	---	---	---
SNCAIP	9627	broad.mit.edu	37	5	121786900	121786900	+	Silent	SNP	T	C	C			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:121786900T>C	uc003ksw.1	+	10	2564	c.2358T>C	c.(2356-2358)ACT>ACC	p.T786T	SNCAIP_uc011cwl.1_Silent_p.T344T|SNCAIP_uc003ksx.1_Silent_p.T833T|SNCAIP_uc003ksy.1_Silent_p.T420T|SNCAIP_uc003ksz.1_Silent_p.T420T|SNCAIP_uc010jcu.2_Silent_p.T382T|SNCAIP_uc011cwm.1_Silent_p.T420T|SNCAIP_uc003kta.1_Silent_p.T418T|SNCAIP_uc010jcv.1_RNA|SNCAIP_uc010jcw.1_Silent_p.T480T|SNCAIP_uc010jcx.1_Silent_p.T726T|uc003ktb.1_Intron|SNCAIP_uc003ktc.1_Silent_p.T302T	NM_005460	NP_005451	Q9Y6H5	SNCAP_HUMAN	synuclein alpha interacting protein	786					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)														---	---	---	---
EIF4E1B	253314	broad.mit.edu	37	5	176070195	176070195	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:176070195T>G	uc010jkf.1	+	4	712	c.128T>G	c.(127-129)CTG>CGG	p.L43R		NM_001099408	NP_001092878	A6NMX2	I4E1B_HUMAN	eukaryotic translation initiation factor 4E	43					regulation of translation	cytoplasm|mRNA cap binding complex	translation initiation factor activity				0	all_cancers(89;0.00185)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.00498)|all_neural(177;0.0212)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)															---	---	---	---
EIF4E1B	253314	broad.mit.edu	37	5	176070196	176070196	+	Silent	SNP	G	C	C			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:176070196G>C	uc010jkf.1	+	4	713	c.129G>C	c.(127-129)CTG>CTC	p.L43L		NM_001099408	NP_001092878	A6NMX2	I4E1B_HUMAN	eukaryotic translation initiation factor 4E	43					regulation of translation	cytoplasm|mRNA cap binding complex	translation initiation factor activity				0	all_cancers(89;0.00185)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.00498)|all_neural(177;0.0212)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)															---	---	---	---
BMP6	654	broad.mit.edu	37	6	7845400	7845400	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:7845400G>A	uc003mxu.3	+	2	870	c.692G>A	c.(691-693)CGT>CAT	p.R231H		NM_001718	NP_001709	P22004	BMP6_HUMAN	bone morphogenetic protein 6 preproprotein	231					BMP signaling pathway|cartilage development|growth|immune response|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	BMP receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity			large_intestine(2)|ovary(1)	3	Ovarian(93;0.0721)																	---	---	---	---
HIST1H3F	8968	broad.mit.edu	37	6	26250489	26250489	+	Silent	SNP	G	C	C			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:26250489G>C	uc003nhg.1	-	1	347	c.345C>G	c.(343-345)GCC>GCG	p.A115A	HIST1H2BH_uc003nhh.2_5'Flank	NM_021018	NP_066298	P68431	H31_HUMAN	histone cluster 1, H3f	115					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0																OREG0017241	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
ZNF311	282890	broad.mit.edu	37	6	28963343	28963343	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:28963343G>T	uc003nlu.2	-	7	1949	c.1436C>A	c.(1435-1437)GCC>GAC	p.A479D	ZNF311_uc011dlk.1_Missense_Mutation_p.A387D|ZNF311_uc003nlv.2_Missense_Mutation_p.A387D	NM_001010877	NP_001010877	Q5JNZ3	ZN311_HUMAN	zinc finger protein 311	479	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding				0																		---	---	---	---
VARS2	57176	broad.mit.edu	37	6	30889025	30889025	+	Silent	SNP	G	C	C			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:30889025G>C	uc003nsc.1	+	16	2207	c.1575G>C	c.(1573-1575)CGG>CGC	p.R525R	VARS2_uc011dmx.1_Silent_p.R525R|VARS2_uc011dmy.1_Silent_p.R385R|VARS2_uc011dmz.1_Silent_p.R555R|VARS2_uc011dna.1_Silent_p.R523R|VARS2_uc011dnb.1_RNA|VARS2_uc011dnc.1_RNA|VARS2_uc011dnd.1_5'UTR|VARS2_uc010jsg.1_5'UTR|VARS2_uc010jsh.1_5'Flank	NM_020442	NP_065175	Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial	525					valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			ovary(3)|central_nervous_system(1)	4																		---	---	---	---
UHRF1BP1	54887	broad.mit.edu	37	6	34802057	34802057	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:34802057C>G	uc003oju.3	+	5	636	c.402C>G	c.(400-402)ATC>ATG	p.I134M	UHRF1BP1_uc010jvm.1_RNA|UHRF1BP1_uc010jvn.2_RNA	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	ICBP90 binding protein 1	134										ovary(3)	3																		---	---	---	---
MEP1A	4224	broad.mit.edu	37	6	46787351	46787351	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:46787351G>A	uc010jzh.1	+	7	508	c.466G>A	c.(466-468)GAG>AAG	p.E156K	MEP1A_uc011dwg.1_5'UTR|MEP1A_uc011dwh.1_Missense_Mutation_p.E184K|MEP1A_uc011dwi.1_Missense_Mutation_p.E56K	NM_005588	NP_005579	Q16819	MEP1A_HUMAN	meprin A alpha precursor	156	Extracellular (Potential).|Metalloprotease.	By similarity.			digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			pancreas(2)|ovary(1)	3			Lung(136;0.192)															---	---	---	---
GPR110	266977	broad.mit.edu	37	6	46996775	46996775	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:46996775A>G	uc003oyt.2	-	2	222	c.23T>C	c.(22-24)CTC>CCC	p.L8P	GPR110_uc011dwl.1_5'UTR|GPR110_uc003oyu.1_Missense_Mutation_p.L8P	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	8					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3																		---	---	---	---
KIAA1586	57691	broad.mit.edu	37	6	56918083	56918083	+	Silent	SNP	T	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:56918083T>G	uc003pdj.2	+	4	956	c.786T>G	c.(784-786)CCT>CCG	p.P262P	KIAA1586_uc011dxm.1_Silent_p.P235P	NM_020931	NP_065982	Q9HCI6	K1586_HUMAN	hypothetical protein LOC57691	262							nucleic acid binding				0	Lung NSC(77;0.0969)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)															---	---	---	---
PHF3	23469	broad.mit.edu	37	6	64410247	64410247	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:64410247T>A	uc003pep.1	+	8	3016	c.2990T>A	c.(2989-2991)TTT>TAT	p.F997Y	PHF3_uc010kah.1_Missense_Mutation_p.F811Y|PHF3_uc003pen.2_Missense_Mutation_p.F909Y|PHF3_uc011dxs.1_Missense_Mutation_p.F266Y	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	997	TFIIS central.				multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)															---	---	---	---
FRK	2444	broad.mit.edu	37	6	116289790	116289790	+	Silent	SNP	G	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:116289790G>A	uc003pwi.1	-	3	1026	c.579C>T	c.(577-579)TAC>TAT	p.Y193Y		NM_002031	NP_002022	P42685	FRK_HUMAN	fyn-related kinase	193	SH2.				negative regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding	p.Y193*(1)		ovary(3)|lung(3)	6		all_cancers(87;0.00559)|all_epithelial(87;0.00738)|Colorectal(196;0.0465)		all cancers(137;0.0128)|OV - Ovarian serous cystadenocarcinoma(136;0.0209)|GBM - Glioblastoma multiforme(226;0.0459)|Epithelial(106;0.0625)														---	---	---	---
GJA1	2697	broad.mit.edu	37	6	121768767	121768767	+	Silent	SNP	A	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:121768767A>G	uc003pyr.2	+	2	1024	c.774A>G	c.(772-774)AAA>AAG	p.K258K	GJA1_uc011ebo.1_Silent_p.K159K|GJA1_uc011ebp.1_Silent_p.K46K	NM_000165	NP_000156	P17302	CXA1_HUMAN	connexin 43	258	Cytoplasmic (Potential).				cell-cell signaling|cellular membrane organization|gap junction assembly|heart development|muscle contraction|positive regulation of I-kappaB kinase/NF-kappaB cascade	connexon complex|Golgi-associated vesicle membrane|integral to plasma membrane|membrane raft	ion transmembrane transporter activity|signal transducer activity			ovary(2)	2				GBM - Glioblastoma multiforme(226;0.00252)	Carvedilol(DB01136)													---	---	---	---
SDK1	221935	broad.mit.edu	37	7	3991461	3991461	+	Silent	SNP	G	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:3991461G>A	uc003smx.2	+	7	1198	c.1059G>A	c.(1057-1059)ACG>ACA	p.T353T		NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	353	Ig-like C2-type 3.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)														---	---	---	---
AVL9	23080	broad.mit.edu	37	7	32599065	32599065	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:32599065A>G	uc003tcv.1	+	10	1350	c.1204A>G	c.(1204-1206)ATC>GTC	p.I402V	AVL9_uc011kai.1_Missense_Mutation_p.I402V|AVL9_uc010kwj.1_Missense_Mutation_p.I243V	NM_015060	NP_055875	Q8NBF6	AVL9_HUMAN	AVL9 homolog (S. cerevisiase)	402						integral to membrane					0																		---	---	---	---
SAMD9	54809	broad.mit.edu	37	7	92733244	92733244	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:92733244C>G	uc003umf.2	-	3	2423	c.2167G>C	c.(2167-2169)GAT>CAT	p.D723H	SAMD9_uc003umg.2_Missense_Mutation_p.D723H	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	723						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)															---	---	---	---
TRRAP	8295	broad.mit.edu	37	7	98546232	98546232	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:98546232G>A	uc003upp.2	+	34	4900	c.4691G>A	c.(4690-4692)CGA>CAA	p.R1564Q	TRRAP_uc011kis.1_Missense_Mutation_p.R1546Q|TRRAP_uc003upr.2_Missense_Mutation_p.R1263Q	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	1564					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)															---	---	---	---
CYP3A43	64816	broad.mit.edu	37	7	99453307	99453307	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99453307G>A	uc003urx.1	+	8	867	c.764G>A	c.(763-765)AGG>AAG	p.R255K	CYP3A43_uc003ury.1_Missense_Mutation_p.R255K|CYP3A43_uc003urz.1_Missense_Mutation_p.R255K|CYP3A43_uc003usa.1_RNA|CYP3A43_uc010lgi.1_Missense_Mutation_p.R145K|CYP3A43_uc003usb.1_Intron	NM_057095	NP_476436	Q9HB55	CP343_HUMAN	cytochrome P450, family 3, subfamily A,	255			Missing (in allele CYP3A43*2).		xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)|skin(1)	2	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)				Cetirizine(DB00341)|Doxycycline(DB00254)													---	---	---	---
FBXO24	26261	broad.mit.edu	37	7	100187902	100187902	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100187902A>G	uc003uvm.1	+	3	537	c.244A>G	c.(244-246)ATC>GTC	p.I82V	FBXO24_uc010lha.1_RNA|FBXO24_uc003uvl.1_Missense_Mutation_p.I82V|FBXO24_uc003uvn.1_Intron|uc011kjy.1_RNA|FBXO24_uc011kjz.1_Missense_Mutation_p.I120V|FBXO24_uc011kka.1_Missense_Mutation_p.I70V	NM_033506	NP_277041	O75426	FBX24_HUMAN	F-box only protein 24 isoform 1	82	F-box.					ubiquitin ligase complex	ubiquitin-protein ligase activity			ovary(3)|skin(1)	4	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)																	---	---	---	---
MUC17	140453	broad.mit.edu	37	7	100677750	100677750	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100677750C>G	uc003uxp.1	+	3	3106	c.3053C>G	c.(3052-3054)ACT>AGT	p.T1018S	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1018	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|15.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)																	---	---	---	---
PSMC2	5701	broad.mit.edu	37	7	103004686	103004686	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:103004686G>C	uc003vbs.2	+	8	758	c.688G>C	c.(688-690)GCT>CCT	p.A230P	SLC26A5_uc003vbt.1_Intron|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|PSMC2_uc011klo.1_Missense_Mutation_p.A93P	NM_002803	NP_002794	P35998	PRS7_HUMAN	proteasome 26S ATPase subunit 2	230					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0																		---	---	---	---
RNF133	168433	broad.mit.edu	37	7	122338599	122338599	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:122338599C>T	uc003vkj.1	-	1	610	c.374G>A	c.(373-375)AGT>AAT	p.S125N	CADPS2_uc010lkp.2_Intron|CADPS2_uc010lkq.2_Intron	NM_139175	NP_631914	Q8WVZ7	RN133_HUMAN	ring finger protein 133	125	PA.					endoplasmic reticulum membrane|integral to membrane	ligase activity|zinc ion binding			skin(1)	1																		---	---	---	---
XPO7	23039	broad.mit.edu	37	8	21856712	21856712	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:21856712T>A	uc003xaa.3	+	23	2641	c.2539T>A	c.(2539-2541)TAC>AAC	p.Y847N	XPO7_uc010lti.2_Missense_Mutation_p.Y856N|XPO7_uc010ltk.2_Missense_Mutation_p.Y848N	NM_015024	NP_055839	Q9UIA9	XPO7_HUMAN	exportin 7 isoform b	847					mRNA transport|protein export from nucleus|transmembrane transport	cytoplasm|nuclear pore	nuclear export signal receptor activity|protein transporter activity			ovary(1)|kidney(1)|breast(1)|central_nervous_system(1)|pancreas(1)	5				Colorectal(74;0.0187)|COAD - Colon adenocarcinoma(73;0.0724)														---	---	---	---
XPO7	23039	broad.mit.edu	37	8	21856729	21856729	+	Silent	SNP	C	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:21856729C>G	uc003xaa.3	+	23	2658	c.2556C>G	c.(2554-2556)GTC>GTG	p.V852V	XPO7_uc010lti.2_Silent_p.V861V|XPO7_uc010ltk.2_Silent_p.V853V	NM_015024	NP_055839	Q9UIA9	XPO7_HUMAN	exportin 7 isoform b	852					mRNA transport|protein export from nucleus|transmembrane transport	cytoplasm|nuclear pore	nuclear export signal receptor activity|protein transporter activity			ovary(1)|kidney(1)|breast(1)|central_nervous_system(1)|pancreas(1)	5				Colorectal(74;0.0187)|COAD - Colon adenocarcinoma(73;0.0724)														---	---	---	---
CHRNA6	8973	broad.mit.edu	37	8	42611877	42611877	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:42611877C>G	uc003xpj.2	-	5	511	c.465G>C	c.(463-465)AAG>AAC	p.K155N	CHRNA6_uc011lcw.1_Missense_Mutation_p.K140N	NM_004198	NP_004189	Q15825	ACHA6_HUMAN	cholinergic receptor, nicotinic, alpha 6	155	Extracellular.					cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0	all_lung(13;3.33e-12)|Lung NSC(13;9.17e-11)|Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00439)|Lung NSC(58;0.0124)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	Lung(22;0.0252)|LUSC - Lung squamous cell carcinoma(45;0.0869)															---	---	---	---
POTEA	340441	broad.mit.edu	37	8	43173685	43173685	+	Silent	SNP	T	C	C			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:43173685T>C	uc003xpz.1	+	9	1150	c.1107T>C	c.(1105-1107)GAT>GAC	p.D369D	POTEA_uc003xqa.1_Silent_p.D323D	NM_001005365	NP_001005365	Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A isoform 2	369										ovary(1)	1																		---	---	---	---
CA8	767	broad.mit.edu	37	8	61192289	61192289	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:61192289T>C	uc003xtz.1	-	2	499	c.251A>G	c.(250-252)AAT>AGT	p.N84S	CA8_uc003xua.1_Missense_Mutation_p.N84S|CA8_uc003xub.2_Missense_Mutation_p.N84S	NM_004056	NP_004047	P35219	CAH8_HUMAN	carbonic anhydrase VIII	84					one-carbon metabolic process		carbonate dehydratase activity|zinc ion binding				0		all_cancers(86;0.172)|all_epithelial(80;0.0383)|all_lung(136;0.0413)|Lung NSC(129;0.0474)																---	---	---	---
CRISPLD1	83690	broad.mit.edu	37	8	75898238	75898238	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:75898238C>T	uc003yan.2	+	2	391	c.16C>T	c.(16-18)CGG>TGG	p.R6W		NM_031461	NP_113649	Q9H336	CRLD1_HUMAN	cysteine-rich secretory protein LCCL domain	6						extracellular region				ovary(1)|central_nervous_system(1)	2	Breast(64;0.0799)		Epithelial(68;0.155)|BRCA - Breast invasive adenocarcinoma(89;0.161)															---	---	---	---
ZFHX4	79776	broad.mit.edu	37	8	77690516	77690516	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:77690516A>G	uc003yav.2	+	4	3475	c.3088A>G	c.(3088-3090)ACC>GCC	p.T1030A	ZFHX4_uc003yau.1_Missense_Mutation_p.T1056A|ZFHX4_uc003yaw.1_Missense_Mutation_p.T1030A	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1030	C2H2-type 7.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)												HNSCC(33;0.089)			---	---	---	---
KLF10	7071	broad.mit.edu	37	8	103663556	103663556	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:103663556C>T	uc011lhk.1	-	3	1158	c.1004G>A	c.(1003-1005)AGC>AAC	p.S335N	KLF10_uc011lhj.1_Missense_Mutation_p.S324N	NM_005655	NP_005646	Q13118	KLF10_HUMAN	Kruppel-like factor 10 isoform a	335					cell proliferation|cell-cell signaling|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|skeletal system development|transforming growth factor beta receptor signaling pathway	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_epithelial(15;5.63e-07)|Lung NSC(17;8.18e-05)|all_lung(17;0.000169)		OV - Ovarian serous cystadenocarcinoma(57;0.000112)|STAD - Stomach adenocarcinoma(118;0.0826)															---	---	---	---
TMC1	117531	broad.mit.edu	37	9	75404223	75404223	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:75404223A>G	uc004aiz.1	+	15	1754	c.1214A>G	c.(1213-1215)GAA>GGA	p.E405G	TMC1_uc010moz.1_Missense_Mutation_p.E363G|TMC1_uc004aja.1_RNA|TMC1_uc004ajb.1_RNA|TMC1_uc004ajc.1_Missense_Mutation_p.E259G|TMC1_uc010mpa.1_Missense_Mutation_p.E259G	NM_138691	NP_619636	Q8TDI8	TMC1_HUMAN	transmembrane channel-like 1	405	Extracellular (Potential).				sensory perception of sound	integral to membrane				ovary(1)	1																		---	---	---	---
ROR2	4920	broad.mit.edu	37	9	94488878	94488878	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:94488878A>G	uc004arj.1	-	8	1530	c.1331T>C	c.(1330-1332)CTG>CCG	p.L444P	ROR2_uc004ari.1_Missense_Mutation_p.L304P|ROR2_uc004ark.2_Nonstop_Mutation_p.*433R	NM_004560	NP_004551	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	444	Cytoplasmic (Potential).				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			lung(8)|central_nervous_system(5)|ovary(3)|large_intestine(2)|stomach(1)|breast(1)	20																		---	---	---	---
C9orf84	158401	broad.mit.edu	37	9	114462308	114462308	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:114462308T>C	uc004bfr.2	-	22	3052	c.2917A>G	c.(2917-2919)ACA>GCA	p.T973A	C9orf84_uc011lwt.1_RNA|C9orf84_uc004bfq.2_Missense_Mutation_p.T934A|C9orf84_uc010mug.2_Missense_Mutation_p.T884A	NM_173521	NP_775792	Q5VXU9	CI084_HUMAN	hypothetical protein LOC158401 isoform 1	973										ovary(2)	2																		---	---	---	---
NUP214	8021	broad.mit.edu	37	9	134002902	134002902	+	Intron	SNP	T	C	C			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:134002902T>C	uc004cag.2	+						NUP214_uc004cah.2_Intron|NUP214_uc004caf.1_Intron	NM_005085	NP_005076			nucleoporin 214kDa						carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			breast(7)|lung(3)|skin(3)|ovary(2)|central_nervous_system(1)	16	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)				T	DEK|SET|ABL1	AML|T-ALL								---	---	---	---
CUBN	8029	broad.mit.edu	37	10	16967232	16967232	+	Intron	SNP	A	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:16967232A>G	uc001ioo.2	-							NM_001081	NP_001072			cubilin precursor						cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)													---	---	---	---
STAM	8027	broad.mit.edu	37	10	17730117	17730117	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:17730117C>T	uc001ipj.1	+	5	605	c.389C>T	c.(388-390)GCA>GTA	p.A130V	STAM_uc010qcf.1_Missense_Mutation_p.A19V	NM_003473	NP_003464	Q92783	STAM1_HUMAN	signal transducing adaptor molecule 1	130	VHS.				cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	SH3/SH2 adaptor activity			large_intestine(1)|ovary(1)	2																		---	---	---	---
CHAT	1103	broad.mit.edu	37	10	50857654	50857654	+	Silent	SNP	T	C	C			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:50857654T>C	uc001jhz.2	+	10	1636	c.1483T>C	c.(1483-1485)TTA>CTA	p.L495L	CHAT_uc001jhv.1_Silent_p.L377L|CHAT_uc001jhx.1_Silent_p.L377L|CHAT_uc001jhy.1_Silent_p.L377L|CHAT_uc001jia.2_Silent_p.L377L|CHAT_uc010qgs.1_Silent_p.L377L	NM_020549	NP_065574	P28329	CLAT_HUMAN	choline acetyltransferase isoform 2	495					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)	3		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)													---	---	---	---
UNC5B	219699	broad.mit.edu	37	10	73050856	73050856	+	Silent	SNP	G	C	C			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:73050856G>C	uc001jro.2	+	9	1729	c.1284G>C	c.(1282-1284)ACG>ACC	p.T428T	UNC5B_uc001jrp.2_Silent_p.T417T	NM_170744	NP_734465	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B precursor	428	Cytoplasmic (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane				ovary(2)|lung(1)	3																		---	---	---	---
BTAF1	9044	broad.mit.edu	37	10	93784681	93784681	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:93784681G>A	uc001khr.2	+	35	5130	c.5032G>A	c.(5032-5034)GAT>AAT	p.D1678N		NM_003972	NP_003963	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription	1678	Helicase C-terminal.				negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)																---	---	---	---
SORCS3	22986	broad.mit.edu	37	10	107005353	107005353	+	Silent	SNP	C	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:107005353C>T	uc001kyi.1	+	21	3149	c.2922C>T	c.(2920-2922)ACC>ACT	p.T974T	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	974	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)														---	---	---	---
EHF	26298	broad.mit.edu	37	11	34668128	34668128	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:34668128C>G	uc001mvr.1	+	3	351	c.240C>G	c.(238-240)ATC>ATG	p.I80M	EHF_uc009yke.1_Missense_Mutation_p.I80M|EHF_uc009ykf.1_Missense_Mutation_p.I83M	NM_012153	NP_036285	Q9NZC4	EHF_HUMAN	ets homologous factor	80	PNT.				cell proliferation|epithelial cell differentiation|multicellular organismal development|positive regulation of transcription, DNA-dependent		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_hematologic(20;0.117)	Epithelial(1;0.055)|all cancers(1;0.137)|STAD - Stomach adenocarcinoma(6;0.235)															---	---	---	---
ACCS	84680	broad.mit.edu	37	11	44105268	44105268	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:44105268C>A	uc009yks.1	+	15	1576	c.1432C>A	c.(1432-1434)CTT>ATT	p.L478I	EXT2_uc010rfo.1_Intron|ACCS_uc001mxx.2_Missense_Mutation_p.L478I	NM_001127219	NP_001120691	Q96QU6	1A1L1_HUMAN	1-aminocyclopropane-1-carboxylate synthase	478							1-aminocyclopropane-1-carboxylate synthase activity|protein homodimerization activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			breast(2)|ovary(1)|lung(1)	4																		---	---	---	---
OR4S2	219431	broad.mit.edu	37	11	55419242	55419242	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55419242G>T	uc001nhs.1	+	1	863	c.863G>T	c.(862-864)AGA>ATA	p.R288I		NM_001004059	NP_001004059	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S,	288	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.0748)																---	---	---	---
PRKRIR	5612	broad.mit.edu	37	11	76062596	76062596	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:76062596T>G	uc001oxh.1	-	5	1598	c.1598A>C	c.(1597-1599)GAA>GCA	p.E533A	PRKRIR_uc010rrz.1_Missense_Mutation_p.E358A	NM_004705	NP_004696	O43422	P52K_HUMAN	protein-kinase, interferon-inducible double	533					negative regulation of cell proliferation|response to stress|signal transduction		DNA binding|metal ion binding|protein dimerization activity			ovary(2)|pancreas(1)	3																		---	---	---	---
OPCML	4978	broad.mit.edu	37	11	132527132	132527132	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:132527132T>C	uc001qgs.2	-	2	300	c.250A>G	c.(250-252)ATA>GTA	p.I84V	OPCML_uc001qgu.2_Missense_Mutation_p.I77V|OPCML_uc010sck.1_Missense_Mutation_p.I84V|OPCML_uc001qgt.2_Missense_Mutation_p.I84V|OPCML_uc010scl.1_Missense_Mutation_p.I43V	NM_002545	NP_002536	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion	84	Ig-like C2-type 1.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			ovary(2)|skin(1)	3	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)														---	---	---	---
AKAP3	10566	broad.mit.edu	37	12	4737235	4737235	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:4737235G>A	uc001qnb.3	-	4	1062	c.833C>T	c.(832-834)ACG>ATG	p.T278M		NM_006422	NP_006413	O75969	AKAP3_HUMAN	A-kinase anchor protein 3	278					acrosome reaction|cellular component movement	acrosomal vesicle	protein kinase A binding			skin(3)|large_intestine(1)|ovary(1)|kidney(1)	6																		---	---	---	---
SLCO1C1	53919	broad.mit.edu	37	12	20903616	20903616	+	Silent	SNP	C	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:20903616C>A	uc001rej.3	+	15	2161	c.1806C>A	c.(1804-1806)ATC>ATA	p.I602I	SLCO1C1_uc010sii.1_Silent_p.I602I|SLCO1C1_uc010sij.1_Silent_p.I553I|SLCO1C1_uc009zip.2_Silent_p.I436I|SLCO1C1_uc001rei.2_Silent_p.I602I|SLCO1C1_uc010sik.1_Silent_p.I484I	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	602	Helical; Name=11; (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)																	---	---	---	---
IFLTD1	160492	broad.mit.edu	37	12	25656696	25656696	+	Nonstop_Mutation	SNP	A	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:25656696A>G	uc001rgs.2	-	8	1315	c.1165T>C	c.(1165-1167)TAA>CAA	p.*389Q	IFLTD1_uc001rgt.1_Nonstop_Mutation_p.*292Q|IFLTD1_uc010sji.1_Nonstop_Mutation_p.*410Q|IFLTD1_uc010sjj.1_Nonstop_Mutation_p.*326Q|IFLTD1_uc009zjc.2_Nonstop_Mutation_p.*370Q	NM_152590	NP_689803	Q8N9Z9	ILFT1_HUMAN	intermediate filament tail domain containing 1	389						intermediate filament	structural molecule activity			ovary(2)|central_nervous_system(1)	3	all_lung(3;2.75e-22)|Lung NSC(3;1.77e-21)|all_hematologic(7;0.00656)|Colorectal(261;0.0847)																	---	---	---	---
DENND5B	160518	broad.mit.edu	37	12	31586079	31586079	+	Intron	SNP	G	C	C			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:31586079G>C	uc001rki.1	-						DENND5B_uc001rkh.1_Intron|DENND5B_uc009zjq.1_Intron|DENND5B_uc001rkj.2_Missense_Mutation_p.L728V	NM_144973	NP_659410			DENN/MADD domain containing 5B							integral to membrane				ovary(1)|central_nervous_system(1)	2																		---	---	---	---
SCN8A	6334	broad.mit.edu	37	12	52156331	52156331	+	Silent	SNP	A	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:52156331A>T	uc001ryw.2	+	15	2593	c.2415A>T	c.(2413-2415)ATA>ATT	p.I805I	SCN8A_uc010snl.1_Silent_p.I670I|SCN8A_uc001ryy.2_Silent_p.I670I	NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	805	Helical; Name=S2 of repeat II; (Potential).|II.				axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)													---	---	---	---
ESPL1	9700	broad.mit.edu	37	12	53666524	53666524	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:53666524G>T	uc001sck.2	+	6	1480	c.1389G>T	c.(1387-1389)TTG>TTT	p.L463F	ESPL1_uc001scj.2_Missense_Mutation_p.L138F	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	463					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3																		---	---	---	---
DCD	117159	broad.mit.edu	37	12	55039490	55039490	+	Silent	SNP	A	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:55039490A>G	uc001sgj.2	-	3	161	c.99T>C	c.(97-99)CCT>CCC	p.P33P	DCD_uc009znt.2_Silent_p.P33P|DCD_uc009znu.2_RNA	NM_053283	NP_444513	P81605	DCD_HUMAN	dermcidin preproprotein	33					defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular region	protein binding			ovary(1)	1		Myeloproliferative disorder(1001;0.0255)																---	---	---	---
OR6C74	254783	broad.mit.edu	37	12	55641926	55641926	+	Silent	SNP	C	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:55641926C>A	uc010spg.1	+	1	855	c.855C>A	c.(853-855)CCC>CCA	p.P285P		NM_001005490	NP_001005490	A6NCV1	O6C74_HUMAN	olfactory receptor, family 6, subfamily C,	285	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1																		---	---	---	---
LRRIQ1	84125	broad.mit.edu	37	12	85438514	85438514	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:85438514T>A	uc001tac.2	+	4	374	c.263T>A	c.(262-264)GTT>GAT	p.V88D	LRRIQ1_uc001tab.1_Missense_Mutation_p.V88D|LRRIQ1_uc001taa.1_Missense_Mutation_p.V88D|LRRIQ1_uc001tad.2_5'UTR	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	88										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)														---	---	---	---
PLXNC1	10154	broad.mit.edu	37	12	94673350	94673350	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:94673350A>G	uc001tdc.2	+	22	3949	c.3700A>G	c.(3700-3702)AAA>GAA	p.K1234E	PLXNC1_uc010sut.1_Missense_Mutation_p.K281E|PLXNC1_uc009zsv.2_5'UTR	NM_005761	NP_005752	O60486	PLXC1_HUMAN	plexin C1 precursor	1234	Cytoplasmic (Potential).				axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
C12orf63	374467	broad.mit.edu	37	12	97087490	97087490	+	Intron	SNP	C	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:97087490C>G	uc001tet.1	+							NM_198520	NP_940922			hypothetical protein LOC374467											skin(6)|ovary(1)	7																		---	---	---	---
ANKS1B	56899	broad.mit.edu	37	12	99640323	99640323	+	Silent	SNP	G	C	C			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:99640323G>C	uc001tge.1	-	13	2493	c.2076C>G	c.(2074-2076)ACC>ACG	p.T692T	ANKS1B_uc001tgf.1_Silent_p.T272T|ANKS1B_uc001tgk.2_5'UTR|ANKS1B_uc009ztt.1_Silent_p.T658T	NM_152788	NP_690001	Q7Z6G8	ANS1B_HUMAN	cajalin 2 isoform a	692						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)														---	---	---	---
C12orf48	55010	broad.mit.edu	37	12	102569440	102569440	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:102569440C>G	uc001tjf.2	+	7	1113	c.1001C>G	c.(1000-1002)GCT>GGT	p.A334G	C12orf48_uc001tjg.2_Missense_Mutation_p.A253G|C12orf48_uc010swa.1_Missense_Mutation_p.A411G|C12orf48_uc001tjh.2_Missense_Mutation_p.A253G|C12orf48_uc010swb.1_Intron|C12orf48_uc009zuc.2_Intron|C12orf48_uc001tjj.2_Missense_Mutation_p.A49G|C12orf48_uc001tjk.2_Intron|C12orf48_uc009zud.2_Intron	NM_017915	NP_060385	Q9NWS1	PR1BP_HUMAN	hypothetical protein LOC55010	334					response to DNA damage stimulus	cytoplasm|nucleus	DNA binding				0																		---	---	---	---
DNAJC15	29103	broad.mit.edu	37	13	43643111	43643111	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:43643111C>G	uc001uyy.2	+	3	607	c.206C>G	c.(205-207)ACA>AGA	p.T69R		NM_013238	NP_037370	Q9Y5T4	DJC15_HUMAN	DNAJ domain-containing	69						integral to membrane	heat shock protein binding				0		Lung NSC(96;4.3e-06)|Breast(139;0.00869)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		GBM - Glioblastoma multiforme(144;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0737)														---	---	---	---
ATP11A	23250	broad.mit.edu	37	13	113510249	113510249	+	Silent	SNP	C	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:113510249C>T	uc001vsi.3	+	20	2356	c.2268C>T	c.(2266-2268)TAC>TAT	p.Y756Y	ATP11A_uc001vsj.3_Silent_p.Y756Y|ATP11A_uc001vsm.1_Silent_p.Y632Y|ATP11A_uc010ago.2_RNA	NM_015205	NP_056020	P98196	AT11A_HUMAN	ATPase, class VI, type 11A isoform a	756	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)																---	---	---	---
Unknown	0	broad.mit.edu	37	14	22509361	22509361	+	Intron	SNP	A	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:22509361A>G	uc001wbw.2	+						uc010tmh.1_Intron|uc010aiv.1_Intron|uc010tmi.1_Intron|uc010tmj.1_Intron|uc010aja.1_Intron|uc010tmk.1_Intron|uc010tmo.1_Intron|uc001wco.2_Intron|uc010aje.1_Intron|uc001wcp.2_Intron|uc001wcr.1_Intron|uc001wcs.1_Intron|uc010ajf.1_Intron|uc010ajg.1_Missense_Mutation_p.K100R					SubName: Full=Alpha-chain C region; Flags: Fragment;																														---	---	---	---
KLHL28	54813	broad.mit.edu	37	14	45414529	45414529	+	Silent	SNP	T	C	C			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:45414529T>C	uc001wvq.2	-	2	849	c.603A>G	c.(601-603)GCA>GCG	p.A201A	KLHL28_uc001wvr.2_Silent_p.A201A|KLHL28_uc001wvt.3_Silent_p.A201A	NM_017658	NP_060128	Q9NXS3	KLH28_HUMAN	BTB (POZ) domain containing 5	201										ovary(1)	1																		---	---	---	---
CGRRF1	10668	broad.mit.edu	37	14	55004881	55004881	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:55004881C>G	uc001xay.2	+	6	870	c.779C>G	c.(778-780)TCT>TGT	p.S260C	CGRRF1_uc001xaz.2_RNA	NM_006568	NP_006559	Q99675	CGRF1_HUMAN	cell growth regulator with ring finger domain 1	260					cell cycle arrest|negative regulation of cell proliferation|response to stress		zinc ion binding			ovary(1)	1																		---	---	---	---
WDHD1	11169	broad.mit.edu	37	14	55451447	55451447	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:55451447C>G	uc001xbm.1	-	15	1978	c.1900G>C	c.(1900-1902)GCT>CCT	p.A634P	WDHD1_uc010aom.1_Missense_Mutation_p.A151P|WDHD1_uc001xbn.1_Missense_Mutation_p.A511P	NM_007086	NP_009017	O75717	WDHD1_HUMAN	WD repeat and HMG-box DNA binding protein 1	634						cytoplasm|nucleoplasm	DNA binding			skin(1)	1																		---	---	---	---
FBXO34	55030	broad.mit.edu	37	14	55817527	55817527	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:55817527C>G	uc001xbu.2	+	2	664	c.419C>G	c.(418-420)TCC>TGC	p.S140C	FBXO34_uc001xbv.2_RNA|FBXO34_uc010aoo.2_Missense_Mutation_p.S140C	NM_017943	NP_060413	Q9NWN3	FBX34_HUMAN	F-box only protein 34	140										ovary(2)|lung(2)|skin(1)	5																		---	---	---	---
SFRS5	6430	broad.mit.edu	37	14	70235352	70235352	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:70235352C>G	uc001xll.2	+	4	1609	c.158C>G	c.(157-159)GCT>GGT	p.A53G	SFRS5_uc001xlm.2_RNA|SFRS5_uc001xln.1_Missense_Mutation_p.A53G|SFRS5_uc001xlo.2_Missense_Mutation_p.A53G|SFRS5_uc001xlp.2_Missense_Mutation_p.A53G|SFRS5_uc001xlq.2_Missense_Mutation_p.A50G	NM_006925	NP_008856	Q13243	SRSF5_HUMAN	splicing factor, arginine/serine-rich 5	53	RRM 1.				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|protein binding|RNA binding				0				all cancers(60;0.00144)|BRCA - Breast invasive adenocarcinoma(234;0.0132)|OV - Ovarian serous cystadenocarcinoma(108;0.0154)														---	---	---	---
ADAM20	8748	broad.mit.edu	37	14	70990979	70990979	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:70990979T>A	uc001xme.2	-	2	891	c.646A>T	c.(646-648)ACA>TCA	p.T216S		NM_003814	NP_003805	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20 preproprotein	166					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)														---	---	---	---
ESRRB	2103	broad.mit.edu	37	14	76928915	76928915	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:76928915C>G	uc001xsq.1	+	3	492	c.425C>G	c.(424-426)ACC>AGC	p.T142S	ESRRB_uc001xsr.2_Missense_Mutation_p.T142S|ESRRB_uc001xso.2_RNA	NM_004452	NP_004443	A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	142						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.0213)														---	---	---	---
ISM2	145501	broad.mit.edu	37	14	77948847	77948847	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:77948847T>C	uc001xtz.2	-	4	865	c.791A>G	c.(790-792)GAG>GGG	p.E264G	ISM2_uc001xua.2_Intron|ISM2_uc001xty.2_Missense_Mutation_p.E176G|ISM2_uc010tvl.1_Missense_Mutation_p.E183G	NM_199296	NP_954993	Q6H9L7	ISM2_HUMAN	isthmin 2 homolog isoform 1	264						extracellular region				skin(1)	1																		---	---	---	---
ADAM6	8755	broad.mit.edu	37	14	106452670	106452670	+	RNA	SNP	C	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:106452670C>T	uc010tyt.1	-	1975		c.38086G>A								Parts of antibodies, mostly variable regions.												0																		---	---	---	---
GABRA5	2558	broad.mit.edu	37	15	27193231	27193231	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:27193231G>A	uc001zbd.1	+	12	1579	c.1240G>A	c.(1240-1242)GAA>AAA	p.E414K	GABRA5_uc001zbe.1_RNA	NM_000810	NP_000801	P31644	GBRA5_HUMAN	gamma-aminobutyric acid A receptor, alpha 5	414	Cytoplasmic (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(1)	1		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)													---	---	---	---
OTUD7A	161725	broad.mit.edu	37	15	31795994	31795994	+	Silent	SNP	G	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:31795994G>A	uc001zfq.2	-	7	993	c.900C>T	c.(898-900)TAC>TAT	p.Y300Y	OTUD7A_uc001zfr.2_Silent_p.Y307Y	NM_130901	NP_570971	Q8TE49	OTU7A_HUMAN	OTU domain containing 7A	300	OTU.|Catalytic (By similarity).|TRAF-binding (By similarity).					cytoplasm|nucleus	cysteine-type peptidase activity|DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		all_lung(180;1.6e-09)		all cancers(64;2.44e-19)|Epithelial(43;6.82e-14)|GBM - Glioblastoma multiforme(186;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00189)|Lung(196;0.208)														---	---	---	---
C15orf55	256646	broad.mit.edu	37	15	34638243	34638243	+	Intron	SNP	C	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:34638243C>G	uc001zif.2	+						NOP10_uc001zie.1_5'Flank|C15orf55_uc010ucc.1_Intron|C15orf55_uc010ucd.1_Intron	NM_175741	NP_786883			nuclear protein in testis							cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)				T	BRD3|BRD4	lethal midline carcinoma								---	---	---	---
PLCB2	5330	broad.mit.edu	37	15	40595516	40595516	+	Silent	SNP	G	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:40595516G>A	uc001zld.2	-	3	505	c.204C>T	c.(202-204)CGC>CGT	p.R68R	PLCB2_uc010bbo.2_Silent_p.R68R|PLCB2_uc010ucm.1_Silent_p.R68R|PLCB2_uc001zle.3_Silent_p.R68R	NM_004573	NP_004564	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	68					activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(3)|breast(3)|kidney(1)|pancreas(1)	8		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)														---	---	---	---
GPR139	124274	broad.mit.edu	37	16	20043247	20043247	+	Missense_Mutation	SNP	C	T	T	rs144836581		TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:20043247C>T	uc002dgu.1	-	2	1034	c.872G>A	c.(871-873)CGG>CAG	p.R291Q	GPR139_uc010vaw.1_Missense_Mutation_p.R198Q	NM_001002911	NP_001002911	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	291	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(2)	2																		---	---	---	---
SCNN1B	6338	broad.mit.edu	37	16	23388519	23388519	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:23388519C>T	uc002dln.2	+	9	1480	c.1304C>T	c.(1303-1305)GCG>GTG	p.A435V		NM_000336	NP_000327	P51168	SCNNB_HUMAN	sodium channel, nonvoltage-gated 1, beta	435	Extracellular (By similarity).				excretion|sensory perception of taste	apical plasma membrane	ligand-gated sodium channel activity|WW domain binding			ovary(3)|breast(2)|large_intestine(1)|pancreas(1)	7				GBM - Glioblastoma multiforme(48;0.0465)	Amiloride(DB00594)|Triamterene(DB00384)													---	---	---	---
CORO1A	11151	broad.mit.edu	37	16	30199292	30199292	+	Silent	SNP	C	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:30199292C>T	uc002dww.2	+	8	1013	c.891C>T	c.(889-891)ATC>ATT	p.I297I	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|CORO1A_uc010bzq.2_Silent_p.I297I|CORO1A_uc010bzr.2_Silent_p.I297I|CORO1A_uc002dwx.2_Silent_p.I191I|CORO1A_uc002dwy.1_3'UTR|LOC606724_uc002dwz.1_5'Flank	NM_007074	NP_009005	P31146	COR1A_HUMAN	coronin, actin binding protein, 1A	297					cell-substrate adhesion|innate immune response|leukocyte chemotaxis|negative regulation of actin nucleation|phagolysosome assembly|positive chemotaxis|regulation of cell shape|uropod organization	actin filament|cortical actin cytoskeleton|lamellipodium|phagocytic cup|phagocytic vesicle membrane	actin filament binding|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein homodimerization activity				0																		---	---	---	---
SEPHS2	22928	broad.mit.edu	37	16	30456419	30456419	+	Silent	SNP	C	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:30456419C>G	uc010ves.1	-	2	806	c.630G>C	c.(628-630)GTG>GTC	p.V210V	SEPHS2_uc002dyh.1_Silent_p.V153V|SEPHS2_uc010vet.1_Silent_p.V92V	NM_012248	NP_036380	Q99611	SPS2_HUMAN	selenophosphate synthetase 2	210					selenocysteine biosynthetic process		ATP binding|selenide, water dikinase activity			breast(2)	2																		---	---	---	---
RPGRIP1L	23322	broad.mit.edu	37	16	53698873	53698873	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:53698873C>G	uc002ehp.2	-	10	1216	c.1152G>C	c.(1150-1152)CAG>CAC	p.Q384H	RPGRIP1L_uc002eho.3_Missense_Mutation_p.Q384H|RPGRIP1L_uc010vgy.1_Missense_Mutation_p.Q384H|RPGRIP1L_uc010cbx.2_Missense_Mutation_p.Q384H|RPGRIP1L_uc010vgz.1_Missense_Mutation_p.Q384H	NM_015272	NP_056087	Q68CZ1	FTM_HUMAN	RPGRIP1-like isoform a	384	Potential.				negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			ovary(1)	1		all_cancers(37;0.0973)																---	---	---	---
MIR328	442901	broad.mit.edu	37	16	67236265	67236265	+	RNA	SNP	T	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67236265T>G	hsa-mir-328|MI0000804	-			c.34T>G			ELMO3_uc002esa.2_Intron|ELMO3_uc002esb.2_Intron|ELMO3_uc002esc.2_Intron|uc010vjf.1_RNA																	0																		---	---	---	---
SGSM2	9905	broad.mit.edu	37	17	2268360	2268360	+	Intron	SNP	G	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:2268360G>A	uc002fun.3	+						SGSM2_uc002fum.3_Intron|SGSM2_uc010vqw.1_Intron|SGSM2_uc002fuo.2_5'Flank	NM_001098509	NP_001091979			RUN and TBC1 domain containing 1 isoform 2							intracellular	Rab GTPase activator activity				0				Colorectal(2;5.15e-05)|READ - Rectum adenocarcinoma(2;0.000115)														---	---	---	---
OR1A1	8383	broad.mit.edu	37	17	3119403	3119403	+	Silent	SNP	A	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:3119403A>G	uc010vrc.1	+	1	489	c.489A>G	c.(487-489)ACA>ACG	p.T163T		NM_014565	NP_055380	Q9P1Q5	OR1A1_HUMAN	olfactory receptor, family 1, subfamily A,	163	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2																		---	---	---	---
TMEM95	339168	broad.mit.edu	37	17	7259205	7259205	+	Missense_Mutation	SNP	G	A	A	rs79041177	byFrequency;by1000genomes	TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7259205G>A	uc002ggh.1	+	3	302	c.275G>A	c.(274-276)CGA>CAA	p.R92Q	TMEM95_uc002ggf.1_Missense_Mutation_p.R92Q|TMEM95_uc002ggg.1_Missense_Mutation_p.R92Q	NM_198154	NP_937797	Q3KNT9	TMM95_HUMAN	transmembrane protein 95	92	Extracellular (Potential).					integral to membrane					0		Prostate(122;0.173)														OREG0024137	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
TP53	7157	broad.mit.edu	37	17	7578403	7578403	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7578403C>A	uc002gim.2	-	5	721	c.527G>T	c.(526-528)TGC>TTC	p.C176F	TP53_uc002gig.1_Missense_Mutation_p.C176F|TP53_uc002gih.2_Missense_Mutation_p.C176F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C44F|TP53_uc010cng.1_Missense_Mutation_p.C44F|TP53_uc002gii.1_Missense_Mutation_p.C44F|TP53_uc010cnh.1_Missense_Mutation_p.C176F|TP53_uc010cni.1_Missense_Mutation_p.C176F|TP53_uc002gij.2_Missense_Mutation_p.C176F|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.C83F|TP53_uc002gio.2_Missense_Mutation_p.C44F|TP53_uc010vug.1_Missense_Mutation_p.C137F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	176	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).	Zinc.	CP -> FS (in a sporadic cancer; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in sporadic cancers; somatic mutation).|C -> F (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C176F(102)|p.C176Y(56)|p.C176S(19)|p.C176W(11)|p.C176R(8)|p.C176fs*71(7)|p.0?(7)|p.C176*(6)|p.C176_R181delCPHHER(3)|p.R174fs*24(3)|p.C176G(3)|p.C176fs*5(3)|p.R175_E180delRCPHHE(3)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.C176fs*65(1)|p.C176_P177delCP(1)|p.V173fs*69(1)|p.C176fs*68(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.C44Y(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R42fs*24(1)|p.C83Y(1)|p.C176fs*72(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R174fs*70(1)|p.C176del(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.C176fs*6(1)|p.R174fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)			111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---	---
CORO6	84940	broad.mit.edu	37	17	27944627	27944627	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:27944627G>A	uc002hel.2	-	5	646	c.644C>T	c.(643-645)GCG>GTG	p.A215V	CORO6_uc002hem.2_Intron|CORO6_uc002hen.2_5'UTR	NM_032854	NP_116243	Q6QEF8	CORO6_HUMAN	coronin 6	215					actin cytoskeleton organization	actin cytoskeleton	actin filament binding				0																		---	---	---	---
AMAC1	146861	broad.mit.edu	37	17	33520885	33520885	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:33520885A>G	uc002hjd.2	-	1	528	c.442T>C	c.(442-444)TGC>CGC	p.C148R		NM_152462	NP_689675	Q8N808	AMAC1_HUMAN	acyl-malonyl condensing enzyme 1	148	DUF6 1.					integral to membrane					0				BRCA - Breast invasive adenocarcinoma(366;0.0917)														---	---	---	---
GAS2L2	246176	broad.mit.edu	37	17	34073002	34073002	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:34073002A>T	uc002hjv.1	-	6	1542	c.1514T>A	c.(1513-1515)ATC>AAC	p.I505N		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	505					cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)														---	---	---	---
SC65	10609	broad.mit.edu	37	17	39967493	39967493	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:39967493A>C	uc002hxt.2	-	2	790	c.506T>G	c.(505-507)CTC>CGC	p.L169R	FKBP10_uc002hxv.2_5'Flank|SC65_uc002hxu.2_Missense_Mutation_p.L260R	NM_006455	NP_006446	Q92791	SC65_HUMAN	synaptonemal complex protein SC65	169					synaptonemal complex assembly	nucleolus|synaptonemal complex	binding				0		Breast(137;0.000162)		BRCA - Breast invasive adenocarcinoma(366;0.149)														---	---	---	---
RNF157	114804	broad.mit.edu	37	17	74157975	74157975	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:74157975A>G	uc002jqz.2	-	10	970	c.901T>C	c.(901-903)TGT>CGT	p.C301R	RNF157_uc002jra.2_Missense_Mutation_p.C301R	NM_052916	NP_443148	Q96PX1	RN157_HUMAN	ring finger protein 157	301	RING-type.						zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(166;0.187)															---	---	---	---
APCDD1	147495	broad.mit.edu	37	18	10471557	10471557	+	Silent	SNP	C	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:10471557C>A	uc002kom.3	+	3	627	c.273C>A	c.(271-273)ATC>ATA	p.I91I		NM_153000	NP_694545	Q8J025	APCD1_HUMAN	adenomatosis polyposis coli down-regulated 1	91	Extracellular (Potential).				hair follicle development|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to plasma membrane	Wnt-protein binding				0				READ - Rectum adenocarcinoma(15;0.08)														---	---	---	---
SERPINB11	89778	broad.mit.edu	37	18	61378588	61378588	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:61378588C>A	uc002ljk.3	+	3	250	c.188C>A	c.(187-189)ACT>AAT	p.T63N	SERPINB11_uc010xes.1_Translation_Start_Site|SERPINB11_uc010dqd.2_Translation_Start_Site|SERPINB11_uc002ljj.3_Translation_Start_Site|SERPINB11_uc010dqe.2_Translation_Start_Site|SERPINB11_uc010dqf.2_Intron	NM_080475	NP_536723	Q96P15	SPB11_HUMAN	serpin peptidase inhibitor, clade B, member 11	63					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			breast(1)	1		Esophageal squamous(42;0.129)																---	---	---	---
EBI3	10148	broad.mit.edu	37	19	4236942	4236942	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4236942A>T	uc002lzu.2	+	5	555	c.547A>T	c.(547-549)ATT>TTT	p.I183F		NM_005755	NP_005746	Q14213	IL27B_HUMAN	Epstein-Barr virus induced 3 precursor	183	Fibronectin type-III 2.				humoral immune response|positive regulation of alpha-beta T cell proliferation|positive regulation of interferon-gamma biosynthetic process|T-helper 1 type immune response	extracellular space|plasma membrane	cytokine activity|cytokine receptor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0336)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
MUC16	94025	broad.mit.edu	37	19	9015743	9015743	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9015743C>A	uc002mkp.2	-	29	38284	c.38080G>T	c.(38080-38082)GCT>TCT	p.A12694S	MUC16_uc010xki.1_5'Flank	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12696	Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57																		---	---	---	---
OR7D4	125958	broad.mit.edu	37	19	9325461	9325461	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9325461G>C	uc002mla.1	-	1	53	c.53C>G	c.(52-54)TCA>TGA	p.S18*		NM_001005191	NP_001005191	Q8NG98	OR7D4_HUMAN	olfactory receptor, family 7, subfamily D,	18	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4																		---	---	---	---
SLC1A6	6511	broad.mit.edu	37	19	15073090	15073090	+	Missense_Mutation	SNP	G	A	A	rs141656938	byFrequency	TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:15073090G>A	uc002naa.1	-	5	667	c.659C>T	c.(658-660)CCG>CTG	p.P220L	SLC1A6_uc010dzu.1_Missense_Mutation_p.P220L|SLC1A6_uc010xod.1_Missense_Mutation_p.P156L|SLC1A6_uc002nab.2_Missense_Mutation_p.P220L|SLC1A6_uc002nac.2_Missense_Mutation_p.P220L	NM_005071	NP_005062	P48664	EAA4_HUMAN	solute carrier family 1 (high affinity	220	Extracellular (Potential).				synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			pancreas(3)|ovary(2)|skin(1)	6					L-Glutamic Acid(DB00142)													---	---	---	---
CPAMD8	27151	broad.mit.edu	37	19	17122395	17122395	+	Intron	SNP	C	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17122395C>A	uc002nfb.2	-							NM_015692	NP_056507			C3 and PZP-like, alpha-2-macroglobulin domain							extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13																		---	---	---	---
GPATCH1	55094	broad.mit.edu	37	19	33579069	33579069	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:33579069C>T	uc002nug.1	+	2	417	c.103C>T	c.(103-105)CAG>TAG	p.Q35*		NM_018025	NP_060495	Q9BRR8	GPTC1_HUMAN	G patch domain containing 1	35						catalytic step 2 spliceosome	nucleic acid binding			skin(1)	1	Esophageal squamous(110;0.137)																	---	---	---	---
UBA2	10054	broad.mit.edu	37	19	34949798	34949798	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:34949798A>C	uc002nvk.2	+	13	1440	c.1370A>C	c.(1369-1371)CAT>CCT	p.H457P	UBA2_uc010xrx.1_Missense_Mutation_p.H330P|UBA2_uc002nvl.2_Missense_Mutation_p.H361P	NM_005499	NP_005490	Q9UBT2	SAE2_HUMAN	SUMO-1 activating enzyme subunit 2	457					protein sumoylation	nucleus	ATP binding|enzyme activator activity|ligase activity|metal ion binding|protein heterodimerization activity|SUMO activating enzyme activity			ovary(1)	1	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)															---	---	---	---
NFKBID	84807	broad.mit.edu	37	19	36386918	36386918	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36386918G>T	uc002oci.1	-	9	1144	c.570C>A	c.(568-570)CAC>CAA	p.H190Q	NFKBID_uc002och.1_5'UTR|NFKBID_uc002ocj.1_Missense_Mutation_p.H205Q	NM_139239	NP_640332	Q8NI38	IKBD_HUMAN	nuclear factor of kappa light polypeptide gene	190	ANK 4.				inflammatory response	nucleus					0																		---	---	---	---
ZNF345	25850	broad.mit.edu	37	19	37369066	37369066	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:37369066A>C	uc002oex.2	+	3	1712	c.1334A>C	c.(1333-1335)CAG>CCG	p.Q445P	ZNF345_uc002oey.3_Missense_Mutation_p.Q445P|ZNF345_uc002oez.2_Intron	NM_003419	NP_003410	Q14585	ZN345_HUMAN	zinc finger protein 345	445	C2H2-type 14.				negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)															---	---	---	---
ZNF284	342909	broad.mit.edu	37	19	44585178	44585178	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:44585178C>T	uc002oyg.1	+	3	242	c.26C>T	c.(25-27)ACC>ATC	p.T9I	ZNF284_uc010ejd.2_RNA	NM_001037813	NP_001032902	Q2VY69	ZN284_HUMAN	zinc finger protein 284	9	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0435)																---	---	---	---
CRX	1406	broad.mit.edu	37	19	48342695	48342695	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:48342695C>T	uc002phq.3	+	4	575	c.371C>T	c.(370-372)TCC>TTC	p.S124F		NM_000554	NP_000545	O43186	CRX_HUMAN	cone-rod homeobox protein	124					organ morphogenesis|response to stimulus|visual perception		leucine zipper domain binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)	2		all_cancers(25;2.76e-09)|all_epithelial(76;7.01e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000266)|all cancers(93;0.000788)|Epithelial(262;0.0226)|GBM - Glioblastoma multiforme(486;0.0521)														---	---	---	---
IZUMO1	284359	broad.mit.edu	37	19	49244646	49244646	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49244646G>T	uc002pkj.2	-	9	1392	c.844C>A	c.(844-846)CCT>ACT	p.P282T	RASIP1_uc002pki.2_5'Flank|IZUMO1_uc010eme.2_RNA|IZUMO1_uc010emf.2_RNA	NM_182575	NP_872381	Q8IYV9	IZUM1_HUMAN	izumo sperm-egg fusion 1 precursor	282	Extracellular (Potential).				fusion of sperm to egg plasma membrane	integral to membrane				ovary(1)	1		all_lung(116;0.000156)|Lung NSC(112;0.000251)|all_epithelial(76;0.000761)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000348)|Epithelial(262;0.019)|GBM - Glioblastoma multiforme(486;0.022)														---	---	---	---
TULP2	7288	broad.mit.edu	37	19	49391498	49391498	+	Silent	SNP	C	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49391498C>T	uc002pkz.2	-	8	808	c.657G>A	c.(655-657)AAG>AAA	p.K219K		NM_003323	NP_003314	O00295	TULP2_HUMAN	tubby like protein 2	219					visual perception	cytoplasm|extracellular region				ovary(1)|kidney(1)|skin(1)	3		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000259)|all cancers(93;0.000435)|Epithelial(262;0.0221)|GBM - Glioblastoma multiforme(486;0.0234)														---	---	---	---
CPT1C	126129	broad.mit.edu	37	19	50210790	50210790	+	Silent	SNP	C	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50210790C>T	uc002ppj.2	+	12	1564	c.1359C>T	c.(1357-1359)TCC>TCT	p.S453S	CPT1C_uc002ppl.3_Silent_p.S419S|CPT1C_uc002ppi.2_Silent_p.S370S|CPT1C_uc002ppk.2_Silent_p.S442S|CPT1C_uc010eng.2_Silent_p.S453S|CPT1C_uc010enh.2_Silent_p.S453S|CPT1C_uc010ybc.1_Silent_p.S324S|CPT1C_uc010eni.1_Silent_p.S110S	NM_152359	NP_689572	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C isoform 2	453	Cytoplasmic (Potential).				fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)														---	---	---	---
NLRP5	126206	broad.mit.edu	37	19	56538777	56538777	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:56538777G>C	uc002qmj.2	+	7	1178	c.1178G>C	c.(1177-1179)AGT>ACT	p.S393T	NLRP5_uc002qmi.2_Missense_Mutation_p.S374T	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	393	NACHT.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)														---	---	---	---
ZNF667	63934	broad.mit.edu	37	19	56953014	56953014	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:56953014T>G	uc002qnd.2	-	5	1512	c.1350A>C	c.(1348-1350)AAA>AAC	p.K450N	ZNF667_uc010etl.2_Missense_Mutation_p.K232N|ZNF667_uc002qne.2_Missense_Mutation_p.K450N|ZNF667_uc010etm.2_Missense_Mutation_p.K393N	NM_022103	NP_071386	Q5HYK9	ZN667_HUMAN	zinc finger protein 667	450	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)														---	---	---	---
SIGLEC1	6614	broad.mit.edu	37	20	3686499	3686499	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:3686499C>A	uc002wja.2	-	3	598	c.598G>T	c.(598-600)GAG>TAG	p.E200*	SIGLEC1_uc002wiz.3_Nonsense_Mutation_p.E200*|SIGLEC1_uc002wjc.2_Nonsense_Mutation_p.E111*	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	200	Ig-like C2-type 1.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10																		---	---	---	---
MAVS	57506	broad.mit.edu	37	20	3842020	3842020	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:3842020C>G	uc002wjw.3	+	4	503	c.334C>G	c.(334-336)CTT>GTT	p.L112V	MAVS_uc010zqn.1_Intron|MAVS_uc002wjx.3_5'UTR|MAVS_uc002wjy.3_Intron	NM_020746	NP_065797	Q7Z434	MAVS_HUMAN	virus-induced signaling adapter	112	Pro-rich.|Cytoplasmic (Probable).				activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity				0																		---	---	---	---
PRNP	5621	broad.mit.edu	37	20	4680317	4680317	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:4680317C>T	uc002wku.2	+	2	814	c.451C>T	c.(451-453)CGT>TGT	p.R151C	PRNP_uc002wkv.2_Missense_Mutation_p.R151C|PRNP_uc002wkw.2_Missense_Mutation_p.R151C|PRNP_uc002wkx.2_Missense_Mutation_p.R151C|PRNP_uc002wkt.1_Missense_Mutation_p.R121C|PRNP_uc002wky.2_Missense_Mutation_p.R151C|PRNP_uc010gbe.1_Missense_Mutation_p.R151C	NM_001080122	NP_001073591	P04156	PRIO_HUMAN	prion protein preproprotein	151	Interaction with GRB2, ERI3 and SYN1 (By similarity).				axon guidance|cell cycle arrest|cellular copper ion homeostasis|metabolic process|negative regulation of activated T cell proliferation|negative regulation of calcineurin-NFAT signaling pathway|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-2 production|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T cell receptor signaling pathway|protein homooligomerization|response to oxidative stress	anchored to membrane|endoplasmic reticulum|extrinsic to membrane|Golgi apparatus|membrane raft|nucleus|plasma membrane	copper ion binding|identical protein binding|microtubule binding			central_nervous_system(1)	1					Tetracycline(DB00759)													---	---	---	---
MYH7B	57644	broad.mit.edu	37	20	33578800	33578800	+	Intron	SNP	C	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:33578800C>G	uc002xbi.1	+							NM_020884	NP_065935			myosin, heavy polypeptide 7B, cardiac muscle,							membrane|myosin filament	actin binding|ATP binding|motor activity			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00691)															---	---	---	---
PHF20	51230	broad.mit.edu	37	20	34430649	34430649	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:34430649G>A	uc002xek.1	+	3	349	c.238G>A	c.(238-240)GAA>AAA	p.E80K	PHF20_uc002xei.1_Missense_Mutation_p.E80K|PHF20_uc010gfo.1_Missense_Mutation_p.E80K|PHF20_uc002xej.1_5'UTR|PHF20_uc002xel.1_5'UTR	NM_016436	NP_057520	Q9BVI0	PHF20_HUMAN	PHD finger protein 20	80					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			ovary(1)	1	Breast(12;0.00631)|all_lung(11;0.0145)																	---	---	---	---
MFNG	4242	broad.mit.edu	37	22	37872993	37872993	+	Silent	SNP	A	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:37872993A>T	uc003ass.1	-	5	758	c.588T>A	c.(586-588)ACT>ACA	p.T196T	MFNG_uc011ani.1_Silent_p.T74T|MFNG_uc011anj.1_Silent_p.T182T	NM_002405	NP_002396	O00587	MFNG_HUMAN	O-fucosylpeptide	196	Lumenal (Potential).				pattern specification process	extracellular space|integral to Golgi membrane	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity			lung(1)	1	Melanoma(58;0.0574)																	---	---	---	---
MGAT3	4248	broad.mit.edu	37	22	39884750	39884750	+	Silent	SNP	C	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:39884750C>T	uc003axv.3	+	2	1637	c.1398C>T	c.(1396-1398)GAC>GAT	p.D466D	MGAT3_uc010gxy.2_Silent_p.D466D	NM_002409	NP_002400	Q09327	MGAT3_HUMAN	mannosyl (beta-1,4-)-glycoprotein	466	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity				0	Melanoma(58;0.04)																	---	---	---	---
MID1	4281	broad.mit.edu	37	X	10535579	10535579	+	Silent	SNP	T	C	C			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:10535579T>C	uc004cte.3	-	2	200	c.9A>G	c.(7-9)ACA>ACG	p.T3T	MID1_uc004ctd.3_5'Flank|MID1_uc004ctg.3_Silent_p.T3T|MID1_uc004cth.3_Silent_p.T3T|MID1_uc004ctk.3_Silent_p.T3T|MID1_uc004cti.3_Silent_p.T3T|MID1_uc004ctj.3_Silent_p.T3T|MID1_uc011mie.1_RNA|MID1_uc004ctm.1_Silent_p.T3T|MID1_uc004ctn.1_Silent_p.T3T|MID1_uc004cto.1_Silent_p.T3T|MID1_uc010ndw.1_5'Flank|MID1_uc004cts.1_5'Flank|MID1_uc004ctt.2_Silent_p.T3T|MID1_uc004ctu.2_Silent_p.T3T|MID1_uc004ctv.2_Silent_p.T3T|MID1_uc004ctw.2_Silent_p.T3T|MID1_uc010ndy.1_Silent_p.T3T|uc010ndz.1_5'Flank|MID1_uc004cty.2_Silent_p.T3T|MID1_uc004ctz.1_5'Flank|MID1_uc004cua.1_RNA|MID1_uc004cub.1_Silent_p.T3T|MID1_uc010nea.1_5'Flank|MID1_uc004cuc.1_Silent_p.T3T|MID1_uc004cud.1_Silent_p.T3T|MID1_uc004cue.1_Silent_p.T3T|MID1_uc004cuf.1_Silent_p.T3T|MID1_uc004cug.1_Silent_p.T3T	NM_033290	NP_150632	O15344	TRI18_HUMAN	midline 1	3					microtubule cytoskeleton organization|pattern specification process|positive regulation of stress-activated MAPK cascade	cytoplasm|microtubule|microtubule associated complex|spindle	ligase activity|ubiquitin protein ligase binding|zinc ion binding			ovary(2)|pancreas(1)	3																		---	---	---	---
WNK3	65267	broad.mit.edu	37	X	54324757	54324757	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:54324757C>G	uc004dtd.1	-	7	1688	c.1249G>C	c.(1249-1251)GAA>CAA	p.E417Q	WNK3_uc004dtc.1_Missense_Mutation_p.E417Q	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	417					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11																		---	---	---	---
ZBTB33	10009	broad.mit.edu	37	X	119387473	119387473	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:119387473T>C	uc004esn.1	+	2	431	c.203T>C	c.(202-204)GTT>GCT	p.V68A	ZBTB33_uc010nqm.1_Missense_Mutation_p.V68A	NM_006777	NP_006768	Q86T24	KAISO_HUMAN	kaiso	68	BTB.|Self-association (By similarity).|Interaction with NCOR1.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|nucleolus|plasma membrane	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3																		---	---	---	---
MBNL3	55796	broad.mit.edu	37	X	131540373	131540373	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:131540373G>T	uc004ewv.3	-	2	304	c.225C>A	c.(223-225)CAC>CAA	p.H75Q	uc004ewr.1_Intron|MBNL3_uc004eww.2_5'UTR|MBNL3_uc010nrl.1_RNA|MBNL3_uc004ews.2_5'UTR|MBNL3_uc004ewt.2_Missense_Mutation_p.H25Q|MBNL3_uc011muz.1_5'UTR|MBNL3_uc004ewu.3_Missense_Mutation_p.H75Q|MBNL3_uc004ewx.1_Missense_Mutation_p.H25Q	NM_018388	NP_060858	Q9NUK0	MBNL3_HUMAN	muscleblind-like 3 isoform G	75					mRNA processing|multicellular organismal development|regulation of RNA splicing|RNA splicing	Golgi apparatus|nucleus	nucleic acid binding|zinc ion binding				0	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
MAGEA4	4103	broad.mit.edu	37	X	151092840	151092840	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5717-01A-11D-1600-08	TCGA-CG-5717-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:151092840G>A	uc004fez.2	+	3	860	c.704G>A	c.(703-705)AGG>AAG	p.R235K	MAGEA4_uc004ffa.2_Missense_Mutation_p.R235K|MAGEA4_uc004ffb.2_Missense_Mutation_p.R235K|MAGEA4_uc004ffc.2_Missense_Mutation_p.R235K|MAGEA4_uc004ffd.2_Missense_Mutation_p.R235K	NM_002362	NP_002353	P43358	MAGA4_HUMAN	melanoma antigen family A, 4	235	MAGE.						protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
